FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Jo, E Zourdos, MC Wilson, JM Nosaka, KK Lee, SR Naimo, M Henning, PC Park, YM Khamoui, AV Park, BS Panton, LB Kim, JS AF Jo, Edward Zourdos, Michael C. Wilson, Jacob M. Nosaka, Ken Kazunori Lee, Sang-Rok Naimo, Marshall Henning, Paul C. Park, Young-Min Khamoui, Andy V. Park, Bong-Sup Panton, Lynn B. Kim, Jeong-Su TI Varying Muscle-Specific Exercise Between Consecutive Training Sessions does not Diminish the Repeated Bout Effect SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Jo, Edward; Zourdos, Michael C.; Lee, Sang-Rok; Naimo, Marshall; Khamoui, Andy V.; Park, Bong-Sup; Panton, Lynn B.; Kim, Jeong-Su] Florida State Univ, Tallahassee, FL 32306 USA. [Wilson, Jacob M.] Univ Tampa, Tampa, FL 33606 USA. [Nosaka, Ken Kazunori] Edith Cowan Univ, Joondalup, Australia. [Henning, Paul C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA USA. [Park, Young-Min] Syracuse Univ, Syracuse, NY USA. RI Nosaka, Kazunori/H-4412-2011 OI Nosaka, Kazunori/0000-0001-7373-4994 NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 458 EP 458 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363302654 ER PT J AU Purdy, AW Brechue, WF AF Purdy, Alexander W. Brechue, William F. TI Upper-body Work Capacity Assessed by Bench Press and Push-up Exercises. SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Purdy, Alexander W.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 516 EP 516 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303065 ER PT J AU Grunbeck, MR Beidleman, BA Muza, SR Andrew, SP Staab, JE Fulco, CS AF Grunbeck, Marie R. Beidleman, Beth A. Muza, Stephen R. Andrew, Sean P. Staab, Janet E. Fulco, Charles S. TI N-acetyl-cysteine Does Not Improve Cerebral Blood Flow Or Cerebral Oxygenation At An Altitude Of 3500m. SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Grunbeck, Marie R.; Beidleman, Beth A.; Muza, Stephen R.; Andrew, Sean P.; Staab, Janet E.; Fulco, Charles S.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 539 EP 539 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303141 ER PT J AU Staab, JE Beidleman, BA Fulco, CS Cymerman, A Rock, PB Muza, SR AF Staab, Janet E. Beidleman, Beth A. Fulco, Charles S. Cymerman, Allen Rock, Paul B. Muza, Stephen R. TI Male Gendered and Lower Arterial Oxygen Saturation are Associated with Acute Mountain Sickness SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Staab, Janet E.; Beidleman, Beth A.; Fulco, Charles S.; Cymerman, Allen; Muza, Stephen R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Rock, Paul B.] Oklahoma State Univ, Tulsa, OK USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 539 EP 539 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303143 ER PT J AU Simpson, K Hendrickson, NR Redmond, JE Cohen, BS Spiering, BA Knapik, JJ Sharp, MA AF Simpson, Kathleen Hendrickson, Nathan R. Redmond, Jan E. Cohen, Bruce S. Spiering, Barry A. Knapik, Joseph J. Sharp, Marilyn A. TI Comparison of Physical Activity Performed at Two US Army Basic Combat Training Sites SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Simpson, Kathleen; Hendrickson, Nathan R.; Redmond, Jan E.; Cohen, Bruce S.; Spiering, Barry A.; Sharp, Marilyn A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Knapik, Joseph J.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 559 EP 560 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303211 ER PT J AU Scofield, DE DeGroot, DW Ely, MR Karl, JP Young, AJ Nindl, BC AF Scofield, Dennis E. DeGroot, David W. Ely, Matthew R. Karl, J. Philip Young, Andrew J. Nindl, Bradley C. TI Post-exercise Growth Hormone Kinetics Differ Between Assay Methods During Energy Balance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Scofield, Dennis E.; DeGroot, David W.; Ely, Matthew R.; Karl, J. Philip; Young, Andrew J.; Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RI SCOFIELD, DENNIS/F-3636-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 607 EP 607 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303380 ER PT J AU Aguirre, NW Tan, JG Coats, DR Spiering, BA Brown, LE Coburn, JW Rubin, DA Judelson, DA AF Aguirre, Nicholas W. Tan, Jeremy G. Coats, Daniel R. Spiering, Barry A. Brown, Lee E. Coburn, Jared W. Rubin, Daniela A. Judelson, Daniel A. TI Effect Of Exercise Order On Cardiorespiratory And Perceptual Respones To Concurrent Exercise SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Aguirre, Nicholas W.; Tan, Jeremy G.; Coats, Daniel R.; Brown, Lee E.; Coburn, Jared W.; Rubin, Daniela A.; Judelson, Daniel A.] Calif State Univ Fullerton, Fullerton, CA 92634 USA. [Spiering, Barry A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RI Brown, Lee/A-1073-2013 OI Brown, Lee/0000-0001-6269-4616 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 614 EP 614 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303403 ER PT J AU Steelman, R Knapik, JJ Sharp, M Hendrickson, N Redmond, J Cohen, B Jones, BH AF Steelman, Ryan Knapik, Joseph J. Sharp, Marilyn Hendrickson, Nathan Redmond, Jan Cohen, Bruce Jones, Bruce H. TI Accuracy of Self-Reported Height and Weight among Basic Combat Trainees SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Steelman, Ryan; Knapik, Joseph J.; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Sharp, Marilyn; Hendrickson, Nathan; Redmond, Jan; Cohen, Bruce] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 641 EP 642 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303497 ER PT J AU Pujol, TJ Mayhew, JL Brechue, WF Reneau, P AF Pujol, Thomas J. Mayhew, Jerry L. Brechue, William F. Reneau, Paul TI Effect Of Free-weight And Machine-weight Training On Upper-body Strength Gains In Low- And High-strength College Women SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Pujol, Thomas J.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA. [Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Reneau, Paul] Fairmont State Univ, Fairmont, WV USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 671 EP 671 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363303600 ER PT J AU Huang, CJ McAlpine, DA Webb, HE Franco, RL Tangsilsat, SE Beasley, KN Kamimori, GH Acevedo, EO AF Huang, Chun-Jung McAlpine, David A. Webb, Heather E. Franco, Robert L. Tangsilsat, Supatchara E. Beasley, Kathleen N. Kamimori, Gary H. Acevedo, Edmund O. TI Impact Of Cardiovascular Fitness On Pentraxin 3 Levels In Response To Concurrent Stressors SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Huang, Chun-Jung; McAlpine, David A.; Beasley, Kathleen N.] Florida Atlantic Univ, Boca Raton, FL 33431 USA. [Webb, Heather E.] Mississippi State Univ, Starkville, MS USA. [Franco, Robert L.; Acevedo, Edmund O.] Virginia Commonwealth Univ, Richmond, VA USA. [Tangsilsat, Supatchara E.] Univ New S Wales, Sydney, NSW, Australia. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Webb, Heather/A-4219-2010 OI Webb, Heather/0000-0002-3925-9613 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 731 EP 732 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304017 ER PT J AU Reneau, P Skoff, B Mayhew, J Ryan, MJ Pujol, TJ Brechue, WF AF Reneau, Paul Skoff, Brandon Mayhew, Jerry Ryan, Michael J. Pujol, Thomas J. Brechue, William F. TI Accuracy of 1-RM Bench Press Prediction Equations in College-Age Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Reneau, Paul; Skoff, Brandon; Ryan, Michael J.] Fairmont State Univ, Fairmont, WV USA. [Mayhew, Jerry] Truman State Univ, Kirksville, MO USA. [Pujol, Thomas J.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 754 EP 754 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304090 ER PT J AU Skoff, B Reneau, P Ryan, MJ Mayhew, J Brechue, WF Pujol, TJ AF Skoff, Brandon Reneau, Paul Ryan, Michael J. Mayhew, Jerry Brechue, William F. Pujol, Thomas J. TI Effects of Training Status on Bench Press Prediction Accuracy from Repetitions and Lifting Load SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Skoff, Brandon; Reneau, Paul; Ryan, Michael J.] Fairmont State Univ, Fairmont, WV USA. [Mayhew, Jerry] Truman State Univ, Kirksville, MO USA. [Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. [Pujol, Thomas J.] SE Missouri State Univ, Cape Girardeau, MO 63701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 754 EP 754 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304089 ER PT J AU Green, MS Martin, TD Benson, AK Corona, BT Ingalls, CP AF Green, Michael S. Martin, Tyler D. Benson, Amanda K. Corona, Benjamin T. Ingalls, Christopher P. TI Ibuprofen Prolongs Functional Deficits after a Repeated Bout of Downhill Treadmill Running SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Green, Michael S.; Martin, Tyler D.; Benson, Amanda K.] Troy Univ, Troy, AL USA. [Corona, Benjamin T.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ingalls, Christopher P.] Georgia State Univ, Atlanta, GA 30303 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 767 EP 767 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304134 ER PT J AU Seay, JF Sauer, SG Frykman, PN Roy, T AF Seay, Joseph F. Sauer, Shane G. Frykman, Peter N. Roy, Tanja TI History of Low Back Pain affects Pelvis and Trunk Rotation During a Lift-Lower Task SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Seay, Joseph F.; Sauer, Shane G.; Frykman, Peter N.; Roy, Tanja] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 775 EP 775 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304162 ER PT J AU Kenefick, RW Sollanek, KJ Ely, BR Cheuvront, SN Sawka, MN AF Kenefick, Robert W. Sollanek, Kurt J. Ely, Brett R. Cheuvront, Samuel N. Sawka, Michael N. TI Effect of Hypohydration and Environment on Dynamic Postural Stability SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kenefick, Robert W.; Sollanek, Kurt J.; Ely, Brett R.; Cheuvront, Samuel N.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 788 EP 788 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304205 ER PT J AU Austin, KG Farina, EK Carvey, C Lieberman, HR AF Austin, Krista G. Farina, Emily K. Carvey, Christina Lieberman, Harris R. TI The Use of Nutritional Supplements for Weight Modification by US Army Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Austin, Krista G.; Farina, Emily K.; Carvey, Christina; Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 794 EP 794 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304227 ER PT J AU Wennblom, ME Brechue, WF AF Wennblom, Martin E. Brechue, William F. TI Fat Mass: Accumulation And Distribution In Athletes And Military Personnel SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Wennblom, Martin E.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 801 EP 801 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304249 ER PT J AU Clennin, M Taylor, BJ Hauret, KG Jones, BH AF Clennin, Morgan Taylor, Bonnie J. Hauret, Keith G. Jones, Bruce H. TI Air Evacuated Non-Battle Injuries Diagnosed As Sport-Related Musculoskeletal Conditions, Us Army 2001-2010 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Clennin, Morgan; Taylor, Bonnie J.; Hauret, Keith G.; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 836 EP 836 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304366 ER PT J AU Grier, T Canham-Chervak, M McNulty, V Jones, BH AF Grier, Tyson Canham-Chervak, Michelle McNulty, Vancil Jones, Bruce H. TI Risk Factors Associated with Running Injuries in the United States Army SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Grier, Tyson; Canham-Chervak, Michelle; McNulty, Vancil; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 3 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 836 EP 836 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304365 ER PT J AU Garrett, P Clearfield, E Westrick, A Hauret, KG Knapik, JJ Jones, BH AF Garrett, Phillip Clearfield, Elizabeth Westrick, Ashly Hauret, Keith G. Knapik, Joseph J. Jones, Bruce H. TI Seasonal Differences in Injury Risks in Basic Combat Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Garrett, Phillip; Clearfield, Elizabeth; Westrick, Ashly; Hauret, Keith G.; Knapik, Joseph J.; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 837 EP 837 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304368 ER PT J AU Hauret, KG Bedno, SA Kao, TC Jones, BH Loringer, K AF Hauret, Keith G. Bedno, Sheryl A. Kao, Tze-Cheg Jones, Bruce H. Loringer, Kelly TI Impact of Injuries from Sports, Exercise, and Recreational Activity among Active Duty Military Personnel SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Hauret, Keith G.; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Bedno, Sheryl A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Kao, Tze-Cheg] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Loringer, Kelly] 20th Med Grp, Ellsworth AFB, SD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 837 EP 838 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304370 ER PT J AU Lisman, PJ O'Connor, FG Deuster, PA Pappas, CG Knapik, JJ AF Lisman, Peter J. O'Connor, Francis G. Deuster, Patricia A. Pappas, Chris G. Knapik, Joseph J. TI Physical Fitness Tests' Ability To Predict Injuries In Officer Candidates And Their Association To FMS SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Lisman, Peter J.; O'Connor, Francis G.; Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Pappas, Chris G.] Womack Army Community Hosp, Ft Bragg, NC USA. [Knapik, Joseph J.] Publ Hlth Command Prov, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 837 EP 837 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304369 ER PT J AU Dawadi, S Hauret, KG Taylor, BJ Clennin, MN Jones, BH AF Dawadi, Shuva Hauret, Keith G. Taylor, Bonnie J. Clennin, Morgan N. Jones, Bruce H. TI Sports Injuries Among US Army Soldiers Deployed To Operations Iraqi And Enduring Freedom, 2001-2010 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Dawadi, Shuva; Hauret, Keith G.; Taylor, Bonnie J.; Clennin, Morgan N.; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 838 EP 839 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304374 ER PT J AU Knapik, JJ Montain, SJ McGraw, SM Grier, T Ely, MR Jones, BH AF Knapik, Joseph J. Montain, Scott J. McGraw, Susan M. Grier, Tyson Ely, Matthew R. Jones, Bruce H. TI Risk Factors for Stress Fractures in United States Army Basic Combat Training: A Retrospective Analysis of 632,440 Recruits SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Knapik, Joseph J.; Grier, Tyson; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Montain, Scott J.; McGraw, Susan M.; Ely, Matthew R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 838 EP 838 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304373 ER PT J AU Anderson, MK Grier, T Canham-Chervak, M Bushman, TT Waajid, M Jones, BH AF Anderson, Morgan K. Grier, Tyson Canham-Chervak, Michelle Bushman, Timothy T. Waajid, Malikah Jones, Bruce H. TI Risk Factors Associated With Lower Leg Injuries in the United States Army SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Anderson, Morgan K.; Grier, Tyson; Canham-Chervak, Michelle; Bushman, Timothy T.; Waajid, Malikah; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 840 EP 840 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304380 ER PT J AU Graham, BS Knapik, JJ Hoedebecke, K Rankin, S Klug, K Proctor, S Steelman, R Grier, T Jones, B AF Graham, Bria S. Knapik, Joesph J. Hoedebecke, Kyle Rankin, Shawn Klug, Kevin Proctor, Stanley Steelman, Ryan Grier, Tyson Jones, Bruce TI Risk Factors for Closed Head Injuries in Military Parachuting SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Graham, Bria S.; Knapik, Joesph J.; Steelman, Ryan; Grier, Tyson; Jones, Bruce] USA, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Hoedebecke, Kyle] Womack Army Med Ctr, Ft Bragg, NC USA. [Rankin, Shawn; Klug, Kevin; Proctor, Stanley] Concurrent Technol Corp, Fayetteville, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 840 EP 840 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304378 ER PT J AU Bushman, TT Grier, T Canham-Chervak, M Anderson, MK Waajid, M Jones, BH AF Bushman, Timothy T. Grier, Tyson Canham-Chervak, Michelle Anderson, Morgan K. Waajid, Malikah Jones, Bruce H. TI Injury Risk Associated with Functional Movement Screening in the United States Army SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Bushman, Timothy T.; Grier, Tyson; Canham-Chervak, Michelle; Anderson, Morgan K.; Waajid, Malikah; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 1 Z9 1 U1 1 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 842 EP 842 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304385 ER PT J AU Attipoe, S Lisman, P O'Connor, FG Deuster, PA Pappas, CG Knapik, JJ AF Attipoe, Selasi Lisman, Peter O'Connor, Francis G. Deuster, Patricia A. Pappas, Chris G. Knapik, Joseph J. TI Ability Of Previous Exercise Frequency To Predict Injuries In Officer Candidates And Its Association To FMS SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Attipoe, Selasi; Lisman, Peter; O'Connor, Francis G.; Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Pappas, Chris G.] Womack Army Community Hosp, Ft Bragg, NC USA. [Knapik, Joseph J.] Publ Hlth Command, Aberdeen Proving Ground, MD USA. RI Attipoe, Selasi/G-1938-2015 OI Attipoe, Selasi/0000-0001-9212-8412 NR 0 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 844 EP 844 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304395 ER PT J AU Greene, S Knapik, JJ Harris, A Graham, B Steelman, R Hauret, K Jones, BH AF Greene, Shamola Knapik, Joseph J. Harris, Andrea Graham, Bria Steelman, Ryan Hauret, Keith Jones, Bruce H. TI Association between Age and Fitness among Men and Women Entering Basic Combat Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Greene, Shamola; Knapik, Joseph J.; Harris, Andrea; Graham, Bria; Steelman, Ryan; Hauret, Keith; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 919 EP 919 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304649 ER PT J AU Harris, A Knapik, J Greene, S Hauret, K Graham, B Steelman, R Jones, B AF Harris, Andrea Knapik, Joseph Greene, Shamola Hauret, Keith Graham, Bria Steelman, Ryan Jones, Bruce TI Association between Physical Fitness and Discharge and Recycling Risk among Male Army Recruits SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Harris, Andrea; Knapik, Joseph; Greene, Shamola; Hauret, Keith; Graham, Bria; Steelman, Ryan; Jones, Bruce] US Army, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 919 EP 919 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304651 ER PT J AU Warr, BJ Alvar, BA Sharp, MA AF Warr, Bradley J. Alvar, Brent A. Sharp, Marilyn A. TI Self Reported Exercise during Deployment Correlates with Measured Fitness Outcomes SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Warr, Bradley J.; Sharp, Marilyn A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Alvar, Brent A.] Rocky Mt Univ Hlth Profess, Provo, UT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 925 EP 926 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304670 ER PT J AU Kobermann, AM Mayhew, JL Leahy, GD Crowder, T AF Kobermann, Andrea M. Mayhew, Jerry L. Leahy, Guy D. Crowder, Todd TI Relationship of Body Mass to Army Physical Fitness Test Performance in College ROTC Cadets SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Kobermann, Andrea M.; Mayhew, Jerry L.] Truman State Univ, Kirksville, MO USA. [Leahy, Guy D.] Davis Monthan AFB, Tucson, AZ USA. [Crowder, Todd] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 927 EP 927 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304675 ER PT J AU Gregory, RW Zifchock, RA Brechue, WF AF Gregory, Robert W. Zifchock, Rebecca A. Brechue, William F. TI Mechanics of a Biomechanical Energy Harvesting Ankle Device During Walking SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Gregory, Robert W.; Zifchock, Rebecca A.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 942 EP 943 PG 2 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304726 ER PT J AU Montain, SJ McGraw, SM Ely, MR Grier, T Knapik, JJ AF Montain, Scott J. McGraw, Susan M. Ely, Matthew R. Grier, Tyson Knapik, Joseph J. TI Low UV Index Does Not Increase The Risk Of Stress Or Lower Limb Fractures SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract C1 [Montain, Scott J.; McGraw, Susan M.; Ely, Matthew R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Grier, Tyson; Knapik, Joseph J.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2012 VL 44 SU 2 BP 952 EP 952 PG 1 WC Sport Sciences SC Sport Sciences GA 027OT UT WOS:000310363304757 ER PT J AU Gerdes, JW Gupta, SK Wilkerson, SA AF Gerdes, John W. Gupta, Satyandra K. Wilkerson, Stephen A. TI A Review of Bird-Inspired Flapping Wing Miniature Air Vehicle Designs SO JOURNAL OF MECHANISMS AND ROBOTICS-TRANSACTIONS OF THE ASME LA English DT Article ID INSECT FLIGHT; MECHANISMS; ROTATION; SENSORS; FORCES; MODEL; FLOW AB Physical and aerodynamic characteristics of a bird in flight offer benefits over typical propeller or rotor driven miniature air vehicle (MAV) locomotion designs in certain applications. A number of research groups and companies have developed flapping wing vehicles that attempt to harness these benefits. The purpose of this paper is to report different types of flapping wing miniature air vehicle designs and compare their salient characteristics. This paper is focused on mechanical design aspects of mechanisms and wings. The discussion presented will be limited to miniature-sized flapping wing air vehicles, defined as 10 to 100 g total weight. The discussion will be focused primarily on designs which have performed at least one successful test flight. This paper provides representative designs in each category, rather than providing a comprehensive listing of all existing designs. This paper will familiarize a newcomer to the field with existing designs and their distinguishing features. By studying existing designs, future designers will be able to adopt features from other successful designs. This paper also summarizes the design challenges associated with the further advancement of the field and deploying flapping wing vehicles in practice. [DOI: 10.1115/1.4005525] C1 [Gerdes, John W.; Gupta, Satyandra K.] Univ Maryland, Dept Mech Engn, College Pk, MD 20740 USA. [Gerdes, John W.; Gupta, Satyandra K.] Univ Maryland, Syst Res Inst, College Pk, MD 20740 USA. [Wilkerson, Stephen A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gerdes, JW (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20740 USA. FU U.S. Army Research Laboratory Vehicle Technologies Directorate; Science, Mathematics, and Research for Transformation Scholarship FX This work was sponsored by U.S. Army Research Laboratory Vehicle Technologies Directorate and the Science, Mathematics, and Research for Transformation Scholarship. NR 50 TC 13 Z9 13 U1 3 U2 30 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1942-4302 J9 J MECH ROBOT JI J. Mech. Robot. PD MAY PY 2012 VL 4 IS 2 AR 021003 DI 10.1115/1.4005525 PG 11 WC Engineering, Mechanical; Robotics SC Engineering; Robotics GA 030UQ UT WOS:000310596000003 ER PT J AU Lin, CT McDowell, K AF Lin, Chin-Teng McDowell, Kaleb TI Prolog to the Section on Neurotechnological Systems: The Brain-Computer Interface SO PROCEEDINGS OF THE IEEE LA English DT Editorial Material C1 [Lin, Chin-Teng] Natl Chiao Tung Univ, Dept Elect Engn, Coll Elect Engn, Hsinchu, Taiwan. [Lin, Chin-Teng] Natl Chiao Tung Univ, Brain Res Ctr, Hsinchu, Taiwan. [McDowell, Kaleb] USA, Translat Neurosci Branch, Res Lab, Aberdeen Proving Ground, MD USA. [Lin, Chin-Teng] Natl Chiao Tung Univ, Dept Elect Engn, Coll Comp Sci, Hsinchu, Taiwan. [McDowell, Kaleb] USA, Neurosci Strateg Res Area, Res Lab, Aberdeen Proving Ground, MD USA. RP Lin, CT (reprint author), Natl Chiao Tung Univ, Dept Elect Engn, Coll Elect Engn, Hsinchu, Taiwan. EM ctlin@mail.nctu.edu.tw; kaleb.g.mcdowell.civ@mail.mil NR 0 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 J9 P IEEE JI Proc. IEEE PD MAY PY 2012 VL 100 SI SI BP 1551 EP 1552 DI 10.1109/JPROC.2012.2187137 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA 020TR UT WOS:000309838000040 ER PT J AU Liao, LD Lin, CT McDowell, K Wickenden, AE Gramann, K Jung, TP Ko, LW Chang, JY AF Liao, Lun-De Lin, Chin-Teng McDowell, Kaleb Wickenden, Alma E. Gramann, Klaus Jung, Tzyy-Ping Ko, Li-Wei Chang, Jyh-Yeong TI Biosensor Technologies for Augmented Brain-Computer Interfaces in the Next Decades SO PROCEEDINGS OF THE IEEE LA English DT Article DE Augmented brain-computer interface (ABCI); biosensor; cognitive-state monitoring; electroencephalogram (EEG); human brain imaging ID WIRELESS EEG SYSTEM; ELECTRICAL-STIMULATION; GENERAL FRAMEWORK; ELECTRODES; DRY; SIGNALS; DESIGN; TIME; FABRICATION; TOMOGRAPHY AB The study of brain-computer interfaces (BCIs) has undergone 30 years of intense development and has grown into a rich and diverse field. BCIs are technologies that enable direct communication between the human brain and external devices. Conventionally, wet electrodes have been employed to obtain unprecedented sensitivity to high-temporal-resolution brain activity; recently, the growing availability of various sensors that can be used to detect high-quality brain signals in a wide range of clinical and everyday environments is being exploited. This development of biosensing neurotechnologies and the desire to implement them in real-world applications have led to the opportunity to develop augmented BCIs (ABCIs) in the upcoming decades. An ABCI is similar to a BCI in that it relies on biosensors that record signals from the brain in everyday environments; the signals are then processed in real time to monitor the behavior of the human. To use an ABCI as a mobile brain imaging technique for everyday, real-life applications, the sensors and the corresponding device must be lightweight and the equipment response time must be short. This study presents an overview of the wide range of biosensor approaches currently being applied to ABCIs, from their use in the laboratory to their application in clinical and everyday use. The basic principles of each technique are described along with examples of current applications of cutting-edge neuroscience research. In summary, we show that ABCI techniques continue to grow and evolve, incorporating new technologies and advances to address ever more complex and important neuroscience issues, with advancements that are envisioned to lead to a wide range of real-life applications. C1 [Liao, Lun-De; Lin, Chin-Teng; Chang, Jyh-Yeong] Natl Chiao Tung Univ, Dept Elect Engn, Hsinchu 300, Taiwan. [Liao, Lun-De; Lin, Chin-Teng; Ko, Li-Wei] Natl Chiao Tung Univ, Brain Res Ctr, Hsinchu 300, Taiwan. [Lin, Chin-Teng] Natl Chiao Tung Univ, CS Dept, Hsinchu 300, Taiwan. [Lin, Chin-Teng] Natl Chiao Tung Univ, EE Dept, Hsinchu 300, Taiwan. [McDowell, Kaleb] USA, Translat Neurosci Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wickenden, Alma E.] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Gramann, Klaus; Jung, Tzyy-Ping] Univ Calif San Diego, Swartz Ctr Computat Neurosci, Inst Neural Computat, La Jolla, CA 92093 USA. [Ko, Li-Wei] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 300, Taiwan. RP Liao, LD (reprint author), Natl Chiao Tung Univ, Dept Elect Engn, Hsinchu 300, Taiwan. EM ctlin@mail.nctu.edu.tw FU UST-UCSD International Center of Excellence in Advanced Bio-engineering; Taiwan National Science Council I-RiCE Program [NSC-99-2911-I-010-101, NSC-100-2911-I-010-101]; National Science Council, Taiwan [NSC 100-2321-B-009-003]; National Chiao Tung University, the Ministry of Education, Taiwan [100W9633]; Army Research Laboratory [W911NF-10-2-0022] FX This work was supported in part by the UST-UCSD International Center of Excellence in Advanced Bio-engineering sponsored by the Taiwan National Science Council I-RiCE Program under Contracts NSC-99-2911-I-010-101 and NSC-100-2911-I-010-101, in part by the National Science Council, Taiwan, under Contract NSC 100-2321-B-009-003, and in part by the Aiming for the Top University Plan of National Chiao Tung University, the Ministry of Education, Taiwan, under Contract 100W9633. Research was also sponsored in part by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0022. The views and the conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U. S Government. The U. S Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 109 TC 38 Z9 39 U1 6 U2 46 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 EI 1558-2256 J9 P IEEE JI Proc. IEEE PD MAY PY 2012 VL 100 SI SI BP 1553 EP 1566 DI 10.1109/JPROC.2012.2184829 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA 020TR UT WOS:000309838000041 ER PT J AU Lance, BJ Kerick, SE Ries, AJ Oie, KS McDowell, K AF Lance, Brent J. Kerick, Scott E. Ries, Anthony J. Oie, Kelvin S. McDowell, Kaleb TI Brain-Computer Interface Technologies in the Coming Decades SO PROCEEDINGS OF THE IEEE LA English DT Article DE Augmented brain-computer interface (ABCI); brain-computer interaction; electroencephalographic (EEG); human-computer interaction; opportunistic BCI; opportunistic state detection; pervasive computing ID FUNCTIONAL MAGNETIC-RESONANCE; ERROR-RELATED NEGATIVITY; EVENT-RELATED POTENTIALS; FUSIFORM FACE AREA; NEUROIMAGING FINDINGS; WORKING-MEMORY; EEG-ANALYSIS; CORTEX; ATTENTION; PERFORMANCE AB As the proliferation of technology dramatically infiltrates all aspects of modern life, in many ways the world is becoming so dynamic and complex that technological capabilities are overwhelming human capabilities to optimally interact with and leverage those technologies. Fortunately, these technological advancements have also driven an explosion of neuroscience research over the past several decades, presenting engineers with a remarkable opportunity to design and develop flexible and adaptive brain-based neurotechnologies that integrate with and capitalize on human capabilities and limitations to improve human-system interactions. Major forerunners of this conception are brain-computer interfaces (BCIs), which to this point have been largely focused on improving the quality of life for particular clinical populations and include, for example, applications for advanced communications with paralyzed or "locked in" patients as well as the direct control of prostheses and wheelchairs. Near-term applications are envisioned that are primarily task oriented and are targeted to avoid the most difficult obstacles to development. In the farther term, a holistic approach to BCIs will enable a broad range of task-oriented and opportunistic applications by leveraging pervasive technologies and advanced analytical approaches to sense and merge critical brain, behavioral, task, and environmental information. Communications and other applications that are envisioned to be broadly impacted by BCIs are highlighted; however, these represent just a small sample of the potential of these technologies. C1 [Lance, Brent J.; Kerick, Scott E.; Ries, Anthony J.; Oie, Kelvin S.; McDowell, Kaleb] USA, Translat Neurosci Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Lance, BJ (reprint author), USA, Translat Neurosci Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM kgm8@cornell.edu RI Oie, Kelvin/J-4382-2012 NR 132 TC 50 Z9 51 U1 5 U2 44 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 EI 1558-2256 J9 P IEEE JI Proc. IEEE PD MAY PY 2012 VL 100 SI SI BP 1585 EP 1599 DI 10.1109/JPROC.2012.2184830 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 020TR UT WOS:000309838000043 ER PT J AU Supan, KE Ingley, HA Pohle, R Hahn, DW AF Supan, Karen E. Ingley, Herbert A. Pohle, Roland Hahn, David W. TI A Kinetic Model for Ammonia Adsorption on a Titanium Nitride Surface SO IEEE SENSORS JOURNAL LA English DT Article DE Chemical sensors; condition monitoring; floating-gate field effect transistors (FGFET); titanium ID FUNCTION TYPE SENSORS; NH3; SI(100)-(2X1); SYSTEM; WATER; TIN AB Recent developments aiming to microsensors based on floating gate field effect transistors (FGFET) were investigated for application in a rodent cage monitoring. Given that these sensors were on the forefront of technology, a theoretical model was developed for the ammonia sensor to further understand the chemical reaction taking place on its surface. The sensors were tested in a controlled environment, where the air quality was known. The magnitude and time of the response to different levels of ammonia were determined in the 50-100 ppm range. The reaction mechanism selected for the model which was best supported by the literature and the experiments was molecular adsorption of ammonia on a titanium nitride surface. The experimental results were fitted to the model to obtain the adsorption and desorption rate constants, the equilibrium concentration constant, equilibrium constant, and Gibb's free energy, which were 6.28 L/mol.s, 6.43 x 10(-3) s(-1), 976.7 L/mol, 39.04, and -9.25 kJ/mol, respectively. Based on these values, it was determined that the forward reaction, or adsorption, occurs spontaneously. There was good correlation between the theoretical model and the experimental results, indicating that the theoretical model was sufficient for this application. C1 [Supan, Karen E.; Ingley, Herbert A.; Hahn, David W.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Supan, Karen E.] USA, Benet Labs, Watervliet Arsenal, NY 12189 USA. [Pohle, Roland] Siemens AG, Corp Res & Technol, CT T HW2, D-81739 Munich, Germany. RP Supan, KE (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM ksupan21@yahoo.com; ingley@ufl.edu; roland.pohle@siemens.com; dwhahn@ufl.edu NR 18 TC 0 Z9 0 U1 1 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY PY 2012 VL 12 IS 5 BP 843 EP 848 DI 10.1109/JSEN.2011.2161632 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 014ZV UT WOS:000309415400001 ER PT J AU Geibel, NM Brown, CJ AF Geibel, Nicholas M. Brown, Christopher J. TI Hydraulic Fracturing of the Floridan Aquifer from Aquifer Storage and Recovery Operations SO ENVIRONMENTAL & ENGINEERING GEOSCIENCE LA English DT Article DE Aquifer Storage and Recovery; Hydraulic Fracturing; Rock Mechanics; Floridan Aquifer System; Triaxial Compressive Strength; Unconfined Compressive Strength ID FATIGUE AB Potential for hydraulically induced fracturing of the Floridan Aquifer System (FAS) and the overlying Hawthorn Group deposit exists due to operation of seven potential aquifer storage and recovery facilities planned to be developed in south-central Florida to enhance Everglades restoration. The purpose of this study was to determine critical threshold water pressures at which hydraulically induced fracturing of the FAS rock matrix may occur. Several FAS rock matrix samples were collected, tested, and evaluated to define representative mechanical properties, which were then used in relation with in situ stresses to determine critical threshold water pressures. Three hydraulically induced fracturing failure mode evaluation methods based on shear, tensile, and microfracture development were utilized. Microfracture development requires the lowest critical threshold water pressure to induce fracturing, followed by tensile and then shear failure modes. Predictive critical threshold water pressures for tensile and microfracture development failure modes can potentially be achieved during full-scale operation of the planned aquifer storage and recovery facilities; therefore, appropriate design considerations and operational precautions should be taken to minimize water pressures that exceed this operational constraint. If hydraulically induced fractures are developed in the FAS, their propagation into the Hawthorn Group deposit would likely be arrested by or re-directed along the discontinuity zone at the contact of these two deposits. Additionally, the Hawthorn Group deposit exhibits a significantly lower modulus of elasticity than the FAS, which would tend to effectively arrest hydraulically induced fracture propagation. C1 [Geibel, Nicholas M.] USA, Corps Engineers, Omaha, NE 68102 USA. [Brown, Christopher J.] Univ N Florida, Dept Civil Engn, Jacksonville, FL 32224 USA. RP Geibel, NM (reprint author), USA, Corps Engineers, 1616 Capitol Ave, Omaha, NE 68102 USA. FU U.S. Army Corps of Engineers, Jacksonville District; South Florida Water Management District FX We thank June Mirecki and Orlando Ramos-Gines of the U.S. Army Corps of Engineers, Jacksonville District, and Robert Verrastro and Emily Richardson of the South Florida Water Management District, for their support and reviews, which greatly enhanced this manuscript. Also, we would like to thank the three anonymous Environmental & Engineering Geoscience reviewers for their valuable comments that significantly improved this manuscript. NR 49 TC 1 Z9 1 U1 3 U2 23 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1078-7275 J9 ENVIRON ENG GEOSCI JI Environ. Eng. Geosci. PD MAY PY 2012 VL 18 IS 2 BP 175 EP 189 PG 15 WC Engineering, Environmental; Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 997YM UT WOS:000308204400003 ER PT J AU Switzer, CH Cheng, RYS Ridnour, LA Murray, MC Tazzari, V Sparatore, A Del Soldato, P Hines, HB Glynn, SA Ambs, S Wink, DA AF Switzer, Christopher H. Cheng, Robert Y. -S. Ridnour, Lisa A. Murray, Margaret C. Tazzari, Valerio Sparatore, Anna Del Soldato, Piero Hines, Harry B. Glynn, Sharon A. Ambs, Stefan Wink, David A. TI Dithiolethiones Inhibit NF-kappa B Activity via Covalent Modification in Human Estrogen Receptor-Negative Breast Cancer SO CANCER RESEARCH LA English DT Article ID THERAPEUTIC TARGET; HYDROGEN-SULFIDE; POOR SURVIVAL; ACTIVATION; CELLS; CHEMOPREVENTION; PROGRESSION; MODULATION; EXPRESSION; OLTIPRAZ AB The NF-kappa B transcription factor family influences breast cancer outcomes by regulating genes involved in tumor progression, angiogenesis, and metastasis. Dithiolethiones, a class of naturally occurring compounds with cancer chemoprevention effects that have become clinically available, have been found to inhibit NF-kappa B activity. However, the mechanism of this inhibition has not been identified, and the influence of dithiolethines on NF-kappa B pathway in breast cancer cells has not been examined. Here, we investigated the chemical and biochemical effects of dithiolethione on NF-kappa B and downstream effector molecules in estrogen receptor-negative breast cancer cells and murine tumor xenografts. The dithiolethiones ACS-1 and ACS-2 inhibited NF-kappa B transcriptional activity. Interestingly, this inhibition was not due to H2S release or protein phosphatase 2A activation, which are key properties of dithiolethiones, but occurred via a covalent reaction with the NF-kappa B p50 and p65 subunits to inhibit DNA binding. Dithiolethione-mediated inhibition of NF-kappa B-regulated genes resulted in the inhibition of interleukin (IL)-6, IL-8, urokinase-type plasminogen activator, and VEGF production. ACS-1 also inhibited matrix metalloproteinase-9 activity, cellular migration, and invasion, and ACS-2 reduced tumor burden and resulted in increased tumor host interactions. Together, our findings suggest that dithiolethiones show potential clinical use for estrogen negative breast cancer as a chemotherapeutic or adjuvant therapy. Cancer Res; 72(9); 2394-404. (C) 2012 AACR. C1 [Switzer, Christopher H.; Cheng, Robert Y. -S.; Ridnour, Lisa A.; Murray, Margaret C.; Glynn, Sharon A.; Wink, David A.] NCI, Radiat Biol Branch, Bethesda, MD 20892 USA. [Glynn, Sharon A.; Ambs, Stefan] NCI, Human Carcinogenesis Lab, Bethesda, MD 20892 USA. [Tazzari, Valerio; Sparatore, Anna] Univ Milan, Dipartimento Sci Farmaceut Pietro Pratesi, Milan, Italy. [Del Soldato, Piero] Sulfidris, Milan, Italy. [Hines, Harry B.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD USA. RP Wink, DA (reprint author), Bldg 10,Room B3-B35, Bethesda, MD 20892 USA. EM wink@mail.nih.gov RI Glynn, Sharon/D-7136-2013; Switzer, Christopher/D-9203-2013; Sparatore, Anna/J-8634-2015 OI Glynn, Sharon/0000-0003-1459-2580; Sparatore, Anna/0000-0003-2135-2649 FU NIH, National Cancer Institute [1ZIASC007281-16, 1ZIABC010899-02] FX This work was supported by the Intramural Research Program of the NIH, National Cancer Institute (1ZIASC007281-16 and 1ZIABC010899-02). NR 32 TC 16 Z9 16 U1 1 U2 8 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAY 1 PY 2012 VL 72 IS 9 BP 2394 EP 2404 DI 10.1158/0008-5472.CAN-11-3115 PG 11 WC Oncology SC Oncology GA 986MI UT WOS:000307345300025 PM 22436383 ER PT J AU Moran, EE Burden, R Labrie, JE Wen, ZY Wang, XM Zollinger, WD Zhang, L Pinto, VB AF Moran, Elizabeth E. Burden, Robert Labrie, Joseph E., III Wen, Zhiyun Wang, Xin-Min Zollinger, Wendell D. Zhang, Lan Pinto, Valerian B. TI Analysis of the Bactericidal Response to an Experimental Neisseria meningitidis Vesicle Vaccine SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID OUTER-MEMBRANE VESICLES; SEROGROUP-B; MENINGOCOCCAL MENINGITIS; EPIDEMIOLOGY; EXPRESSION; STRAINS; PROTEIN AB Rabbit immunogenicity studies on an experimental trivalent native outer membrane vesicle vaccine derived from three serogroup B strains were conducted to evaluate the effectiveness of this vaccine at inducing an antibody response with serum bactericidal activity against meningococcal strains of other serogroups in addition to serogroup B strains. The results showed that the vaccine was capable of inducing an effective broad-based bactericidal antibody response in rabbits against a small sample of Neisseria meningitidis strains of serogroups C, W135, and X and, to a lesser extent, serogroups A and Y. Analysis of antibody specificity using a bactericidal depletion assay revealed that antibodies to lipooligosaccharide (LOS), PorA, and NadA induced in rabbits by the experimental trivalent outer membrane vesicle vaccine were responsible for most of the bactericidal activity against strains of the other N. meningitidis serogroups. In the case of serogroup A N. meningitidis strains, the outer membrane antigen NadA was primarily responsible for protection. The outer membrane antigens fHbp and OpcA were also effective in removing some bactericidal activity from the sera. C1 [Moran, Elizabeth E.; Burden, Robert; Labrie, Joseph E., III; Zollinger, Wendell D.; Pinto, Valerian B.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Wen, Zhiyun; Wang, Xin-Min; Zhang, Lan] Merck Res Labs, Vaccine Basic Res, West Point, PA USA. RP Pinto, VB (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. EM valerian.pinto@us.army.mil FU Military Infectious Disease Research Program Office of USAMRMC, U.S. Army FX Funding for the work described in this paper was provided by the Military Infectious Disease Research Program Office of USAMRMC, U.S. Army. NR 34 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2012 VL 19 IS 5 BP 659 EP 665 DI 10.1128/CVI.00070-12 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 983GU UT WOS:000307108600005 PM 22461527 ER PT J AU Ngundi, MM Meade, BD Little, SF Quinn, CP Corbett, CR Brady, RA Burns, DL AF Ngundi, Miriam M. Meade, Bruce D. Little, Stephen F. Quinn, Conrad P. Corbett, Cindi R. Brady, Rebecca A. Burns, Drusilla L. TI Analysis of Defined Combinations of Monoclonal Antibodies in Anthrax Toxin Neutralization Assays and Their Synergistic Action SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; LETHAL TOXIN; IN-VITRO; INHALATIONAL ANTHRAX; RHESUS MACAQUES; FC-RECEPTORS; GUINEA-PIGS; VACCINE; IMMUNITY AB Antibodies against the protective antigen (PA) component of anthrax toxin play an important role in protection against disease caused by Bacillus anthracis. In this study, we examined defined combinations of PA-specific monoclonal antibodies for their ability to neutralize anthrax toxin in cell culture assays. We observed additive, synergistic, and antagonistic effects of the antibodies depending on the specific antibody combination examined and the specific assay used. Synergistic toxin-neutralizing antibody interactions were examined in more detail. We found that one mechanism that can lead to antibody synergy is the bridging of PA monomers by one antibody, with resultant bivalent binding of the second antibody. These results may aid in optimal design of new vaccines and antibody therapies against anthrax. C1 [Ngundi, Miriam M.; Brady, Rebecca A.; Burns, Drusilla L.] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA. [Little, Stephen F.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Meade, Bruce D.] Meade Biol, Hillsborough, NC USA. [Quinn, Conrad P.] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp Dis, Atlanta, GA USA. [Corbett, Cindi R.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada. RP Burns, DL (reprint author), US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA. EM drusilla.burns@fda.hhs.gov FU National Institute of Allergy and Infectious Diseases, NIH; Food and Drug Administration FX This work was supported in part by an interagency agreement between the National Institute of Allergy and Infectious Diseases, NIH, and the Food and Drug Administration. NR 42 TC 9 Z9 9 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2012 VL 19 IS 5 BP 731 EP 739 DI 10.1128/CVI.05714-11 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 983GU UT WOS:000307108600014 PM 22441391 ER PT J AU Blacksell, SD Jarman, RG Gibbons, RV Tanganuchitcharnchai, A Mammen, MP Nisalak, A Kalayanarooj, S Bailey, MS Premaratna, R de Silva, HJ Day, NPJ Lalloo, DG AF Blacksell, Stuart D. Jarman, Richard G. Gibbons, Robert V. Tanganuchitcharnchai, Ampai Mammen, Mammen P., Jr. Nisalak, Ananda Kalayanarooj, Siripen Bailey, Mark S. Premaratna, Ranjan de Silva, H. Janaka Day, Nicholas P. J. Lalloo, David G. TI Comparison of Seven Commercial Antigen and Antibody Enzyme-Linked Immunosorbent Assays for Detection of Acute Dengue Infection SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID VIRUS-INFECTION; NS1 ANTIGEN; EARLY-DIAGNOSIS; RAPID TEST; ACCURACY; SENSITIVITY; TESTS; ELISA; SPECIFICITY; SAMPLES AB Seven commercial assays were evaluated to determine their suitability for the diagnosis of acute dengue infection: (i) the Panbio dengue virus Pan-E NS1 early enzyme-linked immunosorbent assay (ELISA), second generation (Alere, Australia); (ii) the Panbio dengue virus IgM capture ELISA (Alere, Australia); (iii) the Panbio dengue virus IgG capture ELISA (Alere, Australia); (iv) the Standard Diagnostics dengue virus NS1 antigen ELISA (Standard Diagnostics, South Korea); (v) the Standard Diagnostics dengue virus IgM ELISA (Standard Diagnostics, South Korea); (vi) the Standard Diagnostics dengue virus IgG ELISA (Standard Diagnostics, South Korea); and (vii) the Platelia NS1 antigen ELISA (Bio-Rad, France). Samples from 239 Thai patients confirmed to be dengue virus positive and 98 Sri Lankan patients negative for dengue virus infection were tested. The sensitivities and specificities of the NS1 antigen ELISAs ranged from 45 to 57% and 93 to 100% and those of the IgM antibody ELISAs ranged from 85 to 89% and 88 to 100%, respectively. Combining the NS1 antigen and IgM antibody results from the Standard Diagnostics ELISAs gave the best compromise between sensitivity and specificity (87 and 96%, respectively), as well as providing the best sensitivity for patients presenting at different times after fever onset. The Panbio IgG capture ELISA correctly classified 67% of secondary dengue infection cases. This study provides strong evidence of the value of combining dengue virus antigen-and antibody-based test results in the ELISA format for the diagnosis of acute dengue infection. C1 [Blacksell, Stuart D.; Tanganuchitcharnchai, Ampai; Day, Nicholas P. J.] Mahidol Univ, Fac Trop Med, Mahidol Univ Oxford Trop Med Res Unit MORU, Bangkok, Thailand. [Blacksell, Stuart D.; Day, Nicholas P. J.] Univ Oxford, Churchill Hosp, Ctr Trop Med, Oxford, England. [Jarman, Richard G.; Gibbons, Robert V.; Mammen, Mammen P., Jr.; Nisalak, Ananda] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand. [Bailey, Mark S.] Royal Ctr Def Med, Dept Mil Med, Birmingham, W Midlands, England. [Premaratna, Ranjan; de Silva, H. Janaka] Univ Kelaniya, Fac Med, Dept Med, Ragama, Sri Lanka. [Lalloo, David G.] Univ Liverpool, Liverpool Sch Trop Med, Clin Res Grp, Liverpool L3 5QA, Merseyside, England. RP Blacksell, SD (reprint author), Mahidol Univ, Fac Trop Med, Mahidol Univ Oxford Trop Med Res Unit MORU, Bangkok, Thailand. EM stuart@tropmedres.ac RI Bailey, Mark/D-3854-2013; OI Bailey, Mark/0000-0003-4840-5093; Blacksell, Stuart/0000-0001-6576-726X FU Wellcome Trust of Great Britain; UK Defense Postgraduate Medical Deanery; University of Kelaniya, Sri Lanka FX The study was funded by grants from the Wellcome Trust of Great Britain, the UK Defense Postgraduate Medical Deanery, and the University of Kelaniya, Sri Lanka. There are no personal conflicts of interest. NR 26 TC 51 Z9 54 U1 1 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2012 VL 19 IS 5 BP 804 EP 810 DI 10.1128/CVI.05717-11 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 983GU UT WOS:000307108600025 PM 22441389 ER PT J AU Waag, DM England, MJ DeShazer, D AF Waag, David M. England, Marilyn J. DeShazer, David TI Humoral Immune Responses in a Human Case of Glanders SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; Q-FEVER; BURKHOLDERIA-PSEUDOMALLEI; SERODIAGNOSIS; MALLEI; HORSES AB Within 2 months of acquiring glanders, a patient developed 8-, 16-, and 4-fold increases, respectively, in specific IgA, IgG, and IgM serological titers against Burkholderia mallei. Within 14 months of infection, the titers decreased to the baseline. Serum from this patient was also highly reactive against Burkholderia pseudomallei whole cells. Burkholderia mallei whole cells did not react with sera from patients with other diseases. Therefore, an assay using a B. mallei cellular diagnostic antigen may be useful for the serodiagnosis of glanders. C1 [Waag, David M.; England, Marilyn J.; DeShazer, David] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Waag, DM (reprint author), USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. EM david.waag@amedd.army.mil FU Defense Threat Reduction Agency [1.1A0001_09_RD_B] FX This effort was funded by the Defense Threat Reduction Agency, project number 1.1A0001_09_RD_B. NR 18 TC 2 Z9 2 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2012 VL 19 IS 5 BP 814 EP 816 DI 10.1128/CVI.05567-11 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 983GU UT WOS:000307108600027 PM 22398248 ER PT J AU Schmaljohn, CS AF Schmaljohn, Connie S. TI Vaccines for hantaviruses: progress and issues SO EXPERT REVIEW OF VACCINES LA English DT Editorial Material DE hantavirus pulmonary syndrome; hantaviruses; hemorrhagic fever with renal syndrome; vaccines ID HANTAAN-VIRUS-VACCINE; PULMONARY SYNDROME; PUUMALA-VIRUS; PROTECTS HAMSTERS; DISEASE C1 USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@amedd.army.mil NR 19 TC 12 Z9 13 U1 0 U2 3 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2012 VL 11 IS 5 BP 511 EP 513 DI 10.1586/ERV.12.15 PG 3 WC Immunology SC Immunology GA 975WM UT WOS:000306542200001 PM 22827236 ER PT J AU Gates, DH Dingwell, JB Scott, SJ Sinitski, EH Wilken, JM AF Gates, Deanna H. Dingwell, Jonathan B. Scott, Shawn J. Sinitski, Emily H. Wilken, Jason M. TI Gait characteristics of individuals with transtibial amputations walking on a destabilizing rock surface SO GAIT & POSTURE LA English DT Article DE Transtibial amputation; Uneven or irregular terrain; Kinematics; Falls; Walking ID HUMAN JOINT MOTION; DYNAMIC STABILITY; STAIR AMBULATION; BIOMECHANICAL ANALYSIS; ISB RECOMMENDATION; HEALTHY-YOUNG; TOE CLEARANCE; AMPUTEE GAIT; STRATEGIES; ADULTS AB Individuals with transtibial amputation (TTA) have a high incidence of falls during walking. Environmental factors, such as uneven ground, often play a contributing role in these falls. The purpose of this study was to quantify the adaptations TTA made when walking on a destabilizing loose rock surface. In this study, 13 young TTA walked over a rock surface and level ground at four controlled speeds. Subjects successfully traversed the rock surface by adopting a conservative gait characterized by shorter and wider steps. They also took shorter steps with their prosthetic limbs and exhibited greater variability in foot placement when stepping onto their intact limb. Between-limb differences in step length and width variability increased at faster walking speeds. TTA increased hip and knee flexion during initial stance, which contributed lowering the whole-body center of mass. TTA also increased hip and knee flexion during swing, enabling them to significantly increase their toe clearance on the rock surface compared to level ground. Toe clearance on the prosthetic side was aided by increased ipsilateral hip flexion. The results suggest that TTA were able to adapt their gait to overcome the challenge imposed by the rock surface. These adaptations were asymmetric and initiated proximally. (C) 2012 Elsevier B.V. All rights reserved. C1 [Gates, Deanna H.; Sinitski, Emily H.; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Scott, Shawn J.] Moncrief Army Community Hosp, Ft Jackson, SC 29207 USA. RP Gates, DH (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM deanna.h.gates@gmail.com OI Dingwell, Jonathan/0000-0001-6990-4153; Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program; US Army Medical Specialty Corps Long-Term Health Education Training Fellowship; NIH [1-R01-HD059844-01A1] FX Partial support was provided by the Military Amputee Research Program (to JMW), a US Army Medical Specialty Corps Long-Term Health Education Training Fellowship (to SJS), and NIH grant 1-R01-HD059844-01A1 (to JBD). NR 33 TC 18 Z9 19 U1 0 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 J9 GAIT POSTURE JI Gait Posture PD MAY PY 2012 VL 36 IS 1 BP 33 EP 39 DI 10.1016/j.gaitpost.2011.12.019 PG 7 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 974PP UT WOS:000306449100006 PM 22469772 ER PT J AU Lazarus, A Massoumi, A Hostler, J Hostler, DC AF Lazarus, Angeline Massoumi, Ali Hostler, Jordanna Hostler, David C. TI Asbestos-Related Pleuropulmonary Diseases: Benign and Malignant SO POSTGRADUATE MEDICINE LA English DT Article DE asbestos; pleuropulmonary disease; lung cancer; asbestosis; pleural effusion; pleural thickening ID MODULATED RADIATION-THERAPY; LUNG-CANCER; PLEURAL MESOTHELIOMA; EXTRAPLEURAL PNEUMONECTOMY; ROUNDED ATELECTASIS; EXPOSED WORKERS; FLEISCHNER-SOCIETY; OSTEOPONTIN LEVELS; CIGARETTE-SMOKING; GENE-THERAPY AB Asbestos is known for its desirable properties of thermal and heat resistance along with excellent strength and durability. It was widely used in many industries since the late 19th century, until its adverse effects on health were recognized. The occurrence of pleuropulmonary changes from exposure to asbestos often has a latency period of 20 to 30 years. The use of asbestos has been banned, regulated, and minimized in many countries, but in several developing countries, the use of asbestos in industries is still a common practice. In this article, the benign and malignant clinical manifestations of asbestos exposure are discussed. C1 [Lazarus, Angeline; Massoumi, Ali; Hostler, Jordanna] Walter Reed Natl Mil Med Ctr, Div Pulm, Bethesda, MD 20889 USA. [Hostler, David C.] Tripler Army Med Ctr, Dept Internal Med, Honolulu, HI 96859 USA. RP Lazarus, A (reprint author), Walter Reed Natl Mil Med Ctr, Div Pulm, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM angeline.lazarus@med.navy.mil NR 142 TC 1 Z9 1 U1 0 U2 4 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD MAY PY 2012 VL 124 IS 3 BP 116 EP 130 DI 10.3810/pgm.2012.05.2555 PG 15 WC Medicine, General & Internal SC General & Internal Medicine GA 983FH UT WOS:000307103800014 PM 22691906 ER PT J AU Kerfoot, WC Yousef, F Green, SA Regis, R Shuchman, R Brooks, CN Sayers, M Sabol, B Graves, M AF Kerfoot, W. Charles Yousef, Foad Green, Sarah A. Regis, Robert Shuchman, Robert Brooks, Colin N. Sayers, Mike Sabol, Bruce Graves, Mark TI Light detection and ranging (LiDAR) and multispectral studies of disturbed Lake Superior coastal environments SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Article ID MINE TAILINGS; KEWEENAW CURRENT; COPPER MINE; TOXICITY TESTS; NORTHERN CHILE; SEDIMENTS; WATER; PENINSULA; COMMUNITY; TRANSPORT AB Due to its high spatial resolution and excellent water penetration, coastal light detection and ranging (LiDAR) coupled with multispectral imaging (MSS) has great promise for resolving shoreline features in the Great Lakes. Previous investigations in Lake Superior documented a metal-rich "halo" around the Keweenaw Peninsula, related to past copper mining practices. Grand Traverse Bay on the Keweenaw Peninsula provides an excellent Great Lakes example of global mine discharges into coastal environments. For more than a century, waste rock migrating from shoreline tailings piles has moved along extensive stretches of coast, damming stream outlets, intercepting wetlands and recreational beaches, suppressing benthic invertebrate communities, and threatening critical fish breeding grounds. In the bay, the magnitude of the discarded wastes literally "reset the shoreline" and provided an intriguing field experiment in coastal erosion and spreading environmental effects. Employing a combination of historic aerial photography and LiDAR, we estimate the time course and mass of tailings eroded into the bay and the amount of copper that contributed to the metal-rich halo. We also quantify underwater tailings spread across benthic substrates by using MSS imagery on spectral reflectance differences between tailings and natural sediment types, plus a depth-correction algorithm (Lyzenga Method). We show that the coastal detail from LiDAR and MSS opens up numerous applications for ecological, ecosystem, and geological investigations. C1 [Kerfoot, W. Charles; Yousef, Foad] Michigan Technol Univ, Lake Super Ecosyst Res Ctr, Houghton, MI 49931 USA. [Kerfoot, W. Charles; Yousef, Foad] Michigan Technol Univ, Dept Biol Sci, Houghton, MI 49931 USA. [Green, Sarah A.] Michigan Technol Univ, Dept Chem, Houghton, MI 49931 USA. [Regis, Robert; Shuchman, Robert] Michigan Technol Univ, Dept Geol & Min Engn & Sci, Houghton, MI 49931 USA. [Shuchman, Robert; Brooks, Colin N.; Sayers, Mike] Michigan Tech Res Inst, Ann Arbor, MI USA. [Sabol, Bruce; Graves, Mark] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Kerfoot, WC (reprint author), Michigan Technol Univ, Lake Super Ecosyst Res Ctr, Houghton, MI 49931 USA. EM wkerfoot@mtu.edu OI Green, Sarah/0000-0002-8094-433X FU Army Corps of Engineers ERDC-EL laboratory; National Science Foundation, Ocean Sciences [97-12872]; U.S. Environmental Protection Agency Region V Grant; Compact Hydrographic Airborne Rapid Total Survey (CHARTS) FX The LiDAR project was a collaborative effort between Bruce Sabol and Mark Graves at the Engineer Research and Development Center-Environmental Laboratory (ERDC-EL, Vicksburg, Mississippi), the Joint Airborne LiDAR Bathymetry Technical Center of Expertise (JALBTCX, Kiln, Mississippi), Detroit District Corps of Engineers, faculty and students from Biological Sciences, Chemistry, and Geological Engineering, Mining and Sciences at Michigan Technological University (Michigan Tech, Houghton, Michigan), and research scientists at Michigan Technological Research Center (MTRI; Ann Arbor, Michigan). Primary funding came from the Army Corps of Engineers ERDC-EL laboratory and was provided by the System Wide Water Resources Program (Steve Ashby, program manager) at Vicksburg. Efforts were also aided by a National Science Foundation, Ocean Sciences 97-12872 grant to W.C.K., and a U.S. Environmental Protection Agency Region V Grant to the Baraga Tribal Council passed through to W.C.K. Support for the Compact Hydrographic Airborne Rapid Total Survey (CHARTS) flight and initial data processing was provided by the Corps National Coastal Mapping Program managed by Jennifer Wozencraft at the JALBTCX Center. We also thank Mike Donofrio, Mike Sladewski, Esteban Chiriboga, and especially J. Biberhofer for sharing details of the National Water Research Institute and Great Lakes Indian Fish and Wildlife Commission sonar mapping and sediment sampling efforts in Grand Traverse Bay. Lucille Zelazny aided preparation of figures, and Jamey Anderson sieved stamp sand samples. NR 68 TC 5 Z9 5 U1 3 U2 26 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0024-3590 EI 1939-5590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD MAY PY 2012 VL 57 IS 3 BP 749 EP 771 DI 10.4319/lo.2012.57.3.0749 PG 23 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA 971XJ UT WOS:000306239300007 ER PT J AU Myers, TM Sun, W Naik, RS Clark, MG Doctor, BP Saxena, A AF Myers, Todd M. Sun, Wei Naik, Ramachandra S. Clark, Matthew G. Doctor, Bhupendra P. Saxena, Ashima TI Characterization of human serum butyrylcholinesterase in rhesus monkeys: Behavioral and physiological effects SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE Human serum butyrylcholinesterase; Rhesus monkeys; Pharmacokinetics; Anti-BChE antibody; Clinical blood pathology; Serial probe recognition task ID PROBE RECOGNITION TASK; NERVE AGENT TOXICITY; ACETYLCHOLINESTERASE PROPHYLAXIS; MACACA-MULATTA; GUINEA-PIGS; ORGANOPHOSPHATE TOXICITY; PRETREATMENT DRUGS; RAT-BRAIN; SOMAN; PROTECTION AB The effects of a large dose of human serum butyrylcholinesterase (HuBChE) were evaluated in rhesus monkeys using a serial-probe recognition (SPR) task designed to assess attention and short-term memory. Each monkey received an intravenous injection of 150 mg (105,000 U or 30 mg/kg) of HuBChE 60 min prior to testing on the SPR task. Concurrent with the cognitive-behavioral assessment, blood was collected at various time points throughout the study and was analyzed for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities, anti-BChE antibody production and gross clinical pathology (i.e., complete blood count and clinical chemistry panel). HuBChE revealed a peak blood activity of 227 U/ml at 5 min after intravenous injection and a mean residence time of approximately 72 h. No cognitive-behavioral decrements of any kind in SPR performance and no toxic signs in clinical pathology were detected in any of the blood assays during the 5 weeks of observation. Anti-HuBChE antibodies peaked at about 14 days after injection, with no concomitant behavioral changes. These results demonstrate the behavioral and physiological safety of HuBChE in rhesus monkeys and support its development as a bioscavenger for the prophylaxis of chemical warfare agent toxicity in humans. Published by Elsevier Inc. C1 [Myers, Todd M.; Clark, Matthew G.] Walter Reed Army Inst Res, Div Neurosci, Silver Spring, MD 20910 USA. [Sun, Wei; Naik, Ramachandra S.; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Myers, TM (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM todd.myers2@us.army.mil; ashima.saxena@us.army.mil NR 49 TC 10 Z9 11 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0892-0362 EI 1872-9738 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAY-JUN PY 2012 VL 34 IS 3 BP 323 EP 328 DI 10.1016/j.ntt.2012.02.002 PG 6 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA 970QE UT WOS:000306146600004 PM 22402122 ER PT J AU Woo, HJ Satya, RV Reifman, J AF Woo, Hyung-June Satya, Ravi Vijaya Reifman, Jaques TI Thermodynamic Basis for the Emergence of Genomes during Prebiotic Evolution SO PLOS COMPUTATIONAL BIOLOGY LA English DT Article ID SULFOLOBUS-SOLFATARICUS P2; ISING QUANTUM CHAIN; DNA-POLYMERASE; BIOLOGICAL EVOLUTION; ERROR CATASTROPHE; POLIOVIRUS RNA; FIDELITY; REPLICATION; ORIGIN; MODEL AB The RNA world hypothesis views modern organisms as descendants of RNA molecules. The earliest RNA molecules must have been random sequences, from which the first genomes that coded for polymerase ribozymes emerged. The quasispecies theory by Eigen predicts the existence of an error threshold limiting genomic stability during such transitions, but does not address the spontaneity of changes. Following a recent theoretical approach, we applied the quasispecies theory combined with kinetic/thermodynamic descriptions of RNA replication to analyze the collective behavior of RNA replicators based on known experimental kinetics data. We find that, with increasing fidelity (relative rate of base-extension for Watson-Crick versus mismatched base pairs), replications without enzymes, with ribozymes, and with protein-based polymerases are above, near, and below a critical point, respectively. The prebiotic evolution therefore must have crossed this critical region. Over large regions of the phase diagram, fitness increases with increasing fidelity, biasing random drifts in sequence space toward `crystallization.' This region encloses the experimental nonenzymatic fidelity value, favoring evolutions toward polymerase sequences with ever higher fidelity, despite error rates above the error catastrophe threshold. Our work shows that experimentally characterized kinetics and thermodynamics of RNA replication allow us to determine the physicochemical conditions required for the spontaneous crystallization of biological information. Our findings also suggest that among many potential oligomers capable of templated replication, RNAs may have evolved to form prebiotic genomes due to the value of their nonenzymatic fidelity. C1 [Woo, Hyung-June; Satya, Ravi Vijaya; Reifman, Jaques] USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. RP Woo, HJ (reprint author), USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. EM jaques.reifman@us.army.mil FU Military Operational Medicine Research Program of the U.S. Army Medical Research and Material Command, Fort Detrick, Maryland under the U.S. Army's Network Science Initiative FX This work was funded by the Military Operational Medicine Research Program of the U.S. Army Medical Research and Material Command, Fort Detrick, Maryland under the U.S. Army's Network Science Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 63 TC 2 Z9 2 U1 0 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1553-7358 J9 PLOS COMPUT BIOL JI PLoS Comput. Biol. PD MAY PY 2012 VL 8 IS 5 AR e1002534 DI 10.1371/journal.pcbi.1002534 PG 18 WC Biochemical Research Methods; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Mathematical & Computational Biology GA 968GF UT WOS:000305964600038 PM 22693440 ER PT J AU Koissi, N Shah, NH Ginevan, B Eck, WS Roebuck, BD Fishbein, JC AF Koissi, Niangoran Shah, Niti H. Ginevan, Brandon Eck, William S. Roebuck, Bill D. Fishbein, James C. TI Lactone Metabolite Common to the Carcinogens Dioxane, Diethylene Glycol, and N-Nitrosomorpholine: Aqueous Chemistry and Failure to Mediate Liver Carcinogenesis in the F344 Rat SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID GLUCONO-DELTA-LACTONE; AFLATOXIN-INDUCED TUMORIGENESIS; MAJOR URINARY METABOLITE; HEPATIC TUMORIGENESIS; MOLECULAR DOSIMETRY; OLTIPRAZ; HYDROLYSIS; PROTECTION; CANCER; ACID AB 1,4-Dioxan-2-one, 1, was synthesized, and the equilibrium constant between it and the hydrolysis product 2-(2-hydroxyethoxy) acetic acid, 2, was determined as K-O = 70 +/- 4 in acidic aqueous media, 25 degrees C, ionic strength 1 M (KCI), and 5% by volume acetonitrile. The carboxylic acid dissociation constant of 2 was determined under the same conditions to be pK(a) = 3.31 +/- 0.02. On the basis of these two determinations, the equilibrium constant between 1 and carboxylic acid anion, 3, and the proton was calculated to be K-OA = 0.034 +/- 0.002 M. The stability of 1 was determined in the range of pH between 1 and 8.5 in buffered aqueous solutions under the conditions above by UV spectrophotometric methods and exhibited simple first order kinetics of decay. On the basis of buffer dilution plots, the values of k(o,) the rate constant for solvent mediated decomposition, were determined. The plot of log ko against pH is consistent with a three term rate law for solvolysis with a hydrogen ion catalyzed rate constant k(H+) = 1.1 (+/- 0.1) M-1 min(-1), a water catalyzed rate constant, k(w) = 9.9 (+/- 0.5) x 10(-4) min(-1), and a hydroxide ion catalyzed rate constant, k(OH) = 4.1 (+/- 0.3) x 10(4) M-1 min(-1)The t(1/2) for decay at pH 7.0, at 25 degrees C, is similar to 2 h. Treatment of F344 rats with aflatoxin B-1 (AFB(1)) (positive control) elicited the expected preneoplastic foci in the livers of each rat tested, while subsequent administration of 1 (a total of 1.32 g over 12 weeks) failed to statistically increase focal number or focal volume percent. In 8 rats administered 1 (1.32 g, 12 weeks) alone, no increase above background foci was detected. This study does not support compound 1 as a common carcinogen. C1 [Roebuck, Bill D.] Dartmouth Med Sch, Dept Pharmacol & Toxicol, Hanover, NH 03755 USA. [Koissi, Niangoran; Shah, Niti H.; Ginevan, Brandon; Fishbein, James C.] Univ Maryland Baltimore Cty, Dept Chem & Biochem, Baltimore, MD 21250 USA. [Eck, William S.] USA, Hlth Effects Res Program, Army Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Roebuck, BD (reprint author), Dartmouth Med Sch, Dept Pharmacol & Toxicol, Hanover, NH 03755 USA. EM Bill.D.Roebuck@dartmouth.edu; jfishbei@umbc.edu FU NIH [R01 CA52881, R01 CA 39416]; Aberdeen Proving Ground [W91ZLK-08-P-1038] FX This work was supported in part by NIH grant R01 CA52881 (to J.C.F.), Aberdeen Proving Ground contract W91ZLK-08-P-1038 (to J.C.F.), and NIH grant R01 CA 39416 (to B.D.R.). NR 44 TC 1 Z9 1 U1 2 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD MAY PY 2012 VL 25 IS 5 BP 1022 EP 1028 DI 10.1021/tx3000076 PG 7 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 944WR UT WOS:000304235000006 PM 22458541 ER PT J AU Kuehn, JT AF Kuehn, John T. TI The British Pacific Fleet: The Royal Navy's most powerful strike force SO MARINERS MIRROR LA English DT Book Review C1 [Kuehn, John T.] USA, Command & Gen Staff Coll, Washington, DC USA. RP Kuehn, JT (reprint author), USA, Command & Gen Staff Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC NAUTICAL RESEARCH PI LONDON PA NATIONAL MARITIME MUSEUM GREENWICH, LONDON SE10 9NF, ENGLAND SN 0025-3359 J9 MARINERS MIRROR JI Mar. Mirror PD MAY PY 2012 VL 98 IS 2 BP 244 EP 245 PG 2 WC History SC History GA 955PS UT WOS:000305034000041 ER PT J AU Teerasut, C Lei, HY Natthakorn, K Jittmittraphap, A Thammapalo, S Witayathawornwong, P Lin, YT Jarman, RG Sawanpanyalert, P Jampangern, W Limkittikul, K AF Teerasut, Chai Lei, Huan-Yao Natthakorn, Khuendee Jittmittraphap, Akanitt Thammapalo, Suwich Witayathawornwong, Prasong Lin, Ya-Tin Jarman, Richard G. Sawanpanyalert, Pathom Jampangern, Wipawee Limkittikul, Kriengsak TI THE SEROTYPE-INDEPENDENT BUT CONCENTRATION-DEPENDENT ENHANCING ANTIBODIES AMONG THAI DENGUE PATIENTS SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE anti-dengue antibody; concentration; serotype; DF; DHF ID HEMORRHAGIC-FEVER; JAPANESE ENCEPHALITIS; VIRUS-INFECTION; DV INFECTION; ENHANCEMENT; PATHOGENESIS; MONOCYTES; SEVERITY; VIREMIA; DISEASE AB Antibody-dependent enhancement of infection (ADE) is central to explaining the development of severe disease at the end of post-dengue virus infection. Non-neutralizing anti-dengue antibodies bound to the dengue virion enhances the virus entrance into the target cells via the Fc receptor. The titer of enhancing antibodies in dengue patients is not determined during dengue virus infection. Sensitive flow cytometry detecting dengue virus-infected K562 cells was used to quantitate enhancing activity among Thai DF and DHF patients against four serotypes and the patient's dengue isolate. The titer was defined as the reciprocal of the final dilution that loses enhancing activity. The serum of Thai patients confirmed to have dengue infection were found to have high titers of enhancing antibodies and increased gradually through the convalescent phase of infection. The enhancing antibody titers were not different among the four serotypes or from the infecting isolate. The anti-dengue antibodies from dengue patients can enhance dengue virus infections in a concentration-dependent, serotype-independent manner. C1 [Limkittikul, Kriengsak] Mahidol Univ, Fac Trop Med, Dept Trop Pediat, Bangkok 10400, Thailand. [Lei, Huan-Yao; Lin, Ya-Tin] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan. [Natthakorn, Khuendee; Jittmittraphap, Akanitt; Jampangern, Wipawee] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, Bangkok, Thailand. [Thammapalo, Suwich] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Witayathawornwong, Prasong] Phetchabun Prov Hosp, Minist Publ Hlth, Off Permanent Secretary, Phetchabun, Thailand. [Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Sawanpanyalert, Pathom] Minist Publ Hlth, Dept Med Sci, Nonthaburi, Thailand. RP Limkittikul, K (reprint author), Mahidol Univ, Fac Trop Med, Dept Trop Pediat, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM hylei@mail.ncku.edu.tw; tmklk@mahidol.ac.th FU Department of Disease Control, Ministry of Public Health; National Health Research Institute [NHRI-CN-CL9601S]; National Science Council, Taiwan, Republic of China [NSC95-3112-B006-004]; Mahidol University, Thailand FX This work was supported by a grant from the Department of Disease Control, Ministry of Public Health and Mahidol University, Thailand, grant NHRI-CN-CL9601S from the National Health Research Institute, and NSC95-3112-B006-004 from the National Science Council, Taiwan, Republic of China. We thank Dr Mammen P Mammen Jr, Dr Robert V Gibbon, Dr Ananda Nisalak and the Virology Department Members, AFRIMS, for their expert advice and encouragement. We also thank all the doctors, nurses and medical technicians at Phetchabun, Nakhon Si Thammarat and Si Sa Ket Provincial Hospitals, and Dr Kao-Jean Huang for the preparation of the figures. NR 19 TC 2 Z9 2 U1 1 U2 2 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAY PY 2012 VL 43 IS 3 BP 624 EP 633 PG 10 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 957MY UT WOS:000305168300010 PM 23077841 ER PT J AU Mitchell, DC Niu, SL Litman, BJ AF Mitchell, Drake C. Niu, Shui-Lin Litman, Burton J. TI Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction SO CHEMISTRY AND PHYSICS OF LIPIDS LA English DT Article DE Docosahexaenoic acid; Docosapentaenoic acid; Rhodopsin; GPCR; Visual signal transduction ID ROD OUTER SEGMENT; CHAIN PHOSPHATIDYLCHOLINE VESICLES; PROTEIN-COUPLED RECEPTORS; FATTY-ACID COMPOSITION; HIGHER-ORDER ANALYSIS; METARHODOPSIN-II; DOCOSAHEXAENOIC ACID; BOVINE RHODOPSIN; DISK MEMBRANES; PHOTORECEPTOR-MEMBRANES AB A range of evidence from animal, clinical and epidemiological studies indicates that highly polyunsaturated acyl chains play important roles in development, cognition, vision and other aspects of neurological function. In a number of these studies n3 polyunsaturated fatty acids (PUFAs) appear to be more efficacious than n6 PUFAs. In a previous study of retinal rod outer segments obtained from rats raised on either an n3 adequate or deficient diet, we demonstrated that the replacement of 22:6n3 by 22:5n6 in the n3 deficient rats led to functional deficits in each step in the visual signaling process (Niu et al., 2004). In this study, we examined rhodopsin and phosphodiesterase function and acyl chain packing properties in membranes consisting of phosphatidylcholines with sn-1 = 18:0, and sn-2 = 22:6n3. 22:5n6, or 22:5n3 in order to determine if differences in function are due to the loss of one double bond or due to differences in double bond location. At 37 degrees C the n6 lipid shifted the equilibrium between the active metarhodopsin II (MII) state and inactive metarhodopsin I (MI) state towards MI. In addition, 22:5n6 reduced the rates of MII formation and MII-transducin complex formation by 2- and 6-fold, respectively. At a physiologically relevant level of rhodopsin light stimulation, the activity of phosphodiesterase was reduced by 50% in the 22:5n6 membrane, relative to either of the n3 membranes. Activity levels in the two n3 membranes were essentially identical. Ensemble acyl chain order was assessed with time-resolved fluorescence measurements of the membrane probe diphenylhexatriene (DPH). Analysis in terms of the orientational distribution of DPH showed that acyl chain packing in the two n3 membranes is quite similar, while in the 22:5n6 membrane there was considerably less packing disorder in the bilayer midplane. These results demonstrate that the n3 bond configuration uniquely optimizes the early steps in signaling via a mechanism which may involve acyl chain packing deep in the bilayer. (C) 2012 Elsevier Ireland Ltd. All rights reserved. C1 [Mitchell, Drake C.] Portland State Univ, Dept Phys, Portland, OR 97201 USA. [Niu, Shui-Lin] USA, Congress Directed Med Res Programs, Med Res & Mat Command, Dept Def, Frederick, MD 21702 USA. [Litman, Burton J.] NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD USA. RP Mitchell, DC (reprint author), Portland State Univ, Dept Phys, POB 751, Portland, OR 97201 USA. EM drakem@pdx.edu; shui-lin.niu@amedd.army.mil; blitman@bendbroadband.com NR 54 TC 12 Z9 12 U1 1 U2 16 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-3084 J9 CHEM PHYS LIPIDS JI Chem. Phys. Lipids PD MAY PY 2012 VL 165 IS 4 SI SI BP 393 EP 400 DI 10.1016/j.chemphyslip.2012.02.008 PG 8 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 952LL UT WOS:000304793900006 PM 22405878 ER PT J AU Edwards, CE Ewers, BE McClung, CR Lou, P Weinig, C AF Edwards, Christine E. Ewers, Brent E. McClung, C. Robertson Lou, Ping Weinig, Cynthia TI Quantitative Variation in Water-Use Efficiency across Water Regimes and Its Relationship with Circadian, Vegetative, Reproductive, and Leaf Gas-Exchange Traits SO MOLECULAR PLANT LA English DT Article DE Brassica rapa; drought; ecophysiology; floral traits; G matrix; leaf gas-exchange traits; water-use efficiency; vegetative traits ID CARBON-ISOTOPE DISCRIMINATION; GENOTYPE-ENVIRONMENT INTERACTION; ARABIDOPSIS-THALIANA; GENETIC CONSTRAINTS; DROUGHT STRESS; DROSOPHILA-MELANOGASTER; PLANT-RESPONSES; FLORAL TRAITS; HYDRAULIC ARCHITECTURE; PHYSIOLOGICAL TRAITS AB Drought limits light harvesting, resulting in lower plant growth and reproduction. One trait important for plant drought response is water-use efficiency (WUE). We investigated (1) how the joint genetic architecture of WUE, reproductive characters, and vegetative traits changed across drought and well-watered conditions, (2) whether traits with distinct developmental bases (e.g. leaf gas exchange versus reproduction) differed in the environmental sensitivity of their genetic architecture, and (3) whether quantitative variation in circadian period was related to drought response in Brassica rapa. Overall, WUE increased in drought, primarily because stomatal conductance, and thus water loss, declined more than carbon fixation. Genotypes with the highest WUE in drought expressed the lowest WUE in well-watered conditions, and had the largest vegetative and floral organs in both treatments. Thus, large changes in WUE enabled some genotypes to approach vegetative and reproductive trait optima across environments. The genetic architecture differed for gas-exchange and vegetative traits across drought and well-watered conditions, but not for floral traits. Correlations between circadian and leaf gas-exchange traits were significant but did not vary across treatments, indicating that circadian period affects physiological function regardless of water availability. These results suggest that WUE is important for drought tolerance in Brassica rapa and that artificial selection for increased WUE in drought will not result in maladaptive expression of other traits that are correlated with WUE. C1 [Edwards, Christine E.; Ewers, Brent E.; Weinig, Cynthia] Univ Wyoming, Dept Bot, Laramie, WY 82071 USA. [Ewers, Brent E.; Weinig, Cynthia] Univ Wyoming, Program Ecol, Laramie, WY 82071 USA. [McClung, C. Robertson; Lou, Ping] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA. RP Edwards, CE (reprint author), USACE ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Christine.e.edwards@usace.army.mil RI Lou, Ping/C-2127-2009; OI Lou, Ping/0000-0003-1084-0671; McClung, C. Robertson/0000-0002-7875-3614; Edwards, Christine/0000-0001-8837-4872 FU NSF [DBI 0605736] FX This research was supported by NSF grant #DBI 0605736. NR 98 TC 24 Z9 24 U1 3 U2 41 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1674-2052 J9 MOL PLANT JI Mol. Plant. PD MAY PY 2012 VL 5 IS 3 BP 653 EP 668 DI 10.1093/mp/sss004 PG 16 WC Biochemistry & Molecular Biology; Plant Sciences SC Biochemistry & Molecular Biology; Plant Sciences GA 953RM UT WOS:000304890600014 PM 22319207 ER PT J AU Paredes, AH Torres, DM Harrison, SA AF Paredes, Angelo H. Torres, Dawn M. Harrison, Stephen A. TI Nonalcoholic Fatty Liver Disease SO CLINICS IN LIVER DISEASE LA English DT Article DE Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Diagnosis; Treatment ID RANDOMIZED CONTROLLED-TRIAL; MAGNETIC-RESONANCE ELASTOGRAPHY; PLACEBO-CONTROLLED TRIAL; OBSTRUCTIVE SLEEP-APNEA; CHRONIC HEPATITIS-C; LIFE-STYLE MODIFICATION; METABOLIC SYNDROME; LONG-TERM; INSULIN-RESISTANCE; NATURAL-HISTORY AB As the hepatic manifestation of the metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common cause of asymptomatic liver enzyme elevations in Western nations. Although it is easy to diagnose NAFLD, a liver biopsy is currently required to diagnose nonalcoholic steatohepatitis (NASH). Patients with NASH are those at greatest risk of progression to cirrhosis and, thus, treatment efforts are targeted to these individuals. Although currently there are no FDA-approved treatments for NASH, a multidisciplinary approach that addresses comorbid conditions and promotes modest weight loss comprises the backbone of therapy. C1 [Harrison, Stephen A.] San Antonio Mil Med Ctr, Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Paredes, Angelo H.; Torres, Dawn M.] Walter Reed Natl Mil Med Ctr, Dept Med, Div Gastroenterol, Bethesda, MD 20889 USA. RP Harrison, SA (reprint author), San Antonio Mil Med Ctr, Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 161 TC 43 Z9 46 U1 1 U2 13 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1089-3261 J9 CLIN LIVER DIS JI Clin. Liver Dis. PD MAY PY 2012 VL 16 IS 2 BP 397 EP + DI 10.1016/j.cld.2012.03.005 PG 24 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 949JL UT WOS:000304572400014 PM 22541706 ER PT J AU Anderson, WS Azhar, F Kudela, P Bergey, GK Franaszczuk, PJ AF Anderson, William S. Azhar, Feraz Kudela, Pawel Bergey, Gregory K. Franaszczuk, Piotr J. TI Epileptic seizures from abnormal networks: Why some seizures defy predictability SO EPILEPSY RESEARCH LA English DT Article DE Computational simulation; Neural network model; Seizure prediction; Seizure generation ID HIGH-FREQUENCY OSCILLATIONS; UNSTABLE PERIODIC-ORBITS; DENTATE GYRUS; NEURONAL NETWORKS; TEMPORAL-LOBE; TIME-SERIES; MODEL; PREDICTION; NEOCORTEX; BRAIN AB Seizure prediction has proven to be difficult in clinically realistic environments. Is it possible that fluctuations in cortical firing could influence the onset of seizures in an ictal zone? To test this, we have now used neural network simulations in a computational model of cortex having a total of 65,536 neurons with intercellular wiring patterned after histological data. A spatially distributed Poisson driven background input representing the activity of neighboring cortex affected 1% of the neurons. Gamma distributions were fit to the interbursting phase intervals, a non-parametric test for randomness was applied, and a dynamical systems analysis was performed to search for period-1 orbits in the intervals. The non-parametric analysis suggests that intervals are being drawn at random from their underlying joint distribution and the dynamical systems analysis is consistent with a nondeterministic dynamical interpretation of the generation of bursting phases. These results imply that in a region of cortex with abnormal connectivity analogous to a seizure focus, it is possible to initiate seizure activity with fluctuations of input from the surrounding cortical regions. These findings suggest one possibility for ictal generation from abnormal focal epileptic networks. This mechanism additionally could help explain the difficulty in predicting partial seizures in some patients. (C) 2011 Elsevier B.V. All rights reserved. C1 [Anderson, William S.; Azhar, Feraz] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21287 USA. [Kudela, Pawel; Bergey, Gregory K.; Franaszczuk, Piotr J.] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21287 USA. [Franaszczuk, Piotr J.] USA, Res Lab, Human Res & Engn Directorate, Adelphi, MD 20783 USA. RP Anderson, WS (reprint author), Johns Hopkins Univ, Sch Med, Dept Neurosurg, Meyer 5-109E,600 N Wolfe St, Baltimore, MD 21287 USA. EM wanders5@jhmi.edu; fazhar1@jhmi.edu; pkudela@jhmi.edu; gbergey@jhmi.edu; pfranasz@gmail.com RI Franaszczuk, Piotr/B-6532-2008 OI Franaszczuk, Piotr/0000-0002-5166-4224 FU NIH-NINDS [K08 (K08NS066099-01A1)] FX WSA is supported by NIH-NINDS K08 (K08NS066099-01A1). NR 63 TC 12 Z9 14 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-1211 EI 1872-6844 J9 EPILEPSY RES JI Epilepsy Res. PD MAY PY 2012 VL 99 IS 3 BP 202 EP 213 DI 10.1016/j.eplepsyres.2011.11.006 PG 12 WC Clinical Neurology SC Neurosciences & Neurology GA 948NP UT WOS:000304510200002 PM 22169211 ER PT J AU Pulskamp, JS Bedair, SS Polcawich, RG Smith, GL Martin, J Power, B Bhave, SA AF Pulskamp, Jeffrey S. Bedair, Sarah S. Polcawich, Ronald G. Smith, Gabriel L. Martin, Joel Power, Brian Bhave, Sunil A. TI Electrode-Shaping for the Excitation and Detection of Permitted Arbitrary Modes in Arbitrary Geometries in Piezoelectric Resonators SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID TOPOLOGY OPTIMIZATION; SMART STRUCTURES; MODAL ACTUATORS; MEMS; FILTERS; SENSORS; DESIGN; ALN AB This paper reports theoretical analysis and experimental results on a numerical electrode shaping design technique that permits the excitation of arbitrary modes in arbitrary geometries for piezoelectric resonators, for those modes permitted to exist by the nonzero piezoelectric coefficients and electrode configuration. The technique directly determines optimal electrode shapes by assessing the local suitability of excitation and detection electrode placement on two-port resonators without the need for iterative numerical techniques. The technique is demonstrated in 61 different electrode designs in lead zirconate titanate (PZT) thin film on silicon RF micro electro-mechanical system (MEMS) plate, beam, ring, and disc resonators for out-of-plane flexural and various contour modes up to 200 MHz. The average squared effective electromechanical coupling factor for the designs was 0.54%, approximately equivalent to the theoretical maximum value of 0.53% for a fully electroded length-extensional mode beam resonator comprised of the same composite. The average improvement in S21 for the electrode-shaped designs was 14.6 dB with a maximum improvement of 44.3 dB. Through this piezoelectric electrodeshaping technique, 95% of the designs showed a reduction in insertion loss. C1 [Pulskamp, Jeffrey S.; Bedair, Sarah S.; Polcawich, Ronald G.; Smith, Gabriel L.; Martin, Joel; Power, Brian] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Bhave, Sunil A.] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY USA. RP Pulskamp, JS (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. EM jeffrey.s.pulskamp.civ@mail.mil RI Bedair, Sarah/D-9130-2013 NR 53 TC 17 Z9 17 U1 2 U2 18 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAY PY 2012 VL 59 IS 5 BP 1043 EP 1060 DI 10.1109/TUFFC.2012.2290 PG 18 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 949AL UT WOS:000304547000022 PM 22622990 ER PT J AU Sahar, DE Walker, JA Wang, HT Stephenson, SM Shah, AR Krishnegowda, NK Wenke, JC AF Sahar, David E. Walker, John A. Wang, Howard T. Stephenson, Stacy M. Shah, Amita R. Krishnegowda, Naveen K. Wenke, Joseph C. TI Effect of Endothelial Differentiated Adipose-Derived Stem Cells on Vascularity and Osteogenesis in Poly(D,L-Lactide) Scaffolds In Vivo SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Endothelial cells; adult stem cells; angiogenesis; osteogenesis; tissue engineering ID CALVARIAL DEFECTS; TISSUE; BONE; VITRO AB Prevascularization of engineered bony constructs can potentially improve in vivo viability. However, the effect of endothelial cells on osteogenesis is unknown when placed in poly(D,L-lactide) (PLA) scaffolds alone. Adipose-derived stem cells (ASCs) have the ability to differentiate into both osteoblasts and endothelial cells by culture in specific media. We hypothesized that ASC-derived endothelial cells would improve vascularity with minimal contribution to bone formation when placed in scaffold alone. ASCs were successfully differentiated into endothelial cells (ASC-Endo) and osteoblasts (ASC-Osteo) using media supplemented with vascular endothelial growth factor and bone morphogenic protein 2, respectively. Tissue-engineered constructs were created with PLA matrices containing no cells (control), undifferentiated ASCs (ASCs), osteogenic-differentiated ASCs (ASC-Osteo), or endothelial differentiated ASCs (ASC-Endo), and these constructs were evaluated in critical-size Lewis rat calvarial defect model (n = 34). Eight weeks after implantation, the bone volume and microvessel population of bony constructs were evaluated by micro-computed tomography analysis and histologic staining. Bone volumes for ASCs and ASC-Osteo constructs, 0.7 and 0.91 mm(3), respectively, were statistically greater than that for ASC-Endo, 0.28 mm(3) (P < 0.05). There was no statistical difference between the PLA control (0.5 mm(3)) and ASC-Endo (0.28 mm(3)) constructs in bone formation. The percent area of microvessels within constructs was highest in the ASC-Endo group, although it did not reach statistical significance (0.065). Prevascularization of PLA scaffold with ASC-Endo cells will not increase bone formation by itself but may be used as a cell source for improving vascularization and potentially improving existing osteoblast function. C1 [Sahar, David E.] UC Davis Sch Med, Div Plast Surg, Sacramento, CA 95817 USA. [Walker, John A.; Wang, Howard T.; Stephenson, Stacy M.; Shah, Amita R.; Krishnegowda, Naveen K.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Wenke, Joseph C.] USA, Inst Surg Res, San Antonio, TX USA. RP Sahar, DE (reprint author), UC Davis Sch Med, Div Plast Surg, 2221 Stockton Blvd,Room 2125, Sacramento, CA 95817 USA. EM david.sahar@ucdmc.ucdavis.edu FU Plastic Surgery Education Foundation; US Army Institute of Surgical Research FX This work was supported by the Plastic Surgery Education Foundation and US Army Institute of Surgical Research. NR 21 TC 9 Z9 11 U1 1 U2 10 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD MAY PY 2012 VL 23 IS 3 BP 913 EP 918 DI 10.1097/SCS.0b013e31824e5cd8 PG 6 WC Surgery SC Surgery GA 948BW UT WOS:000304479600111 PM 22627404 ER PT J AU Ioannou, A Lapchak, P Kannan, L Rani, P Lucca, JD Lambris, J George, T AF Ioannou, Antonis Lapchak, Peter Kannan, Lakshmi Rani, Poonam Lucca, Jurandir Dalle Lambris, John George, Tsokos TI Complement Orchestrates T cell response during Mesenteric Ischemia Reperfusion Injury in Autoimmune Prone Mice SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Ioannou, Antonis; Lapchak, Peter; Kannan, Lakshmi; Rani, Poonam; George, Tsokos] Beth Israel Deaconess Med Ctr, Med Div Rheumatol, Boston, MA 02215 USA. [Lucca, Jurandir Dalle] USA, Inst Surg Res, San Antonio, TX USA. [Lambris, John] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659702066 ER PT J AU Ioannou, A Lapchak, P Rani, P Lieberman, L Yoshiya, K Kannan, L Lucca, JD Kowalska, A Tsokos, G AF Ioannou, Antonis Lapchak, Peter Rani, Poonam Lieberman, Linda Yoshiya, Kazuhisa Kannan, Lakshmi Lucca, Jurandir Dalle Kowalska, Anna Tsokos, George TI The role of Platelet Factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Ioannou, Antonis; Lapchak, Peter; Rani, Poonam; Lieberman, Linda; Yoshiya, Kazuhisa; Kannan, Lakshmi; Tsokos, George] Beth Israel Deaconess Med Ctr, Med Div Rheumatol, Boston, MA 02215 USA. [Kowalska, Anna] Univ Penn, Sch Med, Dept Pediat, Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Lucca, Jurandir Dalle] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659701219 ER PT J AU Kannan, L Lapchak, P Ioannou, A Rani, P Lucca, JD Tsokos, G AF Kannan, Lakshmi Lapchak, Peter Ioannou, Antonis Rani, Poonam Lucca, Jurandir Dalle Tsokos, George TI Platelet-associated CD40/CD154 mediates remote tissue damage after mesenteric ischemia/reperfusion injury SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Kannan, Lakshmi; Lapchak, Peter; Ioannou, Antonis; Rani, Poonam; Tsokos, George] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Lucca, Jurandir Dalle] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659700331 ER PT J AU Moon, J Suh, H Li, A Yadava, A Irvine, D AF Moon, James Suh, Heikyung Li, Adrienne Yadava, Anjali Irvine, Darrell TI Nanoparticle vaccines enhance humoral responses to a malaria antigen by expanding Tfh cells and inducing germinal center formation SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Moon, James; Suh, Heikyung; Li, Adrienne; Irvine, Darrell] MIT, Cambridge, MA 02139 USA. [Yadava, Anjali] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Suh, Heikyung; Irvine, Darrell] Howard Hughes Med Inst, Chevy Chase, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659701642 ER PT J AU Pichugin, A Ehrler, L Sehrawat, S Funk, T Speake, C Duffy, P Ploegh, H Krzych, U AF Pichugin, Alexander Ehrler, Lindsey Sehrawat, Sharvan Funk, Theresa Speake, Cate Duffy, Patrick Ploegh, Hidde Krzych, Urszula TI Identification of Plasmodium berghei novel liver stage CD8 T cell epitopes by caged MHC class I tetramer technology SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Pichugin, Alexander; Ehrler, Lindsey; Funk, Theresa; Krzych, Urszula] Walter Reed Army Inst Res, MMRP, Malaria Vaccine Branch, Silver Spring, MD USA. [Sehrawat, Sharvan; Ploegh, Hidde] Whitehead Inst Biomed Res, Ploegh Lab, Cambridge, MA 02142 USA. [Speake, Cate; Duffy, Patrick] Seattle BioMed, Malaria, Seattle, WA USA. [Duffy, Patrick] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659700092 ER PT J AU Sholukh, A Mukhtar, M Humbert, M Essono, S Watkins, J Shanmuganathan, V Hemashettar, G Hu, SL Montefiori, D Polonis, V Schur, P Ruprecht, R AF Sholukh, Anton Mukhtar, Muhammad Humbert, Michael Essono, Sosthene Watkins, Jennifer Shanmuganathan, Vivekanandan Hemashettar, Girish Hu, Shiu-Lok Montefiori, David Polonis, Victoria Schur, Peter Ruprecht, Ruth TI Isolation of neutralizing monoclonal antibodies against HIV-1 with predetermined conformational epitope specificity SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Sholukh, Anton; Mukhtar, Muhammad; Humbert, Michael; Essono, Sosthene; Watkins, Jennifer; Shanmuganathan, Vivekanandan; Hemashettar, Girish; Ruprecht, Ruth] Dana Farber Canc Inst, Boston, MA 02115 USA. [Sholukh, Anton; Mukhtar, Muhammad; Humbert, Michael; Essono, Sosthene; Watkins, Jennifer; Ruprecht, Ruth] Harvard Univ, Sch Med, Boston, MA USA. [Hu, Shiu-Lok] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA. [Montefiori, David] Duke Univ, Sch Med, Dept Surg, Durham, NC USA. [Polonis, Victoria] Walter Reed Army Inst Res, Mil HIV Res Program, Rockville, MD USA. [Schur, Peter] Brigham & Womens Hosp, Dept Rheumatol Immunol & Allergy, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659700597 ER PT J AU Zak, S Kuehne, A Barth, J Herbert, A Muhammad, M Ortiz, R Prugar, L Hannah, B Bakken, R Pratt, W Dye, J AF Zak, Samantha Kuehne, Ana Barth, James Herbert, Andrew Muhammad, Majidat Ortiz, Ramon Prugar, Laura Hannah, Brian Bakken, Russell Pratt, William Dye, John TI Anti-vector immunity following vaccination with Venezuelan equine encephalitis replicon filovirus vaccine SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Zak, Samantha; Kuehne, Ana; Barth, James; Herbert, Andrew; Muhammad, Majidat; Ortiz, Ramon; Prugar, Laura; Hannah, Brian; Bakken, Russell; Pratt, William; Dye, John] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659701088 ER PT J AU Zarling, S Spring, M Ehrler, L Chalom, I Funk, T Cowman, A Ockenhouse, C Speake, C Heppner, D Duffy, P Kappe, S Krzych, U AF Zarling, Stasya Spring, Michele Ehrler, Lindsey Chalom, Isaac Funk, Theresa Cowman, Alan Ockenhouse, Christian Speake, Cate Heppner, D. Duffy, Patrick Kappe, Stefan Krzych, Urszula TI Ag-specific recall of cytokine producing CD4 and CD8 T cells in humans immunized with genetically attenuated Plasmodium falciparum sporozoite SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the American-Association-of-Immunologists CY MAY 04-08, 2012 CL Boston, MA SP Amer Assoc Immunol C1 [Zarling, Stasya; Spring, Michele; Ehrler, Lindsey; Chalom, Isaac; Funk, Theresa; Ockenhouse, Christian; Heppner, D.; Krzych, Urszula] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA. [Zarling, Stasya] CNR, Res Associateship Program, Washington, DC 20418 USA. [Cowman, Alan] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia. [Speake, Cate; Duffy, Patrick; Kappe, Stefan] Seattle Biomed, Malaria, Seattle, WA USA. [Duffy, Patrick] NIAID, Lab Malaria Immunol & Vaccinol, NIH, Rockville, MD USA. RI Cowman, Alan/C-7642-2013 OI Cowman, Alan/0000-0001-5145-9004 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 2012 VL 188 PG 1 WC Immunology SC Immunology GA 950OX UT WOS:000304659701640 ER PT J AU Cho, RI Elner, VM Nelson, CC AF Cho, Raymond I. Elner, Victor M. Nelson, Christine C. TI Reply re: "The Effect of Orbital Decompression Surgery on Lid Retraction in Thyroid Eye Disease" SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Letter ID OPHTHALMOPATHY C1 [Cho, Raymond I.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Cho, RI (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM raymond.cho@amedd.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0740-9303 J9 OPHTHAL PLAST RECONS JI Ophthalmic Plast. Reconstr. Surg. PD MAY-JUN PY 2012 VL 28 IS 3 BP 229 EP 230 DI 10.1097/IOP.0b013e3182523b97 PG 2 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 948VK UT WOS:000304530700030 ER PT J AU Fu, R AF Fu, Richard TI Structure and Process of Infrared Hot Electron Transistor Arrays SO SENSORS LA English DT Article DE quantum well infrared photodetector (QWIP); infrared hot-electron transistor (IHET); GaAs ID OPERATION AB An infrared hot-electron transistor (IHET) 5 x 8 array with a common base configuration that allows two-terminal readout integration was investigated and fabricated for the first time. The IHET structure provides a maximum factor of six in improvement in the photocurrent to dark current ratio compared to the basic quantum well infrared photodetector (QWIP), and hence it improved the array S/N ratio by the same factor. The study also showed for the first time that there is no electrical cross-talk among individual detectors, even though they share the same emitter and base contacts. Thus, the IHET structure is compatible with existing electronic readout circuits for photoconductors in producing sensitive focal plane arrays. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Fu, R (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM richard.x.fu.civ@mail.mil FU U.S. Army Research Laboratory FX This work was supported by the U.S. Army Research Laboratory. NR 8 TC 0 Z9 0 U1 1 U2 3 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD MAY PY 2012 VL 12 IS 5 BP 6508 EP 6519 DI 10.3390/s120506508 PG 12 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 948YE UT WOS:000304539200076 PM 22778655 ER PT J AU Brickey, J Walczak, S Burgess, T AF Brickey, Jonalan Walczak, Steven Burgess, Tony TI Comparing Semi-Automated Clustering Methods for Persona Development SO IEEE TRANSACTIONS ON SOFTWARE ENGINEERING LA English DT Article DE Clustering; interaction styles; personas; user-centered design; user interfaces ID INFORMATION-TECHNOLOGY; AGREEMENT AB Current and future information systems require a better understanding of the interactions between users and systems in order to improve system use and, ultimately, success. The use of personas as design tools is becoming more widespread as researchers and practitioners discover its benefits. This paper presents an empirical study comparing the performance of existing qualitative and quantitative clustering techniques for the task of identifying personas and grouping system users into those personas. A method based on Factor (Principal Components) Analysis performs better than two other methods which use Latent Semantic Analysis and Cluster Analysis as measured by similarity to expert manually defined clusters. C1 [Brickey, Jonalan] US Army, Combating Terrorism Ctr, West Point, NY 10996 USA. [Walczak, Steven] Univ Colorado Denver, Sch Business, Denver, CO 80217 USA. [Burgess, Tony] US Mil Acad, US Armys, Ctr Adv Leader Dev & Org Learning CALDOL, West Point, NY 10996 USA. RP Brickey, J (reprint author), US Army, Combating Terrorism Ctr, 122 Lincoln Hall USMA, West Point, NY 10996 USA. EM Jonalan.Brickey@us.army.mil; Steven.Walczak@ucdenver.edu; Tony.Burgess@usma.edu OI Walczak, Steven/0000-0002-0449-6272 FU US Army's Center for the Advancement of Leader Development and Organizational Learning at the US Military Academy FX The authors wish to thank the members of the US Army's Company Command forum and the members of the expert panel. This work was supported in part by a grant from the US Army's Center for the Advancement of Leader Development and Organizational Learning at the US Military Academy. The authors also wish to thank Thomas Miaskiewicz for his assistance in understanding and developing our LSA model. NR 45 TC 5 Z9 5 U1 0 U2 5 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0098-5589 J9 IEEE T SOFTWARE ENG JI IEEE Trans. Softw. Eng. PD MAY-JUN PY 2012 VL 38 IS 3 BP 537 EP 546 DI 10.1109/TSE.2011.60 PG 10 WC Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 947FP UT WOS:000304414400003 ER PT J AU Carr-Betts, E Beck, TM Kraus, NC AF Carr-Betts, Erica Beck, Tanya M. Kraus, Nicholas C. TI Tidal Inlet Morphology Classification and Empirical Determination of Seaward and Down-Drift Extents of Tidal Inlets SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Tidal inlet; tidal prism; tidal inlet morphology; tide dominated; wave dominated; mixed energy inlets AB CARR-BETTS, E.; BECK, T.M., and KRAUS, N.C., 2012. Tidal inlet morphology classification and empirical determination of seaward and down-drift extents of tidal inlets. Journal of Coastal Research, 28(3), 547-556. West Palm Beach (Florida), ISSN 0749-0208. The Hayes classification of tidal inlet geomorphic type and the distances from the inlet to the most seaward and down-drift extents of ebb deltas are examined. For this purpose, a database was compiled for 89 tidal inlets along the Atlantic Ocean, Gulf of Mexico, and Pacific Ocean coasts of the United States. The database contains spring or diurnal tidal prism and the average significant wave height and wave period from a 20-year hindcast. The Hayes diagram aims to classify inlet plan-view morphology by tide range and wave height. Based on the work presented here, it is concluded that the inlet classification of Hayes has limited applicability for describing the morphology of typical tidal inlets, and replacement of tide range by inlet tidal prism did not improve the classification. Best correlation for the two ebb delta extents was found for inlets segregated by wave exposure (as mild, moderate, or high) and by tidal prism. There was poor or no correlation for moderately wave-exposed inlets, and moderate to high correlation was found for mildly and highly exposed inlets. The seaward and down-drift extents of inlets tend to remain constant up to a tidal prism less than 10(8) m(3), depending on wave exposure, and then increase linearly with tidal prism. It is postulated that a tidal prism less than approximately 10(8) m(3) is a tipping point required to overcome other factors controlling tidal inlet plan-form morphology. C1 [Beck, Tanya M.; Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Carr-Betts, E (reprint author), 7643 NW 70th Ave, Parkland, FL 33067 USA. EM bettscarr@bellsouth.net NR 23 TC 2 Z9 2 U1 1 U2 7 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD MAY PY 2012 VL 28 IS 3 BP 547 EP 556 DI 10.2112/JCOASTRES-D-11-00124.1 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 945NM UT WOS:000304283200003 ER PT J AU Xue, RD Qualls, WA Smith, ML Gaines, MK Weaver, JH Debboun, M AF Xue, Rui-De Qualls, Whitney A. Smith, Michael L. Gaines, Marcia K. Weaver, James H. Debboun, Mustapha TI Field Evaluation of the Off! Clip-On Mosquito Repellent (Metofluthrin) Against Aedes albopictus and Aedes taeniorhynchus (Diptera: Culicidae) in Northeastern Florida SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Aedes albopictus; Aedes taenirohynchus; mosquito repellent; metofluthrin; personal protection ID IMPREGNATED PLASTIC STRIPS; SPATIAL REPELLENCY; PAPER STRIP; INDONESIA; LOMBOK; N,N-DIETHYL-M-TOLUAMIDE; ANOPHELES; SHELTERS; EXPOSURE; VIETNAM AB Repellent efficacy of the Off! Clip-on Mosquito Repellent device (S. C. Johnson and Son, Inc., Racine, WI) containing Metofluthrin was evaluated on six human volunteers against the container-breeding mosquito Aedes albopictus (Skuse) and the salt marsh mosquito Aedes taeniorhynchus (Wiedemann) at two field locations in northeastern Florida. The device repelled mosquitoes by releasing a vaporized form of the pyrethroid insecticide metofluthrin ([AI] 31.2%) and provided 70% protection from Ae. albopictus bites for >3 h. For the second field trial, a repellent device that was used in the first trial was tested after being open for > 1 wk. This device provided 79% protection from Ae. taeniorhynchus bites for 3 h. Our field results showed that the repellent device was 70 and 79% effective at repelling Ae. albopictus and Ae. taeniorhynchus from human test subjects in both field locations in northeastern Florida. C1 [Xue, Rui-De; Qualls, Whitney A.; Smith, Michael L.; Gaines, Marcia K.; Weaver, James H.] Anastasia Mosquito Control Dist, St Augustine, FL 32080 USA. [Debboun, Mustapha] USA, Med Dept Ctr & Sch, Acad Hlth Sci, Dept Prevent Hlth Serv, Ft Sam Houston, TX 78234 USA. RP Xue, RD (reprint author), Anastasia Mosquito Control Dist, 500 Old Beach Rd, St Augustine, FL 32080 USA. EM xueamcd@gmail.com NR 20 TC 12 Z9 12 U1 1 U2 7 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 2012 VL 49 IS 3 BP 652 EP 655 DI 10.1603/ME10227 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 941TU UT WOS:000303989900027 PM 22679874 ER PT J AU Kok, BC Herrell, RK Thomas, JL Hoge, CW AF Kok, Brian C. Herrell, Richard K. Thomas, Jeffrey L. Hoge, Charles W. TI Posttraumatic Stress Disorder Associated With Combat Service in Iraq or Afghanistan Reconciling Prevalence Differences Between Studies SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article DE Posttraumatic stress disorder; PTSD; prevalence; meta-analysis; military; Iraq; Afghanistan ID MENTAL-HEALTH PROBLEMS; TRAUMATIC BRAIN-INJURY; US SOLDIERS; MILLENNIUM COHORT; MILITARY SERVICE; PTSD CHECKLIST; UK MILITARY; DEPLOYMENT; WAR; SYMPTOMS AB Studies of posttraumatic stress disorder (PTSD) prevalence associated with deployment to Iraq or Afghanistan report wide variability, making interpretation and projection for research and public health purposes difficult. This article placed this literature within a military context. Studies were categorized according to deployment time-frame, screening case definition, and study group (operational infantry units exposed to direct combat versus population samples with a high proportion of support personnel). Precision weighted averages were calculated using a fixed-effects meta-analysis. Using a specific case definition, the weighted postdeployment PTSD prevalence was 5.5% (95% CI, 5.4-5.6) in population samples and 13.2% (12.8-13.7) in operational infantry units. Both population-level and unit-specific studies provided valuable and unique information for public health purposes; understanding the military context is essential for interpreting prevalence studies. C1 [Kok, Brian C.; Herrell, Richard K.; Thomas, Jeffrey L.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Kok, BC (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM brian.kok@us.army.mil NR 56 TC 61 Z9 61 U1 0 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD MAY PY 2012 VL 200 IS 5 BP 444 EP 450 DI 10.1097/NMD.0b013e3182532312 PG 7 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 946ET UT WOS:000304335000012 PM 22551799 ER PT J AU Chung, KK AF Chung, Kevin K. TI EDITORIAL CRITIQUE SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Editorial Material ID CONTINUOUS VENOVENOUS HEMOFILTRATION; RANDOMIZED CONTROLLED-TRIAL; HIGH-VOLUME HEMOFILTRATION; SEPTIC SHOCK; FAILURE; INJURY; SEPSIS C1 USA, Inst Surg Res, San Antonio, TX USA. RP Chung, KK (reprint author), USA, Inst Surg Res, San Antonio, TX USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAY PY 2012 VL 72 IS 5 BP 1237 EP 1238 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 944JD UT WOS:000304195100025 ER PT J AU Papa, L Lewis, LM Silvestri, S Falk, JL Giordano, P Brophy, GM Demery, JA Liu, MC Mo, JX Akinyi, L Mondello, S Schmid, K Robertson, CS Tortella, FC Hayes, RL Wang, KKW AF Papa, Linda Lewis, Lawrence M. Silvestri, Salvatore Falk, Jay L. Giordano, Philip Brophy, Gretchen M. Demery, Jason A. Liu, Ming Cheng Mo, Jixiang Akinyi, Linnet Mondello, Stefania Schmid, Kara Robertson, Claudia S. Tortella, Frank C. Hayes, Ronald L. Wang, Kevin K. W. TI Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Traumatic brain injury; biomarkers; serum; intracranial lesions; neurosurgical intervention ID MINOR HEAD-INJURY; COMPUTED-TOMOGRAPHY; RADIATION-EXPOSURE; BIOMARKER; PROTEIN; S100B; RULE; RATS; COMA; US AB BACKGROUND: This study compared early serum levels of ubiquitin C-terminal hydrolase (UCH-L1) from patients with mild and moderate traumatic brain injury (TBI) with uninjured and injured controls and examined their association with traumatic intracranial lesions on computed tomography (CT) scan (CT positive) and the need for neurosurgical intervention (NSI). METHODS: This prospective cohort study enrolled adult patients presenting to three tertiary care Level I trauma centers after blunt head trauma with loss of consciousness, amnesia, or disorientation and a Glasgow Coma Scale (GCS) score 9 to 15. Control groups included normal uninjured controls and nonhead injured trauma controls presenting to the emergency department with orthopedic injuries or motor vehicle crash without TBI. Blood samples were obtained in all trauma patients within 4 hours of injury and measured by enzyme-linked immunosorbent assay for UCH-L1 (ng/mL +/- standard error of the mean). RESULTS: There were 295 patients enrolled, 96 TBI patients (86 with GCS score 13-15 and 10 with GCS score 9-12), and 199 controls (176 uninjured, 16 motor vehicle crash controls, and 7 orthopedic controls). The AUC for distinguishing TBI from uninjured controls was 0.87 (95% confidence interval [CI], 0.82-0.92) and for distinguishing those TBIs with GCS score 15 from controls was AUC 0.87 (95% CI, 0.81-0.93). Mean UCH-L1 levels in patients with CT negative versus CT positive were 0.620 (+/- 0.254) and 1.618 (+/- 0.474), respectively (p < 0.001), and the AUC was 0.73 (95% CI, 0.62-0.84). For patients without and with NSI, levels were 0.627 (0.218) versus 2.568 (0.854; p < 0.001), and the AUC was 0.85 (95% CI, 0.76-0.94). CONCLUSION: UCH-L1 is detectable in serum within an hour of injury and is associated with measures of injury severity including the GCS score, CT lesions, and NSI. Further study is required to validate these findings before clinical application. (J Trauma. 2012;72: 1335-1344. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Papa, Linda; Silvestri, Salvatore; Falk, Jay L.; Giordano, Philip] Orlando Reg Med Ctr Inc, Dept Emergency Med, Orlando, FL 32806 USA. [Lewis, Lawrence M.] Washington Univ, Sch Med, Div Emergency Med, St Louis, MO USA. [Liu, Ming Cheng; Mo, Jixiang; Akinyi, Linnet; Mondello, Stefania; Hayes, Ronald L.] Banyan Biomarkers Inc, Alachua, FL USA. [Brophy, Gretchen M.] Virginia Commonwealth Univ, Richmond, VA USA. [Demery, Jason A.] Univ Florida, Forens Inst, UF Springhill Hlth Ctr, Gainesville, FL USA. [Schmid, Kara; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD USA. [Robertson, Claudia S.] Baylor Coll Med, Dept Crit Care & Neurosurg, Houston, TX 77030 USA. [Wang, Kevin K. W.] Univ Florida, Dept Psychiat, Gainesville, FL 32611 USA. RP Papa, L (reprint author), Orlando Reg Med Ctr Inc, Dept Emergency Med, 86 W Underwood,S-200, Orlando, FL 32806 USA. EM lpstat@aol.com RI Mondello, Stefania/A-1813-2012; OI Mondello, Stefania/0000-0002-8587-3614; Wang, Kevin/0000-0002-9343-6473 FU NINDS NIH HHS [R01 NS057676, R01NS057676] NR 41 TC 64 Z9 67 U1 2 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAY PY 2012 VL 72 IS 5 BP 1335 EP 1344 DI 10.1097/TA.0b013e3182491e3d PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 944JD UT WOS:000304195100042 PM 22673263 ER PT J AU Radowsky, JS Baines, L Howard, RS Shriver, CD Buckenmaier, CC Stojadinovic, A AF Radowsky, Jason S. Baines, Lyndsay Howard, Robin S. Shriver, Craig D. Buckenmaier, Chester C., III Stojadinovic, Alexander TI Pain Ratings by Patients and Their Providers of Radionucleotide Injection for Breast Cancer Lymphatic Mapping SO PAIN MEDICINE LA English DT Article DE Pain; Sentinel Lymph Node; Lymphatic Mapping; Outcomes; Breast Cancer; Radioisotope ID ETHNICITY; ANALGESIA; SEVERITY AB Background. Disparity between patient report and physician perception of pain from radiotracer injection for sentinel node biopsy is thought to center on the severity of the intervention, ethnic composition of population queried, and socioeconomic factors. Objective. The objectives of this study were, first, to explore agreement between physicians' and their breast cancer patients' pain assessment during subareolar radionucleotide injection; and second, to evaluate potential ethnic differences in ratings. Methods. A trial was conducted, from January 2006 to April 2009, where 140 breast cancer patients were randomly assigned to standard topical lidocaine-4% cream and 99mTc-sulfur colloid injection, or to one of three other groups: placebo cream and 99mTc-sulfur colloid injection containing NaHCO3, 1% lidocaine, or NaHCO3 + 1% lidocaine. Providers and patients completed numeric pain scales (010) immediately after injection. Results. Patients and providers rated pain similarly over the entire cohort (median, 3 vs 2, P = 0.15). Patients rated pain statistically significantly higher than physicians in the standard (6 vs 5, P = 0.045) and placebo + NaHCO3 (5 vs 4, P = 0.032) groups. No significant difference in scores existed between all African Americans and their physicians (3 vs 4, P = 0.27). Conclusion. Patientphysician pain assessment congruence over the less painful injections and their statistically similar scores with the more painful methods suggests the importance of utilizing the least painful method possible. Providers tended to underestimate patients with the highest pain ratingsthose in the greatest analgesic need. Lack of statistical difference between African American and physician scores may reflect the equal-access-to-care over the entire patient cohort, supporting the conclusion that socioeconomic factors may lie at the heart of previously reported discrepancies. C1 [Radowsky, Jason S.; Baines, Lyndsay; Shriver, Craig D.; Buckenmaier, Chester C., III; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. [Shriver, Craig D.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Def & Vet Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. [Baines, Lyndsay] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Shriver, Craig D.; Stojadinovic, Alexander] US Mil Canc Inst, Clin Trials Grp, Washington, DC USA. RP Stojadinovic, A (reprint author), Walter Reed Natl Mil Med Ctr, Bldg 9,8901 Rockville Pike, Bethesda, MD 20889 USA. EM alexander.stojadinovic@us.army.mil FU John P. Murtha Neuroscience and Pain Institute; Clinical Breast Care Project; United States Military Cancer Institute FX This clinical research effort was supported by the John P. Murtha Neuroscience and Pain Institute, the Clinical Breast Care Project, and the United States Military Cancer Institute. NR 18 TC 9 Z9 9 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD MAY PY 2012 VL 13 IS 5 BP 670 EP 676 DI 10.1111/j.1526-4637.2012.01374.x PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 943PS UT WOS:000304137400010 PM 22536858 ER PT J AU Hu, GL Chen, CQ Ramesh, KT McCauley, JW AF Hu, Guangli Chen, C. Q. Ramesh, K. T. McCauley, J. W. TI Mechanisms of dynamic deformation and dynamic failure in aluminum nitride SO ACTA MATERIALIA LA English DT Article DE Sintering; Fracture; Deformation; Micromechanical modeling; Dislocations ID ALN PLASTIC-DEFORMATION; INDENTATION HARDNESS; CRACK-PROPAGATION; ROOM-TEMPERATURE; STACKING FAULTS; HIGH-PRESSURE; FRACTURE; STRESS; DISLOCATIONS; BEHAVIOR AB Uniaxial quasi-static, uniaxial dynamic and confined dynamic compression experiments have been performed to characterize the failure and deformation mechanisms of a sintered polycrystalline aluminum nitride using a servohydraulic machine and a modified Kolsky bar. Scanning electron microscopy and transmission electron microscopy (TEM) are used to identify the fracture and deformation mechanisms under high rate and high pressure loading conditions. These results show that the fracture mechanisms are strong functions of confining stress and strain rate, with transgranular fracture becoming more common at high strain rates. Dynamic fracture mechanics and micromechanical models are used to analyze the observed fracture mechanisms. TEM characterization of fragments from the confined dynamic experiments shows that at higher pressures dislocation motion becomes a common dominant deformation mechanism in AIN. Prismatic slip is dominant, and pronounced microcrack-dislocation interactions are observed, suggesting that the dislocation plasticity affects the macroscopic fracture behavior in this material under high confining stresses. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Hu, Guangli; Chen, C. Q.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [McCauley, J. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21078 USA. RP Ramesh, KT (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM ramesh@jhu.edu RI Hu, Guangli/F-2461-2011; Chen, Changqiang/G-6310-2010 OI Hu, Guangli/0000-0003-4751-1628; FU Center for Advanced Metallic and Ceramic Systems at the Johns Hopkins University; Army Research Laboratory under the REDCOM-ACQ-CTR [W911NF-06-2-0006] FX This work was performed under the auspices of the Center for Advanced Metallic and Ceramic Systems at the Johns Hopkins University, supported by Army Research Laboratory under the REDCOM-ACQ-CTR Cooperative Agreement No. W911NF-06-2-0006. Helpful discussions with Dr. Cao, Dr. Daphalapurkar and Dr. Kimberley are greatly appreciated. NR 49 TC 16 Z9 17 U1 3 U2 38 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD MAY PY 2012 VL 60 IS 8 BP 3480 EP 3490 DI 10.1016/j.actamat.2012.03.011 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 942CR UT WOS:000304020300023 ER PT J AU Belinskaya, T Pattabiraman, N DiTargiani, R Choi, M Saxena, A AF Belinskaya, Tatyana Pattabiraman, Nagarajan diTargiani, Robert Choi, Moonsuk Saxena, Ashima TI Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS LA English DT Article DE Mouse SMP-30; Squid DFPase; Human PON1; DFP; Catalytic bioscavenger; Molecular docking ID LOLIGO-VULGARIS; DIISOPROPYL PHOSPHOROFLUORIDATE; CRYSTAL-STRUCTURE; LACTONASE ACTIVITY; ENZYME; MICE; FLUOROPHOSPHATASE; PROPHYLAXIS; PHOSPHOTRIESTERASE; GLUCONOLACTONASE AB Senescence marker protein-30 (SMP-30) is a candidate enzyme that can function as a catalytic bioscavenger of organophosphorus (OP) nerve agents. We purified SMP-30 from mouse (Mo) liver and compared its hydrolytic activity towards various esters, lactones, and G-type nerve agents with that of human paraoxonase1 (Hu PON1) and squid diisopropylfluorophosphatase (DFPase). All three enzymes contain one or two metal ions in their active sites and fold into six-bladed beta-propeller structures. While Hu PON1 hydrolyzed a variety of lactones, the only lactone that was a substrate for Mo SMP-30 was D-(+)-gluconic acid delta-lactone. Squid DFPase was much more efficient at hydrolyzing DFP and G-type nerve agents as compared to Mo SMP-30 or Hu PON1. The K-m values for DFP were in the following order: Mo SMP-30 > Hu PON1 > squid DFPase, suggesting that the efficiency of DFP hydrolysis may be related to its binding in the active sites of these enzymes. Thus, homology modeling and docking were used to simulate the binding of DFP and selected delta-lactones in the active sites of Hu SMP-30, Hu PON1, and squid DFPase. Results from molecular modeling studies suggest that differences in metal-ligand coordinations, the hydrophobicity of the binding pockets, and limited space in the binding pocket due to the presence of a loop, are responsible for substrate specificities of these enzymes. Published by Elsevier B.V. C1 [Belinskaya, Tatyana; Pattabiraman, Nagarajan; diTargiani, Robert; Choi, Moonsuk; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ashima.saxena@us.army.mil FU Defense Threat Reduction Agency FX The authors wish to thank Ms. Amy Michels for her assistance in preparation of the manuscript. This research was supported by funding from the Defense Threat Reduction Agency. NR 39 TC 4 Z9 4 U1 2 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-9639 J9 BBA-PROTEINS PROTEOM JI BBA-Proteins Proteomics PD MAY PY 2012 VL 1824 IS 5 BP 701 EP 710 DI 10.1016/j.bbapap.2012.02.007 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 942VD UT WOS:000304077200001 PM 22401958 ER PT J AU Kim, IK Wang, H Weiss, SJ Varadan, VV AF Kim, In Kwang Wang, Huan Weiss, Steven J. Varadan, Vasundara V. TI Embedded Wideband Metaresonator Antenna on a High-Impedance Ground Plane for Vehicular Applications SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Article DE Armor; ceramic; conformal antenna; embedded antenna; high-impedance surface (HIS); low-temperature co-fired ceramic (LTCC) fabrication; metamaterials; resonance behavior; wideband antenna ID DIPOLE ANTENNA; PATCH ANTENNA; PARASITIC ELEMENTS; PERFORMANCE; EFFICIENT; SURFACES; SYSTEMS AB A conformal embedded wideband metaresonator antenna is proposed for military vehicular applications. Meta-materials are artificial materials that exhibit plasmonic resonances with subwavelength sizes of metallic structures. Metaresonator antennas use metamaterial structures as radiators to reduce the size of antennas and design multiband antennas. A small-dipole antenna is placed on a high-impedance ground plane with a conjoined split-ring resonator (SRR). The total volume of the antenna, including the effectively high impedance ground plane, is only 0.51 lambda(0) x 0.41 lambda(0) x 0.05 lambda(0). The embedded multilayer ceramic antenna was fabricated using a low-temperature co-fired ceramic (LTCC) technique and is well suited for embedment in the armor. Very good agreement was obtained between full-wave simulation results and measurements of the reflection coefficient and radiation pattern. C1 [Kim, In Kwang; Varadan, Vasundara V.] Univ Arkansas, Microwave & Opt Lab Imaging & Characterizat, Dept Elect Engn, Fayetteville, AR 72701 USA. [Wang, Huan] Huawei Technol Co Ltd, Shenzhen 518129, Peoples R China. [Weiss, Steven J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Kim, IK (reprint author), Nextivity Inc, San Diego, CA 92128 USA. EM vvvesm@uark.edu FU U.S. Army Research Laboratory [W911QX-10-C-0038] FX Manuscript received August 17, 2011; revised December 20, 2011; accepted January 25, 2012. Date of publication February 28, 2012; date of current version May 9, 2012. The work of I. K. Kim, V. V. Varadan, and H. Wang was supported by the U.S. Army Research Laboratory under Contract W911QX-10-C-0038. The review of this paper was coordinated by Prof. S. K. Chaudhuri. NR 38 TC 4 Z9 4 U1 1 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9545 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD MAY PY 2012 VL 61 IS 4 BP 1665 EP 1672 DI 10.1109/TVT.2012.2189254 PG 8 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA 943AY UT WOS:000304094000017 ER PT J AU Lange, RT Iverson, GL Brubacher, JR Madler, B Heran, MK AF Lange, Rael T. Iverson, Grant L. Brubacher, Jeffrey R. Maedler, Burkhard Heran, Manraj K. TI Diffusion Tensor Imaging Findings Are Not Strongly Associated With Postconcussional Disorder 2 Months Following Mild Traumatic Brain Injury SO JOURNAL OF HEAD TRAUMA REHABILITATION LA English DT Article DE corpus callosum; diffusion tensor imaging; mild traumatic brain injury; postconcussion symptoms ID GOOD OLD DAYS; CORPUS-CALLOSUM; AXONAL INJURY; HEAD-INJURY; BASE RATES; SYMPTOMS; MODERATE; ABNORMALITIES; INDIVIDUALS; PERFORMANCE AB Objective: To examine the relation between diffusion tensor imaging (DTI) of the corpus callosum and postconcussion symptom reporting following mild traumatic brain injury (MTBI). Participants: Sixty patients with MTBI and 34 patients with orthopedic/soft-tissue injuries (Trauma Controls) prospectively enrolled from consecutive admissions to a level 1 trauma center. Procedure: Diffusion tensor imaging of the corpus callosum was undertaken using a Phillips 3T scanner at 6 to 8 weeks postinjury. Participants also completed a postconcussion symptom checklist. The MTBI group was divided into 2 subgroups based on the International Classification of Diseases, Tenth Revision symptom criteria for postconcussion disorder (PCD): PCD Present (n = 21), PCD Absent (n = 39). Main Outcome Measures: Measures of fractional anisotropy and mean diffusivity for the genu, body, and splenium of the corpus callosum. Participants also completed the British Columbia Post-Concussion Symptom Inventory. Results: The MTBI group reported more postconcussion symptoms than the trauma controls. There were no significant differences between MTBI and trauma control groups on all DTI measures. In the MTBI sample, there were no significant differences on all DTI measures between those who did and did not meet the International Classification of Diseases, Tenth Revision research criteria for postconcussion disorder. Conclusions: These data do not support an association between white matter integrity in the corpus callosum and self-reported postconcussion syndrome 6 to 8 weeks post-MTBI. C1 [Lange, Rael T.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [Lange, Rael T.; Iverson, Grant L.; Brubacher, Jeffrey R.; Maedler, Burkhard; Heran, Manraj K.] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Brubacher, Jeffrey R.; Heran, Manraj K.] Vancouver Gen Hosp, Vancouver, BC, Canada. [Brubacher, Jeffrey R.] Ctr Clin Epidemiol & Evaluat, Vancouver, BC, Canada. RP Lange, RT (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Bldg 1,Room B207,6900 Georgia Ave NW, Washington, DC 20307 USA. EM rlange@dvbic.org FU Alcohol Beverage Medical Research Foundation; Canadian Institutes of Health Research [MOP-89374] FX This study was supported, in part, by a research grant from the Alcohol Beverage Medical Research Foundation and the Canadian Institutes of Health Research (MOP-89374). NR 47 TC 34 Z9 34 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0885-9701 J9 J HEAD TRAUMA REHAB JI J. Head Trauma Rehabil. PD MAY-JUN PY 2012 VL 27 IS 3 BP 188 EP 198 DI 10.1097/HTR.0b013e318217f0ad PG 11 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 941CV UT WOS:000303941500007 PM 21642855 ER PT J AU Lin, Y Garcia, LA AF Lin, Y. Garcia, L. A. TI Assessing the Impact of Irrigation Return Flow on River Salinity for Colorado's Arkansas River Valley SO JOURNAL OF IRRIGATION AND DRAINAGE ENGINEERING-ASCE LA English DT Article DE Irrigation return flow; River salinity; Response function; Hydro-chemical reaction; Deep percolation; Tailwater; Groundwater ID STREAM-AQUIFER SYSTEM; MODELING FLOW; TRANSPORT AB A river salinity model has been developed on the 21 major canal areas in the lower Arkansas River Basin in Colorado to address the impact of irrigation return flow on the river. The quantity of the return flow is predicted by constructing response functions for tailwater, canal leakage, and in-field deep percolation so that the spatial and temporal distribution of the return flow can be simulated. A groundwater table surface is generated using water table elevation data from 974 wells in the study area to establish flow paths and travel time for groundwater. The quality of the return flow is predicted by simulating the evapoconcentration process in the root zone soil in which hydro-chemical reactions occur and affect the salinity of in-field deep percolation water. The effects of shallow water table and high soil salinity on crops are simulated to account for the impacts that these two factors have on crop consumptive use. Model calibration and validation over a 192-month period from January 1986 to December 2001 show strong agreement between the observed and simulated values of river flow volume and river salinity. The simulation results show that irrigation return flows, including tailwater and groundwater return flows, significantly increase river quantity, but that groundwater return flow is also a major component of river salinity. There is significant seasonal fluctuation in river salinity and soil water salinity. The increase of soil water salinity from the soil surface to the bottom of the root zone is significant and will cause salt to be loaded to the groundwater. The simulation from 1991-2001 indicates that 20.9% of the 19,944 million m(3) of irrigation water applied to Colorado's lower Arkansas Valley becomes canal leakage, 22.5% is in-field deep percolation, and 22.9% becomes tailwater. This study assesses the effect of reducing agricultural irrigation on river salinity. Consider the scenario of three major canals stopping irrigation and transferring a portion of the curtailed water to off-basin cities with the remaining portion released to the river. The results indicate that, in order not to increase river salinity for downstream reaches, the portion of water transferred to cities should not exceed 50%. C1 [Lin, Y.] US Army Corps Engineers, Sacramento, CA 95814 USA. [Garcia, L. A.] Colorado State Univ, Integrated Decis Support Grp, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. RP Lin, Y (reprint author), US Army Corps Engineers, Sacramento, CA 95814 USA. EM yuanwen.lin@usace.army.mil NR 19 TC 3 Z9 3 U1 3 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9437 J9 J IRRIG DRAIN E-ASCE JI J. Irrig. Drainage Eng-ASCE PD MAY PY 2012 VL 138 IS 5 BP 406 EP 415 DI 10.1061/(ASCE)IR.1943-4774.0000410 PG 10 WC Agricultural Engineering; Engineering, Civil; Water Resources SC Agriculture; Engineering; Water Resources GA 940ZJ UT WOS:000303931300002 ER PT J AU Sarker, BR Baylot, EA Green, JG Biswas, P AF Sarker, Bhaba R. Baylot, E. Alex Green, John G. Biswas, Pablo TI Convoy Movement: Consideration of Turning Geometrics for Selected Vehicle Shapes SO JOURNAL OF TRANSPORTATION ENGINEERING LA English DT Article DE Turning geometry; Intersection; Radius and length of curvature; Convoy movement AB This research is aimed at facilitating the understanding of the restrictions of convoy movement with object shapes as they might apply to ground vehicles maneuvering in a theater-of-operations. Such a theater would include civilian or military disaster evacuation/relief and military security or logistics operations. The goal of the overarching study was first to identify routes for maximal throughput rate that will facilitate the maneuver of a convoy unit omnidirectionally (radially) to different localities at different elapsed times. The focus of this study was to characterize several models for physical boundary conditions. Having done so, they would be used to evaluate the passability of convoy vehicles through streets in an urban environment under different conditions of road geometry, especially at an intersection. Special cases are also evaluated to study the capability of the general models. Models for radius and length of curvature are also developed for different traffic geometrics such as intersections, curvature, and a circular island in an intersection. In all modeling approaches, detailed descriptions of the derivations are illustrated with numerical examples and figures. These road geometrics will help estimate the reduction of traffic speed for deployment of ground vehicles. DOI: 10.1061/(ASCE)TE.1943-5436.0000359. (C) 2012 American Society of Civil Engineers. C1 [Sarker, Bhaba R.] Louisiana State Univ, Dept Mech & Ind Engn, Baton Rouge, LA 70803 USA. [Baylot, E. Alex; Green, John G.] USAC Engineer Res & Dev Ctr, Mobil Syst Branch, Engn Syst & Mat Div, Vicksburg, MS 39180 USA. [Biswas, Pablo] Texas A&M Int Univ, Dept Syst Engn, Laredo, TX 78041 USA. RP Sarker, BR (reprint author), Louisiana State Univ, Dept Mech & Ind Engn, Baton Rouge, LA 70803 USA. EM bsarker@lsu.edu; alex.baylot@usace.army.mil; pablo.biswas@tamiu.com RI Biswas, Pablo/B-4835-2012 FU U.S. Army Corps of Engineers and Research Development Center, Vicksburg, MS [DAAD19-02-D-0001] FX The authors are thankful to three anonymous referees and the editor for their critical comments and valuable suggestions to improve the presentation of the manuscript. This research was funded by the Summer Faculty Fellowship Program (SFFP) Contract No. DAAD19-02-D-0001 at the U.S. Army Corps of Engineers and Research Development Center, Vicksburg, MS. NR 17 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-947X EI 1943-5436 J9 J TRANSP ENG JI J. Transp. Eng. PD MAY PY 2012 VL 138 IS 5 BP 502 EP 511 DI 10.1061/(ASCE)TE.1943-5436.0000359 PG 10 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA 941BO UT WOS:000303937200002 ER PT J AU Martin, SK Savant, G McVan, DC AF Martin, S. Keith Savant, Gaurav McVan, Darla C. TI Two-Dimensional Numerical Model of the Gulf Intracoastal Waterway near New Orleans SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Adaptive hydraulics; Sector gate; Lake Borgne surge barrier AB Two-dimensional tidal flows within the Lake Pontchartrain-Lake Borgne area (Louisiana) are simulated to assess the effects of the surge protection structure on the Gulf Intracoastal Waterway (GIWW) on navigation conditions. The region of interest is modeled with a shallow-water, depth-averaged, finite-element model. The water levels and discharge are analyzed at a location in the GIWW to ascertain model behavior. It is shown that the presence of the structure produces infrequent increases in velocities in the GIWW, which can be mitigated by a proposed structure near Lake Pontchartrain. DOI: 10.1061/(ASCE)WW.1943-5460.0000119. (C) 2012 American Society of Civil Engineers. C1 [Martin, S. Keith; Savant, Gaurav; McVan, Darla C.] US Army Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS 39183 USA. [Savant, Gaurav] Dynam Solut LLC, Grand Rapids, MI USA. RP Martin, SK (reprint author), US Army Corps Engineers, Coastal & Hydraul Lab, Vicksburg, MS 39183 USA. EM keith.martin@usace.army.mil FU USACE Hurricane Protection Office; U.S. Army ERDC, Coastal and Hydraulics Laboratory; U.S. Army FX The experiments described and the results presented were obtained from research sponsored by the USACE Hurricane Protection Office and the U.S. Army ERDC, Coastal and Hydraulics Laboratory. Permission was granted by the Chief of Engineers to publish this information.; The authors would like to specifically acknowledge Maj. Jeremy Chapman, U.S. Army, and Ms. Angela Desoto-Duncan, USACE Hurricane Protection Office, without whose support this work would not have been possible. The authors would also like to gratefully acknowledge Dr. Zeki Demirbilek for his helpful comments. NR 11 TC 4 Z9 4 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY-JUN PY 2012 VL 138 IS 3 BP 236 EP 245 DI 10.1061/(ASCE)WW.1943-5460.0000119 PG 10 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 940ZY UT WOS:000303932800006 ER PT J AU Farhadzadeh, A Kobayashi, N Gravens, MB AF Farhadzadeh, Ali Kobayashi, Nobuhisa Gravens, Mark B. TI Effect of Breaking Waves and External Current on Longshore Sediment Transport SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Longshore current; Longshore sediment transport; Breaking waves; Tidal current AB The effects of external currents on the longshore current and sediment transport in the surf zone are examined using the cross-shore numerical model CSHORE, which is extended to include the alongshore pressure gradient term in the longshore momentum equation and to allow oblique waves in the swash zone on a beach. The extended CSHORE is compared with five tests conducted in a wave basin with a recirculation system. The cross-shore variations of the longshore current and sediment-transport rate are predicted fairly well for the cases of no and favorable pressure gradients. The cases of adverse and time-varying pressure gradients are computed to extrapolate the experimental results for wider applications. DOI: 10.1061/(ASCE)WW.1943-5460.0000123. (C) 2012 American Society of Civil Engineers. C1 [Farhadzadeh, Ali] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Kobayashi, Nobuhisa] Univ Delaware, Ctr Appl Coastal Res, Newark, DE 19716 USA. [Gravens, Mark B.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Farhadzadeh, A (reprint author), Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. EM alif@udel.edu FU U.S. Army Corps of Engineers, Coastal and Hydraulic Laboratory [W912BU-09-R-0031, W912HZ-10-P-0234] FX This study was supported by the U.S. Army Corps of Engineers, Coastal and Hydraulic Laboratory under Contract Nos. W912BU-09-R-0031 and W912HZ-10-P-0234. NR 7 TC 3 Z9 3 U1 1 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY-JUN PY 2012 VL 138 IS 3 BP 256 EP 260 DI 10.1061/(ASCE)WW.1943-5460.0000123 PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 940ZY UT WOS:000303932800008 ER PT J AU Hughes, SA Shaw, JM Howard, IL AF Hughes, Steven A. Shaw, Justin M. Howard, Isaac L. TI Earthen Levee Shear Stress Estimates for Combined Wave Overtopping and Surge Overflow SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article DE Leeves; Wave overtopping; Shear stress; Physical model; Steady overflow; Laboratory study; Peak shear stress AB A total of 25 small-scale laboratory experiments simulating combined wave overtopping and storm-surge overflow on a trapezoidal levee were conducted at a nominal prototype-to-model scale of N-L=25. Time series measurements of irregular and unsteady flow thickness and velocity were acquired at two locations on the landward-side, 1V : 3H slope. These measurements were used to calculate the time series of instantaneous shear stress representing the average over a 4.8-m-long (prototype scale) levee slope between the two measurement locations. Empirical relationships are presented for estimating the mean shear stresses for steady overflow and for combined wave and surge overtopping. For the latter case, additional formulas are given for estimating representative parameters of the irregular shear stress peaks associated with individual overtopping waves. The collected data were intended primarily for the design of rapidly deployable levee armoring systems; however, the data could also be used to evaluate the erosion of soil or vegetated levees and dikes. DOI: 10.1061/(ASCE)WW.1943-5460.0000135. (C) 2012 American Society of Civil Engineers. C1 [Hughes, Steven A.] Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. [Hughes, Steven A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Shaw, Justin M.] CH Fenstermaker & Associates Inc, Lafayette, LA 70508 USA. [Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA. RP Hughes, SA (reprint author), Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. EM steven.a.hughespe@gmail.com FU Mississippi State University [70015]; Department of Homeland Security at the Department of Energy's Oak Ridge National Laboratory FX The research described and the results presented in this paper, unless otherwise noted, were obtained with support from the research project titled "Increasing Community Disaster Resilience Through Targeted Strengthening of Critical Infrastructure at Mississippi State University," under project number 70015 and principal investigator Isaac L. Howard. This research was funded by the Department of Homeland Security, which sponsored the Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory. Permission was granted by Headquarters, U. S. Army Corps of Engineers, to publish this information. Special thanks to Hugh Acuff, Julie Cohen, and Tim Nisley for their careful and critical support of the laboratory experiments. NR 16 TC 2 Z9 2 U1 0 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAY-JUN PY 2012 VL 138 IS 3 BP 267 EP 273 DI 10.1061/(ASCE)WW.1943-5460.0000135 PG 7 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 940ZY UT WOS:000303932800010 ER PT J AU Szu, H Hsu, C Jenkins, J Willey, J Landa, J AF Szu, Harold Hsu, Charles Jenkins, Jeffrey Willey, Jefferson Landa, Joseph TI Capturing significant events with neural networks SO NEURAL NETWORKS LA English DT Article DE Compressive sensing; Associative memory; Human visual system; Compressive video sampling ID CORTEX AB Smartphone video capture and transmission to the Web contributes to data pollution. In contrast, mammalian eyes sense all, capture only significant events, allowing us vividly recall the causalities. Likewise in our videos, we wish to skip redundancies and keep only significantly differences, as determined by real-time local medium filters. We construct a Picture Index (PI) of one's (center of gravity changes) among zeros (no changes) as Motion Organized Sparseness (MOS). Only non-overlapping time-ordered PI pair is admitted in the outer-product Associative Memory (AM). Another outer product between PI and its image builds Hetero-AM (HAM) for fault tolerant retrievals. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Szu, Harold; Jenkins, Jeffrey] USA, NVESD, Ft Belvoir, VA USA. [Hsu, Charles] Trident Syst Inc, Fairfax, VA USA. [Willey, Jefferson] USN, Res Lab, Washington, DC 20375 USA. [Landa, Joseph] Briartek Inc, Alexandria, VA USA. RP Szu, H (reprint author), USA, NVESD, Ft Belvoir, VA USA. EM szuharoldh@gmail.com NR 24 TC 12 Z9 12 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0893-6080 J9 NEURAL NETWORKS JI Neural Netw. PD MAY PY 2012 VL 29-30 BP 1 EP 7 DI 10.1016/j.neunet.2012.01.003 PG 7 WC Computer Science, Artificial Intelligence; Neurosciences SC Computer Science; Neurosciences & Neurology GA 944YL UT WOS:000304239600003 PM 22402410 ER PT J AU Patregnani, JT Borgman, MA Maegele, M Wade, CE Blackbourne, LH Spinella, PC AF Patregnani, Jason T. Borgman, Matthew A. Maegele, Marc Wade, Charles E. Blackbourne, Lorne H. Spinella, Philip C. TI Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitals SO PEDIATRIC CRITICAL CARE MEDICINE LA English DT Article DE base deficit; coagulopathy; combat hospitals; INR; shock; trauma ID RED-BLOOD-CELLS; INITIAL BASE DEFICIT; ACTIVATED FACTOR-VII; PEDIATRIC TRAUMA; UNIVERSAL LEUKOREDUCTION; INDEPENDENT PREDICTOR; MASSIVE TRANSFUSION; TISSUE OXYGENATION; ORGAN DYSFUNCTION; INTENSIVE-CARE AB Objective: In adults, early traumatic coagulopathy and shock are both common and independently associated with mortality. There are little data regarding both the incidence and association of early coagulopathy and shock on outcomes in pediatric patients with traumatic injuries. Our objective was to determine whether coagulopathy and shock on admission are independently associated with mortality in children with traumatic injuries. Methods: A retrospective review of the Joint Theater Trauma Registry from U.S. combat support hospitals in Iraq and Afghanistan from 2002 to 2009 was performed. Coagulopathy was defined as an international normalized ratio of >= 1.5 and shock as a base deficit of >= 6. Laboratory values were measured on admission. Primary outcome was inhospital mortality. Univariate analyses were performed on all admission variables followed by reverse stepwise multivariate logistic regression to determine independent associations. Setting: Combat support hospitals in Iraq and Afghanistan. Patients: Patients <18 yrs of age with Injury Severity Score, international normalized ratio, base deficit, and inhospital mortality were included. Of 1998 in the cohort, 744 (37%) had a complete set of data for analysis. Intervention: None. Measurements and Main Results: The incidence of early coagulopathy and shock were 27% and 38.3% and associated with mortality of 22% and 16.8%, respectively. After multivariate logistic regression, early coagulopathy had an odds ratio of 2.2 (95% confidence interval 1.1-4.5) and early shock had an odds ratio of 3.0 (95% confidence interval 1.2-7.5) for mortality. Patients with coagulopathy and shock had an odds ratio of 3.8 (95% confidence interval 2.0-7.4) for mortality. Conclusions: In children with traumatic injuries treated at combat support hospitals, coagulopathy and shock on admission are common and independently associated with a high incidence of inhospital mortality. Future studies are needed to determine whether more rapid and accurate methods of measuring coagulopathy and shock as well as if early goal-directed treatment of these states can improve outcomes in children. (Pediatr Crit Care Med 2012; 13:273-277) C1 [Patregnani, Jason T.] Connecticut Childrens Med Ctr, Hartford, CT USA. [Borgman, Matthew A.] Childrens Hosp, Boston, MA 02115 USA. [Maegele, Marc] Brooke Army Med Ctr, San Antonio, TX USA. [Maegele, Marc] Univ Cologne, Med Ctr, D-50931 Cologne, Germany. Univ Texas Houston, Ctr Translat Injury Res, Houston, TX USA. [Blackbourne, Lorne H.; Spinella, Philip C.] USA, Inst Surg Res, San Antonio, TX USA. [Spinella, Philip C.] Blood Syst Res Inst, San Francisco, CA USA. [Spinella, Philip C.] Washington Univ, St Louis, MO USA. RP Patregnani, JT (reprint author), Connecticut Childrens Med Ctr, Hartford, CT USA. EM Jpatregnani@gmail.com RI Borgman, Matthew/L-9477-2015 OI Borgman, Matthew/0000-0002-2008-7380 NR 45 TC 29 Z9 29 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1529-7535 J9 PEDIATR CRIT CARE ME JI Pediatr. Crit. Care Med. PD MAY PY 2012 VL 13 IS 3 BP 273 EP 277 DI 10.1097/PCC.0b013e31822f1727 PG 5 WC Critical Care Medicine; Pediatrics SC General & Internal Medicine; Pediatrics GA 941SM UT WOS:000303984800015 PM 21926654 ER PT J AU Cardellina, JH Roxas-Duncan, VI Montgomery, V Eccard, V Campbell, Y Hu, X Khavrutskii, I Tawa, GJ Wallqvist, A Gloer, JB Phatak, NL Holler, U Soman, AG Joshi, BK Hein, SM Wicklow, DT Smith, LA AF Cardellina, John H., II Roxas-Duncan, Virginia I. Montgomery, Vicki Eccard, Vanessa Campbell, Yvette Hu, Xin Khavrutskii, Ilja Tawa, Gregory J. Wallqvist, Anders Gloer, James B. Phatak, Nisarga L. Hoeller, Ulrich Soman, Ashish G. Joshi, Biren K. Hein, Sara M. Wicklow, Donald T. Smith, Leonard A. TI Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A SO ACS MEDICINAL CHEMISTRY LETTERS LA English DT Article DE in silico screen; botulinum neurotoxin serotype A; natural products; chaetochromin; talaroderxine; binding free energy; thermodynamic integration ID BIS(NAPHTHO-GAMMA-PYRONE) DERIVATIVES; SCORING FUNCTION; CHAETOCHROMIN; PREDICTION; CHAETOMIUM; CLASSIFICATION; IDENTIFICATION; METABOLITES; VALIDATION; SOFTWARE AB An in silico screen of the NIH Molecular Library Small Molecule Repository (MLSMR) of similar to 350000 compounds and confirmatory bioassays led to identification of chaetochromin A (1) as an inhibitor of botulinum neurotoxin serotype A (BoNT A). Subsequent acquisition and testing of analogues of 1 uncovered two compounds, talaroderxines A (2) and B (3), with improved activity. These are the first fungal metabolites reported to exhibit BoNT/A inhibitory activity. C1 [Cardellina, John H., II; Roxas-Duncan, Virginia I.; Montgomery, Vicki; Eccard, Vanessa; Campbell, Yvette] USA, Med Res Inst Infect Dis, Div Integrated Toxicol, Frederick, MD 21702 USA. [Hu, Xin; Khavrutskii, Ilja; Tawa, Gregory J.; Wallqvist, Anders] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Frederick, MD 21702 USA. [Gloer, James B.; Phatak, Nisarga L.; Hoeller, Ulrich; Soman, Ashish G.; Joshi, Biren K.; Hein, Sara M.] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA. [Wicklow, Donald T.] USDA, Agr Res Serv, Bacterial Foodborne Pathogens & Mycol Res Unit, Peoria, IL 61604 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Div Integrated Toxicol, Frederick, MD 21702 USA. EM Leonard.a.Smith1@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU Defense Threat Reduction Agency, JSTO-CBD [3.10037_07_RD_B]; U.S. Department of Defense (DOD) under the High Performance Computing Software Applications Institutes initiative; National Science Foundation [CHE-11011847] FX This work was supported by a grant awarded to L.A.S. from the Defense Threat Reduction Agency, JSTO-CBD Project Number 3.10037_07_RD_B. This work was also sponsored by the U.S. Department of Defense (DOD) High Performance Computing Modernization Program under the High Performance Computing Software Applications Institutes initiative. Research at the University of Iowa was supported by a grant from the National Science Foundation (CHE-11011847). NR 34 TC 14 Z9 14 U1 1 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-5875 J9 ACS MED CHEM LETT JI ACS Med. Chem. Lett. PD MAY PY 2012 VL 3 IS 5 BP 387 EP 391 DI 10.1021/ml200312s PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 939DC UT WOS:000303786400009 PM 24900483 ER PT J AU Dunn, D Mansfield, L Schwope, R AF Dunn, D. Mansfield, L. Schwope, R. TI Corner Shots in Abdominal and Pelvis CT Examinations: Findings at the Periphery of the Image and Search Pattern SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Roentgen-Ray-Society CY APR 29-MAY 04, 2012 CL Vancouver, CANADA SP Amer Roentgen Ray Soc C1 [Dunn, D.; Mansfield, L.; Schwope, R.] Brooke Army Med Ctr, San Antonio, TX USA. EM liem_mansfield@hotmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2012 VL 198 IS 5 SU S PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 937OI UT WOS:000303667400460 ER PT J AU Kessler, R Mansfield, L AF Kessler, R. Mansfield, L. TI Vascular Anatomy of the Calcaneus and Its Implication in Stress Fractures and Avascular Necrosis of the Calcaneus SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Roentgen-Ray-Society CY APR 29-MAY 04, 2012 CL Vancouver, CANADA SP Amer Roentgen Ray Soc C1 [Kessler, R.; Mansfield, L.] Brooke Army Med Ctr, San Antonio, TX USA. EM liem_mansfield@hotmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2012 VL 198 IS 5 SU S PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 937OI UT WOS:000303667400504 ER PT J AU Wiedenhoefer, J Harston, C James, B AF Wiedenhoefer, J. Harston, C. James, B. TI Breast MRI: An Alternative to Stereotactic Biopsy for Management of Developing Mammographic Asymmetries SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Roentgen-Ray-Society CY APR 29-MAY 04, 2012 CL Vancouver, CANADA SP Amer Roentgen Ray Soc C1 [Wiedenhoefer, J.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. [Harston, C.] Lexington Clin, Lexington, KY USA. [James, B.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. EM chad.harston@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2012 VL 198 IS 5 SU S PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 937OI UT WOS:000303667400245 ER PT J AU Causey, MW Steele, SR Farris, Z Lyle, DS Beitler, AL AF Causey, Marlin Wayne Steele, Scott R. Farris, Zachary Lyle, David S. Beitler, Alan L. TI An assessment of different scoring systems in cirrhotic patients undergoing nontransplant surgery SO AMERICAN JOURNAL OF SURGERY LA English DT Article; Proceedings Paper CT Annual Meeting of the Society-of-Academic-Research-and-Surgery CY JAN 10-12, 2007 CL Robinson Coll, Cambridge, ENGLAND SP Soc Acad Res & Surg HO Robinson Coll DE Childs-Turcotte-Pugh; MELD-Na; MELD; Cirrhosis; Surgery ID STAGE LIVER-DISEASE; MELD SCORES; ABDOMINAL OPERATIONS; SURVIVAL; MODEL; ALLOCATION; RISK; PUGH AB BACKGROUND: Determining surgical risk in cirrhotic patients is difficult and multiple scoring systems have sought to quantify this risk. The purpose of our study was to assess the impact of Childs-Turcotte-Pugh (CTP), Model of End-Stage Liver Disease (MELD), and MELD-Sodium (MELD-Na) scores on postoperative morbidity and mortality for cirrhotic patients undergoing nontransplant surgery. METHODS: We performed a single-center retrospective review of all cirrhotic patients who underwent nontransplant surgery under general anesthesia over a 6-year period of time to analyze outcomes using the 3 scoring systems. RESULTS: Sixty-four cirrhotic patients (mean age, 57 y; 62 men) underwent nontransplant surgery under general anesthesia. A CTP score of >= 7.5 was associated with an 8.3-fold increased risk of 30-day morbidity, a MELD score of >= 14.5 was associated with a 5.4-fold increased risk of 3-month mortality, and a MELD-Na score >= 14.5 was associated with a 4.5-fold increased risk of 1-year mortality. Emergent surgery, the presence of ascites, and low serum sodium level were associated significantly with morbidity and 1-year mortality. CONCLUSIONS: The major strengths of the 3 scoring systems are for CTP in estimating 30-day morbidity, MELD for estimating 3-month mortality, and MELD-Na for estimating 1-year mortality. Published by Elsevier Inc. C1 [Beitler, Alan L.] Keller Army Community Hosp, Dept Surg, West Point, NY 10996 USA. [Causey, Marlin Wayne; Steele, Scott R.] Madigan Hlth Syst, Madigan Army Med Syst, Dept Surg, Tacoma, WA USA. [Farris, Zachary] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA. [Lyle, David S.] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. RP Beitler, AL (reprint author), Keller Army Community Hosp, Dept Surg, 900 Washington Rd, West Point, NY 10996 USA. EM Alan.Beitler@amedd.army.mil NR 16 TC 8 Z9 8 U1 0 U2 0 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD MAY PY 2012 VL 203 IS 5 BP 589 EP 593 DI 10.1016/j.amjsurg.2012.01.009 PG 5 WC Surgery SC Surgery GA 940ET UT WOS:000303873500011 PM 22521048 ER PT J AU Jacobson, IG Horton, JL Smith, B Wells, TS Boyko, EJ Lieberman, HR Ryan, MAK Smith, TC AF Jacobson, Isabel G. Horton, Jaime L. Smith, Besa Wells, Timothy S. Boyko, Edward J. Lieberman, Harris R. Ryan, Margaret A. K. Smith, Tyler C. CA Millennium Cohort Study Team TI Bodybuilding, Energy, and Weight-Loss Supplements Are Associated With Deployment and Physical Activity in U.S. Military Personnel SO ANNALS OF EPIDEMIOLOGY LA English DT Article DE Dietary Supplements; Exercise; Military Personnel ID MILLENNIUM COHORT; DIETARY-SUPPLEMENTS; COGNITIVE PERFORMANCE; DRINK CONSUMPTION; MAJOR DEPRESSION; MENTAL-DISORDERS; COLLEGE-STUDENTS; NATIONAL-SURVEY; SLEEP DURATION; UNITED-STATES AB PURPOSE: The characteristics of U.S. military personnel who use dietary supplements have not been well described. This study aimed to determine whether deployment experience and physical activity were associated with the use of bodybuilding, energy, or weight-loss supplement among U.S. military personnel. METHODS: Self-reported data from active-duty, Reserve, and National Guard participants of the Millennium Cohort Study collected from 2007-2008 (n = 106,698) on supplement use, physical activity, and other behavioral data were linked with deployment and demographic data. We used multivariable logistic regression sex-stratified models to compare the adjusted odds of each type of supplement use among those with deployment experience in support of operations in Iraq or Afghanistan and those engaged in aerobic or strength-training activities. RESULTS: Overall, 46.7% of participants reported using at least one type of supplement, and 22.0% reported using multiple supplements. Male deployers were more likely to use bodybuilding supplements, whereas female deployers were more likely to use weight-loss supplements. Physically active and younger subjects reported all types of supplement use. Men and women reporting 5 or less hours of sleep per night were more likely to use energy supplements. CONCLUSIONS: The high prevalence of supplement use and important characteristics found to be associated with their use, including deployment, physical activity, and suboptimal sleep, suggest focus areas for future research and adverse event monitoring. Ann Epidemiol 2012;22:318-330. (C) 2012 Elsevier Inc. All rights reserved. C1 [Jacobson, Isabel G.; Horton, Jaime L.; Smith, Besa; Smith, Tyler C.] USN, Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. [Wells, Timothy S.] Res Lab, Wright Patterson AFB, OH USA. [Boyko, Edward J.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Ryan, Margaret A. K.] USN, Hosp Camp Pendleton, Camp Pendleton, CA USA. RP Jacobson, IG (reprint author), USN, Hlth Res Ctr, Deployment Hlth Res Dept, San Diego, CA 92106 USA. EM isabel.jacobson@med.navy.mil FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD; U.S. Army Medical Research and Materiel Command, Fort Detrick, MD; VA Puget Sound Health Care System; Department of Defense [60002] FX The authors thank Paul Amoroso, MD, MPH, from the Madigan Army Medical Center, Tacoma, WA; Gary Gackstetter, DVM, MPH, PhD, from Analytic Services, Inc., Arlington, VA; Tomoko Hooper, MD, MPH, from Uniformed Services University of the Health Sciences, Bethesda, MD. In addition, they thank Melissa Bagnell, MPH, Gina Creaven, MBA, Nancy Crum-Cianflone, MD, MPH, James Davies, Nisara Granado, MPH, PhD, Dennis Hernando, Kelly Jones, MPH, Cynthia LeardMann, MPH, William Lee, Travis Leleu, Gordon Lynch, Hope McMaster, MA, PhD, Amanda Pietrucha, MPH, Teresa Powell, MS, Amber Seelig, MPH, Beverly Sheppard, Katherine Snell, Steven Speigle, Kari Sausedo, MA, Martin White, MPH, James Whitmer, and Charlene Wong, MPH, from the Deployment Health Research Department, Naval Health Research Center, San Diego, CA. They thank Scott L. Seggerman from the Management Information Division, Defense Manpower Data Center, Monterey, CA and also thank Michelle LeWark from the Naval Health Research Center. Finally, they thank the professionals from the U.S. Army Medical Research and Materiel Command, especially those from the Military Operational Medicine Research Program, Fort Detrick, MD. The support of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD is appreciated. The Millennium Cohort Study is funded through the Military Operational Medicine Research Program of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. The funding organization had no role in the design and conduct of the study; collection, analysis, or preparation of data; or preparation, review, or approval of the manuscript. Resources from the VA Puget Sound Health Care System supported Dr. Boyko's involvement in this research. This represents report 11-07, supported by the Department of Defense, under work unit no. 60002. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of the Army, Department of the Air Force, Department of Defense, Department of Veterans Affairs, or the U.S. Government. Approved for public release; distribution is unlimited. This research has been conducted in compliance with all applicable federal regulations governing protection of human subjects in research (Protocol NHRC.2000.0007). NR 61 TC 26 Z9 26 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1047-2797 J9 ANN EPIDEMIOL JI Ann. Epidemiol. PD MAY PY 2012 VL 22 IS 5 BP 318 EP 330 DI 10.1016/j.annepidem.2012.02.017 PG 13 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 939CF UT WOS:000303783900003 PM 22445519 ER PT J AU Wootton, R Geissbuhler, A Jethwani, K Kovarik, C Person, DA Vladzymyrskyy, A Zanaboni, P Zolfo, M AF Wootton, Richard Geissbuhler, Antoine Jethwani, Kamal Kovarik, Carrie Person, Donald A. Vladzymyrskyy, Anton Zanaboni, Paolo Zolfo, Maria TI Long-running telemedicine networks delivering humanitarian services: experience, performance and scientific output SO BULLETIN OF THE WORLD HEALTH ORGANIZATION LA English DT Article ID LOW-COST TELEMEDICINE; MESSAGE-ROUTING SYSTEM; LOW-RESOURCE SETTINGS; FORWARD TELEMEDICINE; DEVELOPING-COUNTRIES; MEDICAL-EDUCATION; DEVELOPING-WORLD; PACIFIC ISLANDS; INTERNET; CONSULTATIONS AB Objective To summarize the experience, performance and scientific output of long-running telemedicine networks delivering humanitarian services. Methods Nine long-running networks those operating for five years or more were identified and seven provided detailed information about their activities, including performance and scientific output. Information was extracted from peer-reviewed papers describing the networks' study design, effectiveness, quality, economics, provision of access to care and sustainability. The strength of the evidence was scored as none, poor, average or good. Findings The seven networks had been operating for a median of 11 years (range: 5-15). All networks provided clinical tele-consultations for humanitarian purposes using store-and-forward methods and five were also involved in some form of education. The smallest network had 15 experts and the largest had more than 500.The clinical caseload was 50 to 500 cases a year. A total of 59 papers had been published by the networks, and 44 were listed in Medline. Based on study design, the strength of the evidence was generally poor by conventional standards (e.g. 29 papers described non-controlled clinical series). Over half of the papers provided evidence of sustainability and improved access to care. Uncertain funding was a common risk factor. Conclusion Improved collaboration between networks could help attenuate the lack of resources reported by some networks and improve sustainability. Although the evidence base is weak, the networks appear to offer sustainable and clinically useful services. These findings may interest decision-makers in developing countries considering starting, supporting or joining similar telemedicine networks. C1 [Wootton, Richard; Zanaboni, Paolo] Univ Hosp N Norway, Norwegian Ctr Integrated Care & Telemed, N-9038 Tromso, Norway. [Geissbuhler, Antoine] Univ Geneva, Dept Radiol & Med Informat, Geneva, Switzerland. [Jethwani, Kamal] Ctr Connected Hlth, Boston, MA USA. [Kovarik, Carrie] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA. [Person, Donald A.] Tripler Army Med Ctr, Pacific Isl Hlth Care Project, Honolulu, HI 96859 USA. [Vladzymyrskyy, Anton] Donetsk Natl Med Univ, Donetsk, Ukraine. [Zolfo, Maria] Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium. RP Wootton, R (reprint author), Univ Hosp N Norway, Norwegian Ctr Integrated Care & Telemed, N-9038 Tromso, Norway. EM r_wootton@pobox.com RI Wootton, Richard/F-7609-2014; Vladzymyrskyy, Anton/D-1447-2017 OI Wootton, Richard/0000-0002-2666-3596; Vladzymyrskyy, Anton/0000-0002-2990-7736 NR 52 TC 12 Z9 13 U1 0 U2 7 PU WORLD HEALTH ORGANIZATION PI GENEVA 27 PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND SN 0042-9686 J9 B WORLD HEALTH ORGAN JI Bull. World Health Organ. PD MAY PY 2012 VL 90 IS 5 BP 341 EP 347 DI 10.2471/BLT.11.099143 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 939CO UT WOS:000303784900008 PM 22589567 ER PT J AU Eide, RP Asplund, CA AF Eide, Richard P., III Asplund, Chad A. TI Altitude Illness: Update on Prevention and Treatment SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID ACUTE MOUNTAIN-SICKNESS; PLACEBO-CONTROLLED TRIAL; PULMONARY-EDEMA; DOUBLE-BLIND; GINKGO-BILOBA; IRON SUPPLEMENTATION; RANDOMIZED-TRIAL; ACETAZOLAMIDE; PROPHYLAXIS; DEXAMETHASONE AB Altitude illness is a broad category of disease encompassing acute mountain sickness (AMS), high-altitude cerebral edema (HACE), and high-altitude pulmonary edema (HAPE) that can affect persons who travel to altitude without adequate acclimatization. Initial symptoms of AMS and the more serious HACE or HAPE can be subtle, and it is important that the practitioner be able to recognize and differentiate between these diagnoses because they can progress rapidly and be fatal if untreated. There are well-established criteria and many proven therapies both for prophylaxis and treatment of altitude illness; however, despite intense research efforts, the specific mechanisms of these complex diseases remain elusive. Adequate acclimatization via controlled ascent remains the most important factor in preventing altitude illness, although prophylactic pharmacotherapy also may be useful. Rapid descent remains the most important treatment factor, although treatment at altitude with various therapies is possible for mild cases with adequate resources. C1 [Eide, Richard P., III; Asplund, Chad A.] Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA 30905 USA. RP Asplund, CA (reprint author), Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA 30905 USA. EM chad.asplund@gmail.com NR 50 TC 8 Z9 9 U1 1 U2 21 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD MAY-JUN PY 2012 VL 11 IS 3 BP 124 EP 130 DI 10.1249/JSR.0b013e3182563e7a PG 7 WC Sport Sciences SC Sport Sciences GA 941CB UT WOS:000303939000005 PM 22580489 ER PT J AU Theeler, BJ Flynn, FG Erickson, JC AF Theeler, Brett J. Flynn, Frederick G. Erickson, Jay C. TI Chronic Daily Headache in U.S. Soldiers After Concussion SO HEADACHE LA English DT Article DE mild traumatic brain injury; concussion; posttraumatic headache; military ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; US SOLDIERS; CHRONIC MIGRAINE; POPULATION; IRAQ; EPIDEMIOLOGY; AFGHANISTAN; PREVALENCE; SYMPTOMS AB Objective.-To determine the prevalence and characteristics of, and factors associated with, chronic daily headache (CDH) in U.S. soldiers after a deployment-related concussion. Methods.-A cross-sectional, questionnaire-based study was conducted with a cohort of 978 U.S. soldiers who screened positive for a deployment-related concussion upon returning from Iraq or Afghanistan. All soldiers underwent a clinical evaluation at the Madigan Traumatic Brain Injury Program that included a history, physical examination, 13-item self-administered headache questionnaire, and a battery of cognitive and psychological assessments. Soldiers with CDH, defined as headaches occurring on 15 or more days per month for the previous 3 months, were compared to soldiers with episodic headaches occurring less than 15 days per month. Results.-One hundred ninety-six of 978 soldiers (20%) with a history of deployment-related concussion met criteria for CDH and 761 (78%) had episodic headache. Soldiers with CDH had a median of 27 headache days per month, and 46/196 (23%) reported headaches occurring every day. One hundred seven out of 196 (55%) soldiers with CDH had onset of headaches within 1 week of head trauma and thereby met the time criterion for posttraumatic headache (PTHA) compared to 253/761 (33%) soldiers with episodic headache. Ninety-seven out of 196 (49%) soldiers with CDH used abortive medications to treat headache on 15 or more days per month for the previous 3 months. One hundred thirty out of 196 (66%) soldiers with CDH had headaches meeting criteria for migraine compared to 49% of soldiers with episodic headache. The number of concussions, blast exposures, and concussions with loss of consciousness was not significantly different between soldiers with and without CDH. Cognitive performance was also similar for soldiers with and without CDH. Soldiers with CDH had significantly higher average scores on the posttraumatic stress disorder (PTSD) checklist compared to soldiers with episodic headaches. Forty-one percent of soldiers with CDH screened positive for PTSD compared to only 18% of soldiers with episodic headache. Conclusions.-The prevalence of CDH in returning U.S. soldiers after a deployment-related concussion is 20%, or 4- to 5-fold higher than that seen in the general U.S. population.CDH following a concussion usually resembles chronic migraine and is associated with onset of headaches within the first week after concussion. The mechanism and number of concussions are not specifically associated with CDH as compared to episodic headache. In contrast, PTSD symptoms are strongly associated with CDH, suggesting that traumatic stress may be an important mediator of headache chronification. These findings justify future studies examining strategies to prevent and treat CDH in military service members following a concussive injury. C1 [Theeler, Brett J.] 187th Med Battal, AMEDD Student Detachment, Ft Sam Houston, TX 78234 USA. [Erickson, Jay C.] USA, Med Corps, Madigan Army Med Ctr, Dept Med,Neurol Serv, Austin, TX USA. [Flynn, Frederick G.] Madigan Traumat Brain Injury Program, Ft Lewis, WA USA. RP Theeler, BJ (reprint author), 187th Med Battal, AMEDD Student Detachment, Ft Sam Houston, TX 78234 USA. EM btheeler@hotmail.com NR 24 TC 16 Z9 16 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0017-8748 EI 1526-4610 J9 HEADACHE JI Headache PD MAY PY 2012 VL 52 IS 5 BP 732 EP 738 DI 10.1111/j.1526-4610.2012.02112.x PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 936NA UT WOS:000303595900004 PM 22404747 ER PT J AU Sutorik, AC Gilde, G Swab, JJ Cooper, C Gamble, R Shanholtz, E AF Sutorik, Anthony C. Gilde, Gary Swab, Jeffrey J. Cooper, Christopher Gamble, Robert Shanholtz, Eugene TI The Production of Transparent MgAl2O4 Ceramic Using Calcined Powder Mixtures of Mg(OH)2 and gamma-Al2O3 or AlOOH SO INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY LA English DT Article ID MAGNESIUM ALUMINATE SPINEL; SINTERING BEHAVIOR; ND-YAG; ALKOXIDE; AL2O3 AB Magnesium hydroxide, Mg(OH)2 (both 99% and 99.99% purity grades), gamma-Al2O3, and AlOOH have been investigated for the direct production of transparent MgAl2O4. The highest average in-line transmittance through 3.54 mm thick samples is 84.2 +/- 1.0% at 550 nm, attained by using mixtures of 99.99% pure Mg(OH)2 and gamma-Al2O3. Other formulations exhibited 7780% visible transmission, suggesting that further optimization can improve sample consistency. All samples exhibited a Knoop hardness of similar to 12 GPa, and elastic modulus of similar to 280 GPa. Biaxial flexural strength measurements ranged from 85 to 136 MPa depending on starting materials. C1 [Sutorik, Anthony C.; Gilde, Gary; Swab, Jeffrey J.; Cooper, Christopher; Gamble, Robert; Shanholtz, Eugene] USA, Res Lab, RDRL WMM E, Aberdeen, MD 21005 USA. RP Sutorik, AC (reprint author), USA, Res Lab, RDRL WMM E, Bldg 4600, Aberdeen, MD 21005 USA. EM anthony.sutorik1@us.army.mil NR 26 TC 7 Z9 7 U1 3 U2 22 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1546-542X J9 INT J APPL CERAM TEC JI Int. J. Appl. Ceram. Technol. PD MAY-JUN PY 2012 VL 9 IS 3 BP 575 EP 587 DI 10.1111/j.1744-7402.2011.02679.x PG 13 WC Materials Science, Ceramics SC Materials Science GA 937OJ UT WOS:000303667500012 ER PT J AU Swab, JJ LaSalvia, JC Wereszczak, AA Strong, KT Danna, D Ragan, ME Ritt, PJ AF Swab, Jeffrey J. LaSalvia, Jerry C. Wereszczak, Andrew A. Strong, Kevin T., Jr. Danna, Dominic Ragan, Meredith E. Ritt, Patrick J. TI Knoop Hardness-Apparent Yield Stress Relationship in Ceramics SO INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY LA English DT Article ID BRITTLE SOLIDS; INDENTATION; PLASTICITY; FRACTURE; GLASS AB In Tabor's classical studies of the deformation of metals, the yield stress (Y) and hardness (H) were shown to be related according to H/Y approximate to 3 for complete or fully plastic deformation. Since then it has been anecdotally shown for ceramics that this ratio is <3. Interest exists to explore this further so Hertzian indentation was used to measure the apparent yield stress of numerous ceramics and metals and their results were compared with each material's load-dependent Knoop hardness. The evaluated ceramics included standard reference materials for hardness (silicon nitride and tungsten carbide), silicon carbide, alumina, and glass. Several steel compositions were also tested for comparison. Knoop hardness measurements at 19.6 N (i.e., toward complete or fully plastic deformation), showed that 2 < H/Y < 3 for the metals and 0.8 < H/Y < 1.8 for the glasses and ceramics. Being that H/Y not equal 3 for the ceramics indicates that Tabor's analysis is either not applicable to ceramics or that full plastic deformation is not achieved with a Knoop indentation or both. C1 [Swab, Jeffrey J.; LaSalvia, Jerry C.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wereszczak, Andrew A.] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Strong, Kevin T., Jr.; Danna, Dominic; Ragan, Meredith E.; Ritt, Patrick J.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN 37831 USA. RP Swab, JJ (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jeffrey.j.swab.civ@mail.mil RI Wereszczak, Andrew/I-7310-2016 OI Wereszczak, Andrew/0000-0002-8344-092X FU U.S. Army Tank-Automotive Research, Development and Engineering Center [DE-AC-00OR22725]; UT-Battelle, L.L.C. FX The portion of the work performed at ORNL was conducted under Work for Others funded by the U.S. Army Tank-Automotive Research, Development and Engineering Center, under contract DE-AC-00OR22725 with UT-Battelle, L.L.C. NR 21 TC 5 Z9 5 U1 1 U2 14 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1546-542X J9 INT J APPL CERAM TEC JI Int. J. Appl. Ceram. Technol. PD MAY-JUN PY 2012 VL 9 IS 3 BP 650 EP 655 DI 10.1111/j.1744-7402.2011.02686.x PG 6 WC Materials Science, Ceramics SC Materials Science GA 937OJ UT WOS:000303667500020 ER PT J AU Hogan, BK Wolf, SE Hospenthal, DR D'Avignon, LC Chung, KK Yun, HC Mann, EA Murray, CK AF Hogan, Brian K. Wolf, Steven E. Hospenthal, Duane R. D'Avignon, Laurie C. Chung, Kevin K. Yun, Heather C. Mann, Elizabeth A. Murray, Clinton K. TI Correlation of American Burn Association Sepsis Criteria With the Presence of Bacteremia in Burned Patients Admitted to the Intensive Care Unit SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID INADEQUATE ANTIMICROBIAL TREATMENT; ENTERAL FEEDING INTOLERANCE; CRITICALLY-ILL PATIENTS; CONSENSUS CONFERENCE; MORTALITY; INFECTIONS; PLASMA; PROCALCITONIN; DEFINITIONS; INDICATOR AB Severe burn injury is accompanied by a systemic inflammatory response, making traditional indicators of sepsis both insensitive and nonspecific. To address this, the American Burn Association (ABA) published diagnostic criteria in 2007 to standardize the definition of sepsis in these patients. These criteria include temperature (>39 degrees C or <36 degrees C), progressive tachycardia (>110 beats per minute), progressive tachypnea (>25 breaths per minute not ventilated or minute ventilation >12 L/minute ventilated), thrombocytopenia (<100,000/mu l; not applied until 3 days after initial resuscitation), hyperglycemia (untreated plasma glucose >200 mg/dl, >7 units of insulin/hr intravenous drip, or >25% increase in insulin requirements over 24 hours), and feed intolerance >24 hours (abdominal distension, residuals two times the feeding rate, or diarrhea >2500 ml/day). Meeting >= 3 of these criteria should "trigger" concern for infection. In this initial assessment of the ABA sepsis criteria correlation with infection, the authors evaluated the ABA sepsis criteria's correlation with bacteremia because bacteremia is not associated with inherent issues of diagnosis as occurs with pneumonia or soft tissue infections, and blood cultures are typically obtained due to concern for ongoing infections falling within the definition of "septic." A retrospective electronic records review was performed to evaluate episodes of bacteremia in the United States Army Institute of Research from 2006 through 2007. A total of 196 patients were admitted during the study period who met inclusion criteria. The first positive and negative cultures, if present, from each patient were evaluated. This totaled 101 positive and 181 negative cultures. Temperature, heart rate, insulin resistance, and feed intolerance criteria were significant on univariate analysis. Only heart rate and temperature were found to significantly correlate with bacteremia on multivariate analysis. The receiver operating characteristic curve area for meeting >= 3 ABA sepsis criteria is 0.638 (95% confidence interval 0.573-0.704; P < .001). Among severe burn patients, the ABA trigger for sepsis did not correlate strongly with bacteremia in this retrospective chart review. (J Burn Care Res 2012;33:371-378) C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Hogan, Brian K.; Hospenthal, Duane R.; D'Avignon, Laurie C.; Yun, Heather C.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Hogan, Brian K.; Wolf, Steven E.; Hospenthal, Duane R.; D'Avignon, Laurie C.; Yun, Heather C.; Murray, Clinton K.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Wolf, Steven E.; Chung, Kevin K.; Mann, Elizabeth A.] US Army Inst Surg Res USAISR, San Antonio, TX USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 20 TC 10 Z9 12 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD MAY-JUN PY 2012 VL 33 IS 3 BP 371 EP 378 DI 10.1097/BCR.0b013e3182331e87 PG 8 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 937PE UT WOS:000303669600025 PM 22210056 ER PT J AU Abdul-Aziz, A Bhatt, RT AF Abdul-Aziz, Ali Bhatt, Ramakrishna T. TI Modeling of thermal residual stress in environmental barrier coated fiber reinforced ceramic matrix composites SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE EBC; SiC/SiC composites; residual stress; finite element; barium strontium aluminum silicate; ytterbium disilicate; ytterbium monosilicate; BSAS; Mullite ID SILICON-CARBIDE; OXIDATION; COATINGS; CONDUCTIVITY; STABILITY AB For SiC/SiC composites to replace metallic materials in future turbine engines, prime reliant environmental barrier coatings (EBCs) are required. However, due to the mismatch in thermal expansion and elastic modulus between the substrate and the coating, thermal residual stresses are generated in the coating after processing as well as during exposure to turbine engine operating conditions. The nature and magnitude of the thermal stresses will have a profound effect on the durability and reliability of the EBC. To estimate the magnitude of in-plane (x- and y-directions) and through-the-thickness (z-direction) thermal residual stresses in the coating, a finite element model (FEM) was developed. Using FEM, the residual stresses were predicted for three multilayered EBC systems considered for the SiC/SiC composites: (1) barium strontium aluminum silicate, (2) ytterbium disilicate, and (3) ytterbium monosilicate. Influence of thickness and modulus of the coating layer on the thermal residual stress were modeled. Results indicate that thermal residual stresses in the SiC/SiC composite substrate are compressive and in all the three coatings tensile. Further examination indicates that in the z-direction, tensile stresses in all three systems are negligible, but in-plane tensile stresses can be significant depending on the composition of the constituent layer and the distance from the substrate. Comparison of predicted thermal residual stresses in the three systems shows that the ytterbium monosilicate system has the highest stress (similar to 395 MPa), while the other two systems averaged about 80 MPa in one of the coating layers. A parametric analysis conducted indicates that lowering the modulus of the coating can lower the thermal residual stresses. C1 [Abdul-Aziz, Ali; Bhatt, Ramakrishna T.] NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. [Abdul-Aziz, Ali] Cleveland State Univ, Dept Chem & Biomed Engn, Cleveland, OH 44115 USA. [Bhatt, Ramakrishna T.] USA, Vehicle Technol Directorate, AMSRD ARL VT SG, Cleveland, OH USA. RP Abdul-Aziz, A (reprint author), NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. EM ali.abdul-aziz-1@nasa.gov NR 16 TC 3 Z9 3 U1 5 U2 56 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD MAY PY 2012 VL 46 IS 10 BP 1211 EP 1218 DI 10.1177/0021998311414950 PG 8 WC Materials Science, Composites SC Materials Science GA 940YG UT WOS:000303928400007 ER PT J AU Kelley, AM Athy, JR Cho, TH Erickson, B King, M Cruz, P AF Kelley, Amanda M. Athy, Jeremy R. Cho, Timothy H. Erickson, Bradley King, Melody Cruz, Pedro TI Risk propensity and health risk behaviors in U.S. army soldiers with and without psychological disturbances across the deployment cycle SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article DE Risk propensity; Combat deployment; Health risk behaviors ID POSTTRAUMATIC-STRESS-DISORDER; VENTROMEDIAL PREFRONTAL CORTEX; BECK DEPRESSION INVENTORY; TRAUMATIC BRAIN-INJURY; PSYCHOMETRIC PROPERTIES; MILITARY PERSONNEL; PERSONALITY; COMBAT; AFGHANISTAN; IRAQ AB Anecdotal and preliminary evidence suggests that Soldiers returning from a combat deployment engage in an increased number of health risk behaviors. Three potential factors driving this change were examined in this study; posttraumatic stress disorder (PTSD), concussion and traumatic brain injury (TBI), and perceived invincibility. We studied members of a combat arms brigade one month prior to a deployment to Iraq and approximately one month after their return (N = 319). Participants anonymously completed surveys characterizing attitudes about risk, risk propensity, invincibility, engagement in health risk behaviors, and personality. Using standardized screening instruments, participants were categorized with respect to PTSD and probable TBI. Results suggest that Soldiers engage in more alcohol use and reckless driving behaviors post-deployment. These changes were exaggerated in those who screened positive for PTSD. Perception of one's invincibility and survival skills increased post-deployment thus suggesting that participants felt less susceptible to adverse consequences and more adept at surviving dangerous situations. This study provides documentation of the pattern of health behavior in Soldiers engaged in the deployment cycle. Our findings suggest increases in the number of risks Soldiers' engage in post-deployment are not limited to those with PTSD symptomtotology. This study has implications for not only adjustment to life post-deployment at the individual level but also operational readiness. Published by Elsevier Ltd. C1 [Kelley, Amanda M.; Athy, Jeremy R.; Cho, Timothy H.; Erickson, Bradley; King, Melody; Cruz, Pedro] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Kelley, AM (reprint author), USA, Aeromed Res Lab, Bldg 6901,Farrel Rd,POB 620577, Ft Rucker, AL 36362 USA. EM amanda.m.kelley@us.army.mil FU Medical Research and Material Command [633002.800C5, 622787.869P1] FX This project was funded by the Medical Research and Material Command under program element numbers 633002.800C5 and 622787.869P1. The funding source had no further role in study and statistical design, data collection, analysis, interpretation of findings, or writing of the report. NR 36 TC 17 Z9 17 U1 1 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3956 J9 J PSYCHIATR RES JI J. Psychiatr. Res. PD MAY PY 2012 VL 46 IS 5 BP 582 EP 589 DI 10.1016/j.jpsychires.2012.01.017 PG 8 WC Psychiatry SC Psychiatry GA 939VF UT WOS:000303846500003 PM 22305118 ER PT J AU Pavletic, AJ Hnatiuk, O AF Pavletic, Adriana J. Hnatiuk, Oleh TI Puzzling Dyspnea Caused by Respiratory Muscle Weakness SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE ALS (Amyotrophic Lateral Sclerosis); Dyspnea; Neuromuscular Disorders; Respiratory Muscles AB Dyspnea is common in advanced stages of neuromuscular disorders, but it is infrequently the presenting symptom. However, dyspnea is a frequent complaint in a primary care setting but is rarely caused by a respiratory muscle weakness. Consequently, the diagnosis of respiratory muscle weakness often is delayed. First symptoms may occur when respiratory muscles are under increased load, such as when standing in the water higher than the chest, swimming, or in the supine position. We describe a patient in whom dyspnea was the first symptom of amyotrophic lateral sclerosis to remind clinicians of clinical features of respiratory muscle weakness and to help avoid the delay in diagnosis. (J Am Board Fam Med 2012;25:396-397.) C1 [Pavletic, Adriana J.] NIMH, Off Clin Director, Bethesda, MD 20892 USA. [Hnatiuk, Oleh] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Pavletic, AJ (reprint author), NIMH, Off Clin Director, 10 Ctr Dr, Bethesda, MD 20892 USA. EM pavletia@mail.nih.gov FU National Institutes of Health FX This work was supported by the Intramural Research Program of the National Institutes of Health. NR 5 TC 2 Z9 2 U1 0 U2 1 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD MAY-JUN PY 2012 VL 25 IS 3 BP 396 EP 397 DI 10.3122/jabfm.2012.03.110220 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 939KY UT WOS:000303810600020 PM 22570404 ER PT J AU Wright, KM Cabrera, OA Eckford, RD Adler, AB Bliese, PD AF Wright, Kathleen M. Cabrera, Oscar A. Eckford, Rachel D. Adler, Amy B. Bliese, Paul D. TI The Impact of Predeployment Functional Impairment on Mental Health After Combat SO PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY LA English DT Article DE functional impairment; combat trauma; PTSD risk factors; postcombat adjustment ID POSTTRAUMATIC-STRESS-DISORDER; PRIMARY-CARE; VIETNAM VETERANS; TRAUMATIC EVENTS; IRAQ; DISABILITY; WAR; AFGHANISTAN; CONSISTENCY; POPULATION AB Impaired functioning in the aftermath of a combat deployment is well-established. What is less clear, however, is the role of impaired functioning prior to deployment in predicting mental health adjustment following a return home. In this study, a longitudinal design was used to assess PTSD and depression symptoms, anger problems, and impaired functioning in a sample of 522 U. S. Army soldiers, two months prior to a 12-month deployment to Iraq and again three months following their return home. The study had two objectives: To determine whether predeployment functional impairment predicted postdeployment psychological adjustment level (in terms of PTSD and depression symptoms, anger problems); and to assess whether predeployment functional impairment interacted with combat exposure such that greater impairment and higher exposure were associated with poorer postdeployment psychological outcomes. A significant interaction effect between predeployment functional impairment and combat exposure in the prediction of PTSD symptoms was found using mixed-effects modeling, suggesting that service members who are exposed to high levels of combat are at greater risk for PTSD symptoms if they deployed with preexisting problems in functioning. Significant independent effects were found in models predicting depression symptoms, anger problems, and postdeployment functional impairment. Results have implications for the health of service members participating in multiple combat deployments who have limited opportunity to recover between deployments. C1 [Wright, Kathleen M.; Eckford, Rachel D.; Adler, Amy B.] Walter Reed Army Inst Res, USA, Med Res Unit Europe, Heidelberg, Germany. [Cabrera, Oscar A.] USA, Mil Operat Med Res Program, Med Res & Mat Command, Ft Detrick, MD USA. [Bliese, Paul D.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Wright, KM (reprint author), USA, Med Res Unit, CMR 442 Box 94, APO, AE 09042 USA. EM kathleen.wright@us.army.mil NR 51 TC 8 Z9 8 U1 1 U2 9 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 1942-9681 EI 1942-969X J9 PSYCHOL TRAUMA-US JI Psychol. Trauma PD MAY PY 2012 VL 4 IS 3 BP 260 EP 269 DI 10.1037/a0024373 PG 10 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 941JI UT WOS:000303959100003 ER PT J AU Hosoda, T Wang, D Kipshidze, G Sarney, WL Shterengas, L Belenky, G AF Hosoda, T. Wang, D. Kipshidze, G. Sarney, W. L. Shterengas, L. Belenky, G. TI 3 mu m diode lasers grown on (Al)GaInSb compositionally graded metamorphic buffer layers SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article ID QUANTUM-WELL LASERS; TEMPERATURE OPERATION; WAVE; SEMICONDUCTORS; DISLOCATIONS; PARAMETERS; POWER AB Diode lasers operating at 3 mu m in continuous wave mode at room temperature were fabricated using metamorphic molecular beam epitaxy. The laser heterostructures have a lattice constant 1.3-1.6% bigger than that of the GaSb substrates. The mismatch between the epi-structure and the substrate lattice constants was accommodated by a network of misfit dislocations confined within linearly compositionally graded buffer layers. Two types of the buffers were tested-GaInSb and AlGaInSb. The laser heterostructures with Al-containing buffer layers demonstrated better surface morphology and produced devices with lower threshold and higher efficiency. At the same time the use of Al-containing buffers caused an excessive voltage drop across the laser heterostructure. Thus, a maximum continuous wave output power of 200 mW was obtained from lasers grown on GaInSb buffers, while only 170 mW was obtained from those grown on AlGaInSb buffers. C1 [Hosoda, T.; Wang, D.; Kipshidze, G.; Shterengas, L.; Belenky, G.] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. [Sarney, W. L.] USA, Res Lab, Adelphi, MD 20783 USA. RP Shterengas, L (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA. EM leon@ece.sunysb.edu FU US National Science Foundation [DMR0710154]; US Army Research Office [W911NF11-1-0109] FX This work was supported by the US National Science Foundation under grant DMR0710154 and US Army Research Office under grant W911NF11-1-0109. NR 20 TC 8 Z9 8 U1 1 U2 16 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAY PY 2012 VL 27 IS 5 AR 055011 DI 10.1088/0268-1242/27/5/055011 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA 938UP UT WOS:000303758900012 ER PT J AU Boninger, ML Brienza, D Charlifue, S Chen, YY Curley, KC Graves, DE Groah, S Heinemann, AW Hudson, LM Jackson, AB Johnson, KL Kalpakjian, CZ Kusiak, A Larson, KE Agustin, TS Sherwood, AM Shinowara, N Stripling, T Tate, D AF Boninger, M. L. Brienza, D. Charlifue, S. Chen, Y-Y Curley, K. C. Graves, D. E. Groah, S. Heinemann, A. W. Hudson, L. M. Jackson, A. B. Johnson, K. L. Kalpakjian, C. Z. Kusiak, A. Larson, K. E. Agustin, T. S. Sherwood, A. M. Shinowara, N. Stripling, T. Tate, D. TI State of the Science Conference in Spinal Cord Injury Rehabilitation 2011: introduction SO SPINAL CORD LA English DT Editorial Material DE spinal cord injury; rehabilitation; research funding ID MODEL SYSTEMS C1 [Heinemann, A. W.] Northwestern Univ, Dept Phys Med & Rehabil, Ctr Rehabil Outcomes Res, Feinberg Sch Med,Rehabil Inst Chicago, Chicago, IL 60611 USA. [Boninger, M. L.] Univ Pittsburgh, Sch Med, Dept Phys Med & Rehabil, Pittsburgh, PA USA. [Boninger, M. L.] VA Pittsburgh Healthcare Syst, Human Engn Res Labs, Pittsburgh, PA USA. [Brienza, D.] Univ Pittsburgh, Dept Rehabil Sci & Technol, Rehabil Engn Res Ctr Spinal Cord Injury, Pittsburgh, PA USA. [Charlifue, S.] Craig Hosp, SCI Model Syst, Englewood, CO USA. [Chen, Y-Y] Univ Alabama Birmingham, Dept Phys Med & Rehabil, Birmingham, AL USA. [Curley, K. C.] USA, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, ATTN MCMR RTC, Ft Detrick, MD USA. [Curley, K. C.] Ctr Disaster & Humanitarian Assistance Med, Dept Sci & Med, Bethesda, MD USA. [Curley, K. C.] Uniformed Serv Univ Hlth Sci, Dept Biomed Informat, Bethesda, MD 20814 USA. [Curley, K. C.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Graves, D. E.] Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA. [Groah, S.] Natl Rehabil Hosp, Washington, DC USA. [Hudson, L. M.] Shepherd Ctr, SE Reg SCI Model Syst, Atlanta, GA USA. [Jackson, A. B.] Univ Alabama Birmingham, Sch Med, Dept PM&R, Birmingham, AL USA. [Johnson, K. L.] Univ Washington, Sch Med, Dept Rehabil Med, Div Rehabil Counseling, Seattle, WA 98195 USA. [Kalpakjian, C. Z.] Univ Michigan, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. [Kusiak, A.] US EPA, Off Res & Dev, Dept Vet Affairs, Washington, DC 20460 USA. [Larson, K. E.] NSCIA, Elmhurst, NY USA. [Agustin, T. S.] Natl Inst Disabil & Rehabil Res, OSERS US Dept Educ, Washington, DC USA. [Sherwood, A. M.] Baylor Coll Med, Washington, DC USA. [Shinowara, N.] NICHD, Natl Ctr Med Rehabil Res, NIH, Bethesda, MD USA. [Stripling, T.] Larkview Court, Fairfax Stn, VA USA. [Tate, D.] Univ Michigan, Michigan Burlington Off Ctr, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA. RP Heinemann, AW (reprint author), Northwestern Univ, Dept Phys Med & Rehabil, Ctr Rehabil Outcomes Res, Feinberg Sch Med,Rehabil Inst Chicago, 345 E Super St, Chicago, IL 60611 USA. EM a-heinemann@northwestern.edu RI Heinemann, Allen /K-6283-2012; OI Heinemann, Allen /0000-0003-2782-7326; Sherwood, Arthur/0000-0002-0110-4317; Boninger, Michael/0000-0001-6966-919X FU NCATS NIH HHS [UL1 TR000005]; NCRR NIH HHS [UL1 RR024153] NR 2 TC 2 Z9 2 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1362-4393 J9 SPINAL CORD JI Spinal Cord PD MAY PY 2012 VL 50 IS 5 SI SI BP 342 EP 343 DI 10.1038/sc.2012.13 PG 2 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 938ZF UT WOS:000303771700002 PM 22450887 ER PT J AU Gilstad, C Roschewski, M Wells, J Delmas, A Lackey, J Uribe, P Popa, C Jardeleza, T Roop, S AF Gilstad, Colleen Roschewski, Mark Wells, Justin Delmas, Andrew Lackey, Jeffrey Uribe, Paul Popa, Christian Jardeleza, Timothy Roop, Stuart TI Fatal transfusion-associated graft-versus-host disease with concomitant immune hemolysis in a group A combat trauma patient resuscitated with group O fresh whole blood SO TRANSFUSION LA English DT Article ID TRANSPLANTATION; CELLS AB Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare but well-established fatal complication of blood transfusion. It can occur in immunocompetent patients when they receive transfusions from human leukocyte antigen-haploidentical donors who have lymphocytes with antigens that are not recognized as foreign by the host, but that recognize the host's tissues as foreign. It is generally viewed as a T-cell-mediated process. Graft-induced immune hemolysis or passenger lymphocyte syndrome is a well-described complication of marrow or solid organ transplantation in which immune competent donor B cells produce alloantibodies to recipient red blood cell (RBC) antigens and cause hemolysis of the recipient's RBCs. It is generally considered as a separate process from GVHD, although it could be considered a type of GVHD. Despite the theoretical possibility of both a B-cell and T-cell component to TA-GVHD, detection of a humoral antibody in cases of acute TA-GVHD has not been described. We describe the clinical course and laboratory evaluation of a group A combat trauma patient who was acutely resuscitated with group O fresh whole blood and RBCs and group AB fresh-frozen plasma who experienced the onset of the clinical symptoms of TA-GVHD as well as the onset of hemolysis due to donor-derived anti-A in his plasma 11 days after transfusion. C1 [Gilstad, Colleen] Natl Naval Med Ctr, Dept Lab Med, Bethesda, MD 20889 USA. Walter Reed Army Med Ctr, Dept Hematol Oncol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Crit Care Med, Washington, DC 20307 USA. Off Armed Forces Med Examiner, Rockville, MD USA. RP Gilstad, C (reprint author), Natl Naval Med Ctr, Dept Lab Med, Bethesda, MD 20889 USA. EM colleen.gilstad@med.navy.mil OI Roschewski, Mark/0000-0003-0278-2635 NR 11 TC 11 Z9 11 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAY PY 2012 VL 52 IS 5 BP 930 EP 935 DI 10.1111/j.1537-2995.2011.03365.x PG 6 WC Hematology SC Hematology GA 940GB UT WOS:000303876900004 PM 21981662 ER PT J AU Spinella, PC Dunne, J Beilman, GJ O'Connell, RJ Borgman, MA Cap, AP Rentas, F AF Spinella, Philip C. Dunne, James Beilman, Greg J. O'Connell, Robert J. Borgman, Matthew A. Cap, Andrew P. Rentas, Francisco TI Constant challenges and evolution of US military transfusion medicine and blood operations in combat SO TRANSFUSION LA English DT Review ID FRESH WHOLE-BLOOD; DAMAGE CONTROL RESUSCITATION; 753 CONSECUTIVE DEATHS; LEVEL TRAUMA CENTER; MASSIVE TRANSFUSION; EARLY COAGULOPATHY; FROZEN-BLOOD; APHERESIS PLATELETS; INJURY PREVENTION; IRAQI FREEDOM AB BACKGROUND: Blood operations are constrained by many limitations in combat settings. As a result there are many challenges that require innovative solutions. STUDY DESIGN AND METHODS: This is a descriptive overview of blood product usage and transfusion medicine adaptations that have been employed by the US military to support combat operations in Iraq and Afghanistan between November 2001 and December 2010. RESULTS: Transfusion medicine challenges have included the need for rapid transport of large quantities of blood products from the United States to Iraq and Afghanistan, risks and appropriate countermeasures associated with blood products collected in the theater of operations, availability of fresh-frozen plasma at forward surgical facilities, need for platelets (PLTs) in combat, and the need to support constant and evolving changes in transfusion and resuscitation protocols. A decrease in the storage age of red blood cells (RBCs) transfused to combat casualties has been achieved. There has been an increase in the ratio of plasma and PLTs to RBCs transfused, increased availability of plasma and apheresis PLTs to facilitate this approach, and a continuous effort to improve the safety of using fresh whole blood and apheresis PLTs collected in combat. A number of clinical practice guidelines are in place to address these processes. CONCLUSION: This multidisciplinary approach has successfully addressed many complicated and challenging issues regarding blood operations and transfusion practices for combat casualties. C1 Washington Univ, Dept Pediat, St Louis, MO 63110 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Blood Syst Res Inst, San Francisco, CA USA. Bethesda Naval Med Ctr, Dept Surg, Bethesda, MD USA. Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Brooke Army Med Ctr, San Antonio, TX USA. Armed Serv Blood Program Off, Falls Church, VA USA. RP Spinella, PC (reprint author), Washington Univ, St Louis Childrens Hosp, 660 S Euclid, St Louis, MO 63110 USA. EM spinella_p@kids.wustl.edu RI Borgman, Matthew/L-9477-2015; OI Borgman, Matthew/0000-0002-2008-7380; Beilman, Gregory/0000-0001-5036-3027 NR 32 TC 29 Z9 30 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD MAY PY 2012 VL 52 IS 5 BP 1146 EP 1153 DI 10.1111/j.1537-2995.2012.03594.x PG 8 WC Hematology SC Hematology GA 940GB UT WOS:000303876900029 PM 22575063 ER PT J AU Atesok, KI Hurwitz, SR Egol, KA Ahn, J Owens, BD Crosby, LA Pellegrini, VD AF Atesok, Kivanc I. Hurwitz, Shepard R. Egol, Kenneth A. Ahn, Jaimo Owens, Brett D. Crosby, Lynn A. Pellegrini, Vincent D., Jr. TI Perspective: Integrating Research Into Surgical Residency Education: Lessons Learned From Orthopaedic Surgery SO ACADEMIC MEDICINE LA English DT Article ID CLINICIAN-SCIENTIST; CARTILAGE REPAIR; FACULTY; FUTURE; ATTITUDES; SCIENCE; PRODUCTIVITY; MENTORSHIP; EXPERIENCE; MEDICINE AB Orthopaedic research has advanced tremendously in parallel with accelerated progress in medical science. Possession of a fundamental understanding of basic and clinical science has become more essential than previously for orthopaedic surgeons to be able to translate advances in research into clinical practice. The number of medical graduates with prior education in scientific research who choose to pursue careers in orthopaedic surgery is small. Therefore, it is important that a core of research education be included during residency training to ensure the continued advancement of the clinical practice of orthopaedics. The authors examine some of the challenges to a comprehensive research experience during residency, including deficient priority, inadequate institutional infrastructure, financial strain on residency budgets, restricted time, and an insufficient number of mentors to encourage and guide residents to become clinician-scientists. They also present some strategies to overcome these challenges, including development and expansion of residency programs with clinician-scientist pathways, promotion of financial sources, and enhancement of opportunities for residents to interact with mentors who can serve as role models. Successful integration of research education into residency programs will stimulate future orthopaedic surgeons to develop the critical skills to lead musculoskeletal research, comprehend related discoveries, and translate them into patient care. Lessons learned from incorporating research training within orthopaedic residency programs will have broad application across medical specialties-in both primary and subspecialty patient care. C1 [Pellegrini, Vincent D., Jr.] Univ Maryland, Sch Med, Dept Orthopaed, Baltimore, MD 21201 USA. [Atesok, Kivanc I.] Univ Toronto, Inst Med Sci, Sci Program, Toronto, ON M5S 1A1, Canada. [Hurwitz, Shepard R.] Univ N Carolina, Dept Orthopaed Surg, Chapel Hill, NC USA. [Egol, Kenneth A.] NYU Hosp Joint Dis, Dept Orthopaed Surg, New York, NY USA. [Ahn, Jaimo] Univ Penn, Dept Orthopaed Surg, Philadelphia, PA 19104 USA. [Owens, Brett D.] Keller Army Hosp, Orthopaed Surg Serv, West Point, NY USA. [Crosby, Lynn A.] Med Coll Georgia, Shoulder Div, Dept Orthopaed Surg, Augusta, GA 30912 USA. RP Pellegrini, VD (reprint author), Univ Maryland, Sch Med, Dept Orthopaed, 22 S Greene St,Suite S 11 B, Baltimore, MD 21201 USA. EM vpellegrini@umoa.umm.edu NR 43 TC 9 Z9 9 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-2446 EI 1938-808X J9 ACAD MED JI Acad. Med. PD MAY PY 2012 VL 87 IS 5 BP 592 EP 597 DI 10.1097/ACM.0b013e31824d2b57 PG 6 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 933TD UT WOS:000303384700019 PM 22450176 ER PT J AU Dixon, MD Johnson, WC Scott, ML Bowen, DE Rabbe, LA AF Dixon, Mark D. Johnson, W. Carter Scott, Michael L. Bowen, Daniel E. Rabbe, Lisa A. TI Dynamics of Plains Cottonwood (Populus deltoides) Forests and Historical Landscape Change along Unchannelized Segments of the Missouri River, USA SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE Riparian vegetation; Flow regulation; Dams; Channel change; Great Plains ID GREAT-PLAINS; NORTH-DAKOTA; RIPARIAN VEGETATION; FLOODPLAIN FORESTS; WISCONSIN RIVER; FLOW REGULATION; LAND-USE; DAMS; ESTABLISHMENT; RESTORATION AB Construction of six large dams and reservoirs on the Missouri River over the last 50-75 years has resulted in major landscape changes and alterations in flow patterns, with implications for riparian forests dominated by plains cottonwood (Populus deltoides). We quantified changes in land cover from 1892-1950s and the 1950s-2006 and the current extent and age structure of cottonwood forests on seven segments (two reservoir and five remnant floodplain) comprising 1127 km (53 %) of the unchannelized upper two-thirds of the Missouri River. Riparian forest area declined by 49 %; grassland 61 %; shrubland 52 %; and sandbar habitat 96 %; while agricultural cropland increased six-fold and river/reservoir surface area doubled from 1892 to 2006. Net rates of erosion and accretion declined between the 1892-1950s and 1950s-2006 periods. Accretion exceeded erosion on remnant floodplain segments, resulting in declines in active channel width, particularly in 1950s-2006. Across all study segments in 2006, most cottonwood stands (67 %) were > 50 years old, 22 % were 25-50 years old, and only 10 % were < 25 years old. Among stands < 50 years old, the higher proportion of 25-50 year old stands represents recruitment that accompanied initial post-dam channel narrowing; while declines in sandbar and shrubland area and the low proportion of stands < 25 years old suggest declines in geomorphic dynamism and limited recruitment under recent river management. Future conservation and restoration efforts should focus both on limiting further loss of remnant cottonwood stands and developing approaches to restore river dynamics and cottonwood recruitment processes. C1 [Dixon, Mark D.] Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA. [Johnson, W. Carter] S Dakota State Univ, Dept Nat Resource Management, Brookings, SD 57007 USA. [Bowen, Daniel E.] Benedictine Coll, Dept Biol, Atchison, KS 66002 USA. [Rabbe, Lisa A.] USA, Corps Engineers, Kansas City, MO 64106 USA. [Scott, Michael L.] US Geol Survey, Ft Sci Ctr, Ft Collins, CO 80526 USA. RP Dixon, MD (reprint author), Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA. EM Mark.Dixon@usd.edu RI Dixon, Mark/F-2641-2011 OI Dixon, Mark/0000-0002-0345-5655 FU U.S. Army Corps of Engineers, Kansas City District [W912DQ-07-C-0011]; University of South Dakota FX Funding was provided via contract # W912DQ-07-C-0011 from the U.S. Army Corps of Engineers, Kansas City District, with additional funding from the University of South Dakota. Caleb Caton, Rebekah Jessen, Adam Benson, Lisa Yager and other students at the University of South Dakota, and Elizabeth Reynolds, Dale Kohlmetz, Christopher Peltz, Michael Dodrill, Lindsey Washkoviak, Brittany Hummel, Keir Morse, and Tara Kline from the U. S. Geological Survey assisted with field sampling and mapping. Wes Christensen, Jesse Wolff, Heather Campbell and Drew Price from USD and Tammy Fancher and Hanna Moyer from USGS conducted much of the photo-interpretation and GIS work. Jon Kragt, USACE, Omaha District, provided georeferenced, digital copies of the 1892 Missouri River Commission maps. Tim Cowman, Missouri River Institute at USD, provided historical imagery and access to computer server space. Danielle Quist provided data on historical flows on imagery dates. Malia Volke of SDSU drafted our study area map. We thank representatives from numerous agencies and institutions, including the National Park Service, U.S. Fish and Wildlife Service, U. S. Army Corps of Engineers, Bureau of Land Management, Northern Prairies Land Trust, Yankton Sioux and Lower Brule Sioux Tribes, and South Dakota Department of Game, Fish, and Parks, for providing access to field sites. Finally, we thank the numerous private landowners who graciously provided access to their land. NR 69 TC 19 Z9 20 U1 3 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD MAY PY 2012 VL 49 IS 5 BP 990 EP 1008 DI 10.1007/s00267-012-9842-5 PG 19 WC Environmental Sciences SC Environmental Sciences & Ecology GA 934WO UT WOS:000303477700006 PM 22476667 ER PT J AU Holmquist, TJ Randow, CL AF Holmquist, T. J. Randow, C. L. TI Modeling the ballistic response of the 14.5 mm BS41 projectile SO EUROPEAN PHYSICAL JOURNAL-SPECIAL TOPICS LA English DT Article AB This article presents computed results of the U. S. Army Research Laboratory (ARL) 14.5 mm BS41 projectile impacting steel targets with varying impact conditions. The ARL BS41 is a complex projectile that includes a soft metal jacket, lead filler, inert powder and a high-strength tungsten carbide (WC) core. The WC core includes a nominal 6 wt% cobalt binder (WC-.06Co) producing significant ductility in compression but very little in tension. Recent 3D numerical algorithm advancements and a more accurate material model for WC produce computed results that are in good agreement with experimental results. The computed results demonstrate the ability to reproduce several key observations: the stripping of the steel jacket, lead filler and inert powder when impacting thin and thick steel targets; rigid body penetration of the WC core into thin and thick steel targets for normal impact; severe fracture and fragmentation of the core when impacting obliquely; and core fracture due to a yaw angle at impact. The computed results may also explain why the core fractures at low obliquities and shatters at high obliquities. Experimental data are also discussed and compared to the computed results. C1 [Holmquist, T. J.] SW Res Inst, Minneapolis, MN 55416 USA. [Randow, C. L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Holmquist, TJ (reprint author), SW Res Inst, Minneapolis, MN 55416 USA. EM tholmquist@swri.org FU U.S. Army Research Laboratory (ARL), Aberdeen Proving Ground, MD [W911QX-10-C-0040] FX This work was performed for the U.S. Army Research Laboratory (ARL), Aberdeen Proving Ground, MD under contract No. W911QX-10-C-0040. The authors would like to thank M. Burkins (ARL) for his helpful discussions and for providing specific test data, to L. Magness (ARL) for providing his insights, and to E. Horwath (ARL) for his contributions to this work. The authors would like to especially thank G. Johnson, S. Beissel, C. Gerlach and R. Stryk (SwRI) for the numerous contributions regarding algorithm development and enhancements in EPIC 2010. NR 16 TC 4 Z9 4 U1 1 U2 9 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1951-6355 J9 EUR PHYS J-SPEC TOP JI Eur. Phys. J.-Spec. Top. PD MAY PY 2012 VL 206 IS 1 BP 129 EP 137 DI 10.1140/epjst/e2012-01594-2 PG 9 WC Physics, Multidisciplinary SC Physics GA 934WP UT WOS:000303477800015 ER PT J AU Cameron, KL Marshall, SW Sturdivant, RX Lincoln, AE AF Cameron, Kenneth L. Marshall, Stephen W. Sturdivant, Rodney X. Lincoln, Andrew E. TI Trends in the Incidence of Physician-Diagnosed Mild Traumatic Brain Injury among Active Duty U.S. Military Personnel between 1997 and 2007 SO JOURNAL OF NEUROTRAUMA LA English DT Article DE epidemiology; mild traumatic brain injury; military; trends ID POSTTRAUMATIC-STRESS-DISORDER; SERVICE MEMBERS; MEDICAL SURVEILLANCE; CONCUSSION; SPORTS; IRAQ; COMBAT; RECOMMENDATIONS; EPIDEMIOLOGY; DISLOCATION AB Mild traumatic brain injury (mTBI) has been described as the most common form of traumatic brain injury within military populations; however, few epidemiologic studies have examined incidence rates for mTBI in this population. The objective of this study was to examine trends in the incidence of mTBI among active-duty U. S. service members between 1997 and 2007. Specifically, we were interested in evaluating trends in the incidence rates in relation to the initiation of combat operations in Iraq and Afghanistan. A retrospective cohort study was conducted utilizing data extracted from the Defense Medical Surveillance System to identify all incident cases of mTBI within the study population. The primary outcome of interest was the incidence rate of mTBI per 1000 person-years. Multivariable Poisson regression was used to analyze the data. There were 98,012 mTBI cases and 14,956,955 person-years of follow-up, for an overall incidence rate of 6.55 (95% CI 6.51,6.59) per 1000 person-years. There was a steady increase in the mTBI rate over time. The average change in the mTBI rate was 8.5% (95% CI 8.2%, 8.8%) per year; however, the rate rose dramatically in the last 2 years of the study period. Overall, for 2006-2007 versus 1997-2005, the rate ratio was 1.61 (95% CI 1.58,1.65). The greatest increase in the rate of mTBI was observed among those serving in Iraq, who experienced a 38.4% (95% CI 35.4%, 41.1%) annual increase in new cases. The observed increase in the incidence of mTBI in this population has significant policy implications in terms of allocating appropriate health care resources. C1 [Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. [Sturdivant, Rodney X.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Marshall, Stephen W.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA. [Lincoln, Andrew E.] Union Mem Hosp, MedStar Hlth Res Inst, Baltimore, MD USA. RP Cameron, KL (reprint author), US Mil Acad, Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM kenneth.cameron@amedd.army.mil OI Marshall, Stephen/0000-0002-2664-9233; Cameron, Kenneth/0000-0002-6276-4482 FU Congressionally Directed Medical Research Program's Post-Traumatic Stress Disorder and Traumatic Brain Injury Research Program [W81XWH-08-2-0152] FX The views and opinions expressed are those of the authors and do not represent the official policy of the U.S. Army, Department of Defense, or the U. S. government. We would like to thank Dr. Angie Eick-Cost and her staff from the Armed Forces Health Surveillance Center for assisting our research team with data acquisition. We would also like to acknowledge the U.S. service members on active duty during the study period between 1997 and 2007 for their selfless commitment to serve our nation. Finally, we would like to recognize the active-duty and civilian providers and support staff that coordinated and delivered the medical care for this cohort throughout the military health system. This project was supported by the Congressionally Directed Medical Research Program's Post-Traumatic Stress Disorder and Traumatic Brain Injury Research Program Award no. W81XWH-08-2-0152. NR 39 TC 15 Z9 15 U1 3 U2 6 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD MAY PY 2012 VL 29 IS 7 BP 1313 EP 1321 DI 10.1089/neu.2011.2168 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 933TC UT WOS:000303384600004 PM 22332633 ER PT J AU Howell, DL O'Dorisio, MS AF Howell, Della L. O'Dorisio, M. Sue TI Management of Neuroendocrine Tumors in Children, Adolescents, and Young Adults SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE management of neuroendocrine tumors in children; adolescents; young adults ID BRONCHIAL CARCINOID-TUMORS; RECEPTOR RADIONUCLIDE THERAPY; ENDOCRINE TUMORS; LIVER METASTASES; HEART-DISEASE; EXPERIENCE; APPENDIX; CHEMOEMBOLIZATION; CHILDHOOD; ANALOGS AB Neuroendocrine tumors, often referred to as carcinoid tumors, are relatively rare within the pediatric and young adult populations. However, when they do occur, the more aggressive tumors can be associated with significant morbidity and even mortality in this younger age group. This article reviews the history of pediatric neuroendocrine tumors, typical clinical presentation, appropriate diagnostic studies, staging, and treatment of this unusual cancer. C1 [Howell, Della L.] Univ Texas Hlth Sci Ctr San Antonio, Brooke Army Med Ctr, San Antonio, TX 78234 USA. [O'Dorisio, M. Sue] Univ Iowa, Childrens Hosp, Iowa City, IA USA. RP Howell, DL (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Brooke Army Med Ctr, San Antonio, TX 78234 USA. EM della.howell@amedd.army.mil FU NCI NIH HHS [R01 CA167632] NR 45 TC 8 Z9 8 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1077-4114 J9 J PEDIAT HEMATOL ONC JI J. Pediatr. Hematol. Oncol. PD MAY PY 2012 VL 34 SU 2 BP S64 EP S68 PG 5 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 939BR UT WOS:000303782300006 PM 22525409 ER PT J AU Guthrie, RJ Grindstaff, TL Croy, T Ingersoll, CD Saliba, SA AF Guthrie, Rebecca J. Grindstaff, Terry L. Croy, Theodore Ingersoll, Christopher D. Saliba, Susan A. TI The Effect of Traditional Bridging or Suspension-Exercise Bridging on Lateral Abdominal Thickness in Individuals With Low Back Pain SO JOURNAL OF SPORT REHABILITATION LA English DT Article DE lumbar stabilization; sonography; therapeutic exercise ID RANDOMIZED CONTROLLED-TRIAL; ANTERIOR CRUCIATE LIGAMENT; PELVIC GIRDLE PAIN; TRANSVERSUS ABDOMINIS; MUSCLE THICKNESS; CLASSIFICATION APPROACH; STABILIZATION EXERCISE; CONSERVATIVE TREATMENT; SPINAL MANIPULATION; PRIMARY-CARE AB Context: Individuals with low back pain (LBP) are thought to benefit from interventions that improve motor control of the lumbopelvic region. It is unknown if therapeutic exercise can acutely facilitate activation of lateral abdominal musculature. Objective: To investigate the ability of 2 types of bridging-exercise progressions to facilitate lateral abdominal muscles during an abdominal drawing-in maneuver (ADM) in individuals with LBP. Design: Randomized control trial. Setting: University research laboratory. Participants: 51 adults (mean +/- SD age 23.1 +/- 6.0 y, height 173.6 +/- 10.5 cm, mass 74.7 +/- 14.5 kg, and 64.7% female) with LBP. All participants met 3 of 4 criteria for stabilization-classification LBP or at least 6 best-fit criteria for stabilization classification. Interventions: Participants were randomly assigned to either traditional-bridge progression or suspension-exercise-bridge progression, each with 4 levels of progressive difficulty. They performed 5 repetitions at each level and were progressed based on specific criteria. Main Outcome Measures: Muscle thickness of the external oblique (EO), internal oblique (IO), and transversus abdominis (TrA) was measured during an ADIM using ultrasound imaging preintervention and postintervention. A contraction ratio (contracted thickness:resting thickness) of the EO, IO, and TrA was used to quantify changes in muscle thickness. Results: There was not a significant increase in EO (F-1,F-47 = 0.44, P = .51) or IO (F-1,F-47 = .30, P = .59) contraction ratios after the exercise progression. There was a significant (F-1,F-47 = 4.05, P = .05) group-by-time interaction wherein the traditional-bridge progression (pre = 1.55 +/- 0.22; post = 1.65 +/- 0.21) resulted in greater (P = .03) TrA contraction ratio after exercise than the suspension-exercise-bridge progression (pre = 1.61 +/- 0.31; post = 1.58 +/- 0.28). Conclusion: A single exercise progression did not acutely improve muscle thickness of the EO and IO. The magnitude of change in TrA muscle thickness after the traditional-bridging progression was less than the minimal detectable change, thus not clinically significant. C1 [Guthrie, Rebecca J.] Emory Sports Med Ctr, Dept Orthopaed, Atlanta, GA 30329 USA. [Grindstaff, Terry L.] Creighton Univ, Dept Phys Therapy, Omaha, NE 68178 USA. [Croy, Theodore] US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Ingersoll, Christopher D.] Cent Michigan Univ, Off Dean, Mt Pleasant, MI 48859 USA. [Saliba, Susan A.] Univ Virginia, Dept Human Serv, Charlottesville, VA USA. RP Guthrie, RJ (reprint author), Emory Sports Med Ctr, Dept Orthopaed, Atlanta, GA 30329 USA. RI Ingersoll, Christopher/H-6474-2015; OI Ingersoll, Christopher/0000-0001-9157-6846; Saliba, Susan/0000-0001-7179-8310 NR 45 TC 5 Z9 5 U1 0 U2 18 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1056-6716 J9 J SPORT REHABIL JI J. Sport Rehabil. PD MAY PY 2012 VL 21 IS 2 BP 151 EP 160 PG 10 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 936YU UT WOS:000303627000009 PM 22100462 ER PT J AU Hartzell, JD Gleeson, T Scoville, S Massung, RF Wortmann, G Martin, GJ AF Hartzell, Joshua D. Gleeson, Todd Scoville, Stephanie Massung, Robert F. Wortmann, Glenn Martin, Gregory J. TI Practice Guidelines for the Diagnosis and Management of Patients With Q Fever by the Armed Forces Infectious Diseases Society SO MILITARY MEDICINE LA English DT Article ID COXIELLA-BURNETII; FOLLOW-UP; US MILITARY; DOPPLER-ECHOCARDIOGRAPHY; BACTERICIDAL ACTIVITIES; VASCULAR COMPLICATIONS; CHAMBER QUANTIFICATION; STANDARDS COMMITTEE; OF-ECHOCARDIOGRAPHY; ENDOCARDITIS AB This issue in the series Current Topics in Military Tropical Medicine focuses on Q Fever. Q fever is a zoonotic infection caused by the bacterium Caxiella burnetii. Over 150 confirmed cases have occurred among U.S. military personnel deployed to Iraq since 2007. Acute Q fever is underdiagnosed because of a myriad of possible clinical presentations but typically presents as a flu-like illness. The most common chronic manifestation is endocarditis. Most providers are not familiar with the diagnosis, treatment, or appropriate follow-up of this disease. In order to facilitate the care of patients infected with C. burnetii, the Armed Forces Infectious Diseases Society convened a panel of experts in the field to develop practical guidelines for those caring for infected patients. The recommendations and rationale are reviewed in this article. C1 [Hartzell, Joshua D.; Wortmann, Glenn; Martin, Gregory J.] Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bethesda, MD 20889 USA. [Gleeson, Todd] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Scoville, Stephanie] USA, Publ Hlth Command, Army Inst Publ Hlth, Aberdeen Proving Ground, MD 21010 USA. [Massung, Robert F.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA. RP Hartzell, JD (reprint author), Walter Reed Natl Mil Med Ctr, Infect Dis Serv, Bldg 7,1st Floor,8901 Rockville Pike, Bethesda, MD 20889 USA. FU Navy Medicine Professional Development Center FX The series Current Topics in Military Tropical Medicine is an educational outreach program developed by the faculty of the U.S. Military Tropical Medicine program (MTM) and Military Medicine. MTM is a joint program which educates and trains military medical personnel in the practice of medicine in developing areas under the auspices of the Navy Medicine Professional Development Center. Questions and comments on this series should be directed to the series subeditor and Program Director, U.S. Military Tropical Medicine, Director.MTM@med.navy.mil. NR 70 TC 7 Z9 7 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2012 VL 177 IS 5 BP 484 EP 494 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 936XK UT WOS:000303623100004 PM 22645872 ER PT J AU Sipos, ML Foran, HM Crane, ML Wood, MD Wright, KM AF Sipos, Maurice L. Foran, Heather M. Crane, Maria L. Wood, Michael D. Wright, Kathleen M. TI Postdeployment Behavioral Health Screening: Face-to-Face Versus Virtual Behavioral Health Interviews SO MILITARY MEDICINE LA English DT Article ID ALCOHOL-CONSUMPTION; PRIMARY-CARE; SOLDIERS; COMBAT; IRAQ; CHECKLIST; DISORDER; BARRIERS; AUDIT; DUTY AB Virtual behavioral health (VBH) services are used frequently to address the high demand for behavioral health (BH) services in the military. Few studies have investigated the relationship between the use of VBH services and BH outcomes or preferences for the use of VBH technologies. In this article, we evaluated BH interviews conducted via video teleconferencing (VTC) or face-to-face in terms of BH symptoms, satisfaction rates, stigma, barriers to care, and preferences for future use of BH care. Soldiers (n = 307) from the headquarters element of an operational unit were surveyed 4 months following a 12-month deployment to Iraq. There were no significant differences in satisfaction rates based on interview modality, but significantly more soldiers preferred face-to-face interviews over VTC interviews in the future. Soldiers who preferred face-to-face interviews also reported higher levels of anxiety and depression symptoms than those who preferred VTC interviews. No significant age differences were found in terms of interview modality satisfaction or preference. Soldiers with greater deployment experience were more likely to report that they would not like using VTC if seeking BH care in the future than soldiers with less deployment experience. These findings highlight the importance of promoting choice in type of BH interview modality. C1 [Sipos, Maurice L.; Foran, Heather M.; Wood, Michael D.; Wright, Kathleen M.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, D-69126 Heidelberg, Germany. [Crane, Maria L.] Europe Reg Med Command, Behav Hlth Div, D-69126 Heidelberg, Germany. RP Sipos, ML (reprint author), Walter Reed Army Inst Res, US Army Med Res Unit Europe, Karlsruher Str 144, D-69126 Heidelberg, Germany. FU U.S. Army Medical Research and Materiel Command FX We thank Steven Terry, Rachel Eckford, Victor Martinez, Angela Salvi (Lead Research Associate), Amy Adler, and Lyndon Riviere. This study was funded by the Military Operational Research Program, U.S. Army Medical Research and Materiel Command. NR 19 TC 2 Z9 2 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2012 VL 177 IS 5 BP 525 EP 530 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 936XK UT WOS:000303623100010 PM 22645878 ER PT J AU Molloy, JM Feltwell, DN Scott, SJ Niebuhr, DW AF Molloy, Joseph M. Feltwell, David N. Scott, Shawn J. Niebuhr, David W. TI Physical Training Injuries and Interventions for Military Recruits SO MILITARY MEDICINE LA English DT Article ID EXERCISE-RELATED INJURIES; US ARMY RECRUITS; BODY-MASS INDEX; UNITED-STATES; MUSCULOSKELETAL INJURIES; ATHLETIC INJURIES; HEALTHY-ADULTS; RISK-FACTORS; FITNESS; FLEXIBILITY AB Low physical fitness levels are associated with increased musculoskeletal injury risk and attrition among military recruits. The authors review physical fitness trends, injury risk factors, and Department of the Army initiatives to address recruit fitness, injuries, and attrition. Initiatives include the Fitness Assessment Program, which reduced injury risk and attrition among low-fit trainees, and the Assessment of Recruit Motivation and Strength, which enabled the Army to enlist individuals exceeding body composition accession standards without increasing attrition. Physical Readiness Training (PRT) is the Army's primary initiative to address training-related injuries and attrition. PRT's inherent injury control and exercise progression components are designed to address low fitness levels across entry-level training. PRT has been shown to decrease injury rates, but low-fit recruits remain at increased risk regardless of program design. The authors recommend resuming pre-enlistment fitness screening and fitness programming before low-fit recruits begin entry-level training. The decision whether to screen for fitness before beginning entry-level training could be based upon the existing recruiting environment in terms of applicant supply and the demand for recruits. However. the Army should anticipate increased injury and attrition rates when discontinuing screening and/or fitness programming for low-fit recruits. C1 [Molloy, Joseph M.] Ft Sam Houston Primary Care Clin, Ft Sam Houston, TX 78234 USA. [Scott, Shawn J.] Tripler Army Med Ctr, ATTN Phys Therapy, Honolulu, HI 96859 USA. [Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. RP Molloy, JM (reprint author), Ft Sam Houston Primary Care Clin, 3100 Schofield Rd,Bldg 1179, Ft Sam Houston, TX 78234 USA. NR 48 TC 12 Z9 12 U1 0 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2012 VL 177 IS 5 BP 553 EP 558 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 936XK UT WOS:000303623100014 PM 22645882 ER PT J AU Newman, T Croy, T Hart, J Saliba, S AF Newman, Thomas Croy, Theodore Hart, Joseph Saliba, Susan TI The Effects of Prophylactic Ankle Bracing on Dynamic Reach Distance and Obstacle Course Performance in Military Cadets SO MILITARY MEDICINE LA English DT Article ID TRAINING-RELATED INJURIES; SUPPORT; INSTABILITY; PREVENTION; EFFICACY AB Ankle braces can protect the ankle joint from ligament sprains and fractures during high-risk military activities such as physical training and parachuting. Although braces are recommended for injury prevention purposes, the impact of braces on physical performance is unknown. This study evaluated lace-up ankle braces, worn inside the boots, across three conditions: no brace, unilateral brace, and bilateral brace on the dependent variables of dynamic lower extremity reach and obstacle course performance. Thirty-seven military cadets were tested over 3 days. Ankle bracing had a small effect upon anterior and composite lower extremity reach distances. Bracing had no effect upon obstacle course performance times. Inside-the-boot ankle bracing restricts lower extremity reaching and mildly impacts mobility, however, no restrictions were observed with running, climbing, jumping, or negotiating obstacles. Lace-up ankle braces can be used in conjunction with combat boots to protect the ankle during high-risk activities without having an impact upon tactical movements. C1 [Newman, Thomas] Univ Orthoped Ctr, State Coll, PA 16801 USA. [Croy, Theodore] Baylor Univ, USA, Doctoral Program Phys Therapy, Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. [Hart, Joseph; Saliba, Susan] Univ Virginia, Dept Human Serv Kinesiol, Charlottesville, VA 22904 USA. RP Newman, T (reprint author), Univ Orthoped Ctr, 101 Regent Court, State Coll, PA 16801 USA. OI Croy, Theodore/0000-0002-3053-8974; Saliba, Susan/0000-0001-7179-8310; Hart, Joe/0000-0002-0410-5112 FU Virginia Military Institute FX The authors would like to thank the following people for their support in the completion of this project: Lance Fujiwara, John Hoffman, Andrew Spadafora, Carolyn Dartt, and Colin Herb, Virginia Military Institute coaches Nachion Moore, Chris Skretkowicz, CPT Gregory S. Nickerson, and Marine Gunnery Sergeant Bradley S. Driver, NR 21 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2012 VL 177 IS 5 BP 567 EP 572 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 936XK UT WOS:000303623100016 PM 22645884 ER PT J AU Hakre, S Paris, RM Brian, JE Malia, J Sanders-Buell, EE Tovanabutra, S Sleigh, BC Cook, JE Michael, NL Scott, PT Deuter, DR Cersovsky, SB Peel, SA AF Hakre, Shilpa Paris, Robert M. Brian, Julie E. Malia, Jennifer Sanders-Buell, Eric E. Tovanabutra, Sodsai Sleigh, Bryan C. Cook, James E. Michael, Nelson L. Scott, Paul T. Deuter, Dan R. Cersovsky, Steven B. Peel, Sheila A. TI Enhanced U.S. Army HIV Diagnostic Algorithm Used to Diagnose Acute HIV Infection in a Deployed Soldier SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES; TRANSMISSION; SEROCONVERSION AB Antibody screening alone may fail to detect human immunodeficiency virus (HIV) in recently infected individuals. By U.S. Army regulation, HIV-infected soldiers are not permitted to deploy to areas of conflict, including Iraq and Afghanistan. We report here the first case of acute HIV infection (AHI) in a soldier in a combat area of operation detected by an enhanced U.S. Army HIV testing algorithm and discuss features of the tests which aided in clinical diagnosis. We tested the sample from the AHI case with a third generation HIV-1/HIV-2 plus O enzyme immunoassay, HIV-1 Western Blot, and a qualitative HIV-1 ribonucleic acid molecular diagnostic assay. Risk factors for HIV acquisition were elicited in an epidemiologic interview. Evaluation of the blood sample for AHI indicated an inconclusive serologic profile and a reactive HIV-1 ribonucleic acid result. The main risk factor for acquisition reported was unprotected sexual intercourse with casual strangers in the U.S. while on leave during deployment. The clinical diagnosis of AHI in a combat area of operation is important. Diagnosis of HIV is key to preventing adverse effects to the infected soldier from deployment stressors of deployment and further transmission via parenteral or sexual exposures. C1 [Hakre, Shilpa] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Paris, Robert M.] Walter Reed Natl Mil Med Ctr Bethesda, Infect Dis Serv Clin, Dept Med, Bethesda, MD 20810 USA. [Brian, Julie E.] 75th Battle Command Training Div, Ft Dix, NJ 08640 USA. [Malia, Jennifer; Peel, Sheila A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD 20850 USA. [Sanders-Buell, Eric E.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Rockville, MD 20910 USA. [Sleigh, Bryan C.] Royal Mil Acad Sandhurst, HQ Army Med Directorate, FASC, Sandhurst 09494, England. [Cook, James E.] Madigan Army Med Ctr, Dept Prevent Med, Tacoma, WA 98431 USA. [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. [Scott, Paul T.] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD 20817 USA. [Deuter, Dan R.] Med Command, Ft Sam Houston, TX 78234 USA. [Cersovsky, Steven B.] USA, Publ Hlth Command Epidemiol & Dis Surveillance, ATTN MCHB TS D, Aberdeen Proving Ground, MD 21010 USA. RP Hakre, S (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, 6720-A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. FU Defense Health Program 8; The Defense Health Program 8 funds for clinical diagnostics FX The Defense Health Program 8 funds for clinical diagnostics. NR 17 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2012 VL 177 IS 5 BP 609 EP 613 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 936XK UT WOS:000303623100023 PM 22645891 ER PT J AU Brady, TL Scholler, J Binder-Scholl, G Hwang, WT Plesa, G Hege, K Vogel, A Deeks, S Mitsuyasu, R Bernstein, WB Aronson, N Levine, BL Bushman, FD June, CH AF Brady, Troy L. Scholler, John Binder-Scholl, Gwendolyn Hwang, Wei-Ting Plesa, Gabriela Hege, Kristen Vogel, Ashley Deeks, Steven Mitsuyasu, Ronald Bernstein, Wendy B. Aronson, Naomi Levine, Bruce L. Bushman, Frederic D. June, Carl H. TI Integration Site Analysis Indicates Decade-Long Safety of Gammaretroviral-Modified Chimeric Antigen Receptor T-Cells SO MOLECULAR THERAPY LA English DT Meeting Abstract CT 15th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) CY MAY 16-19, 2012 CL Philadelphia, PA SP Amer Soc Gene & Cell Therapy (ASGCT) C1 [Brady, Troy L.; Scholler, John; Binder-Scholl, Gwendolyn; Hwang, Wei-Ting; Plesa, Gabriela; Vogel, Ashley; Levine, Bruce L.; Bushman, Frederic D.; June, Carl H.] Univ Penn, Philadelphia, PA 19104 USA. [Hege, Kristen] Celgene Corp, San Francisco, CA USA. [Deeks, Steven] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Mitsuyasu, Ronald] Univ Calif Los Angeles, Los Angeles, CA USA. [Bernstein, Wendy B.; Aronson, Naomi] Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1525-0016 J9 MOL THER JI Mol. Ther. PD MAY PY 2012 VL 20 SU 1 MA 553 BP S214 EP S214 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 934YU UT WOS:000303484600553 ER PT J AU Peddada, LY Mishra, S Garbuzenko, OB Minko, T Devore, DI Roth, CM AF Peddada, Lavanya Y. Mishra, Swati Garbuzenko, Olga B. Minko, Tamara Devore, David I. Roth, Charles M. TI Multifunctional Lipid-Polymer Nanoparticles for Enhanced Serum Stability and Intracellular Delivery of Oligonucleotides SO MOLECULAR THERAPY LA English DT Meeting Abstract CT 15th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) CY MAY 16-19, 2012 CL Philadelphia, PA SP Amer Soc Gene & Cell Therapy (ASGCT) C1 [Peddada, Lavanya Y.; Mishra, Swati; Roth, Charles M.] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ USA. [Garbuzenko, Olga B.; Minko, Tamara] Rutgers State Univ, Dept Pharmaceut, Piscataway, NJ USA. [Devore, David I.] USA, Inst Surg Res, Battlefield Hlth & Trauma Res Inst, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1525-0016 J9 MOL THER JI Mol. Ther. PD MAY PY 2012 VL 20 SU 1 MA 723 BP S279 EP S279 PG 1 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA 934YU UT WOS:000303484600718 ER PT J AU Zinnert, JC Nelson, JD Hoffman, AM AF Zinnert, Julie C. Nelson, Jean D. Hoffman, Ava M. TI Effects of salinity on physiological responses and the photochemical reflectance index in two co-occurring coastal shrubs SO PLANT AND SOIL LA English DT Article DE Chlorophyll fluorescence; Chlorophyll pigments; Gas exchange; Photosystem II photochemistry; PRI; Remote sensing; Salinity treatment ID LIGHT USE EFFICIENCY; LEAF GAS-EXCHANGE; CHLOROPHYLL FLUORESCENCE; PHILLYREA-LATIFOLIA; XANTHOPHYLL CYCLE; QUERCUS-ILEX; SALT STRESS; PHOTOSYNTHETIC EFFICIENCY; DEEPOXIDATION STATE; WATER-STRESS AB The photochemical reflectance index (PRI) is correlated to photosynthetic efficiency and has been successfully applied at multiple scales for remote estimation of physiological functioning. However, interpretation of the PRI signal can be confounded by many different variables including declines in photochemical pigments. Our study was aimed at investigating PRI in response to salinity stress, and evaluating physiological and pigment responses of two co-occurring shrubs, Baccharis halimifolia and Myrica cerifera in laboratory studies. Photosynthesis, water relations, chlorophyll fluorescence, hyperspectral reflectance and leaf pigment contents were measured following salinity treatment. Physiological measurements indicated that both species exhibit adaptations which protect PSII during periods of stress. Chlorophyll fluorescence parameters were affected in both species, but indicated that other photochemical reactions (e.g. photorespiration) were important for energy dissipation in absence of chlorophyll changes. After many days of reduced photosynthesis, photochemical changes were detectable using PRI indicating chronic stress. Variations in PRI were not related to changes in pigments but strongly related to tissue chlorides indicating salinity effects on the PRI signal. Thus, PRI is an indicator of salinity stress in these coastal species and may be as an early signal for increasing salt exposure associated with rising sea-level and climate change. C1 [Zinnert, Julie C.; Nelson, Jean D.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. [Zinnert, Julie C.; Nelson, Jean D.; Hoffman, Ava M.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. RP Zinnert, JC (reprint author), USA, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM jczinner@vcu.edu FU U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC); U.S. Army RDECOM ARL Army Research Office [W911NF-06-1-0074] FX The authors thank Donald R Young for thorough review and comments on an earlier draft of this manuscript. This research was supported by internal basic research program funds from the U.S. Army Corps of Engineers/Engineer Research and Development Center (ERDC) and (in part) by the U.S. Army RDECOM ARL Army Research Office under grant W911NF-06-1-0074. NR 47 TC 11 Z9 12 U1 3 U2 27 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0032-079X EI 1573-5036 J9 PLANT SOIL JI Plant Soil PD MAY PY 2012 VL 354 IS 1-2 BP 45 EP 55 DI 10.1007/s11104-011-0955-z PG 11 WC Agronomy; Plant Sciences; Soil Science SC Agriculture; Plant Sciences GA 933SY UT WOS:000303384200004 ER PT J AU Guaraldi, F Landek-Salgado, MA Hutfless, S Samoni, F Talor, MV Matos, PG Salvatori, R Rose, NR Caturegli, P AF Guaraldi, Federica Landek-Salgado, Melissa A. Hutfless, Susan Samoni, Francesca Talor, Monica V. Matos, Peter G. Salvatori, Roberto Rose, Noel R. Caturegli, Patrizio TI Pituitary Antibodies in Women with Hashimoto's Thyroiditis: Prevalence in Diagnostic and Prediagnostic Sera SO THYROID LA English DT Article ID ANTIPITUITARY ANTIBODIES; LYMPHOCYTIC HYPOPHYSITIS; AUTOIMMUNE-DISEASES; GRAVES-DISEASE; UNITED-STATES; EPIDEMIOLOGY AB Background: Pituitary antibodies have been reported with greater frequency in patients with Hashimoto's thyroiditis than in healthy controls, although there is significant variability in the strength of the association and the methodologies used. Methods: We designed a nested case-control study to characterize the prevalence of pituitary antibodies at the time of the clinical diagnosis of Hashimoto's thyroiditis, as well as at 2, 5, and 7 years before diagnosis. Active component female service member cases (n = 87) and matched female controls (n = 107) were selected using the Defense Medical Surveillance System database (DMSSD) between January 1998 and December 2007. Pituitary antibodies were measured by immunofluorescence using human pituitary glands collected at autopsy as the substrate. Results: At diagnosis, pituitary antibodies were present in 9% of cases with Hashimoto's (8 of 87) and 3% of controls (3 of 107). When the data were analyzed using a conditional logistic regression model, which takes into account the matching on age and work status, pituitary antibodies increased the odds of having Hashimoto's thyroiditis by sevenfold (95% confidence interval from 1.3 to 40.1, p = 0.028), after adjusting for components of the DMSSD-category-termed race and for thyroperoxidase antibodies. Before diagnosis, pituitary antibodies were positive in 3 of the 11 subjects (2 cases and 1 control) at the -2-year time point, and negative in all 11 subjects at the -5- and -7-year time points. Conclusions: In summary, using a nested case-control design, we confirm that pituitary antibodies are more common in Hashimoto's thyroiditis and suggest that they appear late during its natural history. C1 [Guaraldi, Federica; Landek-Salgado, Melissa A.; Samoni, Francesca; Talor, Monica V.; Rose, Noel R.; Caturegli, Patrizio] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. [Hutfless, Susan] Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA. [Salvatori, Roberto] Johns Hopkins Univ, Sch Med, Div Endocrinol, Baltimore, MD 21205 USA. [Rose, Noel R.; Caturegli, Patrizio] Johns Hopkins Univ, Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA. [Guaraldi, Federica] Univ Turin, Dept Internal Med, Div Endocrinol Diabetol & Metab, Turin, Italy. [Matos, Peter G.] USA, Joint Munit Command Surg, Joint Munit Command Headquarters AMSJM HRS, Rock Isl, IL USA. RP Caturegli, P (reprint author), Johns Hopkins Univ, Sch Med, Dept Pathol, Ross Bldg,Room 656,720 Rutland Ave, Baltimore, MD 21205 USA. EM pcat@jhmi.edu OI Landek-Salgado, Melissa/0000-0002-4707-2066; Hutfless, Susan/0000-0002-6311-2611 FU NIH [DK080351] FX The authors thank Dr. Angie Eick-Cost, Special Studies Lead at the Armed Forces Health Surveillance Center, and Mrs. Ashley Cardamone from the Department of Pathology, Johns Hopkins University, for their help with the study. This work was supported by NIH grant DK080351 to P.C. NR 27 TC 4 Z9 4 U1 0 U2 13 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1050-7256 EI 1557-9077 J9 THYROID JI Thyroid PD MAY PY 2012 VL 22 IS 5 BP 509 EP 515 DI 10.1089/thy.2011.0373 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 935UI UT WOS:000303546500010 PM 22468943 ER PT J AU Kumar, G Kumaran, D Ahmed, SA Swaminathan, S AF Kumar, Gyanendra Kumaran, Desigan Ahmed, S. Ashraf Swaminathan, Subramanyam TI Peptide inhibitors of botulinum neurotoxin serotype A: design, inhibition, cocrystal structures, structure-activity relationship and pharmacophore modeling SO ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY LA English DT Article DE botulinum neurotoxins; peptide inhibitors; structure-activity relationship; pharmacophore modeling ID SMALL-MOLECULE INHIBITORS; LIGHT-CHAIN; SUBSTRATE RECOGNITION; NEUROTRANSMITTER RELEASE; ZINC ENDOPEPTIDASE; SNAP-25 SUBSTRATE; CRYSTAL-STRUCTURE; NERVE-TERMINALS; MOTOR NERVES; BINDING AB Clostridium botulinum neurotoxins are classified as Category A bioterrorism agents by the Centers for Disease Control and similar to Prevention (CDC). The seven serotypes (AG) of the botulinum neurotoxin, the causative agent of the disease botulism, block neurotransmitter release by specifically cleaving one of the three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins and induce flaccid paralysis. Using a structure-based drug-design approach, a number of peptide inhibitors were designed and their inhibitory activity against botulinum serotype A (BoNT/A) protease was determined. The most potent peptide, RRGF, inhibited BoNT/A protease with an IC50 of 0.9 mu M and a Ki of 358 nM. High-resolution crystal structures of various peptide inhibitors in complex with the BoNT/A protease domain were also determined. Based on the inhibitory activities and the atomic interactions deduced from the cocrystal structures, the structureactivity relationship was analyzed and a pharmacophore model was developed. Unlike the currently available models, this pharmacophore model is based on a number of enzymeinhibitor peptide cocrystal structures and improved the existing models significantly, incorporating new features. C1 [Kumar, Gyanendra; Kumaran, Desigan; Swaminathan, Subramanyam] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. [Ahmed, S. Ashraf] USA, Dept Mol Biol, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Swaminathan, S (reprint author), Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. EM swami@bnl.gov RI Kumar, Gyanendra/B-1751-2009 OI Kumar, Gyanendra/0000-0001-7593-0737 FU DTRA under DOE [BO742081, DEAC02-98CH10886]; Brookhaven National Laboratory FX This research was supported by an award from DTRA BO742081 under DOE prime contract No. DEAC02-98CH10886 with Brookhaven National Laboratory. We thank PXRR at the NSLS (BNL) for data-collection facilities. NR 53 TC 12 Z9 12 U1 0 U2 8 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0907-4449 J9 ACTA CRYSTALLOGR D JI Acta Crystallogr. Sect. D-Biol. Crystallogr. PD MAY PY 2012 VL 68 BP 511 EP 520 DI 10.1107/S0907444912003551 PN 5 PG 10 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography SC Biochemistry & Molecular Biology; Biophysics; Crystallography GA 930SF UT WOS:000303159000003 PM 22525749 ER PT J AU Diebal, AR Gregory, R Alitz, C Gerber, JP AF Diebal, Angela R. Gregory, Robert Alitz, Curtis Gerber, J. Parry TI Forefoot Running Improves Pain and Disability Associated With Chronic Exertional Compartment Syndrome SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE chronic exertional compartment syndrome; anterior compartment syndrome; forefoot running; leg pain ID ANTERIOR COMPARTMENT; LOWER LEG; INTRACOMPARTMENTAL PRESSURES; SURGICAL-TREATMENT; STANCE PHASE; BAREFOOT; EXERCISE; MANAGEMENT; FASCIOTOMY; DIAGNOSIS AB Background: Anterior compartment pressures of the leg as well as kinematic and kinetic measures are significantly influenced by running technique. It is unknown whether adopting a forefoot strike technique will decrease the pain and disability associated with chronic exertional compartment syndrome (CECS) in hindfoot strike runners. Hypothesis: For people who have CECS, adopting a forefoot strike running technique will lead to decreased pain and disability associated with this condition. Study Design: Case series; Level of evidence, 4. Methods: Ten patients with CECS indicated for surgical release were prospectively enrolled. Resting and postrunning compartment pressures, kinematic and kinetic measurements, and self-report questionnaires were taken for all patients at baseline and after 6 weeks of a forefoot strike running intervention. Run distance and reported pain levels were recorded. A 15-point global rating of change (GROC) scale was used to measure perceived change after the intervention. Results: After 6 weeks of forefoot run training, mean postrun anterior compartment pressures significantly decreased from 78.4 +/- 32.0 mm Hg to 38.4 +/- 11.5 mm Hg. Vertical ground-reaction force and impulse values were significantly reduced. Running distance significantly increased from 1.4 +/- 0.6 km before intervention to 4.8 +/- 0.5 km 6 weeks after intervention, while reported pain while running significantly decreased. The Single Assessment Numeric Evaluation (SANE) significantly increased from 49.9 +/- 21.4 to 90.4 +/- 10.3, and the Lower Leg Outcome Survey (LLOS) significantly increased from 67.3 +/- 13.7 to 91.5 +/- 8.5. The GROC scores at 6 weeks after intervention were between 5 and 7 for all patients. One year after the intervention, the SANE and LLOS scores were greater than reported during the 6-week follow-up. Two-mile run times were also significantly faster than preintervention values. No patient required surgery. Conclusion: In 10 consecutive patients with CECS, a 6-week forefoot strike running intervention led to decreased postrunning lower leg intracompartmental pressures. Pain and disability typically associated with CECS were greatly reduced for up to 1 year after intervention. Surgical intervention was avoided for all patients. C1 [Diebal, Angela R.; Gregory, Robert; Alitz, Curtis; Gerber, J. Parry] Keller Army Community Hosp, West Point, NY 10996 USA. RP Diebal, AR (reprint author), Keller Army Community Hosp, West Point, NY 10996 USA. EM angie.diebal@us.army.mil NR 59 TC 48 Z9 49 U1 1 U2 61 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY PY 2012 VL 40 IS 5 BP 1060 EP 1067 DI 10.1177/0363546512439182 PG 8 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 932XN UT WOS:000303323900015 PM 22427621 ER PT J AU Williams, RL Sroussi, NY Abercrombie, JJ Leung, K Marucha, PT AF Williams, Richard L. Sroussi, Nerve Y. Abercrombie, Johnathan J. Leung, Kai Marucha, Phillip T. TI Synthetic decapeptide reduces bacterial load and accelerates healing in the wounds of restraint-stressed mice SO BRAIN BEHAVIOR AND IMMUNITY LA English DT Article DE Antimicrobial peptide; Wound healing; Toll-like receptor-4; Bacterial clearance; Inflammation; Tri-block copolymer; Nanocarrier; Drug delivery ID TOLL-LIKE RECEPTORS; DRUG-DELIVERY SYSTEMS; ANTIMICROBIAL DECAPEPTIDE; INNATE IMMUNITY; RHEUMATOID-ARTHRITIS; ACTIVATION; INFECTION; PROTEASES; ROLES; LIPOPOLYSACCHARIDE AB Wound healing is a complex process involving four transitional yet concurrent stages: coagulation, inflammation, cell proliferation/epithelialization and remodeling. These overlapping stages occur uneventfully in normal physiology. However, during psychological stress, the inflammatory response can become dysregulated and result in increased susceptibility to bacterial infection and delayed wound closure. In our restraint stress model, cutaneous wounds of stressed SKH-1 mice demonstrate significantly higher levels of bacterial load, and healing progresses at a rate 30% slower, than in non-stressed mice. The purpose of this study was to test the hypothesis that a synthetic antimicrobial decapeptide (KSLW) enhances bacterial clearance during stress-impaired healing in mice. Here, using a Pluronic block copolymer nanocarrier, we endeavored to identify an efficient drug delivery system for KSLW, which would enhance the stability, substantivity and function of the cationic peptide in delayed-healing wounds. In this study, intradermal treatment of excisional wounds of stressed mice with 2 mg/ml KSLW loaded in Pluronic F68, resulted in a sustained antimicrobial effect through post-operative day 5, with a 2-log (p < 0.01) reduction in bacterial load compared with other stressed mice. The demonstrated bacterial reduction in KSLW-treated stressed mice did not approach the levels observed among control mice. Furthermore, treatment of stressed mice with KSLW improved healing, resulting in significantly faster (p < 0.05) wound closure from days 2 to 5 post-wounding, relative to untreated stressed mice and stressed mice treated with Pluronic alone. These findings suggest that Pluronic F68 is an efficient carrier for KSLW, which improves its stability and activity in impaired dermal wounds. Published by Elsevier Inc. C1 [Williams, Richard L.; Abercrombie, Johnathan J.; Leung, Kai] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Sroussi, Nerve Y.] Univ Illinois, Dept Oral Med & Diagnost Sci, Coll Dent, Chicago, IL 60612 USA. [Marucha, Phillip T.] Univ Illinois, Ctr Wound Healing & Tissue Regenerat, Coll Dent, Chicago, IL 60612 USA. RP Williams, RL (reprint author), USA, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM richard.williams15@amedd.army.mil FU United States Army FX This work was supported by a Grant from the United States Army. NR 60 TC 6 Z9 8 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0889-1591 J9 BRAIN BEHAV IMMUN JI Brain Behav. Immun. PD MAY PY 2012 VL 26 IS 4 BP 588 EP 596 DI 10.1016/j.bbi.2012.01.020 PG 9 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 929PV UT WOS:000303078800012 PM 22329957 ER PT J AU Brunye, TT Gardony, A Mahoney, CR Taylor, HA AF Brunye, Tad T. Gardony, Aaron Mahoney, Caroline R. Taylor, Holly A. TI Body-specific representations of spatial location SO COGNITION LA English DT Article DE Spatial cognition; Embodied cognition; Emotion ID COGNITIVE MAPS; MENTAL REPRESENTATIONS; INDIVIDUAL-DIFFERENCES; DISTANCE ESTIMATION; WORKING-MEMORY; LEFT-HANDERS; HANDEDNESS; INFORMATION; ROUTE; ENVIRONMENTS AB The body specificity hypothesis (Casasanto, 2009) posits that the way in which people interact with the world affects their mental representation of information. For instance, right- versus left-handedness affects the mental representation of affective valence, with right-handers categorically associating good with rightward areas and bad with leftward areas, and left-handers doing the opposite. In two experiments we test whether this hypothesis can: extend to spatial memory, be measured in a continuous manner, be predicted by extent of handedness, and how the application of such a heuristic might vary as a function of informational specificity. Experiment 1 demonstrates systematic and continuous spatial location memory biases as a function of associated affective information: right-handed individuals misremembered positively- and negatively-valenced locations as further right and left, respectively, relative to their original locations. Left-handed individuals did the opposite, and in general those with stronger right- or left-handedness showed greater spatial memory biases. Experiment 2 tested whether participants would show similar effects when studying a map with high visual specificity (i.e., zoomed in); they did not. Overall we support the hypothesis that handedness affects the coding of affective information, and better specify the scope and nature of body-specific effects on spatial memory. Published by Elsevier B.V. C1 [Brunye, Tad T.; Gardony, Aaron; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Gardony, Aaron; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbrunye@alumni.tufts.edu NR 75 TC 17 Z9 18 U1 1 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0010-0277 J9 COGNITION JI Cognition PD MAY PY 2012 VL 123 IS 2 BP 229 EP 239 DI 10.1016/j.cognition.2011.07.01 PG 11 WC Psychology, Experimental SC Psychology GA 930XL UT WOS:000303178000003 PM 22386635 ER PT J AU Goethals, PL Cho, BR AF Goethals, P. L. Cho, B. R. TI The optimal process mean problem: Integrating predictability and profitability into an experimental factor space SO COMPUTERS & INDUSTRIAL ENGINEERING LA English DT Article DE Quality; Response surface methodology; Desirability function; Optimal process mean; Factor space ID SKEW-NORMAL-DISTRIBUTION; PRODUCTION RUN; QUALITY CHARACTERISTICS; JOINT DETERMINATION; TARGET VALUE; CANNING PROBLEM; PRODUCTS; MODEL; SELECTION; DESIGN AB For complex manufacturing systems, process or product optimization can be instrumental in achieving a significant economic advantage. To reduce costs associated with product non-conformance or excessive waste, engineers often identify the most critical quality characteristics and then use methods to obtain their ideal parameter settings. The optimal process mean problem is one such statistical method; it begins with the assumption of the characteristic parameters, whereby the ideal settings are determined based upon the tradeoff among various processing costs. Unfortunately, however, the ideal parameter settings for a characteristic mean can be unpredictable, as it is directly influenced by changes in the process variability, tolerance, and cost structure. In this paper, a method is proposed that relates the optimal process mean to the ideal settings through experimental design. With the method, one may gain greater predictability of the new optimal process mean when the process conditions are altered. The methodology is illustrated for a process with multiple mixed quality characteristics; such an optimal process mean problem is seldom treated in the literature. Published by Elsevier Ltd. C1 [Goethals, P. L.