FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Stinner, DJ Beltran, MJ Masini, BD Wenke, JC Hsu, JR AF Stinner, Daniel J. Beltran, Michael J. Masini, Brendan D. Wenke, Joseph C. Hsu, Joseph R. TI Bacteria on external fixators: Which prep is best? SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY LA English DT Article DE External-fixation; infection; surgical prep; surgical-site infection; invasive distraction ID POVIDONE-IODINE; CHLORHEXIDINE; MANAGEMENT; INFECTION; FRACTURES; SURGERY; MODEL; ANTISEPSIS; PROTOCOL; SKIN AB BACKGROUND: There are no established guidelines for the surgical prep of an external fixator in the operative field. This study investigates the effectiveness of different prep solutions and methods of application. METHODS: Forty external fixator constructs, consisting of a rod, pin, and pin to rod coupling device, were immersed in a broth of Staphylococcus aureus (lux) for 12 hours. Constructs were then randomized into four treatment groups: chlorhexidine-gluconate (CHG) (4%) scrub, CHG (4%) spray, povidone-iodine (PI) (10%) scrub, and PI (10%) spray. Each construct was imaged with a specialized photon capturing camera system yielding the quantitative and spatial distribution of bacteria both before and after the prep. Each pin to bar clamp was loosened and moved 2 cm down the construct, simulating an external fixator adjustment, and reimaged. Spatial distribution of bacteria and total bacteria counts were compared. RESULTS: There was a similar reduction in bacteria after surgical prep when comparing all four groups independently (p = 0.19), method of application (spray vs. scrub, p = 0.27), and different solutions (CHG vs. PI, p = 0.41). Although bacteria were evident in newly exposed areas after external fixator adjustment, most notably within the loosened pin to bar clamp, it did not result in an increase in bacteria counts (all four groups, p = 0.11; spray vs. scrub, p = 0.18; CHG vs. PI, p = 0.99). CONCLUSIONS: Although there was no increase in bacteria counts after the simulated external fixator adjustment, it did expose additional bacteria previously unseen. Although there was no difference in surgical prep solution or method of application, consideration must be given to performing an additional surgical prep of the newly exposed surface after loosening of each individual external fixator component as this may further minimize potential bacteria exposure. (J Trauma. 2012; 72: 760-764. Copyright (C) 2012 by Lippincott Williams & Wilkins) C1 [Stinner, Daniel J.; Wenke, Joseph C.] USA, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. [Beltran, Michael J.; Masini, Brendan D.; Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, San Antonio, TX USA. RP Stinner, DJ (reprint author), USA, Inst Surg Res, Dept Regenerat Med, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM daniel.stinner@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 17 TC 2 Z9 2 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 2163-0755 J9 J TRAUMA ACUTE CARE JI J. Trauma Acute Care Surg. PD MAR PY 2012 VL 72 IS 3 BP 760 EP 764 DI 10.1097/TA.0b013e31823c97f5 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 906TR UT WOS:000301371100048 PM 22491567 ER PT J AU Ames, M Zemba, S Green, L Botelho, MJ Gossman, D Linkov, I Palma-Oliveira, J AF Ames, Michael Zemba, Stephen Green, Laura Botelho, Maria Joao Gossman, David Linkov, Igor Palma-Oliveira, Jose TI Polychlorinated dibenzo(p)dioxin and furan (PCDD/F) congener profiles in cement kiln emissions and impacts SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Cement kilns; Hazardous waste incineration; PCDD/F congeners; Dioxins; Emission profiles ID DIBENZO-P-DIOXINS; METALS; FUEL; AIR AB Cement kilns are known to emit polychlorinated dibenzo(p)dioxins and furans (PCDD/Fs: "dioxins"), but estimates of the amounts and patterns of these emissions vary widely. These variations may stem from a combination of factors, including the design and operating conditions of the kiln, and the fuels and raw materials fed into the kiln. The goal of this study was to examine the patterns of dioxin emissions in a large set of stack-tests at two Portland cement kilns in Portugal that use a variety of fuels. A total of 152 stack-tests provided data on PCDD/F congener concentrations during which the kilns combusted a varied mix of fuels, including petroleum coke, coal, various "special" supplemental fuels, and refinery distillation ends, which are classified as hazardous wastes. The use of coal to fuel the kilns was found to generate significantly different emission-profiles relative to the use of petroleum coke, but the addition of hazardous wastes as a supplemental fuel did not significantly alter profiles. All of the kiln emission profiles were found to differ markedly from profiles in ambient air. However, the small absolute dioxin emission rates from the kilns suggested that kiln impacts would not be detectable via ambient air monitoring, even in rural settings. (C) 2012 Elsevier B.V. All rights reserved. C1 [Palma-Oliveira, Jose] Univ Lisbon, Fac Psicol, P-1649013 Lisbon, Portugal. [Ames, Michael; Zemba, Stephen; Green, Laura] Cambridge Environm Inc, Cambridge, MA 02141 USA. [Botelho, Maria Joao] Secil Co Geral Cal & Cimento, Lisbon, Portugal. [Gossman, David] Gossman Consulting Inc, Maquoketa, IA 52060 USA. [Linkov, Igor] USA, Engn Res & Dev Ctr, Concord, MA 02446 USA. RP Palma-Oliveira, J (reprint author), Univ Lisbon, Fac Psicol, Alameda Univ, P-1649013 Lisbon, Portugal. EM Ames@CambridgeEnvironmental.com; Zemba@CambridgeEnvironmental.com; Green@CambridgeEnvironmental.com; maria.joao.botelho@secil.pt; dgossman@gcisolutions.com; ilinkov@yahoo.com; jpalma-oliveira@fp.ul.pt OI Palma-Oliveira, Jose/0000-0001-9799-3464 FU Secil Companhia Geral de Cal e Cimento S.A. FX This work was sponsored in part by Secil Companhia Geral de Cal e Cimento S.A. Stack test sampling and analyses were performed by Eurofins/Ergo. Atmospheric dispersion modeling of PCDD/F emissions from the Secil kilns was performed by UVW and Professor Nelson Barros of University of Fernando Pessoa, Porto, Portugal. NR 22 TC 17 Z9 19 U1 1 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD MAR 1 PY 2012 VL 419 BP 37 EP 43 DI 10.1016/j.scitotenv.2011.12.062 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 910KC UT WOS:000301634600005 PM 22285082 ER PT J AU Harms, NE Grodowitz, MJ AF Harms, Nathan E. Grodowitz, Michael J. TI HERBIVOROUS INSECTS ASSOCIATED WITH LUDWIGIA PEPLOIDES (ONAGRACEAE) IN THE SOUTHERN UNITED STATES SO SOUTHWESTERN NATURALIST LA English DT Article ID LYSATHIA-LUDOVICIANA; BIOLOGICAL-CONTROL; NYMPHULINAE; LEPIDOPTERA; CAROLINA; BEETLE AB The wetland plant Ludwigia peploides (floating primrose-willow) often is problematic in the southern USA, as well as elsewhere in its introduced range. Surveys to identify potential herbivorous insects to use as biological controls have focused on South America, but implementing a management program with foreign insects in the USA is difficult and can take years of testing in quarantine. During 2006-2008, populations of floating primrose-willow were surveyed in the southern USA to determine presence and extent of native herbivorous insects. At least nine species were identified, represented mainly by weevils (Curculionidae) and leaf beetles (Chrysomelidae). Of these, two were undescribed species of weevils (Auleutes), and six species, including Tyloderma sphaerocarpae and Chaetocnema, have never been associated with floating primrose-willow. C1 [Harms, Nathan E.] Univ N Texas Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Grodowitz, Michael J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Harms, NE (reprint author), Univ N Texas Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM Nathan.E.Harms@usace.army.mil NR 28 TC 3 Z9 3 U1 1 U2 13 PU SOUTHWESTERN ASSOC NATURALISTS PI SAN MARCOS PA SOUTHWEST TEXAS STATE UNIV, DEPT BIOLOGY, 601 UNIVERSITY DR, SAN MARCOS, TX 78666 USA SN 0038-4909 J9 SOUTHWEST NAT JI Southw. Natural. PD MAR PY 2012 VL 57 IS 1 BP 123 EP 127 PG 5 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 911CJ UT WOS:000301694600021 ER PT J AU Farthing, MW Fowler, KR Fu, X Davis, A Miller, CT AF Farthing, M. W. Fowler, K. R. Fu, X. Davis, A. Miller, C. T. TI Effects of model resolution on optimal design of subsurface flow and transport problems SO ADVANCES IN WATER RESOURCES LA English DT Article DE Well model; Genetic algorithm; Model error; Community problems ID DERIVATIVE-FREE OPTIMIZATION; HYDRAULIC CONTROL; ALGORITHMS; SIMULATION; SYSTEMS; CONSTRAINTS; MANAGEMENT; SEARCH; IMPACT; SOLVER AB Mathematical modeling of water resources problems is regularly undertaken to aid the management or design of a system. These optimal design problems can require a large number of model simulations with different sets of design variables. In an effort to reduce the computational expense of such design problems, various sources of error are typically introduced into the numerical model simulations, often without explicit consideration of subsequent effects on solution quality. We investigate several sources of such errors, including model formulation, grid resolution, and solver error for a set of community test problems, which have received attention in the literature as a vehicle to evaluate and evolve optimization methods. Results show that common shortcuts used to reduce computational effort can lead to inaccurate solutions that differ quantitatively and qualitatively from optimal solutions found using highly resolved methods. In addition to highlighting what we believe is a common issue, we present improved solutions to the problems considered, identify alternative model and optimization formulations that give equivalent accuracy with reduced computational effort, and provide guidance for improving generally the reliability of optimal design solutions to water resources problems. Published by Elsevier Ltd. C1 [Farthing, M. W.] USA, Engineer Res & Dev Stn, ATTN CEERD HF HG, Vicksburg, MS 39180 USA. [Fowler, K. R.; Fu, X.; Davis, A.] Clarkson Univ, Dept Math & Comp Sci, Potsdam, NY 13699 USA. [Miller, C. T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. RP Farthing, MW (reprint author), USA, Engineer Res & Dev Stn, ATTN CEERD HF HG, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM matthew.w.farthing@usace.army.mil; kfowler@clarkson.edu; fux@clarkson.edu; kfowler@clarkson.edu; casey_miller@unc.edu RI Miller, Cass T./I-6613-2012 OI Miller, Cass T./0000-0001-6082-9273 FU Clarkson Honors Program FX The work at Clarkson University was partial supported by Clarkson Honors Program. The Chief of Engineers has granted permission to publish this manuscript. NR 55 TC 3 Z9 3 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0309-1708 EI 1872-9657 J9 ADV WATER RESOUR JI Adv. Water Resour. PD MAR PY 2012 VL 38 BP 27 EP 37 DI 10.1016/j.advwatres.2011.12.002 PG 11 WC Water Resources SC Water Resources GA 904QQ UT WOS:000301213400003 ER PT J AU Wang, JY AF Wang, James Y. TI Life as a Combat Gastroenterologist SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter C1 William Beaumont Army Med Ctr, USA, El Paso, TX 79920 USA. RP Wang, JY (reprint author), William Beaumont Army Med Ctr, USA, 3-4 CAV,3rd Brigade,25th ID, El Paso, TX 79920 USA. EM s3jwang@gmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD MAR PY 2012 VL 107 IS 3 BP 489 EP 490 DI 10.1038/ajg.2011.453 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 908NH UT WOS:000301496600030 PM 22388035 ER PT J AU Heiner, JD Trabulsy, ME AF Heiner, Jason D. Trabulsy, Mario E. TI Words for the Living Reply SO ANNALS OF EMERGENCY MEDICINE LA English DT Letter C1 [Heiner, Jason D.] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Trabulsy, Mario E.] Univ Vermont, Coll Med, Div Emergency Med, Burlington, VT USA. RP Heiner, JD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD MAR PY 2012 VL 59 IS 3 BP 236 EP 236 DI 10.1016/j.annemergmed.2011.10.001 PG 1 WC Emergency Medicine SC Emergency Medicine GA 905MM UT WOS:000301276300022 ER PT J AU De Lucia, FC Gottfried, JL AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. TI Classification of explosive residues on organic substrates using laser induced breakdown spectroscopy SO APPLIED OPTICS LA English DT Article ID RAMAN-SPECTROSCOPY; DISCRIMINATION; IDENTIFICATION; SPECTROMETER; CHEMOMETRICS; MINERALS; SPECTRA; SENSOR; LIBS; MARS AB Standoff laser induced breakdown spectroscopy (LIBS) has previously been used to classify trace residues as either hazardous (explosives, biological, etc.) or benign. Correct classification can become more difficult depending on the surface/substrate underneath the residue due to variations in the laser-material interaction. In addition, classification can become problematic if the substrate material has a similar elemental composition to the residue. We have evaluated coupling multivariate analysis with standoff LIBS to determine the effectiveness of classifying thin explosive residue layers on painted surfaces. Good classification results were obtained despite the fact that the painted surface contributes to the LIBS emission signal. (C) 2012 Optical Society of America C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.] USA, Res Lab, RDRL WML A, Aberdeen Proving Ground, MD 21005 USA. RP De Lucia, FC (reprint author), USA, Res Lab, RDRL WML A, Aberdeen Proving Ground, MD 21005 USA. EM frank.c.delucia.civ@mail.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012 NR 26 TC 24 Z9 24 U1 3 U2 25 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 2012 VL 51 IS 7 BP B83 EP B92 DI 10.1364/AO.51.000B83 PG 10 WC Optics SC Optics GA 904JD UT WOS:000301190000013 PM 22410930 ER PT J AU Gottfried, JL AF Gottfried, Jennifer L. TI Laser-induced plasma chemistry of the explosive RDX with various metallic nanoparticles SO APPLIED OPTICS LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; ALUMINUM; ABLATION; COMBUSTION AB The feasibility of exploiting plasma chemistry to study the chemical reactions between metallic nanoparticles and molecular explosives such as cyclotrimethylenetrinitramine (RDX) has been demonstrated. This method, based on laser-induced breakdown spectroscopy, involves the production of nanoparticles in a laser-induced plasma and the simultaneous observation of time-resolved atomic and molecular emission characteristic of the species involved in the intermediate chemical reactions of the nanoenergetic material in the plasma. Using this method, it has been confirmed that the presence of aluminum promotes the ejection process of carbon from the intermediate products of RDX. The time evolution of species formation, the effects of laser pulse energy, and the effects of trace metal content on the chemical reactions were also studied. C1 USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Gottfried, JL (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM jennifer.gottfried@us.army.mil RI Gottfried, Jennifer/G-6333-2010 NR 31 TC 12 Z9 12 U1 2 U2 21 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 2012 VL 51 IS 7 BP B13 EP B21 DI 10.1364/AO.51.000B13 PG 9 WC Optics SC Optics GA 904JD UT WOS:000301190000005 PM 22410910 ER PT J AU Singh, JP Almirall, J Sabsabi, M Miziolek, AW AF Singh, Jagdish P. Almirall, Jose Sabsabi, Mohamad Miziolek, Andrzej W. TI North American Symposium on Laser Induced Breakdown Spectroscopy (NASLIBS): introduction to feature issue SO APPLIED OPTICS LA English DT Article AB This feature issue highlights the topics of the 2011 North American Symposium on Laser Induced Breakdown Spectroscopy (NASLIBS). These include LIBS application to Security and Forensic, Biomedical and Environmental, Liquid Analysis and Fundamentals of LIBS, Instrumentation/Commercialization, Fusion with LIBS, and New Frontiers. (C) 2012 Optical Society of America C1 [Singh, Jagdish P.] Mississippi State Univ, ICET, Starkville, MS 39759 USA. [Almirall, Jose] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA. [Almirall, Jose] Florida Int Univ, Int Forens Inst, Miami, FL 33199 USA. [Sabsabi, Mohamad] Natl Res Council Canada, Inst Ind Mat, Boucherville, PQ J4B 6Y4, Canada. [Miziolek, Andrzej W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Singh, JP (reprint author), Mississippi State Univ, ICET, 205 Res Blvd, Starkville, MS 39759 USA. EM singh@icet.msstate.edu RI Almirall, Jose/D-1280-2010 OI Almirall, Jose/0000-0002-5257-7499 NR 0 TC 0 Z9 0 U1 3 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAR 1 PY 2012 VL 51 IS 7 BP LIBS1 EP LIBS2 DI 10.1364/AO.51.0LIBS1 PG 2 WC Optics SC Optics GA 904JD UT WOS:000301190000002 PM 22410934 ER PT J AU Wagler, VD Huitron, S King, CS AF Wagler, Vanya D. Huitron, Sonny King, Christopher S. TI A 26-year-old woman with a lump in her chest SO CLEVELAND CLINIC JOURNAL OF MEDICINE LA English DT Editorial Material ID TUBERCULOSIS C1 [Wagler, Vanya D.; Huitron, Sonny] William Beaumont Army Med Ctr, Dept Internal Med, El Paso, TX 79920 USA. [Wagler, Vanya D.; Huitron, Sonny; King, Christopher S.] USA, Med Corps, El Paso, TX USA. RP Wagler, VD (reprint author), William Beaumont Army Med Ctr, Dept Internal Med, 5005 N Piedras St, El Paso, TX 79920 USA. EM vwagler@gmail.com NR 7 TC 1 Z9 1 U1 0 U2 1 PU CLEVELAND CLINIC PI CLEVELAND PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA SN 0891-1150 J9 CLEV CLIN J MED JI Clevel. Clin. J. Med. PD MAR PY 2012 VL 79 IS 3 BP 177 EP 178 DI 10.3949/ccjm.79a.11070 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 907FK UT WOS:000301403000008 PM 22383551 ER PT J AU Bales, J Bales, K Baugh, L Tokish, J AF Bales, James Bales, Karrn Baugh, Laura Tokish, John TI Evaluation for Ulnar Neuropathy at the Elbow in Ironman Triathletes: Physical Examination and Electrodiagnostic Evidence SO CLINICAL JOURNAL OF SPORT MEDICINE LA English DT Article DE triathlon; Ironman; ulnar nerve; aerobars ID NERVE; COMPRESSION AB Objective: Evaluation of the elbow in Ironman triathletes for ulnar compression neuropathy caused by aerobar use. Design: Descriptive laboratory study. Setting: Ironman California 70.3, Ironman Arizona, Ironman New Orleans 70.3, San Antonio, Texas. Participants: Study 1: (n = 712) Ironman California 70.3/Ironman Arizona participants. Study 2: (n = 54) Ironman New Orleans 70.3 finishers. Study 3: (n = 11) participants training for an Ironman triathlon. Interventions: Pilot questionnaire (study 1). Pilot questionnaire and prerace and postrace physical examination (study 2). Pilot questionnaire and preride and postride (and postseason) physical examination, and electrodiagnostic testing (study 3). Main Outcome Measures: Participants with symptoms, physical examination findings, and electrodiagnostic findings (amplitude or conduction velocity decrease) (P < 0.05). Results: In study 1, 20.8% reported a history of ulnar symptoms. In study 2, 35.2% reported a history of ulnar symptoms. Preevent physical examination testing of the elbow showed 39.5% with positive Tinel sign and 41.5% with positive flexion/compression test. Postevent testing showed 70.4% with positive Tinel sign and 75.9% with positive flexion/compression test. In study 3, 46% reported ulnar symptoms. Preride physical examination testing showed 4.5% with positive Tinel sign and 9% with positive flexion/compression test. Postride testing showed 95.5% with positive Tinel sign and 91% with positive flexion/compression test. Postseason testing showed 64% with positive Tinel sign and 82% with positive flexion/compression test. Electrodiagnostic testing comparing preride and postride showed that ulnar nerve latency increased in 82%, amplitude decreased in 50%, and conduction velocity slowed in 64%. Electrodiagnostic testing comparing preseason and postseason showed that ulnar nerve latency increased in 73%, amplitude decreased in 64%, and conduction velocity slowed in 82%. Conclusions: The findings support the hypothesis of an ulnar compression neuropathy at the elbow occurring at high rates in aerobar using Ironman triathletes. Level of Significance: Prospective comparative study, 2. C1 [Bales, James; Bales, Karrn; Baugh, Laura; Tokish, John] Wilford Hall Med Ctr Lackland AFB, Dept Orthopaed Surg, San Antonio, TX USA. [Bales, Karrn] CHRISTUS Santa Rosa, San Antonio, TX USA. [Bales, James] USAF Acad, Colorado Springs, CO 80840 USA. [Baugh, Laura] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA. [Tokish, John] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA. RP Bales, J (reprint author), 18270 Bent Oak Lane, Monument, CO 80132 USA. EM jrtbales@gmail.com NR 6 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1050-642X J9 CLIN J SPORT MED JI Clin. J. Sport Med. PD MAR PY 2012 VL 22 IS 2 BP 126 EP 131 DI 10.1097/JSM.0b013e3182427003 PG 6 WC Orthopedics; Physiology; Sport Sciences SC Orthopedics; Physiology; Sport Sciences GA 908RG UT WOS:000301507200010 PM 22366630 ER PT J AU Luo, YT Guo, JC Wang, CS Chu, D AF Luo, Yanting Guo, Juchen Wang, Chunsheng Chu, Deryn TI Fuel cell durability enhancement by crosslinking alkaline anion exchange membrane electrolyte SO ELECTROCHEMISTRY COMMUNICATIONS LA English DT Article DE Energy conversion; Fuel cells; Polymer electrolytes; s-IPN system; Crosslinking ID SEMIINTERPENETRATING POLYMER NETWORK; CHITOSAN; METHACRYLATE; POLYSTYRENE AB Our previously investigated quatemized poly (methyl methacrylate-co-butyl acrylate-co-vinylbenzyl chloride) (QPMBV) AAEM (alkaline anion exchange membrane) showed exceptional fuel cell performance, yet the poor durability is still remained to solve. The focus of this research is to enhance the durability of QPMBV AAEM through monomer reselection and crosslinking, which increases T-g by 20 degrees C and decreases water uptake by 75%. The resulted AAEM can continuously work for 420 and 146 hrs in fuel cell without significant performance decline at 50 degrees C and 70 degrees C, respectively. (C) 2012 Elsevier B.V. All rights reserved. C1 [Luo, Yanting; Guo, Juchen; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Chu, Deryn] USA, Sensors & Electron Device Directorate, Res Lab, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Office of Naval Research [N000140810717]; Army Research Lab [W911NF0920007]; Army Research Office [W911NF0910028] FX The authors gratefully acknowledge the supports of this project by: 1. Office of Naval Research: N000140810717; 2. Army Research Lab: W911NF0920007; 3. Army Research Office: W911NF0910028. NR 20 TC 30 Z9 31 U1 4 U2 47 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1388-2481 J9 ELECTROCHEM COMMUN JI Electrochem. Commun. PD MAR PY 2012 VL 16 IS 1 BP 65 EP 68 DI 10.1016/j.elecom.2012.01.005 PG 4 WC Electrochemistry SC Electrochemistry GA 910DK UT WOS:000301617200017 ER PT J AU Dodd, LE Lacki, MJ Britzke, ER Buehler, DA Keyser, PD Larkin, JL Rodewald, AD Wigley, TB Wood, PB Rieske, LK AF Dodd, Luke E. Lacki, Michael J. Britzke, Eric R. Buehler, David A. Keyser, Patrick D. Larkin, Jeffrey L. Rodewald, Amanda D. Wigley, T. Bently Wood, Petra B. Rieske, Lynne K. TI Forest structure affects trophic linkages: How silvicultural disturbance impacts bats and their insect prey SO FOREST ECOLOGY AND MANAGEMENT LA English DT Article DE Arthropod diversity; Foraging ecology; Logging; Predator-prey interactions; Trophic interactions ID EASTERN DECIDUOUS FORESTS; BOREAL FOREST; SPECIES-DIVERSITY; FORAGING HABITAT; NORTH-AMERICA; EARED BAT; CONSERVATION; MANAGEMENT; COMMUNITY; BIODIVERSITY AB Vertebrate insectivores such as bats are a pervasive top-down force on prey populations in forest ecosystems. Conservation focusing on forest-dwelling bats requires understanding of community-level interactions between these predators and their insect prey. Our study assessed bat activity and insect occurrence (abundance and diversity) across a gradient of forest disturbance and structure (silvicultural treatments) in the Central Appalachian region of North America. We conducted acoustic surveys of bat echolocation concurrent with insect surveys using blacklight and malaise traps over 2 years. Predator activity, prey occurrence and prey biomass varied seasonally and across the region. The number of bat echolocation pulses was positively related with forest disturbance, whereas prey demonstrated varied trends. Lepidopteran abundance was negatively related with disturbance, while dipteran abundance and diversity was positively related with disturbance. Coleoptera were unaffected. Neither bat nor insect response variables differed between plot interiors and edges. Correlations between bat activity and vegetative structure reflected differences in foraging behavior among ensembles. Activity of myotine bats was correlated with variables describing sub-canopy vegetation, whereas activity of lasiurine bats was more closely correlated with canopy-level vegetation. Lepidopteran abundance was correlated with variables describing canopy and sub-canopy vegetation, whereas coleopteran and dipteran occurrence were more closely correlated with canopy-level vegetative structure. Our study demonstrates regional variation in bat activity and prey occurrence across a forested disturbance gradient. Land management and conservation efforts should consider the importance of vegetation structure and plant species richness to sustain forest-dwelling bats and their insect prey. (C) 2011 Elsevier B.V. All rights reserved. C1 [Dodd, Luke E.; Rieske, Lynne K.] Univ Kentucky, Dept Entomol, Lexington, KY 40546 USA. [Lacki, Michael J.] Univ Kentucky, Dept Forestry, Lexington, KY 40546 USA. [Britzke, Eric R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Buehler, David A.; Keyser, Patrick D.] Univ Tennessee, Dept Forestry Wildlife & Fisheries, Knoxville, TN USA. [Larkin, Jeffrey L.] Indiana Univ Penn, Dept Biol, Indiana, PA 15705 USA. [Rodewald, Amanda D.] Ohio State Univ, Sch Environm & Nat Resources, Columbus, OH 43210 USA. [Wigley, T. Bently] Clemson Univ, Natl Council Air & Stream Improvement Inc, Clemson, SC USA. [Wood, Petra B.] W Virginia Univ, US Geol Survey, W Virginia Cooperat Fish & Wildlife Res Unit, Morgantown, WV 26506 USA. RP Dodd, LE (reprint author), Univ Kentucky, Dept Entomol, Lexington, KY 40546 USA. EM luke.dodd@uky.edu RI Rodewald, Amanda/D-2038-2012; Rodewald, Amanda/I-6308-2016 OI Rodewald, Amanda/0000-0002-6719-6306 FU McIntire-Stennis; National Council for Air and Stream Improvement, Inc.; West Virginia Division of Natural Resources; Plum Creek Timber Company; Mead Westvaco Corporation; US Fish and Wildlife Service FX The authors would like to thank J. Adams, M. Antonik, A. Barlows, T. Beachy, T. Boves, E. Carlisle, D. Cox, T. Culbertson, D. Chalkley, A. Evans, G. George, S. Gravitt, P. Hartman, J. Mizel, F. Newell, J. Rasmussen, J. Sheehan, R. Smith, M. Ware, and J. Wong for technical assistance. This research was made possible through McIntire-Stennis funding and Grant monies from the National Council for Air and Stream Improvement, Inc., the West Virginia Division of Natural Resources, Plum Creek Timber Company, Mead Westvaco Corporation, and the US Fish and Wildlife Service. Additional graduate monies were awarded to L.E.D. by Bat Conservation International, the University of Kentucky, and Sigma Xi. The authors declare they have no conflict of interest. We thank the USDA Forest Service, Mead-westvaco Corporation, Ohio Department of Natural Resources, Tennessee Wildlife Resources Agency, Forest Land Group, and Wagner Forest Management for providing study areas and implementing treatments. We thank Keith Summerville and an anonymous reviewers for constructive comments on earlier drafts of this manuscript. This study was conducted in accordance with the laws of the United States of America. This is paper 11-08-017 of the Kentucky Agricultural Experiment Station and is published with the approval of the director. NR 57 TC 20 Z9 22 U1 7 U2 88 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD MAR 1 PY 2012 VL 267 BP 262 EP 270 DI 10.1016/j.foreco.2011.12.016 PG 9 WC Forestry SC Forestry GA 904SU UT WOS:000301219000026 ER PT J AU Houston, JR Dean, RG AF Houston, James R. Dean, Robert G. TI Discussion of: Baart, F.; van Koningsveld, M., and Stive, M., 2012. Trends in Sea-Level Trend Analysis. Journal of Coastal Research, 28(2), 311-315 SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material ID ACCELERATION C1 [Houston, James R.] USA, Engineer Res & Dev Ctr, Corps Engn, Washington, DC 20314 USA. [Dean, Robert G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. RP Houston, JR (reprint author), USA, Engineer Res & Dev Ctr, Corps Engn, Washington, DC 20314 USA. EM james.r.houston@usace.army.mil; dean@coastal.ufl NR 5 TC 0 Z9 0 U1 0 U2 3 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD MAR PY 2012 VL 28 IS 2 BP 527 EP 527 DI 10.2112/JCOASTRES-11A-00025.1 PG 1 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 906EW UT WOS:000301328700022 ER PT J AU Brunye, TT Mahoney, CR Rapp, DN Ditman, T Taylor, HA AF Brunye, Tad T. Mahoney, Caroline R. Rapp, David N. Ditman, Tali Taylor, Holly A. TI Caffeine Enhances Real-World Language Processing: Evidence From a Proofreading Task SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-APPLIED LA English DT Article DE caffeine; arousal; language; discourse cohesion ID AUDITORY SENTENCE COMPREHENSION; RIGHT-HEMISPHERE ACTIVATION; EVENT-RELATED FMRI; TEXT COMPREHENSION; FRONTOPARIETAL NETWORK; COGNITIVE PERFORMANCE; TEMPORAL CORTEX; WORKING-MEMORY; CEREBRAL HEMISPHERES; SELECTIVE ATTENTION AB Caffeine has become the most prevalently consumed psychostimulant in the world, but its influences on daily real-world functioning are relatively unknown. The present work investigated the effects of caffeine (0 mg, 100 mg, 200 mg, 400 mg) on a commonplace language task that required readers to identify and correct 4 error types in extended discourse: simple local errors (misspelling 1- to 2-syllable words), complex local errors (misspelling 3- to 5-syllable words), simple global errors (incorrect homophones), and complex global errors (incorrect subject-verb agreement and verb tense). In 2 placebo-controlled, double-blind studies using repeated-measures designs, we found higher detection and repair rates for complex global errors, asymptoting at 200 mg in low consumers (Experiment 1) and peaking at 400 mg in high consumers (Experiment 2). In both cases, covariate analyses demonstrated that arousal state mediated the relationship between caffeine consumption and the detection and repair of complex global errors. Detection and repair rates for the other 3 error types were not affected by caffeine consumption. Taken together, we demonstrate that caffeine has differential effects on error detection and repair as a function of dose and error type, and this relationship is closely tied to caffeine's effects on subjective arousal state. These results support the notion that central nervous system stimulants may enhance global processing of language-based materials and suggest that such effects may originate in caffeine-related right hemisphere brain processes. Implications for understanding the relationships between caffeine consumption and real-world cognitive functioning are discussed. C1 [Brunye, Tad T.; Mahoney, Caroline R.] USA, NSRDEC, Cognit Sci Team, Natick, MA 01760 USA. [Brunye, Tad T.; Mahoney, Caroline R.; Ditman, Tali; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Rapp, David N.] Northwestern Univ, Sch Educ & Social Policy, Evanston, IL 60208 USA. [Rapp, David N.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA. [Ditman, Tali] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA. RP Brunye, TT (reprint author), USA, NSRDEC, Cognit Sci Team, 15 Kansas St, Natick, MA 01760 USA. EM tbrunye@alumni.tufts.edu NR 148 TC 9 Z9 9 U1 4 U2 17 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1076-898X J9 J EXP PSYCHOL-APPL JI J. Exp. Psychol.-Appl. PD MAR PY 2012 VL 18 IS 1 BP 95 EP 108 DI 10.1037/a0025851 PG 14 WC Psychology, Applied SC Psychology GA 908CO UT WOS:000301468200006 PM 21988325 ER PT J AU Blount, CA Leser, C AF Blount, Christopher A. Leser, Casey TI Multisystem Complications Following Endodontic Therapy SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; EXPERIMENTAL DIABETES-MELLITUS; RESPIRATORY-DISTRESS; COLLAGEN; BONE; IMPLANTS; RAT C1 [Blount, Christopher A.; Leser, Casey] Tripler Army Med Ctr, OMS Residency Program, Honolulu, HI 96859 USA. [Leser, Casey] Hunter Holmes McGuire VA Med Ctr, Richmond, VA USA. RP Blount, CA (reprint author), 5 Blackberry Lane, Amherst, MA 01002 USA. EM blount73@yahoo.com NR 24 TC 1 Z9 1 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD MAR PY 2012 VL 70 IS 3 BP 527 EP 530 DI 10.1016/j.joms.2011.08.039 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 908QN UT WOS:000301505300024 PM 22137296 ER PT J AU Elyassi, AR Prenzel, R Closmann, JJ AF Elyassi, Ali R. Prenzel, Ronald Closmann, James J. TI Pott Puffy Tumor After Maxillary Tooth Extraction SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID FRONTAL SINUSITIS; OSTEOMYELITIS C1 [Elyassi, Ali R.; Prenzel, Ronald; Closmann, James J.] Tripler Army Med Ctr, Dept Oral & Maxillofacial Surg, Honolulu, HI 96859 USA. RP Elyassi, AR (reprint author), 2500 Mugho Dr, Harker Hts, TX 76548 USA. EM aelyassi@gmail.com NR 17 TC 1 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD MAR PY 2012 VL 70 IS 3 BP E190 EP E192 DI 10.1016/j.joms.2011.11.018 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 908QN UT WOS:000301505300003 PM 22374061 ER PT J AU Henry, P Foots, A AF Henry, Paula Foots, Ashley TI Comparison of User Volume Control Settings for Portable Music Players with Three Earphone Configurations in Quiet and Noisy Environments SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE Music; noise; portable media players; preferred listening levels; recreational noise exposure ID SOUND-PRESSURE LEVELS; INDUCED HEARING-LOSS; COLLEGE-STUDENTS; LISTENING LEVELS; MP3 PLAYER; EXPOSURE; SYSTEMS AB Background: Listening to music is one of the most common forms of recreational noise exposure. Previous investigators have demonstrated that maximum output levels from headphones can exceed safe levels. Although preferred listening levels (PLL) in quiet environments may be at acceptable levels, the addition of background noise will add to the overall noise exposure of a listener. Use of listening devices that block out some of the background noise would potentially allow listeners to select lower PLLs for their music. Although one solution is in-the-ear earphones, an alternative solution is the use of earmuffs in conjunction with earbuds. Purpose: There were two objectives to this experiment. The first was to determine if an alternative to in-the-ear earphones for noise attenuation (the addition of earmuffs to earbuds) would allow for lower PLLs through a portable media player (PMP) than earbuds. The second was to determine if a surrounding background noise would yield different PLLs than a directional noise source. Research Design: This was an experimental study. Study Sample: Twenty-four adults with normal hearing. Data Collection and Analysis: PLLs were measured for three earphone configurations in three listening conditions. The earphone configurations included earbuds, canal earphones, and earbuds in combination with hearing protection devices (HPDs). The listening conditions included quiet, noise from one loudspeaker, and noise from four surrounding loudspeakers. Participants listened in each noise and earphone combination for as long as they needed to determine their PLL for that condition. Once the participant determined their PLL, investigators made a 5 sec recording of the music through a probe tube microphone. The average PLLs in each noise and earphone combination were used as the dependent variable. Ear canal level PLLs were converted to free-field equivalents to compare to noise exposure standards and previously published data. Results: The average PLL as measured in the ear canal was 74 dBA in the quiet conditions and 84 dBA in the noise conditions. Paired comparisons of the PLL in the presence of background noise for each pair of earphone configurations indicated significant differences for each comparison. An inverse relationship was observed between attenuation and PLL whereby the greater the attenuation, the lower the PLL. A comparison of the single noise source condition versus the surrounding noise condition did not result in a significant effect. Conclusion: The present work suggests that earphones that take advantage of noise attenuation can reduce the level at which listeners set music in the presence of background noise. An alternative to in-the-ear earphones for noise attenuation is the addition of earmuffs to earbuds. C1 [Henry, Paula; Foots, Ashley] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Henry, P (reprint author), RDRL HRS D, Bldg 520,Room 22, Aberdeen Proving Ground, MD 21005 USA. EM paula.p.henry.civ@mail.mil NR 31 TC 4 Z9 7 U1 0 U2 9 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD MAR PY 2012 VL 23 IS 3 BP 182 EP 191 DI 10.3766/jaaa.23.3.5 PG 10 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 912BD UT WOS:000301767500004 PM 22436116 ER PT J AU Lindler, L Lesho, EP Harms, DE Myers, TE Gaydos, JC AF Lindler, Luther Lesho, Emil P. Harms, Dan E. Myers, Todd E. Gaydos, Joel C. TI Influenza and Wound Infections: Laboratory Support for Deployed U.S. Forces SO MILITARY MEDICINE LA English DT Editorial Material ID SURVEILLANCE; IRAQ C1 [Lindler, Luther] Dept Homeland Secur, Washington, DC USA. [Lesho, Emil P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Harms, Dan E.] Tricare Management Agcy, Falls Church, VA USA. [Myers, Todd E.] USN, Med Res Ctr, Silver Spring, MD USA. [Gaydos, Joel C.] USAF, Hlth Surveillance Ctr, Silver Spring, MD USA. RP Lindler, L (reprint author), Dept Homeland Secur, Washington, DC USA. RI Valle, Ruben/A-7512-2013 NR 6 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 245 EP 247 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500002 PM 22479910 ER PT J AU Vincent, AS Roebuck-Spencer, T Lopez, MS Twillie, DA Logan, BW Grate, SJ Friedl, KE Schlegel, RE Gilliland, K AF Vincent, Andrea S. Roebuck-Spencer, Tresa Lopez, Mary S. Twillie, David A. Logan, Bret W. Grate, Stephen J. Friedl, Karl E. Schlegel, Robert E. Gilliland, Kirby TI Effects of Military Deployment on Cognitive Functioning SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MULTIPLE-SCLEROSIS; SPORTS CONCUSSION; IRAQ-WAR; PERFORMANCE; COMBAT; STRESS; TESTS AB Military deployment poses many risks for cognitive functioning. When deployed individuals are compared to a nondeployed control group, there is some evidence that deployment may be associated with declines in cognitive functioning. The current study examined cognitive performance before and following deployment in a large sample of active duty military personnel (N = 8,002) who reported no traumatic brain injury (TBI). Cognition was assessed using the Automated Neuropsychological Assessment Metrics version 4 TBI Military (ANAM4 TBI-MIL) battery, a computer-based battery of tests measuring attention, processing speed, and general cognitive efficiency. Pre- and postdeployment scores were compared using repeated measures analyses. Although statistically significant differences were observed for all tests (with 5 of 7 tests demonstrating performance improvement), effect sizes were very small for all but I test, indicating that performance differences had minimal clinical significance. Likewise, determination of change for individuals using reliable change indices revealed that a very small percentage (<3%) of this presumed healthy sample showed meaningful decline in cognition following deployment. Analyses indicated that despite risks for cognitive decline while in theater, deployment had minimal to no lasting effect on cognition as measured by ANAM4 TBI-Mil upon return from deployment. C1 [Vincent, Andrea S.; Roebuck-Spencer, Tresa; Schlegel, Robert E.; Gilliland, Kirby] Univ Oklahoma, Cognit Sci Res Ctr, Norman, OK 73072 USA. [Lopez, Mary S.] US Army Bavaria Med Dept Act BMEDDAC, Rose Barracks, Vilseck, Germany. [Twillie, David A.; Logan, Bret W.] Blanchfield Army Community Hosp, Ft Campbell, KY 42223 USA. [Grate, Stephen J.; Friedl, Karl E.] USA, Telemed & Adv Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Vincent, AS (reprint author), Univ Oklahoma, Cognit Sci Res Ctr, 3200 Marshall Ave,Suite 260, Norman, OK 73072 USA. OI Friedl, Karl/0000-0002-3134-8427 FU DoD; Telemedicine & Advanced Technology Research Center (TATRC) at Fort Detrick [W8IXWH-07-2-0097] FX This data analysis was conducted by the Cognitive Science Research Center (CSRC) at the University of Oklahoma and is made possible by a DoD Grant awarded and administered by the U.S. Army Medical Research & Materiel Command (USAMRMC) and the Telemedicine & Advanced Technology Research Center (TATRC) at Fort Detrick, MD, under contract number W8IXWH-07-2-0097. NR 46 TC 11 Z9 11 U1 2 U2 12 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 248 EP 255 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500003 PM 22479911 ER PT J AU Cabrera, JL Wilks, EG Symons, JE Blankson, KL Cole, RE AF Cabrera, Jorge L. Wilks, Edward G. Symons, Jenna E. Blankson, Kwabena L. Cole, Renee E. TI Multidisciplinary Intervention With Sibutramine: Assessing Successful Weight Loss Predictors in Military Adolescent Dependents SO MILITARY MEDICINE LA English DT Article ID CARDIOVASCULAR OUTCOMES; METABOLIC SYNDROME; OBESE ADOLESCENTS; YOUNG ADULTHOOD; EATING-DISORDER; US ADOLESCENTS; UNITED-STATES; DOUBLE-BLIND; OVERWEIGHT; TRIAL AB Objectives: Assess body mass index (BMI) reduction through a multidisciplinary intervention with sibutramine in adolescents of military parents and examine characteristics and behavioral traits as predictors of successful weight loss. Methods: A prospective study where participants received sibutramine daily for 6 months. Adolescents ages 12 to 18 with BMI-for-age and sex greater than 95 percentile and good health were enrolled. Outcome variables are BMI, biochemical indices, and clinical measurements. Predictor variables are participant demographics, family history, lifestyle changes, and behavioral traits assessed with behavioral assessment for children. Results: One hundred participants were recruited with 81% completion. In those participants who completed the 6-month intervention, a mean participant BMI reduction of 3.1 kg/m(2) (-9.3%) (p < 0.001; 95% CI: 10.5% to 7.9%) was obtained with 79% successfully meeting the weight loss goal. Sibutramine dose was increased from 10 to 15 mg at 3 months for participant with <2.5% BMI reduction from baseline. Sibutramine dose at 3 months (p < 0.001) and participants perception of relationship with parents (p = 0.05) were statistically significant predictors of successful weight loss (>= 10% reduction in BMI). Conclusions: Sibutramine was effective at promoting minimum beneficial BMI reduction of 5% in adolescents with service-connected parents; however, increasing dosage at 3 months did not improve the likelihood of being successful. C1 [Cabrera, Jorge L.] Madigan Army Med Ctr, Lewis Mcchord, WA 98431 USA. [Wilks, Edward G.; Symons, Jenna E.] Brooke Army Med Ctr, Dept Behav Med, Ft Sam Houston, TX 78234 USA. [Blankson, Kwabena L.] Brooke Army Med Ctr, SAUSHEC Adolescent Med Fellowship, Ft Sam Houston, TX 78234 USA. [Cole, Renee E.] USA, US Mil Dietet Internship Consortium Program, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Cabrera, JL (reprint author), Madigan Army Med Ctr, 9040 Fitzsimmons Dr, Lewis Mcchord, WA 98431 USA. FU Telemedicine & Advanced Technology Research Center through the AMEDD Advanced Medical Technology Initiative FX We thank MAJ Jeffrey Livezey, LTC Debra Hemandez, LT Trinity Storey, LTC David Bush, Janie Garcia, Cristy Landt, Gerald Merrell, and the Department of Clinical Investigations at BAMC for their assistance in conducting the protocol, reviews, and suggestions. Sibutramine was funded through the BAMC and Wilford Hall Medical Center Pharmacies. This study was also supported by Telemedicine & Advanced Technology Research Center through the AMEDD Advanced Medical Technology Initiative. NR 41 TC 0 Z9 0 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 308 EP 314 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500011 PM 22479919 ER PT J AU Suay, RN de Barbara, AHA Ortega, CG Cela, LCEB Lam, DM Rodriguez, FG AF Navarro Suay, Ricardo Hernandez Abadia de Barbara, Alberto Gutierrez Ortega, Carlos Bartolome Cela, Lieutenant Colonel Enrique Lam, David M. Gilsanz Rodriguez, Fernando TI Gunshot and Improvised Explosive Casualties: A Report From the Spanish Role 2 Medical Facility in Herat, Afghanistan SO MILITARY MEDICINE LA English DT Article ID INJURY AB Objective: To provide an analysis of casualties treated during medical evacuation (MEDEVAC) or/and at the Spanish Role 2 in Herat, Afghanistan, including type of weapon, injuries, and effects of protective measures. Method: A retrospective analysis was carried out concerning patients who had suffered injuries from either gunshot or explosive devices treated during MEDEVAC or/and at this facility during the period 2005-2008. Results: The total number of cases analyzed was 256. The majority of the casualties were produced by explosive devices (71%). The anatomical regions most affected were the lower limbs (48%). There was a higher New Injury Severity Score in casualties wounded by gunshot (14 +/- 1) than in those wounded by explosive devices (8.5 +/- 1.5) (p < 0.001). Surgical procedures for injuries caused by gunshots were 1.7 times more likely than for those due to explosive devices (95% confidence interval: 1.4 to 2.1). Protective devices were used only by 25% of casualties. Conclusions: The injury score indices of firearm casualties were higher than the explosive device casualties' injury score indices. The possible reasons for this finding are discussed. C1 [Navarro Suay, Ricardo] Escuela Mil Sanidad, Grp Escuelas Def, Madrid, Spain. [Hernandez Abadia de Barbara, Alberto; Gutierrez Ortega, Carlos; Bartolome Cela, Lieutenant Colonel Enrique] Hosp Cent Def Gomez Ulla, Madrid, Spain. [Lam, David M.] USA, FOR LAM, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Lam, David M.] Univ Maryland, Sch Med, Natl Study Ctr Trauma & Emergency Med Serv, Baltimore, MD 21201 USA. [Gilsanz Rodriguez, Fernando] Hosp Univ La Paz, Madrid, Spain. RP Suay, RN (reprint author), Escuela Mil Sanidad, Grp Escuelas Def, Camino Ingenieros 6,CP 28071, Madrid, Spain. NR 9 TC 2 Z9 3 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 326 EP 332 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500014 PM 22479922 ER PT J AU Hanlon, E Gillich, P AF Hanlon, Erin Gillich, Patrick TI Origin of the 44-mm Behind-Armor Blunt Trauma Standard SO MILITARY MEDICINE LA English DT Article ID INJURY; IMPACT; PROTECTION; CRITERIA; CHEST AB A number of armed assaults on public officials occurred in the early 1970s, which prompted the Lightweight Soft Body Armor Program to develop modern, concealable, soft body armor. Methodology needed to be developed to (1) determine the effectiveness of the soft body armor to stop bullet penetration and (2) assess the potential injury from nonpenetrating blunt impacts to the body. Extensive research was performed under the program to develop methodologies to assess soft body armor, including behind-armor blunt trauma (BABT) evaluation. This methodology is still used today, and it has been applied extensively beyond the original intent. However, the origin of this methodology is not well understood by many researchers in the various fields in which it is being applied because the original documentation is difficult to obtain. Therefore, the purpose of this article is to provide a comprehensive review of the BABT to offer researchers information about its history and limitations. C1 [Hanlon, Erin; Gillich, Patrick] USA, Res Lab, RDRL SLB W, Aberdeen Proving Ground, MD 21005 USA. RP Hanlon, E (reprint author), USA, Res Lab, RDRL SLB W, 328 Hopkins Rd, Aberdeen Proving Ground, MD 21005 USA. FU U.S. Army Research Laboratory; US Army Research Laboratory's Survivability/Lethality Analysis Directorate FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. The research was funded internally through the US Army Research Laboratory's Survivability/Lethality Analysis Directorate. NR 36 TC 3 Z9 3 U1 2 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 333 EP 339 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500015 PM 22479923 ER PT J AU Burgert, J Gegel, B Neal, AR Kammer, KE Paul, ME Schwartz, DJ Loughren, M Johnson, A AF Burgert, James Gegel, Brian Neal, Ann R. Kammer, Karl E. Paul, Martha E. Schwartz, Daniel J. Loughren, Michael Johnson, Arthur TI The Effects of Arterial Blood Pressure on Rebleeding When BleedArrest, Celox and Traumadex are Used in a Porcine Model of Lethal Femoral Injury SO MILITARY MEDICINE LA English DT Article ID FLUID RESUSCITATION; HEMOSTATIC AGENTS; HEMORRHAGIC-SHOCK; SWINE; BATTLEFIELD; SURVIVAL AB Uncontrolled bleeding remains the leading cause of preventable death in trauma. Hemostatic agents are effective in hemorrhage control but often fail following high-volume crystalloid resuscitation. Aggressive fluid resuscitation increases the blood pressure which may dislodge the newly formed clot causing rebleeding. The purpose of this study was to determine the systolic blood pressure (SBP) and the mean arterial pressure (MAP) at which rebleeding occurs when a clot is formed by one of these hemostatic agents (Bleed Arrest, TraumaDex, or Celox) compared to a control group. This was a prospective, experimental study using male 5 Yorkshire swine per group (Bleed Arrest, TraumaDex, Celox, or control). The femoral artery and vein were transected to simulate a traumatic injury. Subjects were allowed to bleed for 60 seconds then one of the agents was poured into the wound. The control group underwent the same procedures but without the hemostatic agent. After 30 minutes, dressings were removed and the SBP was increased incrementally using intravenous phenylephrine until rebleeding occurred or until the arterial blood pressure reached 210 mm/Hg. The SBP and MAP were significantly higher in the Bleed Arrest, Trauma Dex, and Celox groups compared to a control group (p < 0.05). C1 [Burgert, James] Brooke Army Med Ctr, Dept Anesthesia, San Antonio, TX 78234 USA. [Gegel, Brian; Neal, Ann R.; Kammer, Karl E.; Paul, Martha E.; Schwartz, Daniel J.; Loughren, Michael; Johnson, Arthur] USA, Grad Program Anesthesia, Dept Army Acad Hlth Sci, Ft Sam Houston, TX 78234 USA. RP Burgert, J (reprint author), Brooke Army Med Ctr, Dept Anesthesia, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. FU TriService Nursing Research Program; University of Texas Health Science Center at San Antonio FX We would like to acknowledge the TriService Nursing Research Program and the staff at the University of Texas Health Science Center at San Antonio for their support. NR 26 TC 2 Z9 2 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 340 EP 344 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500016 PM 22479924 ER PT J AU Safi, N Davis, GD Nadir, M Hamid, H Robert, LL Case, AJ AF Safi, Najibullah Davis, Gary D. Nadir, Mohammed Hamid, Hamida Robert, Leon L., Jr. Case, Alan J. TI Evaluation of Thermotherapy for the Treatment of Cutaneous Leishmaniasis in Kabul, Afghanistan: A Randomized Controlled Trial SO MILITARY MEDICINE LA English DT Article AB Anthroponotic cutaneous leishmaniasis (CL) is a common cause of ulcerative lesions and disfiguring scarring among children in Afghanistan. Most lesions occur on the face and are commonly caused by the trypanosome protozoan parasite Leishmania tropica, transmitted by the bite of an infected sandfly (Phlebotomus sergenti). This study compared the effectiveness of a single localized treatment with thermotherapy to 5 days of intralesional administration of Glucantime for the treatment of CL. Three hundred and eighty-two patients with CL were randomly assigned to the two treatment groups and followed for 6 months. The cure rate for the thermotherapy group was 82.5%, compared to 74% in the Glucantime group. The authors concluded that a single localized treatment with thermotherapy was more effective than 5 days of intralesional administration of Glucantime. Additionally, thermotherapy was more cost-effective, with fewer side effects, of shorter duration, and with better patient compliance than intralesional Glucantime. C1 [Safi, Najibullah] UNOCA Compound, World Hlth Org Country Off, Dept Primary Hlth Care, Kabul, Afghanistan. [Davis, Gary D.; Case, Alan J.] Combined Training Advisory Grp Army CSTC A, NATO Training Mission Afghanistan NTM A, MTAG, APO, AE 09356 USA. [Nadir, Mohammed] UNOCA Compound, World Hlth Org Country Off, Communicable Dis Surveillance & Response Dept, Kabul, Afghanistan. [Hamid, Hamida] Res Dept, Natl Malaria & Leishmaniasis Control Program, Kabul, Afghanistan. [Robert, Leon L., Jr.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. RP Safi, N (reprint author), UNOCA Compound, World Hlth Org Country Off, Dept Primary Hlth Care, Jalalabad Rd, Kabul, Afghanistan. NR 18 TC 14 Z9 14 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 2012 VL 177 IS 3 BP 345 EP 351 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 906CW UT WOS:000301323500017 PM 22479925 ER PT J AU Kilcoyne, CPTKG Dickens, CPTJF Haniuk, E Cameron, KL Owens, LTCBD AF Kilcoyne, C. P. T. Kelly G. Dickens, C. P. T. Jonathan F. Haniuk, Erik Cameron, Kenneth L. Owens, L. T. C. Brett D. TI Epidemiology of Meniscal Injury Associated With ACL Tears in Young Athletes SO ORTHOPEDICS LA English DT Article ID CRUCIATE LIGAMENT INJURY; DEFICIENT KNEE; HIGH-SCHOOL; PATTERNS; ARTHROSCOPY; BASKETBALL; LESIONS; GENDER; SOCCER; WOMEN AB The epidemiologic characteristics of concomitant meniscal tears that occur at the time of anterior cruciate ligament (ACL) injury have been variably reported. The purpose of this study was to assess the epidemiology of meniscal tears that occur in the ACL-injured knee of a young, athletic population at a single institution. We were unable to find a difference in meniscal tear incidence based on sex, mechanism of injury, sport, or time to surgery. In addition, we found that the cumulative incidence of isolated medial meniscal tears was significantly higher than the cumulative incidence of isolated lateral meniscal tears. Our prospective study design and ability to identify and follow all patients in our study population make this a unique study. C1 [Kilcoyne, C. P. T. Kelly G.; Dickens, C. P. T. Jonathan F.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed, Washington, DC 20012 USA. [Haniuk, Erik; Cameron, Kenneth L.; Owens, L. T. C. Brett D.] Keller Army Hosp, West Point, NY USA. RP Kilcoyne, CPTKG (reprint author), Walter Reed Natl Mil Med Ctr, Dept Orthopaed, 6900 Georgia Ave NW, Washington, DC 20012 USA. EM kelly.kilcoyne@med.navy.mil OI Cameron, Kenneth/0000-0002-6276-4482 NR 16 TC 3 Z9 3 U1 1 U2 9 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD MAR PY 2012 VL 35 IS 3 BP 208 EP 212 DI 10.3928/01477447-20120222-07 PG 5 WC Orthopedics SC Orthopedics GA 908PE UT WOS:000301501500039 ER PT J AU Moore, SE Stafford, KM Melling, H Berchok, C Wiig, O Kovacs, KM Lydersen, C Richter-Menge, J AF Moore, Sue E. Stafford, Kathleen M. Melling, Humfrey Berchok, Catherine Wiig, Oystein Kovacs, Kit M. Lydersen, Christian Richter-Menge, Jackie TI Comparing marine mammal acoustic habitats in Atlantic and Pacific sectors of the High Arctic: year-long records from Fram Strait and the Chukchi Plateau SO POLAR BIOLOGY LA English DT Article DE Marine mammals; Acoustics; Seismic surveys; International Polar Year ID LOW-FREQUENCY WHALE; BOWHEAD WHALES; SOUNDS; WATER; HEAT AB During the International Polar Year (IPY), acoustic recorders were deployed on oceanographic moorings in Fram Strait and on the Chukchi Plateau, representing the first coordinated year-round sampling of underwater acoustic habitats at two sites in the High Arctic. Examination of species-specific marine mammal calls recorded from autumn 2008-2009 revealed distinctly different acoustic habitats at each site. Overall, the Fram Strait site was acoustically complex compared with the Chukchi Plateau site. In Fram Strait, calls from bowhead whales (Balaena mysticetus) and a variety of toothed whales (odontocetes) were recorded year-round, as were airgun pulses from seismic surveys. In addition, calls from blue whales (Balaenoptera musculus) and fin whales (B. physalus) were recorded from June to October and August to March, respectively. Conversely, at the Chukchi Plateau site, beluga (Delphinapterus leucas) and bowhead whale calls were recorded primarily from May to August, with airgun signals detected only in September-October. Ribbon seal (Phoca fasciata) calls were detected in October-November, with no marine mammals calls at all recorded from December to February. Of note, ice-adapted bearded seals (Erignathus barbatus) were recorded at both sites, primarily in spring and summer, corresponding with the mating season for that species. Differences in acoustic habitats between the two sites were related to contrasts in sea ice cover, temperature, patterns of ocean circulation and contributions from anthropogenic noise sources. These data provide a provisional baseline for the comparison of underwater acoustic habitats between Pacific and Atlantic sectors of the High Arctic. C1 [Moore, Sue E.] NOAA, Off Sci & Technol, Natl Marine Fisheries Serv, Seattle, WA 98115 USA. [Stafford, Kathleen M.] Univ Washington, Appl Phys Lab, Seattle, WA 98105 USA. [Melling, Humfrey] Fisheries & Oceans Canada, Sidney, BC V8L 4B2, Canada. [Berchok, Catherine] NOAA, Alaska Fisheries Sci Ctr, Seattle, WA 98115 USA. [Wiig, Oystein] Univ Oslo, Nat Hist Museum, Natl Ctr Biosystemat, N-0318 Oslo, Norway. [Kovacs, Kit M.; Lydersen, Christian] Norwegian Polar Res Inst, N-9296 Tromso, Norway. [Richter-Menge, Jackie] ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Moore, SE (reprint author), NOAA, Off Sci & Technol, Natl Marine Fisheries Serv, 7600 Sand Point Way NE, Seattle, WA 98115 USA. EM sue.moore@noaa.gov RI Wiig, Oystein/J-8383-2012 OI Wiig, Oystein/0000-0003-0395-5251 FU NOAA/Fisheries; NOAA/OAR; Fisheries and Oceans Canada; Norwegian Polar Institute for at-sea capability FX We thank the Canadian Coast Guard, the Norwegian Polar Institute and all the scientists, technical staff and crews aboard the Sir Wilfrid Laurier and the R/V Lance for their assistance in recorder deployment and recovery. We also thank the NOAA/Fisheries (B. Southall) and the NOAA/OAR (J. Calder) line offices for funding, as well as Fisheries and Oceans Canada and the Norwegian Polar Institute for at-sea capability, in-kind support and encouragement. NR 26 TC 27 Z9 28 U1 5 U2 33 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0722-4060 J9 POLAR BIOL JI Polar Biol. PD MAR PY 2012 VL 35 IS 3 BP 475 EP 480 DI 10.1007/s00300-011-1086-y PG 6 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 907XI UT WOS:000301452600015 ER PT J AU Jiang, J Stromdahl, EY Richards, AL AF Jiang, Ju Stromdahl, Ellen Y. Richards, Allen L. TI Detection of Rickettsia parkeri and Candidatus Rickettsia andeanae in Amblyomma maculatum Gulf Coast Ticks Collected from Humans in the United States SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Amblyomma maculatum; Candidatus Rickettsia andeanae; Gulf Coast Tick; Quantitative real-time PCR Assays; Rickettsia parkeri; Spotted Fever Rickettsioses ID FEVER GROUP RICKETTSIAE; MOUNTAIN-SPOTTED-FEVER; NORTHERN PERU; INFECTION; FLEA; PREVALENCE; FELIS; BORNE; ANTIBODIES; VIRGINIA AB Rickettsia parkeri, a spotted fever group (SFG) rickettsia recently found to be pathogenic to humans, causes an eschar-associated febrile illness. The R. parkeri rickettsiosis, Tidewater spotted fever, has been misdiagnosed as Rocky Mountain spotted fever due to serologic cross reactivity and the lack of specific diagnostic methods. Candidatus Rickettsia andeanae, also a SFG rickettsia, is a recently described agent of unknown pathogenicity originally identified in ticks collected from domestic animals during a fever outbreak investigation in northern Peru. Among 37 Amblyomma maculatum (collected from humans (n = 35) and questing (n = 2)) obtained from the southern United States during 2000-2009, nine and four A. maculatum nucleic acid preparations were found positive for R. parkeri and Candidatus R. andeanae, respectively, by newly developed genus-and species-specific quantitative real-time polymerase chain reaction assays. In addition Rickettsia felis was found in two A. maculatum nucleic acid preparations. C1 [Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Stromdahl, Ellen Y.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Richards, AL (reprint author), USN, Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM allen.richards@med.navy.mil RI Valle, Ruben/A-7512-2013 FU AFHSC-GEIS [0000188M.0931.001.A0074] FX The work reported herein was supported by the AFHSC-GEIS program, and its work unit number was 0000188M.0931.001.A0074. The opinions and assertions contained in this article are the private ones of the authors and are not to be construed as official or reflecting the views of the Navy Department, Army Department, or the Department of Defense at large. The authors, as employees of the U.S. Government, conducted the work as part of their official duties. Title 17 U.S.C. 105 provides that "Copyright protection under this title is not available for any work of the U.S. Government." Title 17 U.S.C 101 defines a U.S. Government work as a work prepared by an employee of the U.S. Government as part of the person's official duties. The authors thank Mary Vince at USACHPPM for her technical help. NR 44 TC 43 Z9 43 U1 0 U2 13 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD MAR PY 2012 VL 12 IS 3 BP 175 EP 182 DI 10.1089/vbz.2011.0614 PG 8 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 906NX UT WOS:000301353600001 PM 22022815 ER PT J AU Sensenig, RA Murray, CK Mende, K Wolf, SE Chung, KK Hospenthal, DR Yun, HC AF Sensenig, Rebekah A. Murray, Clinton K. Mende, Katrin Wolf, Steven E. Chung, Kevin K. Hospenthal, Duane R. Yun, Heather C. TI Longitudinal characterization of Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonizing and infecting combat casualties SO AMERICAN JOURNAL OF INFECTION CONTROL LA English DT Article DE Colonization; Multidrug resistant; Acinetobacter baumannii-calcoaceticus complex; Klebsiella pneumoniae; Methicillin-resistant Staphylococcus aureus; MRSA ID IRAQ AB Drug-resistant Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonize and infect combat casualties from Iraq and Afghanistan. We retrospectively evaluated relatedness, by pulsed-field gel electrophoresis and antibiotic susceptibility testing, of isolates colonizing and infecting casualties over 2 years. Colonizing organisms were unrelated to isolates producing later infection in up to 27% of cases; most isolates underwent change in antibiotic susceptibilities. The same is true for serial infecting isolates recovered during hospitalization. Published by Elsevier Inc. on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc. C1 [Yun, Heather C.] USAF MC, Infect Dis Serv, Brooke Army Med Ctr, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Hospenthal, Duane R.; Yun, Heather C.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Mende, Katrin] Uniformed Serv Univ Hlth Sci, Dept Infect Dis, Clin Res Program, Bethesda, MD 20814 USA. [Wolf, Steven E.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Yun, HC (reprint author), USAF MC, Infect Dis Serv, Brooke Army Med Ctr, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM heather.yun@amedd.army.mil RI Valle, Ruben/A-7512-2013; OI Wolf, Steven/0000-0003-2972-3440 FU Global Emerging Infections Surveillance and Response System; Uniformed Services University of the Health Sciences (USUHS); Division of the Armed Forces Health Surveillance Center FX Supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center, and by the Infectious Disease Clinical Research Program (IDCRP), of the Uniformed Services University of the Health Sciences (USUHS). NR 7 TC 3 Z9 3 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-6553 J9 AM J INFECT CONTROL JI Am. J. Infect. Control PD MAR PY 2012 VL 40 IS 2 BP 183 EP 185 DI 10.1016/j.ajic.2011.03.025 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 899XK UT WOS:000300849800020 PM 21802175 ER PT J AU Driscoll, JJ Burris, J Annunziata, CM AF Driscoll, James J. Burris, Jason Annunziata, Christina M. TI Targeting the Proteasome With Bortezomib in Multiple Myeloma: Update on Therapeutic Benefit as an Upfront Single Agent, Induction Regimen for Stem-Cell Transplantation and as Maintenance Therapy SO AMERICAN JOURNAL OF THERAPEUTICS LA English DT Article DE multiple myeloma; bortezomib; monotherapy; stem-cell transplantation induction; maintenance therapy ID PHASE-II; INCORPORATING BORTEZOMIB; NEDD8-ACTIVATING ENZYME; COMBINATION THERAPY; PLUS DEXAMETHASONE; CLINICAL-OUTCOMES; TRIAL; EXPRESSION; LENALIDOMIDE; CHEMOTHERAPY AB Bortezomib is the first therapeutic inhibitor of the proteasome that has demonstrated a significant clinical response in patients with otherwise refractory or rapidly advancing disease. Bortezomib has received US Federal Drug Administration approval for the treatment of the hematologic malignancies such as multiple myeloma and mantle cell lymphoma. Herein, the use of bortezomib as an upfront therapy, as an induction regimen before stem-cell transplantation and as maintenance therapy in the treatment of multiple myeloma is discussed. C1 [Driscoll, James J.; Burris, Jason; Annunziata, Christina M.] NCI, Med Oncol Branch, Magnuson Canc Ctr, NIH,Translat Genom Sect, Bethesda, MD 20892 USA. [Burris, Jason] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA. RP Driscoll, JJ (reprint author), NCI, Med Oncol Branch, Magnuson Canc Ctr, NIH,Translat Genom Sect, 10 Ctr Dr,Bldg 10,Room 12N-226, Bethesda, MD 20892 USA. EM driscollj@mail.nih.gov RI Annunziata, Christina/L-3219-2016 OI Annunziata, Christina/0000-0003-2033-6532 FU Intramural NIH HHS [ZIA BC011312-02] NR 64 TC 4 Z9 4 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1075-2765 EI 1536-3686 J9 AM J THER JI Am. J. Ther. PD MAR PY 2012 VL 19 IS 2 BP 133 EP 144 DI 10.1097/MJT.0b013e3181ff7a9e PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 906GW UT WOS:000301333900017 PM 21248621 ER PT J AU Reinbold-Wasson, DD Sardelis, MR Jones, JW Watts, DM Fernandez, R Carbajal, F Pecor, JE Calampa, C Klein, TA Turell, MJ AF Reinbold-Wasson, Drew D. Sardelis, Michael R. Jones, James W. Watts, Douglas M. Fernandez, Roberto Carbajal, Faustino Pecor, James E. Calampa, Carlos Klein, Terry A. Turell, Michael J. TI Determinants of Anopheles Seasonal Distribution Patterns Across a Forest to Periurban Gradient near Iquitos, Peru SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HUMAN ATTRACTION PATTERNS; AMAZON BASIN REGION; MOSQUITOS DIPTERA; CENTRAL-AMERICA; MONOCLONAL-ANTIBODIES; ELISA DEVELOPMENT; MALARIA VECTOR; SOUTH-AMERICA; DARLINGI; CULICIDAE AB As part of a field ecology study of arbovirus and malaria activity in the Amazon Basin, Loreto Department, Peru, we collected mosquitoes landing on humans at a forest site and inside and outside of residences and military barracks at periurban, rural, and village sites. We collected 11 Anopheles spp. from these four sites. An. darlingi, the principal malaria vector in the region, accounted for 98.7% of all Anopheles spp. collected at Puerto Almendra. Peaks in landing activity occurred during the December and April collection periods. However, the percent of sporozoite-positive Anopheles spp. was highest 1-2 months later, when landing activity decreased to approximately 10% of the peak activity periods. At all sites, peak landing activity occurred about 2 hours after sunset. These data provide a better understanding of the taxonomy, population density, and seasonal and habitat distribution of potential malaria vectors within the Amazon Basin region. C1 [Turell, Michael J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. USN, Med Res Unit 6, Lima, Peru. Walter Reed Army Inst Res, Dept Entomol, Washington, DC USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@amedd.army.mil FU US Navy [62787A 870 U 8517] FX This study was supported in part by Work Unit Number 62787A 870 U 8517 of the US Navy. NR 29 TC 11 Z9 11 U1 0 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 2012 VL 86 IS 3 BP 459 EP 463 DI 10.4269/ajtmh.2012.11-0547 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 904AM UT WOS:000301166000015 PM 22403317 ER PT J AU Jin, QW Yu, L Lavery, JE Fang, SC AF Jin, Qingwei Yu, Lu Lavery, John E. Fang, Shu-Cherng TI Univariate cubic L-1 interpolating splines based on the first derivative and on 5-point windows: analysis, algorithm and shape-preserving properties SO COMPUTATIONAL OPTIMIZATION AND APPLICATIONS LA English DT Article DE Cubic L-1 spline; First-derivative-based; Interpolation; Locally calculated; Shape preservation ID GEOMETRIC-PROGRAMMING APPROACH; L-P SPLINES; MULTISCALE INTERPOLATION; SMOOTHING SPLINES; BIVARIATE AB In this paper, univariate cubic L-1 interpolating splines based on the first derivative and on 5-point windows are introduced. Analytical results for minimizing the local spline functional on 5-point windows are presented and, based on these results, an efficient algorithm for calculating the spline coefficients is set up. It is shown that cubic L-1 splines based on the first derivative and on 5-point windows preserve linearity of the original data and avoid extraneous oscillation. Computational examples, including comparison with first-derivative-based cubic L-1 splines calculated by a primal affine algorithm and with second-derivative-based cubic L-1 splines, show the advantages of the first-derivative-based cubic L-1 splines calculated by the new algorithm. C1 [Jin, Qingwei] Zhejiang Univ, Dept Management Sci & Engn, Hangzhou 310003, Zhejiang, Peoples R China. [Jin, Qingwei; Yu, Lu; Lavery, John E.; Fang, Shu-Cherng] N Carolina State Univ, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA. [Lavery, John E.] USA, Math Sci Div, Army Res Off, Res Lab, Res Triangle Pk, NC 27709 USA. RP Jin, QW (reprint author), Zhejiang Univ, Dept Management Sci & Engn, Hangzhou 310003, Zhejiang, Peoples R China. EM qjin2@ncsu.edu; lyu@ncsu.edu; john.e.lavery4.civ@mail.mil; fang@ncsu.edu FU US Army Research Office [W911NF-04-D-0003]; North Carolina State University; US NSF [DMI-0553310]; Army Research Office FX The authors would like to thank the anonymous reviewer and associate editor for the valuable comments to improve the quality of the paper. This work was generously supported by US Army Research Office Grant # W911NF-04-D-0003, by the North Carolina State University Edward P. Fitts Fellowship and by US NSF Grant # DMI-0553310. It is the policy of the Army Research Office that university personnel do not need to do joint work with ARO personnel in order to receive grants from the Army Research Office. NR 21 TC 0 Z9 0 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0926-6003 J9 COMPUT OPTIM APPL JI Comput. Optim. Appl. PD MAR PY 2012 VL 51 IS 2 BP 575 EP 600 DI 10.1007/s10589-011-9426-y PG 26 WC Operations Research & Management Science; Mathematics, Applied SC Operations Research & Management Science; Mathematics GA 904GA UT WOS:000301180900006 ER PT J AU Crum-Cianflone, NF Curry, J Drobeniuc, J Weintrob, A Landrum, M Ganesan, A Bradley, W Agan, BK Kamili, S AF Crum-Cianflone, Nancy F. Curry, Jennifer Drobeniuc, Jan Weintrob, Amy Landrum, Michael Ganesan, Anuradha Bradley, William Agan, Brian K. Kamili, Saleem CA Infectious Dis Clinical Res TI Hepatitis E Virus Infection in HIV-infected Persons SO EMERGING INFECTIOUS DISEASES LA English DT Article ID UNITED-STATES; ANTIBODIES AB To determine whether hepatitis E virus (HEV) is a cause of hepatitis among HIV-infected persons, we evaluated 1985-2009 data for US military beneficiaries. Evidence of acute or prior HEV infection was detected for 7 (4%) and 5 (3%) of 194 HIV-infected persons, respectively. HEV might be a cause of acute hepatitis among HIV-infected persons. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Curry, Jennifer; Weintrob, Amy; Landrum, Michael; Ganesan, Anuradha; Bradley, William; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Curry, Jennifer] USN, Med Ctr Portsmouth, Portsmouth, VA USA. [Drobeniuc, Jan; Kamili, Saleem] Ctr Dis Control & Prevent, Atlanta, GA USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Landrum, Michael] San Antonio Mil Med Ctr, San Antonio, TX USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Bethesda, MD USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, Suite 5,34800 Bob Wilson Dr, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU Uniformed Services University of the Health Sciences [IDCRP-000-21]; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072] FX Support for this work (IDCRP-000-21) was provided by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. NR 15 TC 33 Z9 33 U1 0 U2 1 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAR PY 2012 VL 18 IS 3 BP 502 EP 506 DI 10.3201/eid1803.111278 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 902FM UT WOS:000301024000023 PM 22377220 ER PT J AU Burton, GA Rosen, G Chadwick, DB Greenberg, MS Taulbee, WK Lotufo, GR Reible, DD AF Burton, G. Allen, Jr. Rosen, Gunther Chadwick, D. Bart Greenberg, Marc S. Taulbee, W. Keith Lotufo, Guilherme R. Reible, Danny D. TI A sediment ecotoxicity assessment platform for in situ measures of chemistry, bioaccumulation and toxicity. Part 1: System description and proof of concept SO ENVIRONMENTAL POLLUTION LA English DT Article DE Sediment contamination; Risk assessment; In situ ID MYTILUS-GALLOPROVINCIALIS; ORGANISMS; EXPOSURES; QUALITY; WATER AB In situ-based testing using aquatic organisms has been widely reported, but is often limited in scope and practical usefulness in making decisions on ecological risk and remediation. To provide this capability, an integrated deployment system, the Sediment Ecotoxicity Assessment (SEA) Ring was developed, which incorporates rapid in situ hydrological, chemical, bioaccumulation, and toxicological Lines-of-Evidence (LoE) for assessing sediment and overlying water contamination. The SEA Ring system allows for diver-assisted, or diverless, deployment of multiple species of ecologically relevant and indigenous organisms in three different exposures (overlying water, sediment-water interface, and bulk sediment) for periods ranging from two days to three weeks, in a range of water systems. Measured endpoints were both sublethal and lethal effects as well as bioaccumulation. In addition, integrated passive sampling devices for detecting nonpolar organics (solid phase micro-extraction fibers) and metals (diffusive gradients in thin films) provided gradient measures in overlying waters and surficial sediments. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Burton, G. Allen, Jr.] Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. [Rosen, Gunther; Chadwick, D. Bart] Space & Naval Warfare Syst Ctr Pacific, Environm Sci Branch, San Diego, CA 92152 USA. [Greenberg, Marc S.] US EPA, Edison, NJ 08837 USA. [Taulbee, W. Keith] Great Lakes Environm Ctr, Columbus, OH 43212 USA. [Lotufo, Guilherme R.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Reible, Danny D.] Univ Texas Austin, Austin, TX 78712 USA. RP Burton, GA (reprint author), Univ Michigan, Sch Nat Resources & Environm, Ann Arbor, MI 48109 USA. EM burtonal@umich.edu RI Burton, Glenn/Q-9714-2016 OI Burton, Glenn/0000-0002-8660-6294 FU Strategic Environmental Research and Development Program (SERDP) [ER-1550] FX This research was funded by a grant from the Strategic Environmental Research and Development Program (SERDP), under Project #ER-1550. The authors thank David Lampert, Patty Tuminello, Sarah Douglass, Jennifer Podegracz, Chris Stransky, Kyle Miller, Joel Guerrero, Brad Davidson, Ryan Halonen, Jon Groves, Robert Beltran, and Padrick Anderson, for their valuable contributions in the laboratory and/or field. NR 23 TC 8 Z9 8 U1 2 U2 32 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PD MAR PY 2012 VL 162 BP 449 EP 456 DI 10.1016/j.envpol.2011.11.018 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 903BB UT WOS:000301087800057 PM 22182967 ER PT J AU Rosen, G Chadwick, DB Burton, GA Taulbee, WK Greenberg, MS Lotufo, GR Reible, DD AF Rosen, Gunther Chadwick, D. Bart Burton, G. Allen Taulbee, W. Keith Greenberg, Marc S. Lotufo, Guilherme R. Reible, Danny D. TI A sediment ecotoxicity assessment platform for in situ measures of chemistry, bioaccumulation and toxicity. Part 2: Integrated application to a shallow estuary SO ENVIRONMENTAL POLLUTION LA English DT Article DE In situ; Toxicity; Passive samplers; Sediment; Weight-of-evidence ID POLYCYCLIC AROMATIC-HYDROCARBONS; SOLID-PHASE MICROEXTRACTION; COASTAL WATERS; BIOASSAYS; MARINE; BIOAVAILABILITY; CONTAMINANTS; POLLUTANTS; EXPOSURES; FIBERS AB A comprehensive, weight-of-evidence based ecological risk assessment approach integrating laboratory and in situ bioaccumulation and toxicity testing, passive sampler devices, hydrological characterization tools, continuous water quality sensing, and multi-phase chemical analyses was evaluated. The test site used to demonstrate the approach was a shallow estuarine wetland where groundwater seepage and elevated organic and inorganic contaminants were of potential concern. Although groundwater was discharging into the surficial sediments, little to no chemical contamination was associated with the infiltrating groundwater. Results from bulk chemistry analysis, toxicity testing, and bioaccumulation, however, suggested possible PAH toxicity at one station, which might have been enhanced by UV photoactivation, explaining the differences between in situ and laboratory amphipod survival. Concurrently deployed PAH bioaccumulation on solid-phase micro-extraction fibers positively correlated (r(2) >= 0.977) with in situ PAH bioaccumulation in amphipods, attesting to their utility as biomimetics, and contributing to the overall improved linkage between exposure and effects demonstrated by this approach. Published by Elsevier Ltd. C1 [Rosen, Gunther; Chadwick, D. Bart] Space & Naval Warfare Syst Ctr Pacific, San Diego, CA 92152 USA. [Burton, G. Allen; Taulbee, W. Keith] Univ Michigan, Ann Arbor, MI 48109 USA. [Greenberg, Marc S.] US EPA, Environm Response Team, Edison, NJ 08837 USA. [Lotufo, Guilherme R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Reible, Danny D.] Univ Texas Austin, Austin, TX 78712 USA. RP Rosen, G (reprint author), Space & Naval Warfare Syst Ctr Pacific, 53475 Strothe Rd, San Diego, CA 92152 USA. EM gunther.rosen@navy.mil; bart.chadwick@navy.mil; burtonal@umich.edu; ktaulbee@glec.com; greenberg.marc@epa.gov; guilherme.lotufo@usace.army.mil; reible@mail.utexas.edu RI Burton, Glenn/Q-9714-2016 OI Burton, Glenn/0000-0002-8660-6294 FU Strategic Environmental Research and Development Program [ER-1550]; Environmental Security Technology Certification Program [ER-0624] FX This research was funded by a grant from the Strategic Environmental Research and Development Program, under Project #ER-1550. The deployment of the SPME was supported by the Environmental Security Technology Certification Program, under Project #ER-0624. The authors thank David Lampert, Patty Tuminello, Sarah Douglass, Jennifer Podegracz, Kyle Miller, Joel Guerrero, Brad Davidson, Ryan Halonen, Jon Groves, Robert Beltran, Laura Palombi, and Padrick Anderson, for their valuable contributions in the laboratory and/or field. We gratefully acknowledge assistance from Mace Barron and Peggy Harris (EPA Gulf Ecology Division's Toxicology. Laboratory) for use of their facilities, and Mike Singletary and Patty Whittemore, who facilitated access to the site. NR 47 TC 8 Z9 8 U1 2 U2 44 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PD MAR PY 2012 VL 162 BP 457 EP 465 DI 10.1016/j.envpol.2011.11.013 PG 9 WC Environmental Sciences SC Environmental Sciences & Ecology GA 903BB UT WOS:000301087800058 PM 22172938 ER PT J AU Juliano, P Bilbao-Sainz, C Koutchma, T Balasubramaniam, VM Clark, S Stewart, CM Dunne, CP Barbosa-Canovas, GV AF Juliano, P. Bilbao-Sainz, C. Koutchma, T. Balasubramaniam, V. M. Clark, S. Stewart, Cindy M. Dunne, C. P. Barbosa-Canovas, G. V. TI Shelf-Stable Egg-Based Products Processed by High Pressure Thermal Sterilization SO FOOD ENGINEERING REVIEWS LA English DT Review DE High pressure; Processing; Sterilization; Egg; Egg product; Pasteurization; Shelf-stable; Commercialization ID INACTIVATION KINETICS; PACKAGING MATERIALS; WHOLE EGG; SPORES; FOOD; TEMPERATURES; PATTIES; QUALITY; MINCE AB Producing a thermally sterilized egg-based product with increased shelf life without losing the sensory and nutritional properties of the freshly prepared product is challenging. Until recently, all commercial shelf-stable egg-based products were sterilized using conventional thermal processing; however, this heat treatment was problematic as quality attributes of the product were negatively affected. Combining high pressure with high temperature is a potential alternative to retorting for the production of shelf-stable egg-based products. This review discusses the challenges of high pressure thermal sterilization as an alternative processing method of producing shelf-stable egg products. Attention is given to product improvement in terms of overall quality through modification of ingredients, formulation, processing and packaging, offering the industry a practical way to produce egg-based products with increased shelf life and appealing quality to the consumer. C1 [Juliano, P.] CSIRO Food & Nutr Sci, Werribee, Vic 3030, Australia. [Bilbao-Sainz, C.] ARS, USDA, Western Reg Res Ctr, Albany, CA 94710 USA. [Koutchma, T.] Agr & Agri Food Canada, Guelph Food Res Ctr, Guelph, ON N1G 5C9, Canada. [Balasubramaniam, V. M.] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA. [Clark, S.] Washington State Univ, Dept Food Sci & Human Nutr, Pullman, WA 99164 USA. [Stewart, Cindy M.] PepsiCo Adv Res, Hawthorne, NY 10532 USA. [Dunne, C. P.] USA, Res Dev & Engn Command, Natick, MA 01760 USA. [Barbosa-Canovas, G. V.] Washington State Univ, Dept Biol Syst Engn, Pullman, WA 99164 USA. RP Juliano, P (reprint author), CSIRO Food & Nutr Sci, Werribee, Vic 3030, Australia. EM pablo.juliano@csiro.au RI Juliano, Pablo/H-9251-2013; Balasubramaniam, VM Bala/A-2576-2008 OI Juliano, Pablo/0000-0002-7425-8085; Balasubramaniam, VM Bala/0000-0002-1540-4273 FU Defense Logistics, Agency Combat Rations Network, Natick Soldier Center FX Financial and technical support was provided by the Defense Logistics, Agency Combat Rations Network, Natick Soldier Center. The authors would like to acknowledge the National Center for Food Safety and Technology as one of the key contributing organizations in this project. The authors also thank Avure, Michael Foods Egg Products Company and ALCAN Packaging for their significant contribution to this project. The authors also thank Dr. Kai Knoerzer, Dr. Michelle Bull, and Dr. Roman Buckow for their contributions to this manuscript. NR 63 TC 6 Z9 6 U1 6 U2 42 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1866-7910 J9 FOOD ENG REV JI Food Eng. Rev. PD MAR PY 2012 VL 4 IS 1 BP 55 EP 67 DI 10.1007/s12393-011-9046-4 PG 13 WC Food Science & Technology SC Food Science & Technology GA 899XF UT WOS:000300849300003 ER PT J AU Lieberman, HR Kellogg, MD Kramer, FM Bathalon, GP Lesher, LL AF Lieberman, Harris R. Kellogg, Mark D. Kramer, F. Matthew Bathalon, Gaston P. Lesher, Larry L. TI Lipid and Other Plasma Markers Are Associated With Anxiety, Depression, and Fatigue SO HEALTH PSYCHOLOGY LA English DT Article DE biomarker; cholesterol; military; cognition; stress ID PLACEBO-CONTROLLED TRIAL; FREE FATTY-ACIDS; DOUBLE-BLIND; BODY-COMPOSITION; HYPOGLYCEMIA IMPAIRS; ENERGY-BALANCE; SUBSTANCE-P; SLEEP LOSS; MOOD; STRESS AB Objective: Few peripheral metabolites have been shown to be associated with mood in healthy individuals or patients with central nervous system diseases. During military basic combat training (BCT), mood state, physical performance and body composition substantially improve, providing an opportunity to examine relationships between mood and nutritional and hormonal biomarkers. Method: Thirty-five females enrolled in U.S. Marine BCT, an intense physically and mentally challenging 12-week course, were studied. Every 4 weeks, mood was assessed with the Profile of Mood States (POMS), as were nutritional, metabolic and hormonal plasma markers. Results: Mood and fitness improved over BCT, and there were substantial changes in biochemical markers. Multiple regression demonstrated that, in combination, cholesterol (HDL, LDL), fructosamine, triglycerides, free fatty acids (FFA), dehydroepiandrosterone-sulfate (DHEA-S), ACTH, and substance P accounted for 44% of variation in anxiety, 40% confusion, 37% fatigue, 27% depression and 40% in total mood (p < .0001). Increased HDL, FFA, DHEA-S, and substance P were associated with degraded mood (p < .05). Increased LDL, triglycerides, fructosamine, and ACTH were associated with improved mood (p < .05). Other markers, including glucose, cortisol, and C-reactive protein were not associated with mood. Conclusions: Normal human mood state was associated with 8 plasma markers. Increased HDL and lower LDL, which are associated with improved cardiovascular status, were associated with negative affect. Fructosamine and substance P, not previously known to be related to mood, were associated with it. We are not aware of any biological parameters that in aggregate predict such a substantial proportion of variation in normal mood. C1 [Lieberman, Harris R.; Bathalon, Gaston P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Kellogg, Mark D.] Childrens Hosp Boston, Dept Lab Med, Boston, MA USA. [Kellogg, Mark D.] Harvard Univ, Sch Med, Dept Pathol, Cambridge, MA 02138 USA. [Kramer, F. Matthew; Lesher, Larry L.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil OI Kellogg, Mark/0000-0003-1868-2153 FU U.S. Army Medical Research and Materiel Command FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or Department of Defense. Human subjects participated in these studies after giving their free and informed voluntary consent. The investigators have adhered to the policies for protection of human subjects as prescribed in Army Regulation 70-25, and the research was conducted in adherence with the provisions of 32 CFR Part 219. Citations of commercial organizations and trade names in this report do not constitute an official U.S. Department of the Army endorsement or approval of the products or services of these organizations. Supported by the U.S. Army Medical Research and Materiel Command. NR 53 TC 10 Z9 12 U1 0 U2 15 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0278-6133 J9 HEALTH PSYCHOL JI Health Psychol. PD MAR PY 2012 VL 31 IS 2 BP 210 EP 216 DI 10.1037/a0026499 PG 7 WC Psychology, Clinical; Psychology SC Psychology GA 907BM UT WOS:000301392800011 PM 22149131 ER PT J AU Chanthapan, S Kulkarni, A Singh, J Haines, C Kapoor, D AF Chanthapan, S. Kulkarni, A. Singh, J. Haines, C. Kapoor, D. TI Sintering of tungsten powder with and without tungsten carbide additive by field assisted sintering technology SO INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS LA English DT Article DE Field assisted sintering; Spark plasma sintering; Tungsten; Tungsten carbide; Grain growth ID GRAIN TUNGSTEN; YTTRIUM-OXIDE; FABRICATION AB Tungsten powder (0.6-0.9 mu m) was sintered by field assisted sintering technology (FAST) at various processing conditions. The sample sintered with in-situ hydrogen reduction pretreatment and pulsed electric current during heating showed the lowest amount of oxygen. The maximum relative density achieved was 98.5%, which is from the sample sintered at 2000 degrees C, 85 MPa for 30 min. However, the corresponding sintered grain size was 22.2 mu m. To minimize grain growth. nano tungsten carbide powder (0.1-0.2 mu m) was used as sintering additive. By mixing 5 and 10 vol.% WC with W powder, densification was enhanced and finer grain Size was obtained. Relative density above 99% with grain size around 3 tun was achieved in W-10 vol.% WC sintered at 1700 degrees C, 85 MPa, for 5 min. (C) 2011 Published by Elsevier Ltd. C1 [Singh, J.] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. [Chanthapan, S.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Kulkarni, A.] Penn State Univ, Dept Mech & Nucl Engn, University Pk, PA 16802 USA. [Haines, C.; Kapoor, D.] USA, ARDEC, Picatinny Arsenal, NJ USA. RP Singh, J (reprint author), Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. EM sxc448@psu.edu; akkme@engr.psu.edu; jxs46@arl.psu.edu; chris.haines@us.army.mil; deepak.kapoor@us.army.mil NR 14 TC 6 Z9 7 U1 2 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-4368 J9 INT J REFRACT MET H JI Int. J. Refract. Met. Hard Mat. PD MAR PY 2012 VL 31 BP 114 EP 120 DI 10.1016/j.ijrmhm.2011.09.014 PG 7 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 902GY UT WOS:000301027800017 ER PT J AU Zhou, SY Xi, JQ McDaniel, MW Nishihata, T Salesses, P Iagnemma, K AF Zhou, Shengyan Xi, Junqiang McDaniel, Matthew W. Nishihata, Takayuki Salesses, Phil Iagnemma, Karl TI Self-Supervised Learning to Visually Detect Terrain Surfaces for Autonomous Robots Operating in Forested Terrain SO JOURNAL OF FIELD ROBOTICS LA English DT Article ID CLASSIFICATION; NAVIGATION AB Autonomous robotic navigation in forested environments is difficult because of the highly variable appearance and geometric properties of the terrain. In most navigation systems, researchers assume a priori knowledge of the terrain appearance properties, geometric properties, or both. In forest environments, vegetation such as trees, shrubs, and bushes has appearance and geometric properties that vary with change of seasons, vegetation age, and vegetation species. In addition, in forested environments the terrain surface is often rough, sloped, and/or covered with a surface layer of grass, vegetation, or snow. The complexity of the forest environment presents difficult challenges for autonomous navigation systems. In this paper, a self-supervised sensing approach is introduced that attempts to robustly identify a drivable terrain surface for robots operating in forested terrain. The sensing system employs both LIDAR and vision sensor data. There are three main stages in the system: feature learning, feature training, and terrain prediction. In the feature learning stage, 3D range points from LIDAR are analyzed to obtain an estimate of the ground surface location. In the feature training stage, the ground surface estimate is used to train a visual classifier to discriminate between ground and nonground regions of the image. In the prediction stage, the ground surface location can be estimated at high frequency solely from vision sensor data. (C) 2012 Wiley Periodicals, Inc. C1 [Zhou, Shengyan; Xi, Junqiang] Beijing Inst Technol, Dept Mech Engn, Beijing 100081, Peoples R China. [McDaniel, Matthew W.; Nishihata, Takayuki; Iagnemma, Karl] MIT, Robot Mobil Grp, Cambridge, MA 02139 USA. [Salesses, Phil] USA, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Xi, JQ (reprint author), Beijing Inst Technol, Dept Mech Engn, Beijing 100081, Peoples R China. EM zhousy@mit.edu; xijunqiang@hotmail.com; mcdaniel@mit.edu; mark.p.salesses@us.army.mil; kdi@mit.edu OI Xi, Junqiang/0000-0001-8607-4542 FU U.S. Army Research Office [W912HZ-08-C-0060]; U.S. Army Topographic Engineering Center [W911NF-07-1-0540] FX This work was supported by the U.S. Army Research Office (Contract W912HZ-08-C-0060) and the U.S. Army Topographic Engineering Center (contract W911NF-07-1-0540). NR 25 TC 24 Z9 24 U1 0 U2 19 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1556-4959 J9 J FIELD ROBOT JI J. Field Robot. PD MAR-APR PY 2012 VL 29 IS 2 BP 277 EP 297 DI 10.1002/rob.21417 PG 21 WC Robotics SC Robotics GA 897QI UT WOS:000300668500004 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Undefeated: America's Heroic Fight for Bataan and Corregidor SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 1 PY 2012 VL 137 IS 4 BP 105 EP + PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 905WR UT WOS:000301307400146 ER PT J AU Mansi, IA Banks, DE AF Mansi, Ishak A. Banks, Daniel E. TI Evidence-Based Medicine for Clinicians SO SOUTHERN MEDICAL JOURNAL LA English DT Editorial Material C1 [Mansi, Ishak A.] Brooke Army Med Ctr, Internal Med Serv, San Antonio, TX 78234 USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ishak.mansi@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 109 EP 109 DI 10.1097/SMJ.0b013e31824b4726 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700003 PM 22392203 ER PT J AU Mansi, IA Banks, DE AF Mansi, Ishak A. Banks, Daniel E. TI The Challenge of Evidence-Based Medicine SO SOUTHERN MEDICAL JOURNAL LA English DT Editorial Material ID CONFLICT-OF-INTEREST; DECISION-MAKING; INFORMATION; STATISTICS; INDUSTRY; IMPACT; IMPLEMENTATION; LIBRARY; SERVICE; STAY C1 [Mansi, Ishak A.] Brooke Army Med Ctr, Internal Med Serv, San Antonio, TX 78234 USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ishak.mansi@us.army.mil NR 31 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 110 EP 113 DI 10.1097/SMJ.0b013e31824af18f PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700004 PM 22392204 ER PT J AU Morris, MJ Fewell, AE Oleszewski, RT AF Morris, Michael J. Fewell, Allyson E. Oleszewski, Ryan T. TI Evidence-Based Medicine: Specific Skills Necessary for Developing Expertise in Critical Appraisal SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE application; bias; critical appraisal; evidence-based medicine; question ID RANDOMIZED CONTROLLED-TRIALS; USERS GUIDES; HELP ME; PATIENT; WILL; PRINCIPLES; ARTICLE; TREAT; CARE AB The concept of evidence-based medicine (EBM), defined as the integration of best research evidence with clinical expertise and patient values, is essential to the review, understanding, and application of clinical principles into the practice of medicine. Critical appraisal includes recognizing and evaluating various study designs and their ranking in order of priority, judging relevance to the question at hand, identifying potential sources of bias, and determining whether the data presentation, statistical analysis, and conclusions are appropriate. The focus of this article is on the quality of the evidence and how each step in critical appraisal is important to the overall concept and application of EBM. C1 [Morris, Michael J.] Brooke Army Med Ctr, Dept Med, MCHE MDX, Ft Sam Houston, TX 78234 USA. Walter Reed Natl Mil Med Ctr, Dept Med, Washington, DC USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Dept Med, MCHE MDX, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM michael.morris@amedd.army.mil NR 23 TC 3 Z9 3 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 114 EP 119 DI 10.1097/SMJ.0b013e31824b197c PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700005 PM 22392205 ER PT J AU Mansi, IA AF Mansi, Ishak A. TI Statistics for the Nonstatistician: A Primer for Reading Clinical Studies SO SOUTHERN MEDICAL JOURNAL LA English DT Editorial Material ID PAPER C1 Brooke Army Med Ctr, Internal Med Serv, San Antonio, TX 78234 USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM Ishak.mansi@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 120 EP 125 DI 10.1097/SMJ.0b013e318246bab2 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700006 PM 22392206 ER PT J AU Wilton, NK Slim, AM AF Wilton, Nouansy K. Slim, Ahmad M. TI Application of the Principles of Evidence-Based Medicine to Patient Care SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE clinical practice; evidence-based medicine; PICO ID LENGTH-OF-STAY AB Evidence-based medicine (EBM) is the conscientious and judicious use of the best evidence available collected from clinical trials, guidelines, and consensus statements. This article provides simple ways to practice EBM using five steps (assess the patient, ask a clearly focused clinical question, acquire the best evidence available from the medical literature, appraise the evidence, and apply the evidence to patient care) and how to execute each step properly, multiple examples of how to apply EBM to patient care, and examples of how to apply the PICO mnemonic (patient, intervention, comparison, and outcome) to the process of EBM. C1 [Wilton, Nouansy K.] Brooke Army Med Ctr, Dept Med, IMC, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Cardiol, Ft Sam Houston, TX 78234 USA. RP Wilton, NK (reprint author), Brooke Army Med Ctr, Dept Med, IMC, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Nouansy.k.wilton@us.army.mil NR 20 TC 7 Z9 9 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 136 EP 143 DI 10.1097/SMJ.0b013e31824b464b PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700009 PM 22392209 ER PT J AU Timm, DF Banks, DE McLarty, J AF Timm, Donna F. Banks, Daniel E. McLarty, Jerry TI Critical Appraisal Process: Step-by-Step SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE computerized searching; evidence-based medicine ID EVIDENCE-BASED MEDICINE; PROSTATE-CANCER; QUALITY; TRIALS AB We present information describing how to search to identify those reports that provide insight into the answer to the query. We have presented a reasonable approach to searching, with our end-point being the identification of published articles which appear to answer our queries. The decision as to whether these articles are applicable to the patient under discussion is determined by our clinical knowledge and the specifics of the patient's medical concerns. This process is recognized as critical analysis. Our structure for optimal searching includes use of the PICO model, formulating a focused clinical question, and defining key search terms. Using these principles, we have addressed an example important controversy in the practice of clinical medicine; in other words, the effectiveness of screening for prostate cancer and whether it alters the natural history of this illness. C1 [Banks, Daniel E.] Brooke Army Med Ctr, Dept Med, San Antonio, TX 78234 USA. Louisiana State Univ, Dept Lib Sci & Med, Hlth Sci Ctr, Shreveport, LA 71105 USA. RP Banks, DE (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM dbanks3@LSUHSC.edu NR 16 TC 2 Z9 3 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 144 EP 148 DI 10.1097/SMJ.0b013e31824a711f PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700010 PM 22392210 ER PT J AU Berbano, EP Baxi, N AF Berbano, Elizabeth P. Baxi, Nancy TI Impact of Patient Selection in Various Study Designs: Identifying Potential Bias in Clinical Results SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE critical appraisal; evidence-based medicine; inclusion and exclusion criteria; randomized controlled trial; study design ID MEDICAL INTERVENTIONS; BENEFITS; JUPITER; THERAPY; HARMS; WOMEN; RISK AB Many different study designs are used to address different types of clinical questions. The two broad categories are the experimental study, which is the randomized controlled trial, and observational studies, which includes all of the other basic study designs (cohort [prospective and retrospective] studies, case-control [etiologic] studies, cross-sectional [prevalence] studies, case series, and case reports). These study designs address basic categories of clinical questions: treatment, diagnosis, prognosis, and harm. This article focuses on some of these study designs, highlighting the impact of patient selection, inclusion, and exclusion criteria on results and outcomes through the use of specific examples. C1 [Berbano, Elizabeth P.] Walter Reed Army Med Ctr, Dept Med, MCHL MG, Washington, DC 20307 USA. Louisiana State Univ, Sch Med, Dept Med, Shreveport, LA 71105 USA. RP Berbano, EP (reprint author), Walter Reed Army Med Ctr, Dept Med, MCHL MG, 6900 Georgia Ave, Washington, DC 20307 USA. EM elizabeth.berbano@amedd.army.mil NR 17 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 149 EP 155 DI 10.1097/SMJ.0b013e31824b4690 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700011 PM 22392211 ER PT J AU Furgerson, JL Hannah, WN Thompson, JC AF Furgerson, James L. Hannah, William N., Jr. Thompson, Jennifer C. TI Challenge of Surrogate Endpoints SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE biomarkers; clinical endpoint; intermediate endpoint; surrogate endpoint ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; HUMAN ATHEROSCLEROTIC LESIONS; RANDOMIZED CONTROLLED-TRIAL; ESTROGEN PLUS PROGESTIN; FOLIC-ACID; CARDIOVASCULAR-DISEASE; RISK-FACTOR; PLASMA HOMOCYSTEINE; VASCULAR-DISEASE AB Surrogate endpoints are biomarkers that are intended to substitute for clinical endpoints. They have been used to find novel therapeutic targets, improve the statistical power and shorten the duration of clinical trials, and control the cost of conducting research studies. The more generalized use of surrogate endpoints in clinical decision making can be hazardous and should be undertaken with great caution. This article reviews prior work with surrogate endpoints and highlights caveats and lessons learned from studies using surrogate endpoints. C1 [Furgerson, James L.; Hannah, William N., Jr.; Thompson, Jennifer C.] Brooke Army Med Ctr, MCHE MED Cardiol Serv, Dept Med, Ft Sam Houston, TX 78234 USA. RP Furgerson, JL (reprint author), Brooke Army Med Ctr, MCHE MED Cardiol Serv, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM james.furgerson@amedd.army.mil NR 44 TC 1 Z9 1 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 156 EP 160 DI 10.1097/SMJ.0b013e318249891e PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700012 PM 22392212 ER PT J AU Varma, J Rodriguez, R Mansi, IA AF Varma, Jai Rodriguez, Rechell Mansi, Ishak A. TI Reasoning and Evidence-Based Medicine: Common Pitfalls SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE evidence-based medicine; association; causation; extrapolation ID AMERICAN-DIABETES-ASSOCIATION; EXPERT CONSENSUS DOCUMENT; OF-CARDIOLOGY FOUNDATION; SCIENTIFIC STATEMENT; PRIMARY PREVENTION; HEART-ASSOCIATION; CARDIOVASCULAR EVENTS; POSITION STATEMENT; PEOPLE; OUTCOMES AB It is impossible to answer every potential clinical question through randomized controlled trials. Hence, assumptions, rational thinking, logic, and reasoning are used in making recommendations; however, these methods may interfere with the judicious application of evidence-based medicine and, as discussed in this article, may result in logical fallacies. We also explain how we may incorporate recommendations based on assumptions and rational thinking in patient care. Extrapolations of study content and confusing association with causation are common pitfalls in the application of the evidence-based medicine process. Personal bias can be another barrier in the adoption of evidence-based medicine. It can be difficult to modify personal bias despite the evidence; keeping up with the medical literature in a busy practice can be daunting. C1 [Mansi, Ishak A.] Brooke Army Med Ctr, Internal Med Serv, San Antonio, TX 78234 USA. Louisiana State Univ, Hlth Sci Ctr, Wilford Hall Med Ctr, Sch Med, San Antonio, TX USA. RP Mansi, IA (reprint author), Brooke Army Med Ctr, Internal Med Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM ishak.mansi@us.army.mil NR 26 TC 2 Z9 2 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 167 EP 172 DI 10.1097/SMJ.0b013e31824ab448 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700014 PM 22392214 ER PT J AU Mansi, IA Thompson, JC Banks, DE AF Mansi, Ishak A. Thompson, Jennifer C. Banks, Daniel E. TI Final Tips in Interpreting Evidence-Based Medicine SO SOUTHERN MEDICAL JOURNAL LA English DT Review DE evidence-based medicine; interpretation; medical education ID PERCUTANEOUS CORONARY INTERVENTION; AMERICAN-DIABETES-ASSOCIATION; CLINICAL-TRIALS; STATISTICAL SIGNIFICANCE; CARDIOVASCULAR-DISEASES; MYOCARDIAL-INFARCTION; SCIENTIFIC STATEMENT; PRIMARY PREVENTION; HEART-ASSOCIATION; EVENTS AB In this issue, the Southern Medical Journal presents a series of articles to help students of medicine understand the principles of evidence-based medicine. These articles are not meant to be a comprehensive review, but rather an easy-to-read primer. In this final article, the authors offer suggestions to aid the reader in navigating the ever-expanding amount of information. These tips address a number of points that are commonly encountered in the medical literature, but are not all-inclusive. C1 Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Banks, DE (reprint author), Louisiana State Univ, Sch Med, Dept Med, 1501 Kings Hwy, Shreveport, LA 71103 USA. EM dbanks49@yahoo.com NR 43 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD MAR PY 2012 VL 105 IS 3 SI SI BP 173 EP 180 DI 10.1097/SMJ.0b013e318249c152 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 905OA UT WOS:000301280700015 PM 22392215 ER PT J AU Detweiler, MB Arif, S Candelario, J Altman, J Murphy, PF Halling, MH Vasudeva, S Detweiler, JG AF Detweiler, Mark B. Arif, Saira Candelario, Joseph Altman, Joanne Murphy, Pamela F. Halling, Mary H. Vasudeva, Sachinder Detweiler, Jonna G. TI Salem VAMC-US Army Fort Bragg Warrior Transition Clinic Telepsychiatry Collaboration: 12-Month Operation Clinical Perspective SO TELEMEDICINE AND E-HEALTH LA English DT Article DE telepsychiatry; military medicine; telehealth ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; PSYCHIATRIC-DISORDERS; SECONDARY TRAUMATIZATION; SUBSTANCE-ABUSE; DEPRESSION; VETERANS; PTSD; SOLDIERS; PREVALENCE AB Objective: To describe the clinical experience in the first Veterans Affairs (VA)-U. S. Army Warrior Transition Clinic (WTC) telepsychiatry operation (September 2008-August 2009). Materials: Joint VA and U.S. Army records. Methods: Analysis of intake, follow-up, and last visit records. Results: One hundred twenty active-duty U.S. Army soldiers were seen (394 clinic visits). Ninety-eight soldiers had one or more combat tours, principally in Iraq and Afghanistan. Posttraumatic stress disorder was diagnosed in 50.0% of the cases by the WTC telepsychiatrists. The majority of the soldiers had medical comorbidities, especially chronic pain (75.0%), in addition to mental health problems. Several of the soldiers were recovering from trauma (20.8%) and/or surgery (23.3%), 11.7% exhibited traumatic brain injuries, and 17.5% had headaches. Disrupted relationships (74.2%) were notable for non-family members, especially military cohorts such as other persons in the same WTC squad or platoon. Conclusion: The observations in this report come from a cross-section of soldiers who were triaged to meet WTC admission criteria. As this is the prototype VA-U.S. Army telepsychiatry collaboration, there are no comparative data at this time. The nature of the medical and psychiatric problems treated in the military WTC represents an index of the more severe combat trauma treated on military bases from ongoing combat operations and may predict future VA-U. S. Army collaborative telepsychiatry clinic experiences. C1 [Detweiler, Mark B.; Murphy, Pamela F.; Halling, Mary H.; Detweiler, Jonna G.] Salem VAMC, Geriatr Res Grp, Salem, VA USA. [Arif, Saira] Univ Virginia Roanoke, Caril Clin, Salem Psychiat Med Residency Program, Salem, VA USA. [Candelario, Joseph] Salem VAMC, Emergency Dept, Salem, VA USA. [Altman, Joanne] USA, Warrior Transit Clin, Ft Bragg, NC USA. [Murphy, Pamela F.] Virginia Tech, Adjunct Fac, Blacksburg, VA USA. RP Detweiler, MB (reprint author), Vet Affairs Med Ctr, 1970 Roanoke Blvd, Salem, VA 24153 USA. EM mark.detweiler1@va.gov NR 53 TC 4 Z9 4 U1 3 U2 5 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED E-HEALTH JI Telemed. e-Health PD MAR PY 2012 VL 18 IS 2 BP 81 EP 86 DI 10.1089/tmj.2011.0064 PG 6 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 902MB UT WOS:000301041200002 PM 22283361 ER PT J AU Berglund, RK Tangen, CM Powell, IJ Lowe, BA Haas, GP Carroll, PR Canby-Hagino, ED White, RD Hemstreet, GP Crawford, D Thompson, IM Klein, EA AF Berglund, Ryan K. Tangen, Catherine M. Powell, Isaac J. Lowe, Bruce A. Haas, Gabriel P. Carroll, Peter R. Canby-Hagino, Edith D. White, Ralph deVere Hemstreet, George P., III Crawford, David Thompson, Ian M., Jr. Klein, Eric A. TI Ten-year Follow-up of Neoadjuvant Therapy with Goserelin Acetate and Flutamide Before Radical Prostatectomy for Clinical T3 and T4 Prostate Cancer: Update on Southwest Oncology Group Study 9109 SO UROLOGY LA English DT Article ID HIGH-RISK; TRIAL; RADIOTHERAPY; IRRADIATION; OUTCOMES; STAGE; EORTC AB OBJECTIVE To update the results with 10-year data of a phase II prospective trial of neoadjuvant hormonal therapy with goserelin acetate and flutamide followed by radical prostatectomy for locally advanced prostate cancer (SWOG 9109). The optimal management for clinical stage T3 and T4 N0,M0 prostate cancer is uncertain. MATERIALS AND METHODS Sixty-two patients with clinical stage T3 and T4 N0, M0 prostate cancer were enrolled. Cases were classified by stage T3 vs T4 and by volume of disease (bulky >4 cm and nonbulky <= 4 cm). RESULTS Fifty-five of 61 eligible patients completed the trial with radical prostatectomy after neoadjuvant androgen deprivation therapy (ADT). The median preoperative prostate-specific antigen value was 19.8 ng/mL, and 67% of patients had a Gleason score of >= 7. Among 41 patients last known to be alive, median follow-up is 10.6 years (range 5.1-12.6). In all, 38 patients have had disease progression (30/55, 55%) or died without progression (8/55, 15%) for a 10-year progression-free survival (PFS) estimate of 40% (95% CI 27-53). Median PFS was 7.5 years, and median survival has not been reached. The 10-year overall survival (OS) estimate is 68% (95% CI 56-80). CONCLUSIONS In this small, prospective phase II study, neoadjuvant hormonal therapy with goserelin acetate and flutamide followed by radical prostatectomy achieves long-term PFS and OS comparable with alternative treatments. This approach is feasible and may be an alternative to a strategy of combined radiation and ADT. UROLOGY 79: 633-637, 2012. (C) 2012 Elsevier Inc. All rights reserved. C1 Cleveland Clin Fdn, Dept Urol, Cleveland, OH 44195 USA. SW Oncol Grp, Ctr Stat, Seattle, WA USA. Wayne State Univ, Med Ctr, Detroit, MI 48202 USA. NW Urol Clin, Portland, OR USA. SUNY Syracuse, Syracuse, NY USA. Univ Calif San Francisco, San Francisco, CA 94143 USA. Wilford Hall USAF Med Ctr, Brooke Army Med Ctr, Lackland AFB, TX USA. Univ Calif Davis, Sacramento, CA 95817 USA. Univ Nebraska Med Ctr, Omaha, NE USA. Univ Colorado, Denver, CO 80202 USA. Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Berglund, RK (reprint author), Cleveland Clin, Dept Urol, 9500 Euclid Blvd,Q10-1, Cleveland, OH 44195 USA. EM berglur@ccf.org FU National Cancer Institute, DHHS [CA32102, CA38926, CA22433, CA14028, CA76447, CA46441, CA42777, CA35178, CA46113, CA58658, CA20319, CA76132, CA04919, CA35176, CA16385, CA35090, CA13612, CA58348] FX This investigation was supported in part by the following PHS Cooperative Agreement grant numbers awarded by the National Cancer Institute, DHHS: CA32102, CA38926, CA22433, CA14028, CA76447, CA46441, CA42777, CA35178, CA46113, CA58658, CA20319, CA76132, CA04919, CA35176, CA16385, CA35090, CA13612, CA04919 and CA58348. NR 15 TC 10 Z9 10 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD MAR PY 2012 VL 79 IS 3 BP 633 EP 637 DI 10.1016/j.urology.2011.11.019 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA 903XB UT WOS:000301154400044 PM 22386416 ER PT J AU Cardozo, ER Clark, AD Banks, NK Henne, MB Stegmann, BJ Segars, JH AF Cardozo, Eden R. Clark, Andrew D. Banks, Nicole K. Henne, Melinda B. Stegmann, Barbara J. Segars, James H. TI The estimated annual cost of uterine leiomyomata in the United States SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE cost; fibroid tumor; uterine leiomyomata ID HYSTERECTOMY RATES; PREGNANCY; FIBROIDS; WOMEN; COMPLICATIONS; INFERTILITY; POPULATION; MANAGEMENT; TRIMESTER; DELIVERY AB OBJECTIVE: The purpose of this study was to estimate the total annual societal cost of uterine fibroid tumors in the United States, based on direct and indirect costs that include associated obstetric complications. STUDY DESIGN: A systematic review of the literature was conducted to estimate the number of women who seek treatment for symptomatic fibroid tumors annually, the costs of medical and surgical treatment, the amount of work time lost, and obstetric complications that are attributable to fibroid tumors. Total annual costs were converted to 2010 US dollars. A sensitivity analysis was performed. RESULTS: The estimated annual direct costs (surgery, hospital admissions, outpatient visits, and medications) were $ 4.1-9.4 billion. Estimated lost work-hour costs ranged from $ 1.55-17.2 billion annually. Obstetric outcomes that were attributed to fibroid tumors resulted in a cost of $ 238 million to $ 7.76 billion annually. Uterine fibroid tumors were estimated to cost the United States $ 5.9-34.4 billion annually. CONCLUSION: Obstetric complications that are associated with fibroid tumors contributed significantly to their economic burden. Lost work-hour costs may account for the largest proportion of societal costs because of fibroid tumors. C1 [Cardozo, Eden R.] Northwestern Univ, Dept Obstet & Gynecol, Feinberg Sch Med, Chicago, IL 60611 USA. [Clark, Andrew D.] Univ S Carolina, Sch Med, Greenville Hosp Syst Campus, Dept Obstet & Gynecol, Greenville, SC USA. [Banks, Nicole K.] NHGRI, NIH, Bethesda, MD 20892 USA. [Segars, James H.] Eunice Kennedy Shriver Natl Inst Child & Human De, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA. [Henne, Melinda B.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol, Washington, DC 20307 USA. [Stegmann, Barbara J.] Univ Iowa Hosp & Clin, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Iowa City, IA 52242 USA. RP Segars, JH (reprint author), Bldg 10,CRC,Room 1E-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM segarsj@mail.nih.gov FU National Institute of Child Health and Human Development, National Institutes of Health; National Institutes of Health FX This study was supported, in part, by the Intramural Research Program of Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health.; We acknowledge the support and advice of Drs Alan H. DeCherney and Vivian Pinn (National Institutes of Health Intramural Funding; no compensation relative to the publication). The authors appreciated the suggestions and comments of Dr Alicia Armstrong (National Institutes of Health Intramural Funding; no compensation relative to the publication) and the technical expertise and assistance provided by Miriam Levy (PIRA Energy Group; no compensation relative to this publication). NR 39 TC 32 Z9 33 U1 0 U2 7 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD MAR PY 2012 VL 206 IS 3 AR 211.e1 DI 10.1016/j.ajog.2011.12.002 PG 9 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 900HW UT WOS:000300878600021 PM 22244472 ER PT J AU Louie, A VanScoy, BD Brown, DL Kulawy, RW Heine, HS Drusano, GL AF Louie, Arnold VanScoy, Brian D. Brown, David L. Kulawy, Robert W. Heine, Henry S. Drusano, George L. TI Impact of Spores on the Comparative Efficacies of Five Antibiotics for Treatment of Bacillus anthracis in an In Vitro Hollow Fiber Pharmacodynamic Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID RESISTANT STAPHYLOCOCCUS-AUREUS; POSTEXPOSURE PROPHYLAXIS; TOXIN PRODUCTION; INHALATIONAL ANTHRAX; CLINDAMYCIN; GERMINATION; THERAPY; CIPROFLOXACIN; LEVOFLOXACIN; DOXYCYCLINE AB Bacillus anthracis, the bacterium that causes anthrax, is an agent of bioterrorism. The most effective antimicrobial therapy for B. anthracis infections is unknown. An in vitro pharmacodynamic model of B. anthracis was used to compare the efficacies of simulated clinically prescribed regimens of moxifloxacin, linezolid, and meropenem with the "gold standards," doxycycline and ciprofloxacin. Treatment outcomes for isogenic spore-forming and non-spore-forming strains of B. anthracis were compared. Against spore-forming B. anthracis, ciprofloxacin, moxifloxacin, linezolid, and meropenem reduced the B. anthracis population by 4 log(10) CFU/ml over 10 days. Doxycycline reduced the population of this B. anthracis strain by 5 log(10) CFU/ml (analysis of variance [ANOVA] P = 0.01 versus other drugs). Against an isogenic non-spore-forming strain, meropenem killed the vegetative B. anthracis the fastest, followed by moxifloxacin and ciprofloxacin and then doxycycline. Linezolid offered the lowest bacterial kill rate. Heat shock studies using the spore-producing B. anthracis strain showed that with moxifloxacin, ciprofloxacin, and meropenem therapies the total population was mostly spores, while the population was primarily vegetative bacteria with linezolid and doxycycline therapies. Spores have a profound impact on the rate and extent of killing of B. anthracis. Against spore-forming B. anthracis, the five antibiotics killed the total (spore and vegetative) bacterial population at similar rates (within 1 log(10) CFU/ml of each other). However, bactericidal antibiotics killed vegetative B. anthracis faster than bacteriostatic drugs. Since only vegetative-phase B. anthracis produces the toxins that may kill the infected host, the rate and mechanism of killing of an antibiotic may determine its overall in vivo efficacy. Further studies are needed to examine this important observation. C1 [Louie, Arnold; VanScoy, Brian D.; Brown, David L.; Kulawy, Robert W.; Drusano, George L.] Ctr Biodef & Emerging Infect, Ordway Res Inst, Albany, NY USA. [Heine, Henry S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Louie, A (reprint author), Univ Florida, Coll Med, Albany Campus, Albany, NY 12208 USA. EM arnold.louie@medicine.ufl.edu FU National Institutes of Allergy and Infectious Diseases [P01AI060908] FX This work was supported by grant number P01AI060908 from the National Institutes of Allergy and Infectious Diseases. NR 44 TC 7 Z9 8 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAR PY 2012 VL 56 IS 3 BP 1229 EP 1239 DI 10.1128/AAC.01109-10 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 897DN UT WOS:000300623300011 PM 22155821 ER PT J AU Mina, R von Scheven, E Ardoin, SP Eberhard, BA Punaro, M Ilowite, N Hsu, J Klein-Gitelman, M Moorthy, LN Muscal, E Radhakrishna, SM Wagner-Weiner, L Adams, M Blier, P Buckley, L Chalom, E Chedeville, G Eichenfield, A Fish, N Henrickson, M Hersh, AO Hollister, R Jones, O Jung, L Levy, D Lopez-Benitez, J McCurdy, D Miettunen, PM Quintero-Del Rio, AI Rothman, D Rullo, O Ruth, N Schanberg, LE Silverman, E Singer, NG Soep, J Syed, R Vogler, LB Yalcindag, A Yildirim-Toruner, C Wallace, CA Brunner, HI AF Mina, Rina von Scheven, Emily Ardoin, Stacy P. Eberhard, B. Anne Punaro, Marilynn Ilowite, Norman Hsu, Joyce Klein-Gitelman, Marisa Moorthy, L. Nandini Muscal, Eyal Radhakrishna, Suhas M. Wagner-Weiner, Linda Adams, Matthew Blier, Peter Buckley, Lenore Chalom, Elizabeth Chedeville, Gaelle Eichenfield, Andrew Fish, Natalya Henrickson, Michael Hersh, Aimee O. Hollister, Roger Jones, Olcay Jung, Lawrence Levy, Deborah Lopez-Benitez, Jorge McCurdy, Deborah Miettunen, Paivi M. Quintero-Del Rio, Ana I. Rothman, Deborah Rullo, Ornella Ruth, Natasha Schanberg, Laura E. Silverman, Earl Singer, Nora G. Soep, Jennifer Syed, Reema Vogler, Larry B. Yalcindag, Ali Yildirim-Toruner, Cagri Wallace, Carol A. Brunner, Hermine I. CA CARRA SLE Subcomm TI Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus SO ARTHRITIS CARE & RESEARCH LA English DT Article ID QUALITY-OF-LIFE; MYCOPHENOLATE-MOFETIL TREATMENT; INTRAVENOUS CYCLOPHOSPHAMIDE; IDIOPATHIC ARTHRITIS; PRELIMINARY CRITERIA; CONTROLLED-TRIAL; RENAL-DISEASE; CHILDREN; CLASSIFICATION; GLOMERULONEPHRITIS AB Objective To formulate consensus treatment plans (CTPs) for induction therapy of newly diagnosed proliferative lupus nephritis (LN) in juvenile systemic lupus erythematosus (SLE). Methods. A structured consensus formation process was employed by the members of the Childhood Arthritis and Rheumatology Research Alliance after considering the existing medical evidence and current treatment approaches. Results. After an initial Delphi survey ( response rate = 70%), a 2-day consensus conference, and 2 followup Delphi surveys ( response rates = 63-79%), consensus was achieved for a limited set of CTPs addressing the induction therapy of proliferative LN. These CTPs were developed for prototypical patients defined by eligibility characteristics, and included immunosuppressive therapy with either mycophenolic acid orally twice per day, or intravenous cyclophosphamide once per month at standardized dosages for 6 months. Additionally, the CTPs describe 3 options for standardized use of glucocorticoids, including a primarily oral, a mixed oral/intravenous, and a primarily intravenous regimen. There was consensus on measures of effectiveness and safety of the CTPs. The CTPs were well accepted by the pediatric rheumatology providers treating children with LN, and up to 300 children per year in North America are expected to be candidates for the treatment with the CTPs. Conclusion. CTPs for induction therapy of proliferative LN in juvenile SLE based on the available scientific evidence and pediatric rheumatology group experience have been developed. Consistent use of the CTPs may improve the prognosis of proliferative LN, and support the conduct of comparative effectiveness studies aimed at optimizing therapeutic strategies for proliferative LN in juvenile SLE. C1 [von Scheven, Emily] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Mina, Rina; Henrickson, Michael; Brunner, Hermine I.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA. [Ardoin, Stacy P.] Ohio State Univ, Columbus, OH 43210 USA. [Ardoin, Stacy P.] Nationwide Childrens Hosp, Columbus, OH USA. [Eberhard, B. Anne] Steven & Alexandra Cohen Childrens Med Ctr New Yo, New York, NY USA. [Punaro, Marilynn] Texas Scottish Rite Hosp Crippled Children, Dallas, TX USA. [Ilowite, Norman] Childrens Hosp Montefiore, Albert Einstein Coll Med, Bronx, NY USA. [Hsu, Joyce] Lucile Packard Childrens Hosp Stanford, Palo Alto, CA USA. [Klein-Gitelman, Marisa] Childrens Mem Hosp, Chicago, IL 60614 USA. [Moorthy, L. Nandini] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, New Brunswick, NJ USA. [Muscal, Eyal] Texas Childrens Hosp, Baylor Coll Med, Pediat Rheumatol Ctr, Houston, TX 77030 USA. [Radhakrishna, Suhas M.] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA. [Wagner-Weiner, Linda] Univ Chicago, Comer Childrens Hosp, Chicago, IL 60637 USA. [Adams, Matthew] Childrens Hosp Michigan, Detroit, MI 48201 USA. [Blier, Peter] Baystate Childrens Hosp, Springfield, MA USA. [Buckley, Lenore] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23284 USA. [Chalom, Elizabeth] St Barnabas Hosp, Livingston, NJ USA. [Chedeville, Gaelle] McGill Univ, Montreal Childrens Hosp, Ctr Hlth, Montreal, PQ H3H 1P3, Canada. [Eichenfield, Andrew; Yildirim-Toruner, Cagri] Morgan Stanley Childrens Hosp New York Presbyteri, New York, NY USA. [Eichenfield, Andrew; Yildirim-Toruner, Cagri] Columbia Univ, Med Ctr, New York, NY USA. [Fish, Natalya] Penn State Hershey Childrens Hosp, Hershey, PA USA. [Hersh, Aimee O.] Univ Utah, Salt Lake City, UT USA. [Hollister, Roger; Soep, Jennifer] Childrens Hosp Colorado, Aurora, CO USA. [Jones, Olcay] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Jung, Lawrence] Childrens Natl Med Ctr, Washington, DC 20010 USA. [Levy, Deborah; Silverman, Earl] Hosp Sick Children, Toronto, ON M5G 1X8, Canada. [Lopez-Benitez, Jorge] Tufts Med Ctr, Floating Hosp Children, Boston, MA USA. [McCurdy, Deborah; Rullo, Ornella] Univ Calif Los Angeles, Mattel Childrens Hosp, Los Angeles, CA USA. [Miettunen, Paivi M.] Univ Calgary, Calgary, AB, Canada. [Quintero-Del Rio, Ana I.] Univ Cent Caribe, Bayamon, PR USA. [Rothman, Deborah] Shriners Hosp Children, Springfield, MA USA. [Ruth, Natasha] Med Univ S Carolina, Charleston, SC USA. [Schanberg, Laura E.] Duke Univ, Med Ctr, Durham, NC USA. [Singer, Nora G.] Case Western Reserve Univ, Sch Med, Metrohlth Med Ctr, Cleveland, OH USA. [Syed, Reema] St Louis Univ, St Louis, MO 63103 USA. [Vogler, Larry B.] Emory Childrens Ctr, Atlanta, GA USA. [Yalcindag, Ali] Hasbro Childrens Hosp, Providence, RI USA. [Wallace, Carol A.] Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USA. RP von Scheven, E (reprint author), Univ Calif San Francisco, Box 0107,505 Parnassus Ave,Room M-679, San Francisco, CA 94143 USA. EM evonsche@peds.ucsf.edu OI Ilowite, Norman/0000-0002-8298-8563; Singer, Nora/0000-0001-7041-723X FU NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases [C1AR058605-01, R13-AR053058-04]; Childhood Arthritis and Rheumatology Research Alliance; Arthritis Foundation; Wasie Foundation; Friends of the Childhood Arthritis and Rheumatology Research Alliance; National Institute of Arthritis and Musculoskeletal and Skin Diseases [K23AR053202, NO1-AR-2-2265, RC2-AR-058934, 1U01AR059509, U01AR055054, P60 AR47784]; Johnson Johnson FX Supported by the NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants C1AR058605-01 and R13-AR053058-04), the Childhood Arthritis and Rheumatology Research Alliance, the Arthritis Foundation, the Wasie Foundation, and the Friends of the Childhood Arthritis and Rheumatology Research Alliance. Dr. Mina's work was supported by a National Institute of Arthritis and Musculoskeletal and Skin Diseases T32 training grant. Dr. Levy's work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant K23AR053202). Dr. Schanberg's work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants NO1-AR-2-2265 and RC2-AR-058934). Dr. Brunner's work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants 1U01AR059509, U01AR055054, and P60 AR47784).; Dr. Ardoin has received consultant fees, speaking fees, and/or honoraria (less than $ 10,000) from Johnson & Johnson. NR 44 TC 42 Z9 44 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 2151-464X J9 ARTHRIT CARE RES JI Arthritis Care Res. PD MAR PY 2012 VL 64 IS 3 BP 375 EP 383 DI 10.1002/acr.21558 PG 9 WC Rheumatology SC Rheumatology GA 899QP UT WOS:000300831500009 PM 22162255 ER PT J AU Stark, TD Beaty, MH Byrne, PM Castro, G Walberg, FC Perlea, VG Axtell, PJ Dillon, JC Empson, WB Mathews, DL AF Stark, Timothy D. Beaty, Michael H. Byrne, Peter M. Castro, Gonzalo Walberg, Francke C. Perlea, Vlad G. Axtell, Paul J. Dillon, John C. Empson, William B. Mathews, David L. TI Seismic deformation analysis of Tuttle Creek Dam SO CANADIAN GEOTECHNICAL JOURNAL LA English DT Article DE earthquakes; liquefaction; numerical analysis; shear strength; post-liquefaction; slope stability ID WATER FILM; LIQUEFACTION; STRENGTH; SAND AB To facilitate the design of seismic remediation for Tuttle Creek Dam in east central Kansas, a seismic finite difference analysis of the dam was performed using the software FLAC and the UBCSAND and UBCTOT soil constitutive models. The FLAC software has a key advantage because it can use calibrated site-specific constitutive models. Earlier deformation analyses using a hyperbolic constitutive model for the foundation fine-grained materials did not properly represent the modulus and strength reduction and predicted extremely large permanent deformations. Cyclic triaxial laboratory tests using high-quality samples and in situ vane shear tests were used to calibrate the FLAC constitutive model herein. The resulting FLAC analysis of the unremediated dam predicted an upstream slope toe deformation of about 0.6 m, a crest settlement of about 0.6 m, and a downstream slope toe deformation of about 1.5 m using the design ground motion. Based on the estimated permanent deformations and other factors, it was decided that the anticipated upstream slope and crest deformations were tolerable and only the downstream slope had to be remediated to protect the downstream seepage control system. C1 [Stark, Timothy D.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. [Beaty, Michael H.] Beaty Engn LLC, Beaverton, OR USA. [Byrne, Peter M.] Univ British Columbia, Dept Civil Engn, Vancouver, BC, Canada. [Castro, Gonzalo] GEI Consultants Inc, Winchester, MA USA. [Walberg, Francke C.] URS Corp, Overland Pk, KS USA. [Perlea, Vlad G.] USA, Corps Engineers, Sacramento, CA USA. [Axtell, Paul J.] Dan Brown & Associates, Kansas City, MO USA. [Dillon, John C.; Empson, William B.; Mathews, David L.] USA, Corps Engineers, Kansas City, MO USA. RP Stark, TD (reprint author), Univ Illinois, Dept Civil & Environm Engn, 205 N Mathews Ave, Urbana, IL 61801 USA. EM tstark@illinois.edu NR 43 TC 4 Z9 4 U1 1 U2 8 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0008-3674 J9 CAN GEOTECH J JI Can. Geotech. J. PD MAR PY 2012 VL 49 IS 3 BP 323 EP 343 DI 10.1139/T11-107 PG 21 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 900RD UT WOS:000300905300006 ER PT J AU Zurawski, DV Thompson, MG McQueary, CN Matalka, MN Sahl, JW Craft, DW Rasko, DA AF Zurawski, Daniel V. Thompson, Mitchell G. McQueary, Christin N. Matalka, Malcolm N. Sahl, Jason W. Craft, David W. Rasko, David A. TI Genome Sequences of Four Divergent Multidrug-Resistant Acinetobacter baumannii Strains Isolated from Patients with Sepsis or Osteomyelitis SO JOURNAL OF BACTERIOLOGY LA English DT Article ID OUTBREAK AB Acinetobacter baumannii is a Gram-negative bacterium that causes nosocomial infections worldwide, with recent prevalence and higher frequency in wounded military personnel. Four A. baumannii strains from the Walter Reed Army Medical Center (WRAMC) isolated between 2008 and 2009 were sequenced, representing diverse, multidrug-resistant isolates from osteomyelitis or septic patients. C1 [Zurawski, Daniel V.; Thompson, Mitchell G.; McQueary, Christin N.; Craft, David W.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. [Matalka, Malcolm N.; Sahl, Jason W.; Rasko, David A.] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA. RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD USA. EM daniel.zurawski@amedd.army.mil RI Zurawski, Daniel/B-6578-2009; OI Zurawski, Daniel/0000-0002-7920-5601; David, Rasko/0000-0002-7337-7154 FU AvidBiotics Inc.; NIH [R43 AI088863-01] FX We thank AvidBiotics Inc. and, specifically, David Martin and Dean Scholl for their support with our A. baumannii research.; We acknowledge the NIH grant R43 AI088863-01 for the funding required for this project. NR 14 TC 18 Z9 18 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD MAR PY 2012 VL 194 IS 6 BP 1619 EP 1620 DI 10.1128/JB.06749-11 PG 2 WC Microbiology SC Microbiology GA 899WI UT WOS:000300846900041 PM 22374953 ER PT J AU Gupta, N Voloshinov, VB Knyazev, GA Kulakova, LA AF Gupta, N. Voloshinov, V. B. Knyazev, G. A. Kulakova, L. A. TI Tunable wide-angle acousto-optic filter in single-crystal tellurium SO JOURNAL OF OPTICS LA English DT Article DE acousto-optic tunable filter; AOTF; tellurium; long-wave infrared; LWIR; optical transmission; spectral resolution; tuning curve; spectral images ID 10.6 MU-M; PERFORMANCE; HG2CL2 AB The acoustic, optic and acousto-optic properties of tellurium crystals have been examined in order to develop an acousto-optic tunable filter (AOTF) operating in the long-wave infrared (LWIR) region. The AOTF design is based on the wide-angle regime of light diffraction in the YZ plane of the birefringent crystal operating from 8.4 to 13.6 mu m. Device characteristics were obtained from both theoretical and experimental investigations. Experiments were carried out using both a 10.6 mu m pulsed CO2 laser as well as a tunable CO2 laser operating in a continuous wave mode from 9.2 to 10.7 mu m. The AOTF was tuned over the acoustic frequency range of 81.5-94.7 MHz. The filtering performance in the tellurium device was provided by a pure shear elastic wave propagating at a 95.8 degrees angle with respect to the positive direction of the optic axis, while an ordinary polarized optical beam was incident at the Bragg angle of 6.0 degrees relative to the acoustic wavefront. At 10.6 mu m, the measured spectral bandwidth of the filter was 127 nm and the optical transmission coefficient was around 8.8% with 2.0 W drive power. This paper presents detailed results from both the theoretical as well as experimental device characterization including the spectral images obtained with a 256 x 256 mercury cadmium telluride camera cooled to 77 K. C1 [Gupta, N.] USA, Res Lab, Adelphi, MD 20783 USA. [Voloshinov, V. B.; Knyazev, G. A.] Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia. [Kulakova, L. A.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM neelam.gupta.civ@mail.mil; volosh@phys.msu.ru; L.Kulakova@mail.ioffe.ru RI Voloshinov, Vitaly/I-6045-2012; Gupta, Neelam/B-8702-2013 FU US Civilian Research and Development Foundation [RUP1-1663-MO-06]; Russian Fund for Basic Research RFBR [10-07-00623, 10-07-00683] FX Research of the Russian team was supported by the grant RUP1-1663-MO-06 of the US Civilian Research and Development Foundation and the grants of the Russian Fund for Basic Research RFBR 10-07-00623 and 10-07-00683. NR 32 TC 20 Z9 20 U1 0 U2 16 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 2040-8978 J9 J OPTICS-UK JI J. Opt. PD MAR PY 2012 VL 14 IS 3 AR 035502 DI 10.1088/2040-8978/14/3/035502 PG 9 WC Optics SC Optics GA 899BS UT WOS:000300788400010 ER PT J AU McCarron, M Azimi-Sadjadi, MR Mungiole, M AF McCarron, Michael Azimi-Sadjadi, Mahmood R. Mungiole, Michael TI An operationally adaptive system for rapid acoustic transmission loss prediction SO NEURAL NETWORKS LA English DT Article DE Acoustic propagation; Feedforward neural network; Fusion method ID RANGE SOUND-PROPAGATION; ATMOSPHERE; TUTORIAL; MODELS AB An operationally adaptive (OA) system for prediction of acoustic transmission loss (TL) in the atmosphere is developed in this paper. This system uses expert neural network predictors, each corresponding to a specific range of source elevation. The outputs of the expert predictors are combined using a weighting mechanism and a nonlinear fusion system. Using this prediction methodology the computational intractability of traditional acoustic propagation models is eliminated. The proposed system is tested on a synthetically generated acoustic data set for a wide range of geometric, source, environmental, and operational conditions. The results show a significant improvement in both accuracy and reliability over a benchmark prediction system. (C) 2011 Elsevier Ltd. All rights reserved. C1 [McCarron, Michael; Azimi-Sadjadi, Mahmood R.] Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. [Mungiole, Michael] USA, Res Lab, Attn AMSRD ARL CI ES, Adelphi, MD 20783 USA. RP Azimi-Sadjadi, MR (reprint author), Colorado State Univ, Dept Elect & Comp Engn, Ft Collins, CO 80523 USA. EM michael.v.mccarron@gmail.com; azimi@engr.colostate.edu FU DoD Center for Geosciences/Atmospheric Research at Colorado State University [W911NF-06-2-0015]; Army Research Laboratory FX This research was supported by the DoD Center for Geosciences/Atmospheric Research at Colorado State University under Cooperative Agreement W911NF-06-2-0015 with the Army Research Laboratory. NR 13 TC 2 Z9 2 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0893-6080 J9 NEURAL NETWORKS JI Neural Netw. PD MAR PY 2012 VL 27 BP 91 EP 99 DI 10.1016/j.neunet.2011.11.004 PG 9 WC Computer Science, Artificial Intelligence; Neurosciences SC Computer Science; Neurosciences & Neurology GA 901ZU UT WOS:000301009200010 PM 22196233 ER PT J AU Mondello, S Linnet, A Buki, A Robicsek, S Gabrielli, A Tepas, J Papa, L Brophy, GM Tortella, F Hayes, RL Wang, KK AF Mondello, Stefania Linnet, Akinyi Buki, Andras Robicsek, Steven Gabrielli, Andrea Tepas, Joseph Papa, Linda Brophy, Gretchen M. Tortella, Frank Hayes, Ronald L. Wang, Kevin K. TI Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury SO NEUROSURGERY LA English DT Article DE Biomarkers; Critical care; Diagnosis; Head injury; Outcome; Proteomics; UCH-L1 ID NEURON-SPECIFIC ENOLASE; SPECTRIN BREAKDOWN PRODUCTS; ALPHA-II-SPECTRIN; HEAD-INJURY; CEREBROSPINAL-FLUID; PROGNOSIS; PROTEIN; PROTEASOME; DIAGNOSIS; DAMAGE AB BACKGROUND: Brain damage markers released in cerebrospinal fluid (CSF) and blood may provide valuable information about diagnosis and outcome prediction after traumatic brain injury (TBI). OBJECTIVE: To examine the concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1), a novel brain injury biomarker, in CSF and serum of severe TBI patients and their association with clinical characteristics and outcome. METHODS: This case-control study enrolled 95 severe TBI subjects (Glasgow Coma Scale [GCS] score, 8). Using sensitive UCH-L1 sandwich ELISA, we studied the temporal profile of CSF and serum UCH-L1 levels over 7 days for severe TBI patients. RESULTS: Comparison of serum and CSF levels of UCH-L1 in TBI patients and control subjects shows a robust and significant elevation of UCH-L1 in the acute phase and over the 7-day study period. Serum and CSF UCH-L1 receiver-operating characteristic curves further confirm strong specificity and selectivity for diagnosing severe TBI vs controls, with area under the curve values in serum and CSF statistically significant at all time points up to 24 hours (P < .001). The first 12-hour levels of both serum and CSF UCH-L1 in patients with GCS score of 3 to 5 were also significantly higher than those with GCS score of 6 to 8. Furthermore, UCH-L1 levels in CSF and serum appear to distinguish severe TBI survivors from nonsurvivors within the study, with nonsurvivors having significantly higher and more persistent levels of serum and CSF UCH-L1. Cumulative serum UCH-L1 levels > 5.22 ng/mL predicted death (odds ratio, 4.8). CONCLUSION: Serum levels of UCH-L1 appear to have potential clinical utility in diagnosing TBI, including correlating to injury severity and survival outcome. C1 [Mondello, Stefania; Robicsek, Steven; Gabrielli, Andrea; Hayes, Ronald L.] Univ Florida, Dept Anesthesiol, Gainesville, FL USA. [Wang, Kevin K.] Univ Florida, Dept Psychiat, Ctr Neuroprote & Biomarkers Res, McKnight Brain Inst, Gainesville, FL 32611 USA. [Mondello, Stefania; Hayes, Ronald L.] Banyan Biomarkers Inc, Clin Dept, Ctr Innovat Res, Alachua, FL 32615 USA. [Wang, Kevin K.] Banyan Biomarkers Inc, Diagnost Res & Dev Dept, Ctr Innovat Res, Alachua, FL 32615 USA. [Buki, Andras] Univ Pecs, Dept Neurosurg, Pecs, Hungary. [Tepas, Joseph] Univ Florida, Dept Neurosurg, Jacksonville, FL USA. [Papa, Linda] Orlando Reg Med Ctr Inc, Orlando, FL USA. [Brophy, Gretchen M.] Virginia Commonwealth Univ, Richmond, VA USA. [Tortella, Frank] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD USA. RP Mondello, S (reprint author), Banyan Biomarkers Inc, Dept Clin Programs, 13400 Progress Blvd, Alachua, FL 32615 USA. EM stm_mondello@hotmail.com RI Mondello, Stefania/A-1813-2012; OI Mondello, Stefania/0000-0002-8587-3614; Wang, Kevin/0000-0002-9343-6473 FU National Institutes of Health [R01 NS049175-01, R01-NS052831-01, R01 NS051431-01]; Department of Defense [DAMD17-03-1-0772, DAMD17-03-1-0066]; University of Florida [N00014-06-1-1029] FX This study was supported in part by the National Institutes of Health (R01 NS049175-01, R01-NS052831-01, and R01 NS051431-01), supported in part by Department of Defense awards DAMD17-03-1-0772 and DAMD17-03-1-0066, National Institutes of Health awards, and Navy grant N00014-06-1-1029 (University of Florida). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or as reflecting true views of Department of the Army or Department of Defense. Drs Mondello, Buki, Robicsek, Gabrielli, Brophy, and Papa are consultants for Banyan Biomarkers, Inc. L. Akinyi is an employee of Banyan Biomarkers, Inc. Drs Wang and Hayes own stock, receive royalties from, and are officers of Banyan Biomarkers Inc and thus may benefit financially as a result of the outcomes of this research or work reported in this publication. Dr Tortella reports no disclosures. NR 42 TC 55 Z9 63 U1 0 U2 14 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD MAR PY 2012 VL 70 IS 3 BP 666 EP 675 DI 10.1227/NEU.0b013e318236a809 PG 10 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 898ZU UT WOS:000300781700024 PM 21937927 ER PT J AU Garrett, GA Rotella, P Shen, HG Wraback, M Haeger, DA Chung, RB Pfaff, N Young, EC DenBaars, SP Speck, JS Cohen, DA AF Garrett, Gregory A. Rotella, Paul Shen, Hongen Wraback, Michael Haeger, Daniel A. Chung, Roy B. Pfaff, Nathan Young, Erin C. DenBaars, Steven P. Speck, James S. Cohen, Daniel A. TI Carrier dynamics in active regions for ultraviolet optoelectronics grown on thick, relaxed AlGaN on semipolar bulk GaN SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS LA English DT Article DE semipolar AlGaN; time-resolved photoluminescence; ultraviolet laser diodes ID QUANTUM-WELLS AB Active regions for mid-ultraviolet laser diodes grown on bulk AlGaN templates are investigated by time-resolved photoluminescence. The active regions were grown pseudomorphically on thick, relaxed AlGaN on bulk GaN in the semi-polar ($20{\bar {2}}1$) orientation where it has been shown that the glide of dislocations create strain relieving defects confined to the AlGaN/GaN interface, away from the active region. The photoluminescence lifetimes were found to have mono-exponential decays of around 500?ps and calculated radiative and non-radiative lifetimes are compared to previously reported results for active regions on bulk m-plane GaN. C1 [Garrett, Gregory A.; Rotella, Paul; Shen, Hongen; Wraback, Michael] USA, Res Lab, Adelphi, MD 20783 USA. [Haeger, Daniel A.; Chung, Roy B.; Pfaff, Nathan; Young, Erin C.; DenBaars, Steven P.; Speck, James S.; Cohen, Daniel A.] Univ Calif Santa Barbara, Elect & Comp Engn & Mat Dept, Santa Barbara, CA 93106 USA. RP Garrett, GA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gregory.a.garrett@us.army.mil RI Young, Erin/J-5786-2013 NR 10 TC 0 Z9 0 U1 1 U2 21 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0370-1972 J9 PHYS STATUS SOLIDI B JI Phys. Status Solidi B-Basic Solid State Phys. PD MAR PY 2012 VL 249 IS 3 BP 507 EP 510 DI 10.1002/pssb.201100528 PG 4 WC Physics, Condensed Matter SC Physics GA 897XZ UT WOS:000300696500016 ER PT J AU Ely, MR Ely, BR Chinevere, TD Lacher, CP Lukaski, HC Cheuvront, SN AF Ely, M. R. Ely, B. R. Chinevere, T. D. Lacher, C. P. Lukaski, H. C. Cheuvront, S. N. TI Evaluation of the Megaduct sweat collector for mineral analysis SO PHYSIOLOGICAL MEASUREMENT LA English DT Article DE Macroduct; Wescor; exercise-heat stress; sweat rate; mineral ID PROLONGED EXERCISE; HEAT ACCLIMATION; CYSTIC-FIBROSIS; WHOLE-BODY; ARM-BAG; LOSSES; IRON; CHLORIDE; ZINC; TEMPERATURES AB Accurate measurement of sweat mineral loss is important for whole body mineral balance estimates and dietary reference intake formulation. Currently, common localized sweat collection methods such as the pouch and patch techniques may be limited by skin encapsulation and/or hidromeiosis, which may alter sweat mineral concentrations. The design of the newly developed Megaduct sweat collector may avoid these possible limitations. Therefore, the purpose of this study was to evaluate the utility of the Megaduct sweat collector for mineral analysis. Megaduct sweat collectors were affixed to ten volunteers on the final day of a heat acclimation protocol; collection time, sweat volume, and mineral concentrations of calcium, copper, iron, potassium, sodium, and zinc were measured. Megaduct filling required a collection period of 62 +/- 3 min due to a small collection surface (22.1 cm(2)). The mineral content of the sweat was 0.3 +/- 0.1 mmol L-1, 1.5 +/- 1.5 mu mol L-1, 8.5 +/- 2.1 mmol L-1, 43.2 +/- 15.0 mmol L-1, and 10.1 +/- 5.7 mu mol L-1 for Ca, Cu, K, Na, and Zn, respectively. The Megaduct sweat collector appears to avoid skin encapsulation and hidromeiosis, and captures sweat with similar mineral concentrations as reported in the literature for pouches. However, the filling time of the Megaduct (>60 min) may not capture possible changes in sweat mineral concentrations that are documented to occur in as little as 15 to 30 min. C1 [Ely, M. R.; Ely, B. R.; Chinevere, T. D.; Cheuvront, S. N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Lacher, C. P.; Lukaski, H. C.] USDA, Human Nutr Res Ctr, Grand Forks, ND USA. RP Ely, MR (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM matthew.ely@us.army.mil OI Ely, Matthew/0000-0002-0618-7078 NR 40 TC 6 Z9 6 U1 1 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0967-3334 EI 1361-6579 J9 PHYSIOL MEAS JI Physiol. Meas. PD MAR PY 2012 VL 33 IS 3 BP 385 EP 394 DI 10.1088/0967-3334/33/3/385 PG 10 WC Biophysics; Engineering, Biomedical; Physiology SC Biophysics; Engineering; Physiology GA 901SM UT WOS:000300987100008 PM 22369987 ER PT J AU Hatchell, BK Mauss, FJ Amaya, IA Skorpik, JR Silvers, KL Marotta, SA AF Hatchell, Brian K. Mauss, Fredrick J. Amaya, Ivan A. Skorpik, James R. Silvers, Kurt L. Marotta, Stephen A. TI Missile captive carry monitoring and helicopter identification using a capacitive microelectromechanical systems accelerometer SO STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL LA English DT Article DE structural health monitoring; Goertzel algorithm; health and usage monitoring systems; ambient vibration; microelectromechanical systems; accelerometer ID GEARBOX FAULT-DETECTION; VIBRATION AB Military missiles are exposed to many sources of mechanical vibration that can affect system reliability, safety, and mission effectiveness. The US Army Aviation and Missile Research Development and Engineering Center has been developing missile health monitoring systems to assess and improve reliability, reduce life cycle costs, and increase system readiness. One of the most significant exposures to vibration occurs when the missile is being carried by a helicopter or other aviation platform, which is a condition known as captive carry. Recording the duration of captive carry exposure during the missile's service life can enable the implementation of predictive maintenance and resource management programs. Since the vibration imparted by each class of helicopter varies in frequency and amplitude, tracking the vibration exposure from each helicopter separately can help quantify the severity and harmonic content of the exposure. To help address these needs, the authors have developed a captive carry health monitor for the Hellfire II missile. The captive carry health monitor is an embedded usage monitoring device installed on the outer skin of the Hellfire II missile to record the cumulative hours the host missile has been in captive carry mode. To classify the vibration by class of helicopter, the captive carry health monitor analyzes the amplitude and frequency content of the vibration with the Goertzel algorithm to detect the presence of distinctive rotor harmonics. This article provides an overview of the captive carry health monitor, presents vibration data collected on missiles during captive carry, describes data analysis techniques used to monitor captive carry and identify the class of helicopter, and discusses the potential application of missile health and usage data for real-time reliability analysis. More broadly, this article illuminates the challenges of developing a structural health monitor to classify transportation modes in an unstructured environment. C1 [Hatchell, Brian K.; Mauss, Fredrick J.; Amaya, Ivan A.; Skorpik, James R.; Silvers, Kurt L.] Pacific NW Natl Lab, Richland, WA 99352 USA. [Marotta, Stephen A.] USA, AMRDEC, Redstone Arsenal, AL USA. RP Hatchell, BK (reprint author), Pacific NW Natl Lab, POB 999, Richland, WA 99352 USA. EM brian.hatchell@pnl.gov FU US Army Joint Attack Munition Systems (JAMS) Project Management Office [AGRD19D1021D1] FX This work was supported by the US Army Joint Attack Munition Systems (JAMS) Project Management Office under interagency agreement AGRD19D1021D1. NR 18 TC 1 Z9 1 U1 1 U2 8 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1475-9217 J9 STRUCT HEALTH MONIT JI Struct. Health Monit. PD MAR PY 2012 VL 11 IS 2 BP 213 EP 224 DI 10.1177/1475921711414237 PG 12 WC Engineering, Multidisciplinary; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 899TX UT WOS:000300840400008 ER PT J AU McLain, DE Lewis, BS Chapman, JL Wannemacher, RW Lindsey, CY Smith, LA AF McLain, Daniel E. Lewis, Bridget S. Chapman, Jennifer L. Wannemacher, Robert W. Lindsey, Changhong Y. Smith, Leonard A. TI Protective Effect of Two Recombinant Ricin Subunit Vaccines in the New Zealand White Rabbit Subjected to a Lethal Aerosolized Ricin Challenge: Survival, Immunological Response, and Histopathological Findings SO TOXICOLOGICAL SCIENCES LA English DT Article DE ricin toxin; biological threat agent; recombinant ricin subunit vaccine ID POLYMERIC MICROSPHERES; A-CHAIN; MICE; INFECTIONS; TOXICITY AB Editor's Hightlight: Ricin is a highly toxic agent that could be utilized as a bioterrorism weapon. This study tested the efficacy of two different recombinant ricin subunit vaccines to protect against ricin administered via inhalation exposure. Both vaccines were found to be effective in preventing the lethal effects of ricin exposure. This study supports the potential use of ricin vaccines in human populations at risk of ricin exposure.Ricin, isolated from the castor bean plant Ricinus communis, is included on the Centers for Disease Control and Prevention Category B list of bioterrorism agents, indicating that the toxin is moderately easy to disseminate and could result in moderate morbidity rates. This study evaluated two promising recombinant ricin subunit vaccines, one made using an Escherichia coli codon-optimized gene and the other using a yeast codon-optimized gene in E. coli-based fermentations. Rabbits were vaccinated four times over a period of 6 months and challenged with similar to 10 to 30 times the median lethal dose of aerosolized ricin. All unvaccinated control rabbits were either found dead or humanely euthanized within 30 h postchallenge, while the rabbits vaccinated with either vaccine survived the exposure without adverse clinical signs. When the protective antibody responses were analyzed, no significant difference was seen between the two vaccines. However, there was a significant difference in the immune response over time for both vaccines tested. Although clinical pathology was unremarkable, significant histological lesions in the control animals included fibrinonecrotic pneumonia, acute necrotizing lesions in the upper respiratory tract, and necrotizing lymphadenitis in the lymph nodes draining the upper and lower respiratory tract. Vaccine-treated rabbits exhibited resolving lesions associated with ricin exposure, namely chronic inflammation in the upper respiratory tract and lungs, fibrosis, type II pneumocyte hyperplasia, and bronchiolitis obliterans. This study confirmed the safety and efficacy of two recombinant ricin subunit vaccines in rabbits, offering potential protection to warfighters and select populations. C1 [Lewis, Bridget S.; Chapman, Jennifer L.; Wannemacher, Robert W.; Lindsey, Changhong Y.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [McLain, Daniel E.] Walker Downey & Associates Inc, Verona, WI 53593 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM leonard.smith@amedd.army.mil FU Joint Science and Technology Office for Chemical-Biological Defense FX Joint Science and Technology Office for Chemical-Biological Defense. NR 22 TC 14 Z9 15 U1 1 U2 8 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1096-6080 J9 TOXICOL SCI JI Toxicol. Sci. PD MAR PY 2012 VL 126 IS 1 BP 72 EP 83 DI 10.1093/toxsci/kfr274 PG 12 WC Toxicology SC Toxicology GA 901TI UT WOS:000300989300008 PM 21987460 ER PT J AU Venegas, J Cooper, TV Naylor, N Hanson, BS Blow, JA AF Venegas, Jennifer Cooper, Theodore V. Naylor, Natasha Hanson, Brenda S. Blow, Julie A. TI Potential Cultural Predictors of Heavy Episodic Drinking in Hispanic College Students SO AMERICAN JOURNAL ON ADDICTIONS LA English DT Article ID HIGH-RISK DRINKING; ALCOHOL-USE; PARTIAL BAN; ACCULTURATION; ADOLESCENT; AMERICANS; GENDER; BORDER; DEPENDENCE; DRINKERS AB Heavy alcohol use in college students is a serious health risk. It is unclear how cultural variables impact alcohol use in Hispanic college populations. Here, the relationships between gender, bicultural identity, familism, and adherence to traditional gender roles with heavy episodic drinking (HED) in a Hispanic college sample are assessed. Participants, 80 males and 80 females, were asked to complete a questionnaire packet, which assessed demographic information, as well as measures designed to rate drinking amount and frequency, bicultural integration, familism, and traditional gender role adherence. Average age of the sample was 19.9 years (SD = 3.05), in which the majority of participants were classified as either Freshmen or Sophomores (88.8%). Overall, 47.5% of participants reported engaging in HED, with 51% of men and 44% of women reporting HED. Univariate analyses along with logistic regression were utilized to assess possible differences and correlates of HED. Neither individual predictors nor the overall model were statistically significant. These findings suggest the need for continued assessment of HED in Hispanic college students using other culturally based constructs, as well as psychosocial factors that are found to predict heavy drinking in other ethnocultural college-aged students. (Am J Addict 2012;00:1-5) C1 [Cooper, Theodore V.; Blow, Julie A.] Univ Texas El Paso, Dept Psychol, El Paso, TX 79968 USA. [Venegas, Jennifer; Naylor, Natasha] Univ Utah, Salt Lake City, UT USA. [Hanson, Brenda S.] USA, TRADOC Anal Ctr, White Sands Missile Range, NM USA. RP Cooper, TV (reprint author), Univ Texas El Paso, Dept Psychol, 500 W Univ Ave, El Paso, TX 79968 USA. EM tvcooper@utep.edu NR 35 TC 14 Z9 14 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1055-0496 J9 AM J ADDICTION JI Am. J. Addict. PD MAR-APR PY 2012 VL 21 IS 2 BP 145 EP 149 DI 10.1111/j.1521-0391.2011.00206.x PG 5 WC Substance Abuse SC Substance Abuse GA 894SO UT WOS:000300447300008 PM 22332858 ER PT J AU Hamilton, JB Agarwal, M Song, LX Moore, MAJAD Best, N AF Hamilton, Jill B. Agarwal, Mansi Song, Lixin Moore, M. A. J. Angelo D. Best, Nakia TI Are Psychosocial Interventions Targeting Older African American Cancer Survivors Culturally Appropriate? A Review of the Literature SO CANCER NURSING LA English DT Review DE African Americans; Cancer; Culturally appropriate strategies; Psychosocial interventions; Review of literature ID LOW-INCOME WOMEN; BREAST-CANCER; PROSTATE-CANCER; PSYCHOLOGICAL ADJUSTMENT; FUNCTIONAL ASSESSMENT; RACIAL-DIFFERENCES; FAMILY CAREGIVERS; SOCIAL SUPPORT; LUNG-CANCER; HEALTH AB Background: The alleviation of cancer health disparities makes it necessary to understand and apply the knowledge about cultural behaviors in the design of interventions deemed culturally appropriate. Objective: This review aimed to provide an overview of the ways in which strategies were used to facilitate the cultural appropriateness of psychosocial interventions delivered to African American cancer survivors. Methods: An electronic and hand search of 5 major databases was performed to identify intervention studies that targeted African American cancer patients/survivors 50 years or older. We review researchers' efforts to achieve culturally appropriate intervention research by evaluating whether peripheral, evidential, linguistic, constituent-involving, or sociocultural strategies were used. Results: Only 6 intervention studies met the criteria for inclusion in this review, with each study using 1 or more strategies to achieve cultural appropriateness. However, few studies incorporated sociocultural factors in the intervention design. Conclusion: Strategies to achieve cultural appropriateness in psychosocial interventions targeting older African Americans have focused more on enhancing recruitment and retention and less on the inclusion of sociocultural concepts into the content of the intervention. Implications for Practice: Intervention studies delivered to older African American cancer patients/survivors should aim to incorporate those concepts of relevance to the population and likely to facilitate healthcare outcomes. C1 [Hamilton, Jill B.; Agarwal, Mansi; Song, Lixin; Best, Nakia] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA. [Moore, M. A. J. Angelo D.] USA, Tripler Army Med Ctr, Honolulu, HI USA. RP Hamilton, JB (reprint author), Univ N Carolina, Sch Nursing, CB 7460, Chapel Hill, NC 27599 USA. EM jhamilto@email.unc.edu NR 70 TC 4 Z9 4 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0162-220X J9 CANCER NURS JI Cancer Nurs. PD MAR-APR PY 2012 VL 35 IS 2 BP E12 EP E23 DI 10.1097/NCC.0b013e31821e0b11 PG 12 WC Oncology; Nursing SC Oncology; Nursing GA 897EI UT WOS:000300627100002 PM 21760495 ER PT J AU Zhong, XL Pandey, R Karna, SP AF Zhong, Xiaoliang Pandey, Ravindra Karna, Shashi P. TI Stacking dependent electronic structure and transport in bilayer graphene nanoribbons SO CARBON LA English DT Article ID CARBON NANOTUBES; STATE; RIBBONS; GATE AB The stacking-dependent electronic structure and transport properties of bilayer graphene nanoribbons suspended between gold electrodes are investigated using density functional theory coupled with non-equilibrium Green's functional method. We find substantially enhanced electron transmission as well as tunneling currents in the AA stacking of bilayer nanoribbons compared to either single-layer or AB stacked bilayer nanoribbons. Interlayer separation between the nanoribbons appears to have a profound impact on the conducting features of the bilayer nanoribbons, which is found to be closely related to the topology and overlap between the edge-localized pi orbitals. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Zhong, Xiaoliang; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu RI Zhong, Xiaoliang/B-2220-2012 FU Army Research Office [W911NF-09-1-0221] FX Helpful discussions with Dr. Ranjit Pati and Saikat Mukhopadhyay are acknowledged. The work at Michigan Technological University was performed under support by the Army Research Office through Contract Number W911NF-09-1-0221. NR 37 TC 25 Z9 25 U1 0 U2 15 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD MAR PY 2012 VL 50 IS 3 BP 784 EP 790 DI 10.1016/j.carbon.2011.09.033 PG 7 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 895BR UT WOS:000300471700006 ER PT J AU Goethals, PL Cho, BR AF Goethals, P. L. Cho, B. R. TI Extending the desirability function to account for variability measures in univariate and multivariate response experiments SO COMPUTERS & INDUSTRIAL ENGINEERING LA English DT Article DE Desirability function; Multi-response optimization; Robust design; Response surface methodology ID ROBUST DESIGN OPTIMIZATION; MULTIRESPONSE OPTIMIZATION; SURFACE OPTIMIZATION; TAGUCHI METHOD; BIAS; REGRESSION; VARIANCE; PRODUCTS AB One technique used frequently among quality practitioners seeking solutions to multi-response optimization problems is the desirability function approach. The technique involves modeling each characteristic using response surface designs and then transforming the characteristics into a single performance measure. The traditional procedure, however, calls for estimating only the mean response: the variability among the characteristics is not considered. Furthermore, the approach typically relies on the accuracy of second-order polynomials in its estimation, which are not always suitable. This paper, in contrast. proposes a methodology that utilizes higher-order estimation techniques and incorporates the concepts of robust design to account for process variability. Several examples are provided to illustrate the effectiveness of the proposed methodology. Published by Elsevier Ltd. C1 [Goethals, P. L.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Cho, B. R.] Clemson Univ, Dept Ind Engn, Clemson, SC 29634 USA. RP Goethals, PL (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM paul.goethals@usma.edu; bcho@clemson.edu NR 47 TC 9 Z9 10 U1 2 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-8352 J9 COMPUT IND ENG JI Comput. Ind. Eng. PD MAR PY 2012 VL 62 IS 2 BP 457 EP 468 DI 10.1016/j.cie.2011.10.012 PG 12 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA 898OI UT WOS:000300751300005 ER PT J AU Batchinsky, AI Chung, KK Cancio, LC AF Batchinsky, Andriy I. Chung, Kevin K. Cancio, Leopoldo C. TI Airway pressure release ventilation requires spontaneous breathing for full benefits Reply SO CRITICAL CARE MEDICINE LA English DT Letter ID RESPIRATORY-DISTRESS SYNDROME; SMOKE-INHALATION INJURY; MECHANICAL VENTILATION; OUTCOMES; REMOVAL C1 [Batchinsky, Andriy I.; Chung, Kevin K.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD MAR PY 2012 VL 40 IS 3 BP 1041 EP 1042 DI 10.1097/CCM.0b013e318246b37b PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 895YO UT WOS:000300532800086 ER PT J AU Yancosek, KE Roy, T Erickson, M AF Yancosek, Kathleen E. Roy, Tanja Erickson, Mary TI Rehabilitation programs for musculoskeletal injuries in military personnel SO CURRENT OPINION IN RHEUMATOLOGY LA English DT Review DE military deployment; musculoskeletal injuries; rehabilitation ID OPERATION IRAQI FREEDOM; BRIGADE COMBAT TEAM; ENDURING FREEDOM; US ARMY; PHYSICAL-THERAPY; OUTPATIENT VISITS; NONBATTLE INJURY; RISK-FACTORS; SOLDIERS; SURVEILLANCE AB Purpose of review The purpose of this review is to summarize current trends and rehabilitation programs for musculoskeletal injuries in military personnel returning from deployment. Recent findings Musculoskeletal injuries (MSIs) are the leading healthcare problem for military members. Risk factors inparticipation in sports, carrying heavy loads, older age, female sex, standing for long periods of time, and walking long distances. MSIs may lead to medical discharge from the military. Physical and occupational therapists work at the Combat Support Hospitals to provide rehabilitation care to injured personnel and reduce recovery time by 60% and costs by 123%. The Army Medical Department has developed initiatives to decrease the burden of MSI: musculoskeletal screening and referral tools to assist military medical providers in managing patients with MSI; Pain Management Task Force to optimize care for wounded soldiers; Musculoskeletal Action Plan for injury prevention, early diagnosis and management, and rehabilitation/reintegration following injury; and Musculoskeletal Action Teams to work with military recruits who make up the largest subgroup in the Army with the highest incidence of MSIs. Summary The US Military is aware of the inherent risks for MSI associated with military training and repeated combat deployments. Rehabilitation efforts have been developed to address the problem. C1 [Yancosek, Kathleen E.] USA, Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. [Roy, Tanja] Univ Pittsburgh, Rehabil Sci Dept, Pittsburgh, PA 15260 USA. [Erickson, Mary] Proponency Off Rehabil & Reintegrat, Off Surg Gen, Falls Church, VA USA. RP Yancosek, KE (reprint author), USA, Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM kathleen.yancosek@us.army.mil NR 30 TC 7 Z9 7 U1 0 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-8711 J9 CURR OPIN RHEUMATOL JI Curr. Opin. Rheumatol. PD MAR PY 2012 VL 24 IS 2 BP 232 EP 236 DI 10.1097/BOR.0b013e3283503406 PG 5 WC Rheumatology SC Rheumatology GA 893VZ UT WOS:000300387100017 PM 22249351 ER PT J AU Zhang, VM Chavchich, M Waters, NC AF Zhang, Veronica M. Chavchich, Marina Waters, Norman C. TI Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target SO CURRENT TOPICS IN MEDICINAL CHEMISTRY LA English DT Review DE Antimalarial agents; drug development; kinase family; Plasmodium falciparum; plasmodiual protein kinases; protein kinases ID GLYCOGEN-SYNTHASE KINASE-3; STAGE-SPECIFIC EXPRESSION; RING FINGER PROTEIN; NIMA-RELATED KINASE; B-LIKE ENZYME; PLASMODIUM-FALCIPARUM; CELL-CYCLE; SELECTIVE INHIBITORS; MAP KINASE; FUNCTIONAL-CHARACTERIZATION AB Millions of deaths each year are attributed to malaria worldwide. Transmitted through the bite of an Anopheles mosquito, infection and subsequent death from the Plasmodium species, most notably P. falciparum, can readily spread through a susceptible population. A malaria vaccine does not exist and resistance to virtually every antimalarial drug predicts that mortality and morbidity associated with this disease will increase. With only a few antimalarial drugs currently in the pipeline, new therapeutic options and novel chemotypes are desperately needed. Hit- to- Lead diversity may successfully provide novel inhibitory scaffolds when essential enzymes are targeted, for example, the plasmodial protein kinases. Throughout the entire life cycle of the malaria parasite, protein kinases are essential for growth and development. Ongoing efforts continue to characterize these kinases, while simultaneously pursuing them as antimalarial drug targets. A collection of structural data, inhibitory profiles and target validation has set the foundation and support for targeting the malarial kinome. Pursuing protein kinases as cancer drug targets has generated a wealth of information on the inhibitory strategies that can be useful for antimalarial drug discovery. In this review, progress on selected protein kinases is described. As the search for novel antimalarials continues, an understanding of the phosphor- regulatory pathways will not only validate protein kinase targets, but also will identify novel chemotypes to thwart malaria drug resistance. C1 [Waters, Norman C.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Zhang, Veronica M.; Chavchich, Marina; Waters, Norman C.] Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. [Zhang, Veronica M.; Chavchich, Marina; Waters, Norman C.] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia. RP Waters, NC (reprint author), US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM norman.waters@us.army.mil NR 179 TC 20 Z9 20 U1 1 U2 30 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1568-0266 J9 CURR TOP MED CHEM JI Curr. Top. Med. Chem. PD MAR PY 2012 VL 12 IS 5 BP 456 EP 472 PG 17 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 897FG UT WOS:000300631000006 PM 22242850 ER PT J AU Milner, E Sousa, J Pybus, B Auschwitz, J Caridha, D Gardner, S Grauer, K Harris, E Hickman, M Kozar, MP Lee, P Leed, S Li, QG Melendez, V Moon, J Ngundam, F O'Neil, M Parriott, S Potter, B Sciotti, R Tangteung, A Dow, GS AF Milner, Erin Sousa, Jason Pybus, Brandon Auschwitz, Jennifer Caridha, Diana Gardner, Sean Grauer, Kristina Harris, Erin Hickman, Mark Kozar, Michael P. Lee, Patricia Leed, Susan Li, Qigui Melendez, Victor Moon, Jay Ngundam, Franklyn O'Neil, Michael Parriott, Sandi Potter, Brittney Sciotti, Rick Tangteung, Anchalee Dow, Geoffrey S. TI Ketotifen is an antimalarial prodrug of norketotifen with blood schizonticidal and liver-stage efficacy SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS LA English DT Article DE Malaria drug development; Ketotifen; Blood-stage malaria; Liver-stage malaria ID METABOLISM; HEPATOCYTES; RESISTANCE; INVITRO; MALARIA AB Ketotifen is known to exhibit antimalarial activity in mouse and monkey malaria models. However, the low plasma levels and short half life of the drug do not adequately explain its in vivo efficacy. We synthesized most of the known metabolites of ketotifen and evaluated their antimalarial activity and pharmacokinetics in mice. Norketotifen, the de-methylated metabolite of ketotifen, was a more potent antimalarial in vitro as compared to ketotifen, and exhibited equivalent activity in vivo against asexual blood and developing liver-stage parasites. After ketotifen dosing, norketotifen levels were much higher than ketotifen relative to the IC50s of the compounds against Plasmodium falciparum in vitro. The data support the notion that the antimalarial activity of ketotifen in mice is mediated through norketotifen. C1 [Milner, Erin; Sousa, Jason; Pybus, Brandon; Auschwitz, Jennifer; Caridha, Diana; Gardner, Sean; Grauer, Kristina; Harris, Erin; Hickman, Mark; Kozar, Michael P.; Lee, Patricia; Leed, Susan; Li, Qigui; Melendez, Victor; Moon, Jay; Ngundam, Franklyn; O'Neil, Michael; Parriott, Sandi; Potter, Brittney; Sciotti, Rick; Dow, Geoffrey S.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Tangteung, Anchalee] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. RP Milner, E (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. EM erin.milner@amedd.army.mil RI Sousa, Jason/A-9177-2011; Sciotti, Richard/A-9069-2011; Potter, Brittney/E-2216-2013 NR 18 TC 7 Z9 7 U1 0 U2 6 PU SPRINGER FRANCE PI PARIS PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE SN 0378-7966 J9 EUR J DRUG METAB PH JI Eur. J. Drug Metabol. Pharmacokinet. PD MAR PY 2012 VL 37 IS 1 BP 17 EP 22 DI 10.1007/s13318-012-0080-2 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 898WF UT WOS:000300772400003 PM 22314893 ER PT J AU Arabshahi, B Silverman, RA Jones, OY Rider, LG AF Arabshahi, Bita Silverman, Robert A. Jones, Olcay Y. Rider, Lisa G. TI Abatacept and Sodium Thiosulfate for Treatment of Recalcitrant Juvenile Dermatomyositis Complicated by Ulceration and Calcinosis SO JOURNAL OF PEDIATRICS LA English DT Article ID RHEUMATOID-ARTHRITIS AB We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis. (J Pediatr 2012;160:520-2) C1 [Arabshahi, Bita] Inova Fairfax Hosp Children, Div Pediat Rheumatol, Dept Pediat, Fairfax, VA USA. [Silverman, Robert A.] Georgetown Univ, Dept Pediat, Washington, DC 20057 USA. [Jones, Olcay Y.] Walter Reed Army Med Ctr, Dept Pediat, Div Pediat Rheumatol, Washington, DC 20307 USA. [Jones, Olcay Y.; Rider, Lisa G.] George Washington Univ, Dept Med, Ctr Myositis, Washington, DC USA. [Rider, Lisa G.] Natl Inst Environm Hlth Sci, Environm Autoimmun Grp, Program Clin Res, NIH,US Dept HHS, Bethesda, MD USA. RP Arabshahi, B (reprint author), Inova Fairfax Pediat Subspecialty Ctr, 8505 Arlington Blvd,Suite 100, Fairfax, VA 22031 USA. EM bita.arabshahi@inova.org OI Rider, Lisa/0000-0002-6912-2458 FU National Institute of Environmental Health Sciences, National Institutes of Health; Cure JM Foundation; Inova Fairfax Hospital for Children, Inova Health System Foundation FX Supported by the intramural research program of the National Institute of Environmental Health Sciences, National Institutes of Health; the Cure JM Foundation; and the Mohsen Ziai, MD Pediatric Endowment at Inova Fairfax Hospital for Children, Inova Health System Foundation. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of Defense or the US Government. The authors declare no conflicts of interest. NR 11 TC 30 Z9 32 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR-US JI J. Pediatr. PD MAR PY 2012 VL 160 IS 3 BP 520 EP 522 DI 10.1016/j.jpeds.2011.11.057 PG 3 WC Pediatrics SC Pediatrics GA 897AT UT WOS:000300613700035 PM 22244459 ER PT J AU Santtila, M Hakkinen, K Nindl, BC Kyrolainen, H AF Santtila, Matti Hakkinen, Keijo Nindl, Bradley C. Kyrolainen, Heikki TI CARDIOVASCULAR AND NEUROMUSCULAR PERFORMANCE RESPONSES INDUCED BY 8 WEEKS OF BASIC TRAINING FOLLOWED BY 8 WEEKS OF SPECIALIZED MILITARY TRAINING SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE soldier; endurance training; strength training; basic training; special training ID BRITISH ARMY RECRUITS; PHYSICAL-FITNESS; AEROBIC FITNESS; CONCURRENT RESISTANCE; FEMALE CADETS; RISK-FACTORS; BODY-FAT; ENDURANCE; STRENGTH; MEN AB Santtila, M, Hakkinen, K, Nindl, BC, and Kyrolainen, H. Cardiovascular and neuromuscular performance responses induced by 8 weeks of basic training followed by 8 weeks of specialized military training. J Strength Cond Res 26(3): 745751, 2012-The purpose of this study was to examine the changes in cardiovascular and neuromuscular performances induced by 8 weeks of basic training (BT) period followed by 8 weeks of special training period (STP). Fifty-seven male soldiers (age: 19.2 +/- 0.9 years, height: 1.79 +/- 0.06 m, body mass: 73.8 +/- 12.4 kg) volunteered for tests of peak oxygen uptake ((V)over dotO(2)peak) and maximal bilateral isometric force of the leg and arm extensor muscles. During the first 8 weeks, ((V)over dotO(2)peak) increased by 5.6% (45.0 +/- 8 vs. 48.8 +/- 7 ml.kg(-1).min(-1)), but no further changes were observed during the next 8 weeks (49.1 +/- 8 ml.kg(-1).min(-1)). Maximal isometric force of the arm and leg extensors increased during the first 8 weeks (arm: 680 +/- 182 vs. 774 +/- 182 N; leg: 2,584 +/- 724 vs. 2,730 +/- 823 N) by 3.8% (p < 0.001) and 8.1% (p < 0.001), respectively, with no further increases by week 16 (arm: 718 +/- 170 N; leg: 2,679 +/- 967 N). Body fat percentage (pre: 10.4 +/- 4, post-BT: 9.0 +/- 4, post-STP: 9.3 +/- 3%), and waist circumference decreased (83.4 +/- 10, 80.9 +/- 8, 80.8 +/- 7 cm) during BT, whereas no changes were noticed thereafter. In conclusion, it was found that physical fitness of conscripts improved significantly during the Finnish military 8-week BT at the beginning of their military service. A plateau in the improvement of physical performance during STP is largely attributed to a lack of continued progression or periodization in their training program. For optimal improvements in physical performance during STP, it might be reasonable to include a structured physical training with greater intensity and training volume with optimal periodization than during BT. C1 [Santtila, Matti] Personnel Div Def Command, Def Forces, Helsinki, Finland. [Hakkinen, Keijo; Kyrolainen, Heikki] Univ Jyvaskyla, Dept Biol Phys Act, Jyvaskyla, Finland. [Nindl, Bradley C.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Kyrolainen, Heikki] Natl Def Univ, Dept Leadership & Mil Pedag, Helsinki, Finland. RP Santtila, M (reprint author), Personnel Div Def Command, Def Forces, Helsinki, Finland. EM matti.santtila@mil.fi FU Scientific Board for National Defence; Ministry of Education, Finland; Foundation of Sport Institute; Foundation of Werner Hacklin FX This study was supported in part by grants from the Scientific Board for National Defence, the Ministry of Education, Finland, the Foundation of Sport Institute, and the Foundation of Werner Hacklin. The authors would like to express their special thanks to Elina Maria Kokkonen for the statistical analysis. NR 34 TC 7 Z9 7 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAR PY 2012 VL 26 IS 3 BP 745 EP 751 DI 10.1519/JSC.0b013e31822b72f1 PG 7 WC Sport Sciences SC Sport Sciences GA 897GA UT WOS:000300633900021 PM 22289701 ER PT J AU Ryan, EJ Kim, CH Muller, MD Bellar, DM Barkley, JE Bliss, MV Jankowski-Wilkinson, A Russell, M Otterstetter, R Macander, D Glickman, EL Kamimori, GH AF Ryan, Edward J. Kim, Chul-Ho Muller, Matthew D. Bellar, David M. Barkley, Jacob E. Bliss, Matthew V. Jankowski-Wilkinson, Andrea Russell, Morgan Otterstetter, Ronald Macander, Daniela Glickman, Ellen L. Kamimori, Gary H. TI LOW-DOSE CAFFEINE ADMINISTERED IN CHEWING GUM DOES NOT ENHANCE CYCLING TO EXHAUSTION SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE nutrition; metabolism; performance; ergogenic aid ID LEG-MUSCLE PAIN; NORMAL HEALTHY-VOLUNTEERS; ENDURANCE PERFORMANCE; EXERCISE ENDURANCE; INGESTION; METABOLISM; PLASMA; TIME; RESPONSES; COFFEE AB Ryan, EJ, Kim, C-H, Muller, MD, Bellar, DM, Barkley, JE, Bliss, MV, Jankowski-Wilkinson, A, Russell, M, Otterstetter, R, Macander, D, Glickman, EL, and Kamimori, GH. J Strength Cond Res 26(3): 844-850, 2012-Low-dose caffeine administered in chewing gum does not enhance cycling to exhaustion. The purpose of the current investigation was to examine the effect of low-dose caffeine (CAF) administered in chewing gum at 3 different time points during submaximal cycling exercise to exhaustion. Eight college-aged (26 +/- 4 years), physically active (45.5 +/- 5.7 ml.kg(-1).min(-1)) volunteers participated in 4 experimental trials. Two pieces of caffeinated chewing gum (100 mg per piece, total quantity of 200 mg) were administered in a double-blind manner at 1 of 3 time points (-35, -5, and +15 minutes) with placebo at the other 2 points and at all 3 points in the control trial. The participants cycled at 85% of maximal oxygen consumption until volitional fatigue and time to exhaustion (TTE) were recorded in minutes. Venous blood samples were obtained at -40, -10, and immediately postexercise and analyzed for serum-free fatty acid and plasma catecholamine concentrations. Oxygen consumption, respiratory exchange ratio, heart rate, glucose, lactate, ratings of perceived exertion, and perceived leg pain measures were obtained at baseline and every 10 minutes during cycling. The results showed that there were no significant differences between the trials for any of the parameters measured including TTE. These findings suggest that low-dose CAF administered in chewing gum has no effect on TTE during cycling in recreational athletes and is, therefore, not recommended. C1 [Ryan, Edward J.; Kim, Chul-Ho; Muller, Matthew D.; Bellar, David M.; Barkley, Jacob E.; Bliss, Matthew V.; Glickman, Ellen L.] Kent State Univ, Dept Exercise Physiol, Kent, OH 44242 USA. [Jankowski-Wilkinson, Andrea; Russell, Morgan; Otterstetter, Ronald] Univ Akron, Dept Sport Sci & Wellness Educ, Akron, OH 44325 USA. [Macander, Daniela; Kamimori, Gary H.