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Cho, B. R.] Clemson Univ, Dept Ind Engn, Clemson, SC 29634 USA. RP Goethals, PL (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM paul.goethals@usma.edu; bcho@clemson.edu NR 44 TC 2 Z9 2 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-8352 J9 COMPUT IND ENG JI Comput. Ind. Eng. PD MAY PY 2012 VL 62 IS 4 BP 851 EP 869 DI 10.1016/j.cie.2011.11.032 PG 19 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA 929UZ UT WOS:000303092500002 ER PT J AU Lomonaco, R Ortiz-Lopez, C Orsak, B Webb, A Hardies, J Darland, C Finch, J Gastaldelli, A Harrison, S Tio, F Cusi, K AF Lomonaco, Romina Ortiz-Lopez, Carolina Orsak, Beverly Webb, Amy Hardies, Jean Darland, Celia Finch, Joan Gastaldelli, Amalia Harrison, Stephen Tio, Fermin Cusi, Kenneth TI Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease SO HEPATOLOGY LA English DT Article ID STELLATE CELL ACTIVATION; DEPENDENT DIABETES-MELLITUS; ACID-METABOLISM; PPAR-GAMMA; STEATOHEPATITIS; ADIPONECTIN; GLUCOSE; LIPOTOXICITY; MECHANISMS; SECRETION AB The role of adipose tissue insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains unclear. To evaluate this, we measured in 207 patients with NAFLD (age = 51 +/- 1, body mass index = 34.1 +/- 0.3 kg/m2) and 22 controls without NAFLD (no NAFLD) adipose tissue insulin resistance by means of a validated index (Adipo-IRi = plasma free fatty acids [FFA] x insulin [FPI] concentration) and as the suppression of plasma FFA during an oral glucose tolerance test and by a low-dose insulin infusion. We also explored the relationship between adipose tissue insulin resistance with metabolic and histological parameters by dividing them based on quartiles of adipose tissue insulin resistance (Adipo-IRi quartiles: Q1 = more sensitive; Q4 = more insulin resistant). Hepatic insulin resistance, measured as an index derived from endogenous glucose production x FPI (HIRi), and muscle insulin sensitivity, were assessed during a euglycemic insulin clamp with 3-[3H] glucose. Liver fat was measured by magnetic resonance imaging and spectroscopy, and a liver biopsy was performed to assess liver histology. Compared to patients without steatosis, patients with NAFLD were insulin resistant at the level of adipose tissue, liver, and skeletal muscle and had higher plasma aspartate aminotransferase and alanine aminotransferase, triglycerides, and lower high-density lipoprotein cholesterol and adiponectin levels (all P < 0.01). Metabolic parameters, hepatic insulin resistance, and liver fibrosis (but not necroinflammation) deteriorated as quartiles of adipose tissue insulin resistance worsened (all P < 0.01). Conclusion: Adipose tissue insulin resistance plays a key role in the development of metabolic and histological abnormalities of obese patients with NAFLD. Treatment strategies targeting adipose tissue insulin resistance (e.g., weight loss and thiazolidinediones) may be of value in this population. (HEPATOLOGY 2012) C1 [Cusi, Kenneth] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Diabet Div, Audie L Murphy Vet Adm Med Ctr, San Antonio, TX 78229 USA. [Webb, Amy] Univ Texas Hlth Sci Ctr San Antonio, Div Hepatol, San Antonio, TX 78229 USA. [Hardies, Jean] Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Ctr, San Antonio, TX 78229 USA. [Tio, Fermin] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Harrison, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. RP Cusi, K (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Diabet Div, Audie L Murphy Vet Adm Med Ctr, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM cusi@uthscsa.edu RI Gastaldelli, Amalia/H-3319-2014; webb, andrew/G-9642-2016 OI Gastaldelli, Amalia/0000-0003-2594-1651; FU Burroughs Wellcome Fund; American Diabetes Association [1-08-CR-08]; Veterans Affairs Merit Award [1 I01 CX000167-01]; Veterans Affairs Medical Research Fund; National Center for Research Resources [UL 1RR025767] FX This work was supported by the Burroughs Wellcome Fund (to K.C.), the American Diabetes Association (1-08-CR-08; to K.C.), and a Veterans Affairs Merit Award (1 I01 CX000167-01; to K.C.), the Veterans Affairs Medical Research Fund, and the National Center for Research Resources (award no.: UL 1RR025767). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources of the National Institutes of Health. NR 47 TC 98 Z9 101 U1 2 U2 10 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD MAY PY 2012 VL 55 IS 5 BP 1389 EP 1397 DI 10.1002/hep.25539 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 929GN UT WOS:000303049400009 PM 22183689 ER PT J AU Callison, MC Nussbaum, MA AF Callison, Myrna C. Nussbaum, Maury A. TI Identification of physically demanding patient-handling tasks in an acute care hospital SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE Nursing; Patient-handling; Physical demands ID ERGONOMIC EVALUATION; PREVENTION PROGRAM; WORK; DEVICES; NURSES; INJURY AB Work-related musculoskeletal disorders are prevalent among nurses and other healthcare workers worldwide, and patient-handling tasks are a common precipitating event. Existing research has focused on patient-handling within long-term care facilities and has identified physically demanding patient-handling tasks within this context. It is not known, however, whether nurses in acute care facilities have similar exposures. Using on-site work sampling procedures and a subsequent survey, the primary aim of the present study was to identify, describe, and rank the physically demanding patient-handling tasks performed by nursing staff in an acute care facility. The 10 most physically demanding patient-handling tasks were identified and contrasted with earlier results. Compared to long-term care facilities, in which the majority of tasks have been shown to be associated with performance of activities of daily living, the most frequently observed tasks in the acute care faci lity were repositioning tasks. Differences in the types of transfers being performed across types of healthcare facilities, as well as across units within acute care facilities, highlight the importance of determining the patient-handling demands and needs that are unique to each type of healthcare facility. Generalizing across facilities or units may lead to incorrect assumptions and conclusions about physical demands being placed on nurses. Relevance to industry: Knowledge of the most physically demanding tasks can facilitate future intervention efforts to control exposures and injury risks. Differences in physically demanding tasks likely exist between types of healthcare facilities and suggest distinct approaches are needed. (C) 2012 Elsevier B.V. All rights reserved. C1 [Callison, Myrna C.; Nussbaum, Maury A.] Virginia Tech, Dept Ind & Syst Engn, Blacksburg, VA 24061 USA. [Callison, Myrna C.] USA, Publ Hlth Command, Washington, DC USA. [Nussbaum, Maury A.] Virginia Tech, Sch Biomed Engn & Sci, Blacksburg, VA 24061 USA. RP Nussbaum, MA (reprint author), Virginia Tech, Dept Ind & Syst Engn, 250 Durham Hall 0118, Blacksburg, VA 24061 USA. EM nussbaum@vt.edu RI Nussbaum, Maury/A-9655-2008 OI Nussbaum, Maury/0000-0002-1887-8431 FU Johns Hopkins NIOSH Education and Research Center FX The authors wish to acknowledge the contributions of Ms. Robyn Lee and Ms. Judi Schmitt to this article. This work was supported in part by a Pilot Project Research Training Award from the Johns Hopkins NIOSH Education and Research Center. Its contents are solely the responsibility of the authors and do not represent the official views of the sponsor. NR 34 TC 8 Z9 8 U1 1 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD MAY PY 2012 VL 42 IS 3 BP 261 EP 267 DI 10.1016/j.ergon.2012.02.001 PG 7 WC Engineering, Industrial; Ergonomics SC Engineering GA 930YE UT WOS:000303180000001 ER PT J AU Magnuson, ML Satzger, RD Alcaraz, A Brewer, J Fetterolf, D Harper, M Hrynchuk, R McNally, MF Montgomery, M Nottingham, E Peterson, J Rickenbach, M Seidel, JL Wolnik, K AF Magnuson, Matthew L. Satzger, R. Duane Alcaraz, Armando Brewer, Jason Fetterolf, Dean Harper, Martin Hrynchuk, Ronald McNally, Mary F. Montgomery, Madeline Nottingham, Eric Peterson, James Rickenbach, Michael Seidel, Jimmy L. Wolnik, Karen TI Guidelines for the Identification of Unknown Samples for Laboratories Performing Forensic Analyses for Chemical Terrorism SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; chemical terrorism; unknown; unknown samples; identification; sample acceptance; analysis; reporting ID CHROMATOGRAPHY-MASS SPECTROMETRY; CRITERIA AB Since the early 1990s, the FBI Laboratory has sponsored Scientific Working Groups to improve discipline practices and build consensus among the forensic community. The Scientific Working Group on the Forensic Analysis of Chemical, Biological, Radiological and Nuclear Terrorism developed guidance, contained in this document, on issues forensic laboratories encounter when accepting and analyzing unknown samples associated with chemical terrorism, including laboratory capabilities and analytical testing plans. In the context of forensic analysis of chemical terrorism, this guidance defines an unknown sample and addresses what constitutes definitive and tentative identification. Laboratory safety, reporting issues, and postreporting considerations are also discussed. Utilization of these guidelines, as part of planning for forensic analysis related to a chemical terrorism incident, may help avoid unfortunate consequences not only to the public but also to the laboratory personnel. C1 [Magnuson, Matthew L.] US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, Cincinnati, OH 45268 USA. [Satzger, R. Duane; Wolnik, Karen] US FDA, Forens Chem Ctr, Cincinnati, OH 45237 USA. [Alcaraz, Armando] Lawrence Livermore Natl Lab, Forens Sci Ctr, Livermore, CA 94551 USA. [Brewer, Jason; Fetterolf, Dean; Montgomery, Madeline; Rickenbach, Michael] Fed Bur Invest Lab, Quantico, VA 22135 USA. [Harper, Martin] NIOSH, Dept Hlth & Human Serv, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA. [Hrynchuk, Ronald] Royal Canadian Mounted Police, Natl Forens Serv, Winnipeg, MB R3N OE7, Canada. [McNally, Mary F.] USA, Dept Def, RDECOM, Aberdeen Proving Ground, MD 21010 USA. [Nottingham, Eric] US EPA, Natl Enforcement Invest Ctr, Denver Fed Ctr, Lakewood, CO 80225 USA. [Peterson, James] Fed Bur Invest, Aberdeen Proving Ground, MD 21010 USA. [Seidel, Jimmy L.] US EPA, Off Criminal Enforcement Forens & Training, Forens Operat Program, Denver, CO 80225 USA. RP Magnuson, ML (reprint author), US EPA, Natl Homeland Secur Res Ctr, Off Res & Dev, 26 W Martin Luther King Dr, Cincinnati, OH 45268 USA. EM magnuson.matthew@epa.gov NR 21 TC 5 Z9 5 U1 0 U2 17 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 2012 VL 57 IS 3 BP 636 EP 642 DI 10.1111/j.1556-4029.2011.02014.x PG 7 WC Medicine, Legal SC Legal Medicine GA 928QX UT WOS:000302999000009 PM 22211294 ER PT J AU McNamara, JJ McDonald, S Lawrence, JM AF McNamara, James J. McDonald, Sean Lawrence, Jennifer M. TI Characteristics of False Allegation Adult Crimes SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE forensic science; forensic psychology; false allegation crime; false victimization; false report; factitious disorder ID RAPE ALLEGATIONS AB The purpose of this study was to identify common factors in false allegation adult crimes, by examining the dynamics involved in 30 confirmed false allegation cases. The authors conducted a comprehensive review of these adjudicated cases and then completed a collection instrument to capture offender demographics, offense characteristics, and motive. The results indicated that most false allegation crimes were committed by women (73.3%) and Caucasians (93.3%). Data indicated that more interpersonally violent allegations were primarily motivated by attention/sympathy needs (50.0%), whereas more impersonal offenses involved other motivations such as providing an alibi (16.7%) or profit (13.3%). Offenders tended to be younger, high school graduates with no higher education (43.3%). A total of 23.3% of offenders had a prior criminal history. Male offenders appeared as likely as women to be motivated by attention/sympathy; however, men tended to select more violent, nonsexual offenses (e.g., attempted murder) than women. C1 [McNamara, James J.; Lawrence, Jennifer M.] Fed Bur Invest Acad, NCAVC, Fed Bur Invest, Quantico, VA 22135 USA. [McDonald, Sean] Walter Reed Army Med Ctr, Forens Psychol Serv, Washington, DC 20307 USA. RP McNamara, JJ (reprint author), Fed Bur Invest Acad, NCAVC, Fed Bur Invest, Quantico, VA 22135 USA. EM James.mcnamara@ic.fbi.gov FU NCAVC; NCAVC Research Advisory Board FX The authors would like to express their gratitude to NCAVC Research Coordinator Yvonne Muirhead, the members of the NCAVC Research Advisory Board, NCAVC Research Analyst Kari Riddles, and NCAVC Intern Jaclyn Chall for their support of this research project. NR 11 TC 2 Z9 2 U1 1 U2 16 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 2012 VL 57 IS 3 BP 643 EP 646 DI 10.1111/j.1556-4029.2011.02019.x PG 4 WC Medicine, Legal SC Legal Medicine GA 928QX UT WOS:000302999000010 PM 22236499 ER PT J AU Hart, EC Joyner, MJ Wallin, BG Charkoudian, N AF Hart, Emma C. Joyner, Michael J. Wallin, B. Gunnar Charkoudian, Nisha TI Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Review ID SYMPATHETIC-NERVE ACTIVITY; NITRIC-OXIDE SYNTHASE; GENDER-DIFFERENCES; HEALTHY-MEN; ORTHOSTATIC INTOLERANCE; NORADRENALINE SPILLOVER; BAROREFLEX SENSITIVITY; CARDIOVASCULAR EVENTS; ADRENERGIC-RECEPTORS; AUTONOMIC SUPPORT AB Young women tend to have lower blood pressure, and less risk of hypertension, compared to young men. As people age, both blood pressure and the risk of hypertension increase in both sexes; this occurs most strikingly in women after menopause. However, the mechanisms for these influences of sex and age remain incompletely understood. In this review we are specifically interested in the interaction between neural (sympathetic nerve activity; SNA) and haemodynamic factors (cardiac output, blood pressure and vascular resistance) and how these change with sex and age. While peripheral vascular SNA can vary 7- to 10fold among normotensive young men and women, it is reproducible in a given individual. Surprisingly, higher levels of SNA are not associated with higher blood pressures in these groups. In young men, high SNA is associated with higher total peripheral vascular resistance (TPR), and appears to be balanced by lower cardiac output and less peripheral vascular responsiveness to adrenergic stimulation. Young women do not exhibit the SNATPR relationship. Recent evidence suggests that beta adrenergic vasodilatation offsets the vasoconstrictor effects of aadrenergic vasoconstriction in young women, which may contribute to the generally lower blood pressures in this group. Sympathetic nerve activity increases with age, and in groups over 40, levels of SNA are more tightly linked to levels of blood pressure. The potentially protective beta adrenergic effect seen in young women appears to be lost after menopause and probably contributes to the increased blood pressure and increased risk of hypertension seen in older women. C1 [Hart, Emma C.; Joyner, Michael J.] Mayo Clin, Dept Anaesthesiol, Rochester, MN USA. Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA. [Wallin, B. Gunnar] Gothenburg Univ, Sahlgren Acad, Inst Neurosci & Physiol, Gothenburg, Sweden. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Hart, EC (reprint author), Univ Bristol, Dept Physiol & Pharmacol, Med Sci Bldg, Bristol BS8 1TD, Avon, England. EM pyecjh@bristol.ac.uk OI Hart, Emma/0000-0002-4534-9586 NR 67 TC 49 Z9 49 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PD MAY PY 2012 VL 590 IS 9 BP 2069 EP 2079 DI 10.1113/jphysiol.2011.224642 PG 11 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 931TJ UT WOS:000303241900004 PM 22351633 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI At the Precipice: Americans North and South during the Secession Crisis SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Washington, DC 20310 USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 EI 2325-6893 J9 J SOUTHERN HIST JI J. South. Hist. PD MAY PY 2012 VL 78 IS 2 BP 466 EP 467 PG 2 WC History SC History GA 932MS UT WOS:000303295800035 ER PT J AU Kim, S Kang, YQ Krueger, CA Sen, ML Holcomb, JB Chen, D Wenke, JC Yang, YZ AF Kim, Sungwoo Kang, Yunqing Krueger, Chad A. Sen, Milan Holcomb, John B. Chen, Di Wenke, Joseph C. Yang, Yunzhi TI Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation SO ACTA BIOMATERIALIA LA English DT Article DE Chitosan; Gelatin microspheres; Glyoxal; BMP-2; IGF-1 ID GROWTH-FACTOR DELIVERY; MARROW STROMAL CELLS; IN-VITRO; CROSS-LINKING; BMP-2/BMP-7 DELIVERY; TISSUE REGENERATION; CONTROLLED-RELEASE; LOCAL-DELIVERY; BONE; SCAFFOLDS AB The purpose of this study was to develop and characterize a chitosan gel/gelatin microsphere (MSs) dual delivery system for sequential release of bone morphogenetic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) to enhance osteoblast differentiation in vitro. We made and characterized the delivery system based on its degree of cross-linking, degradation, and release kinetics. We also evaluated the cytotoxicity of the delivery system and the effect of growth factors on cell response using pre-osteoblast W-20-17 mouse bone marrow stromal cells. IGF-1 was first loaded into MSs, and then the IGF-1-containing MSs were encapsulated into the chitosan gel which contained BMP-2. Cross-linking of gelatin with glyoxal via Schiff bases significantly increased thermal stability and decreased the solubility of the MSs, leading to a significant decrease in the initial release of IGF-1. Encapsulation of the MSs into the chitosan gel generated polyelectrolyte complexes by intermolecular interactions, which further affected the release kinetics of IGF-1. This combinational delivery system provided an initial release of BMP-2 followed by a slow and sustained release of IGF-1. Significantly greater alkaline phosphatase activity was found in W-20-17 cells treated with the sequential delivery system compared with other treatments (P < 0.05) after a week of culture. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Kim, Sungwoo; Kang, Yunqing; Yang, Yunzhi] Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA. [Krueger, Chad A.; Wenke, Joseph C.] USA, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, San Antonio, TX USA. [Sen, Milan] Univ Texas Hlth Sci Ctr Houston, Dept Orthoped Surg, Houston, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Ctr Translat Injury Res, Houston, TX USA. [Chen, Di] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA. RP Yang, YZ (reprint author), Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA. EM ypyang@stanford.edu FU DOD [W81XWH-10-1-0966]; Airlift Research Foundation; Wallace H. Coulter Foundation; March of Dimes Birth Defect Foundation; NIH from NIAMS [R01AR057837]; NIH from NIDCR [R01DE021468] FX We acknowledge the grant supports from DOD W81XWH-10-1-0966, Airlift Research Foundation, Wallace H. Coulter Foundation, March of Dimes Birth Defect Foundation, NIH R01AR057837 from NIAMS and NIH R01DE021468 from NIDCR. NR 50 TC 55 Z9 59 U1 3 U2 65 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1742-7061 J9 ACTA BIOMATER JI Acta Biomater. PD MAY PY 2012 VL 8 IS 5 BP 1768 EP 1777 DI 10.1016/j.actbio.2012.01.009 PG 10 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 928NL UT WOS:000302989700012 PM 22293583 ER PT J AU Fomovska, A Huang, QQ El Bissati, K Mui, EJ Witola, WH Cheng, G Zhou, Y Sommerville, C Roberts, CW Bettis, S Prigge, ST Afanador, GA Hickman, MR Lee, PJ Leed, SE Auschwitz, JM Pieroni, M Stec, J Muench, SP Rice, DW Kozikowski, AP McLeod, R AF Fomovska, Alina Huang, Qingqing El Bissati, Kamal Mui, Ernest J. Witola, William H. Cheng, Gang Zhou, Ying Sommerville, Caroline Roberts, Craig W. Bettis, Sam Prigge, Sean T. Afanador, Gustavo A. Hickman, Mark R. Lee, Patty J. Leed, Susan E. Auschwitz, Jennifer M. Pieroni, Marco Stec, Jozef Muench, Stephen P. Rice, David W. Kozikowski, Alan P. McLeod, Rima TI Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID TOXOPLASMA-GONDII; TRYPANOSOMA-CRUZI; LYTIC VACUOLES; AP-3 ADAPTER; ARABIDOPSIS; PROTEIN; BIOGENESIS; GROWTH; ACIDOCALCISOMES; TRAFFICKING AB Toxoplasma gondii is a protozoan parasite that can damage the human brain and eyes. There are no curative medicines. Herein, we describe our discovery of N-benzoyl-2-hydroxybenzamides as a class of compounds effective in the low nanomolar range against T. gondii in vitro and in vivo. Our lead compound, QQ-437, displays robust activity against the parasite and could be useful as a new scaffold for development of novel and improved inhibitors of T. gondii. Our genome-wide investigations reveal a specific mechanism of resistance to N-benzoyl-2-hydroxybenzamides mediated by adaptin-3 beta, a large protein from the secretory protein complex. N-Benzoyl-2-hydroxybenzamide-resistant clones have alterations of their secretory pathway, which traffics proteins to micronemes, rhoptries, dense granules, and acidocalcisomes/plant-like vacuole (PLVs). N-Benzoyl-2-hydroxybenzamide treatment also alters micronemes, rhoptries, the contents of dense granules, and, most markedly, acidocalcisomes/PLVs. Furthermore, QQ-437 is active against chloroquine-resistant Plasmodium falciparum. Our studies reveal a novel class of compounds that disrupts a unique secretory pathway of T. gondii, with the potential to be used as scaffolds in the search for improved compounds to treat the devastating diseases caused by apicomplexan parasites. C1 [Fomovska, Alina; El Bissati, Kamal; Mui, Ernest J.; Witola, William H.; Zhou, Ying; Bettis, Sam; McLeod, Rima] Univ Chicago, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Comm Genet, Chicago, IL 60637 USA. [Fomovska, Alina; El Bissati, Kamal; Mui, Ernest J.; Witola, William H.; Zhou, Ying; Bettis, Sam; McLeod, Rima] Univ Chicago, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Comm Immunol, Chicago, IL 60637 USA. [Fomovska, Alina; El Bissati, Kamal; Mui, Ernest J.; Witola, William H.; Zhou, Ying; Bettis, Sam; McLeod, Rima] Univ Chicago, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Comm Mol Med, Chicago, IL 60637 USA. [Huang, Qingqing; Cheng, Gang; Pieroni, Marco; Stec, Jozef; Kozikowski, Alan P.] Univ Illinois, Dept Med Chem & Pharmacognosy, Drug Discovery Program, Chicago, IL USA. [Sommerville, Caroline; Roberts, Craig W.] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland. [Prigge, Sean T.; Afanador, Gustavo A.] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA. [Hickman, Mark R.; Lee, Patty J.; Leed, Susan E.; Auschwitz, Jennifer M.] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Discovery, Silver Spring, MD USA. [Muench, Stephen P.] Univ Leeds, Inst Membrane & Syst Biol, Leeds, W Yorkshire, England. [Rice, David W.] Univ Sheffield, Dept Mol Biol, Sheffield, S Yorkshire, England. RP McLeod, R (reprint author), Univ Chicago, Dept Ophthalmol & Visual Sci, Inst Genom & Syst Biol, Comm Genet, Chicago, IL 60637 USA. EM rmcleod@uchicago.edu RI Roberts, Craig/B-8016-2008; Huang, Qingqing/M-6824-2013; OI Pieroni, Marco/0000-0001-9190-3712; Roberts, Craig/0000-0002-0653-835X; Huang, Qingqing/0000-0001-7080-7588; Muench, Stephen/0000-0001-6869-4414 FU NIAID NIH DMID [U01 AI082180]; Institute for Genomics, Genetics, and Systems Biology, University of Chicago; MRC FX This work was supported by NIAID NIH DMID U01 AI082180, the Institute for Genomics, Genetics, and Systems Biology, University of Chicago, and by gifts from the Mann and Cornwell, Taub, Rooney-Alden, Engel, Pritzker, Harris, Zucker, and Mussilami families. S. P. M. is supported by an MRC Career Development fellowship. NR 59 TC 17 Z9 17 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 2012 VL 56 IS 5 BP 2666 EP 2682 DI 10.1128/AAC.06450-11 PG 17 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 925VQ UT WOS:000302790400063 PM 22354304 ER PT J AU Bednar, AJ Russell, AL Hayes, CA Jones, WT Tackett, P Splichal, DE Georgian, T Parker, LV Kirgan, RA MacMillan, DK AF Bednar, A. J. Russell, A. L. Hayes, C. A. Jones, W. T. Tackett, P. Splichal, D. E. Georgian, T. Parker, L. V. Kirgan, R. A. MacMillan, D. K. TI Analysis of munitions constituents in groundwater using a field-portable GC-MS SO CHEMOSPHERE LA English DT Article DE Munitions constituents; Field analysis; GC-MS; Detection and identification AB The use of munitions constituents (MCs) at military installations can produce soil and groundwater contamination that requires periodic monitoring even after training or manufacturing activities have ceased. Traditional groundwater monitoring methods require large volumes of aqueous samples (e.g., 2-4 L) to be shipped under chain of custody, to fixed laboratories for analysis. The samples must also be packed on ice and shielded from light to minimize degradation that may occur during transport and storage. The laboratory's turn-around time for sample analysis and reporting can be as long as 45 d. This process hinders the reporting of data to customers in a timely manner; yields data that are not necessarily representative of current site conditions owing to the lag time between sample collection and reporting; and incurs significant shipping costs for samples. The current work compares a field portable Gas Chromatograph-Mass Spectrometer (GC-MS) for analysis of MCs on-site with traditional laboratory-based analysis using High Performance Liquid Chromatography with UV absorption detection. The field method provides near real-time (within similar to 1 h of sampling) concentrations of MCs in groundwater samples. Mass spectrometry provides reliable confirmation of MCs and a means to identify unknown compounds that are potential false positives for methods with UV and other non-selective detectors. Published by Elsevier Ltd. C1 [Bednar, A. J.; Jones, W. T.; Kirgan, R. A.; MacMillan, D. K.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Russell, A. L.; Hayes, C. A.] Badger Tech Serv, Vicksburg, MS USA. [Splichal, D. E.; Georgian, T.] USA, Corps Engineers Environm & Munit Ctr Expertise, Omaha, NE USA. [Parker, L. V.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Tackett, P.] FLIR, W Lafayette, IN USA. RP Bednar, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil FU United States Army Corps of Engineers; Department of Defense; USAERDC FX The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the US Government. The tests described and the resulting data presented herein, unless otherwise noted, were obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers and the Environmental Security Technology Certification Program (Project E-ER1-0922) of the Department of Defense by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. The authors are grateful for the hard work, support, and accommodation by ARCADIS employees who assisted in field sampling at the Milan, TN site. The authors also thank Christopher Griggs and Manoj Shukla of the USACE for their editorial comments. NR 15 TC 7 Z9 8 U1 3 U2 20 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAY PY 2012 VL 87 IS 8 BP 894 EP 901 DI 10.1016/j.chemosphere.2012.01.042 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 928MY UT WOS:000302988100010 PM 22349064 ER PT J AU Handy, RD van den Brink, N Chappell, M Muhling, M Behra, R Dusinska, M Simpson, P Ahtiainen, J Jha, AN Seiter, J Bednar, A Kennedy, A Fernandes, TF Riediker, M AF Handy, Richard D. van den Brink, Nico Chappell, Mark Muehling, Martin Behra, Renata Dusinska, Maria Simpson, Peter Ahtiainen, Jukka Jha, Awadhesh N. Seiter, Jennifer Bednar, Anthony Kennedy, Alan Fernandes, Teresa F. Riediker, Michael TI Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far? SO ECOTOXICOLOGY LA English DT Article DE Nanoparticle characterisation; OECD test method; Gram positive Bacteria; Earthworm; Aquatic tests; Bioaccumulation factor tests ID WALLED CARBON-NANOTUBES; NEMATODE CAENORHABDITIS-ELEGANS; TITANIUM-DIOXIDE NANOPARTICLES; ENVIRONMENTAL RISK-ASSESSMENT; FULLERENE WATER SUSPENSIONS; SOIL MICROBIAL COMMUNITY; DNA STRAND BREAKS; IN-VITRO; SILVER NANOPARTICLES; RAINBOW-TROUT AB This review paper reports the consensus of a technical workshop hosted by the European network, NanoImpactNet (NIN). The workshop aimed to review the collective experience of working at the bench with manufactured nanomaterials (MNMs), and to recommend modifications to existing experimental methods and OECD protocols. Current procedures for cleaning glassware are appropriate for most MNMs, although interference with electrodes may occur. Maintaining exposure is more difficult with MNMs compared to conventional chemicals. A metal salt control is recommended for experiments with metallic MNMs that may release free metal ions. Dispersing agents should be avoided, but if they must be used, then natural or synthetic dispersing agents are possible, and dispersion controls essential. Time constraints and technology gaps indicate that full characterisation of test media during ecotoxicity tests is currently not practical. Details of electron microscopy, dark-field microscopy, a range of spectroscopic methods (EDX, XRD, XANES, EXAFS), light scattering techniques (DLS, SLS) and chromatography are discussed. The development of user-friendly software to predict particle behaviour in test media according to DLVO theory is in progress, and simple optical methods are available to estimate the settling behaviour of suspensions during experiments. However, for soil matrices such simple approaches may not be applicable. Alternatively, a Critical Body Residue approach may be taken in which body concentrations in organisms are related to effects, and toxicity thresholds derived. For microbial assays, the cell wall is a formidable barrier to MNMs and end points that rely on the test substance penetrating the cell may be insensitive. Instead assays based on the cell envelope should be developed for MNMs. In algal growth tests, the abiotic factors that promote particle aggregation in the media (e.g. ionic strength) are also important in providing nutrients, and manipulation of the media to control the dispersion may also inhibit growth. Controls to quantify shading effects, and precise details of lighting regimes, shaking or mixing should be reported in algal tests. Photosynthesis may be more sensitive than traditional growth end points for algae and plants. Tests with invertebrates should consider non-chemical toxicity from particle adherence to the organisms. The use of semi-static exposure methods with fish can reduce the logistical issues of waste water disposal and facilitate aspects of animal husbandry relevant to MMNs. There are concerns that the existing bioaccumulation tests are conceptually flawed for MNMs and that new test(s) are required. In vitro testing strategies, as exemplified by genotoxicity assays, can be modified for MNMs, but the risk of false negatives in some assays is highlighted. In conclusion, most protocols will require some modifications and recommendations are made to aid the researcher at the bench. C1 [Handy, Richard D.; Jha, Awadhesh N.] Univ Plymouth, Sch Biomed & Biol Sci, Ecotoxicol Res & Innovat Ctr, Plymouth PL4 8AA, Devon, England. [van den Brink, Nico] Wageningen UR, Alterra, NL-6700 AA Wageningen, Netherlands. [Chappell, Mark; Seiter, Jennifer; Bednar, Anthony; Kennedy, Alan] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Muehling, Martin] TU Bergakad Freiberg, Inst Biol Sci, D-09599 Freiberg, Germany. [Behra, Renata] Eawag, Swiss Fed Inst Aquat Sci & Technol, Dubendorf, Switzerland. [Dusinska, Maria] NILU Norwegian Inst Air Res, CEE, Hlth Effects Lab, N-2027 Kjeller, Norway. [Dusinska, Maria] Slovak Med Univ, Bratislava 83302, Slovakia. [Ahtiainen, Jukka] Finnish Safety & Chem Agcy, Helsinki 00521, Finland. [Fernandes, Teresa F.] Heriot Watt Univ, Sch Life Sci, Edinburgh EH14 4AS, Midlothian, Scotland. [Riediker, Michael] IST, Inst Work & Hlth, CH-1011 Lausanne, Switzerland. RP Handy, RD (reprint author), Univ Plymouth, Sch Biomed & Biol Sci, Ecotoxicol Res & Innovat Ctr, Plymouth PL4 8AA, Devon, England. EM rhandy@plymouth.ac.uk OI Fernandes, Teresa/0000-0002-8541-598X; Riediker, Michael/0000-0002-5268-864X FU European Union [NMP4-CA-2008-218539]; Natural Environment Research Council, UK [NE/G001812/1] FX The authors would like to thank all those who participated in the discussions at the NanoImpactNet workshop held in Dublin during September 2010. Funding from the European Union's 7th Framework Programme Coordination Action NanoImpactNet (NMP4-CA-2008-218539) to the workshop is acknowledged. In addition, R. Handy was supported by the Natural Environment Research Council, UK (NE/G001812/1). NR 197 TC 83 Z9 83 U1 10 U2 212 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0963-9292 J9 ECOTOXICOLOGY JI Ecotoxicology PD MAY PY 2012 VL 21 IS 4 BP 933 EP 972 DI 10.1007/s10646-012-0862-y PG 40 WC Ecology; Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 925ZK UT WOS:000302800900001 PM 22422174 ER PT J AU Liu, N Xu, ZY Sadler, BM AF Liu, Ning Xu, Zhengyuan Sadler, Brian M. TI Geolocation Performance With Biased Range Measurements SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Biased estimation; geolocation; multipath channel; nonline-of-sight (NLOS); range measurements; source localization; time delay ID WIRELESS SENSOR NETWORKS; LOCALIZATION; ENVIRONMENTS; BOUNDS AB We study geolocation based on biased range estimates. Positive bias arises using time delay ranging methods in a multipath fading environment, when the line of sight direct path is severely attenuated. We model the range measurement as contaminated with Gaussian noise and an additive nonnegative bias term, and consider deterministic and random bias cases. We develop weighted least squares (WLS) and maximum likelihood (ML) geolocation estimators, and show that in general they yield biased geolocation estimates. A perturbation analysis technique is applied to find bias and mean square error (MSE) expressions for the WLS and MLE algorithms. MLE generally outperforms WLS, because MLE exploits knowledge of the range measurement bias distribution. The location error expressions are functions of the measurement bias and variance, as well as the network geometry. These results are useful to study achievable geolocation performance, and are applied to optimize sensor placement for improving the overall geolocation accuracy. We also develop the Cramer-Rao bound (CRB) on geolocation for our model. The CRB is a bound on unbiased estimation, whereas the geolocation algorithms may be biased, and we show how the estimators approach the CRB in certain cases. Numerical examples are presented to verify the analysis and study some cases of interest. C1 [Liu, Ning] Univ Calif Riverside, Riverside, CA 92521 USA. [Xu, Zhengyuan] Tsinghua Univ, Dept Elect Engn, Beijing 100084, Peoples R China. [Xu, Zhengyuan] Tsinghua Univ, Tsinghua Natl Lab Informat Sci & Technol, Beijing 100084, Peoples R China. [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Liu, N (reprint author), Broadcom Corp, Irvine, CA 92617 USA. EM ningliu@broadcom.com; xuzy@tsinghua.edu.cn; brian.m.sadler6.civ@mail.mil FU Army Research Laboratory CTA on Communications and Networks [DAAD19-01-2-0011]; National Nature Science Foundation of China [60928001] FX This work was supported in part by the Army Research Laboratory CTA on Communications and Networks by Grant DAAD19-01-2-0011 and by the National Nature Science Foundation of China by Grant 60928001. A preliminary version of this paper was presented at the 46th Annual Allerton Conference 2008, Urbana-Champaign, IL, September 2008 [1]. NR 21 TC 9 Z9 9 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAY PY 2012 VL 60 IS 5 BP 2315 EP 2329 DI 10.1109/TSP.2012.2187645 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 927VQ UT WOS:000302938800017 ER PT J AU Liu, WN Sun, X Chen, WN Templeton, D AF Liu, Wenning Sun, Xin Chen, Weinong Templeton, Douglas TI Modeling and Characterization of Dynamic Failure of Soda-lime Glass Under High-Speed Impact SO INTERNATIONAL JOURNAL OF DAMAGE MECHANICS LA English DT Article DE soda-lime glass; brittle failure; multi-axial loading; shear failure; failure strength; damage mode; continuum damage mechanics; split Hopkinson pressure bar ID CONTINUUM DAMAGE MECHANICS; SMALL STEEL SPHERES; BOROSILICATE GLASS; ANOMALOUS GLASSES; MATERIAL RESPONSE; INDENTATION; FRACTURE; SURFACES; RESISTANCE; BEHAVIOR AB In this article, the impact-induced dynamic failure of a soda-lime glass block is studied using an integrated experimental/analytical approach. The Split Hopkinson Pressure Bartechnique is used to conduct dynamic failure test of soda-lime glass first. The damage growth patterns and stress histories are reported for various glass specimen designs. Making use of a continuum damage mechanics-based constitutive model, the initial failure and subsequent stiffness reduction of glass are simulated and investigated. Explicit finite element analyzes are used to simulate the glass specimen impact event. A maximum shear stress-based damage evolution law is used in describing the glass damage process under combined compression/shear loading. The impact test results are used to quantify the critical shear stress for the soda-lime glass under examination. C1 [Liu, Wenning; Sun, Xin] Pacific NW Natl Lab, Richland, WA 99352 USA. [Chen, Weinong] Purdue Univ, AAE Sch, W Lafayette, IN 47907 USA. [Templeton, Douglas] USA, Tank & Automot Res & Dev, AMSRD TAR R, Warren, MI 48397 USA. RP Liu, WN (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA. EM liu_wenning@hotmail.com NR 34 TC 3 Z9 4 U1 4 U2 13 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1056-7895 J9 INT J DAMAGE MECH JI Int. J. Damage Mech. PD MAY PY 2012 VL 21 IS 4 BP 577 EP 598 DI 10.1177/1056789511411430 PG 22 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA 928WY UT WOS:000303020500005 ER PT J AU Youso, SL Rockwood, GA Logue, BA AF Youso, Stephanie L. Rockwood, Gary A. Logue, Brian A. TI The Analysis of Protein-Bound Thiocyanate in Plasma of Smokers and Non-Smokers as a Marker of Cyanide Exposure SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article ID GAS-CHROMATOGRAPHY; TOBACCO-SMOKE; CARBON-MONOXIDE; MEMBRANE SENSOR; WHOLE-BLOOD; SALIVA; URINE; ADDUCTS; ACID; ACCUMULATION C1 [Youso, Stephanie L.; Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Rockwood, Gary A.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu FU National Institutes Of Health Office of the Director; National Institute of Allergy and Infectious Diseases [Y1-OD-0690-01/A-120-B.P2010-01]; USAMRICD under the auspices of the US Army Research Office of Scientific Services [W911NF-11-D-0001]; National Institutes of Health; Department of Defense FX The research was supported by the CounterACT Program, National Institutes Of Health Office of the Director and the National Institute of Allergy and Infectious Diseases, Inter Agency Agreement Number Y1-OD-0690-01/A-120-B.P2010-01 and the USAMRICD under the auspices of the US Army Research Office of Scientific Services Program Contract No. W911NF-11-D-0001 administered by Battelle (Delivery order 0079, Contract No TCN 11077). We gratefully acknowledge funding from the National Institutes of Health and the Department of Defense through the Cyanide Medical Countermeasures and the Medical Diagnostics research areas. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the National Institutes of Health, Department of the Army or the Department of Defense. NR 44 TC 5 Z9 5 U1 1 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD MAY PY 2012 VL 36 IS 4 BP 265 EP 269 DI 10.1093/jat/bks017 PG 5 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 929TJ UT WOS:000303088300006 PM 22474215 ER PT J AU Domanski, JP Park, SJ Harrison, SA AF Domanski, Jeremy P. Park, Stephen J. Harrison, Stephen A. TI Cardiovascular Disease and Nonalcoholic Fatty Liver Disease Does Histologic Severity Matter? SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE NASH; metabolic syndrome; cardiovascular disease; fatty liver; diabetes ID TYPE-2 DIABETIC-PATIENTS; TERM-FOLLOW-UP; NATURAL-HISTORY; RISK; STEATOHEPATITIS; ASSOCIATION; PREVALENCE; EVENTS AB Goals: We aimed to investigate the prevalence of cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH) versus non-NASH fatty liver. Background: Nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of cardiovascular disease, which is a leading cause of death in this patient population. NASH is a subset of NAFLD that carries a higher risk of progression to cirrhosis and its associated complications. Study: We conducted a retrospective chart review of patients with biopsy-confirmed NAFLD, including NASH and non-NASH fatty liver, within the Gastroenterology and Hepatology clinic at Brooke Army Medical Center. Patients with secondary causes of chronic liver disease were excluded. The patients' records were reviewed for the presence of significant cardiovascular disease, which was defined as a history of stroke, unstable angina, myocardial infarction, congestive heart failure, or need for revascularization. Results: Nine hundred thirteen patients were identified and 377 patients met inclusion and exclusion criteria and were included in the final analysis. Of these, 219 patients had biopsies showing the presence of at least grade I NASH. The overall prevalence of cardiovascular disease was 6.63%. After controlling for age, sex, body mass index, and the presence of diabetes, there was no significant increase in the prevalence of cardiovascular disease in the NASH cohort over the non-NASH group. Conclusions: Cardiovascular disease is common among patients with NAFLD. However, no increased risk of cardiovascular disease was found among those patients with NASH as compared with those with non-NASH fatty liver. C1 [Domanski, Jeremy P.; Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. [Park, Stephen J.] Wilford Hall USAF Med Ctr, Dept Med, San Antonio, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, San Antonio, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 17 TC 15 Z9 16 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD MAY-JUN PY 2012 VL 46 IS 5 BP 427 EP 430 DI 10.1097/MCG.0b013e31822fb3f7 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 926GC UT WOS:000302818300015 PM 22469639 ER PT J AU Cho, JH Swami, A Chen, IR AF Cho, Jin-Hee Swami, Ananthram Chen, Ing-Ray TI Modeling and analysis of trust management with trust chain optimization in mobile ad hoc networks SO JOURNAL OF NETWORK AND COMPUTER APPLICATIONS LA English DT Article DE Mobile ad hoc networks; Trust; Trust metric; Trust management; Quality-of-service trust; Social trust; Stochastic Petri nets ID PUBLIC-KEY MANAGEMENT; FRAMEWORK; FUTURE AB We develop and analyze a trust management protocol for mission-driven group communication systems in mobile ad hoc networks using hierarchical modeling techniques based on stochastic Petri nets. Trust among mobile nodes is crucial for team collaborations with new coalition partners without prior interactions for mission-driven group communication systems in battlefield situations. In addition, ensuring a certain level of trust is also critical for successful mission completion. Our work seeks to identify the optimal length of a trust chain among peers in a trust web that generates the most accurate trust levels without revealing risk based on a tradeoff between trust availability and path reliability over trust space. We define a trust metric for mission-driven group communication systems in mobile ad hoc networks to properly reflect unique characteristics of trust concepts and demonstrate that an optimal trust chain length exists for generating the most accurate trust levels for trust-based collaboration among peers in mobile ad hoc networks while meeting trust availability and path reliability requirements. Published by Elsevier Ltd. C1 [Cho, Jin-Hee; Swami, Ananthram] USARL, CISD, Adelphi, MD 20783 USA. [Chen, Ing-Ray] Virginia Polytech State Univ, Dept Comp Sci, Falls Church, VA 22043 USA. RP Cho, JH (reprint author), USARL, CISD, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jinhee.cho@us.army.mil; ananthram.swami@us.army.mil; irchen@vt.edu NR 48 TC 39 Z9 42 U1 3 U2 23 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1084-8045 J9 J NETW COMPUT APPL JI J. Netw. Comput. Appl. PD MAY PY 2012 VL 35 IS 3 BP 1001 EP 1012 DI 10.1016/j.jnca.2011.03.016 PG 12 WC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering SC Computer Science GA 921BC UT WOS:000302452000015 ER PT J AU Clark, PJ Thompson, AJ Zhu, M Vock, DM Zhu, Q Ge, D Patel, K Harrison, SA Urban, TJ Naggie, S Fellay, J Tillmann, HL Shianna, K Noviello, S Pedicone, LD Esteban, R Kwo, P Sulkowski, MS Afdhal, N Albrecht, JK Goldstein, DB McHutchison, JG Muir, AJ AF Clark, P. J. Thompson, A. J. Zhu, M. Vock, D. M. Zhu, Q. Ge, D. Patel, K. Harrison, S. A. Urban, T. J. Naggie, S. Fellay, J. Tillmann, H. L. Shianna, K. Noviello, S. Pedicone, L. D. Esteban, R. Kwo, P. Sulkowski, M. S. Afdhal, N. Albrecht, J. K. Goldstein, D. B. McHutchison, J. G. Muir, A. J. CA IDEAL Investigators TI Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response SO JOURNAL OF VIRAL HEPATITIS LA English DT Article DE cholesterol; hepatitis C virus; interleukin 28B; lipids; sustained viral response ID GENOME-WIDE ASSOCIATION; VIROLOGICAL RESPONSE; RIBAVIRIN THERAPY; INTERFERON-ALPHA; IL28B GENOTYPE; VIRUS; STEATOSIS; INFECTION; PROTEIN; PEGINTERFERON AB Low-density lipoprotein cholesterol (LDL-C) levels and interleukin 28B (IL28B) polymorphism are associated with sustained viral response (SVR) to peginterferon/ribavirin (pegIFN/RBV) for chronic hepatitis C (CHC) infection. IL28B has been linked with LDL-C levels using a candidate gene approach, but it is not known whether other genetic variants are associated with LDL-C, nor how these factors definitively affect SVR. We assessed genetic predictors of serum lipid and triglyceride levels in 1604 patients with genotype 1 (G1) chronic hepatitis C virus (HCV) infection by genome-wide association study and developed multivariable predictive models of SVR. IL28B polymorphisms were the only common genetic variants associated with pretreatment LDL-C level in Caucasians (rs12980275, P = 4.7 x 10(-17), poor response IL28B variants associated with lower LDL-C). The association was dependent on HCV infection, IL28B genotype was no longer associated with LDL-C in SVR patients after treatment, while the association remained significant in non-SVR patients (P < 0.001). LDL-C was significantly associated with SVR for heterozygous IL28B genotype patients (P < 0.001) but not for homozygous genotypes. SVR modelling suggested that IL28B heterozygotes with LDL-C > 130 mg/dL and HCV RNA =600 000 IU/mL may anticipate cure rates >80%, while the absence of these two criteria was associated with an SVR rate of <35%. IL28B polymorphisms are the only common genetic variants associated with pretreatment LDL-C in G1-HCV. LDL-C remains significantly associated with SVR for heterozygous IL28B genotype patients, where LDL-C and HCV RNA burden may identify those patients with high or low likelihood of cure with pegIFN/RBV therapy. C1 [Clark, P. J.] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27715 USA. [Clark, P. J.] Univ New S Wales, Kirby Inst Infect & Immun Soc, Sydney, NSW, Australia. [Zhu, M.; Zhu, Q.; Ge, D.; Urban, T. J.; Fellay, J.; Shianna, K.; Goldstein, D. B.] Duke Univ, Ctr Human Genome Variat, Durham, NC 27715 USA. [Harrison, S. A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Noviello, S.; Pedicone, L. D.; Albrecht, J. K.] Merck & Co Inc, Whitehouse Stn, NJ USA. [Esteban, R.] Hosp Gen Univ Valle de Hebron, Barcelona, Spain. [Kwo, P.] Indiana Univ Sch Med, Indianapolis, IN USA. [Sulkowski, M. S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Afdhal, N.] Harvard Univ, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. RP Clark, PJ (reprint author), Duke Univ, Med Ctr, Duke Clin Res Inst, POB 17969, Durham, NC 27715 USA. EM paul.clark@dm.duke.edu RI Zhu, Mingfu/F-3217-2011; Clark, Paul/A-1480-2012; OI Zhu, Mingfu/0000-0003-0296-712X; Clark, Paul/0000-0002-1821-4969; Vock, David M/0000-0002-5459-9579; Fellay, Jacques/0000-0002-8240-939X FU Merck and Co.; Duke Clinical Research Institute; Richard Boebel Family Fund; National Health and Medical Research Council of Australia [PJC: APP1017139]; Gastroenterological Society of Australia; The Kirby Institute for Infection and Immunity in Society; University of New South Wales, Australia; AASLD/LIFER; Royal Australian College of Physicians FX The study was funded by Schering-Plough Research Institute, Kenilworth, NJ (now Merck and Co.). Drs Clark and Thompson received funding support from the Duke Clinical Research Institute, the Richard Boebel Family Fund, the National Health and Medical Research Council of Australia (PJC: APP1017139) and the Gastroenterological Society of Australia. Dr Clark received funding from the National Centre in HIV Epidemiology and Clinical Research (now The Kirby Institute for Infection and Immunity in Society), University of New South Wales, Australia, and the AASLD/LIFER Clinical and Translational Research Fellowship in Liver Diseases Award. Dr Thompson received funding from the Royal Australian College of Physicians. NR 33 TC 24 Z9 24 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1352-0504 J9 J VIRAL HEPATITIS JI J. Viral Hepatitis PD MAY PY 2012 VL 19 IS 5 BP 332 EP 340 DI 10.1111/j.1365-2893.2011.01553.x PG 9 WC Gastroenterology & Hepatology; Infectious Diseases; Virology SC Gastroenterology & Hepatology; Infectious Diseases; Virology GA 925ZH UT WOS:000302800600005 PM 22497812 ER PT J AU Gallagher, TQ Setlur, J Maturo, S Hartnick, CJ AF Gallagher, Thomas Q. Setlur, Jennifer Maturo, Stephen Hartnick, Christopher J. TI Percutaneous transtracheal needle insufflation: A useful emergency airway adjunct simply constructed from common items found on your anesthesia cart SO LARYNGOSCOPE LA English DT Article DE Transtracheal; needle insufflation; pediatric airway; emergency airway AB Using material already available in the operating room, we describe the construction and application of a percutaneous transtracheal needle insufflation device to be used in pediatric airway emergencies. Our technique of percutaneous needle insufflation using common materials found in the operating room can be a helpful adjunct in a time of need. Quickly constructed and at a minimal cost, the device can be just one of the many useful tools found in the otolaryngologist's airway armamentarium. C1 [Gallagher, Thomas Q.] USN, Med Ctr, Dept Otolaryngol, Portsmouth, VA 23708 USA. [Maturo, Stephen] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Boston, MA USA. [Maturo, Stephen] Brooke Army Med Ctr, Dept Otolaryngol, San Antonio, TX USA. RP Gallagher, TQ (reprint author), USN, Med Ctr, Dept Otolaryngol, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA. EM thomas.q.gallagher@med.navy.mil NR 4 TC 3 Z9 3 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD MAY PY 2012 VL 122 IS 5 BP 1178 EP 1180 DI 10.1002/lary.23236 PG 3 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 927XY UT WOS:000302945100043 PM 22447414 ER PT J AU Wu, N Zou, XT Tian, Y Fitek, J Maffeo, M Niezrecki, C Chen, J Wang, XW AF Wu, Nan Zou, Xiaotian Tian, Ye Fitek, John Maffeo, Michael Niezrecki, Christopher Chen, Julie Wang, Xingwei TI An ultra-fast fiber optic pressure sensor for blast event measurements SO MEASUREMENT SCIENCE AND TECHNOLOGY LA English DT Article DE pressure sensor; fiber optic; traumatic brain injury; shock tube ID TRAUMATIC BRAIN-INJURY; SHOCK; WAVE; DIAPHRAGM AB Soldiers who are exposed to explosions are at risk of suffering traumatic brain injury (TBI). Since the causal relationship between a blast and TBI is poorly understood, it is critical to have sensors that can accurately quantify the blast dynamics and resulting wave propagation through a helmet and skull that are imparted onto and inside the brain. To help quantify the cause of TBI, it is important to record transient pressure data during a blast event. However, very few sensors feature the capabilities of tracking the dynamic pressure transients due to the rapid change of the pressure during blast events, while not interfering with the physical material layers or wave propagation. In order to measure the pressure transients efficiently, a pressure sensor should have a high resonant frequency and a high spatial resolution. This paper describes an ultra-fast fiber optic pressure sensor based on the Fabry-Perot principle for the application of measuring the rapid pressure changes in a blast event. A shock tube experiment performed in US Army Natick Soldier Research, Development and Engineering Center has demonstrated that the resonant frequency of the sensor is 4.12 MHz, which is relatively close to the designed theoretical value of 4.113 MHz. Moreover, the experiment illustrated that the sensor has a rise time of 120 ns, which demonstrates that the sensor is capable of observing the dynamics of the pressure transient during a blast event. C1 [Wu, Nan; Tian, Ye; Wang, Xingwei] Univ Massachusetts Lowell, Dept Elect & Comp Engn, Lowell, MA 01854 USA. [Zou, Xiaotian] Univ Massachusetts Lowell, Dept Biomed Engn & Biotechnol, Lowell, MA 01854 USA. [Fitek, John; Maffeo, Michael] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Niezrecki, Christopher; Chen, Julie] Univ Massachusetts Lowell, Dept Mech Engn, Lowell, MA 01854 USA. RP Wu, N (reprint author), Univ Massachusetts Lowell, Dept Elect & Comp Engn, 1 Univ Ave, Lowell, MA 01854 USA. EM xingwei_wang@uml.edu RI Tian, Ye/A-1090-2014; Zou, Xiaotian/J-8657-2013 OI Tian, Ye/0000-0002-0785-1145; FU Army Research Laboratory [W911NF-07-2-0081] FX The authors are grateful for the collaboration with Natick Soldier Research, Development and Engineering Center for sharing the shock tube and the reference pressure sensors. The authors also appreciate the Army Research Laboratory for sponsoring this work (Nanomanufacturing of Multifunctional Sensors Award Number W911NF-07-2-0081). NR 19 TC 9 Z9 9 U1 2 U2 18 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0957-0233 EI 1361-6501 J9 MEAS SCI TECHNOL JI Meas. Sci. Technol. PD MAY PY 2012 VL 23 IS 5 AR 055102 DI 10.1088/0957-0233/23/5/055102 PG 7 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 929CR UT WOS:000303039300016 ER PT J AU Carter, KK Valdes, JJ Bentley, WE AF Carter, Karen K. Valdes, James J. Bentley, William E. TI Pathway engineering via quorum sensing and sRNA riboregulators-Interconnected networks and controllers SO METABOLIC ENGINEERING LA English DT Article DE Quorum sensing; Synthetic biology; Pathway engineering; Metabolic engineering ID CELL-CELL COMMUNICATION; SMALL NONCODING RNAS; ENTEROHEMORRHAGIC ESCHERICHIA-COLI; GENE-EXPRESSION; PSEUDOMONAS-AERUGINOSA; VIBRIO-CHOLERAE; SYNTHETIC BIOLOGY; DIRECTED EVOLUTION; SIGMA-FACTOR; POSITIVE REGULATION AB The advent of genetic engineering has elevated our level of comprehension of cellular processes and functions. A natural progression of these findings is determining not only how these processes function within individual cells but also within a community. Bacterial cells monitor the conditions and microorganisms in their vicinity by producing, releasing and sensing chemical-signaling molecules. When a specific cell-density threshold is reached, a quorum is perceived, gene expression profiles are altered and the community orchestrates activities that are more effective en masse. This communication mechanism, in the language of autoinducers (AI), is referred to as quorum sensing (QS). It has become increasingly evident that while scientists attempt to decipher the intricacies of cellular communication and quorum sensing networks, we must remain conscious of the broader context of how a cell may identify itself in the environment and how this also impacts QS. Importantly, these phenomena span time and length scales by several orders in magnitude. Though the revelation of small RNAs, as both sensing and regulatory elements participating in the quorum sensing cascade, has connected new pieces of the puzzle, it has also added a new tier of uncertainty. The complexity of quorum sensing networks makes resolution of its diverse mechanisms difficult. The ability to design simpler networks with defined, more predictable or even "modular" elements will help elucidate these actions. Because it embraces innovative concepts of biological design accommodating the many length and time scales at play, synthetic biology serves as one of the most promising platforms for describing QS phenomena as well as enabling novel implementation strategies for biotechnological application. (C) 2011 Elsevier Inc. All rights reserved. C1 [Carter, Karen K.; Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Carter, Karen K.; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. [Valdes, James J.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM bentley@eng.umd.edu FU DTRA [BO08SPO008]; NSF [EFRI 0735987] FX The authors appreciate partial funding of this work from DTRA (#BO08SPO008) and NSF (EFRI 0735987). NR 122 TC 15 Z9 16 U1 0 U2 34 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1096-7176 EI 1096-7184 J9 METAB ENG JI Metab. Eng. PD MAY PY 2012 VL 14 IS 3 BP 281 EP 288 DI 10.1016/j.ymben.2011.11.006 PG 8 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 927AD UT WOS:000302876000012 PM 22155614 ER PT J AU Nestler, JM Pompeu, PS Goodwin, RA Smith, DL Silva, LGM Baigun, CRM Oldani, NO AF Nestler, J. M. Pompeu, P. S. Goodwin, R. A. Smith, D. L. Silva, L. G. M. Baigun, C. R. M. Oldani, N. O. TI THE RIVER MACHINE: A TEMPLATE FOR FISH MOVEMENT AND HABITAT, FLUVIAL GEOMORPHOLOGY, FLUID DYNAMICS AND BIOGEOCHEMICAL CYCLING SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE hydro-geomorphology; river theory; fish migration; biogeochemical cycling; large river ecology; large river fish requirements; large river fish habitat ID SAO-FRANCISCO RIVER; PARANA RIVER; PROCHILODUS-ARGENTEUS; HYDROLOGIC ALTERATION; ARTISANAL FISHERIES; ORGANIC-MATTER; STREAM ECOLOGY; SPECIES TRAITS; PATCH DYNAMICS; LOTIC SYSTEMS AB The dynamics of many large floodplain rivers are dominated by the flood pulse. The high kinetic energy of the erosive flows associated with the flood pulse forms and reforms the river channel. In general, the flood pulse supports the immense abundance and diversity of river life by transporting nutrients and organic matter into backwaters in spring, supporting primary and secondary production during the summer and redistributing these products to channels as water levels recede. Both North American and South American fluvial-dependent large river fishes exhibit complex, system-level longitudinal and/or lateral movements across life stages that allow them to exploit flood pulse-driven spatial heterogeneity and seasonal connectivity to feed, reproduce and avoid harsh conditions. We argue that two hydraulic variables, the magnitudes of velocity and the spatial velocity gradient, are necessary and sufficient to both understand fish hydro-navigation as well as explain patterns in biogeochemistry and fluvial geomorphology and thereby create a new conceptual framework for large floodplain rivers integrating fluid dynamics, channel morphology, biogeochemical cycling and important elements of fish ecology. We illustrate the framework using summary data from the Sao Francisco River, Brazil that contains sub-basins possessing different levels of impact and also from the lower Parana River (Argentina) where natural processes can still be studied. We believe the framework is an important element of large river restoration because it directly links the unique physical and chemical processes of large floodplain rivers to life requirements important to fishes and other biota. Copyright (C) 2011 John Wiley & Sons, Ltd. C1 [Nestler, J. M.] Univ Iowa, IIHR Hydrosci & Engn, Stanley Hydraul Lab 100, Iowa City, IA 52242 USA. [Pompeu, P. S.] Univ Fed Lavras, Dept Biol, Lavras, MG, Brazil. [Goodwin, R. A.] USA, Environm Lab, Army Engineer Res & Dev Ctr, CENWP EC HD, Portland, OR USA. [Smith, D. L.] USA, Environm Lab, Engineer Res & Dev Ctr, CEERD EP W, Vicksburg, MS USA. [Silva, L. G. M.] Univ Sao Joao del Rei, Ouro Branco, MG, Brazil. [Baigun, C. R. M.] IIB INTECH, Chascomus, Argentina. [Oldani, N. O.] Inst Desarrollo Tecnol Ind Quim INTEC CERIDE, Santa Fe, Argentina. RP Nestler, JM (reprint author), Univ Iowa, IIHR Hydrosci & Engn, Stanley Hydraul Lab 100, Iowa City, IA 52242 USA. EM john.m.nestler@gmail.com RI Pompeu, Paulo/F-6696-2012; M. Silva, Luiz G./O-9841-2016 OI M. Silva, Luiz G./0000-0002-2329-5601 FU Leverhulme Trust; FONCYT (Argentina) [PICT 01849] FX We gratefully acknowledge the many colleagues who endured endless discussions on how environmental fluid dynamics could illuminate how large river fishes relate to their physical environment. In particular, we thank Mike Davis, Larry Weber, David Galat and Robert Hrabik for their patience and input. We thank the Leverhulme Trust for sponsoring the conferences where the ideas in this manuscript evolved over a period of 3 years. This research was partially supported by PICT 01849 FONCYT (Argentina). We gratefully acknowledge the helpful comments of two anonymous reviewers. This manuscript is the basis of a presentation given at the International Conference on the Status and Future of the World's Large River Conference in Vienna, Austria from 18 to 21 April 2011. NR 92 TC 8 Z9 10 U1 2 U2 47 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1535-1459 EI 1535-1467 J9 RIVER RES APPL JI River Res. Appl. PD MAY PY 2012 VL 28 IS 4 SI SI BP 490 EP 503 DI 10.1002/rra.1567 PG 14 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 927UY UT WOS:000302937000008 ER PT J AU Che, MM Song, J Oguntayo, S Doctor, BP Rezk, P Perkins, MW Sciuto, AM Nambiar, MP AF Che, Magnus M. Song, Jian Oguntayo, Samuel Doctor, Bhupendra P. Rezk, Peter Perkins, Michael W. Sciuto, Alfred M. Nambiar, Madhusoodana P. TI Treatment with endotracheal therapeutics after sarin microinstillation inhalation exposure increases blood cholinesterase levels in guinea pigs SO TOXICOLOGY MECHANISMS AND METHODS LA English DT Article DE Acetylcholinesterase; chemical warfare nerve agents; inhalation exposure; respiratory toxicity; respiratory therapeutics ID ACUTE LUNG INJURY; NERVE AGENT-VX; NONNEURONAL CHOLINERGIC SYSTEM; NOSE-ONLY EXPOSURE; ACETYLCHOLINESTERASE ACTIVITY; SOMAN STEREOISOMERS; INDUCED SEIZURES; ANIMAL-MODELS; TOXICITY; ATROPINE AB Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities were measured in the blood and tissues of animals that are treated with a number of endotracheally aerosolized therapeutics for protection against inhalation toxicity to sarin. Therapeutics included, aerosolized atropine methyl bromide (AMB), scopolamine or combination of AMB with salbutamol, sphingosine 1-phosphate, keratinocyte growth factor, adenosine A1 receptor antisense oligonucleotide (EPI2010), 2,3-diacetyloxybenzoic acid (2,3 DABA), oxycyte, and survanta. Guinea pigs exposed to 677.4 mg/m(3) or 846.5 mg/m(3) (1.2 LCt(50)) sarin for 4 min using a microinstillation inhalation exposure technique and treated 1 min later with the aerosolized therapeutics. Treatment with all therapeutics significantly increased the survival rate with no convulsions throughout the 24 h study period. Blood AChE activity determined using acetylthiocholine as substrate showed 20% activity remaining in sarin-exposed animals compare to controls. In aerosolized AMB and scopolamine-treated animals the remaining AChE activity was significantly higher (45-60%) compared to sarin-exposed animals (p < 0.05). Similarly, treatment with all the combination therapeutics resulted in significant increase in blood AChE activity in comparison to sarin-exposed animals although the increases varied between treatments (p < 0.05). BChE activity was increased after treatment with aerosolized therapeutics but was lesser in magnitude compared to AChE activity changes. Various tissues showed elevated AChE activity after therapeutic treatment of sarin-exposed animals. Increased AChE and BChE activities in animals treated with nasal therapeutics suggest that enhanced breathing and reduced respiratory toxicity/lung injury possibly contribute to rapid normalization of chemical warfare nerve agent inhibited cholinesterases. C1 [Che, Magnus M.; Song, Jian; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. [Rezk, Peter; Perkins, Michael W.; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU National Institutes of Environmental Health Sciences/National Institutes of Health (NIEHS/NIH) [5U01ES015677] FX The project described was supported by (Grant Number 5U01ES015677) National Institutes of Environmental Health Sciences/National Institutes of Health (NIEHS/NIH) and managed by the Geneva Foundation, Lakewood, WA. Its contents, opinions and assertions contained herein are private views of the authors and are not to be construed as official or reflecting the views of the NIEHS/NIH, Department of the Army or the Department of Defense. NR 60 TC 0 Z9 0 U1 0 U2 4 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1537-6516 J9 TOXICOL MECH METHOD JI Toxicol. Mech. Methods PD MAY PY 2012 VL 22 IS 4 BP 250 EP 259 DI 10.3109/15376516.2011.639817 PG 10 WC Toxicology SC Toxicology GA 927JL UT WOS:000302903400002 PM 22145985 ER PT J AU Goswami, R Nightingale, JR Duperre, JA Lim, MS Dawson, JM Timperman, A Korakakis, D Hornak, LA AF Goswami, Rohit Nightingale, Joshua R. Duperre, Joseph A., III Lim, Min S. Dawson, Jeremy Michael Timperman, Aaron Korakakis, Dimitris Hornak, Lawrence A. TI Surface Loading Sensitivity Characterization of a Resonant Planar Optical Waveguide Stack SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE Evanescent wave sensors; optical sensitivity analysis; planar waveguide; thin film devices ID ASSISTED DEPOSITION; ALUMINA; ADSORPTION; SUCROSE AB Detuning of a coupled planar waveguide pair through surface loading of the top waveguide that is in contact with the analyte serves as a transducer for a Stacked Planar Affinity-Regulated Resonant Optical Waveguide (SPARROW) sensor. Here we investigate the surface loading detection sensitivity of a SPARROW transducer composed of a stack of two planar alumina waveguides grown using ion beam assisted e-beam deposition. Using a sucrose analyte solution introduced to the stack surface in a poly-di-methyl-siloxane (PDMS) microfluidic channel, the change in optical output power through the coupled waveguide pair as a function of sucrose analyte solution concentration was experimentally determined. Based on the analyte in the evanescent field penetration depth volume, the effective minimum detectable surface loading of the stack was determined to be 20 pg/mm(2) with a bulk index sensitivity of 5.6 x 10(-4) refractive index units (RIU) for this stack configuration and experimental setup. C1 [Goswami, Rohit; Nightingale, Joshua R.; Duperre, Joseph A., III; Dawson, Jeremy Michael; Korakakis, Dimitris; Hornak, Lawrence A.] W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26505 USA. [Lim, Min S.] Slippery Rock Univ, Slippery Rock, PA 16057 USA. [Timperman, Aaron] Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Hornak, Lawrence A.] Natl Sci Fdn, Arlington, VA 22230 USA. RP Goswami, R (reprint author), W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26505 USA. EM rgoswami@mix.wvu.edu; joshnightingale@gmail.com; joseph.duperre@gmail.com; min.lim@sru.edu; jeremy.dawson@mail.wvu.edu; atimperm@wvu.edu; Dimitris.Korakakis@mail.wvu.edu; lahornak@mail.wvu.edu FU ONR [N00014-03-1-0815]; NSF RII [EPS 0554328]; NSF IPA; WVU Research Corporation; WV EPSCoR Office FX Manuscript received September 26, 2011; revised January 24, 2012; accepted February 11, 2012. Date of publication February 16, 2012; date of current version April 11, 2012. This work was supported in part by the ONR under Grant N00014-03-1-0815, in part by the NSF RII under Grant EPS 0554328, in part by the NSF IPA Independent Research and Development Program, and in part by the WVU Research Corporation and WV EPSCoR Office. NR 12 TC 0 Z9 0 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD MAY 1 PY 2012 VL 24 IS 9 BP 778 EP 780 DI 10.1109/LPT.2012.2188384 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 924ZM UT WOS:000302729800008 ER PT J AU Yadava, A Nurmukhambetova, S Pichugin, AV Lumsden, JM AF Yadava, Anjali Nurmukhambetova, Saule Pichugin, Alexander V. Lumsden, Joanne M. TI Cross-Species Immunity Following Immunization With a Circumsporozoite Protein-Based Vaccine for Malaria SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PLASMODIUM-FALCIPARUM SPOROZOITES; SYNTHETIC PEPTIDES; HEPARAN-SULFATE; CELL INVASION; REGION-II; IN-VIVO; ANTIBODIES; EPITOPE; TRIAL; RTS,S/AS02A AB Malaria continues to be a major public health concern, and there are concerted efforts to eliminate it. The quest for a vaccine remains a top priority, and vaccines based on the circumsporozoite protein (CSP) are among the lead candidates, with the RTS, S vaccine currently undergoing phase 3 testing in Africa. Previous studies have reported anti-CSP antibody-mediated enhancement of in vitro invasion of homologous sporozoites. This effect has been shown to be concentration dependent; high-level antibodies are inhibitory, whereas low-level antibodies lead to enhancement of invasion. Nondominant shared epitopes may lead to the generation of low titers of cross-reactive antibodies that may prove to be detrimental. We report cross-species recognition of Plasmodium falciparum and Plasmodium berghei sporozoites by anti-Plasmodium vivax CSP serum samples. In addition, we report that vaccination of mice with VMP001, a P. vivax CSP vaccine candidate, reduces, not enhances, P. berghei infection in mice. C1 [Yadava, Anjali; Nurmukhambetova, Saule; Pichugin, Alexander V.; Lumsden, Joanne M.] Walter Reed Army Inst Res, US Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. RP Yadava, A (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM anjali.yadava@us.army.mil OI Pichugin, Alexander/0000-0002-2577-7284 FU United States Army Medical Materiel Development Activity; Military Infectious Diseases Research Program (Fort Detrick, Maryland) FX This work was supported by the United States Army Medical Materiel Development Activity and the Military Infectious Diseases Research Program (Fort Detrick, Maryland). NR 31 TC 7 Z9 7 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY 1 PY 2012 VL 205 IS 9 BP 1456 EP 1463 DI 10.1093/infdis/jis220 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 921QI UT WOS:000302491800017 PM 22457289 ER PT J AU Burke, RL Kronmann, KC Daniels, CC Meyers, M Byarugaba, DK Dueger, E Klein, TA Evans, BP Vest, KG AF Burke, R. L. Kronmann, K. C. Daniels, C. C. Meyers, M. Byarugaba, D. K. Dueger, E. Klein, T. A. Evans, B. P. Vest, K. G. TI A Review of Zoonotic Disease Surveillance Supported by the Armed Forces Health Surveillance Center SO ZOONOSES AND PUBLIC HEALTH LA English DT Review DE Zoonotic; surveillance; US military; human-animal interface ID REPUBLIC-OF-KOREA; BRIDGES TRAINING AREA; INFLUENZA-A VIRUS; GYEONGGI PROVINCE; SMALL MAMMALS; SEROLOGICAL SURVEILLANCE; INFECTION SURVEILLANCE; COXIELLA-BURNETII; MURINE TYPHUS; SCRUB TYPHUS AB The Armed Forces Health Surveillance Center (AFHSC), Division of Global Emerging Infections Surveillance and Response System conducts disease surveillance through a global network of US Department of Defense research laboratories and partnerships with foreign ministries of agriculture, health and livestock development in over 90 countries worldwide. In 2010, AFHSC supported zoonosis survey efforts were organized into four main categories: (i) development of field assays for animal disease surveillance during deployments and in resource limited environments, (ii) determining zoonotic disease prevalence in high-contact species which may serve as important reservoirs of diseases and sources of transmission, (iii) surveillance in high-risk human populations which are more likely to become exposed and subsequently infected with zoonotic pathogens and (iv) surveillance at the humananimal interface examining zoonotic disease prevalence and transmission within and between human and animal populations. These efforts have aided in the detection, identification and quantification of the burden of zoonotic diseases such as anthrax, brucellosis, Crimean Congo haemorrhagic fever, dengue fever, Hantaan virus, influenza, Lassa fever, leptospirosis, melioidosis, Q fever, Rift Valley fever, sandfly fever Sicilian virus, sandfly fever Naples virus, tuberculosis and West Nile virus, which are of military and public health importance. Future zoonotic surveillance efforts will seek to develop local capacity for zoonotic surveillance focusing on high risk populations at the humananimal interface. C1 [Burke, R. L.; Vest, K. G.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Kronmann, K. C.] Adjacent Abbassia Fever Hosp, Naval Med Res Unit 3, Cairo, Egypt. [Daniels, C. C.] DoD Vet Food Anal & Diagnost Lab, San Antonio, TX USA. [Meyers, M.; Evans, B. P.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Byarugaba, D. K.] Makerere Univ, Sch Vet Med, Kampala, Uganda. [Dueger, E.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Dueger, E.] Global Dis Detect Reg Ctr, Naval Med Res Unit 3, Cairo, Egypt. [Klein, T. A.] US Army Yongsan Garrison Force Hlth Protect & Pre, Seoul, South Korea. RP Burke, RL (reprint author), Armed Forces Hlth Surveillance Ctr, 11800 Tech Rd,Suite 200, Silver Spring, MD 20904 USA. EM ronald.l.burke@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU US Department of Defense FX We thank Dr Elisabeth Fichet-Calvet for her expert knowledge and advice on studying rodents in West Africa, Dr Lisa Hensley for providing expertise on testing for Lassa virus, and Ms Shirley Cameron Nimo Paintsil for her tireless work in developing and executing protocols for studies in Ghana. We also thank Dr Heung-Chul Kim, 65th Medical Brigade, Dr Jin Won Song, Korea University, and Dr Joon-Seok Chae, Seoul National University, for their technical support with the Korean surveillance. Funding for these efforts was provided by the US Department of Defense. NR 58 TC 6 Z9 7 U1 3 U2 35 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1863-1959 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD MAY PY 2012 VL 59 IS 3 BP 164 EP 175 DI 10.1111/j.1863-2378.2011.01440.x PG 12 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA 923KX UT WOS:000302619300002 PM 22128834 ER PT J AU Gehrich, AP Hill, MJ McWilliams, GDE Larsen, W McCartin, T AF Gehrich, Alan Paul Hill, Micah J. McWilliams, Grant D. E. Larsen, Wilma McCartin, Tamarin TI Comparison of Urodynamic Volume Measurements Using Room and Body Temperature Saline: A Double-Blinded Randomized Crossover Study Design SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE urodynamic studies; idiopathic detrusor overactivity; fluid temperature; reproducibility; bladder sensation AB Introduction: Urodynamic studies, routinely performed in women with lower urinary tract symptoms, have a large impact on clinical decision making. Unfortunately, these studies are insensitive in reproducing idiopathic detrusor overactivity (IDO). We set out to examine whether serial cystometry with different distending fluid temperatures could better reproduce symptoms. Methods: Eighty-six women were enrolled in a double-blinded, randomized, crossover study. Two cystometries were performed in series, starting with either body temperature fluid (BTF) or room temperature fluid (RTF) and then repeating cystometry with the other temperature fluid. Primary outcomes included first sensation, first urge, and maximum cystometric capacity. Secondary outcomes included subjective sensation of bladder discomfort and the incidence of IDO. Results: In aggregate, the temperature of the fluid did not affect volumes of bladder sensation. There were no differences in self-reported bladder irritation or IDO between the different temperature fluids. There was a significant carryover effect with BTF. BTF administered first reached sensory thresholds at lower volumes than when it was administered second after RTF. Room temperature fluid cystometry showed no statistical difference in volume between first fill and second fill. Idiopathic detrusor overactivity contractions were seen in 9% of studies and were not affected by period or temperature. Conclusions: These data suggest that BTF and RTF independently do not affect bladder sensory thresholds. The periodicity in combination with varying fluid temperature is of greater impact. This study documents that changes in temperature of the distending fluid from BTF to RTF or vice versa likely do not provoke IDO contractions. C1 [Gehrich, Alan Paul; Hill, Micah J.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [McWilliams, Grant D. E.] Basset Army Community Hosp, Fairbanks, AK USA. [Larsen, Wilma] Scott & White Hosp, Temple, TX USA. [McCartin, Tamarin] Maui Community Hosp, Kahalui, HI USA. RP Gehrich, AP (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. EM alan.gehrich@us.army.mil NR 21 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD MAY-JUN PY 2012 VL 18 IS 3 BP 170 EP 174 DI 10.1097/SPV.0b013e3182532160 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35XI UT WOS:000209178100010 PM 22543771 ER PT J AU Odierno, RT AF Odierno, Raymond T. TI The US Army in a Time of Transition Building a Flexible Force SO FOREIGN AFFAIRS LA English DT Editorial Material C1 USA, Washington, DC 20310 USA. RP Odierno, RT (reprint author), USA, Washington, DC 20310 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU COUNCIL FOREIGN RELAT IONS INC PI NEW YORK PA HAROLD PRATT HOUSE, 58 E 68TH ST, NEW YORK, NY 10065 USA SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD MAY-JUN PY 2012 VL 91 IS 3 BP 7 EP 11 PG 5 WC International Relations SC International Relations GA 145NJ UT WOS:000319023400002 ER PT J AU Natesan, S Zamora, DO Suggs, LJ Christy, RJ AF Natesan, Shanmugasundaram Zamora, David O. Suggs, Laura J. Christy, Robert J. TI Engineering a Bilayered Hydrogel to Control ASC Differentiation SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS LA English DT Article DE Bioengineering; Issue 63; Biomedical Engineering; Tissue Engineering; chitosan; microspheres; collagen; hydrogel; PEG fibrin; cell delivery; adipose-derived stem cells; ASC; CSM AB Natural polymers over the years have gained more importance because of their host biocompatibility and ability to interact with cells in vitro and in vivo. An area of research that holds promise in regenerative medicine is the combinatorial use of novel biomaterials and stem cells. A fundamental strategy in the field of tissue engineering is the use of three-dimensional scaffold (e.g., decellularized extracellular matrix, hydrogels, micro/nano particles) for directing cell function. This technology has evolved from the discovery that cells need a substrate upon which they can adhere, proliferate, and express their differentiated cellular phenotype and function(2-3). More recently, it has also been determined that cells not only use these substrates for adherence, but also interact and take cues from the matrix substrate (e.g., extracellular matrix, ECM)(4). Therefore, the cells and scaffolds have a reciprocal connection that serves to control tissue development, organization, and ultimate function. Adipose-derived stem cells (ASCs) are mesenchymal, non-hematopoetic stem cells present in adipose tissue that can exhibit multi-lineage differentiation and serve as a readily available source of cells (i.e. pre-vascular endothelia and pericytes). Our hypothesis is that adipose-derived stem cells can be directed toward differing phenotypes simultaneously by simply co-culturing them in bilayered matrices(1). Our laboratory is focused on dermal wound healing. To this end, we created a single composite matrix from the natural biomaterials, fibrin, collagen, and chitosan that can mimic the characteristics and functions of a dermal-specific wound healing ECM environment. C1 [Natesan, Shanmugasundaram; Zamora, David O.; Christy, Robert J.] US Army Inst Surg Res, Dept Extrem Trauma Res & Regenerat Med, Houston, TX 78234 USA. [Suggs, Laura J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. RP Christy, RJ (reprint author), US Army Inst Surg Res, Dept Extrem Trauma Res & Regenerat Med, Houston, TX 78234 USA. EM Robert.Christy@us.army.mil OI Zamora, David/0000-0002-7003-5933; Natesan, Shanmugasundaram/0000-0003-4213-3111 FU Pittsburgh Tissue Engineering Initiative; Geneva Foundation FX S.N. was supported by a Postdoctoral Fellowship Grant from the Pittsburgh Tissue Engineering Initiative. D.O.Z. is supported by a grant awarded from The Geneva Foundation. NR 11 TC 1 Z9 1 U1 3 U2 14 PU JOURNAL OF VISUALIZED EXPERIMENTS PI CAMBRIDGE PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA SN 1940-087X J9 JOVE-J VIS EXP JI J. Vis. Exp. PD MAY PY 2012 IS 63 AR UNSP e3953 DI 10.3791/3953 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V36PH UT WOS:000209223000036 PM 22664758 ER PT J AU Ringelberg, DB Foley, KL Reynolds, CM AF Ringelberg, D. B. Foley, K. L. Reynolds, C. M. TI Electrogenic capacity and community composition of anodic biofilms in soil-based bioelectrochemical systems (vol 90, pg 1805, 2011) SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY LA English DT Correction C1 [Ringelberg, D. B.] USA, ERDC CRREL, Hanover, NH 03755 USA. [Ringelberg, D. B.; Foley, K. L.; Reynolds, C. M.] USA, Cold Reg Res & Engn Ctr, Hanover, NH USA. RP Ringelberg, DB (reprint author), USA, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM david.b.ringelberg@usace.army.mil NR 1 TC 0 Z9 0 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0175-7598 J9 APPL MICROBIOL BIOT JI Appl. Microbiol. Biotechnol. PD MAY PY 2012 VL 94 IS 3 BP 839 EP 839 DI 10.1007/s00253-012-3972-9 PG 1 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 918XB UT WOS:000302283700025 ER PT J AU Yang, J Kerwin, SM Bowman, PD Stavchansky, S AF Yang, John Kerwin, Sean M. Bowman, Phillip D. Stavchansky, Salomon TI Stability of Caffeic Acid Phenethyl Amide (CAPA) in Rat Plasma SO BIOMEDICAL CHROMATOGRAPHY LA English DT Article DE Caffeic Acid Phenethyl Amide; Caffeic Acid Phenethyl Ester; Plasma Stability; Endothelial Cells; HPLC ID ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; ESTER CAPE; CELLS; EXPRESSION; PROPOLIS; ACTIVATION; INHIBITOR; APOPTOSIS AB A validated C18 reverse-phase HPLC method with UV detection at 320 nm was developed and used for the stability evaluation of caffeic acid phenethyl amide (CAPA) and caffeic acid phenethyl ester (CAPE) in rat plasma. CAPA is the amide derivative of CAPE, a naturally occurring polyphenolic compound that has been found to be active in a variety of biological pathways. CAPA has been shown to protect endothelial cells against hydrogen peroxide-induced oxidative stress to a similar degree to CAPE. CAPE has been reported to be rapidly hydrolyzed in rat plasma via esterase enzymes. CAPA is expected to display a longer half-life than CAPE by avoiding hydrolysis via plasma esterases. The stability of CAPA and CAPE in rat plasma was investigated at three temperatures. The half-lives for CAPA were found to be 41.5, 10 and 0.82 h at 25, 37 and 60 degrees C, respectively. The half-lives for CAPE were found to be 1.95, 0.35 and 0.13 h at 4, 25 and 37 degrees C, respectively. The energy of activation was found to be 22.1 kcal/mol for CAPA and 14.1 kcal/mol for CAPE. A more stable compound could potentially extend the beneficial effects of CAPE. Copyright (c) 2011 John Wiley & Sons, Ltd. C1 [Yang, John; Stavchansky, Salomon] Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. RP Stavchansky, S (reprint author), Univ Texas Austin, Coll Pharm, Div Pharmaceut, Austin, TX 78712 USA. EM stavchansky@mail.utexas.edu OI Kerwin, Sean/0000-0001-8432-6558 NR 19 TC 9 Z9 9 U1 0 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-3879 J9 BIOMED CHROMATOGR JI Biomed. Chromatogr. PD MAY PY 2012 VL 26 IS 5 BP 594 EP 598 DI 10.1002/bmc.1702 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 919TD UT WOS:000302350800008 PM 21915890 ER PT J AU Teranishi, K Scultetus, A Haque, A Stern, S Philbin, N Rice, J Johnson, T Auker, C McCarron, R Freilich, D Arnaud, F AF Teranishi, Kohsuke Scultetus, Anke Haque, Ashraful Stern, Susan Philbin, Nora Rice, Jennifer Johnson, Todd Auker, Charles McCarron, Richard Freilich, Daniel Arnaud, Francoise TI Traumatic brain injury and severe uncontrolled haemorrhage with short delay pre-hospital resuscitation in a swine model SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Haemoglobin-based oxygen carrier; Polytrauma; Haemorrhagic shock; Traumatic brain injury; Resuscitation ID CEREBRAL BLOOD-FLOW; POLYMERIZED HEMOGLOBIN HBOC-201; CARRYING SOLUTION HBOC-201; INTRACRANIAL-PRESSURE; OXYGEN CARRIER; VOLUME RESUSCITATION; FLUID RESUSCITATION; PORCINE MODEL; LIVER-INJURY; HEAD-INJURY AB Introduction: Unavailability of blood (and oxygen delivery) for pre-hospital resuscitation in haemorrhagic shock patients are major problems, supporting the importance for novel resuscitation strategies. In a combined polytrauma model of uncontrolled haemorrhage and traumatic brain injury (TBI) in swine, we investigated if pre-hospital administration of the haemoglobin based oxygen carrier HBOC-201 will improve tissue oxygenation and physiologic parameters compared to Lactated Ringer's (LR) solution. Materials and methods: Anaesthetised Yorkshire swine underwent fluid-percussion TBI and Grade III liver laceration. During a 30-min pre-hospital phase, the animals were resuscitated with a single infusion of HBOC-201, LR solution, or nothing (NON). Upon hospital arrival, the animals were given blood or normal saline as needed. Surviving animals were euthanised 6 h post-injury. Cerebral blood flow was measured by microsphere injection, and pathology was assessed by gross observation and immunohistochemical analysis. Results: Mean TBI force (2.4 +/- 0.1 atm) (means +/- standard error of the mean) and blood loss (22.5 +/- 1.7 mL/kg) were similar between groups. Survival at the 6 h endpoint was similar in all groups (similar to 50%). Cerebral perfusion pressure (CPP) and brain tissue oxygen tension were significantly greater in HBOC-201 as compared with LR animals (p < 0.005). Mean arterial pressure (MAP) and mean pulmonary artery pressure (MPAP) were not significantly different amongst groups. Blood transfusion requirements were delayed in HBOC-201 animals. Animals treated with HBOC-201 or LR showed no immunohistopathological differences in glial fibrillary acidic protein (GFAP) and microtubule-associated protein 2 (MAP-2). Severity of subarachnoid and intraparenchymal haemorrhages were similar for HBOC and LR groups. Conclusion: In this polytrauma swine model of uncontrolled haemorrhage and TBI with a 30-min delay to hospital arrival, pre-hospital resuscitation with one bolus of HBOC-201 indicated short term benefits in systemic and cerebrovascular physiological parameters. True clinical benefits of this strategy need to be confirmed on TBI and haemorrhagic shock patients. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Arnaud, Francoise] USN, Med Res Ctr, Operat & Undersea Med Directorate, NeuroTrauma Dept, Silver Spring, MD 20910 USA. [Teranishi, Kohsuke] Juntendo Univ, Sch Med, Dept Neurosurg, Tokyo 113, Japan. [Scultetus, Anke; McCarron, Richard; Freilich, Daniel; Arnaud, Francoise] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Stern, Susan] Univ Washington, Dept Emergency, Seattle, WA 98195 USA. [Johnson, Todd] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA. RP Arnaud, F (reprint author), USN, Med Res Ctr, Operat & Undersea Med Directorate, NeuroTrauma Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Francoise.Arnaud@med.navy.mil FU Naval Medical Research Center, Silver Spring, MD; DoD Work Unit [604771N.9737.001.A0315] FX This work was performed at Naval Medical Research Center, Silver Spring, MD and was supported by funding from DoD Work Unit No. 604771N.9737.001.A0315. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U. S. Government. NR 42 TC 10 Z9 11 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD MAY PY 2012 VL 43 IS 5 BP 585 EP 593 DI 10.1016/j.injury.2010.09.042 PG 9 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 918RC UT WOS:000302267100008 PM 21036354 ER PT J AU Moon-Massat, P Scultetus, A Arnaud, F Brown, A Haque, A Saha, B Kim, B Sagini, E McGwin, G Auker, C McCarron, R Freilich, D AF Moon-Massat, Paula Scultetus, Anke Arnaud, Francoise Brown, Ammon Haque, Ashraful Saha, Biswajit Kim, Bobby Sagini, Eileen McGwin, Gerald, Jr. Auker, Charles McCarron, Richard Freilich, Daniel TI The effect HBOC-201 and sodium nitrite resuscitation after uncontrolled haemorrhagic shock in swine SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED LA English DT Article DE Blood substitute; Emergency medicine; Haemorrhagic shock; HBOC; Nitrite; Resuscitation; Oxygen therapeutic; Transfusion; Vasoactivity ID BOVINE POLYMERIZED HEMOGLOBIN; OXYGEN CARRIER; DELAYED EVACUATION; DEFINITIVE CARE; OXIDE; VASODILATION; DEOXYHEMOGLOBIN; REDUCTION; TOLERANCE; HYPOXIA AB Background: Development of Haemoglobin-based oxygen carriers (HBOCs) as blood substitutes has reached an impasse due to clinically adverse outcomes attributed to vasoconstriction secondary to nitric oxide (NO) scavenging. Studies suggest haemoglobin exhibits nitrite reductase activity that generates NO and N2O3; harnessing this property may offset NO scavenging. Therefore, the effects of concomitantly infusing sodium nitrite (NaNO2) with HBOC-201 were investigated. Methods: Swine underwent uncontrolled liver haemorrhage before receiving up to three 10 min 10 ml/kg infusions of HBOC-201 (HBOC) with or without concurrent NaNO2 (5.4 mu mol/kg [LD NaNO2] or 10.8 mu mol/kg [HD NaNO2]) or 6% Hetastarch (HEX) with or without HD NaNO2 during "prehospital'' resuscitation (15, 30 and 45 min after injury). Definitive surgical care occurred at 75 min; anaesthetic recovery at 120 min. Animals were euthanised at 72 h. Results: NaNO2 temporarily reduced systemic and pulmonary blood pressure increases from HBOC in a dose-dependent fashion. There was no significant effect between groups in indices of tissue oxygenation or survival. Adverse clinical signs requiring humane euthanasia occurred with highest frequency after HBOC + HD NaNO2 (3 of 4 pigs) and HBOC + LD NaNO2 (2 of 4 pigs). Gross evidence of pulmonary congestion was observed in 5 of 8 swine receiving a HBOC and NaNO2 combination compared to 1 of 16 swine receiving HBOC alone, HEX alone, or HEX + NaNO2. Gross lesions correlated with histological evidence of pulmonary oedema and congestion, and in 2 of 4 HBOC + HD NaNO2 pigs, pulmonary fibrin thrombi also were found. No other pig had similar evidence of thrombi. Asymmetric pre-resuscitation cardiac index was a potential confounder. Conclusions: A significant interaction between NaNO2 and HBOC-201 ameliorated HBOC-201 vasoconstrictive effects, consistent with HBOC possessing a nitrite reductase activity that generates vasodilator NO equivalents. Results were relatively equivalent in survival and markers of tissue oxygenation. The highest dose of NaNO2 was the most effective in reducing HBOC-associated pulmonary and systemic vasoactivity but also with the highest incidence of adverse events. In this model, the transient nature of NaNO2 in offsetting HBOC-201 vasoconstriction makes it less clinically promising than anticipated and the combination of NaNO2 and HBOC appear to increase the risk of pulmonary complications in a dose-dependent fashion independently of haemodilutional effects on haemostatic components. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Moon-Massat, Paula; Scultetus, Anke; Arnaud, Francoise; Haque, Ashraful; Saha, Biswajit; Kim, Bobby; Sagini, Eileen; Auker, Charles; McCarron, Richard; Freilich, Daniel] NMRC, Neurotrauma Dept, Silver Spring, MD 20910 USA. [Scultetus, Anke; Arnaud, Francoise; Freilich, Daniel] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Brown, Ammon] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. [McGwin, Gerald, Jr.] Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA. [Freilich, Daniel] Natl Naval Med Ctr, Infect Dis Serv, Bethesda, MD USA. [Auker, Charles] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Auker, Charles] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. RP Moon-Massat, P (reprint author), NMRC, Neurotrauma Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM paula.moon-massat@med.navy.mil FU work unit number BUMED [604771N.9737.001. A0315]; WRAIR Department of Veterinary Surgery FX This work was supported by funded by work unit number BUMED congressionally funded work unit # 604771N.9737.001. A0315.; The authors thank Noemy Carballo and Jean-Michel Arthus for their valuable contributions in the animal laboratory; Sarah Michaud, Mike Hammet and Roli Pessu for their valuable contributions in the haematology laboratory; and the WRAIR Department of Veterinary Surgery for their valuable support of the animal surgeries; and Stephen Ahlers, PhD, Naval Medical Research Center, and David Burris, MD, FACS, Uniformed Services University of the Health Sciences, for valuable scientific critique. The authors thank Mark Gladwin, MD, PhD and Nicolaas Raat, University of Pittsburgh School of Medicine, Pittsburgh, PA for analysing the blood samples for nitrite concentrations and for invaluable discussions on nitrite physiology. NR 27 TC 8 Z9 8 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0020-1383 J9 INJURY JI Injury-Int. J. Care Inj. PD MAY PY 2012 VL 43 IS 5 BP 638 EP 647 DI 10.1016/j.injury.2010.10.013 PG 10 WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery GA 918RC UT WOS:000302267100017 PM 21094491 ER PT J AU Wolfenstine, J Sakamoto, J Allen, JL AF Wolfenstine, J. Sakamoto, J. Allen, J. L. TI Electron microscopy characterization of hot-pressed Al substituted Li7La3Zr2O12 SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID LITHIUM ION CONDUCTION; SOLID-ELECTROLYTE; GARNET AB Hot-pressing was used to prepare a dense (97% relative density) cubic Al substituted Li7La3Zr2O12 material at temperatures lower than typically used for solid-state and/or liquid phase sintering. Electron microscopy analysis revealed equiaxed grains, grain boundaries, and triple junctions free of amorphous and second phases and no Al segregation at grain boundaries. These results suggest that Al2O3 and/or Al cannot act as a sintering aid by reducing grain boundary mobility. If Al2O3 acts as a sintering aid its main function is to enter the lattice as Al to increase the point defect concentration of the slowest moving species. C1 [Wolfenstine, J.; Allen, J. L.] RDRL SED C, Army Res Lab, Adelphi, MD 20783 USA. [Sakamoto, J.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. RP Wolfenstine, J (reprint author), RDRL SED C, Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Jeffrey.b.wolfenstine.civ@mail.mil FU U. S. Army Research Laboratory (ARL); U.S. Army Research Office (ARO); Maryland NanoCenter and its Nanoscale Imaging Spectroscopy and Properties Laboratory; NSF as a MRSEC Shared Experimental Facility FX JW and JAL would like to acknowledge support of the U. S. Army Research Laboratory (ARL). JS authors would like to acknowledge the support of the U.S. Army Research Office (ARO). The authors would like to acknowledge support of the Maryland NanoCenter and its Nanoscale Imaging Spectroscopy and Properties Laboratory. The Nanoscale Imaging Spectroscopy and Properties Laboratory are supported in part by the NSF as a MRSEC Shared Experimental Facility. In particular, the help of Dr. W. A. Chiou and Dr. L.-C. Lai of Nanoscale Imaging Spectroscopy and Properties Laboratory are greatly appreciated. NR 12 TC 20 Z9 20 U1 4 U2 69 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD MAY PY 2012 VL 47 IS 10 BP 4428 EP 4431 DI 10.1007/s10853-012-6300-y PG 4 WC Materials Science, Multidisciplinary SC Materials Science GA 918IM UT WOS:000302242700023 ER PT J AU Katz, A Sankaran, V AF Katz, Aaron Sankaran, Venkateswaran TI An Efficient Correction Method to Obtain a Formally Third-Order Accurate Flow Solver for Node-Centered Unstructured Grids SO JOURNAL OF SCIENTIFIC COMPUTING LA English DT Article DE Computational fluid dynamics; High-order methods; Unstructured grids ID DISCONTINUOUS GALERKIN METHOD; COMPRESSIBLE FLOWS; EULER EQUATIONS; SCHEMES; MESHES AB A new method of obtaining third-order accuracy on unstructured grid flow solvers is presented. The method involves a simple correction to a traditional linear Galerkin scheme on tetrahedra and can be conveniently added to existing second-order accurate node-centered flow solvers. The correction involves gradients of the flux computed with a quadratic least squares approximation. However, once the gradients are computed, no second derivative information or high-order quadrature is necessary to achieve third-order accuracy. The scheme is analyzed both analytically using truncation error, and numerically using solution error for an exact solution to the Euler equations. Two demonstration cases for steady, inviscid flow reveal increased accuracy and excellent shock capturing with no loss in steady-state convergence rate. Computational timing results are presented which show the additional expense from the correction is modest compared to the increase in accuracy. C1 [Katz, Aaron; Sankaran, Venkateswaran] USA, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. RP Katz, A (reprint author), USA, Aeroflightdynam Directorate AMRDEC, Moffett Field, CA 94035 USA. EM akatz@merlin.arc.nasa.gov RI Katz, Aaron/I-8244-2015 OI Katz, Aaron/0000-0003-2739-9384 FU U.S. Department of Defense HPC Modernization Program Office FX Development was performed at the HPC Institute for Advanced Rotorcraft Modeling and Simulation (HIARMS) located at the US Army Aeroflightdynamics Directorate at Moffett Field, CA, which is supported by the Department of Defense High Performance Computing Modernization Office (HPCMO). Material presented in this paper is a product of the CREATE-AV Element of the Computational Research and Engineering for Acquisition Tools and Environments (CREATE) Program sponsored by the U.S. Department of Defense HPC Modernization Program Office. NR 20 TC 13 Z9 13 U1 1 U2 2 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0885-7474 J9 J SCI COMPUT JI J. Sci. Comput. PD MAY PY 2012 VL 51 IS 2 BP 375 EP 393 DI 10.1007/s10915-011-9515-1 PG 19 WC Mathematics, Applied SC Mathematics GA 918OO UT WOS:000302259900006 ER PT J AU Chang, YC Gao, YH Wang, C Yao, J Cheng, JP Yin, S Ruffin, P Brantley, C Edwards, E Luo, C AF Chang, Yun-ching Gao, Yaohui Wang, Chao Yao, Jimmy Cheng, Jiping Yin, Stuart Ruffin, Paul Brantley, Christina Edwards, Eugene Luo, Claire TI Noncontact detection of the location of buried conductive grids with pulsed THz wave SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS LA English DT Article DE noncontact detection; terahertz wave; conductive grid AB In this article, a new method for precisely measuring the location of buried conductive grid based on time-domain pulsed terahertz (THz) reflectometry is presented. The location of the buried conductive grid is determined by the time difference of reflected THz pulses between the front surface and the buried conductive grid. Since the wavelength of THz wave is usually larger than the roughness of unpolished optical surface and the period of conductive grid, the proposed method is insensitive to the surface condition. Furthermore, this is a non-contact and real-time measurement technique. The experimental result indicates that the accuracy of the measurement is at least on the order of 10 mu m. Such kind of technique will be very helpful for enhancing the quality and reduce the cost of fabricating electro-optic windows with embedded conductive grids and/or wires. It can also be beneficial for some other applications. For example, since there are often embedded conductive wires in explosive devices, it can be used to detect the explosive devices because the proposed method can remotely determine the dimensions and locations of conductive wires embedded in dielectric enclosures. (C) 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:11351138, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26755 C1 [Chang, Yun-ching; Gao, Yaohui; Wang, Chao; Yao, Jimmy; Cheng, Jiping; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA. RP Chang, YC (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU ONR FX Authors greatly acknowledge the partial financial support of this work by an ONR basic research program. NR 5 TC 0 Z9 0 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0895-2477 J9 MICROW OPT TECHN LET JI Microw. Opt. Technol. Lett. PD MAY PY 2012 VL 54 IS 5 BP 1135 EP 1138 DI 10.1002/mop.26755 PG 4 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA 907QA UT WOS:000301431200006 ER PT J AU Bartolucci, SF Mago, G Fisher, FT Troiano, E Kalyon, DM AF Bartolucci, Stephen F. Mago, Gaurav Fisher, Frank T. Troiano, Edward Kalyon, Dilhan M. TI Unusual fracture surface morphology of fatigued carbon nanofiber/poly(ether ether ketone) composites SO CARBON LA English DT Article ID NANOTUBES AB Carbon nanofiber/poly(ether ether ketone) composites were prepared in the laboratory via a solvent-based method at 260 degrees C using benzophenone. After fatigue testing, examination of the fracture surface shows unusual surface morphologies around the nanofibers that appear to be caused by the cyclic testing. Published by Elsevier Ltd. C1 [Bartolucci, Stephen F.; Troiano, Edward] USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. [Mago, Gaurav; Fisher, Frank T.] Stevens Inst Technol, Dept Mech Engn, Hoboken, NJ 07030 USA. [Kalyon, Dilhan M.] Stevens Inst Technol, Highly Filled Mat Inst, Hoboken, NJ 07030 USA. [Kalyon, Dilhan M.] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA. RP Bartolucci, SF (reprint author), USA, Benet Labs, Armaments Res Dev & Engn Ctr, 1 Buffington St, Watervliet, NY 12189 USA. EM stephen.f.bartolucci.civ@mail.mil RI mago, gaurav/A-6753-2013; Mago, Gaurav/I-3356-2013 OI mago, gaurav/0000-0003-2316-8458; NR 10 TC 1 Z9 1 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD MAY PY 2012 VL 50 IS 6 BP 2359 EP 2361 DI 10.1016/j.carbon.2012.01.034 PG 3 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 915TL UT WOS:000302050200038 ER PT J AU Hoyer, MV Canfield, DE Netherland, MD Leeper, DA AF Hoyer, Mark V. Canfield, Daniel E., Jr. Netherland, Michael D. Leeper, Douglas A. TI Lack of lake augmentation effects on aquatic macrophyte abundance and distribution in west-central Florida lakes, USA SO HYDROBIOLOGIA LA English DT Article DE Minimum lake levels; Net photosynthesis; Total alkalinity; Total phosphorus; Phosphorus precipitation ID MAXIMUM DEPTH; WASTE-WATER; GROUNDWATER; BIOMASS; HYDRILLA; PHYTOPLANKTON; COLONIZATION; ACCUMULATION; COMMUNITIES; PHOSPHORUS AB This study tested the hypothesis that lake augmentation with well water impacts the distribution and abundance of aquatic plants in lakes. Water chemistry was measured from 14 wells, 14 augmented lakes, and 14 lakes without augmentation. Nine in-lake aquatic macrophyte abundance and species distribution metrics were measured in all lakes. Net photosynthetic rate (NPR) of nine submersed species was also measured in well and lake water. Augmentation increased alkalinity in receiving lakes, but total phosphorus was significantly lower, which resulted in lower chlorophyll and greater Secchi depths. Although measured NPR was higher for all plants incubated in well water, only one (emergent species richness) in-lake aquatic macrophyte metric was different in lakes with and without augmentation. Lake augmentation significantly changed water chemistry of receiving waters, but effects on aquatic macrophytes were minimal, suggesting that other environmental factors are limiting the distribution and abundance of macrophytes in the study lakes. The lower phosphorus levels in augmented lakes were unexpected because phosphorus concentrations in well water were significantly greater than in lakes with or without augmentation. Precipitation of calcium phosphate likely accounts for the reduced phosphorus levels in augmented lakes. C1 [Hoyer, Mark V.; Canfield, Daniel E., Jr.] Univ Florida, Sch Forest Resources & Conservat, IFAS, Gainesville, FL 32653 USA. [Netherland, Michael D.] Ctr Aquat & Invas Plants, USACE ERDC Environm Lab, Gainesville, FL 32653 USA. [Leeper, Douglas A.] SW Florida Water Management Dist, Resource Projects Dept, Brooksville, FL 34604 USA. RP Hoyer, MV (reprint author), Univ Florida, Sch Forest Resources & Conservat, IFAS, 7922 NW 71st St, Gainesville, FL 32653 USA. EM mvhoyer@ufl.edu FU Southwest Florida Water Management District FX We thank the Southwest Florida Water Management District for supporting this research. We thank all of the Florida LAKEWATCH volunteers who help collecting the data used in support of this project and other stake-holder who granted access to lakes and wells for sampling purposes. NR 54 TC 0 Z9 0 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0018-8158 EI 1573-5117 J9 HYDROBIOLOGIA JI Hydrobiologia PD MAY PY 2012 VL 686 IS 1 BP 29 EP 40 DI 10.1007/s10750-011-0983-y PG 12 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 912EX UT WOS:000301778600003 ER PT J AU Liu, ZP Cai, SS Swan, JE Moorhead, RJ Martin, JP Jankun-Kelly, TJ AF Liu, Zhanping Cai, Shangshu Swan, J. Edward, II Moorhead, Robert J., II Martin, Joel P. Jankun-Kelly, T. J. TI A 2D Flow Visualization User Study Using Explicit Flow Synthesis and Implicit Task Design SO IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS LA English DT Article DE Flow visualization; user study; visualization effectiveness; flow synthesis; task design; test strategy; LIC; evenly spaced streamlines ID OF-THE-ART; SURFACES; TOPOLOGY AB This paper presents a 2D flow visualization user study that we conducted using new methodologies to increase the objectiveness. We evaluated grid-based variable-size arrows, evenly spaced streamlines, and line integral convolution (LIC) variants (basic, oriented, and enhanced versions) coupled with a colorwheel and/or rainbow color map, which are representative of many geometry-based and texture-based techniques. To reduce data-related bias, template-based explicit flow synthesis was used to create a wide variety of symmetric flows with similar topological complexity. To suppress task-related bias, pattern-based implicit task design was employed, addressing critical point recognition, critical point classification, and symmetric pattern categorization. In addition, variable-duration and fixed-duration measurement schemes were utilized for lightweight precision-critical and heavyweight judgment-intensive flow analysis tasks, respectively, to record visualization effectiveness. We eliminated outliers and used the Ryan REGWQ post-hoc homogeneous subset tests in statistical analysis to obtain reliable findings. Our study shows that a texture-based dense representation with accentuated flow streaks, such as enhanced LIC, enables intuitive perception of the flow, while a geometry-based integral representation with uniform density control, such as evenly spaced streamlines, may exploit visual interpolation to facilitate mental reconstruction of the flow. It is also shown that inappropriate color mapping (e.g., colorwheel) may add distractions to a flow representation. C1 [Liu, Zhanping] Kentucky State Univ, Dept Comp Sci, Frankfort, KY 40601 USA. [Cai, Shangshu] Univ Calif Santa Barbara, Ctr Risk Studies & Safety, Goleta, CA 93117 USA. [Swan, J. Edward, II; Jankun-Kelly, T. J.] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Moorhead, Robert J., II] Mississippi State Univ, Geosyst Res Inst, Mississippi State, MS 39762 USA. [Moorhead, Robert J., II] Mississippi State Univ, Dept Elect & Comp Engn, Mississippi State, MS 39762 USA. [Martin, Joel P.] USA, Res Lab, Aberdeen, MD 21001 USA. RP Liu, ZP (reprint author), Kentucky State Univ, Dept Comp Sci, 314G Hathaway Hall,400 E Main St, Frankfort, KY 40601 USA. EM zhanpingliu@hotmail.com; raymondcai@engineering.ucsb.edu; swan@acm.org; rjm@gri.msstate.edu; martin5@us.army.mil; tjk@acm.org FU High Performance Computing and Visualization Initiative (HPCVI); DoD High Performance Computing Modernization Program (HPCMP) through the Army Corps of Engineers Engineering Research and Development Center (ERDC); Jackson State University FX This work was supported by the High Performance Computing and Visualization Initiative (HPCVI) funding provided by the DoD High Performance Computing Modernization Program (HPCMP) through the Army Corps of Engineers Engineering Research and Development Center (ERDC) and Jackson State University. The authors would like to thank David Laidlaw for his suggestions on designing the user study and developing the test system, and the anonymous reviewers for the valuable comments. NR 30 TC 5 Z9 6 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1077-2626 EI 1941-0506 J9 IEEE T VIS COMPUT GR JI IEEE Trans. Vis. Comput. Graph. PD MAY PY 2012 VL 18 IS 5 BP 783 EP 796 DI 10.1109/TVCG.2011.110 PG 14 WC Computer Science, Software Engineering SC Computer Science GA 904YB UT WOS:000301234200011 PM 21690646 ER PT J AU Peng, AC Riolli, LT Schaubroeck, J Spain, ESP AF Peng, Ann Chunyan Riolli, Laura T. Schaubroeck, John Spain, Everett S. P. TI A moderated mediation test of personality, coping, and health among deployed soldiers SO JOURNAL OF ORGANIZATIONAL BEHAVIOR LA English DT Article DE personality; coping; combat stress; psychological distress ID POSTTRAUMATIC-STRESS-DISORDER; BRIEF SYMPTOM INVENTORY; GULF-WAR VETERANS; BIG 5 TRAITS; SOCIAL SUPPORT; MENTAL-HEALTH; TRAUMATIC STRESS; JOB-PERFORMANCE; METHOD VARIANCE; PTSD SYMPTOMS AB Our study examines how personality and coping influence soldiers' psychological health among 648 US Army personnel who were at that time deployed in Iraq at the height of an insurgency. Conscientiousness, neuroticism, and extraversion were associated with different coping behaviors, and these were in turn related to psychological distress. Conscientiousness was positively associated with problem-focused coping and negatively with avoidance coping, whereas neuroticism was most positively associated with avoidance coping. Extraversion was positively related to both seeking social support and avoidance coping. As expected, avoidance coping was positively associated with psychological distress. Coping style explained more variance in the relationship between personality and distress among soldiers who perceived higher levels of threat, thus supporting a moderated mediation hypothesis. We discuss implications for facilitating the stress coping of workers who face acute and potentially traumatic stress exposures. Copyright (C) 2011 John Wiley & Sons, Ltd. C1 [Peng, Ann Chunyan; Schaubroeck, John] Michigan State Univ, Dept Management, E Lansing, MI 48824 USA. [Riolli, Laura T.] Calif State Univ Sacramento, Coll Business Adm, Sacramento, CA 95819 USA. [Schaubroeck, John] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA. [Spain, Everett S. P.] USA, Washington, DC USA. RP Peng, AC (reprint author), Michigan State Univ, Dept Management, E Lansing, MI 48824 USA. EM pengchu1@msu.edu RI Schaubroeck, John/L-3255-2013 OI Schaubroeck, John/0000-0001-9204-3603 NR 87 TC 7 Z9 7 U1 6 U2 39 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0894-3796 J9 J ORGAN BEHAV JI J. Organ. Behav. PD MAY PY 2012 VL 33 IS 4 BP 512 EP 530 DI 10.1002/job.766 PG 19 WC Business; Psychology, Applied; Management SC Business & Economics; Psychology GA 908YV UT WOS:000301529900005 ER PT J AU Bermudez-Aguirre, D Dunne, CP Barbosa-Canovas, GV AF Bermudez-Aguirre, Daniela Dunne, C. Patrick Barbosa-Canovas, Gustavo V. TI Effect of processing parameters on inactivation of Bacillus cereus spores in milk using pulsed electric fields SO INTERNATIONAL DAIRY JOURNAL LA English DT Article ID SKIM MILK; ESCHERICHIA-COLI; LISTERIA-INNOCUA; SACCHAROMYCES-CEREVISIAE; PASTEURIZED MILK; NISIN; HEAT; TEMPERATURE; PRESSURE; FOOD AB The inactivation of Bacillus cereus spores in milk by treatment using pulsed electric fields (PEF) was studied. The effects of the electric field, temperature, number of pulses, pulse width, frequency and nisin concentration were tested in skim and whole milk. Results showed high resistance of spores to PEF alone; mild thermal treatment (40 degrees C) applied together with PEF had an antagonistic effect, and treatment at 50 degrees C enhanced spore death. Skim milk was a better medium than whole milk for inactivation; stronger thermal treatment (65 degrees C) together with PEF achieved a slight increase in spore reduction. The effect of pulse width was not consistent. Addition of nisin (50 IU mL(-1)) was synergistically effective (40 kV cm(-1), 144 pulses, 65 degrees C), reducing spore count (by 3.6 log) in skim milk. Regardless of the severity of the treatment, spores showed resistance to the different processing variables. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Bermudez-Aguirre, Daniela; Barbosa-Canovas, Gustavo V.] Washington State Univ, Ctr Nonthermal Proc Food, Pullman, WA 99164 USA. [Dunne, C. Patrick] USA, Natick Soldier RDEC Natick, Natick, MA 01760 USA. RP Bermudez-Aguirre, D (reprint author), Washington State Univ, Ctr Nonthermal Proc Food, Pullman, WA 99164 USA. EM daniela@wsu.edu FU US Army Natick Soldier RDEC (Natick, MA) FX The authors acknowledge the financial support of US Army Natick Soldier RDEC (Natick, MA) for this project. NR 49 TC 21 Z9 21 U1 3 U2 41 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0958-6946 J9 INT DAIRY J JI Int. Dairy J. PD MAY PY 2012 VL 24 IS 1 BP 13 EP 21 DI 10.1016/j.idairyj.2011.11.003 PG 9 WC Food Science & Technology SC Food Science & Technology GA 902RD UT WOS:000301055200003 ER PT J AU Ayvaz, H Schirmer, S Parulekar, Y Balasubramaniam, VM Somerville, JA Daryaei, H AF Ayvaz, Huseyin Schirmer, Sarah Parulekar, Yash Balasubramaniam, V. M. Somerville, Jeremy A. Daryaei, Hossein TI Influence of selected packaging materials on some quality aspects of pressure-assisted thermally processed carrots during storage SO LWT-FOOD SCIENCE AND TECHNOLOGY LA English DT Article DE Barrier properties; Packaging materials; Pressure-assisted thermal processing; High pressure processing; Baby carrots; Storage stability ID CLOSTRIDIUM-BOTULINUM; BARRIER PROPERTIES; BETA-CAROTENE; TOMATO JUICE; GREEN BEANS; FILMS; HEAT; STABILITY; SPORES; STERILIZATION AB Role of packaging barrier properties and storage conditions on pressure-assisted thermally processed (PATP) carrot quality were investigated. Samples were packaged in pouches fabricated using three packaging materials (Nylon/EVOH/EVA, Nylon/EVA and MetPET/PE) and processed at 600 MPa and 110 degrees C for 10 minutes. Processed pouches were stored at 25 and 37 degrees C, and withdrawn over 12 weeks. Samples were analyzed for color, beta-carotene and total plate count. Oxygen and water vapor transmission rates (OTR, WVTR), melting point and enthalpy of fusion of the packages were evaluated. PATP treatment resulted in product shelf-stability during storage. Packaging type and storage conditions significantly influenced the product color and beta-carotene content. Nylon/EVOH/EVA package best preserved carrot quality. PATP increased OTR of the MetPET/PE and degraded carrot color and beta-carotene during storage. Raw carrots had 11.13 mg/100g beta-carotene content. PATP treatment followed by 12 weeks storage at 37 degrees C reduced the beta-carotene content of carrots packaged in Nylon/EVOH/EVA, Nylon/EVA and MetPET/PE to 7.19, 0.04 and 0.06 mg/100g, respectively. Similarly, the red color of carrot samples (25.51 for raw carrots) decreased to 19.85, 3.44 and 7.20 for Nylon/EVOH/EVA, Nylon/EVA and MetPET/PE, respectively. The study demonstrated the importance of high barrier packaging materials in preserving PATP-treated carrot quality. (C)2011 Elsevier Ltd. All rights reserved. C1 [Ayvaz, Huseyin; Balasubramaniam, V. M.; Somerville, Jeremy A.; Daryaei, Hossein] Ohio State Univ, Dept Food Sci & Technol, Food Safety Engn Lab, Columbus, OH 43210 USA. [Schirmer, Sarah] USA, Adv Mat Engn Team, Combat Feeding Directorate, NSRDEC Natick, Natick, MA 01760 USA. [Parulekar, Yash] Appleton Papers Inc, Appleton, WI 54912 USA. RP Balasubramaniam, VM (reprint author), Ohio State Univ, Dept Food Sci & Technol, Food Safety Engn Lab, Parker Food Sci & Technol Bldg,2015 Fyffe Rd, Columbus, OH 43210 USA. EM balasubramaniam.1@osu.edu RI Balasubramaniam, VM Bala/A-2576-2008 OI Balasubramaniam, VM Bala/0000-0002-1540-4273 FU Appleton Papers Inc. [W911QY-08-C-0085]; US Army Natick Soldier Systems Center; Turkish Ministry of Education FX Author Ayvaz gratefully thank Turkish Ministry of Education for providing the scholarship supporting his graduate studies at The Ohio State University. The authors are grateful for the financial support provided by Appleton Papers Inc. under contract W911QY-08-C-0085 with the US Army Natick Soldier Systems Center. Authors also thank Appleton Papers for providing necessary packaging material used for the research. References to commercial products or trade names are made with the understanding that no endorsement or discrimination by The Ohio State University is implied. NR 39 TC 6 Z9 6 U1 1 U2 38 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0023-6438 J9 LWT-FOOD SCI TECHNOL JI LWT-Food Sci. Technol. PD MAY PY 2012 VL 46 IS 2 BP 437 EP 447 DI 10.1016/j.lwt.2011.12.004 PG 11 WC Food Science & Technology SC Food Science & Technology GA 896WR UT WOS:000300602600010 ER PT J AU Hawksworth, JS Graybill, JC Brown, TS Wallace, SM Davis, TA Tadaki, DK Elster, EA AF Hawksworth, Jason S. Graybill, J. Christopher Brown, Trevor S. Wallace, Shannon M. Davis, Thomas A. Tadaki, Doug K. Elster, Eric A. TI Lymphocyte Modulation with FTY720 Improves Hemorrhagic Shock Survival in Swine SO PLOS ONE LA English DT Article ID RESPIRATORY-DISTRESS SYNDROME; ISCHEMIA-REPERFUSION INJURY; T-LYMPHOCYTES; ISCHEMIA/REPERFUSION INJURY; SPHINGOSINE 1-PHOSPHATE; CLINICAL-TRIALS; TRAUMA PATIENTS; CELL; NEUTROPHIL; SPHINGOSINE-1-PHOSPHATE AB The inflammatory response to severe traumatic injury results in significant morbidity and mortality. Lymphocytes have recently been identified as critical mediators of the early innate immune response to ischemia-reperfusion injury. Experimental manipulation of lymphocytes following hemorrhagic shock may prevent secondary immunologic injury in surgical and trauma patients. The objective of this study is to evaluate the lymphocyte sequestration agent FTY720 as an immunomodulator following experimental hemorrhagic shock in a swine liver injury model. Yorkshire swine were anesthetized and underwent a grade III liver injury with uncontrolled hemorrhage to induce hemorrhagic shock. Experimental groups were treated with a lymphocyte sequestration agent, FTY720, (n = 9) and compared to a vehicle control group (n = 9). Animals were observed over a 3 day survival period after hemorrhage. Circulating total leukocyte and neutrophil counts were measured. Central lymphocytes were evaluated with mesenteric lymph node and spleen immunohistochemistry (IHC) staining for CD3. Lung tissue infiltrating neutrophils were analyzed with myeloperoxidase (MPO) IHC staining. Relevant immune-related gene expression from liver tissue was quantified using RT-PCR. The overall survival was 22.2% in the vehicle control and 66.7% in the FTY720 groups (p = 0.081), and reperfusion survival (period after hemorrhage) was 25% in the vehicle control and 75% in the FTY720 groups (p = 0.047). CD3(+) lymphocytes were significantly increased in mesenteric lymph nodes and spleen in the FTY720 group compared to vehicle control, indicating central lymphocyte sequestration. Lymphocyte disruption significantly decreased circulating and lung tissue infiltrating neutrophils, and decreased expression of liver immune-related gene expression in the FTY720 treated group. There were no observed infectious or wound healing complications. Lymphocyte sequestration with FTY720 improves survival in experimental hemorrhagic shock using a porcine liver injury model. These results support a novel and clinically relevant lymphocyte immunomodulation strategy to ameliorate secondary immune injury in hemorrhagic shock. C1 [Hawksworth, Jason S.; Graybill, J. Christopher; Brown, Trevor S.; Davis, Thomas A.; Tadaki, Doug K.; Elster, Eric A.] USN, Regenerat Med Dept, Operat & Undersea Med Directorate, Med Res Ctr, Silver Spring, MD 20910 USA. [Hawksworth, Jason S.; Graybill, J. Christopher; Elster, Eric A.] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD USA. [Tadaki, Doug K.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wallace, Shannon M.] Walter Reed Army Inst Res, Dept Diagnost Pathol, Silver Spring, MD USA. RP Hawksworth, JS (reprint author), USN, Regenerat Med Dept, Operat & Undersea Med Directorate, Med Res Ctr, Silver Spring, MD 20910 USA. EM doug.tadaki@med.navy.mil; eric.elster1@med.navy.mil RI Brown, Trevor/K-4703-2012; Brown, Trevor/F-7392-2015 OI Brown, Trevor/0000-0001-7042-785X; Brown, Trevor/0000-0001-7042-785X FU Office of Naval Research (work unit number 603729N.02914.W280.A0515) FX This work was supported by the Office of Naval Research (work unit number 603729N.02914.W280.A0515). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 8 Z9 8 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 30 PY 2012 VL 7 IS 4 AR e34224 DI 10.1371/journal.pone.0034224 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959UL UT WOS:000305340200004 PM 22558085 ER PT J AU Mao, XH Wang, J Ciblak, A Cox, EE Riis, C Terkelsen, M Gent, DB Alshawabkeh, AN AF Mao, Xuhui Wang, James Ciblak, Ali Cox, Evan E. Riis, Charlotte Terkelsen, Mads Gent, David B. Alshawabkeh, Akram N. TI Electrokinetic-enhanced bioaugmentation for remediation of chlorinated solvents contaminated clay SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Bioaugmentation; Electrokinetic injection; Contaminated clay; Bacteria transport; Chlorinated solvents ID FIELD DEMONSTRATION; VINYL-CHLORIDE; SOIL; TRICHLOROETHYLENE; TETRACHLOROETHENE; DECHLORINATION; HYDROCARBONS; PHENANTHRENE; REDUCTION; TRANSPORT AB Successful bioremediation of contaminated soils is controlled by the ability to deliver bioremediation additives, such as bacteria and/or nutrients, to the contaminated zone. Because hydraulic advection is not practical for delivery in clays, electrokinetic (EK) injection is an alternative for efficient and uniform delivery of bioremediation additive into low-permeability soil and heterogeneous deposits. EK-enhanced bioaugmentation for remediation of clays contaminated with chlorinated solvents is evaluated. Dehalococcoides (Dhc) bacterial strain and lactate ions are uniformly injected in contaminated clay and complete dechlorination of chlorinated ethene is observed in laboratory experiments. The injected bacteria can survive, grow, and promote effective dechlorination under EK conditions and after EK application. The distribution of Dhc within the clay suggests that electrokinetic transport of Dhc is primarily driven by electroosmosis. In addition to biodegradation due to bioaugmentation of Dhc. an EK-driven transport of chlorinated ethenes is observed in the clay, which accelerates cleanup of chlorinated ethenes from the anode side. Compared with conventional advection-based delivery, EK injection is significantly more effective for establishing microbial reductive dechlorination capacity in low-permeability soils. (C) 2012 Elsevier B.V. All rights reserved. C1 [Mao, Xuhui; Ciblak, Ali; Alshawabkeh, Akram N.] Northeastern Univ, Dept Civil & Environm Engn, Boston, MA 02115 USA. [Wang, James; Cox, Evan E.] Geosyntec Consultants, Columbia, MA USA. [Riis, Charlotte] NIRAS AS, Allerod, Denmark. [Terkelsen, Mads] Capital Reg Denmark, Hillerod, Denmark. [Gent, David B.] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. [Mao, Xuhui] Wuhan Univ, Sch Resources & Environm Sci, Wuhan 430079, Peoples R China. RP Alshawabkeh, AN (reprint author), 400 Snell Engn Ctr,360 Huntington Ave, Boston, MA 02115 USA. EM x.mao@neu.edu; aalsha@neu.edu OI Mao, Xuhui/0000-0003-1720-255X FU Capital Region of Denmark; National Institute of Environmental Health Sciences [P42ES017198]; NSFC [51108353] FX The work conducted for this project is funded by the Capital Region of Denmark and by award number P42ES017198 from the National Institute of Environmental Health Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Capital Region of Denmark, the National Institute of Environmental Health Sciences or the National Institutes of Health. Xuhui Mao also thanks NSFC (51108353) for financial support. NR 21 TC 13 Z9 13 U1 2 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR 30 PY 2012 VL 213 BP 311 EP 317 DI 10.1016/j.jhazmat.2012.02.001 PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 927FS UT WOS:000302893100039 PM 22365139 ER PT J AU Brocato, R Josleyn, M Ballantyne, J Vial, P Hooper, JW AF Brocato, Rebecca Josleyn, Matthew Ballantyne, John Vial, Pablo Hooper, Jay W. TI DNA Vaccine-Generated Duck Polyclonal Antibodies as a Postexposure Prophylactic to Prevent Hantavirus Pulmonary Syndrome (HPS) SO PLOS ONE LA English DT Article ID ARGENTINE HEMORRHAGIC-FEVER; TO-PERSON TRANSMISSION; ANDES VIRUS; INCUBATION PERIOD; NEUTRALIZING ANTIBODIES; PROTECTS HAMSTERS; IMMUNE PLASMA; INFECTION; IGY; IMMUNOGLOBULINS AB Andes virus (ANDV) is the predominant cause of hantavirus pulmonary syndrome (HPS) in South America and the only hantavirus known to be transmitted person-to-person. There are no vaccines, prophylactics, or therapeutics to prevent or treat this highly pathogenic disease (case-fatality 35-40%). Infection of Syrian hamsters with ANDV results in a disease that closely mimics human HPS in incubation time, symptoms of respiratory distress, and disease pathology. Here, we evaluated the feasibility of two postexposure prophylaxis strategies in the ANDV/hamster lethal disease model. First, we evaluated a natural product, human polyclonal antibody, obtained as fresh frozen plasma (FFP) from a HPS survivor. Second, we used DNA vaccine technology to manufacture a polyclonal immunoglobulin-based product that could be purified from the eggs of vaccinated ducks (Anas platyrhynchos). The natural "despeciation" of the duck IgY (i.e., Fc removed) results in an immunoglobulin predicted to be minimally reactogenic in humans. Administration of >= 5,000 neutralizing antibody units (NAU)/kg of FFP-protected hamsters from lethal disease when given up to 8 days after intranasal ANDV challenge. IgY/IgYDFc antibodies purified from the eggs of DNA-vaccinated ducks effectively neutralized ANDV in vitro as measured by plaque reduction neutralization tests (PRNT). Administration of 12,000 NAU/kg of duck egg-derived IgY/IgYDFc protected hamsters when administered up to 8 days after intranasal challenge and 5 days after intramuscular challenge. These experiments demonstrate that convalescent FFP shows promise as a postexposure HPS prophylactic. Moreover, these data demonstrate the feasibility of using DNA vaccine technology coupled with the duck/egg system to manufacture a product that could supplement or replace FFP. The DNA vaccine-duck/egg system can be scaled as needed and obviates the necessity of using limited blood products obtained from a small number of HPS survivors. This is the first report demonstrating the in vivo efficacy of any antiviral product produced using DNA vaccine-duck/egg system. C1 [Brocato, Rebecca; Josleyn, Matthew; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Ballantyne, John] Aldevron LLC, Fargo, ND USA. [Vial, Pablo] Clin Alemana Univ Desarrollo, Sch Med, Inst Sci, Santiago, Chile. RP Brocato, R (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM jay.w.hooper@us.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU Military Infectious Disease Research Program (MIDRP), Program Area T; Chemical Biological Medical Systems (CBMS); National Institutes of Health [U01AI045452] FX This work was funded by the Military Infectious Disease Research Program (MIDRP), Program Area T; by Chemical Biological Medical Systems (CBMS) and by National Institutes of Health U01AI045452. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 16 Z9 16 U1 0 U2 8 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 27 PY 2012 VL 7 IS 4 AR e35996 DI 10.1371/journal.pone.0035996 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959TJ UT WOS:000305336000097 PM 22558299 ER PT J AU Miklos, AE Kluwe, C Der, BS Pai, SP Sircar, A Hughes, RA Berrondo, M Xu, JQ Codrea, V Buckley, PE Calm, AM Welsh, HS Warner, CR Zacharko, MA Carney, JP Gray, JJ Georgiou, G Kuhlman, B Ellington, AD AF Miklos, Aleksandr E. Kluwe, Christien Der, Bryan S. Pai, Supriya Sircar, Aroop Hughes, Randall A. Berrondo, Monica Xu, Jianqing Codrea, Vlad Buckley, Patricia E. Calm, Alena M. Welsh, Heather S. Warner, Candice R. Zacharko, Melody A. Carney, James P. Gray, Jeffrey J. Georgiou, George Kuhlman, Brian Ellington, Andrew D. TI Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies SO CHEMISTRY & BIOLOGY LA English DT Article ID PROTEIN INTERACTIONS; PHAGE DISPLAY; AGGREGATION; STABILITY; BINDING AB Mutation of surface residues to charged amino acids increases resistance to aggregation and can enable reversible unfolding. We have developed a protocol using the Rosetta computational design package that "supercharges" proteins while considering the energetic implications of each mutation. Using a homology model, a single-chain variable fragment antibody was designed that has a markedly enhanced resistance to thermal inactivation and displays an unanticipated approximate to 30-fold improvement in affinity. Such supercharged antibodies should prove useful for assays in resource-limited settings and for developing reagents with improved shelf lives. C1 [Miklos, Aleksandr E.; Kluwe, Christien; Hughes, Randall A.; Codrea, Vlad; Ellington, Andrew D.] Univ Texas Austin, Ctr Syst & Synthet Biol, Austin, TX 78712 USA. [Miklos, Aleksandr E.; Kluwe, Christien; Pai, Supriya; Hughes, Randall A.; Georgiou, George; Ellington, Andrew D.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. [Miklos, Aleksandr E.; Hughes, Randall A.; Ellington, Andrew D.] Univ Texas Austin, Appl Res Labs, Austin, TX 78712 USA. [Der, Bryan S.; Kuhlman, Brian] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA. [Sircar, Aroop; Berrondo, Monica; Xu, Jianqing; Gray, Jeffrey J.] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA. [Buckley, Patricia E.; Calm, Alena M.; Welsh, Heather S.; Carney, James P.] USA, Biosci Div, Edgewood Biol Chem Res Ctr, Aberdeen Proving Ground, MD 21010 USA. [Warner, Candice R.; Zacharko, Melody A.] Excet Inc, Springfield, VA 22151 USA. RP Ellington, AD (reprint author), Univ Texas Austin, Ctr Syst & Synthet Biol, Austin, TX 78712 USA. EM ellingtonlab@gmail.com OI Gray, Jeffrey/0000-0001-6380-2324 FU DARPA [HR-0011-10-1-0052] FX The authors wish to acknowledge Arti Pothukuchy and Carolyn Hargrave for technical support. This work was funded by the DARPA Antibody Technology Program (HR-0011-10-1-0052). NR 22 TC 50 Z9 50 U1 1 U2 28 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 1074-5521 J9 CHEM BIOL JI Chem. Biol. PD APR 20 PY 2012 VL 19 IS 4 BP 449 EP 455 DI 10.1016/j.chembiol.2012.01.018 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 933OL UT WOS:000303371500007 PM 22520751 ER PT J AU Perovich, DK Polashenski, C AF Perovich, Donald K. Polashenski, Christopher TI Albedo evolution of seasonal Arctic sea ice SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID SURFACE HEAT-BUDGET; OCEAN; COVER; SUMMER; SHEBA AB There is an ongoing shift in the Arctic sea ice cover from multiyear ice to seasonal ice. Here we examine the impact of this shift on sea ice albedo. Our analysis of observations from four years of field experiments indicates that seasonal ice undergoes an albedo evolution with seven phases; cold snow, melting snow, pond formation, pond drainage, pond evolution, open water, and freezeup. Once surface ice melt begins, seasonal ice albedos are consistently less than albedos for multiyear ice resulting in more solar heat absorbed in the ice and transmitted to the ocean. The shift from a multiyear to seasonal ice cover has significant implications for the heat and mass budget of the ice and for primary productivity in the upper ocean. There will be enhanced melting of the ice cover and an increase in the amount of sunlight available in the upper ocean. Citation: Perovich, D. K., and C. Polashenski (2012), Albedo evolution of seasonal Arctic sea ice, Geophys. Res. Lett., 39, L08501, doi:10.1029/2012GL051432. C1 [Perovich, Donald K.; Polashenski, Christopher] Erdc, CRREL, Hanover, NH 03755 USA. [Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Perovich, DK (reprint author), Erdc, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM perovich@crrel.usace.army.mil FU National Science Foundation FX Financial support was provided by the National Science Foundation Arctic Observing Network and Arctic System Science Programs. We thank T. C. Grenfell and Z. Courville for their assistance with the albedo measurements. NR 27 TC 82 Z9 85 U1 4 U2 46 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD APR 20 PY 2012 VL 39 AR L08501 DI 10.1029/2012GL051432 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 930DB UT WOS:000303115900005 ER PT J AU Wilson, JM Grant, SC Lee, SR Masad, IS Park, YM Henning, PC Stout, JR Loenneke, JP Arjmandi, BH Panton, LB Kim, JS AF Wilson, Jacob M. Grant, Samuel C. Lee, Sang-Rok Masad, Ihssan S. Park, Young-Min Henning, Paul C. Stout, Jeffery R. Loenneke, Jeremy P. Arjmandi, Bahram H. Panton, Lynn B. Kim, Jeong-Su TI Beta-hydroxy-beta-methyl-butyrate blunts negative age-related changes in body composition, functionality and myofiber dimensions in rats SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article DE Beta-hydroxy-beta-methylbutyrate; Aging; Fat-free mass; Strength; Sarcopenia ID HUMAN SKELETAL-MUSCLE; FED AD-LIBITUM; METHYLBUTYRATE HMB; PROTEIN-SYNTHESIS; UBIQUITIN LIGASES; AMINO-ACIDS; STRENGTH; YOUNG; MEN; SUPPLEMENTATION AB Purpose: To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions. Methods: Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Following, 6 young, 6 middle-aged, 5 old and 5 very old rats were sacrificed for baseline myofiber dimensions and gene transcript factor expression in the soleus (SOL) and gastrocnemius (GAS). The remaining 6 young and 5 old rats were given HMB for 16 wk. and then sacrificed. Results: Fat mass increased in the middle-aged control condition (+49%) but not the middle-aged HMB condition. In addition, fat mass declined (-56%) in the old HMB condition but not the old control condition. Normalized strength declined and maintained respectively in the control and HMB conditions from 44 to 60 wk. and increased (+23%) (p < 0.05) from 86 to 102 wk. in only the HMB condition. Declines occurred in myofiber size in all muscles from 44 to 102 wk. in the control condition(-10 to -15%), but not HMB condition. Atrogin-1 mRNA expression in the SOL and GAS muscles was greater in the 102-wk control condition than all other conditions: SOL (+45%) and GAS (+100%). This elevation was blunted by HMB in the 102 wk. old SOL. There was a condition effect in the SOL for myogenin, which significantly increased (+40%) only in the 102-wk. HMB group relative to the 44-wk. group. Conclusions: HMB may blunt age-related losses of strength and myofiber dimensions, possibly through attenuating the rise in protein breakdown. C1 [Wilson, Jacob M.; Lee, Sang-Rok; Park, Young-Min; Henning, Paul C.; Arjmandi, Bahram H.; Panton, Lynn B.; Kim, Jeong-Su] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA. [Wilson, Jacob M.] Univ Tampa, Dept Hlth Sci & Human Performance, Tampa, FL 33606 USA. [Grant, Samuel C.; Masad, Ihssan S.] Florida State Univ, Natl High Magnet Field Lab, Tallahassee, FL 32306 USA. [Grant, Samuel C.; Masad, Ihssan S.] Florida State Univ, Dept Chem & Biomed Engn, Tallahassee, FL 32306 USA. [Henning, Paul C.] US Army Res, Mil Performance Div, Inst Environm Med, Natick, MA USA. [Masad, Ihssan S.] King Faisal Univ, Coll Engn, Dept Biomed Engn, Al Hasa, Saudi Arabia. [Stout, Jeffery R.] Univ Cent Florida, Coll Educ, Orlando, FL 32816 USA. [Loenneke, Jeremy P.] Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA. RP Kim, JS (reprint author), Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA. EM jkim6@fsu.edu RI Masad, Ihssan/A-8498-2013; Grant, Samuel/D-8744-2013; Stout, Jeffrey/F-5805-2014 OI Grant, Samuel/0000-0001-7738-168X; NR 62 TC 23 Z9 25 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD APR 18 PY 2012 VL 9 AR 18 DI 10.1186/1550-2783-9-18 PG 11 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 949DQ UT WOS:000304556800001 PM 22512917 ER PT J AU Miller, EH Obernosterer, G Raaben, M Herbert, AS Deffieu, MS Krishnan, A Ndungo, E Sandesara, RG Carette, JE Kuehne, AI Ruthel, G Pfeffer, SR Dye, JM Whelan, SP Brummelkamp, TR Chandran, K AF Miller, Emily Happy Obernosterer, Gregor Raaben, Matthijs Herbert, Andrew S. Deffieu, Maika S. Krishnan, Anuja Ndungo, Esther Sandesara, Rohini G. Carette, Jan E. Kuehne, Ana I. Ruthel, Gordon Pfeffer, Suzanne R. Dye, John M. Whelan, Sean P. Brummelkamp, Thijn R. Chandran, Kartik TI Ebola virus entry requires the host-programmed recognition of an intracellular receptor SO EMBO JOURNAL LA English DT Article DE Ebola virus; Marburg virus; Niemann-Pick C1; viral entry; viral receptor ID NIEMANN-PICK C1; LIPOPROTEIN-DERIVED CHOLESTEROL; LAKE-VICTORIA-MARBURGVIRUS; STEROL-SENSING DOMAIN; ZAIRE-EBOLAVIRUS; VIRAL ENTRY; CELLULAR ENTRY; DC-SIGN; GLYCOPROTEIN; BINDING AB Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified. We showed previously that Niemann-Pick C1 (NPC1), a lysosomal cholesterol transporter, is required for filovirus entry. Here, we demonstrate that NPC1 is a critical filovirus receptor. Human NPC1 fulfills a cardinal property of viral receptors: it confers susceptibility to filovirus infection when expressed in non-permissive reptilian cells. The second luminal domain of NPC1 binds directly and specifically to the viral glycoprotein, GP, and a synthetic single-pass membrane protein containing this domain has viral receptor activity. Purified NPC1 binds only to a cleaved form of GP that is generated within cells during entry, and only viruses containing cleaved GP can utilize a receptor retargeted to the cell surface. Our findings support a model in which GP cleavage by endosomal cysteine proteases unmasks the binding site for NPC1, and GP-NPC1 engagement within lysosomes promotes a late step in entry proximal to viral escape into the host cytoplasm. NPC1 is the first known viral receptor that recognizes its ligand within an intracellular compartment and not at the plasma membrane. The EMBO Journal (2012) 31, 1947-1960. doi:10.1038/emboj.2012.53; Published online 6 March 2012 Subject Categories: membranes & transport; microbiology & pathogens C1 [Herbert, Andrew S.; Kuehne, Ana I.; Ruthel, Gordon; Dye, John M.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Miller, Emily Happy; Krishnan, Anuja; Ndungo, Esther; Sandesara, Rohini G.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Obernosterer, Gregor; Brummelkamp, Thijn R.] Netherlands Canc Inst, Dept Biochem, Amsterdam, Netherlands. [Raaben, Matthijs; Whelan, Sean P.] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA USA. [Deffieu, Maika S.; Pfeffer, Suzanne R.] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA. [Carette, Jan E.] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. RP Dye, JM (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM john.m.dye1@us.army.mil; sean_whelan@hms.harvard.edu; t.brummelkamp@nki.nl; kartik.chandran@einstein.yu.edu OI Ndungo, Esther/0000-0002-9975-7032 FU NIH [R01 AI088027, AI081842, T32 GM007288, R21 HG004938]; NERCE-BEID [U54 AI057159]; DTRA [05.10.RD.005]; Ara Parseghian Medical Research Foundation FX We thank Margaret C Kielian, Max L Nibert, Vinayaka R Prasad, Steven U Walkley, and Anthony C Wong for critical reading of the manuscript and valuable advice; and T-Y Chang, DR Burton, and T Kirchhausen for their generous gifts of the WT and NPC1-null CHO cells, KZ52 antibody, and a plasmid encoding LAMP1-eGFP, respectively. This research was supported by NIH grants R01 AI088027 (to KC), AI081842 and U54 AI057159 (NERCE-BEID) (to SPW), and R21 HG004938 (to TRB); by the DTRA project, #CBM.VAXPLAT. 05.10.RD.005 (to JMD); and by the Ara Parseghian Medical Research Foundation (to SRP). EHM was additionally supported by NIH-funded training program T32 GM007288 at the Albert Einstein College of Medicine. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 55 TC 106 Z9 110 U1 3 U2 55 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0261-4189 J9 EMBO J JI Embo J. PD APR 18 PY 2012 VL 31 IS 8 BP 1947 EP 1960 DI 10.1038/emboj.2012.53 PG 14 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 930AV UT WOS:000303108600010 PM 22395071 ER PT J AU Arun, P Abu-Taleb, R Valiyaveettil, M Wang, Y Long, JB Nambiar, MP AF Arun, Peethambaran Abu-Taleb, Rania Valiyaveettil, Manojkumar Wang, Ying Long, Joseph B. Nambiar, Madhusoodana P. TI Transient changes in neuronal cell membrane permeability after blast exposure SO NEUROREPORT LA English DT Article DE blast exposure; fluorescence release; fluorescence uptake; membrane integrity; SH-SY5Y cells; traumatic brain injury ID NEUROTRAUMA AB The biochemical mechanisms of explosive blast-induced traumatic brain injury and the subsequent long-term neurobehavioral abnormalities are still not completely understood. We studied the biochemical mechanism of blast traumatic brain injury using our recently reported in-vitro model system with a shock tube. Primary blast exposure of in-vitro models leads to neurobiological changes in an overpressure dose-dependent and time-dependent manner. Lactate dehydrogenase was released significantly into the extracellular medium without cell death after blast exposure, indicating compromised cell membrane integrity. We further explored the integrity of cell membrane after blast exposure by fluorescent dye uptake/release techniques in SH-SY5Y human neuroblastoma cells. Our data indicate that blast exposure leads to an overpressure-dependent transient increase in the release of preloaded calcein AM into the culture medium with proportional intracellular decrease. Uptake of an extracellular nucleic acid-binding dye TO-PRO-3 iodide was also increased significantly after blast exposure, indicating that the increased molecular transport is bidirectional and nuclear membrane integrity is also affected by blast exposure. These results suggest that blast exposure perturbs the integrity of the neuronal cell membrane, leading to increased bidirectional transport of molecules - a potential mechanism that can lead to traumatic brain injury. NeuroReport 23:342-346 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. C1 [Arun, Peethambaran; Abu-Taleb, Rania; Valiyaveettil, Manojkumar; Wang, Ying; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU Center for Military Psychiatry and Neurosciences, Walter Reed Army Institute of Research FX Support from COL Paul Bliese, Director, Center for Military Psychiatry and Neurosciences, Walter Reed Army Institute of Research, is greatly acknowledged. NR 12 TC 11 Z9 11 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD APR 18 PY 2012 VL 23 IS 6 BP 342 EP 346 DI 10.1097/WNR.0b013e328351b58d PG 5 WC Neurosciences SC Neurosciences & Neurology GA 922CU UT WOS:000302525200002 PM 22426026 ER PT J AU Heimbeck, MS Marks, DL Brady, D Everitt, HO AF Heimbeck, M. S. Marks, D. L. Brady, D. Everitt, H. O. TI Terahertz interferometric synthetic aperture tomography for confocal imaging systems SO OPTICS LETTERS LA English DT Article ID HOLOGRAPHY; MICROSCOPY AB Terahertz (THz) interferometric synthetic aperture tomography (TISAT) for confocal imaging within extended objects is demonstrated by combining attributes of synthetic aperture radar and optical coherence tomography. Algorithms recently devised for interferometric synthetic aperture microscopy are adapted to account for the diffraction-and defocusing-induced spatially varying THz beam width characteristic of narrow depth of focus, high-resolution confocal imaging. A frequency-swept two-dimensional TISAT confocal imaging instrument rapidly achieves in-focus, diffraction-limited resolution over a depth 12 times larger than the instrument's depth of focus in a manner that may be easily extended to three dimensions and greater depths. (C) 2012 Optical Society of America C1 [Heimbeck, M. S.; Everitt, H. O.] USA, Charles M Bowden Res Ctr, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. [Marks, D. L.; Brady, D.; Everitt, H. O.] Duke Univ, Coll Dept Elect & Comp Engn, Durham, NC 27708 USA. RP Heimbeck, MS (reprint author), USA, Charles M Bowden Res Ctr, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. EM martin.heimbeck@us.army.mil RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 8 TC 7 Z9 7 U1 1 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 15 PY 2012 VL 37 IS 8 BP 1316 EP 1318 PG 3 WC Optics SC Optics GA 937MB UT WOS:000303661500011 PM 22513671 ER PT J AU Wang, K Strycker, BD Voronine, DV Jha, PK Scully, MO Meyers, RE Hemmer, P Sokolov, AV AF Wang, Kai Strycker, Benjamin D. Voronine, Dmitri V. Jha, Pankaj K. Scully, Marlan O. Meyers, Ronald E. Hemmer, Philip Sokolov, Alexei V. TI Remote sub-diffraction imaging with femtosecond laser filaments SO OPTICS LETTERS LA English DT Article ID AIR AB Achieving super-resolution has become a scientific imperative for remote imaging of objects and scenes needing increased detail and has motivated the development of various laser-based techniques. We demonstrate a scheme which achieves subdiffraction imaging of remote objects by using femtosecond laser filaments. The use of laser filaments for imaging is destined to have applications in many environments. (C) 2012 Optical Society of America C1 [Wang, Kai; Strycker, Benjamin D.; Voronine, Dmitri V.; Jha, Pankaj K.; Scully, Marlan O.; Hemmer, Philip; Sokolov, Alexei V.] Texas A&M Univ, Dept Phys & Astron, Inst Quantum Sci & Engn, College Stn, TX 77843 USA. [Scully, Marlan O.] Princeton Univ, Princeton, NJ 08544 USA. [Meyers, Ronald E.] USA, Res Lab, Adelphi, MD 20783 USA. RP Wang, K (reprint author), Texas A&M Univ, Dept Phys & Astron, Inst Quantum Sci & Engn, College Stn, TX 77843 USA. EM wangkai@physics.tamu.edu FU Army Research Office [W911NF-07-1-0475]; Office of Naval Research; Robert A. Welch Foundation [A-1261, A-1547]; Herman F. Heep and Minnie Belle Heep Texas AM University FX We thank A. M. Zheltikov for valuable discussions, and T. A. Zapata and M. Zhi for assistance in experiment. This work was supported by the Army Research Office (grant No. W911NF-07-1-0475), the Office of Naval Research, and the Robert A. Welch Foundation (grants No. A-1261 and A-1547). M. O. S. also acknowledges support from the Herman F. Heep and Minnie Belle Heep Texas A&M University Endowed Fund held/administered by the Texas A&M Foundation. NR 17 TC 6 Z9 6 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 15 PY 2012 VL 37 IS 8 BP 1343 EP 1345 PG 3 WC Optics SC Optics GA 937MB UT WOS:000303661500020 PM 22513680 ER PT J AU Ervin, MH Miller, BS Hanrahan, B Mailly, B Palacios, T AF Ervin, Matthew H. Miller, Benjamin S. Hanrahan, Brendan Mailly, Benjamin Palacios, Tomas TI A comparison of single-wall carbon nanotube electrochemical capacitor electrode fabrication methods (vol 62C, pg 37, 2012) SO ELECTROCHIMICA ACTA LA English DT Correction C1 [Ervin, Matthew H.; Miller, Benjamin S.; Hanrahan, Brendan] USA, Res Lab, Adelphi, MD 20783 USA. [Mailly, Benjamin; Palacios, Tomas] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. RP Ervin, MH (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Matthew.H.Ervin.Civ@Mail.mil NR 1 TC 0 Z9 0 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD APR 15 PY 2012 VL 67 BP 230 EP 230 DI 10.1016/j.electacta.2012.03.020 PG 1 WC Electrochemistry SC Electrochemistry GA 926OV UT WOS:000302841600035 ER PT J AU Barrow, TM Ellsworth, RE Harris, HR Barault, L Valente, A Shriver, CD Michels, KB AF Barrow, Timothy M. Ellsworth, Rachel E. Harris, Holly R. Barault, Ludovic Valente, Allyson Shriver, Craig D. Michels, Karin B. TI Loss of imprinting in PEG3, MEST and ARHI/DIRAS3 in invasive breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Barrow, Timothy M.; Harris, Holly R.; Barault, Ludovic; Michels, Karin B.] Brigham & Womens Hosp, Boston, MA 02115 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Windber, PA USA. [Valente, Allyson] Windber Res Inst, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 4039 DI 10.1158/1538-7445.AM2012-4039 PG 2 WC Oncology SC Oncology GA V43SR UT WOS:000209701605328 ER PT J AU Ellsworth, RE Rummel, S Varner, E Shriver, CD AF Ellsworth, Rachel E. Rummel, Seth Varner, Erika Shriver, Craig D. TI Evaluation of BRCA1 mutations in patients with triple negative breast cancer SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn, Windber, PA USA. [Rummel, Seth; Varner, Erika] Windber Res Inst, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 68 DI 10.1158/1538-7445.AM2012-68 PG 2 WC Oncology SC Oncology GA V43SR UT WOS:000209701605251 ER PT J AU Hale, DF Vreeland, TJ Dabney, RS Clifton, GT Sears, AK Pappou, E Anastasopoulou, E Ardavanis, A Ponniah, S Papamichail, M Perez, S Shumway, N Peoples, GE Mittendorf, E AF Hale, Diane F. Vreeland, Timothy J. Dabney, Raetasha S. Clifton, G. Travis Sears, Alan K. Pappou, Efi Anastasopoulou, Eleftheria Ardavanis, Alexandros Ponniah, Sathibalan Papamichail, Michael Perez, Sonia Shumway, Nathan Peoples, George E. Mittendorf, Elizabeth TI Immune response assessment in a phase II trial of AE37 HER2 peptide vaccine SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Hale, Diane F.; Vreeland, Timothy J.; Dabney, Raetasha S.; Clifton, G. Travis; Sears, Alan K.; Shumway, Nathan; Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Pappou, Efi; Anastasopoulou, Eleftheria; Ardavanis, Alexandros; Papamichail, Michael; Perez, Sonia] St Savas Canc Hosp, Athens, Greece. [Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Canc Vaccine Dev Lab, US Mil Canc Inst, Bethesda, MD 20814 USA. [Mittendorf, Elizabeth] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA LB-218 DI 10.1158/1538-7445.AM2012-LB-218 PG 1 WC Oncology SC Oncology GA V43SR UT WOS:000209701601436 ER PT J AU McGlynn, KA Chia, VM Trabert, B Cook, MB Quraishi, S Stanczyk, FZ Rifai, N Bradwin, G Rubertone, MV Graubard, BI Erickson, RL AF McGlynn, Katherine A. Chia, Victoria M. Trabert, Britton Cook, Michael B. Quraishi, Sabah Stanczyk, Frank Z. Rifai, Nader Bradwin, Gary Rubertone, Mark V. Graubard, Barry I. Erickson, Ralph L. TI Pre-diagnostic steroid hormone levels and risk of testicular germ cell tumors SO CANCER RESEARCH LA English DT Meeting Abstract C1 [McGlynn, Katherine A.; Chia, Victoria M.; Trabert, Britton; Cook, Michael B.; Quraishi, Sabah; Graubard, Barry I.] NCI, Bethesda, MD 20892 USA. [Stanczyk, Frank Z.] Univ So Calif, Los Angeles, CA USA. [Rifai, Nader; Bradwin, Gary] Childrens Hosp Boston, Boston, MA USA. [Rubertone, Mark V.] Dept Def Serum Repository, Silver Spring, MD USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 4468 DI 10.1158/1538-7445.AM2012-4468 PG 2 WC Oncology SC Oncology GA V43SR UT WOS:000209701603346 ER PT J AU Ruiz, C Braun, M Scheble, VJ Zellweger, T Rentsch, CA Bachmann, A Dodi, A Perner, S Sesterhenn, IA Srivastava, S Bubendorf, L AF Ruiz, Christian Braun, Martin Scheble, Veit J. Zellweger, Tobias Rentsch, Cyril A. Bachmann, Alexander Dodi, Albert Perner, Sven Sesterhenn, Isabel A. Srivastava, Shiv Bubendorf, Lukas TI Comprehensive analysis of the TMPRSS2-ERG trans location during prostate cancer progression SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ruiz, Christian; Bubendorf, Lukas] Univ Basel Hosp, Inst Pathol, CH-4031 Basel, Switzerland. [Braun, Martin; Perner, Sven] Univ Hosp Bonn, Inst Prostate Canc Res, Bonn, Germany. [Scheble, Veit J.] Univ Hosp Bonn, Inst Pathol, Bonn, Germany. [Zellweger, Tobias] Univ Tubingen Hosp, Ctr Comprehens Canc, Inst Pathol, Tubingen, Germany. [Rentsch, Cyril A.; Bachmann, Alexander] St Clara Hosp, Div Urol, Basel, Switzerland. [Dodi, Albert; Sesterhenn, Isabel A.; Srivastava, Shiv] Univ Basel Hosp, Dept Urol, CH-4031 Basel, Switzerland. Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 4562 DI 10.1158/1538-7445.AM2012-4562 PG 1 WC Oncology SC Oncology GA V43SR UT WOS:000209701601208 ER PT J AU Rummel, SK Valente, AL Kane, JL Ellsworth, DL Shriver, CD Ellsworth, RE AF Rummel, Seth K. Valente, Allyson L. Kane, Jennifer L. Ellsworth, Darrell L. Shriver, Craig D. Ellsworth, Rachel E. TI Genomic instability of the breast tumor microenvironment: Stromel alterations or technological artifact SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Rummel, Seth K.; Valente, Allyson L.; Kane, Jennifer L.; Ellsworth, Darrell L.] Windber Res Inst, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Ellsworth, Rachel E.] Henry M Jackson, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 3097 DI 10.1158/1538-7445.AM2012-3097 PG 2 WC Oncology SC Oncology GA V43SR UT WOS:000209701605183 ER PT J AU Rummel, SK Ellsworth, RE Shriver, CD AF Rummel, Seth K. Ellsworth, Rachel E. Shriver, Craig D. TI Evaluation of the association of the ABO blood group SNP rs505922 with breast cancer phenotypes SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Rummel, Seth K.] Windber Res Inst, Windber, PA USA. [Ellsworth, Rachel E.] Henry M Jackson, Windber, PA USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 2624 DI 10.1158/1538-7445.AM2012-2624 PG 1 WC Oncology SC Oncology GA V43SR UT WOS:000209701602251 ER PT J AU Sonavane, KA Clark, CA Moore-Medlin, TN Phillips, J Gill, JR Rong, XH Raley, MC Abreo, F Boudreaux, D Clifford, JL Nathan, CAO AF Sonavane, Kunal A. Clark, Cheryl A. Moore-Medlin, Tara N. Phillips, Jeffrey Gill, Jennifer Roberts Rong, Xiaohua Raley, Matthew C. Abreo, Fleurette Boudreaux, Doug Clifford, John L. Nathan, Cherie-Ann O. TI Comparing a topical-based curcumin to dietary curcumin in a skin cancer model SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Sonavane, Kunal A.; Clark, Cheryl A.; Moore-Medlin, Tara N.; Phillips, Jeffrey; Gill, Jennifer Roberts; Rong, Xiaohua; Raley, Matthew C.; Abreo, Fleurette; Nathan, Cherie-Ann O.] Louisiana State Univ Hlth, Shreveport, LA USA. [Boudreaux, Doug] Boudreauxs Specialty Compounding Pharm, Shreveport, LA USA. [Clifford, John L.] US Army Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 1595 DI 10.1158/1538-7445.AM2012-1595 PG 2 WC Oncology SC Oncology GA V43SQ UT WOS:000209701503327 ER PT J AU Trabert, B Erickson, RL Graubard, BI Stanczyk, FZ McGlynn, KA AF Trabert, Britton Erickson, Ralph L. Graubard, Barry I. Stanczyk, Frank Z. McGlynn, Katherine A. TI Pre-diagnostic gonadotropin levels and development of testicular germ cell tumors SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Trabert, Britton; Graubard, Barry I.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Stanczyk, Frank Z.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD APR 15 PY 2012 VL 72 SU 8 MA 4470 DI 10.1158/1538-7445.AM2012-4470 PG 2 WC Oncology SC Oncology GA V43SR UT WOS:000209701603368 ER PT J AU Salerno, HLS Beyer, FL Elabd, YA AF Salerno, Holly L. S. Beyer, Frederick L. Elabd, Yossef A. TI Anion exchange membranes derived from nafion precursor for the alkaline fuel cell SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE fuel cells; ionomers; membranes ID POLYMER ELECTROLYTE MEMBRANES; ANGLE X-RAY; TRANSPORT-PROPERTIES; IONOMER MEMBRANES; PERFLUOROSULFONATE IONOMERS; METHYL-METHACRYLATE; THERMAL-BEHAVIOR; ION-EXCHANGE; METHANOL; PERFORMANCE AB Robust hydroxide conducting membranes are required for long-lasting, low-cost solid alkaline fuel cells (AFCs). In this study, we synthesize Nafion-based anion exchange membranes (AEMs) via amination of the Nafion precursor membrane with 1,4-dimethylpiperazine. This initial reaction produces an AEM with covalently attached dimethylpiperazinium cations neutralized with fluoride anions, while a subsequent ion exchange reaction produces a hydroxide ion conducting membrane. These AEMs possess high thermal stability and different thermal transition temperatures compared to Nafion, while small-angle X-ray scattering reveals a similar ionic morphology. The hydroxide ion conductivity of the Nafion-based AEM is fivefold lower than the proton conductivity of Nafion at 80 degrees C and 90% relative humidity. More importantly, the hydroxide conductivity is insensitive to drying and rehydrating the membrane, which is atypical of other AEMs with quaternary ammonium cations. The high chemical and thermal stability of this hydroxide conducting Nafion-based AEM provides a promising alternative for AFCs. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011 C1 [Salerno, Holly L. S.; Elabd, Yossef A.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. [Beyer, Frederick L.] USA, Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA. RP Elabd, YA (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. EM elabd@drexel.edu RI Elabd, Yossef/G-9866-2014 OI Elabd, Yossef/0000-0002-7790-9445 FU U.S. Army Research Laboratory Materials Center of Excellence [W911NF-06-2-0013] FX This work was supported by the U.S. Army Research Laboratory Materials Center of Excellence, under grant number W911NF-06-2-0013. NR 70 TC 24 Z9 24 U1 6 U2 50 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD APR 15 PY 2012 VL 50 IS 8 BP 552 EP 562 DI 10.1002/polb.23033 PG 11 WC Polymer Science SC Polymer Science GA 901OU UT WOS:000300977500004 ER PT J AU Yang, B He, YP Irsa, J Lundgren, CA Ratchford, JB Zhao, YP AF Yang, B. He, Y. -P. Irsa, J. Lundgren, C. A. Ratchford, J. B. Zhao, Y. -P. TI Effects of composition-dependent modulus, finite concentration and boundary constraint on Li-ion diffusion and stresses in a bilayer Cu-coated Si nano-anode SO JOURNAL OF POWER SOURCES LA English DT Article DE Boundary constraint; Diffusion induced stress; Finite concentration; Lithium ion battery; Composition-dependent modulus; Stress assisted diffusion ID INTERCALATION-INDUCED STRESS; 1ST PRINCIPLES; ELECTROCHEMICAL LITHIATION; BATTERY APPLICATIONS; ELECTRODE PARTICLES; CRYSTALLINE SOLIDS; LITHIUM INSERTION; SILICON NANOWIRES; ELASTIC-MODULUS; CHARGE-TRANSFER AB During the lithiation of a Si anode from pure Si to fully lithiated alloy, the volume expands four times and modulus varies by several tens of times. Thus, the Li-ion diffusion and the stress evolution can be strongly coupled, which may play a significant role in determining the anode performance. In this work, we present a theoretical study of the fully coupled diffusion and stresses in a nonequilibrium Li-Si system by taking into account the effects of composition-dependent modulus, finite concentration, and boundary constraint. The Li-ion diffusion and induced stresses in a bilayer Cu-coated Si anode at the nanometer scale is examined to show these important effects. The transient stress-assisted diffusion problem is solved numerically by a finite difference method, whilst the stress field is obtained analytically. It is shown that the modulus variation with composition plays a mild role in the Li-ion diffusion. In order to account for the finite concentration effect, a nonlinear flux equation is introduced that describes the Li-ion diffusion over the full range of concentration from dilute to near-saturation state in a unified, symmetric manner. The finite concentration effect is significant, especially during the early delithiation process. The boundary constraint effect is found to play an intriguing role in the chemical diffusion. The bending stress results in a resisting force to Li-ion flow preventing effectively the Si anode from full lithiation. The constraint effect is significant for a wide range of Cu thickness. (C) 2012 Elsevier B.V. All rights reserved. C1 [Yang, B.] Univ Texas Arlington, Dept Mech & Aerosp Engn, Arlington, TX 76019 USA. [He, Y. -P.; Zhao, Y. -P.] Univ Georgia, Dept Phys & Astron, Athens, GA 30602 USA. [He, Y. -P.; Zhao, Y. -P.] Univ Georgia, Nanoscale Sci & Engn Ctr, Athens, GA 30602 USA. [Irsa, J.] Univ Wyoming, Dept Geol & Geophys, Laramie, WY 82071 USA. [Lundgren, C. A.; Ratchford, J. B.] USA, Res Lab, Adelphi, MD 20783 USA. RP Yang, B (reprint author), Univ Texas Arlington, Dept Mech & Aerosp Engn, Arlington, TX 76019 USA. EM boyang@uta.edu RI Yang, Bo/A-5716-2010; Zhao, Yiping/A-4968-2008; He, Yuping/F-2831-2011 FU US Army [W911NF-10-2-0107] FX This work was supported by US Army with the contract number of W911NF-10-2-0107. NR 62 TC 24 Z9 25 U1 2 U2 46 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD APR 15 PY 2012 VL 204 BP 168 EP 176 DI 10.1016/j.jpowsour.2012.01.029 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 904TM UT WOS:000301220800025 ER PT J AU Thomas, D Naughton, J Cote, C Welkos, S Manchester, M Young, JAT AF Thomas, Diane Naughton, John Cote, Christopher Welkos, Susan Manchester, Marianne Young, John A. T. TI Delayed Toxicity Associated with Soluble Anthrax Toxin Receptor Decoy-Ig Fusion Protein Treatment SO PLOS ONE LA English DT Article ID PROTECTIVE ANTIGEN; LETHAL FACTOR; MAMMALIAN-CELLS; STOICHIOMETRY; MACROPHAGES; ENDOCYTOSIS; COMPLEXES; INFECTION; KINETICS; TRIGGERS AB Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics. These agents act by binding to the receptor-interaction site on the protective antigen (PA) toxin subunit, thereby blocking toxin binding to cell surface receptors. Here we have made the surprising observation that co-administration of receptor decoy-Ig fusion proteins significantly delayed, but did not protect, rats challenged with anthrax lethal toxin. The delayed toxicity was associated with the in vivo assembly of a long-lived complex comprised of anthrax lethal toxin and the receptor decoy-Ig inhibitor. Intoxication in this system presumably results from the slow dissociation of the toxin complex from the inhibitor following their prolonged circulation. We conclude that while receptor decoy-Ig proteins represent promising candidates for the early treatment of B. anthracis infection, they may not be suitable for therapeutic use at later stages when fatal levels of toxin have already accumulated in the bloodstream. C1 [Thomas, Diane; Manchester, Marianne] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA. [Naughton, John; Young, John A. T.] Salk Inst Biol Studies, Nomis Ctr Immunobiol & Microbial Pathogenesis, La Jolla, CA 92037 USA. [Cote, Christopher; Welkos, Susan] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. RP Thomas, D (reprint author), Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA. EM mmanchester@ucsd.edu; jyoung@salk.edu FU National Institutes of Health [AI 076852]; Nomis Foundation; James B. Pendleton Charitable Trust; Defense Threat Reduction Agency JSTO-CBD [CBM.VAXBT.03.10.RD.004] FX This work was supported by National Institutes of Health grant AI 076852 (JATY and MM) and by the Nomis Foundation and the James B. Pendleton Charitable Trust (JATY). Work performed at USAMRIID was sponsored by the Defense Threat Reduction Agency JSTO-CBD as plan #CBM.VAXBT.03.10.RD.004/Medical Research/Material Command Research Plan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 6 Z9 7 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 12 PY 2012 VL 7 IS 4 AR e34611 DI 10.1371/journal.pone.0034611 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959TZ UT WOS:000305338600041 PM 22511955 ER PT J AU Chen, CC McQuaid, MJ AF Chen, Chiung-Chu McQuaid, Michael J. TI Mechanisms and Kinetics for the Thermal Decomposition of 2-Azido-N,N-Dimethylethanamine (DMAZ) SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID SET MODEL CHEMISTRY; GAUSSIAN-BASIS SETS; QUADRATIC CONFIGURATION-INTERACTION; CORRELATED MOLECULAR CALCULATIONS; METHYL AZIDE; GAS-PHASE; AB-INITIO; INTERNAL-ROTATION; ETHYL AZIDE; CONFORMATIONAL-ANALYSIS AB To gain insight into the mechanisms and kinetics of 2-azido-N,N-dimethylethanamine's (DMAZ's) thermal decomposition postulated reaction paths were simulated with ab initio and density functional theory quantum chemistry models. Four reaction types were modeled: (i) spin-allowed and spin-forbidden paths involving N-N-2 bond fission and nitrene formation, (ii) HN3 elimination with the formation of (dimethylamino)ethylene, (iii) N-N-2 bond fission with the formation of molecules with three- or four-membered heterocydic rings, and (iv) simple scission of C-H, C-N, and C-C bonds. The geometries of stationary points of the reactions were obtained with a MPWB1K/6-31+G(d,p) model. To locate and model the geometries of minimum energy intersystem crossing points for triplet nitrene formation and isomerization, unrestricted broken spin symmetry calculations were performed. Employed to model an analogous path for methyl azide's decomposition, this approach was found to yield results similar to those obtained with a CASSCF(10,8)/aug-cc-pVDZ model. Of the four reaction types studied, N-N-2 bond fissions with singlet or triplet nitrene formation were found to have the lowest barriers. Barriers for paths to cyclic products were found to be 2-4 kcal/mol higher. Kinetic rate expressions for individual paths were derived from the quantum chemistry results, and spin-allowed nitrene formation was found to be dominant at all temperatures and pressures examined. The expression 2.69 X 10(9) (s(-1))T-1.405 exp(-39.0 (kcal/mol)/RT), which was derived from QCISD(T)/6-31++G(3df,2p)//MPWB1K/6-31+G(d,p) results, was found to be representative of this reaction's gas-phase rate. Adjusted on the basis of results from self-consistent reaction field models to account for solvation by n-dodecane, the expression became 1.11 x 10(9) (s(-1))T-1.480 exp(-37.6 (kcal/mol)/RT). Utilizing this result and others derived in the study, a model of the decomposition of n-dodecane-solvated DMAZ was constructed, and it generated simulations that well-reproduce previously published measured data for the process. C1 [Chen, Chiung-Chu; McQuaid, Michael J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chen, CC (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 105 TC 8 Z9 8 U1 7 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD APR 12 PY 2012 VL 116 IS 14 BP 3561 EP 3576 DI 10.1021/jp212079f PG 16 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 923AY UT WOS:000302591600010 PM 22385257 ER PT J AU Vatamanu, J Borodin, O Bedrov, D Smith, GD AF Vatamanu, Jenel Borodin, Oleg Bedrov, Dmitry Smith, Grant D. TI Molecular Dynamics Simulation Study of the Interfacial Structure and Differential Capacitance of Alkylimidazolium Bis(trifluoromethanesulfonyl)imide [C(n)mim][TFSI] Ionic Liquids at Graphite Electrodes SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ELECTRICAL DOUBLE-LAYER; DENSITY-FUNCTIONAL THEORY; RESTRICTED PRIMITIVE MODEL; MONTE-CARLO SIMULATIONS; 2-DIMENSIONAL PERIODICITY; 3-DIMENSIONAL SYSTEMS; RAPID CALCULATION; PORE-SIZE; ELECTROCHEMICAL CAPACITORS; OXIDATIVE DECOMPOSITION AB The dependence on electrode potential of the interfacial structure and differential capacitance (DC) for 1-alkyl-3-methyimidazolium bis(trifluoromethanesulfonyl)imide ([C(n)mim][TFSI], n = 2, 4, 6, and 8) ionic liquids (IL) near basal (flat) and prismatic edge face (rough) graphite electrodes was investigated here with atomistic simulations. Overall camel-shaped DCs were observed for both surfaces. The prismatic graphite generated systematically larger capacitances than the atomically flat basal face. Although on the flat electrodes the DC is almost constant at electrode potential bellow saturation (i.e., roughly within +/- 2 V), on the prismatic edge face the DC showed large amplitude changes between minima and maxima. This trend in DC was explained from the dependence versus potential of the structure and composition of the interfacial electrolyte layer; specifically, faster counterions accumulation and ion segregation in the interfacial layer are observed for atomically corrugated electrode surfaces as compared to the flat ones. Surprisingly, the increase of the charge-neutral alkyl tail length of the cation resulted only in a small reduction in DC, indicating ions ability to rearrange/reorient charge-caring groups such that it maximizes the counterions charge near the surface. This finding shows a promising route for optimization of ions structure to achieve the desired/optimal properties of electrolyte (e.g., low melting point and viscosity) without significant reduction of energy density storage capabilities. C1 [Vatamanu, Jenel; Bedrov, Dmitry] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Bedrov, Dmitry; Smith, Grant D.] Wasatch Mol Inc, Salt Lake City, UT 84103 USA. RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 S Cent Campus Dr, Salt Lake City, UT 84112 USA. EM jenel.vatamanu@utah.edu RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012 OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608 FU Department of Energy [DE-SC0001912]; Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231] FX The authors are grateful to Department of Energy under Contract Grant DE-SC0001912 to University of Utah. This research used computational resources of the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 128 TC 63 Z9 63 U1 5 U2 85 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD APR 12 PY 2012 VL 116 IS 14 BP 7940 EP 7951 DI 10.1021/jp301399b PG 12 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 923AV UT WOS:000302591300041 ER PT J AU Brown, BK Wieczorek, L Kijak, G Lombardi, K Currier, J Wesberry, M Kappes, JC Ngauy, V Marovich, M Michael, N Ochsenbauer, C Montefiori, DC Polonis, VR AF Brown, Bruce K. Wieczorek, Lindsay Kijak, Gustavo Lombardi, Kara Currier, Jeffrey Wesberry, Maggie Kappes, John C. Ngauy, Viseth Marovich, Mary Michael, Nelson Ochsenbauer, Christina Montefiori, David C. Polonis, Victoria R. TI The Role of Natural Killer (NK) Cells and NK Cell Receptor Polymorphisms in the Assessment of HIV-1 Neutralization SO PLOS ONE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HLA CLASS-I; MONOCLONAL-ANTIBODIES; EFFECTOR-CELLS; SUBTYPE-B; VACCINE DEVELOPMENT; CANDIDATE VACCINE; MOLECULAR CLONES; BETA-CHEMOKINES; CHIMERIC VIRUS AB The importance of innate immune cells in HIV-1 pathogenesis and protection has been highlighted by the role of natural killer (NK) cells in the containment of viral replication. Use of peripheral blood mononuclear cells (PBMC) in immunologic studies provides both HIV-1 target cells (ie. CD4+ T cells), as well as anti-HIV-1 effector cells, such as NK cells. In this study, NK and other immune cell populations were analyzed in HIV-negative donor PBMC for an impact on the anti-HIV activity of polyclonal and monoclonal antibodies. NK cell percentages were significantly higher in donor PBMC that supported lower levels of viral replication. While the percentage of NK cells was not directly associated with neutralization titers, NK cell-depletion significantly diminished the antiviral antibody activity by up to three logs, and polymorphisms in NK killer immunoglobulin receptor (KIR) and Fc gamma RIIIa alleles appear to be associated with this affect. These findings demonstrate that NK cells and NK cell receptor polymorphisms may influence assessment of traditional HIV-1 neutralization in a platform where antibody is continuously present. This format appears to simultaneously assess conventional entry inhibition (neutralization) and non-neutralizing antibody-dependent HIV inhibition, which may provide the opportunity to delineate the dominant antibody function(s) in polyclonal vaccine responses. C1 [Brown, Bruce K.; Wieczorek, Lindsay; Kijak, Gustavo; Lombardi, Kara; Currier, Jeffrey; Wesberry, Maggie; Ngauy, Viseth; Marovich, Mary; Michael, Nelson; Polonis, Victoria R.] MHRP, Rockville, MD USA. [Brown, Bruce K.; Wieczorek, Lindsay; Kijak, Gustavo; Lombardi, Kara; Currier, Jeffrey; Wesberry, Maggie] Henry M Jackson Fdn, Rockville, MD USA. [Kappes, John C.; Ochsenbauer, Christina] Univ Alabama Birmingham, Birmingham, AL USA. [Ngauy, Viseth] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Marovich, Mary; Michael, Nelson; Polonis, Victoria R.] Walter Reed Army Inst Res, Rockville, MD USA. [Montefiori, David C.] Duke Univ, Durham, NC USA. RP Brown, BK (reprint author), MHRP, Rockville, MD USA. EM vpolonis@hivresearch.org FU Bill & Melinda Gates Foundation [38619]; UAB Center for HIV/AIDS Vaccine Immunology (CHAVI) [AI067854]; facilities of the Virology and Genetic Sequencing cores of the UAB Center for AIDS Research [P30-AI-27767]; Genetically Defined Microbe and Expression Core of the UAB Mucosal HIV and Immunobiology Center [R24 DK-64400]; Department of Veterans Affairs Medical Center, Research Service; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067] FX This study was supported in part by a Collaboration for AIDS Vaccine Discovery (CAVD) grant from the Bill & Melinda Gates Foundation (Grant ID: 38619), the UAB Center for HIV/AIDS Vaccine Immunology (CHAVI) (Grant ID AI067854), facilities of the Virology and Genetic Sequencing cores of the UAB Center for AIDS Research (P30-AI-27767); and the Genetically Defined Microbe and Expression Core of the UAB Mucosal HIV and Immunobiology Center (R24 DK-64400). The research was also supported by a Merit Review Award (JCK), from the Department of Veterans Affairs Medical Center, Research Service, and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 59 TC 6 Z9 6 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 11 PY 2012 VL 7 IS 4 AR e29454 DI 10.1371/journal.pone.0029454 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959TP UT WOS:000305336600001 PM 22509241 ER PT J AU Allison, MA Demas, CR Ebersole, BA Kleiss, BA Little, CD Meselhe, EA Powell, NJ Pratt, TC Vosburg, BM AF Allison, Mead A. Demas, Charles R. Ebersole, Bruce A. Kleiss, Barbara A. Little, Charles D. Meselhe, Ehab A. Powell, Nancy J. Pratt, Thad C. Vosburg, Brian M. TI A water and sediment budget for the lower Mississippi-Atchafalaya River in flood years 2008-2010: Implications for sediment discharge to the oceans and coastal restoration in Louisiana SO JOURNAL OF HYDROLOGY LA English DT Article DE Rivers; Surface water quality; Water resources; Particle-laden flows; Hydrologic cycles and budgets ID TRANSPORT; SYSTEM; HOLOCENE; FLUXES; DELTA; SHELF AB The Mississippi is the largest riverine system in North America and one of the most engineered rivers in the world. The challenges of studying the Mississippi River are due to its complex sediment-water dynamics and the multi (and often competing) uses for its resources. Flood control and navigation are primary factors that control how the river is managed. A third factor is the use of river resources, namely water and sediment, for nourishing the degrading coastal wetlands of the states of Louisiana and Mississippi. As such, these factors must be fully considered and coordinated while investigating and developing techniques to harness the sediment resources of the River for coastal restoration. This paper presents a detailed suspended sediment budget analysis for the lowermost Mississippi and Atchafalaya River systems for the flood years of 2008, 2009, and 2010. Data were derived mainly from Federal and State of Louisiana measurements of water discharge and suspended sediment load at (1) monitoring stations along the river channel and (2) boat-based measurements made during specific project studies at natural passes and man-made channel diversions. The present study was focused on flood years 2008-2010 to (1) minimize the influence on the budgets of a historical decline in sediment loads carried by the river as observed by previous investigators and (2) take advantage of recent improvements in the monitoring network. The results show that both the Mississippi and Atchafalaya distributary pathways were efficient at sequestering suspended sediments, particularly the larger (sand) size fraction. Approximately 44% of the total Mississippi + Red River suspended load (80% of the sand) reaching Old River Control structures split between the distributaries was sequestered upstream of the Gulf of Mexico by overbank storage and channel bed aggradation. Increases in bed aggradation in the Mississippi distributary are linked to a loss of stream power associated with man-made and natural exits upstream of the Gulf of Mexico. This further decreased the water and suspended sediment load reaching the deep water Gulf distributary exits in FY08-10 to 46% (water), 19% (total suspended load), and 1.4% (suspended sand). These patterns of sediment storage and delivery have major implications for channel dredging and river sediment diversions planned for Louisiana coastal restoration. (C) 2012 Elsevier B.V. All rights reserved. C1 [Allison, Mead A.] Univ Texas Austin, Inst Geophys, Austin, TX 78758 USA. [Demas, Charles R.] US Geol Survey, Louisiana Water Sci Ctr, Baton Rouge, LA 70816 USA. [Ebersole, Bruce A.; Little, Charles D.; Pratt, Thad C.] USA, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. [Kleiss, Barbara A.] USA, LCA Sci & Technol Off, Corps Engineers, Mississippi Valley Div, Vicksburg, MS 39180 USA. [Meselhe, Ehab A.] Univ Louisiana Lafayette, Dept Civil Engn, Lafayette, LA 70504 USA. [Powell, Nancy J.] USA, Corps Engineers, New Orleans, LA 70160 USA. [Vosburg, Brian M.] Louisiana Coastal Protect & Restorat Author, Baton Rouge, LA 70804 USA. RP Allison, MA (reprint author), Univ Texas Austin, Inst Geophys, 10100 Burnet Rd,R2200, Austin, TX 78758 USA. EM mallison@mail.utexas.edu RI Allison, Mead/A-7208-2010 FU Federal-State, Louisiana Coastal Area (LCA) FX Funding for this study was provided by the Federal-State, Louisiana Coastal Area (LCA) Science & Technology Program. We wish to thank the many individuals who contributed data and expertise to the completion of this study. Particular thanks go to Will Veatch, Patrick O'Brien, Cherie Price, Jim Pahl, Steve Ayres, Ed Creef, and Richie McComas. This manuscript also benefited greatly from reviews by Art Horowitz and one anonymous reviewer. NR 56 TC 57 Z9 58 U1 8 U2 81 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD APR 11 PY 2012 VL 432 BP 84 EP 97 DI 10.1016/j.jhydrol.2012.02.020 PG 14 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 927FT UT WOS:000302893200008 ER PT J AU Martin, G Grant, A D'Agostino, M AF Martin, Greg Grant, Alexandra D'Agostino, Mark TI Global health funding and economic development SO GLOBALIZATION AND HEALTH LA English DT Editorial Material DE Economic growth; GDP; Donor aid; Funding AB The impact of increased national wealth, as measured by Gross Domestic Product (GDP), on public health is widely understood, however an equally important but less well-acclaimed relationship exists between improvements in health and the growth of an economy. Communicable diseases such as HIV, TB, Malaria and the Neglected Tropical Diseases (NTDs) are impacting many of the world's poorest and most vulnerable populations, and depressing economic development. Sickness and disease has decreased the size and capabilities of the workforce through impeding access to education and suppressing foreign direct investment (FDI). There is clear evidence that by investing in health improvements a significant increase in GDP per capita can be attained in four ways: Firstly, healthier populations are more economically productive; secondly, proactive healthcare leads to decrease in many of the additive healthcare costs associated with lack of care (treating opportunistic infections in the case of HIV for example); thirdly, improved health represents a real economic and developmental outcome in-and-of itself and finally, healthcare spending capitalises on the Keynesian 'economic multiplier' effect. Continued under-investment in health and health systems represent an important threat to our future global prosperity. This editorial calls for a recognition of health as a major engine of economic growth and for commensurate investment in public health, particularly in poor countries. C1 [Martin, Greg; Grant, Alexandra] WHO, UNITAID, CH-1211 Geneva 27, Switzerland. [D'Agostino, Mark] Walter Reed Army Inst Res, Dept Clin Pharmacol & Translat Med, Expt Therapeut Branch, Silver Spring, MD 20910 USA. RP Martin, G (reprint author), WHO, UNITAID, 20 Ave Appia, CH-1211 Geneva 27, Switzerland. EM marting@unitaid.who.int NR 15 TC 6 Z9 6 U1 1 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1744-8603 J9 GLOBALIZATION HEALTH JI Global. Health PD APR 10 PY 2012 VL 8 AR 8 DI 10.1186/1744-8603-8-8 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 942HU UT WOS:000304035600001 PM 22490207 ER PT J AU Oh, DY Dang, XN Yi, HJ Allen, MA Xu, K Lee, YJ Belcher, AM AF Oh, Dahyun Dang, Xiangnan Yi, Hyunjung Allen, Mark A. Xu, Kang Lee, Yun Jung Belcher, Angela M. TI Graphene Sheets Stabilized on Genetically Engineered M13 Viral Templates as Conducting Frameworks for Hybrid Energy-Storage Materials SO SMALL LA English DT Article DE colloidal stability; conversion-reaction materials; graphene; lithium-ion batteries; M13 virus ID LITHIUM-ION BATTERIES; ANODE MATERIAL; REVERSIBLE CAPACITY; GRAPHITE OXIDE; NANOSCALE; DELIVERY; POWER C1 [Lee, Yun Jung] Hanyang Univ, Dept Energy Engn, Seoul 133791, South Korea. [Oh, Dahyun; Dang, Xiangnan; Yi, Hyunjung; Allen, Mark A.; Belcher, Angela M.] MIT, Dept Mat Sci & Engn, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Xu, Kang] USA, Electrochem Branch, Power & Energy Div, Sensor & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA. [Belcher, Angela M.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. RP Lee, YJ (reprint author), Hanyang Univ, Dept Energy Engn, Seoul 133791, South Korea. EM yjlee94@hanyang.ac.kr; belcher@mit.edu RI Dang, Xiangnan/A-1338-2013 OI Dang, Xiangnan/0000-0001-5033-3442 FU Army Research Office Institute through the Institute of Collaborative Biotechnologies (ICB); US National Science Foundation through the Materials Research Science and Engineering Center; Kwanjeong Educational Foundation; Korean Government FX This work was supported by the Army Research Office Institute through the Institute of Collaborative Biotechnologies (ICB) and US National Science Foundation through the Materials Research Science and Engineering Centers program. The authors appreciate the discussions with Prof. Gerbrand Ceder; the assistance in dispersing SWNT from Prof. Moon-Ho Ham; the XRD analysis by Dr. Scott A. Speakman; and discussions with Prof. Byungwoo Kang. DO is grateful for Kwanjeong Educational Foundation Scholarship and HY is grateful for a Korean Government Overseas Scholarship. NR 28 TC 29 Z9 30 U1 8 U2 71 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1613-6810 J9 SMALL JI Small PD APR 10 PY 2012 VL 8 IS 7 BP 1006 EP 1011 DI 10.1002/smll.201102036 PG 6 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 921IK UT WOS:000302471100010 PM 22337601 ER PT J AU Izvekov, S Rice, BM AF Izvekov, Sergei Rice, Betsy M. TI Mechanism of densification in silica glass under pressure as revealed by a bottom-up pairwise effective interaction model SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; INDUCED COORDINATION CHANGES; FORCE-FIELDS; AMORPHOUS SIO2; VITREOUS SILICA; ALPHA-QUARTZ; SYSTEMS; DENSITY; PHASE; TRANSFORMATIONS AB A new short-range pairwise numerical potential for silica is presented. The potential is derived from a single ab initio molecular dynamics (AIMD) simulation of molten silica using the force-matching method with the forces being represented numerically by piecewise functions (splines). The AIMD simulation is performed using the Born-Oppenheimer method with the generalized gradient approximation (BLYP) for the XC energy functional. The new effective potential includes a soft-repulsive shoulder to describe the interactions of oxygen ions at short separations. The new potential, despite being short-ranged and derived from single-phase data, exhibits a good transferability to silica crystalline polymorphs and amorphous silica. The importance of the O-O soft-repulsive shoulder interaction on glass densification under cold and shock compressions is assessed from MD simulations of silica glass under room and shock Hugoniot conditions, respectively. Results from these simulations indicate that the appearance of oxygen complexes (primarily pairs) interacting through soft-repulsive shoulder potential occurs at 8-10 GPa, and under cold compression conditions becomes notable at 40 GPa, essentially coinciding with the transition to a Si sixfold coordination state. An analysis of changes in system structure in compressed and shocked states reveals that the O ions interacting through the soft-repulsive shoulder potential in denser states of silica glass may create a mechanical multi-stability under elevated pressures and thus to contribute to the observed anomalous densification. [http://dx.doi.org/10.1063/1.3696865] C1 [Izvekov, Sergei; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. FU DoD; ARL FX The authors wish to thank Dr. George Gazonas, Dr. Iskander Batyrev, and Dr. Scott Weingarten for helpful comments. This research was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multi-scale Reactive Modeling of Insensitive Munitions and the ARL Director under the Director's Strategic Initiative program "Multi-scale Modeling of Non-Crystalline Ceramics (Glass)." Computing support was provided by the DoD Supercomputer Resource Center located at the Army Research Laboratory. NR 98 TC 8 Z9 8 U1 3 U2 49 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD APR 7 PY 2012 VL 136 IS 13 AR 134508 DI 10.1063/1.3696865 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 923CK UT WOS:000302596500042 PM 22482573 ER PT J AU Sirk, TW Slizoberg, YR Brennan, JK Lisal, M Andzelm, JW AF Sirk, Timothy W. Slizoberg, Yelena R. Brennan, John K. Lisal, Martin Andzelm, Jan W. TI An enhanced entangled polymer model for dissipative particle dynamics SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MOLECULAR-DYNAMICS; SPRING REPULSIONS; SIMULATIONS; MELTS; CHAINS AB We develop an alternative polymer model to capture entanglements within the dissipative particle dynamics (DPD) framework by using simplified bond-bond repulsive interactions to prevent bond crossings. We show that structural and thermodynamic properties can be improved by applying a segmental repulsive potential (SRP) that is a function of the distance between the midpoints of the segments, rather than the minimum distance between segments. The alternative approach, termed the modified segmental repulsive potential (mSRP), is shown to produce chain structures and thermodynamic properties that are similar to the softly repulsive, flexible chains of standard DPD. Parameters for the mSRP are determined from topological, structural, and thermodynamic considerations. The effectiveness of the mSRP in capturing entanglements is demonstrated by calculating the diffusion and mechanical properties of an entangled polymer melt. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3698476] C1 [Sirk, Timothy W.; Slizoberg, Yelena R.; Andzelm, Jan W.] USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD USA. [Brennan, John K.] USA, Energet Mat Sci Branch, Res Lab, Aberdeen, MD USA. RP Sirk, TW (reprint author), USA, Macromol Sci & Technol Branch, Res Lab, Aberdeen, MD USA. EM john.k.brennan.civ@mail.mil; jan.w.andzelm.civ@mail.mil RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU U.S. Army Research Laboratory Enterprise for Multi-Scale Research of Materials; U.S. Army Research Laboratory; Ministry of Education, Youth and Sports [LH12020] FX This work was funded by the U.S. Army Research Laboratory Enterprise for Multi-Scale Research of Materials. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. M.L. acknowledges support by the Ministry of Education, Youth and Sports, project LH-KONTAKT II no. LH12020. NR 28 TC 28 Z9 28 U1 2 U2 51 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD APR 7 PY 2012 VL 136 IS 13 AR 134903 DI 10.1063/1.3698476 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 923CK UT WOS:000302596500055 PM 22482586 ER PT J AU Arun, P Oguntayo, S Alamneh, Y Honnold, C Wang, Y Valiyaveettil, M Long, JB Nambiar, MP AF Arun, Peethambaran Oguntayo, Samuel Alamneh, Yonas Honnold, Cary Wang, Ying Valiyaveettil, Manojkumar Long, Joseph B. Nambiar, Madhusoodana P. TI Rapid Release of Tissue Enzymes into Blood after Blast Exposure: Potential Use as Biological Dosimeters SO PLOS ONE LA English DT Article ID TRAUMATIC BRAIN-INJURY; LITHOTRIPTER SHOCK-WAVES; EXPLOSIVE BLAST; RATS; DAMAGE; PERMEABILIZATION; OVERPRESSURE; AFGHANISTAN; MEMBRANE; PROTEINS AB Explosive blast results in multiple organ injury and polytrauma, the intensity of which varies with the nature of the exposure, orientation, environment and individual resilience. Blast overpressure alone may not precisely indicate the level of body or brain injury after blast exposure. Assessment of the extent of body injury after blast exposure is important, since polytrauma and systemic factors significantly contribute to blast-induced traumatic brain injury. We evaluated the activity of plasma enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and creatine kinase (CK) at different time points after blast exposure using a mouse model of single and repeated blast exposures to assess the severity of injury. Our data show that activities of all the enzymes in the plasma were significantly increased as early as 1 h after blast exposure. The elevated enzyme activity remained up to 6 h in an overpressure dose-dependent manner and returned close to normal levels at 24 h. Head-only blast exposure with body protection showed no increase in the enzyme activities suggesting that brain injury alone does not contribute to the systemic increase. In contrast to plasma increase, AST, ALT and LDH activity in the liver and CK in the skeletal muscle showed drastic decrease at 6 h after blast exposures. Histopathology showed mild necrosis at 6 h and severe necrosis at 24 h after blast exposures in liver and no changes in the skeletal muscle suggesting that the enzyme release from the tissue to plasma is probably triggered by transient cell membrane disruption from shockwave and not due to necrosis. Overpressure dependent transient release of tissue enzymes and elevation in the plasma after blast exposure suggest that elevated enzyme activities in the blood can be potentially used as a biological dosimeter to assess the severity of blast injury. C1 [Arun, Peethambaran; Oguntayo, Samuel; Alamneh, Yonas; Wang, Ying; Valiyaveettil, Manojkumar; Long, Joseph B.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Honnold, Cary] Walter Reed Army Inst Res, Vet Serv Program, Div Pathol, Silver Spring, MD USA. RP Arun, P (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. EM madhusoodana.nambiar@amedd.army.mil FU Congressionally Directed Medical Research Programs grant [W81XWH-08-2-0017] FX The study was supported by Congressionally Directed Medical Research Programs grant (Award Number W81XWH-08-2-0017) to JBL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 42 TC 11 Z9 11 U1 2 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD APR 6 PY 2012 VL 7 IS 4 AR e33798 DI 10.1371/journal.pone.0033798 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 955JA UT WOS:000305012700016 PM 22493674 ER PT J AU Silverman, AK Wilken, JM Sinitski, EH Neptune, RR AF Silverman, Anne K. Wilken, Jason M. Sinitski, Emily H. Neptune, Richard R. TI Whole-body angular momentum in incline and decline walking SO JOURNAL OF BIOMECHANICS LA English DT Article DE Biomechanics; Locomotion; Slope; Balance; Falls ID MUSCLE CONTRIBUTIONS; SLOPED SURFACES; SUPPORT LIMB; FALLERS; BIOMECHANICS; LOCOMOTION; RECOVERY; BALANCE; GAIT AB Angular momentum is highly regulated over the gait cycle and is important for maintaining dynamic stability and control of movement. However, little is known regarding how angular momentum is regulated on irregular surfaces, such as slopes, when the risk of falling is higher. This study examined the three-dimensional whole-body angular momentum patterns of 30 healthy subjects walking over a range of incline and decline angles. The range of angular momentum was either similar or reduced on decline surfaces and increased on incline surfaces relative to level ground, with the greatest differences occurring in the frontal and sagittal planes. These results suggest that angular momentum is more tightly controlled during decline walking when the risk of falling is greater. In the frontal plane, the range of angular momentum was strongly correlated with the peak hip and knee abduction moments in early stance. In the transverse plane, the strongest correlation occurred with the knee external rotation peak in late stance. In the sagittal plane, all external moment peaks were correlated with the range of angular momentum. The peak ankle plantarflexion, knee flexion and hip extension moments were also strongly correlated with the sagittal-plane angular momentum. These results highlight how able-bodied subjects control angular momentum differently on sloped surfaces relative to level walking and provide a baseline for comparison with pathological populations that are more susceptible to falling. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Silverman, Anne K.] Colorado Sch Mines, Dept Mech Engn, Golden, CO 80401 USA. [Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. [Sinitski, Emily H.; Neptune, Richard R.] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA. RP Silverman, AK (reprint author), Colorado Sch Mines, Dept Mech Engn, Golden, CO 80401 USA. EM asilverm@mines.edu RI Silverman, Anne/M-2727-2016; OI Silverman, Anne/0000-0002-2228-4548; Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program FX This work was supported in part by a grant from the Military Amputee Research Program (to JMW). NR 24 TC 16 Z9 16 U1 0 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD APR 5 PY 2012 VL 45 IS 6 BP 965 EP 971 DI 10.1016/j.jbiomech.2012.01.012 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 928KC UT WOS:000302980600009 PM 22325978 ER PT J AU Young, PMM Wilken, JM Dingwell, JB AF Young, Patricia M. McAndrew Wilken, Jason M. Dingwell, Jonathan B. TI Dynamic margins of stability during human walking in destabilizing environments SO JOURNAL OF BIOMECHANICS LA English DT Article DE Walking; Dynamic stability margins; Perturbations; Pseudo-random; Visual; Walking surface ID LONG-RANGE CORRELATIONS; CENTER-OF-MASS; BALANCE RECOVERY; OLDER ADULTS; GAIT; VARIABILITY; STRENGTH; MOTION; BODY; AMPUTEES AB Understanding how humans maintain stability when walking, particularly when exposed to perturbations, is key to preventing falls. Here, we quantified how imposing continuous, pseudorandom anterior-posterior (AP) and mediolateral (ML) oscillations affected the control of dynamic walking stability. Twelve subjects completed five 3-minute walking trials in the Computer Assisted Rehabilitation ENvironment (CAREN) system under each of 5 conditions: no perturbation (NOP), AP platform (APP) or visual (APV) or ML platform (MLP) or visual (MLV) oscillations. We computed AP and ML margins of stability (MOS) for each trial. Mean MOSml were consistently slightly larger during all perturbation conditions than during NOP (p <= 0.038). Mean MOSap for the APP, MLP and MLV oscillations were significantly smaller than during NOP (p < 0.0005). Variability of both MOSap and MOSml was significantly greater during the MLP and MLV oscillations than during NOP (p < 0.0005). We also directly quantified how the MOS on any given step affected the MOS on the following step using first-return plots. There were significant changes in step-to-step MOSml dynamics between experimental conditions (p < 0.0005). These changes suggested that subjects may have been trying to control foot placement, and consequently stability, during the perturbation conditions. Quantifying step-to-step changes in margins of dynamic stability may be more useful than mean MOS in assessing how individuals control walking stability. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Young, Patricia M. McAndrew] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Dingwell, JB (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. EM jdingwell@mail.utexas.edu OI Dingwell, Jonathan/0000-0001-6990-4153; Wilken, Jason/0000-0002-5556-7667 FU National Institutes of Health [1R21-EB007638, 1-R01-HD059844]; Military Amputee Research Program FX Support provided by National Institutes of Health Grants 1R21-EB007638 and 1-R01-HD059844 (to JBD) and the Military Amputee Research Program (to JMW). NR 33 TC 32 Z9 32 U1 5 U2 19 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD APR 5 PY 2012 VL 45 IS 6 BP 1053 EP 1059 DI 10.1016/j.jbiomech.2011.12.027 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 928KC UT WOS:000302980600023 PM 22326059 ER PT J AU Valiyaveettil, M Alamneh, YA Doctor, BP Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas A. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Crossroads in the evaluation of paraoxonase 1 for protection against nerve agent and organophosphate toxicity SO TOXICOLOGY LETTERS LA English DT Review DE Catalytic bioscavenger; Paraoxonase 1; Organophosphates; Chemical warfare nerve agents; Therapeutics; Combination therapy ID HUMAN SERUM PARAOXONASE; GULF-WAR VETERANS; MICROINSTILLATION INHALATION EXPOSURE; HISTONE DEACETYLASE INHIBITORS; NEUROLOGIC SYMPTOM COMPLEXES; ELEMENT-BINDING PROTEIN-2; LOW-DENSITY-LIPOPROTEIN; TRAUMATIC BRAIN-INJURY; RECEPTOR-ALPHA AGONIST; CORONARY-HEART-DISEASE AB Human paraoxonase 1 (PON1), a 45 kDa arylesterase associated with circulating high density lipoproteins (HDL), has been described as an anti-atherogenic element in cardiovascular disorders. The efficacy of PON1 as a catalytic bioscavenger against OP and CWNA toxicity has been on debate for the last few decades. Hydrolysis of various organophosphates (OPs) and chemical warfare nerve agents (CWNAs) by PON1 has been demonstrated in both in vitro and in vivo experiments. Recently, we established the protective efficacy of human and rabbit serum purified PON1 as well as human recombinant PON1 expressed in Trichoplusia ni larvae against nerve agent toxicity in guinea pigs. Exogenous administration of purified PON1 was effective in protecting against 1.2 X LCt(50) of sarin and soman administered endotracheally with microinstillation technology. However, the short half-life of exogenously administered PON1, probably due to poor association with circulating HDL, warrant alternative approaches for successful utility of PON1 in the treatment of OP/CWNA toxicity. In this mini review, we address the pros and cons of current PON1 prophylaxis and propose potential solutions for successful development of PON1 as an effective catalytic bioscavenger. Published by Elsevier Ireland Ltd. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas A.; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [1.D0017_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant #1.D0017_08_WR_C. The collaborative and technical help from Alfred M. Sciuto, Ph.D., Michael Perkins, Ph.D., and Peter Rezk at USAMRICD, Aberdeen Proving Ground, MD is greatly acknowledged. Help from Jeffrey John, WRAIR for microinstillation art work is also greatly acknowledged. NR 137 TC 6 Z9 7 U1 1 U2 24 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD APR 5 PY 2012 VL 210 IS 1 BP 87 EP 94 DI 10.1016/j.toxlet.2012.01.013 PG 8 WC Toxicology SC Toxicology GA 928ZA UT WOS:000303029800011 PM 22301377 ER PT J AU Brosten, TR Vogt, SJ Seymour, JD Codd, SL Maier, RS AF Brosten, Tyler R. Vogt, Sarah J. Seymour, Joseph D. Codd, Sarah L. Maier, Robert S. TI Preasymptotic hydrodynamic dispersion as a quantitative probe of permeability SO PHYSICAL REVIEW E LA English DT Article ID POROUS-MEDIA; FLOW; DIFFUSION AB We interpret a generalized short-time expansion of stochastic hydrodynamic dispersion dynamics in the case of small Reynolds number flow through macroscopically homogenous permeable porous media to directly determine hydrodynamic permeability. The approach allows determination of hydrodynamic permeability from pulsed field gradient spin-echo nuclear magnetic resonance measurement of the short-time effective hydrodynamic dispersion coefficient. The analytical expansion of asymptotic dynamics agrees with experimental NMR data and lattice Boltzmann simulation of hydrodynamic dispersion in consolidated random sphere pack media. C1 [Brosten, Tyler R.; Maier, Robert S.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Vogt, Sarah J.; Seymour, Joseph D.] Montana State Univ, Dept Chem & Biol Engn, Bozeman, MT 59717 USA. [Codd, Sarah L.] Montana State Univ, Dept Mech & Ind Engn, Bozeman, MT 59717 USA. RP Brosten, TR (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM tyler.brosten@usace.army.mil RI Seymour, Joseph/E-8518-2012; Codd, Sarah/F-1639-2013; Vogt, Sarah/H-1079-2013 OI Seymour, Joseph/0000-0003-4264-5416; Vogt, Sarah/0000-0002-9009-5183 NR 36 TC 4 Z9 4 U1 0 U2 12 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD APR 5 PY 2012 VL 85 IS 4 AR 045301 DI 10.1103/PhysRevE.85.045301 PN 2 PG 4 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 920NF UT WOS:000302411100001 PM 22680531 ER PT J AU Haynes, BF Gilbert, PB McElrath, MJ Zolla-Pazner, S Tomaras, GD Alam, SM Evans, DT Montefiori, DC Karnasuta, C Sutthent, R Liao, HX DeVico, AL Lewis, GK Williams, C Pinter, A Fong, Y Janes, H DeCamp, A Huang, YD Rao, M Billings, E Karasavvas, N Robb, ML Ngauy, V de Souza, MS Paris, R Ferrari, G Bailer, RT Soderberg, KA Andrews, C Berman, PW Frahm, N De Rosa, SC Alpert, MD Yates, NL Shen, XY Koup, RA Pitisuttithum, P Kaewkungwal, J Nitayaphan, S Rerks-Ngarm, S Michael, NL Kim, JH AF Haynes, Barton F. Gilbert, Peter B. McElrath, M. Juliana Zolla-Pazner, Susan Tomaras, Georgia D. Alam, S. Munir Evans, David T. Montefiori, David C. Karnasuta, Chitraporn Sutthent, Ruengpueng Liao, Hua-Xin DeVico, Anthony L. Lewis, George K. Williams, Constance Pinter, Abraham Fong, Youyi Janes, Holly DeCamp, Allan Huang, Yunda Rao, Mangala Billings, Erik Karasavvas, Nicos Robb, Merlin L. Ngauy, Viseth de Souza, Mark S. Paris, Robert Ferrari, Guido Bailer, Robert T. Soderberg, Kelly A. Andrews, Charla Berman, Phillip W. Frahm, Nicole De Rosa, Stephen C. Alpert, Michael D. Yates, Nicole L. Shen, Xiaoying Koup, Richard A. Pitisuttithum, Punnee Kaewkungwal, Jaranit Nitayaphan, Sorachai Rerks-Ngarm, Supachai Michael, Nelson L. Kim, Jerome H. TI Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS; V1/V2 DOMAIN; ANTIBODY; PROTECTION; GP120; INFECTION; RESPONSES; ENVELOPE; MONKEYS; SIV AB BACKGROUND In the RV144 trial, the estimated efficacy of a vaccine regimen against human immunodeficiency virus type 1 (HIV-1) was 31.2%. We performed a case-control analysis to identify antibody and cellular immune correlates of infection risk. METHODS In pilot studies conducted with RV144 blood samples, 17 antibody or cellular assays met prespecified criteria, of which 6 were chosen for primary analysis to determine the roles of T-cell, IgG antibody, and IgA antibody responses in the modulation of infection risk. Assays were performed on samples from 41 vaccinees who became infected and 205 uninfected vaccinees, obtained 2 weeks after final immunization, to evaluate whether immune-response variables predicted HIV-1 infection through 42 months of follow-up. RESULTS Of six primary variables, two correlated significantly with infection risk: the binding of IgG antibodies to variable regions 1 and 2 (V1V2) of HIV-1 envelope proteins (Env) correlated inversely with the rate of HIV-1 infection (estimated odds ratio, 0.57 per 1-SD increase; P = 0.02; q = 0.08), and the binding of plasma IgA antibodies to Env correlated directly with the rate of infection (estimated odds ratio, 1.54 per 1-SD increase; P = 0.03; q = 0.08). Neither low levels of V1V2 antibodies nor high levels of Env-specific IgA antibodies were associated with higher rates of infection than were found in the placebo group. Secondary analyses suggested that Env-specific IgA antibodies may mitigate the effects of potentially protective antibodies. CONCLUSIONS This immune-correlates study generated the hypotheses that V1V2 antibodies may have contributed to protection against HIV-1 infection, whereas high levels of Env-specific IgA antibodies may have mitigated the effects of protective antibodies. Vaccines that are designed to induce higher levels of V1V2 antibodies and lower levels of Env-specific IgA antibodies than are induced by the RV144 vaccine may have improved efficacy against HIV-1 infection. C1 [Haynes, Barton F.; Tomaras, Georgia D.; Alam, S. Munir; Montefiori, David C.; Liao, Hua-Xin; Ferrari, Guido; Soderberg, Kelly A.; Yates, Nicole L.; Shen, Xiaoying] Duke Univ, Human Vaccine Inst, Durham, NC 27710 USA. [Haynes, Barton F.; Tomaras, Georgia D.; Alam, S. Munir; Montefiori, David C.; Liao, Hua-Xin; Ferrari, Guido; Soderberg, Kelly A.; Yates, Nicole L.; Shen, Xiaoying] Duke Univ, Sch Med, Ctr HIV AIDS Vaccine Immunol, Durham, NC 27710 USA. [Gilbert, Peter B.; Fong, Youyi; Janes, Holly; DeCamp, Allan; Huang, Yunda] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA. [McElrath, M. Juliana; Frahm, Nicole; De Rosa, Stephen C.] Fred Hutchinson Canc Res Ctr, Div Clin Res, Vaccine & Infect Dis Div, Seattle, WA 98104 USA. [Zolla-Pazner, Susan; Williams, Constance] Vet Affairs New York Harbor Healthcare Syst, New York, NY USA. [Zolla-Pazner, Susan; Williams, Constance] NYU, Sch Med, Dept Pathol, New York, NY USA. [Evans, David T.; Alpert, Michael D.] Harvard Univ, Sch Med, New England Reg Primate Ctr, Dept Microbiol & Immunobiol, Southborough, MA 01772 USA. [Rao, Mangala; Billings, Erik; Robb, Merlin L.; Paris, Robert; Andrews, Charla; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil Res Program, Silver Spring, MD USA. [Bailer, Robert T.; Koup, Richard A.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Karnasuta, Chitraporn; Karasavvas, Nicos; Ngauy, Viseth; de Souza, Mark S.] Armed Forces Res Inst Med Sci, US Army Component, Bangkok 10400, Thailand. [Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army, Bangkok 10400, Thailand. [Sutthent, Ruengpueng] Siriraj Hosp, Dept Microbiol, Natl HIV Repository & Bioinformat Ctr, Bangkok, Thailand. [Pitisuttithum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand. [Berman, Phillip W.] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA. [DeVico, Anthony L.; Lewis, George K.] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Pinter, Abraham] Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA. RP Haynes, BF (reprint author), Duke Univ, Med Ctr, Duke Human Vaccine Inst, 2 Genome Ct,Box 103020, Durham, NC 27710 USA. EM hayne002@mc.duke.edu RI Ferrari, Guido/A-6088-2015; Tomaras, Georgia/J-5041-2016 FU Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery; U.S. Army Medical Research and Materiel Command; NIAID [Y1-AI-2642-12, U01-AI-067854]; Henry M. Jackson Foundation for the Advancement of Military Medicine; Department of Defense [W81XWH-07-2-0067]; HIV Vaccine Trials Network Laboratory [UM1-AI-068618] FX Supported in part by grants from the Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (to Drs. Haynes, Koup, and Montefiori); an interagency agreement between the U.S. Army Medical Research and Materiel Command and the NIAID (Y1-AI-2642-12); a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the Department of Defense (W81XWH-07-2-0067); and grants from the NIAID to the Center for HIV/AIDS Vaccine Immunology (U01-AI-067854) and the HIV Vaccine Trials Network Laboratory Program (UM1-AI-068618). NR 40 TC 722 Z9 740 U1 10 U2 96 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 5 PY 2012 VL 366 IS 14 BP 1275 EP 1286 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 919QJ UT WOS:000302343000005 PM 22475592 ER PT J AU Hulten, EA Pinto, G Weissman, G Fuisz, A AF Hulten, Edward A. Pinto, Geetha Weissman, Gaby Fuisz, Anthon TI Anomalous Vena Caval Return to the Left Atrium SO CIRCULATION LA English DT Editorial Material ID DRAINAGE C1 [Hulten, Edward A.] Walter Reed Army Med Ctr, Serv Cardiol, Dept Med, Washington, DC 20307 USA. [Pinto, Geetha; Weissman, Gaby; Fuisz, Anthon] Washington Hosp Ctr, Dept Med, Serv Cardiol, Washington, DC 20010 USA. RP Hulten, EA (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM eddiehulten@gmail.com OI Hulten, Edward/0000-0001-9281-0032 NR 4 TC 2 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD APR 3 PY 2012 VL 125 IS 13 BP E525 EP E528 DI 10.1161/CIRCULATIONAHA.111.019521 PG 4 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 922OS UT WOS:000302557900001 PM 22474315 ER PT J AU Aguirre, NW Tan, JG Coats, DR Spiering, BA Brown, LE Coburn, JW Rubin, DA Judelson, DA AF Aguirre, Nicholas W. Tan, Jeremy G. Coats, Daniel R. Spiering, Barry A. Brown, Lee E. Coburn, Jared W. Rubin, Daniela A. Judelson, Daniel A. TI Effect of exercise order on endocrine and metabolic responses to concurrent exercise SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Aguirre, Nicholas W.; Tan, Jeremy G.; Coats, Daniel R.; Brown, Lee E.; Coburn, Jared W.; Rubin, Daniela A.; Judelson, Daniel A.] Calif State Univ Fullerton, Fullerton, CA 92634 USA. [Spiering, Barry A.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RI Brown, Lee/A-1073-2013 OI Brown, Lee/0000-0001-6269-4616 NR 0 TC 0 Z9 0 U1 0 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711304511 ER PT J AU Barnes, JN Hart, EC Curry, TB Nicholson, WT Eisenach, JH Wallin, BG Charkoudian, N Joyner, MJ AF Barnes, Jill Nicole Hart, Emma C. Curry, Timothy B. Nicholson, Wayne T. Eisenach, John H. Wallin, B. Gunnar Charkoudian, Nisha Joyner, Michael J. TI Greater autonomic support of blood pressure in older women SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Barnes, Jill Nicole; Hart, Emma C.; Curry, Timothy B.; Nicholson, Wayne T.; Eisenach, John H.; Joyner, Michael J.] Mayo Clin, Rochester, MN USA. [Wallin, B. Gunnar] Gothenburg Univ, Sahlgren Acad, Inst Neurosci & Physiol, Gothenburg, Sweden. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711301194 ER PT J AU Biedenkapp, J Helwig, BG Leon, LR AF Biedenkapp, Joseph Helwig, Bryan G. Leon, Lisa R. TI Hypothalamic gene expression profiles during heat stroke recovery in a conscious mouse model SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Biedenkapp, Joseph] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Helwig, Bryan G.; Leon, Lisa R.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711303253 ER PT J AU Carvey, CE McGraw, SM Lieberman, HR AF Carvey, Christina E. McGraw, Susan M. Lieberman, Harris R. TI Dietary Supplements service members are using in Afghanistan and why they use them SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Carvey, Christina E.; McGraw, Susan M.; Lieberman, Harris R.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300945 ER PT J AU Crowder, TA East, WB AF Crowder, Todd A. East, Whitfield B. TI Shaping college-age eating behavior in an institutionally derived food setting with a simple, interactive computer spreadsheet SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Crowder, Todd A.; East, Whitfield B.] US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711305194 ER PT J AU Darlington, DN Gann, DS AF Darlington, Daniel N. Gann, Donald S. TI Bufodienolides in pig plasma and urine SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Darlington, Daniel N.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Gann, Donald S.] Univ Maryland, Baltimore, MD 21201 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711306969 ER PT J AU Dubick, MA Rose, R Grubbs, DL Barr, JL Klemcke, HG AF Dubick, Michael A. Rose, Rajiv Grubbs, Dana L. Barr, Johnny L. Klemcke, Harold G. TI Liver antioxidant status after hemorrhage in inbred rat strains fed diets varying in levels of methyl group donors for 9 weeks SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Dubick, Michael A.; Rose, Rajiv; Grubbs, Dana L.; Barr, Johnny L.; Klemcke, Harold G.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300528 ER PT J AU Farina, EK Austin, KG Fulgoni, VL Lieberman, HR AF Farina, Emily Kristin Austin, Krista G. Fulgoni, Victor L. Lieberman, Harris R. TI Concomitant use of dietary supplements and prescription medications among US adult civilians with a doctor-informed chronic disease: NHANES 2005-2008 SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Farina, Emily Kristin; Austin, Krista G.; Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Fulgoni, Victor L.] Nutr Impact LLC, Battle Creek, MI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300934 ER PT J AU Harvey, R Casey, DP Hart, EC Charkoudian, N Curry, TB Joyner, MJ Barnes, JN AF Harvey, Ronee Casey, Darren P. Hart, Emma C. Charkoudian, Nisha Curry, Timothy B. Joyner, Michael J. Barnes, Jill N. TI Aging and the effect of autonomic blockade on central and peripheral pulse wave velocity SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Harvey, Ronee] Mayo Clin, Coll Med, Rochester, MN USA. [Casey, Darren P.; Hart, Emma C.; Curry, Timothy B.; Joyner, Michael J.; Barnes, Jill N.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA. [Casey, Darren P.] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711301017 ER PT J AU Helwig, BG Ward, JA Leon, LR AF Helwig, Bryan G. Ward, Jermaine A. Leon, Lisa R. TI Decreased tight junction gene expression in the duodenum following heat stroke in F344 rats SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Helwig, Bryan G.; Ward, Jermaine A.; Leon, Lisa R.] USA, Inst Environm Med, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711302477 ER PT J AU Hinojosa-Laborde, C Ryan, KL Rickards, CA Convertino, VA AF Hinojosa-Laborde, Carmen Ryan, Kathy L. Rickards, Caroline A. Convertino, Victor A. TI Resting sympathetic baroreflex sensitivity in subjects with low and high tolerance to simulated hemorrhage with lower body negative pressure SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Hinojosa-Laborde, Carmen; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711301637 ER PT J AU Hoke, AV Gautam, A Filippov, A Amemiya, K Hammamieh, R Jett, M AF Hoke, Allison Violet Gautam, Aarti Filippov, Andrey Amemiya, Kei Hammamieh, Rasha Jett, Marti TI Screening of siRNA to identify the genes associated with vascular collapse when exposed to Yersinia pestis SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Hoke, Allison Violet; Gautam, Aarti; Hammamieh, Rasha; Jett, Marti] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Filippov, Andrey] Walter Reed Army Inst Res, Silver Spring, MD USA. [Amemiya, Kei] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711303174 ER PT J AU Jibitu, M Meyerhoff, J Chakraborty, N De Lima, TCM Jett, M Hammamieh, R AF Jibitu, Meskerem Meyerhoff, James Chakraborty, Nabarun Monteiro De Lima, Thereza Christina Jett, Marti Hammamieh, Rasha TI Behavioral assessments of mouse Strain differences in response to social stress SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Jibitu, Meskerem; Chakraborty, Nabarun; Jett, Marti; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. [Meyerhoff, James] Georgetown Univ, Sch Med, Dept Psychiat, Washington, DC USA. [Monteiro De Lima, Thereza Christina] Catarina Fed Univ Santa Catarina, Dept Pharmacol, Sao Paulo, Brazil. RI Lima, Thereza/C-6812-2015 OI Lima, Thereza/0000-0002-3253-7350 NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711303169 ER PT J AU Klemcke, HG DeKroon, RM Mocanu, M Robinette, JB Alzate, O AF Klemcke, Harold G. DeKroon, Robert M. Mocanu, Mihaela Robinette, Jennifer B. Alzate, Oscar TI Cardiac mitochondrial proteomic expression in inbred rat strains divergent in survival time after hemorrhage (STaH) SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Klemcke, Harold G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [DeKroon, Robert M.; Mocanu, Mihaela; Robinette, Jennifer B.; Alzate, Oscar] Univ N Carolina, Syst Prote Core Lab, Chapel Hill, NC USA. [DeKroon, Robert M.; Alzate, Oscar] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC USA. [Mocanu, Mihaela; Robinette, Jennifer B.] Univ N Carolina, Program Mol Biol & Biotechnol, Chapel Hill, NC USA. NR 0 TC 0 Z9 0 U1 8 U2 8 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300615 ER PT J AU Kluck, BN Barnes, JN Harvey, RE Curry, TB Hart, EC Charkoudian, N Joyner, MJ Casey, DP AF Kluck, Breann Nicole Barnes, Jill N. Harvey, Ronee E. Curry, Timothy B. Hart, Emma C. Charkoudian, Nisha Joyner, Michael J. Casey, Darren P. TI Higher aortic wave reflection is mediated in part by greater autonomic support in older women SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Harvey, Ronee E.] Mayo Clin, Coll Med, Rochester, MN USA. [Charkoudian, Nisha] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711301883 ER PT J AU Leon, LR Eustis, HL Urso, ML AF Leon, Lisa R. Eustis, Heather L. Urso, Maria L. TI Skeletal muscle is a potential source of cytokines during heat stroke recovery in mice SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Eustis, Heather L.; Urso, Maria L.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711301768 ER PT J AU Lutz, LJ Karl, JP Cable, SJ Williams, KW Young, AJ McClung, JP AF Lutz, Laura J. Karl, J. Philip Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Sex differences in eating behavior during military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Lutz, Laura J.; Karl, J. Philip; Young, Andrew J.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300951 ER PT J AU Margolis, LM Cao, JJ Sauter, ER Whigham, LD McClung, JP Combs, GF Young, AJ Pasiakos, SM AF Margolis, Lee M. Cao, Jay J. Sauter, Edward R. Whigham, Leah D. McClung, James P. Combs, Gerald F. Young, Andrew J. Pasiakos, Stefan M. TI A high protein diet upregulates whole-body protein turnover during energy deficit SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Margolis, Lee M.; McClung, James P.; Young, Andrew J.; Pasiakos, Stefan M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Cao, Jay J.; Whigham, Leah D.; Combs, Gerald F.] ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND USA. [Sauter, Edward R.] UND Sch Med & Hlth Sci, Grand Forks, ND USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300225 ER PT J AU McClung, JP Lutz, LJ Karl, JP Rood, JC Cable, SJ Williams, KW Pasiakos, SM Young, AJ AF McClung, James P. Lutz, Laura J. Karl, J. Philip Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. Pasiakos, Stefan M. Young, Andrew J. TI Temporal changes in serum hepcidin concentrations and iron status in male Soldiers during military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [McClung, James P.; Lutz, Laura J.; Karl, J. Philip; Pasiakos, Stefan M.; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer C.] Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Traning, Ft Jackson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300955 ER PT J AU McGivern, M Wiewel, K Borkovec, A Jett, M Mendis, C AF McGivern, Meghan Wiewel, Kurstin Borkovec, Ashley Jett, Marti Mendis, Chanaka TI Evaluating multiple signaling activities in LPS induced human peripheral blood mononuclear cells SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [McGivern, Meghan; Wiewel, Kurstin; Borkovec, Ashley; Mendis, Chanaka] Univ Wisconsin Platteville, Dept Chem & Engn Phys, Platteville, WI USA. [Jett, Marti] USA, Ctr Environm Hlth Res, US Army Med Command, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711302020 ER PT J AU Meledeo, MA Bynum, JA Sondeen, JL Bowman, PD AF Meledeo, Michael Adam Bynum, James A. Sondeen, Jill L. Bowman, Phillip D. TI Endothelial cell responses to laminar flow: changes in gene expression, protein, and glycocalyx SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Meledeo, Michael Adam; Bynum, James A.; Sondeen, Jill L.; Bowman, Phillip D.] USA, DCR, Inst Surg Res, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711303229 ER PT J AU Miller, SA Shupp, JW Moffatt, LT Rosenthal, DS Nam, J Hammamieh, R Jett, M AF Miller, Stacy-Ann Shupp, Jeffrey W. Moffatt, Lauren T. Rosenthal, Dean S. Nam, Jason Hammamieh, Rasha Jett, Marti TI High throughput transcriptomic analysis of the effects of radiation exposure in a mouse model. SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Miller, Stacy-Ann; Hammamieh, Rasha; Jett, Marti] USA, Ctr Envir Hlth Res, Ft Detrick, MD USA. [Shupp, Jeffrey W.; Moffatt, Lauren T.] Washington Hosp Ctr, Burn Ctr, Dept Surg, Washington, DC 20010 USA. [Rosenthal, Dean S.; Nam, Jason] Georgetown Univ, Dept Biochem & Mol Biol, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711302312 ER PT J AU Muderhwa, JM AF Muderhwa, Jean Mulimbi TI Formulation Development of Alcohol-Free Oil-in-Water Microemulsions as Potential Adjuvants and Vehicles for Vaccines SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Muderhwa, Jean Mulimbi] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711307061 ER PT J AU Muza, SR Jones, JE Fulco, CS Beidleman, BA Staab, JE AF Muza, Stephen Raymond Jones, Juli E. Fulco, Charles S. Beidleman, Beth A. Staab, Janet E. TI Recombinant erythropoietin administration reduces exercise-induced deline in regional cerebral oxygenation at 4500 m SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Muza, Stephen Raymond; Jones, Juli E.; Fulco, Charles S.; Beidleman, Beth A.; Staab, Janet E.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711304285 ER PT J AU Pasiakos, SM Margolis, LM Karl, JP Rood, JC Cable, SJ Williams, KW Young, AJ McClung, JP AF Pasiakos, Stefan M. Margolis, Lee M. Karl, J. Philip Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Sex differences in plasma amino acid and fat free mass responses to military training SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Pasiakos, Stefan M.; Margolis, Lee M.; Karl, J. Philip; Young, Andrew J.; McClung, James P.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300131 ER PT J AU Ray, R Andres, D Keyser, B Appell, A Benton, B Kniffin, D Hamilton, T AF Ray, Radharaman Andres, Devon Keyser, Brian Appell, Ashley Benton, Betty Kniffin, Denise Hamilton, Tracey TI Sulfur Mustard Aerosol Inhalation Injury in Rat Lungs via Fas-mediated Apoptosis SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Ray, Radharaman; Andres, Devon; Keyser, Brian; Appell, Ashley; Benton, Betty; Kniffin, Denise; Hamilton, Tracey] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711301164 ER PT J AU Rickards, C Hinojosa-Laborde, C Ryan, KL Convertino, VA AF Rickards, Caroline Hinojosa-Laborde, Carmen Ryan, Kathy L. Convertino, Victor A. TI The influence of breathing on hemodynamic oscillations at presyncope SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Rickards, Caroline] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Hinojosa-Laborde, Carmen; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711302697 ER PT J AU Rose, R Oh, T Calderon, M Klemcke, HG AF Rose, Rajiv Oh, Taesung Calderon, Mariam Klemcke, Harold G. TI Influence of dietary methyl group donors on survival time after hemorrhage in an inbred rat strain SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Rose, Rajiv; Oh, Taesung; Calderon, Mariam; Klemcke, Harold G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711300607 ER PT J AU Ryan, KL Rickards, CA Hinojosa-Laborde, C Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Hinojosa-Laborde, Carmen Convertino, Victor A. TI Time Course of Compensatory Physiological Responses to Central Hypovolemia Varies with Tolerance SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711302553 ER PT J AU Santos, WJ Melige, M Chakraborty, N Meyerhoff, J Hammamieh, R Jett, M AF Santos, William Jose Melige, Monique Chakraborty, Nabarun Meyerhoff, James Hammamieh, Rasha Jett, Marti TI Strain differences in response to stress: Territorial urine markings, body weight, and temperature SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Santos, William Jose; Melige, Monique; Chakraborty, Nabarun; Meyerhoff, James; Hammamieh, Rasha; Jett, Marti] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 3 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711304791 ER PT J AU Urow, UF Melige, M Sowe, B Chakraborty, N Carroll, E Meheroff, J Hammamieh, R Jett, M AF Urow, Umid Farach Melige, Monique Sowe, Bintu Chakraborty, Nabarun Carroll, Erica Meheroff, James Hammamieh, Rasha Jett, Marti TI Histological markers of Cardiovascular Diseases in a mouse model of social stress simulating aspects of PTSD SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Melige, Monique; Meheroff, James] USA, Ctr Environm Hlth Res, Syst Biol Dept, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711304495 ER PT J AU Uyehara, CFT Golden, PJ Ichimura, WM Murata, LAM Sato, AK Hernandez, CA AF Uyehara, Catherine F. T. Golden, Patrick J. Ichimura, Wayne M. Murata, Lee-Ann M. Sato, Aileen K. Hernandez, Claudia A. TI Renal handling of potassium in a Sus scrofa model of acute hemorrhagic shock SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Uyehara, Catherine F. T.; Golden, Patrick J.; Ichimura, Wayne M.; Murata, Lee-Ann M.; Sato, Aileen K.; Hernandez, Claudia A.] Tripler Army Med Ctr, Honolulu, HI USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711307205 ER PT J AU Waddy, E Chakraborty, N Gautam, A Santos, W Hoke, A Jett, M Hammamieh, R AF Waddy, Edward Chakraborty, Nabarun Gautam, Aarti Santos, William Hoke, Allison Jett, Marti Hammamieh, Rasha TI Pan-omic Approaches to Study the Effects of Microgravity on Host Responses to Toxins SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Waddy, Edward; Chakraborty, Nabarun; Gautam, Aarti; Santos, William; Hoke, Allison; Jett, Marti; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711305031 ER PT J AU Xu, XJ Karis, AJ Mullen, SP Patel, T Buller, MJ Santee, WR AF Xu, Xiaojiang Karis, Anthony J. Mullen, Stephen P. Patel, Tejash Buller, Mark J. Santee, William R. TI Estimating Core Temperature during Exercise in Heat Using Non-Invasive Measurements SO FASEB JOURNAL LA English DT Meeting Abstract CT Experimental Biology Meeting CY APR 21-25, 2012 CL San Diego, CA C1 [Xu, Xiaojiang; Karis, Anthony J.; Mullen, Stephen P.; Patel, Tejash; Buller, Mark J.; Santee, William R.] USA, Environm Med Res Inst, Biophys & Biomed Modelling Div, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 5 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR PY 2012 VL 26 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA 032IZ UT WOS:000310711302799 ER PT J AU Hwang, PF Ospina, KA Lee, EH Rehring, SR AF Hwang, Paul F. Ospina, Karen A. Lee, Earl H. Rehring, Scott R. TI Unconventional Management of Chyloascites After Laparoscopic Nissen Fundoplication SO JSLS-JOURNAL OF THE SOCIETY OF LAPAROENDOSCOPIC SURGEONS LA English DT Article; Proceedings Paper CT General Surgery Open Forum Presentation at the 19th Annual Meeting and Endo Expo of the Society-of-Laparoendoscopic-Surgeons (SLS) CY SEP 01-04, 2010 CL New York, NY SP Soc Laparoendoscop Surg (SLS) DE Chyloascites; Laparoscopic Nissen fundoplication; Lymphatic glue embolization ID CHYLOUS ASCITES; THORACIC-DUCT; PERCUTANEOUS CATHETERIZATION; CISTERNA CHYLI; EMBOLIZATION; CHYLOTHORAX; SOMATOSTATIN; EXPERIENCE AB Background & Objectives: Chyloascites is a rare complication that can result from abdominal trauma, neoplasm, inflammatory conditions, or various abdominal surgeries. Few cases have been described secondary to iatrogenic injury from laparoscopic Nissen fundoplication. We describe a case in which this surgery resulted in chyloascites that was successfully treated by lymphatic glue embolization. Methods: A 37-year-old male presented with signs and symptoms consistent with chronic reflux disease. He underwent an uneventful laparoscopic Nissen fundoplication. Two weeks postoperatively, he was admitted for dehydration. During his admission, he began to develop a persistent cough, shortness of breath, and abdominal distention. Imaging and fluid analysis from thoracocentesis and paracentesis were consistent with chyle leakage. Despite nonoperative measures, the patient's presentation persisted. Results: Thoracic duct ligation was performed without success. Bipedal lymphangiography identified an extensive leak revealing a severely lacerated thoracic duct spilling contrast freely into the abdomen and no contrast entering the thoracic duct in the chest. The site of injury was successfully sealed off with percutaneous glue embolization through lymph channels. Conclusion: Chyloascites is a rare complication of laparoscopic Nissen fundoplication. When not successful with conservative measures, lymphatic glue embolization can provide effective treatment. C1 [Hwang, Paul F.; Ospina, Karen A.; Lee, Earl H.; Rehring, Scott R.] Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, Washington, DC 20307 USA. [Hwang, Paul F.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Hwang, PF (reprint author), Walter Reed Army Med Ctr, Dept Surg, Gen Surg Serv, 6900 Georgia Ave NW,Bldg 2,Rm 5C28, Washington, DC 20307 USA. EM Paul.F.Hwang@us.army.mil NR 19 TC 5 Z9 6 U1 0 U2 0 PU SOC LAPAROENDOSCOPIC SURGEONS PI MIAMI PA 7330 SW 62 PL, STE 410, MIAMI, FL 33143-4825 USA SN 1086-8089 J9 JSLS-J SOC LAPAROEND JI JSLS-J. Soc. Laparoendosc. Surg. PD APR-JUN PY 2012 VL 16 IS 2 BP 301 EP 305 PG 5 WC Surgery SC Surgery GA 035EP UT WOS:000310926300021 PM 23477184 ER PT J AU Greene, MA Andres, CD AF Greene, Michael A. Andres, Craig D. TI Fire Department Attended and Unattended Fires: Estimates from the 2004-2005 National Sample Survey and Comparison with Previous Surveys SO FIRE TECHNOLOGY LA English DT Article DE Unattended fire survey; Smoke alarms; Statistical methods; National fire data ID NONFATAL INJURY RATES; SMOKE ALARMS; RECALL; PREVALENCE; CHILDREN AB Previous national surveys in 1974 and 1984 have shown that although attended and unattended fires differed substantially in severity and fire losses, there were between 10 and 29 unwanted residential fires for every fire reported to, or attended by, U. S. fire departments. The study objective was to obtain new estimates of fires not attended by fire departments. Interest in unattended fires derives from the understanding that most fires begin small, then unless controlled, grow until fire department assistance is needed. To update these analyses, a national telephone survey was conducted during 2004 and 2005. The survey had 916 respondents who reported one or more residential fires during the previous 90-day period. The principal methodological issues in analyzing the survey data included: (1) determining the optimum recall period to balance sampling variance and bias, and (2) imputing incompletely specified fire dates. The resulting estimates were 7.2 million unattended residential fires per year, a 69% decrease from the 1984 survey estimate of 22.9 million fires. During the same time period, fire department attended residential fires decreased by 36%. The greater decrease in unattended fires is at variance with the conjecture in the 1984 survey that increasing availability of smoke alarms would result in more fires detected at an earlier stage when they could be controlled by residents; a conjecture that would predict a greater decrease in attended rather than unattended fires. C1 [Greene, Michael A.] US Consumer Prod Safety Commiss, Bethesda, MD 20814 USA. [Andres, Craig D.] USA, Aberdeen Test Ctr, Aberdeen, MD 21005 USA. RP Greene, MA (reprint author), US Consumer Prod Safety Commiss, 4340 EW Highway, Bethesda, MD 20814 USA. EM michael.greene@comcast.net FU Consumer Product Safety Commission; Division of Unintentional Injury Prevention of the National Center for Injury Prevention and Control in the Centers for Disease Control and Prevention, Department of Health and Human Services; United States Fire Administration, Department of Homeland Security FX Members of the Consumer Product Safety Commission (CPSC) staff study team who contributed to this project included Linda E. Smith (retired), and William W. Zamula. Kathleen A. Stralka, Russell H. Roegner, Erlinda M. Edwards, Gregory B. Rodgers and Eileen J. Williams read drafts of this manuscript and contributed valuable suggestions. The authors also appreciate the comments of the editor and two anonymous referees. The telephone survey was conducted by Synovate, Inc. Alan Roshwalb designed the sampling plan, the sample weighting, and prepared the SAS (R) dataset used for analysis. Tim Amsbury and John Lavin were instrumental along with CPSC staff in the design of the questionnaire and supervised the data collection. The project was supervised by Corporate Vice President, W. Burleigh "Leigh" Seaver. In addition to funding from the Consumer Product Safety Commission, funding was also provided by the Division of Unintentional Injury Prevention of the National Center for Injury Prevention and Control in the Centers for Disease Control and Prevention, Department of Health and Human Services and the United States Fire Administration, Department of Homeland Security. NR 29 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0015-2684 J9 FIRE TECHNOL JI Fire Technol. PD APR PY 2012 VL 48 IS 2 BP 269 EP 289 DI 10.1007/s10694-011-0215-z PG 21 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 985EA UT WOS:000307245000007 ER PT J AU Maxwell, BD Backus, V Hohmann, MG Irvine, KM Lawrence, P Lehnhoff, EA Rew, LJ AF Maxwell, Bruce D. Backus, Vickie Hohmann, Matthew G. Irvine, Kathryn M. Lawrence, Patrick Lehnhoff, Erik A. Rew, Lisa J. TI Comparison of Transect-Based Standard and Adaptive Sampling Methods for Invasive Plant Species SO INVASIVE PLANT SCIENCE AND MANAGEMENT LA English DT Article DE Canada thistle; Cirsium arvense (L.) Scop.; Dalmatian toadflax; Linaria dalmatica (L.) P. Mill.; smooth brome; Bromus inermis Leyss.; common St. Johnswort; Hypericum perforatum L.; early detection rapid response; EDRR; nonnative plants; survey; weed mapping; exotic species; inventory; census ID STOPPING RULE; ROADS; LANDSCAPE; DESIGNS; FOREST AB Early detection of an invading nonindigenous plant species (NIS) may be critical for efficient and effective management. Adaptive survey sampling methods may provide unbiased sampling for best estimates of distribution of rare and spatially clustered populations of plants in the early stages of invasion. However, there are few examples of these methods being used for nonnative plant surveys in which travelling distances away from an initial or source patch, or away from a road or trail, can be time consuming due to the topography and vegetation. Nor is there guidance as to which of the many adaptive methods would be most appropriate as a basis for invasive plant mapping and subsequent management. Here we used an empirical complete census of four invader species in early to middle stages of invasion in a management area to assess the effectiveness and efficiency of three nonadaptive methods, four adaptive cluster methods, and four adaptive web sampling methods that all originated from transects. The adaptive methods generally sampled more NIS-occupied cells and patches than standard transect approaches. Sampling along roads only was time-efficient and effective, but only for species with restricted distribution along the roads. When populations were more patchy and dispersed over the landscape the adaptive cluster starting at the road generally proved to be the most time-efficient and effective NIS detection method. C1 [Maxwell, Bruce D.; Backus, Vickie; Lawrence, Patrick; Lehnhoff, Erik A.; Rew, Lisa J.] Montana State Univ, Dept Land Resources & Environm Sci, Bozeman, MT 59717 USA. [Hohmann, Matthew G.] USA, Corps Engineers, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Irvine, Kathryn M.] Montana State Univ, Dept Math Sci, Bozeman, MT 59717 USA. RP Maxwell, BD (reprint author), Montana State Univ, Dept Land Resources & Environm Sci, Bozeman, MT 59717 USA. EM bmax@montana.edu FU U.S. Army Corps of Engineers Engineering Research and Development Center; Construction Engineering Research Laboratory [W9132T-09-2-0012] FX Funding was from the U.S. Army Corps of Engineers Engineering Research and Development Center, Construction Engineering Research Laboratory grant W9132T-09-2-0012. Thanks to Little Bighorn Battlefield National Monument for supply of research site and plant distribution data. NR 35 TC 5 Z9 5 U1 7 U2 51 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 1939-7291 EI 1939-747X J9 INVAS PLANT SCI MANA JI Invasive Plant Sci. Manag. PD APR-JUN PY 2012 VL 5 IS 2 BP 178 EP 193 DI 10.1614/IPSM-D-11-00022.1 PG 16 WC Plant Sciences SC Plant Sciences GA 967AZ UT WOS:000305879800006 ER PT J AU Hu, H Chung, JN Amber, SH AF Hu, Hong Chung, Jacob N. Amber, Samuel H. TI An experimental study on flow patterns and heat transfer characteristics during cryogenic chilldown in a vertical pipe SO CRYOGENICS LA English DT Article DE Cryogenics; Quenching; Flow boiling; Heat transfer ID LARGE HADRON COLLIDER; REDUCED GRAVITY; TUBE; REGIMES AB In the present paper, the experimental results of a cryogenic chilldown process are reported. The physical phenomena involve unsteady two-phase vapor-liquid flow and intense boiling heat transfer of the cryogenic fluid that is coupled with the transient heat conduction inside pipe walls. The objective for the present study is to compare the chilldown rates and flow patterns between the upward flow and downward flow in a vertical pipe. Liquid nitrogen is employed as the working fluid and the test section is a vertical straight segment of a Pyrex glass pipe with an inner diameter of 8 mm. The effects of mass flow rate on the flow patterns, heat transfer characteristics and interface movement were determined through experiments performed under several different mass flow rates. Through flow visualization, measurement and analysis on the flow patterns and temperature variations, a physical explanation of the vertical chilldown is given. By observing the process and analyzing the results, it is concluded that pipe chilldown in a vertical flow is similar to that in microgravity to some extent. (c) 2012 Elsevier Ltd. All rights reserved. C1 [Hu, Hong; Chung, Jacob N.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Amber, Samuel H.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10928 USA. RP Hu, H (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM hydrogen@ufl.edu NR 26 TC 10 Z9 10 U1 2 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0011-2275 J9 CRYOGENICS JI Cryogenics PD APR-JUN PY 2012 VL 52 IS 4-6 SI SI BP 268 EP 277 DI 10.1016/j.cryogenics.2012.01.033 PG 10 WC Thermodynamics; Physics, Applied SC Thermodynamics; Physics GA 961UX UT WOS:000305496100025 ER PT J AU Sottilare, RA Proctor, M AF Sottilare, Robert A. Proctor, Michael TI Passively Classifying Student Mood and Performance within Intelligent Tutors SO EDUCATIONAL TECHNOLOGY & SOCIETY LA English DT Article DE Adaptive tutoring system; Mood; Affect; One-to-one tutoring; Passive measures ID MODEL AB It has been long recognized that successful human tutors are capable of adapting instruction to mitigate barriers (e.g., withdrawal or frustration) to learning during the one-to-one tutoring process. A significant part of the success of human tutors is based on their perception of student affect (e.g., mood or emotions). To at least match the capabilities of human tutors, computer-based intelligent tutoring system (ITS) will need to "perceive" student affect and improve performance by selecting more effective instructional strategies (e.g., feedback). To date, ITS have fallen short in realizing this capability. Much of the existing research models the emotions of virtual characters rather than assessing the affective state of the student. Our goal was to determine the context and importance of student mood in an adaptable ITS model. To enhance our existing model, we evaluated procedural reasoning systems used in virtual characters, and reviewed behavioral and physiological sensing methods and predictive models of affect. Our experiment focused on passive capture of behaviors (e.g., mouse movement) during training to predict the student's mood. The idea of mood as a constant during training and predictors of performance are also discussed. C1 [Sottilare, Robert A.] USA, Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. [Proctor, Michael] Univ Cent Florida Coll, Dept Ind Engn & Management Syst IEMS, Orlando, FL 32816 USA. RP Sottilare, RA (reprint author), USA, Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. EM robert.sottilare@us.army.mil; mproctor@mail.ucf.edu OI Sottilare, Robert/0000-0002-5278-2441 NR 42 TC 9 Z9 10 U1 0 U2 5 PU IEEE COMPUTER SOC, LEARNING TECHNOLOGY TASK FORCE PI PALMERSTON NORTH PA BAG 11-222, MASSEY UNIVERSITY, PALMERSTON NORTH, NEW ZEALAND SN 1436-4522 J9 EDUC TECHNOL SOC JI Educ. Technol. Soc. PD APR PY 2012 VL 15 IS 2 BP 101 EP 114 PG 14 WC Education & Educational Research SC Education & Educational Research GA 956CW UT WOS:000305068400010 ER PT J AU Tewari, P Kealey, CP Bennett, DB Bajwa, N Barnett, KS Singh, RS Culjat, MO Stojadinovic, A Grundfest, WS Taylor, ZD AF Tewari, Priyamvada Kealey, Colin P. Bennett, David B. Bajwa, Neha Barnett, Kelli S. Singh, Rahul S. Culjat, Martin O. Stojadinovic, Alexander Grundfest, Warren S. Taylor, Zachary D. TI In vivo terahertz imaging of rat skin burns SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE biomedical optics; medical imaging; reflection; terahertz; tissues ID TECHNOLOGY; MODEL AB A reflective, pulsed terahertz (THz) imaging system was used to acquire high-resolution (d(10-90)/lambda similar to 1.925) images of deep, partial thickness burns in a live rat. The rat's abdomen was burned with a brass brand heated to similar to 220 degrees C and pressed against the skin with contact pressure for similar to 10 sec. The burn injury was imaged beneath a Mylar window every 15 to 30 min for up to 7 h. Initial images display an increase in local water concentration of the burned skin as evidenced by a marked increase in THz reflectivity, and this likely correlates to the post-injury inflammatory response. After similar to 1 h the area of increased reflectivity consolidated to the region of skin that had direct contact with the brand. Additionally, a low reflecting ring of tissue could be observed surrounding the highly reflective burned tissue. We hypothesize that these regions of increased and decreased reflectivity correlate to the zones of coagulation and stasis that are the classic foundation of burn wound histopathology. While further investigations are necessary to confirm this hypothesis, if true, it likely represents the first in vivo THz images of these pathologic zones and may represent a significant step forward in clinical application of THz technology. (C) 2012 Society or Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.4.040503] C1 [Tewari, Priyamvada; Bajwa, Neha; Singh, Rahul S.; Culjat, Martin O.; Grundfest, Warren S.; Taylor, Zachary D.] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA. [Kealey, Colin P.; Singh, Rahul S.; Culjat, Martin O.; Grundfest, Warren S.] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA. [Bennett, David B.; Grundfest, Warren S.] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA. [Barnett, Kelli S.] Univ Calif Los Angeles, Div Lab Anim Med, Los Angeles, CA 90095 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Taylor, ZD (reprint author), Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA. EM zdeis@seas.ucla.edu FU National Science Foundation NSF [ECCS-0801897]; Henry M. Jackson Foundation [708961] FX This work was sponsored by the National Science Foundation NSF, grant #ECCS-0801897, and the Henry M. Jackson Foundation, grant #708961. NR 16 TC 18 Z9 20 U1 4 U2 31 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 J9 J BIOMED OPT JI J. Biomed. Opt. PD APR PY 2012 VL 17 IS 4 AR 040503 DI 10.1117/1.JBO.17.4.040503 PG 3 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 946UL UT WOS:000304382900003 PM 22559669 ER PT J AU Diehl, DL Siddiqui, AA Stavropoulos, SN Kowalski, TE Nguyen, VNH Hashem, HJ AF Diehl, David L. Siddiqui, Ali A. Stavropoulos, Stavros N. Kowalski, Thomas E. Nguyen, Viet-Nhan H. Hashem, Hashem J. TI Fully Covered Self-Expanding Metal Stents for Remodeling of Refractory Pancreatic Duct Strictures: A Multicenter Experience SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract CT Digestive Disease Week (DDW) CY MAY 19-22, 2012 CL San Diego, CA C1 [Diehl, David L.; Hashem, Hashem J.] Geisinger Med Ctr, Danville, PA 17822 USA. [Siddiqui, Ali A.; Kowalski, Thomas E.] Thomas Jefferson Sch Med, Philadelphia, PA USA. [Stavropoulos, Stavros N.] Winthrop Med Ctr, Mineola, NY USA. [Nguyen, Viet-Nhan H.] Womack Army Med Ctr, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD APR PY 2012 VL 75 IS 4 SU S BP 318 EP 319 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 946CU UT WOS:000304328001422 ER PT J AU Chandra, N Gupta, R AF Chandra, Namas Gupta, Raj TI Shock loading-induced Traumatic Brain Injuries in animal models-experimental and computational studies SO BRAIN INJURY LA English DT Meeting Abstract C1 [Chandra, Namas; Gupta, Raj] Univ Nebraska, Lincoln, NE USA. USA, Med Res & Mat Command, Ft Deterick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD APR-MAY PY 2012 VL 26 IS 4-5 MA 0230 BP 415 EP 415 PG 1 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 943EZ UT WOS:000304104600199 ER PT J AU Mondello, S Gabrielli, A Catani, S D'Ippolito, M Seaney, JM Schmid, K Tortella, F Wang, K Hayes, R Formisano, R AF Mondello, Stefania Gabrielli, Andrea Catani, Sheila D'Ippolito, Mariagrazia Seaney, Jixiang Mo Schmid, Kara Tortella, Frank Wang, Kevin Hayes, Ronald Formisano, Rita TI Serum MAP-2 levels at 6 months after Severe Traumatic Brain Injury Correlate with Outcome SO BRAIN INJURY LA English DT Meeting Abstract C1 [Mondello, Stefania; Gabrielli, Andrea; Tortella, Frank; Wang, Kevin; Hayes, Ronald; Formisano, Rita] Univ Florida, Gainesville, FL USA. [Seaney, Jixiang Mo] Banyan Biomarkers Inc, Alachua, FL USA. [Catani, Sheila; D'Ippolito, Mariagrazia] Santa Lucia Fdn, Rome, Italy. [Schmid, Kara] Walter Reed Army Inst Res, Silver Spring, MD USA. RI Mondello, Stefania/A-1813-2012 OI Mondello, Stefania/0000-0002-8587-3614 NR 0 TC 0 Z9 0 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD APR-MAY PY 2012 VL 26 IS 4-5 MA 0781 BP 718 EP 718 PG 1 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 943EZ UT WOS:000304104600725 ER PT J AU Dretsch, M Thiel, K Irvin, C Athy, J Crynen, G Chaytow, H Iverson, G Crawford, F AF Dretsch, Michael Thiel, Kenneth Irvin, Clinton Athy, Jeremy Crynen, Gogce Chaytow, Helena Iverson, Grant Crawford, Fiona TI Assessing the Relationship Between Neurocognitive Functioning and Mild Traumatic Brain Injury in the US Warfighter: The Contribution of Combat Exposure, Genetics, and Psychological Health SO BRAIN INJURY LA English DT Meeting Abstract C1 [Dretsch, Michael; Thiel, Kenneth; Irvin, Clinton; Athy, Jeremy] USA, Aeromed Res Lab, Ft Rucker, AL USA. [Crynen, Gogce; Chaytow, Helena; Crawford, Fiona] Roskamp Inst, Sarasota, FL USA. [Iverson, Grant] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD APR-MAY PY 2012 VL 26 IS 4-5 MA 0812 BP 736 EP 737 PG 2 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 943EZ UT WOS:000304104600755 ER PT J AU Petrie, J Gray, D Viehland, D Sreenivasulu, G Srinivasan, G Mandal, S Edelstein, AS AF Petrie, Jonathan Gray, David Viehland, Dwight Sreenivasulu, Gollapudi Srinivasan, Gopalan Mandal, Sanjay Edelstein, Alan S. TI Shifting the operating frequency of magnetoelectric sensors SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 56th Annual Conference on Magnetism and Magnetic Materials CY OCT 30-30, 2011 CL Scottsdale, AZ ID LAMINATE COMPOSITES; FIELD SENSORS AB A method is presented for increasing the operating frequency of symmetric and asymmetric magnetoelectric (ME) sensors so that the operating frequency can be equal to the mechanical resonance frequency of the sensor. This increase improves the signal to noise ratio of a symmetric sensor by at least two orders of magnitude because it mitigates the effect of 1/f noise and the sensor has an increased response at its resonant frequency. The method is based on the strong, nonlinear magnetic field dependence of the magnetostriction. Our method has lowered the detection limit to 4 pT/root Hz at 1 Hz in a magnetically unshielded environment. (C) 2012 American Institute of Physics. [doi:10.1063/1.3677840] C1 [Petrie, Jonathan; Edelstein, Alan S.] USA, Res Lab, Adelphi, MD 20783 USA. [Gray, David; Viehland, Dwight] Virginia Tech, Blacksburg, VA 24061 USA. [Sreenivasulu, Gollapudi; Srinivasan, Gopalan; Mandal, Sanjay] Oakland Univ, Rochester, MI 48309 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM alan.s.edelstein.civ@mail.mil OI Gollapudi, Sreenivasulu/0000-0002-6136-7119 FU DARPA FX We gratefully acknowledge the support of DARPA through the Heterostructure Uncooled Magnetic Sensors (HUMS) program. NR 15 TC 6 Z9 6 U1 0 U2 31 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD APR 1 PY 2012 VL 111 IS 7 AR 07C714 DI 10.1063/1.3677840 PG 3 WC Physics, Applied SC Physics GA 932HX UT WOS:000303282401078 ER PT J AU Huang, YM Mathis, WN Wilkerson, RC AF Huang, Yiau-Min Mathis, Wayne N. Wilkerson, Richard C. TI SUBGENERIC POSITION OF AEDES DUFOURI HAMON WITH NOTES ON THE SUBGENUS LEVUA STONE AND BOHART (DIPTERA: CULICIDAE) SO PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF WASHINGTON LA English DT Article DE Aedes (Levua) geoskusea (=suvae); Afrotropical Region; characterization; classification; dufouri group; Levua; Ochlerotatus; Reunion ID ALLIED TAXA DIPTERA; LIFE STAGES; MORPHOLOGICAL DATA; AEDINI DIPTERA; CLASSIFICATION; PHYLOGENY; OCHLEROTATUS AB Aedes dufouri Hamon, heretofore placed in the subgenus Levua Stone and Bohart, is transferred back to the subgenus Ochlerotatus Lynch Arribalzaga, where it is placed in a new monotypic lineage, the dufouri group, based on a morphological assessment of characters of specimens, including the type species, Aedes (Levua) suvae Stone and Bohart, 1944, from Suva, Fiji. Aedes fryeri (Theobald) was previously removed from the subgenus Levua (Huang et al. 2010). Thus, no members of the subgenus Levua (genus Aedes Meigen) are now known to occur in the Afrotropical Region. The female and the male genitalia of Ae. dufouri are redescribed and illustrated, and the dufouri group is diagnosed. Some morphological characters of adult males and females, as well as larvae, of the subgenera Ochlerotatus and Levua (genus Aedes Meigen) are tabulated. C1 [Huang, Yiau-Min; Mathis, Wayne N.] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA. [Wilkerson, Richard C.] Smithsonian Inst, WRBU, Museum Support Ctr, Suitland, MD 20746 USA. [Wilkerson, Richard C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Huang, YM (reprint author), Smithsonian Inst, Dept Entomol, POB 37012,MSC C1109,MRC 534, Washington, DC 20013 USA. EM huangy@si.edu; mathisw@si.edu; wilkersonr@si.edu FU Walter Reed Biosystematics Unit (WRBU) FX We express our sincere appreciation and gratitude to the Walter Reed Biosystematics Unit (WRBU) for providing funding for the publication; to Dr. Leopoldo M. Rueda, Walter Reed Biosystematics Unit (WRBU), and Dr. Maria Anice Mureb Sallum, University of Sao Paulo, Sao Paulo, Brazil, for critically reviewing this manuscript and for their valuable comments; to Drs. Raymond J. Gagne and Alexander Konstantinov, Research Entomologists, Systematic Entomology Laboratory, U. S. Department of Agriculture, for translating French and Russian. NR 16 TC 1 Z9 1 U1 0 U2 2 PU ENTOMOL SOC WASHINGTON PI WASHINGTON PA SMITHSONIAN INSTITUTION DEPT ENTOMOLOGY, WASHINGTON, DC 20560 USA SN 0013-8797 J9 P ENTOMOL SOC WASH JI Proc. Entomol. Soc. Wash. PD APR PY 2012 VL 114 IS 2 BP 194 EP 204 DI 10.4289/0013-8797.114.2.194 PG 11 WC Entomology SC Entomology GA 942DP UT WOS:000304022800003 ER PT J AU Dumas, JE BrownBaer, PB Prieto, EM Guda, T Hale, RG Wenke, JC Guelcher, SA AF Dumas, Jerald E. BrownBaer, Pamela B. Prieto, Edna M. Guda, Teja Hale, Robert G. Wenke, Joseph C. Guelcher, Scott A. TI Injectable reactive biocomposites for bone healing in critical-size rabbit calvarial defects SO BIOMEDICAL MATERIALS LA English DT Article ID MORPHOGENETIC PROTEIN-2 RHBMP-2; BETA-TRICALCIUM PHOSPHATE; CRANIOFACIAL SURGERY; ENDOTHELIAL-CELLS; MEMBRANOUS BONE; SOFT-TISSUE; REGENERATION; RECONSTRUCTION; MODEL; CRANIOPLASTY AB Craniofacial injuries can result from trauma, tumor ablation, or infection and may require multiple surgical revisions. To address the challenges associated with treating craniofacial bone defects, an ideal material should have the ability to fit complex defects (i.e. be conformable), provide temporary protection to the brain until the bone heals, and enhance tissue regeneration with the delivery of biologics. In this study, we evaluated the ability of injectable lysine-derived polyurethane (PUR)/allograft biocomposites to promote bone healing in critical-size rabbit calvarial defects. The biocomposites exhibited favorable injectability, characterized by a low yield stress to initiate flow of the material and a high initial viscosity to minimize the adverse phenomena of extravasation and filter pressing. After injection, the materials cured within 10-12 min to form a tough, elastomeric solid that maintained mechanical integrity during the healing process. When injected into a critical-size calvarial defect in rabbits, the biocomposites supported ingrowth of new bone. The addition of 80 mu g mL(-1) recombinant human bone morphogenetic protein-2 (rhBMP-2) enhanced new bone formation in the interior of the defect, as well as bridging of the defect with new bone. These observations suggest that injectable reactive PUR/allograft biocomposites are a promising approach for healing calvarial defects by providing both mechanical stability as well as local delivery of rhBMP-2. C1 [Dumas, Jerald E.; Prieto, Edna M.; Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Dumas, Jerald E.; Prieto, Edna M.; Guelcher, Scott A.] Vanderbilt Univ, Med Ctr, Ctr Bone Biol, Nashville, TN USA. [BrownBaer, Pamela B.; Guda, Teja; Hale, Robert G.; Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Guda, Teja] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX USA. [Guelcher, Scott A.] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA. RP Guelcher, SA (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, 2301 Vanderbilt Pl, Nashville, TN 37235 USA. EM scott.guelcher@vanderbilt.edu RI Guda, Teja/A-7286-2009; OI Guda, Teja/0000-0002-3218-2916; Brown Baer, Pamela/0000-0001-6964-1955 FU Armed Forces Institute of Regenerative Medicine (AFIRM); U.S. Army Institute of Surgical Research; National Science Foundation [DMR0847711]; U.S. Army Medical Research and Materiel Command; U.S. Navy, Office of Naval Research; U.S. Air Force, Office of the Surgeon General; National Institutes of Health; Veterans Administration; Department of Defense, USA Medical Research Acquisition (ACQ) Activity [W81XWH-08-2-0034] FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. This work was supported by the Armed Forces Institute of Regenerative Medicine (AFIRM), the U.S. Army Institute of Surgical Research, and the National Science Foundation through a CAREER award to SAG (DMR0847711). The Armed Forces Institute of Regenerative Medicine (AFIRM) is managed and funded through the U.S. Army Medical Research and Materiel Command, with additional funding from the U.S. Navy, Office of Naval Research; the U.S. Air Force, Office of the Surgeon General; the National Institutes of Health; the Veterans Administration; and local public and private matching funding. Rutgers-Cleveland Clinic Consortium of AFIRM is funded by Department of Defense, USA Medical Research Acquisition (ACQ) Activity contract no W81XWH-08-2-0034. NR 63 TC 18 Z9 19 U1 0 U2 20 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1748-6041 J9 BIOMED MATER JI Biomed. Mater. PD APR PY 2012 VL 7 IS 2 SI SI AR 024112 DI 10.1088/1748-6041/7/2/024112 PG 14 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 937OV UT WOS:000303668700013 PM 22456057 ER PT J AU Tordesillas, A Shi, JY Peters, JF AF Tordesillas, Antoinette Shi, Jingyu Peters, John F. TI Isostaticity in Cosserat continuum SO GRANULAR MATTER LA English DT Article DE Isostaticity; Cosserat; Granular; Force chains ID GRANULAR-MATERIALS; SYSTEMS; EVOLUTION; STRESSES AB Under conditions of isostaticity in granular media, the contact forces for all particles are statically determinate and forces can be computed without recourse to deformation equations or constitutive relationships. Given that stresses represent spatial averages of inter-particle forces, the stress-equilibrium equations for the isostatic state form a hyperbolic system of partial differential equations that describe the internal stress state using only boundary tractions. In this paper, we consider a Cosserat medium and propose closure relationships in terms of stresses and couple stresses from observations of stress variations in the critical state regime from discrete element simulations and experiments on sand, even though the isostatic condition is only satisfied in an average sense. It is shown that the governing equations are hyperbolic, which can be solved using the method of characteristics. Examples of both analytic and numerical solutions are presented. These examples clearly demonstrate that stress chains (characteristic lines) form oblique angles with the assumed direction of the force chains. C1 [Tordesillas, Antoinette; Shi, Jingyu] Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, Australia. [Peters, John F.