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Ryan, EJ (reprint author), Kent State Univ, Dept Exercise Physiol, Kent, OH 44242 USA. EM eryan4@kent.edu OI Barkley, Jacob/0000-0002-4254-4626 NR 38 TC 5 Z9 5 U1 2 U2 21 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAR PY 2012 VL 26 IS 3 BP 844 EP 850 DI 10.1519/JSC.0b013e31822a5cd4 PG 7 WC Sport Sciences SC Sport Sciences GA 897GA UT WOS:000300633900035 PM 22293680 ER PT J AU Dower, K Filone, CM Hodges, EN Bjornson, ZB Rubins, KH Brown, LE Schaus, S Hensley, LE Connor, JH AF Dower, Ken Filone, Claire Marie Hodges, Erin N. Bjornson, Zach B. Rubins, Kathleen H. Brown, Lauren E. Schaus, Scott Hensley, Lisa E. Connor, John H. TI Identification of a Pyridopyrimidinone Inhibitor of Orthopoxviruses from a Diversity-Oriented Synthesis Library SO JOURNAL OF VIROLOGY LA English DT Article ID ISATIN-BETA-THIOSEMICARBAZONE; VACCINIA VIRUS; GENE-EXPRESSION; DNA-REPLICATION; MONKEYPOX; ST-246; TRANSCRIPTION; SMALLPOX; PROTEIN; RNA AB Orthopoxviruses include the prototypical vaccinia virus, the emerging infectious agent monkeypox virus, and the potential bio-threat variola virus (the causative agent of smallpox). There is currently no FDA-approved drug for humans infected with orthopoxviruses. We screened a diversity-oriented synthesis library for new scaffolds with activity against vaccinia virus. This screen identified a nonnucleoside analog that blocked postreplicative intermediate and late gene expression. Viral genome replication was unaffected, and inhibition could be elicited late in infection and persisted upon drug removal. Sequencing of drug-resistant viruses revealed mutations predicted to be on the periphery of the highly conserved viral RNA polymerase large subunit. Consistent with this, the compound had broad-spectrum activity against orthopoxviruses in vitro. These findings indicate that novel chemical synthesis approaches are a potential source for new infectious disease therapeutics and identify a potentially promising candidate for development to treat orthopoxvirus-infected individuals. C1 [Dower, Ken; Filone, Claire Marie; Hodges, Erin N.; Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Brown, Lauren E.; Schaus, Scott] Boston Univ, Sch Med, Dept Chem, Boston, MA 02118 USA. [Rubins, Kathleen H.] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA. [Filone, Claire Marie; Bjornson, Zach B.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Bjornson, Zach B.] Harvard Univ, Cambridge, MA 02138 USA. RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. EM jhconnor@bu.edu OI Connor, John/0000-0002-8867-7256; Filone, Claire Marie/0000-0002-4041-3948 FU Postgraduate Research Participation Program; U. S. Army Research and Medical Command; NIH [P41 GM086180] FX K.D. and C.M.F. were supported by the Postgraduate Research Participation Program and the U. S. Army Research and Medical Command administered by the Oak Ridge Institute for Science and Education (ORISE). S.S. acknowledges funding from the NIH (P41 GM086180). NR 33 TC 8 Z9 8 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 2012 VL 86 IS 5 BP 2632 EP 2640 DI 10.1128/JVI.05416-11 PG 9 WC Virology SC Virology GA 896AC UT WOS:000300536800021 PM 22205744 ER PT J AU Olal, D Kuehne, AI Bale, S Halfmann, P Hashiguchi, T Fusco, ML Lee, JE King, LB Kawaoka, Y Dye, JM Saphire, EO AF Olal, Daniel Kuehne, Ana I. Bale, Shridhar Halfmann, Peter Hashiguchi, Takao Fusco, Marnie L. Lee, Jeffrey E. King, Liam B. Kawaoka, Yoshihiro Dye, John M., Jr. Saphire, Erica Ollmann TI Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus SO JOURNAL OF VIROLOGY LA English DT Article ID CRYSTALLOGRAPHIC STRUCTURE DETERMINATION; NIEMANN-PICK C1; STRUCTURE VALIDATION; GLYCOPROTEIN; INFECTION; PHENIX; HIV-1; CONFORMATIONS; PROTEOLYSIS; MOLPROBITY AB Antibody 14G7 is protective against lethal Ebola virus challenge and recognizes a distinct linear epitope in the prominent mucin-like domain of the Ebola virus glycoprotein GP. The structure of 14G7 in complex with its linear peptide epitope has now been determined to 2.8 angstrom. The structure shows that this GP sequence forms a tandem beta-hairpin structure that binds deeply into a cleft in the antibody-combining site. A key threonine at the apex of one turn is critical for antibody interaction and is conserved among all Ebola viruses. This work provides further insight into the mechanism of protection by antibodies that target the protruding, highly accessible mucin-like domain of Ebola virus and the structural framework for understanding and characterizing candidate immunotherapeutics. C1 [Olal, Daniel; Bale, Shridhar; Hashiguchi, Takao; Fusco, Marnie L.; Lee, Jeffrey E.; King, Liam B.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Olal, Daniel] Free Univ Berlin, Berlin, Germany. [Kuehne, Ana I.; Dye, John M., Jr.] USA, Res Inst Infect Dis, Frederick, MD USA. [Halfmann, Peter; Kawaoka, Yoshihiro] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA. [Kawaoka, Yoshihiro] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Special Pathogens, Tokyo, Japan. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. RP Saphire, EO (reprint author), Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. EM erica@scripps.edu RI Ghartouchent, malek/B-9088-2012 FU NIAID [R01 AI 067927]; Skaggs Institute for Chemical Biology; Canadian Institutes for Health Research; NIAID/NIH; National Institutes of Health (NIH) [R01 AI055519]; Region V 'Great Lakes' Regional Center for Excellence for Biodefense and Emerging Infectious Disease Research (RCE) (NIH) [U54 AI057153]; DTRA [K.K0001_07_RD_B] FX We acknowledge support of NIAID R01 AI 067927 (E.O.S.), the Skaggs Institute for Chemical Biology (E.O.S.), Canadian Institutes for Health Research Postdoctoral Fellowship (J.E.L.), K99 Pathway to Independence from NIAID/NIH (J.E.L.), National Institutes of Health (NIH) R01 AI055519 and membership within and support from the Region V 'Great Lakes' Regional Center for Excellence for Biodefense and Emerging Infectious Disease Research (RCE) Program (NIH award U54 AI057153) (Y.K.), and DTRA K.K0001_07_RD_B (J.M.D.). NR 38 TC 19 Z9 19 U1 1 U2 17 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 2012 VL 86 IS 5 BP 2809 EP 2816 DI 10.1128/JVI.05549-11 PG 8 WC Virology SC Virology GA 896AC UT WOS:000300536800038 PM 22171276 ER PT J AU Misasi, J Chandran, K Yang, JY Considine, B Filone, CM Cote, M Sullivan, N Fabozzi, G Hensley, L Cunningham, J AF Misasi, John Chandran, Kartik Yang, Jin-Yi Considine, Bryden Filone, Claire Marie Cote, Marceline Sullivan, Nancy Fabozzi, Giulia Hensley, Lisa Cunningham, James TI Filoviruses Require Endosomal Cysteine Proteases for Entry but Exhibit Distinct Protease Preferences SO JOURNAL OF VIROLOGY LA English DT Article ID EBOLA-VIRUS GLYCOPROTEIN; HUMAN-IMMUNODEFICIENCY-VIRUS; LAKE-VICTORIA-MARBURGVIRUS; LECTINS DC-SIGN; NIEMANN-PICK C1; ZAIRE-EBOLAVIRUS; VIRAL ENTRY; HEMORRHAGIC-FEVER; CRYSTAL-STRUCTURE; BINDING AB Filoviruses are enveloped viruses that cause sporadic outbreaks of severe hemorrhagic fever [CDC, MMWR Morb. Mortal. Wkly. Rep. 50:73-77, 2001; Colebunders and Borchert, J. Infect. 40: 16 -20, 2000; Colebunders et al., J. Infect. Dis. 196(Suppl. 2):S148-S153, 2007; Geisbert and Jahrling, Nat. Med. 10:S110-S121, 2004]. Previous studies revealed that endosomal cysteine proteases are host factors for ebolavirus Zaire (Chandran et al., Science 308:1643-1645, 2005; Schornberg et al., J. Virol. 80:4174-4178, 2006). In this report, we show that infection mediated by glycoproteins from other phylogenetically diverse filoviruses are also dependent on these proteases and provide additional evidence indicating that they cleave GP1 and expose the binding domain for the critical host factor Niemann-Pick C1. Using selective inhibitors and knockout-derived cell lines, we show that the ebolaviruses Zaire and Cote d'Ivoire are strongly dependent on cathepsin B, while the ebolaviruses Sudan and Reston and Marburg virus are not. Taking advantage of previous studies of cathepsin B inhibitor-resistant viruses (Wong et al., J. Virol. 84:163-175, 2010), we found that virus-specific differences in the requirement for cathepsin B are correlated with sequence polymorphisms at residues 47 in GP1 and 584 in GP2. We applied these findings to the analysis of additional ebolavirus isolates and correctly predicted that the newly identified ebolavirus species Bundibugyo, containing D47 and I584, is cathepsin B dependent and that ebolavirus Zaire-1995, the single known isolate of ebolavirus Zaire that lacks D47, is not. We also obtained evidence for virus-specific differences in the role of cathepsin L, including cooperation with cathepsin B. These studies strongly suggest that the use of endosomal cysteine proteases as host factors for entry is a general property of members of the family Filoviridae. C1 [Misasi, John; Chandran, Kartik; Yang, Jin-Yi; Considine, Bryden; Filone, Claire Marie; Cote, Marceline; Cunningham, James] Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA. [Misasi, John; Considine, Bryden] Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA. [Filone, Claire Marie; Hensley, Lisa] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Sullivan, Nancy; Fabozzi, Giulia] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. [Cunningham, James] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA USA. RP Cunningham, J (reprint author), Brigham & Womens Hosp, Dept Med, Div Hematol, Boston, MA 02115 USA. EM kartik.chandran@einstein.yu.edu; jcunningham@rics.bwh.harvard.edu OI Filone, Claire Marie/0000-0002-4041-3948 FU PIDS-Sanofi-Pasteur [K12-HD052896, 5K08AI079381]; New England Research Center of Excellence in Biodefense and Emerging Infectious Diseases (NERCE/BEID); U.S. Army Medical Research and Material Command; Fonds de la Recherche en Sante du Quebec; [U54 AI057159]; [R01 CA104266] FX This work was supported by grants U54 AI057159 and R01 CA104266 to J.C. and PIDS-Sanofi-Pasteur fellowship K12-HD052896 and 5K08AI079381 to J.M. K.C. was supported by a postdoctoral fellowship from the New England Research Center of Excellence in Biodefense and Emerging Infectious Diseases (NERCE/BEID). C.F. was supported by the Postgraduate Research Participation Program at the U.S. Army Medical Research and Material Command administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. M.C. was supported by the Fonds de la Recherche en Sante du Quebec. NR 46 TC 40 Z9 42 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 2012 VL 86 IS 6 BP 3284 EP 3292 DI 10.1128/JVI.06346-11 PG 9 WC Virology SC Virology GA 897GC UT WOS:000300634100036 PM 22238307 ER PT J AU Hill, OT Wahi, MM Carter, R Kay, AB Mckinnon, CJ Wallace, RF AF Hill, Owen T. Wahi, Monika M. Carter, Robert, III Kay, Ashley B. Mckinnon, Craig J. Wallace, Robert F. TI Rhabdomyolysis in the US Active Duty Army, 2004-2006 SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE MUSCULAR DISEASES; EPIDEMIOLOGY; MILITARY PERSONNEL; HEAT EXHAUSTION ID EXERTIONAL HEAT ILLNESS; SICKLE-CELL TRAIT; EARLY ADULTHOOD; RENAL-FAILURE; EXERCISE; SOLDIERS; RECRUITS; POSITION; INCREASE; INJURY AB HILL, O. T., M. M. WAHI, R. CARTER III, A. B. KAY, C. J. MCKINNON, and R. F. WALLACE. Rhabdomyolysis in the US Active Duty Army, 2004-2006. Med. Sci. Sports Exerc., Vol. 44, No. 3, pp. 442-449, 2012. Purpose: Rhabdomyolysis (RM) is a skeletal muscle disorder resulting in severe cellular injury caused by vigorous physical activity and other systemic etiologies. RM is associated with significant morbidity, such as acute renal failure, and can be fatal. RM that occurs in the US Active Duty Army (ADA) results in time lost from training, deployment, and combat. We sought to systemically describe the epidemiology of ADA clinical RM by quantifying RM in terms of absolute numbers, examine rate trends, and identify soldiers at elevated risk. Methods: We used data from the Total Army Injury and Health Outcomes Database to calculate yearly RM rates in the overall ADA, as well as adjusted RM rates within soldier subpopulations for 2003-2006. Results: During this period, the absolute numbers of clinically diagnosed ADA RM ranged between 382 and 419 cases per year. Annual rates were 7-8 per 10,000, which is 300%-400% higher than the estimated US civilian population (2 per 10,000). In soldiers with a history of a prior heat injury, RM rates climbed to 52-86 per 10,000, a 7- to 11-fold increase. Increased RM rates were seen in soldiers who are male, African American, younger, less educated, and with a shorter length of service. Approximately 8% of yearly ADA RM cases resulted in acute renal failure, an estimate lower than that for the US civilian population. Conclusions: Our findings suggest that rates of RM are higher in the ADA than in the US civilian population. Rates remained fairly stable; however, relative to other ADA soldiers, those with prior heat injury, who are African American, or who have a length of service of less than 90 d are at the highest risk for RM development. C1 [Wahi, Monika M.] USA, Environm Med Res Inst, Attn MCMR EMP, Natick, MA 01760 USA. [Carter, Robert, III] USA, Med Res & Mat Command, Ft Detrick, MD USA. [Kay, Ashley B.] Social Sect Dev Strategies Inc, Boston, MA USA. RP Wahi, MM (reprint author), USA, Environm Med Res Inst, Attn MCMR EMP, Kansas St,Bldg 42, Natick, MA 01760 USA. EM monika.wahi@us.army.mil RI Hill, Owen/E-3643-2013 FU Military Operational Medicine Research Program; US Army Research Institute of Environmental Medicine FX This study was internally funded through the Military Operational Medicine Research Program.; This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Research Institute of Environmental Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the US Department of Energy and USAMRMC. NR 39 TC 11 Z9 11 U1 3 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 2012 VL 44 IS 3 BP 442 EP 449 DI 10.1249/MSS.0b013e3182312745 PG 8 WC Sport Sciences SC Sport Sciences GA 897HR UT WOS:000300639500011 PM 21857374 ER PT J AU Gortmaker, SL Lee, RM Mozaffarian, RS Sobol, AM Nelson, TF Roth, BA Wiecha, JL AF Gortmaker, Steven L. Lee, Rebekka M. Mozaffarian, Rebecca S. Sobol, Arthur M. Nelson, Toben F. Roth, Barbara A. Wiecha, Jean L. TI Effect of an After-School Intervention on Increases in Children's Physical Activity SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE MODERATE AND VIGOROUS PHYSICAL ACTIVITY; INTERVENTION; CHILD; ACCELEROMETER ID US CHILDREN; HEALTH-PROMOTION; FITNESS; ACCELEROMETER; ADOLESCENTS; PREVALENCE; PROGRAMS; IMPACT; GIRLS AB GORTMAKER, S. L., R. M. LEE, R. S. MOZAFFARIAN, A. M. SOBOL, T. F. NELSON, B. A. ROTH, and J. L. WIECHA. Effect of an After-School Intervention on Increases in Children's Physical Activity. Med. Sci. Sports Exerc., Vol. 44, No. 3, pp. 450-457, 2012. Purpose: Evaluate the effect of an after-school intervention on physical activity program changes and individual behaviors among children. Methods: A quasi-experimental evaluation of a YMCA-driven environmental change intervention with 16 intervention and 16 control sites in four metropolitan areas in the United States. Intervention sites participated in learning collaboratives designed to promote physical activity and nutrition through environmental change, educational activities, and parent engagement. Behavioral foci included increasing overall physical activity levels as well as combined moderate and vigorous physical activity and vigorous physical activity. Outcomes were assessed longitudinally using preintervention and follow-up surveys of program implementation and accelerometer measures of physical activity. ActiGraph accelerometer data were collected from a sample of 212 children, ages 5-11 yr, attending the programs. On average, 3 d of data were gathered per child. Reliability of the accelerometer counts averaged 0.78. Multivariate regression models were used to control for potential confounding variables and to account for clustering of observations. Results: Data indicate greater physical activity increases in children in intervention versus control sites after modest intervention implementation. Controlling for baseline covariates, children in intervention sites showed greater increases in average physical activity level than in control sites (76 counts per minute, P = 0.037, 95% confidence interval (CI) = 8.1-144) and more minutes of moderate and vigorous physical activity (10.5 min.d(-1), P = 0.017, 95% CI = 1.5-18.6), minutes of moderate physical activity (5.6 min.d(-1), P = 0.020, 95% CI = 0.99-10.2), and minutes of vigorous physical activity (5.1 min.d(-1), P = 0.051, 95% CI = 0.21-9.93). Conclusions: Results indicate significant increases in daily physical activity among children in intervention versus control sites. This study documents the effectiveness of an environmental change approach in an applied setting. C1 [Gortmaker, Steven L.; Lee, Rebekka M.; Mozaffarian, Rebecca S.; Sobol, Arthur M.] Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, Boston, MA 02115 USA. [Nelson, Toben F.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA. [Roth, Barbara A.] USA, YMCA, Chicago, IL USA. [Wiecha, Jean L.] Univ Massachusetts, Coll Nursing & Hlth Sci, Dept Exercise & Hlth Sci, Boston, MA 02125 USA. RP Gortmaker, SL (reprint author), Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, 677 Huntington Ave, Boston, MA 02115 USA. EM sgortmak@hsph.harvard.edu RI Schmoelz, Camilie/D-1707-2012; OI Schmoelz, Camilie/0000-0003-2221-9954; Nelson, Toben/0000-0001-9934-7546 FU Donald and Sue Pritzker Nutrition and Fitness Initiative, Centers for Disease Control and Prevention (Prevention Research Center) [U48DP001946, U48DP000064] FX The authors also thank an anonymous reviewer for input on the calculation of the daily energy expenditure estimates. Evaluation work was supported by the Donald and Sue Pritzker Nutrition and Fitness Initiative, Centers for Disease Control and Prevention (Prevention Research Center grants U48DP001946 and U48DP000064). NR 40 TC 38 Z9 39 U1 1 U2 53 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAR PY 2012 VL 44 IS 3 BP 450 EP 457 DI 10.1249/MSS.0b013e3182300128 PG 8 WC Sport Sciences SC Sport Sciences GA 897HR UT WOS:000300639500012 PM 21814151 ER PT J AU Kenney, K Landau, ME Gonzalez, RS Hundertmark, J O'Brien, K Campbell, WW AF Kenney, Kimbra Landau, Mark E. Gonzalez, Rodney S. Hundertmark, Julie O'Brien, Karen Campbell, William W. TI Serum creatine kinase after exercise: Drawing the line between physiological response and exertional rhabdomyolysis SO MUSCLE & NERVE LA English DT Article DE creatine kinase; exercise physiology; exertional rhabdomyolysis; military recruits; muscle; myoglobinuria; myopathy; rhabdomyolysis ID MUSCLE DAMAGE; GENOTYPE; ACTN3 AB Introduction: In this investigation we assessed the spectrum of creatine kinase (CK) responses in military recruits undergoing basic training. Methods: Musculoskeletal examination data, questionnaire findings, and CK levels were obtained from 499 recruits at days 0, 3, 7, and 14 of training. Correlations of CK with ethnicity, age, body mass index, exercise, muscle pain, and climate were obtained. Results: None of the subjects developed clinical exertional rhabdomyolysis (ER). The mean/median serum CK values were 223/157, 734/478, 1226/567, and 667/486 IU/L at days 0, 3, 7, and 14, respectively, with a wide overall range (3435,056 IU/L). African-American subjects had higher mean CK levels. Conclusions: CK elevations and muscle pain are common during basic training. Widely accepted laboratory diagnostic values for ER are routinely exceeded in this military recruits, suggesting that CK levels >50 times the upper limit of normal are more specific. The findings support using CK as a marker for ER. Normal laboratory reference ranges for CK should be published by ethnicity. Muscle Nerve, 2012 C1 [Kenney, Kimbra; Landau, Mark E.; Campbell, William W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Gonzalez, Rodney S.; Hundertmark, Julie] Martin Army Community Hosp, Dept Family Med, Ft Benning, GA USA. [O'Brien, Karen] USA, Training & Doctrine Command TRADOC, Ft Monroe, VA USA. RP Kenney, K (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM kkenney@usuhs.mil FU Uniformed Services University of Health Sciences, Bethesda, Maryland FX This study was supported by the Comprehensive National Neuroscience Program (CNNP) at the Uniformed Services University of Health Sciences, Bethesda, Maryland. NR 17 TC 30 Z9 32 U1 0 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0148-639X J9 MUSCLE NERVE JI Muscle Nerve PD MAR PY 2012 VL 45 IS 3 BP 356 EP 362 DI 10.1002/mus.22317 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 897UT UT WOS:000300684600006 PM 22334169 ER PT J AU Trost, Z Vangronsveld, K Linton, SJ Quartana, PJ Sullivan, MJL AF Trost, Zina Vangronsveld, Karoline Linton, Steven J. Quartana, Phillip J. Sullivan, Michael J. L. TI Cognitive dimensions of anger in chronic pain SO PAIN LA English DT Review ID ATTRIBUTIONS; DIRECTIONS; EXPRESSION; ADJUSTMENT; ATTENTION; SAMPLE; BLAME; MODEL; STYLE C1 [Trost, Zina; Sullivan, Michael J. L.] McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada. [Vangronsveld, Karoline] Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium. [Linton, Steven J.] Univ Orebro, Ctr Hlth & Med Psychol, Orebro, Sweden. [Quartana, Phillip J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Trost, Z (reprint author), McGill Univ, Dept Psychol, 1205 Dr Penfield Ave, Montreal, PQ H3A 1B1, Canada. EM zinaidat@gmail.com NR 40 TC 23 Z9 23 U1 1 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD MAR PY 2012 VL 153 IS 3 BP 515 EP 517 DI 10.1016/j.pain.2011.10.023 PG 3 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA 897BR UT WOS:000300616600006 PM 22136750 ER PT J AU Yokota, M Berglund, LG Bathalon, GP AF Yokota, Miyo Berglund, Larry G. Bathalon, Gaston P. TI Female anthropometric variability and their effects on predicted thermoregulatory responses to work in the heat SO INTERNATIONAL JOURNAL OF BIOMETEOROLOGY LA English DT Article DE Anthropometry; Thermoregulatory model; Heat stress; Core temperature; Female ID ENERGY-EXPENDITURE; RISK-FACTORS; WALKING; STRESS; STRAIN; WOMEN AB The use of thermoregulatory models for assessing physiological responses of workers in thermally stressful situations has been increasing because of the risks and costs related to human studies. In a previous study (Yokota et al. Eur J Appl Physiol 104:297-302, 2008), the effects of anthropometric variability on predicted physiological responses to heat stress in U.S. Army male soldiers were evaluated. Five somatotypes were identified in U.S. Army male multivariate anthropometric distribution. The simulated heat responses, using a thermoregulatory model, were different between somatotypes. The present study further extends this line of research to female soldiers. Anthropometric somatotypes were identified using multivariate analysis [height, weight, percent body fat (%BF)] and the predicted physiological responses to simulated exercise and heat stress using a thermoregulatory model were evaluated. The simulated conditions included walking at similar to 3 mph (4.8 km/h) for 300 min and wearing battle dress uniform and body armor in a 30A degrees C, 25% relative humidity (RH) environment without solar radiation. Five major somatotypes (tall-fat, tall-lean, average, short-lean, and short-fat), identified through multivariate analysis of anthropometric distributions, showed different tolerance levels to simulated heat stress: lean women were predicted to maintain their core temperatures (T-c) lower than short-fat or tall-fat women. The measured T-c of female subjects obtained from two heat studies (data1: 30A degrees C, 32% RH, protective garments, similar to 225 w center dot m(-2) walk for 90 min; data2: 32A degrees C, 75% RH, hot weather battle dress uniform, similar to 378 A +/- 32 w center dot m(-2) for 30 min walk/30 min rest cycles for 120 min) were utilized for validation. Validation results agreed with the findings in this study: fat subjects tended to have higher core temperatures than medium individuals (data2) and lean subjects maintained lower core temperatures than medium subjects (data1). C1 [Yokota, Miyo] USA, Biophys & Biomed Modeling Div, Res Inst Environm Med USARIEM, Natick, MA 01760 USA. RP Yokota, M (reprint author), USA, Biophys & Biomed Modeling Div, Res Inst Environm Med USARIEM, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Miyo.Yokota@us.army.mil NR 25 TC 4 Z9 4 U1 0 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0020-7128 J9 INT J BIOMETEOROL JI Int. J. Biometeorol. PD MAR PY 2012 VL 56 IS 2 BP 379 EP 385 DI 10.1007/s00484-011-0441-6 PG 7 WC Biophysics; Environmental Sciences; Meteorology & Atmospheric Sciences; Physiology SC Biophysics; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences; Physiology GA 893HL UT WOS:000300346800017 PM 21573821 ER PT J AU Fresconi, F Cooper, G Celmins, I DeSpirito, J Costello, M AF Fresconi, F. Cooper, G. Celmins, I. DeSpirito, J. Costello, M. TI Flight mechanics of a novel guided spin-stabilized projectile concept SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART G-JOURNAL OF AEROSPACE ENGINEERING LA English DT Article DE precision munition; flight mechanics; flight control law; flight stability ID ATMOSPHERIC FLIGHT; CONTROL AUTHORITY; LINEAR-THEORY; PART AB Precision-guided munitions are of interest to the Army as a means of both reducing collateral damage and increasing the chance of desired effect with the first round fired. Many technical barriers must be overcome to effectively guide a gun-launched projectile. Gun tubes are rifled to impart the appropriate spin to gyroscopically stabilize a statically unstable projectile. Extremely high spin rates complicate the guidance problem for precision-guided munitions. Manoeuvres achieved through some control mechanism must be actuated at the projectile spin rate. Few control mechanisms have been developed for spin-stabilized projectiles. A novel manoeuvre concept is introduced in this effort. The effectiveness of this concept was investigated through a fundamental derivation of flight mechanics and aerodynamic modelling. This derivation and simulation implementation was verified with existing six degree-of-freedom methods. The manoeuvrability of the airframe and power requirements was assessed by the development of a flight control law. Results suggest sufficient manoeuvrability since the control authority is larger than the ballistic dispersion. The guided airframe exhibited no dynamic flight instabilities. Estimates of the power requirements were within current battery technology and size constraints. C1 [Fresconi, F.; Cooper, G.; Celmins, I.; DeSpirito, J.] USA, Res Lab, Aberdeen Proving Ground, MD 21015 USA. [Costello, M.] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. RP Fresconi, F (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21015 USA. EM frank.fresconi@arl.army.mil NR 16 TC 6 Z9 7 U1 3 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0954-4100 J9 P I MECH ENG G-J AER JI Proc. Inst. Mech. Eng. Part G-J. Aerosp. Eng. PD MAR PY 2012 VL 226 IS G3 BP 327 EP 340 DI 10.1177/0954410011408385 PG 14 WC Engineering, Aerospace; Engineering, Mechanical SC Engineering GA 894VW UT WOS:000300456400007 ER PT J AU Dong, H Strawhecker, KE Snyder, JF Orlicki, JA Reiner, RS Rudie, AW AF Dong, Hong Strawhecker, Kenneth E. Snyder, James F. Orlicki, Joshua A. Reiner, Richard S. Rudie, Alan W. TI Cellulose nanocrystals as a reinforcing material for electrospun poly(methyl methacrylate) fibers: Formation, properties and nanomechanical characterization SO CARBOHYDRATE POLYMERS LA English DT Article DE Cellulose nanocrystals; Nano-DMA; Nanoindentation Poly(methyl methacrylate) fibers; Electrospinning; Thermal properties ID ATOMIC-FORCE MICROSCOPY; CARBON NANOTUBES; ORGANIC-SOLVENTS; NANOFIBERS; NANOCOMPOSITES; NANOINDENTATION; FABRICATION; COMPOSITES; WHISKERS; NYLON-6 AB Uniform fibers composed of poly(methyl methacrylate) (PMMA) reinforced with progressively increasing contents of cellulose nanocrystals (CNCs), up to 41 wt%CNCs, have been successfully produced by electrospinning. The morphological, thermal and nanomechanical properties of the composite sub-micron fibers were investigated. The CNCs derived from wood pulp by sulfuric acid hydrolysis were well dispersed in solutions of PMMA and the processing solvent N,N-dimethylformamide prior to fiber formation. Well-formed fibers with controllable diameters were generated reproducibly at all CNC contents investigated including 41 wt%. The orientation of the CNCs along the fiber axis was facilitated by the electrospinning process and observed directly from microscopy examination. Shifts in thermal transitions of PMMA with increasing CNC content suggest hydrogen bonding interactions between CNC hydroxyl groups and carbonyl groups on the PMMA matrix. Nanoscale dynamic mechanical analysis (nano-DMA) was performed using nanoindentation on single fibers perpendicular to the fiber axis. Many of the current challenges associated with single fiber nanoindentation are addressed, such as fiber diameter range and minimum. depth to diameter ratio, and valid depth range under these experimental conditions. Fibers that contained 17 wt% CNCs showed a modest increase of 17% in the storage modulus of PMMA, a high modulus polymer of interest for transparent composite applications. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Dong, Hong; Strawhecker, Kenneth E.; Snyder, James F.; Orlicki, Joshua A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Reiner, Richard S.; Rudie, Alan W.] US Forest Serv, USDA, Forest Prod Lab, Madison, WI 53726 USA. RP Dong, H (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM hong.dong.ctr@mail.mil FU U.S. Army Research Laboratory FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. The authors would like to acknowledge Dr. M.R.VanLandingham for insight and discussion on Nano-DMA work. NR 38 TC 59 Z9 64 U1 8 U2 111 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0144-8617 EI 1879-1344 J9 CARBOHYD POLYM JI Carbohydr. Polym. PD MAR 1 PY 2012 VL 87 IS 4 BP 2488 EP 2495 DI 10.1016/j.carbpol.2011.11.015 PG 8 WC Chemistry, Applied; Chemistry, Organic; Polymer Science SC Chemistry; Polymer Science GA 887YA UT WOS:000299969800017 ER PT J AU DeCostanza, AH DiRosa, GA Rogers, SE Slaughter, AJ Estrada, AX AF DeCostanza, Arwen H. DiRosa, Gia A. Rogers, Sean E. Slaughter, Andrew J. Estrada, Armando X. TI Researching Teams: Nothing's Going to Change Our World SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND PRACTICE LA English DT Editorial Material C1 [DeCostanza, Arwen H.; DiRosa, Gia A.; Slaughter, Andrew J.; Estrada, Armando X.] USA, Res Inst Behav & Social Sci, Aberdeen Proving Ground, MD 21005 USA. [Rogers, Sean E.] Rutgers State Univ, Piscataway, NJ 08855 USA. RP DeCostanza, AH (reprint author), USA, Res Inst, DAPE, ARI,FS, 6010 Frankford St,Off 221A, Aberdeen Proving Ground, MD 21005 USA. EM arwen.h.decostanza@us.army.mil NR 6 TC 2 Z9 2 U1 1 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1754-9426 EI 1754-9434 J9 IND ORGAN PSYCHOL-US JI Ind. Organ. Psychol. PD MAR PY 2012 VL 5 IS 1 BP 36 EP U158 DI 10.1111/j.1754-9434.2011.01400.x PG 4 WC Psychology, Applied SC Psychology GA 886CT UT WOS:000299829700006 ER PT J AU Bellan, LM Kniazeva, T Kim, ES Epshteyn, AA Cropek, DM Langer, R Borenstein, JT AF Bellan, Leon M. Kniazeva, Tatiana Kim, Ernest S. Epshteyn, Alla A. Cropek, Donald M. Langer, Robert Borenstein, Jeffrey T. TI Fabrication of a Hybrid Microfluidic System Incorporating both Lithographically Patterned Microchannels and a 3D Fiber-Formed Microfluidic Network SO ADVANCED HEALTHCARE MATERIALS LA English DT Article ID MICROVASCULAR NETWORKS; VASCULAR-RESISTANCE; SCAFFOLDS; LAYERS; FLAPS C1 [Bellan, Leon M.; Langer, Robert] MIT, David H Koch Inst, Cambridge, MA 02139 USA. [Cropek, Donald M.] US Army Corps Engn, Construct Engn Res Lab, Champaign, IL 61822 USA. [Kniazeva, Tatiana; Kim, Ernest S.; Epshteyn, Alla A.; Borenstein, Jeffrey T.] Draper Lab, Ctr Biomed Engn, Cambridge, MA 02139 USA. RP Bellan, LM (reprint author), MIT, David H Koch Inst, 77 Massachusetts Ave,Room 76-661, Cambridge, MA 02139 USA. EM Lbellan@mit.edu FU U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL); NIH [5F32EB011866, 1K99EB013630]; NIH NHLBI [1 R21 HL106585-01]; National Science Foundation under NSF [ECS-0335765] FX The authors thank Eliza Vasile for help with the Volocity software, and Heather Clark and James Hsiao for help with confocal imaging. This research was supported in part by the U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL). One of the authors, LMB, gratefully acknowledges support from NIH grants 5F32EB011866 and 1K99EB013630. Another author, JTB, acknowledges support for this research from NIH NHLBI grant 1 R21 HL106585-01. This work was performed in part at the Center for Nanoscale Systems (CNS), a member of the National Nanotechnology Infrastructure Network (NNIN), which is supported by the National Science Foundation under NSF award no. ECS-0335765. CNS is part of Harvard University. NR 20 TC 17 Z9 17 U1 3 U2 44 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2192-2640 J9 ADV HEALTHC MATER JI Adv. Healthc. Mater. PD MAR PY 2012 VL 1 IS 2 BP 164 EP 167 DI 10.1002/adhm.201100052 PG 4 WC Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials SC Engineering; Science & Technology - Other Topics; Materials Science GA 092HN UT WOS:000315111100004 PM 22708076 ER PT J AU Srinivasan, S Yehuda, R Scalmati, A Ahmed, I Kirwin, P AF Srinivasan, Shilpa Yehuda, Rachel Scalmati, Alessandra Ahmed, Iqbal Kirwin, Paul TI PROXIMAL AND LATENT EFFECTS OF DISASTERS IN ELDERLY: FROM NEUROIMMUNOLOGY TO JAPAN 2012 SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY LA English DT Meeting Abstract CT Annual Meeting of American-Association-for-Geriatric-Psychiatry CY MAR 16-19, 2012 CL Washington, DC C1 [Srinivasan, Shilpa] Univ South Carolina, Sch Med, Columbia, SC USA. [Yehuda, Rachel] Mt Sinai Sch Med, New York, NY USA. [Scalmati, Alessandra] Montefiore Med Ctr, New York, NY USA. [Ahmed, Iqbal] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Kirwin, Paul] Yale Med Sch, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1064-7481 EI 1545-7214 J9 AM J GERIAT PSYCHIAT JI Am. J. Geriatr. Psychiatr. PD MAR PY 2012 VL 20 IS 3 SU 1 MA 105 BP S11 EP S11 PG 1 WC Geriatrics & Gerontology; Gerontology; Psychiatry SC Geriatrics & Gerontology; Psychiatry GA V45WK UT WOS:000209846500006 ER PT J AU Edmonds, JM Collett, PJ Brown, RL Mangaya, K AF Edmonds, Jason M. Collett, Patricia J. Brown, Rebecca L. Mangaya, Kishna TI Surface Sampling of a Dry Aerosol Deposited Ricin SO APPLIED SCIENCES-BASEL LA English DT Article DE surface sampling; recovery efficiency; bioterrorism; detection; ricin; toxin AB Sampling of small molecules from both porous and non-porous surfaces poses a significant challenge across biological agents. Particle sizes of toxins are smaller than living organisms and can be extremely toxic at low level concentrations. A small number of studies evaluating sampling efficiencies of commercial off the shelf (COTS) materials have been performed with toxins and proteins. However, they have been limited to non-ricin stimulants with drastically different physical properties than their native counterparts. We have identified a commercially available non-toxic recombinant ricin, complete with both A and B subunits present, which can be recognized by antibodies commonly used to assay native ricin. In evaluating recovery efficiency, we deposited the recombinant ricin by both liquid deposition, and as a dry aerosol. Our studies demonstrated a significant difference in recovery efficiencies from liquid deposited ricin, ranging between 30% and 70%, than from an aerosol generated deposition ranging from below detectable levels to 22%, depending on the contaminated surface and swab material being used. This study demonstrates the necessity for accurate dissemination techniques of sampling technologies for the consideration of use in an environment where suspected toxin contamination is being evaluated. C1 [Edmonds, Jason M.; Collett, Patricia J.; Brown, Rebecca L.] US Army, Edgewood Chem Biol Ctr, Dept Def, Aberdeen Proving Ground, MD 21010 USA. [Mangaya, Kishna] Sci Applicat Int Corp, Mclean, VA 22102 USA. RP Edmonds, JM (reprint author), US Army, Edgewood Chem Biol Ctr, Dept Def, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM jason.edmonds1@us.army.mil; patricia.collett@us.army.mil; rebecca.l.brown160.civ@mail.mil; kishna.mangaya.ctr@mail.mil FU Defense Threat Reduction Agency, DTRA [HD07DET313, B072137M] FX Funding for this program was provided by the Defense Threat Reduction Agency, DTRA Project ID# HD07DET313 Contract# B072137M. NR 16 TC 1 Z9 1 U1 0 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2076-3417 J9 APPL SCI-BASEL JI Appl. Sci.-Basel PD MAR PY 2012 VL 2 IS 1 BP 13 EP 23 DI 10.3390/app2010013 PG 11 WC Chemistry, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Materials Science; Physics GA V36XJ UT WOS:000209240700002 ER PT J AU Sloop, JC Boyle, PD Fountain, AW Gomez, C Jackson, JL Pearman, WF Schmidt, RD Weyand, J AF Sloop, Joseph C. Boyle, Paul D. Fountain, Augustus W. Gomez, Cristina Jackson, James L. Pearman, William F. Schmidt, Robert D. Weyand, Jonathan TI Novel Fluorinated Indanone, Tetralone and Naphthone Derivatives: Synthesis and Unique Structural Features SO APPLIED SCIENCES-BASEL LA English DT Article DE 2-trifluoroacetyl-1,3-Diketone; 1,3,5-triketone; tautomerism; X-ray crystallography AB Several fluorinated and trifluoromethylated indanone, tetralone and naphthone derivatives have been prepared via Claisen condensations and selective fluorinations in yields ranging from 22-60%. In addition, we report the synthesis of new, selectively fluorinated bindones in yields ranging from 72-92%. Of particular interest is the fluorination and trifluoroacetylation regiochemistry observed in these fluorinated products. We also note unusual transformations including a novel one pot, dual trifluoroacetylation, trifluoroacetylnaphthone synthesis via a deacetylation as well as an acetyl-trifluoroacetyl group exchange. Solid-state structural features exhibited by these compounds were investigated using crystallographic methods. Crystallographic results, supported by spectroscopic data, show that trifluoroacetylated ketones prefer a chelated cis-enol form whereas fluorinated bindone products exist primarily as the cross-conjugated triketo form. C1 [Sloop, Joseph C.] Georgia Gwinnett Coll, Sch Sci & Technol, Lawrenceville, GA 30043 USA. [Boyle, Paul D.; Schmidt, Robert D.] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA. [Fountain, Augustus W.] Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Gomez, Cristina; Pearman, William F.; Weyand, Jonathan] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Jackson, James L.] US Army Corps Engineers, Savannah, GA 31401 USA. RP Sloop, JC (reprint author), Georgia Gwinnett Coll, Sch Sci & Technol, 1000 Univ Ctr Lane, Lawrenceville, GA 30043 USA. EM jsloop@ggc.edu; boyle@ncsu.edu; augustus.w.fountain@us.army.mil; cristina.c.gomez@us.army.mil; James.L.Jackson@usace.army.mil; William.Pearman@usma.edu; rdschmid@ncsu.edu; jon.weyand@us.army.mil OI Sloop, Joseph/0000-0001-7639-0234 FU Department of Chemistry of NCSU; State of North Carolina; USMA [CLS-02-07]; GGC SST Faculty Research Funds FX The views expressed in this academic research paper are those of the authors and do not necessarily reflect the official policy or position of the US Government, the Department of Defense, or any of its agencies. The authors wish to thank the NCSU X-ray Facility for crystallographic support and NCSU Mass Spectrometry Facility for high resolution mass spectroscopic support of this work. The authors also wish to thank the Department of Chemistry of NCSU and the State of North Carolina for funding the purchase of the Apex2 diffractometer. Joseph C. Sloop thanks the USMA (C&LS-02-07) and GGC SST Faculty Research Funds for providing financial support for this work. NR 34 TC 1 Z9 1 U1 1 U2 1 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2076-3417 J9 APPL SCI-BASEL JI Appl. Sci.-Basel PD MAR PY 2012 VL 2 IS 1 BP 61 EP 99 DI 10.3390/app2010061 PG 39 WC Chemistry, Multidisciplinary; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Materials Science; Physics GA V36XJ UT WOS:000209240700005 ER PT J AU Whipple, SD Lindroth, EJ Hoback, WW Albrecht, MC Foster, JE AF Whipple, Sean D. Lindroth, Erica J. Hoback, W. Wyatt Albrecht, Marc C. Foster, John E. TI GENETIC VARIABILITY OF DIGITONTHOPHAGUS GAZELLA (F.) (COLEOPTERA: SCARABAEIDAE) FROM VIEQUES, PUERTO RICO AND SOUTH AFRICA SO COLEOPTERISTS BULLETIN LA English DT Article DE AFLP; dung beetle; gene flow; population genetics ID DUNG BEETLE; CALLIPHORIDAE; DIPTERA; RECORDS; LARVAE AB Digitonthophagus gazella (F.) has been widely introduced to the New World and both natural dispersal and intentional releases continue. In this study, we compare a population of D. gazelle from South Africa and from the island of Vieques, Puerto Rico, using amplified fragment length polymorphism (AFLP) analysis. Genetic diversity was found to be high in both South Africa (H = 0.3623) and Vieques (H = 0.3846), providing no evidence of inbreeding depression on Vieques. Analysis of molecular variance (AMOVA) revealed that 69% of genetic diversity is within the populations and 31% of genetic diversity is between the populations, indicating that if interbreeding occurs between these populations, it is rare and likely human-mediated. The Fat value of 0.3143 also suggests that there is genetic isolation between populations in Africa and newly established populations in the New World. Because of its competitiveness and natural dispersal ability, additional comparisons of D. gazella populations, biology, and genetics are warranted. C1 [Whipple, Sean D.; Foster, John E.] Univ Nebraska, Dept Entomol, Lincoln, NE 68583 USA. [Lindroth, Erica J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Hoback, W. Wyatt; Albrecht, Marc C.] Univ Nebraska, Dept Biol, Kearney, NE 68849 USA. RP Whipple, SD (reprint author), Univ Nebraska, Dept Entomol, Lincoln, NE 68583 USA. NR 42 TC 1 Z9 1 U1 1 U2 4 PU COLEOPTERISTS SOC PI ATHENS PA UNIV GEORGIA, 413 BIOLOGICAL SCIENCES BUILDING, ATHENS, GA 30602-2603 USA SN 0010-065X EI 1938-4394 J9 COLEOPTS BULL JI Coleopt. Bull. PD MAR PY 2012 VL 66 IS 1 BP 45 EP 50 PG 6 WC Entomology SC Entomology GA 142UE UT WOS:000318822300008 ER PT J AU Napolitano, MP AF Napolitano, Marc Philip TI SINGING CHRISTMAS CAROLS : THE DICKENSIAN MUSICAL VS. THE DICKENSIAN MEGA-MUSICAL SO ENGLISH LA English DT Article AB Adaptation theorist Thomas Leitch has studied the various children's films based on Dickens's A Christmas Carol as potential 'entryways' into the Dickens canon, drawing particular attention to the potential for musical adaptations to captivate young viewers while capturing the unbridled emotionalism of Dickens through the spectacle of song. There are many different musical genres, several of which are associated with specific cultures: the integrated 'book musical', which seamlessly incorporates songs into the narrative, is associated primarily with American musical theatre, while the operatic 'mega-musical' is a European variation on the American form. Leslie Bricusse's Scrooge (1970) and Alan Menken's A Christmas Carol: The Musical (1994) are especially important examples to consider in this context, as contrasting these two musical variations of the Dickensian source allows for a clearer understanding of what these different musical genres can and cannot achieve. Bricusse's adaptation employs the conventions of the American integrated musical despite the fact that Bricusse is English, while Menken's adaptation employs the conventions of the European mega-musical despite the fact that Menken is American. Ironically, it is by utilizing the American format of the book musical that Bricusse is able to emphasize the Englishness of his source, for the integrated format allows him to place specific emphasis on Dickens's characters and the traditional roots of the story. Menken's mega-musical approach sacrifices some of these traditional elements for the sake of a larger spectacle, reducing the Englishness of the adaptation but simultaneously allowing for a 'global' appreciation of the story's transcendent morals. C1 US Mil Acad, West Point, NY 10996 USA. RP Napolitano, MP (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 21 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0013-8215 J9 ENGLISH JI English PD SPR PY 2012 VL 61 IS 232 BP 66 EP 88 DI 10.1093/english/efs003 PG 23 WC Literature SC Literature GA 199PY UT WOS:000323008400008 ER PT J AU Bracken, JN Huffaker, RK Yandell, PM Handcock, T Higgins, EW Kuehl, TJ Shull, BL AF Bracken, Jessica N. Huffaker, R. Keith Yandell, Paul M. Handcock, Tyler Higgins, Edmund W. Kuehl, Thomas J. Shull, Bobby L. TI A Randomized Comparison of Bupivacaine Versus Saline During Placement of Tension-Free Vaginal Tape SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY LA English DT Article DE hydrodissection; tension-free vaginal tape; voiding trial AB Objectives: To compare postoperative urinary retention and pain control when bupivacaine versus saline for hydrodissection is used while placing tension-free vaginal tape midurethral slings. Methods: A prospective, randomized, double-blind trial was performed after institutional review board approval. Sixty women were randomized to receive bupivacaine or saline for hydrodissection. Subjects and research team were blinded to subject assignments. Group characteristics were compared using the Student t test, the chi(2) test, and the Mann-Whitney U test. Proportions of subjects with a successful postoperative voiding trial along with measurements of postoperative pain and analgesic use were compared using similar appropriate tests. The study was powered to detect differences in voiding trial success from an estimated 58% to greater than 90% with P < 0.05 and 0.8 power using 25 subjects per group. Results: Thirty patients were allocated to each group. One subject in the saline-only group was excluded. Group characteristics were not different. After surgery, pain medication use (20/30 vs 25/29 for bupivacaine vs saline only; P = 0.08), pain scores (36 +/- 22 vs 31 +/- 24; P = 0.49), and successful voiding trials did not differ (14/30 vs 19/29; P = 0.14), whereas postvoid residuals did differ (225 +/- 180 mL vs 140 +/- 147 mL; P = 0.043). Conclusions: Bupivacaine was not seen to improve immediate postoperative pain after placement of a tension-free vaginal tape. It did not increase the risk of failing a postoperative voiding trial. Without an obvious benefit, the use of an additional medicine is not supported. We suggest saline alone be used for hydrodissection. C1 [Bracken, Jessica N.; Yandell, Paul M.; Kuehl, Thomas J.; Shull, Bobby L.] Scott & White Healthcare, Dept Obstet & Gynecol, Temple, TX 76508 USA. [Bracken, Jessica N.; Yandell, Paul M.; Kuehl, Thomas J.; Shull, Bobby L.] Texas A&M Univ Syst Hlth Sci Ctr, Coll Med, Temple, TX USA. [Huffaker, R. Keith] E Tennessee State Univ, Quillen Coll Med, Dept Obstet & Gynecol, Quillen ETSU Pelv Surg & Urogynecol, Johnson City, TN 37614 USA. [Handcock, Tyler] Round Rock Scott & White Hosp & Clin, Dept Obstet & Gynecol, Round Rock, TX USA. [Higgins, Edmund W.] Womack Army Med Ctr, Dept Obstet & Gynecol, Div Urogynecol, Ft Bragg, NC USA. RP Kuehl, TJ (reprint author), Scott & White Healthcare, Dept Obstet & Gynecol, 2401 S 31st St, Temple, TX 76508 USA. EM tkuehl@swmail.sw.org FU Enderly Endowment for Research in Urogynecology; Noble Centennial Endowment FX Funding for this study was provided by the Enderly Endowment for Research in Urogynecology and the Noble Centennial Endowment (TJK). NR 20 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 2151-8378 J9 FEMALE PELVIC MED RE JI Female Pelvic Med. Reconstr. Surg. PD MAR-APR PY 2012 VL 18 IS 2 BP 93 EP 96 DI 10.1097/SPV.0b013e3182436655 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA V35XH UT WOS:000209178000007 PM 22453319 ER PT J AU Waterman, BR Belmont, PJ Owens, BD AF Waterman, Brian R. Belmont, Philip J., Jr. Owens, Brett D. TI Patellar Dislocation in the United States: Role of Sex, Age, Race, and Athletic Participation SO JOURNAL OF KNEE SURGERY LA English DT Article DE patella; dislocation; patellofemoral; instability; epidemiology AB Patellar instability has been extensively studied in selected, high-risk cohorts, but the epidemiology in the general population remains unclear. A longitudinal, prospective epidemiological database was used to determine the incidence and demographic risk factors for patellar dislocations presenting to emergency departments of the United States. The National Electronic Injury Surveillance System was queried for all patellar dislocations presenting to emergency departments between 2003 and 2008. Incidence rate ratios (IRRs) were then calculated with respect to sex, age, and race. The hypothesis was that patellar dislocation is influenced by sex, age, race, and athletic participation. An estimated 40,544 patellar dislocations occurred among an at-risk population of 1,774,210,081 person-years for an incidence rate of 2.29 per 100,000 person-years in the United States. When compared with males, females showed no significant overall or age-stratified differences in the rates of patellar dislocation (IRR 0.85, 95% CI 0.71, 1.00; p = 0.08; p > 0.05). Peak incidence of patellar dislocation occurred between 15 and 19 years of age (11.19/100,000 person-years). When compared with Hispanic race, black and white race were associated with significantly higher rates of patellar dislocation (IRR 4.30 [95% CI 1.63, 6.97; p = 0.02], IRR 4.02 [95% CI 1.06, 6.98; p = 0.03], respectively). Nearly half (51.9%) of all patellar dislocation occurred during athletic activity, with basketball (18.2%), soccer (6.9%), and football (6.3%) associated with the highest percentage of patellar dislocation during athletics. Age between 15 and 19 years is associated with higher rates of patellar dislocation. Sex is not a significant risk factor for patellar dislocation. Black and white race are a significant risk factor for patellar dislocation when compared with Hispanic race. Half of all patellar dislocation occurs during athletic activity. This study was conducted on the Level of evidence II. C1 [Waterman, Brian R.; Belmont, Philip J., Jr.] William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX 79920 USA. [Owens, Brett D.] Keller Army Hosp, West Point, NY USA. RP Waterman, BR (reprint author), William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, 5005 N Piedras St, El Paso, TX 79920 USA. EM brian.waterman@amedd.army.mil OI Belmont, Philip/0000-0003-2618-199X NR 46 TC 11 Z9 11 U1 1 U2 5 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 1538-8506 EI 1938-2480 J9 J KNEE SURG JI J. Knee Surg. PD MAR PY 2012 VL 25 IS 1 BP 51 EP 57 DI 10.1055/s-0031-1286199 PG 7 WC Orthopedics SC Orthopedics GA V35SD UT WOS:000209167600009 PM 22624248 ER PT J AU Forney, AJ AF Forney, Andrew J. TI DARK ROSE: Organized Crime and Corruption in Portland SO JOURNAL OF THE WEST LA English DT Book Review C1 [Forney, Andrew J.] US Mil Acad, West Point, NY 10996 USA. RP Forney, AJ (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ABC-CLIO PI SANTA BARBARA PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA SN 0022-5169 J9 J WEST JI J. West PD SPR PY 2012 VL 51 IS 2 BP 81 EP 82 PG 2 WC History SC History GA 183GE UT WOS:000321801700012 ER PT J AU Hill, MJ Chason, RJ Payson, MD Segars, JH Csokmay, JM AF Hill, Micah J. Chason, Rebecca J. Payson, Mark D. Segars, James H. Csokmay, John M. TI GnRH Antagonist Rescue Reduces Serum Estradiol in High Responders at Risk for OHSS While Maintaining Excellent ART Outcomes. SO REPRODUCTIVE SCIENCES LA English DT Meeting Abstract C1 [Hill, Micah J.; Chason, Rebecca J.; Payson, Mark D.; Csokmay, John M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Hill, Micah J.; Chason, Rebecca J.; Segars, James H.] NICHD, Program Reprod & Adult Endocrinol, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1933-7191 EI 1933-7205 J9 REPROD SCI JI Reprod. Sci. PD MAR PY 2012 VL 19 IS S3 SU 3 BP 282A EP 282A PG 1 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 287LP UT WOS:000329543602321 ER PT J AU Harrison, BA Ruiz-Lopez, F Falero, GC Savage, HM Pecor, JE Wilkerson, RC AF Harrison, Bruce A. Ruiz-Lopez, Freddy Falero, Guillermo Calderon Savage, Harry M. Pecor, James E. Wilkerson, Richard C. TI Anopheles (Kerteszia) lepidotus (Diptera: Culicidae), not the malaria vector we thought it was: Revised male and female morphology; larva, pupa, and male genitalia characters; and molecular verification SO ZOOTAXA LA English DT Article DE Anopheles lepidotus; Anopheles pholidotus; redescription; key; morphology; ITS2; COI; malaria ID INTERNAL TRANSCRIBED SPACER; PLASMODIUM-KNOWLESI; SUBGENUS KERTESZIA; SPECIES COMPLEX; CRUZII; DNA; POPULATIONS; PHYLOGENY; SEQUENCES; AMAZON AB The name Anopheles (Kerteszia) lepidotus Zavortink, commonly used for an important malaria vector in the eastern cordillera of the Andes, is here corrected to An. pholidotus Zavortink. We discovered that An. (Ker.) specimens from Peru, and reared-associated specimens from Ecuador, had unambiguous habitus characters that matched those on the male holotype of An. lepidotus. However, the specimens do not exhibit characters of the female allotype and female paratypes of An. lepidotus, which are actually An. pholidotus. Our specimens are the first correctly associated females of An. lepidotus, which allow us to provide a new morphological interpretation for the adult habitus of this species. This finding is also corroborated by molecular data from a portion of the Cytochrome Oxidase I (COI) gene and ribosomal DNA Internal Transcribed Spacer 2 (rDNA ITS2). The pupal stage of An. lepidotus is described for the first time, and additional larval characters are also noted. Diagnostic morphological characters for the adult, pupal, and larval stages of An. pholidotus are provided to separate the two species. All stages of An. lepidotus are easily separated from other currently known species in subgenus Kerteszia and a new key to the females of An. (Kerteszia) is given. Previously published distribution, bionomics, and medical significance data are corrected and enhanced. C1 [Ruiz-Lopez, Freddy; Pecor, James E.; Wilkerson, Richard C.] Museum Support Ctr, Walter Reed Biosystemat Unit, Smithsonian Inst, Suitland, MD 20746 USA. [Savage, Harry M.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO 80521 USA. [Pecor, James E.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. RP Wilkerson, RC (reprint author), Museum Support Ctr, Walter Reed Biosystemat Unit, Smithsonian Inst, 4210 Silver Hill Rd, Suitland, MD 20746 USA. EM skeeterdoc@gmail.com; ruizj@si.edu; calderon_entomol@hotmail.com; hms1@cdc.gov; pecorj@si.edu; wilkersonr@si.edu FU National Research Council, National Academy of Science, Washington, DC; BOSTID [MVR-PE-4-84-35]; Walter Reed Biosystematics Unit (WRBU); National Museum of Natural History; Smithsonian Institution, Washington, DC; National Institutes of Health [2R01AI054139] FX We gratefully acknowledge the National Research Council, National Academy of Science, Washington, DC, for support with BOSTID Grant No. MVR-PE-4-84-35, the Walter Reed Biosystematics Unit (WRBU), National Museum of Natural History, Smithsonian Institution, Washington, DC, National Institutes of Health grant 2R01AI054139 to Jan Conn, the Instituto Nacional de Salud, Ministerio de Salud, Lima, Peru, the Naval Medical Research Institute (NAMRID), Lima Detachment, Lima, Peru, and to Kelly Swing and the staff at the Tiputini Biodiversity Station, Universidad San Francisco de Quito, who made collections of crucial specimens for this study possible. We are very grateful to LCDR Chris H. Gardiner, for local assistance in Lima and in Junin Province. The hard field and laboratory work of Roberto Falcone and Victor Zambrano in Peru was of great value to the study. Special thanks are also due Taina Litwak for the beautiful illustrations, Judith Stoffer for the photomicrographs and their preparation for publication. We also appreciate the helpful and constructive edits and comments provided by Ralph Harbach, Anice Sallum, and Yvonne-Marie Linton. NR 59 TC 4 Z9 5 U1 0 U2 0 PU MAGNOLIA PRESS PI AUCKLAND PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND SN 1175-5326 EI 1175-5334 J9 ZOOTAXA JI Zootaxa PD MAR 1 PY 2012 IS 3218 BP 1 EP 17 PG 17 WC Zoology SC Zoology GA 903LH UT WOS:000301117500001 ER PT J AU Grieger, KD Linkov, I Hansen, SF Baun, A AF Grieger, Khara D. Linkov, Igor Hansen, Steffen Foss Baun, Anders TI Environmental risk analysis for nanomaterials: Review and evaluation of frameworks SO NANOTOXICOLOGY LA English DT Article DE Environmental risk assessment; nanomaterials; risk analysis ID MULTICRITERIA DECISION-ANALYSIS; RESEARCH PRIORITIES; LIFE-CYCLE; NANOTECHNOLOGY; MANAGEMENT; NANOPARTICLES; UNCERTAINTIES; TOXICITY; PRODUCTS; SYSTEM AB In response to the challenges of conducting traditional human health and ecological risk assessment for nanomaterials (NM), a number of alternative frameworks have been proposed for NM risk analysis. This paper evaluates various risk analysis frameworks proposed for NM based on a number of criteria. Among other results, most frameworks were found to be flexible for multiple NM, suitable for multiple decision contexts, included life cycle perspectives and precautionary aspects, transparent and able to include qualitative and quantitative data. Nevertheless, most frameworks were primarily applicable to occupational settings with minor environmental considerations, and most have not been thoroughly tested on a wide range of NM. Care should also be taken when selecting the most appropriate risk analysis strategy for a given risk context. Given this, we recommend a multi-faceted approach to assess the environmental risks of NM as well as increased applications and testing of the proposed frameworks for different NM. C1 [Grieger, Khara D.; Hansen, Steffen Foss; Baun, Anders] Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark. [Linkov, Igor] US Army Corps Engineers, US Army Engineer Res & Dev Ctr, Concord, MA USA. RP Grieger, KD (reprint author), Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark. EM kdg@env.dtu.dk RI Baun, Anders/A-1330-2010; Hansen, Steffen /D-1366-2014 OI Baun, Anders/0000-0003-1396-408X; Hansen, Steffen /0000-0003-4342-7779 FU US Army Engineer Research and Development Center Nanotechnology Focus Area FX We would like to sincerely thank the authors of the investigated frameworks for their communication and responses to our analysis. Many of them provided extremely valuable insight and further information on their strategies as well as critical information pertinent to this analysis. Specifically we would like to thank Mike Davis and Juergen Hock especially for their very elaborate explanations and responses, as well as Markus Widmer, Christine Hendren, Markus Widmer, Jo Anne Shakin, Christoph Studer, Hens-Henning Homann, and Ortwin Renn for their discussions, communications and responses. This study was funded in part by the US Army Engineer Research and Development Center Nanotechnology Focus Area. Permission was granted by the Chief of Engineers to publish this information. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army or other sponsor agencies. NR 79 TC 38 Z9 44 U1 2 U2 51 PU INFORMA HEALTHCARE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 1743-5390 J9 NANOTOXICOLOGY JI Nanotoxicology PD MAR PY 2012 VL 6 IS 2 BP 196 EP 212 DI 10.3109/17435390.2011.569095 PG 17 WC Nanoscience & Nanotechnology; Toxicology SC Science & Technology - Other Topics; Toxicology GA 885NB UT WOS:000299784600008 PM 21486187 ER PT J AU Dean, TR Hromadka, TV Kastner, T Phillips, M AF Dean, T. R. Hromadka, T. V., II Kastner, Thomas Phillips, Michael TI Modeling potential flow using Laurent series expansions and boundary elements SO NUMERICAL METHODS FOR PARTIAL DIFFERENTIAL EQUATIONS LA English DT Article DE complex variables; CVBEM; complex variable boundary elements; Laurent Series; potential flow AB The fundamental underpinnings of the well-known Bernoulli's Equation, as used to describe steady state two-dimensional flow of an ideal incompressible irrotational flow, are typically described in terms of partial differential equations. However, it has been shown that the Cauchy Integral Theorem of standard complex variables also explain the Bernoulli's Equation and, hence, can be directly used to model problems of ideal fluid flow (or other potential problems such as electrostatics among other topics) using approximation function techniques such as the complex variable boundary element method (CVBEM). In this article, the CVBEM is extended to include Laurent Series expansions about singular points located outside of the problem domain union boundary. It is shown that by including such negatively powered complex monomials in the CVBEM formulation, considerable power is introduced to model potential flow problems. (c) 2010 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 28: 573-586,2012 C1 [Hromadka, T. V., II; Kastner, Thomas; Phillips, Michael] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Dean, T. R.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM tedhromadka@yahoo.com NR 8 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0749-159X J9 NUMER METH PART D E JI Numer. Meth. Part Differ. Equ. PD MAR PY 2012 VL 28 IS 2 BP 573 EP 586 DI 10.1002/num.20636 PG 14 WC Mathematics, Applied SC Mathematics GA 882FH UT WOS:000299547400013 ER PT J AU Liu, MX Xu, ZG Su, FB Tao, R AF Liu, Mingxing Xu, Zhigang Su, Fubing Tao, Ran TI Rural tax reform and the extractive capacity of local state in China SO CHINA ECONOMIC REVIEW LA English DT Article DE Central-local relations; Local public finance; Farmers' burdens; Rural Tax reform; China ID FEDERALISM; TAXATION; STYLE AB China's fiscal arrangement in the 19805 has preserved local governments' incentive but the 1994 fiscal reform recentralized revenues. Since then, farmers' tax burdens have risen steeply and become a major challenge to the state legitimacy. How to account for the huge regional variation? Why were some localities able to tax more heavily than others? Based on a national survey of village governance in China, we examine farmers' burdens empirically and identify political and social factors that explain the local governments' ability to tax farmers. This paper suggests that developments since the 1990s have shown that it overstates local discretionary power and does not pay enough attention to societal forces in understanding local public finance. (C) 2011 Published by Elsevier Inc. C1 [Tao, Ran] Renmin Univ China, Sch Econ, China Ctr Publ Econ & Governance CCPEG, Beijing 100872, Peoples R China. [Liu, Mingxing] Peking Univ, China Inst Educ Finance Res, Beijing, Peoples R China. [Xu, Zhigang] Chinese Acad Sci, Ctr Chinese Agr Policy, Beijing 100864, Peoples R China. [Su, Fubing] USA, Dept Polit Sci, Vassar Coll, Washington, DC USA. RP Tao, R (reprint author), Renmin Univ China, Sch Econ, China Ctr Publ Econ & Governance CCPEG, Room 1038 Minde Zhulou 59,ZhongguanCun St, Beijing 100872, Peoples R China. EM rantao1972@ruc.edu.cn NR 53 TC 10 Z9 10 U1 2 U2 18 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1043-951X EI 1873-7781 J9 CHINA ECON REV JI China Econ. Rev. PD MAR PY 2012 VL 23 IS 1 BP 190 EP 203 DI 10.1016/j.chieco.2011.10.002 PG 14 WC Economics SC Business & Economics GA 878FO UT WOS:000299241100014 ER PT J AU Gomes, C Castell-Perez, ME Chimbombi, E Karagoz, I Hare, B Liang, YL Sue, HJ Sherman, P Dunne, P Wright, AO AF Gomes, Carmen Castell-Perez, M. Elena Chimbombi, Ezekiel Karagoz, Isin Hare, Brian Liang, Yi-Ling Sue, Hung-Jue Sherman, Peter Dunne, Patrick Wright, Alan O. TI Quality of olive oil reformulated MRE entree packaged in oxygen-absorbing film SO LWT-FOOD SCIENCE AND TECHNOLOGY LA English DT Article DE Oxygen absorber; Copolymer film; Active packaging; Shelf life; Meal ready-to-eat ID 2-THIOBARBITURIC ACID TEST; MALONALDEHYDE; FOODS; FISH AB An iron-based oxygen absorber (ABSO(2)RBq (R)) activated by moisture was incorporated into a retort laminate and used to package chicken pesto with noodles. The effect of packaging material (regular MRE and oxygen-absorbing pouches) and reformulation with olive oil on the quality and shelf life of the entre were investigated. Physical properties (color, texture, moisture, water activity), chemical properties (pH, TBARS), and microbiological quality (Total aerobic, coliforms, Escherichia coli, yeast and Molds, Anaerobic plate counts) were measured in triplicates in an accelerated shelf-life study for 6 months at 37.8 degrees C. Samples stored at 26.7 degrees C for 12 months served as calibrated controls. Consumer and trained panel tests were carried out using a 9-point hedonic scale. The ABSO(2)RB (R) pouches performed well in terms of seal integrity and strength and limited the formation of rancid fatty acids in olive oil throughout the shelf-life study. Soybean formulations in ABSO(2)RB (R) pouches had the lowest (p < 0.05) Thiobarbituric Acid Reactive Substances (TBARS) value. Consumer and trained panelists accepted the olive oil formulations, in both packages. Results from this study will help MRE developers to expand the number of items using healthier oils. If future considerations to replace MRE packaging are needed, the ABSO(2)RB (R) film will be a suitable alternative. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Gomes, Carmen; Castell-Perez, M. Elena; Karagoz, Isin] Texas A&M Univ, Dept Biol & Agr Engn, College Stn, TX 77843 USA. [Hare, Brian; Liang, Yi-Ling; Sue, Hung-Jue] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Sherman, Peter; Dunne, Patrick; Wright, Alan O.] USA, Res Dev & Engn Command, Natick, MA 01760 USA. RP Castell-Perez, ME (reprint author), Texas A&M Univ, Dept Biol & Agr Engn, 303G Scoates Hall, College Stn, TX 77843 USA. EM ecastell@tamu.edu RI Sue, HJ/A-4051-2008; Gomes, Carmen/J-5091-2015 OI Sue, HJ/0000-0002-3898-4469; Gomes, Carmen/0000-0003-0095-6478 FU CORANET II (Combat Ration Network for Technology Implementation) [STP 2021] FX The authors want to thank Drs. Osborn, S. Smith, S. Nowak, and R. Miller, Department of Animal Science, Texas A&M University, for allowing us to use their lab facilities and equipment to conduct TBARs, FAME, and sensory analysis, respectively. We thank Dr. Colin Mayer, Cadillac Products Packaging Company, for supplying the film and providing technical support. We also want to thank the students, staff, and faculty of Texas A&M University campus for their willingness to participate in sensory testing. This research was funded by CORANET II (Combat Ration Network for Technology Implementation) as Short term Project STP 2021. NR 27 TC 2 Z9 2 U1 1 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0023-6438 EI 1096-1127 J9 LWT-FOOD SCI TECHNOL JI LWT-Food Sci. Technol. PD MAR PY 2012 VL 45 IS 2 BP 191 EP 197 DI 10.1016/j.lwt.2011.09.005 PG 7 WC Food Science & Technology SC Food Science & Technology GA 847WI UT WOS:000297002800010 ER PT J AU Yao, B Simkin, B Majumdar, B Smith, C van den Bergh, M Cho, K Sohn, YH AF Yao, B. Simkin, B. Majumdar, B. Smith, C. van den Bergh, M. Cho, K. Sohn, Y. H. TI Strain-induced grain growth of cryomilled nanocrystalline Al in trimodal composites during forging SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Strain-induced grain growth; Nanocrystalline; Al; Trimodal composites ID TENSILE PLASTIC-DEFORMATION; BOUNDARY MOTION; NANOSTRUCTURED MATERIALS; THERMAL-STABILITY; ALUMINUM; ALLOY; MECHANISMS; STRENGTH; SIZE; MIGRATION AB Grain growth of nanocrystalline aluminum (Al-nc) in trimodal Al metal-matrix-composites (MMCs) during hot forging was investigated. The Al-nc phase formed through cryomilling of inert gas-atomized powders in liquid nitrogen has an average grain size down to 21 nm, exhibits excellent thermal stability. However, substantial grain growth of Al-nc up to 63 nm was observed when the Al MMCs were thermo-mechanically processed even at relatively low temperatures. Grain growth of the cryomilled Al-nc phase in trimodal Al MMCs after hot forging was documented with respect to temperature ranging from 175 degrees C to 287 degrees C, true strain ranging from 0.4 to 135 and strain rate ranging from 0.1 to 0.55 s(-1). Hollow cone dark field imaging technique was employed to provide statistically confident measurements of Al-nc grain size that ranged from 21 to 63 nm. An increase in forging temperature and an increase in true strain were correlated with an increase in grain size of Al-nc. Results were correlated to devise a phenomenological grain growth model for forging that takes strain, strain rate and temperature into consideration. Activation energy for the grain growth during thermo-mechanical hot-forging was determined to be 35 kJ/mol, approximately a quarter of activation energy for bulk diffusion of Al and a half of activation energy for static recrystallization. (C) 2011 Elsevier B.V. All rights reserved. C1 [Yao, B.; Sohn, Y. H.] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Yao, B.; Sohn, Y. H.] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Orlando, FL 32816 USA. [Simkin, B.; Majumdar, B.] New Mexico Inst Min & Technol, Dept Mat & Met Engn, Socorro, NM 87801 USA. [Smith, C.; van den Bergh, M.] DWA Aluminum Composites, Chatsworth, CA 91311 USA. [Cho, K.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, YH (reprint author), Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. EM Yongho.Sohn@ucf.edu RI Sohn, Yongho/A-8517-2010 OI Sohn, Yongho/0000-0003-3723-4743 FU U.S. Army Research Laboratory; Cooperative Agreement [W911NF-08-2-0026] FX Research was sponsored by U.S. Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-08-2-0026. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of U.S. Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 44 TC 7 Z9 7 U1 0 U2 17 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD FEB 28 PY 2012 VL 536 BP 103 EP 109 DI 10.1016/j.msea.2011.12.079 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 906BG UT WOS:000301319300015 ER PT J AU Lapchak, PH Ioannou, A Kannan, L Rani, P Lucca, JJD Tsokos, GC AF Lapchak, Peter H. Ioannou, Antonis Kannan, Lakshmi Rani, Poonam Lucca, Jurandir J. Dalle Tsokos, George C. TI Platelet-Associated CD40/CD154 Mediates Remote Tissue Damage after Mesenteric Ischemia/Reperfusion Injury SO PLOS ONE LA English DT Article ID INFLAMMATORY-BOWEL-DISEASE; ANTIGEN-INDUCED ARTHRITIS; ISCHEMIC-STROKE; P-SELECTIN; REPERFUSION INJURY; ENDOTHELIAL-CELLS; COMPLEMENT; LINK; ACTIVATION; MICE AB Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors in the process of tissue damage after ischemia reperfusion (I/R) injury. It is currently unknown whether platelets participate through the immunologically important molecules including, CD40 and when activated, CD154 (CD40L), in the pathogenesis of I/R injury. We hypothesized that constitutive expression of CD40 and activation-induced expression of CD154 on platelets mediate local mesenteric and remote lung tissue damage after I/R injury. Wild type (WT; C57BL/6J), CD40 and CD154 deficient mice underwent mesenteric ischemia for 30 minutes followed by reperfusion for 3 hours. WT mice subjected to mesenteric I/R injury displayed both local intestinal and remote lung damage. In contrast, there was significantly less intestinal damage and no remote lung injury in CD40 and CD154 deficient mice when compared to WT mice. Platelet-depleted WT mice transfused with platelets from CD40 or CD154 deficient mice failed to reconstitute remote lung damage. In contrast, when CD40 or CD154 deficient mice were transfused with WT platelets lung tissue damage was re-established. Together, these findings suggest that multiple mechanisms are involved in local and remote tissue injury and also identify platelet-expressed CD40 and/or CD154 as mediators of remote tissue damage. C1 [Lapchak, Peter H.; Ioannou, Antonis; Kannan, Lakshmi; Rani, Poonam; Tsokos, George C.] Beth Israel Deaconess Med Ctr, Dept Med, Div Rheumatol, Boston, MA 02215 USA. [Lapchak, Peter H.; Ioannou, Antonis; Kannan, Lakshmi; Rani, Poonam; Tsokos, George C.] Harvard Univ, Sch Med, Boston, MA USA. [Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA. RP Lapchak, PH (reprint author), Beth Israel Deaconess Med Ctr, Dept Med, Div Rheumatol, Boston, MA 02215 USA. EM aioannou@bicmc.harvard.edu; gtsokos@bidmc.harvard.edu OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530, W81XWH-09-1-0536] FX The research presented herein was supported by grant numbers W81XWH-09-1-0530 and W81XWH-09-1-0536 from Medical Research and Material Command of the Department of the Army. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 46 TC 11 Z9 11 U1 0 U2 4 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 27 PY 2012 VL 7 IS 2 AR e32260 DI 10.1371/journal.pone.0032260 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 927OV UT WOS:000302918500069 PM 22384195 ER PT J AU Tachibana, M Sato, C Otsuki, H Sattabongkot, J Kaneko, O Torii, M Tsuboi, T AF Tachibana, Mayumi Sato, Chiho Otsuki, Hitoshi Sattabongkot, Jetsumon Kaneko, Osamu Torii, Motomi Tsuboi, Takafumi TI Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate SO VACCINE LA English DT Article DE DNA vaccine; Gametocyte; Malaria; Plasmodium vivax; Pvs230; Transmission-blocking vaccine ID HUMAN MALARIA; SEXUAL-STAGE; PFS230; FALCIPARUM; DNA; ANTIGEN; IMMUNOGENICITY; ANTIBODIES; VAXFECTIN; TRIAL AB The malaria transmission-blocking vaccine (TBV) aims to interfere the development of malaria parasite in the mosquito and prevent further transmission in the community. So far only two TBV candidates have been identified in Plasmodium vivax; ookinete surface proteins Pvs25 and Pvs28. The pvs230 (PVX_003905) is reported as an ortholog of Pfs230, a gametocyte/gamete stage TBV candidate in Plasmodium falciparum, however its candidacy for TBV has never been tested. Therefore here, we have investigated whether Pvs230 can be a TBV candidate using P. vivax samples obtained from Thailand. The mouse antiserum raised against the plasmid expressing CRDs I-IV of Pvs230 detected Pvs230 protein in the lysate of P. vivax gametocyte in western blot analysis under non-reducing condition. From the localization of Pvs230 on the outer most regions of gametocyte in the immunofluorescence assay, it appears that Pvs230 is localized on the surface of gametes. Importantly, the anti-Pvs230 mouse serum significantly reduced the number of P. vivax oocysts developed in the mosquito midgut. Moreover, the polymorphism in Pvs230 CRDs I-IV is limited suggesting that it may not be an impediment for the utilization of Pvs230 as an effective TBV candidate. In conclusion, our results show that Pvs230 is a transmission-blocking vaccine candidate of P. vivax. (C) 2012 Elsevier Ltd. All rights reserved. C1 [Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. [Torii, Motomi; Tsuboi, Takafumi] Ehime Univ, Ehime Proteomed Res Ctr, Toon, Ehime 7910295, Japan. [Kaneko, Osamu] Nagasaki Univ, Inst Trop Med NEKKEN, Dept Protozool, Nagasaki 8528523, Japan. [Kaneko, Osamu] Nagasaki Univ, Global Ctr Excellence Program, Nagasaki 8528523, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Otsuki, Hitoshi] Tottori Univ, Fac Med, Div Med Zool, Yonago, Tottori 6838503, Japan. [Tachibana, Mayumi; Sato, Chiho; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Toon, Ehime 7910295, Japan. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. EM torii@m.ehime-u.ac.jp; tsuboi@ccr.ehime-u.ac.jp FU Ministry of Education, Culture, Sports, Science and Technology [21022034, 21249028, 21406010, 23406007]; Ministry of Health, Labour, and Welfare, Japan [H21-Chikyukibo-ippan-005] FX We thank the staff of the Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, for their technical assistance, and Thangavelu U. Arumugam for the critical reading of the manuscript. We also thank Vical Inc. for providing the VR1020 DNA vaccine plasmid and Vaxfectin (R) adjuvant. This research was supported in part by the Ministry of Education, Culture, Sports, Science and Technology (21022034, 21249028, 21406010, 23406007), and by the Ministry of Health, Labour, and Welfare, Japan (H21-Chikyukibo-ippan-005). NR 25 TC 15 Z9 18 U1 0 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD FEB 27 PY 2012 VL 30 IS 10 BP 1807 EP 1812 DI 10.1016/j.vaccine.2012.01.003 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 911BX UT WOS:000301693400008 PM 22245309 ER PT J AU Pan, YL Hill, SC Coleman, M AF Pan, Yong-Le Hill, Steven C. Coleman, Mark TI Photophoretic trapping of absorbing particles in air and measurement of their single-particle Raman spectra SO OPTICS EXPRESS LA English DT Article ID AEROSOL DROPLETS; BOTTLE BEAM; SPECTROSCOPY; MANIPULATION; TWEEZERS; GERMINATION; CELLS AB A new method is demonstrated for optically trapping micron-sized absorbing particles in air and obtaining their single-particle Raman spectra. A 488-nm Gaussian beam from an Argon ion laser is transformed by conical lenses (axicons) and other optics into two counter-propagating hollow beams, which are then focused tightly to form hollow conical beams near the trapping region. The combination of the two coaxial conical beams, with focal points shifted relative to each other along the axis of the beams, generates a low-light-intensity biconical region totally enclosed by the high-intensity light at the surface of the bicone, which is a type of bottle beam. Particles within this region are trapped by the photophoretic forces that push particles toward the low-intensity center of this region. Raman spectra from individual trapped particles made from carbon nanotubes are measured. This trapping technique could lead to the development of an on-line real-time single-particle Raman spectrometer for characterization of absorbing aerosol particles. (C) 2012 Optical Society of America C1 [Pan, Yong-Le; Hill, Steven C.; Coleman, Mark] USA, Res Lab, Adelphi, MD 20783 USA. RP Pan, YL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM yongle.pan.civ@mail.mil FU U.S. Army Research Laboratory (ARL) Director's Research Initiative (DRI) [FY10 CIS-05] FX This research was supported by the U.S. Army Research Laboratory (ARL) Director's Research Initiative (DRI) project (FY10 CIS-05). NR 26 TC 19 Z9 22 U1 2 U2 25 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 27 PY 2012 VL 20 IS 5 BP 5325 EP 5334 DI 10.1364/OE.20.005325 PG 10 WC Optics SC Optics GA 902QL UT WOS:000301053200053 PM 22418339 ER PT J AU Serak, SV Hakobyan, RS Nersisyan, SR Tabiryan, NV White, TJ Bunning, TJ Steeves, DM Kimball, BR AF Serak, Svetlana V. Hakobyan, Rafael S. Nersisyan, Sarik R. Tabiryan, Nelson V. White, Timothy J. Bunning, Timothy J. Steeves, Diane M. Kimball, Brian R. TI All-optical diffractive/transmissive switch based on coupled cycloidal diffractive waveplates SO OPTICS EXPRESS LA English DT Article ID NEMATIC LIQUID-CRYSTALS; GRATINGS; POLARIZATION; REFLECTORS; MICROSCOPY; PHASE; FILMS AB Pairs of cycloidal diffractive waveplates can be used to doubly diffract or collinearly propagate laser radiation of the appropriate wavelength. The use of a dynamic phase retarder placed in between the pair can be utilized to switch between the two optical states. We present results from the implementation of an azo-based retarder whose optical properties can be modulated using light itself. We show fast and efficient switching between the two states for both CW and single nanosecond laser pulses of green radiation. Contrasts greater than 100: 1 were achieved. The temporal response as a function of light intensity is presented and the optical switching is shown to be polarization independent. (C) 2012 Optical Society of America C1 [Serak, Svetlana V.; Hakobyan, Rafael S.; Nersisyan, Sarik R.; Tabiryan, Nelson V.] Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. [White, Timothy J.; Bunning, Timothy J.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Steeves, Diane M.; Kimball, Brian R.] USA, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Serak, SV (reprint author), Beam Engn Adv Measurements Co, Winter Pk, FL 32789 USA. EM Timothy.Bunning@wpafb.af.mil RI White, Timothy/D-4392-2012 NR 40 TC 7 Z9 7 U1 1 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD FEB 27 PY 2012 VL 20 IS 5 BP 5460 EP 5469 DI 10.1364/OE.20.005460 PG 10 WC Optics SC Optics GA 902QL UT WOS:000301053200066 PM 22418352 ER PT J AU Adler, M AF Adler, Michael TI How a Neurotoxin Survives SO SCIENCE LA English DT Editorial Material ID BOTULINUM NEUROTOXIN C1 USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Adler, M (reprint author), USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Analyt Toxicol Div, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM michael.adler2@us.army.mil FU NIAID NIH HHS [R01 AI091823] NR 8 TC 3 Z9 3 U1 0 U2 0 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD FEB 24 PY 2012 VL 335 IS 6071 BP 928 EP 929 DI 10.1126/science.1219602 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 900ZQ UT WOS:000300931800033 PM 22362997 ER PT J AU Pasiakos, SM Karl, JP Lutz, LJ Murphy, NE Margolis, LM Rood, JC Cable, SJ Williams, KW Young, AJ McClung, JP AF Pasiakos, Stefan M. Karl, J. Philip Lutz, Laura J. Murphy, Nancy E. Margolis, Lee M. Rood, Jennifer C. Cable, Sonya J. Williams, Kelly W. Young, Andrew J. McClung, James P. TI Cardiometabolic Risk in US Army Recruits and the Effects of Basic Combat Training SO PLOS ONE LA English DT Article ID CORONARY-HEART-DISEASE; PLACEBO-CONTROLLED TRIAL; PREDICTING BODY DENSITY; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR RISK; UNITED-STATES; PHYSICAL-ACTIVITY; NATIONAL-HEALTH; YOUNG-ADULTS; BLOOD-LIPIDS AB Background: Cardiometabolic disease risk in US military recruits and the effects of military training have not been determined. This study examined lifestyle factors and biomarkers associated with cardiometabolic risk in US Army recruits (209; 118 male, 91 female, 23 +/- 5 yr) before, during, and after basic combat training (BCT). Methodology/Principal Findings: Anthropometrics; fasting total (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol; triglycerides (TG); glucose; and insulin were measured at baseline and every 3 wks during the 10 wk BCT course. At baseline, 14% of recruits were obese (BMI>30 kg/m(2)), 27% were cigarette smokers, 37% were sedentary, and 34% reported a family history of cardiometabolic disease. TC was above recommended levels in 8%, LDL in 39%, TG in 5%, and glucose in 8% of recruits, and HDL was below recommended levels in 33% of recruits at baseline. By week 9, TC decreased 8%, LDL 10%, TG 13%, glucose 6% and homeostasis model assessment of insulin resistance (HOMA-IR) 40% in men (P<0.05). In women, TC, LDL, glucose and HOMA-IR were decreased from baseline at weeks 3 and 6 (P<0.05), but were not different from baseline levels at week 9. During BCT, body weight declined in men but not women, while body fat percentage declined in both men and women (P<0.05). Conclusions/Significance: At the start of military service, the prevalence of cardiometabolic risk in US military recruits is comparable to that reported in similar, college-aged populations. Military training appears to be an effective strategy that may mitigate risk in young people through improvements in lipid profiles and glycemic control. C1 [Pasiakos, Stefan M.; Karl, J. Philip; Lutz, Laura J.; Murphy, Nancy E.; Margolis, Lee M.; Young, Andrew J.; McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Rood, Jennifer C.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA. [Cable, Sonya J.; Williams, Kelly W.] Directorate Basic Combat Training, Ft Jackson, SC USA. RP Pasiakos, SM (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM james.mcclung@amedd.army.mil RI McClung, James/A-1989-2009; Pasiakos, Stefan/E-6295-2014; OI Pasiakos, Stefan/0000-0002-5378-5820; Karl, J. Philip/0000-0002-5871-2241; , Lee/0000-0002-0652-1304 FU United States Army Medical Research and Materiel Command FX This work was funded by the United States Army Medical Research and Materiel Command. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 52 TC 9 Z9 9 U1 0 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 23 PY 2012 VL 7 IS 2 AR e31222 DI 10.1371/journal.pone.0031222 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 927NZ UT WOS:000302916100016 PM 22384004 ER PT J AU Mukhopadhyay, S Pandey, R Karna, SP AF Mukhopadhyay, Saikat Pandey, Ravindra Karna, Shashi P. TI Controlling the Performance of a Three-Terminal Molecular Transistor: Conformational versus Conventional Gating SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID PHOTOSYNTHETIC REACTION CENTERS; ELECTRON-TRANSFER REACTION; SINGLE-MOLECULE; RHODOBACTER-SPHAEROIDES; CONDUCTANCE; GATE; DYNAMICS; JUNCTION; DEPENDENCE; MECHANISM AB The effect of conformational changes in the gate arm of a three-terminal device is investigated. In the ground state, the gate (triphenyl) arm is nonplanar, where the middle phenyl ring is approximately 30 degrees out-of-plane relative to other two rings. At this geometry, the calculated tunnel current (I-d) as a function of external bias (V-ds) across the two D-A substituted arms exhibits a typical insulator-semiconductor behavior. Similar I-d-V-ds characteristics is calculated when planarity of the triphenyl arm behavior. Similar I-d-V-ds characteristics is calculated when planarity of the triphenyl arm is restored. However, a significant increase, by more than an order of magnitude, and a distinct variation in the current are predicted in its operational mode (V-ds > 1.5 V) when additional nonplanarity is induced in the triphenyl chain. Analysis of the results suggest that, unlike in "voltage" gating, neither the HOMO-LUMO gap nor the dipole moment of the system undergo significant changes due to pure conformational gating, as observed in this study. Instead, the observed conformational gating affects the current via localization/delocalization of the electronic wave function in the conduction channel. Furthermore, the tunneling current corresponding to conformational gating in two different directions appears to exhibit oscillatory nature with a phase factor of pi/2 in the presence of the gate field. The current modulation is found to reach its maximum only under exclusive effect of voltage or conformational gating and diminishes when both of them are present. C1 [Mukhopadhyay, Saikat; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN,RDRL WM, Aberdeen Proving Ground, MD USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; Shashi.p.karna.civ@mail.mil RI Mukhopadhyay, Saikat/B-4402-2011 FU Army Research Office [W911NF-09-1-0221] FX The helpful discussions with Haiying He, Ranjit Pati, and Wil Slough are acknowledged. The work at Michigan Technological University was performed under support by Army Research Office through contract number W911NF-09-1-0221. NR 56 TC 8 Z9 8 U1 0 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD FEB 23 PY 2012 VL 116 IS 7 BP 4840 EP 4847 DI 10.1021/jp208983d PG 8 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 903XQ UT WOS:000301156500061 ER PT J AU Uchimiya, M Bannon, DI Wartelle, LH AF Uchimiya, Minori Bannon, Desmond I. Wartelle, Lynda H. TI Retention of Heavy Metals by Carboxyl Functional Groups of Biochars in Small Arms Range Soil SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article DE biochar; surface functional group; oxidation; heavy metal; soil ID CHARRED PLANT FRAGMENTS; VOLCANIC ASH SOILS; BLACK CARBON; ACTIVATED CARBONS; ORGANIC-MATTER; PARTICLE-SIZE; SANDY SOILS; NITRIC-ACID; SORPTION; OXIDATION AB Long-term effectiveness of biochar for heavy metal stabilization depends upon biochar's sorptive property and recalcitrance in soil. To understand the role of carboxyl functional groups on heavy metal stabilization, cottonseed hull biochar and flax shive steam-activated biochar having a low O/C ratio (0.04-0.06) and high fixed carbon content (similar to 80% dry weight basis) were oxidized using concentrated H2SO4/HNO3 and 30% HNO3. Oxidized and unoxidized biochars were characterized for O/C ratio, total acidity, pH, moisture, ash, volatile matter, and fixed carbon contents, Brunauer-Emmett-Teller surface area, and attenuated total reflectance Fourier transform infrared spectral features. Characterized biochars were amended (2%, 5%, 10%, and 20% in grams of biochar per gram of soil) on a sandy, slightly acidic (pH 6.27) heavy metal contaminated small arms range soil fraction (<250 mu m) having low total organic carbon (0.518%) and low cation exchange capacity (0.95 cmol(c) kg(-1)). Oxidized biochars rich in carboxyl functional groups exhibited significantly greater Pb, Cu, and Zn stabilization ability compared to unoxidized biochars, especially in pH 4.9 acetate buffer (standard solution for the toxicity characteristic leaching procedure). Oppositely, only oxidized biochars caused desorption of Sb, indicating a counteracting impact of carboxyl functional groups on the solubility of anions and cations. The results suggested that appropriate selection of biochar oxidant will produce recalcitrant biochars rich in carboxyl functional groups for a long-term heavy metal stabilization strategy in contaminated soils. C1 [Uchimiya, Minori; Wartelle, Lynda H.] ARS, USDA, So Reg Res Ctr, New Orleans, LA 70124 USA. [Bannon, Desmond I.] USA, Toxicol Portfolio, Army Inst Publ Hlth, Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. RP Uchimiya, M (reprint author), ARS, USDA, So Reg Res Ctr, 1100 Robert E Lee Blvd, New Orleans, LA 70124 USA. EM sophie.uchimiya@ars.usda.gov NR 54 TC 58 Z9 67 U1 11 U2 132 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD FEB 22 PY 2012 VL 60 IS 7 BP 1798 EP 1809 DI 10.1021/jf2047898 PG 12 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA 897IT UT WOS:000300644100026 PM 22280497 ER PT J AU Ruiz-Lopez, F Wilkerson, RC Conn, JE McKeon, SN Levin, DM Quinones, ML Povoa, MM Linton, YM AF Ruiz-Lopez, Freddy Wilkerson, Richard C. Conn, Jan E. McKeon, Sascha N. Levin, David M. Quinones, Martha L. Povoa, Marinete M. Linton, Yvonne-Marie TI DNA barcoding reveals both known and novel taxa in the Albitarsis Group (Anopheles: Nyssorhynchus) of Neotropical malaria vectors SO PARASITES & VECTORS LA English DT Article DE Albitarsis Group; barcoding; COI; new species; An. albitarsis G; An. albitarsis H; An. albitarsis I ID POLYMERASE-CHAIN-REACTION; MARAJOARA DIPTERA-CULICIDAE; MITOCHONDRIAL-DNA; COMPLEX DIPTERA; COMPARATIVE SUSCEPTIBILITY; GENE-SEQUENCES; BRAZIL; COLOMBIA; IDENTIFICATION; MOSQUITOS AB Background: Mosquitoes belonging to the Albitarsis Group (Anopheles: Nyssorhynchus) are of importance as malaria vectors across the Neotropics. The Group currently comprises six known species, and recent studies have indicated further hidden biodiversity within the Group. DNA barcoding has been proposed as a highly useful tool for species recognition, although its discriminatory utility has not been verified in closely related taxa across a wide geographic distribution. Methods: DNA barcodes (658 bp of the mtDNA Cytochrome c Oxidase - COI) were generated for 565 An. albitarsis s.l. collected in Argentina, Brazil, Colombia, Paraguay, Trinidad and Venezuela over the past twenty years, including specimens from type series and type localities. Here we test the utility of currently advocated barcoding methodologies, including the Kimura-two-parameter distance model (K2P) and Neighbor-joining analysis (NJ), for determining species delineation within mosquitoes of the Neotropical Albitarsis Group of malaria vectors (Anopheles: Nyssorhynchus), and compare results with Bayesian analysis. Results: Species delineation through barcoding analysis and Bayesian phylogenetic analysis, fully concur. Analysis of 565 sequences (302 unique haplotypes) resolved nine NJ tree clusters, with less than 2% intra-node variation. Mean intra-specific variation (K2P) was 0.009 (range 0.002 - 0.014), whereas mean inter-specific divergence were several-fold higher at 0.041 (0.020 - 0.056), supporting the reported "barcoding gap". These results show full support for separate species status of the six known species in the Albitarsis Group (An. albitarsis s.s., An. albitarsis F, An. deaneorum, An. janconnae, An. marajoara and An. oryzalimnetes), and also support species level status for two previously detected lineages - An. albitarsis G &An. albitarsis I (designated herein). In addition, we highlight the presence of a unique mitochondrial lineage close to An. deaneorum and An. marajoara (An. albitarsis H) from Rondonia and Mato Grosso in southwestern Brazil. Further integrated studies are required to confirm the status of this lineage. Conclusions: DNA barcoding provides a reliable means of identifying both known and undiscovered biodiversity within the closely related taxa of the Albitarsis Group. We advocate its usage in future studies to elucidate the vector competence and respective distributions of all eight species in the Albitarsis Group and the novel mitochondrial lineage (An. albitarsis H) recovered in this study. C1 [Ruiz-Lopez, Freddy; Wilkerson, Richard C.; Levin, David M.; Linton, Yvonne-Marie] Walter Reed Army Inst Res, Entomol Branch, Silver Spring, MD 20910 USA. [Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Griffin Lab, Albany, NY USA. [Conn, Jan E.; McKeon, Sascha N.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY USA. [Quinones, Martha L.] Univ Nacl Colombia, Fac Med, Bogota, DC, Colombia. [Povoa, Marinete M.] Inst Evandro Chagas, Ananindeua, Para, Brazil. [Linton, Yvonne-Marie] Nat Hist Museum, Dept Entomol, London SW7 5BD, England. RP Ruiz-Lopez, F (reprint author), Walter Reed Army Inst Res, Entomol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ruizj@si.edu OI Conn, Jan/0000-0002-5301-7020 FU Natural History Museum, London; UNICEF/UNDP/World Bank/WHO [A50252]; Consortium for the Barcode of Life (CBOL); Sloane Foundation; National Institute of Health (NIH), USA [2R01AI054139]; COLCIENCIAS [110134319196] FX This study forms part of the larger objectives of the Mosquito Barcoding Initiative (MBI), led by the senior authors YML & RCW. This investigation received financial support from: supporters of the Natural History Museum, London to further the activities of the Mosquito Barcoding Initiative (to YML); the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR) (grant A50252 to YML), Consortium for the Barcode of Life (CBOL) (to YML & RCW) and The Sloane Foundation (to YML & RCW); from the National Institute of Health (NIH), USA, (grant 2R01AI054139 to JEC) and COLCIENCIAS (grant 110134319196 to MLQ). We gratefully acknowledge Dr. Marta Moreno (Griffin Laboratory, Wadsworth Center, New York State Department of Health, Albany, NY, USA), Izis M. Carvalho and Galiza Primo (Instituto Evandro Chagas, Ananindeua, PA, Brazil) for their invaluable field assistance; Andrea Ormos for molecular laboratory support (Laboratories of Analytical Biology, Smithsonian Institution, Washington DC, USA), Dr. Desmond Foley (WRBU, Smithsonian Institution, Washington DC, USA) for elaboration of the map; Dr. Shazia Mahamdallie for helpful suggestions and discussions and Dr. Helena Brochero (Universidad Nacional de Colombia, Bogota D.C., Colombia) for donation of An. albitarsis F samples. NR 48 TC 45 Z9 45 U1 3 U2 24 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1756-3305 J9 PARASITE VECTOR JI Parasites Vectors PD FEB 21 PY 2012 VL 5 AR 44 DI 10.1186/1756-3305-5-44 PG 12 WC Parasitology SC Parasitology GA 942OD UT WOS:000304053600001 PM 22353437 ER PT J AU Greenman, JV Pasour, VB AF Greenman, J. V. Pasour, V. B. TI Threshold dynamics for periodically forced ecological systems: The control of population invasion and exclusion SO JOURNAL OF THEORETICAL BIOLOGY LA English DT Article DE Eco-epidemiological models; Phase control; Vaccination; Resonance; Apparent competition ID COMPARTMENTAL EPIDEMIC MODELS; BASIC REPRODUCTION NUMBER; VECTOR-BORNE DISEASES; INFECTIOUS-DISEASES; PULSE VACCINATION; PREY COMMUNITIES; RESONANCE; SEASONALITY; ENVIRONMENT; PREDATION AB Ecosystems are under increasing threat as a result of anthropogenic activity, through pollution, unregulated harvesting, habitat destruction and the inadvertent spread of pathogens and vertebrate and non-vertebrate species through global transportation links. Many of the necessary interventions to restore or restructure natural ecosystems require the exclusion of a population from the ecosystem or the inclusion of a population if robust biodiversity is the objective. The problem of how best to bring this about is not easy to solve in highly nonlinear systems, especially if the system is exposed to significant time varying external forces. We wish here to build on the understanding gained from previous work by developing an algebraic methodology that yields explicit formulae to analyse the effect of moderate multi-component forcing on the invasion/exclusion process. This can be of assistance to management in designing suitable intervention strategies if one or more of the forcing components is under management control. We apply this methodology to look at three important issues, involving the relationships between resonance and control, between vaccination policy and the stage structure of a disease and between apparent competition and coexistence. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Greenman, J. V.] Univ Stirling, Stirling FK9 4LA, Scotland. [Pasour, V. B.] USA, Res Off, Div Math Sci, Durham, NC USA. RP Greenman, JV (reprint author), Univ Stirling, Stirling FK9 4LA, Scotland. EM j.v.greenman@stir.ac.uk; virginia.pasour@us.army.mil FU University of Stirling, through the good offices of Leslie Smith FX We wish to thank Ben Adams and Miguel Sanjuan for helpful comments on aspects of the research presented in this paper. We would also like to thank the University of Stirling, through the good offices of Leslie Smith, for the funding, direct and indirect, that made this research possible. The algebraic and numerical calculations were carried out with Mathematica on a Macintosh computer. NR 42 TC 2 Z9 2 U1 3 U2 22 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0022-5193 J9 J THEOR BIOL JI J. Theor. Biol. PD FEB 21 PY 2012 VL 295 BP 154 EP 167 DI 10.1016/j.jtbi.2011.11.015 PG 14 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 880LL UT WOS:000299408500015 PM 22146345 ER PT J AU Higa, MM Petersen, J Hooper, J Doms, RW AF Higa, Meda M. Petersen, Josiah Hooper, Jay Doms, Robert W. TI Efficient production of Hantaan and Puumala pseudovirions for viral tropism and neutralization studies SO VIROLOGY LA English DT Article DE Virus entry; Hantavirus; Bunyaviridae; Glycoprotein; Puumala; Hantaan; Pseudovirions ID VESICULAR STOMATITIS-VIRUS; HANTAVIRUS PULMONARY SYNDROME; MEMBRANE-FUSION PROTEINS; HEMORRHAGIC-FEVER; RENAL SYNDROME; ANDES VIRUS; DNA VACCINATION; CELLULAR ENTRY; NIPAH-VIRUS; LOW PH AB Puumala (PUUV) and Hantaan (HTNV) viruses are hantaviruses within the family Bunyaviridae and associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in humans. Little is known about how these viruses interact with host cells, though pathogenic hantaviruses interact with alpha(v)beta(3) integrin. To study host cell interactions and rapidly test the ability of antibodies to prevent infection, we produced HTNV and PUUV pseudovirions on a vesicular stomatitis virus (VSV) core. Similar to replication-competent hantaviruses, infection was low-pH-dependent. Despite broad cell tropism, several human T cell lines were poorly permissive to hantavirus pseudovirions, compared to VSV, indicating a relative block to infection at the level of entry. Stable expression of alpha(v)beta(3) integrin in SupT1 cells did not restore infectivity. Finally, the pseudovirion system provided a rapid, quantitative, and specific method to screen for neutralizing antibodies in immune sera. (C) 2011 Published by Elsevier Inc. C1 [Higa, Meda M.; Petersen, Josiah; Doms, Robert W.] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. [Hooper, Jay] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. RP Doms, RW (reprint author), Univ Penn, Dept Microbiol, 3610 Hamilton Walk,225A Johnson Pavil, Philadelphia, PA 19104 USA. EM doms@mail.med.upenn.edu OI Hooper, Jay/0000-0002-4475-0415 FU U.S. Army Medical Research [T0038_08_RD]; NIH [U54 AI 057168, K12-GM081259]; [T32 AI055400] FX The authors wish to thank Elizabeth Henning for technical assistance with this project. Dr. Doug Lyles (Wake Forest University) kindly provided antibodies to VSV G (I14) and VSV M (23H12). Cell lines were generously provided by Paul Bates (IGH2, CF2TH), Mitch Weiss (K562), Wei Tong (HEL), and Jim Hoxie (MOLT, CEMx174). Portions of the research described herein were sponsored by the Military Infectious Disease Research Program, U.S. Army Medical Research and Material Command, Project no. T0038_08_RD. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense.; This work was supported in part by the NIH grant U54 AI 057168 to RW. MH was supported by the NIH grant K12-GM081259. JP was supported by T32 AI055400. NR 54 TC 9 Z9 10 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD FEB 20 PY 2012 VL 423 IS 2 BP 134 EP 142 DI 10.1016/j.virol.2011.08.012 PG 9 WC Virology SC Virology GA 885TI UT WOS:000299803300004 PM 22209230 ER PT J AU Lent, EM Crouse, LCB Quinn, MJ Wallace, SM AF Lent, Emily May Crouse, Lee C. B. Quinn, Michael J., Jr. Wallace, Shannon M. TI Assessment of the in vivo genotoxicity of isomers of dinitrotoluene using the alkaline Comet and peripheral blood micronucleus assays SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS LA English DT Article DE Peripheral blood micronucleus assay; Comet assay; Dinitrotoluene; Genotoxicity ID COLLABORATIVE STUDY-GROUP; MUTAGENICITY STUDY-GROUP; MOUSE BONE-MARROW; UNSCHEDULED DNA-SYNTHESIS; STUDY-GROUP MMS; SALMONELLA-TYPHIMURIUM; RAT HEPATOCYTES; LIVER; CELLS; INVIVO AB Dinitrotoluene (DNT) is a nitroaromatic explosive that exists as six isomers; two major isomers (2,4- and 2,6-DNT) and four minor isomers (2,3-, 2,5-, 3,4-, and 3,5-DNT). DNT has been found in soil, surface water, and groundwater near ammunition production plants. The major isomers of DNT are classified as "likely to cause cancer in humans." In vitro studies have provided conflicting data regarding the genotoxicity of the minor isomers. Studies indicate that metabolism in the gut and liver are necessary to convert DNT to genotoxic compounds. As such, in the present study the genotoxicity of isomers of DNT was assessed using two in vivo genotoxicity assays. The Comet assay was used to detect DNA damage in liver cells from male Sprague-Dawley rats following oral exposure (14-day) to individual isomers of DNT. The micronucleus assay was conducted using flow cytometric analysis to detect chromosomal damage in peripheral blood. Treatment with 2,3-, 3,4-, 2,4-, 2,5- and 3,5-DNT did not induce DNA damage in liver cells or increase the frequency of micronucleated reticulocytes (MN-RET) in peripheral blood at the doses tested. Treatment with 2,6-DNT induced DNA damage in liver tissue at all doses tested, but did not increase the frequency of micronucleated reticulocytes (MN-RET) in peripheral blood. Thus, 2,4-DNT and the minor isomers were not genotoxic under these test conditions, while 2,6-DNT was genotoxic in the target tissue, the liver. These results support previous research which indicated that the hepatocarcinogenicity of technical grade DNT (TG-DNT) could be attributed to the 2,6-DNT isomer. Published by Elsevier B.V. C1 [Lent, Emily May; Crouse, Lee C. B.; Quinn, Michael J., Jr.; Wallace, Shannon M.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21050 USA. RP Lent, EM (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21050 USA. EM emily.m.lent@us.army.mil FU U.S. Army Environmental Center FX This work was funded by the U.S. Army Environmental Center Installation Restoration Program. The authors gratefully acknowledge the following people for the assistance: Matt Bazar, Patricia Beall, Shenell Bolden, LTC Kenneth Despain, Mike Hable, Terry Hanna, John Houpt, Craig McFarland, Will McCain, Curtis Oliver, Arthur O'Neill, and Mark Way. NR 38 TC 6 Z9 8 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1383-5718 J9 MUTAT RES-GEN TOX EN JI Mutat. Res. Genet. Toxicol. Environ. Mutagen. PD FEB 18 PY 2012 VL 742 IS 1-2 BP 54 EP 60 DI 10.1016/j.mrgentox.2011.11.013 PG 7 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology GA 900AB UT WOS:000300857900009 PM 22155124 ER PT J AU Zhang, X Nakahara, Y Xuan, D Wu, D Zhao, FK Li, XY Zhang, JS AF Zhang, Xu Nakahara, Yukiko Xuan, Dwight Wu, Di Zhao, Fang-Kun Li, Xiao-Yan Zhang, Jin-Song TI Study on the optical property and biocompatibility of a tissue engineering cornea SO INTERNATIONAL JOURNAL OF OPHTHALMOLOGY LA English DT Article DE Tissue engineering; Collagen cross-linking scaffold; Primary culture in vitro; Optical property; Biocompatibility ID SURFACE MODIFICATION; ARTIFICIAL CORNEA; EPITHELIAL-CELLS; CROSS-LINKING; COLLAGEN; MATRIX; RECONSTRUCTION; CULTURE; DIFFERENTIATION; REGENERATION AB AIM: To study the optical property and biocompatibility of a tissue engineering cornea. METHODS: The cross-linker of N- (3-Dimethylaminoropyl)-N'ethylcarbodiimide hydrochloride (EDC)/ N-Hydroxysuccinimide (NHS) was mixed with Type I collagen at 10% (weight/volume). The final solution was molded to the shape of a corneal contact lens. The collagen concentrations of 10%, 12.5%, 15%, 17.5% and 20% artificial corneas were tested by UV/vis-spectroscopy for their transparency compared with normal rat cornea. 10-0 sutures were knotted on the edges of substitute to measure the corneal buttons's mechanical properties. Normal rat corneal tissue primary culture on the collagen scaffold was observed in 4 weeks. Histopathologic examinations were performed after 4 weeks of in vitro culturing. RESULTS: The collagen scaffold appearance was similar to that of soft contact lens. With the increase of collagen concentration, the transparency of artificial corneal buttons was diminished, but the toughness of the scaffold was enhanced. The scaffold transparency in the 10% concentration collagen group resembled normal rat cornea. To knot and embed the scaffold under the microscope, 20% concentration collagen group was more effective during implantation than lower concentrations of collagen group. In the first 3 weeks, corneal cell proliferation was highly active. The shapes of cells that grew on the substitute had no significant difference when compared with the cells before they were moved to the scaffold. However, on the fortieth day, most cells detached from the scaffold and died. Histopathologic examination of the primary culture scaffold revealed well grown corneal cells tightly attached to the scaffold in the former culturing. CONCLUSION: Collagen scaffold can be molded to the shape of soft contact corneal lens with NHS/EDC. The biological stability and biocompatibility of collagen from animal species may be used as material in preparing to engineer artificial corneal scaffold. C1 [Zhang, Xu; Wu, Di; Zhao, Fang-Kun; Li, Xiao-Yan; Zhang, Jin-Song] China Med Univ, Affiliated Hosp 4, Dept Ophthalmol, Eye Hosp,Prov Key Lab Lens Res, Shenyang 110005, Liaoning Provin, Peoples R China. [Nakahara, Yukiko] Junshin Gakuen Univ, Dept Med Engn, Fac Hlth Sci, Fukuoka 8158510, Japan. [Xuan, Dwight] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Li, XY (reprint author), China Med Univ, Affiliated Hosp 4, Dept Ophthalmol, Eye Hosp,Prov Key Lab Lens Res, Shenyang 110005, Liaoning Provin, Peoples R China. EM cmu4h_lxy@126.com NR 34 TC 0 Z9 0 U1 2 U2 16 PU IJO PRESS PI XI AN PA NO 269 YOUYI EAST RD, XI AN, 710054, PEOPLES R CHINA SN 2222-3959 J9 INT J OPHTHALMOL-CHI JI Int. J. Ophthalmol. PD FEB 18 PY 2012 VL 5 IS 1 BP 45 EP 49 DI 10.3980/j.issn.2222-3959.2012.01.09 PG 5 WC Ophthalmology SC Ophthalmology GA 895ZD UT WOS:000300534300009 PM 22553753 ER PT J AU Gibbons, HS Krepps, MD Ouellette, G Karavis, M Onischuk, L Leonard, P Broomall, S Sickler, T Betters, JL McGregor, P Donarum, G Liem, A Fochler, E Mcnew, L Rosenzweig, CN Skowronski, E AF Gibbons, Henry S. Krepps, Michael D. Ouellette, Gary Karavis, Mark Onischuk, Lisa Leonard, Pascale Broomall, Stacey Sickler, Todd Betters, Janet L. McGregor, Paul Donarum, Greg Liem, Alvin Fochler, Ed Mcnew, Lauren Rosenzweig, C. Nicole Skowronski, Evan TI Comparative Genomics of 2009 Seasonal Plague (Yersinia pestis) in New Mexico SO PLOS ONE LA English DT Article ID PHYLOGENETIC ANALYSIS; TANDEM REPEATS; DRAFT GENOME; PERSISTENCE; ORIENTALIS; DIVERSITY; EVOLUTION; SEQUENCE; AGENT; SOIL AB Plague disease caused by the Gram-negative bacterium Yersinia pestis routinely affects animals and occasionally humans, in the western United States. The strains native to the North American continent are thought to be derived from a single introduction in the late 19th century. The degree to which these isolates have diverged genetically since their introduction is not clear, and new genomic markers to assay the diversity of North American plague are highly desired. To assay genetic diversity of plague isolates within confined geographic areas, draft genome sequences were generated by 454 pyrosequencing from nine environmental and clinical plague isolates. In silico assemblies of Variable Number Tandem Repeat (VNTR) loci were compared to laboratory-generated profiles for seven markers. High-confidence SNPs and small Insertion/Deletions (Indels) were compared to previously sequenced Y. pestis isolates. The resulting panel of mutations allowed clustering of the strains and tracing of the most likely evolutionary trajectory of the plague strains. The sequences also allowed the identification of new putative SNPs that differentiate the 2009 isolates from previously sequenced plague strains and from each other. In addition, new insertion points for the abundant insertion sequences (IS) of Y. pestis are present that allow additional discrimination of strains; several of these new insertions potentially inactivate genes implicated in virulence. These sequences enable whole-genome phylogenetic analysis and allow the unbiased comparison of closely related isolates of a genetically monomorphic pathogen. C1 [Gibbons, Henry S.; Krepps, Michael D.; Ouellette, Gary; Karavis, Mark; Broomall, Stacey; Sickler, Todd; Betters, Janet L.; McGregor, Paul; Mcnew, Lauren; Rosenzweig, C. Nicole; Skowronski, Evan] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Ouellette, Gary; McGregor, Paul] Sci Applicat Int Corp, Aberdeen Proving Ground, MD USA. [Onischuk, Lisa; Leonard, Pascale] New Mexico Dept Publ Hlth, Albuquerque, NM USA. [Donarum, Greg; Liem, Alvin; Fochler, Ed] OptiMetrics Inc, Abingdon, MD USA. [Krepps, Michael D.] Excet Inc, Springfield, VA USA. RP Gibbons, HS (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. EM henry.gibbons.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [CB2847]; New Mexico Department of Health FX The work presented here was supported by the Defense Threat Reduction Agency (DTRA) under project number CB2847 to HSG, CNR, and ES and by the New Mexico Department of Health to LO and PL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 5 Z9 5 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 16 PY 2012 VL 7 IS 2 AR e31604 DI 10.1371/journal.pone.0031604 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 925XS UT WOS:000302796200074 PM 22359605 ER PT J AU Saguil, A Fargo, M AF Saguil, Aaron Fargo, Matthew TI Acute Respiratory Distress Syndrome: Diagnosis and Management SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID ACUTE LUNG INJURY; INTENSIVE-CARE-UNIT; QUALITY-OF-LIFE; FUNCTIONAL DISABILITY; PULMONARY-ARTERY; SEVERE SEPSIS; OUTCOMES; METAANALYSIS; SURVIVORS; FAILURE AB Acute respiratory distress syndrome manifests as rapidly progressive dyspnea, tachypnea, and hypoxemia. Diagnostic criteria include acute onset, profound hypoxemia, bilateral pulmonary infiltrates, and the absence of left atrial hypertension. Acute respiratory distress syndrome is believed to occur when a pulmonary or extrapulmonary insult causes the release of inflammatory mediators, promoting neutrophil accumulation in the microcirculation of the lung. Neutrophils damage the vascular endothelium and alveolar epithelium, leading to pulmonary edema, hyaline membrane formation, decreased lung compliance, and difficult air exchange. Most cases of acute respiratory distress syndrome are associated with pneumonia or sepsis. It is estimated that 7.1 percent of all patients admitted to an intensive care unit and 16.1 percent of all patients on mechanical ventilation develop acute lung injury or acute respiratory distress syndrome. In-hospital mortality related to these conditions is between 34 and 55 percent, and most deaths are due to multiorgan failure. Acute respiratory distress syndrome often has to be differentiated from congestive heart failure, which usually has signs of fluid overload, and from pneumonia. Treatment of acute respiratory distress syndrome is supportive and includes mechanical ventilation, prophylaxis for stress ulcers and venous thromboembolism, nutritional support, and treatment of the underlying injury. Low tidal volume, high positive end-expiratory pressure, and conservative fluid therapy may improve outcomes. A spontaneous breathing trial is indicated as the patient improves and the underlying illness resolves. Patients who survive acute respiratory distress syndrome are at risk of diminished functional capacity, mental illness, and decreased quality of life; ongoing care by a primary care physician is beneficial for these patients. (Am Fam Physician. 2012;85(4):352-358. Copyright (C) 2012 American Academy of Family Physicians.) C1 [Saguil, Aaron] Ft Belvoir Community Hosp Family Med Residency, Ft Belvoir, VA 22060 USA. [Fargo, Matthew] Dwight D Eisenhower Army Med Ctr Family Med Resid, Ft Gordon, GA USA. RP Saguil, A (reprint author), Ft Belvoir Community Hosp, 9300 DeWitt Loop, Ft Belvoir, VA 22060 USA. EM asaguil@usuhs.mil NR 48 TC 15 Z9 18 U1 0 U2 6 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 15 PY 2012 VL 85 IS 4 BP 352 EP 358 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980AZ UT WOS:000306867300009 PM 22335314 ER PT J AU Bode, D Seehusen, DA Baird, D AF Bode, David Seehusen, Dean A. Baird, Drew TI Hirsutism in Women SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID POLYCYSTIC-OVARY-SYNDROME; PILOSEBACEOUS UNIT; ANDROGEN EXCESS; HAIR-GROWTH; HYPERANDROGENISM; METAANALYSES; PREVALENCE; EXPERIENCE; ACNE AB Hirsutism is excess terminal hair that commonly appears in a male pattern in women. Although hirsutism is generally associated with hyperandrogenemia, one-half of women with mild symptoms have normal androgen levels. The most common cause of hirsutism is polycystic ovary syndrome, accounting for three out of every four cases. Many medications can also cause hirsutism. In patients whose hirsutism is not related to medication use, evaluation is focused on testing for endocrinopathies and neoplasms, such as polycystic ovary syndrome, adrenal hyperplasia, thyroid dysfunction, Cushing syndrome, and androgen-secreting tumors. Symptoms and findings suggestive of neoplasm include rapid onset of symptoms, signs of virilization, and a palpable abdominal or pelvic mass. Patients without these findings who have mild symptoms and normal menses can be treated empirically. For patients with moderate or severe symptoms, an early morning total testosterone level should be obtained, and if moderately elevated, it should be followed by a plasma free testosterone level. A total testosterone level greater than 200 ng per dL (6.94 nmol per L) should prompt evaluation for an androgen-secreting tumor. Further workup is guided by history and physical examination, and may include thyroid function tests, prolactin level, 17-hydroxyprogesterone level, and corticotropin stimulation test. Treatment includes hair removal and pharmacologic measures. Shaving is effective but needs to be repeated often. Evidence for the effectiveness of electrolysis and laser therapy is limited. In patients who are not planning a pregnancy, first-line pharmacologic treatment should include oral contraceptives. Topical agents, such as eflornithine, may also be used. Treatment response should be monitored for at least six months before making adjustments. (Am Fam Physician. 2012;85(4):373-380. Copyright (C) 2012 American Academy of Family Physicians.) C1 [Bode, David] Brooke Army Med Ctr, Dept Adolescent Med, Ft Sam Houston, TX 78234 USA. [Seehusen, Dean A.] Ft Belvoir Community Hosp, Family Med Residency Program, Ft Belvoir, VA USA. [Baird, Drew] Carl R Darnall Army Med Ctr, Ft Hood, TX USA. RP Bode, D (reprint author), Brooke Army Med Ctr, Dept Adolescent Med, 3100 Schofield Rd,Bldg 1179, Ft Sam Houston, TX 78234 USA. EM dave.bode@us.army.mil NR 26 TC 12 Z9 15 U1 0 U2 3 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 15 PY 2012 VL 85 IS 4 BP 373 EP 380 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980AZ UT WOS:000306867300010 PM 22335316 ER PT J AU George, SZ Childs, JD Teyhen, DS Wu, SS Wright, AC Dugan, JL Robinson, ME AF George, Steven Z. Childs, John D. Teyhen, Deydre S. Wu, Samuel S. Wright, Alison C. Dugan, Jessica L. Robinson, Michael E. TI Predictors of Occurrence and Severity of First Time Low Back Pain Episodes: Findings from a Military Inception Cohort SO PLOS ONE LA English DT Article ID BECK DEPRESSION INVENTORY; CORE STABILIZATION EXERCISES; RANDOMIZED CLINICAL-TRIAL; RISK-FACTORS; FOLLOW-UP; PSYCHOSOCIAL EDUCATION; SUBGROUPING PATIENTS; SCIENTIFIC EVIDENCE; PRIMARY PREVENTION; DISABILITY BEGINS AB Primary prevention studies suggest that additional research on identifying risk factors predictive of low back pain (LBP) is necessary before additional interventions can be developed. In the current study we assembled a large military cohort that was initially free of LBP and followed over 2 years. The purposes of this study were to identify baseline variables from demographic, socioeconomic, general health, and psychological domains that were predictive of a) occurrence; b) time; and c) severity for first episode of self-reported LBP. Baseline and outcome measures were collected via web-based surveillance system or phone to capture monthly information over 2 years. The assembled cohort consisted of 1230 Soldiers who provided self-report data with 518 (42.1%) reporting at least one episode of LBP over 2 years. Multivariate logistic regression analysis indicated that gender, active duty status, mental and physical health scores were significant predictors of LBP. Cox regression revealed that the time to first episode of LBP was significantly shorter for Soldiers that were female, active duty, reported previous injury, and had increased BMI. Multivariate linear regression analysis investigated severity of the first episode by identifying baseline predictors of pain intensity, disability, and psychological distress. Education level and physical fitness were consistent predictors of pain intensity, while gender, smoking status, and previous injury status were predictors of disability. Gender, smoking status, physical health scores, and beliefs of back pain were consistent predictors of psychological distress. These results provide additional data to confirm the multi-factorial nature of LBP and suggest future preventative interventions focus on multi-modal approaches that target modifiable risk factors specific to the population of interest. C1 [George, Steven Z.] Univ Florida, Dept Phys Therapy, Gainesville, FL 32610 USA. [George, Steven Z.; Robinson, Michael E.] Univ Florida, Ctr Pain Res & Behav Hlth, Gainesville, FL USA. [Childs, John D.; Teyhen, Deydre S.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HGE PT, Army Med Dept Ctr, Ft Sam Houston, TX USA. [Wu, Samuel S.] Univ Florida, Dept Biostat, Gainesville, FL USA. [Robinson, Michael E.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL USA. RP George, SZ (reprint author), Univ Florida, Dept Phys Therapy, Gainesville, FL 32610 USA. EM szgeorge@phhp.ufl.edu FU Department of Defense [PR054098]; University of Florida FX The POLM trial was supported by the Peer-Review Medical Research Program of the Department of Defense (PR054098). All authors were independent from this funding program. Publication of this article was funded in part by the University of Florida Open-Access Publishing Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 51 TC 11 Z9 11 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 15 PY 2012 VL 7 IS 2 AR e30597 DI 10.1371/journal.pone.0030597 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 925DP UT WOS:000302741300017 PM 22355317 ER PT J AU Hollingshad, NW Turalska, M Allegrini, P West, BJ Grigolini, P AF Hollingshad, Nicholas W. Turalska, Malgorzata Allegrini, Paolo West, Bruce J. Grigolini, Paolo TI A new measure of network efficiency SO PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS LA English DT Article DE Network ID SCALE-FREE NETWORKS; COMPLEX NETWORKS; DYNAMICS; MODEL AB We address the issue of the dynamical origin of scale-free link distributions. We study a two-dimensional lattice of cooperatively interacting units. Although the units interact only with the four nearest neighbors, a sufficiently large cooperation strength generates dynamically a scale-free network with the power law index v approaching 1. We explain this result by using a new definition of network efficiency determined by the Euclidean distance between correlated units. According to this definition the link distribution favoring long-range connections makes efficiency increase. We embed an ad hoc scale-free network with power index nu >= 1 into a Euclidean two-dimensional space and show that the network efficiency becomes maximal as nu approaches 1. We therefore conclude that nu = 1 emerging from the cooperative interaction of units may be a consequence of the principle of network maximal efficiency. (C) 2011 Elsevier B.V. All rights reserved. C1 [Hollingshad, Nicholas W.; Turalska, Malgorzata; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Allegrini, Paolo] Ist Fisiol Clin IFC CNR, I-56124 Pisa, Italy. [West, Bruce J.] USA, Informat Sci Directorate, Res Off, Durham, NC 27709 USA. RP Hollingshad, NW (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA. EM nwh0012@unt.edu RI Allegrini, Paolo/C-1876-2012 OI Allegrini, Paolo/0000-0002-5476-9005 NR 26 TC 3 Z9 3 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4371 J9 PHYSICA A JI Physica A PD FEB 15 PY 2012 VL 391 IS 4 BP 1894 EP 1899 DI 10.1016/j.physa.2011.11.017 PG 6 WC Physics, Multidisciplinary SC Physics GA 894XB UT WOS:000300459700095 ER PT J AU Roedel, EQ Cafasso, DE Lee, KWM Pierce, LM AF Roedel, Erik Q. Cafasso, Danielle E. Lee, Karen W. M. Pierce, Lisa M. TI Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Tungsten alloy; Pulmonary toxicity; Inflammation; Lung macrophage; Gene expression; Oxidative burst ID NF-KAPPA-B; DEPLETED URANIUM; IN-VIVO; OXIDATIVE STRESS; REACTIVE OXYGEN; TRANSCRIPTIONAL REGULATION; CARBIDE PARTICLES; NUCLEAR FACTOR-1; COBALT; EXPRESSION AB Significant controversy over the environmental and public health impact of depleted uranium use in the Gulf War and the war in the Balkans has prompted the investigation and use of other materials including heavy metal tungsten alloys (HMTAs) as nontoxic alternatives. Interest in the health effects of HMTAs has peaked since the recent discovery that rats intramuscularly implanted with pellets containing 91.1% tungsten/6% nickel/2.9% cobalt rapidly developed aggressive metastatic tumors at the implantation site. Very little is known, however, regarding the cellular and molecular mechanisms associated with the effects of inhalation exposure to HMTAs despite the recognized risk of this route of exposure to military personnel. In the current study military-relevant metal powder mixtures consisting of 92% tungsten/5% nickel/3% cobalt (WNiCo) and 92% tungsten/5% nickel/3% iron (WNiFe), pure metals, or vehicle (saline) were instilled intratracheally in rats. Pulmonary toxicity was assessed by cytologic analysis, lactate dehydrogenase activity, albumin content, and inflammatory cytokine levels in bronchoalveolar lavage fluid 24 h after instillation. The expression of 84 stress and toxicity-related genes was profiled in lung tissue and bronchoalveolar lavage cells using realtime quantitative PCR arrays, and in vitro assays were performed to measure the oxidative burst response and phagocytosis by lung macrophages. Results from this study determined that exposure to WNiCo and WNiFe induces pulmonary inflammation and altered expression of genes associated with oxidative and metabolic stress and toxicity. Inhalation exposure to both HMTAs likely causes lung injury by inducing macrophage activation, neutrophilia, and the generation of toxic oxygen radicals. Published by Elsevier Inc. C1 [Lee, Karen W. M.; Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. [Roedel, Erik Q.; Cafasso, Danielle E.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Erik.Roedel@amedd.army.mil; Danielle.Cafasso@amedd.army.mil; Karen.W.Lee@amedd.army.mil; Lisa.Pierce@amedd.army.mil RI Osborne, Nicholas/N-4915-2015 OI Osborne, Nicholas/0000-0002-6700-2284 FU Defense Medical Research and Development Program FX This work was funded by a Defense Medical Research and Development Program grant awarded to LP. The sponsor had no involvement in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the paper for publication. We thank Lee-Ann Murata and Claudia Hernandez for technical assistance with some of the BAL fluid assays. NR 55 TC 12 Z9 12 U1 2 U2 23 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD FEB 15 PY 2012 VL 259 IS 1 BP 74 EP 86 DI 10.1016/j.taap.2011.12.008 PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 903CY UT WOS:000301094800008 PM 22198552 ER PT J AU Mancuso, JD Mazurek, GH Tribble, D Olsen, C Aronson, NE Geiter, L Goodwin, D Keep, LW AF Mancuso, James D. Mazurek, Gerald H. Tribble, David Olsen, Cara Aronson, Naomi E. Geiter, Lawrence Goodwin, Donald Keep, Lisa W. TI Discordance among Commercially Available Diagnostics for Latent Tuberculosis Infection SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article DE tuberculosis screening; interferon-gamma release assays; nontuberculous mycobacteria ID GAMMA RELEASE ASSAYS; RISK ASSESSMENT QUESTIONNAIRE; SKIN-TEST ANTIGENS; MYCOBACTERIUM-TUBERCULOSIS; UNITED-STATES; CHILDREN; TESTS; PREVALENCE; DISEASE; TB AB Rationale: There is uncertainty regarding how to interpret discordance between tests for latent tuberculosis infection. Objectives: The objective of this study was to assess discordance between commercially available tests for latent tuberculosis in a low-prevalence population, including the impact of nontuberculous mycobacteria. Methods: This was a cross-sectional comparison study among 2,017 military recruits at Fort Jackson, South Carolina, from April to June 2009. Several tests were performed simultaneously with a risk factor questionnaire, including (1) QuantiFERON-TB Gold In-Tube test, (2) T-SPOT. TB test, (3) tuberculin skin test, and (4) Battey skin test using purified protein derivative from the Battey bacillus. Measurements and Main Results: In this low-prevalence population, the specificities of the three commercially available diagnostic tests were not significantly different. Of the 88 subjects with a positive test, only 10 (11.4%) were positive to all three tests; 20 (22.7%) were positive to at least two tests. Bacille Calmette-Guerin vaccination, tuberculosis prevalence in country of birth, and Battey skin test reaction size were associated with tuberculin skin test-positive, IFN-gamma release assay-negative test discordance. Increasing agreement between the three tests was associated with epidemiologic criteria indicating risk of infection and with quantitative test results. Conclusions: For most positive results the three tests identified different people, suggesting that in low-prevalence populations most discordant results are caused by false-positives. False-positive tuberculin skin test reactions associated with reactivity to nontuberculous mycobacteria and bacille Calmette-Guerin vaccination may account for a proportion of test discordance observed. C1 [Mancuso, James D.] Walter Reed Army Inst Res, Prevent Med Residency Program, Div Prevent Med, Silver Spring, MD 20910 USA. [Mazurek, Gerald H.] Ctr Dis Control & Prevent, Div TB Eliminat, Atlanta, GA USA. [Mancuso, James D.; Tribble, David; Olsen, Cara; Keep, Lisa W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Aronson, Naomi E.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Geiter, Lawrence] Otsuka Pharmaceut Co Ltd, TB Prod Unit, Rockville, MD USA. [Goodwin, Donald] USAF, Sch Aerosp Med, Wright Patterson AFB, OH 45433 USA. RP Mancuso, JD (reprint author), Walter Reed Army Inst Res, Prevent Med Residency Program, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM james.mancuso@us.army.mil FU Department of Defense through the Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Supported by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The content of this publication is the sole responsibility of the authors and does not necessarily reflect the views or policies of the NIH, the Department of Health and Human Services, the Centers for Disease Control and Prevention, the Department of Defense, or the Departments of the Army, Navy, or Air Force. Mention of trade names, commercial products, or organizations does not imply endorsement by the US Government. The Infectious Disease Clinical Research Program (Bethesda, MD) participated in all phases of the study, including design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Oxford Immunotec (Marlborough, MA) performed T-Spot testing (masked) as an in-kind contribution, but played no other role in the design, conduct, collection, management, analysis, interpretation of the data, preparation, review, or approval of the manuscript. Laboratory and technical support was also provided by the US Air Force School of Aerospace Medicine and the Centers for Disease Control and Prevention's Division of TB Elimination. NR 45 TC 31 Z9 32 U1 0 U2 3 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD FEB 15 PY 2012 VL 185 IS 4 BP 427 EP 434 DI 10.1164/rccm.201107-1244OC PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 897EY UT WOS:000300629900015 PM 22161162 ER PT J AU Chen, BW Shah, SS Shin, Y Lei, CH Liu, J AF Chen, Baowei Shah, Saumil S. Shin, Yongsoon Lei, Chenghong Liu, Jun TI In vitro release of organophosphorus acid anhydrolase from functionalized mesoporous silica against nerve agents SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE Controlled release; Organophosphorus acid anhydrolase; Mesoporous silica; Organophosphorus nerve agents ID CATALYTIC ACTIVITY; ENZYME; ACETYLCHOLINESTERASE; DECONTAMINATION; CONFINEMENT; SUPPORTS AB We report here that under different physiological conditions, biomolecular drugs can be stockpiled in a nanoporous support and afterward can be instantly released when needed for acute responses, and the biomolecular drug molecules can also be gradually released from the nanoporous support over a long time for a complete recovery. Organophosphorus acid anhydrolase (OPAA) was spontaneously and largely entrapped in functionalized mesoporous silica (FMS) due to the dominant electrostatic interaction. The OPAA-FMS composite exhibited a burst release in a pH 9.0 NaHCO3-Na2CO3 buffer system and a gradual release in pH 7.4 simulated body fluid. The binding of OPAA to NH2-FMS can result in less tyrosinyl and tryptophanyl exposure OPAA molecules to aqueous environment. The bound OPAA in FMS displayed lower activity than the free OPAA in solution prior to the enzyme entrapment. However, the released enzyme maintained the native conformational structure and the same high enzymatic activity as that prior to the enzyme entrapment. The in vitro results in the rabbit serum demonstrate that both OPAA-FMS and the released OPAA may be used as a medical countermeasure against the organophosphorus nerve agents. (C) 2011 Elsevier Inc. All rights reserved. C1 [Chen, Baowei; Shin, Yongsoon; Lei, Chenghong; Liu, Jun] Pacific NW Natl Lab, Richland, WA 99352 USA. [Shah, Saumil S.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Lei, CH (reprint author), Pacific NW Natl Lab, Richland, WA 99352 USA. EM chenghong.lei@pnl.gov FU National Institutes of Health (NIH); National Institute of General Medical Sciences [R01GM080987]; office of Basic Energy Sciences of the U.S. Department of Energy [KC020105-FWP12152]; Transformational Materials Science Initiative of the Pacific Northwest National Laboratory (PNNL); Battelle [DE-AC06-RLO1830] FX This work was supported by the National Institutes of Health (NIH), National Institute of General Medical Sciences (grant R01GM080987), the office of Basic Energy Sciences of the U.S. Department of Energy (award KC020105-FWP12152), and the Transformational Materials Science Initiative of the Pacific Northwest National Laboratory (PNNL). PNNL is operated for the U.S. Department of Energy by Battelle under contract DE-AC06-RLO1830. NR 18 TC 5 Z9 5 U1 1 U2 22 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD FEB 15 PY 2012 VL 421 IS 2 BP 477 EP 481 DI 10.1016/j.ab.2011.09.024 PG 5 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 895WW UT WOS:000300528400017 PM 22019765 ER PT J AU Okusaga, O Cahill, J Docherty, A Zhou, W Menyuk, CR AF Okusaga, O. Cahill, J. Docherty, A. Zhou, W. Menyuk, C. R. TI Guided entropy mode Rayleigh scattering in optical fibers SO OPTICS LETTERS LA English DT Article ID FREQUENCY AB Rayleigh scattering in optical fibers has the potential to degrade the performance of low-noise opto-electronic systems. In this Letter, we measure the Rayleigh gain spectrum of optical fibers. Our data show the gain bandwidth and the offset frequency of the Rayleigh gain peak. Both the gain bandwidth and the peak frequency are 3 orders of magnitude lower than the corresponding values for bulk silica. Our data suggest that the narrower gain bandwidth and frequency shift that we observe are due to guided entropy modes in the fiber. This effect is fundamental and will be present in any medium in which light is guided so that transverse intensity gradients exist. (C) 2012 Optical Society of America C1 [Okusaga, O.; Cahill, J.; Zhou, W.] USA, Res Lab, Adelphi, MD 20873 USA. [Cahill, J.; Docherty, A.; Menyuk, C. R.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA. RP Okusaga, O (reprint author), USA, Res Lab, Adelphi, MD 20873 USA. EM olukayode.k.okusaga.civ@mail.mil NR 8 TC 14 Z9 14 U1 1 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD FEB 15 PY 2012 VL 37 IS 4 BP 683 EP 685 PG 3 WC Optics SC Optics GA 898AF UT WOS:000300706500080 PM 22344147 ER PT J AU Brimfield, AA Soni, SD Trimmer, KA Zottola, MA Sweeney, RE Graham, JS AF Brimfield, A. A. Soni, S. D. Trimmer, K. A. Zottola, M. A. Sweeney, R. E. Graham, J. S. TI Metabolic activation of sulfur mustard leads to oxygen free radical formation SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Article DE Sulfur mustard; Mechanism; Free radical; Redox cycling; Reactive oxygen species ID LIPID-PEROXIDATION; REDUCTASE; PARAQUAT; MECHANISM; SYSTEMS AB We recently published electron paramagnetic resonance (EPR) spin trapping results that demonstrated the enzymatic reduction of sulfur mustard sulfonium ions to carbon-based free radicals using an in vitro system containing sulfur mustard, cytochrome P450 reductase, NADPH, and the spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (4-POBN) in buffer (A.A. Brimfield et al., 2009, Toxicol. Appl. Pharmacol. 234:128-134). Carbon-based radicals have been shown to reduce molecular oxygen to form superoxide and, subsequently, peroxyl and hydroxyl radicals. In some cases, such as with the herbicide paraquat, a cyclic redox system results, leading to magnified oxygen free radical concentration and sustained tissue damage. Low mustard carbon radical concentrations recorded by EPR in our in vitro system, despite a robust (4.0 mM) sulfur mustard starting concentration, led us to believe a similar oxygen reduction and redox cycling process might be involved with sulfur mustard. A comparison of the rate of mustard radical-POBN adduct formation in our in vitro system by EPR at atmospheric and reduced oxygen levels indicated a sixfold increase in 4-POBN adduct formation (0.5 to 3.0 mu M) at the reduced oxygen concentration. That result suggested competition between oxygen and POBN for the available carbon-based mustard radicals. In parallel experiments we found that the oxygen radical-specific spin trap 5-tert-butoxycarbonyl-5-methylpyrroline-N-oxide (BMPO) detected peroxyl and hydroxyl radicals directly when it was used in place of POBN in the in vitro system. Presumably these radicals originated from 02 reduced by carbon-based mustard radicals. We also showed that reactive oxygen species (ROS)-BMPO EPR signals were reduced or eliminated when mustard carbon radical production was impeded by systematically removing system components, indicating that carbon radicals were a necessary precursor to ROS production. ROS EPR signals were completely eliminated when superoxide dismutase and catalase were included in the complete in vitro enzymatic system, providing additional proof of oxygen radical participation. The redox cycling hypothesis was supported by density functional theory calculations and frontier molecular orbital analysis. Published by Elsevier Inc. C1 [Brimfield, A. A.; Soni, S. D.; Trimmer, K. A.; Sweeney, R. E.] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. [Zottola, M. A.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. [Graham, J. S.] USA, Med Res Inst Chem Def, Off Commander, Aberdeen Proving Ground, MD 21010 USA. RP Brimfield, AA (reprint author), USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. EM Alan.A.Brimfield@us.army.mil OI Trimmer, Kenneth/0000-0003-2161-4645 FU U.S. Army Medical Research Institute of Chemical Defense [Y1-A1-6177-03]; NIH/NIAID [Y1-A1-6177-03]; Defense Threat Reduction Agency [2.A0008-05-RC-PP-C] FX This work was supported by Interagency Agreement Y1-A1-6177-03, Chemicals Affecting the Skin, Eyes and Mucous Membranes-Toxic Vesicants and Industrial Chemicals, between the U.S. Army Medical Research Institute of Chemical Defense and the NIH/NIAID and by Defense Threat Reduction Agency Project 2.A0008-05-RC-PP-C, Biochemical Reduction of Sulfonium Ions in the Toxicity of Sulfur Mustard. Thanks to Dr. Betty Sue Masters of the Department of Biochemistry, University of Texas Health Sciences Center (San Antonio, TX, USA) for the kind gift of recombinant porcine NADPH-cytochrome P450 reductase and to the Alabama Supercomputer Center (Huntsville, AL, USA) for access to their computational resources. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of the Army, the Department of Defense, or the U.S. Government. NR 23 TC 9 Z9 10 U1 0 U2 17 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0891-5849 J9 FREE RADICAL BIO MED JI Free Radic. Biol. Med. PD FEB 15 PY 2012 VL 52 IS 4 BP 811 EP 817 DI 10.1016/j.freeradbiomed.2011.11.031 PG 7 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 886OF UT WOS:000299863000011 PM 22206978 ER PT J AU Peterson, GW Rossin, JA AF Peterson, Gregory W. Rossin, Joseph A. TI Removal of Chlorine Gases from Streams of Air Using Reactive Zirconium Hydroxide Based Filtration Media SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID PERFORMANCE; SUBSTRATE; PHOSGENE; OXIDE AB Zirconium hydroxide and zirconium hydroxide impregnated with triethylenediamine (TEDA) were evaluated for their ability to remove toxic chlorine gases, namely Cl-2, COCl2, and HCl from streams of air in respirator applications. Zirconium hydroxide displayed a high capacity for the removal of HCl; however, the ability of zirconium hydroxide to remove Cl-2 and COCl2 was relatively low. The removal of Cl-2 and COCl2 greatly improved upon impregnation of zirconium hydroxide with TEDA. The improved performance was attributed to the ability of TEDA to promote the hydrolysis of Cl-2 and COCl2, leading to the formation of HCl which was subsequently removed via reaction with hydroxyl groups associated with zirconium hydroxide. XPS analysis revealed the presence of both terminal and bridging hydroxyl groups associated with zirconium hydroxide, with only the terminal hydroxyl groups participating in the removal of reactant or reaction product HCl. C1 [Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43016 USA. [Peterson, Gregory W.] USA, Edgewood Chem Biol Ctr, RDCB DRP F, Aberdeen Proving Ground, MD 21010 USA. RP Rossin, JA (reprint author), Guild Associates Inc, 5750 Shier Rings Rd, Dublin, OH 43016 USA. EM jarossin@guildassociates.com FU Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) [BA07PRO104] FX The authors thank the Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) for funding this work under Project No. BA07PRO104. NR 16 TC 10 Z9 10 U1 1 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD FEB 15 PY 2012 VL 51 IS 6 BP 2675 EP 2681 DI 10.1021/ie200809r PG 7 WC Engineering, Chemical SC Engineering GA 891JA UT WOS:000300211800022 ER PT J AU Testa, JS Shetty, V Sinnathamby, G Nickens, Z Hafner, J Kamal, S Zhang, XC Jett, M Philip, R AF Testa, James S. Shetty, Vivekananda Sinnathamby, Gomathinayagam Nickens, Zacharie Hafner, Julie Kamal, Shivali Zhang, Xianchao Jett, Marti Philip, Ramila TI Conserved MHC Class I-Presented Dengue Virus Epitopes Identified by Immunoproteomics Analysis Are Targets for Cross-Serotype Reactive T-Cell Response SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SYNTHETIC PEPTIDES; PROTEINS NS3; VACCINES; ANTIBODY; INFECTION; FEVER; LIVE; RECOGNITION; LYMPHOCYTES; CANDIDATE AB Dengue fever and dengue hemorrhagic fever are significant global public health problems, and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potentially severe complications. Live attenuated and subunit vaccine candidates, which are under clinical evaluation, induce primarily an antibody response to the virus and minimal cross-reactive T-cell responses. Currently, there are no available tools to assess protective T-cell responses during infection or after vaccination. In this study, we utilize an immunoproteomics process to uncover novel HLA-A2-specific epitopes derived from dengue virus (DV)-infected cells. These epitopes are conserved, and we report that epitope-specific cytotoxic lymphocytes (CTLs) are cross-reactive against all 4 DV serotypes. These epitopes have potential as new informational and diagnostic tools to characterize T-cell immunity in DV infection and may serve as part of a universal vaccine candidate complementary to current vaccines in trial. C1 [Testa, James S.; Shetty, Vivekananda; Sinnathamby, Gomathinayagam; Nickens, Zacharie; Hafner, Julie; Kamal, Shivali; Philip, Ramila] Immunotope Inc, Penn Biotechnol Ctr, Doylestown, PA 18902 USA. [Zhang, Xianchao] Drexel Univ, Coll Med, Drexel Inst Biotechnol & Virol Res, Dept Microbiol & Immunol, Doylestown, PA USA. [Jett, Marti] Walter Reed Army Inst Res, Dept Mol Pathol, Silver Spring, MD USA. RP Philip, R (reprint author), Immunotope Inc, Penn Biotechnol Ctr, 3805 Old Easton Rd, Doylestown, PA 18902 USA. EM rphilip@immunotope.com FU National Institutes of Health Small Business Innovation Research [1R43AI062177] FX Financial support. This work was supported by the National Institutes of Health Small Business Innovation Research (1R43AI062177). NR 47 TC 12 Z9 13 U1 0 U2 4 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB 15 PY 2012 VL 205 IS 4 BP 647 EP 655 DI 10.1093/infdis/jir814 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 885QU UT WOS:000299795000018 PM 22246683 ER PT J AU Zhang, SS Read, JA AF Zhang, Sheng S. Read, Jeffrey A. TI A new direction for the performance improvement of rechargeable lithium/sulfur batteries SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium/sulfur battery; Sulfur; Polysulfide; Catholyte; Lithium plating ID LI-ION BATTERIES; SULFUR BATTERY; ELECTROCHEMICAL PROPERTIES; GEL ELECTROLYTE; CYCLE PROPERTY; CATHODE; COMPOSITE; DISCHARGE; POLYSULFIDES; CELLS AB In this work we introduce a new direction for the performance improvement of rechargeable lithium/sulfur batteries by employing an electrolyte that promotes Li anode passivation in lithium polysulfide solutions. To examine our concept, we assemble and characterize Li/Li2S9 liquid cells by using a porous carbon electrode as the current collector and a 0.25 m Li2S9 solution as the catholyte. Results show that Li/Li2S9 liquid cells are superior to conventional Li/S cells in specific capacity and capacity retention. We also find that use of LiNO3 as a co-salt in the Li2S9 catholyte significantly increases the cell's Coulombic efficiency. More importantly, the cells with LiNO3 have a similar to 2.5V voltage plateau before the end of charging and demonstrate a steep voltage rise at the end of charging. The former is indicative of the formation of elemental sulfur from soluble lithium polysulfides on the carbon electrode, and the latter provides a distinct signal for full charging. Electrochemical analyses on Li plating and stripping in Li2S9 catholyte solutions indicate that LiNO3 participates in the formation of a highly protective passivation film on the Li metal surface, which effectively prevents the Li anode from chemical reaction with polysulfide anions in the electrolyte and meanwhile prevents polysulfide anions from electrochemical reduction on the Li surface. Published by Elsevier B.V. C1 [Zhang, Sheng S.; Read, Jeffrey A.] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM shengshui.zhang@us.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 31 TC 151 Z9 153 U1 29 U2 279 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD FEB 15 PY 2012 VL 200 BP 77 EP 82 DI 10.1016/j.jpowsour.2011.10.076 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 867OP UT WOS:000298464000011 ER PT J AU Racicot, K Favreau, N Fossey, S Grella, AR Ndou, T Bruno, FF AF Racicot, Kenneth Favreau, Nicole Fossey, Stephen Grella, Alexandra R. Ndou, Tshinanne Bruno, Ferdinando F. TI Antioxidant potency of highly purified polyepicatechin fractions SO FOOD CHEMISTRY LA English DT Article DE Green chemistry; Enzymatic polymerisation; Epicatechin; Horseradish peroxidases ID RADICAL ABSORBENCY CAPACITY; LIPID OXIDATION; PEROXIDASE; ASSAY; POLYMERS; PHENOLS; SAMPLES AB The purpose of this study was to characterise the purified fractions of the novel highly stable polymer polyepicatechin and test them for their antioxidant potency. This paper presents, for the first time, a methodology for separating the fractions for food applications. Polyepicatechin is synthesised, using Green chemistry, through the enzymatic polymerisation, in a water/ethanol mixture of epicatechin (a fiavonol found in green tea). The polyepicatechin, which is entirely different from the natural proanthocyanidin, is soluble in a water/ethanol mixture. The ultimate objective is to increase the thermal stability and antioxidant potency of epicatechin so it can be applied to foods, such as poultry and fish, to reduce their rancidity. UV-Vis, FTIR, MS-MS and NMR were used to deduce certain aspects of the structure, and the experimental work was combined with computational modeling. The results show polyepicatechin gives a preferable site of reaction via-resorcinol and the lowest polar fraction shows higher antioxidant potency compared to tert-butylhydroquinone (TBHQ). The next step is to assess the enzyme inhibition and anticancer potency of these fractions. Published by Elsevier Ltd. C1 [Racicot, Kenneth; Favreau, Nicole; Fossey, Stephen; Grella, Alexandra R.; Ndou, Tshinanne; Bruno, Ferdinando F.] USA, Natick Soldier Res Dev & Engn Ctr, RDECOM, Natick, MA 01760 USA. RP Bruno, FF (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, RDECOM, Natick, MA 01760 USA. EM Ferdinando_Bruno@uml.edu RI wenjian, wu/G-7517-2011 NR 26 TC 3 Z9 3 U1 1 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0308-8146 J9 FOOD CHEM JI Food Chem. PD FEB 15 PY 2012 VL 130 IS 4 BP 902 EP 907 DI 10.1016/j.foodchem.2011.08.006 PG 6 WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics SC Chemistry; Food Science & Technology; Nutrition & Dietetics GA 836PW UT WOS:000296124600017 ER PT J AU Bacopoulos, P Hagen, SC Cox, AT Dally, WR Bratos, SM AF Bacopoulos, Peter Hagen, Scott C. Cox, Andrew T. Dally, William R. Bratos, Steven M. TI Observation and simulation of winds and hydrodynamics in St. Johns and Nassau Rivers SO JOURNAL OF HYDROLOGY LA English DT Article DE Tides; River flows; Storm event; Sea level anomaly; Manning's roughness ID MODEL; ESTUARIES; EQUATION AB Water surface elevations and daily flows are measured in the St. Johns and Nassau Rivers (north Florida) and reveal a storm event in mid-May 2009 and a sea level anomaly in June and July 2009. In an effort to reproduce these events, wind and tidally driven hydrodynamics are simulated from the deep ocean into the St. Johns and Nassau Rivers using a shallow water equations model. Calibration adjusts spatially distributed Manning's roughness based on modeled-observed discharge. For validation, the model captures the regular tidal fluctuation as well as the hydrodynamic responses of the storm event in mid-May at the six water level gaging stations. At the flow gaging station, the model captures the ebb tendency of the tide as well as a strong perturbation (flood pulse) that occurs because of the storm event in mid-May. (C) 2011 Elsevier B.V. All rights reserved. C1 [Bacopoulos, Peter; Hagen, Scott C.] Univ Cent Florida, Dept Civil Environm & Construct Engn, Orlando, FL 32816 USA. [Cox, Andrew T.] Oceanweather Inc, Cos Cob, CT 06807 USA. [Dally, William R.] Surfbreak Engn Sci Inc, Winter Pk, FL 32792 USA. [Bratos, Steven M.] USA, Corps Engineers, Water Resources Engn Branch, Jacksonville, FL 32232 USA. RP Bacopoulos, P (reprint author), Univ Cent Florida, Dept Civil Environm & Construct Engn, 4000 Cent Florida Blvd,POB 162450, Orlando, FL 32816 USA. EM peter.bacopoulos@ucf.edu FU Taylor Engineering, Inc. [W912EP-06-D-0012]; US Army Corps of Engineers (USACE) FX This research was funded in part under Contract No. W912EP-06-D-0012 from Taylor Engineering, Inc. and the US Army Corps of Engineers (USACE). The statements and conclusions are those of the authors and do not necessarily reflect the views of Taylor Engineering, Inc., USACE, or their affiliates. The authors thank Dingbao Wang, Albert Dai, and Stephen Medeiros for providing reviews of the paper. NR 36 TC 5 Z9 5 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD FEB 14 PY 2012 VL 420 BP 391 EP 402 DI 10.1016/j.jhydrol.2011.12.032 PG 12 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 902ZF UT WOS:000301082000033 ER PT J AU Hu, X Legler, PM Khavrutskii, I Scorpio, A Compton, JR Robertson, KL Friedlander, AM Wallqvist, A AF Hu, Xin Legler, Patricia M. Khavrutskii, Ilja Scorpio, Angelo Compton, Jaimee R. Robertson, Kelly L. Friedlander, Arthur M. Wallqvist, Anders TI Probing the Donor and Acceptor Substrate Specificity of the gamma-Glutamyl Transpeptidase SO BIOCHEMISTRY LA English DT Article ID HELICOBACTER-PYLORI; TRANSFERASE TRANSPEPTIDASE; ESCHERICHIA-COLI; CRYSTAL-STRUCTURE; CATALYTIC MECHANISM; BACILLUS-SUBTILIS; AMINO-ACIDS; EXPRESSION; CAPSULE; IDENTIFICATION AB gamma-Glutamyl transpeptidase (GGT) is a two-substrate enzyme that plays a central role in glutathione metabolism and is a potential target for drug design. GGT catalyzes the cleavage of gamma-glutamyl donor substrates and the transfer of the gamma-glutamyl moiety to an amine of an acceptor substrate or water. Although structures of bacterial GGT have revealed details of the protein-ligand interactions at the donor site, the acceptor substrate site is relatively undefined. The recent identification of a species-specific acceptor site inhibitor, OU749, suggests that these inhibitors may be less toxic than glutamine analogues. Here we investigated the donor and acceptor substrate preferences of Bacillus anthracis GGT (CapD) and applied computational approaches in combination with kinetics to probe the structural basis of the enzyme's substrate and with human GGT. Site-directed mutagenesis studies showed that the R432A and R520S variants exhibited 6- and 95-fold decreases in hydrolase activity, respectively, and that their activity was not stimulated by the addition of the L-Cys acceptor substrate, suggesting an additional role in acceptor binding and/or catalysis of transpeptidation. Rat GGT (and presumably HuGGT) has strict stereospecificity for L-amino acid acceptor substrates, while CapD can utilize both L- and D-acceptor substrates comparably. Modeling and kinetic analysis suggest that R520 and R432 allow two alternate acceptor substrate binding modes for L- and D-acceptors. R432 is conserved in Francisella tularensis, Yersinia pestis, Burkholderia mallei, Helicobacter pylori and Escherichia coli, but not in human GGT. Docking and MD simulations point toward key residues that contribute to inhibitor and acceptor substrate binding, providing a guide to designing novel and specific GGT inhibitors. C1 [Hu, Xin; Khavrutskii, Ilja; Wallqvist, Anders] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. [Legler, Patricia M.; Compton, Jaimee R.; Robertson, Kelly L.] USN, Res Labs, Washington, DC 20375 USA. [Scorpio, Angelo; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Hu, X (reprint author), USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. EM xin.hu@nih.gov; patricia.legler@nrl.navy.mil FU Defense Threat and Reduction Agency [2.10010.08.RD.B, CBM.THERB.02.11.RD.012]; U.S. Department of Defense under the High Performance Computing Software Applications Institutes initiative FX This work was sponsored by Defense Threat and Reduction Agency Grants 2.10010.08.RD.B and CBM.THERB.02.11.RD.012 and the U.S. Department of Defense High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes initiative. NR 52 TC 20 Z9 20 U1 0 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD FEB 14 PY 2012 VL 51 IS 6 BP 1199 EP 1212 DI 10.1021/bi200987b PG 14 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 890GK UT WOS:000300132900015 PM 22257032 ER PT J AU Convertino, M AF Convertino, M. TI Neutral metacommunity clustering and SAR: River basin vs. 2-D landscape biodiversity patterns (vol 222, pg 1863, 2011) SO ECOLOGICAL MODELLING LA English DT Correction C1 [Convertino, M.] IFAS, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. [Convertino, M.] USACE Engn Res & Dev Ctr ERDC, Risk Modeling & Decis Sci Area, Concord, MA USA. RP Convertino, M (reprint author), IFAS, Dept Agr & Biol Engn, Frazier Rogers Hall,Museum Rd,POB 110570, Gainesville, FL 32611 USA. EM mconvertino@ufl.edu NR 1 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD FEB 10 PY 2012 VL 226 BP 139 EP 139 DI 10.1016/j.ecolmodel.2011.11.024 PG 1 WC Ecology SC Environmental Sciences & Ecology GA 912PU UT WOS:000301812900011 ER PT J AU Mantey, K Zhu, AP Boparai, J Nayfeh, M Marsh, C Al Chaar, G AF Mantey, Kevin Zhu, Aiping Boparai, Jack Nayfeh, Munir Marsh, Charles Al Chaar, Ghassan TI Observation of linear solid-solid phase transformation in silicon nanoparticles SO PHYSICAL REVIEW B LA English DT Article ID HIGH-PRESSURE; SI NANOPARTICLES; SURFACE-STATES; NANOCRYSTALS; FILMS AB In bulk single-crystal silicon, the semiconducting diamond-to-metallic beta-Sn phase transformation nucleates on defects, and is manifested by a sharp uptake in light absorption at a threshold of similar to 11 Gpa, accompanied with the creation of nanosized (20-50 nm) fragmentation domains. We report on the observation of linear uptakes in the absorption and in the luminescence and with insignificant spectral change in ultrasmall 1-nm Si particles. We associate the gradual absorption uptake and luminescence yield with silicon-metal transformation on the surface. The insignificant change in the spectral content of the luminescence points to surface stability for particles, which are smaller than the bulk fragmentation domain. First-principles atomistic calculations yield absorption behavior that exhibits gradual uptake followed by sharp uptake at similar to 9-11 Gpa. The results point to the conclusion that two-dimensional surface-like phase transformations are manifested by linear uptake in absorption and luminescence. C1 [Mantey, Kevin; Zhu, Aiping; Boparai, Jack; Nayfeh, Munir] Univ Illinois, Dept Phys, Urbana, IL 61801 USA. [Marsh, Charles; Al Chaar, Ghassan] CERL ERDC, Champaign, IL 61820 USA. RP Mantey, K (reprint author), Univ Illinois, Dept Phys, Urbana, IL 61801 USA. EM m-nayfeh@illinois.edu OI Nayfeh, Munir Hasan/0000-0002-1459-4976 FU NSF [ATM 08-02-499] FX The authors acknowledge the US Army and the University of Illinois. We also acknowledge NSF Grant ATM 08-02-499. This paper is in memory of our collaborator on this study, the late Harry Drickamer, Professor of Chemical Engineering at the University of Illinois at Urbana-Champaign, who passed away before the work could have been completed. He was a pioneer in the field of pressure tuning studies, which led to advances in the study of molecular, atomic, and electronic properties of matter. NR 27 TC 0 Z9 0 U1 2 U2 17 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD FEB 10 PY 2012 VL 85 IS 8 AR 085417 DI 10.1103/PhysRevB.85.085417 PG 5 WC Physics, Condensed Matter SC Physics GA 889RP UT WOS:000300091200005 ER PT J AU Douglas, TA Domine, F Barret, M Anastasio, C Beine, HJ Bottenheim, J Grannas, A Houdier, S Netcheva, S Rowland, G Staebler, R Steffen, A AF Douglas, Thomas A. Domine, Florent Barret, Manuel Anastasio, Cort Beine, Harry J. Bottenheim, Jan Grannas, Amanda Houdier, Stephan Netcheva, Stoyka Rowland, Glenn Staebler, Ralf Steffen, Alexandra TI Frost flowers growing in the Arctic ocean-atmosphere-sea ice-snow interface: 1. Chemical composition SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ENVIRONMENTAL WATER SAMPLES; OZONE DEPLETION EVENTS; CARBONYL-COMPOUNDS; POLAR SUNRISE; AQUEOUS PHOTOOXIDATION; ORGANIC-COMPOUNDS; FRESH-WATER; SURFACE; MERCURY; GLYOXAL AB Frost flowers, intricate featherlike crystals that grow on refreezing sea ice leads, have been implicated in lower atmospheric chemical reactions. Few studies have presented chemical composition information for frost flowers over time and many of the chemical species commonly associated with Polar tropospheric reactions have never been reported for frost flowers. We undertook this study on the sea ice north of Barrow, Alaska to quantify the major ion, stable oxygen and hydrogen isotope, alkalinity, light absorbance by soluble species, organochlorine, and aldehyde composition of seawater, brine, and frost flowers. For many of these chemical species we present the first measurements from brine or frost flowers. Results show that major ion and alkalinity concentrations, stable isotope values, and major chromophore (NO3- and H2O2) concentrations are controlled by fractionation from seawater and brine. The presence of these chemical species in present and future sea ice scenarios is somewhat predictable. However, aldehydes, organochlorine compounds, light absorbing species, and mercury (part 2 of this research and Sherman et al. (2012)) are deposited to frost flowers through less predictable processes that probably involve the atmosphere as a source. The present and future concentrations of these constituents in frost flowers may not be easily incorporated into future sea ice or lower atmospheric chemistry scenarios. Thinning of Arctic sea ice will likely present more open sea ice leads where young ice, brine, and frost flowers form. How these changing ice conditions will affect the interactions between ice, brine, frost flowers and the lower atmosphere is unknown. C1 [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Domine, Florent; Barret, Manuel; Houdier, Stephan] Univ Grenoble 1, Lab Glaciol & Geophys Environm, CNRS, INSU, F-38402 St Martin Dheres, France. [Bottenheim, Jan; Netcheva, Stoyka; Staebler, Ralf; Steffen, Alexandra] Environm Canada, Air Qual Res Div, Toronto, ON M3H 5T4, Canada. [Grannas, Amanda; Rowland, Glenn] Villanova Univ, Dept Chem, Villanova, PA 19085 USA. [Anastasio, Cort; Beine, Harry J.] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. RP Douglas, TA (reprint author), USA, Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA. EM thomas.a.douglas@usace.army.mil; florent@lgge.obs.ujf-grenoble.fr; barret@lgge.obs.ujf-grenoble.fr; canastasio@ucdavis.edu; hbeine@ucdavis.edu; jwbottenheim@gmail.com; amanda.grannas@villanova.edu; stephan@lgge.obs.ujf-grenoble.fr; stoyka.netcheva@ec.gc.ca; glenn.rowland@villanova.edu; ralf.staebler@ec.gc.ca; alexandra.steffen@ec.gc.ca FU U.S. National Science Foundation [ATM-0547435]; National Aeronautic and Space Administration; U.S. Army Cold Regions Research and Engineering Laboratory; French Polar Institute [IPEV 1017]; U.S. National Science Foundation Atmospheric Sciences [ATM-0807702] FX This work is part of the international multidisciplinary Ocean-atmosphere-Sea Ice-Snowpack (OASIS) program. The numerous collaborators, science teams, and researchers from the OASIS campaign are gratefully acknowledged. Douglas' research was supported by the U.S. National Science Foundation, the National Aeronautic and Space Administration, and the U.S. Army Cold Regions Research and Engineering Laboratory. F. Domine, M. Barret, and S. Houdier were supported by the French Polar Institute through grant IPEV 1017. They acknowledge Bruno Dellile, Nicolas-Xavier Geilfus and Gauthier Carnat from University of Liege for making it possible to collect ice core samples and Hans-Werner Jacobi for planning some of the sea ice sampling trips. H. Beine and C. Anastasio acknowledge the U.S. National Science Foundation Atmospheric Sciences ATM-0807702 and Tad Doane (UC Davis, LAWR) for the nitrate/nitrite analyses. A. Grannas acknowledges the U.S. National Science Foundation Grant ATM-0547435. Spencer Brown granted use of his photos from the March 20 sampling event. Don Perovich and Matthew Sturm provided insight into sea ice and snow in the Barrow area. Paul Shepson is acknowledged for providing insight throughout the field campaign. Son Nghiem provided information on the MODIS imagery. Snow-NET data were provided by Matthew Sturm and colleagues. Discussions with Rolf Sander helped clarify our interpretation of the alkalinity measurements and results. The Barrow Arctic Science Consortium and Polar Field Services provided logistical support. NR 82 TC 25 Z9 26 U1 7 U2 46 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD FEB 9 PY 2012 VL 117 AR D00R09 DI 10.1029/2011JD016460 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 891QJ UT WOS:000300231400003 ER PT J AU Sherman, LS Blum, JD Douglas, TA Steffen, A AF Sherman, Laura S. Blum, Joel D. Douglas, Thomas A. Steffen, Alexandra TI Frost flowers growing in the Arctic ocean-atmosphere-sea ice-snow interface: 2. Mercury exchange between the atmosphere, snow, and frost flowers SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID MASS-INDEPENDENT FRACTIONATION; STABLE-ISOTOPE FRACTIONATION; DEPLETION EVENTS; POLAR SUNRISE; OZONE DEPLETION; GASEOUS MERCURY; TROPOSPHERIC CHEMISTRY; CHEMICAL-REACTIONS; MAGNETIC ISOTOPE; NUCLEAR-SPIN AB Frost flowers are ice crystals that grow on refreezing sea ice leads in Polar Regions by wicking brine from the sea ice surface and accumulating vapor phase condensate. These crystals contain high concentrations of mercury (Hg) and are believed to be a source of reactive halogens, but their role in Hg cycling and impact on the fate of Hg deposited during atmospheric mercury depletion events (AMDEs) are not well understood. We collected frost flowers growing on refreezing sea ice near Barrow, Alaska (U.S.A.) during an AMDE in March 2009 and measured Hg concentrations and Hg stable isotope ratios in these samples to determine the origin of Hg associated with the crystals. We observed decreasing Delta Hg-199 values in the crystals as they grew from new wet frost flowers (mean Delta Hg-199 = 0.77 +/- 0.13 parts per thousand, 1 s.d.) to older dry frost flowers (mean Delta Hg-199 = 0.10 +/- 0.05 parts per thousand, 1 s.d.). Over the same time period, mean Hg concentrations in these samples increased from 131 +/- 6 ng/L (1 s.d.) to 180 +/- 28 ng/L (1 s.d.). Coupled with a previous study of Hg isotopic fractionation during AMDEs, these results suggest that Hg initially deposited to the local snowpack was subsequently reemitted during photochemical reduction reactions and ultimately accumulated on the frost flowers. As a result of this process, frost flowers may lead to enhanced local retention of Hg deposited during AMDEs and may increase Hg loading to the Arctic Ocean. C1 [Sherman, Laura S.; Blum, Joel D.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA. [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Steffen, Alexandra] Environm Canada, Air Qual Res Div, Toronto, ON M3H 5T4, Canada. RP Sherman, LS (reprint author), Univ Michigan, Dept Earth & Environm Sci, 1100 N Univ Ave, Ann Arbor, MI 48109 USA. EM lsaylors@umich.edu FU DOD-ONR; University of Michigan Graham Environmental Sustainability Institute; University of Michigan; U.S. National Science Foundation; National Aeronautic and Space Administration; Environment Canada; Canadian IPY program FX Funding for L. S. Sherman was provided by a National Defense Science and Engineering Graduate Fellowship (DOD-ONR) and the University of Michigan Graham Environmental Sustainability Institute. Funding for J. D. Blum and laboratory support was provided by the John D. MacArthur Professorship at the University of Michigan. Funding for sample collection and research conducted by T. A. Douglas was supported by the U.S. National Science Foundation and the National Aeronautic and Space Administration. Field logistics in Barrow, AK, were provided by the Barrow Arctic Science Consortium and were partially funded by Environment Canada and the Canadian IPY program. We thank two anonymous reviewers for comments that greatly improved this manuscript. NR 58 TC 17 Z9 18 U1 5 U2 30 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD FEB 9 PY 2012 VL 117 AR D00R10 DI 10.1029/2011JD016186 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 891QJ UT WOS:000300231400001 ER PT J AU Peric, M Fajdetic, A Rupcic, R Alihodzic, S Ziher, D Krajacic, MB Smith, KS Ivezic-Schonfeld, Z Padovan, J Landek, G Jelic, D Hutinec, A Mesic, M Ager, A Ellis, WY Milhous, WK Ohrt, C Spaventi, R AF Peric, Mihaela Fajdetic, Andrea Rupcic, Renata Alihodzic, Sulejman Ziher, Dinko Krajacic, Mirjana Bukvic Smith, Kirsten S. Ivezic-Schoenfeld, Zrinka Padovan, Jasna Landek, Goran Jelic, Dubravko Hutinec, Antun Mesic, Milan Ager, Arba Ellis, William Y. Milhous, Wilbur K. Ohrt, Colin Spaventi, Radan TI Antimalarial Activity of 9a-N Substituted 15-Membered Azalides with Improved in Vitro and in Vivo Activity over Azithromycin SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; COMBINATION THERAPY; CONTROLLED-TRIAL; CLINICAL-TRIAL; DOUBLE-BLIND; PROPHYLAXIS; CHLOROQUINE; RESISTANCE; INVITRO; ANTIBIOTICS AB Novel classes of antimalarial drugs are needed due to emerging drug resistance. Azithromycin, the first macrolide investigated for malaria treatment and prophylaxis, failed as a single agent and thus novel analogues were envisaged as the next generation with improved activity. We synthesized 42 new 9a-N substituted 15-membered azalides with amide and amine functionalities via simple and inexpensive chemical procedures using easily available building blocks. These compounds exhibited marked advances over azithromycin in vitro in terms of potency against Plasmodium falciparum (over 100-fold) and high selectivity for the parasite and were characterized by moderate oral bioavailability in vivo. Two amines and one amide derivative showed improved in vivo potency in comparison to azithromycin when tested in a mouse efficacy model. Results obtained for compound 6u, including improved in vitro potency, good pharmacokinetic parameters, and in vivo efficacy higher than azithromycin and comparable to chloroquine, warrant its further development for malaria treatment and prophylaxis. C1 [Peric, Mihaela; Fajdetic, Andrea; Rupcic, Renata; Alihodzic, Sulejman; Ziher, Dinko; Krajacic, Mirjana Bukvic; Ivezic-Schoenfeld, Zrinka; Padovan, Jasna; Landek, Goran; Jelic, Dubravko; Hutinec, Antun; Mesic, Milan; Spaventi, Radan] GlaxoSmithKline Res Ctr Zagreb Ltd, Zagreb 10000, Croatia. [Smith, Kirsten S.; Ellis, William Y.; Milhous, Wilbur K.; Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC USA. [Ager, Arba] Univ Miami, Dept Microbiol & Immunol, Miami, FL 33177 USA. [Smith, Kirsten S.] USA, Med Mat Dev Act, Ft Detrick, MD 21702 USA. RP Peric, M (reprint author), Univ Zagreb, Sch Med, Ctr Translat & Clin Res, Salata 2, Zagreb 10000, Croatia. EM mihaela.peric@mef.hr FU Military Infectious Diseases Research Program; US Army Medical Research and Materiel Command FX The authors thank Dr. Lucia Gerena for the hard work with the in vitro susceptibility testing of P. falciparum strains. This study was supported by the Military Infectious Diseases Research Program and US Army Medical Research and Materiel Command. The U.S. government authors declare no competing financial interests. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting the views of the Department of the Army, the Department of Defense, or the United States government. NR 43 TC 16 Z9 17 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD FEB 9 PY 2012 VL 55 IS 3 BP 1389 EP 1401 DI 10.1021/jm201615t PG 13 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 888DV UT WOS:000299984900034 PM 22148880 ER PT J AU Singh, N Sun, HM Chaudhury, S AbdulHameed, MDM Wallqvist, A Tawa, G AF Singh, Narender Sun, Hongmao Chaudhury, Sidhartha AbdulHameed, Mohamed Diwan M. Wallqvist, Anders Tawa, Gregory TI A physicochemical descriptor-based scoring scheme for effective and rapid filtering of kinase-like chemical space SO JOURNAL OF CHEMINFORMATICS LA English DT Article ID DRUG-LIKE PROPERTIES; COMBINATORIAL LIBRARY DESIGN; MOLECULAR-PROPERTIES; TARGETED LIBRARY; SELECTION CRITERIA; PROTEIN-KINASES; IN-VITRO; DISCOVERY; PREDICTION; INHIBITORS AB Background: The current chemical space of known small molecules is estimated to exceed 10(60) structures. Though the largest physical compound repositories contain only a few tens of millions of unique compounds, virtual screening of databases of this size is still difficult. In recent years, the application of physicochemical descriptor-based profiling, such as Lipinski's rule-of-five for drug-likeness and Oprea's criteria of lead-likeness, as early stage filters in drug discovery has gained widespread acceptance. In the current study, we outline a kinase-likeness scoring function based on known kinase inhibitors. Results: The method employs a collection of 22,615 known kinase inhibitors from the ChEMBL database. A kinase-likeness score is computed using statistical analysis of nine key physicochemical descriptors for these inhibitors. Based on this score, the kinase-likeness of four publicly and commercially available databases, i.e., National Cancer Institute database (NCI), the Natural Products database (NPD), the National Institute of Health's Molecular Libraries Small Molecule Repository (MLSMR), and the World Drug Index (WDI) database, is analyzed. Three of these databases, i.e., NCI, NPD, and MLSMR are frequently used in the virtual screening of kinase inhibitors, while the fourth WDI database is for comparison since it covers a wide range of known chemical space. Based on the kinase-likeness score, a kinase-focused library is also developed and tested against three different kinase targets selected from three different branches of the human kinome tree. Conclusions: Our proposed methodology is one of the first that explores how the narrow chemical space of kinase inhibitors and its relevant physicochemical information can be utilized to build kinase-focused libraries and prioritize pre-existing compound databases for screening. We have shown that focused libraries generated by filtering compounds using the kinase-likeness score have, on average, better docking scores than an equivalent number of randomly selected compounds. Beyond library design, our findings also impact the broader efforts to identify kinase inhibitors by screening pre-existing compound libraries. Currently, the NCI library is the most commonly used database for screening kinase inhibitors. Our research suggests that other libraries, such as MLSMR, are more kinase-like and should be given priority in kinase screenings. C1 [Singh, Narender; Chaudhury, Sidhartha; AbdulHameed, Mohamed Diwan M.; Wallqvist, Anders; Tawa, Gregory] USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Sun, Hongmao] NIH Chem Genom Ctr, Rockville, MD 20850 USA. RP Tawa, G (reprint author), USA, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM gtawa@bioanalysis.org RI AbdulHameed, Mohamed Diwan M/O-3088-2015; OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T] FX Funding of this research was provided by the U.S. Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. NR 66 TC 3 Z9 3 U1 1 U2 27 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1758-2946 J9 J CHEMINFORMATICS JI J. Cheminformatics PD FEB 8 PY 2012 VL 4 AR 4 DI 10.1186/1758-2946-4-4 PG 12 WC Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA 917EE UT WOS:000302154500001 PM 22316383 ER PT J AU Sparrevik, M Barton, DN Bates, ME Linkov, I AF Sparrevik, Magnus Barton, David N. Bates, Mathew E. Linkov, Igor TI Use of Stochastic Multi-Criteria Decision Analysis to Support Sustainable Management of Contaminated Sediments SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LIFE-CYCLE ASSESSMENT; REMEDIATION; ASSESSMENTS; NORWAY; HEALTH AB Sustainable management of contaminated sediments requires careful prioritization of available resources and focuses on efforts to optimize decisions that consider environmental, economic, and societal aspects simultaneously. This may be achieved by combining different analytical approaches such as risk analysis (RA), life cycle analysis (LCA), multicriteria decision analysis (MCDA), and economic valuation methods. We propose the use of stochastic MCDA based on outranking algorithms to implement integrative sustainability strategies for sediment management. In this paper we use the method to select the best sediment management alternatives for the dibenzo-p-dioxin and -furan (PCDD/F) contaminated Grenland fjord in Norway. In the analysis, the benefits of health risk reductions and socio-economic benefits from removing seafood health advisories are evaluated against the detriments of remedial costs and life cycle environmental impacts. A value-plural based weighing of criteria is compared to criteria weights mimicking traditional cost-effectiveness (CEA) and cost-benefit (CBA) analyses. Capping highly contaminated areas in the inner or outer fjord is identified as the most preferable remediation alternative under all criteria schemes and the results are confirmed by a probabilistic sensitivity analysis. The proposed methodology can serve as a flexible framework for future decision support and can be a step toward more sustainable decision making for contaminated sediment management. It may be applicable to the broader field of ecosystem restoration for trade-off analysis between ecosystem services and restoration costs. C1 [Sparrevik, Magnus] Norwegian Geotech Inst, NO-0806 Oslo, Norway. [Sparrevik, Magnus] Norwegian Univ Technol, Dept Ind Econ & Technol Management, N-7491 Trondheim, Norway. [Barton, David N.] Norwegian Inst Nat Res, NO-0349 Oslo, Norway. [Bates, Mathew E.; Linkov, Igor] USA, Environm Lab, Engineer Res & Dev Ctr, Corps Engineers, Concord, MA 01742 USA. RP Sparrevik, M (reprint author), Norwegian Geotech Inst, POB 3930 Ulleval Stad, NO-0806 Oslo, Norway. EM magnus.sparrevik@ngi.no FU Norwegian Research Council; U.S. Army Corps of Engineers; SEDFLEX; Opticap project FX We thank previous studies for the work performed on the Grenland fjord and especially the Opticap project (www.opticap.no), the SEDFLEX project, and the Norwegian Research Council for financing the studies. A special gratitude to Bjorn Vidar Vangelsten of NGI for adapting the Stochastic MCDA to use of skewed normal distributions. M.E.B. and I.L. acknowledge funding from the Dredging Operation Environmental Research (DOER) program of the U.S. Army Corps of Engineers. Permission was granted by the USACE Chief of Engineers to publish this material. NR 40 TC 14 Z9 15 U1 9 U2 59 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD FEB 7 PY 2012 VL 46 IS 3 BP 1326 EP 1334 DI 10.1021/es202225x PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 886OT UT WOS:000299864400009 PM 22191941 ER PT J AU Moon, JJ Suh, H Polhemus, ME Ockenhouse, CF Yadava, A Irvine, DJ AF Moon, James J. Suh, Heikyung Polhemus, Mark E. Ockenhouse, Christian F. Yadava, Anjali Irvine, Darrell J. TI Antigen-Displaying Lipid-Enveloped PLGA Nanoparticles as Delivery Agents for a Plasmodium vivax Malaria Vaccine SO PLOS ONE LA English DT Article ID IMMUNE-RESPONSES; ANTIBODY-RESPONSES; EPITOPE DENSITY; IMMUNOGENICITY; MICROPARTICLES; INFLAMMASOME; IMMUNIZATION; SPOROZOITES AB The parasite Plasmodium vivax is the most frequent cause of malaria outside of sub-Saharan Africa, but efforts to develop viable vaccines against P. vivax so far have been inadequate. We recently developed pathogen-mimicking polymeric vaccine nanoparticles composed of the FDA-approved biodegradable polymer poly(lactide-co-glycolide) acid (PLGA) "enveloped'' by a lipid membrane. In this study, we sought to determine whether this vaccine delivery platform could be applied to enhance the immune response against P. vivax sporozoites. A candidate malaria antigen, VMP001, was conjugated to the lipid membrane of the particles, and an immunostimulatory molecule, monophosphoryl lipid A (MPLA), was incorporated into the lipid membranes, creating pathogen-mimicking nanoparticle vaccines (VMP001-NPs). Vaccination with VMP001-NPs promoted germinal center formation and elicited durable antigen-specific antibodies with significantly higher titers and more balanced Th1/Th2 responses in vivo, compared with vaccines composed of soluble protein mixed with MPLA. Antibodies raised by NP vaccinations also exhibited enhanced avidity and affinity toward the domains within the circumsporozoite protein implicated in protection and were able to agglutinate live P. vivax sporozoites. These results demonstrate that these VMP001-NPs are promising vaccines candidates that may elicit protective immunity against P. vivax sporozoites. C1 [Moon, James J.; Suh, Heikyung; Irvine, Darrell J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Moon, James J.; Suh, Heikyung; Irvine, Darrell J.