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shi, JY (reprint author), Univ Melbourne, Dept Math & Stat, Parkville, Vic 3010, Australia. EM atordesi@ms.unimelb.edu.au RI Shi, Jingyu/J-3451-2016 OI Shi, Jingyu/0000-0002-5312-4854 FU Australian Research Council ARC [DP0986876]; US Army Research Office [W911NF-07-1-0370, W911NF-11-1-0175]; Melbourne Energy Institute FX We acknowledge the support of the Australian Research Council ARC (DP0986876), the US Army Research Office (W911NF-07-1-0370 & W911NF-11-1-0175) and the Melbourne Energy Institute. AT thanks Raphael Blumenfeld for suggesting an investigation of potential isostatic conditions inside shear bands. NR 20 TC 7 Z9 7 U1 0 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1434-5021 J9 GRANUL MATTER JI Granul. Matter PD APR PY 2012 VL 14 IS 2 SI SI BP 295 EP 301 DI 10.1007/s10035-012-0341-4 PG 7 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied SC Materials Science; Mechanics; Physics GA 940IJ UT WOS:000303882900038 ER PT J AU Warren, TK Shurtleff, AC Bavari, S AF Warren, Travis K. Shurtleff, Amy C. Bavari, Sina TI Advanced morpholino oligomers: A novel approach to antiviral therapy SO ANTIVIRAL RESEARCH LA English DT Review DE Antisense; Morpholino; Phosphorodiamidate; Biodefense; Ebola virus; Marburg virus ID SYNDROME VIRUS-REPLICATION; PEPTIDE NUCLEIC-ACID; EBOLA-VIRUS; CELL-CULTURES; ANTISENSE OLIGOMERS; POSTEXPOSURE PROTECTION; FLAVIVIRUS INFECTIONS; SUBCELLULAR EXTRACTS; RNA INTERFERENCE; MARBURG VIRUS AB Phosphorodiamidate morpholino oligomers (PMOs) are synthetic antisense oligonucleotide analogs that are designed to interfere with translational processes by forming base-pair duplexes with specific RNA sequences. Positively charged PMOs (PMOplus (TM)) are effective for the postexposure protection of two fulminant viral diseases, Ebola and Marburg hemorrhagic fever in nonhuman primates, and this class of antisense agent may also have possibilities for treatment of other viral diseases. PMOs are highly stable, are effective by a variety of routes of administration, can be readily formulated in common isotonic delivery vehicles, and can be rapidly designed and synthesized. These are properties which may make PMOs good candidates for use during responses to emerging or reemerging viruses that may be insensitive to available therapies or for use during outbreaks, especially in regions that lack a modern medical infrastructure. While the efficacy of sequence-specific therapies can be limited by target-site sequence variations that occur between variants or by the emergence of resistant mutants during infections, various PMO design strategies can minimize these impacts. These strategies include the use of promiscuous bases such as inosine to compensate for predicted base-pair mismatches, the use of sequences that target conserved sites between viral strains, and the use of sequences that target host products that viruses utilize for infection. (c) 2012 Elsevier B.V. All rights reserved. C1 [Warren, Travis K.; Shurtleff, Amy C.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21769 USA. RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21769 USA. EM sina.bavari@amedd.army.mil FU US Defense Threat Reduction Agency; Transformational Medical Technologies [W9113 M-10-C-0056] FX The authors thank Dr. James C. Burnett for providing the structural figures presented in Fig. 2. Support for this work has been provided by the US Defense Threat Reduction Agency and by Transformational Medical Technologies (W9113 M-10-C-0056). NR 79 TC 21 Z9 22 U1 1 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD APR PY 2012 VL 94 IS 1 BP 80 EP 88 DI 10.1016/j.antivira1.2012.02.004 PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 936VS UT WOS:000303618700011 PM 22353544 ER PT J AU Weinstein, SA Stiles, BG AF Weinstein, Scott A. Stiles, Bradley G. TI Recent perspectives in the diagnosis and evidence-based treatment of Mycoplasma genitalium SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE antibiotic resistance; detection; evidence-based management; Mycoplasma genitalium ID PELVIC-INFLAMMATORY-DISEASE; REAL-TIME PCR; CHLAMYDIA-TRACHOMATIS INFECTION; POLYMERASE-CHAIN-REACTION; FEMALE SEX WORKERS; NONGONOCOCCAL URETHRITIS; NEISSERIA-GONORRHOEAE; UREAPLASMA-UREALYTICUM; MACROLIDE RESISTANCE; MEDIATED AMPLIFICATION AB Mycoplasma genitalium is a globally important sexually transmitted pathogen. Men infected with M. genitalium frequently present with dysuria, while women may present with or without urogenital symptoms. In some populations, M. genitalium is significantly associated with HIV-1 infection, and is also an etiological agent in pelvic inflammatory disease. However, there is insufficient evidence to establish a causative role of the organism in obstetric complications, including tubal factor infertility. Although several nucleic acid amplification tests offer rapid, sensitive methods for detecting M. genitalium, there is no standardized assay. Available evidence supports treatment of M. genitalium infections with an extended regimen of azithromycin and resistant strains respond to moxifloxacin. Accumulating evidence indicates growing fluoroquinolone resistance, including against moxifloxacin, emphasizing the need for new therapeutic strategies to treat M. genitalium infections. C1 [Weinstein, Scott A.] Womens & Childrens Hosp, Adelaide, SA, Australia. [Stiles, Bradley G.] USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Frederick, MD USA. [Stiles, Bradley G.] Wilson Coll, Chambersburg, PA USA. RP Weinstein, SA (reprint author), Womens & Childrens Hosp, Adelaide, SA, Australia. EM herptoxmed@msn.com NR 130 TC 8 Z9 8 U1 0 U2 13 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD APR PY 2012 VL 10 IS 4 BP 487 EP 499 DI 10.1586/ERI.12.20 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 937AF UT WOS:000303630700015 PM 22512757 ER PT J AU Wambeke, BW Liu, M Hsiang, SM AF Wambeke, Brad W. Liu, Min Hsiang, Simon M. TI Using Last Planner and a Risk Assessment Matrix to Reduce Variation in Mechanical Related Construction Tasks SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article DE Variation; Labor productivity; Construction; Risk; Last planner ID PRODUCTIVITY; PERFORMANCE; PRINCIPLE AB Variation, defined for this research as the time difference between what was planned and what actually happened, is important as it can affect the productivity performance of construction tasks. The construction process is complex and consists of a large number of interdependent tasks. When the starting time and/or duration of one task varies, it can affect other downstream tasks and result in disruptions to the schedule and/or decreased productivity. This research examined the effect of using a risk assessment matrix in conjunction with the Last Planner System (LPS) method to reduce and/or eliminate task duration variation. A case study was conducted involving a mechanical contractor who specializes in plumbing, heating, ventilation, and air conditioning. The company compared the performance of two separate, but similar projects. The LPS method was used with one of the projects and the company's traditional planning system was used with the other (i.e., not using the LPS system). A total of 16 weeks' worth of data was collected for each project. Variation, productivity, and cost savings were analyzed using a risk assessment matrix and benefit-cost procedures. The project that used the LPS method had a 35% higher productivity performance than the traditionally planned project and resulted in a benefit-cost ratio of 13:1. The research findings fill a gap in the body of knowledge by analyzing how planning can reduce variation with real project data. The results of this research illustrate the effect the LPS method can have on reducing variation and improving project productivity performance. The findings also serve as an example of an effective planning strategy for project managers and field managers in their efforts to improve project performance. DOI: 10.1061/(ASCE)CO.1943-7862.0000444. (C) 2012 American Society of Civil Engineers. C1 [Wambeke, Brad W.; Liu, Min] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Wambeke, Brad W.] USA, West Point, NY 10996 USA. [Wambeke, Brad W.] Dept Civil & Mech Engn, West Point, NY 10996 USA. [Hsiang, Simon M.] Texas Tech Univ, Dept Ind Engn, Lubbock, TX 79409 USA. RP Liu, M (reprint author), N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. EM brad.wambeke@us.army.mil; min_liu@ncsu.edu; simon.hsiang@ttu.edu NR 18 TC 5 Z9 6 U1 2 U2 15 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD APR PY 2012 VL 138 IS 4 BP 491 EP 498 DI 10.1061/(ASCE)CO.1943-7862.0000444 PG 8 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA 927YR UT WOS:000302947100003 ER PT J AU Ford-Green, J Isayev, O Gorb, L Perkins, EJ Leszczynski, J AF Ford-Green, Jason Isayev, Olexandr Gorb, Leonid Perkins, Edward J. Leszczynski, Jerzy TI Evaluation of natural and nitramine binding energies to 3-D models of the S1S2 domains in the N-methyl-D-aspartate receptor SO JOURNAL OF MOLECULAR MODELING LA English DT Article DE Homology modeling; Molecular dynamics; Molecular docking; NMDAR; RDX; HMX ID NMDA-RECEPTOR; GLUTAMATE RECEPTORS; S-NITROSYLATION; ORAL-EXPOSURE; SUBUNITS; RDX; INHIBITION; MODULATION; MECHANISMS; EXPRESSION AB Overactivation of the N-methyl-D-aspartate receptor (NMDAR) in postsynaptic neurons leads to glutamate-related excitotoxicity in the central nervous system of mammals. We have built 3-D models of each domain for the universal screening of potential toxicants and their binding mechanisms. Our docking results show that the calculated pK(i) values of glycine and L-glutamate significantly increase (>1) when the NR1 and NR2A S1S2 domains are closing, respectively. Inversely, D-cycloserine (DCS) and 5,7-dichlorokynurenic acid (5,7-DCKA) do not show such a dependence on domain closure. Replica exchange molecular dynamics (REMD) confirmed 5 different conformational states of the S1S2 domain along the 308.2 K temperature trajectory. Analysis of residue fluctuations during this temperature trajectory showed that residues in loop 1, loop 2, the amino terminal domain (ATD), and the area linked to ion channel alpha-helices are involved in this movement. This further implicates the notion that efficacious ligands act through S1S2 lobe movement which can culminate in the opening or closing of the ion channel. We further tested this by docking hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocane (HMX) to the S1S2 domain. Our results predict that these nitramines are not efficacious and thus do not produce excitoxicity when they bind to the S1S2 domain of the NMDAR. C1 [Ford-Green, Jason; Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Ford-Green, Jason; Perkins, Edward J.; Leszczynski, Jerzy] USA, Environm Lab, ERDC, Vicksburg, MS 39180 USA. [Isayev, Olexandr] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA. [Gorb, Leonid] Badger Tech Serv, San Antonio, TX 78216 USA. RP Ford-Green, J (reprint author), Jackson State Univ, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jgreen@icnanotox.org; Edward.j.Perkins@usace.army.mil OI Isayev, Olexandr/0000-0001-7581-8497 FU United States Army Corps of Engineers by the US Army ERDC; [W912HZ-09-C-0026] FX The authors would like to thank Jacques Reifmann and the rest of his group at The Biotechnology High Performance Computing Software Application Institute (BHSAI) for their generous allotment of time, and the Army Research Laboratory (ARL) for the use of their computational resources. This work has been done under grant number W912HZ-09-C-0026. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the US Army ERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 52 TC 0 Z9 0 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1610-2940 J9 J MOL MODEL JI J. Mol. Model. PD APR PY 2012 VL 18 IS 4 BP 1273 EP 1284 DI 10.1007/s00894-011-1152-y PG 12 WC Biochemistry & Molecular Biology; Biophysics; Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Chemistry; Computer Science GA 935SM UT WOS:000303540700003 PM 21735122 ER PT J AU Grujicic, M Bell, WC Pandurangan, B Cheeseman, BA Patel, P Dehmer, PG AF Grujicic, M. Bell, W. C. Pandurangan, B. Cheeseman, B. A. Patel, P. Dehmer, P. G. TI Effect of the tin- versus air-side plate-glass orientation on the impact response and penetration resistance of a laminated transparent armour structure SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS LA English DT Article DE Borofloat (R) glass; material modelling; impact resistance; tin-side versus air-side ID BALLISTIC MATERIAL MODEL; BRITTLE MATERIALS; FLOAT GLASS; FRAGMENTATION; DAMAGE; STRENGTH AB Our recently developed continuum-level, physically based, high strain-rate, large-strain, high-pressure mechanical material model for soda-lime glass has been enhanced to include differences in the flaw-size population between the so-called air-side and the so called tin-side of float-glass plates, and adapted for use in the case of borosilicate glass. The model was structured in such a way that it is suitable for direct incorporation, as a material user-subroutine, into standard commercial transient non-linear dynamics finite-element-based software packages. The model was parameterized using various open-literature sources. The experimental portion of the work, which consisted of 28 projectile impacts onto glass/polyurethane/polycarbonate-based test laminates, was intended to allow for quantification of the effect of air-versus tin-side borofloat strike surface when incorporated into a multi-layer, multi-functional test laminate. Experimental findings indicated the lack of a significant difference in the impact resistance of air-versus tin-side test laminate strike surfaces. Subsequent to these findings, computational simulations were carried out in order to establish if the proposed borofloat material model could capture the prominent experimentally observed damage modes and the measured V50, reconfirming the experimental findings. In general, a good agreement was found between the computational and the experimental results. C1 [Grujicic, M.; Bell, W. C.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Patel, P.; Dehmer, P. G.] USA, Survivabil Mat Branch, Res Lab, Aberdeen Proving Ground, MD USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu FU US Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; Army Research Office (ARO) [W911NF-09-1-0513] FX The material presented in this paper is based on the work supported by the US Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042, and by the Army Research Office (ARO) research contract entitled Multi-length Scale Material Model Development for Armor-grade Composites, Contract Number W911NF-09-1-0513. NR 22 TC 8 Z9 8 U1 0 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1464-4207 J9 P I MECH ENG L-J MAT JI Proc. Inst. Mech. Eng. Pt. L-J. Mater.-Design Appl. PD APR PY 2012 VL 226 IS L2 BP 119 EP 143 DI 10.1177/1464420711433991 PG 25 WC Materials Science, Multidisciplinary SC Materials Science GA 935DE UT WOS:000303498300004 ER PT J AU Blaine, KE Phillips, DJ Frenzen, CL Scandrett, C Haegel, NM AF Blaine, K. E. Phillips, D. J. Frenzen, C. L. Scandrett, C. Haegel, N. M. TI Three-dimensional transport imaging for the spatially resolved determination of carrier diffusion length in bulk materials SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID LIFETIME AB A contact-free optical technique is developed to enable a spatially resolved measurement of minority carrier diffusion length and the associated mobility-lifetime (mu tau) product in bulk semiconductor materials. A scanning electron microscope is used in combination with an internal optical microscope and imaging charge-coupled device (CCD) to image the bulk luminescence from minority carrier recombination associated with one-dimensional excess carrier generation. Using a Green's function to model steady-state minority carrier diffusion in a three-dimensional half space, non-linear least squares analysis is then applied to extract values of carrier diffusion length and surface recombination velocity. The approach enables measurement of spatial variations in the mu tau product with a high degree of spatial resolution. [http://dx.doi.org/10.1063/1.3698090] C1 [Blaine, K. E.] US Mil Acad, Dept Math, West Point, NY 10996 USA. [Phillips, D. J.; Haegel, N. M.] USN, Postgrad Sch, Dept Phys, Monterey, CA 93943 USA. [Frenzen, C. L.; Scandrett, C.] USN, Postgrad Sch, Dept Appl Math, Monterey, CA 93943 USA. RP Blaine, KE (reprint author), US Mil Acad, Dept Math, West Point, NY 10996 USA. FU Academic Research Initiative (ARI) of DHS [HSHQDC-11-X-0015] FX This work was supported by the Academic Research Initiative (ARI) of DHS through Interagency Agreement HSHQDC-11-X-0015. The graphic in Figure 2 was created by J. Adeff. NR 13 TC 3 Z9 3 U1 0 U2 15 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD APR PY 2012 VL 83 IS 4 AR 043702 DI 10.1063/1.3698090 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 934BO UT WOS:000303415300027 PM 22559534 ER PT J AU Zander, NE Orlicki, JA Rawlett, AM Beebe, TP AF Zander, Nicole E. Orlicki, Joshua A. Rawlett, Adam M. Beebe, Thomas P., Jr. TI Quantification of Protein Incorporated into Electrospun Polycaprolactone Tissue Engineering Scaffolds SO ACS APPLIED MATERIALS & INTERFACES LA English DT Article DE electrospinning; nanofibers; nerve regeneration; protein quantification; protein coverage; XPS ID NEURITE OUTGROWTH; STEM-CELLS; NANOFIBERS; LAMININ; GRADIENTS; SURFACE; FIBERS; GROWTH; IMMOBILIZATION; ENHANCEMENT AB The surface modification of synthetic tissue engineering scaffolds is essential to improving their hydrophilicity and cellular compatibility. Plasma treatment is an effective way to increase the hydrophilicity of a surface, but the incorporation of biomolecules is also important to control cellular adhesion and differentiation, among many other outcomes. In this work, oriented polycaprolactone (PCL) electrospun fibers were modified by air-plasma treatment, followed by the covalent attachment of laminin. The amount of protein incorporated onto the fiber surface was controlled by varying the reaction time and the protein solution concentration. The protein concentration and coverage were quantified using X-ray photoelectron spectroscopy (XPS), solid-state ultraviolet visible spectroscopy (UV-vis) and two fluorescence-based assays. XPS results showed a nearly linear increase in protein coverage with increasing protein soaking, solution concentration until a monolayer was formed. Results from XPS and the NanoOrange fluorescence assay revealed multilayer protein coverage at protein solution concentrations between 25 and 50 mu g/mL, whereas the UV-vis assay demonstrated multilayer coverage at lower protein solution concentrations. The effect of protein concentration on the neurite outgrowth of neuron-like PC12 cells was evaluated, and outgrowth rates were found to be positively correlated to increasing protein concentration. C1 [Zander, Nicole E.; Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Zander, Nicole E.; Beebe, Thomas P., Jr.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Zander, NE (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.e.zander.civ@mail.mil NR 35 TC 28 Z9 28 U1 6 U2 60 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1944-8244 J9 ACS APPL MATER INTER JI ACS Appl. Mater. Interfaces PD APR PY 2012 VL 4 IS 4 BP 2074 EP 2081 DI 10.1021/am300045y PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 930LC UT WOS:000303139900028 PM 22409446 ER PT J AU Sun, HM Tawa, G Wallqvist, A AF Sun, Hongmao Tawa, Gregory Wallqvist, Anders TI Classification of scaffold-hopping approaches SO DRUG DISCOVERY TODAY LA English DT Review ID CAMBRIDGE STRUCTURAL DATABASE; ANGIOTENSIN-II; RECEPTOR ANTAGONISTS; BIOLOGICAL-ACTIVITIES; DRUG DISCOVERY; COMBINATORIAL LIBRARIES; SIMILARITY SEARCHES; MEDICINAL CHEMISTRY; KINASE INHIBITORS; CRYSTAL-STRUCTURE AB The general goal of drug discovery is to identify novel compounds that are active against a preselected biological target with acceptable pharmacological properties defined by marketed drugs. Scaffold hopping has been widely applied by medicinal chemists to discover equipotent compounds with novel backbones that have improved properties. In this article we classify scaffold hopping into four major categories, namely heterocycle replacements, ring opening or closure, peptidomimetics and topology-based hopping. We review the structural diversity of original and final scaffolds with respect to each category. We discuss the advantages and limitations of small, medium and large-step scaffold hopping. Finally, we summarize software that is frequently used to facilitate different kinds of scaffold-hopping methods. C1 [Sun, Hongmao; Tawa, Gregory; Wallqvist, Anders] US Army Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Frederick, MD 21702 USA. RP Sun, HM (reprint author), NIH, NIH Ctr Translat Therapeut, 9800 Med Ctr Dr, Bethesda, MD 20892 USA. EM hongmao.sun@nih.gov OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T]; Department of Defense Biotechnology High Performance Computing Software Applications Institute FX Funding of this research was provided by the U.S. Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T and the Department of Defense Biotechnology High Performance Computing Software Applications Institute. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. NR 120 TC 62 Z9 62 U1 5 U2 44 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-6446 J9 DRUG DISCOV TODAY JI Drug Discov. Today PD APR PY 2012 VL 17 IS 7-8 BP 310 EP 324 DI 10.1016/j.drudis.2011.10.024 PG 15 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 929XV UT WOS:000303099900006 PM 22056715 ER PT J AU Mahanonda, R Sa-Ard-Iam, N Rerkyen, P Thitithanyanont, A Subbalekha, K Pichyangkul, S AF Mahanonda, Rangsini Sa-Ard-Iam, Noppadol Rerkyen, Pimprapa Thitithanyanont, Arunee Subbalekha, Keskanya Pichyangkul, Sathit TI MxA expression induced by a-defensin in healthy human periodontal tissue SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE a-defensin; Homeostasis; MxA; Periodontal tissue ID LEUKOCYTE PROTEASE INHIBITOR; HUMAN GINGIVAL FIBROBLASTS; TOLL-LIKE RECEPTORS; INDUCIBLE GENE-I; ANTIMICROBIAL PEPTIDES; EPITHELIAL-CELLS; HUMAN SALIVA; INTERLEUKIN-8 EXPRESSION; ANTIVIRAL ACTIVITY; DENDRITIC CELLS AB Although periodontal tissue is continually challenged by microbial plaque, it is generally maintained in a healthy state. To understand the basis for this, we investigated innate antiviral immunity in human periodontal tissue. The expression of mRNA encoding different antiviral proteins, myxovirus resistance A (MxA), protein kinase R (PKR), oligoadenylate synthetase (OAS), and secretory leukocyte protease inhibitor (SLPI) were detected in both healthy tissue and that with periodontitis. Immunostaining data consistently showed higher MxA protein expression in the epithelial layer of healthy gingiva as compared with tissue with periodontitis. Human MxA is thought to be induced by type I and III interferons (IFNs) but neither cytokine type was detected in healthy periodontal tissues. Treatment in vitro of primary human gingival epithelial cells (HGECs) with a-defensins, but not with the antimicrobial peptides beta-defensins or LL-37, led to MxA protein expression. a-defensin was also detected in healthy periodontal tissue. In addition, MxA in a-defensin-treated HGECs was associated with protection against avian influenza H5N1 infection and silencing of the MxA gene using MxA-targeted-siRNA abolished this antiviral activity. To our knowledge, this is the first study to uncover a novel pathway of human MxA induction, which is initiated by an endogenous antimicrobial peptide, namely a-defensin. This pathway may play an important role in the first line of antiviral defense in periodontal tissue. C1 [Mahanonda, Rangsini] Chulalongkorn Univ, Fac Dent, Dept Periodontol, Bangkok, Thailand. [Mahanonda, Rangsini; Sa-Ard-Iam, Noppadol; Rerkyen, Pimprapa] Chulalongkorn Univ, Fac Dent, Res Unit Periodontal Dis, Immunol Lab, Bangkok, Thailand. [Thitithanyanont, Arunee] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand. [Subbalekha, Keskanya] Chulalongkorn Univ, Fac Dent, Dept Oral Maxillofacial Surg, Bangkok, Thailand. [Pichyangkul, Sathit] AFRIMS, Dept Immunol & Med, US Army Med Component, Bangkok, Thailand. RP Mahanonda, R (reprint author), Chulalongkorn Univ, Fac Dent, Dept Periodontol, Bangkok, Thailand. EM rangsini.m@chula.ac.th FU Thailand Research Fund [BRG5380011]; Chulalongkorn University; Ratchadapisek endowment FX This work was supported by BRG5380011 from Thailand Research Fund, Chulalongkorn University, and Ratchadapisek endowment. The authors thank S. Wiboon-ut (Department of Microbiology, Faculty of Science, Mahidol University) for technical assistance with avian influenza H5N1 experiments. We also thank Dr. C. Champaiboon for tissue sample collection, P. Ekchariyawat for STAT1 activation experiment, and Dr. K. Torrungruang for valuable comments and suggestions. NR 50 TC 5 Z9 5 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD APR PY 2012 VL 42 IS 4 BP 946 EP 956 DI 10.1002/eji.201141657 PG 11 WC Immunology SC Immunology GA 930RU UT WOS:000303157600017 PM 22531919 ER PT J AU Wildman, JL Shuffler, ML Lazzara, EH Fiore, SM Burke, CS Salas, E Garven, S AF Wildman, Jessica L. Shuffler, Marissa L. Lazzara, Elizabeth H. Fiore, Stephen M. Burke, C. Shawn Salas, Eduardo Garven, Sena TI Trust Development in Swift Starting Action Teams: A Multilevel Framework SO GROUP & ORGANIZATION MANAGEMENT LA English DT Article DE teams; theory; trust ID CONFLICT-MANAGEMENT; IMPRESSION-FORMATION; INTERPERSONAL-TRUST; GROUP COHESION; WORK TEAMS; PERFORMANCE; DIVERSITY; TASK; ORGANIZATIONS; METAANALYSIS AB Swift starting action teams (STATs) are increasingly prevalent in organizations, and the development of trust is often a critical issue for their effectiveness. However, current theory and research do not provide a clear picture regarding how trust toward the team (i.e., the team as the target) is developed in these settings. The primary contribution of this article is to present a theoretical framework describing how individual-level trust toward one's team is developed in STAT contexts. This article integrates several existing trust theories into one comprehensive context-specific multilevel theory of how trust develops in STATs from cognitive, affective, behavioral, and contextual perspectives. This framework furthers our understanding of the unique antecedents of initial trust in STATs, how trust attitudes are adjusted over the short amount of time the team interacts, and how the team context influences this developmental process. C1 [Burke, C. Shawn; Salas, Eduardo] Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, Orlando, FL 32826 USA. [Garven, Sena] USA, Res Inst, Ft Leavenworth, KS USA. [Fiore, Stephen M.] Univ Cent Florida, Cognit Sci Program, Dept Philosophy, Orlando, FL 32826 USA. [Garven, Sena] USA, Res Inst Behav & Social Sci, Ft Leavenworth Kansas Res Unit, Ft Leavenworth, KS USA. RP Salas, E (reprint author), Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM esalas@ist.ucf.edu OI Wildman, Jessica/0000-0002-0004-595X; Fiore, Stephen/0000-0003-3529-1322 NR 97 TC 25 Z9 26 U1 11 U2 54 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1059-6011 EI 1552-3993 J9 GROUP ORGAN MANAGE JI Group Organ. Manage. PD APR PY 2012 VL 37 IS 2 BP 137 EP 170 DI 10.1177/1059601111434202 PG 34 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 931RR UT WOS:000303237500002 ER PT J AU De Lorenzo, RA Morris, MJ Williams, JB Haley, TF Straight, TM Holbrook-Emmons, VL Medina, JS AF De Lorenzo, Robert A. Morris, Michael J. Williams, Justin B. Haley, Timothy F. Straight, Timothy M. Holbrook-Emmons, Victoria L. Medina, Juanita S. TI DOES A SIMPLE BEDSIDE SONOGRAPHIC MEASUREMENT OF THE INFERIOR VENA CAVA CORRELATE TO CENTRAL VENOUS PRESSURE? SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article; Proceedings Paper CT 40th Annual Scientific Meeting of the Society-for-Academic-Emergency-Medicine CY JUN 03-06, 2010 CL Phoenix, AZ SP Soc Acad Emergency Med DE central venous pressure; ultrasonography; bedside; inferior vena cava; shock; focused assessment by sonography for trauma ID RIGHT ATRIAL PRESSURE; FLUID RESPONSIVENESS; DIAMETER; ULTRASOUND; ECHOCARDIOGRAPHY; HEMODIALYSIS; COLLAPSE; WEIGHT; TRAUMA; MARKER AB Background: Bedside ultrasound has been suggested as a non-invasive modality to estimate central venous pressure (CVP). Objective: Evaluate a simple bedside ultrasound technique to measure the diameter of the inferior vena cava (IVC) and correlate to simultaneously measured CVP. Secondary comparisons include anatomic location, probe orientation, and phase of respiration. Methods: An unblinded prospective observation study was performed in an emergency department and critical care unit. Subjects were a convenience sample of adult patients with a central line at the superior venocaval-atrial junction. Ultrasound measured transverse and longitudinal diameters of the IVC at the subxiphoid, suprailiac, and mid-abdomen, each measured at end-inspiration and end-expiration. Correlation and regression analysis were used to relate CVP and IVC diameters. Results: There were 72 subjects with a mean age of 67 years (range 21 94 years), 37 (53%) male, enrolled over 9 months. Seven subjects were excluded for tricuspid valvulopathy. Primary diagnoses were: respiratory failure 12 (18%), sepsis 11 (17%), and pancreatitis 3 (5%). There were 28 (43%) patients mechanically ventilated. Adequate measurements were obtainable in 57 (89%) using the subxiphoid, in 44 (68%) using the mid-abdomen, and in 28 (43%) using the suprailiac views. The correlation coefficients were statistically significant at 0.49 (95% confidence interval [CI] 0.26 0.66), 0.51 (95% CI 0.23 0.71), and 0.50 (95% CI 0.14 0.74) for end-inspiratory longitudinal subxiphoid, midpoint, and suprailiac views, respectively. Transverse values were statistically significant at 0.42 (95% CI 0.18 0.61), 0.38 (95% CI 0.09 0.61), and 0.67 (95% CI 0.40 0.84), respectively. End-expiratory measurements gave similar or slightly less significant values. Conclusion: The subxiphoid was the most reliably viewed of the three anatomic locations; however, the suprailiac view produced superior correlations to the CVP. Longitudinal views generally outperformed transverse views. A simple ultrasound measure of the IVC yields weak correlation to the CVP. Published by Elsevier Inc. C1 [De Lorenzo, Robert A.] Brooke Army Med Ctr, MCHE CI, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.; Williams, Justin B.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [De Lorenzo, Robert A.; Morris, Michael J.; Haley, Timothy F.; Straight, Timothy M.] Univ Texas Hlth Sci Ctr San Antonio, Masters Degree Program Clin Invest, San Antonio, TX 78229 USA. [Morris, Michael J.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. RP De Lorenzo, RA (reprint author), Brooke Army Med Ctr, MCHE CI, Dept Clin Invest, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 45 TC 13 Z9 13 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD APR PY 2012 VL 42 IS 4 BP 429 EP 436 DI 10.1016/j.jemermed.2011.05.082 PG 8 WC Emergency Medicine SC Emergency Medicine GA 931ND UT WOS:000303225700011 PM 22197199 ER PT J AU Hjelkrem, M Morales, A Williams, C Harrison, SA AF Hjelkrem, M. Morales, A. Williams, C. Harrison, S. A. TI GILBERT'S SYNDROME AND NASH: A PROTECTIVE EFFECT OF UNCONJUGATED HYPERBILIRUBINEMIA SO JOURNAL OF HEPATOLOGY LA English DT Meeting Abstract CT 47th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL) CY APR 18-22, 2012 CL Barcelona, SPAIN SP European Assoc Study Liver (EASL) C1 [Hjelkrem, M.; Morales, A.; Williams, C.; Harrison, S. A.] Brooke Army Med Ctr, San Antonio, TX USA. EM michael.hjelkrem@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-8278 J9 J HEPATOL JI J. Hepatol. PD APR PY 2012 VL 56 SU 2 MA 1292 BP S510 EP S510 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 931TD UT WOS:000303241302399 ER PT J AU Oshman, C Li, Q Liew, LA Yang, RG Lee, YC Bright, VM Sharar, DJ Jankowski, NR Morgan, BC AF Oshman, Christopher Li, Qian Liew, Li-Anne Yang, Ronggui Lee, Y. C. Bright, Victor M. Sharar, Darin J. Jankowski, Nicholas R. Morgan, Brian C. TI Thermal performance of a flat polymer heat pipe heat spreader under high acceleration SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article AB This paper presents the fabrication and application of a micro-scale hybrid wicking structure in a flat polymer-based heat pipe heat spreader, which improves the heat transfer performance under high adverse acceleration. The hybrid wicking structure which enhances evaporation and condensation heat transfer under adverse acceleration consists of 100 mu m high, 200 mu m wide square electroplated copper micro-pillars with 31 mu m wide grooves for liquid flow and a woven copper mesh with 51 mu m diameter wires and 76 mu m spacing. The interior vapor chamber of the heat pipe heat spreader was 30x30x1.0 mm(3). The casing of the heat spreader is a 100 mu m thick liquid crystal polymer which contains a two-dimensional array of copper-filled vias to reduce the overall thermal resistance. The device performance was assessed under 0-10 g acceleration with 20, 30 and 40 W power input on an evaporator area of 8x8 mm(2). The effective thermal conductivity of the device was determined to range from 1653 W (m K)(-1) at 0 g to 541 W (m K)(-1) at 10 g using finite element analysis in conjunction with a copper reference sample. In all cases, the effective thermal conductivity remained higher than that of the copper reference sample. This work illustrates the possibility of fabricating flexible, polymer-based heat pipe heat spreaders compatible with standardized printed circuit board technologies that are capable of efficiently extracting heat at relatively high dynamic acceleration levels. C1 [Oshman, Christopher; Li, Qian; Liew, Li-Anne; Yang, Ronggui; Lee, Y. C.; Bright, Victor M.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. [Sharar, Darin J.] Gen Tech Serv LLC, Wall, NJ USA. [Jankowski, Nicholas R.; Morgan, Brian C.] USA, Res Lab, Adelphi, MD USA. RP Oshman, C (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA. EM victor.bright@colorado.edu RI Yang, Ronggui/H-1278-2011 FU DARPA [N66001-08-C-2006]; NNIN; National Science Foundation [ECS-0335765] FX This work was supported by the DARPA Thermal Ground Plane Program managed by Dr Thomas W Kenny and Dr Avram Bar-Cohen (N66001-08-C-2006). The microfabrication process described in this work was conducted in the Colorado Nanofabrication Laboratories, which is supported by the NNIN and the National Science Foundation under grant no ECS-0335765. The views expressed are those of the author and do not reflect the official policy or position of the Department of Defense or the US Government. The authors thank Nick Marsiglia and Susan Song for assistance in fabrication. NR 19 TC 18 Z9 18 U1 6 U2 23 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD APR PY 2012 VL 22 IS 4 AR 045018 DI 10.1088/0960-1317/22/4/045018 PG 12 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 931EB UT WOS:000303196900018 ER PT J AU Smith, TJ Crombie, A Sanders, LF Sigrist, LD Bathalon, GP McGraw, S Young, AJ AF Smith, Tracey J. Crombie, Aaron Sanders, LesLee Funderburk Sigrist, Lori D. Bathalon, Gaston P. McGraw, Susan Young, Andrew J. TI Efficacy of Orlistat 60 mg on Weight Loss and Body Fat Mass in US Army Soldiers SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Article DE Weight loss; Body fat loss; Military; Pharmacotherapy ID RISK-FACTORS; MEAL REPLACEMENTS; OBESITY; MAINTENANCE; OVERWEIGHT; INJURIES; ADULTS AB A higher body mass index is associated with exercise-related injuries and increased risk for musculoskeletal and connective tissue disorders, which are relevant to military personnel. Studies show the efficacy of orlistat 60 mg for promoting weight and body fat loss in civilians; however, its efficacy among predominantly young, male soldiers is unknown. This study's objective was to examine the effect of a 6-month, standard education-based weight-management program with and without orlistat 60 mg on changes in weight and body fat in overweight soldiers. Data were collected for this randomized, controlled trial from March 2008 to November 2010 at Fort Bragg, NC. Participants were enrolled in an education-based weight management program (n = 435; 75% men) and were randomized to placebo or orlistat 60 mg, three capsules daily with meals. All participants were recommended to maintain a reduced-energy, low-fat diet. Among study completers (14% retention rate; placebo n = 22, orlistat n = 35) members of both groups lost significant weight from baseline (placebo -3.0 +/- 5.2 kg; orlistat -3.2 +/- 4.7 kg; P<0.01), but only the orlistat group lost fat mass (-2.5 +/- 3.9 kg; P<0.001), whereas the placebo group lost lean mass (-1.4 +/- 2.7 kg; P <0.01). An intent-to-treat analysis (>= 1 follow-up body weight measure) demonstrated that the orlistat group lost more fat mass vs the placebo group (-1.3 +/- 2.9 kg vs -0.6 +/- 1.8 kg, respectively; P<0.05), but less lean mass (-0.2-1 +/- 2.0 kg vs -0.8 +/- 1.8 kg, respectively; P<0.01). Orlistat 60 mg may be an effective adjunct to an education-based weight management program in a mostly young, male soldier population. Acad Nutr Diet. 2012;112:533-540. C1 [Smith, Tracey J.; Crombie, Aaron; Sanders, LesLee Funderburk; Sigrist, Lori D.; Bathalon, Gaston P.; McGraw, Susan; Young, Andrew J.] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Sanders, LesLee Funderburk] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Sigrist, Lori D.] Grad Program Nutr, Ft Sam Houston, TX USA. RP Smith, TJ (reprint author), USA, Mil Nutr Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Tracey.j.smith@us.army.mil NR 24 TC 3 Z9 3 U1 0 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 2212-2672 J9 J ACAD NUTR DIET JI J. Acad. Nutr. Diet. PD APR PY 2012 VL 112 IS 4 BP 533 EP 540 DI 10.1016/j.jada.2011.10.006 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 930WR UT WOS:000303175900011 PM 22717217 ER PT J AU Taylor, S Matrajt, G Guan, YB AF Taylor, Susan Matrajt, Graciela Guan, Yunbin TI Fine-grained precursors dominate the micrometeorite flux SO METEORITICS & PLANETARY SCIENCE LA English DT Article ID STONY COSMIC SPHERULES; DEEP-SEA SPHERULES; ANTARCTIC MICROMETEORITES; ATMOSPHERIC ENTRY; CARBONACEOUS CHONDRITES; ELEMENTAL COMPOSITION; ISOTOPIC COMPOSITIONS; INTERPLANETARY DUST; COMETARY ORIGIN; ACCRETION RATE AB We optically classified 5682 micrometeorites (MMs) from the 2000 South Pole collection into textural classes, imaged 2458 of these MMs with a scanning electron microscope, and made 200 elemental and eight isotopic measurements on those with unusual textures or relict phases. As textures provide information on both degree of heating and composition of MMs, we developed textural sequences that illustrate how fine-grained, coarse-grained, and single mineral MMs change with increased heating. We used this information to determine the percentage of matrix dominated to mineral dominated precursor materials (precursors) that produced the MMs. We find that at least 75% of the MMs in the collection derived from fine-grained precursors with compositions similar to CI and CM meteorites and consistent with dynamical models that indicate 85% of the mass influx of small particles to Earth comes from Jupiter family comets. A lower limit for ordinary chondrites is estimated at 28% based on MMs that contain Na-bearing plagioclase relicts. Less than 1% of the MMs have achondritic compositions, CAI components, or recognizable chondrules. Single mineral MMs often have magnetite zones around their peripheries. We measured their isotopic compositions to determine if the magnetite zones demarcate the volume affected by atmospheric exchange during entry heating. Because we see little gradient in isotopic composition in the olivines, we conclude that the magnetites are a visual marker that allows us to select and analyze areas not affected by atmospheric exchange. Similar magnetite zones are seen in some olivine and pyroxene relict grains contained within MMs. C1 [Taylor, Susan] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Matrajt, Graciela] Univ Washington, Seattle, WA 98105 USA. [Guan, Yunbin] CALTECH, Pasadena, CA 91125 USA. RP Taylor, S (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM susan.taylor@usace.army.mil FU NSF FX The authors thank Dave Joswiak and Dr. Hope Ishii for reviewing this article and providing many helpful suggestions. Dr. Gregory Herzog is thanked for the many helpful discussions on this work. We thank NSF (Dr. Julie Palais, program manager) for funding the collection of micrometeorites from the SPWW and NASA (Dr. David Lindstrom, program manager) for funding the analysis of the 2000 collection. The authors also thank Sarah E. Wengert and other Women in Science Project students at Dartmouth College for imaging hundreds of these micrometeorites and Dr. Charles Daghlian for comentoring these students. NR 57 TC 18 Z9 18 U1 2 U2 10 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD APR PY 2012 VL 47 IS 4 BP 550 EP 564 DI 10.1111/j.1945-5100.2011.01292.x PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 931SW UT WOS:000303240600004 ER PT J AU Crimmins, M Etienne, M AF Crimmins, Michael Etienne, Mill TI Fit for Duty: Autonomic Nervous System Dysfunction in US Service Members SO NEUROLOGY LA English DT Meeting Abstract CT 64th Annual Meeting of the American-Academy-of-Neurology (AAN) CY APR 21-28, 2012 CL New Orleans, LA SP Amer Acad Neurol (AAN) C1 [Crimmins, Michael] Walter Reed Army Med Ctr, Bethesda, MD USA. [Etienne, Mill] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 2012 VL 78 SU 1 MA P05201 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 931GQ UT WOS:000303204802439 ER PT J AU Robinson, A Sherman, P Kochumov, P Grogan, P McGuire, S AF Robinson, Andrew Sherman, Paul Kochumov, Peter Grogan, Patrick McGuire, Stephen TI Prevalence of Neurologic Decompression Sickness and Necrotic Brain Lesions in High-Altitude Pilots SO NEUROLOGY LA English DT Meeting Abstract CT 64th Annual Meeting of the American-Academy-of-Neurology (AAN) CY APR 21-28, 2012 CL New Orleans, LA SP Amer Acad Neurol (AAN) C1 [Robinson, Andrew] Brooke Army Med Ctr, Dept Neurol, San Antonio, TX USA. [Sherman, Paul] 59th Med Wing, Dept Neuroradiol, Lackland AFB, TX USA. [Kochumov, Peter] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA. [Grogan, Patrick] 59th Med Wing, Dept Neurol, San Antonio, TX USA. [McGuire, Stephen] USAFSAM FECN, Dept Neurol, Lackland AFB, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 2012 VL 78 SU 1 MA S08005 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 931GQ UT WOS:000303204800417 ER PT J AU Royal, W Lee-Wilk, T Wallin, M Bever, C Kane, R Maloni, H Finkelstein, J Cha, E McCarthy, M Levin, M Tyor, W Culpepper, J Mitchell, L Zhan, M AF Royal, Walter Lee-Wilk, Terry Wallin, Mitchell Bever, Christopher Kane, Robert Maloni, Heidi Finkelstein, Joseph Cha, Eunme McCarthy, Micheline Levin, Michael Tyor, William Culpepper, Joel Mitchell, Lisa Zhan, Min TI CXCR3+Naive T Helper Cell Percentages Correlate with Neuropsychological Test Abnormalities in Patients with MS SO NEUROLOGY LA English DT Meeting Abstract CT 64th Annual Meeting of the American-Academy-of-Neurology (AAN) CY APR 21-28, 2012 CL New Orleans, LA SP Amer Acad Neurol (AAN) C1 [Royal, Walter; Zhan, Min] Univ Maryland, Baltimore, MD 21201 USA. [Lee-Wilk, Terry; Culpepper, Joel; Mitchell, Lisa] Baltimore VA Med Ctr, Baltimore, MD USA. [Wallin, Mitchell] Washington DC VA Med Ctr, Arlington, VA USA. [Bever, Christopher] Baltimore Vet Adm Med Ctr, Baltimore, MD USA. [Kane, Robert] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Maloni, Heidi] Washington DC VAMC, Washington, DC USA. [Finkelstein, Joseph; Cha, Eunme] Johns Hopkins Univ, Baltimore, MD USA. [McCarthy, Micheline] Miami VA Med Ctr, Miami, FL USA. [Levin, Michael] Memphis VA Med Ctr, Memphis, TN USA. [Tyor, William] Atlanta VA Med Ctr, Decatur, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 2012 VL 78 SU 1 MA P04102 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 931GQ UT WOS:000303204802348 ER PT J AU Wilk, JE Herrell, RK Wynn, GH Riviere, LA Hoge, CW AF Wilk, Joshua E. Herrell, Richard K. Wynn, Gary H. Riviere, Lyndon A. Hoge, Charles W. TI Mild Traumatic Brain Injury (Concussion), Posttraumatic Stress Disorder, and Depression in US Soldiers Involved in Combat Deployments: Association With Postdeployment Symptoms SO PSYCHOSOMATIC MEDICINE LA English DT Article DE concussion; PTSD; depression; combat; deployment ID PERSISTENT POSTCONCUSSIVE SYMPTOMS; MENTAL-HEALTH PROBLEMS; HEAD-INJURY; COGNITIVE PERFORMANCE; DIAGNOSIS THREAT; SOMATIC SYMPTOMS; WAR VETERANS; IRAQ; CARE; AFGHANISTAN AB Objectives: Several studies have examined the relationship between concussion/mild traumatic brain injury (mTBI), posttraumatic stress disorder (PTSD), depression, and postdeployment symptoms. These studies indicate that the multiple factors involved in postdeployment symptoms are not accounted for in the screening processes of the Department of Defense/Veteran's Affairs months after concussion injuries. This study examined the associations of single and multiple deployment-related mTBIs on postdeployment health. Methods: A total of 1502 U.S. Army soldiers were administered anonymous surveys 4 to 6 months after returning from deployment to Iraq or Afghanistan assessing history of deployment-related concussions, current PTSD, depression, and presence of postdeployment physical and neurocognitive symptoms. Results: Of these soldiers, 17% reported an mTBI during their previous deployment. Of these, 59% reported having more than one. After adjustment for PTSD, depression, and other factors, loss of consciousness was significantly associated with three postconcussive symptoms, including headaches (odds ratio [OR] = 1.5, 95% confidence interval [Cl] = 1.1-2.3). However, these symptoms were more strongly associated with PTSD and depression than with a history of mTBI. Multiple mTBIs with loss of consciousness increased the risk of headache (OR = 4.0, 95% CI = 2.4-6.8) compared with a single occurrence, although depression (OR = 4.2, 95% Cl = 2.6-6.8) remained as strong a predictor. Conclusions: These data indicate that current screening tools for mTBI being used by the Department of Defense/Veteran's Affairs do not optimally distinguish persistent postdeployment symptoms attributed to mTBI from other causes such as PTSD and depression. Accumulating evidence strongly supports the need for multidisciplinary collaborative care models of treatment in primary care to collectively address the full spectrum of postwar physical and neurocognitive health concerns. C1 [Wilk, Joshua E.] USA, Dept Mil Psychiat, Div Psychiat & Neurosci, Walter Reed Army Inst Res,Med Res & Mat Command, Silver Spring, MD 20910 USA. RP Wilk, JE (reprint author), USA, Dept Mil Psychiat, Div Psychiat & Neurosci, Walter Reed Army Inst Res,Med Res & Mat Command, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joshua.wilk@amedd.army.mil NR 51 TC 56 Z9 56 U1 4 U2 22 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0033-3174 J9 PSYCHOSOM MED JI Psychosom. Med. PD APR PY 2012 VL 74 IS 3 BP 249 EP 257 DI 10.1097/PSY.0b013e318244c604 PG 9 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 930JS UT WOS:000303136300003 PM 22366583 ER PT J AU Kotti, GH Bell, DG Matthews, T Lucero, PF Morris, MJ AF Kotti, George H. Bell, David G. Matthews, Tokunbo Lucero, Pedro F. Morris, Michael J. TI Correlation of Airway Hyper-responsiveness With Obstructive Spirometric Indices and FEV1 > 90% of Predicted SO RESPIRATORY CARE LA English DT Article DE pulmonary function testing; normal FEV1; obstruction; airway hyper-responsiveness ID INCREASED ALVEOLAR NUMBER; PULMONARY-FUNCTION; LARGE LUNGS; SWIMMERS AB BACKGROUND: Current published guidelines on spirometry interpretation suggest an elevated FVC and FEV1 > 100% of predicted with an obstructive ratio may represent a physiological variant. There is minimal evidence whether this finding can be indicative of symptomatic air ways obstruction. METHODS: Pulmonary function testing databases for a 4-year period were retrospectively reviewed. All technically adequate spirometry studies were included, based on these criteria: FEV1 > 90% of predicted, and FEV1/FVC below the lower limit of normal, based on 95th percentile confidence intervals. Clinical indications for testing were noted. Testing for post-bronchodilator response, lung volumes, and methacholine challenge tests were reviewed for evidence of airway hyper-responsiveness (AHR). Comparisons were made between symptomatic versus asymptomatic individuals and FEV1 values less than or greater than 100% of predicted. RESULTS: A total of 280 studies were analyzed. During their clinical evaluation, 192 patients (69%) had post-bronchodilator spirometry recorded, 63 patients (23%) had lung volumes,, and 36 patients (11%) completed methacholine challenge testing. Indications for spirometry included 193 symptomatic patients and 87 asymptomatic patients. Nearly 28% of patients with post-bronchodilator testing met criteria for AHR. No differences in AHR were found between the symptomatic and asymptomatic groups. The majority of patients (77%) with AHR had an FEV1 < 100%, when compared to patients with an FEV1 >= 100%. CONCLUSIONS: A normal FEV1 > 90% of predicted with obstructive indices may not represent a normal physiological variant, as 28% of patients were found to have underlying AHR. These findings suggest that clinicians should evaluate for AHR, especially in symptomatic patients, even if the FEV1 is > 90% of predicted. C1 [Kotti, George H.] Keesler AF Base, Pulm Dis Serv, Keesler Med Ctr, Biloxi, MS USA. [Bell, David G.; Matthews, Tokunbo; Lucero, Pedro F.; Morris, Michael J.] Brooke Army Med Ctr, Wilford Hall Med Ctr, Dept Med, Pulm Dis Crit Care Serv, San Antonio, TX USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michael.morris@amedd.army.mil NR 20 TC 2 Z9 2 U1 1 U2 1 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD APR PY 2012 VL 57 IS 4 BP 565 EP 571 DI 10.4187/respcare.01244 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 927RT UT WOS:000302928500009 PM 22004588 ER PT J AU Bale, S Dias, JM Fusco, ML Hashiguchi, T Wong, AC Liu, T Keuhne, AI Li, S Woods, VL Chandran, K Dye, JM Saphire, EO AF Bale, Shridhar Dias, Joao M. Fusco, Marnie L. Hashiguchi, Takao Wong, Anthony C. Liu, Tong Keuhne, Ana I. Li, Sheng Woods, Virgil L., Jr. Chandran, Kartik Dye, John M. Saphire, Erica Ollmann TI Structural Basis for Differential Neutralization of Ebolaviruses SO VIRUSES-BASEL LA English DT Article DE Filovirus; Ebola; ebolavirus; Sudan virus; neutralization: glycoprotein; antibodies; structure ID EBOLA-VIRUS GLYCOPROTEIN; MEMBRANE-FUSION; PASSIVE TRANSFER; ANTIBODY; ENTRY; CATHEPSINS; INFECTION; SOFTWARE; SEQUENCE; SUBUNIT AB There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Tai Forest virus, and Bundibugyo virus). The small handful of antibodies known to neutralize the ebolaviruses bind to the surface glycoprotein termed GP(1,2). Curiously, some antibodies against them are known to neutralize in vitro but not protect in vivo, whereas other antibodies are known to protect animal models in vivo, but not neutralize in vitro. A detailed understanding of what constitutes a neutralizing and/or protective antibody response is critical for development of novel therapeutic strategies. Here, we show that paradoxically, a lower affinity antibody with restricted access to its epitope confers better neutralization than a higher affinity antibody against a similar epitope, suggesting that either subtle differences in epitope, or different characteristics of the GP(1,2) molecules themselves, confer differential neutralization susceptibility. Here, we also report the crystal structure of trimeric, prefusion GP(1,2) from the original 1976 Boniface variant of Sudan virus complexed with 16F6, the first antibody known to neutralize Sudan virus, and compare the structure to that of Sudan virus, variant Gulu. We discuss new structural details of the GP(1)-GP(2) clamp, thermal motion of various regions in GP(1,2) across the two viruses visualized, details of differential interaction of the crystallized neutralizing antibodies, and their relevance for virus neutralization. C1 [Bale, Shridhar; Dias, Joao M.; Fusco, Marnie L.; Hashiguchi, Takao; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Wong, Anthony C.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA. [Liu, Tong; Li, Sheng; Woods, Virgil L., Jr.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. [Keuhne, Ana I.; Dye, John M.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. RP Saphire, EO (reprint author), Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. EM sbale@scripps.edu; jmcndias@yahoo.com; mhavert@scripps.edu; takaoh@scripps.edu; anthony.wong@med.einstein.yu.edu; toliu@ucsd.edu; ana.kuehne@us.army.mil; s4li@ucsd.edu; vwoods@ucsd.edu; kartik.chandran@einstein.yu.edu; john.m.dye1@us.army.mil; erica@scripps.edu FU NIH [AI081982, AI072106, AI068730, AI2008031, GM020501, GM066170, NS070899, GM093325, RR029388, AI088027, AI082437, AI067927, AI070530]; Skaggs Institute for Chemical Biology; Burroughs Wellcome Fund; DTRA [CBM.THRV.01.RD.11.001] FX We thank Dennis Burton's lab at TSRI for use of the BIAcore spectrophotometer and assistance with experiments. We thank Dafna Abelson and Michelle Zandonatti for technical assistance, and Christina Corbaci for preparation of Figure 8. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U. S. Army. The work is supported by NIH grants AI081982, AI072106, AI068730, AI2008031, GM020501, GM066170, NS070899, GM093325, and RR029388 (V.L.W.); AI088027, AI082437 (K.C.); AI067927, AI081982, AI070530, The Skaggs Institute for Chemical Biology, and an Investigators in the Pathogenesis of Infectious Disease Award from the Burroughs Wellcome Fund (E. O .S.). J. M. D. kindly thanks DTRA project CBM.THRV.01.RD.11.001 for their generous support. This is manuscript #21503 from The Scripps Research Institute. NR 32 TC 28 Z9 30 U1 2 U2 12 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1999-4915 J9 VIRUSES-BASEL JI Viruses-Basel PD APR PY 2012 VL 4 IS 4 BP 447 EP 470 DI 10.3390/v4040447 PG 24 WC Virology SC Virology GA 932AL UT WOS:000303261200002 PM 22590681 ER PT J AU Shakarian, P Simari, GI Subrahmanian, VS AF Shakarian, Paulo Simari, Gerardo I. Subrahmanian, V. S. TI Annotated Probabilistic Temporal Logic: Approximate Fixpoint Implementation SO ACM TRANSACTIONS ON COMPUTATIONAL LOGIC LA English DT Article DE Algorithms; Languages; Probabilistic and temporal reasoning; threads; frequency functions; imprecise probabilities ID CALCULUS AB Annotated Probabilistic Temporal (APT) logic programs support building applications where we wish to reason about statements of the form "Formula G becomes true with a probability in the range [L, U] within (or in exactly) Delta t time units after formula F became true." In this paper, we present a sound, but incomplete fixpoint operator that can be used to check consistency and entailment in APT logic programs. We present the first implementation of APT-logic programs and evaluate both its compute time and convergence on a suite of 23 ground APT-logic programs that were automatically learned from two real-world data sets. In both cases, the APT-logic programs contained up to 1,000 ground rules. In one data set, entailment problems were solved on average in under 0.1 seconds per ground rule, while in the other, it took up to 1.3 seconds per ground rule. Consistency was also checked in a reasonable amount of time. When discussing entailment of APT-logic formulas, convergence of the fixpoint operator refers to (U-L) being below a certain threshold. We show that on virtually all of the 23 automatically generated APT-logic programs, convergence was quick-often in just 2-3 iterations of the fixpoint operator. Thus, our implementation is a practical first step towards checking consistency and entailment in temporal probabilistic logics without independence or Markovian assumptions. C1 [Shakarian, Paulo; Simari, Gerardo I.; Subrahmanian, V. S.] Univ Maryland, College Pk, MD 20742 USA. RP Shakarian, P (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, Thayer Hall,Bldg 601, West Point, NY 10996 USA. EM paulo@shakarian.net; gerardo.simari@cs.ox.ac.uk; vs@umiacs.umd.edu OI Simari, Gerardo/0000-0003-3185-4992 FU US Army ACS/West Point Instructor (EECS); AFOSR [FA95500610405]; ARO [W911NF0910206]; ONR [N000140910685] FX P. Shakarian is funded under the US Army ACS/West Point Instructor (EECS) program.; Some of the authors of this article were funded in part by AFOSR grant FA95500610405, ARO grant W911NF0910206, and ONR grant N000140910685. NR 29 TC 4 Z9 4 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 1529-3785 J9 ACM T COMPUT LOG JI ACM Trans. Comput. Log. PD APR PY 2012 VL 13 IS 2 AR 13 DI 10.1145/2159531.2159535 PG 33 WC Computer Science, Theory & Methods; Logic SC Computer Science; Science & Technology - Other Topics GA 929FX UT WOS:000303047800004 ER PT J AU Lapchak, PH Kannan, L Ioannou, A Rani, P Karian, P Lucca, JJD Tsokos, GC AF Lapchak, Peter H. Kannan, Lakshmi Ioannou, Antonis Rani, Poonam Karian, Peter Lucca, Jurandir J. Dalle Tsokos, George C. TI Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE ischemia-reperfusion injury; intestine; lung; complement; platelet depletion ID INFLAMMATORY-BOWEL-DISEASE; VASCULAR ENDOTHELIAL-CELLS; ANTIGEN-INDUCED ARTHRITIS; P-SELECTIN; COMPLEMENT ACTIVATION; ISCHEMIA/REPERFUSION INJURY; LEUKOCYTE INTERACTIONS; COATED-PLATELETS; ORGAN DAMAGE; T-CELL AB Platelets orchestrate remote tissue damage after mesenteric ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol 302: G888-G897, 2012. First published February 2, 2012; doi:10.1152/ajpgi.00499.2011.-Ischemia-reperfusion (I/R) injury is a leading cause of morbidity and mortality. A functional role for platelets in tissue damage after mesenteric I/R is largely unknown. The hypothesis that mesenteric I/R local and remote injury are platelet dependent was tested. Using a murine mesenteric I/R model, we demonstrate that platelets orchestrate remote lung tissue damage that follows mesenteric I/R injury and also contribute, albeit to a lesser degree, to local villi damage. While lung damage is delayed compared with villi damage, it increased over time and was characterized by accumulation of platelets in the pulmonary vasculature early, followed by alveolar capillaries and extravasation into the pulmonary space. Both villi and lung tissues displayed complement deposition. We demonstrate that villi and lung damage are reduced in mice made platelet deficient before I/R injury and that platelet transfusion into previously platelet-depleted mice before I/R increased both villi and lung tissue damage. Increased C3 deposition accompanied platelet sequestration in the lung, which was mostly absent in platelet-depleted mice. In contrast, C3 deposition was only minimally reduced on villi of platelet-depleted mice. Our findings position platelets alongside complement as a significant early upstream component that orchestrates remote lung tissue damage after mesenteric I/R and strongly suggest that reperfusion injury mitigating modalities should consider the contribution of platelets. C1 [Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol,Dept Med, Boston, MA 02115 USA. [Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA. RP Tsokos, GC (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol,Dept Med, 330 Brookline Ave,CLS-928, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu RI Ji, Haofeng/G-6206-2012; OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530, W81XWH-09-1-10536] FX The research presented herein was supported by Grant nos. W81XWH-09-1-0530 and W81XWH-09-1-10536 from Medical Research and Material Command of the Department of the Army. NR 86 TC 12 Z9 12 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD APR PY 2012 VL 302 IS 8 BP G888 EP G897 DI 10.1152/ajpgi.00499.2011 PG 10 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA 927OT UT WOS:000302918300013 PM 22301111 ER PT J AU Mc Gann, P Hang, J Clifford, RJ Yang, Y Kwak, YI Kuschner, RA Lesho, EP Waterman, PE AF Mc Gann, Patrick Hang, Jun Clifford, Robert J. Yang, Yu Kwak, Yoon I. Kuschner, Robert A. Lesho, Emil P. Waterman, Paige E. TI Complete Sequence of a Novel 178-Kilobase Plasmid Carrying bla(NDM-1) in a Providencia stuartii Strain Isolated in Afghanistan SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID METALLO-BETA-LACTAMASE; MULTIDRUG-RESISTANCE; NDM-1; BACTERIA; SURVEILLANCE; GENOMICS; HEALTH AB In response to global concerns over the spread of the New Delhi metallo-beta-lactamase gene 1, bla(NDM-1), a monthly surveillance program was initiated in September 2010. All carbapenem-resistant Gram-negative strains forwarded to our facility are screened for this gene. To date, 321 carbapenem-resistant isolates, encompassing 11 bacterial species, have been tested. In February 2011, two strains of Providencia stuartii, submitted from a military hospital in Afghanistan, tested positive for bla(NDM-1). Both strains were identical by pulsed-field gel electrophoresis (PFGE). bla(NDM-1) was carried on a large plasmid, pMR0211, which was sequenced by emulsion PCR and pyrosequencing. pMR0211 is 178,277 bp in size and belongs to incompatibility group A/C. The plasmid consists of a backbone with considerable homology to pAR060302 from Escherichia coli, and it retains many of the antibiotic resistance genes associated with it. The plasmid also shares common elements with the pNDM-HK plasmid, including bla(NDM-1), armA, and sull. However, gene orientation is reversed, and a 3-kb fragment from this region is absent from pMR0211. pMR0211 also contains additional genes, including the aminoglycoside-modifying enzyme loci aadA and aac(6'), the quinolone resistance gene qnrA, a gene with highest homology to a U32 family peptidase from Shewanella amazonensis, and the bla(OXA-10) gene. The finding of this gene in an intrinsically colistin-resistant species such as Providencia stuartii is especially worrisome, as it renders the organism resistant to nearly every available antibiotic. The presence of multiple insertion sequences and transposons flanking the region containing the bla(NDM-1) gene further highlights the potential mobility associated with this gene. C1 [Mc Gann, Patrick; Clifford, Robert J.; Kwak, Yoon I.; Lesho, Emil P.; Waterman, Paige E.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Hang, Jun; Yang, Yu; Kuschner, Robert A.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA. RP Mc Gann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. EM patrick.t.mcgann.ctr@us.army.mil NR 26 TC 47 Z9 50 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD APR PY 2012 VL 56 IS 4 BP 1673 EP 1679 DI 10.1128/AAC.05604-11 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 913SU UT WOS:000301898500001 PM 22290972 ER PT J AU Renz, EM Ling, G Mork, KJ Ecklund, JM AF Renz, Evan M. Ling, Geoffrey Mork, Kevin J. Ecklund, James M. TI Image of the Month Send Serum for Coagulation Studies and Obtain Computed Tomographic Imaging of the Brain SO ARCHIVES OF SURGERY LA English DT Editorial Material ID INJURIES C1 [Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Renz, Evan M.; Ecklund, James M.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Ling, Geoffrey] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Mork, Kevin J.] Altru Hlth Syst, Fargo, ND USA. [Ecklund, James M.] Inova Fairfax Hosp, Falls Church, VA USA. [Ecklund, James M.] Virginia Commonwealth Univ, Dept Neurosurg, Richmond, VA 23284 USA. RP Renz, EM (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Dr, Ft Sam Houston, TX 78234 USA. EM evan.renz@us.army.mil NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD APR PY 2012 VL 147 IS 4 BP 391 EP 392 PG 2 WC Surgery SC Surgery GA 927JX UT WOS:000302904600023 PM 22508789 ER PT J AU Krnavek, L Simpson, WR Carlson, D Domine, F Douglas, TA Sturm, M AF Krnavek, Laura Simpson, William R. Carlson, Daniel Domine, Florent Douglas, Thomas A. Sturm, Matthew TI The chemical composition of surface snow in the Arctic: Examining marine, terrestrial, and atmospheric influences SO ATMOSPHERIC ENVIRONMENT LA English DT Article DE Snow; Chemical composition; Ionic composition; Fractionation; Sea salt; Air-snow flux ID SEA-SALT AEROSOL; OZONE DEPLETION EVENTS; BOUNDARY-LAYER; POLAR SUNRISE; TROPOSPHERIC CHEMISTRY; FROST FLOWERS; ICE; BROMINE; MERCURY; COASTAL AB We collected surface snow samples during three years (2004, 2005, and 2007) in Arctic Alaska and from the adjoining frozen Arctic Ocean during springtime in environments that span most Arctic terrains including land, thin and thick first-year sea ice, and multi-year sea ice. The snow was analyzed for Br-, Cl-, SO42-, NO3-, NH4+, Na+, K+, Mg2+ and Ca2+. Source fractionation processes and atmospheric influences are important modification mechanisms that influence the ions. We find that Cl-, K+ and Mg2+ are primarily sourced by unfractionated sea salt and only show deviations from sea salt composition at low Na+ concentrations. Bromide and Ca2+ are highly influenced by atmospheric processes that are evident at low sea salt tracer concentrations. Calcium enrichments are due to the addition of non-sea salt (nss)Ca2+ from dust and possibly other sources. Bromide enrichments are due to the addition of nss-Br- and bromide depletions are due to bromine activation to the gas phase. Sulfate is affected by source fractionation at high Na+ concentrations and by atmospheric addition at low Na+ concentrations. Nitrate and NH4+ are not correlated with sea salt and show less concentration variability than sea salt ions. Modifications are related to time-integrated air-snow exchange fluxes for Br-, SO42- and Ca2+ and are in good agreement with observations of related gas-phase and aerosol species. This work reinforces our understanding of air-snow exchanges and their importance for atmospheric chemistry in the Arctic. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Krnavek, Laura; Simpson, William R.; Carlson, Daniel] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Krnavek, Laura; Simpson, William R.; Carlson, Daniel] Univ Alaska Fairbanks, Dept Geophys Inst, Fairbanks, AK 99775 USA. [Domine, Florent] Univ Laval, TAKUVIK Joint Int Lab, Quebec City, PQ G1V 0A6, Canada. [Domine, Florent] Ctr Natl Rech Sci, F-75794 Paris 16, France. [Douglas, Thomas A.; Sturm, Matthew] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Simpson, WR (reprint author), Univ Alaska Fairbanks, Dept Chem & Biochem, 900 Yukon Dr,Room 186, Fairbanks, AK 99775 USA. EM Laura.Krnavek@erg.com; wrsimpson@alaska.edu RI Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 FU National Science Foundation [OPP-0435989]; US Department of Energy; Cooperative Institute for Arctic Research (CIFAR) [OPP-0435922, ARC-0612457] FX This work was funded by the National Science Foundation Office of Polar Programs Arctic Sciences Section: Sturm and Douglas (OPP-0435989) and Krnavek, Simpson, and Carlson (OPP-0435922 and ARC-0612457). Krnavek was supported by a US Department of Energy Global Change Education Program (GCEP) Graduate Research Educational Fellowship (GREF). Carlson was partially supported by a grant from the Cooperative Institute for Arctic Research (CIFAR). The Barrow Arctic Science Consortium (BASC) provided logistical support, and their assistance is greatly appreciated. We thank the University of Washington Applied Physics Laboratory Ice Station (APLIS) ice camp organizers for logistical support. NR 59 TC 18 Z9 18 U1 21 U2 75 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1352-2310 EI 1873-2844 J9 ATMOS ENVIRON JI Atmos. Environ. PD APR PY 2012 VL 50 BP 349 EP 359 DI 10.1016/j.atmosenv.2011.11.033 PG 11 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 909JP UT WOS:000301561100038 ER PT J AU Alfredsson, KS Gawandi, AA Gillespie, JW Carlsson, LA Bogetti, TA AF Alfredsson, K. S. Gawandi, A. A. Gillespie, J. W., Jr. Carlsson, L. A. Bogetti, T. A. TI Flexural analysis of discontinuous tile core sandwich structure SO COMPOSITE STRUCTURES LA English DT Article DE Sandwich; FEA; Compliance; Interlaminar; Stress ID VARIATIONAL APPROACH; ARMOR AB Three-point flexure loading of sandwich beams with a core consisting of discrete ceramic tiles (DTSS) is considered. The tile gaps may be bonded or unbonded (open gaps). The analysis utilizes a layer-wise beam theory approach. The general formulation for the displacements and stresses in the face sheets, face/core adhesive layer, and core is derived. Solutions for stresses and displacements of the beam constituents are obtained from finite element formulation based on analytical solution of the face sheet/tile unit cell. The approach is verified by comparison to stress results obtained from ordinary finite element analysis where each layer is modeled discretely. Effects of load introduction and support conditions on the effective flexural stiffness are examined. It is demonstrated that the face sheets experience substantial stress concentrations at the tile joint locations, especially if the gaps are unfilled. Analysis of beam compliance reveals sensitivity to details of load introduction and support conditions, especially when the span length becomes comparable to the tile length. (C) 2011 Published by Elsevier Ltd. C1 [Gawandi, A. A.; Gillespie, J. W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Alfredsson, K. S.] Univ Skovde, S-54128 Skovde, Sweden. [Carlsson, L. A.] Florida Atlantic Univ, Dept Mech Engn, Boca Raton, FL 33431 USA. [Bogetti, T. A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM Gawandi@udel.edu; gillespi@udel.edu FU Army Research Laboratory FX The authors would like to acknowledge funding from Army Research Laboratory in support of this work. We are also grateful to Penny O'Donnell and Dawn Fiore at the Center for Composite Materials for the assistance with the preparation of this manuscript. NR 17 TC 4 Z9 4 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD APR PY 2012 VL 94 IS 5 BP 1524 EP 1532 DI 10.1016/j.compstruct.2011.11.028 PG 9 WC Materials Science, Composites SC Materials Science GA 928KA UT WOS:000302980400005 ER PT J AU Pankow, M Waas, AM Yen, CF Ghiorse, S AF Pankow, M. Waas, A. M. Yen, C. F. Ghiorse, S. TI Modeling the response, strength and degradation of 3D woven composites subjected to high rate loading SO COMPOSITE STRUCTURES LA English DT Article DE Hopkinson bar; High strain rate; 3D woven; RUC modeling; Material characterization ID BRAIDED TEXTILE COMPOSITES; FINITE-ELEMENT MODEL; FAILURE; IMPACT; FABRICATION; SIMULATION; BEHAVIOR; STRAIN AB Experimental results which were obtained using a split Hopkinson pressure bar (SHPB) apparatus to determine rate dependent effects, and reported by the authors in [1] are used as the basis to perform dynamic simulations of 3D woven composites (3DWCs) using representative unit cells (RUCs). The input material properties for the RUC simulations were determined from the concentric cylinder model (CCM) in conjunction with the geometry of the textile architecture, mechanical properties of pure epoxy samples and fiber mechanical properties. The RUC model incorporates rate dependent plasticity. Additionally, linear-eigen perturbations that correspond to buckling modes are used to seed imperfections in the RUC model to capture buckling and subsequent failure that was observed in experiments. The RUC model results showed good agreement with experiment and correctly captured the observed modes of failure while pointing to transitions in failure modes. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Pankow, M.; Waas, A. M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA. [Yen, C. F.; Ghiorse, S.] USA, Res Lab, Aberdeen, MD USA. RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA. EM dcw@umich.edu FU Army Research Laboratory, Aberdeen Proving Ground, MD FX The authors thank the Army Research Laboratory, Aberdeen Proving Ground, MD, for their continued financial support. NR 35 TC 14 Z9 14 U1 2 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD APR PY 2012 VL 94 IS 5 BP 1590 EP 1604 DI 10.1016/j.compstruct.2011.12.010 PG 15 WC Materials Science, Composites SC Materials Science GA 928KA UT WOS:000302980400012 ER PT J AU Hause, T AF Hause, Terry TI Elastic structural response of anisotropic sandwich plates with a first-order compressible core impacted by a Friedlander-type shock loading SO COMPOSITE STRUCTURES LA English DT Article DE Sandwich panel; Anisotropic face sheets; Dynamic response; Explosive blast; Transient response; Shock loading ID NONLINEAR DYNAMIC-RESPONSE; IN-AIR EXPLOSIONS; FLAT PANELS; BLAST; UNDERWATER AB The foundation of the non-linear theory of asymmetric anisotropic sandwich plates with a first order compressible weak orthotropic core under a Friedlander-type explosive blast is presented. The equations of motion are developed by means of Hamilton's Principle. Within the theory, the face sheets are asymmetric while adopting the Love-Kirchoff model. In addition, the core layer is assumed to be compressible (extensible) in the transverse direction thereby capturing any wrinkling or global instabilities. The theory is then simplified and applied for the case of sandwich plates with symmetric unidirectional fiber reinforced laminated composite facings with the axes of orthotropy not necessarily coincident with the geometrical axes. The governing solution is developed using the Extended-Galerkin method resulting in two coupled non-linear second order ordinary differential equations which are then solved using the 4th-order Runge-Kutta method for a system of differential equations. Published by Elsevier Ltd. C1 USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Hause, T (reprint author), USA, RDECOM TARDEC, Warren, MI 48397 USA. EM terry.hause@us.army.mil FU US Army-RDE-COM-TARDEC FX The author would like to express thanks to the US Army-RDE-COM-TARDEC for their support and funding under the Independent Laboratory In-house Research program (ILIR). NR 17 TC 3 Z9 3 U1 3 U2 23 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD APR PY 2012 VL 94 IS 5 BP 1634 EP 1645 DI 10.1016/j.compstruct.2011.12.020 PG 12 WC Materials Science, Composites SC Materials Science GA 928KA UT WOS:000302980400016 ER PT J AU Nilakantan, G Wetzel, ED Bogetti, TA Gillespie, JW AF Nilakantan, Gaurav Wetzel, Eric D. Bogetti, Travis A. Gillespie, John W., Jr. TI Finite element analysis of projectile size and shape effects on the probabilistic penetration response of high strength fabrics SO COMPOSITE STRUCTURES LA English DT Article DE Aramid fiber; Fabrics/textiles; Impact behavior; Finite element analysis (FEA); Probabilistic methods ID BALLISTIC IMPACT; PERFORATION; FRICTION; GEOMETRY AB The effects of projectile characteristics on the probabilistic impact response of single-layer fully-clamped flexible woven fabrics is numerically studied using a yarn-level fabric model with a statistical implementation of yarn strengths. Six small and large sized spherical, cylindrical, and conical projectiles of the same mass are considered. Probabilistic velocity response curves which describe the probability of fabric penetration as a function of projectile impact velocity are generated for each projectile type through a series of forty impact simulations at varying impact velocities. The probabilistic fabric impact response is observed to be strongly dependent on the shape of the projectile's impact face and the manner of projectile-yarn interactions at the impact site. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Nilakantan, Gaurav; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Wetzel, Eric D.; Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gauravnilakantan@yahoo.com; gillespi@udel.edu RI Nilakantan, Gaurav/B-8643-2012 OI Nilakantan, Gaurav/0000-0002-5375-9681 FU Army Research Laboratory [W911NF-06-2-0011] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement No. W911NF-06-2-0011. The views and conclusions contained in this document are those of the authors and should not be interested as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 22 TC 11 Z9 11 U1 1 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD APR PY 2012 VL 94 IS 5 BP 1846 EP 1854 DI 10.1016/j.compstruct.2011.12.028 PG 9 WC Materials Science, Composites SC Materials Science GA 928KA UT WOS:000302980400035 ER PT J AU Das, NC AF Das, Naresh C. TI Enhanced Performance of LWIR LED Devices by Backside Thinning and Isolating the Pixels SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE Infrared light-emitting diode (LED) device; LED efficiency; quantum cascade device; substrate thinning ID LIGHT-EMITTING-DIODES AB We observed a threefold increase in light emission power for long-wave infrared (LWIR) light-emitting diode (LED) devices by backside thinning and isolating the individual pixel from others. The proposed technique of backside thinning and isolating bottom emitting LED devices resulted in high yield of devices in an array. The voltage drop of the etched device is lower compared with the unetched device. This newly developed technique of device isolation opens the path to further device performance improvement by using grating and lenslet deposition on an individual LED pixel. C1 USA, Microphoton Branch, Res Lab, Adelphi, MD 20783 USA. RP Das, NC (reprint author), USA, Microphoton Branch, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Naresh.c.das2.civ@mail.mil NR 14 TC 3 Z9 3 U1 1 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD APR PY 2012 VL 59 IS 4 BP 1209 EP 1211 DI 10.1109/TED.2012.2185700 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 916FF UT WOS:000302083800046 ER PT J AU Darwish, AM Hung, HA Ibrahim, AA AF Darwish, Ali M. Hung, H. Alfred Ibrahim, Amr A. TI AlGaN/GaN HEMT With Distributed Gate for Channel Temperature Reduction SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article DE Channel temperature; GaN high electron-mobility transistor (HEMT); reliability; thermal resistance ID THERMAL-RESISTANCE AB Self heating in electronic devices reduces their performance and lifetime. A novel high electron-mobility transistor (HEMT) layout that reduces the channel temperature is presented. To decrease self heating, the new distributed gate (DG) HEMT is configured with multiple, active, and nonactive sections along each gate-stripe. Simulations and experimental results indicating the improved performance of the new layout are presented. Compared to a conventional HEMT, the fabricated novel DG GaN HEMT demonstrated a decrease in channel temperature from 178 degrees C to 150 degrees C, accompanied by a 3-dB increase in output power, and 13-fold increase in lifetime. C1 [Darwish, Ali M.; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA. [Ibrahim, Amr A.] AUC, Dept Elect Engn, Cairo 11835, Egypt. RP Darwish, AM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM darwish@alum.mit.edu; hahung@alum.mit.edu; amralaa87@gmail.com NR 16 TC 2 Z9 2 U1 1 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9480 EI 1557-9670 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD APR PY 2012 VL 60 IS 4 BP 1038 EP 1043 DI 10.1109/TMTT.2012.2185948 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA 921UZ UT WOS:000302504800014 ER PT J AU Gonzalez, RR Cheuvront, SN Ely, BR Moran, DS Hadid, A Endrusick, TL Sawka, MN AF Gonzalez, Richard R. Cheuvront, Samuel N. Ely, Brett R. Moran, Daniel S. Hadid, Amir Endrusick, Thomas L. Sawka, Michael N. TI Sweat rate prediction equations for outdoor exercise with transient solar radiation SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE thermoregulation; modeling; load carriage; environmental indexes; fluid replacement ID FLUID REPLACEMENT; HOT WEATHER; WATER NEEDS; HEAT; MODEL; ENVIRONMENT; VALIDATION; SIMULATION; RESPONSES AB Gonzalez RR, Cheuvront SN, Ely BR, Moran DS, Hadid A, Endrusick TL, Sawka MN. Sweat rate prediction equations for outdoor exercise with transient solar radiation. J Appl Physiol 112: 1300-1310, 2012. First published January 12, 2012; doi: 10.1152/japplphysiol.01056.2011.-We investigated the validity of employing a fuzzy piecewise prediction equation (PW) [Gonzalez et al. J Appl Physiol 107: 379-388, 2009] defined by sweat rate (m(sw), g.m(-2).h(-1)) = 147 + 1.527.(E-req) - 0.87.(E-max), which integrates evaporation required (E-req) and the maximum evaporative capacity of the environment (E-max). Heat exchange and physiological responses were determined throughout the trials. Environmental conditions were ambient temperature (T-a) = 16-26 degrees C, relative humidity (RH) = 51-55%, and wind speed (V) = 0.5-1.5 m/s. Volunteers wore military fatigues [clothing evaporative potential (i(m)/clo) = 0.33] and carried loads (15-31 kg) while marching 14-37 km over variable terrains either at night (N = 77, trials 1-5) or night with increasing daylight (N = 33, trials 6 and 7). PW was modified (Pw, sol) for transient solar radiation (R-sol, W) determined from measured solar loads and verified in trials 6 and 7. PW provided a valid msw prediction during night trials (1-5) matching previous laboratory values and verified by bootstrap correlation (r(bs) of 0.81, SE +/- 0.014, SEE = +/- 69.2 g.m(-2).h(-1)). For trials 6 and 7, E-req and E-max components included Rsol applying a modified equation Pw, sol, in which m(sw) = 147 + 1.527.(E-req,(sol)) - 0.87.(E-max). Linear prediction of msw = 0.72 . Pw, sol + 135 (N = 33) was validated (R-2 = 0.92; SEE = +/- 33.8 g.m(-2).h(-1)) with PW beta-coefficients unaltered during field marches between 16 degrees C and 26 degrees C Ta for m(sw) <= 700 g.m(-2).h(-1). PW was additionally derived for cool laboratory/night conditions (Ta < 20 degrees C) in which Ereq is low but Emax is high, as: PW, cool (g.m(-2).h(-1)) = 350 + 1.527.E-req - 0.87.E-max. These sweat prediction equations allow valid tools for civilian, sports, and military medicine communities to predict water needs during a variety of heat stress/exercise conditions. C1 [Cheuvront, Samuel N.; Ely, Brett R.; Endrusick, Thomas L.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Gonzalez, Richard R.] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA. [Moran, Daniel S.; Hadid, Amir] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Moran, Daniel S.] Ariel Univ, Ctr Samaria, Ariel, Israel. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil FU U.S. Army Medical Research and Material Command FX This study was funded by research contracts from the U.S. Army Medical Research and Material Command. NR 46 TC 10 Z9 10 U1 1 U2 12 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR PY 2012 VL 112 IS 8 BP 1300 EP 1310 DI 10.1152/japplphysiol.01056.2011 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 927VZ UT WOS:000302939700007 PM 22241058 ER PT J AU Mondello, S Jeromin, A Buki, A Bullock, R Czeiter, E Kovacs, N Barzo, P Schmid, K Tortella, F Wang, KK Hayes, RL AF Mondello, Stefania Jeromin, Andreas Buki, Andras Bullock, Ross Czeiter, Endre Kovacs, Noemi Barzo, Pal Schmid, Kara Tortella, Frank Wang, Kevin K. Hayes, Ronald L. TI Glial Neuronal Ratio: A Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarkers; computed tomography; diagnostic; glial neuronal ratio; traumatic brain injury ID FIBRILLARY ACIDIC PROTEIN; COMPUTED-TOMOGRAPHY FINDINGS; FOCAL CEREBRAL-ISCHEMIA; C-TERMINAL HYDROLASE; SEVERE HEAD-INJURY; AXONAL INJURY; MARKERS; BIOMARKERS; PROGNOSIS; DAMAGE AB Neurobiochemical marker levels in blood after traumatic brain injury (TBI) may reflect structural changes detected by neuroimaging. This study evaluates whether correlations between neuronal (ubiquitin carboxyterminal hydrolase-L1 [UCH-L1]) and glial (glial fibrillary acidic protein [GFAP]) biomarkers may be used as an indicator for differing intracranial pathologies after brain trauma. In 59 patients with severe TBI (Glasgow Coma Scale [GCS] score <= 8) serum samples were obtained at the time of hospital admission and analyzed for UCH-L1 and GFAP. Glial neuronal ratio (GNR) was evaluated as the ratio between GFAP and UCH-L1 concentrations. A logistic regression analysis was used to identify variables associated with type of injury. GNR had a median of 0.85 and was positively correlated with age (R = 0.45, p = 0.003). Twenty-nine patients presented with diffuse injury and 30 with focal mass lesions as assessed by CT scan at admission and classified according to the Marshall Classification. GNR was significantly higher in the focal mass lesion group compared with the diffuse injury group (1.77 versus 0.48, respectively; p = 0.003). Receiver operating characteristic curve analysis showed that GNR discriminated between types of injury (area under the curve [AUC] = 0.72; p = 0.003). GNR was more accurate earlier (<= 12 h after injury) than later (AUC = 0.80; p = 0.002). Increased GNR was independently associated with type of injury, but not age, gender, GCS score, or mechanism of injury. GNR was significantly higher in patients who died, but was not an independent predictor of death. The data from the present study indicate that GNR provides valuable information about different injury pathways, which may be of diagnostic significance. In addition, GNR may help to identify different pathophysiological mechanisms following different types of brain trauma, with implications for therapeutic interventions. C1 [Mondello, Stefania] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Hayes, Ronald L.] Banyan Biomarkers Inc, Ctr Innovat Res, Dept Clin Programs, Alachua, FL 32615 USA. [Buki, Andras; Czeiter, Endre; Kovacs, Noemi] Univ Pecs, Dept Neurosurg, Pecs, Hungary. [Bullock, Ross] Univ Miami, Dept Neurosurg, Miami, FL USA. [Barzo, Pal] Univ Szeged, Dept Neurosurg, Szeged, Hungary. [Schmid, Kara; Tortella, Frank] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD USA. [Wang, Kevin K.] Banyan Biomarkers Inc, Ctr Innovat Res, Diagnost Res & Dev Dept, Alachua, FL USA. RP Mondello, S (reprint author), Univ Florida, Dept Anesthesiol, 12085 Res Dr, Alachua, FL 32615 USA. EM smondello@banyanbio.com RI Mondello, Stefania/A-1813-2012; Czeiter, Endre/B-1404-2009; OI Mondello, Stefania/0000-0002-8587-3614; Wang, Kevin/0000-0002-9343-6473 FU Department of Defense [DAMD17-03-1-0772, DAMD17-03-1-0066]; National Institutes of Health [R01 NS049175-01, R01-NS052831-01, R01 NS051431-01]; University of Florida [N00014-06-1-1029]; Developing Competitiveness of Universities in the South Transdanubian Region [SROP-4.2.1.B-10/2/KONV-2010-0002]; Banyan Biomarkers, Inc. FX This study was primarily sponsored by Department of Defense Award numbers DAMD17-03-1-0772 and DAMD17-03-1-0066, but we also acknowledge additional fund support from National Institutes of Health grants R01 NS049175-01, R01-NS052831-01, and R01 NS051431-01, Navy grant N00014-06-1-1029 (University of Florida), and Developing Competitiveness of Universities in the South Transdanubian Region grant SROP-4.2.1.B-10/2/KONV-2010-0002.; Drs. Mondello, Buki, Bullock, Czeiter, and Barzo, are consultants of and received consulting fees from Banyan Biomarkers, Inc. Dr. Jeromin is an employee and received salary from Banyan Biomarkers, Inc. Drs. Wang and Hayes own stock and receive royalties and salaries from, and are officers of, Banyan Biomarkers Inc., and as such may benefit financially as a result of the outcomes of this research. Banyan Biomarkers, Inc. filed patent applications based upon the disclosure of this publication. Drs. Tortella, Kovacs, and Schmid report no disclosures. NR 32 TC 40 Z9 41 U1 0 U2 11 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD APR PY 2012 VL 29 IS 6 BP 1096 EP 1104 DI 10.1089/neu.2011.2092 PG 9 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 927ZL UT WOS:000302949100009 PM 22165978 ER PT J AU Rogers-Bennett, L Juhasz, C Hubbard, K Button, C AF Rogers-Bennett, Laura Juhasz, Christy Hubbard, Kristin Button, Cynthia TI MANAGEMENT PROCEDURES, BIOLOGICAL REFERENCE POINTS AND DECISION RULES FOR MANAGING AND RECOVERING ABALONE POPULATIONS IN CALIFORNIA SO JOURNAL OF SHELLFISH RESEARCH LA English DT Meeting Abstract C1 [Rogers-Bennett, Laura; Juhasz, Christy] Univ Calif Davis, Bodega Bay, CA 94923 USA. [Hubbard, Kristin] Calif Dept Fish & Game, Ft Bragg, CA 95437 USA. [Rogers-Bennett, Laura; Juhasz, Christy] Calif Dept Fish & Game, Bodega Bay, CA 94923 USA. [Button, Cynthia] Friday Harbor Labs, Friday Harbor, WA 98250 USA. NR 0 TC 0 Z9 0 U1 0 U2 9 PU NATL SHELLFISHERIES ASSOC PI GROTON PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD, GROTON, CT 06340 USA SN 0730-8000 J9 J SHELLFISH RES JI J. Shellfish Res. PD APR PY 2012 VL 31 IS 1 BP 341 EP 341 PG 1 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 926QU UT WOS:000302846800317 ER PT J AU Burns, TC Stinner, DJ Mack, AW Potter, BK Beer, R Eckel, TT Possley, DR Beltran, MJ Hayda, RA Andersen, RC Keeling, JJ Frisch, HM Murray, CK Wenke, JC Ficke, JR Hsu, JR AF Burns, Travis C. Stinner, Daniel J. Mack, Andrew W. Potter, Benjamin K. Beer, Rob Eckel, Tobin T. Possley, Daniel R. Beltran, Michael J. Hayda, Roman A. Andersen, Romney C. Keeling, John J. Frisch, Harold M. Murray, Clinton K. Wenke, Joseph C. Ficke, James R. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Microbiology and injury characteristics in severe open tibia fractures from combat SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE Open tibia fracture; combat injuries; blast injuries ID OPERATION ENDURING FREEDOM; EXTERNAL FIXATION; INFECTIOUS COMPLICATIONS; IRAQI FREEDOM; WAR INJURIES; MANAGEMENT; CLASSIFICATION; WOUNDS; INTEROBSERVER; EPIDEMIOLOGY AB BACKGROUND: Type III open tibia fractures are common combat injuries. The purpose of the study was to evaluate the effect of injury characteristics and surveillance cultures on outcomes in combat-related severe open tibia fractures. METHODS: We conducted a retrospective study of all combat-related open Gustilo and Anderson (G/A) type III diaphyseal tibia fractures treated at our centers between March 2003 and September 2007. RESULTS: One hundred ninety-two Operation Iraqi Freedom/Operation Enduring Freedom military personnel with 213 type III open tibial shaft fractures were identified. Fifty-seven extremities (27%) developed a deep infection and 47 extremities (22%) ultimately underwent amputation at an average follow-up of 24 months. Orthopedic Trauma Association type C fractures took significantly longer to achieve osseous union (p = 0.02). G/A type III B and III C fractures were more likely to undergo an amputation and took longer to achieve fracture union. Deep infection and osteomyelitis were significantly associated with amputation, revision operation, and prolonged time to union. Surveillance cultures were positive in 64% of extremities and 93% of these cultures isolated gram-negative species. In contrast, infecting organisms were predominantly gram-positive. CONCLUSIONS: Type III open tibia fractures from combat unite in 80.3% of cases at an average of 9.2 months. We recorded a 27% deep infection rate and a 22% amputation rate. The G/A type is associated with development of deep infection, need for amputation, and time to union. Positive surveillance cultures are associated with development of deep infection, osteomyelitis, and ultimate need for amputation. Surveillance cultures were not predictive of the infecting organism if a deep infection subsequently develops. (J Trauma. 2012;72:1062-1067. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Burns, Travis C.; Stinner, Daniel J.; Possley, Daniel R.; Beltran, Michael J.; Ficke, James R.; Hsu, Joseph R.] San Antonio Mil Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. [Mack, Andrew W.; Potter, Benjamin K.; Beer, Rob; Eckel, Tobin T.; Andersen, Romney C.; Keeling, John J.] Walter Reed Natl Mil Med Ctr, Dept Orthoped & Rehabil, Bethesda, MD USA. [Mack, Andrew W.; Potter, Benjamin K.; Beer, Rob; Eckel, Tobin T.; Andersen, Romney C.; Keeling, John J.] Walter Reed Natl Mil Med Ctr, Dept Orthoped & Rehabil, Washington, DC USA. [Hayda, Roman A.] Brown Univ, Warren Alpert Sch Med, Dept Orthoped, Providence, RI 02912 USA. [Murray, Clinton K.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Burns, TC (reprint author), San Antonio Mil Med Ctr, Dept Orthoped & Rehabil, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM travis.burns@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262; Potter, MD, Benjamin K./0000-0002-8771-0317 NR 31 TC 27 Z9 29 U1 1 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2012 VL 72 IS 4 BP 1062 EP 1067 DI 10.1097/TA.0b013e318241f534 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 925TO UT WOS:000302784600057 PM 22491628 ER PT J AU Hotz, G Cohn, SM Russ, WB AF Hotz, Gillian Cohn, Stephen M. Russ, Witten B. TI Annual pediatric pedestrian education does not improve pedestrian behavior SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Letter C1 [Hotz, Gillian] Univ Miami, Miller Sch Med, Dept Neurosurg, Miami, FL 33136 USA. [Cohn, Stephen M.; Russ, Witten B.] Univ Texas Hlth Sci Ctr San Antonio, USA, Inst Surg Res, San Antonio, TX 78229 USA. RP Hotz, G (reprint author), Univ Miami, Miller Sch Med, Dept Neurosurg, Miami, FL 33136 USA. NR 4 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD APR PY 2012 VL 72 IS 4 BP 1118 EP 1119 DI 10.1097/TA.0b013e31823f6c9a PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 925TO UT WOS:000302784600070 PM 22491641 ER PT J AU Ognichenko, LN Kuz'min, VE Gorb, L Hill, FC Artemenko, AG Polischuk, PG Leszczynski, J AF Ognichenko, Liudmyla N. Kuz'min, Victor E. Gorb, Leonid Hill, Frances C. Artemenko, Anatoly G. Polischuk, Pavel G. Leszczynski, Jerzy TI QSPR Prediction of Lipophilicity for Organic Compounds Using Random Forest Technique on the Basis of Simplex Representation of Molecular Structure SO MOLECULAR INFORMATICS LA English DT Article DE 2D QSPR; Lipophilicity; Simplex representation; Random Forest ID HIERARCHICAL QSAR TECHNOLOGY; ATOM-ADDITIVE METHOD; LOG-P; PARTITION-COEFFICIENTS; NITROAROMATICS; DERIVATIVES; SOLUBILITY; TOXICITY; PROGRAM; BINDING AB The relationship between the octanol-water partition coefficient for more than twelve thousand organic compounds and their structures was investigated using a QSPR approach based on Simplex Representation of Molecular Structure (SiRMS). The dataset used in our study included 10973 compounds with experimental values of lipophilicity (LogKow) for different chemical compounds. Random Forest (RF) method was used for statistical modeling at the 2D level of representation of molecular structure. Developed models are adequate and successfully validated with external test sets. Proposed models have clear interpretation due to the use of simplex representation of molecular structure and predict the LogKow values with the accuracy of the best modern models. Thus QSPR models proposed in this study represent powerful and easy-to use virtual screening tool that can be recommended for prediction of octanol-water partition coefficient. C1 [Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA. [Ognichenko, Liudmyla N.; Kuz'min, Victor E.; Artemenko, Anatoly G.; Polischuk, Pavel G.] Natl Acad Sci Ukraine, Lab Theoret Chem, Dept Mol Struct, AV Bogatsky Phys Chem Inst, UA-65080 Odessa, Ukraine. [Gorb, Leonid] Badger Tech Serv LLC, Vicksburg, MS USA. [Hill, Frances C.; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA. RP Ognichenko, LN (reprint author), Jackson State Univ, Interdisciplinary Ctr Nanotox, Dept Chem & Biochem, Jackson, MS 39217 USA. EM ogni@ukr.net FU NSF CREST Interdisciplinary Nanotoxicity Center NSF-CREST [HRD-0833178]; NSF-EPSCoR [362492-190200-01\NSFEPS-0903787]; United States Army Corps of Engineers by the USAERDC FX The authors thank for support of the NSF CREST Interdisciplinary Nanotoxicity Center NSF-CREST - Grant #HRD-0833178 and NSF-EPSCoR Award #: 362492-190200-01\NSFEPS-0903787. The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U. S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 38 TC 4 Z9 4 U1 1 U2 15 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1868-1743 J9 MOL INFORM JI Mol. Inf. PD APR PY 2012 VL 31 IS 3-4 BP 273 EP 280 DI 10.1002/minf.201100102 PG 8 WC Chemistry, Medicinal; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology SC Pharmacology & Pharmacy; Computer Science; Mathematical & Computational Biology GA 926WN UT WOS:000302862700006 PM 27477097 ER PT J AU Ter-Gabrielyan, N Fromzel, V Ryba-Romanowski, W Lukasiewicz, T Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Ryba-Romanowski, W. Lukasiewicz, T. Dubinskii, M. TI Efficient, resonantly pumped, room-temperature Er3+:GdVO4 laser SO OPTICS LETTERS LA English DT Article ID PERFORMANCE AB We report an efficient room-temperature operation of a resonantly pumped Er3+:GdVO4 laser at 1598.5nm. The maximum continuous wave (CW) output power of 3.5W with slope efficiency of 56% was achieved with resonant pumping by an Er-fiber laser at 1538.6nm. With pumping by a commercial laser diode bar stack, a quasi-CW (QCW) output of 7.7W and maximum slope efficiency of similar to 53% versus absorbed pump power were obtained. This is believed to be the first resonantly (in-band) pumped, room-temperature Er3+:GdVO4 laser. (C) 2012 Optical Society of America C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Ryba-Romanowski, W.] Inst Low Temperatures & Struct Res, PL-50422 Wroclaw, Poland. [Lukasiewicz, T.] Inst Elect Mat Technol, PL-01919 Warsaw, Poland. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.tergabrielyan.civ@mail.mil NR 7 TC 10 Z9 10 U1 0 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 1 PY 2012 VL 37 IS 7 BP 1151 EP 1153 PG 3 WC Optics SC Optics GA 925NP UT WOS:000302768300006 PM 22466178 ER PT J AU Kahlon, G Mansi, IA Banks, DE AF Kahlon, Gunjan Mansi, Ishak A. Banks, Daniel E. TI Educating Medical Students in Evidence-Based Medicine: What We Should Expect as a Starting Point for Our House Officers SO SOUTHERN MEDICAL JOURNAL LA English DT Editorial Material ID ESTROGEN PLUS PROGESTIN; TEACHING CRITICAL-APPRAISAL; SCHOOL OBJECTIVES PROJECT; POSTMENOPAUSAL WOMEN; CONTROLLED TRIAL; BREAST-CANCER; PERFORMANCE; 1ST-YEAR; HEALTH; SKILLS C1 [Banks, Daniel E.] Brooke Army Med Ctr, Dept Med, San Antonio, TX 78234 USA. Louisiana State Univ, Sch Med, Shreveport, LA USA. RP Banks, DE (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM daniel.e.banks@us.army.mil NR 26 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD APR PY 2012 VL 105 IS 4 BP 184 EP 188 DI 10.1097/SMJ.0b013e31824aeaca PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 925HR UT WOS:000302752500002 PM 22475666 ER PT J AU Mattis, SA Dawson, CN Kees, CE Farthing, MW AF Mattis, Steven A. Dawson, Clint N. Kees, Christopher E. Farthing, Matthew W. TI Numerical modeling of drag for flow through vegetated domains and porous structures SO ADVANCES IN WATER RESOURCES LA English DT Article DE Vegetation; Upscaling; Porous media; Computational hydraulics ID LARGE-EDDY-SIMULATION; OPEN-CHANNEL FLOW; TURBULENT-FLOW; PLANT CANOPY; REYNOLDS-NUMBER; MEAN FLOW; RESISTANCE; DISPERSION; FOREST; MEDIA AB In this paper, we study flow through vegetated wetlands using high resolution computational models to describe the flow. The goal is to describe drag characteristics of this flow at the large scales as a function of Reynolds number. This work is of importance to scientists and engineers dealing with wetland health and restoration, inland flooding due to tropical storms and hurricanes, and river lining projects. The existence of vegetation affects the flow resistance, which is a major factor in determining velocity and water level distribution in wetlands. For low Reynolds numbers, wetlands behave similarly to porous media, where it is well-known that Stokes flow at the micro-scale can be upscaled through homogenization to Darcy's Law at the macro-scale. As Reynolds number increases moderately, small-scale drag effects can be captured by adding a quadratic and/or cubic term to the Darcy equation; the so-called Darcy-Forchheimer model. For higher Reynolds numbers, Stokes equation is no longer a valid approximation, and full Navier-Stokes models must be used. We utilize large eddy simulation (LES) to study vegetative drag at high Reynolds numbers. The numerical simulations in this paper are performed using the Proteus Toolkit, which is under development by Kees and Farthing at ERDC. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Mattis, Steven A.; Dawson, Clint N.] Univ Texas Austin, Inst Computat Engn & Sci, Univ Stn CO200 1, Austin, TX 78712 USA. [Kees, Christopher E.; Farthing, Matthew W.] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Mattis, SA (reprint author), Univ Texas Austin, Inst Computat Engn & Sci, Univ Stn CO200 1, Austin, TX 78712 USA. EM steven@ices.utexas.edu; clint@ices.utexas.edu; christopher.e.kees@usace.army.mil; matthew.w.farthing@usace.army.mil FU USACE [W912HZ-08-C-0050]; National Science Foundation [DMS-0915223] FX Co-authors Dawson and Mattis acknowledge support for this research from USACE Contract W912HZ-08-C-0050 and National Science Foundation grant DMS-0915223. Co-authors Kees and Farthing acknowledge support from the USACE Military Engineering 6.1 Research Program project "Particle-Scale Distribution of Soil Moisture in Porous Materials." The authors acknowledge the NSF Teragrid and the Texas Advanced Computing Center (TACC) at The University of Texas at Austin for providing HPC resources that have contributed to the research results reported within this paper. URL: http://www.tacc.utexas.edu. Permission was granted by the Chief of Engineers to publish this information. NR 55 TC 14 Z9 15 U1 2 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1708 J9 ADV WATER RESOUR JI Adv. Water Resour. PD APR PY 2012 VL 39 BP 44 EP 59 DI 10.1016/j.advwatres.2012.01.002 PG 16 WC Water Resources SC Water Resources GA 920TJ UT WOS:000302430400005 ER PT J AU Wiles, GC Mennett, CR Jarvis, SK D'Arrigo, RD Wiesenberg, N Lawson, DE AF Wiles, Gregory C. Mennett, Colin R. Jarvis, Stephanie K. D'Arrigo, Rosanne D. Wiesenberg, Nicholas Lawson, Daniel E. TI Tree-ring investigations into changing climatic responses of yellow-cedar, Glacier Bay, Alaska SO CANADIAN JOURNAL OF FOREST RESEARCH-REVUE CANADIENNE DE RECHERCHE FORESTIERE LA English DT Article ID TOLERANCE; FORESTS AB Yellow-cedar (Callitropsis nootkatensis (D. Don) Orsted ex D.P. Little) is in a century-long decline coinciding with the end of the Little Ice Age (LIA). The leading hypothesis explaining this decline is a decrease in insulating snowpack due to warming and increased susceptibility to damaging frosts in the root zone. A ring-width series from yellow-cedar on Excursion Ridge (260 m a.s.l.) in Glacier Bay National Park and Preserve, Alaska, and another from trees on Pleasant Island (150 m a.s.l.) in the Tongass National Forest in Icy Strait were compared with regional monthly temperature and precipitation data from Sitka, Alaska, to investigate the changing growth response to temperature at these sites. Comparisons with monthly temperatures from 1832 to 1876 during the end of the Little Ice Age show that the high-elevation Excursion Ridge and the low-elevation Pleasant Island sites strongly favored warmer January through July temperatures. Both tree populations have markedly changed their response from a positive to a strong negative correlation with January through July temperatures since 1950. This strong negative response to warming by the yellow-cedar together with a positive relationship with total March and April precipitation suggests that these yellow-cedar sites may be susceptible to decline. Furthermore, these analyses are consistent with the hypothesis that the yellow-cedar decline is linked to decreased snowpack. C1 [Wiles, Gregory C.; Mennett, Colin R.; Jarvis, Stephanie K.; Wiesenberg, Nicholas] Coll Wooster, Dept Geol, Wooster, OH 44691 USA. [D'Arrigo, Rosanne D.] Lamont Doherty Earth Observ, Tree Ring Lab, Palisades, NY 10964 USA. [Lawson, Daniel E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Wiles, GC (reprint author), Coll Wooster, Dept Geol, 1189 Beall Ave, Wooster, OH 44691 USA. EM gwiles@wooster.edu FU National Science Foundation [ATM-0902799]; National Geographic Society FX We thank Glacier Bay National Park and Preserve and the National Forest Service (US Forest Service Special Use Permit FS-2700-4) for allowing us to sample the yellow-cedar used in this study. This work was supported by the National Science Foundation (ATM-0902799). We are grateful to the National Park Service and Wayne Howell for logistical support. Part of the Excursion Ridge chronology sampling was made possible by a grant from the National Geographic Society. Reviews by Tom Maertens and an anonymous reviewer greatly improved this work. This paper represents Lamont-Doherty Earth Observatory contribution 7525. NR 27 TC 2 Z9 2 U1 0 U2 13 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0045-5067 J9 CAN J FOREST RES JI Can. J. For. Res.-Rev. Can. Rech. For. PD APR PY 2012 VL 42 IS 4 BP 814 EP 819 DI 10.1139/X2012-028 PG 6 WC Forestry SC Forestry GA 918CL UT WOS:000302226700016 ER PT J AU Pendleton, L Mohn, C Vaughn, RK King, P Zoulas, JG AF Pendleton, Linwood Mohn, Craig Vaughn, Ryan K. King, Philip Zoulas, James G. TI SIZE MATTERS: THE ECONOMIC VALUE OF BEACH EROSION AND NOURISHMENT IN SOUTHERN CALIFORNIA SO CONTEMPORARY ECONOMIC POLICY LA English DT Article ID MODELS AB Despite the widespread use of nourishment in California, few studies estimate the welfare benefits of increased beach width. This paper relies on panel data funded by National Oceanic and Atmospheric Administration and other agencies. Beach choices of respondents were combined with beach attribute data to reveal how changes in width affect choice and the economic value of beach visits. We use a random-utility approach to show that the value of beach width varies for different types of beach uses: water contact, sand-, and pavement-based activities. We also find that the marginal value of beach width depends on initial beach width. (JEL Q50) C1 [Pendleton, Linwood] Duke Univ, Nicholas Inst Environm Policy Solut, Beaufort, NC 28516 USA. [Pendleton, Linwood] NOAA, Silver Spring, MD 20910 USA. [Mohn, Craig] Cascade Econometr, Sammamish, WA 98075 USA. [Vaughn, Ryan K.] Univ Calif Los Angeles, Dept Econ, Los Angeles, CA 90095 USA. [King, Philip] San Francisco State Univ, Dept Econ, San Francisco, CA 94132 USA. [Zoulas, James G.] USA, Corps Engn, San Francisco, CA 94103 USA. RP Pendleton, L (reprint author), Duke Univ, Nicholas Inst Environm Policy Solut, Beaufort, NC 28516 USA. EM pendleton@duke.edu; craigmohn@earthlink.net; rkvaughn@ucla.edu; pking@sfsu.edu; James.G.Zoulas@usace.army.mil NR 13 TC 10 Z9 10 U1 1 U2 16 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1074-3529 J9 CONTEMP ECON POLICY JI Contemp. Econ. Policy PD APR PY 2012 VL 30 IS 2 BP 223 EP 237 DI 10.1111/j.1465-7287.2011.00257.x PG 15 WC Economics; Public Administration SC Business & Economics; Public Administration GA 923HN UT WOS:000302610500006 ER PT J AU Quartey, B Dunne, J Cryer, C AF Quartey, Benjamin Dunne, James Cryer, Chad TI Acute Appendicitis Post Liver Transplant: A Case Report and Literature Review SO EXPERIMENTAL AND CLINICAL TRANSPLANTATION LA English DT Review DE Appendix; Inflammation; After-liver transplant; Laparoscopy; Appendectomy ID DIAGNOSIS; ADULTS AB Although acute appendicitis is common, reported cases after orthotopic liver transplant are rare. A 29-year-old woman presented to the emergency department with right lower-quadrant pain and mild leukocytosis 2 years after having a liver transplant. A computed tomography scan revealed an inflamed appendix. On operation, an injected appendix was noted, and she underwent an uncomplicated laparoscopic appendectomy. Histology confirmed the diagnosis and her postoperative course was unremarkable. Owing to the rarity of these cases and paucity of knowledge on management, a high index of suspicion and immediate intervention are required to prevent major complications. This case is the first successful laparoscopic appendectomy after liver transplant ever reported. C1 [Dunne, James] Natl Naval Med Ctr, Natl Capital Consortium, Dept Gen Surg Trauma & Crit Care, Bethesda, MD USA. [Cryer, Chad] Walter Reed Army Med Ctr, Natl Capital Consortium, Dept Gen Surg, Washington, DC 20307 USA. RP Quartey, B (reprint author), 8901 Wisconsin Ave, Bethesda, MD 20899 USA. EM Benjamin.Quartey@med.navy.mil NR 10 TC 2 Z9 2 U1 0 U2 2 PU BASKENT UNIV PI ANKARA PA TASKENT CADDESI NO 77, KAT 4, BAHCELIEVLER, ANKARA, 06490, TURKEY SN 1304-0855 J9 EXP CLIN TRANSPLANT JI Exp. Clin. Transplant. PD APR PY 2012 VL 10 IS 2 BP 183 EP 185 DI 10.6002/ect.2011.0124 PG 3 WC Transplantation SC Transplantation GA 921ZR UT WOS:000302517100019 PM 22432766 ER PT J AU Dabisch, P Yeager, J Kline, J Klinedinst, K Welsch, A Pitt, ML AF Dabisch, Paul Yeager, John Kline, Jamie Klinedinst, Katie Welsch, Andrew Pitt, Margaret L. TI Comparison of the efficiency of sampling devices for aerosolized Burkholderia pseudomallei SO INHALATION TOXICOLOGY LA English DT Article DE Aerosol sampling; Burkholderia pseudomallei; melioidosis; aerosol ID COLLECTION EFFICIENCY; BIOAEROSOL SAMPLERS; INFECTION; BACTERIA; LIQUID AB Previous studies have demonstrated that aerosol sampling devices can have deleterious effects on bacteria due to stresses intrinsic to the sampling processes. Although a significant amount of work has been carried out to develop animal models of inhalational melioidosis, little information has been reported on the effects of the aerosol sampling devices on the causative bacterium, Burkholderia pseudomallei. The aim of this study was to compare the efficiencies for collection of aerosolized bacteria in three sampling devices that have been used in studies utilizing aerosolized B. pseudomallei. The data from this study demonstrate the equivalence of the Mercer impactor, gelatin filter, and model 7541 AGI for sampling respirable aerosols containing B. pseudomallei across a range of aerosol concentrations. It was also determined that the retention efficiency of gelatin filters for culturable B. pseudomallei was near unity, suggesting that desiccation of collected material did not occur for the short sampling period tested. The retention efficiency of the model 7541 AGI for culturable B. pseudomallei was significantly less than unity, and it was determined that this decrease was likely due to the stresses associated with repetitive sampler bubbling. The results of this study also confirmed the results of previous studies on the deleterious effects of the Collison nebulizer on microorganisms and extended these data to include B. pseudomallei. C1 [Dabisch, Paul; Yeager, John; Kline, Jamie; Pitt, Margaret L.] USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Klinedinst, Katie; Welsch, Andrew] KeAki Technol LLC, Frederick, MD USA. RP Dabisch, P (reprint author), USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM paul.a.dabisch@us.army.mil FU Transformational Medical Technologies Program [Plan TMTI0033_09_RD_T] FX The research described herein was sponsored by the Transformational Medical Technologies Program, Plan TMTI0033_09_RD_T. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 18 TC 3 Z9 3 U1 0 U2 8 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0895-8378 J9 INHAL TOXICOL JI Inhal. Toxicol. PD APR PY 2012 VL 24 IS 5 BP 247 EP 254 DI 10.3109/08958378.2012.666682 PG 8 WC Toxicology SC Toxicology GA 922QU UT WOS:000302563800001 PM 22486343 ER PT J AU Grzegorczyk, TM Fernandez, JP Shubitidze, F O'Neill, K Barrowes, BE AF Grzegorczyk, Tomasz M. Fernandez, Juan Pablo Shubitidze, Fridon O'Neill, Kevin Barrowes, Benjamin E. TI Subsurface electromagnetic induction imaging for unexploded ordnance detection SO JOURNAL OF APPLIED GEOPHYSICS LA English DT Article DE Unexploded ordnance; Electromagnetic induction; Subsurface imaging; Gauss-Newton method ID ARBITRARY EXCITATION; UXO DISCRIMINATION; IDENTIFICATION; CLASSIFICATION; LANDMINES; MODELS AB Detection and classification of unexploded ordnance based on electromagnetic induction have made tremendous progress over the last few years, to the point that not only more realistic terrains are being considered but also more realistic questions - such as when to stop digging - are being posed. Answering such questions would be easier if it were somehow possible to see under the surface. In this work we propose a method that, within the limitations on resolution imposed in the available range of frequencies, generates subsurface images from which the positions, relative strengths, and number of targets can be read off at a glance. The method seeds the subsurface with multiple dipoles at known locations that contribute collectively but independently to the measured magnetic field. The polarizabilities of the dipoles are simultaneously updated in a process that seeks to minimize the mismatch between computed and measured fields over a grid. In order to force the polarizabilities to be positive we use their square roots as optimization variables, which makes the problem nonlinear. The iterative update process guided by a Jacobian matrix discards or selects dipoles based on their influence on the measured field. Preliminary investigations indicate a fast convergence rate and the ability of the algorithm to locate multiple targets based on data from various state-of-the-art electromagnetic induction sensors. (C) 2012 Elsevier B.V. All rights reserved. C1 [Grzegorczyk, Tomasz M.] Delpsi LLC, Newton, MA 02458 USA. [Shubitidze, Fridon; Barrowes, Benjamin E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [O'Neill, Kevin; Barrowes, Benjamin E.] US Army Corps Engineers, ERDC CRREL, Hanover, NH 03755 USA. RP Grzegorczyk, TM (reprint author), Delpsi LLC, Newton, MA 02458 USA. EM tomasz.grzegorczyk@delpsi.com FU U.S. Army Corps of Engineers, Humphreys Engineer Center [W912HQ-11-C-0072]; U.S. Army Corps of Engineers, Engineer Research and Development Center, Cold Regions Research and Engineering Laboratory [W913E5-11-C-0014, W913E5-10-C-0016] FX This material is based upon work supported by the U.S. Army Corps of Engineers, Humphreys Engineer Center Support Activity, under Contract No. W912HQ-11-C-0072 and the U.S. Army Corps of Engineers, Engineer Research and Development Center, Cold Regions Research and Engineering Laboratory, under Contracts Nos. W913E5-11-C-0014 and W913E5-10-C-0016. The authors would like to thank S. Jensen-Segal and I. Shamatava of Sky Research for providing the MPV data of Section 3.2.2, M. Prouty of Geometrics, Inc., D. C. George of G&G Sciences and D. D. Snyder of Snyder Geoscience for providing the MetalMapper data of Section 3.2.3, and D. A. Steinhurst of Nova Research for providing the TEMTADS data of Section 3.2.1. NR 50 TC 6 Z9 6 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-9851 EI 1879-1859 J9 J APPL GEOPHYS JI J. Appl. Geophys. PD APR PY 2012 VL 79 BP 38 EP 45 DI 10.1016/j.jappgeo.2011.12.014 PG 8 WC Geosciences, Multidisciplinary; Mining & Mineral Processing SC Geology; Mining & Mineral Processing GA 921AH UT WOS:000302449900005 ER PT J AU Jackson, K Key, C Fontaine, M Pope, R AF Jackson, Keith Key, Charles Fontaine, Michelle Pope, Richard TI Recurrence of a Giant Cell Tumor of the Hand After 42 Years: Case Report SO JOURNAL OF HAND SURGERY-AMERICAN VOLUME LA English DT Article DE Giant cell; recurrent; tumor ID BONE; EXPRESSION AB Giant cell tumors of bone in the hand are rare. We present a case of a recurrent giant cell tumor in the metacarpal 42 years after intralesional excision and autogenous bone grafting. The possibility of recurrent disease should be considered in the evaluation of any patient presenting with new onset of pain at the site of a previously addressed giant cell tumor. Management of these recurrent lesions should include wide excision with digit salvaging procedures or ray amputation owing to the high rates of treatment failures seen with marginal excision. (J Hand Surg 2012;37A:783-786. Published by Elsevier Inc. on behalf of the American Society for Surgery of the Hand.) C1 [Jackson, Keith; Key, Charles; Fontaine, Michelle; Pope, Richard] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Jackson, K (reprint author), Dwight D Eisenhower Army Med Ctr, 300 E Hosp Rd, Ft Gordon, GA USA. EM lynn.jackson9@gmail.com NR 15 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0363-5023 J9 J HAND SURG-AM JI J. Hand Surg.-Am. Vol. PD APR PY 2012 VL 37A IS 4 BP 783 EP 786 DI 10.1016/j.jhsa.2011.12.005 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 925JA UT WOS:000302756300023 PM 22305433 ER PT J AU Yoo, JH Flatau, AB AF Yoo, Jin-Hyeong Flatau, Alison B. TI A bending-mode galfenol electric power harvester SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE energy harvesting; magnetostrictive; galfenol ID FE-GA; ALLOYS AB Iron-gallium alloys (galfenol) are promising transducer materials that combine high magnetostriction, desirable mechanical properties, high permeability, and a wide operational temperature range. In this study, we present results from a proof-of-concept prototype energy harvester that produces an output voltage proportional to the load-induced bending of the galfenol element caused by a base acceleration of the device. The device consists of a polycrystalline galfenol strip bonded to an aluminum cantilever beam, which has an effective length of 35.81 mm. Two brass pieces, each containing a permanent magnet, are used to mass load each end of the beam and to provide a magnetic bias field through the galfenol strip. The voltage induced in an induction coil closely wound around the cantilever beam captures the time rate of change of magnetic flux within the galfenol strip as the beam vibrates. The first bending-mode resonant frequency of the device was 223 Hz. The power generated from the prototype when subjected to a Ig acceleration at 222 Hz was 2.2 mW (root mean square), which corresponded to an efficiency of more than 60% for the electrical power output per unit mechanical power input to the harvester. C1 [Yoo, Jin-Hyeong] USA, Res Lab, RDRL VTM, Aberdeen Proving Ground, MD 21005 USA. [Flatau, Alison B.] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA. RP Yoo, JH (reprint author), USA, Res Lab, RDRL VTM, Bldg 4603, Aberdeen Proving Ground, MD 21005 USA. EM jinhyeong.yoo@us.army.mil FU ONR MURI [N000 140610530] FX This work was supported by ONR MURI Grant N000 140610530. NR 13 TC 13 Z9 14 U1 2 U2 33 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD APR PY 2012 VL 23 IS 6 BP 647 EP 654 DI 10.1177/1045389X12436729 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 922RE UT WOS:000302564800003 ER PT J AU Seidule, JT AF Seidule, James Tyrus TI "Treason is Treason" Civil War Memory at West Point, 1861-1902 SO JOURNAL OF MILITARY HISTORY LA English DT Article AB The United States Military Academy educated the most successful and iconic Confederate generals. How did West Point reconcile the memory of Confederate graduates who, while famed for their martial prowess, fought against the U.S. Army? In the Gilded Age, West Point neither forgot nor forgave Confederate graduates for fighting against the U.S. Army. The memory of wartime chaos, Congressional criticism, and Confederate graduates' betrayal left the Military Academy feeling defensive. This defensiveness led West Point to create a series of written and stone memorials, mainly in the 1890s, highlighting West Point's role in saving the Union. All of the memorials excluded Confederate graduates. C1 US Mil Acad, West Point, PA USA. RP Seidule, JT (reprint author), US Mil Acad, West Point, PA USA. NR 96 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2012 VL 76 IS 2 BP 427 EP 452 PG 26 WC History SC History GA 920XZ UT WOS:000302443900005 ER PT J AU Andrade, DW Allison, WT AF Andrade, Dale W. Allison, William Thomas TI Westmoreland: The General Who Lost Vietnam SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Andrade, Dale W.] USA, Ctr Mil Hist, Washington, DC 20310 USA. [Allison, William Thomas] Georgia So Univ, Statesboro, GA 30460 USA. RP Andrade, DW (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2012 VL 76 IS 2 BP 549 EP 552 PG 4 WC History SC History GA 920XZ UT WOS:000302443900012 ER PT J AU Bjorge, G AF Bjorge, Gary TI A Springboard to Victory: Shandong Province and Chinese Communist Military and Financial Strength, 1937-1945. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bjorge, Gary] US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Bjorge, G (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2012 VL 76 IS 2 BP 592 EP 593 PG 2 WC History SC History GA 920XZ UT WOS:000302443900037 ER PT J AU Rush, RS AF Rush, Robert Sterling TI Advance and Destroy: Patton as Commander in the Bulge. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rush, Robert Sterling] USA, Ctr Mil Hist, Washington, DC USA. RP Rush, RS (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 2012 VL 76 IS 2 BP 611 EP 612 PG 2 WC History SC History GA 920XZ UT WOS:000302443900050 ER PT J AU Estes, TJ Clarke, JU McGrath, CJ AF Estes, Trudy J. Clarke, Joan U. McGrath, Christian J. TI Confined disposal facility characterization for beneficial reuse of dredged material: a case study to demonstrate a structured approach to sampling and data analysis SO JOURNAL OF SOILS AND SEDIMENTS LA English DT Article DE Beneficial reuse; Confined disposal facility; Dredged material characterization; Regulatory guideline comparisons; Statistical tools ID POLYCYCLIC AROMATIC-HYDROCARBONS; ENVIRONMENTAL BLACK CARBON; PHENANTHRENE SORPTION; MODEL; SOIL; PAH; QUANTIFICATION; SEDIMENTS; SORBATE; OIL AB Confined disposal facilities (CDFs) are widely used for disposal of navigation dredged material, but many are running out of capacity. Removal of dredged material for beneficial use offers potential for sustainable operations, but requires characterization with a high degree of confidence. Few data are available to inform characterization efforts in these artificial depositional environments; thus, a CDF case study was used to demonstrate a structured approach to sampling and data analysis. Selected data analysis procedures were applied to data collected from a CDF, with the objective of illustrating the utility of these procedures in (1) maximizing information obtained from limited data and (2) assessing the adequacy of the data in terms of estimating parameters of interest. In this case, the data were used to estimate the abundance of the desired fraction (sand), the contaminant levels in the sand and residual fractions, and the uncertainty of the parameters measured. From the outcome of this analysis, a stepwise approach to CDF characterization and data analysis was developed. The available dataset proved sufficient to estimate the distribution of sand in the CDF, although estimate reliability was constrained by the small number of samples and the lack of samples along the western facility boundary. Soot, organic carbon, and oil and grease were statistically significant regressors for many contaminants of concern; however, data were too limited and variable to permit prediction of contaminant concentrations in unanalyzed samples on the basis of the sorptive phases. A contour surface of benzo(a)pyrene concentration was generated to illustrate the utility in identifying areas of the CDF that may be problematic with respect to meeting regulatory criteria or guidelines for beneficial use; such areas may require additional processing to remove more highly contaminated fractions. Of the graphical data analysis techniques evaluated, the most useful were: the aerial site view showing sample locations and per cent sand; the ternary diagram comparing sample characteristics; the contour map and the sand isopach map, representing aerial variation of sand thickness; and the depiction of contaminant concentrations as a contour surface. The predictive capability of the data was limited, but may have been aided with the addition of density fractionation and a larger dataset. C1 [Estes, Trudy J.; Clarke, Joan U.; McGrath, Christian J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Estes, TJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Trudy.J.Estes@usace.army.mil FU US Army Corps of Engineers FX The authors thank Dr. Richard E. Saichek of the US Army Corps of Engineers Chicago District, Environmental Engineering Section, and Dr. Jeff Davis, US Army ERDC, Environmental Laboratory, for helpful comments on this manuscript. The Chicago Area CDF dataset was supplied by the Chicago District. Funding was provided by the US Army Corps of Engineers Dredging Operations and Engineering Research Program. Permission was granted by the Chief of Engineers to publish this material. NR 33 TC 0 Z9 0 U1 0 U2 9 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1439-0108 J9 J SOIL SEDIMENT JI J. Soils Sediments PD APR PY 2012 VL 12 IS 4 BP 636 EP 651 DI 10.1007/s11368-012-0474-4 PG 16 WC Environmental Sciences; Soil Science SC Environmental Sciences & Ecology; Agriculture GA 920PG UT WOS:000302418100016 ER PT J AU Baylot, EA Mason, GL Green, JG Berney, ES AF Baylot, E. Alex Mason, George L. Green, John G. Berney, Ernest S. TI Predicting the stability of low volume road embankments in contingency areas SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Low volume road; Embankment; Traffic; Heavy vehicles; Trafficability; Soil strength; Stability AB The US Army often operates heavy vehicles in rural areas, operating on low-volume roads having limited load carrying capacity. Many of these roads, such as the ones on the outskirts of Baghdad, have been raised to prevent flooding from nearby canals or irrigated fields. Sections of the roads have collapsed under the weight of armored vehicles, resulting in injuries and even fatalities. For the selected area studied, 21/2% of the low-volume road sections were determined to be high risk given typical wheel loads of heavy vehicles for soil strength conditions modeled as low. The goal of the research was to develop a method for rapidly evaluating the stability of a road based on soil conditions, wheel load, and the dimensions of a vehicle. A model for road stability was developed to assist in performing analysis of the canal roads outside of Baghdad. This analysis was then used to create maps and charts characterizing road stability to assist the drivers. The procedure described in this paper can be used to evaluate elevated roads in other parts of the world. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Baylot, E. Alex; Mason, George L.; Green, John G.; Berney, Ernest S.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. RP Baylot, EA (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM alex.baylot@usace.army.mil FU US Army Infantry Center; Army Capabilities Integration Center, US Army Training and Doctrine Command; Defense Safety Over-sight Council FX Permission to publish was granted by Director, Geotechnical & Structures Laboratory. The study was conducted in support of the US Army Infantry Center and the Army Capabilities Integration Center, US Army Training and Doctrine Command. Messrs Tom Stafford and William McLaughlin, Combat Developments Specialists, US Army Infantry Center, were the technical points of contact. Data defining the number and types of mishaps of the MRAP in theater were obtained from Mr. Alfred Rice, working with the Pentagon's Deployments and Operations Task Force under the auspices of the Defense Safety Over-sight Council. Initial findings were presented at the Joint 9th Asia-Pacific ISTVS Conference and Annual Meeting of Japanese Society for Terramechanics [9]. NR 9 TC 1 Z9 1 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD APR PY 2012 VL 49 IS 2 BP 95 EP 101 DI 10.1016/j.jterra.2012.01.002 PG 7 WC Engineering, Environmental SC Engineering GA 924BY UT WOS:000302666900004 ER PT J AU Coldren, RL Brett-Major, DM Hickey, PW Garges, E Weina, PJ Corrigan, P Quinnan, G AF Coldren, Rodney L. Brett-Major, David M. Hickey, Patrick W. Garges, Eric Weina, Peter J. Corrigan, Paula Quinnan, Gerald TI Tropical Medicine Training in the Department of Defense SO MILITARY MEDICINE LA English DT Editorial Material C1 [Coldren, Rodney L.; Hickey, Patrick W.; Quinnan, Gerald] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Brett-Major, David M.] USN, Med Personnel Training & Educ Command, Bethesda, MD 20889 USA. [Garges, Eric; Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Corrigan, Paula] USAF, Sch Aerosp Med, Wright Patterson AFB, OH 45433 USA. RP Coldren, RL (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. RI Weina, Peter/A-2120-2011; Valle, Ruben/A-7512-2013 NR 2 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 361 EP 363 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300004 PM 22594123 ER PT J AU Gubata, ME Oetting, AA Weber, NS Feng, XS Cowan, DN Niebuhr, DW AF Gubata, Marlene E. Oetting, Alexis A. Weber, Natalya S. Feng, Xiaoshu Cowan, David N. Niebuhr, David W. TI A Noncognitive Temperament Test to Predict Risk of Mental Disorders and Attrition in U.S. Army Recruits SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Joint Accession Research and Best Practices Symposium (JAR and BPS) CY MAY 03-05, 2011 CL Colorado Springs, CO ID MILITARY AB U.S. military accession mental health screening includes cognitive testing and questions regarding the applicants' past mental health history. This process relies on applicants' knowledge of and willingness to disclose symptoms and conditions. Applicants have a strong incentive to appear qualified, which has resulted in a long history of frequent mental health conditions presenting during recruit training. Objective: To assess the predictive value of a pre-enlistment noncognitive temperament test score for risk of mental disorders and attrition in the first year of service. Methods: A retrospective cohort study was conducted on non-high school diploma U.S. Army active duty recruits who took the Assessment of Individual Motivation (AIM). Multivariate logistic regression models were used to determine associations between AIM score quintiles, mental disorders, and attrition. Results: AIM scorers in the lowest quintile were at increased risk for a mental disorder (OR, 1.44; 95% CI, 1.35-1.53) and of discharge (OR, 1.65; 95% CI, 1.44-1.68) compared to AIM scorers in the highest quintile, with significant linear trends for decreased risk with increasing AIM score. Conclusions: AIM offers the potential to improve screening of military applicants and reduce mental disorders and attrition in new recruits beyond the current process. C1 [Gubata, Marlene E.; Oetting, Alexis A.; Weber, Natalya S.; Feng, Xiaoshu; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, Silver Spring, MD 20910 USA. [Oetting, Alexis A.; Feng, Xiaoshu; Cowan, David N.] Allied Technol Grp, Rockville, MD 20850 USA. RP Gubata, ME (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. NR 9 TC 2 Z9 2 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 374 EP 379 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300007 PM 22594126 ER PT J AU Millikan, AM Bell, MR Gallaway, MS Lagana, MT Cox, AL Sweda, MG AF Millikan, Amy M. Bell, Michael R. Gallaway, M. Shayne Lagana, Maureen T. Cox, Anthony L. Sweda, Michael G. TI An Epidemiologic Investigation of Homicides at Fort Carson, Colorado: Summary of Findings SO MILITARY MEDICINE LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; VIOLENT BEHAVIOR; COMBAT EXPOSURE; RISK-FACTORS; LIFE STRESS; AGGRESSION; SUICIDE; TRAUMA; EXPERIENCES AB In response to an apparent clustering of homicides at Fort Carson, Colorado, the U.S. Army Public Health Command (formerly the U.S. Army Center for Health Promotion and Preventive Medicine) Behavioral and Social Health Outcomes Program conducted a multidisciplinary epidemiologic consultation to identify factors contributing to violent behavior among soldiers at Fort Carson. This article summarizes the findings of the epidemiologic consultation report as provided to the Secretary of the Army and the Fort Carson Senior Mission Commander and released in its entirety publicly July 2009 and elaborates on the mixed-methods analytic approach used to study a complex behavioral issue at the community level. To aid in answering the key study questions, six study arms were designed and carried out: (I) index case analysis, (2) confinee interviews, (3) analysis of installation-level trends, (4) retrospective cohort analysis, (5) soldier focus groups and interviews, and (6) aggression risk factors survey. Although not conclusive, the findings suggest a combination of individual, unit, and environmental factors converged to increase the risk of violent behaviors, which made clustering of negative outcomes more likely. C1 [Millikan, Amy M.; Gallaway, M. Shayne; Lagana, Maureen T.] USA, Publ Hlth Command, Behav & Social Hlth Outcomes Program, Gunpowder, MD 21010 USA. [Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Cox, Anthony L.] USA, Behav Hlth Div, Med Command, Ft Sam Houston, TX 78324 USA. [Sweda, Michael G.] Walter Reed Natl Mil Med Ctr, Arlington, VA 22009 USA. RP Millikan, AM (reprint author), USA, Publ Hlth Command, Behav & Social Hlth Outcomes Program, 5158 Blackhawk Rd,Bldg E-1570, Gunpowder, MD 21010 USA. FU Office of the Army Surgeon General FX We thank the Office of the Army Surgeon General for their support of this study and their expertise regarding interpretation and communication of our findings in both the public and scientific arenas. We also acknowledge the assistance of Drs. Freddy Paniagua and Sandra A. Black in the preparation and editing of this manuscript. Special thanks, also, to staff from the USAPHC Health Promotion and Wellness Portfolio for assisting with focus group facilitation and data analysis. NR 29 TC 8 Z9 8 U1 1 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 404 EP 411 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300011 PM 22594130 ER PT J AU Piccirillo, AL Gubata, ME Blandford, CD Packnett, ER Cowan, DN Niebuhr, DW AF Piccirillo, Amanda L. Gubata, Marlene E. Blandford, Caitlin D. Packnett, Elizabeth R. Cowan, David N. Niebuhr, David W. TI Temporary Disability Retirement Cases: Variations in Time to Final Disposition and Disability Rating by Service and Medical Condition SO MILITARY MEDICINE LA English DT Article ID ARMY; MILITARY AB Objective: Service members undergoing disability evaluation are placed on the temporary disability retirement list (TDRL) when their disabling medical condition(s) may change in severity over time. Information is sparse on the epidemiology of the TDRL population and factors influencing time spent on the TDRL or changes in compensation ratings before final disability outcome. Methods: A cross-sectional study was conducted on U.S. Army, Navy, and Marine Corps personnel placed on the TDRL between fiscal years 2005 to 2009. Results: Approximately 85% of cases were finalized at first re-evaluation and more than 75% were permanently retired. Overall, about 50% of cases retained the same disability rating throughout the process. Cases with medical conditions within two or more body systems were more likely to be permanently retired and receive a change in disability rating than those with medical condition(s) within a single body system. Conclusions: Most cases retained the same disability rating and were permanently retired by the first re-evaluation. Important areas of future research include cost-benefit analyses to determine if length of time currently allowable on the TDRL can be shortened or if repeated evaluations are necessary and exploration of specific medical conditions likely to change in severity over time. C1 [Piccirillo, Amanda L.; Gubata, Marlene E.; Blandford, Caitlin D.; Packnett, Elizabeth R.; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD 20910 USA. [Piccirillo, Amanda L.; Blandford, Caitlin D.; Packnett, Elizabeth R.; Cowan, David N.] Allied Technol Grp, Rockville, MD USA. RP Piccirillo, AL (reprint author), Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. FU Defense Health Program FX We would like to thank Ms. Janice K. Gary, Walter Reed Army Institute of Research, Division of Preventive Medicine staff for administrative support in preparation of the manuscripts. This study was funded by the Defense Health Program NR 9 TC 4 Z9 4 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 417 EP 422 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300013 PM 22594132 ER PT J AU McAvin, JC Swanson, KI Chan, AST Quintana, M Coleman, RE AF McAvin, James C. Swanson, Katherine I. Chan, Adeline S. T. Quintana, Miguel Coleman, Russell E. TI Leishmania Detection in Sand Flies Using a Field-Deployable Real-Time Analytic System SO MILITARY MEDICINE LA English DT Article ID US MILITARY OPERATIONS; TALLIL AIR BASE; VISCERAL LEISHMANIASIS; INFECTION; DIAGNOSIS; DONOVANI; IRAQ; A2; IMPACT AB We describe here the development and evaluation of advanced vector surveillance analytic technologies for real-time leishmaniasis risk assessment. Leishmania genus and visceral leishmaniasis causative agent-specific dual fluorogenic-probe hydrolysis (TaqMan), thermally stable (freeze-dried) polymerase chain reaction assays were developed using field-durable analytic instrumentation. In laboratory testing with a panel of diverse Leishmania species from culture and infected sand flies, the sensitivity and specificity of both assays were 100% concordant with DNA sequencing. In specificity testing with Leishmania genetic near neighbors, clinically significant organisms, and human genomic DNA, no detectable fluorescence above background was observed. Field evaluation was conducted in southern Iraq using wild sand flies. In field testing, Leishmania genus assay was 100% sensitive and 96% specific with a single false-positive result. The visceral leishmaniasis genotype assay was 100% sensitive and 100% specific compared to DNA sequencing. Thermally stable polymerase chain reaction assays vastly simplified transportation and storage. Assay preparation and analysis required less than 2 hours. C1 [McAvin, James C.; Swanson, Katherine I.; Chan, Adeline S. T.; Coleman, Russell E.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [McAvin, James C.] Brooks City Base, Mol Epidemiol, San Antonio, TX 78235 USA. [McAvin, James C.] USAF, Expeditionary Med Support Hosp 407, Tallil Air Base, Iraq. [Quintana, Miguel] USA, Ctr Hlth Promot & Prevent Med W, Ft Lewis, WA 98433 USA. [Coleman, Russell E.] USA, Theater Army Med Lab 520, Tallil Air Base, Iraq. RP McAvin, JC (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. FU U.S. Military Infectious Disease Research, Fort Detrick, Maryland; USAF Force Protection Battle Lab, Lackland AFB, San Antonio, Texas FX We wish to thank Ioana Brasov and Derek Smith for assistance provided in parasite culture and nucleic acid extract preparation. This work was funded in part by the U.S. Military Infectious Disease Research Program, Fort Detrick, Maryland, and by the USAF Force Protection Battle Lab, Lackland AFB, San Antonio, Texas. NR 22 TC 3 Z9 3 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 460 EP 466 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300020 PM 22594139 ER PT J AU Rowland, M Plackett, TP Smith, R AF Rowland, Michael Plackett, Timothy P. Smith, Richard TI Yellow Fever Vaccine-Associated Viscerotropic Disease SO MILITARY MEDICINE LA English DT Article ID ADVERSE EVENTS; 17D; IMMUNIZATION; TRIAL AB Yellow fever is a mosquito-transmitted hemorrhagic viral disease that is endemic to tropical regions in South America and Africa. It remains a significant health concern for deploying military personnel, accordingly vaccination is frequently performed on troops. Although the vaccine is generally administered with only minor complications, rare severe complications are also reported. Herein, we report a mild case of yellow fever vaccine-associated viscerotropic disease 4 days after administration of the vaccine. The various complications of the vaccine and their pathogenesis are also reviewed. C1 [Rowland, Michael; Smith, Richard] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Plackett, Timothy P.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC 28310 USA. RP Rowland, M (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. NR 16 TC 5 Z9 5 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 467 EP 469 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300021 PM 22594140 ER PT J AU Keyser, EA Reed, BG Gonzalez-Brown, V Fausett, MB Staat, BC Leath, CA AF Keyser, Erin A. Reed, Beverly G. Gonzalez-Brown, Veronica Fausett, M. Bardett Staat, Barton C. Leath, Charles A. TI Peripartum Cardiomyopathy and Acute Fatty Liver of Pregnancy: One Patient With Two Zebras SO MILITARY MEDICINE LA English DT Article ID DIAGNOSIS; OUTCOMES AB Objective: Peripartum cardiomyopathy (PPCM) and acute fatty liver of pregnancy (AFLP) are rare complications of pregnancy affecting approximately 1/10,000 pregnancies each. We describe a patient who had biopsy-proven AFLP complicated by PPCM. Methods: Chart review and literature search. Results: The patient is a 22-year-old G5P1213 obese African-American female who presented at 30 weeks gestation with abdominal pain. She had normal blood pressures and mildly elevated liver enzymes. After completion of a 24 hour urine protein collection that was consistent with pre-eclampsia, an induction of labor with uncomplicated vaginal delivery was accomplished. Following delivery, a computed tomography scan of the abdomen revealed significant cardiomegaly. An echocardiogram revealed global dysfunction with an ejection fraction of 10%. Liver biopsy showed AFLP. Attempts to establish a unifying etiology were unrevealing. The PPCM was treated with diuretics and intravenous immunoglobulin. The patient's clinical status deteriorated, eventually requiring continuous dialysis, intubation, pharmacologic and mechanical inotropic support, and a feeding tube. The patient was discharged to a long-term care facility where she subsequently passed away from multiorgan failure. Conclusion: AFLP and PPCM are rare complications of pregnancy. We present a patient who had both. Both diseases carry a high mortality rate, and together, are likely fatal. C1 [Keyser, Erin A.; Gonzalez-Brown, Veronica; Fausett, M. Bardett; Staat, Barton C.] Wilford Hall USAF Med Ctr, Dept OB GYN, Lackland AFB, TX 78236 USA. [Reed, Beverly G.] Langley Hosp, Dept OB GYN, Jb Langley Eustis, VA 23665 USA. [Leath, Charles A.] Brooke Army Med Ctr, Dept OB GYN, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. RP Keyser, EA (reprint author), Wilford Hall USAF Med Ctr, Dept OB GYN, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. OI Leath III, Charles/0000-0002-4034-6845 NR 15 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 2012 VL 177 IS 4 BP 470 EP 473 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 921BF UT WOS:000302452300022 PM 22594141 ER PT J AU Morrow, B Stewart, IJ Im, E Tilley, M Aden, J Renz, EM Chung, KK AF Morrow, Benjamin Stewart, Ian J. Im, Ellen Tilley, Molly Aden, James Renz, Evan M. Chung, Kevin K. TI FLUID OVERLOAD AND SURVIVAL IN ADULT BURN PATIENTS: A RETROSPECTIVE ANALYSIS SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of the National-Kidney-Foundation CY MAY 09-13, 2012 CL Washington, DC SP Natl Kidney Fdn C1 [Morrow, Benjamin; Stewart, Ian J.; Im, Ellen; Tilley, Molly] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Aden, James; Renz, Evan M.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2012 VL 59 IS 4 MA 176 BP A58 EP A58 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 916QE UT WOS:000302117500178 ER PT J AU Stewart, I Wickham, J Tilley, M Aden, J Renz, EM Chung, KK AF Stewart, Ian Wickham, Jesse Tilley, Molly Aden, James Renz, Evan M. Chung, Kevin K. TI COMPARISON OF METHODS FOR ESTIMATING BASELINE CREATININE FOR RIFLE CLASSIFICATION IN BURNED COMBAT CASUALTIES SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Meeting Abstract CT Spring Clinical Meeting of the National-Kidney-Foundation CY MAY 09-13, 2012 CL Washington, DC SP Natl Kidney Fdn C1 [Stewart, Ian; Wickham, Jesse; Tilley, Molly] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Aden, James; Renz, Evan M.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD APR PY 2012 VL 59 IS 4 MA 267 BP A81 EP A81 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA 916QE UT WOS:000302117500269 ER PT J AU Zhang, BG Li, YJ Liu, R Pritchett, TM Azenkeng, A Ugrinov, A Haley, JE Li, ZJ Hoffmann, MR Sun, WF AF Zhang, Bingguang Li, Yunjing Liu, Rui Pritchett, Timothy M. Azenkeng, Alexander Ugrinov, Angel Haley, Joy E. Li, Zhongjing Hoffmann, Mark R. Sun, Wenfang TI Synthesis, Structural Characterization, Photophysics, and Broadband Nonlinear Absorption of a Platinum(II) Complex with the 6-(7-Benzothiazol-2'-yl-9,9-diethyl-9?H-fluoren-2-yl)-2,2'-bipyridinyl Ligand SO CHEMISTRY-A EUROPEAN JOURNAL LA English DT Article DE luminescence; nonlinear optics; photophysics; platinum; two-photon absorption ID EXCITED-STATE ABSORPTION; DENSITY-FUNCTIONAL THEORY; EFFECTIVE CORE POTENTIALS; MOLECULAR PHOTOCHEMICAL DEVICE; PHOTOINDUCED CHARGE SEPARATION; REVERSE SATURABLE ABSORPTION; LIGHT-EMITTING MATERIALS; 2-PHOTON ABSORPTION; BASIS-SET; PHENYLACETYLIDE COMPLEXES AB A platinum complex with the 6-(7-benzothiazol-2'-yl-9,9-diethyl-9H-fluoren-2-yl)-2,2'-bipyridinyl ligand (1) was synthesized and the crystal structure was determined. UV/Vis absorption, emission, and transient difference absorption of 1 were systematically investigated. DFT calculations were carried out on 1 to characterize the electronic ground state and aid in the understanding of the nature of low-lying excited electronic states. Complex 1 exhibits intense structured 1pp* absorption at ?abs<440 nm, and a broad, moderate 1MLCT/1LLCT transition at 440520 nm in CH2Cl2 solution. A structured 3pp*/3MLCT emission at about 590 nm was observed at room temperature and at 77 K. Complex 1 exhibits both singlet and triplet excited-state absorption from 450 nm to 750 nm, which are tentatively attributed to the 1pp* and 3pp* excited states of the 6-(7-benzothiazol-2'-yl-9,9-diethyl-9H-fluoren-2-yl)-2,2'-bipyridine ligand, respectively. Z-scan experiments were conducted by using ns and ps pulses at 532 nm, and ps pulses at a variety of visible and near-IR wavelengths. The experimental data were fitted by a five-level model by using the excited-state parameters obtained from the photophysical study to deduce the effective singlet and triplet excited-state absorption cross sections in the visible spectral region and the effective two-photon absorption cross sections in the near-IR region. Our results demonstrate that 1 possesses large ratios of excited-state absorption cross sections relative to that of the ground-state in the visible spectral region; this results in a remarkable degree of reverse saturable absorption from 1 in CH2Cl2 solution illuminated by ns laser pulses at 532 nm. The two-photon absorption cross sections in the near-IR region for 1 are among the largest values reported for platinum complexes. Therefore, 1 is an excellent, broadband, nonlinear absorbing material that exhibits strong reverse saturable absorption in the visible spectral region and large two-photon-assisted excited-state absorption in the near-IR region. C1 [Zhang, Bingguang; Li, Yunjing; Liu, Rui; Ugrinov, Angel; Li, Zhongjing; Sun, Wenfang] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. [Pritchett, Timothy M.] US Army, Res Lab, AMSRD SE EM, Adelphi, MD 20783 USA. [Azenkeng, Alexander] Univ N Dakota, Energy & Environm Res Ctr, Grand Forks, ND 58202 USA. [Haley, Joy E.] USAF, Mat & Mfg Directorate, Res Lab, Wright Patterson AFB, OH 45433 USA. [Hoffmann, Mark R.] Univ N Dakota, Dept Chem, Grand Forks, ND 58202 USA. RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. EM Wenfang.Sun@ndsu.edu RI Liu, Rui/G-3772-2014; li, zhongjing/H-4945-2014 OI li, zhongjing/0000-0002-0125-9693 FU National Science Foundation [CHE-0449598, CHEM-0946990]; Army Research Laboratory [W911NF-06-2-0032] FX This work is supported by National Science Foundation (CAREER CHE-0449598 and CHEM-0946990) and the Army Research Laboratory (W911NF-06-2-0032). NR 98 TC 19 Z9 19 U1 1 U2 30 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY SN 0947-6539 J9 CHEM-EUR J JI Chem.-Eur. J. PD APR PY 2012 VL 18 IS 15 BP 4593 EP 4606 DI 10.1002/chem.201103095 PG 14 WC Chemistry, Multidisciplinary SC Chemistry GA 917HC UT WOS:000302162500020 PM 22407839 ER PT J AU Adley, MD Frank, AO Danielson, KT AF Adley, Mark D. Frank, Andreas O. Danielson, Kent T. TI The high-rate brittle microplane concrete model: Part I: bounding curves and quasi-static fit to material property data SO COMPUTERS AND CONCRETE LA English DT Article DE constitutive modeling; optimization algorithms; microplane models ID INTEGRATION; ALGORITHM; STRESS; M4 AB This paper discusses a new constitutive model called the high-rate brittle microplane (HRBM) model and also presents the details of a new software package called the Virtual Materials Laboratory (VML). The VML software package was developed to address the challenges of Fitting complex material models such as the HRBM model to material property test data and to study the behavior of those models under a wide variety of stress- and strain-paths. VML employs Continuous Evolutionary Algorithms (CEA) in conjunction with gradient search methods to create automatic fitting algorithms to determine constitutive model parameters. The VML code is used to fit the new HRBM model to a well-characterized conventional strength concrete called WES5000. Finally, the ability of the new HRBM model to provide high-fidelity simulations of material property experiments is demonstrated by comparing HRBM simulations to laboratory material property data. C1 [Adley, Mark D.; Frank, Andreas O.; Danielson, Kent T.] USA, Engineer Res & Dev Ctr, Impact & Explos Effects Branch, Vicksburg, MS 39180 USA. RP Adley, MD (reprint author), USA, Engineer Res & Dev Ctr, Impact & Explos Effects Branch, ATTN CEERD-GM-I 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mark.d.adley@usace.army.mil NR 20 TC 9 Z9 9 U1 0 U2 3 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2012 VL 9 IS 4 BP 293 EP 310 PG 18 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 915AS UT WOS:000301995900004 ER PT J AU Frank, AO Adley, MD Danielson, KT McDevitt, HS AF Frank, Andreas O. Adley, Mark D. Danielson, Kent T. McDevitt, Henry S., Jr. TI The high-rate brittle microplane concrete model: Part II: application to projectile perforation of concrete slabs SO COMPUTERS AND CONCRETE LA English DT Article DE numerical modeling; strain-rate dependence; microplane models ID M4 AB In this paper, we examine the behavior of the High-Rate Brittle Microplane (HRBM) concrete model based on a series of penetration experiments. These experiments were conducted with three different slab thicknesses (127, 216 and 254 mm) that provided a significant challenge for the numerical simulations. The 127 mm slab provided little resistance, the 216 mm slab provided nominal resistance and the 254 mm slab approached the perforation limit thickness of the projectile. These experiments provide a good baseline for evaluating material models since they have been shown to be extremely challenging; in fact, we have not encountered many material models that can provide quantitatively predictive results in terms of both projectile exit velocity and material damage. In a companion paper, we described the HRBM material model and its fit to various quasi-static material property data for WES-5000 concrete. In this paper, we show that, when adequately fit to these quasi-static data, the HRBM model does not have significant predictive capabilities, even though the quasi-static material fit may be exceptional. This was attributed to the rate-dependent response of the material. After various rate effects were introduced into the HRBM model, the quantitative predictive nature of the calculations dramatically increased. Unfortunately, not much rate-dependent material property data are in the literature; hence, accurate incorporation of rate effects into material models is difficult. Nonetheless, it seems that rate effects may be critical in obtaining an accurate response for concrete during projectile perforation events. C1 [Frank, Andreas O.; Adley, Mark D.; Danielson, Kent T.; McDevitt, Henry S., Jr.] USA, Engineer Res & Dev Ctr, Impact & Explos Effects Branch, Vicksburg, MS 39180 USA. RP Adley, MD (reprint author), USA, Engineer Res & Dev Ctr, Impact & Explos Effects Branch, ATTN CEERD-GM-I 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM mark.d.adley@usace.army.mil NR 20 TC 6 Z9 6 U1 0 U2 5 PU TECHNO-PRESS PI DAEJEON PA PO BOX 33, YUSEONG, DAEJEON 305-600, SOUTH KOREA SN 1598-8198 J9 COMPUT CONCRETE JI Comput. Concr. PD APR PY 2012 VL 9 IS 4 BP 311 EP 325 PG 15 WC Computer Science, Interdisciplinary Applications; Construction & Building Technology; Engineering, Civil; Materials Science, Characterization & Testing SC Computer Science; Construction & Building Technology; Engineering; Materials Science GA 915AS UT WOS:000301995900005 ER PT J AU Gibbons, RV Streitz, M Babina, T Fried, JR AF Gibbons, Robert V. Streitz, Matthew Babina, Tatyana Fried, Jessica R. TI Dengue and US Military Operations from the Spanish-American War through Today SO EMERGING INFECTIOUS DISEASES LA English DT Article ID ISTHMIAN CANAL ZONE; UNKNOWN ORIGIN; VIETNAM; FEVERS; EPIDEMIC; THAILAND AB Dengue is a major cause of illness among travelers and a threat to military troops operating in areas to which it is endemic. Before and during World War II, dengue frequently occurred in US military personnel in Asia and the South Pacific. From the 1960s into the 1990s, dengue often occurred in US troops in Vietnam, the Philippines, Somalia, and Haiti. We found attack rates as high as 80% and periods of convalescence up to 3-1/2 weeks beyond the acute illness. The increase in dengue throughout the world suggests that it will remain a problem for military personnel until an effective vaccine is licensed. C1 [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Streitz, Matthew; Babina, Tatyana] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Fried, Jessica R.] Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand. RP Gibbons, RV (reprint author), USAMC AFRIMS, Dept Virol, Armed Forces Res Inst Med Sci, APO, AP 96546 USA. EM robert.gibbons@afrims.org NR 40 TC 14 Z9 15 U1 0 U2 5 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD APR PY 2012 VL 18 IS 4 BP 623 EP 630 DI 10.3201/eid1804.110134 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 919MJ UT WOS:000302331600011 PM 22469290 ER PT J AU Hatten, J Zabowski, D Ogden, A Theis, W Choi, B AF Hatten, Jeff Zabowski, Darlene Ogden, Amanda Theis, Walt Choi, Byoungkoo TI Role of season and interval of prescribed burning on ponderosa pine growth in relation to soil inorganic N and P and moisture SO FOREST ECOLOGY AND MANAGEMENT LA English DT Article DE Pinus ponderosa; Prescribed burning; Fire severity; Forest soil; Soil moisture; Nitrogen ID ORGANIC-MATTER; EASTERN OREGON; FIRE; FORESTS; NITROGEN; WILDFIRE; STANDS; TEMPERATURE; MOUNTAINS; MORTALITY AB Fire exclusion over the past 100 years has changed the vegetative community and led to an increase in the propensity for large catastrophic wildfires of ponderosa pine forests. Prescribed burning is used to reduce fuel loads and achieve desired stand conditions while the impact caused by this restoration process is primarily dependent on the severity of the fire, which is managed by burning in either fall or spring. The objectives of this study were to assess the effect of season and interval of burn on soil and tree productivity in a ponderosa pine forest in Malheur National Forest of the southern Blue Mountains of eastern Oregon. Prescribed burning was initiated in the spring of 1997 and fall of 1997 at 5- and 15-year intervals. This study was initiated in 2004 so that the 5-year interval plots had burned twice with 12 years of recovery while the 15-year interval plots had burned only once with 6-7 years of recovery since the last fire. Soils were sampled by major genetic horizon and A horizon samples were analyzed for soil available nitrogen (KCl extractable NF4+ and NO3-) and phosphorous (Bray 1 extract). Soil temperature (2 cm) and moisture (7.5, 25, 50, and 100 cm) were monitored for 24 months. Observations and previous studies indicated that fall burns were more severe than spring burns consuming more fuel and leading to higher rates of tree mortality. Extractable NH4+ and phosphate increased with multiple burns relative to the single burn treatments, but were statistically similar to the control. Soil temperatures were found to be highest in the more severe fall burn treatments, particularly the 5-year interval burns. Soil moisture was also slightly higher with the 5-year interval burns, possibly due to reduced transpiration from understory vegetation and/or reduced interception by the 0 horizon. These changes to the soil did not significantly affect ponderosa pine growth relative to the control and may have caused a slight increase in tree growth with the spring burns applied at a 5-year interval relative to the other burn treatments. We hypothesize that low severity spring burning improved the soil growing environment without injuring trees. Combined with results from previous studies spring burns appear to preserve stand productivity, soil carbon and nitrogen, and understory vegetative communities. However, more research is necessary to examine the long-term consequences of repeated burning in these forest types. Published by Elsevier B.V. C1 [Hatten, Jeff; Choi, Byoungkoo] Mississippi State Univ, Dept Forestry, Mississippi State, MS 39762 USA. [Zabowski, Darlene] Univ Washington, Coll Forest Resources, Seattle, WA 98195 USA. [Ogden, Amanda] USA, Corps Engineers, Seattle, WA 98124 USA. [Theis, Walt] US Forest Serv, USDA, Pacific NW Res Stn, Forestry Sci Lab, Corvallis, OR 97331 USA. RP Hatten, J (reprint author), Mississippi State Univ, Dept Forestry, Mail Stop 9681, Mississippi State, MS 39762 USA. EM jhatten@cfr.msstate.edu RI Hatten, Jeff/E-7742-2010 OI Hatten, Jeff/0000-0002-1685-6351 FU Joint Fire Science Program under Project JFSP [04-2-1-85] FX We acknowledge funding from the Joint Fire Science Program under Project JFSP 04-2-1-85. This is Forest and Wildlife Research Center Contribution number FO417. The authors would also like to thank the Malheur National Forest and the Emigrant Creek Ranger District for their support in the planning and execution of this study. We also thank Eric Turnblom for statistical consulting; Garrett Liles, Brian Strahm, and Pat Hatten for field assistance and Dongsen Xue for laboratory assistance. NR 43 TC 4 Z9 4 U1 2 U2 40 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD APR 1 PY 2012 VL 269 BP 106 EP 115 DI 10.1016/j.foreco.2011.12.036 PG 10 WC Forestry SC Forestry GA 912NQ UT WOS:000301807300013 ER PT J AU Avey, JB Luthans, F Hannah, ST Sweetman, D Peterson, C AF Avey, James B. Luthans, Fred Hannah, Sean T. Sweetman, David Peterson, Christopher TI Impact of employees' character strengths of wisdom on stress and creative performance SO HUMAN RESOURCE MANAGEMENT JOURNAL LA English DT Article ID POSITIVE ORGANIZATIONAL-BEHAVIOR; TEAM PERFORMANCE; GOAL ORIENTATION; DECISION-MAKING; SELF-EFFICACY; WORK; EXPERIENCE; TASK; ENVIRONMENT; PSYCHOLOGY AB Both conventional understanding and positive psychology recognise an important link between people's character strengths and how they perform their jobs. However, no research to date has focused on the relationship of employees' wisdom strengths, potential mediating effects and creative task performance. Utilising a large heterogeneous sample (N = 974) of working adults, this study found that participants' levels of the character strengths of wisdom were positively related to their performance on a creative task and negatively related to their reported level of stress. In addition, stress was found to be negatively related to creative task performance, with reported stress partly mediating the relationship between participants' wisdom and their performance on the creative task. Implications for incorporating character strengths in the development of HRM theory and practice conclude the article. C1 [Avey, James B.] Cent Washington Univ, Coll Business, Dept Management, Ellensburg, WA 98926 USA. [Luthans, Fred; Sweetman, David] Univ Nebraska, Dept Management, Coll Business Adm, Lincoln, NE 68583 USA. [Hannah, Sean T.] US Mil Acad, Army Ctr Excellence Profess Mil Eth, West Point, NY USA. [Peterson, Christopher] Univ Michigan Ann Arbor, Dept Psychol, Ann Arbor, MI USA. RP Avey, JB (reprint author), Cent Washington Univ, Coll Business, Dept Management, 400 E Univ Way, Ellensburg, WA 98926 USA. EM aveyj@cwu.edu NR 59 TC 9 Z9 9 U1 4 U2 38 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0954-5395 J9 HUM RESOUR MANAG J JI Hum. Resour. Manag. J. PD APR PY 2012 VL 22 IS 2 BP 165 EP 181 DI 10.1111/j.1748-8583.2010.00157.x PG 17 WC Industrial Relations & Labor; Management SC Business & Economics GA 918BR UT WOS:000302224400004 ER PT J AU Gada, S Haymore, B McCoy, L Kosisky, S Nelson, M AF Gada, Satyen Haymore, Bret McCoy, Lorne Kosisky, Susan Nelson, Michael TI Frequency of mold and pollen mixing in allergen immunotherapy prescriptions within a large health care system, 1990-2010 SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter ID STABILITY; COCKROACH; EXTRACTS C1 [Gada, Satyen] Natl Naval Med Ctr, Dept Allergy Immunol, Bethesda, MD USA. [Haymore, Bret; McCoy, Lorne; Kosisky, Susan; Nelson, Michael] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. RP Gada, S (reprint author), Natl Naval Med Ctr, Dept Allergy Immunol, Bethesda, MD USA. EM satyen.gada@med.navy.mil OI Gada, Satyen/0000-0003-3539-5543 NR 9 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD APR PY 2012 VL 129 IS 4 BP 1151 EP 1153 DI 10.1016/j.jaci.2011.10.027 PG 6 WC Allergy; Immunology SC Allergy; Immunology GA 917AP UT WOS:000302144600035 PM 22154380 ER PT J AU Petrikovics, I Yu, JCC Thompson, DE Jayanna, P Logue, BA Nasr, J Bhandari, RK Baskin, SI Rockwood, G AF Petrikovics, Ilona Yu, Jorn C. C. Thompson, David E. Jayanna, Prashanth Logue, Brian A. Nasr, Jessica Bhandari, Raj K. Baskin, Steven I. Rockwood, Gary TI Plasma persistence of 2-aminothiazoline-4-carboxylic acid in rat system determined by liquid chromatography tandem mass spectrometry SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Diagnostic biomarker; Forensic biomarker; Cyanide exposure; 2-Aminothiazoline-4-carboxylic acid (ATCA); LC-MS/MS ID CYANIDE EXPOSURE; URINE AB 2-Aminothiazoline-4-carboxylic acid (ATCA) was intravenously injected to rats in order to investigate its plasma distribution. ATCA was extracted from plasma samples by solid phase extraction (SPE) and molecularly imprinted polymer stir bar sorption extraction (MIP-SBSE). Detection and quantification of ATCA were achieved by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). It was found that the intravenously injected ATCA concentration quickly decreased to half within 2.5 h in the rat system. However, after 2.5 h, the concentration of ATCA in plasma stayed constant at least 5 folds above the endogenous ATCA level for more then 48 h. This finding can be used for evaluating ATCA's diagnostic and forensic value as a biomarker for cyanide exposure. (C) 2012 Elsevier B.V. All rights reserved. C1 [Petrikovics, Ilona; Thompson, David E.; Jayanna, Prashanth; Nasr, Jessica] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Yu, Jorn C. C.] Sam Houston State Univ, Coll Criminal Justice, Forens Sci Program, Huntsville, TX 77341 USA. [Logue, Brian A.; Bhandari, Raj K.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Baskin, Steven I.; Rockwood, Gary] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Petrikovics, I (reprint author), Sam Houston State Univ Huntsville, POB 2117,1003 Bowers Blvd, Huntsville, TX 77341 USA. EM ixp004@shsu.edu RI Thompson, David/J-7612-2015; OI Yu, Jorn Chi-Chung/0000-0002-4899-7909 FU National Institutes Of Health Office of the Director; National Institute of Allergy and Infectious Diseases [Y1-OD-0690-01/A-120-B.P2010-01]; USAMRICD under the US Army Research Office of Scientific Services [TCN 08284]; Robert A. Welch Foundation at Sam Houston State University, Huntsville, TX [x-0011]; Sam Houston State University FX The research was supported by the CounterACT Program, National Institutes Of Health Office of the Director, and the National Institute of Allergy and Infectious Diseases, Inter Agency Agreement Number Y1-OD-0690-01/A-120-B.P2010-01, and the USAMRICD under the auspices of the US Army Research Office of Scientific Services Program administered by Battelle (Delivery order 0557, Contract No TCN 08284), and the Robert A. Welch Foundation (x-0011) at Sam Houston State University, Huntsville, TX. Research supports form the Faculty Enhancement Grants for Research (EGR) from Sam Houston State University was greatly appreciated. The authors are thankful for the technical assistances of Galina Kuzmitcheva, Sarah Martin, Phong Ngo and Kelsie Bryand. NR 21 TC 9 Z9 10 U1 1 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD APR 1 PY 2012 VL 891 BP 81 EP 84 DI 10.1016/j.jchromb.2012.01.024 PG 4 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 922YO UT WOS:000302585100012 PM 22386362 ER PT J AU Westrick, RB Diebal, AR Gerber, JP AF Westrick, Richard B. Diebal, Angela R. Gerber, J. Parry TI Dorsal Triquetrum Fracture SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Westrick, Richard B.] Keller Army Community Hosp, West Point, NY USA. [Diebal, Angela R.] Ft Belvoir Community Hosp, Ft Belvoir, VA USA. [Gerber, J. Parry] Baylor Univ Postprofess Sports Med, Phys Therapy Doctoral Residency, USA, West Point, NY USA. RP Westrick, RB (reprint author), Keller Army Community Hosp, West Point, NY USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 2012 VL 42 IS 4 BP 380 EP 380 DI 10.2519/jospt.2012.0407 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 918SR UT WOS:000302271900013 PM 22466108 ER PT J AU Jones, MT Ambegaonkar, JP Nindl, BC Smith, JA Headley, SA AF Jones, Margaret T. Ambegaonkar, Jatin P. Nindl, Bradley C. Smith, Jeffrey A. Headley, Samuel A. TI EFFECTS OF UNILATERAL AND BILATERAL LOWER-BODY HEAVY RESISTANCE EXERCISE ON MUSCLE ACTIVITY AND TESTOSTERONE RESPONSES SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE back squat; sEMG; pitcher squat; 10RM; anabolic hormone ID SQUAT EXERCISE; LEG EXTENSION; THIGH MUSCLES; STANCE WIDTH; EMG ACTIVITY; BACK SQUAT; STRENGTH; MEN; PERFORMANCE; WOMEN AB Jones, MT, Ambegaonkar, JP, Nindl, BC, Smith, JA, and Headley, SA. Effects of unilateral and bilateral lower-body heavy resistance exercise on muscle activity and testosterone responses. J Strength Cond Res 26(4): 1094-1100, 2012-Unilateral and bilateral lower-body heavy resistance exercises (HREs) are used for strength training. Little research has examined whether muscle activation and testosterone (TES) responses differ between these exercises. Our purpose was to compare the effects of unilateral and bilateral lower-body HRE on muscle activity using surface electromyography (sEMG) and TES concentrations. Ten resistance-trained, college-aged male athletes (football, track and field) completed 5 testing sessions in which bilateral (back squat [BS]) and unilateral (pitcher squat [PS]) exercises were performed using a counterbalanced design. Sessions 1 and 2 determined estimated maximum strength (10 repetition maximum [10RM]) in the BS and PS. During testing session 3, muscle activation (sEMG) was measured in the right vastus lateralis, biceps femoris, gluteus maximus, and erector spinae (ES) during both BS and PS (stance leg) exercises. In sessions 4 and 5, total TES concentrations (nanomoles per liter) were measured via blood draws at baseline (preexercise), 0, 5, 10, 15, and 30 minutes postexercise after 4 sets of 10 repetitions at the 10RM. Separate repeated-measures analyses of variance examined differences in sEMG and TES between BS and PS (p < 0.05). The sEMG amplitudes were similar (p = 0.80) for BS (0.22 +/- 0.06 mV) and PS (0.20 +/- 0.07 mV). The TES responses were also similar (p = 0.15) between BS (21.8 +/- 6.9 nmol.L-1) and PS (26.2 +/- 10.1 nmol.L-1). The similar lower limb and back sEMG and TES responses may indicate that the neuromuscular and hormonal demands were comparable for both the BS and PS exercises despite the absolute work being less in the PS. The PS exercise may be an effective method for including unilateral exercise into lower-body resistance training when designing training programs for ground-based activities. C1 [Jones, Margaret T.; Ambegaonkar, Jatin P.] George Mason Univ, Div Hlth & Human Performance, Sport Med Assessment Res & Testing SMART Lab, Fairfax, VA 22030 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Smith, Jeffrey A.; Headley, Samuel A.] Springfield Coll, Dept Exercise Sci & Sport Studies, Springfield, MA USA. RP Jones, MT (reprint author), George Mason Univ, Div Hlth & Human Performance, Sport Med Assessment Res & Testing SMART Lab, Fairfax, VA 22030 USA. EM mjones15@gmu.edu OI Ambegaonkar, Jatin/0000-0002-3790-915X NR 32 TC 6 Z9 6 U1 1 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD APR PY 2012 VL 26 IS 4 BP 1094 EP 1100 DI 10.1519/JSC.0b013e318248ab3b PG 7 WC Sport Sciences SC Sport Sciences GA 916RK UT WOS:000302120700029 PM 22222320 ER PT J AU Stojadinovic, A Zeiger, M AF Stojadinovic, Alexander Zeiger, Martha TI Forward for translation research seminars SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Editorial Material C1 [Stojadinovic, Alexander] Walter Reed Natl Mil Med Ctr, Gen Surg Serv, Bethesda, MD 20889 USA. [Zeiger, Martha] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Stojadinovic, A (reprint author), Walter Reed Natl Mil Med Ctr, Gen Surg Serv, Room 1272,8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Alexander.stojadinovic@med.navy.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR PY 2012 VL 105 IS 5 SI SI BP 437 EP 437 DI 10.1002/jso.23041 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 914EA UT WOS:000301930700001 PM 22441893 ER PT J AU Clive, KS Tyler, JA Clifton, GT Holmes, JP Ponniah, S Peoples, GE Mittendorf, EA AF Clive, Kevin S. Tyler, Josh A. Clifton, G. Travis Holmes, Jarrod P. Ponniah, Sathibalan Peoples, George E. Mittendorf, Elizabeth A. TI The GP2 peptide: A HER2/neu-based breast cancer vaccine SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Review DE HER2; neu; GP2; vaccine; immunotherapy; cancer ID CYTOTOXIC T-LYMPHOCYTES; PULSED DENDRITIC CELLS; OVARIAN-CANCER; HER2/NEU-DERIVED PEPTIDE; CLINICAL-TRIAL; TUMOR-CELLS; HER-2/NEU; MELANOMA; ANTIGENS; TRASTUZUMAB AB Preclinical studies suggest that GP2, a HER2/neu-derived peptide, is immunogenic. Subsequent phase I clinical trials demonstrated that GP2-based vaccines are safe and effective in stimulating peptide-specific immunity. A GP2 peptide vaccine is currently being evaluated in a phase II efficacy trial enrolling breast cancer patients. This article reviews initial studies characterizing GP2, clinical trials investigating GP2-based vaccines, and novel immunotherapy strategies incorporating GP2 in combination with other peptides or with the monoclonal antibody trastuzumab. J. Surg. Oncol. 2012; 105:452458. (c) 2012 Wiley Periodicals, Inc. C1 [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Clive, Kevin S.; Tyler, Josh A.; Clifton, G. Travis; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Holmes, Jarrod P.] USN, Dept Med, Div Hematol & Med Oncol, Med Ctr, San Diego, CA 92152 USA. [Ponniah, Sathibalan; Peoples, George E.] Univ Hlth Sci, Canc Vaccine Dev Lab & Uniformed Serv, Bethesda, MD USA. [Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Mittendorf, EA (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. EM eamitten@mdanderson.org NR 34 TC 18 Z9 18 U1 0 U2 13 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR PY 2012 VL 105 IS 5 SI SI BP 452 EP 458 DI 10.1002/jso.21723 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 914EA UT WOS:000301930700004 PM 22441896 ER PT J AU Mullenix, PS Huddleston, SJ Stojadinovic, A Trachiotis, GD Alexander, EP AF Mullenix, Philip S. Huddleston, Steven J. Stojadinovic, Alexander Trachiotis, Gregory D. Alexander, Edmund P. TI A new heart: Somatic stem cells and myocardial regeneration SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Review DE myocardial infarction; somatic stem cells; heart failure; myocardial regeneration ID COLONY-STIMULATING FACTOR; RANDOMIZED CONTROLLED-TRIAL; FRONT-INTEGRATED REVASCULARIZATION; FACTOR FIRSTLINE-AMI; PROGENITOR CELLS; DOUBLE-BLIND; TRANSCORONARY TRANSPLANTATION; INTRACORONARY TRANSPLANTATION; CLINICAL-TRIAL; INFARCTION AB End-stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource-intensive and limited by organ availability. Bone marrow-derived and cardiac-specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research. J. Surg. Oncol. 2012; 105:475480. (c) 2012 Wiley Periodicals, Inc. C1 [Mullenix, Philip S.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Cardiothorac Surg, Washington, DC 20307 USA. [Mullenix, Philip S.; Trachiotis, Gregory D.; Alexander, Edmund P.] Vet Affairs Med Ctr, Dept Surg, Washington, DC 20422 USA. [Huddleston, Steven J.] Johns Hopkins Univ, Med Ctr, Baltimore, MD 21218 USA. [Trachiotis, Gregory D.] George Washington Univ, Med Ctr, Dept Surg, Washington, DC 20037 USA. RP Mullenix, PS (reprint author), Walter Reed Army Med Ctr, Dept Surg, Div Cardiothorac Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM philip.mullenix@va.gov NR 44 TC 3 Z9 5 U1 1 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR PY 2012 VL 105 IS 5 SI SI BP 475 EP 480 DI 10.1002/jso.23014 PG 6 WC Oncology; Surgery SC Oncology; Surgery GA 914EA UT WOS:000301930700007 PM 22441899 ER PT J AU Lowery, WJ Leath, CA Robinson, RD AF Lowery, William J. Leath, Charles A. Robinson, Randal D. TI Robotic surgery applications in the management of gynecologic malignancies SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Review DE gynecologic cancer; robotic surgery; laparoscopy; surgical techniques ID INVASIVE CERVICAL-CANCER; VAGINAL CUFF DEHISCENCE; RADICAL HYSTERECTOMY; PELVIC LYMPHADENECTOMY; ENDOMETRIAL CANCER; LAPAROSCOPIC HYSTERECTOMY; SURGICAL ROBOTICS; CARCINOMA; TRACHELECTOMY; FERTILITY AB This review evaluates the use of robotic-assisted laparoscopic surgery in the treatment of gynecologic malignancies and objectively evaluates the use of these systems in performing radical hysterectomies and surgical staging of gynecologic malignancies. The review focuses on surgical length, blood loss, complications, recovery time, and adequacy of surgical staging of robotic-assisted surgery compared to abdominal and non-robotically assisted laparoscopic surgery for malignancies. C1 [Robinson, Randal D.] Univ Texas Hlth Sci Ctr San Antonio, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, San Antonio Mil Med Ctr, San Antonio, TX 78229 USA. [Lowery, William J.; Leath, Charles A.] San Antonio Mil Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, San Antonio, TX USA. [Lowery, William J.; Leath, Charles A.; Robinson, Randal D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Lowery, William J.; Leath, Charles A.; Robinson, Randal D.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. RP Robinson, RD (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, San Antonio Mil Med Ctr, 7703 Floyd Curl Dr,MSC 7836, San Antonio, TX 78229 USA. EM robinsonr3@uthscsa.edu OI Leath III, Charles/0000-0002-4034-6845 NR 57 TC 11 Z9 12 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR PY 2012 VL 105 IS 5 SI SI BP 481 EP 487 DI 10.1002/jso.22080 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 914EA UT WOS:000301930700008 PM 22441900 ER PT J AU Maani, CV Shah, MA Hansen, JJ Fowler, M Maani, EV Mcghee, LL AF Maani, Christopher V. Shah, Mohammad A. Hansen, Jacob J. Fowler, Marcie Maani, Elizabeth V. Mcghee, Laura L. TI Translational advances in pain and anesthesia for cancer patients SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Review DE translational advances; pain; anesthesia; outcomes ID SINGLE-NUCLEOTIDE POLYMORPHISM; UNRESECTABLE PANCREATIC-CANCER; POSTTRAUMATIC-STRESS-DISORDER; CHANNEL ALPHA-SUBUNIT; CELIAC PLEXUS BLOCK; RECEPTOR GENE; BREAST-CANCER; RADICAL PROSTATECTOMY; ANALGESIC EFFICACY; RECURRENCE AB Effective cancer pain management requires multidisciplinary approaches for multimodal analgesia. Although opioids have been the cornerstone, developments such as regional anesthesia and interventional pain techniques, complementary and alternative medicine, and new pharmaceuticals also have shown promise to relieve cancer pain. This overview of relevant clinical efforts and the modern day state of the science will afford a better understanding of pain mechanisms and multimodal approaches beneficial in optimizing analgesia for cancer patients. J. Surg. Oncol. 2012; 105:488493. (c) 2012 Wiley Periodicals, Inc. C1 [Maani, Christopher V.; Hansen, Jacob J.] USA, Inst Surg Res, Dept Anesthesia, Ft Sam Houston, TX 78234 USA. [Maani, Christopher V.; Hansen, Jacob J.; Fowler, Marcie; Mcghee, Laura L.] USA, Inst Surg Res, Pain Res Task Area, Ft Sam Houston, TX 78234 USA. [Maani, Christopher V.] Uniformed Serv Univ Hlth Sci, Dept Anesthesia, Bethesda, MD 20814 USA. [Maani, Christopher V.; Shah, Mohammad A.; Hansen, Jacob J.] Brooke Army Med Ctr, Dept Anesthesia, Ft Sam Houston, TX 78234 USA. [Maani, Elizabeth V.] Baylor Coll Med, Dept Radiat Oncol, Houston, TX 77030 USA. [Maani, Elizabeth V.] UT Hlth Sci Ctr, San Antonio, TX USA. RP Maani, CV (reprint author), USA, Inst Surg Res, Dept Anesthesia, Ft Sam Houston, TX 78234 USA. EM christopher.maani@us.army.mil FU United States Army Institute of Surgical Research FX Grant sponsor: United States Army Institute of Surgical Research. NR 68 TC 2 Z9 2 U1 2 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR PY 2012 VL 105 IS 5 SI SI BP 488 EP 493 DI 10.1002/jso.21853 PG 6 WC Oncology; Surgery SC Oncology; Surgery GA 914EA UT WOS:000301930700009 PM 22441901 ER PT J AU Turabi, A Plunkett, AR AF Turabi, Ali Plunkett, Anthony R. TI The application of genomic and molecular data in the treatment of chronic cancer pain SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Review DE cancer pain; translational medicine; gene therapy ID RANDOMIZED CONTROLLED-TRIAL; METHYLTRANSFERASE COMT GENE; NECROSIS-FACTOR-ALPHA; SUBSTANCE P-SAPORIN; NEUROPATHIC PAIN; DOUBLE-BLIND; BREAST-CANCER; INTRATHECAL ZICONOTIDE; DORSAL-HORN; SPINAL-CORD AB Many cancer patients will develop complex pain syndromes requiring aggressive, innovative, and comprehensive multimodal pain management strategies. Recently, data from both animal studies and clinical trials have allowed clinical research to focus on creating applicable clinical treatment strategies. This article is a review of genomic and molecular data, which has contributed to creating novel modalities for use in clinical pain management of patients with cancer-induced pain. J. Surg. Oncol. 2012; 105:494501. (c) 2012 Wiley Periodicals, Inc. C1 [Turabi, Ali; Plunkett, Anthony R.] Walter Reed Army Med Ctr, Def & Vet Pain Management Initiat, Anesthesia & Operat Serv, Washington, DC 20307 USA. RP Plunkett, AR (reprint author), Walter Reed Army Med Ctr, Army Reg Anaesthesia & Pain Management Initiat, Bldg 2,Ward 44,Room 4418, Washington, DC 20307 USA. EM anthony.plunkett@amedd.army.mil NR 100 TC 7 Z9 9 U1 1 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD APR PY 2012 VL 105 IS 5 SI SI BP 494 EP 501 DI 10.1002/jso.21707 PG 8 WC Oncology; Surgery SC Oncology; Surgery GA 914EA UT WOS:000301930700010 PM 22441902 ER PT J AU Dongare, AM LaMattina, B Irving, DL Rajendran, AM Zikry, MA Brenner, DW AF Dongare, Avinash M. LaMattina, Bruce Irving, Douglas L. Rajendran, Arunachalam M. Zikry, Mohammed A. Brenner, Donald W. TI An angular-dependent embedded atom method (A-EAM) interatomic potential to model thermodynamic and mechanical behavior of Al/Si composite materials SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; TOTAL-ENERGY CALCULATIONS; SOLID-LIQUID INTERFACE; SI ALLOY PARTICLES; WAVE BASIS-SET; SILICON; METALS; ALUMINUM; NANOCOMPOSITES; TRANSITION AB A new interatomic potential is developed for the Al/Si system in the formulation of the recently developed angular-dependent embedded atom method (A-EAM). The A-EAM is formulated by combining the embedded atom method potential for Al with the Stillinger-Weber potential for Si. The parameters of the Al/Si cross-interactions are fitted to reproduce the structural energetics of Al/Si bulk alloys determined based on the results of density functional theory calculations and the experimentally observed mixing behavior of the AlSi liquid alloy at high temperatures. The ability to investigate the thermodynamic properties of the Al/Si system is demonstrated by computing the binary phase diagram of the Al-Si system as predicted by the A-EAM potential and comparing with that obtained using experiments. The ability to study the mechanical behavior of the Al/Si composite systems is demonstrated by investigating the micromechanisms related to dynamic failure of the Al/Si nanocomposites using MD simulations. C1 [Dongare, Avinash M.; Irving, Douglas L.; Brenner, Donald W.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Dongare, Avinash M.; Zikry, Mohammed A.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [LaMattina, Bruce] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Rajendran, Arunachalam M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. RP Dongare, AM (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Engn Bldg 1,911 Partners Way,Campus Box 7907, Raleigh, NC 27695 USA. EM amdongare@ncsu.edu RI Brenner, Donald/D-1741-2009; Irving, Douglas/A-1247-2010; Dongare, Avinash/A-3470-2009; OI Dongare, Avinash/0000-0003-3189-3588 FU Army Research Office (ARO) through AMDs National Research Council FX The research is supported by the Army Research Office (ARO) through AMDs National Research Council Research Associateship Award. NR 59 TC 6 Z9 6 U1 0 U2 20 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD APR PY 2012 VL 20 IS 3 AR 035007 DI 10.1088/0965-0393/20/3/035007 PG 17 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 916RV UT WOS:000302121800007 ER PT J AU Dowben, JS Steele, D Froelich, KD Vance, DE Keltner, NL AF Dowben, Jonathan S. Steele, Debbie Froelich, Kimberly D. Vance, David E. Keltner, Norman L. TI Biological Perspectives: Remember the Thyroid SO PERSPECTIVES IN PSYCHIATRIC CARE LA English DT Article DE Hypothyroidism; hyperthyroidism; thyroid dysfunction C1 [Vance, David E.; Keltner, Norman L.] Univ Alabama, Sch Nursing, Birmingham, AL 35294 USA. [Dowben, Jonathan S.] Brooke Army Med Ctr, Pediat & Adolescent Behav Hlth Serv, Ft Sam Houston, TX 78234 USA. [Steele, Debbie] Calif State Univ Fresno, Dept Nursing, Fresno, CA 93740 USA. [Froelich, Kimberly D.] Birmingham Vet Med Ctr, Birmingham, AL USA. RP Keltner, NL (reprint author), Univ Alabama, Sch Nursing, Birmingham, AL 35294 USA. EM nkeltner@uab.edu OI Vance, David/0000-0002-0498-6263 NR 10 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-5990 J9 PERSPECT PSYCHIATR C JI Perspect. Psychiatr. Care PD APR PY 2012 VL 48 IS 2 BP 65 EP 69 DI 10.1111/j.1744-6163.2012.00329.x PG 5 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 915XG UT WOS:000302060300002 PM 22458720 ER PT J AU Haile, MA Ifju, PG AF Haile, M. A. Ifju, P. G. TI Application of Elastic Image Registration and Refraction Correction for Non-Contact Underwater Strain Measurement SO STRAIN LA English DT Article DE image reconstruction; image registration; local weighted mean transform ID CAMERA CALIBRATION; COMPUTER VISION; STEREO VISION; METHODOLOGY; OBJECTS; LIGHT AB The refraction-induced image distortion introduces large errors in the deformation measurement of fluid submerged specimens using digital image correlation (DIC). This study provides a review of the nature of the refraction-induced image distortion, assesses experimental conditions that interact with refraction and proposes an elastic image registration technique to correct the refraction distortion of underwater images. In the elastic image registration technique, control points are selected on reference and refracted images of a template object and locally sensitive transformation functions that overlay the two images are obtained. The transformation functions so obtained are then used to reconstruct undistorted images from underwater images and the former are used as input to a DIC system. The proposed approach has shown to improve the refraction error in the order of 58% for typical material test samples undergoing deformation inside a water-filled glass chamber. C1 [Haile, M. A.] USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ifju, P. G.] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. RP Haile, MA (reprint author), USA, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 21 TC 3 Z9 3 U1 1 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0039-2103 J9 STRAIN JI Strain PD APR PY 2012 VL 48 IS 2 BP 136 EP 142 DI 10.1111/j.1475-1305.2011.00805.x PG 7 WC Materials Science, Characterization & Testing SC Materials Science GA 912EJ UT WOS:000301777200004 ER PT J AU Keefer, ML Taylor, GA Garletts, DF Helms, CK Gauthier, GA Pierce, TM Caudill, CC AF Keefer, Matthew L. Taylor, Gregory A. Garletts, Douglas F. Helms, Chad K. Gauthier, Greg A. Pierce, Todd M. Caudill, Christopher C. TI Reservoir entrapment and dam passage mortality of juvenile Chinook salmon in the Middle Fork Willamette River SO ECOLOGY OF FRESHWATER FISH LA English DT Article DE high-head dam; Oncorhynchus; reservoir entrapment; residualism; turbine mortality ID LIFE-HISTORY TYPES; LOWER GRANITE DAM; SNAKE RIVER; DELAYED MORTALITY; COLUMBIA RIVER; PACIFIC SALMON; SURVIVAL; OREGON; GROWTH; MIGRATION AB High-head dams in Oregons Willamette River basin inhibit seaward migration and present significant mortality risks to ESA-listed juvenile Chinook salmon (Oncorhynchus tshawytscha). Over 7 years, we passively collected 13,365 downstream-migrating juvenile salmon in rivers above and below Willamette dams. Most salmon emigrated from upstream sites in FebruaryJune, but passed dams in NovemberFebruary when reservoirs were drawn down near annual lows, and access to deep-water passage routes improved. Samples collected above reservoirs were dominated by subyearlings, whereas below-dam samples were a phenotypically diverse mix of subyearling, yearling and older salmon. The life history data indicated that Willamette reservoirs seasonally entrap many salmon and some sea-ready smolts probably residualise. Annual dam-passage mortality estimates were 859% (mean = 26%). Individual salmon mortality risk increased significantly with body length and varied with reservoir elevation and discharge. Operational changes that allow timely volitional emigration and development of less hazardous passage routes would benefit this threatened population. C1 [Keefer, Matthew L.; Caudill, Christopher C.] Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA. [Taylor, Gregory A.; Garletts, Douglas F.; Helms, Chad K.; Gauthier, Greg A.; Pierce, Todd M.] USA, Corps Engineers, Lowell, OR 97452 USA. RP Keefer, ML (reprint author), Univ Idaho, Dept Fish & Wildlife Resources, Moscow, ID 83844 USA. EM mkeefer@uidaho.edu RI Caudill, Christopher/M-7906-2014 FU U.S. Army Corps of Engineers FX This project was funded by the U.S. Army Corps of Engineers and many people contributed to the work. We thank C. Murphy and C. Lewellen (USACE) for field help and project coordination; D. Griffith (USACE) for coordination; the staff at the Willamette Hatchery (ODFW) for providing hatchery salmon used in trap efficiency tests; the General Maintenance and Powerhourse Staff at the Willamette Valley Project (USACE); the South Willamette Watershed district staff (ODFW); the Willamette National Forest staff (USFS); and the NMFS and ODFW staff that facilitated permitting. NR 50 TC 12 Z9 12 U1 1 U2 40 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0906-6691 EI 1600-0633 J9 ECOL FRESHW FISH JI Ecol. Freshw. Fish PD APR PY 2012 VL 21 IS 2 BP 222 EP 234 DI 10.1111/j.1600-0633.2011.00540.x PG 13 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA 905OP UT WOS:000301282400008 ER PT J AU Li, Y Cao, XY Zhu, DQ Chappell, MA Miller, LF Mao, JD AF Li, Yuan Cao, Xiaoyan Zhu, Dongqiang Chappell, Mark A. Miller, Lesley F. Mao, Jingdong TI Characterization of coals and their laboratory-prepared black carbon using advanced solid-state C-13 nuclear magnetic resonance spectroscopy SO FUEL PROCESSING TECHNOLOGY LA English DT Article DE Lignite; Humic acid; Anthracite; Black carbon; Solid-state NMR ID TURKISH BEYPAZARI LIGNITE; NATURAL ORGANIC-MATTER; AIR OXIDATION; HUMIC SUBSTANCES; LOW-TEMPERATURE; STRUCTURAL CHARACTERISTICS; NMR-SPECTROSCOPY; ACTIVATED CARBON; BITUMINOUS COAL; QUANTIFICATION AB Lignite, anthracite, humic acid fraction of lignite, and their laboratory-prepared black carbon (BC) were characterized in detail by advanced solid state C-13 NMR spectroscopy to examine how the differences in chemical structures of fuels (lignite and anthracite) would affect the structures of their BC. Anthracite was almost completely dominated by aromatics (96.9%), with very minor CCH3. Although lignite contained mostly aromatics (76.1%), significant aliphatics (21.3%) as well as small amounts of COO/N-C=O and O-alkyls were also present. In addition, anthracite had more aromatic C-C groups than lignite. Their BC samples both exhibited increased oxygenated functional groups such as COO, aromatic C-O and O-alkyl groups, and concomitant decrease of aromatic C-H and nonpolar alkyls. The H-1-C-13 recoupled long-range dipolar dephasing experiments indicated the growth of aromatic cluster sizes in BC. Although the aromaticity of anthracite was much larger than those of lignite and lignite humic acid, their aromatic cluster sizes were quite similar. The BC samples had much larger aromatic cluster sizes than anthracite despite their smaller aromaticities. Therefore, higher rank or higher aromaticity may not imply larger aromatic cluster size in coal. The structures of two BC samples were similar despite the contrasting structural differences of their original coals. (C) 2011 Elsevier B.V. All rights reserved. C1 [Li, Yuan; Cao, Xiaoyan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Zhu, Dongqiang] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Jiangsu 210093, Peoples R China. [Zhu, Dongqiang] Nanjing Univ, Sch Environm, Jiangsu 210093, Peoples R China. [Chappell, Mark A.; Miller, Lesley F.] USA, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, 4541 Hampton Blvd, Norfolk, VA 23529 USA. EM jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [CBET-0853950] FX We thank the National Science Foundation (CBET-0853950) for the support of this research. NR 55 TC 5 Z9 6 U1 1 U2 49 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3820 J9 FUEL PROCESS TECHNOL JI Fuel Process. Technol. PD APR PY 2012 VL 96 BP 56 EP 64 DI 10.1016/j.fuproc.2011.12.014 PG 9 WC Chemistry, Applied; Energy & Fuels; Engineering, Chemical SC Chemistry; Energy & Fuels; Engineering GA 911BI UT WOS:000301691900008 ER PT J AU Chen, JYC Barnes, MJ AF Chen, Jessie Y. C. Barnes, Michael J. TI Supervisory Control of Multiple Robots: Effects of Imperfect Automation and Individual Differences SO HUMAN FACTORS LA English DT Article DE human-robot interaction; supervisory control; intelligent agent; military; imperfect automation; individual differences; spatial ability; attentional control; gaming experience ID SIMULATED MULTITASKING ENVIRONMENT; HUMAN-PERFORMANCE ISSUES; WORKING-MEMORY CAPACITY; USER-INTERFACE DESIGN; CONCURRENT PERFORMANCE; TASKS; MILITARY; TELEOPERATION; PREDICTORS; ATTENTION AB Objective: A military multitasking environment was simulated to examine the effects of an intelligent agent, RoboLeader, on the performance of robotics operators. Background: The participants' task was to manage a team of ground robots with the assistance of RoboLeader, an intelligent agent capable of coordinating the robots and changing their routes on the basis of battlefield developments. Method: In the first experiment, RoboLeader was perfectly reliable; in the second experiment, RoboLeader's recommendations were manipulated to be either false-alarm prone or miss prone, with a reliability level of either 60% or 90%. The visual density of the targeting environment was manipulated by the presence or absence of friendly soldiers. Results: RoboLeader, when perfectly reliable, was helpful in reducing the overall mission times. The type of RoboLeader imperfection (false-alarm vs. miss prone) affected operators' performance of tasks involving visual scanning (target detection, route editing, and situation awareness). There was a consistent effect of visual density (clutter of the visual scene) for multiple performance measures. Participants' attentional control and video gaming experience affected their overall multitasking performance. In both experiments, participants with greater spatial ability consistently outperformed their low-spatial-ability counterparts in tasks that required effective visual scanning. Conclusion: Intelligent agents, such as RoboLeader, can benefit the overall human-robot teaming performance. However, the effects of type of agent unreliability, tasking requirements, and individual differences have complex effects on human-agent interaction. Application: The current results will facilitate the implementation of robots in military settings and will provide useful data to designs of systems for multirobot control. C1 [Chen, Jessie Y. C.] USA, Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. RP Chen, JYC (reprint author), USA, Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. EM jessie.chen@us.army.mil FU U.S. Army Research Laboratory's Director's Research Initiative program; SOURCE Army Technology Objective FX This research was supported by U.S. Army Research Laboratory's Director's Research Initiative program and SOURCE Army Technology Objective. The authors wish to thank Zhihua Qu, Mark Snyder, Caitlin Kenny, Daniel Barber, David Adams, and Michelle Harper-Sciarini for their contribution to this project. NR 58 TC 21 Z9 21 U1 5 U2 24 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD APR PY 2012 VL 54 IS 2 BP 157 EP 174 DI 10.1177/0018720811435843 PG 18 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 915FJ UT WOS:000302009200001 PM 22624284 ER PT J AU Mathias, DK Plieskatt, JL Armistead, JS Bethony, JM Abdul-Majid, KB McMillan, A Angov, E Aryee, MJ Zhan, B Gillespie, P Keegan, B Jariwala, AR Rezende, W Bottazzi, ME Scorpio, DG Hotez, PJ Dinglasan, RR AF Mathias, D. K. Plieskatt, J. L. Armistead, J. S. Bethony, J. M. Abdul-Majid, K. B. McMillan, A. Angov, E. Aryee, M. J. Zhan, B. Gillespie, P. Keegan, B. Jariwala, A. R. Rezende, W. Bottazzi, M. E. Scorpio, D. G. Hotez, P. J. Dinglasan, R. R. TI Expression, Immunogenicity, Histopathology, and Potency of a Mosquito-Based Malaria Transmission-Blocking Recombinant Vaccine SO INFECTION AND IMMUNITY LA English DT Article ID PLASMODIUM-FALCIPARUM; AMINOPEPTIDASE-N; SAFETY; TRIAL; CHILDREN; INFANTS; CD13 AB Vaccines have been at the forefront of global research efforts to combat malaria, yet despite several vaccine candidates, this goal has yet to be realized. A potentially effective approach to disrupting the spread of malaria is the use of transmission-blocking vaccines (TBV), which prevent the development of malarial parasites within their mosquito vector, thereby abrogating the cascade of secondary infections in humans. Since malaria is transmitted to human hosts by the bite of an obligate insect vector, mosquito species in the genus Anopheles, targeting mosquito midgut antigens that serve as ligands for Plasmodium parasites represents a promising approach to breaking the transmission cycle. The midgut-specific anopheline alanyl aminopeptidase N (AnAPN1) is highly conserved across Anopheles vectors and is a putative ligand for Plasmodium ookinete invasion. We have developed a scalable, high-yield Escherichia coli expression and purification platform for the recombinant AnAPN1 TBV antigen and report on its marked vaccine potency and immunogenicity, its capacity for eliciting transmission-blocking antibodies, and its apparent lack of immunization-associated histopathologies in a small-animal model. C1 [Mathias, D. K.; Armistead, J. S.; Abdul-Majid, K. B.; McMillan, A.; Dinglasan, R. R.] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA. [Mathias, D. K.; Armistead, J. S.; Abdul-Majid, K. B.; McMillan, A.; Dinglasan, R. R.] Malaria Res Inst, Baltimore, MD USA. [Plieskatt, J. L.; Bethony, J. M.; Jariwala, A. R.] George Washington Univ, Med Ctr, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA. [Plieskatt, J. L.; Zhan, B.; Gillespie, P.; Keegan, B.; Rezende, W.; Bottazzi, M. E.; Hotez, P. J.] Baylor Coll Med, Sabin Vaccine Inst, Houston, TX 77030 USA. [Plieskatt, J. L.; Zhan, B.; Gillespie, P.; Keegan, B.; Rezende, W.; Bottazzi, M. E.; Hotez, P. J.] Texas Childrens Hosp, Baylor Coll Med, Ctr Vaccine Dev, Houston, TX 77030 USA. [Scorpio, D. G.] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA. [Angov, E.] Walter Reed Army Inst Res, US Mil Malaria Res Program, Silver Spring, MD USA. [Aryee, M. J.] Johns Hopkins Univ, Sch Med, Dept Oncol, Div Biostat & Bioinformat, Baltimore, MD 21205 USA. RP Dinglasan, RR (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA. EM rdinglas@jhsph.edu RI Scorpio, Diana/C-4839-2012; OI Dinglasan, Rhoel/0000-0001-5433-8179; Dinglasan, Rhoel/0000-0001-6563-1506; Hotez, Peter/0000-0001-8770-1042 FU PATH-Malaria Vaccine Initiative; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH) [1K22AI077707]; Bloomberg Family Foundation; Johns Hopkins Malaria Research Institute (JHMRI) FX This work was funded in part by the PATH-Malaria Vaccine Initiative, the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH) (grant 1K22AI077707), the Bloomberg Family Foundation and the Johns Hopkins Malaria Research Institute (JHMRI) (to R.R.D.), a JHMRI Predoctoral Fellowship (to J.S.A.), and the Calvin A. and Helen L. Lang Postdoctoral Fellowship (to D.K.M.). This publication was also made possible by the NIH National Center for Research Resources (grant number UL1 RR 025005). NR 30 TC 18 Z9 19 U1 3 U2 13 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 2012 VL 80 IS 4 BP 1606 EP 1614 DI 10.1128/IAI.06212-11 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 914EL UT WOS:000301931900032 PM 22311924 ER PT J AU Hu, GL Chen, CQ Ramesh, KT McCauley, JW AF Hu, Guangli Chen, C. Q. Ramesh, K. T. McCauley, J. W. TI Dynamic multiaxial response of a hot-pressed aluminum nitride SO SCRIPTA MATERIALIA LA English DT Article DE Compression test; Ceramics; Strain rate; Fracture; Confining stress ID COMPRESSIVE FAILURE; BRITTLE SOLIDS; UNIAXIAL COMPRESSION; MECHANICAL-BEHAVIOR; LATERAL CONFINEMENT; CERAMICS; FRACTURE; CARBIDE; IMPACT; MODEL AB The dynamic multiaxial response of hot-pressed AIN is characterized through quasi-static uniaxial compression, dynamic uniaxial compression and dynamic confined compression experiments within the strain rate range of 10(-3)-10(3) s(-1). Real-time visualization shows the failure patterns change from axial splitting under uniaxial dynamic compression to shear faulting under confinement. The compressive strength is moderately sensitive to both the confining stress and the loading rate. Post-mortem fracture surface studies show that the dominant fracture mechanism remains transgranular fracture under all loading conditions. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Hu, Guangli; Chen, C. Q.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [McCauley, J. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21078 USA. RP Hu, GL (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM ghu6@jhu.edu RI Hu, Guangli/F-2461-2011; Chen, Changqiang/G-6310-2010 OI Hu, Guangli/0000-0003-4751-1628; FU Center for Advanced Metallic and Ceramic Systems at the Johns Hopkins University; Army Research Laboratory under the REDCOM-ACQ-CTR [W911NF-06-2-0006] FX This work was performed under the auspices of the Center for Advanced Metallic and Ceramic Systems at the Johns Hopkins University, supported by the Army Research Laboratory under the REDCOM-ACQ-CTR Cooperative Agreement No. W911NF-06-2-0006. NR 39 TC 8 Z9 8 U1 0 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD APR PY 2012 VL 66 IS 8 BP 527 EP 530 DI 10.1016/j.scriptamat.2011.12.037 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 912QY UT WOS:000301815900007 ER PT J AU Smith, R Demmy, TL AF Smith, Richard Demmy, Todd L. TI Pulmonary Metastasectomy for Soft Tissue Sarcoma SO SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Article DE Soft tissue sarcoma; Pulmonary metastases; Metastasectomy; Sarcomatous metastases; Pulmonary resection ID POSITRON-EMISSION-TOMOGRAPHY; ASSISTED THORACIC-SURGERY; COMPUTER-AIDED DETECTION; LONG-TERM SURVIVAL; LUNG METASTASES; THORACOSCOPIC RESECTION; MUSCULOSKELETAL SARCOMAS; SURGICAL RESECTION; PROGNOSTIC-FACTORS; MEDIAN STERNOTOMY AB The American Cancer Society predicts 10,520 new cases and 3920 deaths from soft tissue sarcoma (STS) for 2010. STS disseminates primarily via the hematogenous route, although lymphatic spread does occur with certain subtypes. The lung is the most common metastatic site in most large series, accounting for up to 80% of metastases. The median overall survival for pulmonary metastatic disease with current multidisciplinary treatment is approximately 12 to 14 months. Pulmonary metastasectomy (PM) represents the only potentially curative treatment for patients with STS and lung metastases. This article discusses the management of STS using PM. C1 [Demmy, Todd L.] Roswell Pk Canc Inst, Dept Thorac Surg, Buffalo, NY 14263 USA. [Smith, Richard] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Smith, Richard] Canc Res Ctr Hawaii, Dept Surg, Honolulu, HI 96813 USA. [Demmy, Todd L.] SUNY Buffalo, Dept Surg, Buffalo, NY 14203 USA. RP Demmy, TL (reprint author), Roswell Pk Canc Inst, Dept Thorac Surg, Elm & Carlton St, Buffalo, NY 14263 USA. EM Todd.Demmy@roswellpark.org NR 111 TC 11 Z9 11 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1055-3207 J9 SURG ONCOL CLIN N AM JI Surg. Oncol. Clin. N. Am. PD APR PY 2012 VL 21 IS 2 BP 269 EP + DI 10.1016/j.soc.2011.12.001 PG 19 WC Oncology; Surgery SC Oncology; Surgery GA 915NG UT WOS:000302033700008 PM 22365519 ER PT J AU Pizarro, JM Chang, WE Bah, MJ Wright, LKM Saviolakis, GA Alagappan, A Robison, CL Shah, JD Meyerhoff, JL Cerasoli, DM Midboe, EG Lumley, LA AF Pizarro, Jose M. Chang, Wenling E. Bah, Mariama J. Wright, Linnzi K. M. Saviolakis, George A. Alagappan, Arun Robison, Christopher L. Shah, Jinesh D. Meyerhoff, James L. Cerasoli, Douglas M. Midboe, Eric G. Lumley, Lucille A. TI Repeated Exposure to Sublethal Doses of the Organophosphorus Compound VX Activates BDNF Expression in Mouse Brain SO TOXICOLOGICAL SCIENCES LA English DT Article DE neurotrophins; BDNF; organophosphorus compounds; chemical warfare nerve agents; VX; mice ID GULF-WAR VETERANS; NEUROTROPHIC FACTOR; MESSENGER-RNA; TRANSCRIPTIONAL RESPONSES; ALZHEIMERS-DISEASE; SPATIAL MEMORY; DENTATE GYRUS; AGENT-VX; RAT; HIPPOCAMPUS AB The highly toxic organophosphorus compound VX [O-ethyl S-[2-(diisopropylamino)ethyl]methylphosphonate] is an irreversible inhibitor of the enzyme acetylcholinesterase (AChE). Prolonged inhibition of AChE increases endogenous levels of acetylcholine and is toxic at nerve synapses and neuromuscular junctions. We hypothesized that repeated exposure to sublethal doses of VX would affect genes associated with cell survival, neuronal plasticity, and neuronal remodeling, including brain-derived neurotrophic factor (BDNF). We examined the time course of BDNF expression in C57BL/6 mouse brain following repeated exposure (1/day x 5 days/week x 2 weeks) to sublethal doses of VX (0.2 LD50 and 0.4 LD50). BDNF messenger RNA expression was significantly (p < 0.05) elevated in multiple brain regions, including the dentate gyrus, CA3, and CA1 regions of the hippocampal formation, as well as the piriform cortex, hypothalamus, amygdala, and thalamus, 72 h after the last 0.4 LD50 VX exposure. BDNF protein expression, however, was only increased in the CA3 region of the hippocampus. Whether increased BDNF in response to sublethal doses of VX exposure is an adaptive response to prevent cellular damage or a precursor to impending brain damage remains to be determined. If elevated BDNF is an adaptive response, exogenous BDNF may be a potential therapeutic target to reduce the toxic effects of nerve agent exposure. C1 [Pizarro, Jose M.; Wright, Linnzi K. M.; Robison, Christopher L.; Cerasoli, Douglas M.; Midboe, Eric G.; Lumley, Lucille A.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Pizarro, Jose M.; Chang, Wenling E.; Bah, Mariama J.; Saviolakis, George A.; Alagappan, Arun; Robison, Christopher L.; Shah, Jinesh D.; Meyerhoff, James L.; Lumley, Lucille A.] Walter Reed Army Inst Res, Div Neurosci, Silver Spring, MD 20910 USA. [Chang, Wenling E.] Mitre Corp, Dept Biotechnol, San Diego, CA 92106 USA. RP Lumley, LA (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM lucille.a.lange@us.army.mil OI Robison, Christopher/0000-0001-8693-6149 FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (PIs: Lucille Lumley and Tsung-Ming Shih). NR 41 TC 2 Z9 2 U1 0 U2 7 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD APR PY 2012 VL 126 IS 2 BP 497 EP 505 DI 10.1093/toxsci/kfr353 PG 9 WC Toxicology SC Toxicology GA 915FD UT WOS:000302008600020 PM 22240983 ER PT J AU Kent, M Upp, J Spevak, C Shannon, C Buckenmaier, C AF Kent, Michael Upp, Justin Spevak, Christopher Shannon, Clarence Buckenmaier, Chester TI Ultrasound-Guided Peripheral Nerve Stimulator Placement in Two Soldiers with Acute Battlefield Neuropathic Pain SO ANESTHESIA AND ANALGESIA LA English DT Article ID OPERATIONS ENDURING FREEDOM; PERCUTANEOUS PLACEMENT; IRAQI FREEDOM; FEASIBILITY; ELECTRODES; EXTREMITY; INJURIES; SURGERY; LESIONS; SYSTEM AB Acute peripheral neuropathic pain after combat-related polytrauma is a common occurrence in the United States military that is often refractory to current drugs and regional anesthesia. Both spinal cord and peripheral nerve stimulation are successfully used for chronic neuropathic pain states, but are not reported for acute neuropathic pain. We present 2 cases of percutaneous ultrasound-guided sciatic peripheral nerve stimulation placement in soldiers who had conditions precluding them from spinal cord stimulation placement. Opioid reduction and marked increase in functionality were possible in one case, and cessation of opioid escalation, with eventual reduction after permanent implantation, was possible in the other. (Anesth Analg 2012;114:875-8) C1 [Kent, Michael; Upp, Justin; Spevak, Christopher; Shannon, Clarence; Buckenmaier, Chester] Walter Reed Army Med Ctr, Dept Anesthesiol, Rockville, MD 20852 USA. RP Kent, M (reprint author), Walter Reed Army Med Ctr, Dept Anesthesiol, 11300 Rockville Pike,Suite 709, Rockville, MD 20852 USA. EM michael.kent@med.navy.mil FU Defense and Veterans Center for Integrative Pain Management (DVCIPM) FX Supported by the Defense and Veterans Center for Integrative Pain Management (DVCIPM). NR 28 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD APR PY 2012 VL 114 IS 4 BP 875 EP 878 DI 10.1213/ANE.0b013e318247f6b2 PG 4 WC Anesthesiology SC Anesthesiology GA 912UL UT WOS:000301826800025 PM 22344240 ER PT J AU Buckenmaier, CC Capacchione, J Mielke, AR Bina, S Shields, C Kwon, KH McKnight, G Fish, DA Bedocs, P AF Buckenmaier, Chester C., III Capacchione, John Mielke, Arthur R. Bina, Saiid Shields, Cynthia Kwon, Kyung H. McKnight, Geselle Fish, David A. Bedocs, Peter TI The Effect of Lipid Emulsion Infusion on Postmortem Ropivacaine Concentrations in Swine: Endeavoring to Comprehend a Soldier's Death SO ANESTHESIA AND ANALGESIA LA English DT Article ID ANESTHETIC SYSTEMIC TOXICITY; BATTLEFIELD ANESTHESIA; CARDIAC TOXICITY; BUPIVACAINE; LEVOBUPIVACAINE; LIDOCAINE; CARE AB BACKGROUND: Lipid emulsion (20%) is advocated as a rescue drug for local anesthetic toxicity. No study has measured the impact of lipid emulsion therapy on postmortem local anesthetic serum levels. METHODS: We anesthetized Yorkshire swine (n = 11) and standard monitors were placed. The swine received 1.5 mg/kg/min IV ropivacaine until death (asystole). Blood samples were drawn before infusion (baseline) and at 5-minute intervals during the infusion for measurement of blood gases and free, bound, and total serum ropivacaine concentrations via high-performance liquid chromatography. Five swine received ropivacaine only, and 6 swine received ropivacaine plus a single bolus dose of 20% lipid emulsion (1 mg/kg) when the mean arterial blood pressure reached 50 mm Hg. Ropivacaine infusions were terminated at asystole and no resuscitation was initiated. Total ropivacaine dose and time to death were recorded. The swine were cooled (mean temperature, 25.5 degrees C +/- 0.8 degrees C at 6 hours postmortem) to reflect morgue conditions. Serum samples were drawn at asystole, 1, 3, and 6 hours postmortem for analysis. Additionally, a craniotomy and laparotomy were performed at those times to remove 1.5 to 3 g each of brain, lung, liver, kidney, and muscle for analysis. RESULTS: Analysis of the postmortem serum ropivacaine concentrations in the control and the lipid-treated animals indicated that both the total (bound and not bound to proteins) and free (not bound to proteins) ropivacaine concentrations were significantly higher in the lipid-treated animals (P = 0.0094 and P = 0.0063, respectively). Furthermore, time had a significant effect on increasing the postmortem free ropivacaine concentrations (P = 0.0095). The lipid group had a statistically significant earlier onset of death (asystole) compared with the control group (P = 0.0274). Tissue analysis indicated that the ropivacaine concentration significantly decreased postmortem in the lung, kidney, and brain tissues of the lipid-treated animals (P = 0.0168, P = 0.0073, and P = 0.0018, respectively). Tissue drug concentrations in the control animals remained unchanged after death. CONCLUSIONS: Our data show that postmortem blood samples in swine that experience local anesthetic cardiovascular collapse and are treated with lipid emulsions will result in measurements that cannot be directly extrapolated to premortem drug concentrations. (Anesth Analg 2012;114:894-900) C1 [Buckenmaier, Chester C., III; Kwon, Kyung H.; McKnight, Geselle; Fish, David A.; Bedocs, Peter] Def & Vet Pain Management Initiat, Washington, DC USA. [Buckenmaier, Chester C., III; Capacchione, John; Shields, Cynthia] Walter Reed Army Med Ctr, Dept Surg Anesthesia & Operat Serv, Washington, DC 20307 USA. [Buckenmaier, Chester C., III; Capacchione, John; Mielke, Arthur R.; Bina, Saiid; Bedocs, Peter] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, Bethesda, MD 20814 USA. RP Buckenmaier, CC (reprint author), Def & Vet Ctr Integrat Pain Management, 11300 Rockville Pike, Rockville, MD 20852 USA. EM Chester.Buckenmaier@us.army.mil FU John Murtha Neuroscience and Pain Institute, Johnstown, PA FX Supported by institutional funding from the John Murtha Neuroscience and Pain Institute, Johnstown, PA. NR 15 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD APR PY 2012 VL 114 IS 4 BP 894 EP 900 DI 10.1213/ANE.0b013e31822c10b8 PG 7 WC Anesthesiology SC Anesthesiology GA 912UL UT WOS:000301826800028 PM 21865498 ER PT J AU Salinas, J Cancio, LC Chung, KK Mann-Salinas, EA Wade, CE Serio-Melvin, M Wolf, SE AF Salinas, Jose Cancio, Leopoldo C. Chung, Kevin K. Mann-Salinas, Elizabeth A. Wade, Charles E. Serio-Melvin, Maria Wolf, Steven E. TI Computer-assisted decision making in burns fluid resuscitation Reply SO CRITICAL CARE MEDICINE LA English DT Letter C1 [Salinas, Jose; Chung, Kevin K.] USA, Inst Surg Res, Burn Ctr Intens Care Unit, Ft Sam Houston, TX 78234 USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX USA. [Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA. RP Salinas, J (reprint author), USA, Inst Surg Res, Burn Ctr Intens Care Unit, Ft Sam Houston, TX 78234 USA. NR 6 TC 1 Z9 1 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD APR PY 2012 VL 40 IS 4 BP 1396 EP 1397 DI 10.1097/CCM.0b013e31824a5133 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 912QC UT WOS:000301813700085 ER PT J AU Linkov, F Maxwell, GL Felix, AS Lin, Y Lenzner, D Bovbjerg, DH Lokshin, A Hennon, M Jakicic, JM Goodpaster, BH DeLany, JP AF Linkov, Faina Maxwell, G. Larry Felix, Ashley S. Lin, Yan Lenzner, Diana Bovbjerg, Dana H. Lokshin, Anna Hennon, Meredith Jakicic, John M. Goodpaster, Bret H. DeLany, James P. TI Longitudinal evaluation of cancer-associated biomarkers before and after weight loss in RENEW study participants: Implications for cancer risk reduction SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Obesity; Weight loss; Cancer biomarkers; Interleukins; Endometrial cancer ID BODY-MASS-INDEX; ENDOMETRIAL CANCER; BARIATRIC SURGERY; EPIDEMIOLOGIC EVIDENCE; ADIPONECTIN LEVELS; OVARIAN-CANCER; SERUM-LEVELS; OBESITY; WOMEN; MORTALITY AB Introduction. Obesity is a major risk factor for the development of endometrial cancer (EC). An improved understanding of biologic mechanisms associated with weight loss, including alteration in inflammation, hormonal balance, and cancer antigens expression may lead to the development of effective cancer prevention strategies. The goal of this study was to explore longitudinal biomarker changes in obese women who underwent weight loss intervention, testing the hypothesis biomarker levels can be altered through intentional weight loss. Methods. Serum samples from 89 participants with Class II and Class III obesity and 43 non morbidly obese comparisons were obtained in Re-Energize with Nutrition. Exercise and Weight Loss (RENEW) study as previously reported. Twenty-one bead-based xMAP immunoassays were utilized, including cancer-associated antigens, cytokines, chemokines, and hormones. One-way repeated measures ANOVA was used to examine the association between changes in biomarker expression levels over time (baseline, 6 months and 12 months). Linear mixed effects models were used to examine longitudinal relationships between biomarker expression levels. Results. Mean levels of VEGF, soluble E-selectin. GH, adiponectin, IL-6, IL-7, CA-125, and IGFBP-1 significantly differed between time periods. In adjusted mixed linear models, decreasing BMI was significantly associated with lower levels of soluble E-selectin and IL-6 and increases in GH, adiponectin, and IGFBP-1. Conclusions. This is one of the first efforts to explore changes in cancer-associated biomarkers in a cohort of weight loss research participants at high risk for EC development. Our findings demonstrate that changes in the expression of markers can be achieved with weight loss intervention. (C) 2012 Elsevier Inc. All rights reserved. C1 [Linkov, Faina; Lokshin, Anna] Univ Pittsburgh, Magee Womens Hosp, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA. [Linkov, Faina; Hennon, Meredith] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Gynecol Canc Ctr, Washington, DC 20307 USA. [Felix, Ashley S.] NCI, Canc Prevent Fellowship Program, Ctr Canc Training, Rockville, MD USA. [Bovbjerg, Dana H.] Univ Pittsburgh, Inst Canc, Biobehav Med Oncol Program, Pittsburgh, PA USA. [Lin, Yan; Lenzner, Diana] Univ Pittsburgh, Inst Canc, Dept Biostat Facil, Pittsburgh, PA USA. [Jakicic, John M.; Goodpaster, Bret H.; DeLany, James P.] Univ Pittsburgh, Phys Act & Weight Management Res Ctr, Dept Hlth & Phys Act, Pittsburgh, PA USA. RP Linkov, F (reprint author), Magee Womens Res Inst, Dept OBGYN & Reprod Sci, 3380 Blvd Allies,Room 323 Isalys, Pittsburgh, PA 15232 USA. EM Faina.Linkov@gmail.com FU Commonwealth of Pennsylvania Department of Health, Henry M Jackson Foundation, ACS [MRSG-10-079-01-CPPB]; Bodymedia, Inc. FX Research support: Commonwealth of Pennsylvania Department of Health, Henry M Jackson Foundation, ACS Mentored Research Award (MRSG-10-079-01-CPPB). Funding sources did not participate in project design and data analysis.; Author John M. Jakicic is a member of the Scientific Advisory Board of Alere Wellbeing (formerly Free 8, Clear). He also receives a Research Funding from Bodymedia, Inc. and a speaking honorarium from Jenny Craig. The rest of the authors declared no conflict of interest. NR 46 TC 9 Z9 9 U1 0 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD APR PY 2012 VL 125 IS 1 BP 114 EP 119 DI 10.1016/j.ygyno.2011.12.439 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 913LO UT WOS:000301879600021 PM 22198242 ER PT J AU Simprini, LA Villines, TC Rich, M Taylor, AJ AF Simprini, Lauren A. Villines, Todd C. Rich, Michael Taylor, Allen J. TI The relationship between subclinical atherosclerosis, non-high-density lipoprotein cholesterol, exercise, and diet among male participants of the PACC Project SO JOURNAL OF CLINICAL LIPIDOLOGY LA English DT Article DE Coronary calcium; Non-HDL; Exercise; Diet; Risk factors ID CORONARY-ARTERY CALCIFICATION; COMPUTED-TOMOGRAPHY; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; DISEASE RISK; YOUNG-ADULTS; CALCIUM; MARKERS; QUESTIONNAIRE; METAANALYSIS AB BACKGROUND: Non-high-density lipoprotein (HDL) cholesterol is recommended as a secondary lipid goal treated initially with lifestyle modification. However, the relationship between non-HDL and subclinical atherosclerosis is unknown. We examined the independent relationships between corollary artery calcium (CAC), lipids including non-HDL, exercise, and diet among healthy male participants of the Prospective Army Coronary Calcium (PACC) Project. METHODS: Male participants from the PACC Project (n = 1637, mean age 42.8 years; no history of coronary heart disease) were studied. We used validated surveys to measure dietary quality and habitual physical exercise. Fasting lipid concentrations and other cardiovascular risk variables were measured. Subclinical atherosclerosis was detected with the use of electron beam computed tomography for CAC. Factors independently associated with the presence of any detectable CAC (CAC score > 0), including standard CV risk variables, non-HDL, exercise, and diet, were evaluated with the use of logistic regression. RESULTS: The mean Framingham risk score was 4.6 +/- 2.6%; CAC was present in 22.4%. Fasting lipid concentrations showed mean LDL-C 128 +/- 32 mg/dL, HDL-C 50 +/- 13 mg/dL, TG-C 130 +/- 86 mg/dL, and non-HDL-C 154 +/- 37 mg/dL. Men with CAC had significantly greater levels of LDL-C (135 vs 127 mg/dL), TG (148 vs 124 mg/dL), and non-HDL-C (164 vs 151 mg/dL) and less habitual physical activity (P = 0.006). There were nonsignificant trends between prevalent CAC, greater amounts of dietary fat intake, and lower HDL-C. In successive multivariable logistic regression models for the dependent variable CAC, only non-HDL-C (odds ratio [OR] 1.012 per mg/dL; 95% CI 1.002-1.023; P = .019) and age (OR 1.119 per year; 95% CI 1.063-1.178; P < .001) were independently associated with the presence of CAC, and exercise (OR 0.808; 95% CI 0.703-0.928; P = 0.003) was associated with the absence of CAC. CONCLUSIONS: Non-HDL-C and exercise are independently predictive of the presence of subclinical CAC among healthy lower-risk middle-aged men. (C) 2012 National Lipid Association. All rights reserved. C1 [Simprini, Lauren A.; Taylor, Allen J.] Washington Hosp Ctr, Medstar Hlth Res Inst, Washington, DC 20010 USA. [Simprini, Lauren A.; Taylor, Allen J.] Georgetown Univ, Washington, DC USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Villines, Todd C.] Uniformed Serv Univ Hlth Sci, Washington, DC USA. [Rich, Michael] Georgetown Univ, Washington, DC USA. RP Taylor, AJ (reprint author), Washington Hosp Ctr, Medstar Hlth Res Inst, Washington, DC 20010 USA. EM allen.taylor@medstar.net FU Congressionally-directed, Peer Reviewed Medical Research Program [ERMS 00239017-00216] FX Supported by the Congressionally-directed, Peer Reviewed Medical Research Program, grant number ERMS 00239017-00216. NR 20 TC 6 Z9 8 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1933-2874 J9 J CLIN LIPIDOL JI J. Clin. Lipidol. PD APR PY 2012 VL 6 IS 2 BP 174 EP 179 DI 10.1016/j.jacl.2011.11.005 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 910XU UT WOS:000301682700012 PM 22385551 ER PT J AU Stringer, DB Sheth, PN Allaire, PE AF Stringer, David B. Sheth, Pradip N. Allaire, Paul E. TI Physics-based modeling strategies for diagnostic and prognostic application in aerospace systems SO JOURNAL OF INTELLIGENT MANUFACTURING LA English DT Article DE Condition-based maintenance; Fault detection; Finite element modeling; Frequency error; Vibration analysis ID VIBRATION AB This paper presents physics-based models as a key component of prognostic and diagnostic algorithms of health monitoring systems. While traditionally overlooked in condition-based maintenance strategies, these models potentially offer a robust alternative to experimental or other stochastic modeling data. Such a strategy is particularly useful in aerospace applications, presented in this paper in the context of a helicopter transmission model. A lumped parameter, finite element model of a widely used helicopter transmission is presented as well as methods of fault seeding and detection. Fault detection through diagnostic vibration parameters is illustrated through the simulation of a degraded rolling-element bearing supporting the transmission's input shaft. Detection in the time domain and frequency domain is discussed. The simulation shows such modeling techniques to be useful tools in health monitoring analysis, particularly as sources of information for algorithms to compare with real-time or near real-time sensor data. C1 [Stringer, David B.] NASA Glenn Res Ctr MS23 3, Army Res Lab, Vehicle Technol Directorate, Cleveland, OH 44039 USA. [Sheth, Pradip N.; Allaire, Paul E.] Univ Virginia, Charlottesville, VA 22904 USA. RP Stringer, DB (reprint author), NASA Glenn Res Ctr MS23 3, Army Res Lab, Vehicle Technol Directorate, 21000 Brookpk Rd, Cleveland, OH 44039 USA. EM david.stringer@us.army.mil; pea@virginia.edu RI Stringer, D. Blake/B-3051-2017 OI Stringer, D. Blake/0000-0002-4375-2638 NR 31 TC 3 Z9 4 U1 2 U2 15 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0956-5515 J9 J INTELL MANUF JI J. Intell. Manuf. PD APR PY 2012 VL 23 IS 2 SI SI BP 155 EP 162 DI 10.1007/s10845-009-0340-4 PG 8 WC Computer Science, Artificial Intelligence; Engineering, Manufacturing SC Computer Science; Engineering GA 909YX UT WOS:000301605000001 ER PT J AU Keller, J Carr, D Love, F Grabill, P Ngo, H Shanthakumaran, P AF Keller, Jonathan Carr, Damian Love, Frances Grabill, Paul Hieu Ngo Shanthakumaran, Perumal TI AH-64D main transmission accessory drive spur gear installation fault detections SO JOURNAL OF INTELLIGENT MANUFACTURING LA English DT Article DE Apache; Rotorcraft; Transmission; Clutch; Diagnostic ID DIAGNOSTICS AB The US Army has launched an aggressive program to implement condition based maintenance on its rotary wing assets. Condition Based Maintenance takes advantage of technology developments in the areas of machinery monitoring, signal processing and fault modeling to reduce the cost of ownership through improved maintenance procedures. Documenting the reduction in maintenance burden, cost savings and increased safety through early detection of helicopter faults is an important step in justifying the program. This paper describes a novel technique used to detect a serious fault in the accessory section of the AH-64D Apache main transmission. The technique determines if the primary or secondary clutch system is driving the aircraft accessories through a tachometer speed ratio. The method has identified three aircraft operating on the secondary system allowing Army maintenance crews to replace the affected transmissions and quickly restore the aircraft to operational status. C1 [Keller, Jonathan; Carr, Damian] USA, Res Dev & Engn Command, DIR, USA RDECOM,Attn RDMR AEA, Redstone Arsenal, AL 35898 USA. [Love, Frances] Syst Dynam Int Inc, Redstone Arsenal, AL 35898 USA. [Grabill, Paul] Honeywell Aerosp, Poway, CA 92064 USA. [Hieu Ngo; Shanthakumaran, Perumal] Boeing Co, Mesa, AZ 85215 USA. RP Keller, J (reprint author), USA, Res Dev & Engn Command, DIR, USA RDECOM,Attn RDMR AEA, Bldg 4488, Redstone Arsenal, AL 35898 USA. EM jonathan.a.keller@us.army.mil RI Lin, Zhao/C-8319-2011 OI Lin, Zhao/0000-0002-6131-9723 NR 18 TC 0 Z9 0 U1 0 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0956-5515 J9 J INTELL MANUF JI J. Intell. Manuf. PD APR PY 2012 VL 23 IS 2 SI SI BP 205 EP 211 DI 10.1007/s10845-009-0345-z PG 7 WC Computer Science, Artificial Intelligence; Engineering, Manufacturing SC Computer Science; Engineering GA 909YX UT WOS:000301605000006 ER PT J AU Page, WF Chubb, M Feng, XS Fan, LY Li, YZ Weber, NS Levin, LI Niebuhr, DW AF Page, William F. Chubb, Mikayla Feng, Xiaoshu Fan, Lynn Y. Li, Yuanzhang Weber, Natalya S. Levin, Lynn I. Niebuhr, David W. TI National Estimates of Seroincidence and Seroprevalence for Herpes Simplex Virus Type 1 and Type 2 Among US Military Adults Aged 18 to 29 Years SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID UNITED-STATES; FACTORY-WORKERS; INFECTION; RISK; WOMEN; ACQUISITION; PREVALENCE; INCIDENT; PREGNANCY; INCREASES AB Background: While population-based seroprevalence studies of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are widespread, seroincidence studies are largely limited to select or high-risk populations. The US military offers a potential population to derive national seroincidence rate estimates for young adults (ages 18-29). Methods: We used banked, longitudinal serum specimens collected in a cohort of 1094 military personnel aged 18 to 30 years who served between 1989 and 2005 to estimate national HSV-1 and HSV-2 seroincidence and seroprevalence for the young, adult military population, weighted according to the US Census. Serum was tested with indirect ELISA (enzyme-linked immunosorbent assay). Results: Estimated national seroincidence rates for the US young, adult military population were 9.1 per 100 person-years (95% confidence interval: 4.6-13.5) for HSV-1 and 6.2 (95% confidence interval: 3.1-9.3) for HSV-2. Female sex and black race were associated with significantly higher HSV-2 seroconversion rates. Our estimated HSV1/2 seroprevalences were comparable to US national data provided by National Health and Nutrition Examination Surveys' serosurveys except for non-Hispanic blacks and Hispanics. Conclusion: Although these US 2000 Census-weighted estimates of HSV-1 and HSV-2 seroincidence apply only to young, military adults, they nonetheless supply, to our knowledge, the only national figures that might be used to predict US national HSV1/2 seroincidence in young adults. Thus, we believe that our findings in this military population can be used to inform the planning of HSV-1 and 2 prevention measures in the general, young-adult US population. C1 [Page, William F.; Chubb, Mikayla; Feng, Xiaoshu; Fan, Lynn Y.; Li, Yuanzhang; Weber, Natalya S.; Levin, Lynn I.; Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Page, William F.; Chubb, Mikayla; Feng, Xiaoshu; Fan, Lynn Y.] Allied Technol Grp Inc, Rockville, MD USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM david.niebuhr@us.army.mil OI Li, Yuanzhang/0000-0001-8872-4430 FU Stanley Medical Research Institute; Department of the Army through a Cooperative Research and Development Agreement, Materiel Command [DAMD17-04-001] FX Supported by Stanley Medical Research Institute and Department of the Army through a Cooperative Research and Development Agreement, Materiel Command Control Number DAMD17-04-001. NR 29 TC 8 Z9 9 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD APR PY 2012 VL 39 IS 4 BP 241 EP 250 DI 10.1097/OLQ.0b013e3182401a17 PG 10 WC Infectious Diseases SC Infectious Diseases GA 911UZ UT WOS:000301746400001 PM 22421688 ER PT J AU Del Rose, MS Wagner, CC AF Del Rose, Michael S. Wagner, Christian C. TI Survey on classifying human actions through visual sensors SO ARTIFICIAL INTELLIGENCE REVIEW LA English DT Article DE Visual human action classification; Artificial intelligence; Hidden Markov Model; Grammars ID HIDDEN MARKOV-MODELS; RECOGNIZING HUMAN-BEHAVIOR; HUMAN ACTIVITY RECOGNITION; GESTURE RECOGNITION; VIDEO; CLASSIFICATION; ALGORITHM; HMMS AB The ability to predict the intentions of people based solely on their visual actions is a skill only performed by humans and animals. This requires segmentation of items in the field of view, tracking of moving objects, identifying the importance of each object, determining the current role of each important object individually and in collaboration with other objects, relating these objects into a predefined scenario, assessing the selected scenario with the information retrieve, and finally adjusting the scenario to better fit the data. This is all accomplished with great accuracy in less than a few seconds. The intelligence of current computer algorithms has not reached this level of complexity with the accuracy and time constraints that humans and animals have, but there are several research efforts that are working towards this by identifying new algorithms for solving parts of this problem. This survey paper lists several of these efforts that rely mainly on understanding the image processing and classification of a limited number of actions. It divides the activities up into several groups and ends with a discussion of future needs. C1 [Del Rose, Michael S.] USA, TARDEC, Warren, MI USA. [Wagner, Christian C.] Oakland Univ, Rochester Hills, MI USA. RP Del Rose, MS (reprint author), USA, TARDEC, Warren, MI USA. EM mike.delrose@us.army.mil; wagner@oakland.edu NR 82 TC 4 Z9 4 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0269-2821 EI 1573-7462 J9 ARTIF INTELL REV JI Artif. Intell. Rev. PD APR PY 2012 VL 37 IS 4 BP 301 EP 311 DI 10.1007/s10462-011-9232-z PG 11 WC Computer Science, Artificial Intelligence SC Computer Science GA 909DN UT WOS:000301542600003 ER PT J AU Moser, RD Singh, PM Kahn, LF Kurtis, KE AF Moser, Robert D. Singh, Preet M. Kahn, Lawrence F. Kurtis, Kimberly E. TI Chloride-induced corrosion resistance of high-strength stainless steels in simulated alkaline and carbonated concrete pore solutions SO CORROSION SCIENCE LA English DT Article DE Stainless steel; Concrete; Steel reinforced concrete; Polarization; Pitting corrosion; Alkaline corrosion ID REINFORCING STEEL; SELECTIVE DISSOLUTION; BEHAVIOR; THRESHOLD; GROWTH AB This paper presents the results of a study examining the induced corrosion resistance of austenitic, duplex, and martensitic high-strength stainless steels (HSSSs) and a pearlitic prestressing steel using cyclic potentiodynamic polarization (CPP) techniques in simulated alkaline and carbonated concrete solutions. CPP testing found that in alkaline solutions, all HSSSs showed high corrosion resistance at Cl- concentrations from zero to 0.25 M. When exposed to carbonated solutions, corrosion resistance was reduced and only duplex grades S32205 and S32304 exhibited high corrosion resistance. A strong correlation between microstructural defects (e.g., strain-induced martensite) and corrosion damage was observed in the cold-drawn HSSSs. Published by Elsevier Ltd. C1 [Moser, Robert D.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Attn CEERD GM C, Vicksburg, MS 39180 USA. [Singh, Preet M.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Kahn, Lawrence F.; Kurtis, Kimberly E.] Georgia Inst Technol, Sch Civil & Environm Engn, Atlanta, GA 30332 USA. RP Moser, RD (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Attn CEERD GM C, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM robert.d.moser@usace.army.mil; Preet.Singh@mse.gatech.edu; Lawrence.Kahn@ce.gatech.edu; Kimberly.Kurtis@ce.gatech.edu OI Kurtis, Kimberly/0000-0002-1252-7323 FU Georgia Department of Transportation (GDOT) [07-70]; SMART (Science, Mathematics, and Research for Transformation); Georgia Tech Presidential Fellowship FX The authors thank the Georgia Department of Transportation (GDOT) for sponsoring this research under Project No. 07-70. Additional financial support for this work provided by the SMART (Science, Mathematics, and Research for Transformation) Scholarship Program and the Georgia Tech Presidential Fellowship is gratefully acknowledged. Sumiden Wire Products Corporation and Fagersta Stainless are thanked for their donation of materials, for drawing the HSSS wire, and all technical assistance provided. The authors also thank Daniel Schuetz for assisting with the production of test specimens and metallographic sample preparation and Jamshad Mahmood for help with fabricating experimental setups. The opinions and conclusions expressed herein are those of the authors and do not represent the opinions, conclusions, policies, standards or specifications of the GDOT or of other cooperating organizations. Permission to publish this manuscript was granted by Director, Geotechnical & Structures Laboratory, US Army Engineer Research and Development Center. NR 44 TC 31 Z9 33 U1 6 U2 44 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-938X J9 CORROS SCI JI Corrosion Sci. PD APR PY 2012 VL 57 BP 241 EP 253 DI 10.1016/j.corsci.2011.12.012 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 910GA UT WOS:000301624000029 ER PT J AU Hammerbeck, CD Hooper, JW AF Hammerbeck, Christopher D. Hooper, Jay W. TI T Cells Are Not Required for Pathogenesis in the Syrian Hamster Model of Hantavirus Pulmonary Syndrome (vol 85, pg 9929, 2011) SO JOURNAL OF VIROLOGY LA English DT Correction C1 [Hammerbeck, Christopher D.; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Hammerbeck, CD (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD APR PY 2012 VL 86 IS 7 BP 4043 EP 4043 DI 10.1128/JVI.00203-12 PG 1 WC Virology SC Virology GA 906TV UT WOS:000301371500064 ER PT J AU Whitehouse, CA Kesterson, KE Duncan, DD Eshoo, MW Wolcott, M AF Whitehouse, C. A. Kesterson, K. E. Duncan, D. D. Eshoo, M. W. Wolcott, M. TI Identification and characterization of Francisella species from natural warm springs in Utah, USA SO LETTERS IN APPLIED MICROBIOLOGY LA English DT Article DE detection; ecology; environmental; recreational water; identification; molecular epidemiology ID FORMERLY YERSINIA-PHILOMIRAGIA; CHRONIC-GRANULOMATOUS-DISEASE; IONIZATION-MASS-SPECTROMETRY; MULTIPLE SEQUENCE ALIGNMENT; UNIVERSAL BIOSENSOR; TULARENSIS; PCR; TULAREMIA; BACTEREMIA; STRAINS AB Aims: To characterize Francisella isolated from two natural warm springs in Utah and compare them to a strain isolated from a patient with probable exposure to one of the springs in 2001. Methods and Results: A total of 39 presumptive Francisella isolates were obtained from two springs, Wasatch Hot Spring and Hobo Warm Spring, just north of Salt Lake City, Utah. All isolates were characterized by a combination of biochemical and molecular analyses, including novel PCR/electrospray ionization-mass spectrometry (ESI-MS) typing assays. Thirty-one were identified as F. philomiragia, while the remaining eight were identified as F. tularensis ssp. novicida. Phylogenetic analysis of the 16S rRNA sequences revealed 27 isolates, which clustered with F. philomiragia, albeit into two distinct clades. The remaining isolates clustered along with other F. tularensis strains including the Utah clinical isolate. Testing with the PCR/ESI-MS assays confirmed the identities of the isolates, but both yielded DNA signatures distinct from that of the clinical isolate. Conclusion: We were successful in isolating several Francisella strains from natural warm springs; however, none appeared to genetically match the original 2001 clinical isolate. Significance and Impact of the Study: This work highlights the presence of viable, potentially pathogenic Franscisella species living in the unique environmental niche of natural warm springs. C1 [Whitehouse, C. A.] USA, Ctr Genom Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Kesterson, K. E.] USA, Dugway Proving Ground, UT USA. [Duncan, D. D.; Eshoo, M. W.] Ibis Biosci, Carlsbad, CA USA. RP Whitehouse, CA (reprint author), USA, Ctr Genom Sci, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM chris.whitehouse@us.army.mil FU Joint Program Executive Office for Chemical and Biological Defense (JPEO-CBD); Department of Homeland Security [NBCHC070041] FX We thank David Bedwell, Terry Abshire, Bill Dorman and Jessica Carpenter for their excellent technical assistance during this project. The research described herein was sponsored in part by the Joint Program Executive Office for Chemical and Biological Defense (JPEO-CBD) Critical Reagents Program. Funding for the development of the PCR/ESI-MS Francisella genotyping assay was provided by the Department of Homeland Security contract no. NBCHC070041. NR 41 TC 14 Z9 14 U1 1 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0266-8254 J9 LETT APPL MICROBIOL JI Lett. Appl. Microbiol. PD APR PY 2012 VL 54 IS 4 BP 313 EP 324 DI 10.1111/j.1472-765X.2012.03214.x PG 12 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 905PZ UT WOS:000301286000008 PM 22283482 ER PT J AU Szelenyi, ER Urso, ML AF Szelenyi, Eric R. Urso, Maria L. TI Time-course analysis of injured skeletal muscle suggests a critical involvement of ERK1/2 signaling in the acute inflammatory response SO MUSCLE & NERVE LA English DT Article DE cytokines; hsp; inflammation; mitogen-activated stress pathway; skeletal muscle ID NF-KAPPA-B; HEAT-SHOCK-PROTEIN; TUMOR-NECROSIS-FACTOR; P38 MAP KINASE; RESPIRATORY EPITHELIAL-CELLS; TNF-ALPHA; REPERFUSION INJURY; INDUCED APOPTOSIS; IMMUNE-RESPONSES; REGULATED KINASE AB Introduction: The coupling and timing of pro- and anti-inflammatory processes in skeletal muscle injury is poorly understood. We investigated the temporal response and regulated processes of extracellular signalregulated kinases 1 and 2 (ERK1/2), p38, and IkappaB kinase (IKK) a/beta signaling pathways after traumatic injury. Methods: Traumatic freeze injury was delivered to the tibialis anterior (TA) muscle in C57BL/6J mice, and injured and uninjured TA muscles were analyzed 372 h into the recovery period. Results: Significant increases in pro-inflammatory cytokine transcription accompanied IKK beta phosphorylation, robust ERK pathway activation, and reduced heat shock protein (Hsp) protein expression at 324 h. At 24 h, ERK activation was abolished concomitantly with a significant increase in mitogen-activated protein kinase phosphatase-1 (MKP-1). After 24 h, cytokine transcription along with ERK1/2 and IKK beta phosphorylation remained suppressed, whereas Hsp protein expression rose to significant levels by 72 h and associated with IKK beta. Conclusions: Results indicate a bimodal regulation of ERK1/2 in acute inflammation in which it is supportive from 3 to 24 h, and suppressive from 24 to 72 h. Muscle Nerve, 2012 C1 [Szelenyi, Eric R.; Urso, Maria L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Urso, ML (reprint author), USA, Environm Med Res Inst, 42 Kansas St,Bldg 42, Natick, MA 01760 USA. EM maria.urso@us.army.mil OI Urso, Maria/0000-0001-8906-4673 NR 59 TC 9 Z9 9 U1 1 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0148-639X EI 1097-4598 J9 MUSCLE NERVE JI Muscle Nerve PD APR PY 2012 VL 45 IS 4 BP 552 EP 561 DI 10.1002/mus.22323 PG 10 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 910QV UT WOS:000301657000014 PM 22431089 ER PT J AU Michael, NL AF Michael, Nelson L. TI Immune Correlates of Infection Risk in the Thai Phase III ALVAC-HIV/AIDSVA-B/E Prime Boost Study SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Meeting Abstract CT 13th Annual International Meeting of the Institute of Human Virology CY OCT 30-NOV 03, 2011 CL Baltimore, MD C1 [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1525-4135 EI 1077-9450 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD APR PY 2012 VL 59 SU 1 MA 113 BP 46 EP 46 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA V45YE UT WOS:000209851100024 ER PT J AU Perez, C AF Perez, Celestino, Jr. TI The Soldier as Lethal Warrior and Cooperative Political Agent: On the Soldier's Ethical and Political Obligations toward the Indigenous Other SO ARMED FORCES & SOCIETY LA English DT Article DE nation-building; professional military ethic; counterinsurgency; strategy; Arendt; Connolly AB An adequate configuration of the military ethic, which encompasses the U.S. Army's professional and ethical self-understanding, should integrate the soldier's ethicopolitical obligations toward the indigenous other; that is, the person who lives where soldiers are deployed. The argument first posits a distinction between cosmopolitan and patriotic configurations of the soldier's obligations. David Petraeus's counterinsurgency guidance typifies the former; Matthew Moten's configuration of the professional military ethic typifies the latter. Second, Hannah Arendt's distinction between Work and Action instructs that one does not "build" a polity; political foundations are fugitive and unpredictable. Third, considering Arendt's theory and current missions, the soldier as a political agent cannot produce stability or build a nation with instrumental certitude; however, the soldier can foster conditions and intervene in ways to nudge circumstances toward a better state of affairs. Finally, military professionals should cultivate a cosmopolitan attitude informed by William Connolly's ethos of engagement to help them fulfill their obligations to the other. C1 [Perez, Celestino, Jr.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Perez, C (reprint author), 614 McClellan Ave, Ft Leavenworth, KS 66027 USA. EM perez.celestino@gmail.com NR 43 TC 4 Z9 4 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD APR PY 2012 VL 38 IS 2 BP 177 EP 204 DI 10.1177/0095327X11418322 PG 28 WC Political Science; Sociology SC Government & Law; Sociology GA 901VQ UT WOS:000300996400001 ER PT J AU Meyer, HW Brannon, RM AF Meyer, Hubert W., Jr. Brannon, Rebecca M. TI A model for statistical variation of fracture properties in a continuum mechanics code SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Statistical fracture; Johnson-Cook fracture model; Weibull statistics; Size effect; Behind armor debris AB Continuum mechanics codes modeling failure of materials historically have considered those materials to be homogeneous, with all elements of a material in the computation having the same failure properties. This is, of course, unrealistic but expedient. But as computer hardware and software has evolved, the time has come to investigate a higher level of complexity in the modeling of failure. The Johnson-Cook fracture model is widely used in such codes, so it was chosen as the basis for the current work. The CTH finite difference code is widely used to model ballistic impact and penetration, so it also was chosen for the current work. The model proposed here does not consider individual flaws in a material, but rather varies a material's Johnson-Cook parameters from element to element to achieve inhomogeneity. A Weibull distribution of these parameters is imposed, in such a way as to include a size effect factor in the distribution function. The well-known size effect on the failure of materials must be physically represented in any statistical failure model not only for the representations of bodies in the simulation (e.g., an armor plate), but also for the computational elements, to mitigate element resolution sensitivity of the computations. The statistical failure model was tested in simulations of a Behind Armor Debris (BAD) experiment, and found to do a much better job at predicting the size distribution of fragments than the conventional (homogeneous) failure model. The approach used here to include a size effect in the model proved to be insufficient, and including correlated statistics and/or flaw interactions may improve the model. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Meyer, Hubert W., Jr.] Bowhead Sci & Technol LLC, USARL, Aberdeen Proving Ground, MD 21005 USA. [Brannon, Rebecca M.] Univ Utah, Salt Lake City, UT 84112 USA. RP Meyer, HW (reprint author), Bowhead Sci & Technol LLC, USARL, Aberdeen Proving Ground, MD 21005 USA. EM hubert.meyer@us.army.mil; Rebecca.Brannon@utah.edu FU DoD HPC Center at APG, MD FX This work was supported in part by a grant of high performance computing (HPC) time from the DoD HPC Center at APG, MD. NR 16 TC 13 Z9 13 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD APR PY 2012 VL 42 BP 48 EP 58 DI 10.1016/j.ijimpeng.2010.09.007 PG 11 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 904RR UT WOS:000301216100005 ER PT J AU House, JM AF House, Jonathan M. TI Architect of Soviet Victory in World War II: The Life and Theories of G. S. Isserson SO RUSSIAN REVIEW LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD APR PY 2012 VL 71 IS 2 BP 346 EP 347 PG 2 WC History SC History GA 902OV UT WOS:000301048700036 ER PT J AU Lairet, KF Lairet, JR King, BT Renz, EM Blackbourne, LH AF Lairet, Kimberly F. Lairet, Julio R. King, Booker T. Renz, Evan M. Blackbourne, Lorne H. TI PREHOSPITAL BURN MANAGEMENT IN A COMBAT ZONE SO PREHOSPITAL EMERGENCY CARE LA English DT Article DE burn; prehospital; resuscitation; military; combat ID MILITARY CASUALTIES; FLUID CREEP; RESUSCITATION AB Objective. The purpose of this article is to provide a descriptive study of the management of burns in the prehospital setting of a combat zone. Methods. A retrospective chart review was performed of U. S. casualties with >20% total-body-surface-area thermal burns, transported from the site of injury to Ibn Sina Combat Support Hospital (CSH) between January 1, 2006, and August 30, 2009. Results. Ibn Sina CSH received 225 burn casualties between January 2006 and August 2009. Of these, 48 met the inclusion criteria. The mean Injury Severity Score was 31.7 (range 4 to 75). Prehospital vascular access was obtained in 24 casualties (50%), and 20 of the casualties received fluid resuscitation. Out of the 48 casualties enrolled, 28 (58.3%) did not receive prehospital fluid resuscitation. Of the casualties who received fluid resuscitation, nearly all received volumes in excess of the guidelines established by the American Burn Association and those recommended by the Committee for Tactical Combat Casualty Care. With regard to pain management in the prehospital setting, 13 casualties (27.1%) received pain medication. Conclusions. With regard to the prehospital fluid resuscitation of primary thermal injury in the combat zone, two extremes were noted. The first group did not receive any fluid resuscitation; the second group was resuscitated with fluid volumes higher than those expected if established guidelines were utilized. Pain management was not uniformly provided to major burn casualties, even in several with vascular access. These observations support improved education of prehospital personnel serving in a combat zone. C1 [Lairet, Kimberly F.; King, Booker T.; Renz, Evan M.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Lairet, Julio R.] San Antonio Mil Med Ctr, Dept Emergency Med, San Antonio, TX USA. RP Lairet, KF (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM kimberly.franzen@us.army.mil NR 10 TC 5 Z9 6 U1 0 U2 6 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD APR-JUN PY 2012 VL 16 IS 2 BP 273 EP 276 DI 10.3109/10903127.2011.640417 PG 4 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 899BU UT WOS:000300788700013 PM 22191659 ER PT J AU Sharp, JA McAnally, WH AF Sharp, Jeremy A. McAnally, William H. TI Numerical modeling of surge overtopping of a levee SO APPLIED MATHEMATICAL MODELLING LA English DT Article DE Levee; Overtopping; Numerical modeling; Adaptive Hydraulics Model ID OVERFLOW AB Levee protection/armoring is critical in flood fighting, and understanding the flow characteristics involved requires the evaluation of the overtopping processes with a variety of tools. The Adaptive Hydraulics Model (AdH) is used to calculate velocity and depth during an overtopping event. Using these values, the work explores the application of AdH for the estimation of associated shear stresses, so that appropriate measures are applied for protection to ultimately reduce the probability of levee failure during an overtopping event. Four different depths and three Manning's n values were used for a total of twelve different test cases. Results show mean shear stress increases with increased surge depth and roughness. Additionally, the area of greatest shear stress is shown to be at the slope transitions from levee to berm. Values calculated in this effort should be considered in the design and implementation of levee protection. Published by Elsevier Inc. C1 [Sharp, Jeremy A.] USA, Engn Res & Dev Ctr Coastal, Hydraul Lab River Engn Branch, Vicksburg, MS 39183 USA. [McAnally, William H.] Dept Civil Engn, Mississippi State, MS 39762 USA. RP Sharp, JA (reprint author), USA, Engn Res & Dev Ctr Coastal, Hydraul Lab River Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39183 USA. EM Jeremy.A.Sharp@usace.army.mil; Mcanally@cee.msstate.edu FU Department of Homeland Security; Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory; Mississippi State University [70015] FX This research was funded by the Department of Homeland Security and sponsored by the Southeast Region Research Initiative (SERRI) at the Department of Energy's Oak Ridge National Laboratory. This research was performed under Project Number 70015 through Mississippi State University and principal investigator Isaac L Howard. NR 23 TC 2 Z9 3 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0307-904X J9 APPL MATH MODEL JI Appl. Math. Model. PD APR PY 2012 VL 36 IS 4 BP 1359 EP 1370 DI 10.1016/j.apm.2011.08.039 PG 12 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA 890BU UT WOS:000300120900002 ER PT J AU Baumgart-Getz, A Prokopy, LS Floress, K AF Baumgart-Getz, Adam Prokopy, Linda Stalker Floress, Kristin TI Why farmers adopt best management practice in the United States: A meta-analysis of the adoption literature SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE Adoption; Diffusion; Agricultural BMPs; Meta-analysis; Water quality ID CONSERVATION PRACTICES; TECHNOLOGY ADOPTION; ENVIRONMENTAL IMPLICATIONS; MINIMUM TILLAGE; DECISIONS; BEHAVIOR; DETERMINANTS; WATERSHEDS; DIFFUSION; PROGRAMS AB This meta-analysis of both published and unpublished studies assesses factors believed to influence adoption of agricultural Best Management Practices in the United States. Using an established statistical technique to summarize the adoption literature in the United States, we identified the following variables as having the largest impact on adoption: access to and quality of information, financial capacity, and being connected to agency or local networks of farmers or watershed groups. This study shows that various approaches to data collection affect the results and comparability of adoption studies. In particular, environmental awareness and farmer attitudes have been inconsistently used and measured across the literature. This meta-analysis concludes with suggestions regarding the future direction of adoption studies, along with guidelines for how data should be presented to enhance the adoption of conservation practices and guide research. Published by Elsevier Ltd. C1 [Baumgart-Getz, Adam] USA, US Geol Survey, Natl Wetland Res Ctr, New Orleans, LA 70118 USA. [Prokopy, Linda Stalker] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA. [Floress, Kristin] Univ Wisconsin Stevens Point, Coll Nat Resources, Stevens Point, WI 54481 USA. RP Baumgart-Getz, A (reprint author), USA, US Geol Survey, Natl Wetland Res Ctr, 7400 Leake Ave, New Orleans, LA 70118 USA. EM baumgart-getza@usgs.gov; lprokopy@purdue.edu; kristin.floress@uwsp.edu RI Prokopy, Linda/D-4900-2013 OI Prokopy, Linda/0000-0001-7076-0046 NR 72 TC 76 Z9 76 U1 7 U2 114 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD APR PY 2012 VL 96 IS 1 BP 17 EP 25 DI 10.1016/j.jenvman.2011.10.006 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 898OQ UT WOS:000300752100003 PM 22208394 ER PT J AU Zhang, HC Nasrabadi, NM Zhang, YN Huang, TS AF Zhang, Haichao Nasrabadi, Nasser M. Zhang, Yanning Huang, Thomas S. TI Joint dynamic sparse representation for multi-view face recognition SO PATTERN RECOGNITION LA English DT Article DE Multi-view face recognition; Joint dynamic sparsity; Joint dynamic sparse representation based classification ID PATTERN-RECOGNITION; CLASSIFICATION; EIGENFACES; VISION AB We consider the problem of automatically recognizing a human face from its multi-view images with unconstrained poses. We formulate the multi-view face recognition task as a joint sparse representation model and take advantage of the correlations among the multiple views for face recognition using a novel joint dynamic sparsity prior. The proposed joint dynamic sparsity prior promotes shared joint sparsity patterns among the multiple sparse representation vectors at class-level, while allowing distinct sparsity patterns at atom-level within each class to facilitate a flexible representation. Extensive experiments on the CMU Multi-PIE face database are conducted to verify the efficacy of the proposed method. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Zhang, Haichao; Zhang, Yanning] Northwestern Polytech Univ, Sch Comp Sci, Xian 710129, Peoples R China. [Zhang, Haichao; Huang, Thomas S.] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA. [Huang, Thomas S.] Univ Illinois, Coordinated Sci Lab, Urbana, IL 61801 USA. [Huang, Thomas S.] Univ Illinois, Beckman Inst Adv Sci He Technol, Urbana, IL 61801 USA. [Huang, Thomas S.] Univ Illinois, Inst Major Res Theme Human Comp Intelligent Inter, Urbana, IL 61801 USA. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD USA. RP Zhang, HC (reprint author), Northwestern Polytech Univ, Sch Comp Sci, Xian 710129, Peoples R China. EM hczhang1@gmail.com FU National Natural Science Foundation of China [60872145, 60903126]; National High Technology Research and Development Program (863) of China [2009AA01Z315]; China Postdoctoral (Special) Science Foundation [20090451397, 201003685]; Ministry of Education of China [708085]; U.S. Army Research Laboratory and U.S. Army Research Office [W911NF-09-1-0383] FX We would like to thank all the anonymous reviewers for their constructive comments. This work is supported by the National Natural Science Foundation of China (Nos. 60872145, 60903126), National High Technology Research and Development Program (863) of China (No. 2009AA01Z315), China Postdoctoral (Special) Science Foundation (Nos. 20090451397, 201003685) and Cultivation Fund of the Key Scientific and Technical Innovation Project from Ministry of Education of China (No. 708085). The work is also supported by the U.S. Army Research Laboratory and U.S. Army Research Office under Grant no. W911NF-09-1-0383. NR 25 TC 43 Z9 52 U1 4 U2 25 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0031-3203 J9 PATTERN RECOGN JI Pattern Recognit. PD APR PY 2012 VL 45 IS 4 BP 1290 EP 1298 DI 10.1016/j.patcog.2011.09.009 PG 9 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 894WU UT WOS:000300459000006 ER PT J AU Wansink, B Shimizu, M Cardello, AV Wright, AO AF Wansink, Brian Shimizu, Mitsuru Cardello, Armand V. Wright, Alan O. TI Dining in the dark: How uncertainty influences food acceptance in the absence of light SO FOOD QUALITY AND PREFERENCE LA English DT Article DE Sight; Uncertainty; Darkness; Food acceptance; Food intake ID CONSUMPTION; BEHAVIOR; CHOICE AB Sensory cues such as the visual appearance of foods can have a significant effect on food acceptance and food intake. Yet there are many situations - such as those involving deployed soldiers, night workers, and nighttime snackers - where such cues are masked by darkness. This study examines how and why darkness negatively influences food acceptance and future intake and what can be done to mitigate any potential problem. The results show that ambiguous foods eaten in the dark conditions have a low level of acceptance, which may be mediated by one's uncertainty about the food. Using clear product information (through packaging and labeling, for instance) can reduce this uncertainty and increase acceptance as well as future intake. Interpretations of these findings are discussed and their implications are underscored for those situations where individuals often eat in darkness. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Wansink, Brian; Shimizu, Mitsuru] Cornell Univ, Dyson Sch Appl Econ & Management, Ithaca, NY 14850 USA. [Cardello, Armand V.; Wright, Alan O.] USA, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. RP Shimizu, M (reprint author), Cornell Univ, Dyson Sch Appl Econ & Management, 110 Warren Hall, Ithaca, NY 14850 USA. EM wansink@cornell.edu; ms925@cornell.edu; armand.cardello@us.army.mil; alan.wright@us.army.mil NR 18 TC 7 Z9 7 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0950-3293 J9 FOOD QUAL PREFER JI Food. Qual. Prefer. PD APR PY 2012 VL 24 IS 1 BP 209 EP 212 DI 10.1016/j.foodqual.2011.09.002 PG 4 WC Food Science & Technology SC Food Science & Technology GA 881AJ UT WOS:000299451400026 ER PT J AU Nissan, A Stojadinovic, A Mitrani-Rosenbaum, S Halle, D Grinbaum, R Roistacher, M Bochem, A Dayanc, BE Ritter, G Gomceli, I Bostanci, EB Akoglu, M Chen, YT Old, LJ Gure, AO AF Nissan, Aviram Stojadinovic, Alexander Mitrani-Rosenbaum, Stella Halle, David Grinbaum, Ronit Roistacher, Marina Bochem, Andrea Dayanc, Baris Emre Ritter, Gerd Gomceli, Ismail Bostanci, Erdal Birol Akoglu, Musa Chen, Yao-Tseng Old, Lloyd John Gure, Ali Osmay TI Colon cancer associated transcript-1: A novel RNA expressed in malignant and pre-malignant human tissues SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE colorectal cancer; non-coding RNA; biomarkers; minimal residual disease ID GENOME-WIDE ASSOCIATION; HUMAN COLORECTAL-CANCER; LONG-RANGE INTERACTION; IMPRINTED H19 GENE; FECAL-OCCULT-BLOOD; DNA METHYLATION; PROSTATE-CANCER; HUMAN CDNAS; RISK LOCI; 8Q24 AB Early detection of colorectal cancer (CRC) is currently based on fecal occult blood testing (FOBT) and colonoscopy, both which can significantly reduce CRC-related mortality. However, FOBT has low-sensitivity and specificity, whereas colonoscopy is labor- and cost-intensive. Therefore, the discovery of novel biomarkers that can be used for improved CRC screening, diagnosis, staging and as targets for novel therapies is of utmost importance. To identify novel CRC biomarkers we utilized representational difference analysis (RDA) and characterized a colon cancer associated transcript (CCAT1), demonstrating consistently strong expression in adenocarcinoma of the colon, while being largely undetectable in normal human tissues (p < 000.1). CCAT1 levels in CRC are on average 235-fold higher than those found in normal mucosa. Importantly, CCAT1 is strongly expressed in tissues representing the early phase of tumorigenesis: in adenomatous polyps and in tumor-proximal colonic epithelium, as well as in later stages of the disease (liver metastasis, for example). In CRC-associated lymph nodes, CCAT1 overexpression is detectable in all H&E positive, and 40.0% of H&E and immunohistochemistry negative lymph nodes, suggesting very high sensitivity. CCAT1 is also overexpressed in 40.0% of peripheral blood samples of patients with CRC but not in healthy controls. CCAT1 is therefore a highly specific and readily detectable marker for CRC and tumor-associated tissues. C1 [Nissan, Aviram; Halle, David; Grinbaum, Ronit; Roistacher, Marina; Bochem, Andrea] Hadassah Hebrew Univ, Surg Oncol Lab, Dept Surg, Med Ctr, IL-91240 Jerusalem, Israel. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Div Surg Oncol, Dept Surg, Washington, DC 20307 USA. [Mitrani-Rosenbaum, Stella] Hadassah Hebrew Univ, Goldyne Savad Inst Gene Therapy, Med Ctr, IL-91240 Jerusalem, Israel. [Dayanc, Baris Emre; Gure, Ali Osmay] Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey. [Ritter, Gerd; Old, Lloyd John] Mem Sloan Kettering Canc Ctr, New York Branch, Ludwig Inst Canc Res, New York, NY 10021 USA. [Gomceli, Ismail; Bostanci, Erdal Birol; Akoglu, Musa] Yuksek Ihtisas Training & Res Hosp, Dept Surg Gastroenterol, Ankara, Turkey. [Chen, Yao-Tseng] Weill Cornell Med Ctr, Dept Pathol, New York, NY USA. RP Nissan, A (reprint author), Hadassah Hebrew Univ, Dept Surg, Med Ctr Mt Scopus, POB 24035, IL-91240 Jerusalem, Israel. EM anissan@hadassah.org.il; agure@bilkent.edu.tr RI perumal, murugiah/D-1565-2012; Dayanc, Emre/E-8726-2010 FU Hadassah-Hebrew University Medical Center; Ludwig Institute for Cancer Research FX Grant sponsors: Hadassah-Hebrew University Medical Center, Ludwig Institute for Cancer Research NR 34 TC 58 Z9 64 U1 2 U2 19 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0020-7136 J9 INT J CANCER JI Int. J. Cancer PD APR 1 PY 2012 VL 130 IS 7 BP 1598 EP 1606 DI 10.1002/ijc.26170 PG 9 WC Oncology SC Oncology GA 883KQ UT WOS:000299633300013 PM 21547902 ER PT J AU Eppinger, M Radnedge, L Andersen, G Vietri, N Severson, G Mou, S Ravel, J Worsham, PL AF Eppinger, Mark Radnedge, Lyndsay Andersen, Gary Vietri, Nicholas Severson, Grant Mou, Sherry Ravel, Jacques Worsham, Patricia L. TI Novel Plasmids and Resistance Phenotypes in Yersinia pestis: Unique Plasmid Inventory of Strain Java 9 Mediates High Levels of Arsenic Resistance SO PLOS ONE LA English DT Article ID COMPLETE GENOME SEQUENCE; LACTOSE TRANSPOSON TN951; ESCHERICHIA-COLI; ARS OPERON; SMALL MAMMALS; DNA-SEQUENCE; WEST JAVA; PLAGUE; VIRULENCE; EVOLUTION AB Growing evidence suggests that the plasmid repertoire of Yersinia pestis is not restricted to the three classical virulence plasmids. The Java 9 strain of Y. pestis is a biovar Orientalis isolate obtained from a rat in Indonesia. Although it lacks the Y. pestis-specific plasmid pMT, which encodes the F1 capsule, it retains virulence in mouse and non-human primate animal models. While comparing diverse Y. pestis strains using subtractive hybridization, we identified sequences in Java 9 that were homologous to a Y. enterocolitica strain carrying the transposon Tn2502, which is known to encode arsenic resistance. Here we demonstrate that Java 9 exhibits high levels of arsenic and arsenite resistance mediated by a novel promiscuous class II transposon, named Tn2503. Arsenic resistance was self-transmissible from Java 9 to other Y. pestis strains via conjugation. Genomic analysis of the atypical plasmid inventory of Java 9 identified pCD and pPCP plasmids of atypical size and two previously uncharacterized cryptic plasmids. Unlike the Tn2502-mediated arsenic resistance encoded on the Y. enterocolitica virulence plasmid; the resistance loci in Java 9 are found on all four indigenous plasmids, including the two novel cryptic plasmids. This unique mobilome introduces more than 105 genes into the species gene pool. The majority of these are encoded by the two entirely novel self-transmissible plasmids, which show partial homology and synteny to other enterics. In contrast to the reductive evolution in Y. pestis, this study underlines the major impact of a dynamic mobilome and lateral acquisition in the genome evolution of the plague bacterium. C1 [Eppinger, Mark; Ravel, Jacques] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. [Eppinger, Mark; Ravel, Jacques] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA. [Radnedge, Lyndsay; Andersen, Gary] Lawrence Livermore Natl Lab, Livermore, CA USA. [Vietri, Nicholas; Severson, Grant; Mou, Sherry; Worsham, Patricia L.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Eppinger, M (reprint author), Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. EM jravel@som.umaryland.edu; patricia.worsham@us.army.mil OI Ravel, Jacques/0000-0002-0851-2233 FU Defense Threat Reduction Agency [05-4-5A-0AC]; Department of the Army [TB1-5A]; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200900007C] FX This work was supported in part with federal funds from the Defense Threat Reduction Agency (Project 05-4-5A-0AC), the Department of the Army (Project number TB1-5A) and from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under contract number HHSN272200900007C. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 69 TC 7 Z9 9 U1 1 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 30 PY 2012 VL 7 IS 3 AR e32911 DI 10.1371/journal.pone.0032911 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 959UC UT WOS:000305339100023 PM 22479347 ER PT J AU Ervin, MH Miller, BS Hanrahan, B Mailly, B Palacios, T AF Ervin, Matthew H. Miller, Benjamin S. Hanrahan, Brendan Mailly, Benjamin Palacios, Tomas TI A comparison of single-wall carbon nanotube electrochemical capacitor electrode fabrication methods SO ELECTROCHIMICA ACTA LA English DT Article DE Carbon nanotube; Graphene; Supercapacitor; Fabrication method ID SUPERCAPACITORS; PAPER AB Carbon nanotubes (CNTs) are being widely investigated as a replacement for activated carbon in supercapacitors. A wide range of CNT specific capacitances have been reported in the literature based on experiments using different CNT materials, fabrication methods, and characterization routines; making it difficult to draw conclusions about the relative merits of the different fabrication methods. This work systematically compares four solution-based electrode fabrication methods (drop casting, air brushing, filtration, and electrospraying) and, to a lesser extent, some solution preparation techniques to determine if there is an optimum method for fabricating electrochemical capacitor electrodes out of single-wall CNTs (SWCNTs). We have found that it is best to use CNT solutions free from additives that may be difficult to remove from the fabricated electrode. In addition, the CNT solution preparation (e.g., dilution and sonication) had little effect on the resulting specific capacitance. Large differences in performance due to the fabrication methods were not seen, and the differences that were seen could be ascribed to material loss or contamination during the deposition. A single-layer graphene electrode was also fabricated and tested to obtain an estimate of the specific capacitance potentially achievable with SWCNTs. with 550 F/g demonstrated using 1 molar (M) sulfuric acid. Published by Elsevier Ltd. C1 [Ervin, Matthew H.; Miller, Benjamin S.; Hanrahan, Brendan] USA, Res Lab, Adelphi, MD 20783 USA. [Mailly, Benjamin; Palacios, Tomas] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA. RP Ervin, MH (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Matthew.H.Ervin.Civ@Mail.mil RI Mohd Jasni, Mohamad Redwani/E-7555-2015; OI Mohd Jasni, Mohamad Redwani/0000-0003-4036-4856; Miller, Benjamin/0000-0003-1647-0122 NR 15 TC 17 Z9 17 U1 3 U2 55 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD MAR 30 PY 2012 VL 65 BP 37 EP 43 DI 10.1016/j.electacta.2012.01.060 PG 7 WC Electrochemistry SC Electrochemistry GA 912NJ UT WOS:000301806600007 ER PT J AU Gilman, S AF Gilman, S. TI Study of acetate adsorption at the platinum electrode/acid electrolyte interface using "blocking effects": Influences of acetate adsorption on ethanol fuel cell electrodes SO ELECTROCHIMICA ACTA LA English DT Article DE Ion adsorption; Acetate ion adsorption; Acetic acid; Ethanol fuel cell ID POTENTIODYNAMIC M.P.P. METHOD; SINGLE-CRYSTAL ELECTRODES; TIME FTIR SPECTROSCOPY; ANION ADSORPTION; ACETIC-ACID; ELECTROOXIDATION; OXIDATION; ACETALDEHYDE; MECHANISM; SURFACES AB This manuscript describes results using a novel electrochemical approach that utilizes pulse sequences and surface blocking effects for the quantitative study of the accumulation of acetate ions and the influence of ethanol and molecular oxygen on those accumulations at a polycrystalline platinum electrode. The electrochemical properties of acetic acid are of special interest in connection with ethanol fuel cell technology where it is the main product of incomplete ethanol oxidation in laboratory fuel cells. Acetic acid adsorbs as the anion on a platinum electrode in an acid electrolyte. Adsorbed acetate ions block oxygen adsorption during an anodic potential scan, with a stoichiometry of two oxygen adsorption sites per adsorbed acetate ion. Use of this "blocking effect" has enabled the first-time determination of rates of acetate adsorption and desorption and of an adsorption isotherm normalized with respect to available surface sites. The ethanol adlayer is comprised of acetate and species other than acetate that block hydrogen adsorption during a cathodic scan while adsorbed acetate does not. Use of a combination of the "blocking effects" has enabled the first-time quantitative determination of the interaction between the two types of adsorbed species. Adsorbed acetate significantly impedes both ethanol oxidation and molecular oxygen reduction in fuel cells. Published by Elsevier Ltd. C1 USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Gilman, S (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sol.gilman.civ@mail.mil NR 38 TC 6 Z9 6 U1 2 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD MAR 30 PY 2012 VL 65 BP 141 EP 148 DI 10.1016/j.electacta.2012.01.016 PG 8 WC Electrochemistry SC Electrochemistry GA 912NJ UT WOS:000301806600020 ER PT J AU Takahashi, N Tanabe, K Tsukahara, T Dzodzomenyo, M Dysoley, L Khamlome, B Sattabongkot, J Nakamura, M Sakurai, M Kobayashi, J Kaneko, A Endo, H Hombhanje, F Tsuboi, T Mita, T AF Takahashi, Nobuyuki Tanabe, Kazuyuki Tsukahara, Takahiro Dzodzomenyo, Mawuli Dysoley, Lek Khamlome, Boualam Sattabongkot, Jetsumon Nakamura, Masatoshi Sakurai, Miki Kobayashi, Jun Kaneko, Akira Endo, Hiroyoshi Hombhanje, Francis Tsuboi, Takafumi Mita, Toshihiro TI Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt SO MALARIA JOURNAL LA English DT Article DE Plasmodium falciparum; Chloroquine resistance; pfcrt; Microsatellite; Haplotype network; Evolution ID MALARIA PARASITES; TRANSPORTER GENE; MALAWI; ALLELES; SENSITIVITY; MUTATIONS; PHILIPPINES; PREVALENCE; DIVERSITY; PATTERNS AB Background: In Plasmodium falciparum, resistance to chloroquine (CQ) is conferred by a K to T mutation at amino acid position 76 (K76T) in the P. falciparum CQ transporter (PfCRT). To date, at least 15 pfcrt genotypes, which are represented by combinations of five amino acids at positions 72-76, have been described in field isolates from various endemic regions. To identify novel mutant pfcrt genotypes and to reveal the genetic relatedness of pfcrt genotypes, a large-scale survey over a wide geographic area was performed. Methods: Sequences for exon 2 in pfcrt, including known polymorphic sites at amino acid positions 72, 74, 75 and 76, were obtained from 256 P. falciparum isolates collected from eight endemic countries in Asia (Bangladesh, Cambodia, Lao P. D. R., the Philippines and Thailand), Melanesia (Papua New Guinea and Vanuatu) and Africa (Ghana). A haplotype network was constructed based on six microsatellite markers located -29 kb to 24 kb from pfcrt in order to examine the genetic relatedness among mutant pfcrt genotypes. Results: In addition to wild type (CVMNK at positions 72-76), four mutant pfcrt were identified; CVIET, CVIDT, SVMNT and CVMNT (mutated amino acids underlined). Haplotype network revealed that there were only three mutant pfcrt lineages, originating in Indochina, Philippines and Melanesia. Importantly, the Indochina lineage contained two mutant pfcrt genotypes, CVIET (n = 95) and CVIDT (n = 14), indicating that CVIDT shares a common origin with CVIET. Similarly, one major haplotype in the Melanesian lineage contained two pfcrt genotypes; SVMNT (n = 71) and CVMNT (n = 3). In Africa, all mutant pfcrt genotypes were the CVIET of the Indochina lineage, probably resulting from the intercontinental migration of CQ resistance from Southeast Asia. Conclusions: The number of CQ-mutant lineages observed in this study was identical to that found in previous studies. This supports the hypothesis that the emergence of novel CQ resistance is rare. However, in the mutant pfcrt genotypes, amino acid changes at positions 72, 74 and 75 appear to have recently been generated at least several times, producing distinct pfcrt mutant genotypes. The occurrence of new mutations flanking K76T may yield stronger resistance to CQ and/or a higher fitness than the original pfcrt mutant. C1 [Takahashi, Nobuyuki; Tsukahara, Takahiro; Sakurai, Miki; Endo, Hiroyoshi; Mita, Toshihiro] Tokyo Womens Med Univ, Dept Int Affairs & Trop Med, Sch Med, Shinjuku Ku, Tokyo 1628666, Japan. [Tanabe, Kazuyuki] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Suita, Osaka 565, Japan. [Dzodzomenyo, Mawuli] Univ Ghana, Dept Biol Environm & Occupat Hlth Sci, Sch Publ Hlth, Legon, Ghana. [Dysoley, Lek] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Pehn, Cambodia. [Khamlome, Boualam] Minist Hlth, Prevent Div, Hyg Prevent Dept, Viangchan, Laos. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Nakamura, Masatoshi] Dokkyo Med Univ, Dept Trop Med & Parasitol, Mibu, Tochigi, Japan. [Kobayashi, Jun] Nagasaki Univ, Grad Sch Int Hlth Dev, Nagasaki 852, Japan. [Kaneko, Akira] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden. [Kaneko, Akira] Osaka City Univ, Dept Parasitol, Grad Sch Med, Osaka 558, Japan. [Kaneko, Akira] Nagasaki Univ, Inst Trop Med, Nagasaki 852, Japan. [Hombhanje, Francis] Divine Word Univ, Ctr Hlth Res, Madang, Papua N Guinea. [Tsuboi, Takafumi] Ehime Univ, Cell free Sci & Technol Res Ctr, Matsuyama, Ehime, Japan. [Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime, Japan. RP Mita, T (reprint author), Tokyo Womens Med Univ, Dept Int Affairs & Trop Med, Sch Med, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan. EM hiro-tm@research.twmu.ac.jp OI , Akira/0000-0003-2411-3352 FU Ministry of Education, Culture, Sports, Science and Technology of Japan [22406012, 23650211, 23590498] FX We would like to thank all participants in this study, and Hikota Osawa, Ilomo Hwaihwanje, and Aung Swi Prue Marma for their assistance with the field work. This study was supported by Grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan [22406012, 23650211 and 23590498]. NR 39 TC 8 Z9 9 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAR 28 PY 2012 VL 11 AR 92 DI 10.1186/1475-2875-11-92 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 956JK UT WOS:000305085700001 PM 22453078 ER PT J AU Uchimiya, M Wartelle, LH Boddu, VM AF Uchimiya, Minori Wartelle, Lynda H. Boddu, Veera M. TI Sorption of Triazine and Organophosphorus Pesticides on Soil and Biochar SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE organophosphorus pesticide; deisopropylatrazine; competitive sorption; degradation; hysteresis; surface area ID CATALYZED-HYDROLYSIS; CONTROLLED-RELEASE; ORGANIC-COMPOUNDS; FUNCTIONAL-GROUPS; HEAVY-METALS; BLACK CARBON; WATER; ADSORPTION; DEGRADATION; HYSTERESIS AB Sorption and degradation are the primary processes controlling the efficacy and runoff contamination risk of agrochemicals. Considering the longevity of biochar in agroecosystems, biochar soil amendment must be carefully evaluated on the basis of the target agrochemical and soil types to achive agricultural (minimum impact on efficacy) and environmental (minimum runoff contamination) benefits. In this study, sorption-desorption isotherms and kinetics of triazine (deisopropylatrazine) and organophosphorus (malathion, parathion, and diazinon) pesticides were first investigated on various soil types ranging from clayey, acidic Puerto Rican forest soil (PR) to heavy metal contaminated small arms range (SAR) soils of sandy and peaty nature. On PR, malathion sorption did not reach equilibrium during the 3 week study. Comparison of solution-phase molar phosphorus and agrochemical concentrations suggested that degradation products of organophosphorus pesticides were bound on soil surfaces. The degree of sorption on different soils showed the following increasing trend: deisopropylatrazine < malathion < diazinon < parathion. While sorption of deisopropylatrazine on SAR soils was not affected by diazinon or malathion, deisopropylatrazine suppressed the sorption of diazinon and malathion. Deisopropylatrazine irreversibly sorbed on biochars, and greater sorption was observed with higher Brunauer-Emmett-Teller surface area of biochar (4.7-2061 mg g(-1)). The results suggested the utility of biochar for remediation of sites where concentrations of highly stable and mobile agrochemicals exceed the water-quality benchmarks. C1 [Uchimiya, Minori; Wartelle, Lynda H.] USDA ARS, So Reg Res Ctr, New Orleans, LA 70124 USA. [Boddu, Veera M.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Uchimiya, M (reprint author), USDA ARS, So Reg Res Ctr, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA. EM sophie.uchimiya@ars.usda.gov FU Defense Threat Reduction Agency [CBS.SIM.03.10.ER.PP.002] FX This work was partially funded by the Defense Threat Reduction Agency Project #CBS.SIM.03.10.ER.PP.002. NR 51 TC 33 Z9 33 U1 11 U2 136 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD MAR 28 PY 2012 VL 60 IS 12 BP 2989 EP 2997 DI 10.1021/jf205110g PG 9 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 914RM UT WOS:000301969300006 PM 22394556 ER PT J AU Ding, H Chen, G Xu, Z Sadler, BM AF Ding, H. Chen, G. Xu, Z. Sadler, B. M. TI Channel modelling and performance of non-line-of-sight ultraviolet scattering communications SO IET COMMUNICATIONS LA English DT Article ID AVALANCHE PHOTODIODES AB The solar-blind ultraviolet (UV) spectrum has useful properties for wireless communication and sensing. Strong atmospheric scattering in the UV spectrum enables non-line-of-sight (NLOS) communication. The authors present recent experimental and analytical results in NLOS UV channel modelling, including impulse response and path loss. The authors further study the NLOS UV link performance for short-range communication scenarios based on our theoretical modelling results. Relations between power limitation and channel bandwidth limitation are examined. Some link budget results are analysed for long-range communication links up to 5 km. C1 [Ding, H.; Chen, G.] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Xu, Z.] Dept Elect Engn, Adelphi, MD 20783 USA. [Xu, Z.] Tsinghua Natl Lab & Informat Sci & Technol, Adelphi, MD 20783 USA. [Sadler, B. M.] Army Res Lab, Adelphi, MD 20783 USA. RP Ding, H (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dinghaipeng@gmail.com; gachen@ee.ucr.edu; xuzy@tsinghua.edu.cn; brian.m.sadler6.civ@mail.mil RI Ding, Haipeng/B-7742-2014 FU National Natural Science Foundation of China [61171066]; Tsinghua National Laboratory for Information Science and Technology (TNLIST) Cross Discipline Foundation [2011Z02289] FX This work was supported in part by National Natural Science Foundation of China under Grant 61171066, Tsinghua National Laboratory for Information Science and Technology (TNLIST) Cross Discipline Foundation under Grant 2011Z02289. NR 21 TC 6 Z9 10 U1 2 U2 7 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8628 J9 IET COMMUN JI IET Commun. PD MAR 27 PY 2012 VL 6 IS 5 BP 514 EP 524 DI 10.1049/iet-com.2011.0026 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA 949YB UT WOS:000304613100008 ER PT J AU Tsurupa, G Pechik, I Litvinov, RI Hantgan, RR Tjandra, N Weisel, JW Medved, L AF Tsurupa, Galina Pechik, Igor Litvinov, Rustem I. Hantgan, Roy R. Tjandra, Nico Weisel, John W. Medved, Leonid TI On the Mechanism of alpha C Polymer Formation in Fibrin SO BIOCHEMISTRY LA English DT Article ID AMINO-ACID-SEQUENCE; FIBRONECTIN-BINDING; BOVINE FIBRINOGEN; STRUCTURAL ORGANIZATION; ELECTRON-MICROSCOPY; DOMAIN FRAGMENT; CROSS-LINKING; FACTOR-XIIIA; SITES; CHAIN AB Our previous studies revealed that the fibrinogen alpha C-domains undergo conformational changes and adopt a physiologically active conformation upon their self-association into alpha C polymers in fibrin. In the present study, we analyzed the mechanism of alpha C polymer formation and tested our hypothesis that self-association of the alpha C-domains occurs through the interaction between their N-terminal subdomains and may include beta-hairpin swapping. Our binding experiments performed by size-exclusion chromatography and optical trap-based force spectroscopy revealed that the alpha C-domains self-associate exclusively through their N-terminal subdomains, while their C-terminal subdomains were found to interact with the alpha C-connectors that tether the alpha C-domains to the bulk of the molecule. This interaction should reinforce the structure of alpha C polymers and provide the proper orientation of their reactive residues for efficient cross-linking by factor XIIIa. Molecular modeling of self-association of the N-terminal subdomains confirmed that the hypothesized beta-hairpin swapping does not impose any steric hindrance. To "freeze" the conformation of the N-terminal subdomain and prevent the hypothesized beta-hairpin swapping, we introduced by site-directed mutagenesis an extra disulfide bond between two beta-hairpins of the bovine A alpha 406-483 fragment corresponding to this subdomain. The experiments performed by circular dichroism revealed that A alpha 406-483 mutant containing Lys429Cys/Thr463Cys mutations preserved its beta-sheet structure. However, in contrast to wild-type A alpha 406-483, this mutant had lower tendency for oligomerization, and its structure was not stabilized upon oligomerization, in agreement with the above hypothesis. On the basis of the results obtained and our previous findings, we propose a model of fibrin alpha C polymer structure and molecular mechanism of assembly. C1 [Tsurupa, Galina; Medved, Leonid] Univ Maryland, Ctr Vasc & Inflammatory Dis, Sch Med, Baltimore, MD 21201 USA. [Tsurupa, Galina; Medved, Leonid] Univ Maryland, Dept Biochem, Sch Med, Baltimore, MD 21201 USA. [Pechik, Igor] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Litvinov, Rustem I.; Weisel, John W.] Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Philadelphia, PA 19104 USA. [Hantgan, Roy R.] Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA. [Tjandra, Nico] NHLBI, Lab Mol Biophys, NIH, Bethesda, MD 20892 USA. RP Medved, L (reprint author), Univ Maryland, Ctr Vasc & Inflammatory Dis, Sch Med, Baltimore, MD 21201 USA. EM lmedved@som.umaryland.edu RI Litvinov, Rustem/E-5291-2011 OI Litvinov, Rustem/0000-0003-0643-1496 FU National Institutes of Health [HL056051, HL030954, HL090774]; National Heart Lung, and Blood Institute FX This work was supported by National Institutes of Health Grants HL056051 to L.M., HL030954 and HL090774 to J.W.W., and by the Intramural Research Program of the National Heart Lung, and Blood Institute to N.T. NR 54 TC 15 Z9 15 U1 0 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAR 27 PY 2012 VL 51 IS 12 BP 2526 EP 2538 DI 10.1021/bi2017848 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 914JQ UT WOS:000301946300017 PM 22397628 ER PT J AU Trabert, B Graubard, BI Erickson, RL McGlynn, KA AF Trabert, B. Graubard, B. I. Erickson, R. L. McGlynn, K. A. TI Childhood infections, orchitis and testicular germ cell tumours: a report from the STEED study and a meta-analysis of existing data SO BRITISH JOURNAL OF CANCER LA English DT Article DE testicular germ cell tumours; childhood infections; mumps; orchitis; case-control ID RISK-FACTORS; YOUNG MEN; CANCER; TESTIS; EPIDEMIOLOGY; ETIOLOGY AB BACKGROUND: Similarities between the age-specific incidence pattern of testicular germ cell tumours (TGCTs) and the age-specific incidence pattern of cancers of viral origin prompted us to evaluate the relationship between common infections occurring during childhood or young adult life and TGCT using existing data from the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) case-control study. METHODS: TGCT cases diagnosed between 2002 and 2005 (n = 767) were matched on age, race and serum draw date to at least one control (n = 929). RESULTS: None of the infections evaluated were associated with TGCT risk. Further, a meta-analysis of mumps and mumps orchitis or orchitis infection did not support an association with TGCT (mumps pooled odds ratio (OR): 1.03, 95% confidence interval (CI): 0.89-1.20; mumps orchitis or orchitis pooled OR: 1.80, 95% CI: 0.74-4.42). CONCLUSION: Based on our evaluation of childhood and early life infections and meta-analyses of mumps and mumps orchitis and/or orchitis, TGCT does not appear to be associated with common childhood infections. C1 [Trabert, B.; McGlynn, K. A.] NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Rockville, MD 20852 USA. [Graubard, B. I.] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,DHHS, Rockville, MD 20852 USA. [Erickson, R. L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Trabert, B (reprint author), NCI, Hormonal & Reprod Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,DHHS, 6120 Execut Blvd,Suite 550, Rockville, MD 20852 USA. EM trabertbl@mail.nih.gov RI Trabert, Britton/F-8051-2015 FU National Cancer Institute FX This work was supported by the Intramural Research Program of the National Cancer Institute. NR 21 TC 2 Z9 2 U1 0 U2 3 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 J9 BRIT J CANCER JI Br. J. Cancer PD MAR 27 PY 2012 VL 106 IS 7 BP 1331 EP 1334 DI 10.1038/bjc.2012.45 PG 4 WC Oncology SC Oncology GA 916VG UT WOS:000302130700012 PM 22343618 ER PT J AU Dye, JM Herbert, AS Kuehne, AI Barth, JF Muhammad, MA Zak, SE Ortiz, RA Prugar, LI Pratt, WD AF Dye, John M. Herbert, Andrew S. Kuehne, Ana I. Barth, James F. Muhammad, Majidat A. Zak, Samantha E. Ortiz, Ramon A. Prugar, Laura I. Pratt, William D. TI Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE passive antibody; polyclonal antibody; therapeutic agent; hemorrhagic fever virus ID EBOLA HEMORRHAGIC-FEVER; VIRUS INFECTION; NEUTRALIZING ANTIBODY; PASSIVE-IMMUNIZATION; CYNOMOLGUS MONKEYS; LASSA FEVER; IMMUNOGLOBULIN; IMMUNOTHERAPY; PATHOGENESIS; MACAQUES AB Antibody therapies to prevent or limit filovirus infections have received modest interest in recent years, in part because of early negative experimental evidence. We have overcome the limitations of this approach, leveraging the use of antibody from nonhuman primates (NHPs) that survived challenge to filoviruses under controlled conditions. By using concentrated, polyclonal IgG antibody from these survivors, we treated filovirus-infected NHPs with multiple doses administered over the clinical phase of disease. In the first study, Marburg virus (MARV)-infected NHPs were treated 15 to 30 min postexposure with virus-specific IgG, with additional treatments on days 4 and 8 postexposure. The postexposure IgG treatment was completely protective, with no signs of disease or detectable viremia. MARV-specific IgM antibody responses were generated, and all macaques survived rechallenge with MARV, suggesting that they generated an immune response to virus replication. In the next set of studies, NHPs were infected with MARV or Ebola virus (EBOV), and treatments were delayed 48 h, with additional treatments on days 4 and 8 postexposure. The delayed treatments protected both MARV- and EBOV-challenged NHPs. In both studies, two of the three IgG-treated NHPs had no clinical signs of illness, with the third NHP developing mild and delayed signs of disease followed by full recovery. These studies clearly demonstrate that postexposure antibody treatments can protect NHPs and open avenues for filovirus therapies for human use using established Food and Drug Administration-approved polyclonal or monoclonal antibody technologies. C1 [Dye, John M.; Herbert, Andrew S.; Kuehne, Ana I.; Barth, James F.; Muhammad, Majidat A.; Zak, Samantha E.; Ortiz, Ramon A.; Prugar, Laura I.; Pratt, William D.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Dye, JM (reprint author), USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM john.m.dye1@us.army.mil FU Defense Threat Reduction Agency [CBM.THRV.01.RD.11.001] FX The authors thank AI Biotech (Richmond, VA) for purification of IgG; Steven Bradfute (Arizona State University) and Kartik Chandran (Albert Einstein College of Medicine) for reviewing the manuscript; Gene Olinger [USAMRIID)] for providing the animal protocol for the initial MARV challenge; Jay Wells and Brian Hannah (USAMRIID), Keith Reimann (Harvard Medical School), and Alan Schmaljohn (University of Maryland) for helpful discussions on experimental design; and Josh Moore, Mike Winpigler, and Jimmy Fiallos (USAMRIID) for assisting with animal treatments. This work was supported by Defense Threat Reduction Agency Project CBM.THRV.01.RD.11.001. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 31 TC 120 Z9 126 U1 2 U2 30 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 27 PY 2012 VL 109 IS 13 BP 5034 EP 5039 DI 10.1073/pnas.1200409109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 917HT UT WOS:000302164200065 PM 22411795 ER PT J AU Meyers, RE Deacon, KS Shih, YH AF Meyers, Ronald E. Deacon, Keith S. Shih, Yanhua TI Positive-negative turbulence-free ghost imaging SO APPLIED PHYSICS LETTERS LA English DT Article ID LIGHT AB This experiment observed turbulence-free positive and negative thermal light ghost images from independently recorded event histories of a "bucket" photo-detector and a charged coupled device (CCD) array. The positive (negative) ghost image is computed from the "bucket" detector counts which are above (below) its mean, and the ghost image is not degraded by the turbulence. How do the "bucket" photon counts yield a positive or negative ghost image with a distant CCD array? This letter provides a quantum interference model which effectively explains the phenomenon. VC 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3698158] C1 [Meyers, Ronald E.; Deacon, Keith S.] USA, Res Lab, Adelphi, MD 20783 USA. [Shih, Yanhua] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. RP Meyers, RE (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM ronald.e.meyers6.civ@mail.mil FU US Army Research Laboratory [W911NF11-2-0074] FX R. M. and K. D. thank the US Army Research Laboratory for support and Arnold Tunick for helpful discussions. Y.H.S. thanks the US Army Research Laboratory, W911NF11-2-0074, for support and acknowledges helpful discussions with K. H. Luo and L. A. Wu on their positive-negative ghost imaging experiment. NR 10 TC 24 Z9 24 U1 1 U2 28 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 26 PY 2012 VL 100 IS 13 AR 131114 DI 10.1063/1.3698158 PG 4 WC Physics, Applied SC Physics GA 918DZ UT WOS:000302230800014 ER PT J AU Anandakathir, R Mosurkal, R Narkhede, M Kumar, J AF Anandakathir, Robinson Mosurkal, Ravi Narkhede, Mahesh Kumar, Jayant TI Synthesis and characterization of polysiloxane-functionalized cellulose as novel halogen-free flame retardant material SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Anandakathir, Robinson; Mosurkal, Ravi; Narkhede, Mahesh; Kumar, Jayant] Univ Massachusetts Lowell, Ctr Adv Mat, Lowell, MA 01854 USA. [Mosurkal, Ravi] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. [Narkhede, Mahesh] Univ Massachusetts Lowell, Dept Plast Engn, Lowell, MA 01854 USA. [Kumar, Jayant] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA. EM mahesh_narkhede@student.uml.edu RI MOSURKAL, RAVI/P-6981-2015 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 86-PMSE PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503203794 ER PT J AU Baker, DR Manocchi, AK Pendley, S Sumner, JJ Hurley, M Xu, K Bruce, BD Lundgren, CA AF Baker, David R. Manocchi, Amy K. Pendley, Scott Sumner, James J. Hurley, Margaret Xu, Kang Bruce, Barry D. Lundgren, Cynthia A. TI Photosystem I based solar cell for on-site hydrogen production SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Baker, David R.; Manocchi, Amy K.; Pendley, Scott; Sumner, James J.; Hurley, Margaret; Xu, Kang; Bruce, Barry D.; Lundgren, Cynthia A.] US Army Res Lab, Adelphi, MD 20783 USA. EM david.baker81.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 237-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475100770 ER PT J AU Banks, HD AF Banks, Harold D. TI Can graphene promote the self-assembly of hybrid nucleobases? SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Banks, Harold D.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM harold.banks@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 411-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503202613 ER PT J AU Bednar, AJ Poda, A Kennedy, A Johnson, D Mitrano, D Ranville, J AF Bednar, Anthony J. Poda, Aimee Kennedy, Alan Johnson, David Mitrano, Denise Ranville, James TI Characterization of nanoparticles in complex environmental matrices by field flow fractionation inductively coupled plasma mass spectrometry SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Bednar, Anthony J.; Poda, Aimee; Kennedy, Alan; Johnson, David] US Army Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA. [Mitrano, Denise; Ranville, James] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA. EM anthony.j.bednar@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 0 TC 0 Z9 0 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 455-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475103896 ER PT J AU Borodin, O AF Borodin, Oleg TI Lithium solvation and transport in bulk electrolytes and SEI components SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Borodin, Oleg] Army Res Lab, Electrochem Branch, Adelphi, MD USA. EM oleg.a.borodin.civ@mail.mil RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 250-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475104436 ER PT J AU Cureton, LT La Scala, JJ AF Cureton, LaShonda T. La Scala, John J. TI Bio-based polymeric materials SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Cureton, LaShonda T.; La Scala, John J.] US Army Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. EM lashonda.cureton.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 13-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475101337 ER PT J AU Dong, H Snyder, JF Orlicki, JA Reiner, RS Rudie, AW AF Dong, Hong Snyder, James F. Orlicki, Joshua A. Reiner, Richard S. Rudie, Alan W. TI Nanofibrillated cellulose structured materials functionalized with metal nanoparticles SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Dong, Hong; Snyder, James F.; Orlicki, Joshua A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Reiner, Richard S.; Rudie, Alan W.] US Forest Serv, Forest Prod Lab, USDA, Madison, WI 53726 USA. EM hong.dong.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 235-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475101552 ER PT J AU Dougherty, J Rinderspacher, BC Andzelm, JA Rawlett, A AF Dougherty, Joseph Rinderspacher, B. Christopher Andzelm, Jan A. Rawlett, Adam TI Synthesis of novel transparent electro-optic chromophores SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Dougherty, Joseph; Rinderspacher, B. Christopher; Andzelm, Jan A.; Rawlett, Adam] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM joseph.m.dougherty20.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 674-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503202870 ER PT J AU Gaidry, AD Gutteridge, CE O'Neil, MT AF Gaidry, Alicia D. Gutteridge, Clare E. O'Neil, Michael T. TI Preparation of more polar analogs of a novel chemical series with activity against the malaria parasite Plasmodium falciparum SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Gaidry, Alicia D.; Gutteridge, Clare E.] USN Acad, Dept Chem, Annapolis, MD 21401 USA. [O'Neil, Michael T.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM gutterid@usna.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 859-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475102551 ER PT J AU Halbur, J Krommenhoek, PJ Everitt, HO Tracy, JB Jur, JS AF Halbur, Jonathan Krommenhoek, Peter J. Everitt, Henry O. Tracy, Joseph B. Jur, Jesse S. TI Enabling of nanoparticle application and function on the surface of fibrous textiles by atomic layer deposition SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Halbur, Jonathan; Jur, Jesse S.] N Carolina State Univ, Dept Text Engn Chem & Sci, Raleigh, NC 27695 USA. [Krommenhoek, Peter J.; Tracy, Joseph B.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Everitt, Henry O.] US Army, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. EM jchalbur@ncsu.edu RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 585-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475104033 ER PT J AU Hill, CL Luo, Z Song, J Schreuder-Gibson, H Walker, JE AF Hill, Craig L. Luo, Zhen Song, Jie Schreuder-Gibson, Heidi Walker, John E. TI Polyoxometalate-treated fabrics: Materials that facilitate catalytic air-based decontamination SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Hill, Craig L.; Luo, Zhen; Song, Jie] Emory Univ, Atlanta, GA 30322 USA. [Schreuder-Gibson, Heidi; Walker, John E.] US Army Natick Soldier Ctr, Natick, MA 01760 USA. EM chill@emory.edu RI Song, Jie/J-6684-2016 OI Song, Jie/0000-0002-2461-3683 NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 531-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475103969 ER PT J AU Hill, FC Shukla, MK Gorb, L AF Hill, Frances C. Shukla, Manoj K. Gorb, Leonid TI Citrate coatings on metal nanoparticles: A computational study SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Hill, Frances C.; Shukla, Manoj K.] USA, Erdc, Vicksburg, MS 39180 USA. [Gorb, Leonid] Badger Tech Serv, Vicksburg, MS 39180 USA. EM Frances.C.Hill@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 168-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475103622 ER PT J AU Hindenlang, MD Knorr, DB Schoch, AB Fischer, DA Lenhart, JL AF Hindenlang, Mark D. Knorr, Daniel B. Schoch, Andrew B. Fischer, Daniel A. Lenhart, Joseph L. TI Chemical modifications at the epoxy/substrate interface: NEXAFS characterization and mechanical testing SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Hindenlang, Mark D.; Knorr, Daniel B.; Schoch, Andrew B.; Lenhart, Joseph L.] US Army Res Lab, Dept Def, Aberdeen Proving Ground, MD 21005 USA. [Fischer, Daniel A.] NIST, Dept Commerce, Gaithersburg, MD 20899 USA. EM mark.hindenlang.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 477-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503204714 ER PT J AU Hunter, JC Riegner, DE AF Hunter, Justin Cole Riegner, Dawn E. TI Characterization of solid phase microextraction (SPME) using field portable GC-MS for detection of explosive taggants EGDN and DMNB SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Hunter, Justin Cole; Riegner, Dawn E.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM justin.hunter@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 308-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475102023 ER PT J AU Isayev, O Hill, FC AF Isayev, Olexandr Hill, Frances C. TI Adsorption of energetic materials on graphene flakes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Isayev, Olexandr] Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA. [Isayev, Olexandr; Hill, Frances C.] US Army ERDC, Environm Lab, Vicksburg, MS 39180 USA. EM olexandr@olexandrisayev.com NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 82-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475104279 ER PT J AU Johnson, S Heckmann, E Gifford, J McCalmont, W Wickiser, JK AF Johnson, Seth Heckmann, Ethan Gifford, James McCalmont, William Wickiser, John K. TI Visual detection of cholera via modified E. coli SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Johnson, Seth; Heckmann, Ethan; Gifford, James; McCalmont, William; Wickiser, John K.] United States Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM seth.johnson@usma.edu; ethan.heckmann@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 1609-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475103284 ER PT J AU Kiserow, D AF Kiserow, Douglas TI Polymer Chemistry research at the US Army Research Office: Can you handle the truth? SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Kiserow, Douglas] Army Res Off, Durham, NC 27703 USA. EM douglas.j.kiserow.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 373-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503204618 ER PT J AU Lattao, CV Li, Y Pignatello, J Cao, XY Mao, JD Chappell, M Miller, LF dela Cruz, AL AF Lattao, Charisma V. Li, Yuan Pignatello, Joseph Cao, Xiaoyan Mao, Jingdong Chappell, Mark Miller, Lesley F. dela Cruz, Albert Leo TI Sorption selectivity of neutral organic compound to soil organic matter probed with nitroxyl paramagnetic NMR relaxation probes SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Lattao, Charisma V.; Pignatello, Joseph] Connecticut Agr Expt Stn, Dept Environm Sci, New Haven, CT 06504 USA. [Li, Yuan; Cao, Xiaoyan; Mao, Jingdong] Old Dominion Univ, Dept Chem, Norfolk, VA USA. [Chappell, Mark; Miller, Lesley F.] US Army Corps Engineers, Environm Lab, Vicksburg, MS USA. [dela Cruz, Albert Leo] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA. EM Charisma.Lattao@ct.gov RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 79-ENVR PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475104871 ER PT J AU Lipscomb, ML Lipscomb, TW Liao, H Maness, P Lynch, MD AF Lipscomb, Matthew L. Lipscomb, Tanya Warnecke Liao, Hans Maness, PinChing Lynch, Michael D. TI Production of fungible diesel via fatty acid synthesis from hydrogen and carbon dioxide feedstocks SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Lipscomb, Matthew L.; Lipscomb, Tanya Warnecke; Liao, Hans; Lynch, Michael D.] USA, OPXBIO, Washington, DC USA. [Maness, PinChing] USA, Natl Renewable Energy Lab, Washington, DC USA. EM mlipscomb@opxbio.com NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 63-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475100603 ER PT J AU McGuire, JM Lawrence, RJ Jakubowski, EM AF McGuire, Jeffrey M. Lawrence, Richard J. Jakubowski, Edward M., Jr. TI Enabling in vitro workflow for rapid identification of unique metabolic biomarkers from chemical warfare agent exposure SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [McGuire, Jeffrey M.; Lawrence, Richard J.; Jakubowski, Edward M., Jr.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM jeffrey.m.mcguire2.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 58-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475100191 ER PT J AU Orlicki, JA Escarsega, JA Rawlett, AM Leadore, JL Martin, GR Farrell, A Williams, AA Napadensky, E AF Orlicki, Joshua A. Escarsega, John A. Rawlett, Adam M. Leadore, Julia L. Martin, George R. Farrell, Alicia Williams, Andre' A. Napadensky, Eugene TI Biocidal coatings through self-segregating additives SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Orlicki, Joshua A.; Rawlett, Adam M.; Leadore, Julia L.; Martin, George R.; Williams, Andre' A.; Napadensky, Eugene] Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Escarsega, John A.; Farrell, Alicia] Army Res Lab, Coatings Corros & Engn Polymers Branch, Aberdeen Proving Ground, MD 21005 USA. EM joshua.a.orlicki.civ@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 551-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475103988 ER PT J AU Pendley, SS Hurley, MM Mannochi, A Baker, D Sumner, JJ Lundgren, C Bruce, BD AF Pendley, Scott S. Hurley, Margaret M. Mannochi, Amy Baker, David Sumner, James J. Lundgren, Cynthia Bruce, Barry D. TI Re-engineering Photosystem I as a photocatalytic hydrogen producing reactor SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Pendley, Scott S.; Hurley, Margaret M.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Mannochi, Amy; Baker, David; Sumner, James J.; Lundgren, Cynthia] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Bruce, Barry D.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA. EM scott.s.pendley.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 510-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475104679 ER PT J AU Poda, A AF Poda, Aimee TI Effect of photolysis on the stability of silver nanoparticles and their surface coatings in natural organic matrices SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Poda, Aimee] USA, Corps Engineers, Vicksburg, MS 39180 USA. EM aimee.r.poda@usace.army.mil RI Poda, Aimee/K-1905-2012 NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 171-COLL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475103625 ER PT J AU Potter, IK Hark, RR Tansi, BM Hilferding, K East, LJ Remus, JJ Harmon, RS Wise, MA AF Potter, Ian K. Hark, Richard R. Tansi, Benjamin M. Hilferding, Keith East, Lucille J. Remus, Jeremiah J. Harmon, Russel S. Wise, Michael A. TI Determination of the provenance of cassiterite ore concentrates using laser-induced breakdown spectroscopy (LIBS) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Potter, Ian K.; Hark, Richard R.; Tansi, Benjamin M.; Hilferding, Keith] Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA. [East, Lucille J.] Appl Spectra Inc, Fremont, CA 94538 USA. [Remus, Jeremiah J.] Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. [Harmon, Russel S.] USACE ERDC Int Res Off, London, England. [Wise, Michael A.] Smithsonian Inst, Div Mineral, Washington, DC 20560 USA. EM potteik08@juniata.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 38-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475100171 ER PT J AU Price, SC Jackson, AC Gold, CS Beyer, FL AF Price, Samuel C. Jackson, Aaron C. Gold, Chris S. Beyer, Frederick L. TI Phase separated, crosslinked anion exchange membranes for high performance fuel cells SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Price, Samuel C.; Jackson, Aaron C.; Gold, Chris S.; Beyer, Frederick L.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA. EM samuel.c.price7.ctr@mail.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 297-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503204547 ER PT J AU Roland, CD Kleine, TS Orlicki, JA Costanzo, PJ AF Roland, Chris D. Kleine, Tristan S. Orlicki, Joshua A. Costanzo, Philip J. TI Development of transparent, processable thermally-responsive coatings SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Roland, Chris D.; Kleine, Tristan S.; Costanzo, Philip J.] Calif Polytech State Univ San Luis Obispo, San Luis Obispo, CA 93407 USA. [Roland, Chris D.; Orlicki, Joshua A.] US Army Res Lab, RDRL WMM G, Aberdeen, MD 21005 USA. EM pcostanz@calpoly.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 60-POLY PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503204317 ER PT J AU Sadler, JM Toulan, FR Nguyen, APT La Scala, JJ AF Sadler, Joshua M. Toulan, Faye R. Nguyen, Anh-Phuong T. La Scala, John J. TI Development of bio-based resins from carbohydrate derived compounds for use in renewable composites SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Sadler, Joshua M.; Toulan, Faye R.; Nguyen, Anh-Phuong T.; La Scala, John J.] Army Res Lab, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA. EM joshua.sadler1@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 40-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475101363 ER PT J AU Sellers, MS Hurley, MM AF Sellers, Michael S. Hurley, Margaret M. TI XPairIt: A software toolkit for smart peptide reagent design SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Sellers, Michael S.; Hurley, Margaret M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM michael.s.sellers.ctr@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 280-COMP PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475104465 ER PT J AU Stanzione, JF Sadler, JM La Scala, JJ Wool, RP AF Stanzione, Joseph F. Sadler, Joshua M. La Scala, John J. Wool, Richard P. TI Lignin-derived monomers utilized in biobased resins SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Stanzione, Joseph F.; Wool, Richard P.] Univ Delaware, Dept Chem Engn, Newark, DC 19716 USA. [Sadler, Joshua M.; La Scala, John J.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jfstanz@udel.edu NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 226-CELL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475101543 ER PT J AU Swartz, A Riegner, D Butkus, M Labare, M AF Swartz, Amanda Riegner, Dawn Butkus, Michael Labare, Michael TI Effects of shortchain fatty acid on the release of dipocolinic acid from Bacillus anthracis endospores SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Swartz, Amanda; Riegner, Dawn; Labare, Michael] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Butkus, Michael] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. EM Amanda.Swartz@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 315-CHED PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475102030 ER PT J AU Tansi, BM Potter, IK East, LJ Remus, JJ Harmon, RS Wise, MS Hark, RR AF Tansi, Benjamin M. Potter, Ian K. East, Lucille J. Remus, Jeremiah J. Harmon, Russell S. Wise, Michael S. Hark, Richard R. TI Laser-induced breakdown spectroscopy (LIBS) for geochemical fingerprinting of columbite-tantalite sources SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Tansi, Benjamin M.; Potter, Ian K.; Hark, Richard R.] Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA. [East, Lucille J.] Appl Spectra Inc, Fremont, CA 94538 USA. [Remus, Jeremiah J.] Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. [Harmon, Russell S.] USACE ERDC, Int Res Off, London, England. [Wise, Michael S.] Smithsonian Inst, Div Mineral, Washington, DC 20013 USA. EM hark@juniata.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 40-ANYL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475100173 ER PT J AU Terrell, JL Wu, HC Tsao, CY Servinsky, MD Bentley, WE AF Terrell, Jessica L. Wu, Hsuan-Chen Tsao, Chen-Yu Servinsky, Matthew D. Bentley, William E. TI Cell surveillance of quorum sensing toward reporting the presence of contamination SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Terrell, Jessica L.; Wu, Hsuan-Chen; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Terrell, Jessica L.; Wu, Hsuan-Chen; Tsao, Chen-Yu; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA. [Servinsky, Matthew D.] US Army Res Lab, Sensors & Elect Devices Div, Adelphi, MD 20783 USA. EM jterrell@umd.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 167-BIOT PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475100702 ER PT J AU Williams, AA Labukas, J Orlicki, JA Escarsega, JA Placzankis, B AF Williams, Andre A. Labukas, Joseph Orlicki, Joshua A. Escarsega, John A. Placzankis, Brian TI Synthesis and application of rhodamine B and fluorescein dyes for early corrosion sensing SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 243rd National Spring Meeting of the American-Chemical-Society CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc C1 [Williams, Andre A.; Orlicki, Joshua A.] Army Res Lab, Macromol Sci & Technol Branch, Aberdeen Proving Ground, MD 21005 USA. [Labukas, Joseph; Escarsega, John A.; Placzankis, Brian] Army Res Lab, Coatings Corros & Engn Polymers Branch, Aberdeen Proving Ground, MD 21005 USA. EM andre.a.williams22.ctr@mail.mil NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 729-ORGN PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219JX UT WOS:000324503202920 ER PT J AU Zhang, SS Ren, XM Tran, DT Read, J AF Zhang, Sheng S. Ren, Xiaoming Tran, Dat T. Read, Jeffrey TI Catalytic effect of heat-treated iron and copper phthalocyanines in non-aqueous lithium/air batteries SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract CT 11th International Biorelated Polymer Symposium / 243rd National Spring Meeting of the American-Chemical-Society (ACS) CY MAR 25-29, 2012 CL San Diego, CA SP Amer Chem Soc, Div Polymer Chem Inc, Amer Chem Soc C1 [Zhang, Sheng S.; Ren, Xiaoming; Tran, Dat T.; Read, Jeffrey] US Army Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM shengshui.zhang@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 25 PY 2012 VL 243 MA 498-FUEL PG 1 WC Chemistry, Multidisciplinary SC Chemistry GA 219AH UT WOS:000324475105844 ER PT J AU Beine, H Anastasio, C Domine, F Douglas, T Barret, M France, J King, M Hall, S Ullmann, K AF Beine, Harry Anastasio, Cort Domine, Florent Douglas, Thomas Barret, Manuel France, James King, Martin Hall, Sam Ullmann, Kirk TI Soluble chromophores in marine snow, seawater, sea ice and frost flowers near Barrow, Alaska SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID DISSOLVED ORGANIC-MATTER; HYDROXYL RADICAL PHOTOPRODUCTION; HYDROGEN-PEROXIDE; NATURAL-WATERS; ARCTIC-OCEAN; SOUTH-POLE; PHOTOLYSIS; NITRATE; PHOTOCHEMISTRY; TEMPERATURE AB We measured light absorption in 42 marine snow, sea ice, seawater, brine, and frost flower samples collected during the OASIS field campaign between February 27 and April 15, 2009. Samples represented multiple sites between landfast ice and open pack ice in coastal areas approximately 5 km west of Barrow, Alaska. The chromophores that are most commonly measured in snow, H2O2, NO3-, and NO2-, on average account for less than 1% of sunlight absorption in our samples. Instead, light absorption is dominated by unidentified "residual" species, likely organic compounds. Light absorption coefficients for the frost flowers on first-year sea ice are, on average, 40 times larger than values for terrestrial snow samples at Barrow, suggesting very large rates of photochemical reactions in frost flowers. For our marine samples the calculated rates of sunlight absorption and OH production from known chromophores are (0.1-1.4) x 10(14) (photons cm(-3) s(-1)) and (5-70) x 10(-12) (mol L-1 s(-1)), respectively. Our residual spectra are similar to spectra of marine chromophoric dissolved organic matter (CDOM), suggesting that CDOM is the dominant chromophore in our samples. Based on our light absorption measurements we estimate dissolved organic carbon (DOC) concentrations in Barrow seawater and frost flowers as approximately 130 and 360 mu M C, respectively. We expect that CDOM is a major source of OH in our marine samples, and it is likely to have other significant photochemistry as well. C1 [Beine, Harry; Anastasio, Cort] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. [Domine, Florent; Barret, Manuel] Univ Grenoble 1, Lab Glaciol & Geophys Environm, CNRS INSU, F-38402 St Martin Dheres, France. [Douglas, Thomas] USA, Cold Reg Res & Engn Lab, Wainwright, AK 99703 USA. [France, James; King, Martin] Univ London, Dept Earth Sci, Egham TW20 0EX, Surrey, England. [Hall, Sam; Ullmann, Kirk] NCAR ACD, Boulder, CO 80301 USA. [Domine, Florent] Univ Laval, CNRS, Takuvik UMI 3376, Quebec City, PQ G1V 0A6, Canada. RP Beine, H (reprint author), Univ Calif Davis, Dept Land Air & Water Resources, 1 Shields Ave, Davis, CA 95616 USA. RI King, Martin/B-1308-2009; France, James/A-7885-2012; France, James/L-9719-2015 OI King, Martin/0000-0002-0089-7693; France, James/0000-0002-8785-1240 FU NSF [ATM-0807702]; French Polar Institute (IPEV) [1017]; U.S. National Science Foundation; National Aeronautic and Space Administration; U.S. Army Cold Regions Research and Engineering Laboratory; NERC [NE/F010788/1, NE/F004796/1]; NERC FSF [555.0608]; RHUL FX This work is part of the international multidisciplinary OASIS (Ocean-Atmosphere-Sea Ice-Snowpack) program. Funding for this work was gratefully received from NSF ATM-0807702. F.D. and M.B. were also funded by the French Polar Institute (IPEV grant 1017). T.D.'s research was supported by the U.S. National Science Foundation, the National Aeronautic and Space Administration, and the U.S. Army Cold Regions Research and Engineering Laboratory. J.L.F. and M.D.K. thank NERC for support through grants NE/F010788/1 and NE/F004796/1, NERC FSF for support through grant 555.0608 and the RHUL research strategy fund. We thank Tad Doane (UC Davis) for nitrate and nitrite analyses of our marine samples. NR 55 TC 17 Z9 17 U1 2 U2 31 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAR 23 PY 2012 VL 117 AR D00R15 DI 10.1029/2011JD016650 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 914IF UT WOS:000301942300001 ER PT J AU Landrum, ML Hullsiek, KH O'Connell, RJ Chun, HM Ganesan, A Okulicz, JF Lalani, T Weintrob, AC Crum-Cianflone, NF Agan, BK AF Landrum, Michael L. Hullsiek, Katherine Huppler O'Connell, Robert J. Chun, Helen M. Ganesan, Anuradha Okulicz, Jason F. Lalani, Tahaniyat Weintrob, Amy C. Crum-Cianflone, Nancy F. Agan, Brian K. CA HIV Working Grp TI Hepatitis B Vaccine Antibody Response and the Risk of Clinical AIDS or Death SO PLOS ONE LA English DT Article ID DELAYED-TYPE HYPERSENSITIVITY; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTED INDIVIDUALS; US MILITARY COHORT; T-CELL; REPLICATIVE SENESCENCE; ANTIRETROVIRAL THERAPY; CD4 COUNT; IN-VITRO; HAART AB Background: Whether seroresponse to a vaccine such as hepatitis B virus (HBV) vaccine can provide a measure of the functional immune status of HIV-infected persons is unknown. This study evaluated the relationship between HBV vaccine seroresponses and progression to clinical AIDS or death. Methods and Findings: From a large HIV cohort, we evaluated those who received HBV vaccine only after HIV diagnosis and had anti-HBs determination 1-12 months after the last vaccine dose. Non-response and positive response were defined as anti-HBs <10 and >= 10 IU/L, respectively. Participants were followed from date of last vaccination to clinical AIDS, death, or last visit. Univariate and multivariable risk of progression to clinical AIDS or death were evaluated with Cox regression models. A total of 795 participants vaccinated from 1986-2010 were included, of which 41% were responders. During 3,872 person-years of observation, 122 AIDS or death events occurred (53% after 1995). Twenty-two percent of non-responders experienced clinical AIDS or death compared with 5% of responders (p<0.001). Non-response to HBV vaccine was associated with a greater than 2-fold increased risk of clinical AIDS or death (HR 2.47; 95% CI, 1.38-4.43) compared with a positive response, after adjusting for CD4 count, HIV viral load, HAART use, and delayed type hypersensitivity skin test responses (an in vivo marker of cell-mediated immunity). This association remained evident among those with CD4 count >= 500 cells/mm(3) (HR 3.40; 95% CI, 1.39-8.32). Conclusions: HBV vaccine responses may have utility in assessing functional immune status and risk stratificating HIV-infected individuals, including those with CD4 count >= 500 cells/mm(3). C1 [Landrum, Michael L.; Hullsiek, Katherine Huppler; Ganesan, Anuradha; Lalani, Tahaniyat; Weintrob, Amy C.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Landrum, Michael L.; Okulicz, Jason F.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Hullsiek, Katherine Huppler] Univ Minnesota, Minneapolis, MN USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Chun, Helen M.; Crum-Cianflone, Nancy F.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Ganesan, Anuradha; Weintrob, Amy C.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Landrum, ML (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM mlandrum@idcrp.org OI Agan, Brian/0000-0002-5114-1669; Eberly, Lynn/0000-0003-4763-330X FU Department of Defense (DoD) [IDCRP-000-25]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement [Y1-AI-5072] FX Support for this work (IDCRP-000-25) was provided by the Infectious Disease Clinical Research Program (IDCRP, www.idcrp.org), a Department of Defense (DoD) program executed through Uniformed Services University of the Health Sciences. This project has been funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data, and provided salary support to investigators (M.L.L., A.G., T.L., A.C.W., and B.K.A.). The analyses, conclusions and decision to submit the manuscript are the independent work and decision of the authors. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH or the Department of Health and Human Services, the DoD or the Departments of the Army, Navy or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the U.S. Government. NR 43 TC 5 Z9 5 U1 0 U2 1 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAR 22 PY 2012 VL 7 IS 3 AR e33488 DI 10.1371/journal.pone.0033488 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 940QX UT WOS:000303909200032 PM 22457767 ER PT J AU Patzkowski, JC Blanck, RV Owens, JG Wilken, JM Kirk, KL Wenke, JC Hsu, JR AF Patzkowski, Jeanne C. Blanck, Ryan V. Owens, Johnny G. Wilken, Jason M. Kirk, Kevin L. Wenke, Joseph C. Hsu, Joseph R. CA Skeletal Trauma Res Consortium STR TI Comparative Effect of Orthosis Design on Functional Performance SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID PLANTARFLEXOR WEAKNESS; SPRING ORTHOSIS; GAIT ANALYSIS; FOOT; INJURIES; RECONSTRUCTION; AMPUTATIONS; DISABILITY; DISORDERS; CHILDREN AB Background: High-energy extremity trauma is common in combat. Orthotic options for patients whose lower extremities have been salvaged are limited. A custom energy-storing ankle-foot orthosis, the Intrepid Dynamic Exoskeletal Orthosis (IDEO), was created and used with high-intensity rehabilitation as part of the Return to Run clinical pathway. We hypothesized that the IDEO would improve functional performance compared with a non-custom carbon fiber orthosis (BlueRocker), a posterior leaf spring orthosis, and no brace. Methods: Eighteen subjects with unilateral dorsiflexion and/or plantar flexion weakness were evaluated with six functional tests while they were wearing the IDEO, BlueRocker, posterior leaf spring, or no brace. The brace order was randomized, and five trials were completed for each of the functional measures, which included a four-square step test, a sit-to-stand five times test, tests of self-selected walking velocity over level and rocky terrain, and a timed stair ascent. They also completed one trial of a forty-yard (37-m) dash, filled out a satisfaction questionnaire, and indicated whether they had ever considered an amputation and, if so, whether they still intended to proceed with it. Results: Performance was significantly better with the IDEO with respect to all functional measures compared with all other bracing conditions (p < 0.004), with the exception of the sit-to-stand five times test, in which there was a significant improvement only as compared with the BlueRocker (p = 0.014). The forty-yard dash improved by approximately 35% over the values for the posterior leaf spring and no-brace conditions, and by 28% over the BlueRocker. The BlueRocker demonstrated a significant improvement in the forty-yard dash compared with no brace (p = 0.033), and a significant improvement in self-selected walking velocity on level terrain compared with no brace and the posterior leaf spring orthosis (p < 0.028). However, no significant difference was found among the posterior leaf spring, BlueRocker, and no-brace conditions with respect to any other functional measure. Thirteen patients initially considered amputation, but after completion of the clinical pathway, eight desired limb salvage, two were undecided, and three still desired amputation. Conclusions: Use of the IDEO significantly improves performance on validated tests of agility, power, and speed. The majority of subjects initially considering amputation favored limb salvage after this noninvasive intervention. C1 [Patzkowski, Jeanne C.] San Antonio Mil Med Ctr, Orthopaed Surg Serv, Dept Orthopaed & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Patzkowski, JC (reprint author), San Antonio Mil Med Ctr, Orthopaed Surg Serv, Dept Orthopaed & Rehabil, Ctr Intrepid, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Jeanne.patzkowski2@amedd.army.mil OI Wilken, Jason/0000-0002-5556-7667 NR 31 TC 33 Z9 33 U1 2 U2 20 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAR 21 PY 2012 VL 94A IS 6 BP 507 EP 515 DI 10.2106/JBJS.K.00254 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 913PA UT WOS:000301888700005 PM 22437999 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Spin flip probability of electron in a uniform magnetic field SO APPLIED PHYSICS LETTERS LA English DT Article DE electromagnetic pulse; electron spin; quantum statistical mechanics AB The probability that an electromagnetic wave can flip the spin of an electron is calculated. It is assumed that the electron resides in a uniform magnetic field and interacts with an incoming electromagnetic pulse. The scattering matrix is constructed and the time needed to flip the spin is calculated. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3691937] C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. [Hammond, Richard T.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. EM rhammond@email.unc.edu NR 13 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 19 PY 2012 VL 100 IS 12 AR 121112 DI 10.1063/1.3691937 PG 4 WC Physics, Applied SC Physics GA 918DE UT WOS:000302228700012 ER PT J AU Gauer, RL Braun, MM AF Gauer, Robert L. Braun, Michael M. TI Thrombocytopenia SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID HEPARIN-INDUCED THROMBOCYTOPENIA; INDUCED IMMUNE THROMBOCYTOPENIA; PLATELET COUNT; PURPURA; MANAGEMENT; DIAGNOSIS; RISK; PSEUDOTHROMBOCYTOPENIA; GUIDELINES; ANTIBODIES AB Thrombocytopenia is defined as a platelet count of less than 150 X 10(3) per mu L. It is often discovered incidentally when obtaining a complete blood count during an office visit. The etiology usually is not obvious, and additional investigation is required. Patients with platelet counts greater than 50 X 10(3) per mu L rarely have symptoms. A platelet count from 30 to 50 X 10(3) per mu L, rarely manifests as purpura. A count from 10 to 30 X 10(3) per mu L may cause bleeding with minimal trauma. A platelet count less than 5 X 10(3) per mu L may cause spontaneous bleeding and constitutes a hematologic emergency. Patients who present with thrombocytopenia as part of a multisystem disorder usually are ill and require urgent evaluation and treatment. These patients most likely have an acute infection, heparin-induced thrombocytopenia, liver disease, thrombotic thrombocytopenic purpura/hemolytic uremic syndrome, disseminated intravascular coagulation, or a hematologic disorder. During pregnancy, preeclampsia and the HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome are associated with thrombocytopenia. Patients with isolated thrombocytopenia commonly have drug-induced thrombocytopenia, immune thrombocytopenic purpura, pseudothrombocytopenia, or if pregnant, gestational thrombocytopenia. A history, physical examination, and laboratory studies can differentiate patients who require immediate intervention from those who can be treated in the outpatient setting. Treatment is based on the etiology and, in some cases, treating the secondary cause results in normalization of platelet counts. Consultation with a hematologist should be considered if patients require hospitalization, if there is evidence of systemic disease, or if thrombocytopenia worsens despite initial treatment. (Am Fam Physician. 2012;85 (6):612-622. Copyright (C) 2012 American Academy of Family Physicians.) C1 [Gauer, Robert L.] Womack Army Med Ctr Family Med Residency, Ft Bragg, NC USA. [Braun, Michael M.] 1st Special Forces Grp, Ft Lewis, WA USA. RP Gauer, RL (reprint author), Womack Army Med Ctr, Bldg 4-2817,Riley Rd, Ft Bragg, NC 28310 USA. EM Robert.gauer@us.army.mil NR 42 TC 10 Z9 10 U1 1 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 15 PY 2012 VL 85 IS 6 BP 612 EP 622 PG 11 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980BD UT WOS:000306867700009 PM 22534274 ER PT J AU Fargo, MV Latimer, KM AF Fargo, Matthew V. Latimer, Kelly M. TI Evaluation and Management of Common Anorectal Conditions SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CHRONIC ANAL-FISSURE; PROCTALGIA-FUGAX; FECAL INCONTINENCE; COLORECTAL-CANCER; PRURITUS ANI; SYMPTOMS; FISTULA; CARE; HEMORRHOIDECTOMY; NITROGLYCERIN AB The prevalence of benign anorectal conditions in the primary care setting is high, although evidence of effective therapy is often lacking. In addition to recognizing common benign anorectal disorders, physicians must maintain a high index of suspicion for inflammatory and malignant disorders. Patients with red flags such as increased age, family history, persistent anorectal bleeding despite treatment, weight loss, or iron deficiency anemia should undergo colonoscopy. Pruritus ani, or perianal itching, is managed by treating the underlying cause, ensuring proper hygiene, and providing symptomatic relief with oral antihistamines, topical steroids, or topical capsaicin. Effective treatments for anal fissures include onabotulinumtoxinA, topical nitroglycerin, and topical calcium channel blockers. Symptomatic external hemorrhoids are managed with dietary modifications, topical steroids, and analgesics. Thrombosed hemorrhoids are best treated with hemorrhoidectomy if symptoms are present for less than 72 hours. Grades I through III internal hemorrhoids can be managed with rubber band ligation. For the treatment of grade III internal hemorrhoids, surgical hemorrhoidectomy has higher remission rates but increased pain and complication rates compared with rubber band ligation. Anorectal condylomas, or anogenital warts, are treated based on size and location, with office treatment consisting of topical trichloroacetic acid or podophyllin, cryotherapy, or laser treatment. Simple anorectal fistulas can be treated conservatively with sitz baths and analgesics, whereas complex or nonhealing fistulas may require surgery. Fecal impaction may be treated with polyethylene glycol, enemas, or manual disimpaction. Fecal incontinence is generally treated with loperamide and biofeedback. Surgical intervention is reserved for anal sphincter injury. (Am Fam Physician. 2012;85 (6):624-630. Copyright (C) 2012 American Academy of Family Physicians.) C1 [Fargo, Matthew V.] Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA 30905 USA. RP Fargo, MV (reprint author), Eisenhower Army Med Ctr, Dept Family Med, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM matthew.fargo@us.army.mil NR 43 TC 8 Z9 9 U1 0 U2 9 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAR 15 PY 2012 VL 85 IS 6 BP 624 EP 630 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980BD UT WOS:000306867700010 PM 22534276 ER PT J AU Casem, DT Dandekar, DP AF Casem, Daniel T. Dandekar, Dattatraya P. TI Shock and mechanical response of 2139-T8 aluminum SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INTERFEROMETER; DISPLACEMENT; STRENGTH; IMPACT AB Planar shock wave experiments were performed on 2139-T8 aluminum to determine its response to dynamic loading. A Hugoniot was determined to 12 GPa. Lateral stress measurements along with a study of the release behavior indicate that this material retains its shear strength to at least 8 GPa. Spall strength was measured for similar to 1 mu s compressive pulse durations and found to be approximately constant at 1.45 GPa up to shock stresses of 10 GPa. Beyond 10 GPa, spall strength decreases considerably. Uniaxial stress compression tests were conducted with a servo-hydraulic load frame and the Kolsky bar method to obtain stress-strain curves at strain-rates from 0.001/s to 85k/s. This data shows the material is rate independent. The shock experiments were simulated using a Lagrangian finite element code using a polynomial equation of state, the Johnson-Cook strength law, and the Cochran and Banner spall model. The ability of the simulations to reproduce the experimentally measured data is mixed, with significant deviations in modeling the plastic wave front, plastic release, and the spall pull-back signals. [http://dx.doi.org/10.1063/1.3694661] C1 [Casem, Daniel T.; Dandekar, Dattatraya P.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Casem, DT (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM daniel.t.casem.civ@mail.mil NR 29 TC 3 Z9 3 U1 0 U2 17 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2012 VL 111 IS 6 AR 063508 DI 10.1063/1.3694661 PG 12 WC Physics, Applied SC Physics GA 918AR UT WOS:000302221700025 ER PT J AU Clayton, JD Becker, R AF Clayton, J. D. Becker, R. TI Elastic-plastic behavior of cyclotrimethylene trinitramine single crystals under spherical indentation: Modeling and simulation SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PENTAERYTHRITOL TETRANITRATE; RDX; NANOINDENTATION; CONSTANTS; SAPPHIRE; DEFECT; SLIP AB A nonlinear anisotropic elastic-plastic model is developed for single crystals of the energetic material cyclotrimethylene trinitramine (RDX). Numerical simulations of spherical indentation on oriented single crystals are performed; predictions are compared with experimental data and observations from the literature. Model predictions for elastic response and initial yield using elastic constants obtained from resonant ultrasound spectroscopy agree with experimental data; predicted forces using constants obtained from Brillouin scattering tend to exceed experimental data. Influences of elastic anisotropy and elastic nonlinearity are significant. Predicted slip system activity is in reasonable agreement with that deduced from experimental surface profiles when a uniform strength of G/20 is assigned to all six slip systems, with G an effective elastic shear modulus. Predicted indentation forces in the post-yield regime exceed those observed in experiments, suggesting that surface and possibly subsurface fractures may contribute to a loss of stiffness in experiments at larger indentation depths. [http://dx.doi.org/10.1063/1.3695392] C1 [Clayton, J. D.; Becker, R.] USA, Res Lab, Impact Phys RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Impact Phys RDRL WMP C, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1.civ@mail.mil RI Clayton, John/C-7760-2009; Becker, Richard/I-1196-2013 NR 28 TC 18 Z9 18 U1 0 U2 17 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2012 VL 111 IS 6 AR 063512 DI 10.1063/1.3695392 PG 9 WC Physics, Applied SC Physics GA 918AR UT WOS:000302221700029 ER PT J AU Ghosh, D Subhash, G Zheng, JQ Halls, V AF Ghosh, Dipankar Subhash, Ghatu Zheng, James Q. Halls, Virginia TI Influence of stress state and strain rate on structural amorphization in boron carbide SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DYNAMIC INDENTATION RESPONSE; MECHANICAL-PROPERTIES; UNIAXIAL COMPRESSION; BRITTLE MATERIALS; CERAMICS; PLASTICITY; STRENGTH; BEHAVIOR; FAILURE; SHOCK AB The reduced performance of B4C armor plate for impact against tungsten carbide penetrators beyond a critical velocity has been attributed in the literature to localized amorphization. However, it is unclear if this reduction in strength is a consequence of high pressure or high velocity. Despite numerous fundamental studies of B4C under indentation and impact, the roles of strain rate and pressure on amorphization have not been fully established. Toward this end, rate dependent uniaxial compressive strength and rate dependent indentation hardness, along with Raman spectroscopy, have been employed to show that high strain rate deformation alone (without concurrent high pressure) cannot trigger localized amorphization in B4C. Based on our analysis, it is also suggested that rate dependent indentation hardness can be used to reveal if a given B4C ceramic exhibits amorphization under high pressure and high strain rate loading. It is argued that when amorphization does occur in B4C, its dynamic inelastic properties degrade more severely than its static properties. Finally, it is suggested that dynamic hardness, in conjunction with static hardness, can be used as a measurable mechanical property to reveal the incidence of amorphization in B4C without the need for postmortem TEM or Raman spectroscopy analyses. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3696971] C1 [Subhash, Ghatu] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. [Ghosh, Dipankar] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Zheng, James Q.; Halls, Virginia] USA, Program Execut Off Soldier, Haymarket, VA 20169 USA. RP Subhash, G (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. EM subhash@ufl.edu NR 36 TC 14 Z9 14 U1 7 U2 42 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2012 VL 111 IS 6 AR 063523 DI 10.1063/1.3696971 PG 9 WC Physics, Applied SC Physics GA 918AR UT WOS:000302221700040 ER PT J AU Younes, H Christensen, G Luan, XN Hong, HP Smith, P AF Younes, Hammad Christensen, Greg Luan, Xinning Hong, Haiping Smith, Pauline TI Effects of alignment, pH, surfactant, and solvent on heat transfer nanofluids containing Fe2O3 and CuO nanoparticles SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ENHANCED THERMAL-CONDUCTIVITY; FE NANOFLUIDS; SUSPENSIONS; NANOTUBE AB In this paper, the effects of alignment, pH, surfactant and solvent on heat transfer nanofluids containing Fe2O3 and CuO nanoparticles are studied and analyzed. The microscope images show that Fe2O3 could form some kind of alignment spontaneously in water even without external magnetic field. With the addition of external magnetic field, the alignment is strengthened. In water, the magnetic particle agglomeration to larger size occurs easily, which makes the directional alignment much faster and easier. Ethylene glycol solvent and chemical surfactant sodium dodecyl benzene sulfonate, NaDDBS could separate the Fe2O3 and CuO nanoparticles well in the fluids and avoid possible aggregation. Therefore, magnetic alignments are hard to observe. The measured thermal conductivities of each individual sample coincide with the microscope images and assumptions. In addition, pH values of Fe2O3 and CuO nanoparticles are measured and it has been determined that at those pH values, thermal conductivities of those nanoparticles would not be influenced according to the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. The highlight of this paper is that our microscope images could well explain most of the literature data and conclusions and may open new door to better understanding fundamental nature of nanofluids. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3694676] C1 [Younes, Hammad; Christensen, Greg; Luan, Xinning; Hong, Haiping] S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. [Smith, Pauline] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Younes, H (reprint author), S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. EM haiping.hong@sdsmt.edu RI Luan, Xinning/A-8129-2016 OI Luan, Xinning/0000-0003-4513-8962 FU Army Research Laboratory [W911NF-08-2-0022]; NASA EPSCoR [NNX09AU83 A] FX The financial support of Army Research Laboratory (Cooperative agreement W911NF-08-2-0022) and NASA EPSCoR (award No. NNX09AU83 A) are acknowledged. The authors would like to thank Sungho Jin, Department of Mechanical & Aerospace Engineering, University of California San Diego and Edward Duke, Department of Geology and Geological Engineering, SD School of Mines and Technology, for their stimulating comments. Also thank Carine Tchamakam Wamkam of Material and Metallurgical Engineering Department, SD School of Mines for measuring the zeta potential and particle size distribution of nanoparticles. NR 26 TC 30 Z9 31 U1 0 U2 21 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 15 PY 2012 VL 111 IS 6 AR 064308 DI 10.1063/1.3694676 PG 7 WC Physics, Applied SC Physics GA 918AR UT WOS:000302221700112 ER PT J AU Yeh, IC Ripoll, DR Wallqvist, A AF Yeh, In-Chul Ripoll, Daniel R. Wallqvist, Anders TI Free Energy Difference in Indolicidin Attraction to Eukaryotic and Prokaryotic Model Cell Membranes SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; ATOMIC-FORCE MICROSCOPY; ANTIMICROBIAL PEPTIDE INDOLICIDIN; QUARTZ-CRYSTAL MICROBALANCE; HISTOGRAM ANALYSIS METHOD; LIPID-BILAYERS; WATER; ANTIBIOTICS; MECHANISMS; TRYPTOPHAN AB We analyzed the thermodynamic and structural determinants of indolicidin interactions with eukaryotic and prokaryotic cell membranes using a series of atomistically detailed molecular dynamics simulations. We used quartz-supported bilayers with two different compositions of zwitterionic and anionic phospholipids as model eukaryotic and prokaryotic cell membranes. Indolicidin was preferentially attracted to the model prokaryotic cell membrane in contrast to the weak adsorption on the eukaryotic membrane. The nature of the indolicidin surface adsorption depended on an electrostatic guiding component, an attractive enthalpic component derived from van der Waals interactions, and a balance between entropic factors related to peptide confinement at the interface and counterion release from the bilayer surface. Thus, whereas we attributed the specificity of the indolicidin/membrane interaction to electrostatics, these interactions were not the sole contributors to the free energy of adsorption. Instead, a balance between an attractive van der Waals enthalpic component and a repulsive entropic component determined the overall strength of indolicidin adsorption. C1 [Yeh, In-Chul; Ripoll, Daniel R.; Wallqvist, Anders] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. RP Yeh, IC (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA. EM icy@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 FU competitive In-house Laboratory Independent Research (ILIR); U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT); Department of Defense (DoD) High Performance Computing (HPC) Modernization Office under the HPC Software Applications Institute initiative; U.S. Army Medical Research and Materiel Command FX This project was funded in part by a competitive In-house Laboratory Independent Research (ILIR) grant by the U.S. Army Assistant Secretary of the Army for Acquisition, Logistics, and Technology (ASAALT). Funding support for this work also came from the Department of Defense (DoD) High Performance Computing (HPC) Modernization Program Office, under the HPC Software Applications Institute initiative, the U.S. Army Medical Research and Materiel Command. Computational time was provided by the U.S. Army Research Laboratory, U.S. Army Engineer Research and Development Center, and Navy DoD Supercomputing Resource Centers. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. NR 51 TC 7 Z9 7 U1 1 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD MAR 15 PY 2012 VL 116 IS 10 BP 3387 EP 3396 DI 10.1021/jp211883u PG 10 WC Chemistry, Physical SC Chemistry GA 908SC UT WOS:000301509500036 PM 22376120 ER PT J AU Schultz, MK Wright, LKM Stone, MF Schwartz, JE Kelley, NR Moffett, MC Lee, RB Lumley, LA AF Schultz, M. K. Wright, L. K. M. Stone, M. F. Schwartz, J. E. Kelley, N. R. Moffett, M. C. Lee, R. B. Lumley, L. A. TI The anticholinergic and antiglutamatergic drug caramiphen reduces seizure duration in soman-exposed rats: Synergism with the benzodiazepine diazepam SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Soman; Caramiphen; Diazepam; Physostigmine; Seizure; Neuroprotection ID HIPPOCAMPAL PYRAMIDAL NEURONS; INDUCED BRAIN-DAMAGE; SIGMA-SITE LIGANDS; STATUS EPILEPTICUS; NONOPIOID ANTITUSSIVES; MEDICAL COUNTERMEASURES; COGNITIVE DYSFUNCTION; RECEPTOR TRAFFICKING; RECURRENT SEIZURES; GABA(A) RECEPTORS AB Therapy of seizure activity following exposure to the nerve agent soman (GD) includes treatment with the anticonvulsant diazepam (DZP), an allosteric modulator of gamma-aminobutyric acid A (GABA(A)) receptors. However, seizure activity itself causes the endocytosis of GABA(A) receptors and diminishes the inhibitory effects of GABA, thereby reducing the efficacy of DZP. Treatment with an N-methyl-D-aspartic acid (NMDA) receptor antagonist prevents this reduction in GABAergic inhibition. We examined the efficacy of the NMDA receptor antagonist caramiphen edisylate (CED: 20 mg/kg, im) and DZP (10 mg/kg, sc), administered both separately and in combination, at 10, 20 or 30 min following seizure onset for attenuation of the deleterious effects associated with GD exposure (1.2 LD50; 132 mu g/kg, sc) in rats. Outcomes evaluated were seizure duration, neuropathology, acetylcholinesterase (AChE) activity, body weight, and temperature. We also examined the use of the reversible AChE inhibitor physostigmine (PHY; 0.2 mg/kg, im) as a therapy for GD exposure. We found that the combination of CED and DZP yielded a synergistic effect, shortening seizure durations and reducing neuropathology compared to DZP alone, when treatment was delayed 20-30 min after seizure onset. PHY reduced the number of animals that developed seizures, protected a fraction of AChE from GD inhibition, and attenuated post-exposure body weight and temperature loss independent of CED and/or DZP treatment We conclude that: 1) CED and DZP treatment offers considerable protection against the effects of GD and 2) PHY is a potential therapeutic option following GD exposure, albeit with a limited window of opportunity. Published by Elsevier Inc. C1 [Schultz, M. K.; Wright, L. K. M.; Stone, M. F.; Schwartz, J. E.; Kelley, N. R.; Moffett, M. C.; Lee, R. B.; Lumley, L. A.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Lumley, LA (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM lucille.a.lange@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office; Medical ST Division; Physical Science Division; U.S. Army Medical Research Institute of Chemical Defense FX This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division and Physical Science Division (PI: Dr. Lucille Lumley). Mark Schultz and Dr. Linnzi Wright were supported by appointments to the Student/Postdoctoral Research Participation Program at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency appointment between the U.S. Department of Energy and USAMRMC. NR 59 TC 6 Z9 7 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD MAR 15 PY 2012 VL 259 IS 3 BP 376 EP 386 DI 10.1016/j.taap.2012.01.017 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 913QP UT WOS:000301892800013 PM 22310180 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Steinbeck in Vietnam: Dispatches from the War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 2012 VL 137 IS 5 BP 110 EP 110 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 911AY UT WOS:000301690900076 ER PT J AU Xin, QC Woodcock, CE Liu, JC Tan, B Melloh, RA Davis, RE AF Xin, Qinchuan Woodcock, Curtis E. Liu, Jicheng Tan, Bin Melloh, Rae A. Davis, Robert E. TI View angle effects on MODIS snow mapping in forests SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Remote sensing; MODIS; Snow cover; View angle effect ID BIDIRECTIONAL REFLECTANCE; OPTICAL-PROPERTIES; GAP FRACTIONS; COVER; MODEL; RESOLUTION; CANOPIES; ALBEDO; VALIDATION AB Binary snow maps and fractional snow cover data are provided routinely from MODIS (Moderate Resolution Imaging Spectroradiometer). This paper investigates how the wide observation angles of MODIS influence the current snow mapping algorithm in forested areas. Theoretical modeling results indicate that large view zenith angles (VZA) can lead to underestimation of fractional snow cover (FSC) by reducing the amount of the ground surface that is viewable through forest canopies, and by increasing uncertainties during the gridding of MODIS data. At the end of the MODIS scan line, the total modeled error can be as much as 50% for FSC. Empirical analysis of MODIS/Terra snow products in four forest sites shows high fluctuation in FSC estimates on consecutive days. In addition, the normalized difference snow index (NDSI) values, which are the primary input to the MODIS snow mapping algorithms, decrease as VZA increases at the site level. At the pixel level. NDSI values have higher variances, and are correlated with the normalized difference vegetation index (NDVI) in snow covered forests. These findings are consistent with our modeled results, and imply that consideration of view angle effects could improve MODIS snow monitoring in forested areas. (C) 2011 Elsevier Inc. All rights reserved. C1 [Xin, Qinchuan; Woodcock, Curtis E.] Boston Univ, Dept Geog & Environm, Boston, MA 02215 USA. [Liu, Jicheng] NOAA NESDIS STAR, IM Syst Grp, Rockville, MD 20852 USA. [Tan, Bin] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20770 USA. [Melloh, Rae A.; Davis, Robert E.] Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Xin, QC (reprint author), Boston Univ, Dept Geog & Environm, 675 Commonwealth Ave,Room 334, Boston, MA 02215 USA. EM xqcchina@gmail.com RI Tan, Bin/G-1331-2012; Liu, Jicheng/B-4575-2009; Xin, Qinchuan/O-3276-2014 OI Xin, Qinchuan/0000-0003-1146-4874 NR 29 TC 19 Z9 20 U1 0 U2 27 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD MAR 15 PY 2012 VL 118 BP 50 EP 59 DI 10.1016/j.rse.2011.10.029 PG 10 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 895SW UT WOS:000300517700005 ER PT J AU Sun, L Guo, JS Zhou, J Xu, QM Chu, D Chen, RR AF Sun, Lu Guo, Junsong Zhou, Jie Xu, Qingming Chu, Deryn Chen, Rongrong TI Novel nanostructured high-performance anion exchange ionomers for anion exchange membrane fuel cells SO JOURNAL OF POWER SOURCES LA English DT Article DE Ionomer; Block copolymers; Self-assembly; Quaternary ammonium; Anion-exchange-membrane fuel cells ID ALKALINE POLYMER ELECTROLYTE; CONDUCTIVITY; COPOLYMERS; MORPHOLOGY; CATALYST AB A novel block copolymer, styrene-ethylene/butylene-styrene (SEBS), was chosen as the starting material to prepare pendant quaternary ammonium-based ionomers with an ion-exchange-capacity (IEC) of 0.66, 1.30, and 1.54 mequiv.g(-1), denoted by QSEBS-L, QSEBS-M, and QSEBS-H, respectively. These QSEBS ionomers have been demonstrated to have excellent dimensional stability against hydration without significantly sacrificing the ionic conductivity as compared to the widely studied polysulfone (PSf-based ionomers. The water uptake of the QSEBS-based ionomers depended on their functionality: a higher IEC in the ionomer resulted in more water uptake and a higher ionic conductivity. The MEAs fabricated with the QSEBS-M and QSEBS-H ionomers showed the best H-2/O-2 fuel cell performance with peak power densities reaching 210 mW cm(-2) at 50 degrees C, which was significantly higher than that of the PSf-based ionomers (similar to 30 mW cm(-2)). Electrochemical impedance spectroscopy (EIS) analysis indicated that the superior fuel cell performance observed with the QSEBS-based ionomers can be attributed to: (1) the low internal cell resistance, and (2) the low charge transfer resistance in both the anode and the cathode due to the excellent dimensional stability and the balanced conductivity-hydrophobicity originated by the unique morphology of the QSEBS-based ionomers. AFM phase imaging measurements of the QSEBS-based ionomers revealed unique nanostructures containing isolated hydrophobic and continuous anion conducting hydrophilic domains. By further optimizing the chemistry and morphology of the ionomers and the membranes, the resistance of the anode and cathode of the AEMFCs will be further reduced. The performance of anion-exchange-membrane fuel cells will be further improved. (C) 2011 Elsevier B.V. All rights reserved. C1 [Sun, Lu; Guo, Junsong; Zhou, Jie; Xu, Qingming; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, RR (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. EM rochen@iupui.edu FU Army Research Laboratory [W911NF-10-2-0075] FX This work was sponsored by the Army Research Laboratory (Grant no. W911NF-10-2-0075). The Kraton G SEBS A1535 H sample was kindly provided by Kraton Performance Polymers, Inc. NR 23 TC 33 Z9 33 U1 5 U2 76 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2012 VL 202 BP 70 EP 77 DI 10.1016/j.jpowsour.2011.11.023 PG 8 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 890IU UT WOS:000300139100009 ER PT J AU Crowther, O Keeny, D Moureau, DM Meyer, B Salomon, M Hendrickson, M AF Crowther, Owen Keeny, Daniel Moureau, David M. Meyer, Benjamin Salomon, Mark Hendrickson, Mary TI Electrolyte optimization for the primary lithium metal air battery using an oxygen selective membrane SO JOURNAL OF POWER SOURCES LA English DT Article DE Primary Li-air battery; Oxygen selective membrane; Electrolyte optimization; Ambient discharge ID NONAQUEOUS ELECTROLYTES; CARBONATE ELECTROLYTES; LI/AIR BATTERIES; PERFORMANCE; OPERATION AB The electrolyte solution for a primary nonaqueous lithium metal air battery is optimized. A novel oxygen selective membrane consisting of Teflon coated fiberglass cloth is used to prevent corrosion of the lithium metal negative electrode by water vapor during discharge in ambient air. The air electrode capacity is increased by increasing the amount of dimethyl carbonate and methoxybenzene in the electrolyte solvent, increasing the lithium tetrafluoroborate concentration to 1.5 M, and adding 4 mass % pentafluorophenylboron oxalate. Cells using either the starting or optimized electrolyte were discharged at a current density of 0.1 mA cm(-2) in air at 23 degrees C and 20% relative humidity. The discharge capacity (averaged for five discharges using each electrolyte solution) was increased by a factor of 2.2 for the cells using the optimized electrolyte solution of 1.5 M lithium tetrafluoroborate in propylene carbonate:dimethyl carbonate:methoxybenzene (1:5:1 by volume) + 4 mass % pentafluorophenylboron oxalate. (C) 2011 Elsevier By. All rights reserved. C1 [Crowther, Owen; Keeny, Daniel; Moureau, David M.; Meyer, Benjamin; Salomon, Mark] MaxPower Inc, Harleysville, PA 19438 USA. [Hendrickson, Mary] USA, RDECOM CERDEC C2D, Army Power Div, RDER CCA, Aberdeen Proving Ground, MD 21005 USA. RP Crowther, O (reprint author), MaxPower Inc, 141 Christopher Lane, Harleysville, PA 19438 USA. EM Owen.Crowther@MaxPowerInc.com RI Amir, Shahizat/B-5383-2010 FU US Army [W15P7T-09-C-S330, W15P7T-10-C-H602] FX We would like to acknowledge the US Army for funding this research and development under contracts W15P7T-09-C-S330 and W15P7T-10-C-H602. NR 26 TC 35 Z9 35 U1 9 U2 75 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD MAR 15 PY 2012 VL 202 BP 347 EP 351 DI 10.1016/j.jpowsour.2011.11.024 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 890IU UT WOS:000300139100046 ER PT J AU Jacobi, HW Voisin, D Jaffrezo, JL Cozic, J Douglas, TA AF Jacobi, H. W. Voisin, D. Jaffrezo, J. L. Cozic, J. Douglas, T. A. TI Chemical composition of the snowpack during the OASIS spring campaign 2009 at Barrow, Alaska SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SEA-SALT AEROSOL; FROST FLOWERS; ARCTIC HAZE; ICE; CHEMISTRY; MERCURY; REGIONS; DEPOSITION; TRANSPORT; HALOGENS AB The chemical composition of the seasonal snowpack was determined close to Barrow, an Arctic coastal location in northern Alaska. One hundred and twelve samples of different snow types including fresh snow, surface hoar, diamond dust, blowing snow, rounded snow grains, and depth hoar were collected and analyzed for major sea salt components, bromide, and nitrate. Sodium, chloride, sulfate, and potassium are mainly introduced into the snowpack by the deposition of sea salt, while magnesium and calcium result from a combination of sea salt and dust. Sulfate was strongly depleted in most samples compared to other sea salt components. This is attributed to the precipitation of mirabilite in newly formed sea ice and frost flowers that leads to an efficient fractionation of sulfate. Uptake of volatile but soluble species from the gas phase also contributed to the observed chloride, sulfate, and nitrate in the snow. However, for chloride and sulfate the input from the marine sources was overwhelming and the uptake from the gas phase was only visible in the samples with low concentrations like fresh snow, diamond dust, and surface hoar. Nitrate concentrations in the snowpack were less variable and for aged snow nitrate was related to the specific surface area of the snow indicating the adsorption of nitric acid can be an important nitrate source in the aged snow. Bromide was also introduced into the snowpack from marine sources, but due to its high reactivity it was partly transferred back to the atmosphere in the form of reactive species. The result of these processes was evident in bromide concentrations, which were both enriched and depleted at the snowpack surface while deeper layers were mostly depleted. Blowing snow also exhibited a depleted bromide composition. For all compounds except nitrate, many depth hoar samples exhibited the greatest concentrations, probably as a result of higher input earlier in the season as well as increases due to the sublimation of water during the metamorphism of the snow. C1 [Jacobi, H. W.; Voisin, D.; Jaffrezo, J. L.; Cozic, J.] Univ Grenoble 1, CNRS, Lab Glaciol & Geophys Environm, UMR 5183, Grenoble, France. [Douglas, T. A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. RP Jacobi, HW (reprint author), Univ Grenoble 1, CNRS, Lab Glaciol & Geophys Environm, UMR 5183, Grenoble, France. EM jacobi@lgge.obs.ujf-grenoble.fr RI voisin, didier/F-9911-2010 OI voisin, didier/0000-0003-1317-7561 FU French Polar Institute (IPEV) [1017]; INSU-CNRS; U.S. National Science Foundation [NSF ATM-0807702] FX This work is part of the international multidisciplinary OASIS (Ocean-Atmosphere-Sea Ice-Snowpack) program. It was supported by the French Polar Institute (IPEV) through grant 1017, by the LEFE-CHAT program of INSU-CNRS, and by the U.S. National Science Foundation through grant NSF ATM-0807702. The Barrow Arctic Science Consortium is acknowledged for providing logistical support in the Barrow area. NR 47 TC 11 Z9 11 U1 73 U2 115 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAR 14 PY 2012 VL 117 AR D00R13 DI 10.1029/2011JD016654 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 910VJ UT WOS:000301670900006 ER PT J AU Moran, DS Heled, Y Arbel, Y Israeli, E Finestone, AS Evans, RK Yanovich, R AF Moran, Daniel S. Heled, Yuval Arbel, Yael Israeli, Eran Finestone, Aharon S. Evans, Rachel K. Yanovich, Ran TI Dietary intake and stress fractures among elite male combat recruits SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Article DE Basic training; Bone; Calcium; Vitamin D; Nutrition ID FEMALE MILITARY RECRUITS; RISK-FACTORS; FOOD FREQUENCY; BONE TURNOVER; ARMY; VITAMIN; REQUIREMENTS; ASSOCIATION; NUTRITION; CALCIUM AB Background: Appropriate and sufficient dietary intake is one of the main requirements for maintaining fitness and health. Inadequate energy intake may have a negative impact on physical performance which may result in injuries among physically active populations. The purpose of this research was to evaluate a possible relationship between dietary intake and stress fracture occurrence among combat recruits during basic training (BT). Methods: Data was collected from 74 combat recruits (18.2 +/- 0.6 yrs) in the Israeli Defense Forces. Data analyses included changes in anthropometric measures, dietary intake, blood iron and calcium levels. Measurements were taken on entry to 4-month BT and at the end of BT. The occurrence of stress reaction injury was followed prospectively during the entire 6-month training period. Results: Twelve recruits were diagnosed with stress fracture in the tibia or femur (SF group). Sixty two recruits completed BT without stress fractures (NSF). Calcium and vitamin D intakes reported on induction day were lower in the SF group compared to the NSF group-38.9% for calcium (589 +/- 92 and 964 +/- 373 mg.d(-1), respectively, p < 0.001), and -25.1% for vitamin D (117.9 +/- 34.3 and 157.4 +/- 93.3 IU.d(-1), respectively, p < 0.001). During BT calcium and vitamin D intake continued to be at the same low values for the SF group but decreased for the NSF group and no significant differences were found between these two groups. Conclusions: The development of stress fractures in young recruits during combat BT was associated with dietary deficiency before induction and during BT of mainly vitamin D and calcium. For the purpose of intervention, the fact that the main deficiency is before induction will need special consideration. C1 [Moran, Daniel S.; Heled, Yuval; Arbel, Yael; Finestone, Aharon S.; Yanovich, Ran] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Moran, Daniel S.] Ariel Univ, Ctr Samaria, Ariel, Israel. [Israeli, Eran] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Gastroenterol, Div Med, Jerusalem, Israel. [Finestone, Aharon S.] Tel Aviv Univ, Dept Orthopaed, Assaf Harofeh Med Ctr, Zerifin & Sackler Sch Med, IL-69978 Tel Aviv, Israel. [Evans, Rachel K.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA USA. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il OI Finestone, Aharon/0000-0003-1956-5557 FU MRMC [W911QY-08-P-0286] FX This study was supported in part by a contract from the MRMC (No. W911QY-08-P-0286). The opinions or assertions contained herein are the private views of the authors and should not be construed as official or reflect the views of the US Department of Defence or the Israel Defence Forces. NR 40 TC 10 Z9 10 U1 2 U2 15 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD MAR 13 PY 2012 VL 9 AR 6 DI 10.1186/1550-2783-9-6 PG 7 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 965ED UT WOS:000305748600001 PM 22413851 ER PT J AU Ter-Gabrielyan, N Fromzel, V Ryba-Romanowski, W Lukasiewicz, T Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Ryba-Romanowski, W. Lukasiewicz, T. Dubinskii, M. TI Spectroscopic properties and laser performance of resonantly-pumped cryo-cooled Er3+:GdVO4 SO OPTICS EXPRESS LA English DT Article ID 1.6 MU-M; THERMAL-CONDUCTIVITY; ER3+/YVO4 LASER; ABSORPTION; CRYSTALS; YVO4; NM AB We report a highly efficient cryo-cooled eye-safe laser operation of a resonantly-pumped (in-band) Er3+:GdVO4 single crystal. The maximum continuous wave (CW) power of 10.3 W with 84% slope efficiency was achieved at 1598.7 with pumping at 1538.6 nm by a spectrally-narrowed Er-fiber laser. Under the 1529 nm resonant pumping by a commercially available diode bar stack operating in a quasi-CW (QCW) mode, the laser delivered 37 W of output power with 68% slope efficiency. This is believed to be the first reported cryo-cooled Er3+:GdVO4 laser, resonantly-pumped into the I-4(15/2) -> I-4(13/2) transition. (C) 2012 Optical Society of America C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, Adelphi, MD 20783 USA. [Ryba-Romanowski, W.] Inst Low Temperatures & Struct Res, PL-50422 Wroclaw, Poland. [Lukasiewicz, T.] Inst Elect Mat Technol, PL-01919 Warsaw, Poland. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.tergabrielyan.civ@mail.mil NR 16 TC 8 Z9 8 U1 0 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAR 12 PY 2012 VL 20 IS 6 BP 6080 EP 6084 DI 10.1364/OE.20.006080 PG 5 WC Optics SC Optics GA 913KW UT WOS:000301877700052 PM 22418487 ER PT J AU Johannes, MD Hoang, K Allen, JL Gaskell, K AF Johannes, M. D. Hoang, Khang Allen, J. L. Gaskell, K. TI Hole polaron formation and migration in olivine phosphate materials SO PHYSICAL REVIEW B LA English DT Article ID TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; LITHIUM BATTERIES; ELECTRONIC-STRUCTURE; ION BATTERIES; BASIS-SET; LIFEPO4; LICOPO4; FE; CONDUCTIVITY AB By combining first-principles calculations and experimental x-ray photoemission (XPS) spectroscopy measurements, we investigate the electronic structure of potential Li-ion battery cathode materials LiMPO4 (M = Mn, Fe, Co, Ni) to uncover the underlying mechanisms that determine small hole polaron formation and migration. We show that small hole polaron formation depends on features in the electronic structure near the valence-band maximum and that, calculationally, these features depend on the methodology chosen for dealing with the correlated nature of the transition-metal d-derived states in these systems. Comparison with experiment reveals that a hybrid functional approach is superior to GGA + U in correctly reproducing the XPS spectra. Using this approach, we find that LiNiPO4 cannot support small hole polarons, but that the other three compounds can. The migration barrier is determined mainly by the strong- or weak-bonding nature of the states at the top of the valence band, resulting in a substantially higher barrier for LiMnPO4 than for LiCoPO4 or LiFePO4. C1 [Johannes, M. D.; Hoang, Khang] USN, Ctr Computat Mat Sci, Res Lab, Washington, DC 20375 USA. [Hoang, Khang] George Mason Univ, Computat Mat Sci Ctr, Fairfax, VA 22030 USA. [Allen, J. L.] USA, Res Lab, Adelphi, MD 20783 USA. [Gaskell, K.] Univ Maryland, Surface Anal Ctr, College Pk, MD 20742 USA. RP Johannes, MD (reprint author), USN, Ctr Computat Mat Sci, Res Lab, Washington, DC 20375 USA. RI Hoang, Khang/C-2879-2008; Gaskell, Karen/H-8270-2014 OI Hoang, Khang/0000-0003-1889-0745; FU Army Research Laboratory; Office of Naval Research FX We acknowledge useful technical discussions with J. Wolfenstine, T. R. Jow, and S.-P. Ong. Funding was provided by the Army Research Laboratory and the Office of Naval Research. NR 45 TC 28 Z9 29 U1 10 U2 91 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAR 9 PY 2012 VL 85 IS 11 AR 115106 DI 10.1103/PhysRevB.85.115106 PG 6 WC Physics, Condensed Matter SC Physics GA 906HN UT WOS:000301335700002 ER PT J AU Wagner, GW Peterson, GW Mahle, JJ AF Wagner, George W. Peterson, Gregory W. Mahle, John J. TI Effect of Adsorbed Water and Surface Hydroxyls on the Hydrolysis of VX, GD, and HD on Titania Materials: The Development of Self-Decontaminating Paints SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID CHEMICAL WARFARE AGENTS; C-13 MAS NMR; DELAMINATED ANATASE; NANOSIZE AL2O3; DEGRADATION; NANOTUBES; ADDITIVES; MUSTARD; ALUMINA; TIO2 AB Titania materials such as anatase (TiO2), nanotubular titania (NTT), and nanocrystalline titania (nTiO(2)) exhibit extremely short half-lives for VX, provided adequate surface-adsorbed water is present. The effect of coadsorbed water on the hydrolytic activity of these materials toward VX, GD, and HD was assessed to select the most promising candidate for study in self-decontaminating paints and coatings. The best candidate is nTiO(2), primarily chosen for its extremely short VX half-life at quite high water-content. For the most part, imbedding nTiO(2) into various coatings negatively impacts its reactivity. A notable exception is observed for the case of HD and nTiO(2)/Wax (a paint simulant), where a somewhat shorter half-life is observed compared to the nascent nTiO(2) powder. However, encrusting a painted surface with nTiO(2) powder, leaving it partly exposed rather than wholly imbedded, results in improved reactivity. C1 [Wagner, George W.; Peterson, Gregory W.; Mahle, John J.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Wagner, GW (reprint author), USA, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM george.wagner@us.army.mil FU Cooperative Research and Development Agreement [0714C, W911SR-070C-0062]; Defense Threat Reduction Agency [BA07PRO104] FX Support for this work was provided under Cooperative Research and Development Agreement Project No. 0714C, Contract No. W911SR-070C-0062, and Defense Threat Reduction Agency project BA07PRO104. NR 30 TC 17 Z9 19 U1 7 U2 55 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD MAR 7 PY 2012 VL 51 IS 9 BP 3598 EP 3603 DI 10.1021/ie202063p PG 6 WC Engineering, Chemical SC Engineering GA 903EN UT WOS:000301099000011 ER PT J AU Boudreau, EF Josleyn, M Ullman, D Fisher, D Dalrymple, L Sellers-Myers, K Loudon, P Rusnak, J Rivard, R Schmaljohn, C Hooper, JW AF Boudreau, Ellen F. Josleyn, Matthew Ullman, Diane Fisher, Diana Dalrymple, Lonnie Sellers-Myers, Karen Loudon, Peter Rusnak, Janice Rivard, Robert Schmaljohn, Connie Hooper, Jay W. TI A Phase 1 clinical trial of Hantaan virus and Puumala virus M-segment DNA vaccines for hemorrhagic fever with renal syndrome SO VACCINE LA English DT Article DE Hantavirus; Hemorrhagic fever with renal syndrome; DNA vaccine; Gene gun; Particle-mediated epidermal delivery ID NEUTRALIZING ANTIBODY-RESPONSE; HANTAVIRUS PULMONARY SYNDROME; PROTECTS HAMSTERS; SEOUL-VIRUS; VACCINATION; ELICITS; CHALLENGE AB Candidate DNA vaccines for hemorrhagic fever with renal syndrome expressing the envelope glycoprotein genes of Hantaan (HTNV) or Puumala (PUUV) viruses were evaluated in an open-label, single-center Phase 1 study consisting of three vaccination groups of nine volunteers. The volunteers were vaccinated by particle-mediated epidermal delivery (PMED) three times at four-week intervals with the HTNV DNA vaccine, the PUUV DNA vaccine or both vaccines. At each dosing, the volunteers received 8 mu g DNA/4 mg gold. There were no study-related serious adverse events, and all injection site pain was graded as mild. The most commonly reported systemic adverse events were fatigue, headache, malaise, myalgia, and lymphadenopathy. Blood samples were collected on days 0, 28, 56, 84, 140, and 180, and assayed for the presence of neutralizing antibodies. In the single vaccine groups, neutralizing antibodies to HTNV or PUUV were detected in 30% or 44% of individuals, respectively. In the combined vaccine group, 56% of the volunteers developed neutralizing antibodies to one or both viruses. These results demonstrate that the HTNV and PUUV DNA vaccines are safe and can be immunogenic in humans when delivered by PMED. Published by Elsevier Ltd. C1 [Boudreau, Ellen F.; Josleyn, Matthew; Fisher, Diana; Rusnak, Janice; Rivard, Robert; Schmaljohn, Connie; Hooper, Jay W.] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Loudon, Peter] Pfizer Pharmaceut PGRD, Sandwich Labs, Sandwich CT13 9NJ, Kent, England. [Dalrymple, Lonnie] SAIC, Frederick, MD USA. RP Schmaljohn, C (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD USA. EM connie.schmaljohn@AMEDD.ARMY.MIL OI Hooper, Jay/0000-0002-4475-0415 FU U.S. Army Medical Infectious Diseases Research Program; Medical Research and Materiel Command FX The investigators thank all of the study volunteers for their participation. We are also grateful to the USAMRIID Medical Division staff who assisted in the study. We thank Cindy Rossi and Tamara Clements for ELISA prescreens; Ed Brown, Steve Orr, and Rhonda DaSilva for regulated studies support; Catherine Badger for potency assay oversight; Ryan Adams for regulatory advice; Debbie Coates for quality assurance reviews; Julie Newhart for project management; Denise Bovenzi for her role as a protocol nurse; Melissa Askin for clinical monitoring; Paileen Mongelli for data management; Laurie Smith for document control; and the U.S. Army Medical Infectious Diseases Research Program and the Medical Research and Materiel Command for funding this study. The investigators also thank the PowderMed project team for excellent technical advice and support for this study. NR 27 TC 18 Z9 18 U1 0 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 2 PY 2012 VL 30 IS 11 BP 1951 EP 1958 DI 10.1016/j.vaccine.2012.01.024 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 924AM UT WOS:000302662800006 PM 22248821 ER PT J AU Sakamoto, H Takeo, S Maier, AG Sattabongkot, J Cowman, AF Tsuboi, T AF Sakamoto, Hirokazu Takeo, Satoru Maier, Alexander G. Sattabongkot, Jetsumon Cowman, Alan F. Tsuboi, Takafumi TI Antibodies against a Plasmodium falciparum antigen PfMSPDBL1 inhibit merozoite invasion into human erythrocytes SO VACCINE LA English DT Article DE Blood-stage vaccine; Merozoite; Malaria; PfMSPDBL1; Plasmodium falciparum ID MALARIA PARASITES; WESTERN THAILAND; VACCINE; STAGE; PROTEIN; GROWTH; RECEPTOR; DISCOVERY; IMMUNITY; ELICITS AB One approach to develop a malaria blood-stage vaccine is to target proteins that play critical roles in the erythrocyte invasion of merozoites. The merozoite surface proteins (MSPs) and the erythrocyte-binding antigens (EBAs) are considered promising vaccine candidates, for they are known to play important roles in erythrocyte invasion and are exposed to host immune system. Here we focused on a Plasmodium falciparum antigen, PfMSPDBL1 (encoded by PF10_0348 gene) that is a member of the MSP3 family and has both Duffy binding-like (DBL) domain and secreted polymorphic antigen associated with merozoites (SPAM) domain. Therefore, we aimed to characterize PfMSPDBL1 as a vaccine candidate. Recombinant full-length protein (rFL) of PfMSPDBL1 was synthesized by a wheat germ cell-free system, and rabbit antiserum was raised against rFL. We show that rabbit anti-PfMSPDBL1 antibodies inhibited erythrocyte invasion of wild type parasites in vitro in a dose dependent manner, and the specificity of inhibitory activity was confirmed using PfMSPDBL1 knockout parasites. Pre-incubation of the anti-PfMSPDBL1 antibodies with the recombinant SPAM domain had no effect on the inhibitory activity suggesting that antibodies to this region were not involved. In addition, antibodies to rFL were elicited by P. falciparum infection in malaria endemic area, suggesting the PfMSLDBL1 is immunogenic to humans. Our results suggest that PfMSPDBL1 is a novel blood-stage malaria vaccine candidate. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Sakamoto, Hirokazu; Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. [Maier, Alexander G.; Cowman, Alan F.] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3052, Australia. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Tsuboi, Takafumi] Ehime Univ, Ehime Proteomed Res Ctr, Toon, Ehime 7910295, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. EM tsuboi@ccr.ehime-u.ac.jp RI Cowman, Alan/C-7642-2013; Maier, Alex/A-6499-2009 OI Cowman, Alan/0000-0001-5145-9004; Maier, Alex/0000-0001-7369-1058 FU Bill and Melinda Gates Foundation; Ministry of Education, Culture, Sports, Science and Technology [21249028, 21022034, 23406007, 23117008]; Ministry of Health, Labour, and Welfare, Japan [H21-Chikyukibo-ippan-005] FX This research was supported in part by grants from The Bill and Melinda Gates Foundation, from the Ministry of Education, Culture, Sports, Science and Technology (21249028, 21022034, 23406007, and 23117008), and from the Ministry of Health, Labour, and Welfare, Japan (H21-Chikyukibo-ippan-005). NR 36 TC 18 Z9 18 U1 0 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAR 2 PY 2012 VL 30 IS 11 BP 1972 EP 1980 DI 10.1016/j.vaccine.2012.01.010 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 924AM UT WOS:000302662800009 PM 22248820 ER PT J AU Field, CR Giordano, BC Rogers, DA Lubrano, AL Rose-Pehrsson, SL AF Field, Christopher R. Giordano, Braden C. Rogers, Duane A. Lubrano, Adam L. Rose-Pehrsson, Susan L. TI Characterization of thermal desorption instrumentation with a direct liquid deposition calibration method for trace 2,4,6-trinitrotoluene quantitation SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE Explosives; GC-ECD; Quantitation; 2,4,6-Trinitrotoluene (TNT); Thermal desorption; Cryo-focusing ID ELECTRON-CAPTURE DETECTION; CAPILLARY GAS-CHROMATOGRAPHY; ION MOBILITY SPECTROMETRY; MASS-SPECTROMETRY; EXPLOSIVES; WATER; TNT; NITRAMINE; VAPORS AB The use of thermal desorption systems for the analysis of trace vapors typically requires establishing a calibration curve from vapors generated with a permeation tube. The slow equilibration time of permeation tubes causes such an approach to become laborious when covering a wide dynamic range. Furthermore, many analytes of interest, such as explosives, are not available as permeation tubes. A method for easily and effectively establishing calibration curves for explosive vapor samples via direct deposition of standard solutions on thermal desorption tubes was investigated. The various components of the thermal desorption system were compared to a standard split/splitless inlet. Calibration curves using the direct liquid deposition method with a thermal desorption unit coupled to a cryo-focusing inlet were compared to a standard split/splitless inlet, and a statistical difference was observed but does not eliminate or deter the use of the direct liquid deposition method for obtaining quantitative results for explosive vapors. Published by Elsevier B.V. C1 [Field, Christopher R.; Giordano, Braden C.; Rogers, Duane A.; Rose-Pehrsson, Susan L.] USA, Naval Res Lab, Div Chem, Washington, DC 20375 USA. [Lubrano, Adam L.] Nova Res Inc, Alexandria, VA 22308 USA. RP Field, CR (reprint author), USA, Naval Res Lab, Div Chem, Washington, DC 20375 USA. EM christopher.field@nrl.navy.mil FU Department of Homeland Security Science and Technology Directorate FX The authors would like to acknowledge Mark Hammond for his help in generating figures. Financial support was provided by the Department of Homeland Security Science and Technology Directorate. NR 25 TC 7 Z9 7 U1 1 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD MAR 2 PY 2012 VL 1227 BP 10 EP 18 DI 10.1016/j.chroma.2011.12.087 PG 9 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 909KP UT WOS:000301563700002 PM 22265176 ER PT J AU Carbone, JW McClung, JP Pasiakos, SM AF Carbone, John W. McClung, James P. Pasiakos, Stefan M. TI Skeletal Muscle Responses to Negative Energy Balance: Effects of Dietary Protein SO ADVANCES IN NUTRITION LA English DT Review ID UBIQUITIN-PROTEASOME PATHWAY; AMINO-ACID-METABOLISM; FAT-FREE MASS; WEIGHT-LOSS; MAMMALIAN TARGET; WHOLE-BODY; PROTEOLYTIC PATHWAYS; CALORIC RESTRICTION; NITROGEN-BALANCE; YOUNG MEN AB Sustained periods of negative energy balance decrease body mass due to losses of both fat and skeletal muscle mass. Decreases in skeletal muscle mass are associated with a myriad of negative consequences, including suppressed basal metabolic rate, decreased protein turnover, decreased physical performance, and increased risk of injury. Decreases in skeletal muscle mass in response to negative energy balance are due to imbalanced rates of muscle protein synthesis and degradation. However, the underlying physiological mechanisms contributing to the loss of skeletal muscle during energy deprivation are not well described. Recent studies have demonstrated that consuming dietary protein at levels above the current recommended dietary allowance (0.8 g . kg(-1).d(-1)) may attenuate the loss of skeletal muscle mass by affecting the intracellular regulation of muscle anabolism and proteolysis. However, the specific mechanism by which increased dietary protein spares skeletal muscle through enhanced molecular control of muscle protein metabolism has not been elucidated. This article reviews the available literature related to the effects of negative energy balance on skeletal muscle mass, highlighting investigations that assessed the influence of varying levels of dietary protein on skeletal muscle protein metabolism. Further, the molecular mechanisms that may contribute to the regulation of skeletal muscle mass in response to negative energy balance and alterations in dietary protein level are described. Adv. Nutr. 3: 119-126, 2012. C1 [Carbone, John W.] Eastern Michigan Univ, Sch Hlth Sci, Ypsilanti, MI 48197 USA. [McClung, James P.; Pasiakos, Stefan M.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Pasiakos, SM (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM stefan.pasiakos@us.