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Polhemus, Mark E.; Ockenhouse, Christian F.; Yadava, Anjali] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Irvine, Darrell J.] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Irvine, Darrell J.] Ragon Inst MGH MIT & Harvard, Boston, MA USA. [Suh, Heikyung; Irvine, Darrell J.] Howard Hughes Med Inst, Chevy Chase, MD USA. RP Moon, JJ (reprint author), MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. EM djirvine@mit.edu FU Ragon Institute of MGH, MIT, and Harvard; Department of Defense [W911NF-07-D-0004] FX This work was supported in part by the Ragon Institute of MGH, MIT, and Harvard, and the Department of Defense (contract W911NF-07-D-0004). DJI is an investigator of the Howard Hughes Medical Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 35 TC 48 Z9 48 U1 2 U2 33 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 6 PY 2012 VL 7 IS 2 AR e31472 DI 10.1371/journal.pone.0031472 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 917LV UT WOS:000302179300021 PM 22328935 ER PT J AU Meyers, RE Deacon, KS Tunick, AD Shih, Y AF Meyers, Ronald E. Deacon, Keith S. Tunick, Arnold D. Shih, Yanhua TI Virtual ghost imaging through turbulence and obscurants using Bessel beam illumination SO APPLIED PHYSICS LETTERS LA English DT Article DE image processing; laser beams; light diffraction ID DIFFRACTION; LIGHT AB We experimentally demonstrate a single sensor virtual ghost imaging (VGI) configuration that uses the physics of nearly diffraction free light sources to penetrate partially obscuring media or turbulent media and generate images of remote opaque objects. Randomly displaced nearly diffraction free Bessel beams provided improved illumination patterns for VGI and resolving small distant targets. VGI recovered the image of objects even when the coarse illuminating Bessel beam was transmitted through obscuring and turbulent media or through a small transversely displaced aperture. Bessel beam experiments are compared with Gaussian beam experiments under similar conditions. (C) 2012 American Institute of Physics. [doi: 10.1063/1.3684613] C1 [Meyers, Ronald E.; Deacon, Keith S.; Tunick, Arnold D.] USA, Res Lab, Adelphi, MD 20783 USA. [Shih, Yanhua] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. RP Meyers, RE (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM ronald.e.meyers6.civ@mail.mil FU US Army Research Laboratory (ARL); ARL [W911NF-11-2-0074] FX R. Meyers, K. Deacon and A. Tunick thank the US Army Research Laboratory (ARL) for support. Y. H. Shih thanks ARL, W911NF-11-2-0074, for support. NR 16 TC 23 Z9 23 U1 0 U2 18 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 6 PY 2012 VL 100 IS 6 AR 061126 DI 10.1063/1.3684613 PG 4 WC Physics, Applied SC Physics GA 891JW UT WOS:000300214000026 ER PT J AU Rawat, A Elasri, MO Gust, KA George, G Pham, D Scanlan, LD Vulpe, C Perkins, EJ AF Rawat, Arun Elasri, Mohamed O. Gust, Kurt A. George, Glover Don Pham Scanlan, Leona D. Vulpe, Chris Perkins, Edward J. TI CAPRG: Sequence Assembling Pipeline for Next Generation Sequencing of Non-Model Organisms SO PLOS ONE LA English DT Article ID BURROWS-WHEELER TRANSFORM; SHORT READ ALIGNMENT; NORTHERN BOBWHITE; GENOME; PROGRAM; TOOL; ALGORITHMS; ULTRAFAST; SYSTEM; ESTS AB Our goal is to introduce and describe the utility of a new pipeline "Contigs Assembly Pipeline using Reference Genome'' (CAPRG), which has been developed to assemble "long sequence reads'' for non-model organisms by leveraging a reference genome of a closely related phylogenetic relative. To facilitate this effort, we utilized two avian transcriptomic datasets generated using ROCHE/454 technology as test cases for CAPRG assembly. We compared the results of CAPRG assembly using a reference genome with the results of existing methods that utilize de novo strategies such as VELVET, PAVE, and MIRA by employing parameter space comparisons (intra-assembling comparison). CAPRG performed as well or better than the existing assembly methods based on various benchmarks for "gene-hunting.'' Further, CAPRG completed the assemblies in a fraction of the time required by the existing assembly algorithms. Additional advantages of CAPRG included reduced contig inflation resulting in lower computational resources for annotation, and functional identification for contigs that may be categorized as "unknowns'' by de novo methods. In addition to providing evaluation of CAPRG performance, we observed that the different assembly (inter-assembly) results could be integrated to enhance the putative gene coverage for any transcriptomics study. C1 [Rawat, Arun] Translat Genom Res Inst N, Ctr Pathogen Informat, Flagstaff, AZ USA. [Rawat, Arun; Elasri, Mohamed O.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Gust, Kurt A.; Perkins, Edward J.] USA, Environm Lab, EP P, Engn Res & Dev Ctr, Vicksburg, MS USA. [George, Glover] Univ So Mississippi, Sch Comp Sci, Hattiesburg, MS 39406 USA. [Don Pham; Scanlan, Leona D.; Vulpe, Chris] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA. RP Rawat, A (reprint author), Translat Genom Res Inst N, Ctr Pathogen Informat, Flagstaff, AZ USA. EM arun.rawat@eagles.usm.edu; edward.j.perkins@usace.army.mil OI Rawat, Arun/0000-0003-0540-2044 FU U.S. Army Environmental Quality/Installations Research [W912HZ-08-C-0032]; Mississippi INBRE [P20RR016476]; National Center for Research Resources; National Institutes of Health FX The work was funded by grant #W912HZ-08-C-0032 from the U.S. Army Environmental Quality/Installations Research Program and Mississippi INBRE (P20RR016476) funded by the National Center for Research Resources, National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 31 TC 4 Z9 4 U1 0 U2 11 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD FEB 3 PY 2012 VL 7 IS 2 AR e30370 DI 10.1371/journal.pone.0030370 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 917LO UT WOS:000302178400007 PM 22319566 ER PT J AU Sanborn, B Nie, X Chen, W Weerasooriya, T AF Sanborn, B. Nie, X. Chen, W. Weerasooriya, T. TI Inertia effects on characterization of dynamic response of brain tissue SO JOURNAL OF BIOMECHANICS LA English DT Article DE Brain tissue; Shear response; Radial inertia; Mechanical behavior; Dynamic response ID HOPKINSON PRESSURE BAR; MECHANICAL-BEHAVIOR AB Modeling and simulation of traumatic brain injury (TB!) resulted from collision or blast loading requires characterization of mechanical response over a wide range of loading rates under valid testing conditions. In this study, mechanical response of fresh bovine brain tissue was studied using the two modified Kolsky bar techniques. Radial deformation behavior of annular specimens, which are typically used to characterize the dynamic uniaxial compressive response of biological tissues, was examined using a modified Kolsky bar and a high speed camera to collect images while the specimen deforms at an axial strain rate of 2000 s(-1). The high-speed images revealed inhomogeneous specimen deformation possibly brought about by radial inertia and causing a multi-axial stress state. To acquire valid stress-strain results that can be used to produce constitutive behavior of the soft materials, a novel torsion technique was developed to obtain pure shear response at dynamic loading rates. Experimental results show clear differences in the material response using the two methods. These results indicate that the previously demonstrated annular specimen geometry aimed at reducing inertia induced stress components for high rate soft materials uniaxial-compressive testing may still possess a significant component of radial inertia induced radial stress which consequently caused the observed inhomogeneous deformation in brain tissue test samples. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Nie, X.; Chen, W.] Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA. [Sanborn, B.; Weerasooriya, T.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Nie, X.; Chen, W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. RP Chen, W (reprint author), Purdue Univ, Sch Aeronaut Astronaut, 701 W Stadium Ave, W Lafayette, IN 47907 USA. EM wchen@purdue.edu FU US Army Research Laboratory; Purdue University FX This research is supported by a collaborative program between US Army Research Laboratory and Purdue University. NR 23 TC 6 Z9 7 U1 2 U2 15 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 EI 1873-2380 J9 J BIOMECH JI J. Biomech. PD FEB 2 PY 2012 VL 45 IS 3 BP 434 EP 439 DI 10.1016/j.jbiomech.2011.12.017 PG 6 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 900CG UT WOS:000300863600004 PM 22226509 ER PT J AU Sinitski, EH Hansen, AH Wilken, JM AF Sinitski, Emily H. Hansen, Andrew H. Wilken, Jason M. TI Biomechanics of the ankle-foot system during stair ambulation: Implications for design of advanced ankle-foot prostheses SO JOURNAL OF BIOMECHANICS LA English DT Article DE Ankle; Foot; Level; Stairs; Prosthesis ID ROLLOVER CHARACTERISTICS; COORDINATE SYSTEM; JOINT STIFFNESS; WALKING; GAIT; SHAPES AB Unilateral lower limb prosthesis users display temporal, kinematic, and kinetic asymmetries between limbs while ascending and descending stairs. These asymmetries are due, in part, to the inability of current prosthetic devices to effectively mimic normal ankle function. The purpose of this study was to provide a comprehensive set of biomechanical data for able-bodied and unilateral transtibial amputee (TTA) ankle-foot systems for level-ground (LG), stair ascent (SA), and stair descent (SD), and to characterize deviations from normal performance associated with prosthesis use. Ankle joint kinematics, kinetics, torque-angle curves, and effective shapes were calculated for twelve able-bodied individuals and twelve individuals with TTA. The data from this study demonstrated the prosthetic limb can more effectively mimic the range of motion and power output of a normal ankle-foot during LG compared to SA and SD. There were larger differences between the prosthetic and able-bodied limbs during SA and SD, most evident in the torque-angle curves and effective shapes. These data can be used by persons designing ankle-foot prostheses and provide comparative data for assessment of future ankle-foot prosthesis designs. Published by Elsevier Ltd. C1 [Sinitski, Emily H.; Wilken, Jason M.] Brooke Army Med Ctr, Mil Performance Lab, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. [Hansen, Andrew H.] Minneapolis VA Hlth Care Syst, Minneapolis, MN USA. [Hansen, Andrew H.] Northwestern Univ, Dept Phys Med & Rehabil, Feinberg Sch Med, Evanston, IL 60208 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Mil Performance Lab, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. EM jason.Wilken@us.army.mil OI Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program; Telemedicine and Advanced Technology Research Center; Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service FX This study was funded in part by grants from the Military Amputee Research Program (to JMW) and the Telemedicine and Advanced Technology Research Center (to JMW) and was supported by the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research and Development Service (AHH). The authors would like to thank Jennifer Aldridge, Kelly Rodriguez, and Linda Waetjen for their contributions to data collection and processing. NR 25 TC 17 Z9 17 U1 2 U2 17 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD FEB 2 PY 2012 VL 45 IS 3 BP 588 EP 594 DI 10.1016/j.jbiomech.2011.11.007 PG 7 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 900CG UT WOS:000300863600026 PM 22177669 ER PT J AU Barouch, DH Liu, JY Li, HL Maxfield, LF Abbink, P Lynch, DM Iampietro, MJ SanMiguel, A Seaman, MS Ferrari, G Forthal, DN Ourmanov, I Hirsch, VM Carville, A Mansfield, KG Stablein, D Pau, MG Schuitemaker, H Sadoff, JC Billings, EA Rao, M Robb, ML Kim, JH Marovich, MA Goudsmit, J Michael, NL AF Barouch, Dan H. Liu, Jinyan Li, Hualin Maxfield, Lori F. Abbink, Peter Lynch, Diana M. Iampietro, M. Justin SanMiguel, Adam Seaman, Michael S. Ferrari, Guido Forthal, Donald N. Ourmanov, Ilnour Hirsch, Vanessa M. Carville, Angela Mansfield, Keith G. Stablein, Donald Pau, Maria G. Schuitemaker, Hanneke Sadoff, Jerald C. Billings, Erik A. Rao, Mangala Robb, Merlin L. Kim, Jerome H. Marovich, Mary A. Goudsmit, Jaap Michael, Nelson L. TI Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys SO NATURE LA English DT Article ID CELLULAR IMMUNE-RESPONSES; LOW-DOSE CHALLENGE; IMMUNODEFICIENCY VIRUS SIVMAC239; PATHOGENIC SIV; INFECTION; HIV-1; REPLICATION; ANTIBODIES; MACAQUES; VECTORS AB Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection against acquisition of infection has previously only been reported against neutralization-sensitive virus challenges(1-3). Here we demonstrate vaccine protection against acquisition of fully heterologous, neutralization-resistant simian immunodeficiency virus (SIV) challenges in rhesus monkeys. Adenovirus/poxvirus and adenovirus/adenovirus-vector-based vaccines expressing SIV(SME543) Gag, Pol and Env antigens resulted in an 80% or greater reduction in the per-exposure probability of infection(4,5) against repetitive, intrarectal SIV(MAC251) challenges in rhesus monkeys. Protection against acquisition of infection showed distinct immunological correlates compared with post-infection virological control and required the inclusion of Env in the vaccine regimen. These data demonstrate the proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys. C1 [Barouch, Dan H.; Liu, Jinyan; Li, Hualin; Maxfield, Lori F.; Abbink, Peter; Lynch, Diana M.; Iampietro, M. Justin; SanMiguel, Adam; Seaman, Michael S.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA. [Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Boston, MA 02114 USA. [Ferrari, Guido] Duke Univ, Med Ctr, Durham, NC 27710 USA. [Forthal, Donald N.] Univ Calif Irvine, Sch Med, Irvine, CA 92717 USA. [Ourmanov, Ilnour; Hirsch, Vanessa M.] NIAID, Bethesda, MA 20892 USA. [Carville, Angela; Mansfield, Keith G.] New England Primate Res Ctr, Southborough, MA 01772 USA. [Stablein, Donald] EMMES Corp, Rockville, MD 20850 USA. [Pau, Maria G.; Schuitemaker, Hanneke; Sadoff, Jerald C.; Goudsmit, Jaap] Crucell Holland BV, NL-2301 CA Leiden, Netherlands. [Billings, Erik A.; Rao, Mangala; Robb, Merlin L.; Kim, Jerome H.; Marovich, Mary A.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA. RP Barouch, DH (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02215 USA. EM dbarouch@bidmc.harvard.edu RI Ferrari, Guido/A-6088-2015 FU US Military Research and Material Command; US Military HIV Research Program [W81XWH-07-2-0067]; Ragon Institute of MGH, MIT and Harvard; National Institutes of Health [AI066924, AI078526, AI084794, AI095985, AI060354, AI002642, RR000168]; Bill and Melinda Gates Foundation FX We thank M. Pensiero, A. Fauci, E. Borducchi, S. Clark, R. Hamel, S. King, P. Kozlowski, A. La Porte, G. Landucci, A. Oza, J. Perry, L. Peter, A. Riggs, G. Shaw, N. Simmons, K. Smith, K. Stanley, F. Stephens, Y.-H. Sun, G. Weverling and E. Zablowsky for advice, assistance and reagents. We thank L. Picker, G. Silvestri and B. Walker for critically reviewing this manuscript. The SIVMAC239 peptide pools were obtained from the NIH AIDS Research and Reference Reagent Program. We acknowledge support from the US Military Research and Material Command and the US Military HIV Research Program (W81XWH-07-2-0067); the Ragon Institute of MGH, MIT and Harvard; the National Institutes of Health (AI066924, AI078526, AI084794, AI095985, AI060354, AI002642, RR000168); and the Bill and Melinda Gates Foundation. The opinions in this manuscript are those of the authors and do not reflect the views of the US Department of Defense. NR 30 TC 257 Z9 262 U1 4 U2 33 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 J9 NATURE JI Nature PD FEB 2 PY 2012 VL 482 IS 7383 BP 89 EP U115 DI 10.1038/nature10766 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 884RN UT WOS:000299726000041 PM 22217938 ER PT J AU Ellsworth, R Campbell, J Voeghtly, L Shriver, CD AF Ellsworth, R. Campbell, J. Voeghtly, L. Shriver, C. D. TI Molecular Alterations Associated with Early Breast Cancer Mortality SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 65th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO) CY MAR 21-24, 2012 CL Orlando, FL SP Soc Surg Oncol (SSO) C1 [Ellsworth, R.] Henry M Jackson Fdn Adv Mil Med, Windber, PA USA. [Voeghtly, L.] Windber Res Inst, Windber, PA USA. [Campbell, J.; Shriver, C. D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2012 VL 19 SU 1 BP S76 EP S76 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 025PE UT WOS:000310202700208 ER PT J AU Ellsworth, R Van Laar, R Deyarmin, B Shriver, C AF Ellsworth, R. Van Laar, R. Deyarmin, B. Shriver, C. TI Effect of ASCO/CAP Guidelines for Determining ER Status on Molecular Subtype SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 65th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO) CY MAR 21-24, 2012 CL Orlando, FL SP Soc Surg Oncol (SSO) C1 [Ellsworth, R.] Henry M Jackson Fdn Adv Mil Med, Windber, PA USA. [Van Laar, R.] ChipDx, New York, NY USA. [Deyarmin, B.] Windber Res Inst, Windber, PA USA. [Shriver, C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2012 VL 19 SU 1 BP S12 EP S12 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 025PE UT WOS:000310202700021 ER PT J AU Henry, LR Helou, LB Solomon, NP Chang, A Libutti, S Stojadinovic, A AF Henry, L. R. Helou, L. B. Solomon, N. P. Chang, A. Libutti, S. Stojadinovic, A. TI Technical Variations in the Conduct of Thyroidectomy and Parathyroidectomy Amongst Surgeons - A Survey Study SO ANNALS OF SURGICAL ONCOLOGY LA English DT Meeting Abstract CT 65th Annual Cancer Symposium of the Society-of-Surgical-Oncology (SSO) CY MAR 21-24, 2012 CL Orlando, FL SP Soc Surg Oncol (SSO) C1 [Henry, L. R.] Indiana Univ Hlth, Goshen Ctr Canc Care, Goshen, IN USA. [Helou, L. B.] Univ Pittsburgh, Pittsburgh, PA USA. [Solomon, N. P.; Chang, A.; Stojadinovic, A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Libutti, S.] Montefiore Med Ctr, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD FEB PY 2012 VL 19 SU 1 BP S112 EP S112 PG 1 WC Oncology; Surgery SC Oncology; Surgery GA 025PE UT WOS:000310202700322 ER PT J AU Theeler, BJ Erickson, JC AF Theeler, Brett J. Erickson, Jay C. TI Posttraumatic Headache in Military Personnel and Veterans of the Iraq and Afghanistan Conflicts SO CURRENT TREATMENT OPTIONS IN NEUROLOGY LA English DT Review DE Headache disorders; Military personnel; Traumatic brain injury; Concussion; Treatment; Management; Assessment; Headaches; Migraine; Posttraumatic headache; NSAIDs; Triptans; Topiramate; Prophylaxis ID TRAUMATIC BRAIN-INJURY; US SOLDIERS; CHRONIC MIGRAINE; STRESS-DISORDER; PREVALENCE; IMPACT; NECK; CONCUSSION; MEDICATION; SEVERITY AB Headaches, particularly migraine, are common in US servicemembers (SMs) who are deployed to or have returned from theaters of combat operations in Iraq and Afghanistan. Concussions and exposure to explosive blasts may be a significant contributor to the increased prevalence of headaches in military veterans. Concussions, usually due to blast exposure, occur in approximately 20% of deployed SMs, and headaches are a common symptom after a deployment-related concussion. Posttraumatic headaches (PTHAs) in US SMs usually resemble migraines, and posttraumatic stress disorder (PTSD) and depression are common comorbidities. Treatment of PTHAs in SMs is based upon the treatment setting, whether the headaches are acute or chronic, the headache phenotype, and associated comorbidities. No randomized, controlled clinical trials evaluating the efficacy of therapies for PTHAs have been completed. Pharmacologic and nonpharmacologic management strategies should be selected on an individual basis. Acute therapy with NSAIDs or triptans and prophylactic therapy in acute and chronic settings using valproate, nortriptyline, amitriptyline, propranolol, topiramate, or botulinum toxin are discussed. Triptans and topiramate may be particularly effective in SMs with PTHA. Management of PTHA and other features of the posttraumatic syndrome should be multidisciplinary whenever possible. C1 [Theeler, Brett J.; Erickson, Jay C.] USA, Med Corps, Ft Sam Houston, TX USA. [Theeler, Brett J.] AMEDD Student Detachment, Med Battal 187, Ft Sam Houston, TX USA. [Erickson, Jay C.] Madigan Army Med Ctr, Neurol Serv, Dept Med, Ft Lewis, WA USA. RP Theeler, BJ (reprint author), USA, Med Corps, Ft Sam Houston, TX USA. EM btheeler@hotmail.com; jay.erickson@us.army.mil NR 57 TC 13 Z9 13 U1 2 U2 12 PU CURRENT MEDICINE GROUP PI PHILADELPHIA PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA SN 1092-8480 J9 CURR TREAT OPTION NE JI Curr. Treat. Options Neurol. PD FEB PY 2012 VL 14 IS 1 BP 36 EP 49 DI 10.1007/s11940-011-0157-2 PG 14 WC Clinical Neurology SC Neurosciences & Neurology GA 945ZO UT WOS:000304317100004 PM 22116663 ER PT J AU Marble, S AF Marble, Sanders TI Brigadier General James Stevens Simmons (1890-1954), Medical Corps, United States Army: a career in preventive medicine SO JOURNAL OF MEDICAL BIOGRAPHY LA English DT Article AB James Simmons began his career in the US Army as a laboratory officer and his assignments progressed into tropical medicine research. His interests and work evolved into preventive medicine (PM, as the Army termed public health), and he took both a PhD and a Doctorate in Public Health. As the Army's leading PM officer he was appointed head of PM in 1940 and guided the Army's PM effort through World War II. His responsibility ran from gas masks through healthy nutrition and occupational health to an enormous variety of diseases; by the war's end, the breadth and importance of PM was reflected in the Preventive Medicine Division, having fully one-sixth of all military personnel at the Surgeon General's Office. Simmons used his strong professional credentials to tap into civilian medicine for expertise the Army lacked and he established organizations that survive to this day. After retirement, he sought to expand the field of public health and raise another generation of public health physicians. C1 [Marble, Sanders] USA, Off Med Hist, Ft Sam Houston, TX 78234 USA. [Marble, Sanders] Walter Reed Army Med Ctr, Smithsonian Inst, Washington, DC USA. RP Marble, S (reprint author), USA, Off Med Hist, 2050 Worth Rd, Ft Sam Houston, TX 78234 USA. EM sanders.marble@us.army.mil NR 24 TC 0 Z9 0 U1 0 U2 0 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0967-7720 J9 J MED BIOGR JI J. Med. Biogr. PD FEB PY 2012 VL 20 IS 1 BP 3 EP 10 DI 10.1258/jmb.2010.010054 PG 8 WC History & Philosophy Of Science SC History & Philosophy of Science GA 936ZD UT WOS:000303627900002 PM 22499600 ER PT J AU Blaylock, JM Byers, DK Gibbs, BT Nayak, G Ferguson, M Tribble, DR Porter, C Decker, CF AF Blaylock, J. M. Byers, D. K. Gibbs, B. T. Nayak, G. Ferguson, M. Tribble, D. R. Porter, C. Decker, C. F. TI Longitudinal assessment of cardiac diastolic function in HIV-infected patients SO INTERNATIONAL JOURNAL OF STD & AIDS LA English DT Article DE HIV infection; cardiac; cardiovascular disease; diastolic dysfunction; echocardiography ID RECEIVING ANTIRETROVIRAL THERAPY; ENDOTHELIAL ACTIVATION MARKERS; MYOCARDIAL-INFARCTION; COLLABORATIVE ANALYSIS; HEART-FAILURE; CARDIOVASCULAR-DISEASE; CLINICAL-TRIALS; RISK-FACTORS; DYSFUNCTION; PREVALENCE AB Asymptomatic isolated diastolic dysfunction (DD), with normal left ventricular systolic function, may be the first indication of underlying cardiac disease in HIV-negative populations. We previously reported a high prevalence (37%) of DD among asymptomatic HIV-infected patients at low risk for AIDS and cardiovascular disease (CVD). We performed a longitudinal assessment of interval echocardiographic changes in this cohort over a four-year period. Repeat transthoracic echocardiograms (TTEs) utilized standard techniques. Sixty (of the original 91) HIV-infected patients, predominately men, underwent repeat TTE (median follow-up 3.7 years, interquartile range [IQR] 3.5, 4.0). Cohort characteristics (median; IQR) include age 42.0 (36.5, 46.0) years, HIV duration 16.4 years (8.1, 18.9), current CD4 count 572.0 cells/mm(3) (436.5, 839.0), antiretroviral therapy (ART) duration 8.1 years,(4.8, 13.4) and Framingham risk score 1.0 (0.0, 2.0). DD was observed in 28/60 patients on re-evaluation (47%, 95% confidence interval [CI] 34%, 60%); 31% (11/36) of patients had new onset DD for an overall incidence of 8.2/100 person-years. On follow-up, subjects with DD were older, had a trend towards higher body mass index, hypertension and longer duration of HIV infection compared with subjects: without DD. We confirmed a high prevalence of DD (47%) in asymptomatic HIV-infected patients at low risk for AIDS and CVD. C1 [Decker, C. F.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD 20889 USA. [Blaylock, J. M.; Gibbs, B. T.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Tribble, D. R.] Infect Dis Clin Res Program, Bethesda, MD USA. [Tribble, D. R.; Decker, C. F.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Porter, C.] USN, Med Res Ctr, Silver Spring, MD USA. RP Decker, CF (reprint author), Natl Naval Med Ctr, Div Infect Dis, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Catherine.Decker@med.navy.mil NR 42 TC 5 Z9 5 U1 0 U2 1 PU ROYAL SOC MEDICINE PRESS LTD PI LONDON PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND SN 0956-4624 J9 INT J STD AIDS JI Int. J. STD AIDS PD FEB PY 2012 VL 23 IS 2 BP 105 EP 110 DI 10.1258/ijsa.2011.011099 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 929WK UT WOS:000303096200006 PM 22422684 ER PT J AU Sadler, JM Nguyen, AP Greer, SM Palmese, GR La Scala, JJ AF Sadler, Joshua M. Anh-Phuong Nguyen Greer, Sylvester M. Palmese, Giuseppe R. La Scala, John J. TI Synthesis and Characterization of a Novel Bio-Based Reactive Diluent as a Styrene Replacement SO JOURNAL OF BIOBASED MATERIALS AND BIOENERGY LA English DT Article DE Bio-Based; Carbohydrate-Based; Furanic; Reactive Diluent; Resin; Vinyl Ester; Thermoset; HAP Reduction; VOC Reduction; Renewable ID VINYL-ESTER RESINS; INFRARED SPECTROSCOPY; MONOMERS; NETWORKS; POLYMERS AB Recent years has seen a shift towards the use of composite materials in a number of applications due to their improved attributes when compared to traditional building materials. Vinyl ester and unsaturated polyester resins require the use of reactive diluents, such as styrene and methyl methacrylate, for liquid molding manufacture of composites. However, these diluents are hazardous air pollutants (HAP) and volatile organic compounds (VOC) and are emitted during every phase of production. This work focuses on the formulation of a novel bio-based reactive diluents for vinyl ester resins in an effort to reduce emissions while maintaining the properties of styrene-based systems. A novel furanic reactive diluent, furoic acid glycidyl methacrylate (FA-GM), was synthesized from bio-based starting materials and then blended with a vinyl ester cross-linker in order to study the potential as a styrene replacement. VE resin blends using FA-GM and another furanic reactive diluent were found to have higher viscosities (4-234 cP) and lower glass transition temperatures (82-100 degrees C) relative to styrene-based vinyl esters. C1 [Sadler, Joshua M.; Anh-Phuong Nguyen; La Scala, John J.] USA, RDRL WMM C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Greer, Sylvester M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA. RP La Scala, JJ (reprint author), USA, RDRL WMM C, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM john.j.lascala.civ@mail.mil FU U.S. Department of Defense [SERDP WP-1758]; U.S. Army Research Laboratory FX The authors would like to thank Cytec Industries for providing the RDX-26936 (methacrylated epoxy) vinyl ester; Applied Poleramics Incorporated (API) for providing Mlau. This research was supported by the U.S. Department of Defense, through the Strategic Environmental Research and Development Program (SERDP WP-1758). This research was also supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 22 TC 8 Z9 8 U1 1 U2 38 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 1556-6560 J9 J BIOBASED MATER BIO JI J. Biobased Mater. Bioenergy PD FEB PY 2012 VL 6 IS 1 BP 86 EP 93 DI 10.1166/jbmb.2012.1193 PG 8 WC Chemistry, Applied; Energy & Fuels; Materials Science, Biomaterials SC Chemistry; Energy & Fuels; Materials Science GA 932GW UT WOS:000303279500009 ER PT J AU Dickens, JF Kilcoyne, KG Haniuk, E Owens, BD AF Dickens, Jonathan F. Kilcoyne, Kelly G. Haniuk, Erik Owens, Brett D. TI Combined Lesions of the Glenoid Labrum SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article DE shoulder; instability; labrum; Bankart ID ANTERIOR SHOULDER DISLOCATIONS; ARTHROSCOPIC REPAIR; BIOMECHANICAL MODEL; FOLLOW-UP; INSTABILITY; STABILIZATION; BANKART; JOINT; CLASSIFICATION; STABILITY AB Advances in shoulder arthroscopy and improved understanding of the pathoanatomy following shoulder instability have led to increased recognition of combined lesions of the glenoid labrum. Although the diagnosis of combined labral tears is often made with physical examination and magnetic resonance imaging, combined tears can be discovered intraoperatively. A high index of suspicion is necessary, especially in the setting of chronic recurrent shoulder instability or previous failed labral repair. Over a 6-year period at a military institution, combined labral repairs comprised 37% of all patients undergoing any labral repair. With accurate identification of all labral pathology and a systematic approach to labral repair, successful outcomes can be achieved. C1 [Haniuk, Erik; Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. [Dickens, Jonathan F.; Kilcoyne, Kelly G.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed, Washington, DC USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 33 TC 4 Z9 4 U1 0 U2 0 PU JTE MULTIMEDIA PI BERWYN PA 1235 WESTLAKES DR, STE 220, BERWYN, PA 19312 USA SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD FEB PY 2012 VL 40 IS 1 BP 102 EP 108 DI 10.3810/psm.2012.02.1956 PG 7 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA 934CO UT WOS:000303419500018 PM 22508256 ER PT J AU Edwards, G Kitzmiller, RR Breckenridge-Sproat, S AF Edwards, Gina Kitzmiller, Rebecca R. Breckenridge-Sproat, Sara TI Innovative Health Information Technology Training Exploring Blended Learning SO CIN-COMPUTERS INFORMATICS NURSING LA English DT Article DE Blended learning; Health information technology; Hospital; Satisfaction; Training ID PHYSICIAN ORDER ENTRY; SYSTEM; IMPLEMENTATION; CARE; MANAGEMENT AB Healthcare staff members are faced with an ever-increasing technology-enabled care environment as hospitals respond to financial and regulatory pressures to implement comprehensive electronic health record systems. Health information technology training may prove to facilitate user acceptance and overall adoption of advanced technologies. However, there is little evidence regarding best methods of providing health information technology training. This study retrospectively examined the difference in staff satisfaction between two training methods: traditional instructor-led and blended learning and found that participants were equally satisfied with either method. Furthermore, regardless of how much time was provided for practice, participants expressed a desire for more. These findings suggest that healthcare staff are open to new methods of training delivery and that, as adult learners, they desire increased opportunities to engage in hands-on activities. C1 [Kitzmiller, Rebecca R.] Duke Univ, Sch Nursing, Apex, NC 27502 USA. [Edwards, Gina] Duke Univ Hlth Syst, Durham, NC USA. [Breckenridge-Sproat, Sara] USA Nurse Corps, Ctr Nursing Sci & Clin Inquiry, Walter Reed Army Med Ctr, Washington, DC USA. RP Kitzmiller, RR (reprint author), Duke Univ, Sch Nursing, 104 Witheridge Ct, Apex, NC 27502 USA. EM kitzm002@mc.duke.edu FU Duke Health Technologies Solutions of Duke University Health System; Duke University School of Nursing FX This study and RK's salary was funded through two sources: a fellowship from Duke Health Technologies Solutions of Duke University Health System and Duke University School of Nursing. NR 32 TC 7 Z9 8 U1 3 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1538-2931 J9 CIN-COMPUT INFORM NU JI CIN-Comput. Inform. Nurs. PD FEB PY 2012 VL 30 IS 2 BP 104 EP 109 DI 10.1097/NCN.0b013e31822f7f7a PG 6 WC Computer Science, Interdisciplinary Applications; Medical Informatics; Nursing SC Computer Science; Medical Informatics; Nursing GA 921MN UT WOS:000302481800006 PM 21915046 ER PT J AU Karlan, BY Oza, AM Richardson, GE Provencher, DM Hansen, VL Buck, M Chambers, SK Ghatage, P Pippitt, CH Brown, JV Covens, A Nagarkar, RV Davy, M Leath, CA Nguyen, H Stepan, DE Weinreich, DM Tassoudji, M Sun, YN Vergote, IB AF Karlan, Beth Y. Oza, Amit M. Richardson, Gary E. Provencher, Diane M. Hansen, Vincent L. Buck, Martin Chambers, Setsuko K. Ghatage, Prafull Pippitt, Charles H., Jr. Brown, John V., III Covens, Allan Nagarkar, Raj V. Davy, Margaret Leath, Charles A., III Hoa Nguyen Stepan, Daniel E. Weinreich, David M. Tassoudji, Marjan Sun, Yu-Nien Vergote, Ignace B. TI Randomized, Double-Blind, Placebo-Controlled Phase II Study of AMG 386 Combined With Weekly Paclitaxel in Patients With Recurrent Ovarian Cancer SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID GYNECOLOGIC-ONCOLOGY-GROUP; ADVANCED SOLID TUMORS; GASTROINTESTINAL PERFORATION; CLINICAL-TRIAL; BEVACIZUMAB; ANGIOGENESIS; CHEMOTHERAPY; GROWTH; CA-125; ANGIOPOIETIN-2 AB Purpose To estimate the efficacy and toxicity of AMG 386, an investigational peptide-Fc fusion protein that neutralizes the interaction between the Tie2 receptor and angiopoietin-1/2, plus weekly paclitaxel in patients with recurrent ovarian cancer. Patients and Methods Patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer were randomly assigned 1: 1: 1 to receive paclitaxel (80 mg/m(2) once weekly [QW], 3 weeks on/1 week off) plus intravenous AMG 386 10 mg/kg QW (arm A), AMG 386 3 mg/kg QW (arm B), or placebo QW (arm C). The primary end point was progression-free survival (PFS). Secondary end points included overall survival, objective response, CA-125 response, safety, and pharmacokinetics. Results One hundred sixty-one patients were randomly assigned. Median PFS was 7.2 months (95% CI, 5.3 to 8.1 months) in arm A, 5.7 months (95% CI, 4.6 to 8.0 months) in arm B, and 4.6 months (95% CI, 1.9 to 6.7 months) in arm C. The hazard ratio for arms A and B combined versus arm C was 0.76 (95% CI, 0.52 to 1.12; P = .165). Further analyses suggested an exploratory dose-response effect for PFS across arms (Tarone's test, P = .037). Objective response rates for arms A, B, and C were 37%, 19%, and 27%, respectively. The incidence of grade >= 3 adverse events (AEs) in arms A, B, and C was 65%, 55%, and 64%, respectively. Frequent AEs included hypertension (8%, 6%, and 5% in arms A, B, and C, respectively), peripheral edema (71%, 51%, and 22% in arms A, B, and C, respectively), and hypokalemia (21%, 15%, and 5% in arms A, B, and C, respectively). AMG 386 exhibited linear pharmacokinetic properties at the tested doses. Conclusion AMG 386 combined with weekly paclitaxel was tolerable, with a manageable and distinct toxicity profile. The data suggest evidence of antitumor activity and a dose-response effect, warranting further studies in ovarian cancer. J Clin Oncol 30: 362-371. (C) 2011 by American Society of Clinical Oncology C1 [Karlan, Beth Y.] Cedars Sinai Med Ctr, Div Gynecol Oncol, Los Angeles, CA 90048 USA. [Brown, John V., III] Gynecol Oncol Associates, Newport Beach, CA USA. [Stepan, Daniel E.; Weinreich, David M.; Sun, Yu-Nien] Amgen Inc, Thousand Oaks, CA USA. [Tassoudji, Marjan] Amgen Inc, San Francisco, CA USA. [Hansen, Vincent L.] No Utah Associates, Ogden, UT USA. [Chambers, Setsuko K.] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA. [Pippitt, Charles H., Jr.] Piedmont Hematol Oncol Associates, Winston Salem, NC USA. [Leath, Charles A., III] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hoa Nguyen] Sheridan Healthcare Corp, Hollywood, FL USA. [Covens, Allan] Toronto Sunnybrook Reg Canc Ctr, Toronto, ON, Canada. [Provencher, Diane M.] Hop Notre Dame De Bon Secours, Ctr Hosp Univ Montreal, Montreal, PQ, Canada. [Ghatage, Prafull] Tom Baker Canc Clin, Calgary, AB, Canada. [Buck, Martin] Sir Charles Gairdner Hosp, Perth, WA 6000, Australia. [Richardson, Gary E.] Cabrini Hosp, Melbourne, Vic, Australia. [Davy, Margaret] Royal Adelaide Hosp, Adelaide, SA 5000, Australia. [Nagarkar, Raj V.] Curie Manavata Canc Ctr, Nasik, Maharashtra, India. [Vergote, Ignace B.] Univ Hosp Leuven, Louvain, Belgium. RP Karlan, BY (reprint author), Cedars Sinai Med Ctr, Div Gynecol Oncol, Los Angeles, CA 90048 USA. EM Beth.Karlan@cshs.org OI Leath III, Charles/0000-0002-4034-6845 FU Amgen [AMG386 Study] FX Research Funding: Beth Y. Karlan, Amgen; Gary E. Richardson, Amgen - AMG386 Study, Amgen - Denosumab Studies; Vincent L. Hansen, Amgen; John V. Brown III, Amgen; Charles A. Leath III, Amgen NR 35 TC 111 Z9 113 U1 1 U2 10 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD FEB 1 PY 2012 VL 30 IS 4 BP 362 EP 371 DI 10.1200/JCO.2010.34.3178 PG 10 WC Oncology SC Oncology GA 923LN UT WOS:000302620900014 PM 22184370 ER PT J AU Toblin, RL Riviere, LA Thomas, JL Adler, AB Kok, BC Hoge, CW AF Toblin, Robin L. Riviere, Lyndon A. Thomas, Jeffrey L. Adler, Amy B. Kok, Brian C. Hoge, Charles W. TI Grief and physical health outcomes in US soldiers returning from combat SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE Military; Grief; Epidemiology; Somatic symptoms; Occupational functioning ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; SELF-REPORTED SYMPTOMS; PERSIAN-GULF-WAR; COMPLICATED GRIEF; SOMATIC SYMPTOMS; IRAQ WAR; VETERANS; DEPRESSION; CARE AB Background: Few studies have measured the burden of physical health problems after Iraq/Afghanistan deployment, except in association with post-traumatic stress disorder (PTSD) or mild traumatic brain injury (mTBI). Grief, a correlate of health problems in the general population, has not been systematically examined. We aimed to identify the prevalence of post-deployment physical health problems and their association with difficulty coping with grief. Methods: Infantry soldiers (n=1522) completed anonymous surveys using validated instruments six months following deployment in November-December 2008. Multiple logistic regression was used to assess the association of difficulty coping with grief and physical health. Results: The most frequent physical health symptoms reported were: sleep problems (32.8%), musculoskeletal pain (32.7%), fatigue (32.3%), and back pain (28.1%). Difficulty coping with grief over the death of someone close affected 21.3%. There was a dose-response relationship between level of difficulty coping with grief and principal physical health outcomes (ps<.002). Controlling for demographics, combat experiences, injuries, PTSD, depression, and other factors, grief significantly and uniquely contributed to a high somatic symptom score (adjusted odds ratio (AOR)=3.6), poor general health (AOR=2.0), missed work (AOR=1.7), medical utilization (AOR=1.5), difficulty carrying a heavy load (AOR=1.7), and difficulty performing physical training (AOR=1.6; all 95% confidence intervals > 1). Limitations: Data are cross-sectional and grief was measured with one item. Conclusions: Over 20% of soldiers reported difficulty coping with grief. This difficulty was significantly associated with physical health outcomes and occupational impairment Clinicians should be aware of the unique role grief plays in post-deployment physical health when treating patients. Published by Elsevier B.V. C1 [Toblin, Robin L.; Riviere, Lyndon A.; Thomas, Jeffrey L.; Kok, Brian C.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, Silver Spring, MD 20910 USA. [Adler, Amy B.] US Army Med Res Unit Europe, D-69126 Heidelberg, Germany. RP Toblin, RL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM robin.l.toblin@us.army.mil RI Schueter, nicos/A-3625-2014 FU U.S. Army Medical Research and Materiel Command (MRMC) FX We accomplished this work entirely using internal funding supplied by the U.S. Army Medical Research and Materiel Command (MRMC). MRMC's Research Area Directorate III: Interventions to Enhance Psychological Resilience and Prevent Psychiatric Casualties is the funding mechanism. MRMC did not have any role in writing the manuscript or the decision to submit it for publication and did not pay us to write the article. NR 32 TC 31 Z9 32 U1 1 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD FEB PY 2012 VL 136 IS 3 BP 469 EP 475 DI 10.1016/j.jad.2011.10.048 PG 7 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 915AT UT WOS:000301996000035 PM 22154707 ER PT J AU Fischer, RA Gauthreaux, SA Valente, JJ Guilfoyle, MP Kaller, MD AF Fischer, Richard A. Gauthreaux, Sidney A., Jr. Valente, Jonathon J. Guilfoyle, Michael P. Kaller, Michael D. TI Comparing transect survey and WSR-88D radar methods for monitoring daily changes in stopover migrant communities SO JOURNAL OF FIELD ORNITHOLOGY LA English DT Article DE avian migration; NEXRAD; riparian; stopover; transect surveys; WSR-88D weather radar ID LANDBIRDS; BIRDS; CONSERVATION; ARIZONA AB For decades, researchers have successfully used ground-based surveys to understand localized spatial and temporal patterns in stopover habitat use by migratory birds. Recent technological advances with WSR-88D radar now allow such investigations on much broader spatial scales. Both methods are assumed to accurately quantify patterns in migrant bird communities, yet information is lacking regarding relationships between radar estimates of migration and different ground-based monitoring methods. From 2005 to 2007, we monitored migrant communities on or near two Department of Defense installations in the spring (Ft. Polk Military Complex, LA; U.S. Army Test and Evaluation Command, Yuma Proving Ground, AZ) and on two installations in the fall (Ft. Polk Military Complex, LA; Eglin Air Force Base, FL) using both ground-based transect surveys and radar imagery of birds aloft. We modeled daily changes in migrant abundance and positive and negative species turnover measured on the ground as a function of radar estimates of migrant exodus and input densities. Radar data were not significant predictors of any response variable in any season either in the southeastern or southwestern United States, indicating a disparity between the results obtained using different methods. Multiple unique sources of error associated with each technique likely contributed to the conflicting outcomes, and researchers should take great care when selecting monitoring methods appropriate to address research questions, effects of management practices, or when comparing the results of migration studies using different survey techniques. C1 [Fischer, Richard A.; Valente, Jonathon J.; Guilfoyle, Michael P.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Gauthreaux, Sidney A., Jr.] Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA. [Kaller, Michael D.] Louisiana State Univ, Ctr Agr, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA. RP Valente, JJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM jonathon.j.valente@gmail.com FU Department of Defense Strategic Environmental Research and Development Program (SERDP) FX This research was conducted under contract to the Department of Defense Strategic Environmental Research and Development Program (SERDP). The publication of this paper does not indicate endorsement by the Department of Defense, nor should the contents be construed as reflecting the official policy or position of the Department of Defense. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the Department of Defense. We thank G. A. Gudmundsson and one anonymous reviewer for helpful comments on earlier versions of the manuscript. NR 37 TC 5 Z9 5 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0273-8570 EI 1557-9263 J9 J FIELD ORNITHOL JI J. Field Ornithol. PD FEB PY 2012 VL 83 IS 1 BP 61 EP 72 DI 10.1111/j.1557-9263.2011.00356.x PG 12 WC Ornithology SC Zoology GA 898TV UT WOS:000300765600008 ER PT J AU Shakarian, P Roos, P Johnson, A AF Shakarian, Paulo Roos, Patrick Johnson, Anthony TI A review of evolutionary graph theory with applications to game theory SO BIOSYSTEMS LA English DT Review DE Evolutionary dynamics; Structured populations; Game theory; Fixation probability; Time to fixation ID STRUCTURED POPULATIONS; SPATIAL STRUCTURE; DYNAMICS; NETWORKS; FIXATION; COOPERATION; STABILITY; SELECTION; FITNESS AB Evolutionary graph theory (EGT), studies the ability of a mutant gene to overtake a finite structured population. In this review, we describe the original framework for EGT and the major work that has followed it. This review looks at the calculation of the "fixation probability" - the probability of a mutant taking over a population and focuses on game-theoretic applications. We look at varying topics such as alternate evolutionary dynamics, time to fixation, special topological cases, and game theoretic results. Throughout the review, we examine several interesting open problems that warrant further research. Published by Elsevier Ireland Ltd. C1 [Shakarian, Paulo; Johnson, Anthony] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. [Shakarian, Paulo] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Roos, Patrick] Univ Maryland, Dept Comp Sci, College Pk, MD 20740 USA. [Johnson, Anthony] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Shakarian, P (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. EM paulo@shakarian.net FU ARO [611102B74F]; Office of the Secretary of Defense (OSD); AFOSR [FA95500610405]; NAVAIR [N6133906C0149] FX P.S. and A.J. are supported by ARO grant 611102B74F as well as the Office of the Secretary of Defense (OSD).; P.R. is supported by AFOSR grant FA95500610405 and NAVAIR contract N6133906C0149. The opinions in this paper are those of the authors and do not necessarily reflect the opinions of the funders. NR 57 TC 49 Z9 50 U1 5 U2 52 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0303-2647 EI 1872-8324 J9 BIOSYSTEMS JI Biosystems PD FEB PY 2012 VL 107 IS 2 BP 66 EP 80 DI 10.1016/j.biosystems.2011.09.006 PG 15 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA 917OY UT WOS:000302188900002 PM 22020107 ER PT J AU Wilkinson, IM Cohen, SP AF Wilkinson, Indy M. Cohen, Steven P. TI Epidural Steroid Injections SO CURRENT PAIN AND HEADACHE REPORTS LA English DT Review DE Epidural steroid injection; Transforaminal epidural steroid injection; Interlaminar epidural steroid injection; Neuropathic spinal pain; Radiculopathy; Sciatica; Low back pain; Disability; Cost-effectiveness; Anesthesia; Pain management ID LOW-BACK-PAIN; LUMBAR RADICULAR PAIN; CERVICAL TRANSFORAMINAL INJECTION; RANDOMIZED CONTROLLED-TRIAL; NERVE ROOT COMPRESSION; DISK-RELATED SCIATICA; NEUROPATHIC PAIN; SPINAL STENOSIS; CORTICOSTEROID INJECTION; ASYMPTOMATIC SUBJECTS AB Epidural steroid injection (ESI) is the most commonly performed intervention in pain clinics across the United States. This article provides an evidence-based review of ESI, including data on efficacy, patient selection, comparison of types, and complications. The data strongly suggest that ESI can provide short-term relief for radicular symptoms but are less compelling for long-term effects or relief of back pain. Although it has been asserted that transforaminal ESIs are more efficacious than interlaminar injections, the evidence supporting this is limited. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Pain Management Div, Dept Anesthesiol, Baltimore, MD 21029 USA. [Wilkinson, Indy M.; Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Cohen, SP (reprint author), Johns Hopkins Sch Med, Pain Management Div, Dept Anesthesiol, 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU Centers for Rehabilitation Sciences Research (Washington, D.C.); Defense & Veterans Pain Management Initiative (Bethesda, MD) FX Dr. Steven P. Cohen is funded by the Centers for Rehabilitation Sciences Research (Washington, D.C.) and the Defense & Veterans Pain Management Initiative (Bethesda, MD) NR 103 TC 16 Z9 16 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1531-3433 EI 1534-3081 J9 CURR PAIN HEADACHE R JI Curr. Pain Headache Rep. PD FEB PY 2012 VL 16 IS 1 BP 50 EP 59 DI 10.1007/s11916-011-0236-9 PG 10 WC Clinical Neurology SC Neurosciences & Neurology GA 914TZ UT WOS:000301976800007 PM 22090263 ER PT J AU Knuth, MA Johnson, JB Hopkins, MA Sullivan, RJ Moore, JM AF Knuth, M. A. Johnson, J. B. Hopkins, M. A. Sullivan, R. J. Moore, J. M. TI Discrete element modeling of a Mars Exploration Rover wheel in granular material SO JOURNAL OF TERRAMECHANICS LA English DT Article DE Mars Exploration Rover; Discrete element method; Triaxial test; Lunar regolith simulant AB Three-dimensional discrete element method (DEM) simulations were developed for the Mars Exploration Rover (MER) mission to investigate: (1) rover wheel interactions with martian regolith; and (2) regolith deformation in a geotechnical triaxial strength cell (GTSC). These DEM models were developed to improve interpretations of laboratory and in situ rover data, and can simulate complicated regolith conditions. A DEM simulation was created of a laboratory experiment that involved a MER wheel digging into lunar regolith simulant. Sinkage and torques measured in the experiment were compared with those predicted numerically using simulated particles of increasing shape complexity (spheres, ellipsoids, and poly-ellipsoids). GTSC simulations, using the same model regolith used in the MER simulations, indicate a peak friction angle of approximately 37-38 degrees compared to internal friction angles of 36.5-37.7 degrees determined from the wheel digging experiments. Density of the DEM regolith was 1820 kg/m(3) compared to 1660 kg/m(3) for the lunar simulant used in the wheel digging experiment indicating that the number of grain contacts and grain contact resistance determined bulk strength in the DEM simulations, not density. An improved correspondence of DEM and actual test regolith densities is needed to simulate the evolution of regolith properties as density changes. Published by Elsevier Ltd. on behalf of ISTVS. C1 [Knuth, M. A.; Hopkins, M. A.] USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Johnson, J. B.] Univ Alaska Fairbanks, Inst No Engn, Fairbanks, AK 99775 USA. [Sullivan, R. J.] Cornell Univ, Ctr Radiophys & Space Res, Ithaca, NY 14853 USA. [Moore, J. M.] NASA, Ames Res Ctr, Div Space Sci, Moffett Field, CA 94035 USA. RP Knuth, MA (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Margaret.A.Knuth@usace.army.mil; jbjohnson5@alaska.edu; Mark.A.Hopkins@usace.army.mil; rjs33@cornell.edu; jeffmoore@nasa.gov FU NASA Lunar Science Institute; NASA's Kennedy Space Center; NASA MERPS [NNH05ZDA001N] FX This work was supported by the NASA Lunar Science Institute supported project "Scientific Exploration Potential of the Lunar Poles", NASA's Kennedy Space Center Technology Development project "Lunar regolith mechanical properties, the NASA's Mars Fundamental Research Program project "The relationship between the physical and mechanical properties of Mars soils and their simulation", and the NASA Mars Exploration Rover Program-NNH05ZDA001N-MERPS project "Physical and geologic Investigations of the surface materials along the MER traverses. NR 23 TC 20 Z9 21 U1 1 U2 18 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD FEB PY 2012 VL 49 IS 1 BP 27 EP 36 DI 10.1016/j.terra.2011.09.003 PG 10 WC Engineering, Environmental SC Engineering GA 913TO UT WOS:000301900500003 ER PT J AU Elsayed, MA Neuber, AA Dickens, JC Walter, JW Kristiansen, M Altgilbers, LL AF Elsayed, M. A. Neuber, A. A. Dickens, J. C. Walter, J. W. Kristiansen, M. Altgilbers, L. L. TI An explosively driven high-power microwave pulsed power system SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB The increased popularity of high power microwave systems and the various sources to drive them is the motivation behind the work to be presented. A stand-alone, self-contained explosively driven high power microwave pulsed power system has been designed, built, and tested at Texas Tech University's Center for Pulsed Power and Power Electronics. The system integrates four different sub-units that are composed of a battery driven prime power source utilizing capacitive energy storage, a dual stage helical flux compression generator as the main energy amplification device, an integrated power conditioning system with inductive energy storage including a fast opening electro-explosive switch, and a triode reflex geometry virtual cathode oscillator as the microwave radiating source. This system has displayed a measured electrical source power level of over 5 GW and peak radiated microwaves of about 200 MW. It is contained within a 15 cm diameter housing and measures 2 m in length, giving a housing volume of slightly less than 39 1. The system and its sub-components have been extensively studied, both as integrated and individual units, to further expand on components behavior and operation physics. This report will serve as a detailed design overview of each of the four subcomponents and provide detailed analysis of the overall system performance and benchmarks. (C) 2012 American Institute of Physics. [doi:10.1063/1.3681443] C1 [Elsayed, M. A.; Neuber, A. A.; Dickens, J. C.; Walter, J. W.; Kristiansen, M.] Texas Tech Univ, Dept Elect & Comp Engn, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. [Elsayed, M. A.; Neuber, A. A.; Dickens, J. C.; Walter, J. W.; Kristiansen, M.] Texas Tech Univ, Dept Phys, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. [Altgilbers, L. L.] USA, SMDC, Huntsville, AL 35808 USA. RP Elsayed, MA (reprint author), Texas Tech Univ, Dept Elect & Comp Engn, Ctr Pulsed Power & Power Elect, Lubbock, TX 79409 USA. FU Center for Pulsed Power and Power Electronics lab at Texas Tech University FX Special thanks to Andrew Young, Charlie Anderson, and Shad Holt, and to the staff and technicians at the Center for Pulsed Power and Power Electronics lab at Texas Tech University for their tremendous support and effort put forth throughout this project. NR 24 TC 9 Z9 9 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD FEB PY 2012 VL 83 IS 2 AR 024705 DI 10.1063/1.3681443 PN 1 PG 11 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 909LS UT WOS:000301566600043 PM 22380111 ER PT J AU Torres, DM Harrison, SA AF Torres, Dawn M. Harrison, Stephen A. TI Nonalcoholic Steatohepatitis and Noncirrhotic Hepatocellular Carcinoma: Fertile Soil SO SEMINARS IN LIVER DISEASE LA English DT Review DE Nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; insulin resistance; hepatocellular carcinoma ID FATTY LIVER-DISEASE; NF-KAPPA-B; INSULIN-RECEPTOR SUBSTRATE-1; TOLL-LIKE RECEPTORS; GROWTH-FACTOR-I; DIABETES-MELLITUS; RISK-FACTORS; METABOLIC SYNDROME; STAT3 ACTIVATION; LIPID-METABOLISM AB Nonalcoholic fatty liver disease (NAFLD) is easily themost common cause of chronic liver disease in the United States (U. S.) as the hepatic manifestation of the metabolic syndrome. Although only 5 to 20% of patients with NAFLD are generally considered to meet criteria for nonalcoholic steatohepatitis (NASH), with its inherent risk for progression to cirrhosis, this still represents an alarmingly large number of individuals. The exponentially growing rates of hepatocellular carcinoma (HCC) in the U. S. may be partially attributable to increased numbers of NASH cirrhotics, although recent evidence has suggested that NAFLD may directly promote hepatic carcinogenesis independent of cirrhosis. This review focuses on HCC in noncirrhotic NASH with an emphasis on clinical presentation, pathogenesis, and implications for screening. C1 [Torres, Dawn M.] Walter Reed Natl Mil Med Ctr, Dept Med, Div Gastroenterol, Washington, DC USA. [Harrison, Stephen A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Dept Med, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil FU Genentech; Merck; BMS; Rottapharm; Mochida FX Dr. Harrison receives research support from Genentech, Merck, BMS, Rottapharm, and Mochida. He is a member of the Ad Hoc Advisory Board for Amylin Pharmaceuticals. NR 109 TC 50 Z9 53 U1 1 U2 12 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0272-8087 J9 SEMIN LIVER DIS JI Semin. Liver Dis. PD FEB PY 2012 VL 32 IS 1 BP 30 EP 38 DI 10.1055/s-0032-1306424 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 907SM UT WOS:000301438100005 PM 22418886 ER PT J AU Spinella, PC Strandenes, G Rein, EB Seghatchian, J Hervig, T AF Spinella, Philip C. Strandenes, Geir Rein, Erling Bekkestad Seghatchian, Jerard Hervig, Tor TI Symposium on fresh whole blood for severe hemorrhagic shock: From in-hospital to far forward resuscitations SO TRANSFUSION AND APHERESIS SCIENCE LA English DT Article DE Transfusion; Mortality; Survival; Combat; Whole blood; Hemorrhagic shock; Immunomodulation ID TRAUMA PATIENTS; APHERESIS PLATELETS; TRANSFUSION AB This report is prepared for The Hemostasis and Oxygenation Research (THOR) Network and based on presentations of invited THOR investigators. In order to make it available to a larger group of interested readers it has been agreed to publish the report in TRASCI, as a "what is happening?" in view of its importance and novelty. On June 14th 2011 the first symposium on fresh whole blood (FWB) was held in Bergen, Norway. THOR network leadership, which includes Tor Hervig, PhD, MD, Geir Strandenes, MD, Erling Bekkestad Rein, MD, and Philip C. Spinella, MD, organized the event. It was sponsored by the Royal Norwegian Navy Medical Service, Norwegian Armed Forces Medical Services and Caridian BCT. The objective of this meeting was to bring together investigators from around the world who are interested in analyzing the efficacy and safety of FWB for patients with severe traumatic hemorrhagic shock and to determine the initial steps in developing a, research program in this area. The THOR network is specifically interested in determining if FWB can improve morbidity and mortality in combat casualties with life threatening hemorrhagic shock. A three-year research proposal has been developed by the THOR network to determine (1) if FINB donation adversely affects donor performance of combat related skills, (2) the optimal storage solution, temperature, and acceptable storage duration for FWB, (3) the logistics of providing FWB in a combat environment safely to include optimal transport and administration methods. The symposium speakers were tasked with reviewing current data on; coagulopathy associated with massive traumatic bleeding, immunology of transfusion, outcomes associated with FWB use, logistic and medical issues of the use of FWB in far forward situations, training required for medics on FVVB collection and administration, the risks of FWB and stored blood components and methods to mitigate these risks. The meeting concluded with a discussion of the THOR network's three-year research program. Published by Elsevier Ltd. C1 [Spinella, Philip C.] Washington Univ, Div Crit Care, Dept Pediat, St Louis, MO 63110 USA. [Spinella, Philip C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Strandenes, Geir; Hervig, Tor] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway. [Rein, Erling Bekkestad] Univ Oslo, Inst Basic Med Sci, Oslo, Norway. [Seghatchian, Jerard] Blood Components Apheresis Technol & Thrombosi He, London, England. [Hervig, Tor] Univ Bergen, Gade Inst, N-5020 Bergen, Norway. RP Spinella, PC (reprint author), Washington Univ, Div Crit Care, Dept Pediat, 1 Childrens Pl,Campus Box 8116, St Louis, MO 63110 USA. EM spinella_p@kids.wustl.edu; jseghatchian@btopenworld.com NR 12 TC 15 Z9 17 U1 0 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1473-0502 J9 TRANSFUS APHER SCI JI Transfus. Apher. Sci. PD FEB PY 2012 VL 46 IS 1 BP 113 EP 117 DI 10.1016/j.transci.2012.01.002 PG 5 WC Hematology SC Hematology GA 912PN UT WOS:000301812200026 PM 22300839 ER PT J AU Schultz, S DeSilva, M Gu, TT Qiang, M Whang, K AF Schultz, Stephen DeSilva, Mauris Gu, Ting Ting Qiang, Mei Whang, Kyumin TI Effects of the Analgesic Acetaminophen (Paracetamol) and its para-Aminophenol Metabolite on Viability of Mouse-Cultured Cortical Neurons SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY LA English DT Article ID ENDOCANNABINOID SYSTEM; PHARMACOKINETICS; AUTISM; PLASMA AB Acetaminophen has been used as an analgesic for more than a hundred years, but its mechanism of action has remained elusive. Recently, it has been shown that acetaminophen produces analgesia by the activation of the brain endocannabinoid receptor CB1 through its para-aminophenol (p-aminophenol) metabolite. The objective of this study was to determine whether p-aminophenol could be toxic for in vitro developing mouse cortical neurons as a first step in establishing a link between acetaminophen use and neuronal apoptosis. We exposed developing mouse cortical neurons to various concentrations of drugs for 24 hr in vitro. Acetaminophen itself was not toxic to developing mouse cortical neurons at therapeutic concentrations of 10-250 mu g/ml. However, concentrations of p-aminophenol from 1 to 100 mu g/ml produced significant (p < 0.05) loss of mouse cortical neuron viability at 24 hr compared to the controls. The naturally occurring endocannabinoid anandamide also caused similar 24-hr loss of cell viability in developing mouse cortical neurons at concentrations from 1 to 100 mu g/ml, which indicates the mechanism of cell death could be through the cannabinoid receptors. The results of our experiments have shown a detrimental effect of the acetaminophen metabolite p-aminophenol on in vitro developing cortical neuron viability which could act through CB1 receptors of the endocannabinoid system. These results could be especially important in recommending an analgesic for children or individuals with traumatic brain injury who have developing cortical neurons. C1 [Schultz, Stephen; DeSilva, Mauris] USA, Med Res Unit San Antonio, Ft Sam Houston, TX 78234 USA. [Gu, Ting Ting; Qiang, Mei; Whang, Kyumin] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Schultz, S (reprint author), USA, Med Res Unit San Antonio, 3650 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM stephen.t.schultz@amedd.army.mil FU Naval Medical Research Unit San Antonio [G1008] FX This project was funded by work unit number G1008 from the Naval Medical Research Unit San Antonio. NR 18 TC 2 Z9 2 U1 1 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1742-7835 J9 BASIC CLIN PHARMACOL JI Basic Clin. Pharmacol. Toxicol. PD FEB PY 2012 VL 110 IS 2 BP 141 EP 144 DI 10.1111/j.1742-7843.2011.00767.x PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 907RD UT WOS:000301434200005 PM 21771276 ER PT J AU Pelin, M Sosa, S Della Loggia, R Poli, M Tubaro, A Decorti, G Florio, C AF Pelin, M. Sosa, S. Della Loggia, R. Poli, M. Tubaro, A. Decorti, G. Florio, C. TI The cytotoxic effect of palytoxin on Caco-2 cells hinders their use for in vitro absorption studies SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Palytoxin; Caco-2 cells; Cytotoxicity ID NEUROBLASTOMA-CELLS; LINE; IDENTIFICATION; NEURO-2A; BARRIER; OUABAIN; TOXINS; DEATH; MODEL AB Palytoxin (PLTX), found in Palythoa zoanthids and Ostreopsis dinoflagellates, has also been detected in crabs and fish, through which it can enter into the food chain. Indeed, PLTX is considered the causative agent of several cases of human seafood poisoning resulting in systemic symptoms. Available epidemiological data on PLTX human toxicity suggest that the intestinal tract may be one of its in vivo targets and its potential site of access into the bloodstream. Hence, the purpose of this study was to investigate the suitability of the human intestinal Caco-2 cell line for evaluating PLTX oral absorption. A detailed analysis of PLTX cytotoxicity revealed a high sensitivity of Caco-2 cells: 4 h toxin exposure reduced mitochondrial activity (MTT assay, EC50 of 8.9 +/- 3.7 x 10(-12) M), cell density (SRB assay, EC50 of 2.0 +/- 0.6 x 10(-11) M) and membrane integrity (LDH release, EC50 of 4.5 +/- 1.4 x 10(-9) M and PI uptake, EC50 of 1.0 +/- 0.8 x 10(-8) M). After low PLTX concentration (1.0 x 10(-11) M) exposure for 1-8 h, followed by 24 h recovery time in toxin-free medium, cell density reduction was only partially reversible. These results indicate that, due to the high susceptibility to PLTX cytotoxic effects, Caco-2 cells do not represent an appropriate and reliable model for investigating intestinal barrier permeation by this toxin. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Pelin, M.; Sosa, S.; Della Loggia, R.; Tubaro, A.; Decorti, G.; Florio, C.] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy. [Poli, M.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21701 USA. RP Decorti, G (reprint author), Univ Trieste, Dept Life Sci, Via L Giorgieri 7-9, I-34127 Trieste, Italy. EM marco.pelin@hotmail.it; SILVIO.SOSA@econ.units.it; ROBERTO.DELLALOGGIA@econ.units.it; mark.poli@us.army.mil; tubaro@units.it; decorti@units.it; florioc@units.it FU Italian Ministry of Education. University and Research (MIUR) FX This work was supported by a grant of the Italian Ministry of Education. University and Research (MIUR). NR 28 TC 14 Z9 14 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD FEB PY 2012 VL 50 IS 2 BP 206 EP 211 DI 10.1016/j.fct.2011.10.032 PG 6 WC Food Science & Technology; Toxicology SC Food Science & Technology; Toxicology GA 904SS UT WOS:000301218800017 PM 22019895 ER PT J AU Wilken, JM Rodriguez, KM Brawner, M Darter, BJ AF Wilken, Jason M. Rodriguez, Kelly M. Brawner, Melissa Darter, Benjamin J. TI Reliability and minimal detectible change values for gait kinematics and kinetics in healthy adults SO GAIT & POSTURE LA English DT Article DE Reliability; Minimal Detectable Change; Intraclass Correlation Coefficient; Gait analysis ID LIMB 3-DIMENSIONAL KINEMATICS; RETEST RELIABILITY; AMPUTEE GAIT; WALKING; REPEATABILITY; CHILDREN; PARAMETERS; SYSTEM; SPEED AB Computerized assessment of gait is commonly used in both research and clinical settings to quantify gait mechanics and detect change in performance. Minimal Detectable Change values have only recently been reported, are only available for patient populations, and in many cases exceed 10 degrees. Twenty nine healthy individuals underwent two biomechanical gait assessments separated by 5.6 (SD 2.2) days, with two raters for each session. All subjects walked at a self selected pace and three controlled velocities. ICC. SEM and MDC for kinematic and kinetic measures were calculated for interrater-intrasession, intrarater-intersession and interrater-intersession. ICC values were in the good to excellent range (r > 0.75) for all kinematic and kinetic variables and all comparisons. M DC values were lower than previously published data for all similar comparisons. The results of the current study suggest that reliability is good to excellent across a range of controlled walking velocities and the introduction of a second rater does not appreciably impact ICC or MDC values. In young healthy adults changes in gait kinematics of greater than approximately 50 can be identified when comparing between sessions. Published by Elsevier B.V. C1 [Wilken, Jason M.; Rodriguez, Kelly M.; Brawner, Melissa; Darter, Benjamin J.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. RP Wilken, JM (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. EM jason.wilken@us.army.mil OI Wilken, Jason/0000-0002-5556-7667 FU Military Amputee Research Program FX Support provided by the Military Amputee Research Program (to JMW). NR 32 TC 64 Z9 64 U1 0 U2 15 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0966-6362 J9 GAIT POSTURE JI Gait Posture PD FEB PY 2012 VL 35 IS 2 BP 301 EP 307 DI 10.1016/j.gaitpost.2011.09.105 PG 7 WC Neurosciences; Orthopedics; Sport Sciences SC Neurosciences & Neurology; Orthopedics; Sport Sciences GA 906BO UT WOS:000301320100024 PM 22041096 ER PT J AU Tian, Z Tafesse, Y Sadler, BM AF Tian, Zhi Tafesse, Yohannes Sadler, Brian M. TI Cyclic Feature Detection With Sub-Nyquist Sampling for Wideband Spectrum Sensing SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING LA English DT Article DE Cognitive radio (CR); compressive sampling; cyclic spectrum; feature detection; wideband spectrum sensing ID COGNITIVE RADIO; SIGNALS; CYCLOSTATIONARITY; NETWORKS; POWER AB For cognitive radio networks, efficient and robust spectrum sensing is a crucial enabling step for dynamic spectrum access. Cognitive radios need to not only rapidly identify spectrum opportunities over very wide bandwidth, but also make reliable decisions in noise-uncertain environments. Cyclic spectrum sensing techniques work well under noise uncertainty, but require high-rate sampling which is very costly in the wideband regime. This paper develops robust and compressive wideband spectrum sensing techniques by exploiting the unique sparsity property of the two-dimensional cyclic spectra of communications signals. To do so, a new compressed sensing framework is proposed for extracting useful second-order statistics of wideband random signals from digital samples taken at sub-Nyquist rates. The time-varying cross-correlation functions of these compressive samples are formulated to reveal the cyclic spectrum, which is then used to simultaneously detect multiple signal sources over the entire wide band. Because the proposed wideband cyclic spectrum estimator utilizes all the cross-correlation terms of compressive samples to extract second-order statistics, it is also able to recover the power spectra of stationary signals as a special case, permitting lossless rate compression even for non-sparse signals. Simulation results demonstrate the robustness of the proposed spectrum sensing algorithms against both sampling rate reduction and noise uncertainty in wireless networks. C1 [Tian, Zhi; Tafesse, Yohannes] Michigan Technol Univ, Dept Elect & Comp Engn, Houghton, MI 49931 USA. [Sadler, Brian M.] AMSRD ARL CI CN, Army Res Lab, Adelphi, MD 20783 USA. RP Tian, Z (reprint author), Michigan Technol Univ, Dept Elect & Comp Engn, Houghton, MI 49931 USA. EM ztian@mtu.edu; bsadler@arl.army.mil FU National Science Foundation [ECS-0925881, CNS-1017887] FX This work was supported in part by National Science Foundation Grants #ECS-0925881 and #CNS-1017887. A short version of this paper appeared in the IEEE International Conference on Communications (ICC), June 2011. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Octavia Dobre. NR 35 TC 83 Z9 90 U1 2 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1932-4553 J9 IEEE J-STSP JI IEEE J. Sel. Top. Signal Process. PD FEB PY 2012 VL 6 IS 1 BP 58 EP 69 DI 10.1109/JSTSP.2011.2181940 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA 908QJ UT WOS:000301504900005 ER PT J AU AbdulHameed, MDM Chaudhury, S Singh, N Sun, H Wallqvist, A Tawa, GJ AF AbdulHameed, Mohamed Diwan M. Chaudhury, Sidhartha Singh, Narender Sun, Hongmao Wallqvist, Anders Tawa, Gregory J. TI Exploring Polypharmacology Using a ROCS-Based Target Fishing Approach SO JOURNAL OF CHEMICAL INFORMATION AND MODELING LA English DT Article ID LIGAND-BASED APPROACH; LONG-QT-SYNDROME; DRUG DISCOVERY; PHARMACOLOGY; INHIBITORS; DOCKING; SERVER; SPACE; RATES; 2D AB Polypharmacology has emerged as a new theme in drug discovery. In this paper, we studied polypharmacology using a ligand-based target fishing (LBTF) protocol. To implement the protocol, we first generated a chemogenomic database that links individual protein targets with a specified set of drugs or target representatives. Target profiles were then generated for a given query molecule by computing maximal shape/chemistry overlap between the query molecule and the drug sets assigned to each protein target. The overlap was computed using the program ROCS (Rapid Overlay of Chemical Structures). We validated this approach using the Directory of Useful Decoys (DUD). DUD contains 2950 active compounds, each with 36 property-matched decoys, against 40 protein targets. We chose a set of known drugs to represent each DUD target, and we carried out ligand-based virtual screens using data sets of DUD actives seeded into DUD decoys for each target. We computed Receiver Operator Characteristic (ROC) curves and associated area under the curve (AUC) values. For the majority of targets studied, the AUC values were significantly better than for the case of a random selection of compounds. In a second test, the method successfully identified off-targets for drugs such as rimantadine, propranolol, and domperidone that were consistent with those identified by recent experiments. The results from our ROCS-based target fishing approach are promising and have potential application in drug repurposing for single and multiple targets, identifying targets for orphan compounds, and adverse effect prediction. C1 [AbdulHameed, Mohamed Diwan M.; Chaudhury, Sidhartha; Singh, Narender; Sun, Hongmao; Wallqvist, Anders; Tawa, Gregory J.] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP AbdulHameed, MDM (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM mabdulhameed@bioanalysis.org; gtawa@bioanalysis.org RI AbdulHameed, Mohamed Diwan M/O-3088-2015; OI AbdulHameed, Mohamed Diwan M/0000-0003-1483-4084; wallqvist, anders/0000-0002-9775-7469 NR 53 TC 34 Z9 35 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9596 J9 J CHEM INF MODEL JI J. Chem Inf. Model. PD FEB PY 2012 VL 52 IS 2 BP 492 EP 505 DI 10.1021/ci2003544 PG 14 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science, Information Systems; Computer Science, Interdisciplinary Applications SC Pharmacology & Pharmacy; Chemistry; Computer Science GA 897KU UT WOS:000300650400024 PM 22196353 ER PT J AU Killgore, WDS Capaldi, VF Guerrero, ML AF Killgore, William D. S. Capaldi, Vincent F., II Guerrero, Melanie L. TI NOCTURNAL POLYSOMNOGRAPHIC CORRELATES OF DAYTIME SLEEPINESS SO PSYCHOLOGICAL REPORTS LA English DT Article ID SLOW-WAVE SLEEP; WAKING COGNITIVE PERFORMANCE; SYNAPTIC HOMEOSTASIS; INSOMNIA COMPLAINTS; SODIUM OXYBATE; DEPRIVATION; ENHANCEMENT; PRESSURE; ADULTS; RESTRICTION AB The relations of nighttime polysomnographic sleep variables with daytime sleepiness scores on the Epworth Sleepiness Scale were assessed in a retrospective chart review of 38 patients referred to a sleep clinic. Of the variables assessed, only slow wave sleep was statistically significantly correlated with daytime sleepiness, regardless of whether the analysis was based on absolute minutes of slow wave sleep or percentage of total sleep time spent in slow wave sleep. Step-wise linear regression suggested that other polysomnographic variables did not provide additional predictive value beyond the two indices of slow wave sleep. Apparently, reduced quantity of slow wave sleep was weakly but significantly related to increased daytime sleepiness among these sleep-clinic patients. C1 [Killgore, William D. S.] Harvard Univ, Sch Med, Cambridge, MA 02138 USA. [Capaldi, Vincent F., II] Walter Reed Army Med Ctr, Silver Spring, MD USA. [Guerrero, Melanie L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Killgore, WDS (reprint author), Harvard Univ, Sch Med, Ctr Depress Anxiety & Stress Res, McLean Hosp, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 32 TC 0 Z9 0 U1 0 U2 0 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD FEB PY 2012 VL 110 IS 1 BP 63 EP 72 DI 10.2466/17.22.PR0.110.1.63-72 PG 10 WC Psychology, Multidisciplinary SC Psychology GA 909IY UT WOS:000301559400006 PM 22489378 ER PT J AU Ross, TM Bhardwaj, N Bissel, SJ Hartman, AL Smith, DR AF Ross, Ted M. Bhardwaj, Nitin Bissel, Stephanie J. Hartman, Amy L. Smith, Darci R. TI Animal models of Rift Valley fever virus infection SO VIRUS RESEARCH LA English DT Review DE Rift Valley fever virus; Mice; Sheep; Non-human primates; Review ID INBRED RAT STRAINS; ENZOOTIC HEPATITIS; SYRIAN-HAMSTERS; CULEX-PIPIENS; PUNTA-TORO; PATHOGENESIS; DISEASE; SHEEP; EFFICACY; VACCINE AB Emerging and naturally occurring infectious diseases from bacterial and viral sources are constantly threatening humans and livestock. Recently, a variety of infectious diseases have emerged into previously disease-free areas, resulting in new epidemics. Consequently, governmental agencies and researchers in the area of biomedical research have started designing ways to prevent their further spread. Ongoing research activities are focused on developing therapeutic and prophylactic interventions against these emerging infections. Development and evaluation of vaccines, diagnostics and treatments often depend on the development of appropriate animal models to determine the efficacy of new therapeutic agents. In addition, animal models are necessary to understand the basic pathobiology of infection. In this minireview, the current animal models used for one of these emerging infectious diseases, Rift Valley fever virus (RVFV), and the specifics of infection and pathology associated with each model are discussed. (C) 2011 Elsevier B.V. All rights reserved. C1 [Ross, Ted M.] Univ Pittsburgh, Sch Med, Ctr Vaccine Res, Pittsburgh, PA 15261 USA. [Ross, Ted M.; Bhardwaj, Nitin] Univ Pittsburgh, Dept Microbiol & Mol Genet, Pittsburgh, PA 15261 USA. [Bissel, Stephanie J.] Univ Pittsburgh, Dept Pathol, Div Neuropathol, Pittsburgh, PA 15261 USA. [Hartman, Amy L.] Univ Pittsburgh, Dept Infect Dis & Microbiol, Pittsburgh, PA 15261 USA. [Smith, Darci R.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Ross, TM (reprint author), Univ Pittsburgh, Sch Med, Ctr Vaccine Res, 9047 Biomed Sci Tower 3,3501 5th Ave, Pittsburgh, PA 15261 USA. EM tmr15@pitt.edu; darci.smith1@us.army.mil OI Hartman, Amy/0000-0002-0857-2973 FU NIH/NIAID [R01AI074946]; Pennsylvania Department of Health; Department of Defense through the Defense Threat Reduction Agency (DTRA) [HDTRA1-10-C-1066, TMT.DRUG.01.10.RD.002] FX This work was supported by an NIH/NIAID award R01AI074946 to TMR. This project was also funded, in part, under a grant with the Pennsylvania Department of Health. The Department specifically disclaims responsibility for any analyses, interpretations or conclusions. This work was supported in part by the Transformational Medical Technologies program contract HDTRA1-10-C-1066 to and contract TMT.DRUG.01.10.RD.002 to DRS from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA). NR 76 TC 16 Z9 16 U1 2 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD FEB PY 2012 VL 163 IS 2 BP 417 EP 423 DI 10.1016/j.virusres.2011.10.023 PG 7 WC Virology SC Virology GA 905XL UT WOS:000301309400001 PM 22086058 ER PT J AU Milojkovic, P Mait, JN AF Milojkovic, Predrag Mait, Joseph N. TI Space-bandwidth scaling for wide field-of-view imaging SO APPLIED OPTICS LA English DT Article ID INTERCONNECTIONS; DESIGN AB We examine the space-bandwidth product of wide field-of-view imaging systems as the systems scale in size. Our analysis is based on one conducted to examine the behavior of a plano-convex lens imaging onto a flat focal geometry. We extend this to consider systems with monocentric lenses and curved focal geometries. As a means to understand system cost, and not just performance, we also assess the volume and mass associated with these systems. Our analysis indicates monocentric lenses imaging onto a curved detector outperform other systems for the same design constraints but do so at a cost in lens weight. C1 [Milojkovic, Predrag; Mait, Joseph N.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mait, JN (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM joseph.mait@us.army.mil NR 14 TC 3 Z9 3 U1 1 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 2012 VL 51 IS 4 BP A36 EP A47 DI 10.1364/AO.51.000A36 PG 12 WC Optics SC Optics GA 894DY UT WOS:000300408400006 PM 22307128 ER PT J AU Bennett, G Catrysse, PB Farrell, JE Fowler, B Mait, JN AF Bennett, Gisele Catrysse, Peter B. Farrell, Joyce E. Fowler, Boyd Mait, Joseph N. TI Imaging systems and applications SO APPLIED OPTICS LA English DT Editorial Material AB Imaging systems are used in consumer, medical, and military applications. Designing, developing, and building imaging systems requires a multidisciplinary approach. This issue features current research in imaging systems that ranges from fundamental theories to novel applications. Although the papers collected are diverse, their unique compilation provides a systems perspective to imaging. (C) 2012 Optical Society of America C1 [Bennett, Gisele] Georgia Tech Res Inst, Electroopt Syst Lab, Atlanta, GA 30332 USA. [Catrysse, Peter B.] Stanford Univ, Edward L Ginzton Lab, Ctr Nanoscale Sci & Engn, Stanford, CA 94305 USA. [Farrell, Joyce E.] Stanford Univ, Ctr Image Syst Engn, Stanford, CA 94305 USA. [Fowler, Boyd] BAE Syst, Imaging Solut, Milpitas, CA 95035 USA. [Mait, Joseph N.] USA, Res Lab, RDRL SER, Adelphi, MD 20783 USA. RP Bennett, G (reprint author), Georgia Tech Res Inst, Electroopt Syst Lab, 925 Dalney St, Atlanta, GA 30332 USA. EM gisele.bennett@gtri.gatech.edu NR 0 TC 0 Z9 0 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 2012 VL 51 IS 4 BP ISA1 EP ISA1 DI 10.1364/AO.51.00ISA1 PG 1 WC Optics SC Optics GA 894DY UT WOS:000300408400001 PM 22307134 ER PT J AU West, BJ West, D AF West, B. J. West, D. TI Stochastic ontogenetic growth model SO EPL LA English DT Article ID ALLOMETRY; HISTORY; SIZE AB An ontogenetic growth model (OGM) for a thermodynamically closed system is generalized to satisfy both the first and second law of thermodynamics. The hypothesized stochastic ontogenetic growth model (SOGM) is shown to entail the interspecies allometry relation by explicitly averaging the basal metabolic rate and the total body mass over the steady-state probability density for the total body mass (TBM). This is the first derivation of the interspecies metabolic allometric relation from a dynamical model and the asymptotic steady-state distribution of the TBM is fit to data and shown to be inverse power law. Copyright (C) EPLA, 2012 C1 [West, B. J.] USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. [West, D.] Rensselaer Polytech Inst, Dept Phys, Troy, NY 12180 USA. RP West, BJ (reprint author), USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. EM bruce.j.west.civ@mail.mil RI West, Damien/F-8616-2012 OI West, Damien/0000-0002-4970-3968 NR 21 TC 4 Z9 4 U1 0 U2 4 PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY PI MULHOUSE PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE SN 0295-5075 J9 EPL-EUROPHYS LETT JI EPL PD FEB PY 2012 VL 97 IS 4 AR 48002 DI 10.1209/0295-5075/97/48002 PG 5 WC Physics, Multidisciplinary SC Physics GA 899VH UT WOS:000300844100037 ER PT J AU Sano, T Randow, CL AF Sano, Tomoko Randow, Charles L. TI Hierarchical Composite Materials: Achieving What a Single-Phase Material Cannot SO JOM LA English DT Editorial Material C1 [Sano, Tomoko; Randow, Charles L.] USA, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sano, T (reprint author), USA, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 4 TC 1 Z9 1 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 J9 JOM-US JI JOM PD FEB PY 2012 VL 64 IS 2 BP 212 EP 213 DI 10.1007/s11837-012-0248-x PG 2 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA 902LQ UT WOS:000301040000005 ER PT J AU Sohn, YH Patterson, T Hofmeister, C Kammerer, C Mohr, W Van Den Bergh, M Shaeffer, M Seaman, J Cho, K AF Sohn, Y. H. Patterson, T. Hofmeister, C. Kammerer, C. Mohr, W. Van Den Bergh, M. Shaeffer, M. Seaman, J. Cho, K. TI Tailoring Microstructure and Properties of Hierarchical Aluminum Metal Matrix Composites Through Friction Stir Processing SO JOM LA English DT Article ID NANOSTRUCTURED MATERIALS; STRENGTH; BEHAVIOR AB The fabrication of hierarchical aluminum metal matrix composites (MMCs) begins with the cryomilling of inert gas-atomized AA5083 Al powders with B4C particles, which yields agglomerates of nanocrystalline (NC) Al grains containing a uniform dispersion of solidly bonded, submicron B4C particles. The cryomilled agglomerates are size classified, blended with coarse-grain Al (CG-Al) powders, vacuum degassed at an elevated temperature, and consolidated to form the bulk composite. This hierarchical Al MMCs have low weight and high strength/stiffness attributable to the (A) Hall-Petch strengthening from NC-Al (5083) grains, (B) Zener pinning effects from B4C particulate reinforcement and dispersoids in both the NC-Al and CG-Al, (C) the interface characteristics between the three constituents, and (D) a high dislocation density. The hierarchical Al MMCs exhibit good thermal stability and microstructural characteristics that deflect or blunt crack propagation. A significant change in the microstructure of the composite was observed after friction stir processing (FSP) in the thermomechanically affected zone (TMAZ) due to the mechanical mixing, particularly in the advancing side of the stir zone (SZ). The NC-Al grains in the TMAZ grew during FSP. Evidence of CG-Al size reduction was also documented since CG-Al domain was absent by optical observation. Given the proper control of the microstructure, FSP has demonstrated its potential to increase both strength and ductility, and to create functionally tailored hierarchical MMCs through surface modification, graded structures, and other hybrid microstructural design. C1 [Sohn, Y. H.; Patterson, T.; Hofmeister, C.; Kammerer, C.] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. [Sohn, Y. H.; Patterson, T.; Hofmeister, C.; Kammerer, C.] Univ Cent Florida, Dept Mech Mat & Aerosp Engn, Orlando, FL 32816 USA. [Mohr, W.; Seaman, J.] Edison Welding Inst, Columbus, OH 43221 USA. [Van Den Bergh, M.] DWA Aluminum Composites, Chatsworth, CA 91311 USA. [Shaeffer, M.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Cho, K.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sohn, YH (reprint author), Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA. EM ysohn@mail.ucf.edu RI Sohn, Yongho/A-8517-2010 OI Sohn, Yongho/0000-0003-3723-4743 FU U.S. Army Research Laboratory FX Research was sponsored by U.S. Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-08-2-0026. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. Use of the Materials Characterization Facility at UCF is gratefully acknowledged. NR 10 TC 1 Z9 2 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 J9 JOM-US JI JOM PD FEB PY 2012 VL 64 IS 2 BP 234 EP 238 DI 10.1007/s11837-012-0249-9 PG 5 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA 902LQ UT WOS:000301040000008 ER PT J AU Bedrosian, PA Burton, BL Powers, MH Minsley, BJ Phillips, JD Hunter, LE AF Bedrosian, Paul A. Burton, Bethany L. Powers, Michael H. Minsley, Burke J. Phillips, Jeffrey D. Hunter, Lewis E. TI Geophysical investigations of geology and structure at the Martis Creek Dam, Truckee, California SO JOURNAL OF APPLIED GEOPHYSICS LA English DT Article DE Earthen dams; Martis Creek; Truckee Basin; ERT; Magnetotellurics; Seismic methods ID NORTHERN SIERRA-NEVADA; LAKE TAHOE; DEFORMATION; TOMOGRAPHY; INVERSION; LEAKAGE; AREA AB A recent evaluation of Martis Creek Dam highlighted the potential for dam failure due to either seepage or an earthquake on nearby faults. In 1972, the U.S. Army Corps of Engineers constructed this earthen dam, located within the Truckee Basin to the north of Lake Tahoe, CA for water storage and flood control. Past attempts to raise the level of the Martis Creek Reservoir to its design level have been aborted due to seepage at locations downstream, along the west dam abutment, and at the base of the spillway. In response to these concerns, the U.S. Geological Survey has undertaken a comprehensive suite of geophysical investigations aimed at understanding the interplay between geologic structure, seepage patterns, and reservoir and groundwater levels. This paper concerns the geologic structure surrounding Martis Creek Dam and emphasizes the importance of a regional-scale understanding to the interpretation of engineering-scale geophysical data. Our studies reveal a thick package of sedimentary deposits interbedded with Plio-Pleistocene volcanic flows: both the deposits and the flows are covered by glacial outwash. Magnetic field data, seismic tomography models, and seismic reflections are used to determine the distribution and chronology of the volcanic flows. Previous estimates of depth to basement (or the thickness of the interbedded deposits) was 100 m. Magnetotelluric soundings suggest that electrically resistive bedrock may be up to 2500 m deep. Both the Polaris Fault, identified outside of the study area using airborne LiDAR, and the previously unnamed Martis Creek Fault, have been mapped through the dam area using ground and airborne geophysics. Finally, as determined by direct-current resistivity imaging, time-domain electromagnetic sounding, and seismic refraction, the paleo-topography of the interface between the sedimentary deposits and the overlying glacial outwash plays a principal role both in controlling groundwater flow and in the distribution of the observed seepage. Published by Elsevier B.V. C1 [Bedrosian, Paul A.; Burton, Bethany L.; Powers, Michael H.; Minsley, Burke J.; Phillips, Jeffrey D.] US Geol Survey, Denver Fed Ctr, Denver, CO 80212 USA. [Hunter, Lewis E.] US Army Corps Engineers, Sacramento, CA USA. RP Bedrosian, PA (reprint author), US Geol Survey, Denver Fed Ctr, MS 964, Denver, CO 80212 USA. EM pbedrosian@usgs.gov OI Minsley, Burke/0000-0003-1689-1306 NR 42 TC 9 Z9 10 U1 1 U2 27 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-9851 J9 J APPL GEOPHYS JI J. Appl. Geophys. PD FEB PY 2012 VL 77 BP 7 EP 20 DI 10.1016/j.jappgeo.2011.11.002 PG 14 WC Geosciences, Multidisciplinary; Mining & Mineral Processing SC Geology; Mining & Mineral Processing GA 903CD UT WOS:000301092600002 ER PT J AU Cafasso, D Schneider, P AF Cafasso, D. Schneider, P. TI How paclitaxel can improve results in diabetics SO JOURNAL OF CARDIOVASCULAR SURGERY LA English DT Review DE Limb salvage; Peripheral arterial disease; drug-eluting stents; Angioplasty; Balloon dilation; Paclitaxel ID CRITICAL LIMB ISCHEMIA; DRUG-ELUTING STENTS; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PERIPHERAL ARTERIAL-DISEASE; SUPERFICIAL FEMORAL-ARTERY; SMALL CORONARY VESSELS; FEMOROPOPLITEAL ARTERIES; BALLOON ANGIOPLASTY; OCCLUSIVE DISEASE; VASCULAR-DISEASE AB Despite advances in endovascular techniques, the success of these revascularization procedures is limited by neointimal hyperplasia and subsequent restenosis or occlusion. Infrainguinal interventions have higher rates of restenosis after intervention in comparison to other vascular beds, and this is likely due to a host of anatomic, mechanical, biological and rheological factors that create a relatively hostile environment for the restoration of lower extremity perfusion through endovascular means. In addition, outcomes in the diabetic subpopulation are even worse, with a higher risk of amputation, re-interventions, and failed procedures in critical limb ischemia. Novel techniques for antiproliferative drug release into the vessel wall at the site of endovascular intervention have shown promising results in combating restenosis in the coronary arteries and data are accumulating to suggest promise in the infrainguinal arteries as well. The application of paclitaxel, delivered either through drug coated balloons or drug-eluting stents, has demonstrated benefit in enhanced durability of lower extremity endovascular procedures, and may be of particular advantage concerning diabetic limb salvage. This review presents an overview of the current literature and ongoing trials with the use of paclitaxel in diabetic lower extremity occlusive disease. C1 [Cafasso, D.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Schneider, P.] Hawaii Permanente Med Grp, Div Vasc Therapy, Honolulu, HI USA. [Schneider, P.] Kaiser Fdn Hosp, Honolulu, HI USA. RP Cafasso, D (reprint author), Tripler Army Med Ctr, Dept Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM danielle.cafasso@us.army.mil FU Terumo; Cordis; Medtronic; Cook FX interest. Dr. Schneider has participated as a consultant to Abbott Vascular, Medtronic, participated in research for Cordis, Abbott, and participated in educational programs supported by Terumo, Cordis, Medtronic, and Cook. NR 39 TC 4 Z9 4 U1 0 U2 2 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0021-9509 J9 J CARDIOVASC SURG JI J. Cardiovasc. Surg. PD FEB PY 2012 VL 53 IS 1 BP 13 EP 21 PG 9 WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Surgery GA 905KH UT WOS:000301270600003 PM 22231525 ER PT J AU Steele, CM van Lieshout, PHHM Pelletier, CA AF Steele, Catriona M. van Lieshout, Pascal H. H. M. Pelletier, Cathy A. TI The Influence of Stimulus Taste and Chemesthesis on Tongue Movement Timing in Swallowing SO JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH LA English DT Article DE tongue; swallowing; kinematics; electromagnetic articulography; aging; dysphagia ID GENETIC-VARIATION; NORMAL ADULTS; BOLUS VOLUME; SOUR BOLUS; PERCEPTION; APNEA; INDIVIDUALS; STIMULATION; CONSISTENCY; MODULATION AB Purpose: To explore the influence of taste and trigeminal irritation (chemesthesis) on durational aspects of tongue movement in liquid swallowing, controlling for the influence of perceived taste intensity. Method: Electromagnetic midsagittal articulography was used to trace tongue movements during discrete liquid swallowing with 5 liquids: water, 3 moderate concentration tastants without odor (sweet, sour, sweet-sour), and a high concentration of citric acid (sour taste plus chemesthesis). Participants were 33 healthy adults in 2 gender-balanced, age-stratified groups (under/over 50). Perceived taste intensity was measured using the Generalized Labeled Magnitude Scale (Bartoshuk, 2000; Bartoshuk et al., 2004). Tongue movement sequencing and durations of the composite tongue movement envelope and component events (rise phase, location of first movement peak, release phase) were calculated. Results: No obligate sequence of tongue segment movement was observed. Overall durations and the timing of the first movement peak were significantly longer with water than with the moderate concentration of sweet-sour liquid. Perceived taste intensity did not modulate stimulus effects in a significant way. The expected pattern of shorter movement durations with the high concentration of citric acid was not seen. Conclusions: A chemesthetic-taste stimulus of high citric acid did not influence the durations of tongue movements compared with those seen during the swallowing of moderate concentration tastants and water. C1 [Steele, Catriona M.; van Lieshout, Pascal H. H. M.] Toronto Rehabil Inst, Toronto, ON, Canada. [Steele, Catriona M.; van Lieshout, Pascal H. H. M.] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON, Canada. [Steele, Catriona M.] Holland Bloorview Kids Rehab, Toronto, ON, Canada. [van Lieshout, Pascal H. H. M.] Univ Toronto, Mississauga, ON L5L 1C6, Canada. [Pelletier, Cathy A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Steele, CM (reprint author), Toronto Rehabil Inst, Toronto, ON, Canada. EM steele.catriona@torontorehab.on.ca RI van Lieshout, Pascal/A-1371-2008; OI van Lieshout, Pascal/0000-0001-8139-8900; Steele, Catriona/0000-0002-4294-6561 FU Canadian Institutes of Health Research [644200, 69521, 83888] NR 39 TC 6 Z9 6 U1 0 U2 5 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1092-4388 J9 J SPEECH LANG HEAR R JI J. Speech Lang. Hear. Res. PD FEB 1 PY 2012 VL 55 IS 1 BP 262 EP 275 DI 10.1044/1092-4388(2011/11-0012) PG 14 WC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation SC Audiology & Speech-Language Pathology; Linguistics; Rehabilitation GA 903LE UT WOS:000301117200020 PM 22199186 ER PT J AU Clarisse, O Lotufo, GR Hintelmann, H Best, EPH AF Clarisse, O. Lotufo, G. R. Hintelmann, H. Best, E. P. H. TI Biomonitoring and assessment of monomethylmercury exposure in aqueous systems using the DGT technique SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE DGT; Dissolved methylmercury exposure; Clam; (Bio)-monitoring; Bioaccumulation; Bioavailability ID MACOMA-BALTHICA; TRANSPLANTED MUSSELS; DIFFUSIVE GRADIENTS; HUMIC SUBSTANCES; MYTILUS-EDULIS; TRACE-METAL; METHYLMERCURY; MERCURY; SPECIATION; WATER AB A series of laboratory experiments was conducted under realistic environmental conditions to test the ability of the Diffusive Gradient in Thin film (DGT) technique to mimic monomethylmercury (MMHg) bioaccumulation by a clam (Macoma balthica, Baltic clam). Using isotope enriched MMHg as tracers, bioavailability was determined by comparing the rate of MMHg uptake by novel DGT devices and sentinel organism over time. Experiments were conducted under varying conditions of salinity and MMHg speciation. Depending on MMHg level and speciation in the dissolved phase, MMHg uptake rates by the sentinel organism varied greatly from 0.4 to 2.4 L g(-1) d(-1). Reproducibilities of MMHg uptakes by DGT and clams were estimated at 7 and 38%, respectively. A significant linear relationship (log basis) between MMHg accumulation by DGT and clams was observed (r(2) = 0.89). The study demonstrates that DGT results reasonably predict MMHg uptake by clams from the aqueous phase and provide the basis for application of the DGT device as a surrogate for sentinel organism for monitoring bioavailable MMHg. (C) 2011 Elsevier B.V. All rights reserved. C1 [Clarisse, O.] Univ Moncton, Dept Chim & Biochim, Moncton, NB E1A 3EP, Canada. [Clarisse, O.; Hintelmann, H.] Trent Univ, Dept Chem, Peterborough, ON K9J 7B8, Canada. [Lotufo, G. R.; Best, E. P. H.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Best, E. P. H.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. RP Clarisse, O (reprint author), Univ Moncton, Dept Chim & Biochim, Moncton, NB E1A 3EP, Canada. EM olivier.clarisse@umoncton.ca OI Hintelmann, Holger/0000-0002-5287-483X FU Long-Term Management Strategy FX This research was supported by the Long-Term Management Strategy, administered by the US Army Corps of Engineers (USACE) San Francisco District, awarded for the project 'Comparison of accumulation of water- and sediment-associated mercury species in clams, fish, and DGT: DGT as a tool for environmental monitoring' to E.P.H.Best. NR 28 TC 9 Z9 10 U1 8 U2 71 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD FEB 1 PY 2012 VL 416 BP 449 EP 454 DI 10.1016/j.scitotenv.2011.11.077 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 903XE UT WOS:000301155200050 PM 22221872 ER PT J AU Kragh, JF Swan, KG Smith, DC Mabry, RL Blackbourne, LH AF Kragh, John F., Jr. Swan, Kenneth G. Smith, Dale C. Mabry, Robert L. Blackbourne, Lorne H. TI Historical review of emergency tourniquet use to stop bleeding SO AMERICAN JOURNAL OF SURGERY LA English DT Review DE Hemorrhage; First aid; Resuscitation; Extremity injury ID COMBAT CASUALTY CARE; MAJOR LIMB TRAUMA; HEMORRHAGE CONTROL; BATTLEFIELD; WOUNDS; ARMY; CONTROVERSY; EXPERIENCE; MORTALITY AB BACKGROUND: Although a common first aid topic, emergency tourniquets to stop bleeding are controversial because there is little experience on which to guide use. Absent an adequate historical analysis, we have researched development of emergency tourniquets from antiquity to the present. METHODS: We selected sources emphasizing historical development of tourniquets from books and databases such as PubMed. RESULTS: The history of the emergency tourniquet is long and disjointed, mainly written by hospital surgeons with little accounting, until recently, of the needs of forward medics near the point injury. Many investigators often are unaware of the breadth of the tourniquet's history and voice opinions based on anecdotal observations. CONCLUSIONS: Reporting the historical development of tourniquet use allowed us to recognize disparate problems investigators discuss but do not recognize, such as venous tourniquet use. We relate past observations with recent observations for use by subsequent investigators. Published by Elsevier Inc. C1 [Kragh, John F., Jr.] USA, Inst Surg Res, MCMR SRR R, Ft Sam Houston, TX 78234 USA. [Swan, Kenneth G.] Univ Med & Dent New Jersey, Dept Surg, Univ Hosp, Newark, NJ 07103 USA. [Smith, Dale C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Kragh, JF (reprint author), USA, Inst Surg Res, MCMR SRR R, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA. EM john.kragh1@us.army.mil NR 72 TC 13 Z9 14 U1 0 U2 3 PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC PI BRIDGEWATER PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD FEB PY 2012 VL 203 IS 2 BP 242 EP 252 DI 10.1016/j.amjsurg.2011.01.028 PG 11 WC Surgery SC Surgery GA 898VO UT WOS:000300770700019 PM 21782152 ER PT J AU Walton, TL Dean, RG Rosati, JD AF Walton, Todd L., Jr. Dean, Robert G. Rosati, Julie D. TI Sediment budget possibilities and improbabilities SO COASTAL ENGINEERING LA English DT Article DE Beach; Inlet; Linear algebra; Matrix algebra; Sand; Sediment bypassing; Sediment budget; Sediment management; Waves AB Problems of constructing a sediment budget for an inlet is often a challenge due to constraints on data collection, quality of data, and assumptions one is willing to consider. Existing literature does not provide a systematic foundation for equations considered and often engineers and geologists typically do not properly consider the mathematical constraints placed on the problem of sediment budget construction. The present technical note presents a simple methodology for assessing sediment budget, i.e. what is possible, and what is not possible via a matrix equation system and linear algebra. It is hoped that engineers and geologists will not impose unrealistic expectations on the sediment budget system via using such an approach. Some simple examples are given of both pitfalls and correct approaches to sediment budget development. (C) 2011 Elsevier B.V. All rights reserved. C1 [Walton, Todd L., Jr.] Florida State Univ, Beaches & Shores Res Ctr, Inst Sci & Publ Affairs, Tallahassee, FL 32310 USA. [Dean, Robert G.] Univ Florida, Civil & Coastal Engn Dept, Gainesville, FL USA. [Rosati, Julie D.] USA, Corps Engineers, Coastal Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Walton, TL (reprint author), Florida State Univ, Beaches & Shores Res Ctr, Inst Sci & Publ Affairs, 2035 E Paul Dirac Dr Morgan Bldg,Box 5, Tallahassee, FL 32310 USA. EM twalton@fsu.edu; dean@coastal.ufl.edu; julie.D.Rosati@usace.army.mil FU Florida Department of Environmental Protection-Bureau of Beaches and Coastal Systems FX The author would like to thank the Florida Department of Environmental Protection-Bureau of Beaches and Coastal Systems, Bureau Chief, Mike Barnett, and Coastal Engineering Chief, Bob Brantly, for their support and the opportunity to do research on inlets and beaches. NR 6 TC 1 Z9 1 U1 4 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD FEB PY 2012 VL 60 BP 323 EP 325 DI 10.1016/j.coastaleng.2011.08.008 PG 3 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 900WF UT WOS:000300921700026 ER PT J AU Dai, TH Vrahas, MS Murray, CK Hamblin, MR AF Dai, Tianhong Vrahas, Mark S. Murray, Clinton K. Hamblin, Michael R. TI Ultraviolet C irradiation: an alternative antimicrobial approach to localized infections? SO EXPERT REVIEW OF ANTI-INFECTIVE THERAPY LA English DT Review DE antibiotic resistance; bacteria; DNA repair; fungi; localized infections; mammalian cells; resistance to UVC; ultraviolet C irradiation; wound healing; wound infection ID HUMAN SKIN; ESCHERICHIA-COLI; IN-VIVO; 254 NM; LIGHT; RADIATION; DISINFECTION; INACTIVATION; PHOTOTHERAPY; EXPOSURE AB This review discusses the potential of ultraviolet C (UVC) irradiation as an alternative approach to current methods used to treat localized infections. It has been reported that multidrug-resistant microorganisms are equally sensitive to UVC irradiation as their wild-type counterparts. With appropriate doses, UVC may selectively inactivate microorganisms while preserving viability of mammalian cells and, moreover, is reported to promote wound healing. UVC is also found in animal studies to be less damaging to tissue than UVB. Even though UVC may produce DNA damage in mammalian cells, it can be rapidly repaired by DNA repair enzymes. If UVC irradiation is repeated excessively, resistance of microorganisms to UVC inactivation may develop. In summary, UVC should be investigated as an alternative approach to current methods used to treat localized infections, especially those caused by multidrug-resistant microorganisms. UVC should be used in a manner such that the side effects would be minimized and resistance of microorganisms to UVC would be avoided. C1 [Dai, Tianhong; Hamblin, Michael R.] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA. [Dai, Tianhong; Hamblin, Michael R.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA. [Vrahas, Mark S.] Massachusetts Gen Hosp, Dept Orthoped Surg, Boston, MA 02114 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Hamblin, Michael R.] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA. RP Hamblin, MR (reprint author), Massachusetts Gen Hosp, Wellman Ctr Photomed, 40 Blossom St, Boston, MA 02114 USA. EM hamblin@helix.mgh.harvard.edu OI Hamblin, Michael/0000-0001-6431-4605 FU Airlift Research Foundation [109421]; NIH [RO1AI050875] FX This study was supported in part by an Airlift Research Foundation Extremity Trauma Research Grant (grant #109421 to T Dai) and the NIH (grant RO1AI050875 to MRH). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. NR 48 TC 26 Z9 27 U1 1 U2 12 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1478-7210 J9 EXPERT REV ANTI-INFE JI Expert Rev. Anti-Infect. Ther. PD FEB PY 2012 VL 10 IS 2 BP 185 EP 195 DI 10.1586/ERI.11.166 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 900VN UT WOS:000300919700014 PM 22339192 ER PT J AU Sollanek, KJ Kenefick, RW Walsh, NP Fortes, MB Esmaeelpour, M Cheuvront, SN AF Sollanek, Kurt J. Kenefick, Robert W. Walsh, Neil P. Fortes, Matthew B. Esmaeelpour, Marieh Cheuvront, Samuel N. TI Assessment of thermal dehydration using the human eye: What is the potential? SO JOURNAL OF THERMAL BIOLOGY LA English DT Review DE Tear osmolarity; Tear break-up time; Intraocular pressure; Thermal dehydration; Sweat loss; Heat stress ID BREAK-UP TIME; PRECORNEAL TEAR FILM; HONG-KONG CHINESE; INDUCED OCULAR HYPOTENSION; IN-SITU KERATOMILEUSIS; INTRAOCULAR-PRESSURE; AQUEOUS-HUMOR; DRY EYE; TILT TEST; EXERCISE AB Human hydration assessment is a key component for the prevention and proper treatment of heat-related fluid and electrolyte imbalances within military, sports and clinical medicine communities. Despite the availability of many different methods for assessing hydration status, the need for a valid method or technology that is simple, rapid, non-invasive, universal (detects both hypertonic and isotonic hypovolaemia) and is applicable for static (single point in time) and dynamic (change across time) hydration assessment is widely acknowledged. The eye is one candidate body region that might afford such a measure given the intricate balance between ocular dynamics (tear and aqueous humor formation) and blood (plasma osmolality and volume), which is considered the criterion measure for hydration assessment. The aim of this review is to introduce and discuss the potential for using ocular measurements for non-invasive hydration assessment, including tear fluid osmolarity (Tosm), non-invasive tear break-up time (NITBUT) and intraocular pressure (IOP). There is a relevant physiological basis for testing the merit of ocular measures for human hydration assessment and recent data indicate that Tosm and IOP may have utility. Further investigations are warranted to determine the degree to which ocular measures can act as accurate and reliable non-invasive hydration status markers. Published by Elsevier Ltd. C1 [Sollanek, Kurt J.; Kenefick, Robert W.; Cheuvront, Samuel N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Walsh, Neil P.; Fortes, Matthew B.] Bangor Univ, Extremes Res Grp, Bangor, Gwynedd, Wales. [Esmaeelpour, Marieh] Rudolf Fdn Clin, Ludwig Boltzmann Inst Retinol & Biomicroscop Lase, Vienna, Austria. [Esmaeelpour, Marieh] Med Univ Vienna, Ctr Med Phys & Biomed Engn, Vienna, Austria. RP Cheuvront, SN (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM samuel.n.cheuvront@us.army.mil FU US Army Medical Research and Materiel Command FX We would like to sincerely thank Naresh Menon Ph.D. and Michael Sawka, Ph.D. for their consultation in preparation of this manuscript. Disclosures of potential conflicts of interest. The views, opinions and/or findings in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision unless so designated by other official designation. Disclosures of sources of funding supported by the US Army Medical Research and Materiel Command. NR 84 TC 6 Z9 6 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD FEB PY 2012 VL 37 IS 2 BP 111 EP 117 DI 10.1016/j.jtherbio.2011.12.006 PG 7 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA 900UX UT WOS:000300918000002 ER PT J AU Hawley, JS Weiner, WJ AF Hawley, Jason S. Weiner, William J. TI Hemiballismus: Current concepts and review SO PARKINSONISM & RELATED DISORDERS LA English DT Review DE Hemiballism; Hemichorea; Ballism; Subthalamic nucleus; Hyperkinetic movement disorders ID LONG-TERM PROGNOSIS; DEEP BRAIN-STIMULATION; SUBTHALAMIC NUCLEUS; HEMICHOREA-HEMIBALLISMUS; CORPUS LUYSII; INVOLUNTARY MOVEMENTS; BASAL GANGLIA; LESION; DISORDERS; BALLISMUS AB Hemiballism is a rare movement disorder characterized by a high amplitude movement of an entire limb or limbs on one side of the body. The acute development of hemiballismus is often caused by focal lesions in the contralateral basal ganglia and STN. Many etiologies exist for this rare disorder with vascular causes and nonketotic hyperglycemia being the most common. Clearer understanding of the pathophysiology of hemiballism has led to important insights into the function and interaction of structures within the basal ganglia. Newer models of basal ganglia function have been proposed based on the study of the pathophysiology of hemiballism. Prognosis is favorable for most patients with complete resolution with or without treatment. Medical and surgical treatments are often successful in reducing or completely ameliorating the movements in those patients with more severe movements. Published by Elsevier Ltd. C1 [Hawley, Jason S.] MAJ MC US Army, Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Weiner, William J.] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA. RP Hawley, JS (reprint author), MAJ MC US Army, Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM Jshawley1@yahoo.com NR 44 TC 10 Z9 12 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1353-8020 J9 PARKINSONISM RELAT D JI Parkinsonism Relat. Disord. PD FEB PY 2012 VL 18 IS 2 BP 125 EP 129 DI 10.1016/j.parkreldis.2011.08.015 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA 902CW UT WOS:000301017200003 PM 21930415 ER PT J AU Kolb, CM Ostrander, S Ramsey, MJ Burgos, RM Belnap, C AF Kolb, Caroline M. Ostrander, Scott Ramsey, Mitchell J. Burgos, Ricardo M. Belnap, Christina TI Pathology Quiz Case 1 Actinomycosis osteomyelitis of the temporal bone SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Editorial Material ID MALIGNANT EXTERNAL OTITIS; OXYGEN; BASE C1 [Kolb, Caroline M.; Ostrander, Scott; Ramsey, Mitchell J.; Burgos, Ricardo M.; Belnap, Christina] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kolb, CM (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD FEB PY 2012 VL 138 IS 2 BP 203 EP 205 PG 3 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 895VX UT WOS:000300525900017 PM 22351871 ER PT J AU Morrison, JJ Dubose, JJ Rasmussen, TE Midwinter, MJ AF Morrison, Jonathan J. Dubose, Joseph J. Rasmussen, Todd E. Midwinter, Mark J. TI Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study SO ARCHIVES OF SURGERY LA English DT Article ID PLACEBO-CONTROLLED TRIAL; CARDIAC-SURGERY; INJURY SEVERITY; TRANSFUSION; SCORE; PROPHYLAXIS; DEATH; WAR AB Objectives: To characterize contemporary use of tranexamic acid (TXA) in combat injury and to assess the effect of its administration on total blood product use, thromboembolic complications, and mortality. Design: Retrospective observational study comparing TXA administration with no TXA in patients receiving at least 1 unit of packed red blood cells. A subgroup of patients receiving massive transfusion (>= 10 units of packed red blood cells) was also examined. Univariate and multivariate regression analyses were used to identify parameters associated with survival. Kaplan-Meier life tables were used to report survival. Setting: A Role 3 Echelon surgical hospital in southern Afghanistan. Patients: A total of 896 consecutive admissions with combat injury, of which 293 received TXA, were identified from prospectively collected UK and US trauma registries. Main Outcome Measures: Mortality at 24 hours, 48 hours, and 30 days as well as the influence of TXA administration on postoperative coagulopathy and the rate of thromboembolic complications. Results: The TXA group had lower unadjusted mortality than the no-TXA group (17.4% vs 23.9%, respectively; P = .03) despite being more severely injured (mean [SD] Injury Severity Score, 25.2 [16.6] vs 22.5 [18.5], respectively; P < .001). This benefit was greatest in the group of patients who received massive transfusion (14.4% vs 28.1%, respectively; P = .004), where TXA was also independently associated with survival (odds ratio = 7.228; 95% CI, 3.016-17.322) and less coagulopathy (P = .003). Conclusions: The use of TXA with blood component-based resuscitation following combat injury results in improved measures of coagulopathy and survival, a benefit that is most prominent in patients requiring massive transfusion. Treatment with TXA should be implemented into clinical practice as part of a resuscitation strategy following severe wartime injury and hemorrhage. C1 [Rasmussen, Todd E.] USA, Inst Surg Res, USAF Med Corps, Ft Sam Houston, TX 78234 USA. [Dubose, Joseph J.; Rasmussen, Todd E.] USAF, Med Serv, Sci & Technol Sect, Lackland AFB, TX USA. [Morrison, Jonathan J.; Midwinter, Mark J.] New Queen Elizabeth Hosp, Natl Inst Hlth Res, Birmingham, W Midlands, England. [Morrison, Jonathan J.; Midwinter, Mark J.] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, USAF Med Corps, 3400 Rawley E Chambers Ave,Ste B, Ft Sam Houston, TX 78234 USA. EM todd.rasmussen@amedd.army.mil RI Midwinter, Mark/P-6264-2015 OI Midwinter, Mark/0000-0003-1836-7137 FU Office of the US Air Force Surgeon General; Air Force Medical Support Agency FX This work was supported by the Office of the US Air Force Surgeon General and was created in the performance of a contract with the Air Force Medical Support Agency. NR 27 TC 193 Z9 196 U1 1 U2 20 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD FEB PY 2012 VL 147 IS 2 BP 113 EP 119 DI 10.1001/archsurg.2011.287 PG 7 WC Surgery SC Surgery GA 895VJ UT WOS:000300524500005 PM 22006852 ER PT J AU Kogot, JM Sarkes, DA Val-Addo, I Pellegrino, PM Stratis-Cullum, DN AF Kogot, Joshua M. Sarkes, Deborah A. Val-Addo, Irene Pellegrino, Paul M. Stratis-Cullum, Dimitra N. TI Increased affinity and solubility of peptides used for direct peptide ELISA on polystyrene surfaces through fusion with a polystyrene-binding peptide tag SO BIOTECHNIQUES LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; CIRCULAR-DICHROISM SPECTRA; CELL-SURFACE; BACTERIAL DISPLAY; PROTEIN; EXPRESSION; ANTIBODIES; LIBRARIES; PHAGE; IMMOBILIZATION AB Peptide reagents can serve as alternatives or replacements to antibodies in sensing or diagnostic applications. The passive adsorption of peptides onto polystyrene surfaces can limit the target binding capability, especially for short, positively charged, or hydrophobic sequences. In this report, we show that fusing a peptide with a previously characterized 12-amino acid polystyrene binding sequence (PS-tag) improves overall peptide solubility and enzyme-linked immunosorbent assay (ELISA) results using the peptide as a capture agent. Specific improvements for protective antigen (PA; Bacillus anthracis) protein binding peptides selected from bacterial surface display were compared with native or biotinylated peptides. The PS-tag was added to either peptide terminus, using a (Gly)(4) spacer, and comparable binding affinities were obtained. Fusion with the PS-tag did not have any negative impact on peptide secondary structure as measured by circular dichroism. The addition of the PS-tag provides a convenient method to utilize peptide reagents from peptide display libraries as capture agents in an ELISA format without the need for a biotin tag or concerns about passive adsorption of critical residues for target capture. C1 [Kogot, Joshua M.; Sarkes, Deborah A.; Val-Addo, Irene; Pellegrino, Paul M.; Stratis-Cullum, Dimitra N.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Kogot, JM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM joshua.m.kogot.civ@mail.mil RI Stratis-Cullum, Dimitra/F-9363-2013 OI Stratis-Cullum, Dimitra/0000-0002-4832-6945 FU Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense [BRCALL08-Per3-P-2-0028] FX The work was supported in part by support from the Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense (grant no. BRCALL08-Per3-P-2-0028). NR 44 TC 9 Z9 9 U1 0 U2 20 PU BIOTECHNIQUES OFFICE PI NEW YORK PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA SN 0736-6205 EI 1940-9818 J9 BIOTECHNIQUES JI Biotechniques PD FEB PY 2012 VL 52 IS 2 BP 95 EP + DI 10.2144/000113810 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 895CE UT WOS:000300473000007 PM 22313407 ER PT J AU Manalai, P Hamilton, RG Langenberg, P Kosisky, SE Lapidus, M Sleemi, A Scrandis, D Cabassa, JA Rogers, CA Regenold, WT Dickerson, F Vittone, BJ Guzman, A Balis, T Tonelli, LH Postolache, TT AF Manalai, Partam Hamilton, Robert G. Langenberg, Patricia Kosisky, Susan E. Lapidus, Manana Sleemi, Aamar Scrandis, Debra Cabassa, Johanna A. Rogers, Christine A. Regenold, William T. Dickerson, Faith Vittone, Bernard J. Guzman, Alvaro Balis, Theodora Tonelli, Leonardo H. Postolache, Teodor T. TI Pollen-specific immunoglobulin E positivity is associated with worsening of depression scores in bipolar disorder patients during high pollen season SO BIPOLAR DISORDERS LA English DT Article DE allergen; allergen-specific IgE antibody; allergy; bipolar disorder; depression; ragweed pollen; tree pollen ID 1966 BIRTH COHORT; NUTRITION EXAMINATION SURVEY; ALLERGIC RHINITIS; ATYPICAL DEPRESSION; MAJOR DEPRESSION; CYTOKINE EXPRESSION; SUICIDE COMPLETION; ATOPIC DISORDERS; NATIONAL-HEALTH; IMMUNE-SYSTEM AB Objective: An association between allergic disease and depression has been consistently reported, but whether the key mediating ingredients are predominantly biological, psychological, or mere artifacts remains unknown. In the current study, we examined a hypothesized relationship between allergen-specific immunoglobulin E (IgE) status and changes in allergy symptoms with worsening in depression scores. Methods: In patients with recurrent mood disorders, we individually coupled sensitization to specific seasonal aeroallergens (as assessed by allergen-specific IgE) with temporal windows of exposure to aeroallergens (low versus high tree or ragweed pollen counts, measured according to the National Allergy Bureau guidelines). We compared Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version (SIGH-SAD) depression score changes in 41 patients with mood disorders [25 with major depression and 16 with bipolar I disorder, diagnosed by Structured Clinical Interview for DSM (SCID)] seropositive for tree or ragweed pollen-specific IgE antibody versus 53 patients with mood disorders (30 with major depression and 23 with bipolar I disorder) seronegative for aeroallergen-specific IgE. Results: Worsening in total depressive scores from low to high pollen exposure was greater in allergen-specific IgE-positive patients as compared to allergen-specific IgE antibody-negative patients (p = 0.01). When stratified by polarity, the association was significant only in patients with bipolar I disorder (p = 0.004). This relationship was resilient to adjustment for changes in allergy symptom scores. Conclusion: To our knowledge, this is the first report of coupling a molecular marker of vulnerability (allergen-specific IgE) with a specific environmental trigger (airborne allergens) leading to exacerbation of depression in patients with bipolar I disorder. C1 [Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA. [Manalai, Partam; Postolache, Teodor T.] St Elizabeth Hosp, Residency Training Program, Washington, DC USA. [Vittone, Bernard J.; Guzman, Alvaro; Postolache, Teodor T.] Natl Ctr Treatment Phobias Anxiety & Depress, Washington, DC USA. [Hamilton, Robert G.] Johns Hopkins Univ, Sch Med, Dept Med, Allergy & Clin Immunol Div, Baltimore, MD 21218 USA. [Kosisky, Susan E.] USA, Centralized Allergen Extract Lab, Dept Allergy & Immunol, Walter Reed Army Med Ctr, Washington, DC 20310 USA. [Rogers, Christine A.] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Publ Hlth, Amherst, MA 01003 USA. [Regenold, William T.] Univ Maryland, Dept Psychiat, Adult Psychiat Inpatient Unit, Baltimore, MD 21201 USA. [Dickerson, Faith] Sheppard Pratt Hlth Syst, Stanley Res Ctr, Baltimore, MD USA. RP Postolache, TT (reprint author), Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, 685 W Baltimore St,MSTF Bldg,Room 930, Baltimore, MD 21201 USA. EM tpostolache@psych.umaryland.edu RI Rogers, Christine/A-2189-2008 OI Rogers, Christine/0000-0003-0887-9606 FU National Institute of Mental Health [R21 MH075891-01A1]; Johns Hopkins University Dermatology, Allergy, and Clinical Immunology (DACI) Reference Laboratory; University of Maryland General Clinical Research Center [M01 RR 16500]; General Clinical Research Centers, National Center for Research Resources (NCRR), NIH; American Foundation for Suicide Prevention [R01MH074891]; NARSAD FX This study was supported by grant R21 MH075891-01A1 from the National Institute of Mental Health (TTP: Principal Investigator) and by research funds from the Johns Hopkins University Dermatology, Allergy, and Clinical Immunology (DACI) Reference Laboratory (RGH: Principal Investigator). The execution of this study was also supported by the University of Maryland General Clinical Research Center Grant M01 RR 16500, General Clinical Research Centers Program, National Center for Research Resources (NCRR), NIH. TTP was additionally supported by R01MH074891, a grant from the American Foundation for Suicide Prevention, and a NARSAD Independent Investigator Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health. NR 58 TC 12 Z9 13 U1 1 U2 13 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1398-5647 J9 BIPOLAR DISORD JI Bipolar Disord. PD FEB PY 2012 VL 14 IS 1 BP 90 EP 98 DI 10.1111/j.1399-5618.2012.00983.x PG 9 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 894SU UT WOS:000300448000010 PM 22329476 ER PT J AU White, AB Colman, B Carter, GM Ralph, FM Webb, RS Brandon, DG King, CW Neiman, PJ Gottas, DJ Jankov, I Brill, KF Zhu, YJ Cook, K Buehner, HE Opitz, H Reynolds, DW Schick, LJ AF White, Allen B. Colman, Brad Carter, Gary M. Ralph, F. Martin Webb, Robert S. Brandon, David G. King, Clark W. Neiman, Paul J. Gottas, Daniel J. Jankov, Isidora Brill, Keith F. Zhu, Yuejian Cook, Kirby Buehner, Henry E. Opitz, Harold Reynolds, David W. Schick, Lawrence J. TI NOAA'S RAPID RESPONSE TO THE HOWARD A. HANSON DAM FLOOD RISK MANAGEMENT CRISIS SO BULLETIN OF THE AMERICAN METEOROLOGICAL SOCIETY LA English DT Article ID ATMOSPHERIC RIVERS; PRECIPITATION FORECASTS; NORTHERN CALIFORNIA; VERTICAL STRUCTURE; PACIFIC-NORTHWEST; RADAR; ENSEMBLE; CALJET; RAIN; LEVEL C1 [White, Allen B.; Ralph, F. Martin; Webb, Robert S.; King, Clark W.; Neiman, Paul J.; Gottas, Daniel J.] NOAA, Earth Syst Res Lab, Div Phys Sci, Boulder, CO 80305 USA. [Colman, Brad; Cook, Kirby; Buehner, Henry E.] NOAA, Natl Weather Serv, WFO Seattle, Seattle, WA USA. [Carter, Gary M.] NOAA, Natl Weather Serv, Off Hydrol Dev, Silver Spring, MD 20910 USA. [Brandon, David G.] NOAA, Natl Weather Serv, Western Reg Hydrol Serv, Salt Lake City, UT USA. [Brandon, David G.] NOAA, Natl Weather Serv, Climate Serv, Salt Lake City, UT USA. [Jankov, Isidora] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Jankov, Isidora] NOAA, Earth Syst Res Lab, Global Syst Div, Boulder, CO 80305 USA. [Brill, Keith F.] NOAA, Natl Weather Serv, Hydrometeorol Predict Ctr, Suitland, MD USA. [Zhu, Yuejian] NOAA, NWS, Natl Ctr Environm Predict, Environm Modeling Ctr, Camp Springs, MD USA. [Opitz, Harold] NOAA, Natl Weather Serv, Pacific NW RFC, Portland, OR USA. [Reynolds, David W.] NOAA, Natl Weather Serv, WFO San Francisco Bay Area, Monterey, CA USA. [Schick, Lawrence J.] USA, Corps Engineers, Seattle, WA USA. RP White, AB (reprint author), NOAA, Earth Syst Res Lab R PS2, 325 Broadway, Boulder, CO 80305 USA. EM allen.b.white@noaa.gov RI jankov, isidora/D-2830-2015 FU NWS Office of Science and Technology; NWS Office of Hydrologic Development; Office of Oceanic and Atmospheric Research; NOAA/ESRL Physical Sciences Division FX This study would not have been possible without the dedicated support of the talented engineering and technical team located in the Physical Sciences Division of NOAA's Earth System Research Laboratory, which built, deployed, and maintained the radars used in this study. In particular, we acknowledge Mr. James R. Jordan and Dr. Clark W. King for managing the staff and field deployments. We thank the city of Westport for providing a site for the ARO at Westport and Pierce County and the city of Tacoma/Tacoma Water Agency for providing sites for the equipment in the ARO couplet at Spanaway and Ravensdale, respectively. This work was supported by grants from the NWS Office of Science and Technology, the NWS Office of Hydrologic Development, the Office of Oceanic and Atmospheric Research, and the NOAA/ESRL Physical Sciences Division. NR 52 TC 14 Z9 14 U1 2 U2 7 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0003-0007 EI 1520-0477 J9 B AM METEOROL SOC JI Bull. Amer. Meteorol. Soc. PD FEB PY 2012 VL 93 IS 2 BP 189 EP 207 DI 10.1175/BAMS-D-11-00103.1 PG 19 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 897FP UT WOS:000300632200007 ER PT J AU Edwards, CE Parchman, TL Weekley, CW AF Edwards, Christine E. Parchman, Thomas L. Weekley, Carl W. TI Assembly, Gene Annotation and Marker Development Using 454 Floral Transcriptome Sequences in Ziziphus Celata (Rhamnaceae), a Highly Endangered, Florida Endemic Plant SO DNA RESEARCH LA English DT Article DE transcriptome; conservation genetics; microsatellites; S-locus; Ziziphus ID LAKE-WALES RIDGE; REPRODUCTIVE-BIOLOGY; SELF-INCOMPATIBILITY; CONSERVATION GENETICS; DISCOVERY; POPULATION; GENERATION; SHRUB; POLLINATION; TECHNOLOGY AB Large-scale DNA sequence data may enable development of genetic resources in endangered species, thereby facilitating conservation efforts. Ziziphus celata, a federally endangered, self-incompatible plant species occurring in Florida, USA, is one species for which genetic resources are necessary to facilitate new introductions and augmentations essential for recovery of the species. We used 454 pyrosequencing of a Z. celata normalized floral cDNA library to create a genomic resource for gene and marker discovery. A half-plate GS-FLX Titanium run yielded 655 337 reads averaging 250 bp. A total of 474 025 reads were assembled de novo into 84 645 contigs averaging 408 bp, while 181 312 reads remained unassembled. Forty-seven and 43% of contig consensus sequences had BLAST matches to known proteins in the Uniref50 and TAIR9 annotated protein databases, respectively; many contigs fully represented orthologous proteins in TAIR9. A total of 22 707 unique genes were sequenced, indicating substantial coverage of the Z. celata transcriptome. We detected single-nucleotide polymorphisms and simple sequence repeats (SSRs) and developed thousands of SSR primers for use in future genetic studies. As a first step towards understanding self-incompatibility in Z. celata, we identified sequences belonging to the gene family encoding self-incompatibility. This study demonstrates the efficacy of 454 transcriptome sequencing for rapid gene and marker discovery in an endangered plant. C1 [Edwards, Christine E.] USACE ERDC, Environm Lab, Vicksburg, MS 39180 USA. [Parchman, Thomas L.] Univ Wyoming, Dept Bot, Laramie, WY 82071 USA. [Weekley, Carl W.] Archbold Biol Stn, Lake Placid, FL 33862 USA. RP Edwards, CE (reprint author), USACE ERDC, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM christine.e.edwards@usace.army.mil; tparchma@uwyo.edu OI Edwards, Christine/0000-0001-8837-4872 FU US Fish and Wildlife Service [40181AG003]; Florida Division of Forestry Plant Conservation; Archbold Biological Station FX This work was supported by the US Fish and Wildlife Service (Grant #40181AG003 to C.W.W.), the Florida Division of Forestry Plant Conservation Grants Program, and Archbold Biological Station. NR 48 TC 26 Z9 26 U1 0 U2 21 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1340-2838 J9 DNA RES JI DNA Res. PD FEB PY 2012 VL 19 IS 1 BP 1 EP 9 DI 10.1093/dnares/dsr037 PG 9 WC Genetics & Heredity SC Genetics & Heredity GA 898RR UT WOS:000300760000001 PM 22039173 ER PT J AU Casem, DT Grunschel, SE Schuster, BE AF Casem, D. T. Grunschel, S. E. Schuster, B. E. TI Normal and Transverse Displacement Interferometers Applied to Small Diameter Kolsky Bars SO EXPERIMENTAL MECHANICS LA English DT Article DE Kolsky bar; Split Hopkinson Pressure Bar; Normal displacement interferometer; Transverse displacement interferometer; High strain-rate testing ID HOPKINSON PRESSURE BAR; HIGH-STRAIN RATES; DISPERSION; IMPACT AB For Kolsky bar testing beyond strain-rates of 10,000/s, it is useful to employ bars with diameters of only a few millimeters or less. Furthermore, very small (sub-millimeter) systems are compatible with micron-sized specimens, to be used, for example, for the determination of mesoscale properties. However, at these sizes, traditional strain-gage measurements of the longitudinal waves within the bars become impractical. In this paper we describe the application of optical measurement techniques to two Kolsky bars, with 3.2 and 1.6 mm diameters. A transverse displacement interferometer is used to measure the displacement of the mid-point of the incident bar and provide measurements of the incident and reflected pulses. Similarly, a normal displacement interferometer is used to measure the displacement of the free-end of the transmitter bar and provide a measurement of the transmitted pulse. The new methods are used to characterize the behavior of 6061-T6 aluminum at rates greater than 100,000/s. The feasibility of application to smaller bars is also discussed. C1 [Casem, D. T.] USA, Res Lab, RDRL WMP B, Aberdeen, MD 21005 USA. [Schuster, B. E.] USA, Res Lab, RDRL WML H, Aberdeen, MD 21005 USA. [Grunschel, S. E.] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. RP Casem, DT (reprint author), USA, Res Lab, RDRL WMP B, Aberdeen, MD 21005 USA. EM Daniel.t.casem.civ@mail.mil FU U.S. Army Research Laboratory; U.S. Department of Energy; USARL FX This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USARL. NR 21 TC 8 Z9 8 U1 1 U2 13 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0014-4851 EI 1741-2765 J9 EXP MECH JI Exp. Mech. PD FEB PY 2012 VL 52 IS 2 SI SI BP 173 EP 184 DI 10.1007/s11340-011-9524-x PG 12 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA 896PS UT WOS:000300582300007 ER PT J AU Urso, ML Wang, RB Zambraski, EJ Liang, BT AF Urso, Maria L. Wang, Ruibo Zambraski, Edward J. Liang, Bruce T. TI Adenosine A(3) receptor stimulation reduces muscle injury following physical trauma and is associated with alterations in the MMP/TIMP response SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE matrix metalloprotease; tissue inhibitors of metalloproteases ID 1-MATRIX METALLOPROTEINASE MT1-MMP; PULPOSUS TISSUE DEGENERATION; STRETCH-INDUCED ACTIVATION; RAT SKELETAL-MUSCLE; MOUSE SOLEUS MUSCLE; K-ATP CHANNEL; MATRIX METALLOPROTEINASES; CELL-SURFACE; TNF-ALPHA; IN-VITRO AB Urso ML, Wang R, Zambraski EJ, Liang BT. Adenosine A(3) receptor stimulation reduces muscle injury following physical trauma and is associated with alterations in the MMP/TIMP response. J Appl Physiol 112: 658-670, 2012. First published November 23, 2011; doi: 10.1152/japplphysiol.00809.2011.-We have previously demonstrated that in response to traumatic injury in skeletal muscle, there is a dysregulation of the matrix metalloproteases (MMPs) and their inhibitors (TIMPs), a response hypothesized to interfere with proper skeletal muscle regeneration. Moreover, we have shown that pharmacological activation of the adenosine A(3) receptor by Cl-IBMECA in skeletal muscle can protect against ischemia-reperfusion and eccentric exercise injury. However, the mechanism by which Cl-IBMECA protects muscle tissue is poorly defined. This study evaluated the effects of Cl-IBMECA on MMP/TIMP expression in skeletal muscle and tested the hypothesis that adenosine A(3) receptor-stimulated protection of skeletal muscle following traumatic injury is associated with a blunting of MMPs involved in inflammatory processes and collagen degradation, and an increase in MMPs associated with extracellular matrix remodeling. Sixty C57BL/6J male mice were injected with Cl-IBMECA (n = 30) or a vehicle (n = 30), and Evans blue dye. Injury was induced by applying a cold steel probe (-79 degrees C) to the tibialis anterior (TA) muscle for 10 s. TA muscles from uninjured and injured legs were collected 3, 10, and 24 h postinjury for analysis of muscle injury and MMP/TIMP mRNA and protein levels. Twenty-four hours postinjury, 56.8% of the fibers were damaged in vehicle-treated mice vs. 35.4% in Cl-IBMECA-treated mice (P = 0.02). Cl-IBMECA treatment reduced membrane type 1 (MT1)-MMP, MMP-3, MMP-9, and TIMP-1 mRNA expression 2- to 20-fold compared with vehicle-treated mice (P < 0.05). Cl-IBMECA decreased protein levels of latent/shed MT1-MMP 23-2,000%, respectively, 3-10 h postinjury. In Cl-IBMECA-treated mice, latent MMP-2 was decreased 20% 3 h postinjury, active MMP-3 was decreased 64% 3 h postinjury, and latent/active MMP-9 was decreased 417,631% 3 h postinjury and 20% 10 h postinjury. Protein levels of active MMP-2 and latent MMP-3 were increased 25% and 74% 3 h postinjury, respectively. The present study elucidates a new protective role of adenosine A(3) receptor stimulation in posttraumatic skeletal muscle injury. C1 [Urso, Maria L.; Zambraski, Edward J.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Wang, Ruibo; Liang, Bruce T.] Univ Connecticut, Pat & Jim Calhoun Cardiol Ctr, Ctr Hlth, Farmington, CT USA. RP Urso, ML (reprint author), USA, Environm Med Res Inst, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM maria.urso@us.army.mil OI Urso, Maria/0000-0001-8906-4673 NR 59 TC 7 Z9 8 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD FEB PY 2012 VL 112 IS 4 BP 658 EP 670 DI 10.1152/japplphysiol.00809.2011 PG 13 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 897CB UT WOS:000300617700016 PM 22114177 ER PT J AU Kern, SQ McMann, LP AF Kern, Sean Q. McMann, Leah P. TI Bilateral fibrous pseudotumors of the tunica albuginea in a pediatric patient SO JOURNAL OF PEDIATRIC UROLOGY LA English DT Article DE Fibrinous pseudotumor; Nodular periorchitis; Tunica albuginea; Pediatric ID TUMOR AB Fibrous pseudotumor, previously named nodular fibrous periorchitis, is a very rare disease entity in the pediatric patient. This is the first reported case of bilateral synchronous fibrous pseudotumors in the testes of a pediatric patient. Published by Elsevier Ltd on behalf of Journal of Pediatric Urology Company. C1 [Kern, Sean Q.; McMann, Leah P.] Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. RP Kern, SQ (reprint author), Tripler Army Med Ctr, Dept Surg, Urol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM sean.kern@amedd.army.mil NR 6 TC 3 Z9 4 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1477-5131 J9 J PEDIATR UROL JI J. Pediatr. Urol PD FEB PY 2012 VL 8 IS 1 BP E1 EP E3 DI 10.1016/j.jpurol.2011.10.003 PG 3 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA 894TW UT WOS:000300450800001 PM 22023845 ER PT J AU Drake, GW Bolden, S Dailey, J McQuaid, MJ Parrish, D AF Drake, Gregory W. Bolden, Sarah Dailey, Jami McQuaid, Michael J. Parrish, Damon TI New Takes on Nitrate Ester Chemistry: Salts with Oxygen-Rich Ammonium Cations SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Nitroxy salts; Gibbs free energy calculations ID SET MODEL CHEMISTRY; ENERGETIC SALTS; IONIC LIQUIDS; PENTAERYTHRITOL TETRANITRATE; THERMAL-DECOMPOSITION; ORGANIC NITRATES; METHYL NITRATE; TOTAL ENERGIES; DENSITY; HEATS AB Nitrate (anion) salts with nitroxy-functionalized ammonium cations were synthesized. Several revealed surprising thermal and hydrolytic stability. Various physical properties were measured, and Gibbs free energy (?Gr(298)) differences between the salts and postulated products of their thermal decomposition were computed. The computed differences indicate that salts with cations that have more than one nitroxy group are endothermic at 298 K. Nevertheless, the stability observed for some salts with this property indicates that kinetic barriers are sufficient to prevent facile decomposition at this temperature. This is in contrast to the case observed for nitrate salts of nitroxy-functionalized ammonium cations with acidic protons. C1 [Drake, Gregory W.; Bolden, Sarah; Dailey, Jami] USA, Aviat & Missile Res Dev & Engn Ctr RDMR WDP E, Redstone Arsenal, AL 35898 USA. [Dailey, Jami] ERC Inc, Weap Directorate, Redstone Arsenal, AL 35898 USA. [McQuaid, Michael J.] USA, Res Lab, RDRL WMD D, Aberdeen Proving Ground, MD 21005 USA. [Parrish, Damon] USN, Res Lab, Washington, DC 20375 USA. RP Drake, GW (reprint author), USA, Aviat & Missile Res Dev & Engn Ctr RDMR WDP E, Bldg 7120 Redstone Rd, Redstone Arsenal, AL 35898 USA. EM Gregory.w.drake@us.army.mil FU SERDP [WP-1764]; EQBRD; AMRDEC FX Funding for this study was provided under SERDP project WP-1764 (administered by Mr. J. Hough) and an EQBRD program (administered by Mr. M. Wrazen and Ms. Kristin Dawag, both of the U.S. Army ARDEC, Picatinny Arsenal, NJ). Most of the computations were conducted with CPU time provided under the High Performance Computing and Modernization Office Challenge project C4C, and were performed at the Air Force Research Laboratory DoD Supercomputing Resource Center, Wright-Patterson Air Force Base, OH. AMRDEC researchers are grateful to Mr. Michael Morrison, Dr. Jamie Neidert, Mr. Paul Turner, Dr. Robin Buckelew, and Mr. Steve Cornelius for their patience and financial support. The authors acknowledge fruitful discussions with Mr. Scott Dawley (Aerojet Corporation), Dr. Ronald Clawson (ATK Corporation), and Dr. Joe Flanagan (Flanagan Enterprises). NR 84 TC 2 Z9 2 U1 2 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2012 VL 37 IS 1 BP 40 EP 51 DI 10.1002/prep.201100039 PG 12 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 897RB UT WOS:000300671200006 ER PT J AU Britt, TW Wright, KM Moore, D AF Britt, Thomas W. Wright, Kathleen M. Moore, DeWayne TI Leadership as a Predictor of Stigma and Practical Barriers Toward Receiving Mental Health Treatment: A Multilevel Approach SO PSYCHOLOGICAL SERVICES LA English DT Article DE stigma; treatment seeking; barriers to care; leadership; within-person ID ABUSIVE SUPERVISION; PERCEIVED STIGMA; CARE; IRAQ; AFGHANISTAN; SOLDIERS; CONSEQUENCES; PREVALENCE; STRESSORS; MILITARY AB The present research examined positive and negative leadership behaviors as predictors of stigma and practical barriers to mental health treatment. Soldiers completed measures of noncommissioned officer (NCO) and officer leadership, stigma, and practical barriers to getting mental health treatment at 2, 3, and 4 months following a 15-month deployment to Afghanistan. The results revealed that positive and negative NCO and officer leader behaviors were predictive of overall stigma and barriers to care (collapsed across the three time periods), with only NCO positive and negative behaviors being uniquely predictive of stigma when included in the same model with officer behaviors. In addition, negative and positive NCO leader behaviors were predictive of stigma within participants over the course of the three month time period, and positive NCO leader behaviors were inversely related to practical barriers to mental health treatment within participants across the same time period. The results are discussed in terms of how different leader behaviors may be linked to different factors influencing a soldier's decision to seek mental health treatment. C1 [Britt, Thomas W.; Wright, Kathleen M.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Heidelberg, Germany. [Moore, DeWayne] Clemson Univ, Dept Psychol, Clemson, SC 29631 USA. RP Britt, TW (reprint author), 418 Brackett Hall, Clemson, SC 29634 USA. EM twbritt@clemson.edu NR 33 TC 18 Z9 18 U1 0 U2 8 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 1541-1559 J9 PSYCHOL SERV JI Psychol. Serv. PD FEB PY 2012 VL 9 IS 1 BP 26 EP 37 DI 10.1037/a0026412 PG 12 WC Psychology, Clinical SC Psychology GA 896BW UT WOS:000300541400003 PM 22449085 ER PT J AU Sweeney, LM Gut, CP Gargas, ML Reddy, G Williams, LR Johnson, MS AF Sweeney, Lisa M. Gut, Chester P., Jr. Gargas, Michael L. Reddy, Gunda Williams, Larry R. Johnson, Mark S. TI Assessing the non-cancer risk for RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) using physiologically based pharmacokinetic (PBPK) modeling SO REGULATORY TOXICOLOGY AND PHARMACOLOGY LA English DT Article DE RDX; Physiologically-based pharmacokinetic model; PBPK; Reference dose ID BOBWHITE COLINUS-VIRGINIANUS; CYCLOTRIMETHYLENETRINITRAMINE RDX; EXPOSURE; 1,3,5-TRINITRO-1,3,5-TRIAZINE; TOXICITY; RAT AB RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) is an explosive used in military applications. It has been detected in ground water surrounding US military installations and at manufacturing facilities. RDX has been shown to produce hepatotoxicity, testicular, and neurological effects in animals, the latter also in humans. The current chronic oral reference dose (RfD) of 0.003 mg/kg/day was derived based on prostate effects in rats. Here, we provide a reevaluation of the risk associated with RDX exposure by examining old and new data and using physiologically based pharmacokinetic (PBPK) modeling approaches. Candidate non-cancer endpoints in rodents were evaluated and the most plausible mode(s) of action were determined. A PBPK model was used to derive appropriate internal doses based on the mode of action, and then a benchmark dose (BMD) and the lower confidence limit on the BMD (BMDL) were determined using these internal doses in animals. Uncertainty factors (UF) were applied to the animal BMDL or no-observed effect level and a human PBPK model was used to determine a human equivalent dose resulting in the candidate RfDs (cRfDs). A proposed chronic RfD of 0.07 mg/kg/day, based on multiple effects observed in rats, was selected from among the cRfDs. (C) 2011 Elsevier Inc. All rights reserved. C1 [Sweeney, Lisa M.; Gut, Chester P., Jr.; Gargas, Michael L.] USN, Med Res Unit Dayton, Wright Patterson AFB, OH 45433 USA. [Reddy, Gunda; Williams, Larry R.; Johnson, Mark S.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. RP Sweeney, LM (reprint author), USN, Med Res Unit Dayton, 2729 R St, Wright Patterson AFB, OH 45433 USA. EM lisa.sweeney.ctr@wpafb.af.mil RI Sweeney, Lisa/K-5114-2012 OI Sweeney, Lisa/0000-0002-4672-7358 FU US Army Environmental Command [61063] FX This work was sponsored by the US Army Environmental Command, Installation Restoration Program, under Work Unit Number 61063; Army personnel who are listed co-authors contributed to the interpretation of the data, the preparation of the manuscript, and the decision to submit the paper for publication. NR 35 TC 4 Z9 4 U1 3 U2 13 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0273-2300 J9 REGUL TOXICOL PHARM JI Regul. Toxicol. Pharmacol. PD FEB PY 2012 VL 62 IS 1 BP 107 EP 114 DI 10.1016/j.yrtph.2011.12.007 PG 8 WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology SC Legal Medicine; Pharmacology & Pharmacy; Toxicology GA 887XN UT WOS:000299965400012 PM 22197625 ER PT J AU Mitchell, MM Knowlton, A AF Mitchell, Mary M. Knowlton, Amy TI Caregiver Role Overload and Network Support in a Sample of Predominantly Low-Income, African-American Caregivers of Persons Living with HIV/AIDS: A Structural Equation Modeling Analysis SO AIDS AND BEHAVIOR LA English DT Article DE HIV/AIDS; Caregivers; Role overload; Social network; Social support ID INJECTION-DRUG USERS; SOCIAL SUPPORT; ANTIRETROVIRAL THERAPY; AIDS CAREGIVERS; STRESS PROCESS; UNITED-STATES; HIV; DEPRESSION; BURDEN; POPULATION AB While informal caregivers play an important role in improving the health of disadvantaged persons living with HIV/AIDS (PLHAs) in the United States, caregiver role overload has the potential for distress. We used latent profile analysis (LPA) to classify caregivers based on their perceived level of support and structural equation modeling (SEM) to examine the relationships among role overload, perceived support, caregiver demographic characteristics, and social network members' characteristics in a sample of 215 predominantly low-income, African-American informal caregivers. The LPA resulted in two classes of caregivers with higher and lower perceived support. The SEM results indicated that caregiver role overload was associated with being in the less supported class, younger age, and limited physical functioning, while social support class was associated with being female and being HIV seropositive in addition to support network characteristics. Interventions should address the support needs of HIV caregivers to reduce their potential for distress. C1 [Mitchell, Mary M.] USA, Publ Hlth Command, Aberdeen, MD 21010 USA. [Knowlton, Amy] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA. RP Mitchell, MM (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd,Bldg 1570, Aberdeen, MD 21010 USA. EM marymitch1@yahoo.com FU NIDA NIH HHS [R01 DA019413, R01 DA13142-01A1] NR 46 TC 6 Z9 6 U1 1 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-7165 J9 AIDS BEHAV JI AIDS Behav. PD FEB PY 2012 VL 16 IS 2 BP 278 EP 287 DI 10.1007/s10461-011-9886-1 PG 10 WC Public, Environmental & Occupational Health; Social Sciences, Biomedical SC Public, Environmental & Occupational Health; Biomedical Social Sciences GA 892HW UT WOS:000300278300004 PM 21259041 ER PT J AU Ahmed, Y Schimel, AM Pathengay, A Colyer, MH Flynn, HW AF Ahmed, Y. Schimel, A. M. Pathengay, A. Colyer, M. H. Flynn, H. W., Jr. TI Endophthalmitis following open-globe injuries SO EYE LA English DT Article DE endophthalmitis; open globe; traumatic; bacillus; antibiotic prophylaxis; retinal detachment ID INTRAOCULAR FOREIGN-BODIES; PERFORATING EYE INJURIES; PARS-PLANA VITRECTOMY; POSTTRAUMATIC ENDOPHTHALMITIS; BACTERIAL ENDOPHTHALMITIS; PROGNOSTIC-FACTORS; SILICONE OIL; INFECTIOUS ENDOPHTHALMITIS; TRAUMATIC ENDOPHTHALMITIS; MICROBIOLOGIC SPECTRUM AB The incidence of traumatic endophthalmitis may be decreasing due to earlier wound closure and prompt initiation of antibiotics. Risk factors for endophthalmitis include retained intraocular foreign body, rural setting of injury, disruption of the crystalline lens, and a delay in primary wound closure. The microbiology in the post-traumatic setting includes a higher frequency of virulent organisms such as Bacillus species. Recognizing early clinical signs of endophthalmitis, including pain, hypopyon, vitritis, or retinal periphlebitis may prompt early treatment with intravitreal antibiotics. Prophylaxis of endophthalmitis in high-risk open-globe injuries may include systemic broad-spectrum antibiotics, topical antibiotics, and intravitreal antibiotics to cover both Gram-positive and Gram-negative bacteria. For clinically diagnosed post-traumatic endophthalmitis, intravitreal vancomycin, and ceftazidime are routinely used. Concurrent retinal detachment with endophthalmitis can be successfully managed with vitrectomy and use of intravitreal antibiotics along with a long acting gas or silicone oil tamponade. Endophthalmitis is a visually significant complication of open-globe injuries but early wound closure as well as comprehensive prophylactic antibiotic treatment at the time of injury repair may improve visual acuity outcomes. Eye (2012) 26, 212-217; doi:10.1038/eye.2011.313; published online 2 December 2011 C1 [Ahmed, Y.; Schimel, A. M.; Pathengay, A.; Flynn, H. W., Jr.] Univ Miami, Dept Ophthalmol, Bascom Palmer Eye Inst, Miller Sch Med, Miami, FL 33136 USA. [Colyer, M. H.] Walter Reed Army Med Ctr, Dept Ophthalmol, Bethesda, MD USA. [Colyer, M. H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Flynn, HW (reprint author), Univ Miami, Dept Ophthalmol, Bascom Palmer Eye Inst, Miller Sch Med, 900 NW 17th St, Miami, FL 33136 USA. EM hflynn@med.miami.edu FU National Institutes of Health, Bethesda, MD, USA [P30-EY014801]; Research to Prevent Blindness, New York, NY, USA FX This study is supported in part by Grant P30-EY014801 from the National Institutes of Health, Bethesda, MD, USA and an unrestricted grant to the University of Miami from Research to Prevent Blindness, New York, NY, USA. NR 49 TC 28 Z9 31 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0950-222X J9 EYE JI Eye PD FEB PY 2012 VL 26 IS 2 BP 212 EP 217 DI 10.1038/eye.2011.313 PG 6 WC Ophthalmology SC Ophthalmology GA 892UX UT WOS:000300312200005 PM 22134598 ER PT J AU Chaudhury, S Olson, MA Tawa, G Wallqvist, A Lee, MS AF Chaudhury, Sidhartha Olson, Mark A. Tawa, Gregory Wallqvist, Anders Lee, Michael S. TI Efficient Conformational Sampling in Explicit Solvent Using a Hybrid Replica Exchange Molecular Dynamics Method SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID GUIDED LANGEVIN DYNAMICS; FREE-ENERGY LANDSCAPE; SIMULATION METHOD; PROTEIN; MODEL; IMPLICIT; BIOMOLECULES; ENERGETICS; CHIGNOLIN; TRP AB Temperature-based replica-exchange molecular dynamics (REMD), in which multiple simultaneous simulations, or replicas, are run at a range of temperatures, has become increasingly popular for exploring the energy landscape of biomolecular systems. The practical application of REMD toward systems of biomedical interest is often limited by the rapidly increasing number of replicas needed to model systems of larger size. Continuum solvent models, which replace the explicit modeling of solvent molecules with a mean-field approximation of solvation, decrease system size and correspondingly, the number of replicas, but can sometimes produce distortions of the free energy landscape. We present a hybrid implicit/explicit solvent REMD method in CHARMM in which replicas run in a purely explicit solvent regime while exchanges are implemented with a high-density GBMV2 implicit solvation model. Such a hybrid approach may be able to decrease the number of replicas needed to model larger systems while maintaining the accuracy of explicit solvent simulations. Toward that end, we run REMD) using implicit solvent, explicit solvent, and our hybrid method, on three model systems: alanine dipeptide, a zwitterionic tetra-peptide, and a 10-residue beta-hairpin peptide. We compare free energy landscape in each system derived from a variety of metrics including dihedral torsion angles, salt-bridge distance, and folding stability, and perform clustering to characterize the resulting structural ensembles. Our results identify discrepancies in the free-energy landscape between implicit and explicit solvent and evaluate the capability of the hybrid approach to decrease the number of replicas needed for REMD while reproducing the energy landscape of explicit solvent simulations. C1 [Chaudhury, Sidhartha; Tawa, Gregory; Wallqvist, Anders] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Ft Detrick, MD 21702 USA. [Lee, Michael S.] USA, Computat Sci & Engn Branch, Res Lab, Aberdeen Proving Ground, MD USA. RP Chaudhury, S (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. EM schaudhury@bioanalysis.org OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Department of Defense Threat Reduction Agency [TMTI0004_09_BH_T]; Department of Defense Biotechnology High Performance Computing Software Applications Institute FX Funding of this research was provided by the U.S. Department of Defense Threat Reduction Agency Grant TMTI0004_09_BH_T and the Department of Defense Biotechnology High Performance Computing Software Applications Institute. Computational time was provided by the U.S. Army Research Laboratory DoD Supercomputing Resource Center and the Maui High Performance Computing Center. Additional computational resources were provided by the Advanced Biomedical Computing Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. NR 31 TC 13 Z9 13 U1 0 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD FEB PY 2012 VL 8 IS 2 BP 677 EP 687 DI 10.1021/ct200529b PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 890JT UT WOS:000300141600029 PM 26596615 ER PT J AU Sutorik, AC Gilde, G Swab, JJ Cooper, C Gamble, R Shanholtz, E AF Sutorik, Anthony C. Gilde, Gary Swab, Jeffrey J. Cooper, Christopher Gamble, Robert Shanholtz, Eugene TI Transparent Solid Solution Magnesium Aluminate Spinel Polycrystalline Ceramic with the Alumina-Rich Composition MgO center dot 1.2 Al2O3 SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID MGAL2O4 SPINEL; MICROSTRUCTURE DEVELOPMENT; MGO.2AL2O3 SPINEL; GRAIN-GROWTH; POWDER; FABRICATION AB Solid solution magnesium aluminate spinel with the alumina-rich composition MgO center dot 1.2 Al2O3 has been prepared as a transparent polycrystalline ceramic with average in-line transmission at 550 nm of 84.8 +/- 2.7% and >82% throughout the visible spectrum. Starting powders are prepared from mixtures of high purity Mg(OH)(2) and gamma-Al2O3 thoroughly mixed in an aqueous slurry. Water is removed by rotary evaporation. The solids are collected, dried, calcined, mixed with LiF (as a sintering aid), and sieved. The powders are sintered into dense ceramics by hot pressing at 1600 degrees C under vacuum and 20 MPa uniaxial load followed by hot isostatic pressing at 1850 degrees C under 200 MPa Ar. Final grain sizes ranged between 300 and 1000 mu m. Samples exhibited flexural strength of 176.8 +/- 46.2 MPa; hardness of 12.3 +/- 0.2 GPa; and elastic modulus of 292.9 +/- 7.5 GPa. Control samples of stoichiometric magnesium aluminate spinel (MgO center dot Al2O3) were prepared with the same procedure and exhibited comparable values for transmission and physical properties. C1 [Sutorik, Anthony C.; Gilde, Gary; Swab, Jeffrey J.; Cooper, Christopher; Gamble, Robert; Shanholtz, Eugene] USA, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. RP Sutorik, AC (reprint author), USA, Res Lab, RDRL WMM E, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM anthony.sutorik1@us.army.mil NR 39 TC 12 Z9 12 U1 3 U2 35 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD FEB PY 2012 VL 95 IS 2 BP 636 EP 643 DI 10.1111/j.1551-2916.2011.04798.x PG 8 WC Materials Science, Ceramics SC Materials Science GA 884UA UT WOS:000299733100033 ER PT J AU Arrigo, NC Briese, T Calisher, CH Drebot, MA Fljelle, B LeDuc, JW Powers, AM Repik, PM Roehrig, JT Schmaljohn, CS Tesh, RB Weaver, SC AF Arrigo, Nicole C. Briese, Thomas Calisher, Charles H. Drebot, Michael A. Fljelle, Brian LeDuc, James W. Powers, Ann M. Repik, Patricia M. Roehrig, John T. Schmaljohn, Connie S. Tesh, Robert B. Weaver, Scott C. TI Recommendations for Publication of Viral Genetic Data and Sample Access for Novel Viruses and Strains SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DEPENDENT DNA POLYMERASE; VIRIONS C1 [LeDuc, James W.; Tesh, Robert B.; Weaver, Scott C.] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA. [Arrigo, Nicole C.; Briese, Thomas] Columbia Univ, Ctr Infect & Immun, Mailman Sch Publ Hlth, New York, NY USA. [Calisher, Charles H.] Colorado State Univ, Arthropod Borne & Infect Dis Lab, Dept Microbiol Immunol & Pathol, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA. [Drebot, Michael A.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada. [Fljelle, Brian] Univ New Mexico, Sch Med, Infect Dis & Inflammat Program, Dept Pathol Biol & Mol Genet, Albuquerque, NM 87131 USA. [Fljelle, Brian] Univ New Mexico, Sch Med, Infect Dis & Inflammat Program, Dept Microbiol, Albuquerque, NM 87131 USA. [Powers, Ann M.; Roehrig, John T.] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Vector Borne Infect Dis, Ft Collins, CO USA. [Repik, Patricia M.] NIAID, Virol Branch, Div Microbiol & Infect Dis, NIH, Bethesda, MD 20892 USA. [Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Frederick, MD USA. RP Weaver, SC (reprint author), Univ Texas Med Branch, Inst Human Infect & Immun, 301 Univ Blvd, Galveston, TX 77555 USA. EM ncarrigo@gmail.com; thomas.briese@columbia.edu; calisher@cybersafe.net; Mike_Drebot@hc-sc.gc.ca; bhjelle@salud.unm.edu; jwleduc@UTMB.EDU; AKP7@cdc.gov; prepik@niaid.nih.gov; trl@CDC.GOV; connie.schmaljohn@us.army.mil; rtesh@utmb.edu; sweaver@utmb.edu RI Weaver, Scott/D-6490-2011; OI Roehrig, John/0000-0001-7581-0479 NR 5 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 2012 VL 86 IS 2 BP 189 EP 191 DI 10.4269/ajtmh.2012.11-0523 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 886PQ UT WOS:000299866700002 PM 22302845 ER PT J AU Gorbunov, NV Atkins, JL Gurusamy, N Pitt, BR AF Gorbunov, Nikolai V. Atkins, James L. Gurusamy, Narasimman Pitt, Bruce R. TI Iron-induced remodeling in cultured rat pulmonary artery endothelial cells SO BIOMETALS LA English DT Article DE Iron complexes; Endothelial cells; Remodeling; Inflammation; Redox-stress ID TRANSFERRIN-BOUND IRON; LABILE PLASMA IRON; LEUKOCYTE DIAPEDESIS; OXIDATIVE STRESS; FOCAL ADHESION; OVERLOAD; INJURY; LUNG; PERMEABILITY; MICROVESSELS AB Although iron is known to be a component of the pathogenesis and/or maintenance of acute lung injury (ALI) in experimental animals and human subjects, the majority of these studies have focused on disturbances in iron homeostasis in the airways resulting from exposure to noxious gases and particles. Considerably less is known about the effect of increased plasma levels of redox-reactive non-transferrin bound iron (NTBI) and its impact on pulmonary endothelium. Plasma levels of NTBI can increase under various pathophysiological conditions, including those associated with ALI, and multiple mechanisms are in place to affect the [Fe2+]/[Fe3+] redox steady state. It is well accepted, however, that intracellular transport of NTBI occurs after reduction of [Fe3+] to [Fe2+] (and is mediated by divalent metal transporters). Accordingly, as an experimental model to investigate mechanisms mediating vascular effects of redox reactive iron, rat pulmonary artery endothelial cells (RPAECs) were subjected to pulse treatment (10 min) with [Fe2+] nitriloacetate (30 mu M) in the presence of pyrithione, an iron ionophore, to acutely increase intracellular labile pool of iron. Cellular iron influx and cell shape profile were monitored with time-lapse imaging techniques. Exposure of RPAECs to [Fe2+] resulted in: (i) an increase in intracellular iron as detected by the iron sensitive fluorophore, PhenGreen; (ii) depletion of cell glutathione; and (iii) nuclear translocation of stress-response transcriptional factors Nrf2 and NFkB (p65). The resulting iron-induced cell alterations were characterized by cell polarization and formation of membrane cuplike and microvilli-like projections abundant with ICAM-1, caveolin-1, and F-actin. The iron-induced re-arrangements in cytoskeleton, alterations in focal cell-cell interactions, and cell buckling were accompanied by decrease in electrical resistance of RPAEC monolayer. These effects were partially eliminated in the presence of N,N'-bis (2-hydroxybenzyl) ethylenediamine-N,N'-diacetic acid, an iron chelator, and Y27632, a Rho-kinase inhibitor. Thus acute increases in labile iron in cultured pulmonary endothelium result in structural remodeling (and a proinflammatory phenotype) that occurs via post-transcriptional mechanisms regulated in a redox sensitive fashion. C1 [Gorbunov, Nikolai V.] Henry Jackson Fdn Adv Mil Med Inc, Washington, DC USA. [Gorbunov, Nikolai V.; Pitt, Bruce R.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Environm & Occupat Hlth, Pittsburgh, PA 15219 USA. [Gorbunov, Nikolai V.; Atkins, James L.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Gurusamy, Narasimman] Univ Connecticut, Cardiovasc Res Ctr, Sch Med, Farmington, CT 06030 USA. RP Gorbunov, NV (reprint author), 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Nikolaiv.gorbunov@gmx.us FU Department of the Army [PR033201]; US Army Medical Research; Materiel Command; [R37 NIH HL65697] FX The authors thank Dr. Yulia Y Tyurina, and Dr. Valerian E Kagan for their help with assessment of cell glutathione and Mr. Geoff Daniels (Leica Microsystems Inc.) for the confocal imaging consulting. This study was supported by the Department of the Army Peer Reviewed Medical Research Program (Grant No. PR033201 to J L A.), by the US Army Medical Research and Materiel Command and R37 NIH HL65697 (B R P.). NR 41 TC 3 Z9 3 U1 2 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0966-0844 J9 BIOMETALS JI Biometals PD FEB PY 2012 VL 25 IS 1 BP 203 EP 217 DI 10.1007/s10534-011-9498-2 PG 15 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 881LA UT WOS:000299485000018 PM 22089858 ER PT J AU Johnson, WC Dixon, MD Scott, ML Rabbe, L Larson, G Volke, M Werner, B AF Johnson, W. Carter Dixon, Mark D. Scott, Michael L. Rabbe, Lisa Larson, Gary Volke, Malia Werner, Brett TI Forty Years of Vegetation Change on the Missouri River Floodplain SO BIOSCIENCE LA English DT Article DE riparian; cottonwood; deltas; restoration; reservoirs ID REGULATED RIVERS; GREAT-PLAINS; RIPARIAN VEGETATION; SOUTHERN ALBERTA; NORTH-DAKOTA; DOWNSTREAM; DAMS; FOREST; BOTTOMLAND; RESTORATION AB Comparative inventories in 1969 and 1970 and in 2008 of vegetation from 30 forest stands downstream of Garrison Dam on the Missouri River in central North Dakota showed (a) a sharp decline in cottonwood regeneration; (b) a strong compositional shift toward dominance by green ash; and (c) large increases in invasive understory species, such as smooth brome, reed canary grass, and Canada thistle. These changes, and others discovered during remeasurement, have been caused by a complex of factors, some related to damming (altered hydrologic and sediment regimes, delta formation, and associated wet-dry cycles) and some not (diseases and expansion of invasive plants). Dominance of green ash, however, may be short lived, given the likelihood that the emerald ash borer will arrive in the Dakotas in 5-10 years, with potentially devastating effects. The prospects for recovery of this valuable ecosystem, rich in ecosystem goods and services and in American history, are daunting. C1 [Johnson, W. Carter; Larson, Gary; Volke, Malia; Werner, Brett] S Dakota State Univ, Dept Nat Resource Management, Brookings, SD 57007 USA. [Dixon, Mark D.] Univ S Dakota, Dept Biol, Vermillion, SD 57069 USA. [Scott, Michael L.] US Geol Survey, Ft Collins, CO USA. [Rabbe, Lisa] USA, Corps Engineers, Kansas City, MO USA. RP Johnson, WC (reprint author), S Dakota State Univ, Dept Nat Resource Management, Brookings, SD 57007 USA. EM carter.johnson@sdstate.edu RI Dixon, Mark/F-2641-2011 OI Dixon, Mark/0000-0002-0345-5655 FU US Army Corps of Engineers, Kansas City Office FX Funding for this research was provided by the US Army Corps of Engineers, Kansas City Office. Warren Keammerer and Deborah Keammerer collected the forest understory data in 1969 and 1970. Dale Kohlmetz, Jennifer Young, Brittany A. Hummel, Keir A. Morse, and Tara L. Kline collected all field data in 2008. We also thank the many riparian landowners who allowed us to access their property and to sample their forests (some of them twice). We thank Waite Osterkamp for reviewing an early draft of the manuscript and for making helpful suggestions. This article is dedicated to the late Robert L. Burgess, whose foresight to investigate the ecological effects of darns on the newly impounded Missouri River made this long-term study possible. NR 61 TC 24 Z9 26 U1 6 U2 53 PU AMER INST BIOLOGICAL SCI PI WASHINGTON PA 1444 EYE ST, NW, STE 200, WASHINGTON, DC 20005 USA SN 0006-3568 J9 BIOSCIENCE JI Bioscience PD FEB PY 2012 VL 62 IS 2 BP 123 EP 135 DI 10.1525/bio.2012.62.2.6 PG 13 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 890DJ UT WOS:000300125000005 ER PT J AU Stewart, IJ Tilley, MA Cotant, CL Aden, JK Gisler, C Kwan, HK McCorcle, J Renz, EM Chung, KK AF Stewart, Ian J. Tilley, Molly A. Cotant, Casey L. Aden, James K. Gisler, Christopher Kwan, Hana K. McCorcle, Jeffery Renz, Evan M. Chung, Kevin K. TI Association of AKI with Adverse Outcomes in Burned Military Casualties SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article ID ACUTE KIDNEY INJURY; ACUTE-RENAL-FAILURE; INTENSIVE-CARE-UNIT; LONG-TERM RISK; HOSPITALIZED-PATIENTS; CONTEMPORARY ANALYSIS; RIFLE CRITERIA; MORTALITY; CREATININE; INCREASES AB Background and objectives Although associated with increased morbidity and mortality, AKI has not been systematically examined in military personnel injured from combat operations in Iraq and Afghanistan. Design, settings, participants, & measurements Patients evacuated from Iraq and Afghanistan to a burn unit were examined. AKI was classified by the Acute Kidney Injury Network (AKIN) and Risk-Injury-Failure-Loss-End Stage (RIFLE) schemas. Age, sex, percentage of total body surface area burned (TBSA), percentage of full-thickness burn, inhalation injury, and injury severity score were recorded. Additional data that could be associated with poor outcomes were recorded for patients with TBSA >= 20%. Multivariate logistic regression analyses were performed to determine factors associated with morbidity and mortality. Results AKI prevalence rates by the RIFLE and AKIN criteria were 23.8% and 29.9%, respectively. After logistic regression, RIFLE categories of risk (odds ratio [OR], 15.34; 95% confidence interval [CI], 1.75-134; P=0.01), injury (OR, 46.28; 95% CI, 5.02-427; P<0.001), and failure (OR, 126; 95% CI, 13.39 -> 999; P<0.001); AKIN-2 (OR, 23.70; 95% CI, 2.32-242; P=0.008); and AKIN-3 (OR, 130; 95% CI, 13.38 -> 999; P<0.001) were significantly associated with death. AKIN-3, injury, and failure remained significant in the subset of patients with >= 20% TBSA. There was also a strong interaction between TBSA and the stage of AKI with respect to ventilator and intensive care unit days. Conclusions AKI is prevalent in military casualties with burn injury and is independently associated with morbidity and mortality after adjustment for factors associated with injury severity. Clin J Are Soc Nephrol 7: 199-206, 2012. doi: 10.2215/CJN.04420511 C1 [Stewart, Ian J.; Tilley, Molly A.; Cotant, Casey L.; Kwan, Hana K.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Aden, James K.; McCorcle, Jeffery; Renz, Evan M.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Gisler, Christopher] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Stewart, IJ (reprint author), San Antonio Mil Med Ctr, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM ian.stewart@us.af.mil NR 26 TC 16 Z9 17 U1 1 U2 2 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1555-9041 J9 CLIN J AM SOC NEPHRO JI Clin. J. Am. Soc. Nephrol. PD FEB PY 2012 VL 7 IS 2 BP 199 EP 206 DI 10.2215/CJN.04420511 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 890DC UT WOS:000300124300003 PM 22156751 ER PT J AU Churaman, WA Currano, LJ Morris, CJ Rajkowski, JE Bergbreiter, S AF Churaman, Wayne A. Currano, Luke J. Morris, Christopher J. Rajkowski, Jessica E. Bergbreiter, Sarah TI The First Launch of an Autonomous Thrust-Driven Microrobot Using Nanoporous Energetic Silicon SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Autonomy; microrobot; porous silicon ID ROBOT AB As the capability and complexity of robotic platforms continue to evolve from the macro to the micron scale, the challenge of achieving autonomy requires the development of robust, lightweight architectures. These architectures must provide a platform upon which actuators, control, sensing, power, and communication modules are integrated for optimal performance. In this paper, the first autonomous jumping microrobotic platform is demonstrated using a hybrid integration approach to assemble on-board control, sensing, power, and actuation directly onto a polymer chassis. For the purposes of this paper, jumping is defined as brief parabolic motion achieved via an actuation pulse at takeoff. In this paper, the actuation pulse comes from the rapid release of chemical energy to create propulsion. The actuation pulse lasts several microseconds and is achieved using a novel high-force/low-power thrust actuator, nanoporous energetic silicon, resulting in 250 mu J of kinetic energy delivered to the robot and a vertical height of approximately 8 cm. [2011-0030] C1 [Churaman, Wayne A.; Currano, Luke J.; Morris, Christopher J.] USA, Res Lab, Adelphi, MD 20783 USA. [Bergbreiter, Sarah] Univ Maryland, Dept Mech Engn, College Pk, MD 20783 USA. RP Churaman, WA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM wayne.a.churaman.civ@mail.mil; luke.j.currano.civ@mail.mil; christopher.j.morris58.civ@mail.mil; jrajkowski@mitre.org; sarahb@umd.edu RI Bergbreiter, Sarah /F-4449-2014 OI Bergbreiter, Sarah /0000-0003-2735-0206 FU U.S. Army Research Laboratory; National Science Foundation [CNS0931878] FX This work was supported by the U.S. Army Research Laboratory. This work was also supported in part by the National Science Foundation under Award CNS0931878. Subject Editor C. Mastrangelo. NR 21 TC 15 Z9 15 U1 4 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD FEB PY 2012 VL 21 IS 1 BP 198 EP 205 DI 10.1109/JMEMS.2011.2174414 PG 8 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 889WA UT WOS:000300104600022 ER PT J AU Freedman, BA Rhee, JM Jackson, KL AF Freedman, Brett A. Rhee, John M. Jackson, Keith L. TI Preparing the Lumbar Intervertebral Disk Space for Interbody Procedures A Comparison Between the Traditional Method and a New Automated Method SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE disk-space preparation; nucleus pulposus; spinal fusion surgery ID BONE-MINERAL DENSITY; SPINAL-FUSION; END-PLATES; COMPLICATIONS; GRAFT; INTERFACE; STRENGTH; CAGE AB Study Design: Cadaveric laboratory study. Objective: To quantify and compare automated disk-space preparation with traditional methods. Summary of Background Data: Removal of nucleus pulposus to prepare a disk space for interbody fusion is performed with various techniques. Our aim was to determine the safety and effectiveness of an automated technique in comparison to traditional methods and gauge its expected clinical application. Methods: This study was conducted in 2 phases. In the phase 1 safety trial, "maximal" force was applied to an automated shaver against cadaveric annulus and endplates until flexion of the shaft caused the blades to bind. This simulated the risk of creating an incidental cortical or annular defect. In phase 2, 27 cadaveric lumbar disk spaces were randomized to traditional or automated preparation techniques through a standard transforaminal lumbar interbody fusion approach. Traditional method comprised the use of paddle shavers, pituitary rongeurs, and curettes. Automated technique involved insertion of an 8-mm paddle shaver, followed by straight and angled hand pieces to remove nucleus pulposus and endplate cartilage. Unintended cortical and annular breaches, preparation time, instrument insertions, percentage area of exposed endplate underlying the nucleus pulposus, and percentage volume of nuclear space cleared were measured and compared. Results: In phase 1, "maximal" force applied for 10 seconds produced no full-thickness annular or cortical defects. In phase 2, automated technique produced fewer endplate cortical defects (3 vs. 7) and full-thickness annular breaches (0 vs. 1), required fewer instrument insertions (29 vs. 6; P < 0.001), exposed more endplate (65% vs. 52%; P = 0.037), and removed more nucleus pulposus volume (83% vs. 59%; P = 0.01). Conclusions: Automated shaving decreased instrument insertions and prepared the disk space more effectively, with fewer cortical or annular defects. This technique holds promise for improved outcomes in spinal fusion surgery. C1 [Freedman, Brett A.; Rhee, John M.] Emory Univ, Orthopaed & Spine Ctr, Dept Orthopaed Surg, S Atlanta, GA 30329 USA. [Jackson, Keith L.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Freedman, BA (reprint author), Emory Univ, Orthopaed & Spine Ctr, Dept Orthopaed Surg, 59 Execut Pk, S Atlanta, GA 30329 USA. EM brettfreedman@yahoo.com FU Medtronic FX The cadaveric specimens, automated shaver device and disposables, laboratory space, and supplies were funded through an educational grant awarded by Medtronic. The study design, data analysis, and presentation were performed independently of Medtronic. The authors received no direct financial compensation for participation in this study. In addition, none of the authors maintain any financial interest in Medtronic. NR 25 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 EI 1539-2465 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD FEB PY 2012 VL 25 IS 1 BP E1 EP E6 DI 10.1097/BSD.0b013e318227ecfb PG 6 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 889AU UT WOS:000300046700001 PM 21738073 ER PT J AU Smith, DR Bird, BH Lewis, B Johnston, SC McCarthy, S Keeney, A Botto, M Donnelly, G Shamblin, J Albarino, CG Nichol, ST Hensley, LE AF Smith, Darci R. Bird, Brian H. Lewis, Bridget Johnston, Sara C. McCarthy, Sarah Keeney, Ashley Botto, Miriam Donnelly, Ginger Shamblin, Joshua Albarino, Cesar G. Nichol, Stuart T. Hensley, Lisa E. TI Development of a Novel Nonhuman Primate Model for Rift Valley Fever SO JOURNAL OF VIROLOGY LA English DT Article ID MARMOSETS CALLITHRIX-JACCHUS; ENZOOTIC HEPATITIS; INFECTED MARMOSETS; LIVER PATHOLOGY; RHESUS-MONKEYS; VIRUS-STRAINS; SOUTH-AFRICA; PUNTA-TORO; PATHOGENESIS; DISEASE AB Rift Valley fever (RVF) virus (RVFV) can cause severe human disease characterized by either acute-onset hepatitis, delayed-onset encephalitis, retinitis and blindness, or a hemorrhagic syndrome. The existing nonhuman primate (NHP) model for RVF utilizes an intravenous (i.v.) exposure route in rhesus macaques (Macaca mulatta). Severe disease in these animals is infrequent, and large cohorts are needed to observe significant morbidity and mortality. To overcome these drawbacks, we evaluated the infectivity and pathogenicity of RVFV in the common marmoset (Callithrix jacchus) by i.v., subcutaneous (s.c.), and intranasal exposure routes to more closely mimic natural exposure. Marmosets were more susceptible to RVFV than rhesus macaques and experienced higher rates of morbidity, mortality, and viremia and marked aberrations in hematological and chemistry values. An overwhelming infection of hepatocytes was a major consequence of infection of marmosets by the i.v. and s.c. exposure routes. Additionally, these animals displayed signs of hemorrhagic manifestations and neurological impairment. Based on our results, the common marmoset model more closely resembles severe human RVF disease and is therefore an ideal model for the evaluation of potential vaccines and therapeutics. C1 [Smith, Darci R.; Lewis, Bridget; Johnston, Sara C.; McCarthy, Sarah; Keeney, Ashley; Botto, Miriam; Donnelly, Ginger; Shamblin, Joshua; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Bird, Brian H.; Albarino, Cesar G.; Nichol, Stuart T.