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014 OI Pasiakos, Stefan/0000-0002-5378-5820 FU United States Army Military Research and Material Command FX Supported by United States Army Military Research and Material Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the United States Army or the Department of Defense. Any citations of commercial organizations and trade names in this report do not constitute an official United States Army endorsement of approval of the products or services of these organizations. NR 73 TC 32 Z9 32 U1 0 U2 18 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 2161-8313 J9 ADV NUTR JI Adv. Nutr. PD MAR PY 2012 VL 3 IS 2 BP 119 EP 126 DI 10.3945/an.111.001792 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 066KO UT WOS:000313219900001 PM 22516719 ER PT J AU Hover, MR AF Hover, Matthew R. TI The occupation of Iraq: a military perspective on lessons learned SO INTERNATIONAL REVIEW OF THE RED CROSS LA English DT Editorial Material DE occupation of Iraq; responsibilities of an occupying power; US military perspective; Coalition Provisional Authority; Operation Iraqi Freedom; military operational planning; training; inter-agency execution C1 [Hover, Matthew R.] USA, Washington, DC USA. [Hover, Matthew R.] USN, Int Law Dept, War Coll, Newport, RI USA. RP Hover, MR (reprint author), US Cent Command, MacDill AFB, FL USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1816-3831 J9 INT REV RED CROSS JI Int. Rev. Red Cross PD MAR PY 2012 VL 94 IS 885 BP 339 EP 346 DI 10.1017/S1816383112000458 PG 8 WC Law SC Government & Law GA 047GA UT WOS:000311825700013 ER PT J AU Hollywood, DM AF Hollywood, Dana M. TI PUTIN, PIPES, AND ALEXSANDR SOLZHENITSYN'S ONE DAY IN THE LIFE OF IVAN DENISOVICH SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Charlottesville, VA USA. RP Hollywood, DM (reprint author), USA, Charlottesville, VA USA. NR 32 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2012 VL 211 BP 316 EP 327 PG 12 WC Law SC Government & Law GA 014JL UT WOS:000309371800008 ER PT J AU Krynicki, DJ AF Krynicki, David J. TI MONSOON: THE INDIAN OCEAN AND THE FUTURE OF AMERICAN POWER SO MILITARY LAW REVIEW LA English DT Book Review C1 USA, Charlottesville, VA USA. RP Krynicki, DJ (reprint author), USA, Charlottesville, VA USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 2012 VL 211 BP 328 EP 336 PG 9 WC Law SC Government & Law GA 014JL UT WOS:000309371800009 ER PT J AU Grau, LW AF Grau, Lester W. TI Afgantsy: The Russians in Afghanistan 1979-1989 SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Grau, Lester W.] USA, Foreign Mil Studies Off, Washington, DC USA. RP Grau, LW (reprint author), USA, Foreign Mil Studies Off, Washington, DC USA. NR 1 TC 0 Z9 0 U1 2 U2 2 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1520-3972 J9 J COLD WAR STUD JI J. Cold War Stud. PD SPR PY 2012 VL 14 IS 2 BP 170 EP 173 PG 4 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA 011ZE UT WOS:000309204100015 ER PT J AU Grau, LW AF Grau, Lester W. TI A Long Goodbye: The Soviet Withdrawal from Afghanistan SO JOURNAL OF COLD WAR STUDIES LA English DT Book Review C1 [Grau, Lester W.] USA, Foreign Mil Studies Off, Washington, DC USA. RP Grau, LW (reprint author), USA, Foreign Mil Studies Off, Washington, DC USA. NR 1 TC 0 Z9 0 U1 2 U2 2 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 1520-3972 J9 J COLD WAR STUD JI J. Cold War Stud. PD SPR PY 2012 VL 14 IS 2 BP 170 EP 173 PG 4 WC History; International Relations; Political Science SC History; International Relations; Government & Law GA 011ZE UT WOS:000309204100016 ER PT J AU Hartsfield, CH AF Hartsfield, Cathy Ho TI DEPORTATION OF VETERANS: THE SILENT BATTLE FOR NATURALIZATION SO RUTGERS LAW REVIEW LA English DT Article ID AFGHANISTAN; IRAQ C1 USA, Judge Advocate Gen Corps, Washington, DC 20310 USA. RP Hartsfield, CH (reprint author), USA, Judge Advocate Gen Corps, Washington, DC 20310 USA. NR 62 TC 0 Z9 0 U1 0 U2 0 PU RUTGERS UNIV PI NEWARK PA SCHOOL LAW 123 WASHINGTON ST, NEWARK, NJ 07102 USA SN 0036-0465 J9 RUTGERS LAW REV JI Rutgers Law Rev. PD SPR PY 2012 VL 64 IS 3 BP 835 EP 862 PG 28 WC Law SC Government & Law GA 009MQ UT WOS:000309030300007 ER PT J AU Choi, KK Jhabvala, MD Forrai, DP Waczynski, A Sun, J Jones, R AF Choi, Kwong-Kit Jhabvala, Murzy D. Forrai, David P. Waczynski, Augustyn Sun, Jason Jones, Robert TI Electromagnetic Modeling of Quantum Well Infrared Photodetectors SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article DE Electromagnetic field modeling; infrared detector; quantum efficiency AB Rigorous electromagnetic field modeling is applied to calculate the quantum efficiency of various quantum well infrared photodetector (QWIP) geometries. We found quantitative agreement between theory and experiment for corrugated-QWIPs, grating-coupled QWIPs, and enhanced-QWIPs, and the model explains adequately the spectral lineshapes of the quantum grid infrared photodetectors. After establishing our theoretical approach, we used the model to optimize the detector structures for 12-micron pixel pitch focal plane arrays. C1 [Choi, Kwong-Kit; Sun, Jason] USA, Res Labs, Adelphi, MD 20833 USA. [Jhabvala, Murzy D.; Waczynski, Augustyn] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Forrai, David P.; Jones, Robert] L 3 Cincinnati Elect, Mason, OH 45040 USA. RP Choi, KK (reprint author), USA, Res Labs, Adelphi, MD 20833 USA. EM kwong.k.choi.civ@mail.mil; murzy.d.jhabvala@nasa.gov; dave.forrai@l-3com.com; augustyn.waczynski-1@nasa.gov; guifu.n.sun.civ@mail.mil; robert.jones@l-3com.com RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 13 Z9 16 U1 0 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD MAR PY 2012 VL 48 IS 3 BP 384 EP 393 DI 10.1109/JQE.2011.2175706 PG 10 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 000SY UT WOS:000308410000005 ER PT J AU Smith, M Farr, JV Sauser, B AF Smith, Meg Farr, John V. Sauser, Brian TI Using Process Simulation to Manage New Product Development Pipeline Throughput SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE Building Engineering Management Actionable Knowledge; Organizational Performance & Assessment; Quality Management ID OPTIMIZATION FRAMEWORK; DEVELOPMENT-PROJECTS; DEVELOPMENT TIME; ACCELERATION AB New product development is complex. Companies often underestimate this complexity and do not invest in efforts to fully understand their new product development system and the ramifications of running that system without control. New product development involves dedicated resources, from multiple disciplines, often for long periods of time. These resources are precious and decisions about how they are utilized should be informed. This work pursues a simulation model of a full new product development pipeline, incorporating the common organizational pathology of taking on too many projects, consistent with the literature and the researchers' experience. This project considers the fact that queues may not occur in all areas of new product development and that resources can be allocated at levels greater than 100%. The phenomenon of decreased efficiencies, when capacity of any discipline is exceeded, has been incorporated to show how the pipeline slows down and unplanned costs increase. C1 [Smith, Meg; Sauser, Brian] Stevens Inst Technol, Hoboken, NJ USA. [Farr, John V.] US Mil Acad, Ctr Nation Reconstruct & Capac Dev, West Point, NY USA. RP Smith, M (reprint author), 325 Corp Dr, Mahwah, NJ 07430 USA. EM msmith7@stevens.edu NR 25 TC 0 Z9 0 U1 2 U2 9 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD MAR PY 2012 VL 24 IS 1 BP 23 EP 34 PG 12 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA 971JJ UT WOS:000306199900004 ER PT J AU Jung, PJ AF Jung, Patrick J. TI Toward the Black Hawk War: The Sauk and Fox Indians and the War of 1812 SO MICHIGAN HISTORICAL REVIEW LA English DT Article C1 [Jung, Patrick J.] Milwaukee Sch Engn, Milwaukee, WI 53202 USA. [Jung, Patrick J.] Legal Aid Soc Milwaukee, Milwaukee, WI USA. [Jung, Patrick J.] Milwaukee Publ Museum, Wisconsin Indian Resources Project, Milwaukee, WI USA. [Jung, Patrick J.] 82nd Airborne Div, Ft Bragg, NC USA. RP Jung, PJ (reprint author), Milwaukee Sch Engn, Milwaukee, WI 53202 USA. NR 145 TC 0 Z9 0 U1 0 U2 1 PU CENTRAL MICHIGAN UNIV CLARKE HISTORICAL LIBRARY PI MT PLEASANT PA MT PLEASANT, MI 48859 USA SN 0360-1846 J9 MICH HIST REV JI Mich. Hist. Rev. PD SPR PY 2012 VL 38 IS 1 BP 27 EP 52 PG 26 WC History SC History GA 956QE UT WOS:000305103400003 ER PT J AU Rauch, SJ AF Rauch, Steven J. TI A Stain Upon the Nation?: A Review of the Detroit Campaign of 1812 in United States Military History SO MICHIGAN HISTORICAL REVIEW LA English DT Article C1 [Rauch, Steven J.] USA, Signal Ctr, Ft Gordon, GA 30905 USA. [Rauch, Steven J.] Univ Michigan, Ann Arbor, MI 48109 USA. [Rauch, Steven J.] USA Command, Washington, DC 20301 USA. [Rauch, Steven J.] Augusta State Univ, Augusta, GA USA. RP Rauch, SJ (reprint author), USA, Signal Ctr, Ft Gordon, GA 30905 USA. NR 63 TC 0 Z9 0 U1 0 U2 0 PU CENTRAL MICHIGAN UNIV CLARKE HISTORICAL LIBRARY PI MT PLEASANT PA MT PLEASANT, MI 48859 USA SN 0360-1846 J9 MICH HIST REV JI Mich. Hist. Rev. PD SPR PY 2012 VL 38 IS 1 BP 129 EP 153 PG 25 WC History SC History GA 956QE UT WOS:000305103400007 ER PT J AU Barbuto, RV AF Barbuto, Richard V. TI The Fall and Recapture of Detroit in the War of 1812: In Defense of William Hull SO MICHIGAN HISTORICAL REVIEW LA English DT Book Review C1 [Barbuto, Richard V.] USA, Command & Gen Staff Coll, Dept Mil Hist, Ft Leavenworth, KS 66027 USA. RP Barbuto, RV (reprint author), USA, Command & Gen Staff Coll, Dept Mil Hist, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CENTRAL MICHIGAN UNIV CLARKE HISTORICAL LIBRARY PI MT PLEASANT PA MT PLEASANT, MI 48859 USA SN 0360-1846 J9 MICH HIST REV JI Mich. Hist. Rev. PD SPR PY 2012 VL 38 IS 1 BP 167 EP 169 PG 3 WC History SC History GA 956QE UT WOS:000305103400015 ER PT J AU Rankin, SJ Levy, SM Warren, JJ Gilmore, JE Broffitt, B AF Rankin, Scott J. Levy, Steven M. Warren, John J. Gilmore, Julie Eichenberger Broffitt, Barbara TI Fluoride content of solid foods impacts daily intake SO JOURNAL OF PUBLIC HEALTH DENTISTRY LA English DT Article DE fluoride content; solid foods; daily intake; fluorides; eating ID UNITED-STATES; CHILDREN; WATER; PATTERNS; DENTIFRICE; BEVERAGES; INGESTION; INFANTS; DRINKS; AREAS AB Objective: To determine the amount of fluoride received from solid foods for a cohort of children. Methods: Parents were asked to complete questionnaires for the preceding week and dietary diaries for 3 days for their children. Data collected at 6, 9, 12, 16, 20, 24, 36, 48, and 60 months were analyzed cross-sectionally. Results: At 6 months of age, children ingested an estimated mean of 8 percent of dietary fluoride from solid foods. At 12 months of age, children ingested an estimated 39 percent of dietary fluoride from solid foods. Although the percentage of fluoride intake from solid foods stabilized from 24 to 60 months (means of 36-39 percent), some children received as much as 85-88 percent of their dietary fluoride from solid foods. Conclusions: Some children receive a substantial portion of dietary fluoride from solid foods. C1 [Rankin, Scott J.] USA, MCDS, Ft Sam Houston, TX 78249 USA. [Levy, Steven M.; Warren, John J.; Broffitt, Barbara] Univ Iowa, Coll Dent, Iowa City, IA 52242 USA. [Gilmore, Julie Eichenberger] Univ Iowa, Inst Clin & Translat Sci, Iowa City, IA USA. RP Rankin, SJ (reprint author), USA, MCDS, 2050 Worth RD, Ft Sam Houston, TX 78249 USA. EM scott.rankin@us.army.mil NR 25 TC 5 Z9 5 U1 0 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-4006 J9 J PUBLIC HEALTH DENT JI J. Public Health Dent. PD SPR PY 2012 VL 72 IS 2 BP 128 EP 134 DI 10.1111/j.1752-7325.2011.00292.x PG 7 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA 952PT UT WOS:000304805300006 PM 22315974 ER PT J AU Neiberg, MS AF Neiberg, Michael S. TI The "Good War" in American Memory SO JOURNAL OF SOCIAL HISTORY LA English DT Book Review C1 [Neiberg, Michael S.] USA, War Coll, Washington, DC 20310 USA. RP Neiberg, MS (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-4529 J9 J SOC HIST JI J. Soc. Hist. PD SPR PY 2012 VL 45 IS 3 BP 870 EP 872 DI 10.1093/jsh/shr113 PG 3 WC History SC History GA 948LQ UT WOS:000304505100031 ER PT J AU Clark, HM Solomon, NP AF Clark, Heather M. Solomon, Nancy Pearl TI Age and Sex Differences in Orofacial Strength SO DYSPHAGIA LA English DT Article DE Orofacial strength; Strength assessment; Age-related changes; Sex differences; Deglutition; Deglutition disorders ID TONGUE STRENGTH; LINGUAL EXERCISE; ORAL PHASE; DYSPHAGIA; ENDURANCE; INDIVIDUALS; PRESSURE AB This study explored age-and sex-related differences in orofacial strength. Healthy adult men (N = 88) and women (N = 83) participated in the study. Strength measures were obtained using the Iowa Oral Performance Instrument (IOPI). Anterior and posterior tongue elevation strength measures were obtained using a standard method. Tongue protrusion and lateralization, cheek compression, and lip compression measures utilized adaptors allowing the participant to exert pressure against the bulb in different orientations. Lip and cheek strength measures were greater for men than women, but tongue strength did not differ between sex groups. Strong correlations between age and strength were not observed. However, group comparisons revealed lower tongue protrusion and lateralization strength in the oldest participants. The oldest participants also exhibited lower anterior and posterior tongue elevation strength relative to the middle-age group. Cheek and lip compression strength demonstrated no age-related differences. The current study supplements and corroborates existing literature that shows that older adults demonstrate lower tongue strength than younger adults. Sex differences were noted such that men demonstrated greater lip and cheek strength but not tongue strength. These data add to the literature on normal orofacial strength, allowing for more informed interpretations of orofacial weakness in persons with dysphagia. C1 [Clark, Heather M.] Appalachian State Univ, Dept Commun Sci & Disorders, Boone, NC 28608 USA. [Solomon, Nancy Pearl] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Clark, HM (reprint author), Appalachian State Univ, Dept Commun Sci & Disorders, Box 32165, Boone, NC 28608 USA. EM clarkhm@appstate.edu FU American Speech-Language-Hearing Foundation; Appalachian State University Research Council FX This project was supported in part by the American Speech-Language-Hearing Foundation and Appalachian State University Research Council. This article expresses the views of the authors, which do not necessarily reflect the official policy of the Department of the Army, Department of Defense, or US Government. NR 22 TC 40 Z9 42 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0179-051X J9 DYSPHAGIA JI Dysphagia PD MAR PY 2012 VL 27 IS 1 BP 2 EP 9 DI 10.1007/s00455-011-9328-2 PG 8 WC Otorhinolaryngology SC Otorhinolaryngology GA 944MO UT WOS:000304207500001 PM 21350818 ER PT J AU Oh, RC Franzos, T Montoya, C AF Oh, Robert C. Franzos, Tracy Montoya, Cathy TI Q/How best to diagnose iron-deficiency anemia in patients with inflammatory disease? SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material C1 [Oh, Robert C.; Franzos, Tracy] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. [Montoya, Cathy] Houston Community Coll, Houston, TX USA. RP Oh, RC (reprint author), Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD MAR PY 2012 VL 61 IS 3 BP 160 EP 161 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 934CZ UT WOS:000303421400010 PM 22393557 ER PT J AU Donoway, T Mandeville, J Gauer, R AF Donoway, Tammy Mandeville, John Gauer, Robert TI When a fetus survives methotrexate exposure SO JOURNAL OF FAMILY PRACTICE LA English DT Article ID LOW-DOSE METHOTREXATE; FAILED METHOTREXATE; ABORTION; TERMINATION; PREGNANCY; ANOMALIES C1 [Donoway, Tammy; Mandeville, John; Gauer, Robert] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. RP Donoway, T (reprint author), Womack Army Med Ctr, Ft Bragg, NC 28307 USA. EM tammy.donoway@us.army.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD MAR PY 2012 VL 61 IS 3 BP E1 EP E4 PG 4 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 934CZ UT WOS:000303421400013 PM 22393560 ER PT J AU Baldassari, CM Kepchar, J Bryant, L Beydoun, H Choi, S AF Baldassari, Cristina M. Kepchar, Jessica Bryant, Lucas Beydoun, Hind Choi, Sukgi TI Changes in Central Apnea Index following Pediatric Adenotonsillectomy SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT AAO-HNSF Annual Meeting and OTO EXPO CY SEP 10-14, 2011 CL San Francisco, CA SP AAO, HNSF DE pediatric sleep-disordered breathing; obstructive sleep-apnea; central sleep apnea; adenotonsillectomy; polysomnogram; pediatrics ID SLEEP-APNEA; CHILDREN; ADOLESCENTS; VALUES AB Objectives. To determine if there are changes in the central apnea index (CAI) when pediatric patients undergo adenotonsillectomy for obstructive sleep apnea (OSA). Study Design. Case series with chart review. Setting. Two tertiary children's hospitals. Subjects and Methods. Children between 1 and 16 years of age who underwent adenotonsillectomy for OSA and had both preoperative and postoperative full-night polysomnography (PSG) with CAI greater than 1 on preoperative PSG were eligible for inclusion. Central apnea was defined as the absence of both inspiratory effort and chest wall movement lasting longer than 20 seconds. Criteria for diagnosis of central sleep apnea (CSA) was CAI greater than 1. Results. A total of 101 children with OSA had preoperative and postoperative PSG. Fifteen of these patients had a preoperative CAI greater than 1. The mean age was 67.7 months (SD, 62.7 months). The CAI ranged from 1.1 to 11.1. The mean preoperative CAI was 3.9 (SD, 2.9), while the mean postoperative CAI was 1.9 (SD, 4.8). There was significant improvement (P = .008) of the CAI following adenotonsillectomy. Ninety percent of subjects with mild CSA (CAI between 1 and 5) had postoperative resolution of their disease. There was also significant improvement (P = .004) in the obstructive apnea hypopnea index (AHI), with the mean preoperative AHI of 22.8 (SD, 19.8) decreasing to an AHI of 5.5 (SD, 6.5) postoperatively. Conclusions. Children with OSA and mild CSA on preoperative PSG showed significant improvement in CAI following adenotonsillectomy. Future studies are needed to determine the clinical significance of CSA in children with OSA and to identify treatment strategies. C1 [Baldassari, Cristina M.; Bryant, Lucas] Childrens Hosp Kings Daughters, Dept Otolaryngol Head & Neck Surg, Eastern Virginia Med Sch, Norfolk, VA 23507 USA. [Kepchar, Jessica] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. [Beydoun, Hind] Eastern Virginia Med Sch, Dept Biostat, Norfolk, VA 23501 USA. [Choi, Sukgi] Childrens Natl Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20010 USA. RP Baldassari, CM (reprint author), Childrens Hosp Kings Daughters, Dept Otolaryngol Head & Neck Surg, Eastern Virginia Med Sch, 601 Childrens Lane,2nd Floor, Norfolk, VA 23507 USA. EM cristina.baldassari@chkd.org NR 9 TC 9 Z9 10 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD MAR PY 2012 VL 146 IS 3 BP 487 EP 490 DI 10.1177/0194599811428118 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 935TX UT WOS:000303545100026 PM 22075072 ER PT J AU Harnish, RA Johnson, GE McMichael, GA Hughes, MS Ebberts, BD AF Harnish, Ryan A. Johnson, Gary E. McMichael, Geoffrey A. Hughes, Michael S. Ebberts, Blaine D. TI Effect of Migration Pathway on Travel Time and Survival of Acoustic-Tagged Juvenile Salmonids in the Columbia River Estuary SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID PASSIVE INTEGRATED TRANSPONDERS; CHINOOK SALMON; ONCORHYNCHUS-TSHAWYTSCHA; CASPIAN TERNS; DELAYED MORTALITY; AVIAN PREDATION; PACIFIC SALMON; COHO SALMON; OREGON; MODEL AB We applied acoustic telemetry methods to characterize migration pathways and estimate associated travel times and survival probabilities for juvenile Chinook salmon Oncorhynchus tshawytscha and steelhead O. mykiss migrating downstream through the Columbia River estuary (from river kilometer [rkm] 86 to rkm 8). Acoustic-tagged fish were detected as migrating in the navigation channel and in off-channel areas at each of the estuarine reaches we examined during May-August 2010. However, the majority of fish traveled in the main navigation channel from rkm 86 to rkm 37, at which point most fish left the river-influenced navigation channel; crossed a broad, shallow tidal flat; and migrated the final 37 km in a secondary channel, which was characterized as having greater tidal transport than the navigation channel. The pathway used by acoustic-tagged smolts to migrate through the estuary affected their rate of travel. In most reaches, navigation channel migrants traveled significantly faster than fish that migrated through off-channel areas. Contrary to observations from previous studies, smolts that migrated through off-channel areas at a slower rate did not experience lower survival than their cohorts that used the navigation channel. Although no significant differences in survival probability were observed between navigation channel migrants and off-channel migrants, areas of high mortality were identified between rkm 37 and rkm 8. Dispersion of juvenile salmonids into multiple pathways during downstream migration can be beneficial in terms of increased expression of life history diversity and resiliency to environmental perturbations. Our results, which document juvenile salmon migration pathways and associated travel time and survival through a large estuary, can be used to focus future research and management activities in areas identified as having high mortality and therefore can be used to aid in the recovery of Endangered Species Act-listed salmon populations. C1 [Harnish, Ryan A.; McMichael, Geoffrey A.; Hughes, Michael S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA. [Johnson, Gary E.] Pacific NW Natl Lab, Coastal Ecosyst Res Grp, Portland, OR 97204 USA. [Ebberts, Blaine D.] USA, Corps Engineers, Portland, OR 97204 USA. RP Harnish, RA (reprint author), Pacific NW Natl Lab, Ecol Grp, POB 999, Richland, WA 99352 USA. EM ryan.harnish@pnl.gov FU U.S. Army Corps of Engineers (USACE) Portland District FX We thank the U.S. Army Corps of Engineers (USACE) Portland District for funding this research. Brad Eppard (USACE Portland District) provided excellent oversight in the use of the JSATS as it relates to survival and dam passage and was instrumental in standardizing telemetry equipment and protocols for USACE-funded research in the Columbia River basin. Cindy Studebaker (USACEPortland District) was the technical lead for USACE during most of this work; Liz Smock (USACE Portland District) was very helpful in coordinating receiver deployment and channel maintenance activities. Dave Nichols (Ilwaco Fuel Dock) was a great host and provided support for our shore-based operations in Ilwaco. We thank the Pacific Northwest National Laboratory (PNNL) North Bonneville crew that collected and tagged fish at John Day Dam and provided tagging data; we sincerely appreciate the hard work and help provided by PNNL North Bonneville staff, including Mark Weiland, Gene Ploskey, James Hughes, Shon Zimmerman, and Eric Fischer. We are grateful to the following PNNL staff for their assistance: Rich Brown and Kate Deters for surgery training; Eric Choi, Brian LaMarche, Daniel Deng, Thomas Seim, and Thomas Carlson for JSATS development; Brian Bellgraph, Lori Ortega, KateDeters, Jayson Martinez, Tao Fu, and Noel Tavan for receiver testing; Kate Hall and Scott Titzler for receiver deployment; Kenneth Ham, Jina Kim, and Donna Trott for data processing; SaraKallio for map production; and Andrea Currie for manuscript editing. NR 68 TC 18 Z9 18 U1 2 U2 25 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD MAR PY 2012 VL 141 IS 2 BP 507 EP 519 DI 10.1080/00028487.2012.670576 PG 13 WC Fisheries SC Fisheries GA 936MB UT WOS:000303593400023 ER PT J AU Field, LA Love, B Deyarmin, B Hooke, JA Shriver, CD Ellsworth, RE AF Field, Lori A. Love, Brad Deyarmin, Brenda Hooke, Jeffrey A. Shriver, Craig D. Ellsworth, Rachel E. TI Identification of differentially expressed genes in breast tumors from African American compared with Caucasian women SO CANCER LA English DT Article DE breast cancer; African American; disparities; gene expression; microarray ID PROSTATE-CANCER; UNITED-STATES; BLACK-WOMEN; LACTOFERRIN; CARCINOMA; PROGNOSIS; SUBTYPES; SURVIVAL; MICROENVIRONMENT; PREVALENCE AB BACKGROUND: Breast tumors from African American women have less favorable pathological characteristics and higher mortality rates than those of Caucasian women. Although socioeconomic status may influence prognosis, biological factors are also likely to contribute to tumor behavior. METHODS: Patients with invasive breast cancer were matched by age, grade, and estrogen receptor status; patients with benign disease were matched by age and diagnosis type. RNA from laser microdissected tumors and whole-sectioned nonmalignant breast tissues was hybridized to HG U133A 2.0 microarrays. Data were analyzed using Partek Genomics Suite using a cutoff of P <.001, > 1.5-fold change, and results were validated by quantitative real-time polymerase chain reaction. RESULTS: Clinicopathological factors did not differ significantly between groups for age at diagnosis, tumor size or stage, lymph node or human epidermal growth receptor 2 status, intrinsic subtype, or mortality. Two-way analysis of the tumor specimens revealed 25 probes representing 23 genes differentially expressed between populations; hierarchical clustering classified 24 of 26 African American women and 25 of 26 Caucasian women correctly. In the nonmalignant specimens, 15 probes representing 13 genes were differentially expressed, including 5 genes that also differed in the tumor specimens; these genes were able to correctly classify nonmalignant breast specimens from 20 of 22 of African American women and all of the Caucasian women. CONCLUSIONS: Despite matching of tumors by pathological characteristics, molecular profiles differed between African American women and Caucasian women in both invasive tumors and benign breast tissues. These differentially expressed genes, including CRYBB2, PSPHL, and SOS1, are involved in cellular growth and differentiation, invasion, metastasis, and immune response and thus may contribute to the poor outcome in African American women. Cancer 2012; 118: 1334-44. (C) 2011 American Cancer Society. C1 [Field, Lori A.; Deyarmin, Brenda] Windber Res Inst, Windber, PA USA. [Love, Brad] BioReka LLC, Lutherville Timonium, MD USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Windber, PA USA. RP Ellsworth, RE (reprint author), 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org FU United States Department of Defense (Military Molecular Medicine Initiative) [MDA W81XWH-05-2-0075] FX This research was supported by a grant from the United States Department of Defense (Military Molecular Medicine Initiative MDA W81XWH-05-2-0075, protocol 01-20006). NR 42 TC 23 Z9 23 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD MAR 1 PY 2012 VL 118 IS 5 BP 1334 EP 1344 DI 10.1002/cncr.26405 PG 11 WC Oncology SC Oncology GA 897QD UT WOS:000300667800021 PM 21800289 ER PT J AU Enewold, L Zhou, J McGlynn, KA Devesa, SS Shriver, CD Potter, JF Zahm, SH Zhu, KM AF Enewold, Lindsey Zhou, Jing McGlynn, Katherine A. Devesa, Susan S. Shriver, Craig D. Potter, John F. Zahm, Shelia H. Zhu, Kangmin TI Racial Variation in Tumor Stage at Diagnosis Among Department of Defense Beneficiaries SO CANCER LA English DT Article DE Department of Defense health system; military; racial disparity; tumor state; equal health care access ID BREAST-CANCER MORTALITY; HEALTH-CARE-SYSTEM; AFRICAN-AMERICAN; UNITED-STATES; DISPARITIES; SURVIVAL; OUTCOMES; WHITE; RACE AB BACKGROUND: Tumor stage at diagnosis often varies by racial/ethnic group, possibly because of inequitable health care access. Within the Department of Defense (DoD) Military Health System, beneficiaries have equal health care access. The objective of this study was to determine whether tumor stage differed between whites and blacks with breast, cervical, colorectal, and prostate cancers, which have effective screening regimens, based on data from the DoD Automated Cancer Tumor Registry from 1990 to 2003. METHODS: Distributions of tumor stage (localized vs nonlocalized) between whites and blacks in the military were compared stratified by sex, active duty status, and age at diagnosis. Logistic regression was used to further adjust for age, marital status, year of diagnosis, geographic region, military service branch, and tumor grade. Distributions of tumor stage were then compared between the military and general populations. RESULTS: Racial differences in the distribution of stage were significant only among nonactive duty beneficiaries. After adjusting for covariates, earlier stages of breast cancer after age 49 years and prostate cancer after age 64 years were significantly more common among white than black nonactive duty beneficiaries (P < .05), although the absolute difference was minimal for prostate cancer. Racial differences in stage for cervical and colorectal cancers were not significant after adjustment. Compared with the general population, racial differences in the military were similar or were slightly attenuated. CONCLUSIONS: Racial disparities in stage at diagnosis were apparent in the DoD equal-access health care system among older nonactive duty beneficiaries. Socioeconomic status, supplemental insurance, cultural beliefs, and biologic factors may be related to these results. Cancer 2012;118:1397-403. (C) 2011 American Cancer Society. C1 [Enewold, Lindsey] Armed Forces Inst Pathol, US Mil Canc Inst, Walter Reed Army Med Ctr, Washington, DC 20306 USA. [McGlynn, Katherine A.; Devesa, Susan S.; Zahm, Shelia H.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Potter, John F.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biometr, Bethesda, MD USA. RP Enewold, L (reprint author), Armed Forces Inst Pathol, US Mil Canc Inst, Walter Reed Army Med Ctr, Bldg 54,Room N1512,6825 16th St NW, Washington, DC 20306 USA. EM lindsey.enewold@us.army.mil RI Zahm, Shelia/B-5025-2015 FU United States Military Cancer Institute; United States Military Cancer Institute through the Uniformed Services University of the Health Sciences; Henry M. Jackson Foundation for the Advancement of Military Medicine; Division of Cancer Epidemiology and Genetics, National Cancer Institute FX The authors thank the Armed Forces Institute of Pathology for providing the Automated Cancer Tumor Registry data, especially Ms. Annette Anderson for coordinating the process; Dr. Hongyu Wu of the US Marine Corp Institute for her help in computer programming; Dr. Larry Maxwell, Mr. William Mahr, and Ms. Anne Dimke of the United States Military Cancer Institute for their support and help; and Dr. Sally Bushhouse of the Minnesota Cancer Surveillance System for providing the useful Minnesota Patient and Tumor Resolution Algorithms document.; This research was supported by the United States Military Cancer Institute through the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine and by the Division of Cancer Epidemiology and Genetics, National Cancer Institute. NR 30 TC 5 Z9 6 U1 1 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD MAR 1 PY 2012 VL 118 IS 5 BP 1397 EP 1403 DI 10.1002/cncr.26208 PG 7 WC Oncology SC Oncology GA 897QD UT WOS:000300667800027 PM 21837685 ER PT J AU Alvarez-Secord, A Barnett, J Ledermann, J Peterson, B Myers, E Havrilesky, L AF Alvarez-Secord, A. Barnett, J. Ledermann, J. Peterson, B. Myers, E. Havrilesky, L. TI Cost-effectiveness of homologous recombination defect testing to target PARP inhibitor use in platinum-sensitive recurrent ovarian cancer SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Alvarez-Secord, A.; Peterson, B.; Myers, E.; Havrilesky, L.] Duke Univ, Med Ctr, Durham, NC USA. [Barnett, J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Ledermann, J.] UCL Canc Inst, London, England. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 222 BP S92 EP S93 DI 10.1016/j.ygyno.2011.12.223 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600222 ER PT J AU Barnett, I Alvarez-Secord, A Cohn, D Leath, C Peterson, B Myers, E Havrilesky, L AF Barnett, I. Alvarez-Secord, A. Cohn, D. Leath, C. Peterson, B. Myers, E. Havrilesky, L. TI Cost-effectiveness of a predictive biomarker for bevacizumab responsiveness in the primary treatment of ovarian cancer SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Barnett, I.; Leath, C.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Alvarez-Secord, A.; Peterson, B.; Myers, E.; Havrilesky, L.] Duke Univ, Med Ctr, Durham, NC USA. [Cohn, D.] Ohio State Univ, Columbus, OH 43210 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 156 BP S66 EP S66 DI 10.1016/j.ygyno.2011.12.157 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600156 ER PT J AU Brooks, R Darcy, K Tritchler, D Gold, D Birrer, M Rader, J Kizer, N Thaker, P Mutch, D Goodfellow, P AF Brooks, R. Darcy, K. Tritchler, D. Gold, D. Birrer, M. Rader, J. Kizer, N. Thaker, P. Mutch, D. Goodfellow, P. TI Single nucleotide polymorphisms in IL8RB, EGFR, ABL1, and SPAG9 Are associated with lymph node metastasis in endometrial cancer: A Gynecologic Oncology Group and Washington University School of Medicine study SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Brooks, R.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Darcy, K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Tritchler, D.] Univ Toronto, Toronto, ON, Canada. [Gold, D.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Birrer, M.] Harvard Univ, Massachusetts Gen Hosp, Boston, MA 02115 USA. [Rader, J.] Med Coll Wisconsin, Milwaukee, WI 53226 USA. [Kizer, N.; Thaker, P.; Mutch, D.; Goodfellow, P.] Washington Univ, Sch Med, St Louis, MO USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 39 BP S17 EP S17 DI 10.1016/j.ygyno.2011.12.040 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600041 ER PT J AU Havrilesky, L Sfakianos, G Barnett, J Myers, E AF Havrilesky, L. Sfakianos, G. Barnett, J. Myers, E. TI Comparative effectiveness of three triage strategies for women presenting to a gynecologist with a pelvic mass SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Havrilesky, L.; Sfakianos, G.; Myers, E.] Duke Univ, Med Ctr, Durham, NC USA. [Barnett, J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 178 BP S75 EP S75 DI 10.1016/j.ygyno.2011.12.179 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600178 ER PT J AU Phippen, N Leath, C Chino, J Jewell, E Havrilesky, L Barnett, J AF Phippen, N. Leath, C. Chino, J. Jewell, E. Havrilesky, L. Barnett, J. TI Cost effectiveness of concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin compared with standard concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Phippen, N.; Leath, C.; Barnett, J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Chino, J.; Havrilesky, L.] Duke Univ, Med Ctr, Durham, NC USA. [Jewell, E.] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 112 BP S48 EP S48 DI 10.1016/j.ygyno.2011.12.113 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600114 ER PT J AU Rodriguez, N Miller, A Richard, S Rungruang, B Hamilton, C Bookman, M Maxwell, G Horowitz, N Krivak, T AF Rodriguez, N. Miller, A. Richard, S. Rungruang, B. Hamilton, C. Bookman, M. Maxwell, G. Horowitz, N. Krivak, T. TI Upper abdominal procedures in advanced stage ovarian or primary peritoneal carcinoma patients with minimal or no gross residual disease: An analysis of GOG 182 SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Rodriguez, N.] Loma Linda Univ, Med Ctr, Loma Linda, CA USA. [Miller, A.] Roswell Pk Canc Inst, Buffalo, NY 14263 USA. [Richard, S.; Rungruang, B.; Krivak, T.] UPMC, Magee Womens Hosp, Pittsburgh, PA USA. [Hamilton, C.; Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Bookman, M.] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA. [Horowitz, N.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 54 BP S23 EP S24 DI 10.1016/j.ygyno.2011.12.055 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600055 ER PT J AU Rungruang, B Miller, A Richard, S Rodriguez, N Bookman, M Hamilton, C Maxwell, G Horowitz, N Krivak, T AF Rungruang, B. Miller, A. Richard, S. Rodriguez, N. Bookman, M. Hamilton, C. Maxwell, G. Horowitz, N. Krivak, T. TI Advanced stage ovarian cancer - Does complex surgery improve survival? An analysis of GOG 182 SO GYNECOLOGIC ONCOLOGY LA English DT Meeting Abstract C1 [Rungruang, B.; Richard, S.; Krivak, T.] UPMC, Magee Womens Hosp, Pittsburgh, PA USA. [Miller, A.] Roswell Pk Canc Inst, Stat & Data Ctr, Gynecol Oncol Grp, Buffalo, NY 14263 USA. [Rodriguez, N.] Loma Linda Univ, Med Ctr, Loma Linda, CA USA. [Bookman, M.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. [Hamilton, C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Maxwell, G.] Womens Hlth Integrated Res Ctr, Annandale, VA USA. [Horowitz, N.] Brigham & Womens Hosp, Boston, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAR PY 2012 VL 125 SU 1 MA 53 BP S23 EP S23 DI 10.1016/j.ygyno.2011.12.054 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 931NW UT WOS:000303227600054 ER PT J AU Frolov, T Darling, KA Kecskes, LJ Mishin, Y AF Frolov, T. Darling, K. A. Kecskes, L. J. Mishin, Y. TI Stabilization and strengthening of nanocrystalline copper by alloying with tantalum SO ACTA MATERIALIA LA English DT Article DE Nanocrystalline materials; Molecular dynamics; Segregation; Grain growth ID GRAIN-BOUNDARY MIGRATION; MOLECULAR-DYNAMICS; DIFFUSION BARRIER; MICROSTRUCTURAL EVOLUTION; THERMAL-STABILITY; FAILURE-MECHANISM; CU; TEMPERATURE; SYSTEM; FILMS AB Nanocrystalline Cu-Ta alloys belong to an emerging class of immiscible high-strength materials with a significant potential for high-temperature applications. Using molecular dynamics simulations with an angular-dependent interatomic potential, we study the effect of Ta on the resistance to grain growth and mechanical strength of nanocrystalline Cu-6.5 at.% Ta alloys. Ta segregation at grain boundaries greatly increases structural stability and strength in comparison with pure copper and alloys with a uniform distribution of the same amount of Ta. At high temperatures, the segregated Ta atoms agglomerate and form a set of nanoclusters located at grain boundaries. These nanoclusters are capable of pinning grain boundaries and effectively preventing grain growth. It is suggested that the nanoclusters are precursors to the formation of larger Ta particles found in Cu-Ta alloys experimentally. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Frolov, T.; Mishin, Y.] George Mason Univ, Dept Phys & Astron, Fairfax, VA 22030 USA. [Darling, K. A.; Kecskes, L. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mishin, Y (reprint author), George Mason Univ, Dept Phys & Astron, MSN 3F3, Fairfax, VA 22030 USA. EM ymishin@gmu.edu RI Kecskes, Laszlo/F-6880-2014; Mishin, Yuri/P-2020-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; FU US Army Research Laboratory [W911QX-11-P-0187] FX This work was supported in part by the US Army Research Laboratory under Contract W911QX-11-P-0187. Additionally, the authors would like to recognize Mr. Brady G. Butler for performing the TEM examination of the ball-milled Cu-10 at.% Ta sample. NR 55 TC 43 Z9 43 U1 2 U2 76 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD MAR PY 2012 VL 60 IS 5 BP 2158 EP 2168 DI 10.1016/j.actamat.2012.01.011 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 926MN UT WOS:000302835300026 ER PT J AU Pan, Z Xu, F Mathaudhu, SN Kecskes, LJ Yin, WH Zhang, XY Hartwig, KT Wei, Q AF Pan, Z. Xu, F. Mathaudhu, S. N. Kecskes, L. J. Yin, W. H. Zhang, X. Y. Hartwig, K. T. Wei, Q. TI Microstructural evolution and mechanical properties of niobium processed by equal channel angular extrusion up to 24 passes SO ACTA MATERIALIA LA English DT Article DE Niobium; Severe plastic deformation; Microstructure; Mechanical properties; Grain boundaries ID SEVERE PLASTIC-DEFORMATION; STRAIN-RATE SENSITIVITY; CENTERED-CUBIC METALS; ULTRAFINE GRAIN SIZES; HIGH-PRESSURE TORSION; NANOSTRUCTURED METALS; CONSTITUTIVE RELATIONS; TENSILE DUCTILITY; SINGLE-CRYSTALS; SHEAR BANDS AB We have systematically investigated the microstructural evolution of niobium (Nb) subjected to severe plastic deformation via equal channel angular extrusion (ECAE) up to 24 passes. The starting Nb billet material consists of a centimeter-scale grain size with a columnar structure. We have found that the grain size reduction of the Nb is almost saturated at similar to 300 nm after eight passes of ECAE. However, the population of high-angle grain boundaries continues to increase with further ECAE, and no saturation appears to have been reached at 24 passes. We have evaluated the mechanical properties of the samples with different number of ECAE passes over a wide range of strain rates, from quasi-static to high strain rates. We have used strain-rate jump tests to examine the strain-rate sensitivity (SRS) of the processed samples and found that the SRS of the ECAE-processed Nb is similar to 0.012, which is a factor of three smaller than that of the coarse-grained counterpart. The activation volume derived for plastic deformation indicates that the double-kink formation of screw dislocations is still the predominant deformation mechanism in the ECAE-processed Nb. Quasi-static true stress strain curves exhibit elastic-nearly perfectly plastic behavior. The quasi-static yield strength is also nearly saturated after eight passes of ECAE. High-strain-rate compressive true stress-strain curves show uniform flow softening. However, the dynamic peak stress keeps rising with an increased number of ECAE passes, suggesting a strong grain boundary contribution to dynamic strengthening. Scanning electron microscopy of post-loaded surfaces displays a morphology of diffuse shear bands accompanying highly compressed grains. In our report, we demonstrate that grain boundaries of severely deformed metals play different roles at low, quasi-static vs. high-strain rates of mechanical loading. The difference is primarily determined by the strength of grain boundaries acting as dislocation barriers at different loading rates. This discovery is significant for the understanding of the effect of the microstructure as a function of the applied loading rate. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Pan, Z.; Yin, W. H.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Xu, F.; Zhang, X. Y.] Chongqing Univ, Sch Mat Sci & Engn, Chongqing 400030, Peoples R China. [Mathaudhu, S. N.] USA, Res Off, Res Lab, Res Triangle Pk, NC 27709 USA. [Kecskes, L. J.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Hartwig, K. T.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Mathaudhu, Suveen/B-4192-2009; Kecskes, Laszlo/F-6880-2014; Pan, Zhiliang/A-8061-2009 OI Kecskes, Laszlo/0000-0002-1342-3729; Pan, Zhiliang/0000-0003-3899-8761 FU US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073]; National Natural Science Foundation of China [51071183, 50890170]; Fundamental Research Funds for the Central Universities [CDJXS11132225]; Major State Basic Research Development Program of China (973 Program) [2010CB631004] FX Q. Wei would like to acknowledge the support from US Army Research Laboratory under Contract Nos. W911QX-06-C-0124 and W911QX-08-C-0073. X.Y. Zhang thanks the National Natural Science Foundation of China (Contract Nos. 51071183, 50890170), Fundamental Research Funds for the Central Universities (Contract No. CDJXS11132225) and Major State Basic Research Development Program of China (973 Program) (Contract No. 2010CB631004). NR 83 TC 10 Z9 10 U1 1 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 EI 1873-2453 J9 ACTA MATER JI Acta Mater. PD MAR PY 2012 VL 60 IS 5 BP 2310 EP 2323 DI 10.1016/j.actamat.2011.12.019 PG 14 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 926MN UT WOS:000302835300041 ER PT J AU Nielsen, SC AF Nielsen, Suzanne C. TI The soldier and the state: the theory and politics of civil-military relations SO INTERNATIONAL AFFAIRS LA English DT Book Review C1 [Nielsen, Suzanne C.] US Mil Acad, Dept Social Sci, West Point, PA USA. NR 25 TC 1 Z9 1 U1 1 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0020-5850 J9 INT AFF JI Int. Aff. PD MAR PY 2012 VL 88 IS 2 BP 369 EP 376 DI 10.1111/j.1468-2346.2012.01076.x PG 8 WC International Relations SC International Relations GA 911GH UT WOS:000301704800010 ER PT J AU Price, BC AF Price, Bryan C. TI Targeting Top Terrorists How Leadership Decapitation Contributes to Counterterrorism SO INTERNATIONAL SECURITY LA English DT Article ID ORGANIZATIONS; SUCCESSION; ASSASSINATIONS; NETWORKS; WAR AB Several states, including Israel and the United States, have put decapitation tactics, which seek to kill or capture leaders of terrorist organizations, at the forefront of their counterterrorism efforts. The vast majority of scholarly work on decapitation suggests, however, that leadership decapitation is ineffective at best and counterproductive at worst. Contrary to this conventional wisdom, leadership decapitation significantly increases the mortality rate of terrorist groups, although the results indicate that the effect of decapitation decreases with the age of the group, even to a point where it may have no effect at all. This finding helps to explain the previously perplexing mixed record of decapitation effectiveness. Terrorist groups are especially susceptible to leadership decapitation because their organizational characteristics (they are violent, clandestine, and values based) amplify the difficulties of leadership succession. Additionally, in contrast to the conventional wisdom regarding the durability of terrorist groups, politically relevant terrorist groups (defined as those with at least four attacks including one attack resulting in a fatality) endure significantly longer than previously believed. C1 [Price, Bryan C.] USA, Washington, DC 20310 USA. [Price, Bryan C.] US Mil Acad, West Point, NY USA. RP Price, BC (reprint author), USA, Washington, DC 20310 USA. NR 96 TC 40 Z9 40 U1 1 U2 17 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 0162-2889 J9 INT SECURITY JI Int. Secur. PD SPR PY 2012 VL 36 IS 4 BP 9 EP + PG 39 WC International Relations SC International Relations GA 925SG UT WOS:000302780900001 ER PT J AU Foster, GA Alviar, A Neumeier, R Wootten, A AF Foster, Gwendolyn A. Alviar, Aimee Neumeier, Robin Wootten, Amy TI A Tri-Service Perspective on the Implementation of a Centering Pregnancy Model in the Military SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Article DE centering pregnancy; military; group prenatal care; obstetrics; women's health care ID GROUP PRENATAL-CARE AB With the rising cost of health care, group prenatal care has come into the forefront as a viable, evidence-based option for care delivery. In this article, the authors from three different branches of service (Army, Navy, Air Force) review the strategies and challenges of implementing a centering pregnancy model at military treatment facilities. JOGNN, 41, 315-321; 2012. DOI: 10.1111/j.1552-6909.2012.01345.x C1 [Foster, Gwendolyn A.] OB GYN Outpatient Serv, Travis AFB, CA USA. [Alviar, Aimee] Family Hlth Clin, Whiteman AFB, MO USA. [Neumeier, Robin] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Wootten, Amy] Camp Pendleton, Oceanside, CA USA. RP Foster, GA (reprint author), David Grant Med Ctr, 60 MSGS SGCG 101 Bodin Circle, Travis AFB, CA 94535 USA. EM gwendolyn.foster@us.af.mil NR 17 TC 1 Z9 1 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0884-2175 J9 JOGNN-J OBST GYN NEO JI JOGNN PD MAR-APR PY 2012 VL 41 IS 2 BP 315 EP 321 DI 10.1111/j.1552-6909.2012.01345.x PG 7 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA 927ZC UT WOS:000302948200020 PM 22834853 ER PT J AU Wetzel, ED Wagner, NJ AF Wetzel, Eric D. Wagner, Norman J. TI Comment on "Evaluation of Shear-Thickening-Fluid Kevlar for Large-Fragment-Containment Applications" SO JOURNAL OF AIRCRAFT LA English DT Editorial Material ID ARMOR BLUNT TRAUMA; BALLISTIC IMPACT; FAN CONTAINMENT; FABRICS; ENGINE; PROTECTION; RESISTANCE; SILICA; BLADE C1 [Wetzel, Eric D.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Wagner, Norman J.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. RP Wetzel, ED (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM eric.wetzel@us.army.mil RI Wagner, Norman/B-6558-2012 OI Wagner, Norman/0000-0001-9565-619X NR 38 TC 3 Z9 3 U1 0 U2 25 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAR-APR PY 2012 VL 49 IS 2 BP 671 EP 673 DI 10.2514/1.C031497 PG 3 WC Engineering, Aerospace SC Engineering GA 925JV UT WOS:000302758400035 ER PT J AU Bhattacharjee, AK Kuca, K Musilek, K Gordon, RK AF Bhattacharjee, Apurba K. Kuca, Kamil Musilek, Kamil Gordon, Richard K. TI An In Silico Stereo-electronic Comparison of Conventional Pyridinium Oximes and K-oximes for Organophosphate (OP) Poisoning SO MEDICINAL CHEMISTRY LA English DT Article DE Stereoelectronic features; oximes; nerve agents; OP-inhibited AChE; modeling ID ACETYLCHOLINESTERASE REACTIVATORS; INHIBITED ACETYLCHOLINESTERASE; STEREOELECTRONIC PROPERTIES; CRYSTAL-STRUCTURES; NERVE AGENTS; TABUN; OBIDOXIME; DESIGN; MODEL; HI-6 AB A comparative analysis of stereo-electronic properties of five cholinesterase reactivators (pralidoxime (2-PAM), trimedoxime, obidoxime, HI-6, and HLo-7) and six "K-oximes" was performed to assess their roles in reactivating OP-inhibited phosphorylated serine residue of mouse AChE. Quantum mechanical (QM) calculations starting from semi-empirical to ab initio levels were sequentially performed with hierarchical basis sets to obtain the individual optimized geometry and stereo-electronic properties of the eleven oximes. Next, solvation effects were computed on the optimized structures using two different (PCM and COSMO) QM models. Results indicate that properties, such as the distance between the bisquarternary nitrogen atoms, surface area, molecular volume, and hydrophilicity have important roles in the reactivation of OP-inhibited AChE. Electronic attributes, such as the molecular electrostatic potentials and orbital energies were also found to be important parameters for reactivation. Nucleophilicity of the oxygen atoms at the terminal regions, electrophilicity in the central regions of the oximes, and location of the molecular orbitals on aromatic rings have significant roles for the experimentally observed reactivations in several OP agents inhibited mouse AChE. Analysis of solvation free energy indicates high solute polarization and dispersion energies of the oximes to be particularly critical for the tabun-inhibited mouse AChE, whereas lower values of these properties favor reactivation against other OP agents, such as soman, sarin and cyclosarin. Feature mappings of our recently reported pharmacophore model were also observed to be consistent with the above observed electronic properties. In silico toxicity evaluation on these oximes predicts the K-oximes to have somewhat higher oral toxicity compared to the other bispyridinium oximes. C1 [Bhattacharjee, Apurba K.; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, Silver Spring, MD 20910 USA. [Kuca, Kamil; Musilek, Kamil] Fac Mil Hlth Sci, Ctr Adv Studies, Hradec Kralove, Czech Republic. [Kuca, Kamil] Fac Mil Hlth Sci, Dept Toxicol, Hradec Kralove, Czech Republic. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Apurba.Bhattacharjee@amedd.army.mil FU DTRA [1E0057_08_WR_C] FX Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting true views of the Department of the Army or the Department of Defense. Funding from DTRA (#1E0057_08_WR_C) is gratefully acknowledged. NR 41 TC 1 Z9 1 U1 2 U2 10 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1573-4064 J9 MED CHEM JI Med. Chem. PD MAR PY 2012 VL 8 IS 2 BP 230 EP 245 PG 16 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 928OU UT WOS:000302993200012 PM 22385173 ER PT J AU Vecherin, SN Wilson, DK Ostashev, VE AF Vecherin, Sergey N. Wilson, D. Keith Ostashev, Vladimir E. TI Application of the equivalent source method to directional noise sources SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID SOUND-PROPAGATION; RADIATION; ATMOSPHERE AB Prediction of noise levels at long ranges from such sources as flying aircraft or moving ground vehicles is an important practical problem. When terrain, wind, and atmospheric effects are taken into account, this problem cannot be solved analytically, and, thus, numerical solutions are required. There are several numerically efficient algorithms to solve the problem, but, typically, all of them are designed for an omnidirectional point source. Such specification is inadequate for complex and extended sources exhibiting directional radiation patterns. Thus, a method for incorporating directional sound sources into propagation algorithms is needed. This paper describes the equivalent source method (ESM), which enables reconstruction of a compact point-source distribution reproducing a given, arbitrarily complicated, radiation pattern in the far field. The ESM is demonstrated using an asymmetrical surrogate aircraft radiation pattern. Application of the ESM to parabolic equation algorithms is also considered. Some issues of acquisition of input data, such as outliers and data incompleteness, and their adverse effect on source reconstruction are also discussed. (C) 2012 Institute of Noise Control Engineering. C1 [Vecherin, Sergey N.; Wilson, D. Keith; Ostashev, Vladimir E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ostashev, Vladimir E.] Univ Colorado, CIRES, Boulder, CO 80305 USA. RP Vecherin, SN (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sergey.N.Vecherin@usace.army.mil; D.Keith.Wilson@usace.army.mil; vladimir.ostashev@colorado.edu RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU Engineer Research and Development Center (ERDC) Geospatial Research and Engineering business area FX Funding for this work was provided by the Engineer Research and Development Center (ERDC) Geospatial Research and Engineering business area. Sergey Vecherin's work was performed during an appointment to the Postgraduate Research Participation Program at the U. S. Army Cold Regions Research and Engineering Laboratory (CRREL) administrated by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U. S. Department of Energy and CRREL. NR 17 TC 1 Z9 1 U1 0 U2 2 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD MAR PY 2012 VL 60 IS 2 BP 137 EP 147 PG 11 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 925SL UT WOS:000302781400003 ER PT J AU Rangwala, F Putcharoen, O Bowonwatanuwong, C Edwards-Jackson, N Kramomthong, S Kim, JH Corey, GR Ananworanich, J AF Rangwala, Fatima Putcharoen, Opass Bowonwatanuwong, Chureeratana Edwards-Jackson, Nneka Kramomthong, Siriluck Kim, Jerome H. Corey, G. Ralph Ananworanich, Jintanat TI HISTOPLASMOSIS AND PENICILLIOSIS AMONG HIV-INFECTED THAI PATIENTS: A RETROSPECTIVE REVIEW SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Review DE histoplasmosis; penicilliosis; HIV infected patients; review ID ACTIVE ANTIRETROVIRAL THERAPY; INITIATION AB Histoplasmosis and penicilliosis are fungal infections with similar clinical presentation and laboratory findings that were reported mainly in the era prior to highly active antiretroviral therapy. We conducted a retrospective review at two hospitals in Central Thailand of the medical records of HIV-positive patients with microbiologic evidence of histoplasmosis or penicilliosis between January 2003 to September 2007 when anti retrovirals became widely available in Thailand. Fifty patients met inclusion criteria; 36 had histoplasmosis, and 14 had penicilliosis. Symptoms and laboratory findings on presentation were similar between the two infections except for a greater incidence of tachypnea and neutropenia among patients with histoplasmosis (both p < 0.05). For histoplasmosis, blood culture had a significantly lower yield for detecting infection compared to tissue microscopic examination highlighting the importance of obtaining tissue for diagnosis (p < 0.05). C1 [Kim, Jerome H.; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok 10330, Thailand. [Rangwala, Fatima] Duke Univ, Sch Med, Dept Internal Med, Durham, NC USA. [Putcharoen, Opass] King Chulalongkorn Mem Hosp, Fac Med, Dept Med, Div Infect Dis, Bangkok, Thailand. [Bowonwatanuwong, Chureeratana] Minist Publ Hlth, Chon Buri Hosp, Dept Med, Chon Buri, Thailand. [Edwards-Jackson, Nneka] Columbia Univ, Dept Internal Med, New York, NY 10027 USA. [Kramomthong, Siriluck; Kim, Jerome H.; Ananworanich, Jintanat] Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, US Mil HIV Res Program, Rockville, MD USA. [Corey, G. Ralph] Duke Univ, Sch Med, Div Infect Dis, Durham, NC USA. [Corey, G. Ralph] Duke Clin Res Inst, Durham, NC USA. [Ananworanich, Jintanat] HIV Netherlands Australia Thailand Res Collaborar, Bangkok, Thailand. RP Ananworanich, J (reprint author), Thai Red Cross AIDS Res Ctr, SEARCH, 104 Ratchadamri Rd, Bangkok 10330, Thailand. EM jintanat.a@searchthailand.org NR 11 TC 4 Z9 5 U1 0 U2 4 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD MAR PY 2012 VL 43 IS 2 BP 436 EP 441 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 926KD UT WOS:000302829000017 PM 23082594 ER PT J AU Wang, Q Taylor, HA Brunye, TT AF Wang, Qi Taylor, Holly A. Brunye, Tad T. TI When going the right way is hard to do: Distinct phases of action compatibility in spatial knowledge development SO ACTA PSYCHOLOGICA LA English DT Article DE Spatial knowledge development; Embodiment; Action-compatibility effect; Perceptuo-motor integration; Online measure ID REAL-WORLD ENVIRONMENTS; LANGUAGE COMPREHENSION; SIMULATED ACTION; WORKING-MEMORY; MOTOR SYSTEM; REPRESENTATION; DIRECTION; ROUTE; PERSPECTIVE; PERCEPTION AB The present study explores spatial knowledge development using online response measures available in mouse tracking. Online measures can reveal cognitive processing masked in post-processing measures. In the study, participants verified spatial descriptions by moving the mouse to a YES or NO button. Mouse tracking software (Freeman & Ambady, 2010) recorded mouse trajectories. Results demonstrated action-compatibility effects (ACE), differing as a function of spatial knowledge development. For well-developed spatial knowledge, the ACE reflected the physical spatial relationship (e.g. response button on right, but building to the left). In terms of temporal dynamics, this effect occurred later in the response. For less-developed knowledge, the spatial term drove the ACE (e.g., response button on right, but description used term left). In this case, the ACE was immediate and continuous. As would be consistent with learning, ACES were observed more probably with proximal than distant locations. From these results, we infer that perceptuo-motor associations build with time and experience and can play an integral role in retrieval from well-developed spatial representations. (C) 2012 Elsevier B.V. All rights reserved. C1 [Wang, Qi] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, Ctr Dev & Engn, AMSRD NSC WS P, Natick, MA 01760 USA. RP Wang, Q (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM qi.wang@tufts.edu NR 75 TC 5 Z9 5 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-6918 J9 ACTA PSYCHOL JI Acta Psychol. PD MAR PY 2012 VL 139 IS 3 BP 449 EP 457 DI 10.1016/j.actpsy.2012.01.006 PG 9 WC Psychology, Experimental SC Psychology GA 921WL UT WOS:000302508700008 PM 22336560 ER PT J AU Russell, PK Gronvall, GK AF Russell, Philip K. Gronvall, Gigi Kwik TI U.S. MEDICAL COUNTERMEASURE DEVELOPMENT SINCE 2001: A LONG WAY YET TO GO SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID BIOLOGICAL WEAPON; ANTHRAX; PROPHYLAXIS; BIODEFENSE; MANAGEMENT; ADHERENCE; SMALLPOX; VACCINE AB The U.S. government has taken significant steps toward developing and acquiring vaccines, drugs, and other medical countermeasures (MCMs) to protect and treat the population after a biological attack. In contrast to 2001, there is now a procedure for the Department of Health and Human Services (HHS) to develop, license, and stockpile MCMs for civilian use. Another major accomplishment is smallpox preparedness: There is now an adequate supply of vaccine for every person in the U.S., and there is an alternative vaccine meant for immunocompromised people and those with close contact with them. In spite of these and other accomplishments, the U.S. government MCM effort has been criticized by federal advisory committees, National Academy of Sciences reports, a congressional commission, and outside analysts who state that the efforts lack central leadership and accountability and that the pace of progress has been slow. A clear operational strategy for using MCMs, which would guide their development and acquisition, is also lacking. In this article, we review key areas of progress made since 2001 to develop and acquire MCMs, and we summarize what we judge to be the most critical and often mentioned areas where improvements are needed. C1 [Russell, Philip K.] USA, Washington, DC 20310 USA. [Russell, Philip K.] US Dept HHS, Off Res & Dev Coordinat, Off Assistant Secretary Preparedness & Response, Washington, DC 20201 USA. [Gronvall, Gigi Kwik] UPMC, Ctr Biosecur, Baltimore, MD USA. RP Russell, PK (reprint author), USA, Washington, DC 20310 USA. EM PKRUSSELL@aol.com NR 56 TC 6 Z9 7 U1 0 U2 3 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD MAR PY 2012 VL 10 IS 1 BP 66 EP 76 DI 10.1089/bsp.2012.0305 PG 11 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 917ZU UT WOS:000302219400007 PM 22455680 ER PT J AU Le Duc, JW Franz, DR AF Le Duc, James W. Franz, David R. TI GENETICALLY ENGINEERED TRANSMISSIBLE INFLUENZA A/H5N1: A CALL FOR LABORATORY SAFETY AND SECURITY SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Editorial Material C1 [Le Duc, James W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Franz, David R.] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Le Duc, JW (reprint author), Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. EM jwleduc@utmb.edu NR 4 TC 4 Z9 4 U1 1 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD MAR PY 2012 VL 10 IS 1 BP 153 EP 154 DI 10.1089/bsp.2012.0006 PG 2 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 917ZU UT WOS:000302219400016 PM 22313452 ER PT J AU Tomkos, I Kazovsky, L Kitayama, KI AF Tomkos, Ioannis Kazovsky, Leonid Kitayama, Ken-Ichi TI Next-Generation Optical Access Networks: Dynamic Bandwidth Allocation, Resource Use Optimization, and QoS Improvements SO IEEE NETWORK LA English DT Editorial Material DE Optical fibers; Passive optical networks; Next generation networking; Integrated optics; High speed optical techniques C1 [Tomkos, Ioannis] Athens Informat Technol Ctr AIT, Athens, Greece. [Tomkos, Ioannis] Corning Inc, Corning, NY USA. [Tomkos, Ioannis] Univ Athens, GR-10679 Athens, Greece. [Kazovsky, Leonid] Stanford Univ, PNRL, Stanford, CA 94305 USA. [Kazovsky, Leonid] Heinrich Hertz Inst Nachrichtentech Berlin GmbH, Berlin, Germany. [Kazovsky, Leonid] Hewlett Packard Res Labs, Bristol, Avon, England. [Kazovsky, Leonid] Tech Univ Eindhoven, Eindhoven, Netherlands. [Kazovsky, Leonid] Scuola Super St Anne, Pisa, Italy. [Kazovsky, Leonid] Danish Tech Univ, Copenhagen, Denmark. [Kazovsky, Leonid] Acreo, Stockholm, Sweden. [Kitayama, Ken-Ichi] NICT, Commun Res Lab, Tokyo, Japan. [Kitayama, Ken-Ichi] Osaka Univ, Dept Elect Elect & Informat Engn, Grad Sch Engn, Suita, Osaka 565, Japan. USA, Washington, DC USA. EM itom@ait.gr; network.kazovsky@stanford.edu; kitayama@comm.eng.osaka-u.ac.jp RI Tomkos, Ioannis/G-5173-2012 OI Tomkos, Ioannis/0000-0001-9721-3405 NR 0 TC 7 Z9 7 U1 0 U2 14 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0890-8044 J9 IEEE NETWORK JI IEEE Netw. PD MAR-APR PY 2012 VL 26 IS 2 SI SI BP 4 EP 6 DI 10.1109/MNET.2012.6172268 PG 3 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 917XR UT WOS:000302212400002 ER PT J AU Lent, EM Crouse, LCB Quinn, MJ Wallace, SM AF Lent, Emily May Crouse, Lee C. B. Quinn, Michael J., Jr. Wallace, Shannon M. TI Comparison of the Repeated Dose Toxicity of Isomers of Dinitrotoluene SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE dinitrotoluene; toxicity; subacute; Sprague-Dawley rat ID UNSCHEDULED DNA-SYNTHESIS; FISCHER-344 RATS; INVIVO TREATMENT; HEPATOCYTES; GENOTOXICITY; TESTIS AB Dinitrotoluene (DNT) is a nitroaromatic explosive used in propellant mixtures and in the production of plastics. Isomers of DNT were administered daily via oral gavage to male Sprague-Dawley rats for 14 days to determine the subacute toxicity of individual isomers of DNT. The 3,5-DNT isomer was the most toxic isomer, inducing weight loss and mortality within 3 days. Cyanosis and anemia were observed for all isomers. Exposure to 2,4-, 2,6-, and 3,5-DNT resulted in decreased testes mass and degenerative histopathological changes. Increased splenic mass was observed for 2,4-, 2,6-, and 2,5-DNT. Extramedullary hematopoiesis of the spleen was noted for all isomers, while lymphoid hyperplasia of the spleen was noted for all isomers except 2,5-DNT. Increased liver mass was observed for 2,3-DNT and 3,4-DNT. Hepatocellular lesions were observed for 2,6-DNT and 2,4-DNT. Neurotoxic effects were noted for 3,4-DNT, 2,4-DNT, and 3,5-DNT. C1 [Lent, Emily May; Crouse, Lee C. B.; Quinn, Michael J., Jr.; Wallace, Shannon M.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21050 USA. RP Lent, EM (reprint author), US Army Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21050 USA. EM emily.m.lent@us.army.mil FU US Army Environmental Center Installation Restoration Program (MIPR) [MIPRMIPR8BDAT48114, 2008, MIPR9A-DAT48134, 2009] FX The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: funded by the US Army Environmental Center Installation Restoration Program (MIPR numbers MIPRMIPR8BDAT48114, 2008 and MIPR9A-DAT48134, 2009). NR 33 TC 5 Z9 5 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD MAR-APR PY 2012 VL 31 IS 2 BP 143 EP 157 DI 10.1177/1091581811434645 PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 920UR UT WOS:000302434100003 PM 22422434 ER PT J AU Tonwong, N Sattabongkot, J Tsuboi, T Iriko, H Takeo, S Sirichaisinthop, J Udomsangpetch, R AF Tonwong, Natda Sattabongkot, Jetsumon Tsuboi, Takafumi Iriko, Hideyuki Takeo, Satoru Sirichaisinthop, Jeeraphat Udomsangpetch, Rachanee TI Natural Infection of Plasmodium falciparum Induces Inhibitory Antibodies against Gametocyte Development in Human Hosts SO JAPANESE JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID TRANSMISSION-BLOCKING IMMUNITY; MALARIA PARASITES; ANOPHELES-GAMBIAE; STAGE; PROTEIN; DISCOVERY; MOSQUITOS; PFS230 AB We identified naturally induced antibodies from malaria patients in Thailand and clarified the effect of the antibodies on gametocyte development. Fifty-nine percent of the Plasmodium falciparum-infected blood samples (17 of 29) fed to female Anopheles mosquitoes showed no oocyst infection. Seventeen percent of the samples (5 of 29) distorted the morphology and hampered the maturity of the gametocytes. A possible mechanism for the gametocyte inhibitory activity was shown by the binding of the plasma antibodies to live, immature, intraerythrocytic gametocytes during the incubation period. One hundred fifty-seven proteins specific to different gametocyte stages were explored to find the targets of the antisera that bound to the live gametocytes. However, no additional gametocyte transmission- blocking vaccine candidate was detected. Therefore, the development of alternative transmission-blocking vaccines in high-transmission areas should focus on the identification of more gametocyte antigens-inducing inhibitory antibodies that reduce gametocytemia. C1 [Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. [Tonwong, Natda; Udomsangpetch, Rachanee] Mahidol Univ, Fac Med Technol, Dept Parasitol, Bangkok 10400, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Sirichaisinthop, Jeeraphat] Vector Borne Dis Training Ctr, Sara Buri, Thailand. [Udomsangpetch, Rachanee] Ctr Excellence Vectors & Vector Borne Dis, Nakhon Pathom, Thailand. [Tsuboi, Takafumi; Iriko, Hideyuki; Takeo, Satoru] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Iriko, Hideyuki] Tottori Univ, Fac Med, Dept Microbiol & Immunol, Div Med Zool, Tottori 6838503, Japan. RP Udomsangpetch, R (reprint author), Mahidol Univ, Fac Sci, Dept Pathobiol, Rama VI Rd, Bangkok 10400, Thailand. EM scrud@mahidol.ac.th FU Royal Golden Jubilee PhD program, Thailand Research Fund [5TMU45H1] FX This work was supported by the Royal Golden Jubilee PhD program, Thailand Research Fund (5TMU45H1). NR 23 TC 3 Z9 3 U1 1 U2 3 PU NATL INST INFECTIOUS DISEASES PI TOKYO PA JPN J INFECT DIS ED OFF NATL INST INFECTIOUS DISEASES TOYAMA 1-23-1, SHINJUKU-KU, TOKYO, 162-8640, JAPAN SN 1344-6304 EI 1884-2836 J9 JPN J INFECT DIS JI Jpn. J. Infect. Dis. PD MAR PY 2012 VL 65 IS 2 BP 152 EP 156 PG 5 WC Infectious Diseases SC Infectious Diseases GA 922DC UT WOS:000302526000010 PM 22446123 ER PT J AU Weatherhead, PJ Blouin-Demers, G Sperry, JH AF Weatherhead, Patrick J. Blouin-Demers, Gabriel Sperry, Jinelle H. TI Mortality Patterns and the Cost of Reproduction in a Northern Population of Ratsnakes, Elaphe obsoleta SO JOURNAL OF HERPETOLOGY LA English DT Article ID BLACK RATSNAKES; SEXUAL SELECTION; SNAKES; DIMORPHISM; ECOLOGY; TACTICS; ADDERS; SIZE; RISK AB A recent study of Ratsnakes (Elaphe obsoleta) in Texas found that adult mortality was higher for females than males, consistent with the cost of reproduction in snakes being higher for females. To determine whether the same pattern prevailed in a northern population of Ratsnakes, we used data collected using radio-telemetry to test several predictions of the cost-of-reproduction hypothesis. Contrary to there being a cost to reproduction, mortality rates did not differ between juvenile and adult snakes and, contrary to females having a higher cost of reproduction, mortality rates among adults did not differ between males and females. The only evidence consistent with reproduction increasing mortality risk was higher winter mortality for females in poor condition following egg laying. Mortality did not vary with activity but increased with time spent basking, although group differences in basking were not sufficient to produce differences in mortality. High risk of winter mortality in this population may require all Ratsnakes to behave in ways that mask mortality costs associated with reproduction. To determine whether our results for Ratsnakes in Ontario are anomalous or reflect something more substantial about the cost of reproduction in snakes, details of mortality patterns from more species, ideally with diverse ecologies, are needed. C1 [Weatherhead, Patrick J.] Univ Illinois, Program Ecol Evolut & Conservat Biol, Champaign, IL 61820 USA. [Blouin-Demers, Gabriel] Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada. [Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA. RP Weatherhead, PJ (reprint author), Univ Illinois, Program Ecol Evolut & Conservat Biol, 606 E Healey St, Champaign, IL 61820 USA. EM pweather@illinois.edu FU NSERC, Parks Canada; Ontario Ministry of Natural Resources; University of Illinois FX We thank NSERC, Parks Canada, the Ontario Ministry of Natural Resources, and the University of Illinois for funding; Queen's University Biological Station for logistical support; T. Madsen for his comments on the manuscript, and T. J. Benson for statistical advice. NR 30 TC 1 Z9 1 U1 5 U2 29 PU SOC STUDY AMPHIBIANS REPTILES PI ST LOUIS PA C/O ROBERT D ALDRIDGE, ST LOUIS UNIV, DEPT BIOLOGY, 3507 LACLEDE, ST LOUIS, MO 63103 USA SN 0022-1511 J9 J HERPETOL JI J. Herpetol. PD MAR PY 2012 VL 46 IS 1 BP 100 EP 103 DI 10.1670/11-022 PG 4 WC Zoology SC Zoology GA 921BD UT WOS:000302452100018 ER PT J AU Sarney, WL Svensson, SP Hier, H Kipshidze, G Donetsky, D Wang, D Shterengas, L Belenky, G AF Sarney, W. L. Svensson, S. P. Hier, H. Kipshidze, G. Donetsky, D. Wang, D. Shterengas, L. Belenky, G. TI Structural and luminescent properties of bulk InAsSb SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID SEMICONDUCTORS; STRAIN AB The strong bandgap bowing in the InAsxSb1-x alloy system allows it to potentially be used for infrared photodetection in the middle and long wavelength range. The authors have used compositionally graded metamorphic buffer layers to accommodate the misfit strain between InAsxSb1-x alloys and GaSb and InSb substrates in order to reach the long wave infrared range. In this work, we present the characterization of metamorphically grown InAsxSb1-x films that demonstrate strong photoluminescence in the spectral range from 5 to 9 mu m. (C) 2012 American Vacuum Society. [DOI:10.1116/1.3670749] C1 [Sarney, W. L.; Svensson, S. P.; Hier, H.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Kipshidze, G.; Donetsky, D.; Wang, D.; Shterengas, L.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Sarney, WL (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 9 TC 5 Z9 5 U1 0 U2 22 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAR PY 2012 VL 30 IS 2 AR 02B105 DI 10.1116/1.3670749 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 917ZV UT WOS:000302219500005 ER PT J AU Svensson, SP Hier, H Sarney, WL Donetsky, D Wang, D Belenky, G AF Svensson, S. P. Hier, H. Sarney, W. L. Donetsky, D. Wang, D. Belenky, G. TI Molecular beam epitaxy control and photoluminescence properties of InAsBi SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID GROWTH AB Thick InAsBi layers were grown for photoluminescence (PL) characterization. The As to In overpressure ratio was carefully characterized and adjusted to achieve Bi-droplet-free surfaces. A closed loop feedback system was used to maintain the As overpressure during a 5-h deposition sequence. Despite a high degree of control of the growth parameters, evidence for local phase separation was observed in the PL spectra. (C) 2012 American Vacuum Society. [DOI:10.1116/1.3672023] C1 [Svensson, S. P.; Hier, H.; Sarney, W. L.] USA, Res Lab, Adelphi, MD 20783 USA. [Donetsky, D.; Wang, D.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA. RP Svensson, SP (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM stefan.p.svensson.civ@mail.mil NR 11 TC 20 Z9 20 U1 2 U2 33 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAR PY 2012 VL 30 IS 2 AR 02B109 DI 10.1116/1.3672023 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 917ZV UT WOS:000302219500009 ER PT J AU Greenblatt, HM Otto, TC Kirkpatrick, MG Kovaleva, E Brown, S Buchman, G Cerasoli, DM Sussman, JL AF Greenblatt, Harry M. Otto, Tamara C. Kirkpatrick, Melanie G. Kovaleva, Elena Brown, Susan Buchman, George Cerasoli, Douglas M. Sussman, Joel L. TI Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae SO ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS LA English DT Article DE human carboxylesterase 1; whole-insect expression system; Trichoplusia ni ID CRYSTAL-STRUCTURES AB The use of whole insect larvae as a source of recombinant proteins offers a more cost-effective method of producing large quantities of human proteins than conventional cell-culture approaches. Human carboxylesterase 1 has been produced in and isolated from whole Trichoplusia ni larvae. The recombinant protein was crystallized and its structure was solved to 2.2 angstrom resolution. The results indicate that the larvae-produced enzyme is essentially identical to that isolated from cultured Sf21 cells, supporting the use of this expression system to produce recombinant enzymes for crystallization studies. C1 [Greenblatt, Harry M.; Sussman, Joel L.] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel. [Otto, Tamara C.; Kirkpatrick, Melanie G.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Kovaleva, Elena; Brown, Susan; Buchman, George] Chesapeake PERL Inc, Savage, MD 20763 USA. RP Sussman, JL (reprint author), Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel. EM joel.sussman@weizmann.ac.il OI Sussman, Joel/0000-0003-0306-3878 FU Defense Threat Reduction Agency (DTRA) Joint Science and Technology Office, Medical ST Division [HDTRA1-11-C-0026, CBM.SCAV.01.10.RC.017] FX We thank the Israel Structural Proteomics Centre for access to their facilities and Robert Balcerzak for assistance. We gratefully acknowledge financial support from the Defense Threat Reduction Agency (DTRA) Joint Science and Technology Office, Medical S&T Division (Projects HDTRA1-11-C-0026 and CBM.SCAV.01.10.RC.017). JLS is the Pickman Professor of Structural Biology. The views expressed in this manuscript are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the US Government. NR 9 TC 3 Z9 3 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1744-3091 J9 ACTA CRYSTALLOGR F JI Acta Crystallogr. F-Struct. Biol. Cryst. Commun. PD MAR PY 2012 VL 68 BP 269 EP 272 DI 10.1107/S1744309112003326 PN 3 PG 4 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biophysics; Crystallography SC Biochemistry & Molecular Biology; Biophysics; Crystallography GA 914AT UT WOS:000301921300005 PM 22442219 ER PT J AU Sen Tuna, G Braida, W Ogundipe, A Strickland, D AF Sen Tuna, Gulsah Braida, Washington Ogundipe, Adebayo Strickland, David TI Assessing tungsten transport in the vadose zone: From dissolution studies to soil columns SO CHEMOSPHERE LA English DT Article DE Tungsten; Adsorption; Soil lysimeter; Dissolution; Vadose zone AB This study investigates the dissolution, sorption, leachability, and plant uptake of tungsten and alloying metals from canister round munitions in the presence of model, well characterized soils. The source of tungsten was canister round munitions, composed mainly of tungsten (95%) with iron and nickel making up the remaining fraction. Three soils were chosen for the lysimeter studies while four model soils were selected for the adsorption studies. Lysimeter soils were representatives of the typical range of soils across the continental USA; muck-peat, clay-loamy and sandy-quartzose soil. Adsorption equilibrium data on the four model soils were modeled with Langmuir and linear isotherms and the model parameters were obtained. The adsorption affinity of soils for tungsten follows the order: Pahokee peat > kaolinite > montmorillonite > illite. A canister round munition dissolution study was also performed. After 24 d, the measured dissolved concentrations were: 61.97, 3.56, 15.83 mg L-1 for tungsten, iron and nickel, respectively. Lysimeter transport studies show muck peat and sandy quartzose soils having higher tungsten concentration, up to 150 mg kg(-1) in the upper layers of the lysimeters and a sharp decline with depth suggesting strong retardation processes along the soil profile. The concentrations of tungsten, iron and nickel in soil lysimeter effluents were very low in terms of posing any environmental concern; although no regulatory limits have been established for tungsten in natural waters. The substantial uptake of tungsten and nickel by ryegrass after 120 d of exposure to soils containing canister round munition suggests the possibility of tungsten and nickel entering the food chain. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Sen Tuna, Gulsah; Braida, Washington] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. [Ogundipe, Adebayo] James Madison Univ, Harrisonburg, VA 22807 USA. [Strickland, David] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07086 USA. RP Braida, W (reprint author), Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. EM wbraida@stevens.edu FU DOD US Army ARDEC Picatinny Arsenal [W15QKN-05-D-0011, 41] FX This research was supported by the DOD US Army ARDEC Picatinny Arsenal under (Contract No. W15QKN-05-D-0011 #41). The information presented does not necessarily represent the views of the sponsoring agency. NR 21 TC 2 Z9 2 U1 6 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAR PY 2012 VL 86 IS 10 BP 1001 EP 1007 DI 10.1016/j.chemosphere.2011.11.036 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 918UV UT WOS:000302277600005 ER PT J AU Zydel, F Smith, JR Pagnotti, VS Lawrence, RJ McEwen, CN Capacio, BR AF Zydel, Frank Smith, J. Richard Pagnotti, Vincent S. Lawrence, Richard J. McEwen, Charles N. Capacio, Benedict R. TI Rapid screening of chemical warfare nerve agent metabolites in urine by atmospheric solids analysis probe-mass spectroscopy (ASAP-MS) SO DRUG TESTING AND ANALYSIS LA English DT Article DE organophosphorous nerve agent; acetylcholinesterase ID METHYLPHOSPHONIC ACID; SARIN; SAMPLES AB Exposures to organophosphorus nerve agents (OPNA) remain a threat to both civilian and military populations. Verification of exposures typically involves determinations of urinary metabolites or adducted proteins in blood. Urinary alkyl methylphosphonic acid metabolites resulting from hydrolysis of OPNAs provide a convenient marker for OPNA exposure. In a military setting, urine is a relatively easy sample to obtain, and a rapid turnaround for analyses for the identification of metabolites is critical for field commanders. Timely information on use and identity of OPNAs facilitates decisions regarding employment of personal protective equipment and additional strategies to mitigate additional exposure(s). Herein, we report the development of a rapid mass spectrometric (MS) method to identify OPNA metabolites directly from urine with no sample preparation. Synthetic urine spiked with multiple OPNA metabolites was analyzed using an atmospheric solids analysis probe (ASAP) attached to a high resolution mass spectrometer. The alkyl methylphosphonic acid metabolites resulting from hydrolysis of sarin, cyclosarin, soman, and Russian VX were clearly detectable down to a level of 1.0?ng/ml. The ability to rapidly detect OPNA metabolites in unprepared urine allows for the design of a field-deployable device that could afford field personnel the ability to rapidly screen individuals for specific OPNA exposure. In addition, this provides proof-of-concept evidence that a fieldable ASAP-MS device could afford personnel the ability to rapidly detect OPNAs on skin, equipment, and other porous surfaces. Published 2012. This article is a US Government work and is in the public domain in the USA. C1 [Zydel, Frank; Smith, J. Richard; Lawrence, Richard J.; Capacio, Benedict R.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Pagnotti, Vincent S.; McEwen, Charles N.] Univ Sci, Philadelphia, PA USA. RP Zydel, F (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. EM frank.zydel@us.army.mil OI Smith, James/0000-0001-8805-3788 FU Defense Threat Reduction Agency - Joint Science and Technology Office, Medical ST Division; US Army Medical Research Institute of Chemical Defense FX This research was supported in part by an appointment to the Post Graduate Research Participation Program at the US Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC. The views expressed in this article are those of the author(s) and do not reflect the official policy of the Department of Army, Department of Defense, or the US Government. This work was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S&T Division. NR 10 TC 10 Z9 10 U1 2 U2 31 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1942-7603 J9 DRUG TEST ANAL JI Drug Test. Anal. PD MAR-APR PY 2012 VL 4 IS 3-4 SI SI BP 308 EP 311 DI 10.1002/dta.1331 PG 4 WC Biochemical Research Methods; Chemistry, Analytical; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy GA 917DR UT WOS:000302153200019 PM 22383148 ER PT J AU Bhattacharjee, AK Marek, E Le, HT Gordon, RK AF Bhattacharjee, Apurba K. Marek, Elizabeth Ha Thu Le Gordon, Richard K. TI Discovery of non-oxime reactivators using an in silico pharmacophore model of oxime reactivators of OP-inhibited acetylcholinesterase SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article DE In silico pharmacophore model; Virtual screening; Non-oxime reactivators; DFP-inhibited AChE ID BLOOD-BRAIN-BARRIER; N-METHYLPYRIDINIUM-2-CARBALDOXIME CHLORIDE; CHOLINESTERASE REACTIVATORS; BIOLOGICAL-MEMBRANES; ALZHEIMERS-DISEASE; CRYSTAL-STRUCTURES; IMPROVED DELIVERY; DRUG DISCOVERY; PRO-DRUG; TABUN AB We earlier reported an in silico pharmacophore model for reactivation of oximes to tabun-inhibited AChE. Since DFP (diisopropylfluorophosphate) like tabun is a G-agent simulator, we utilized the model as a rational strategy to discover non-oxime reactivators of DFP-inhibited AChE in this study. The phramacophore was used for virtual screening of two commercial databases, Maybridge and ChemNavigator, to identify reactivators which lack the oxime functions. The procedure led us to identify several potent non-oxime compounds that reactivate DFP-inhibited AChE. These non-oxime reactivators contain a nucleophile group in lieu of the oxime moiety in the compound. Five of these novel non-oximes showed Kr values within ten-fold of 2-PAM in an in vitro assay. The pharmacophore model contained a hydrogen bond acceptor, a hydrogen bond donor, and an aromatic ring features distributed in a 3D space. Calculated stereoelectronic properties reported earlier with respect to the location of molecular orbitals and electrostatic potentials were consistent with the model and the newly identified compounds. Down selection of compounds after virtual screening was performed on the basis of fit score to the model, conformational energy, and in silico evaluations for favorable blood-brain barrier (BBB) penetrability, octanol-water partition (log P), and toxicity (rat oral LD50) assessments. In vitro reactivation efficacy of the compounds was evaluated in a DFP-inhibited eel acetylcholinesterase assay. (C) 2012 Published by Elsevier Masson SAS. C1 [Bhattacharjee, Apurba K.; Marek, Elizabeth; Ha Thu Le; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, Silver Spring, MD 20910 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM apurba.bhattacharjee@amedd.army.mil; Richard.k.gordon@us.army.mil FU DTRA [1E0057_08_WR_C] FX This material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or reflecting true views of the Department of the Army or the Department of Defense. Funding from DTRA (#1E0057_08_WR_C) is acknowledged. NR 58 TC 12 Z9 13 U1 4 U2 13 PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER PI PARIS PA 23 RUE LINOIS, 75724 PARIS, FRANCE SN 0223-5234 J9 EUR J MED CHEM JI Eur. J. Med. Chem. PD MAR PY 2012 VL 49 BP 229 EP 238 DI 10.1016/j.ejmech.2012.01.016 PG 10 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 915ND UT WOS:000302033300023 PM 22309910 ER PT J AU Sawka, MN Cheuvront, SN Kenefick, RW AF Sawka, Michael N. Cheuvront, Samuel N. Kenefick, Robert W. TI High skin temperature and hypohydration impair aerobic performance SO EXPERIMENTAL PHYSIOLOGY LA English DT Article ID MUSCLE BLOOD-FLOW; PROLONGED EXERCISE; HEAT-STRESS; CARDIOVASCULAR DRIFT; ENDURANCE CAPACITY; BODY-TEMPERATURE; TWIST MECHANICS; STROKE VOLUME; HYPERTHERMIA; HUMANS AB This paper reviews the roles of hot skin (>35 degrees C) and body water deficits (>2% body mass; hypohydration) in impairing submaximal aerobic performance. Hot skin is associated with high skin blood flow requirements and hypohydration is associated with reduced cardiac filling, both of which act to reduce aerobic reserve. In euhydrated subjects, hot skin alone (with a modest core temperature elevation) impairs submaximal aerobic performance. Conversely, aerobic performance is sustained with core temperatures >40 degrees C if skin temperatures are cool-warm when euhydrated. No study has demonstrated that high core temperature (similar to 40 degrees C) alone, without coexisting hot skin, will impair aerobic performance. In hypohydrated subjects, aerobic performance begins to be impaired when skin temperatures exceed 27 degrees C, and even warmer skin exacerbates the aerobic performance impairment (1.5% for each 1 degrees C skin temperature). We conclude that hot skin (high skin blood flow requirements from narrow skin temperature to core temperature gradients), not high core temperature, is the primary factor impairing aerobic exercise performance when euhydrated and that hypohydration exacerbates this effect. C1 [Sawka, Michael N.; Cheuvront, Samuel N.; Kenefick, Robert W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA. EM robert.kenefick@us.army.mil NR 48 TC 47 Z9 47 U1 3 U2 24 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0958-0670 J9 EXP PHYSIOL JI Exp. Physiol. PD MAR PY 2012 VL 97 IS 3 BP 327 EP 332 DI 10.1113/expphysiol.2011.061026 PG 6 WC Physiology SC Physiology GA 900GB UT WOS:000300873500008 PM 22143882 ER PT J AU Durham, B Grodowitz, MJ AF Durham, Brian Grodowitz, Michael J. TI THE ANAL PLATES OF LARVAL HYDRELLIA PAKISTANAE (DIPTERA: EPHYDRIDAE) SO FLORIDA ENTOMOLOGIST LA English DT Article DE Hydrellia pakistanae; anal plates; anal organ; osmoregulation; silver nitrate; epithelia cells ID MUSCA-DOMESTICA LARVAE; HYDROCHARITACEAE; ESTABLISHMENT; ORGAN AB The objective of this research was to describe the anal plates of the larval stages of the ephydrid fly, Hydrellia pakistanae Deonier, a biological control agent of hydrilla (Hydrilla verticillata (L.f.) Royle). This was accomplished using light microscopy coupled with a specialized staining technique; and scanning electron microscopy (SEM). All 3 instars of H. pakistanae were collected from hydrilla cultured in outdoor concrete-lined ponds. To ascribe a function to the anal plates, a modified staining technique was employed that uses a 5% silver nitrate solution, which, upon ionization, binds with chloride ions suggesting an osmoregulatory function. Under light microscopy the two anal plates appeared smooth, flat crescent moon-shaped structures that encircled the anus of the larva. SEM revealed the anal plates to be relatively smooth with an undulating surface pattern possibly an artifact of the high vacuum conditions associated with the SEM. This may therefore indicate a difference in cuticle thickness for the anal plates since the overall body cuticle did not exhibit the same surface changes. A distinct delineation in the form of a thin raised line of cuticle between the anal plates and the outer body cuticle could be discerned from both light microscopy and SEM. The anal plates vary in size from 200 mu m to 750 mu m in perimeter and 1800 mu m(2) to 14000 mu m(2) in area depending on instar. A highly positive correlation in anal plate size in relation to larval instar was also detected; i.e., larger anal plates were associated with later instars. The anal plates darkened rapidly after immersion in a weak silver nitrate solution with subsequent exposure to light indicating that they may play an important role in maintaining internal ionic equilibrium. C1 [Durham, Brian; Grodowitz, Michael J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Durham, B (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 22 TC 0 Z9 0 U1 0 U2 2 PU FLORIDA ENTOMOLOGICAL SOC PI LUTZ PA 16125 E LAKE BURRELL DR, LUTZ, FL 33548 USA SN 0015-4040 J9 FLA ENTOMOL JI Fla. Entomol. PD MAR PY 2012 VL 95 IS 1 BP 82 EP 88 PG 7 WC Entomology SC Entomology GA 913HF UT WOS:000301867000013 ER PT J AU Weiss, CV Zhang, J Spies, M Abdallah, LS Zollner, S Cole, MW Alpay, SP AF Weiss, C. V. Zhang, J. Spies, M. Abdallah, L. S. Zollner, S. Cole, M. W. Alpay, S. P. TI Bulk-like dielectric properties from metallo-organic solution-deposited SrTiO3 films on Pt-coated Si substrates SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TITANATE THIN-FILMS; CHEMICAL SOLUTION DEPOSITION; ELECTRICAL-PROPERTIES; DEVICE APPLICATIONS; PRECURSOR SOLUTION; STRAIN; FERROELECTRICITY; FABRICATION; CAPACITORS; MORPHOLOGY AB SrTiO3 (STO) thin films were grown onto Pt/Ti/TiO2/SiO2/Si and bare Si substrates via metallo-organic solution deposition (MOSD). X ray diffraction, scanning electron microscopy, atomic force microscopy, spectroscopic ellipsometry (SE), and dielectric/insulating measurements were utilized to characterize the STO thin films. By optimizing the solution molarity, it is shown that it is possible to obtain low-frequency dielectric properties in STO thin films on Si substrates that approach those of bulk STO: a dielectric permittivity of 325 at 100 kHz with a tunability of similar to 28% at similar to 650 kV/cm, a low loss (<2%), and a leakage current density of 1.0 x 10(-6) A/cm(2) at 100 kV/cm. The bulk-like dielectric response of these films is attributed to the elimination of the relatively large in-plane tensile thermal stresses, which arise due to the thermal expansion mismatch between the STO film and the Si substrate. These tensile thermal stresses may be relaxed or completely eliminated through modification of the post-coalescence compressive growth stresses by precursor solution optimization. The SE data indicates that the STO thin films have a refractive index of similar to 2.04 at 633 nm wavelength, which is lower than that of bulk STO. The dielectric, physical, and optical characterization results above the bandgap are consistent, but below the bandgap, the optical-frequency results demonstrate a similar to 25% reduced dielectric response as compared to the bulk, which may be due to the different polarization mechanisms at work at high frequencies. These findings demonstrate that high-quality, electronic-grade, thin film STO films can be grown on Si substrates via the affordable, simple, and industry-standard MOSD technique by carefully adjusting the deposition parameters. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.3692811] C1 [Weiss, C. V.; Zhang, J.; Alpay, S. P.] Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. [Weiss, C. V.; Zhang, J.; Alpay, S. P.] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. [Spies, M.; Abdallah, L. S.; Zollner, S.] New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. [Cole, M. W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Alpay, SP (reprint author), Univ Connecticut, Mat Sci & Engn Program, Storrs, CT 06269 USA. EM p.alpay@ims.uconn.edu RI Alpay, Pamir/E-2666-2013; Zollner, Stefan/B-4858-2012 OI Zollner, Stefan/0000-0001-7752-7941 FU OSD-T&E (Office of Secretary of Defense - Test and Evaluation); Defense National Defense Education [Wide/PE0601120D8Z]; National Science Foundation [DMR-1104934]; [N00244-09-1-0081] FX This research was partially funded by OSD-T&E (Office of Secretary of Defense - Test and Evaluation), Defense Wide/PE0601120D8Z National Defense Education Program (NDEP)/BA-1, Basic Research - Grant Number N00244-09-1-0081. The work at NMSU was supported in part by the National Science Foundation (DMR-1104934). NR 57 TC 12 Z9 12 U1 1 U2 24 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 1 PY 2012 VL 111 IS 5 AR 054108 DI 10.1063/1.3692811 PG 9 WC Physics, Applied SC Physics GA 911OW UT WOS:000301729200106 ER PT J AU Tabak, B Elliott, CL Mahnke, CB Tanaka, LY Ogino, MT AF Tabak, Benjamin Elliott, Christopher L. Mahnke, C. Becket Tanaka, Len Y. Ogino, Mark T. TI Transthoracic echocardiography visualization of bicaval dual lumen catheters for veno-venous extracorporeal membrane oxygenation SO JOURNAL OF CLINICAL ULTRASOUND LA English DT Article DE transthoracic echocardiography; extracorporeal membrane oxygenation (ECMO); dual lumen catheter ID CANNULA PLACEMENT AB Bicaval dual lumen catheters improve the efficiency of veno-venous extracorporeal membrane oxygenation by minimizing recirculation with an innovative design, which requires precise placement of three catheter ports in the superior vena cava, right atrium, and inferior vena cava, respectively. However, the exact position of these catheter ports is usually not known during placement because they cannot be visualized with conventional radiography. We performed a retrospective review of our experience over the past year using transthoracic echocardiography to evaluate the position of the catheter ports. From a subcostal, sagittal imaging approach, we were able to identify all three catheter ports in 11 of 11 studies. At least one of the catheter ports was incorrectly positioned in 5 of 11 studies. Further prospective evaluation is necessary to determine if catheter repositioning based on transthoracic echocardiography findings can further improve the clinical efficiency of veno-venous extracorporeal membrane oxygenation. (c) 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2012. C1 [Tabak, Benjamin; Elliott, Christopher L.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. [Mahnke, C. Becket] Tripler Army Med Ctr, Dept Pediat Cardiol, Honolulu, HI 96859 USA. [Tanaka, Len Y.] Kapiolani Med Ctr Women & Children, Dept Pediat, Honolulu, HI 96826 USA. [Ogino, Mark T.] Univ Penn, Sch Med, Dept Pediat Neonatol, Philadelphia, PA 19102 USA. [Ogino, Mark T.] Univ Hawaii, Hanuola ECMO Program Hawaii, John A Burns Sch Med, Honolulu, HI 96813 USA. RP Tabak, B (reprint author), Tripler Army Med Ctr, Dept Gen Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. FU Department of Defense (DoD) [W81XWH-06-2-0061] FX This work was supported by Department of Defense (DoD) Grant No. W81XWH-06-2-0061. The opinions expressed in the article are those solely of the authors and do not represent the views or official policies of the United States Army, Department of Defense, or United States Government NR 7 TC 9 Z9 9 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0091-2751 J9 J CLIN ULTRASOUND JI J. Clin. Ultrasound PD MAR-APR PY 2012 VL 40 IS 3 BP 183 EP 186 DI 10.1002/jcu.21873 PG 4 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 903JD UT WOS:000301111600010 PM 22238069 ER PT J AU Reiter, M Schwope, R Walker, K Suhr, A AF Reiter, Michael Schwope, Ryan Walker, Kyle Suhr, Abraham TI Imaging of Glaucoma Drainage Devices SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE glaucoma drainage device; glaucoma implant; CT; radiographs ID IMPLANTS AB Previously reserved for patients with refractory glaucoma, glaucoma drainage devices (GDDs) are being used more frequently as a primary treatment option. Several types of GDDs are currently manufactured, only one of which is radiopaque. Knowledge of their typical imaging appearance in addition to pertinent background information is therefore vital for radiologists. We present a case of bilateral glaucoma drainage devices and briefly review the surgical aspect of implantation. C1 [Reiter, Michael; Schwope, Ryan; Walker, Kyle] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA. [Suhr, Abraham] Brooke Army Med Ctr, Dept Ophthalmol, San Antonio, TX 78234 USA. RP Reiter, M (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM michael.reiter1@us.army.mil NR 7 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAR-APR PY 2012 VL 36 IS 2 BP 277 EP 279 DI 10.1097/RCT.0b013e31824afda8 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 916ZN UT WOS:000302141800023 PM 22446374 ER PT J AU Taylor, CL Eckart, RE AF Taylor, Charles L. Eckart, Robert E. TI CHEST PAIN, ST ELEVATION, AND POSITIVE CARDIAC ENZYMES IN AN AUSTERE ENVIRONMENT: DIFFERENTIATING SMALLPOX VACCINATION-MEDIATED MYOCARDITIS AND ACUTE CORONARY SYNDROME IN OPERATION IRAQI FREEDOM SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE Smallpox; vaccination; myocarditis; immunization; Global War on Terrorism ID LYMPHOCYTIC MYOCARDITIS; CLINICAL PRESENTATION; INFARCTION; MYOPERICARDITIS AB Background: Myocarditis is a recognized but rare complication of smallpox immunization. It typically presents within 30 days of immunization and on initial presentation shares many characteristics with acute coronary syndrome. Electrocardiogram findings, elevated cardiac enzymes, and undifferentiated chest pain require immediate implementation of therapy directed towards an acute coronary syndrome. In an austere environment, access to advanced care may be limited. Objectives: Smallpox vaccine-mediated myocarditis may present, typically within 30 days of immunization, in such a fashion that it is impossible to distinguish from acute myocardial infarction. The purpose of this article is to alert the clinician to this problem and to provide information to assist in making a suitable diagnosis and disposition in the absence of an absolute diagnosis. Case Report: We present a case of smallpox vaccine-associated myocarditis in an American serviceman deployed in Iraq, and review the literature to determine management of these cases in an emergency setting. Conclusions: This case serves to increase awareness of the association of vaccine-mediated myocarditis in the month after immunization, and the fact that it may present similar to infarction. If the clinical probability of myocarditis is greater than infarction, this will lead the clinician to different treatment modalities. Published by Elsevier Inc. C1 [Taylor, Charles L.] 10th Special Forces Grp, Dept Emergency Med, Ft Carson, CO 80913 USA. [Eckart, Robert E.] Brooke Army Med Ctr, Div Cardiol, Ft Sam Houston, TX 78234 USA. RP Taylor, CL (reprint author), 10th Special Forces Grp, Dept Emergency Med, Ft Carson, CO 80913 USA. NR 18 TC 1 Z9 1 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD MAR PY 2012 VL 42 IS 3 BP 267 EP 270 DI 10.1016/j.jemermed.2008.08.027 PG 4 WC Emergency Medicine SC Emergency Medicine GA 918SX UT WOS:000302272500004 PM 19181475 ER PT J AU Grujicic, M Bell, WC Pandurangan, B Cheeseman, BA Patel, P Gazonas, GA AF Grujicic, M. Bell, W. C. Pandurangan, B. Cheeseman, B. A. Patel, P. Gazonas, G. A. TI Inclusion of material non-linearity and inelasticity into a continuum-level material model for soda-lime glass SO MATERIALS & DESIGN LA English DT Article DE Glasses; Fracture; Modeling ID BRITTLE MATERIALS; DAMAGE; FRAGMENTATION; PRESSURE; SOLIDS; SILICA AB Numerous experimental investigations clearly established that when soda-lime glass is subjected to sufficiently high axial-stress/pressure, it displays a nonlinear mechanical response and deformation irreversibility (inelasticity). This portion of the material behavior is often neglected in material models for glass which tend to focus on the damage and fracture phenomena of the material. However, material nonlinearity/inelasticity can, in principle, have a profound effect on wave/shock propagation phenomena and processes (e. g. spall fracture). Within the present work, the effect of material nonlinearity and inelastic behavior on the dynamic response (including spallation) of soda-lime glass is studied under symmetric flyer-plate loading conditions using computational methods and tools. Material nonlinearity and deformation irreversibility are modeled in two different ways: (a) as a non-linear elastic material response with no deformation irreversibility; and (b) as a linear-elastic, volumetrically-plastic deformation response. Incorporation of nonlinearity and inelasticity phenomena into a continuum-level material model for soda-lime glass recently developed by the authors revealed that while these phenomena do not measurably affect spall resistance (as measured by a minimum flyer-plate velocity resulting in spallation), they provide beneficial linear-momentum/kinetic energy reduction effects. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Grujicic, M.; Bell, W. C.; Pandurangan, B.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Patel, P.; Gazonas, G. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM gmica@clemson.edu OI Gazonas, George/0000-0002-2715-016X FU US Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; Army Research Office (ARO) [W911NF-09-1-0513] FX The material presented in this paper is based on work supported by the US Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042 and by the Army Research Office (ARO) research contract entitled "Multi-length Scale Material Model Development for Armor-grade Composites", Contract Number W911NF-09-1-0513. NR 33 TC 10 Z9 10 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-1275 EI 1873-4197 J9 MATER DESIGN JI Mater. Des. PD MAR PY 2012 VL 35 BP 144 EP 155 DI 10.1016/j.matdes.2011.08.031 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA 909QG UT WOS:000301578700020 ER PT J AU Wang, Y Oguntayo, S Wei, YL Wood, E Brown, A Jensen, N Auta, J Guiodotti, A Doctor, BP Nambiar, MP AF Wang, Ying Oguntayo, Samuel Wei, Yanling Wood, Elisa Brown, Ammon Jensen, Neil Auta, James Guiodotti, Alessandro Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Neuroprotective effects of imidazenil against chemical warfare nerve agent soman toxicity in guinea pigs SO NEUROTOXICOLOGY LA English DT Article DE Soman; Imidazenil; Neuroprotection; Seizure; Neuropathology; Guinea pig ID DIISOPROPYL FLUOROPHOSPHATE TOXICITY; POSITIVE ALLOSTERIC MODULATOR; INDUCED BRAIN-DAMAGE; INDUCED SEIZURES; GABA(A) RECEPTORS; INDUCED NEUROPATHOLOGY; ANTICONVULSANT ACTION; STATUS-EPILEPTICUS; CARDIAC PATHOLOGY; RAT HIPPOCAMPUS AB The chemical warfare nerve agent, soman irreversibly inhibits acetylcholinesterase (AChE) leading to hypercholinergy and seizures which trigger glutamate toxicity and status epilepticus ultimately resulting in neuropathology and neurobehavioral deficits. The standard emergency treatment comprising of anticholinergic, AChE reactivator and anticonvulsant does not completely protect against soman toxicity. We have evaluated imidazenil, a new anticonvulsant imidazo benzodiazepine with high affinity and intrinsic efficacy at alpha 5-, alpha 2-, and alpha 3- but low intrinsic efficacy at alpha 1-containing GABA(A) receptors and is devoid of cardiorespiratory depression, sedative/hypnoitc and amnestic actions and does not elicit tolerance and dependence liabilities unlike diazepam, for protection against soman toxicity. Guinea pigs implanted with bipotential radiotelemetry probes for recording EEG and ECG were administered with 26 mu g/kg pyridostigmine bromide 30 min prior to 2 x LD50 soman exposure and 1 min later treated with a combination of 2 mg/kg atropine sulfate and 25 mg/kg 2-pralidoxime and various doses of imidazenil. Intramuscular administration of imidazenil, dose-dependently protected against 2x LD50 of soman toxicity up to 1 mg/kg. Further increase in the dose of imidazenil to 2.5 mg/kg was less effective than 1 mg/kg probably due to non-specific actions at sites other than GABA(A) receptors. Compared to vehicle group, 1 mg/kg imidazenil treatment showed optimal increase in survival rate, reduction in behavioral manifestations and high power of EEG spectrum as well as neuronal necrosis. These data suggest that imidazenil is an effective anticonvulsant for medical countermeasure against soman-induced toxicity. Published by Elsevier Inc. C1 [Wang, Ying; Oguntayo, Samuel; Wei, Yanling; Wood, Elisa; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Brown, Ammon] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. [Jensen, Neil] USA, Collaborat Res Facil, Med Res Inst Chem Def, Edgewood, MD USA. [Auta, James; Guiodotti, Alessandro] Univ Illinois, Inst Psychiat, Chicago, IL USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@us.army.mil FU Defense Threat Reduction Agency (DTRA) [1.E0003_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant #1.E0003_08_WR_C. The technical assistance from the Collaborative Research Facility, USAMRICD is greatly acknowledged. NR 67 TC 2 Z9 3 U1 2 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD MAR PY 2012 VL 33 IS 2 BP 169 EP 177 DI 10.1016/j.neuro.2011.12.018 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 913SK UT WOS:000301897500004 PM 22245390 ER PT J AU Mire, CE Miller, AD Carville, A Westmoreland, SV Geisbert, JB Mansfield, KG Feldmann, H Hensley, LE Geisbert, TW AF Mire, Chad E. Miller, Andrew D. Carville, Angela Westmoreland, Susan V. Geisbert, Joan B. Mansfield, Keith G. Feldmann, Heinz Hensley, Lisa E. Geisbert, Thomas W. TI Recombinant Vesicular Stomatitis Virus Vaccine Vectors Expressing Filovirus Glycoproteins Lack Neurovirulence in Nonhuman Primates SO PLOS NEGLECTED TROPICAL DISEASES LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; MARBURG HEMORRHAGIC-FEVER; EBOLA-VIRUS; MEASLES-VIRUS; COMPLETE PROTECTION; POSTEXPOSURE PROTECTION; REPLICATION-COMPETENT; MUCOSAL IMMUNIZATION; CYNOMOLGUS MACAQUES; GUINEA-PIGS AB The filoviruses, Marburg virus and Ebola virus, cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular stomatitis virus (rVSV) that expresses an individual filovirus glycoprotein (GP) in place of the VSV glycoprotein (G). The main concern with all replication-competent vaccines, including the rVSV filovirus GP vectors, is their safety. To address this concern, we performed a neurovirulence study using 21 cynomolgus macaques where the vaccines were administered intrathalamically. Seven animals received a rVSV vector expressing the Zaire ebolavirus (ZEBOV) GP; seven animals received a rVSV vector expressing the Lake Victoria marburgvirus (MARV) GP; three animals received rVSV-wild type (wt) vector, and four animals received vehicle control. Two of three animals given rVSV-wt showed severe neurological symptoms whereas animals receiving vehicle control, rVSV-ZEBOV-GP, or rVSV-MARV-GP did not develop these symptoms. Histological analysis revealed major lesions in neural tissues of all three rVSV-wt animals; however, no significant lesions were observed in any animals from the filovirus vaccine or vehicle control groups. These data strongly suggest that rVSV filovirus GP vaccine vectors lack the neurovirulence properties associated with the rVSV-wt parent vector and support their further development as a vaccine platform for human use. C1 [Mire, Chad E.; Geisbert, Joan B.; Geisbert, Thomas W.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. [Mire, Chad E.; Geisbert, Joan B.; Geisbert, Thomas W.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX USA. [Miller, Andrew D.; Carville, Angela; Westmoreland, Susan V.; Mansfield, Keith G.] Harvard Univ, Sch Med, Boston, MA USA. [Miller, Andrew D.; Westmoreland, Susan V.] New England Primate Res Ctr, Div Comparat Pathol, Southborough, MA USA. [Carville, Angela] New England Primate Res Ctr, Dept Pathol, Southborough, MA USA. [Mansfield, Keith G.] New England Primate Res Ctr, Div Primate Resources, Southborough, MA USA. [Feldmann, Heinz] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT USA. [Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Mire, CE (reprint author), Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA. EM lisa.hensley@us.army.mil FU Defense Threat Reduction Agency; US Army Medical Research Acquisition [W81XWH-08-C-0765] FX This study was funded in part by the Defense Threat Reduction Agency, US Army Medical Research Acquisition contract no. W81XWH-08-C-0765 to TWG. The funding agency had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 68 TC 34 Z9 36 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1935-2727 J9 PLOS NEGLECT TROP D JI Plos Neglect. Trop. Dis. PD MAR PY 2012 VL 6 IS 3 AR e1567 DI 10.1371/journal.pntd.0001567 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 916VU UT WOS:000302132100021 PM 22448291 ER PT J AU Linkov, I Cormier, S Gold, J Satterstrom, FK Bridges, T AF Linkov, Igor Cormier, Susan Gold, Joshua Satterstrom, F. Kyle Bridges, Todd TI Using Our Brains to Develop Better Policy SO RISK ANALYSIS LA English DT Article DE Environmental policy; neuroeconomics; risk analysis ID MULTICRITERIA DECISION-ANALYSIS; COMPARATIVE RISK-ASSESSMENT; SENSORY STIMULI; MANAGEMENT AB Current governmental practices often use a method called weight of evidence (WoE) to integrate and weigh different sources of information in the process of reaching a decision. Recent advances in cognitive neuroscience have identified WoE-like processes in the brain, and we believe that these advances have the potential to improve current decision-making practices. In this article, we describe five specific areas where knowledge emerging from cognitive neuroscience may be applied to the challenges confronting decisionmakers who manage risks: (1) quantifying evidence, (2) comparing the value of different sources of evidence, (3) reaching a decision, (4) illuminating the role of subjectivity, and (5) adapting to new information. We believe that the brain is an appropriate model for structuring decision-making processes because the brain's network is designed for complex, flexible decision making, and because policy decisions that must ultimately depend on human judgment will be best served by methods that complement human abilities. Future discoveries in cognitive neuroscience will likely bring further applications to decision practice. C1 [Linkov, Igor; Bridges, Todd] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Cormier, Susan] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Gold, Joshua] Univ Penn, Dept Neurosci, Philadelphia, PA 19104 USA. [Satterstrom, F. Kyle] Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. RP Linkov, I (reprint author), USA, Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA 02446 USA. EM Igor.Linkov@usace.army.mil FU Dredging Operation Environmental Research (DOER) FX This work was supported in part by the Dredging Operation Environmental Research (DOER). Permission was granted by the USACE Chief of Engineers to publish this material. The article has been reviewed and cleared by the U.S. EPA, but does not necessarily reflect Agency policies. NR 35 TC 6 Z9 8 U1 4 U2 18 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD MAR PY 2012 VL 32 IS 3 BP 374 EP 380 DI 10.1111/j.1539-6924.2011.01683.x PG 7 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 906KU UT WOS:000301344800005 PM 22023503 ER PT J AU Wallgren, S Berry-Caban, CS Bowers, L AF Wallgren, Stephanie Berry-Caban, Cristobal S. Bowers, Laura TI Impact of Clinical Pharmacist Intervention on Diabetes-Related Outcomes in a Military Treatment Facility SO ANNALS OF PHARMACOTHERAPY LA English DT Article DE ADA treatment goals; clinical pharmacist; diabetes ID RANDOMIZED CONTROLLED-TRIAL; BLOOD-GLUCOSE CONTROL; COMPLICATIONS; MANAGEMENT; MELLITUS; RISK AB BACKGROUND: Clinical pharmacist management of patients with diabetes has been well justified, but there is a lack of research that evaluates the impact of pharmacist-managed diabetes care versus standard medical care on American Diabetes Association (ADA) treatment goals other than hemoglobin A(1c) (A1C). OBJECTIVE: To evaluate the reduction in A1C, blood pressure, and low-density lipoprotein cholesterol (LDL-C) for patients with diabetes whose care was managed by a clinical pharmacist and compare these values to those of a cohort of patients whose care was managed by primary care providers. The difference in percentage of patients attaining ADA treatment goals between the 2 groups was also evaluated. METHODS: This retrospective chart review identified 98 diabetic patients managed by a clinical pharmacist with at least 2 A1C measurements between September 15, 2008, and March 15, 2011. The Military Health System Population Health Portal was used to identify a similar group of patients with diabetes managed by their primary care provider (N = 90). The Armed Forces Health Longitudinal Technology Application was used to collect baseline data and the most recent measurements for A1C, blood pressure, LDL-C, and documented immunizations. RESULTS: The pharmacist group saw positive improvements in all primary end points, including a 1.6% reduction in A1C, a 9-mm Hg and 1.4-mm Hg reduction in systolic and diastolic blood pressure, respectively, and a 16.3-mg/dL reduction in LDL-C. Conversely, the control group had an increase of 0.8% in A1C and 1.5 mm Hg in diastolic blood pressure. Reductions in systolic blood pressure and LDL-C were much less robust than in the pharmacist group (1.6 mm Hg and 5.2 mg/dL, respectively). Overall, patients in the pharmacist group were more likely to achieve ADA treatment goals. CONCLUSION: Pharmacist management of patients with diabetes significantly reduces A1C and allows more patients to meet ADA treatment goals. A clinical pharmacist run diabetes clinic can provide numerous clinical benefits to patients. C1 [Wallgren, Stephanie; Bowers, Laura] Womack Army Med Ctr, Dept Pharm, Ft Bragg, NC 28307 USA. [Berry-Caban, Cristobal S.] Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA. RP Wallgren, S (reprint author), Womack Army Med Ctr, Dept Pharm, Ft Bragg, NC 28307 USA. EM stephanie.a.wallgren@us.army.mil NR 11 TC 7 Z9 7 U1 0 U2 4 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 USA SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD MAR PY 2012 VL 46 IS 3 BP 353 EP 357 DI 10.1345/aph.1Q564 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 915CB UT WOS:000301999400005 PM 22395249 ER PT J AU Badu, K Afrane, YA Larbi, J Stewart, VA Waitumbi, J Angov, E Ong'echa, JM Perkins, DJ Zhou, G Githeko, A Yan, G AF Badu, Kingsley Afrane, Yaw Asare Larbi, John Stewart, Virginia Ann Waitumbi, John Angov, Evelina Ong'echa, John M. Perkins, Douglas J. Zhou, Guofa Githeko, Andrew Yan, Guiyun TI Marked variation in MSP-1(19) antibody responses to malaria in western Kenyan highlands SO BMC INFECTIOUS DISEASES LA English DT Article ID MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM TRANSMISSION; TREATED BED NETS; ESCHERICHIA-COLI; INFECTION; EXPOSURE; AREA; CHILDREN; PREVALENCE; ANTIGENS AB Background: Assessment of malaria endemicity at different altitudes and transmission intensities, in the era of dwindling vector densities in the highlands, will provide valuable information for malaria control and surveillance. Measurement of serum anti-malarial antibodies is a useful marker of malaria exposure that indicates long-term transmission potential. We studied the serologic evidence of malaria endemicity at two highland sites along a transmission intensity cline. An improved understanding of the micro-geographic variation in malaria exposure in the highland ecosystems will be relevant in planning effective malaria control. Methods: Total IgG levels to Plasmodium falciparum MSP-1(19) were measured in an age-stratified cohort (< 5, 5-14 and >= 15 years) in 795 participants from an uphill and valley bottom residents during low and high malaria transmission seasons. Antibody prevalence and level was compared between different localities. Regression analysis was performed to examine the association between antibody prevalence and parasite prevalence. Age-specific MSP-1(19) seroprevalence data was fitted to a simple reversible catalytic model to investigate the relationship between parasite exposure and age. Results: Higher MSP-1(19) seroprevalence and density were observed in the valley residents than in the uphill dwellers. Adults (> 15 years) recorded high and stable immune response in spite of changing seasons. Lower responses were observed in children (<= 15 years), which, fluctuated with changing seasons particularly in the valley residents. In the uphill population, annual seroconversion rate (SCR) was 8.3% and reversion rate was 3.0%, with seroprevalence reaching a plateau of 73.3% by age of 20. Contrary, in the valley bottom population, the annual SCR was 35.8% and the annual seroreversion rate was 3.5%, and seroprevalence in the population had reached 91.2% by age 10. Conclusion: The study reveals the micro-geographic variation in malaria endemicity in the highland eco-system; this validates the usefulness of sero-epidemiological tools in assessing malaria endemicity in the era of decreasing sensitivity of conventional tools. C1 [Badu, Kingsley; Afrane, Yaw Asare; Githeko, Andrew] Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. [Badu, Kingsley; Larbi, John] Univ Sci & Technol, Coll Sci, Dept Theoret & Appl Biol, Kumasi, Ghana. [Stewart, Virginia Ann; Waitumbi, John] USA, Walter Reed Project, Med Res Unit Kisumu, Kisumu, Kenya. [Angov, Evelina] US Mil Malaria Vaccine Program, Div Malaria Vaccine Dev, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Ong'echa, John M.; Perkins, Douglas J.] Univ New Mexico, Ctr Global Hlth, Albuquerque, NM 87131 USA. [Ong'echa, John M.; Perkins, Douglas J.] Univ New Mexico KFMRI, Ctr Global Hlth Res, Lab Viral & Parasit Dis, Kisumu, Kenya. [Zhou, Guofa; Yan, Guiyun] Univ Calif Irvine, Coll Hlth Sci, Program Publ Hlth, Irvine, CA 92697 USA. RP Badu, K (reprint author), Kenya Govt Med Res Ctr, Ctr Global Hlth Res, Kisumu, Kenya. EM kingsleybadu@yahoo.com FU National Institute of Health [D43 TW001505, R01 A1050243] FX Provided by grants from the National Institute of Health (D43 TW001505 and R01 A1050243) NR 52 TC 15 Z9 15 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD MAR 1 PY 2012 VL 12 AR 50 DI 10.1186/1471-2334-12-50 PG 9 WC Infectious Diseases SC Infectious Diseases GA 914FH UT WOS:000301934200001 PM 22380785 ER PT J AU West, BJ West, D AF West, Bruce J. West, Damien TI FRACTIONAL DYNAMICS OF ALLOMETRY SO FRACTIONAL CALCULUS AND APPLIED ANALYSIS LA English DT Article DE allometry; allometry coefficient; allometry exponent; fractal statistics; co-variation; Pareto distribution; entropy; self-similarity; scaling; fractal scaling; universality; fractional dynamics; interspecies allometry relation; intraspecies allometry relation; fluctuations; probability density; data; linear regression; phenomenological distributions; histogram; inverse power law; fractional probability; fractional diffusion equation; Levy distribution; Fokker-Planck equation; renormalization group relation; entropy balance; networks ID COMPLEX NETWORKS; LOGARITHMIC TRANSFORMATION; SCALING LAWS; RANDOM-WALKS; POWER; METABOLISM; UNIVERSAL; BIOLOGY; ORIGIN; INFORMATION AB Allometry relations (ARs) in physiology are nearly two hundred years old. In general if X-ij is a measure of the size of the i(th) member of a complex host network from species j and Y-ij is a property of a complex subnetwork embedded within the host network an intraspecies AR exists between the two when Y-ij = aX(ij)(b). We emphasize that the reductionist models of AR interpret X-ij and Y-ij as dynamic variables, albeit the ARs themselves are explicitly time independent. On the other hand, the phenomenological models of AR are based on the statistical analysis of data and interpret < X-i > and < Y-i > as averages over an ensemble of individuals to yields the interspecies AR < Y-i > = a < X-i >(b). Modern explanations of AR begin with the application of fractal geometry and fractal statistics to scaling phenomena. The detailed application of fractal geometry to the explanation of intraspecies ARs is a little over a decade old and although well received it has not been universally accepted. An alternate perspective is given by the interspecies AR based on linear regression analysis of fluctuating data sets. We emphasize that the intraspecies and interspecies ARs are not the same and show that the interspecies AR can only be derived from the intraspecies one for a narrow distribution of fluctuations. This condition is not satisfied by metabolic data as is shown separately for aviary and mammal data sets. The empirical distribution of metabolic allometry coefficients is shown herein to be Pareto in form. A number of reductionist arguments conclude that the allometry exponent is universal, however herein we derive a deterministic relation between the allometry exponent and the allometry coefficient using the fractional calculus. The co-variation relation violates the universality assumption. We conclude that the interspecies physiologic AR is entailed by the scaling behavior of the probability density, which is derived using the fractional probability calculus. C1 [West, Bruce J.] USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. [West, Damien] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. RP West, BJ (reprint author), USA, Res Off, Informat Sci Directorate, Durham, NC 27709 USA. EM bruce.j.west.civ@mail.mil RI West, Damien/F-8616-2012 OI West, Damien/0000-0002-4970-3968 NR 69 TC 8 Z9 8 U1 1 U2 14 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 1311-0454 EI 1314-2224 J9 FRACT CALC APPL ANAL JI Fract. Calc. Appl. Anal. PD MAR PY 2012 VL 15 IS 1 BP 70 EP 96 DI 10.2478/s13540-012-0006-3 PG 27 WC Mathematics, Applied; Mathematics, Interdisciplinary Applications; Mathematics SC Mathematics GA 913GO UT WOS:000301865000005 ER PT J AU Ford, BQ Tamir, M Gagnon, SA Taylor, HA Brunye, TT AF Ford, Brett Q. Tamir, Maya Gagnon, Stephanie A. Taylor, Holly A. Brunye, Tad T. TI The Angry Spotlight: Trait Anger and Selective Visual Attention to Rewards SO EUROPEAN JOURNAL OF PERSONALITY LA English DT Article DE anger; anxiety; selective attention; motivation; emotion ID EMOTIONAL INFORMATION; PROCESSING BIAS; ANXIETY-STATES; POSITIVE MOOD; THREAT CUES; STIMULI; AGGRESSION; WORDS; HOSTILITY; VARIABLES AB This investigation examined links between trait anger and selective attention to threats and rewards. Existing research has focused mainly on trait anxiety and is equally consistent with several competing theoretical accounts of trait emotion and visual attention. Both valence-based and motivation-based accounts predict that trait anxiety would be associated with biased attention toward threats. In contrast, a valence-based account predicts that trait anger would be associated with biased attention toward threats, whereas a motivation-based account predicts that it would be associated with biased attention toward rewards. To test these predictions, we measured trait anxiety, trait anger and selective attention to threats and rewards. Consistent with a motivation-based account, we found that trait anger was associated with selective attention toward rewarding but not threatening information, whereas trait anxiety was associated with selective attention toward threatening but not rewarding information. Copyright (C) 2012 John Wiley & Sons, Ltd. C1 [Ford, Brett Q.] Univ Denver, Dept Psychol, Denver, CO 80208 USA. [Tamir, Maya] Hebrew Univ Jerusalem, Jerusalem, Israel. [Tamir, Maya] Boston Coll, Boston, MA USA. [Gagnon, Stephanie A.; Brunye, Tad T.] USA, NSRDEC, Natick, MA 01760 USA. [Gagnon, Stephanie A.; Taylor, Holly A.; Brunye, Tad T.] Tufts Univ, Medford, MA 02155 USA. RP Ford, BQ (reprint author), Univ Denver, Dept Psychol, Frontier Hall,2155 S Race St, Denver, CO 80208 USA. EM Brett.Q.Ford@du.edu NR 48 TC 5 Z9 5 U1 2 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0890-2070 J9 EUR J PERSONALITY JI Eur. J. Personal. PD MAR-APR PY 2012 VL 26 IS 2 SI SI BP 90 EP 98 DI 10.1002/per.1840 PG 9 WC Psychology, Social SC Psychology GA 911HF UT WOS:000301707200002 ER PT J AU Meredith, CS Khan, AS AF Meredith, Christopher S. Khan, Akhtar S. TI Texture evolution and anisotropy in the thermo-mechanical response of UFG Ti processed via equal channel angular pressing SO INTERNATIONAL JOURNAL OF PLASTICITY LA English DT Article DE Strengthening mechanisms; Anisotropic material; Metallic material; Kolsky bar ID PURITY ALPHA-TITANIUM; STRAIN-RATES; WIDE-RANGE; NANOSTRUCTURED TITANIUM; DEFORMATION STRUCTURES; MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; SIMPLE SHEAR; PURE TI; TEMPERATURE AB The texture evolution and thermo-mechanical response of grade 1 titanium after equal channel angular pressing (ECAP) at different strain rates and temperatures were measured. As-received Ti was processed via ECAP at 275 degrees C for up to four passes using route B-C. The uniform microstructure from the as-received condition, goes from long, coarse bands with some grains relatively undeformed after a single pass to mostly uniform fine and ultrafine grains after four passes. The texture of the as-received Ti was of a typical cold-rolled plate. The basal plane normal direction stayed perpendicular to, and rotated about, the longitudinal direction of the billet during all numbers of passes. The mechanical response of UFG Ti, subjected to four passes, was determined at -196, 22 and 375 degrees C, and at strain rates from 10(-4) to 2000 s(-1) in the different loading directions. It was found that the yield strength and flow stress were different in all three loading directions, at all strain rates and testing temperatures. Macroscopic shear band failure was observed in the samples subjected to dynamic loading, and the onset was dependent on the loading direction and testing temperature. Finally, the anisotropy shows up in the yield strength between tension and compression loading, where it is greater in tension. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Meredith, Christopher S.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Meredith, Christopher S.; Khan, Akhtar S.] Univ Maryland, Dept Mech Engn, Baltimore, MD 21250 USA. RP Meredith, CS (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM christopher.s.meredith3.ctr@mail.mil OI Meredith, Christopher/0000-0003-1368-8003 FU GAANN from Department of Mechanical Engineering at UMBC FX This work was supported by the GAANN fellowship from the Department of Mechanical Engineering at UMBC. Brady Butler at the Army Research Lab, in Aberdeen, MD performed the XRD experiments. The salt used for heating the billets was obtained free of charge from Hubbard-Hall Inc. NR 37 TC 31 Z9 31 U1 1 U2 28 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0749-6419 J9 INT J PLASTICITY JI Int. J. Plast. PD MAR-APR PY 2012 VL 30-31 BP 202 EP 217 DI 10.1016/j.ijplas.2011.10.006 PG 16 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 910GY UT WOS:000301626400010 ER PT J AU Crites, JW Phelps, QE McCain, KNS Herzog, DP Hrabik, RA AF Crites, Jason W. Phelps, Quinton E. McCain, Kathryn N. S. Herzog, David P. Hrabik, Robert A. TI An investigation of fish community and water quality compositions in an isolated side channel of the upper Mississippi River SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article DE Buffalo Chute; fish monitoring; Mississippi River; restoration; side channel; water quality monitoring ID HABITAT USE; PADDLEFISH AB Varying degrees of connectivity between side channels and the main river channel are vital for sustainable ecological processes and functions for both aquatic and terrestrial communities. Within the Mississippi River, restoring side channel functional diversity is a top priority for many natural resource agencies. Buffalo Chute, located at river kilometer 41, is one of the several side channels, island complexes that becomes isolated from the main channel during low river stages leading to thermal and chemical stratifications and anoxic conditions. The purpose of this study was to better understand the impacts of side-channel isolation in the middle Mississippi River (MMR) by measuring fish community and water quality characteristics within an isolated waterbody. Therefore, we selected Buffalo Chute a representative side channel of the MMR to document water quality and fish community characteristics. Water quality measurements were summarized for the 2-year study. Thermal and chemical stratifications coupled with high water temperatures and anoxic conditions were observed in both years during summer. Oxygen reduction potential was lower in summer than winter, which could be attributed to excessive growth of microorganisms and increased biological oxygen demand. Specific conductivity, total phosphorus, total nitrogen, and chlorophyll a were higher in summer compared to winter. Differences in water quality characteristics may have resulted in lower mean fish species richness, diversity, and evenness observed during the following winter. We surveyed 45 sites over 2 years using multiple gears to assess fish assemblage characteristics. The data collected in Buffalo Chute provide some insight into how isolated side channels function during low flow periods. C1 [Crites, Jason W.; Phelps, Quinton E.; Herzog, David P.; Hrabik, Robert A.] Missouri Dept Conservat, Open Rivers & Wetlands Field Stn, Jackson, MO 63755 USA. [McCain, Kathryn N. S.] USA, Corps Engineers, St Louis, MO 63103 USA. RP Crites, JW (reprint author), Missouri Dept Conservat, Open Rivers & Wetlands Field Stn, 3815 E Jackson Blvd, Jackson, MO 63755 USA. EM Jason.Crites@mdc.mo.gov FU US Army Corps of Engineers FX We thank the US Army Corps of Engineers for funding this project through the Navigation and Environmental Sustainability Program (NESP). We thank B. Johnson and K. Slattery of the St. Louis Corps for their assistance and corporation throughout the 2 years of this study. We also recognize D. Ostendorf, J. Ridings, A. Kelley, Z. Fratto, J. McMullen, A. Givens, L. Solomon, B. Swallows, C. Gump, A. Lamb, D. Huff, B. Landwer, and M. Elder for assisting with data collection. NR 33 TC 1 Z9 1 U1 1 U2 10 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD MAR PY 2012 VL 27 IS 1 BP 19 EP 29 DI 10.1080/02705060.2011.599988 PG 11 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 911YC UT WOS:000301759600002 ER EF