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Atlanta, GA USA. RP Smith, DR (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM darci.smith1@us.army.mil FU Science and Technology Directorate of the U.S. Department of Homeland Security [HSHQDC-09-00568] FX This project was funded through an interagency agreement with the Science and Technology Directorate of the U.S. Department of Homeland Security under award number HSHQDC-09-00568. NR 48 TC 32 Z9 32 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD FEB PY 2012 VL 86 IS 4 BP 2109 EP 2120 DI 10.1128/JVI.06190-11 PG 12 WC Virology SC Virology GA 886OA UT WOS:000299862500020 PM 22156530 ER PT J AU Sweany, M Bernstein, A Dazeley, S Dunmore, J Felde, J Svoboda, R Tripathi, M AF Sweany, M. Bernstein, A. Dazeley, S. Dunmore, J. Felde, J. Svoboda, R. Tripathi, M. TI Study of wavelength-shifting chemicals for use in large-scale water Cherenkov detectors SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT LA English DT Article DE Wavelength-shifters; Cherenkov; Neutron detection ID DYE AB Cherenkov detectors employ various methods to maximize light collection at the photomultiplier tubes (PMTs). These generally involve the use of highly reflective materials lining the interior of the detector, reflective materials around the PMTs, or wavelength-shifting sheets around the PMTs. Recently, the use of water-soluble wavelength-shifters has been explored to increase the measurable light yield of Cherenkov radiation in water. These wave-shifting chemicals are capable of absorbing light in the ultraviolet and re-emitting the light in a range detectable by PMTs. Using a 250 L water Cherenkov detector, we have characterized the increase in light yield from three compounds in water: 4-Methylumbelliferone, Carbostyril-124, and Amino-G Salt. We report the gain in PMT response at a concentration of 1 ppm as 1.88 +/- 0.02 for 4-Methylumbelliferone, stable within 0.5% over 50 days, 1.37 +/- 0.03 for Carbostyril-124, and 1.20 +/- 0.02 for Amino-G Salt. The response of 4-Methylumbelliferone was modeled, resulting in a simulated gain within 9% of the experimental gain at 1 ppm concentration. Finally, we report an increase in neutron detection performance of a large-scale (3.5 kL) gadolinium-doped water Cherenkov detector at a 4-Methylumbelliferone concentration of 1 ppm. (C) 2011 Elsevier B.V. All rights reserved. C1 [Sweany, M.; Bernstein, A.; Dazeley, S.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Sweany, M.; Felde, J.; Svoboda, R.; Tripathi, M.] Univ Calif Davis, Dept Phys, Davis, CA 95616 USA. [Dunmore, J.] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA. RP Sweany, M (reprint author), Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. EM mdsweany@gmail.com FU DOE [NA-22]; Nuclear Science and Engineering Research Center at the United States Military Academy; US Department of Energy by Lawrence Livermore National Laboratory [DE-AC52-07NA27344] FX The authors wish to thank Dennis Carr for engineering support and Nathaniel Bowden for helpful discussions. We would also like to thank the DOE NA-22 and the Nuclear Science and Engineering Research Center at the United States Military Academy for their support of this project. This work was performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. Document release number LLNL-JRNL-502992. NR 8 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9002 J9 NUCL INSTRUM METH A JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip. PD FEB 1 PY 2012 VL 664 IS 1 BP 245 EP 250 DI 10.1016/j.nima.2011.10.064 PG 6 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA 882VM UT WOS:000299592000033 ER PT J AU Stanger, MJ Thompson, LA Young, AJ Lieberman, HR AF Stanger, Michael J. Thompson, Lauren A. Young, Andrew J. Lieberman, Harris R. TI Anticoagulant activity of select dietary supplements SO NUTRITION REVIEWS LA English DT Review DE adverse events; antiplatelet; hemorrhage; hemostasis; supplements ID N-3 FATTY-ACIDS; AGED GARLIC EXTRACT; OF-THE-LITERATURE; INHIBIT PLATELET-AGGREGATION; VITAMIN-E SUPPLEMENTATION; GINKGO-BILOBA; HEALTHY-VOLUNTEERS; FISH-OIL; DOUBLE-BLIND; ALPHA-TOCOPHEROL AB This review considers the potential of certain dietary supplements, including garlic, Ginkgo biloba, ginger, ginseng, fish oil, and vitamin E, to interfere with hemostasis. Dietary supplements are common components of the diet in the United States, with about half the US adult population taking some type of dietary supplement regularly. It has been suggested that some supplements could adversely affect coagulation when taken alone or in combination with antiplatelet medications. Supplements could alter hemostasis by a variety of mechanisms, such as reducing platelet aggregation or inhibiting arachidonic acid, a cellular signaling messenger and inflammatory intermediate. To conduct this review, multiple databases were searched using a variety of search terms to ensure relevant papers were located. Moderate to severe adverse events, such as spinal epidural hematoma, spontaneous intracerebral hemorrhage, retrobulbar hemorrhage, subarachnoid hemorrhage, spontaneous hyphema, and postoperative bleeding, have occasionally been anecdotally associated with consumption of dietary supplements. However, the number of controlled studies in the literature is too limited to demonstrate consistent anticoagulant effects of dietary supplements alone or in combination with drug therapy. C1 [Stanger, Michael J.; Thompson, Lauren A.; Young, Andrew J.; Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU US Army Medical Research and Materiel Command (USAMRMC); Department of Defense Center Alliance for Dietary Supplements Research FX This work was supported by the US Army Medical Research and Materiel Command (USAMRMC) and the Department of Defense Center Alliance for Dietary Supplements Research. NR 114 TC 17 Z9 18 U1 3 U2 21 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0029-6643 EI 1753-4887 J9 NUTR REV JI Nutr. Rev. PD FEB PY 2012 VL 70 IS 2 BP 107 EP 117 DI 10.1111/j.1753-4887.2011.00444.x PG 11 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 885KX UT WOS:000299779000004 PM 22300597 ER PT J AU McGee, JP AF McGee, Joseph Patrick TI The Laws of War, on the Ground SO POLICY REVIEW LA English DT Article C1 [McGee, Joseph Patrick] USA, Washington, DC USA. [McGee, Joseph Patrick] Hoover Inst War Revolut & Peace, Stanford, CA 94305 USA. RP McGee, JP (reprint author), 101st Airborne Div Air Assault, Brigade Combat Team 1, Ft Campbell, KY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU HOOVER INST PI STANFORD PA STANFORD UNIV, STANFORD, CA 94305-601 USA SN 0146-5945 J9 POLICY REV JI Policy Rev. PD FEB-MAR PY 2012 IS 171 BP 63 EP 72 PG 10 WC Political Science SC Government & Law GA 888BR UT WOS:000299979300005 ER PT J AU Griffith, J AF Griffith, James TI Suicide in the Army National Guard: An Empirical Inquiry SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; SOCIAL RELATIONSHIPS; MILITARY; HEALTH; DEPLOYMENT; SYMPTOMS; RATES; POPULATION; PREVENTION; EVENTS AB Since 2004, suicides in the U.S. military have risen, most notably in the Army National Guard (ARNG). Data used in this study were obtained for suicides occurring from 2007 to 2010 and for a random sample of nonsuicides from the general ARNG population. Of the military-related variables considered, a few showed relationships to suicide. Rather, the primary variables associated with suicide were soldier background characteristics, including age (1724 years), race (White), and gender (male). Cluster analysis revealed two distinct suicide groups: careerists (about one third of all suicides) and first-termers (about two thirds of all suicides), each group exhibiting different concurrent behavioral problems. C1 [Griffith, James] USA, Med Serv Corps, Natl Guard, Baltimore, MD USA. RP Griffith, J (reprint author), 10956 Bellehaven Blvd, Damascus, MD 20872 USA. EM griffithjh@verizon.net NR 60 TC 14 Z9 14 U1 2 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0363-0234 J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD FEB PY 2012 VL 42 IS 1 BP 104 EP 119 DI 10.1111/j.1943-278X.2011.00075.x PG 16 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 889AR UT WOS:000300046400009 PM 22288872 ER PT J AU Morris, MJ Christopher, KL AF Morris, Michael J. Christopher, Kent L. TI Difficult-to-Treat Asthma or Vocal Cord Dysfunction? SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Letter C1 [Morris, Michael J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Christopher, Kent L.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 7 TC 3 Z9 3 U1 0 U2 1 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD FEB 1 PY 2012 VL 185 IS 3 BP 340 EP 340 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 885TF UT WOS:000299803000018 PM 22298366 ER PT J AU Markelz, AE Mende, K Murray, CK Yu, X Zera, WC Hospenthal, DR Beckius, ML Calvano, T Akers, KS AF Markelz, Ana Elizabeth Mende, Katrin Murray, Clinton K. Yu, Xin Zera, Wendy C. Hospenthal, Duane R. Beckius, Miriam L. Calvano, Tatjana Akers, Kevin S. TI Carbapenem Susceptibility Testing Errors Using Three Automated Systems, Disk Diffusion, Etest, and Broth Microdilution and Carbapenem Resistance Genes in Isolates of Acinetobacter baumannii-calcoaceticus Complex (vol 55, pg 4707, 2011) SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Correction C1 [Markelz, Ana Elizabeth] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Infect Dis Clin Res Program, Bethesda, MD USA. RP Markelz, AE (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD FEB PY 2012 VL 56 IS 2 BP 1149 EP 1149 DI 10.1128/AAC.06045-11 PG 1 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 883TX UT WOS:000299658900085 ER PT J AU Perreault, NN Crocker, FH Indest, KJ Hawari, J AF Perreault, Nancy N. Crocker, Fiona H. Indest, Karl J. Hawari, Jalal TI Involvement of cytochrome c CymA in the anaerobic metabolism of RDX by Shewanella oneidensis MR-1 SO CANADIAN JOURNAL OF MICROBIOLOGY LA English DT Article DE RDX; explosive; nitramine; biotransformation; Shewanella ID SULFATE-REDUCING BACTERIA; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; ELECTRON-ACCEPTOR; SP-NOV.; BIODEGRADATION; REDUCTION; RESPIRATION; GENE; CLONING; HEXAHYDRO-1-NITROSO-3,5-DINITRO-1,3,5-TRIAZINE AB Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a cyclic nitramine explosive commonly used for military applications that is responsible for severe soil and groundwater contamination. In this study, Shewanella oneidensis MR-1 was shown to efficiently degrade RDX anaerobically (3.5 mu mol.h(-1).(g protein)(-1)) via two initial routes: (1) sequential N-NO2 reductions to the corresponding nitroso (N-NO) derivatives (94% of initial RDX degradation) and (2) denitration followed by ring cleavage. To identify genes involved in the anaerobic metabolism of RDX, a library of similar to 2500 mutants of MR-1 was constructed by random transposon mutagenesis and screened for mutants with a reduced ability to degrade RDX compared with the wild type. An RDX-defective mutant (C9) was isolated that had the transposon inserted in the c-type cytochrome gene cymA. C9 transformed RDX at similar to 10% of the wild-type rate, with degradation occurring mostly via early ring cleavage caused by initial denitration leading to the formation of methylenedinitramine, 4-nitro-2,4-diazabutanal, formaldehyde, nitrous oxide, and ammonia. Genetic complementation of mutant C9 restored the wild-type phenotype, providing evidence that electron transport components have a role in the anaerobic reduction of RDX by MR-1. C1 [Perreault, Nancy N.; Hawari, Jalal] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. [Crocker, Fiona H.; Indest, Karl J.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Hawari, J (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada. EM jalal.hawari@cnrc-nrc.gc.ca FU Strategic Environmental Research and Development Program (SERDP), USA [ER1609] FX This work was supported by the Strategic Environmental Research and Development Program (SERDP), USA (ER1609). We thank J.-S. Zhao and also A. Halasz, D. Manno, L. Paquet, A. Corriveau, and S. Deschamps for the analytic support and D. Labbe for help with the Southern blot. We thank Dr. Maria Brandl for kindly providing the pBBR1MCS-5 vector. NR 37 TC 6 Z9 6 U1 4 U2 14 PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS PI OTTAWA PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA SN 0008-4166 J9 CAN J MICROBIOL JI Can. J. Microbiol. PD FEB PY 2012 VL 58 IS 2 BP 124 EP 131 DI 10.1139/W11-116 PG 8 WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Immunology; Microbiology GA 885PO UT WOS:000299791500002 PM 22260206 ER PT J AU Molloy, JW Calcagno, CJ Williams, CD Jones, FJ Torres, DM Harrison, SA AF Molloy, Jeffrey W. Calcagno, Christopher J. Williams, Christopher D. Jones, Frances J. Torres, Dawn M. Harrison, Stephen A. TI Association of coffee and caffeine consumption with fatty liver disease, nonalcoholic steatohepatitis, and degree of hepatic fibrosis SO HEPATOLOGY LA English DT Article ID TERM-FOLLOW-UP; CIRRHOSIS; COMPONENTS; ENZYMES; PEROXIDATION; POPULATION; INHIBITION; PREVALENCE; MECHANISMS; CAFESTOL AB Coffee caffeine consumption (CC) is associated with reduced hepatic fibrosis in patients with chronic liver diseases, such as hepatitis C. The association of CC with nonalcoholic fatty liver disease (NAFLD) has not been established. The aim of this study was to correlate CC with the prevalence and severity of NAFLD. Patients involved in a previously published NAFLD prevalence study, as well as additional NASH patients identified in the Brooke Army Medical Center Hepatology clinic, were queried about their caffeine intake. A validated questionnaire for CC was utilized to assess for a relationship between caffeine and four groups: ultrasound negative (controls), bland steatosis/not-NASH, NASH stage 0-1, and NASH stage 2-4. A total of 306 patients responded to the CC questionnaire. Average milligrams of total caffeine/coffee CC per day in controls, bland steatosis/not-NASH, NASH stage 0-1, and NASH stage 2-4 were 307/228, 229/160, 351/255, and 252/152, respectively. When comparing patients with bland steatosis/not-NASH to those with NASH stage 0-1, there was a significant difference in CC between the two groups (P = 0.005). Additionally, when comparing patients with NASH stage 0-1 to those with NASH stage 2-4, there was a significant difference in coffee CC (P = 0.016). Spearman's rank correlation analysis further supported a negative relationship between coffee CC and hepatic fibrosis (r = -0.215; P = 0.035). Conclusion: Coffee CC is associated with a significant reduction in risk of fibrosis among NASH patients. (Hepatology 2012) C1 [Calcagno, Christopher J.; Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Molloy, Jeffrey W.; Williams, Christopher D.; Jones, Frances J.; Harrison, Stephen A.] Wilford Hall USAF Med Ctr, Div Gastroenterol & Hepatol, Lackland AFB, TX 78236 USA. [Torres, Dawn M.] Walter Reed Army Med Ctr, Div Gastroenterol & Hepatol, Bethesda, MD USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.Harrison@amedd.army.mil NR 32 TC 100 Z9 103 U1 1 U2 22 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD FEB PY 2012 VL 55 IS 2 BP 429 EP 436 DI 10.1002/hep.24731 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 883KM UT WOS:000299632900011 PM 21987293 ER PT J AU Klein, DA Gildengorin, G Mosher, P Adelman, WP AF Klein, David A. Gildengorin, Ginny Mosher, Peter Adelman, William P. TI Adolescent Caesarean Delivery in the US Military Health Care System SO JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY LA English DT Article DE Teenage; Adolescent; C-section; Caesarean delivery; Demographic; Military; Risk factors ID UNITED-STATES; SECTION; RATES AB Objectives: Determine cesarean delivery (CD) rates and associated demographics among military dependent teenagers. Methods: United States military health care claims records of live births from 2003-2006 to 13- through 19-year-old dependent children were analyzed using logistic regression. Results: The CD rate rose from 17% in 2003 to 20% in 2006. Rates were significantly higher for ages 18 and 19, for African American sponsors' children, and those who gave birth in a civilian facility. Rates did not differ significantly by sponsor's military rank. Conclusions: Teenagers in the military health care system have increasing rates of CD. Independent demographic risk factors for teenage CD include age > 17 years, sponsor's race African American, and delivery at a civilian facility. C1 [Klein, David A.] Lajes Air Base, Family Hlth Clin, Azores, Portugal. [Mosher, Peter] David Grant Med Ctr, TRICARE Operat, Travis Air Force Base, CA USA. [Adelman, William P.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Klein, DA (reprint author), 65 MDG Lajes Field Family Hlth Clin, Unit 7745, APO, AE 09720 USA. EM david.klein@lajes.af.mil NR 9 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1083-3188 EI 1873-4332 J9 J PEDIATR ADOL GYNEC JI J. Pediatr Adolesc. Gynecol. PD FEB PY 2012 VL 25 IS 1 BP 74 EP 76 DI 10.1016/j.jpag.2011.09.006 PG 3 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA 874PZ UT WOS:000298971900017 ER PT J AU Brechue, WF Mayhew, JL AF Brechue, William F. Mayhew, Jerry L. TI LOWER-BODY WORK CAPACITY AND ONE-REPETITION MAXIMUM SQUAT PREDICTION IN COLLEGE FOOTBALL PLAYERS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE off-season conditioning; performance evaluation; strength training; football ID MUSCULAR ENDURANCE REPETITIONS; BENCH PRESS; RESISTANCE EXERCISES; HIGH-INTENSITY; BLOOD-FLOW; STRENGTH; ADAPTATIONS; NUMBER; PERFORMANCE; EQUATIONS AB Brechue, WE and Mayhew, JL. Lower-body work capacity and 1RM squat prediction in college football players. J Strength Cond Res 26(2): 364-372, 2012 The purpose of this study was to assess lower-body muscular strength and work capacity after off-season resistance training and the efficacy of predicting maximal squat strength (1 repetition maximum [1RM]) from repetitions to fatigue. National Collegiate Athletic Association Division-II football players (n = 58) were divided into low-strength (LS, 1RM < 365 lb, n = 32) and high-strength (HS, 1RM >= 365 lb, n = 26) groups before training based on median 1RM squat performance. Maximal repetitions to failure (RTFs) were performed with a relative load of 70% of 1RM before training and 60, 70, 80, and 90% of 1RM after 12 weeks of a linear periodization resistance training program. As a team, 1RM squat (32 +/- 27 lb), 70% RTF (4.5 +/- 4.5 reps), and work capacity at 70% 1RM load (1,482 +/- 1,181 lb reps) increased significantly after training. Likewise, training resulted in significant increases in 1RM, RTF at 70% 1RM, and work capacity (load x reps) in both LS (8 +/- 33 lb, 3.9 +/- 4.7 reps, 1,736 +/- 1,521 lb reps, respectively) and HS (27 +/- 21 lb, 4.9 +/- 4.4 reps, 2,387 +/- 1,767 lb reps, respectively), with no significant difference between groups. There was no relationship between the change in work capacity and the change in muscular strength for either the LS (r = 0.02) or HS (r = 0.06) group. Predicted 1RMs were best when RTFs were performed using 80% 1RM (5-17 RTFs), with an error of +/- 5% in 95% of the subjects. In conclusion, the changes in muscular strength associated with an off-season training program appear to have a positive influence on squat work capacity at 70% of 1RM and allow favorable prediction of 1RM using submaximal loads. C1 [Brechue, William F.] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Mayhew, Jerry L.] Truman State Univ, Human Performance Lab, Kirksville, MO USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Dept Physiol, Kirksville, MO USA. RP Brechue, WF (reprint author), US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. EM bill.brechue@usma.edu NR 38 TC 3 Z9 4 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2012 VL 26 IS 2 BP 364 EP 372 PG 9 WC Sport Sciences SC Sport Sciences GA 886MD UT WOS:000299857600007 PM 22233793 ER PT J AU Knapik, JJ Harman, EA Steelman, RA Graham, BS AF Knapik, Joseph J. Harman, Everett A. Steelman, Ryan A. Graham, Bria S. TI A SYSTEMATIC REVIEW OF THE EFFECTS OF PHYSICAL TRAINING ON LOAD CARRIAGE PERFORMANCE SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Review DE meta-analysis; aerobic training; resistance training; intervals; periodization; plyometrics ID MATERIAL-HANDLING ABILITY; BRITISH-ARMY RECRUITS; FITNESS; RESISTANCE; SPECIFICITY; ADAPTATIONS; PROGRAM; TASK AB Knapik, JJ, Harman, EA, Steelman, RA, and Graham, BS. A systematic review of the effects of physical training on load carriage performance. I Strength Cond Res 26(2): 585-597, 2012 Soldiers are often required to carry heavy loads during military operations. This article reports on a systematic literature review examining the influence of physical training on load carriage performance. Several literature databases, reference lists, and other sources were explored to find studies that quantitatively examined the effects of physical training on the time taken for individuals to complete a set distance carrying an external load, with the majority of the load contained in a backpack. Effect sizes (Cohen's d statistic) were used in meta-analyses to examine the changes in load carriage performance after various modes of physical training. Effect sizes quantified training-related changes in terms of SD units. Ten original research studies met the review criteria. Meta-analysis indicated that large training effects (>= 0.8SD units) were apparent when progressive resistance training was combined with aerobic training and when that training was conducted at least 3 times per week, over at least 4 weeks. When progressive load-carriage exercise was part of the training program, much larger training effects were evident (summary effect size [SES] = 1.7SD units). Field-based training that combined a wide variety of training modes and included progressive load-carriage exercise was also very effective in improving load carriage performance (SES = 1.1SD units). Aerobic training alone or resistance training alone had smaller and more variable effects, depending on the study. This review indicates that combinations of specific modes of physical training can substantially improve load carriage performance. C1 [Knapik, Joseph J.; Steelman, Ryan A.; Graham, Bria S.] USA, Inst Publ Hlth Epidemiol & Dis Surveillance Portf, Aberdeen Proving Ground, MD USA. RP Knapik, JJ (reprint author), USA, Inst Publ Hlth Epidemiol & Dis Surveillance Portf, Aberdeen Proving Ground, MD USA. EM joseph.knapik@apg.amedd.army.mil NR 42 TC 26 Z9 26 U1 2 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2012 VL 26 IS 2 BP 585 EP 597 PG 13 WC Sport Sciences SC Sport Sciences GA 886MD UT WOS:000299857600036 PM 22130400 ER PT J AU Sikorski, C Emerson, MA Cowan, DN Niebuhr, DW AF Sikorski, Cynthia Emerson, Maura A. Cowan, David N. Niebuhr, David W. TI Risk Factors for Medical Disability in US Enlisted Marines: Fiscal Years 2001 to 2009 SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT Conference on Armed Forces Public Health CY MAR, 2011 CL Norfolk, VA ID MILITARY ENLISTEES; INJURY; ATTRITION; DISCHARGE; ARMY; DIAGNOSES AB Objective: To assess factors associated with medical disability in the U.S. Marine Corps. Methods: Case control study enrolling 11,554 medical disability cases of U.S. enlisted Marines referred to the Physical Evaluation Board fiscal year 2001 to 2009 and 42,216 controls frequency matched to cases in a 4:1 ratio on year of accession into the service were analyzed utilizing bivariate and multivariate logistic regression analysis. Results: Increased age and body mass index at accession were associated with higher odds of medical disability. Females (odds ratio adjusted [ORadJ] = 1.3, 95% confidence interval [CI] = 1.2-1.3) have higher odds of disability than males. "Healthy Warrior Effect" was observed in that those who deployed (ORadi = 0.48, 95% Cl = 0.46-0.50) had decreased odds of medical disability than those who did not deploy. Medical waivers at accession (ORadi = 1.12, 95% Cl = 1.01-1.23) increased the odds of medical disability. Conclusions: Continued surveillance of the disability evaluation system is needed to help develop preventive measures and to help policy makers establish evidence-based policies on accession, deployment, and retention standards over the lifecycle of service members. C1 [Sikorski, Cynthia] Uniformed Serv Univ Hlth Sci, Dept Prevent Med, Bethesda, MD 20814 USA. [Emerson, Maura A.] Secretary Navy Council Review Boards, Washington, DC 20374 USA. [Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD 20910 USA. [Cowan, David N.] Allied Technol Grp Inc, Rockville, MD 20850 USA. RP Sikorski, C (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 30 TC 14 Z9 14 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2012 VL 177 IS 2 BP 128 EP 134 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 886KC UT WOS:000299852300003 PM 22360055 ER PT J AU Coldren, RL Russell, ML Parish, RV Dretsch, M Kelly, MP AF Coldren, Rodney L. Russell, Michael L. Parish, Robert V. Dretsch, Michael Kelly, Mark P. TI The ANAM Lacks Utility as a Diagnostic or Screening Tool for Concussion More Than 10 Days Following Injury SO MILITARY MEDICINE LA English DT Article ID TRAUMATIC BRAIN-INJURY; NEUROPSYCHOLOGICAL ASSESSMENT METRICS; RECOVERY; IRAQ; DEPLOYMENT; PERSONNEL; FOOTBALL; OUTCOMES; TIME AB Congress has mandated that the Department of Defense perform screening for concussion. or mild traumatic brain injury, on all service members redeploying from Iraq and Afghanistan. However, the retrospective diagnosis of concussion is complicated by the subjective nature of the complaints, overlap of symptoms with other conditions, and the normally rapid recovery of neurocognitive function following a concussive event. One diagnostic and screening test in current use by the Department of Defense is the Automated Neuropsychological Assessment Metrics (ANAM). A team of researchers deployed to Iraq between January and April 2009 to test the validity of the ANA M for the diagnosis of concussion in the combat environment. Performance by concussed participants on all six ANAM subtests was compared with that of controls. The ANAM appears to have no utility as an individual diagnostic or population screening tool for the detection of neurocognitive dysfunction from a single. uncomplicated concussion when administered 10 or more days following injury. Further studies are required to determine the modalities providing optimal sensitivity and specificity for use as diagnostic or screening tests beyond the first 72-hour acute postinjury period. C1 [Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Russell, Michael L.] Lincoln Ctr, Off Surgeon Gen, R2D, San Antonio, TX 78230 USA. [Parish, Robert V.] CMR, Landstuhl Reg Med Ctr, APO, AE 09180 USA. [Dretsch, Michael] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Kelly, Mark P.] Walter Reed Army Med Ctr, Dept Psychol, Washington, DC USA. RP Coldren, RL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. FU U.S. Army Medical Research Acquisition Activity, Fort Detrick, Maryland; [W81XWH-09-2-0057] FX Sponsor of this award is provided by The U.S. Army Medical Research Acquisition Activity, Fort Detrick, Maryland and is the awarding and administering acquisition office. Material provided in this presentation under award W81XWH-09-2-0057 does not necessarily reflect the position or the policy of the Government, and no of endorsement should be interred. The views expressed in this letter are those of the authors and do not reflect the official policy of the Department of Army. Department of Defense. or U.S. Government. NR 19 TC 25 Z9 25 U1 1 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2012 VL 177 IS 2 BP 179 EP 183 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 886KC UT WOS:000299852300012 PM 22360064 ER PT J AU Zhang, BX Wear, DJ Kim, HS Weina, P Stojadinovic, A Izadjoo, M AF Zhang, Binxue Wear, Douglas J. Kim, H. S. Weina, Peter Stojadinovic, Alexander Izadjoo, Mina TI Development of Hydrolysis Probe-Based Real-Time PCR for Identification of Virulent Gene Targets of Burkholderia pseudomallei and B. mallei-A Retrospective Study on Archival Cases of Service Members with Melioidosis and Glanders SO MILITARY MEDICINE LA English DT Article ID III SECRETION SYSTEM; SUBTRACTIVE HYBRIDIZATION; POLYSACCHARIDE; THAILANDENSIS; DETERMINANT; CLUSTER AB Burkholderia pseudomallei and B. mallei are two highly pathogenic bacteria responsible for melioidosis and glanders, respectively. Our laboratory developed hydrolysis probe-based real-time polymerase chain reaction assays targeting type three secretion system (TTS) and transposase family protein (TFP) of B. pseudomallei and B. malli, respectively. The assays were validated for target specificity, amplification sensitivity, and reproducibility. A bacterial DNA panel, composed of B. pseudomallei (13 strains), B. mallei (11 strains), Burkholderia species close neighbors (5 strains), and other bacterial species (17 strains), was prepared for specificity testing. Reference DNAs from B. pseudomallei and B. mallei bacterial cultures were used as controls for amplification, limit of detection, and reproducibility testing. The two TaqMan assays, Bp-TTS1 and Bm-TFP, were optimized and applied in a retrospective study of archived cases from the Armed Forces Institute of Pathology. We tested 10 formalin-fixed paraffin-embedded blocks originally from autopsy specimens of patients who died of melioidosis or glanders during or after overseas tours in 1960s. Polymerase chain reaction results confirmed that DNA samples from formalin-fixed paraffin-embedded blocks of eight patients with melioidosis were positive for Bp-TTS1 target and two patients with glanders were positive for Bm-TFP target. C1 [Zhang, Binxue; Kim, H. S.; Izadjoo, Mina] Henry M Jackson Fdn, Gaithersburg, MD 20879 USA. [Wear, Douglas J.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Weina, Peter] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Zhang, BX (reprint author), Henry M Jackson Fdn, 401 Profess Dr, Gaithersburg, MD 20879 USA. RI Weina, Peter/A-2120-2011 FU Federal Consultation Services FX We thank Mr. Jose Rodriguez for processing all FFPE blocks in preparation for this study. This study was funded by Federal Consultation Services provided to Armed Forces Institute of Pathology. NR 21 TC 5 Z9 5 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2012 VL 177 IS 2 BP 216 EP 221 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 886KC UT WOS:000299852300018 PM 22360070 ER PT J AU Zhang, ML Wu, WM Lin, LH Yu, JN AF Zhang MingLiang Wu WeiMing Lin LiHua Yu JiangNan TI Coupling of wave and current numerical model with unstructured quadtree grid for nearshore coastal waters SO SCIENCE CHINA-TECHNOLOGICAL SCIENCES LA English DT Article DE wave-current interaction; unstructured quadtree grid; finite volume method; HLL approximate Riemann solver; wave action spectral model ID FINITE-VOLUME METHOD; DAM-BREAK FLOWS; TRANSFORMATION MODEL; SIMULATION; CHANNELS; SCHEME AB This paper presents 2D wave-current interaction model for evaluating nearly horizontal wave-induced currents in the surf-zone and coastal waters. The hydrodynamic model is the two-dimensional depth-averaged nonlinear shallow water equations by using an unstructured non-staggered and multiple-level quadtree rectangular mesh, this mesh information is stored in simple data structures and it is easy to obtain a locally high resolution for important region. The intercell fluxes are computed based on the HLL (Harten-Lax-van Leer) approximate Riemann solver with shock capturing capability for computing the dry-to-wet interface of coastal line. The effects of pressure and gravity are included in source term in the model, this treatment can simplify the computation and eliminate numerical imbalance between source and flux terms. The wave model readily provides the radiation stresses that represent the shortwave-averaged forces in a water column for the hydrodynamic model and the wave model takes into account the effect of wave-induced nearshore currents and water level. The coupling model is applied to verify different experimental cases and real life case of considering the wave-current interaction. The calculated results agree with analytical solution, experimental and field data. The results show that the modeling approach presented herein should be useful in simulating the nearshore processes in complicated natural coastal domains. C1 [Zhang MingLiang; Yu JiangNan] Dalian Ocean Univ, Sch Ocean Technol & Environm, Dalian 116023, Peoples R China. [Wu WeiMing] Univ Mississippi, Natl Ctr Computat Hydrosci & Engn, University, MS 38677 USA. [Lin LiHua] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Zhang, ML (reprint author), Dalian Ocean Univ, Sch Ocean Technol & Environm, Dalian 116023, Peoples R China. EM zhmliang_mail@126.com FU National Natural Science Foundation of China [50839001]; Southeast Regional Research Initiative (SERRI) [80037]; ERDC, US Army Corps of Engineers, Vicksburg, MS, USA FX This work was supported by the National Natural Science Foundation of China (Grant No. 50839001), the research grant from Southeast Regional Research Initiative (SERRI, 80037) and the Coastal Inlets Research Program, ERDC, US Army Corps of Engineers, Vicksburg, MS, USA. NR 32 TC 6 Z9 6 U1 1 U2 15 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1674-7321 EI 1869-1900 J9 SCI CHINA TECHNOL SC JI Sci. China-Technol. Sci. PD FEB PY 2012 VL 55 IS 2 BP 568 EP 580 DI 10.1007/s11431-011-4643-2 PG 13 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 877JN UT WOS:000299175100028 ER PT J AU O'Connor, SC Rooks, VJ Smith, AB AF O'Connor, Stephen C. Rooks, Veronica J. Smith, Alice Boyd TI Magnetic Resonance Imaging of the Fetal Central Nervous System, Head, Neck, and Chest SO SEMINARS IN ULTRASOUND CT AND MRI LA English DT Article ID CONGENITAL DIAPHRAGMATIC-HERNIA; INCREASINGLY IMPORTANT TOOL; PRENATAL-DIAGNOSIS; SACROCOCCYGEAL TERATOMA; FETUSES; MRI; ANOMALIES; SPINE; ABNORMALITIES; EXPERIENCE C1 [O'Connor, Stephen C.] Tufts Univ, Baystate Med Ctr, Dept Radiol, Sch Med, Springfield, MA 01199 USA. [Rooks, Veronica J.; Smith, Alice Boyd] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. [Rooks, Veronica J.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. RP O'Connor, SC (reprint author), Tufts Univ, Baystate Med Ctr, Dept Radiol, Sch Med, 759 Chestnut St, Springfield, MA 01199 USA. EM Stephen.o'connor@bhs.org NR 46 TC 8 Z9 9 U1 3 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0887-2171 EI 1558-5034 J9 SEMIN ULTRASOUND CT JI Semin. Ultrasound CT MRI PD FEB PY 2012 VL 33 IS 1 BP 86 EP 101 DI 10.1053/j.sult.2011.10.005 PG 16 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 886JK UT WOS:000299850500011 PM 22264906 ER PT J AU Costante, M Biggemann, L Alamneh, Y Soojhawon, I Short, R Nigam, S Garcia, G Doctor, BP Valiyaveettil, M Nambiar, MP AF Costante, Michael Biggemann, Lionel Alamneh, Yonas Soojhawon, Iswarduth Short, Radley Nigam, Savita Garcia, Gregory Doctor, Bhupendra P. Valiyaveettil, Manojkumar Nambiar, Madhusoodana P. TI Hydrolysis potential of recombinant human skin and kidney prolidase against. diisopropylfluorophosphate and sarin by in vitro analysis SO TOXICOLOGY IN VITRO LA English DT Article DE Catalytic bioscavenger; Prolidase; Organophosphates; Recombinant protein; Nerve agents; Chemical threat ID ORGANOPHOSPHORUS NERVE AGENTS; HUMAN LIVER PROLIDASE; SACCHAROMYCES-CEREVISIAE; NUCLEOTIDE-SEQUENCE; DUAL ACTIVITIES; MESSENGER-RNA; DEFICIENCY; ENZYME; GENE; PURIFICATION AB Human prolidase (PROL), which has structural homology to bacterial organophosphate acid anhydrolase that hydrolyze organophosphates and nerve agents has been proposed recently as a potential catalytic bioscavenger. To develop PROL as a catalytic bioscavenger, we evaluated the in vitro hydrolysis efficiency of purified recombinant human PROL against organophosphates and nerve agents. Human liver PROL was purified by chromatographic procedures, whereas recombinant human skin and kidney PROL was expressed in Trichoplusia ni larvae, affinity purified and analyzed by gel electrophoresis. The catalytic efficiency of PROL against diisopropylfluorophosphate (DFP) and nerve agents was evaluated by acetylcholinesterase back-titration assay. Partially purified human liver PROL hydrolyzed DEP and various nerve agents, which was abolished by specific PROL inhibitor showing the specificity of hydrolysis. Both the recombinant human skin and kidney PROL expressed in T. ni larvae showed similar to 99% purity and efficiently hydrolyzed DEP and sarin. In contrast to human liver PROL, both skin and kidney PROL showed significantly low hydrolyzing potential against nerve agents soman, tabun and VX. In conclusion, compared to human liver PROL recombinant human skin and kidney PROL hydrolyze only DEP and sarin showing the substrate specificity of PROL from various tissue sources. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Costante, Michael; Biggemann, Lionel; Alamneh, Yonas; Soojhawon, Iswarduth; Doctor, Bhupendra P.; Valiyaveettil, Manojkumar; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. [Short, Radley; Nigam, Savita; Garcia, Gregory] Walter Reed Army Inst Res, Dept Biochem, Silver Spring, MD 20910 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM m.valiyaveettil@amedd.army.mil; madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [1.D0022_07_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant 1.D0022_07_WR_C. The collaborative help from Dr. Alfred M. Sciuto, Dr. Michael W. Perkins, Dr. Praveena Sabnekar, Peter Rezk and Zdenka Pierre from USAMRICD is greatly acknowledged. We also thank Robert Balcerzak and his team from Chesapeake PERL for the expression and purification of recombinant PROL. NR 35 TC 7 Z9 9 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD FEB PY 2012 VL 26 IS 1 BP 182 EP 188 DI 10.1016/j.tiv.2011.11.006 PG 7 WC Toxicology SC Toxicology GA 884MV UT WOS:000299713100024 PM 22120822 ER PT J AU Paisley, RD Blaylock, J Hartzell, JD AF Paisley, Robert D. Blaylock, Jason Hartzell, Joshua D. TI Whooping Cough in Adults: An Update on a Reemerging Infection SO AMERICAN JOURNAL OF MEDICINE LA English DT Article DE Pertussis; Tdap; Whooping cough ID PERTUSSIS; ADOLESCENT; VACCINE AB Pertussis, or whooping cough, which is commonly thought of as a pediatric illness, is an underappreciated adult pathogen. Recent outbreaks highlight the significance of pertussis in adults and the risk of transmission to at-risk infants who are most susceptible to complications, including death. This article describes the recent epidemiologic shifts and reviews the clinical presentation, diagnosis, and treatment of pertussis. New vaccination recommendations by the Advisory Committee on Immunization Practices in response to recent outbreaks and infant deaths are highlighted. Published by Elsevier Inc. (C) The American Journal of Medicine (2012) 125, 141-143 C1 [Paisley, Robert D.; Blaylock, Jason; Hartzell, Joshua D.] USA, Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Blaylock, Jason; Hartzell, Joshua D.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Paisley, RD (reprint author), USA, Walter Reed Army Med Ctr, Dept Med, BLD 2,Ward 74,6900 Georgia Ave NW, Washington, DC 20307 USA. EM robert.paisley1@us.army.mil NR 7 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9343 J9 AM J MED JI Am. J. Med. PD FEB PY 2012 VL 125 IS 2 BP 141 EP 143 DI 10.1016/j.amjmed.2011.05.008 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 881ZU UT WOS:000299531700015 PM 22269615 ER PT J AU Enewold, L Zhou, J McGlynn, KA Anderson, WF Shriver, CD Potter, JF Zahm, SH Zhu, KM AF Enewold, Lindsey Zhou, Jing McGlynn, Katherine A. Anderson, William F. Shriver, Craig D. Potter, John F. Zahm, Shelia H. Zhu, Kangmin TI Racial variation in breast cancer treatment among Department of Defense beneficiaries SO CANCER LA English DT Article ID AFRICAN-AMERICAN PATIENTS; BLACK-AND-WHITE; DISPARITIES; CARE; WOMEN; CARCINOMA; MORTALITY; OPPORTUNITIES; CHEMOTHERAPY; POPULATION AB BACKGROUND: Although the overall age-adjusted incidence rates for female breast cancer are higher among whites than blacks, mortality rates are higher among blacks. Many attribute this discrepancy to disparities in health care access and to blacks presenting with later stage disease. Within the Department of Defense (DoD) Military Health System, all beneficiaries have equal access to health care. The aim of this study was to determine whether female breast cancer treatment varied between white and black patients in the DoD system. METHODS: The study data were drawn from the DoD cancer registry and medical claims databases. Study subjects included 2308 white and 391 black women diagnosed with breast cancer between 1998 and 2000. Multivariate logistic regression analyses that controlled for demographic factors, tumor characteristics, and comorbidities were used to assess racial differences in the receipt of surgery, chemotherapy, and hormonal therapy. RESULTS: There was no significant difference in surgery type, particularly when mastectomy was compared with breast-conserving surgery plus radiation (blacks vs whites: odds ratio [OR], 1.1; 95% confidence interval [CI], 0.8-1.5). Among those with local stage tumors, blacks were as likely as whites to receive chemotherapy (OR, 1.2; 95% CI, 0.9-1.7) and hormonal therapy (OR, 1.0; 95% CI, 0.6-1.4). Among those with regional stage tumors, blacks were significantly less likely than whites to receive chemotherapy (OR, 0.4; 95% CI, 0.2-0.7) and hormonal therapy (OR, 0.5; 95% CI, 0.3-0.8). CONCLUSIONS: Even within an equal access health care system, stage-related racial variations in breast cancer treatment are evident. Studies that identify driving factors behind these within-stage racial disparities are warranted. Cancer 2012; 118: 812-20. (C) 2011 American Cancer Society. C1 [Enewold, Lindsey; Zhou, Jing; Shriver, Craig D.; Potter, John F.; Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [McGlynn, Katherine A.; Anderson, William F.; Zahm, Shelia H.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Shriver, Craig D.] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Potter, John F.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. RP Enewold, L (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Bldg 1,Suite E-111,6900 Georgia Ave, Washington, DC 20307 USA. EM Lindsey.Enewold@us.army.mil RI Zahm, Shelia/B-5025-2015 FU United States Military Cancer Institute (USMCI) via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine; Walter Reed Army Medical Center; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health FX Supported by the United States Military Cancer Institute (USMCI) via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine; the Clinical Breast Care Project, Walter Reed Army Medical Center; and the Intramural Research Program of the Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, National Institutes of Health. The original data linkage was supported by the USMCI and DCEG. NR 29 TC 12 Z9 12 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD FEB 1 PY 2012 VL 118 IS 3 BP 812 EP 820 DI 10.1002/cncr.26346 PG 9 WC Oncology SC Oncology GA 879NB UT WOS:000299335500027 PM 21766298 ER PT J AU Trang, NV Luan, LT Kim-Anh, LT Hau, VT Nhung, LT Phasuk, P Setrabutr, O Shirley, H Vinje, J Anh, DD Mason, CJ AF Trang, Nguyen V. Luan, Le T. Kim-Anh, Le T. Hau, Vu T. B. Nhung, Le T. H. Phasuk, Pimmnapar Setrabutr, Orntipa Shirley, Hannah Vinje, Jan Anh, Dang D. Mason, Carl J. TI Detection and molecular characterization of noroviruses and sapoviruses in children admitted to hospital with acute gastroenteritis in Vietnam SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE norovirus; sapovirus; children; gastroenteritis; Vietnam ID REVERSE TRANSCRIPTION-PCR; NORWALK-LIKE VIRUSES; CHI-MINH-CITY; GENETIC DIVERSITY; ASYMPTOMATIC INFECTIONS; HUMAN CALICIVIRUSES; ROTAVIRUS DIARRHEA; SOUTH-KOREA; INFANTS; THAILAND AB Noroviruses (NoV) and sapoviruses (SaV) are recognized as important causes of acute gastroenteritis in children worldwide. In this study, the prevalence and genetic variability of NoV and SaV were determined in hospitalized children < 5 years of age with acute gastroenteritis in Hanoi, Vietnam. A total of 501 fecal specimens collected between November-2007 and October-2008, that previously had been tested for rotavirus (RV), were tested for NoV and SaV by realtime RT-PCR. Positive samples were genotyped by conventional RT-PCR followed by sequencing. GII NoV was detected in 180 (36%) and SaV in 7 (1.4%) of the samples. NoV was detected year-round ranging from 9.5% in April to 81.5% in September among RV negative samples. NoV GII.4 Minerva (2006b) was the dominant genotype (93%) with a few other genotypes detected including GII.3 (4.4%), GII.13 (1.7%), and GII.2 (0.6%) but no GI strains. Only GI and GII SaV strains were detected in this study. No difference in NoV prevalence between age groups was noted. Frequency of vomiting or fever was similar between children with NoV and RV infection, yet, NoV caused diarrhea with longer duration. In conclusion, NoV is the second most frequent cause of diarrhea in hospitalized children in North Vietnam. J. Med. Virol. 84:290-297, 2012. (C) 2011 Wiley Periodicals, Inc. C1 [Trang, Nguyen V.; Kim-Anh, Le T.; Hau, Vu T. B.; Nhung, Le T. H.; Anh, Dang D.] Natl Inst Hyg & Epidemiol, Dept Immunol & Mol Biol, Hanoi, Vietnam. [Luan, Le T.] Ctr Res & Prod Vaccines & Biol, Hanoi, Vietnam. [Phasuk, Pimmnapar; Setrabutr, Orntipa; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Shirley, Hannah; Vinje, Jan] Ctr Dis Control & Prevent, Atlanta, GA USA. RP Anh, DD (reprint author), Natl Inst Hyg & Epidemiol, Dept Immunol & Mol Biol, Hanoi, Vietnam. EM ducanhnihe@hn.vnn.vn; carl.mason@afrims.org RI Valle, Ruben/A-7512-2013; OI Vinje, Jan/0000-0002-1530-3675; MASON, CARL/0000-0002-3676-2811 FU Vietnam National Foundation for Science and Technology Development [106.99.182.09]; AFRIMS; CDC, Atlanta FX Grant sponsor: The Vietnam National Foundation for Science and Technology Development (partial; PI Dang Duc Anh); Grant number: 106.99.182.09; Grant sponsor: AFRIMS and CDC, Atlanta. NR 51 TC 14 Z9 14 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD FEB PY 2012 VL 84 IS 2 BP 290 EP 297 DI 10.1002/jmv.23185 PG 8 WC Virology SC Virology GA 861ZQ UT WOS:000298060000016 PM 22170550 ER PT J AU Armstrong, LE Ganio, MS Casa, DJ Lee, EC McDermott, BP Klau, JF Jimenez, L Le Bellego, L Chevillotte, E Lieberman, HR AF Armstrong, Lawrence E. Ganio, Matthew S. Casa, Douglas J. Lee, Elaine C. McDermott, Brendon P. Klau, Jennifer F. Jimenez, Liliana Le Bellego, Laurent Chevillotte, Emmanuel Lieberman, Harris R. TI Mild Dehydration Affects Mood in Healthy Young Women SO JOURNAL OF NUTRITION LA English DT Article ID COGNITIVE PERFORMANCE; HEAT-STRESS; ENVIRONMENTAL-STRESS; MENTAL PERFORMANCE; VISUAL VIGILANCE; HYDRATION STATUS; SLEEP LOSS; DECREMENTS; EXERCISE; IMPAIRS AB Limited information is available regarding the effects of mild dehydration on cognitive function. Therefore, mild dehydration was produced by intermittent moderate exercise without hyperthermia and its effects on cognitive function of women were investigated. Twenty-five females (age 23.0 +/- 0.6 y) participated in three 8-h, placebo-controlled experiments involving a different hydration state each day: exercise-induced dehydration with no diuretic (DN), exercise-induced dehydration plus diuretic (DD; furosemide, 40 mg), and euhydration (EU). Cognitive performance, mood, and symptoms of dehydration were assessed during each experiment, 3 times at rest and during each of 3 exercise sessions. The DN and DD trials in which a volunteer attained a >= 1% level of dehydration were pooled and compared to that volunteer's equivalent EU trials. Mean dehydration achieved during these DN and DD trials was -1.36 +/- 0.16% of body mass. Significant adverse effects of dehydration were present at rest and during exercise for vigor-activity, fatigue-inertia, and total mood disturbance scores of the Profile of Mood States and for task difficulty, concentration, and headache as assessed by questionnaire. Most aspects of cognitive performance were not affected by dehydration. Serum osmolality, a marker of hydration, was greater in the mean of the dehydrated trials in which a >= 1% level of dehydration was achieved (P = 0.006) compared to EU. In conclusion, degraded mood, increased perception of task difficulty, lower concentration, and headache symptoms resulted from 1.36% dehydration in females. Increased emphasis on optimal hydration is warranted, especially during and after moderate exercise. J. Nutr. 142: 382-388, 2012. C1 [Lieberman, Harris R.] USA, Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. [Armstrong, Lawrence E.; Ganio, Matthew S.; Casa, Douglas J.; Lee, Elaine C.; McDermott, Brendon P.; Klau, Jennifer F.] Univ Connecticut, Human Performance Lab, Storrs, CT USA. [Ganio, Matthew S.] Univ Arkansas, Dept Hlth Human Performance & Recreat, Fayetteville, AR 72701 USA. [Jimenez, Liliana; Le Bellego, Laurent; Chevillotte, Emmanuel] Danone Res, R&D Waters, Palaiseau, France. RP Lieberman, HR (reprint author), USA, Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil FU Danone Research, Palaiseau, France FX Supported by Danone Research, Palaiseau, France. NR 38 TC 44 Z9 47 U1 0 U2 22 PU AMER SOC NUTRITION-ASN PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-3166 J9 J NUTR JI J. Nutr. PD FEB PY 2012 VL 142 IS 2 BP 382 EP 388 DI 10.3945/jn.111.142000 PG 7 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 880LN UT WOS:000299408700027 PM 22190027 ER PT J AU Harris, KD Deyle, GD Gill, NW Howes, RR AF Harris, Kevin D. Deyle, Gail D. Gill, Norman W. Howes, Robert R. TI Manual Physical Therapy for Injection-Confirmed Nonacute Acromioclavicular Joint Pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE distal clavicle excision; manipulation; mobilization; Mumford; shoulder ID DISTAL CLAVICLE RESECTION; RANDOMIZED CLINICAL-TRIAL; SHOULDER IMPINGEMENT SYNDROME; DISABILITY INDEX; GLENOHUMERAL JOINT; NECK PAIN; EXERCISE; OSTEOARTHRITIS; MANIPULATION; MANAGEMENT AB STUDY DESIGN: Prospective single-cohort study. OBJECTIVES: To determine and document changes in pain and disability in patients with primary, nonacute acromioclavicular joint (ACJ) pain treated with a manual therapy approach. BACKGROUND: To our knowledge, there are no published studies on the physical therapy management of nonacute ACJ pain. Manual physical therapy has been successful in the treatment of other shoulder conditions. METHODS: The chief inclusion criterion was greater than 50% pain relief with an ACJ diagnostic injection. Patients were excluded if they had sustained an ACJ injury within the previous 12 months. Treatment was conducted utilizing a manual physical therapy approach that addressed all associated impairments in the shoulder girdle and cervicothoracic spine. The primary outcome measure was the Shoulder Pain and Disability Index. Secondary measures were the American Shoulder and Elbow Surgeon and global rating of change scales. Outcomes were collected at baseline, 4 weeks, and 6 months. The Shoulder Pain and Disability Index and American Shoulder and Elbow Surgeon scale values were analyzed with a repeated-measures analysis of variance. RESULTS: thirteen patients (11 male; mean +/- SD age, 41.1 +/- 9.6 years) completed treatment consisting of an average of 6.4 sessions. Compared to baseline, there was a statistically significant and clinically meaningful improvement for the Shoulder Pain and Disability Index at 4 weeks (P = .001; mean, 25.9 points; 95% confidence interval [CI]: 11.9, 39.8) and 6 months (P<.001; mean, 29.8 points; 95% CI: 16.5, 43.0), and the American Shoulder and Elbow Surgeon scale at 4 weeks (P<.001; mean, 27.9 points; 95% CI: 14.7, 41.1) and 6 months (P<.001; mean, 32.6 points; 95% CI: 21.2, 43.9). CONCLUSION: Statistically significant and clinically meaningful improvements were observed in all outcome measures at 4 weeks and 6 months, following a short series of manual therapy interventions. These results, in a small cohort of patients, suggest the efficacy of this treatment approach but need to be verified by a randomized controlled trial. C1 [Harris, Kevin D.; Deyle, Gail D.; Gill, Norman W.] Brooke Army Med Ctr, Phys Therapy Serv, Ft Sam Houston, TX 78234 USA. [Howes, Robert R.] Brooke Army Med Ctr, Orthoped Serv, Ft Sam Houston, TX 78234 USA. [Deyle, Gail D.] Baylor Univ, Grad Sch, Waco, TX 76798 USA. RP Harris, KD (reprint author), Ft Sam Houston Primary Hlth Clin, Phys Therapy Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM kevin.65b.harris@gmail.com NR 69 TC 4 Z9 4 U1 1 U2 11 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD FEB PY 2012 VL 42 IS 2 BP 66 EP 80 DI 10.2519/jospt.2012.3866 PG 15 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 882VX UT WOS:000299593100003 PM 22030329 ER PT J AU Ryan, KL Rickards, CA Hinojosa-Laborde, C Cooke, WH Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Hinojosa-Laborde, Carmen Cooke, William H. Convertino, Victor A. TI Extracting autonomic information from oscillations in MSNA Reply from K. L. Ryan, C. A. Rickards, C. Hinojosa-Laborde, W. H. Cooke and V. A. Convertino SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Letter ID SYMPATHETIC-NERVE ACTIVITY; BLOOD-PRESSURE; SPECTRUM ANALYSIS; VARIABILITY C1 [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.; Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM kathy.ryan@amedd.army.mil NR 11 TC 0 Z9 0 U1 0 U2 3 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PD FEB PY 2012 VL 590 IS 3 BP 649 EP 650 DI 10.1113/jphysiol.2011.224667 PG 2 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA 883FK UT WOS:000299619400022 ER PT J AU Weddle, KJ AF Weddle, Kevin J. TI Confederate Generals in the Western Theater, vol 1, Classic Essays on America's Civil War, vol 2, Essays on America's Civil War SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 [Weddle, Kevin J.] USA, War Coll, Washington, DC USA. RP Weddle, KJ (reprint author), USA, War Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD FEB PY 2012 VL 78 IS 1 BP 178 EP 180 PG 3 WC History SC History GA 882VY UT WOS:000299593200037 ER PT J AU Lambrechts, L Fansiri, T Pongsiri, A Thaisomboonsuk, B Klungthong, C Richardson, JH Ponlawat, A Jarman, RG Scott, TW AF Lambrechts, Louis Fansiri, Thanyalak Pongsiri, Arissara Thaisomboonsuk, Butsaya Klungthong, Chonticha Richardson, Jason H. Ponlawat, Alongkot Jarman, Richard G. Scott, Thomas W. TI Dengue-1 Virus Clade Replacement in Thailand Associated with Enhanced Mosquito Transmission SO JOURNAL OF VIROLOGY LA English DT Article ID PRIMARY-SCHOOL CHILDREN; LINEAGE REPLACEMENT; KAMPHAENG-PHET; AEDES-AEGYPTI; PUERTO-RICO; SELECTION; MICROEVOLUTION; EMERGENCE; EVOLUTION; STRAINS AB Dengue viruses (DENV) are characterized by extensive genetic diversity and can be organized in multiple, genetically distinct lineages that arise and die out on a regular basis in regions where dengue is endemic. A fundamental question for understanding DENV evolution is the relative extent to which stochastic processes (genetic drift) and natural selection acting on fitness differences among lineages contribute to lineage diversity and turnover. Here, we used a set of recently collected and archived low-passage DENV-1 isolates from Thailand to examine the role of mosquito vector-virus interactions in DENV evolution. By comparing the ability of 23 viruses isolated on different dates between 1985 and 2009 to be transmitted by a present-day Aedes aegypti population from Thailand, we found that a major clade replacement event in the mid-1990s was associated with virus isolates exhibiting increased titers in the vector's hemocoel, which is predicted to result in a higher probability of transmission. This finding is consistent with the hypothesis that selection for enhanced transmission by mosquitoes is a possible mechanism underlying major DENV clade replacement events. There was significant variation in transmission potential among isolates within each clade, indicating that in addition to vector-driven selection, other evolutionary forces act to maintain viral genetic diversity. We conclude that occasional adaptive processes involving the mosquito vector can drive major DENV lineage replacement events. C1 [Fansiri, Thanyalak; Pongsiri, Arissara; Richardson, Jason H.; Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Lambrechts, Louis; Fansiri, Thanyalak] Inst Pasteur, Dept Virol, Paris, France. [Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Scott, Thomas W.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA. [Scott, Thomas W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. RP Lambrechts, L (reprint author), Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. EM louis.lambrechts@pasteur.fr RI Lambrechts, Louis/A-2057-2010; Richardson, Jason/A-9441-2011 OI Lambrechts, Louis/0000-0001-5958-2138; FU National Institutes of Health [R01 GM-083224]; French Agence Nationale de la Recherche [ANR-09-RPDOC-007-01]; Science and Technology Directorate, Department of Homeland Security, and Fogarty International Center, National Institutes of Health FX This study was primarily supported by grant R01 GM-083224 from the National Institutes of Health. L. L. was supported by grant ANR-09-RPDOC-007-01 from the French Agence Nationale de la Recherche. T. W. S. received support from the Research and Policy for Infectious Disease Dynamics Program of the Science and Technology Directorate, Department of Homeland Security, and Fogarty International Center, National Institutes of Health. NR 48 TC 41 Z9 42 U1 0 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD FEB PY 2012 VL 86 IS 3 BP 1853 EP 1861 DI 10.1128/JVI.06458-11 PG 9 WC Virology SC Virology GA 879CT UT WOS:000299308000051 PM 22130539 ER PT J AU Guo, BF Nixon, MS Damarla, T AF Guo, Baofeng Nixon, Mark S. Damarla, Thyagaraju TI Improving acoustic vehicle classification by information fusion SO PATTERN ANALYSIS AND APPLICATIONS LA English DT Article DE Pattern classification; Bayesian decision fusion; Information fusion ID SENSOR NETWORKS; RECOGNITION; SIGNATURE; SOUNDS; LEVEL AB We present an information fusion approach for ground vehicle classification based on the emitted acoustic signal. Many acoustic factors can contribute to the classification accuracy of working ground vehicles. Classification relying on a single feature set may lose some useful information if its underlying sound production model is not comprehensive. To improve classification accuracy, we consider an information fusion diagram, in which various aspects of an acoustic signature are taken into account and emphasized separately by two different feature extraction methods. The first set of features aims to represent internal sound production, and a number of harmonic components are extracted to characterize the factors related to the vehicle's resonance. The second set of features is extracted based on a computationally effective discriminatory analysis, and a group of key frequency components are selected by mutual information, accounting for the sound production from the vehicle's exterior parts. In correspondence with this structure, we further put forward a modified Bayesian fusion algorithm, which takes advantage of matching each specific feature set with its favored classifier. To assess the proposed approach, experiments are carried out based on a data set containing acoustic signals from different types of vehicles. Results indicate that the fusion approach can effectively increase classification accuracy compared to that achieved using each individual features set alone. The Bayesian-based decision level fusion is found to be improved than a feature level fusion approach. C1 [Guo, Baofeng] Hangzhou Dianzi Univ, Sch Automat, Hangzhou 310018, Zhejiang, Peoples R China. [Nixon, Mark S.] Univ Southampton, Sch Elect & Comp Sci, Southampton SO17 1BJ, Hants, England. [Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Guo, BF (reprint author), Hangzhou Dianzi Univ, Sch Automat, Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China. EM gbf@hdu.edu.cn; msn@ecs.soton.ac.uk; rdamarla@arl.army.mil FU Zhejiang Provincial "Qianjiang Rencai" Project of China [2010R10011]; National Natural Science Foundation of China [61004119]; National Basic Research Program of China (973 Program) [2009CB320600, 2009CB320602]; US Army Research Laboratory; UK Ministry of Defence; [W911NF-06-3-0001] FX The Correspondence author is currently sponsored by Zhejiang Provincial "Qianjiang Rencai" Project of China (Grant No. 2010R10011), and partially sponsored by National Natural Science Foundation of China (Grant No. 61004119) and National Basic Research Program of China (973 Program, Grant No. 2009CB320600 or No. 2009CB320602). The research was sponsored by the US Army Research Laboratory and the UK Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the author(s) and should not be interpreted as representing the official policies, either expressed or implied, of the US Army Research Laboratory, the US Government, the UK Ministry of Defence or the UK Government. The US and UK Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 32 TC 6 Z9 6 U1 3 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1433-7541 EI 1433-755X J9 PATTERN ANAL APPL JI Pattern Anal. Appl. PD FEB PY 2012 VL 15 IS 1 BP 29 EP 43 DI 10.1007/s10044-011-0202-5 PG 15 WC Computer Science, Artificial Intelligence SC Computer Science GA 881RN UT WOS:000299505000003 ER PT J AU Sang, QXA Man, YG Sung, YM Khamis, ZI Zhang, LH Lee, MH Byers, SW Sahab, ZJ AF Sang, Qing-Xiang Amy Man, Yan-Gao Sung, You Me Khamis, Zahraa I. Zhang, Lihua Lee, Mi-Hye Byers, Stephen W. Sahab, Ziad J. TI Non-receptor tyrosine kinase 2 reaches its lowest expression levels in human breast cancer during regional nodal metastasis SO CLINICAL & EXPERIMENTAL METASTASIS LA English DT Article DE DCIS; Estrogen receptor alpha; Proteomics; Tissue microdissection; TYK2 ID MYOEPITHELIAL CELL-LAYERS; MAMMARY EPITHELIAL-CELLS; PROTEIN EXPRESSION; TUMOR PROGRESSION; TYK2 EXPRESSION; INVASION; ELECTROPHORESIS; DIFFERENTIATION; INVASIVENESS; DISRUPTIONS AB Almost half of breast Ductal Carcinoma in situ are likely to remain non threatening in situ lesions with no invasion to the surrounding stroma and no metastases. The majority of focal disruptions in myoepithelial (ME) cell layers indicative of invasion onset were found to be overlying epithelial cell clusters with no or substantially reduced estrogen receptor alpha (ER alpha) expression. Here we report the down-regulation of tyrosine kinase-2 (TYK2) and up-regulation of strumpellin expression, among other proteins in ER alpha(-) cells located at disrupted ME layers compared to adjacent ER alpha(+) cells overlying an intact myoepithelial layer. ER alpha(+) and ER alpha(-) cells were microdissected from the same in vivo human breast cancer tissues, proteins were extracted and separated utilizing Differential in-Gel Electrophoresis followed by trypsin digestion, MALDI-TOF analysis, and protein identification. Proteins expressed by ER alpha(-) cell clusters were found to express higher levels of strumpellin that binds to valosin-containing protein (VCP) to slow-down wound closure and promote growth; and lower levels of TYK2, a jak protein necessary for lineage specific differentiation. TYK2 levels were further analyzed by immunohistochemistry in a cohort composed of 70 patients with broad clinical characteristics. TYK2 levels were minimal in TxN1M0 breast cancers which is the stage where the initial regional lymph node metastasis is observed. Our data highlight the role of TYK2 downregulation in breast cancer cell de-differentitation and initiation of regional metastasis. In addition, the aggressiveness of the ER alpha(-) cell clusters compared to ER alpha(+) ones present in the same duct of the same patient was confirmed. C1 [Sung, You Me; Khamis, Zahraa I.; Lee, Mi-Hye; Byers, Stephen W.; Sahab, Ziad J.] Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA. [Sang, Qing-Xiang Amy] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA. [Sang, Qing-Xiang Amy] Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA. [Man, Yan-Gao] Henry Jackson Fdn Adv Mil Med, Diagnost & Translat Res Ctr, Gaithersburg, MD 20789 USA. [Man, Yan-Gao] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Man, Yan-Gao] Jilin Univ, Changchun 130023, Jilin, Peoples R China. RP Sahab, ZJ (reprint author), Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, 3970 Reservoir Rd NW,Suite E415, Washington, DC 20007 USA. EM zjs3@georgetown.edu OI Sahab, Ziad/0000-0003-2330-4018 FU Charles and Mary Latham Fund; Susan G. Komen Breast Cancer Foundation [BCTR0504465, BCTR0706983]; Florida Breast Cancer Coalition Research Foundation; Elsa U. Pardee Foundation; Florida State University; Ministry of Chinese Science and Technology [2006CB910505]; Lombardi Comprehensive Cancer Center [NIH P30 CA51008]; [R01CA129813]; [P01 CA130821] FX This work was supported in part by a grant from the Charles and Mary Latham Fund to ZJ Sahab, grant BCTR0504465 from the Susan G. Komen Breast Cancer Foundation, grants from the Florida Breast Cancer Coalition Research Foundation, the Elsa U. Pardee Foundation, and the Florida State University to Q.-X. Sang, and a grant BCTR0706983 from the Susan G. Komen Breast Cancer Foundation, grant 2006CB910505 from the Ministry of Chinese Science and Technology to Y.-G. Man, and grants R01CA129813 and P01 CA130821 to SW Byers. The authors wish to acknowledge the support of the following Lombardi Comprehensive Cancer Center Core Facilities (NIH P30 CA51008): Tissue culture, Histopathology, Microscopy, and Proteomics shared resources. NR 31 TC 4 Z9 4 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0262-0898 J9 CLIN EXP METASTAS JI Clin. Exp. Metastasis PD FEB PY 2012 VL 29 IS 2 BP 143 EP 153 DI 10.1007/s10585-011-9437-1 PG 11 WC Oncology SC Oncology GA 876FA UT WOS:000299091700007 PM 22116632 ER PT J AU Wildman, JL Thayer, AL Pavlas, D Salas, E Stewart, JE Howse, WR AF Wildman, Jessica L. Thayer, Amanda L. Pavlas, Davin Salas, Eduardo Stewart, John E. Howse, William R. TI Team Knowledge Research: Emerging Trends and Critical Needs SO HUMAN FACTORS LA English DT Article DE shared mental models; transactive memory; cognition; group; methodology ID TRANSACTIVE MEMORY-SYSTEMS; SHARED MENTAL MODELS; PRODUCT DEVELOPMENT TEAMS; TOP MANAGEMENT TEAMS; AIR-TRAFFIC-CONTROL; SITUATION AWARENESS; COGNITIVE UNDERPINNINGS; ENTREPRENEURIAL TEAMS; VENTURE PERFORMANCE; DECISION-MAKING AB Objective: This article provides a systematic review of the team knowledge literature and guidance for further research. Background: Recent research has called attention to the need for the improved study and understanding of team knowledge. Team knowledge refers to the higher level knowledge structures that emerge from the interactions of individual team members. Method: We conducted a systematic review of the team knowledge literature, focusing on empirical work that involves the measurement of team knowledge constructs. For each study, we extracted author degree area, study design type, study setting, participant type, task type, construct type, elicitation method, aggregation method, measurement timeline, and criterion domain. Results: Our analyses demonstrate that many of the methodological characteristics of team knowledge research can be linked back to the academic training of the primary author and that there are considerable gaps in our knowledge with regard to the relationships between team knowledge constructs, the mediating mechanisms between team knowledge and performance, and relationships with criteria outside of team performance, among others. We also identify categories of team knowledge not yet examined based on an organizing framework derived from a synthesis of the literature. Conclusion: There are clear opportunities for expansion in the study of team knowledge; the science of team knowledge would benefit from a more holistic theoretical approach. Application: Human factors researchers are increasingly involved in the study of teams. This review and the resulting organizing framework provide researchers with a summary of team knowledge research over the past 10 years and directions for improving further research. C1 [Salas, Eduardo] Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, Orlando, FL 32826 USA. [Thayer, Amanda L.] Univ Cent Florida, Ind & Org Psychol Program, Orlando, FL 32826 USA. [Stewart, John E.] USA, Res Inst, Ft Rucker, AL USA. [Howse, William R.] Damos Aviat Serv, Gurnee, IL USA. RP Salas, E (reprint author), Univ Cent Florida, Inst Simulat & Training, Human Syst Integrat Res Dept, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM esalas@ist.ucf.edu OI Wildman, Jessica/0000-0002-0004-595X FU Office of Naval Research (ONR); Office of Naval Research Multidisciplinary University Research Initiative (ONR MURI) [N000140610446]; U.S. Army Research Institute, Fort Rucker, Alabama; U.S. Army Research Institute for the Behavioral and Social Sciences [DASW01-03-C-0010] FX This research was partially supported by the Office of Naval Research (ONR) Collaboration and Knowledge Interoperability Program and Office of Naval Research Multidisciplinary University Research Initiative (ONR MURI) Grant No. N000140610446. The research and development reported here was also partially funded by the U.S. Army Research Institute, Fort Rucker, Alabama, and partially supported by the U.S. Army Research Institute for the Behavioral and Social Sciences through contract DASW01-03-C-0010. The views, opinions, and findings contained in this article are the authors' and should not be construed as official or as reflecting the views of the University of Central Florida or the Department of Defense. The authors would like to thank Douglas Gillan (action editor) and two anonymous reviewers for extensive and constructive feedback on previous versions of this article. NR 95 TC 20 Z9 20 U1 7 U2 61 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD FEB PY 2012 VL 54 IS 1 BP 84 EP 111 DI 10.1177/0018720811425365 PG 28 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 878YB UT WOS:000299292200008 PM 22409105 ER PT J AU Sheng, HG Wang, F Tipton, CW AF Sheng, Honggang Wang, Fei (Fred) Tipton, C. Wesley TI A Fault Detection and Protection Scheme for Three-Level DC-DC Converters Based on Monitoring Flying Capacitor Voltage SO IEEE TRANSACTIONS ON POWER ELECTRONICS LA English DT Article DE Flying capacitor; protection; three-level dc-dc converter; voltage unbalance ID ZERO-VOLTAGE; RESONANT CONVERTER; DC/DC CONVERTER; DESIGN AB Fault detection and protection is an important design aspect for any power converter, especially in high-power high-voltage applications, where cost of failure can be high. The three-level dc-dc converter and its varied derivatives are attractive topologies in high-voltage high-power converter applications. The protection method can not only prevent the system failure against unbalanced voltage stresses on the switches, but also provide a remedy for the system as faults occur and save the remaining components. The three-level converter is subject to voltage unbalance in certain abnormal conditions, which can result in switch overvoltage and system failure. The reasons for the unbalanced voltage stresses are fully investigated and categorized. The solutions to each abnormal condition are introduced. In addition to the voltage unbalance, the three-level converters can be protected against multiple faults by the proposed protection method through monitoring the flying capacitor voltage. Phenomena associated with each fault are thoroughly analyzed and summarized. The protection circuit is simple and can be easily implemented, while it can effectively protect the three-level converters and its derivatives, which has been verified by the experiment with a three-level parallel resonant converter. C1 [Sheng, Honggang] Google Inc, Mountain View, CA 94043 USA. [Wang, Fei (Fred)] Univ Tennessee, Dept Elect Engn & Comp Sci, Knoxville, TN 37996 USA. [Tipton, C. Wesley] USA, Res Lab, Adelphi, MD 20783 USA. RP Sheng, HG (reprint author), Google Inc, Mountain View, CA 94043 USA. EM hgsheng@vt.edu; fred.wang@utk.edu FU U.S. Army Research Laboratory [DAAD19-03-2-0008]; National Science Foundation [EEC-9731677]; CPES Industry FX Manuscript received September 6, 2010; revised November 27, 2010, February 23, 2011, April 15, 2011, and June 6, 2011; accepted June 24, 2011. Date of current version January 9, 2012. This work was supported by the U.S. Army Research Laboratory under Grant DAAD19-03-2-0008. This work also made use of Engineering Research Center Shared Facilities supported by the National Science Foundation under NSF Award EEC-9731677 and the CPES Industry Partnership Program. Recommended for publication by Associate Editor J. R. Rodriguez. NR 29 TC 34 Z9 36 U1 2 U2 19 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-8993 J9 IEEE T POWER ELECTR JI IEEE Trans. Power Electron. PD FEB PY 2012 VL 27 IS 2 BP 685 EP 697 DI 10.1109/TPEL.2011.2161333 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 875ZR UT WOS:000299076400001 ER PT J AU Gupta, RK Darling, KS Raman, RKS Ravi, KR Koch, CC Murty, BS Scattergood, RO AF Gupta, Rajeev K. Darling, Kris S. Raman, R. K. Singh Ravi, K. R. Koch, Carl C. Murty, B. S. Scattergood, R. O. TI Synthesis, characterization and mechanical behaviour of an in situ consolidated nanocrystalline FeCrNi alloy SO JOURNAL OF MATERIALS SCIENCE LA English DT Letter ID DECREASING GRAIN-SIZE; COMPACTION; SOLUBILITY; ATTRITION; DUCTILITY; INCREASE; TENSILE; COPPER; ZNO C1 [Gupta, Rajeev K.] Monash Univ, Dept Mat Engn, Clayton, Vic 3800, Australia. [Gupta, Rajeev K.; Raman, R. K. Singh] Monash Univ, Dept Mech & Aerosp Engn, Clayton, Vic 3800, Australia. [Darling, Kris S.] USA, Res Lab, Milwaukee, WI USA. [Raman, R. K. Singh] Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia. [Ravi, K. R.; Murty, B. S.] Indian Inst Technol, Dept Mat & Met Engn, Madras 600036, Tamil Nadu, India. [Koch, Carl C.; Scattergood, R. O.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Gupta, RK (reprint author), Monash Univ, Dept Mat Engn, Clayton, Vic 3800, Australia. EM rajeev.gupta@monash.edu RI Murty, BS/P-3354-2015; OI Gupta, Rajeev/0000-0003-2684-1994; Renga, Ravi/0000-0001-6434-4169 NR 23 TC 8 Z9 8 U1 1 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD FEB PY 2012 VL 47 IS 3 BP 1562 EP 1566 DI 10.1007/s10853-011-5986-6 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 876JR UT WOS:000299104300055 ER PT J AU Tintle, SM Donohue, MA Shawen, S Forsberg, JA Potter, BK AF Tintle, Scott M. Donohue, Michael A. Shawen, Scott Forsberg, Jonathan A. Potter, Benjamin K. TI Proximal Sural Traction Neurectomy During Transtibial Amputations SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE neuroma; transtibial amputation; traction neurectomy; sural nerve ID BELOW-KNEE AMPUTATION; LOWER-EXTREMITY; LIMB AMPUTATION; PHANTOM LIMB; PAIN; OUTCOMES; NERVE; FLAP; RECONSTRUCTION; HEMISOLEUS AB Symptomatic neuroma formation after trauma-related transtibial amputations remains a clinical problem. The sural nerve is frequently overlooked in its vulnerable subcutaneous location in the posterior myofasciocutaneous flap and commonly leads to chronic pain and decreased prosthesis use. The standard sural traction neurectomy may actually predispose the sural neuroma to form in a region that becomes symptomatic with prosthesis wear. The proposed modified proximal sural traction neurectomy using a standard or extended posterior flap begins with identification of the sural nerve in the subcutaneous tissue of the distal flap in identical fashion to a standard sural neurectomy. In the proximal posterior flap, a limited anterior approach is then performed and gentle traction on the distal end of the sural nerve aids in the identification of the most proximally accessible portion of the medial sural cutaneous nerve. After locating the medial sural cutaneous nerve proximally, a neurectomy at this location is performed, allowing the retraction of the nerve into a healthy tissue bed substantially more proximal than with a standard sural neurectomy. This technique ensures that the resulting neuroma does not form directly at the distal end of the residual limb where it is, in our experience, more likely to become symptomatic. C1 [Potter, Benjamin K.] Walter Reed Army Med Ctr, Amputee Patient Care Program, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. [Donohue, Michael A.; Shawen, Scott; Forsberg, Jonathan A.; Potter, Benjamin K.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Potter, BK (reprint author), Walter Reed Army Med Ctr, Amputee Patient Care Program, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. EM kyle.potter@us.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 38 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD FEB PY 2012 VL 26 IS 2 BP 123 EP 126 DI 10.1097/BOT.0b013e318214fd7b PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 877RQ UT WOS:000299200000016 PM 21804416 ER PT J AU Orestes, MI Lander, L Verghese, S Shah, RK AF Orestes, Michael I. Lander, Lina Verghese, Susan Shah, Rahul K. TI Incidence of laryngospasm and bronchospasm in pediatric adenotonsillectomy SO LARYNGOSCOPE LA English DT Article DE Tonsillectomy; adenoidectomy; outcomes; laryngospasm; bronchospasm; Level of Evidence: 2b ID CHILDREN; TONSILLECTOMY; COMPLICATIONS; ANESTHESIA; AIRWAY AB Objectives/Hypothesis: To evaluate and describe airway complications in pediatric adenotonsillectomy. C1 [Shah, Rahul K.] Childrens Natl Med Ctr, Div Otolaryngol, Washington, DC 20010 USA. [Orestes, Michael I.] Walter Reed Army Med Ctr, Natl Capitol Consortium, Otolaryngol Residency Training Program, Washington, DC 20307 USA. [Lander, Lina] Univ Nebraska Med Ctr, Dept Epidemiol, Omaha, NE USA. [Verghese, Susan] Childrens Natl Med Ctr, Div Anesthesiol, Washington, DC 20010 USA. RP Shah, RK (reprint author), Childrens Natl Med Ctr, Div Otolaryngol, 111 Michigan Ave NW, Washington, DC 20010 USA. EM rshah@childrensnational.org OI Orestes, Michael/0000-0001-8477-975X NR 14 TC 11 Z9 12 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD FEB PY 2012 VL 122 IS 2 BP 425 EP 428 DI 10.1002/lary.22423 PG 4 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 880AA UT WOS:000299374900032 PM 22252947 ER PT J AU Vargas-Gonzalez, LR Walsh, SM Pappas, DD AF Vargas-Gonzalez, Lionel R. Walsh, Shawn M. Pappas, Daphne D. TI Control of the interfacial properties of ultrahigh-molecular-weight polyethylene/magnesium hybrid composites through use of atmospheric plasma treatment SO POLYMER COMPOSITES LA English DT Article ID DISCHARGE; POLYMERS; FIBERS AB This work aims to explore the use of lightweight magnesium alloys as an advanced composite material in conjunction with lightweight thermoplastic materials, such as ultrahigh-molecular-weight polyethylene (UHMWPE). High throughput, environmentally friendly, atmospheric plasma treatment methods were used to control the interfacial properties and improve the adhesion behavior of metallic/UHMWPE composites. Helium-oxygen dielectric barrier discharges were used, and the plasma-activated UHMWPE surfaces were characterized through analytical and mechanical characterization methods. Oxygen content on the treated polymer surfaces increased 18.136.0%. A reduction in silicon content combined with characterization through microscopy reveal a preference for the attack of the matrix over the polyethylene fibers. Wetting angles for the treated samples decreased as much as 53.7%. Treated UHMWPE/Mg hybrid samples exhibited lap shear strengths up to 113.7% greater than the control. Both the plasma-induced surface functionalization with oxygen-containing polar groups (carboxyl, carbonyl, and hydroxyl groups) and the preferential mild etching of the polymer matrix over the fibers lead to the improvement in adhesion. POLYM. COMPOS., 2012. (c) 2011 Society of Plastics Engineers C1 [Vargas-Gonzalez, Lionel R.; Walsh, Shawn M.; Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Vargas-Gonzalez, LR (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM lionel.r.vargas.civ@mail.mil OI Vargas-Gonzalez, Lionel/0000-0001-6500-1686; Pappas, Daphne/0000-0002-5746-8873 NR 16 TC 1 Z9 1 U1 1 U2 16 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0272-8397 J9 POLYM COMPOSITE JI Polym. Compos. PD FEB PY 2012 VL 33 IS 2 BP 207 EP 214 DI 10.1002/pc.22139 PG 8 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA 876IG UT WOS:000299100400006 ER PT J AU Propper, RE Brunye, TT Christman, SD Januszewskia, A AF Propper, Ruth E. Brunye, Tad T. Christman, Stephen D. Januszewskia, Ashley TI Look over there! Unilateral gaze increases geographical memory of the 50 United States SO BRAIN AND COGNITION LA English DT Article DE Memory; Hemisphere; Lateralization; Semantic ID VISUAL-FIELD STIMULATION; ASYMMETRY; ALPHA AB Based on their specialized processing abilities, the left and right hemispheres of the brain may not contribute equally to recall of general world knowledge. US college students recalled the verbal names and spatial locations of the 50 US states while sustaining leftward or rightward unilateral gaze, a procedure that selectively activates the contralateral hemisphere. Compared to a no-unilateral gaze control, right gaze/left hemisphere activation resulted in better recall, demonstrating left hemisphere superiority in recall of general world knowledge and offering equivocal support for the hemispheric encoding asymmetry model of memory. Unilateral gaze- regardless of direction- improved recall of spatial, but not verbal, information. Future research could investigate the conditions under which unilateral gaze increases recall. Sustained unilateral gaze can be used as a simple, inexpensive, means for testing theories of hemispheric specialization of cognitive functions. Results support an overall deficit in US geographical knowledge in undergraduate college students. (C) 2011 Elsevier Inc. All rights reserved. C1 [Propper, Ruth E.] Montclair State Univ, Dept Psychol, Montclair, NJ 07043 USA. [Brunye, Tad T.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.] USA, Res Dev & Engn Command, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Christman, Stephen D.] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA. [Januszewskia, Ashley] Merrimack Coll, Dept Psychol, N Andover, MA 01845 USA. RP Propper, RE (reprint author), Montclair State Univ, Dept Psychol, 225 Dickson Hall,1 Normal Ave, Montclair, NJ 07043 USA. EM ruth.propper@merrimack.edu FU US Army [W911QY-09-P-0567, W911QY-10-P0420] FX Supported by US Army Contracts #W911QY-09-P-0567 and W911QY-10-P0420. Opinions expressed herein are those of the authors and not necessarily of the US Army. The authors thank Charles StagnoScotto for data coding and entry. NR 16 TC 3 Z9 3 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0278-2626 J9 BRAIN COGNITION JI Brain Cogn. PD FEB PY 2012 VL 78 IS 1 BP 59 EP 62 DI 10.1016/j.bandc.2011.10.002 PG 4 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 874RR UT WOS:000298976300007 PM 22061174 ER PT J AU Jayakumar, C Nargunde, J Sinha, A Bryzik, W Henein, NA Sattler, E AF Jayakumar, Chandrasekharan Nargunde, Jagdish Sinha, Anubhav Bryzik, Walter Henein, Naeim A. Sattler, Eric TI Effect of Biodiesel, Jet Propellant (JP-8) and Ultra Low Sulfur Diesel Fuel on Auto-Ignition, Combustion, Performance and Emissions in a Single Cylinder Diesel Engine SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article AB Concern about the depletion of petroleum reserves, rising prices of conventional fuels, security of supply and global warming have driven research toward the development of renewable fuels for use in diesel engines. These fuels have different physical and chemical properties that affect the diesel combustion process. This paper compares between the autoignition, combustion, performance and emissions of soy-bean derived biodiesel, Jet propellant (JP-8) and ultra low sulfur diesel (ULSD) in a high speed single-cylinder research diesel engine equipped with a common rail injection system. Tests were conducted at steady state conditions at different injection pressures ranging from 600 bar to 1200 bar. The 'rate of heat release' traces are analyzed to determine the effect of fuel properties on the ignition delay, premixed combustion fraction and mixing and diffusion controlled combustion fractions. Biodiesel produced the largest diffusion controlled combustion fraction at all injection pressures compared to ULSD and JP-8. At 600 bar injection pressure, the diffusion controlled combustion fraction for biodiesel was 53% whereas both JP-8 and ULSD produced 39%. In addition, the effect of fuel properties on engine performance, fuel economy, and engine-out emissions is determined. On an average JP-8 produced 3% higher thermal efficiency than ULSD. Special attention is given to the oxides of nitrogen (NO(x)) emissions and particulate matter characteristics. On an average biodiesel produced 37% less NO(x) emissions compared to ULSD and JP-8. [DOI: 10.1115/1.4003971] C1 [Jayakumar, Chandrasekharan; Nargunde, Jagdish; Sinha, Anubhav; Bryzik, Walter; Henein, Naeim A.] Wayne State Univ, Detroit, MI 48201 USA. [Sattler, Eric] USA, Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Jayakumar, C (reprint author), Wayne State Univ, 5050 Anthony Wayne Dr,Suite 2100, Detroit, MI 48201 USA. FU U.S. Army TARDEC-NAC; U.S. Dept. of Energy, Next Energy; Automotive Research Center (ARC); U.S. Army TARDEC FX This research was sponsored by U.S. Army TARDEC-NAC, U.S. Dept. of Energy, Next Energy, Automotive Research Center (ARC) sponsored by U.S. Army TARDEC and directed by University of Michigan. The authors acknowledge the help provided NBEL team at Wayne State University, Lidia Nedeltcheva, Eugene and his team. Special thanks are due to Laura Hoogterp from U.S. Army TARDEC for supplying the fuels. NR 39 TC 3 Z9 3 U1 0 U2 13 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD FEB PY 2012 VL 134 IS 2 AR 022801 DI 10.1115/1.4003971 PG 11 WC Engineering, Mechanical SC Engineering GA 868RB UT WOS:000298540500016 ER PT J AU Grew, KN Chiu, WKS AF Grew, Kyle N. Chiu, Wilson K. S. TI A review of modeling and simulation techniques across the length scales for the solid oxide fuel cell SO JOURNAL OF POWER SOURCES LA English DT Review DE Atomistic; Fuel cell; HeteroFoaM; Mesoscale; Multiscale modeling; Quantum ID LATTICE BOLTZMANN-METHOD; YTTRIA-STABILIZED ZIRCONIA; MONTE-CARLO-SIMULATION; THERMAL-STRESS ANALYSIS; PHASE-FIELD METHOD; SPACE-CHARGE; SOFC ELECTRODES; ION-TRANSPORT; POLARIZATION RESISTANCE; 1ST-PRINCIPLES ANALYSIS AB Recent advances in computational techniques have allowed the application of computational tools to study heterogeneous functional materials (HeteroFoaMs) in the solid oxide fuel cell (SOFC) from the quantum (sub-atomic) to atomistic to the continuum scales. However, knowledge gained from a particular computational technique can only provide insight at that specific scale. There has been a recent interest to develop a more cohesive effort so that results obtained from models across a particular spatial dimension can be used to extract additional insight across a larger range of length scales. This review article surveys recent progress in the modeling and simulation of SOFCs, and relates them to the relevant physical phenomena and length/time scales. We then proceed to review the various numerical techniques used, and their applicability across the length and time scales. (C) 2011 Elsevier BV. All rights reserved. C1 [Chiu, Wilson K. S.] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Grew, Kyle N.] USA, Res Lab, Sensors & Electron Devices Directorate, RDRL SED C, Adelphi, MD 20783 USA. RP Chiu, WKS (reprint author), Univ Connecticut, Dept Mech Engn, 191 Auditorium Rd, Storrs, CT 06269 USA. EM wchiu@engr.uconn.edu RI Grew, Kyle/K-3982-2013 OI Grew, Kyle/0000-0002-1645-3835 FU Energy Frontier Research Center on Science Based Nano-Structure Design and Synthesis of Heterogeneous Functional Materials for Energy Systems; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001061]; U.S. Army Research Laboratory FX WKSC gratefully acknowledges financial support from the Energy Frontier Research Center on Science Based Nano-Structure Design and Synthesis of Heterogeneous Functional Materials for Energy Systems (HeteroFoaM Center) funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences (Award DE-SC0001061). KNG gratefully acknowledges that this effort was supported, in part, by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory with financial support from the U.S. Department of the Army and the U.S. Army Materiel Command. The authors are grateful to Prof. Emily A. Carter at Princeton University, Prof. Kenneth L. Reifsnider at the University of South Carolina, Prof. Anil V. Virkar at the University of Utah, and Dr. Deryn Chu of the U.S. Army Research Laboratory for invaluable discussion and support. NR 169 TC 41 Z9 42 U1 10 U2 125 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 EI 1873-2755 J9 J POWER SOURCES JI J. Power Sources PD FEB 1 PY 2012 VL 199 BP 1 EP 13 DI 10.1016/j.jpowsour.2011.10.010 PG 13 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 864VX UT WOS:000298269700001 ER PT J AU Florea, RS Solanki, KN Bammann, DJ Baird, JC Jordon, JB Castanier, MP AF Florea, R. S. Solanki, K. N. Bammann, D. J. Baird, J. C. Jordon, J. B. Castanier, M. P. TI Resistance spot welding of 6061-T6 aluminum: Failure loads and deformation SO MATERIALS & DESIGN LA English DT Article ID SHEETS; SIMULATION AB This study offers a novel research approach to compare weld quality for different welding conditions in order to achieve optimal end-product results. Using electron back scatter diffraction (EBSD) scanning, tensile testing, and laser beam profilometry (LBP) measurements along with optical microscopy (OM) images, failure loads and deformation of 6061-T6 aluminum alloy, resistance spot welded (RSW) joints were experimentally investigated. Three welding conditions, nugget and microstructure characteristics were quantified according to predefined process parameters. Quasi-static tensile tests were used to characterize the failure loads in specimens based upon these same process parameters. Profilometer results showed that the larger the applied welding current, the deeper the weld imprints. In addition, good correlation was obtained between the EBSD scans and the welding conditions. A strong dependency was found between the grain size and orientation and the welding parameters. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Florea, R. S.; Solanki, K. N.; Baird, J. C.] Ctr Adv Vehicular Syst, Starkville, MS 39759 USA. [Bammann, D. J.] Mississippi State Univ, Mississippi State, MS USA. [Jordon, J. B.] Univ Alabama, Tuscaloosa, AL 35487 USA. [Castanier, M. P.] USA, TARDEC, RDTA RS, Warren, MI 48397 USA. RP Florea, RS (reprint author), Ctr Adv Vehicular Syst, 200 Res Blvd, Starkville, MS 39759 USA. EM rf2@msstate.edu RI Solanki, Kiran/E-8337-2010; OI Castanier, Matthew/0000-0002-3646-382X; Solanki, Kiran/0000-0002-4385-620X FU Center of Advanced Vehicular Systems at Mississippi State University; US Army-TAR-DEC; US Army TACOM Life Cycle Command [W56HZV-08-C-0236]; Mechanical Engineering Department at Mississippi State University FX The authors would like to thank the Center of Advanced Vehicular Systems at Mississippi State University and the US Army-TAR-DEC for supporting this work. This material is based upon work supported by the US Army TACOM Life Cycle Command under Contract No. W56HZV-08-C-0236 and was performed for the Simulation Based Reliability and Safety (SimBRS) research program. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the US Army TACOM Life Cycle Command. J.C. Baird offers thanks to the Mechanical Engineering Department at Mississippi State University for funding this research. NR 23 TC 13 Z9 13 U1 3 U2 34 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0261-3069 J9 MATER DESIGN JI Mater. Des. PD FEB PY 2012 VL 34 BP 624 EP 630 DI 10.1016/j.matdes.2011.05.017 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA 862UT UT WOS:000298120300083 ER PT J AU Tannenbaum, LV Borry, BE AF Tannenbaum, Lawrence V. Borry, Barrett E. TI Pilot study for a sperm quality-based reproductive assessment scheme for deer SO ECOLOGICAL INDICATORS LA English DT Article DE Sperm; Sperm count; White-tailed deer; Ecological risk assessment; Reproduction ID MICE; RISK AB Ecological risk assessments (ERAs) for mammals at chemically contaminated terrestrial sites conventionally apply a food-chain model to draw inferences about a population's reproductive condition. Very recently though, the ERA field was advanced beyond the desktop level with the introduction of Rodent Sperm Analysis (RSA), a direct health status assessment method for the actual chemically exposed site receptor. Here, the sperm parameters of rodents (count, motility, morphology) of contaminated sites and their habitat-matched noncontaminated reference locations are comparatively reviewed for a technically supported indication of reproductive capability. ERA's toxicological endpoint of greatest concern. With the extent to which sperm parameters need to be impaired in order to compromise reproduction being known, more definitive determinations are possible than with the food-chain model approach. We sought to adapt the RSA method to the white-tailed deer (Odocoileus virginianus), recognizing that this commonly evaluated mammalian species of ERAs is one of a very few species that avails itself to regularly being removed (through hunting) from the field. We conclude that the adaptation is viable, although sperm motility and a few other measures routinely compiled in RSA applications cannot be collected. In the pilot application, the deer population we assessed, with exposures to Superfund and other sites of known contamination, was not found to have compromised reproduction. This finding is consistent with RSA's supporting theory as well as population census information. The outcomes of so-called deer sperm analysis applications for herds exposed to one or more environmental stressors, have the potential to serve as reliable indicators of reproductive status. Such outcomes also provide further weight-of-evidence that suspected contamination is not associated with adverse ecological effects. Published by Elsevier Ltd. C1 [Tannenbaum, Lawrence V.] USA, Inst Publ Hlth, Environm Hlth Risk Assessment Program, MCHB IP REH, Apg Ea, MD 21010 USA. [Borry, Barrett E.] USA, Inst Publ Hlth, Groundwater & Solid Waste Program, MCHB TS EGW, Apg Ea, MD 21010 USA. RP Tannenbaum, LV (reprint author), USA, Inst Publ Hlth, Environm Hlth Risk Assessment Program, MCHB IP REH, Bldg 1675, Apg Ea, MD 21010 USA. EM larry.tannenbaum@us.army.mil; barrett.borry@us.army.mil FU U.S. Army Environmental Command FX The authors wish to first thank the U.S. Army Environmental Command (Mr. Jim Daniel) for funding this study. We also thank Mr. Tom Ward of the Aberdeen Archery Club, the employees and volunteer hunters of APG-AA's deer check-in station, and the U.S. Fish and Wildlife Service personnel that managed the ENWR's hunting program. The helpful comments on the manuscript of Mr. Dennis Druck and Ms. Sherri Hutchens are appreciated as are the editing skills of Ms. Joyce Woods. NR 21 TC 0 Z9 0 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1470-160X J9 ECOL INDIC JI Ecol. Indic. PD FEB PY 2012 VL 13 IS 1 BP 152 EP 157 DI 10.1016/j.ecolind.2011.05.021 PG 6 WC Biodiversity Conservation; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 835NG UT WOS:000296042500016 ER PT J AU Mirsaidov, UM Zheng, HM Casana, Y Matsudaira, PT AF Mirsaidov, Utkur M. Zheng, Haimei Casana, Yosune Matsudaira, Paul T. TI Imaging Protein in Water with Nanometer Resolution SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract CT 56th Annual Meeting of the Biophysical-Society CY FEB 25-29, 2012 CL San Diego, CA SP Biophys Soc C1 [Mirsaidov, Utkur M.; Casana, Yosune; Matsudaira, Paul T.] Natl Univ Singapore, Singapore 117548, Singapore. [Zheng, Haimei] USA, Lawrence Berkeley Natl Lab, Berkeley, CA USA. NR 0 TC 1 Z9 1 U1 0 U2 4 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD JAN 31 PY 2012 VL 102 IS 3 SU 1 BP 386A EP 387A PG 2 WC Biophysics SC Biophysics GA 179ZF UT WOS:000321561202545 ER PT J AU Cox, ME Kecskes, LJ Mathaudhu, SN Dunand, DC AF Cox, Marie E. Kecskes, Laszlo J. Mathaudhu, Suveen N. Dunand, David C. TI Amorphous Hf-based foams with aligned, elongated pores SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Bulk amorphous alloy; Cellular materials; Porous materials; Equal channel angular processing; Hafnium-based glassy alloy ID BULK METALLIC-GLASS; CHANNEL ANGULAR EXTRUSION; MATRIX COMPOSITES; MECHANICAL-BEHAVIOR; POWDER; ALLOYS; CONSOLIDATION; DEFORMATION; CRYSTALLIZATION; PLASTICITY AB Warm equal channel angular extrusion is used to consolidate a blend of amorphous Hf44.5Cu27Ni13.5Ti5Al10 and crystalline W powders. Dissolution of the W phase results in similar to 60% aligned, elongated pores within an amorphous Hf-based matrix exhibiting ductility in compression, but at lower strengths than similar amorphous Zr-based foams due to incomplete bonding between Hf-based powders. (C) 2011 Elsevier B.V. All rights reserved. C1 [Cox, Marie E.; Dunand, David C.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. [Kecskes, Laszlo J.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Mathaudhu, Suveen N.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Dunand, DC (reprint author), Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. EM dunand@northwestern.edu RI Dunand, David/B-7515-2009; Mathaudhu, Suveen/B-4192-2009; Kecskes, Laszlo/F-6880-2014; OI Kecskes, Laszlo/0000-0002-1342-3729; Dunand, David/0000-0001-5476-7379 FU National Science Foundation FX MEC was supported by a National Science Foundation Graduate Research Fellowship. The authors thank Mr. Larry Jones at Ames Laboratory (Department of Energy) for BMG powder preparation; they acknowledge useful discussions with, and use of the ECAE equipment of, Prof. K. Ted Hartwig (Texas A&M University, TAMU) as well as the experimental assistance of Mr. Robert Barber (TAMU) in operating the equipment. NR 36 TC 4 Z9 4 U1 0 U2 15 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JAN 30 PY 2012 VL 533 BP 124 EP 127 DI 10.1016/j.msea.2011.11.032 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 891GS UT WOS:000300205800017 ER PT J AU Balu, R Zhong, XL Pandey, R Karna, SP AF Balu, Radhakrishnan Zhong, Xiaoliang Pandey, Ravindra Karna, Shashi P. TI Effect of electric field on the band structure of graphene/boron nitride and boron nitride/boron nitride bilayers SO APPLIED PHYSICS LETTERS LA English DT Article ID TUNABLE BANDGAP; MOLECULES AB Effect of electric field on the band structures of graphene/boron nitride (BN) and BN/BN bilayers is investigated within the framework of density functional theory. The calculated bandgap of the graphene/BN bilayer increases, although by small amount, with applied electric field. In the case of BN/BN bilayer, the bandgap decreases with the applied field in agreement with earlier studies. The modulation of bandgap in graphene/BN bilayers is dominated by the features of graphene and appears to be related to the modification in molecular orbitals as revealed by the calculated projected density of states. (C) 2012 American Institute of Physics. [doi:10.1063/1.3679174] C1 [Balu, Radhakrishnan; Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. [Zhong, Xiaoliang; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. RP Balu, R (reprint author), USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. EM rad.balu@us.army.mil; shashi.karna@us.army.mil RI Zhong, Xiaoliang/B-2220-2012 FU U.S. Army Research Laboratory [W911NF-09-2-0026-133417] FX Calculations were performed using the DOD Supercomputing Resource Centers (DSRCs) located at the U.S. Army Engineer Research and Development Center. The work at Michigan Technological University was performed under support by the U.S. Army Research Laboratory through Contract No. W911NF-09-2-0026-133417. NR 18 TC 43 Z9 43 U1 2 U2 46 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 30 PY 2012 VL 100 IS 5 AR 052104 DI 10.1063/1.3679174 PG 3 WC Physics, Applied SC Physics GA 889HW UT WOS:000300065300028 ER PT J AU Sliozberg, YR Andzelm, JW AF Sliozberg, Yelena R. Andzelm, Jan W. TI Fast protocol for equilibration of entangled and branched polymer chains SO CHEMICAL PHYSICS LETTERS LA English DT Article ID DISSIPATIVE PARTICLE DYNAMICS; MOLECULAR-DYNAMICS; SIMULATIONS; MELTS; MODEL; SYSTEMS AB Direct brute-force equilibration of well-entangled polymers is beyond the reach of the modern computational power because of slow reptation dynamics exhibited by high molecular weight chains. We have introduced a fast protocol to prepare well-equilibrated entangled polymer melts of various architectures. A soft, DPD-like potential is used to quickly equilibrate the melt at intermediate length-scale following with a replacement of the DPD potential with Lennard-Jones potential. The equilibrated structure is then subjected to a short MD simulation run that relaxes the melt configuration at the short length-scale. The topological characteristics of the final melt structure are excellent, and the method found to be computationally competitive to other state-of-the-art equilibration techniques. (C) 2011 Elsevier B. V. All rights reserved. C1 [Sliozberg, Yelena R.; Andzelm, Jan W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sliozberg, YR (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM yelena.r.sliozberg@us.army.mil FU US Army Research Laboratory Enterprise for Multi-scale Research of Materials; US Army Research Laboratory (ARL) FX This work was funded by the US Army Research Laboratory Enterprise for Multi-scale Research of Materials. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the US Army Research Laboratory (ARL), administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the US Department of Energy and ARL. We are grateful to Joseph L. Lenhart, Jay Schieber and Robert S. Hoy for productive discussion. The authors thank Martin Krger for providing Z1 code. NR 20 TC 14 Z9 14 U1 1 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JAN 27 PY 2012 VL 523 BP 139 EP 143 DI 10.1016/j.cplett.2011.12.040 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 879EM UT WOS:000299312500028 ER PT J AU Moon, JJ Suh, H Li, AV Ockenhouse, CF Yadava, A Irvine, DJ AF Moon, James J. Suh, Heikyung Li, Adrienne V. Ockenhouse, Christian F. Yadava, Anjali Irvine, Darrell J. TI Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand T-fh cells and promote germinal center induction SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID PLASMODIUM-VIVAX; CIRCUMSPOROZOITE PROTEIN; ANTIBODY-RESPONSES; SUBCAPSULAR SINUS; EPITOPE DENSITY; B-CELLS; IMMUNOGENICITY; SPOROZOITES; FALCIPARUM; IMMUNITY AB For subunit vaccines, adjuvants play a key role in shaping immunological memory. Nanoparticle (NP) delivery systems for antigens and/or molecular danger signals are promising adjuvants capable of promoting both cellular and humoral immune responses, but in most cases the mechanisms of action of these materials are poorly understood. Here, we studied the immune response elicited by NPs composed of multilamellar "stapled" lipid vesicles carrying a recombinant Plasmodium vivax circumsporozoite antigen, VMP001, both entrapped in the aqueous core and anchored to the lipid bilayer surfaces. Immunization with these particles and monophosphoryl lipid A (MPLA), a US Food and Drug Administration-approved immunostimulatory agonist for Toll-like receptor-4, promoted high-titer, high-avidity antibody responses against VMP001, lasting more than 1 y in mice at 10-fold lower doses than conventional adjuvants. Compared to soluble VMP001 mixed with MPLA, VMP001-NPs promoted broader humoral responses, targeting multiple epitopes of the protein and a more balanced Th1/Th2 cytokine profile from antigen-specific T cells. To begin to understand the underlying mechanisms, we examined components of the B-cell response and found that NPs promoted robust germinal center (GC) formation at low doses of antigen where no GC induction occurred with soluble protein immunization, and that GCs nucleated near depots of NPs accumulating in the draining lymph nodes over time. In parallel, NP vaccination enhanced the expansion of antigen-specific follicular helper T cells (T-fh), compared to vaccinations with soluble VMP001 or alum. Thus, NP vaccines may be a promising strategy to enhance the durability, breadth, and potency of humoral immunity by enhancing key elements of the B-cell response. C1 [Moon, James J.; Suh, Heikyung; Irvine, Darrell J.] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. [Moon, James J.; Suh, Heikyung; Li, Adrienne V.; Irvine, Darrell J.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. [Ockenhouse, Christian F.; Yadava, Anjali] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Irvine, Darrell J.] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Irvine, Darrell J.] Massachusetts Gen Hosp, Ragon Inst, MIT, Boston, MA 02129 USA. [Irvine, Darrell J.] Harvard Univ, Boston, MA 02129 USA. [Suh, Heikyung; Irvine, Darrell J.] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA. RP Irvine, DJ (reprint author), MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA. EM djirvine@mit.edu FU Ragon Institute of Massachusetts General Hospital; Massachusetts Institute of Technology; Harvard University; Gates Foundation; Department of Defense [W911NF-07-D-0004]; National Institutes of Health [AI095109, 1U19AI091693] FX This work was supported in part by the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University; the Gates Foundation; the Department of Defense (Contract W911NF-07-D-0004); and National Institutes of Health (AI095109 and 1U19AI091693). D.J.I. is an investigator of the Howard Hughes Medical Institute. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 30 TC 121 Z9 122 U1 4 U2 61 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JAN 24 PY 2012 VL 109 IS 4 BP 1080 EP 1085 DI 10.1073/pnas.1112648109 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 880NA UT WOS:000299412600023 PM 22247289 ER PT J AU Paris, R Bejrachandra, S Thongcharoen, P Nitayaphan, S Pitisuttithum, P Sambor, A Gurunathan, S Francis, D Ratto-Kim, S Karnasuta, C de Souza, MS Polonis, VR Brown, AE Kim, JH Stephens, HA AF Paris, Robert Bejrachandra, Sasitorn Thongcharoen, Prasert Nitayaphan, Sorachai Pitisuttithum, Punnee Sambor, Anna Gurunathan, Sanjay Francis, Donald Ratto-Kim, Silvia Karnasuta, Chitraporn de Souza, Mark S. Polonis, Victoria R. Brown, Arthur E. Kim, Jerome H. Stephens, Henry A. CA AIDS Vaccine Evaluation Grp Taveg TI HLA class II restriction of HIV-1 clade-specific neutralizing antibody responses in ethnic Thai recipients of the RV144 prime-boost vaccine combination of ALVAC-HIV and AIDSVAX (R) B/E SO VACCINE LA English DT Article DE HIV-1; Vaccine; Neutralizing antibody; HLA; MHC; RV144; RV135 ID DEPENDENT DIABETES-MELLITUS; SUBTYPE-E; POLYMORPHISM; TYPE-1; GP120; IMMUNOGENICITY; SUSCEPTIBILITY; ASSOCIATIONS; HAPLOTYPES; DIVERSITY AB Immune responses to vaccines may be influenced or associated with allelic variants of host genes such as those encoding human leucocyte antigens (HLA). We have molecularly determined the HLA class II DR and DQ gene, allele and haploype profiles in HIV-1 negative ethnic Thai recipients of an HIV-1 prime boost vaccine regimen, designed to induce neutralizing antibody (NAb) responses to HIV-1 CRF01_AE. Non-response to vaccine associated with DRB1*11 (3/32 responders vs. 7/13 non-responders, p(c) = 0.027) and DRB1*16:02 (0/32 responders vs. 4/13 non-responders,p(c) = 0.078) alleles. Furthermore, vaccine recipients with HLA-DQ heterodimers encoded by DQA1*05:01 and DQB1*03:01 alleles, were much less likely to produce NAb (p = 0.009). These data suggest that the lack of response to a vaccine designed to induce clade-specific NAb to HIV-1 is associated with the presence of certain HLA class II alleles and heterodimers in some Southeast Asians. (C) 2011 Published by Elsevier Ltd. C1 [Paris, Robert; Nitayaphan, Sorachai; Karnasuta, Chitraporn; de Souza, Mark S.; Brown, Arthur E.] Dept Retrovirol, Bangkok, Thailand. [Paris, Robert; Nitayaphan, Sorachai; Karnasuta, Chitraporn; de Souza, Mark S.; Brown, Arthur E.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Bejrachandra, Sasitorn; Thongcharoen, Prasert] Siriraj Hosp, Dept Microbiol & Transfus Med, Fac Med, Bangkok, Thailand. [Pitisuttithum, Punnee] Mahidol Univ, Vaccine Trial Ctr, Fac Trop Med, Bangkok 10700, Thailand. [Sambor, Anna; Ratto-Kim, Silvia; Polonis, Victoria R.] Henry M Jackson Fdn, Rockville, MD USA. [Gurunathan, Sanjay] Sanofi Pasteur, Swiftwater, PA USA. [Francis, Donald] Global Solut Infect Dis, Brisbane, Qld, Australia. [Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD USA. [Stephens, Henry A.] Royal Free Hosp, UCL Ctr Nephrol, London NW3 2QG, England. [Stephens, Henry A.] Royal Free Hosp, Anthony Nolan Trust, London NW3 2QG, England. RP Paris, R (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM robert.paris@us.army.mil FU US Army Medical Research [DAMD17-98-2-7007]; Henry M. Jackson Foundation FX Support for this study was provided by the US Army Medical Research and Materiel Command through Cooperative Agreement (DAMD17-98-2-7007) with the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 30 TC 19 Z9 19 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 20 PY 2012 VL 30 IS 5 BP 832 EP 836 DI 10.1016/j.vaccine.2011.11.002 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 909IK UT WOS:000301558000004 PM 22085554 ER PT J AU Kamau, E Alemayehu, S Feghali, KC Tolbert, LS Ogutu, B Ockenhouse, CF AF Kamau, Edwin Alemayehu, Saba Feghali, Karla C. Tolbert, LaDonna S. Ogutu, Bernard Ockenhouse, Christian F. TI Development of a TaqMan Allelic Discrimination Assay for detection of Single Nucleotides Polymorphisms associated with anti-malarial drug resistance SO MALARIA JOURNAL LA English DT Article ID REAL-TIME PCR; PLASMODIUM-FALCIPARUM MALARIA; PAPUA-NEW-GUINEA; MOLECULAR MARKERS; SULFADOXINE-PYRIMETHAMINE; CHLOROQUINE RESISTANCE; PARASITE RESISTANCE; FAILURE; PFCRT AB Background: Anti-malarial drug resistance poses a threat to current global efforts towards control and elimination of malaria. Several methods are used in monitoring anti-malarial drug resistance. Molecular markers such as single nucleotide polymorphism (SNP) for example are increasingly being used to identify genetic mutations related to anti-malarial drug resistance. Several methods are currently being used in analysis of SNP associated with antimalarial drug resistance and although each one of these methods has unique strengths and shortcoming, there is still need to improve and/or develop new methods that will close the gap found in the current methods. Methods: TaqMan Allelic Discrimination assays for detection of SNPs associated with anti-malarial drug resistance were designed for analysis on Applied Biosystems PCR platform. These assays were designed by submitting SNP sequences associated with anti-malarial drug resistance to Applied Biosystems website. Eleven SNPs associated with resistance to anti-malarial drugs were selected and tested. The performance of each SNP assay was tested by creating plasmid DNAs carrying codons of interests and analysing them for analysis. To test the sensitivity and specificity of each SNP assay, 12 clinical samples were sequenced at codons of interest and used in the analysis. Plasmid DNAs were used to establish the Limit of Detection (LoD) for each assay. Results: Data from genetic profiles of the Plasmodium falciparum laboratory strains and sequence data from 12 clinical samples was used as the reference method with which the performance of the SNP assays were compared to. The sensitivity and specificity of each SNP assay was establish at 100%. LoD for each assay was established at 2 GE, equivalent to less than 1 parasite/mu L. SNP assays performed well in detecting mixed infection and analysis of clinical samples. Conclusion: TaqMan Allelic Discrimination assay provides a good alternative tool in detection of SNPs associated with anti-malarial drug. C1 [Kamau, Edwin; Alemayehu, Saba; Feghali, Karla C.; Ockenhouse, Christian F.] Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Dept Mol Diagnost & Genom Studies, Silver Spring, MD 20910 USA. [Tolbert, LaDonna S.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. [Ogutu, Bernard] Kenya Govt Med Res Ctr, Walter Reed Project, Kisumu, Kenya. RP Kamau, E (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Dept Mol Diagnost & Genom Studies, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Edwin.kamau@us.army.mil NR 29 TC 8 Z9 8 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JAN 20 PY 2012 VL 11 AR 23 DI 10.1186/1475-2875-11-23 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 893MC UT WOS:000300359000001 PM 22264294 ER PT J AU Chen, ZY Leung, LY Mountney, A Liao, ZL Yang, WH Lu, XCM Dave, J Deng-Bryant, Y Wei, G Schmid, K Shear, DA Tortella, FC AF Chen, Zhiyong Leung, Lai Yee Mountney, Andrea Liao, Zhilin Yang, Weihong Lu, Xi-Chun May Dave, Jitendra Deng-Bryant, Ying Wei, Guo Schmid, Kara Shear, Deborah A. Tortella, Frank C. TI A Novel Animal Model of Closed-Head Concussive-Induced Mild Traumatic Brain Injury: Development, Implementation, and Characterization SO JOURNAL OF NEUROTRAUMA LA English DT Article DE biomarker; brain injury; closed-head injury; concussion; mild traumatic projectile concussive impact; motor function; rat helmet ID PROFESSIONAL FOOTBALL; COGNITIVE DEFICITS; BIOMECHANICS; IMPACT AB Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). While single concussions result in short-term neurologic dysfunction, multiple concussions can result in cumulative damage and increased risk for neurodegenerative disease. Despite the prevalence of concussion, knowledge about what occurs in the brain following this injury is limited, in part due to the limited number of appropriate animal research models. To study clinically relevant concussion we recently developed a simple, non-invasive rodent model of closed-head projectile concussive impact (PCI) TBI. For this purpose, anesthetized rats were placed on a platform positioned above a torque-sealed microcentrifuge tube packed with fixed amounts of dry ice. Upon heating, rapid sublimation of the dry ice produced a build-up of compressed CO2 that triggered an eruptive force causing the cap to launch as an intact projectile, resulting in a targeted PCI head injury. A stainless steel helmet was implemented to protect the head from bruising, yet allowing the brain to sustain a mild PCI event. Depending on the injury location and the application of the helmet, PCI-induced injuries ranged from severe (i.e., head injury with subdural hematomas, intracranial hemorrhage, and brain tissue damage), to mild (no head injury, intracranial hemorrhage, or gross morphological pathology). Although no gross pathology was evident in mild PCI-induced injury, the following protein changes and behavioral abnormalities were detected between 1 and 24h after PCI injury: (1) upregulation of glial fibrillary acidic protein (GFAP) in hippocampal regions; (2) upregulation of ubiquitin carboxyl-terminal hydrolase L1 (UCHL-1) in cortical tissue; and (3) significant sensorimotor abnormalities. Overall, these results indicated that this PCI model was capable of replicating salient pathologies of a clinical concussion, and could generate reproducible and quantifiable outcome measures. C1 [Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Tortella, FC (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Frank.Tortella@AMEDD.ARMY.MIL RI Shear, Deborah/B-3607-2011; Dave, Jitendra/A-8940-2011; Leung, Lai Yee/H-8204-2013 FU U.S. Army Medical Research and Materiel Command FX This work was supported by core funding provided by the U.S. Army Medical Research and Materiel Command, Combat Casualty Care Research Program. NR 21 TC 13 Z9 13 U1 0 U2 10 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JAN 20 PY 2012 VL 29 IS 2 BP 268 EP 280 DI 10.1089/neu.2011.2057 PG 13 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 885SO UT WOS:000299801300007 PM 21988140 ER PT J AU Shuka, MK Dubey, M Zakar, E Leszczynski, J AF Shuka, Manoj K. Dubey, Madan Zakar, Eugene Leszczynski, Jerzy TI Density Functional Theory Investigation of Electronic Structures and Properties of Ag-n-C-60-Ag-n Nanocontacts SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID C-60; BUCKMINSTERFULLERENE; CHEMISTRY; EXCHANGE; SURFACE; METALS AB Electronic structures and properties of nanocontacts involving the Ag-n-C-60-Ag-n system were explored. Molecular geometries of the studied species were optimized at the DFT level using the B3LYP functional and the 6-31G(d) basis set for carbon atoms and the LANL2DZ effective core potential (ECP) for the silver atoms. The C-60 was placed between the silver clusters of different sizes and the C-2h, symmetry was assumed in the calculations. In these complexes the top of the center of fused six-membered rings of C-60 interacted with silver clusters. Interaction energies between the silver clusters and C-60 were corrected for the basis set superposition error and were computed at the same theoretical level using various the 6-31G(d) and 6-311G(d) basis sets for carbon and LANL2DZ and Stuttgart RSC 1997 effective core potentials for the silver atoms. The obtained results were compared with those of the corresponding Au-n-C-60-Au-n systems obtained at the same theoretical level. It is expected that electronic structure at the interface will play an important role for the performance of nano devices. C1 [Shuka, Manoj K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisplinary Ctr Nanotox, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE RL, Adelphi, MD 20783 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Army Research Laboratory BAA [DAAD19-03-R-0017, 2.41, W911QX-07-C-0100]; NSF-CREST [HRD-0833178] FX J.L. is thankful to financial support from Army Research Laboratory BAA# DAAD19-03-R-0017, section No. 2.41, Contract No. W911QX-07-C-0100, and NSF-CREST grant No. HRD-0833178 and the Mississippi Center for Supercomputing Research (MCSR) for the generous computational facility. NR 27 TC 5 Z9 5 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 19 PY 2012 VL 116 IS 2 BP 1966 EP 1972 DI 10.1021/jp209054k PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 882SS UT WOS:000299584800040 ER PT J AU Nilakantan, G Keefe, M Wetzel, ED Bogetti, TA Gillespie, JW AF Nilakantan, Gaurav Keefe, Michael Wetzel, Eric D. Bogetti, Travis A. Gillespie, John W., Jr. TI Effect of statistical yarn tensile strength on the probabilistic impact response of woven fabrics SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE Aramid fiber; Flexible composites; Impact behavior; Finite element analysis (FEA); Probabilistic methods ID BALLISTIC IMPACT; FRICTION; ARMOR AB The probabilistic impact response of flexible woven fabrics can be described through the V-0-V-100 or probabilistic velocity response (PVR) curve which describes the probability of fabric penetration as a function of projectile impact velocity. One source of variability that affects the probabilistic nature of fabric impact performance is the statistical distribution of yarn tensile strengths. In this paper the effects of the statistical yarn strength distribution characteristics on the probabilistic fabric impact response are computationally studied using five different strength distributions with differing mean strengths and distribution widths. Corresponding fabric PVR curves are generated for each strength distribution using a probabilistic computational framework that involves randomly mapping yarn strengths onto the individual woven yarns of a fabric finite element model and then running a series of impact simulations for the case of a four-sided clamped fabric impacted at the center by a spherical projectile. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Nilakantan, Gaurav; Keefe, Michael; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Gillespie, John W., Jr.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. [Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Wetzel, Eric D.; Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Gillespie, JW (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. EM gillespi@udel.edu RI Nilakantan, Gaurav/B-8643-2012 OI Nilakantan, Gaurav/0000-0002-5375-9681 FU Army Research Laboratory [W911NF-06-2-0011] FX This research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-06-2-0011. The views and conclusions contained in this document are those of the authors and should not be interested as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 19 TC 8 Z9 8 U1 2 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 EI 1879-1050 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD JAN 18 PY 2012 VL 72 IS 2 BP 320 EP 329 DI 10.1016/j.compscitech.2011.11.021 PG 10 WC Materials Science, Composites SC Materials Science GA 897JW UT WOS:000300648000026 ER PT J AU Zollinger, WD Babcock, JG Moran, EE Brandt, BL Matyas, GR Wassef, NM Alving, CR AF Zollinger, Wendell D. Babcock, Janiine G. Moran, Elizabeth E. Brandt, Brenda L. Matyas, Gary R. Wassef, Nabila M. Alving, Carl R. TI Phase I study of a Neisseria meningitidis liposomal vaccine containing purified outer membrane proteins and detoxified lipooligosaccharide SO VACCINE LA English DT Article DE Neisseria meningitidis; Vaccine; Liposome; Lipooligosaccharide; Human ID BACTERICIDAL IMMUNE-RESPONSE; B MENINGOCOCCAL DISEASE; VESICLE VACCINE; IMMUNOGENICITY; LIPOPOLYSACCHARIDE; EFFICACY; SAFETY; IMMUNIZATION; EXPRESSION; ANTIBODIES AB Purified outer membrane proteins and purified deacylated lipooligosaccharide (dLOS) were formulated for use as a vaccine in three formulations for clinical use. The three vaccine formulations included (1) purified outer membrane proteins (OMPs) and L8-5 dLOS adsorbed to aluminum hydroxide; (2) purified OMPs and L8-5 dLOS incorporated into liposomes; and (3) purified OMPs and L7 dLOS incorporated into proteoliposomes. The vaccines were compared for immunogenicity and safety in a phase 1clinical study. Ten adult volunteers were vaccinated with each of the three vaccine formulations. Two 50 mu g doses were given six weeks apart, and serum samples were obtained at 0, 2, 6, 8 and 14 weeks. Volunteers were evaluated for reactogenicity 30 min after vaccination and at days 1, 2, and 14 after each vaccination, and laboratory safety tests were done at 0, 2 and 6 weeks. Overall, the vaccines were well tolerated. Bactericidal assays against a homologous strain showed a four-fold or greater increase in titer in 6 of 7 volunteers in group one, 9 of 10 volunteers in group two, and 5 of 10 volunteers in group three. A quantitative enzyme linked immunosorbant assay showed increases in antibody against both OMPs and LOS antigens. The liposome formulation appeared to be particularly effective in presenting the dLOS as an antigen. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Zollinger, Wendell D.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Zollinger, WD (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM wendell.zollinger@us.army.mil OI Matyas, Gary/0000-0002-2074-2373 FU U.S. Army FX The study was done with approval and funding from the U.S. Army Medical Infectious Disease Research Program. NR 43 TC 8 Z9 8 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 17 PY 2012 VL 30 IS 4 BP 712 EP 721 DI 10.1016/j.vaccine.2011.11.084 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 892CG UT WOS:000300263700004 PM 22138211 ER PT J AU Duderstadt, SK Rose, CE Real, TM Sabatier, JF Stewart, B Ma, GH Yerubandi, UD Eick, AA Tokars, JI McNeil, MM AF Duderstadt, Susan K. Rose, Charles E., Jr. Real, Theresa M. Sabatier, Jennifer F. Stewart, Brock Ma, Guihua Yerubandi, Uma D. Eick, Angelia A. Tokars, Jerome I. McNeil, Michael M. TI Vaccination and risk of type 1 diabetes mellitus in active component US Military, 2002-2008 SO VACCINE LA English DT Article DE Type 1 diabetes mellitus; Adult vaccination; Vaccine safety ID MEDICAL SURVEILLANCE SYSTEM; VITAMIN-D STATUS; YOUNG-ADULTS; CHILDHOOD; CHILDREN; IMMUNIZATION; PREVALENCE; EPIDEMIOLOGY; ASSOCIATION; INFECTIONS AB Aims/hypothesis: To evaluate whether vaccination increases the risk of type 1 diabetes mellitus in active component U.S. military personnel. Methods: We conducted a retrospective cohort study among active component U.S. military personnel age 17-35 years. Individuals with first time diagnoses of type 1 diabetes between January 1, 2002 and December 31, 2008 were identified using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. We used Poisson regression to estimate risk ratios between individual vaccine exposures and type 1 diabetes. Secondary analyses were performed controlling for receipt of multiple vaccines and available demographic variables. Results: Our study population consisted of 2,385,102 individuals followed for approximately 7,644,098 person-years of service. This included 1074 incident type 1 diabetes cases. We observed no significant increased risk of type 1 diabetes after vaccination with anthrax vaccine adsorbed (AVA) [RR = 1.00; 95% CI (0.85, 1.17)], smallpox vaccine [RR= 0.84; 95% (CI 0.70, 1.01)], typhoid vaccine [RR= 1.03; 95% CI (0.87, 1.22)], hepatitis B vaccine [RR= 0.83; 95% CI (0.72, 0.95)], measles mumps rubella vaccine (MMR) [RR= 0.71.95% CI (0.61, 0.83)], or yellow fever vaccine [RR = 0.70; 95% CI (0.59, 0.82)]. Conclusions: We did not find an increased risk of diagnosed type 1 diabetes and any of the study vaccines. We recommend that follow-up studies using medical record review to confirm case status should be considered to corroborate these findings. Published by Elsevier Ltd. C1 [Sabatier, Jennifer F.] Ctr Dis Control & Prevent, Ctr Global Hlth, Div Global HIV AIDS, Atlanta, GA USA. [Stewart, Brock] Sci Applicat Int Corp, Mclean, VA 22102 USA. [Eick, Angelia A.] USA, Ctr Hlth Promot & Prevent Med, Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. RP McNeil, MM (reprint author), CDC, 1600 Clifton Rd NE,MS D-26, Atlanta, GA 30333 USA. EM mmm2@cdc.gov NR 50 TC 7 Z9 7 U1 2 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 17 PY 2012 VL 30 IS 4 BP 813 EP 819 DI 10.1016/j.vaccine.2011.10.087 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 892CG UT WOS:000300263700016 PM 22075092 ER PT J AU Livi, KJT Lafferty, B Zhu, MQ Zhang, SL Gaillot, AC Sparks, DL AF Livi, Kenneth J. T. Lafferty, Brandon Zhu, Mengqiang Zhang, Shouliang Gaillot, Anne-Claire Sparks, Donald L. TI Electron Energy-Loss Safe-Dose Limits for Manganese Valence Measurements in Environmentally Relevant Manganese Oxides SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LOSS SPECTROSCOPY; OXIDATION-STATES; MN-OXIDES; MINERALS; BIRNESSITE; REDUCTION; IRON; EELS; FE AB Manganese (Mn) oxides are among the strongest mineral oxidants in the environment and impose significant influence on mobility and bioavailability of redox-active substances, such as arsenic, chromium, and pharmaceutical products, through oxidation processes. Oxidizing potentials of Mn oxides are determined by Mn valence states (2+, 3+, 4+). In this study, the effects of beam damage during electron energy-loss spectroscopy (EELS) in the transmission electron microscope have been investigated to determine the "safe dose" of electrons. Time series analyses determined the safe dose fluence (electrons/nm(2)) for todorokite (10(6) e/nm(2)), acid birnessite (10(5)), triclinic birnessite (10(4)), randomly stacked birnessite (10(3)), and (delta-MnO2 (<10(3)) at 200 kV. The results show that meaningful estimates of the mean Mn valence can be acquired by EELS if proper care is taken. C1 [Livi, Kenneth J. T.] Johns Hopkins Univ, Dept Earth & Planetary Sci, Integrated Imaging Ctr, High Resolut Analyt Electron Microbeam Facil, Baltimore, MD 21218 USA. [Livi, Kenneth J. T.] Johns Hopkins Univ, Dept Biol, Integrated Imaging Ctr, High Resolut Analyt Electron Microbeam Facil, Baltimore, MD 21218 USA. [Lafferty, Brandon; Zhu, Mengqiang; Sparks, Donald L.] Univ Delaware, Newark, DE 19717 USA. [Lafferty, Brandon] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Zhang, Shouliang] Univ Texas Austin, Texas Mat Inst, Austin, TX 78712 USA. [Gaillot, Anne-Claire] Univ Nantes, CNRS, Inst Mat Jean Rouxel IMN, F-44322 Nantes 3, France. RP Livi, KJT (reprint author), Johns Hopkins Univ, Dept Earth & Planetary Sci, Integrated Imaging Ctr, High Resolut Analyt Electron Microbeam Facil, Baltimore, MD 21218 USA. EM klivi@jhu.edu RI Zhu, Mengqiang/G-6614-2011 OI Zhu, Mengqiang/0000-0001-7963-7167 FU National Science Foundation EPSCoR [EPS-0814251]; NSF EAR [0544246]; State of Delaware FX This publication was made possible by the National Science Foundation EPSCoR Grant No. EPS-0814251, NSF EAR Grant No. 0544246 and the State of Delaware. NR 28 TC 9 Z9 9 U1 4 U2 37 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 17 PY 2012 VL 46 IS 2 BP 970 EP 976 DI 10.1021/es203516h PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 876VQ UT WOS:000299136200053 PM 22148625 ER PT J AU Gong, P Guan, X Pirooznia, M Liang, C Perkins, EJ AF Gong, Ping Guan, Xin Pirooznia, Mehdi Liang, Chun Perkins, Edward J. TI Gene Expression Analysis of CL-20-Induced Reversible Neurotoxicity Reveals GABA(A) Receptors as Potential Targets in the Earthworm Eisenia fetida SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID NICOTINIC ACETYLCHOLINE-RECEPTOR; CAENORHABDITIS-ELEGANS; BODY-WALL; LUMBRICUS-TERRESTRIS; FATHEAD MINNOW; RAT-BRAIN; RDX; FOETIDA; CL-20; ECOTOXICOGENOMICS AB The earthworm Eisenia fetida is one of the most used species in standardized soil ecotoxicity tests. End points such as survival, growth, and reproduction are eco-toxicologically relevant but provide little mechanistic insight into toxicity pathways, especially at the molecular level. Here we apply a toxicogenomic approach to investigate the mode of action underlying the reversible neurotoxicity of hexanitrohexaazaisowurtzitane (CL-20), a cyclic nitroamine explosives compound. We developed an E. fetida-specific shotgun microarray targeting 15119 unique E. fetida transcripts. Using this array we profiled gene expression in E. fetida in response to exposure to CL-20. Eighteen earthworms were exposed for 6 days to 0.2 mu g/cm(2) of CL-20 on filter paper, half of which were allowed to recover in a clean environment for 7 days. Nine vehicle control earthworms were sacrificed at days 6 and 13, separately. Electrophysiological measurements indicated that the conduction velocity of earthworm medial giant nerve fiber decreased significantly after 6-day exposure to CL-20, but was restored after 7 days of recovery. Total RNA was isolated from the four treatment groups including 6-day control, 6-day exposed, 13-day control, and 13-day exposed (i.e., 6-day exposure followed by 7-day recovery), and was hybridized to the 15K shotgun oligo array. Statistical and bioinformatic analyses suggest that CL-20 initiated neurotoxicity by noncompetitively blocking the ligand-gated GABA(A) receptor ion channel, leading to altered expression of genes involved in GABAergic, cholinergic, and Agrin-MuSK pathways. In the recovery phase, expression of affected genes returned to normality, possibly as a result of autophagy and CL-20 dissociation/metabolism. This study provides significant insights into potential mechanisms of CL-20-induced neurotoxicity and the recovery of earthworms from transient neurotoxicity stress. C1 [Gong, Ping; Guan, Xin] SpecPro Inc, Environm Serv, San Antonio, TX 78216 USA. [Pirooznia, Mehdi] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA. [Liang, Chun] Miami Univ, Dept Bot, Oxford, OH 45056 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), SpecPro Inc, Environm Serv, San Antonio, TX 78216 USA. EM ping.gong@usace.army.mil OI Pirooznia, Mehdi/0000-0002-4210-6458 FU U.S. Army FX We thank Robert E. Boyd, Willie Brown, and B. Lynn Escalon for their technical assistance. Permission was granted by the Chief of Engineers to publish this information. This work was supported by the U.S. Army Environmental Quality/Installation Basic Research Program. NR 58 TC 5 Z9 5 U1 2 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 17 PY 2012 VL 46 IS 2 BP 1223 EP 1232 DI 10.1021/es203642e PG 10 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 876VQ UT WOS:000299136200084 PM 22191394 ER PT J AU Mattiucci, N D'Aguanno, G Everitt, HO Foreman, JV Callahan, JM Buncick, MC Bloemer, MJ AF Mattiucci, Nadia D'Aguanno, Giuseppe Everitt, Henry O. Foreman, John V. Callahan, John M. Buncick, Milan C. Bloemer, Mark J. TI Ultraviolet surface-enhanced Raman scattering at the plasmonic band edge of a metallic grating SO OPTICS EXPRESS LA English DT Article ID SILVER ELECTRODE; RESONANCE RAMAN; SPECTROSCOPY; CHEMISTRY; PYRIDINE; SPECTRA AB Surface-enhanced Raman Scattering (SERS) is studied in subwavelength metallic gratings on a substrate using a rigorous electromagnetic approach. In the ultraviolet SERS is limited by the metallic dampening, yet enhancements as large as 10(5) are predicted. It is shown that these enhancements are directly linked to the spectral position of the plasmonic band edge of the metal/substrate surface plasmon. A simple methodology is presented for selecting the grating pitch to produce optimal enhancement for a given laser frequency. (C)2012 Optical Society of America C1 [Mattiucci, Nadia; D'Aguanno, Giuseppe; Callahan, John M.; Buncick, Milan C.] AEgis Tech, Nanogenesis Div, Huntsville, AL 35806 USA. [Everitt, Henry O.; Foreman, John V.; Bloemer, Mark J.] USA, Aviat & Missile Res Dev & Engn Ctr, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA. RP Mattiucci, N (reprint author), AEgis Tech, Nanogenesis Div, 410 Jan Davis Dr, Huntsville, AL 35806 USA. EM giuseppe.daguanno@us.army.mil RI Everitt, Henry/L-7118-2013; OI Everitt, Henry/0000-0002-8141-3768; D'Aguanno, Giuseppe/0000-0002-7132-0103 FU DARPA SBIR [W31P4Q-11-C-0109] FX N.M., G.D. and M.C.B. acknowledge financial support from DARPA SBIR project "Nonlinear Plasmonic Devices" contract number W31P4Q-11-C-0109. NR 29 TC 21 Z9 21 U1 2 U2 37 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JAN 16 PY 2012 VL 20 IS 2 BP 1868 EP 1877 DI 10.1364/OE.20.001868 PG 10 WC Optics SC Optics GA 889EZ UT WOS:000300057700117 PM 22274532 ER PT J AU Nakamura, YK Dubick, MA Omaye, ST AF Nakamura, Yukiko K. Dubick, Michael A. Omaye, Stanley T. TI gamma-Glutamylcysteine inhibits oxidative stress in human endothelial cells SO LIFE SCIENCES LA English DT Article DE gamma-Glutamylcysteine; Glutathione; Glutathione synthetase; Oxidative stress ID NF-KAPPA-B; GLUTATHIONE SYNTHETASE; GENE-EXPRESSION; ACID; INJURY; TRANSCRIPTION; ACCUMULATION; MECHANISMS; PROTEIN-1; INDUCTION AB Aims: gamma-Glutamylcysteine (GGC) is a dipeptide and substrate for synthesis of the antioxidant glutathione (GSH), whose health promoting properties include reducing risks of oxidative stress-related injuries and diseases. The objective of this study was to investigate the efficacy of GGC on GSH synthesis and oxidative stress in human endothelial cells. Main methods: We assessed oxidative stress, GSH, GSH synthetase (GSS) expression, and transcription factor DNA binding levels in human umbilical vein endothelial cells (HUVEC). Key findings: We found significantly higher levels of PPAR gamma DNA binding and lower levels of GSH. GSS protein, NF-kappa B p65 DNA binding, thiobarbituric acid reactive substances (TBARS), and 8-epi-PGF(2 alpha) in a concentration-dependent manner, compared with the control. GSH and GSS protein levels showed a negative correlation with PPAR gamma DNA binding levels and positive correlation trends with NF-kappa B p65 DNA binding, TBARS, and 8-epi-PGF(2 alpha) levels. A putative binding site for NF-kappa B was found at 4 227 bases upstream from the transcription start site of GSS gene, but none for PPARs. These findings suggest the involvement of NF-kappa B in regulation of GSS expression. Subsequent GSH synthesis might be affected by the suppression of GSS expression in tested conditions. Significance: Besides its substrate role in GSH synthesis, GGC may play a role in protection against oxidative stress by serving as an antioxidant and modulating the expression of protein(s) related to antioxidant defense. Thus, we speculate that GGC may serve as a novel intra- and intercellular therapeutic dipeptide for oxidative stress-related injuries and diseases. (C) 2011 Elsevier Inc. All rights reserved. C1 [Nakamura, Yukiko K.; Omaye, Stanley T.] Univ Nevada, Dept Nutr, Reno, NV 89557 USA. [Dubick, Michael A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Omaye, ST (reprint author), 1664 N Virginia St, Reno, NV 89557 USA. EM omaye@unr.edu FU U.S. Army [USAMRMC09070005] FX This work was supported by federal funds from U.S. Army (USAMRMC09070005). NR 51 TC 6 Z9 6 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD JAN 16 PY 2012 VL 90 IS 3-4 BP 116 EP 121 DI 10.1016/j.lfs.2011.10.016 PG 6 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 882QX UT WOS:000299580100004 PM 22075492 ER PT J AU Yu, M Ma, XG Su, W Tung, L AF Yu, Ming Ma, Xiaoguang Su, Wei Tung, Leonard TI A new joint strategy of radio channel allocation and power control for wireless mesh networks SO COMPUTER COMMUNICATIONS LA English DT Article DE Wireless mesh network; MAC protocol; Radio channel allocation; Power control ID AD HOC NETWORKS; ASSIGNMENT; PROTOCOL; WLANS; MANAGEMENT; SCHEME AB For wireless mesh networks, it is critical to allocate the limited number of radio channels efficiently while mitigating the co-channel inference to improve network performance. For this reason, after extensively reviewing the related work, we present a new joint radio channel allocation (RCA) and power control (PC) strategy for wireless mesh networks. First, we formulate the RCA problem as a multiple objective optimization problem, with the constraints of transmission power and traffic data rates, while effective channel utilization (ECU) is chosen as the target metric for optimization. Second, we incorporate the channel status into the model of MAC protocols, including as signal-to-noise ratio (SNR) and transmission power. Consequently, the PC is incorporated into the ECU for channel allocation. Third, we propose to directly maximize the ECU to find both optimal radio channel and transmission power. The resulting strategy is a fully distributed RCA/PC algorithm without relying on a coordination mechanism among mesh routers. Our extensive simulation results have demonstrated that the proposed algorithm significantly outperforms the existing RCA strategies and the standard MAC protocols in performance such as throughput, packet dropping, delay and delay jitter. (C) 2011 Elsevier B.V. All rights reserved. C1 [Yu, Ming; Ma, Xiaoguang; Tung, Leonard] Florida State Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. [Su, Wei] USA, Res Labs, RDECOM, CERDEC, Ft Monmouth, NJ 07703 USA. RP Yu, M (reprint author), Florida State Univ, Dept Elect & Comp Engn, Tallahassee, FL 32310 USA. EM mingyu@eng.fsu.edu NR 29 TC 5 Z9 5 U1 0 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0140-3664 J9 COMPUT COMMUN JI Comput. Commun. PD JAN 15 PY 2012 VL 35 IS 2 BP 196 EP 206 DI 10.1016/j.comcom.2011.09.010 PG 11 WC Computer Science, Information Systems; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA 896UL UT WOS:000300596800006 ER PT J AU Joshi, RP Sridhara, V Shah, P del Rosario, RD AF Joshi, R. P. Sridhara, V. Shah, P. del Rosario, R. D. TI Monte Carlo analysis of GaN-based Gunn oscillators for microwave power generation (vol 93, pg 4836, 2003) SO JOURNAL OF APPLIED PHYSICS LA English DT Correction C1 [Joshi, R. P.; Sridhara, V.] Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA. [Shah, P.; del Rosario, R. D.] USA, Res Lab, Adelphi, MD 20783 USA. RP Joshi, RP (reprint author), Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA. EM rjoshi@odu.edu NR 1 TC 0 Z9 0 U1 1 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 2012 VL 111 IS 2 AR 029904 DI 10.1063/1.3676649 PG 1 WC Physics, Applied SC Physics GA 885PX UT WOS:000299792400113 ER PT J AU Joshi, RP Sridhara, V Jogai, B Shah, P del Rosario, RD AF Joshi, R. P. Sridhara, V. Jogai, B. Shah, P. del Rosario, R. D. TI Analysis of dislocation scattering on electron mobility in GaN high electron mobility transistors (vol 93, pg 10046, 2003) SO JOURNAL OF APPLIED PHYSICS LA English DT Correction C1 [Joshi, R. P.; Sridhara, V.] Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA. [Jogai, B.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Jogai, B.] Wright State Univ, Semicond Res Ctr, Dayton, OH 45435 USA. [Shah, P.; del Rosario, R. D.] USA, Res Lab, Adelphi, MD 20783 USA. RP Joshi, RP (reprint author), Old Dominion Univ, Dept Elect & Comp Engn, Norfolk, VA 23529 USA. EM rjoshi@odu.edu NR 1 TC 0 Z9 0 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 2012 VL 111 IS 2 AR 029901 DI 10.1063/1.3679426 PG 1 WC Physics, Applied SC Physics GA 885PX UT WOS:000299792400110 ER PT J AU Deye, GA Miller, RS Miller, L Salas, CJ Tosh, D Macareo, L Smith, BL Fracisco, S Clemens, EG Murphy, J Sousa, JC Dumler, JS Magill, AJ AF Deye, Gregory A. Miller, R. Scott Miller, Lori Salas, Carola J. Tosh, Donna Macareo, Louis Smith, Bryan L. Fracisco, Susan Clemens, Emily G. Murphy, Jittawadee Sousa, Jason C. Dumler, J. Stephen Magill, Alan J. TI Prolonged Protection Provided by a Single Dose of Atovaquone-Proguanil for the Chemoprophylaxis of Plasmodium falciparum Malaria in a Human Challenge Model SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID PLACEBO-CONTROLLED TRIAL; CYTOCHROME-B; IN-VITRO; PROPHYLAXIS; SURVEILLANCE; AZITHROMYCIN; VOLUNTEERS; PREVENTION; RESISTANCE; INDONESIA AB Background. We conducted a randomized, placebo-controlled, double-blind trial to establish the efficacy of atovaquone-proguanil to prevent malaria with the goal of simulating weekly dosing in a human Plasmodium falciparum challenge model. Methods. Thirty volunteers randomly received 1 of the following dose regimens: (1) 250 milligrams of atovaquone and 100 milligrams of proguanil (250/100 milligrams) 1 day prior to infectious mosquito challenge (day -1), (2) 250/100 milligrams on day 4 after challenge, (3) 250/100 milligrams on day -7, (4) 500 milligrams of atovaquone and 200 milligrams of proguanil (500/200 milligrams) on day -7 or, (5) 1000 milligrams of atovaquone and 400 milligrams of proguanil (1000/400 milligrams) on day -7. All regimens included matching placebo such that all volunteers received identical pill numbers. Six volunteers served as open-label infectivity controls. Volunteers underwent mosquito sporozoite challenge with P. falciparum 3D7 strain. Follow-up consisted of serial microscopy and close clinical monitoring for 90 days. Results. Six of 6 infectivity controls developed parasitemia as expected. Two of 5 evaluable volunteers receiving 250/100 milligrams 7 days prior to challenge and 1 of 6 volunteers receiving 1000/400 milligrams 7 days prior to challenge were microscopically diagnosed with malaria. All other volunteers were protected. Atovaquone exposure (area under the curve) during liver stage development was low in 2 of 3 volunteers with prophylactic failure (423 and 199 ng/mL x days compared with a mean for protected volunteers of 1903 ng/mL x days), as was peak concentration (165 and 81 ng/mL compared with a mean of 594 ng/mL in volunteers with prophylactic success). Elimination half-life was short in volunteers with prophylactic failure (2.4, 2.0, and 3.3 days compared with a mean of 4.1 days in volunteers with prophylactic success). Conclusions. Single-dose atovaquone-proguanil provides effective malaria chemoprophylaxis against P. falciparum challenge at dosing intervals supportive of weekly dosing. Postexposure prophylaxis 4 days after challenge was 100% effective. C1 [Deye, Gregory A.; Miller, R. Scott; Macareo, Louis; Smith, Bryan L.; Fracisco, Susan; Sousa, Jason C.; Magill, Alan J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Miller, Lori; Tosh, Donna] Walter Reed Army Inst Res, Clin Trials Ctr, Silver Spring, MD 20910 USA. [Murphy, Jittawadee] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Salas, Carola J.] Naval Med Res Unit 6, Lima, Peru. [Clemens, Emily G.; Dumler, J. Stephen] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA. RP Deye, GA (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM gregory.deye@gmail.com RI Sousa, Jason/A-9177-2011 FU Military Infectious Disease Research Program; United States Army FX Military Infectious Disease Research Program; United States Army Medical Materiel Development Activity. NR 24 TC 11 Z9 11 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JAN 15 PY 2012 VL 54 IS 2 BP 232 EP 239 DI 10.1093/cid/cir770 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866LZ UT WOS:000298383700013 PM 22052893 ER PT J AU Mitasova, H Harmon, RS Weaver, KJ Lyons, NJ Overton, MF AF Mitasova, Helena Harmon, Russell S. Weaver, Katherine J. Lyons, Nathan J. Overton, Margery F. TI Scientific visualization of landscapes and landforms SO GEOMORPHOLOGY LA English DT Article DE Relief shading; DEM time series; LiDAR; Tangible geospatial modeling; GRASS GIS ID DIGITAL ELEVATION MODELS; GRASS GIS; GEOMORPHOLOGY; ENVIRONMENT; CARTOGRAPHY; CLOUDS AB Scientific visualization of geospatial data provides highly effective tools for analysis and communication of information about the land surface and its features, properties, and temporal evolution. Whereas single-surface visualization of landscapes is now routinely used in presentation of Earth surface data, interactive 3D visualization based upon multiple elevation surfaces and cutting planes is gaining recognition as a powerful tool for analyzing landscape structure based on multiple return Light Detection and Ranging (LiDAR) data. This approach also provides valuable insights into land surface changes captured by multi-temporal elevation models. Thus, animations using 2D images and 3D views are becoming essential for communicating results of landscape monitoring and computer simulations of Earth processes. Multiple surfaces and 3D animations are also used to introduce novel concepts for visual analysis of terrain models derived from time-series of LiDAR data using multi-year core and envelope surfaces. Analysis of terrain evolution using voxel models and visualization of contour evolution using isosurfaces has potential for unique insights into geometric properties of rapidly evolving coastal landscapes. In addition to visualization on desktop computers, the coupling of GIS with new types of graphics hardware systems provides opportunities for cutting-edge applications of visualization for geomorphological research. These systems include tangible environments that facilitate intuitive 3D perception, interaction and collaboration. Application of the presented visualization techniques as supporting tools for analyses of landform evolution using airborne LiDAR data and open source geospatial software is illustrated by two case studies from North Carolina, USA. (C) 2011 Elsevier B.V. All rights reserved. C1 [Mitasova, Helena; Weaver, Katherine J.; Lyons, Nathan J.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. [Overton, Margery F.] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Harmon, Russell S.] USA, Div Environm Sci, Army Res Off, Res Lab, Durham, NC 27703 USA. RP Mitasova, H (reprint author), N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Box 8208, Raleigh, NC 27695 USA. EM hmitaso@unity.ncsu.edu; russell.harmon@us.army.mil; overton@ncsu.edu RI Lyons, Nathan/K-2388-2013; OI Lyons, Nathan/0000-0001-6965-3374; Mitasova, Helena/0000-0002-6906-3398 FU US Army Research Office; North Carolina Sea FX The authors would like to gratefully acknowledge the funding support from the US Army Research Office and North Carolina Sea Grant as well as the free access to the LiDAR data provided by the United States Geological Survey, US Army Corps of Engineers, North Carolina Floodplain Mapping Program and the National Oceanic and Atmospheric Administration Coastal Services Center. NR 49 TC 14 Z9 14 U1 1 U2 63 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-555X J9 GEOMORPHOLOGY JI Geomorphology PD JAN 15 PY 2012 VL 137 IS 1 SI SI BP 122 EP 137 DI 10.1016/j.geomorph.2010.09.033 PG 16 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 868GN UT WOS:000298511800010 ER PT J AU Chun, HM Roediger, MP Hullsiek, KH Thio, CL Agan, BK Bradley, WP Peel, SA Jagodzinski, LL Weintrob, AC Ganesan, A Wortmann, G Crum-Cianflone, NF Maguire, JD Landrum, ML AF Chun, Helen M. Roediger, Mollie P. Hullsiek, Katherine Huppler Thio, Chloe L. Agan, Brian K. Bradley, William P. Peel, Sheila A. Jagodzinski, Linda L. Weintrob, Amy C. Ganesan, Anuradha Wortmann, Glenn Crum-Cianflone, Nancy F. Maguire, Jason D. Landrum, Michael L. CA Infect Dis Clinical Res Program TI Hepatitis B Virus Coinfection Negatively Impacts HIV Outcomes in HIV Seroconverters SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; T-CELL RESPONSES; ACTIVE ANTIRETROVIRAL THERAPY; C-VIRUS; HOMOSEXUAL-MEN; RAPID PROGRESSION; INFECTED PATIENTS; NATURAL-HISTORY; AIDS; INDIVIDUALS AB Background. Understanding the impact of hepatitis B virus (HBV) in human immunodeficiency virus (HIV) coinfection has been limited by heterogeneity of HIV disease. We evaluated HBV coinfection and HIV-related disease progression in a cohort of HIV seroconverters. Methods. Participants with HIV diagnosis seroconversion window of < 3 years and serologically confirmed HBV infection (HB) status were classified at baseline into 4 HB groups. The risk of clinical AIDS/death in HIV seroconverters was calculated by HB status. Results. Of 2352 HIV seroconverters, 474 (20%) had resolved HB, 82 (3%) had isolated total antibody to hepatitis B core antigen (HBcAb), and 64 (3%) had chronic HB. Unadjusted rates (95% confidence intervals [CIs]) of clinical AIDS/death for the HB-negative, resolved HB, isolated HBcAb, and chronic HB groups were 2.43 (2.15-2.71); 3.27 (2.71-3.84); 3.75 (2.25-5.25); and 5.41 (3.41-7.42), respectively. The multivariable risk of clinical AIDS/death was significantly higher in the chronic HB group compared to the HB-negative group (hazard ratio [HR], 1.80; 95% CI, 1.20-2.69); while the HRs were increased but nonsignificant for those with resolved HB (HR, 1.17; 95% CI, .94-1.46) and isolated HBcAb (HR, 1.14; 95% CI, .75-1.75). Conclusions. HBV coinfection has a significant impact on HIV outcomes. The hazard for an AIDS or death event is almost double for those with chronic HB compared, with HIV-monoinfected persons. C1 [Chun, Helen M.; Roediger, Mollie P.; Hullsiek, Katherine Huppler; Agan, Brian K.; Bradley, William P.; Peel, Sheila A.; Jagodzinski, Linda L.; Weintrob, Amy C.; Ganesan, Anuradha; Wortmann, Glenn; Crum-Cianflone, Nancy F.; Maguire, Jason D.; Landrum, Michael L.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Thio, Chloe L.] Johns Hopkins Univ, Div Infect Dis, Baltimore, MD USA. [Peel, Sheila A.; Jagodzinski, Linda L.] Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD USA. [Chun, Helen M.] USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, San Diego, CA 92106 USA. [Crum-Cianflone, Nancy F.] USN, Infect Dis Clin, Med Ctr, San Diego, CA 92152 USA. [Roediger, Mollie P.; Hullsiek, Katherine Huppler] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy C.; Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Maguire, Jason D.] USN, Div Infect Dis, Med Ctr, Portsmouth, VA USA. [Landrum, Michael L.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. RP Chun, HM (reprint author), USN, Dept Def HIV AIDS Prevent Program, Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA. EM helen.chun@med.navy.mil OI Eberly, Lynn/0000-0003-4763-330X; Agan, Brian/0000-0002-5114-1669 FU Department of Defense through Uniformed Services University of the Health Sciences; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX This work was supported by the Infectious Disease Clinical Research Program (IDCRP; www.idcrp.org), a Department of Defense program executed through Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data and provided salary support to investigators (M. L. L., K. H. H., M. P. R., N. F. C., A. C. W., A. G., and B. K. A.). The analyses, conclusions, and decision to submit the manuscript are the independent work and decision of the authors. NR 43 TC 43 Z9 43 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 15 PY 2012 VL 205 IS 2 BP 185 EP 193 DI 10.1093/infdis/jir720 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866NN UT WOS:000298387900006 PM 22147794 ER PT J AU Kremsner, PG Taylor, T Issifou, S Kombila, M Chimalizeni, Y Kawaza, K Akotet, MKB Duscha, M Mordmuller, B Kosters, K Humberg, A Miller, RS Weina, P Duparc, S Mohrle, J Kun, JFJ Planche, T Teja-Isavadharm, P Simpson, JA Kohler, C Krishna, S AF Kremsner, Peter Gottfried Taylor, Terrie Issifou, Saadou Kombila, Maryvonne Chimalizeni, Yamikani Kawaza, Kondwana Akotet, Marielle K. Bouyou Duscha, Mattias Mordmueller, Benjamin Koesters, Katrin Humberg, Alexander Miller, R. Scott Weina, Peter Duparc, Stephan Moehrle, Joerg Kun, Juergen F. J. Planche, Tim Teja-Isavadharm, Paktiya Simpson, Julie Anne Koehler, Carsten Krishna, Sanjeev TI A Simplified Intravenous Artesunate Regimen for Severe Malaria SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SEVERE FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; RANDOMIZED-TRIAL; CHILDREN; QUININE; DIHYDROARTEMISININ AB Methods. This was a randomized, double-blind, placebo-controlled comparison to assess the noninferiority of a simplified 3-dose regimen (given at 0, 24, and 48 hours) compared with the conventional 5-dose regimen of intravenous artesunate (given at 0, 12, 24, 48, and 72 hours) in African children with Plasmodium falciparum malaria with a prespecified delta of 0.2. The total dose of artesunate in each group was 12 mg/kg. The primary end point was the proportion of children clearing >= 99% of their admission parasitemia at 24 hours. Safety data, secondary efficacy end points, and pharmacokinetics were also analyzed. Results. In 171 children (per protocol), 78% of the recipients (95% confidence interval [CI], 69%-87%) in the 3-dose group achieved >= 99% parasite clearance 24 hours after the start of treatment, compared with 85% (95% CI, 77%-93%) of those receiving the conventional regimen (treatment difference, -7.2%; 95% CI, -18.9% to 4.4%). Dihydroartemisinin was cleared slightly more slowly in those children receiving the higher 3-dose regimen (7.4 vs 8.8 L/h for a 13-kg child; P 5 .008). Conclusions. Pharmacodynamic analysis suggests that 3 doses of artesunate were not inferior to 5 doses for the treatment of severe malaria in children. Clinical Trials Registration. NCT00522132. C1 [Planche, Tim; Krishna, Sanjeev] St Georges Univ London, Ctr Infect, Div Clin Sci, London SW17 0RE, England. [Kremsner, Peter Gottfried; Issifou, Saadou; Duscha, Mattias; Mordmueller, Benjamin; Koesters, Katrin; Humberg, Alexander; Kun, Juergen F. J.; Koehler, Carsten] Univ Tubingen, Inst Tropenmed, D-72074 Tubingen, Germany. [Kremsner, Peter Gottfried; Issifou, Saadou; Duscha, Mattias; Mordmueller, Benjamin; Planche, Tim; Krishna, Sanjeev] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon. [Kombila, Maryvonne; Akotet, Marielle K. Bouyou] Fac Med & Sci Sante, Dept Parasitol Mycol & Med Trop, Libreville, Gabon. [Taylor, Terrie] Univ Malawi, Coll Med, Blantyre Malaria Project, Blantyre, Malawi. [Chimalizeni, Yamikani] Univ Malawi, Coll Med, Malawi Liverpool Wellcome Trust Clin Res Program, Blantyre, Malawi. [Kawaza, Kondwana] Queen Elizabeth Cent Hosp, Dept Pediat, Blantyre, Malawi. [Taylor, Terrie] Michigan State Univ, Coll Osteopath Med, E Lansing, MI 48824 USA. [Miller, R. Scott; Weina, Peter] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Duparc, Stephan; Moehrle, Joerg] Int Ctr Contrin, Geneva, Switzerland. [Teja-Isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Simpson, Julie Anne] Univ Melbourne, Sch Populat Hlth, Ctr MEGA Epidemiol, Melbourne, Vic 3010, Australia. RP Krishna, S (reprint author), St Georges Univ London, Ctr Infect, Div Clin Sci, London SW17 0RE, England. EM s.krishna@sgul.ac.uk RI Weina, Peter/A-2120-2011; OI Simpson, Julie/0000-0002-2660-2013; Krishna, Sanjeev/0000-0003-0066-0634 FU European Developing Countries Clinical Trials Partnership; German Federal Ministry of Education and Research; Medicines for Malaria Venture FX This work was supported by the European Developing Countries Clinical Trials Partnership, German Federal Ministry of Education and Research, and Medicines for Malaria Venture, which sponsored this study. NR 17 TC 16 Z9 16 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 15 PY 2012 VL 205 IS 2 BP 312 EP 319 DI 10.1093/infdis/jir724 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 866NN UT WOS:000298387900021 PM 22180622 ER PT J AU Murakami, Y Wei, G Yang, XF Lu, XCM Leung, LY Shear, DA Tortella, FC AF Murakami, Yuki Wei, Guo Yang, Xiaofang Lu, Xi-Chun May Leung, Lai Yee Shear, Deborah A. Tortella, Frank C. TI Brain oxygen tension monitoring following penetrating ballistic-like brain injury in rats SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Brain tissue oxygen tension (PbtO(2)); Hypoxia; Traumatic brain injury (TBI); Penetrating ballistic-like brain injury (PBBI); Fraction of inspired oxygen (FiO(2)) ID SEVERE HEAD-INJURY; NEAR-INFRARED SPECTROSCOPY; TRAUMATIC BRAIN; TISSUE OXYGEN; INTRACRANIAL-PRESSURE; NORMOBARIC HYPEROXIA; CEREBRAL-ISCHEMIA; NONCONVULSIVE SEIZURES; TEMPERATURE; VENTILATION AB While brain oxygen tension (PbtO(2)) monitoring is an important parameter for evaluating injury severity and therapeutic efficiency in severe traumatic brain injury (TBI) patients, many factors affect the monitoring. The goal of this study was to identify the effects of FiO(2) (fraction of inspired oxygen) on PbtO(2) in uninjured anesthetized rats and measure the changes in PbtO(2) following penetrating ballistic-like brain injury (PBBI). Continuous PbtO(2) monitoring in uninjured anesthetized rats showed that PbtO(2) response was positively correlated with FiO(2) (0.21-0.35) but PbtO(2) remained stable when FiO(2) was maintained at 0.26. Importantly, although increasing FiO(2) from 0.21 to 0.35 improved P(a)O(2), it concomitantly reduced pH levels and elevated P(a)CO(2) values out of the normal range. However, when the FiO(2) was maintained between 0.26 and 0.30, the pH and P(a)O(2) levels remained within the normal or clinically acceptable range. In PBBI rats, PbtO(2) was significantly reduced by 40% (16.9 +/- 1.2 mmHg) in the peri-lesional region immediately following unilateral, frontal 10% PBBI compared to sham rats (28.6 +/- 1.7 mmHg; mean SEM, p < 0.05) and the PBBI-induced reductions in PbtO(2) were sustained for at least 150 min post-PBBI. Collectively, these results demonstrate that FiO(2) affects PbtO(2) and that PBBI produces acute and sustained hypoxia in the peri-lesional region of the brain injury. This study provides important information for the management of PbtO(2) monitoring in this brain injury model and may offer insight for therapeutic strategies targeted to improve the hypoxia/ischemia state in the penetrating-type brain injury. Published by Elsevier B.V. C1 [Murakami, Yuki; Wei, Guo; Yang, Xiaofang; Lu, Xi-Chun May; Leung, Lai Yee; Shear, Deborah A.; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD 20910 USA. RP Wei, G (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM murakamiy@hs.med.kyoto-u.ac.jp; Guo.Wei@US.ARMY.MIL; Xiaofang.Yang@us.army.mil; may.lu@us.army.mil; laiyee.leung@us.army.mil; eborah.a.shear@us.army.mil; frank.c.tortella@us.army.mil RI Shear, Deborah/B-3607-2011; Leung, Lai Yee/H-8204-2013 FU U.S. Army Medical Research and Materiel Command FX This work was supported by core funding provided by the U.S. Army Medical Research and Materiel Command, combat Casualty Care Research Program. NR 57 TC 6 Z9 6 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD JAN 15 PY 2012 VL 203 IS 1 BP 115 EP 121 DI 10.1016/j.jneumeth.2011.09.025 PG 7 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 859SM UT WOS:000297896100013 PM 21983109 ER PT J AU Kim, H Ding, Y Kohl, PA AF Kim, Hyea Ding, Yi Kohl, Paul A. TI LiSICON - ionic liquid electrolyte for lithium ion battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Ionic liquids; Lisicon; Battery ID GRAPHITE-ELECTRODES; SOLID-ELECTROLYTE; IN-SITU; ANODES; TEMPERATURE; INTERFACE; GLASS AB Current lithium-ion batteries (LiB) have limited usefulness in high temperature applications due to the flammability of the organic electrolyte. Alternatively, solid electrolytes can mitigate safety issues and enable high temperature applications. Here, a new solid-state lithium ion battery design is investigated using LiSICON as the electrolyte. To reduce the interfacial resistance between the solid electrolyte and graphite electrode, an ionic liquid was used as the ionic conductor. N-propyl-N-methylpyrrolidinium bis(fluorosulfonyl)imide (PYR(13)(+)FSI(-)) was used as the ionic liquid due to its high efficiency for lithiation/delithiaion. The cell capacity and efficiency was measured at temperatures from 25 degrees C to 120 degrees C. The lithium salt concentration in the ionic liquid was found to change the electrolyte reduction potential. A stable solid electrolyte interface (SEI) was achieved by adjusting the lithium salt concentration in the wetting agent. Impedance spectroscopy was performed to study the cell behavior with different Li salt concentrations at elevated temperature. A carbon anode in a LiSICON cell with 0.75 M LiTFSI/PYR(13)(+)FSI(-) had a capacity of 325 mAh g(-1) and coulombic efficiency of 99.8% during cycling at 80 degrees C. (C) 2011 Elsevier B.V. All rights reserved. C1 [Kim, Hyea; Kohl, Paul A.] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. [Ding, Yi] USA, RDECOM TARDEC, AMSRD TAR R, Warren, MI 48397 USA. RP Kohl, PA (reprint author), Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA. EM kohl@gatech.edu FU Ceramatec Inc.; US Army, TARDEC FX The authors gratefully acknowledge the LiSICON donations from Ceramatec Inc., and the intellectual contribution of Dr. Chett Boxley. We also gratefully acknowledge the financial support of the US Army, TARDEC. NR 26 TC 16 Z9 16 U1 6 U2 77 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JAN 15 PY 2012 VL 198 BP 281 EP 286 DI 10.1016/j.jpowsour.2011.10.005 PG 6 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 859QK UT WOS:000297890700041 ER PT J AU Willis, MP Mantooth, BA Lalain, TA AF Willis, Matthew P. Mantooth, Brent A. Lalain, Teri A. TI Novel Methodology for the Estimation of Chemical Warfare Agent Mass Transport Dynamics, Part I: Evaporation SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID DRY BUILDING-MATERIALS; DROP EVAPORATION; SULFUR MUSTARD; DIFFUSION-COEFFICIENT; SESSILE DROPLET; VOC EMISSIONS; SIMULATION; SURFACES; EQUATION; SORPTION AB A novel contact angle experimental and computational methodology has been developed to estimate mass transport parameters for the evaporation of water and bis(2-chloroethyl) sulfide (distilled mustard, known as the chemical warfare agent HD) on homogeneous, impermeable, substrates of interest. The model uses a finite element technique to simulate the evaporation of a liquid droplet into air. A regression technique is applied to experimental contact angle data to determine the temperature-dependent mass transport parameters (i.e., the diffusivity of the agent in air). The technique predicted the diffusion coefficient for water in air within 1% at 40 degrees C. The methodology was used to evaluate the evaporation of HD into air at several temperatures, which may be used to develop accurate predictions for vapor emission hazards due to vapor-phase HD. Evaporation of liquid HD generates potential hazards to unprotected personnel. Modeling this process on nonsorptive substrates is the first step toward enable modeling contamination on absorptive substrates. The novel methodology can be applied to other chemicals and therefore may be implemented as a preliminary assessment of the chemicals' ability to evaporate, which can generate the potential for a chemical vapor hazard. The physics-based models, combined with the generated physical parameter values, enable the prediction of vapor emission hazards from the substrate. The application of this model is intended to simulate chemical warfare agents; however, it is applicable to any liquid on a surface. C1 [Willis, Matthew P.; Mantooth, Brent A.; Lalain, Teri A.] USA, Decontaminat Sci Branch, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Willis, MP (reprint author), USA, Decontaminat Sci Branch, Edgewood Chem & Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM matthew.p.willis.civ@mail.mil RI Mantooth, Brent/K-5559-2012; Willis, Matthew/K-8674-2012 OI Mantooth, Brent/0000-0001-6838-1741; Willis, Matthew/0000-0002-2938-8112 FU Defense Threat Reduction Agency (DTRA) [BA09MSB310] FX We would like to thank Mr. Eric Lowenstein at the Defense Threat Reduction Agency (DTRA) for funding this work under contact BA09MSB310. We would like to thank Abraham Greenstein for helpful discussions, Joseph Myers and Patricia Boone for experimental support, and Michelle Hover for program support. NR 29 TC 5 Z9 5 U1 2 U2 33 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 12 PY 2012 VL 116 IS 1 BP 538 EP 545 DI 10.1021/jp2087835 PG 8 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 874SP UT WOS:000298978700067 ER PT J AU Willis, MP Mantooth, BA Lalain, TA AF Willis, Matthew P. Mantooth, Brent A. Lalain, Teri A. TI Novel Methodology for the Estimation of Chemical Warfare Agent Mass Transport Dynamics. Part II: Absorption SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID SULFUR MUSTARD; SORPTION; DIFFUSION; COEFFICIENTS; PERMEATION; DROPLETS; SPREAD; LIQUID; BUTYL; FILMS AB A novel experimental and computational methodology has been developed for estimating Fickian mass transport parameters of organic molecules through stagnant mediums such as air, paints, or polymeric substrates. Dynamic contact angle experiments were performed to measure the droplet volume evolution with the chemical warfare agent bis(2-chloroethyl) sulfide (distilled mustard, known as the chemical warfare agent HD) on military-relevant substrates. A finite element model for simultaneous evaporation and absorption was used to analyze the experimental data and determine the mass transport parameter values of the agent in the absorptive material. The computational model was validated by comparison with the results of a complementary experimental technique involving testing for HD vapor emission from the contaminated material. The model predicted HD vapor emission rates from a silicone elastomer substrate for contamination conditions not directly tested. The simulation results show that the model parameters can be used to provide an accurate prediction of the absorbed mass and concentration distribution in the substrate at a range of environmental temperatures (20 to 50 degrees C) and contamination times (0 to infinite min). Predicting the absorbed mass in various substrate types and environmental conditions enables an accurate prediction of the resulting hazards from contaminated materials. C1 [Willis, Matthew P.; Mantooth, Brent A.; Lalain, Teri A.] USA, Decontaminat Sci Branch, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Willis, MP (reprint author), USA, Decontaminat Sci Branch, Edgewood Chem & Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM matthew.p.willis.civ@mail.mil RI Mantooth, Brent/K-5559-2012; Willis, Matthew/K-8674-2012 OI Mantooth, Brent/0000-0001-6838-1741; Willis, Matthew/0000-0002-2938-8112 FU Defense Threat Reduction Agency (DTRA) [BA09MSB310] FX We would like to thank Mr. Eric Lowenstein at the Defense Threat Reduction Agency (DTRA) for funding this work under contact BA09MSB310. We would like to thank Abraham Greenstein for helpful discussions, Joseph Myers and Patricia Boone for experimental support, and Michelle Hover for program support. NR 21 TC 3 Z9 3 U1 1 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 12 PY 2012 VL 116 IS 1 BP 546 EP 554 DI 10.1021/jp2087847 PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 874SP UT WOS:000298978700068 ER PT J AU Vatamanu, J Borodin, O Smith, GD AF Vatamanu, Jenel Borodin, Oleg Smith, Grant D. TI Molecular Dynamics Simulation Studies of the Structure of a Mixed Carbonate/LiPF6 Electrolyte near Graphite Surface as a Function of Electrode Potential SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID LITHIUM-ION BATTERIES; POLARIZABLE FORCE-FIELDS; THIN-FILM ELECTRODE; PROPYLENE CARBONATE; 2-DIMENSIONAL PERIODICITY; 3-DIMENSIONAL SYSTEMS; DIFFERENTIAL CAPACITANCE; RAPID CALCULATION; DOUBLE-LAYER; OXIDATIVE DECOMPOSITION AB Molecular dynamics (MD) simulations of an electrolyte comprised of ethylene carbonate (EC), dimethyl carbonate (DMC), and LiPF6 salt near the basal face of graphite electrodes have been performed as a function of electrode potential. Upon charging of the electrodes, the less polar DMC molecule is partially replaced in the interfacial electrolyte layer by the more polar EC. At negative potentials, the carbonyl groups from the carbonate molecules are repelled from the surface, while at positive potentials, we find a substantial enrichment of the surface with carbonyl groups. PF6- rapidly accumulates at the positive electrode with increasing potential and vacates the negative electrode with increasing negative potential. In contrast, Li+ concentration in the interfacial layer is found to be only weakly dependent on potential except at very large negative potentials. Hence, both composition of the electrolyte at the electrode surface and solvent environment around Li+ are observed to vary dramatically with the applied potential with important implications for oxidation/reduction of the electrolyte and the process of Li+ intercalation/deintercation. C1 [Vatamanu, Jenel; Smith, Grant D.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Borodin, Oleg] USA, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, 122 S Cent Campus Dr, Salt Lake City, UT 84112 USA. EM jenel.vatamanu@utah.edu RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012 OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608 FU Department of Energy [DE-AC02-05CH11231]; ABR DOE; University of Utah Center for High Performance Computing; DoD; Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]; [6838611] FX This work is supported by the Department of Energy through DE-AC02-05CH11231 grant on PO No. 6838611 to University of Utah and ABR DOE program. Support from the University of Utah Center for High Performance Computing and DoD's High Performance Computing Modernization Program's (HPCMP) Technology Insertion program is greatly acknowledged. This research used resources of the National Energy Research Scientific Computing Center, which is supported by the Office of Science of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. NR 79 TC 71 Z9 72 U1 7 U2 101 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JAN 12 PY 2012 VL 116 IS 1 BP 1114 EP 1121 DI 10.1021/jp2101539 PG 8 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 874SP UT WOS:000298978700137 ER PT J AU Chu-Agor, ML Munoz-Carpena, R Kiker, GA Aiello-Lammens, ME Akcakaya, HR Convertino, M Linkov, I AF Chu-Agor, M. L. Munoz-Carpena, R. Kiker, G. A. Aiello-Lammens, M. E. Akcakaya, H. R. Convertino, M. Linkov, I. TI Simulating the fate of Florida Snowy Plovers with sea-level rise: Exploring research and management priorities with a global uncertainty and sensitivity analysis perspective SO ECOLOGICAL MODELLING LA English DT Review DE Snowy Plover; Uncertainty analysis; Sensitivity analysis; Metapopulation; Monte Carlo filtering ID DETECTING DENSITY DEPENDENCE; METAPOPULATION MODELS; HUMAN DISTURBANCE; CLIMATE-CHANGE; HABITAT; VIABILITY; LANDSCAPE; SURVIVAL; CONNECTIVITY; CONSERVATION AB Changes in coastal habitats due to sea-level rise provide an uncertain, yet significant threat to shoreline dependent birds. Rising sea levels can cause habitat fragmentation and loss which can result in considerable reduction in their foraging and nesting areas. Computational models and their algorithmic assumptions play an integral role in exploring potential mitigation responses to uncertain and potentially adverse ecological outcomes. The presence of uncertainty in metapopulation models is widely acknowledged but seldom considered in their development and evaluation, specifically the effects of uncertain model inputs on the model outputs. This paper was aimed to (1) quantify the contribution of each uncertain input factor to the uncertainty in the output of a metapopulation model which evaluated the effects of long-term sea-level rise on the population of Snowy Plovers (Charadrius alexandrinus) found in the Gulf Coast of Florida, and (2) determine the ranges of model inputs that produced a specific output for the purpose of formulating environmental management decisions. This was carried out by employing global sensitivity and uncertainty analysis (GSA) using two generic (model independent) methods, the qualitative screening Morris method and a quantitative variance-based Sobol' method coupled with Monte Carlo filtering. The analyses were applied to three density dependence scenarios: assuming a ceiling-type density dependence, assuming a contest-type density dependence, and assuming that density dependence is uncertain as to being ceiling- or contest-dependent. The sources of uncertainty in the outputs depended strongly on the type of density dependence considered in the model. In general, uncertainty in the outputs highly depended on the uncertainty in stage matrix elements (fecundity, adult survival, and juvenile survival), dispersal rate from central areas with low current populations (the "Big Bend" area of Florida) to the northern, panhandle populations, the maximum growth rate, and density dependence type. Our results showed that increasing the maximum growth rate to a value of 1.2 or larger will increase the final average population of Snowy Plovers assuming a contest-type density dependence. Results suggest that studies that further quantify which density dependence relationship best describes Snowy Plover population dynamics should be conducted since this is the main driver of uncertainty in model outcomes. Furthermore, investigating the presence of Snowy Plovers in the Big Bend region may be important for providing connection between the panhandle and peninsula populations. (C) 2011 Elsevier BM. All rights reserved. C1 [Chu-Agor, M. L.; Munoz-Carpena, R.; Kiker, G. A.; Convertino, M.] Univ Florida, Dept Agr & Biol Engn, Gainesville, FL 32611 USA. [Aiello-Lammens, M. E.; Akcakaya, H. R.] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA. [Linkov, I.] USA, Engineer Res & Dev Ctr, Concord, MA 01366 USA. RP Munoz-Carpena, R (reprint author), Univ Florida, Dept Agr & Biol Engn, POB 110570, Gainesville, FL 32611 USA. EM carpena@ufl.edu RI Akcakaya, H. Resit/A-7830-2008; Munoz-Carpena, Rafael/A-7588-2010; OI Akcakaya, H. Resit/0000-0002-8679-5929; Munoz-Carpena, Rafael/0000-0003-2838-1514; Aiello-Lammens, Matthew/0000-0002-6180-5959; Chu, Ma Librada/0000-0003-3732-7165 FU Department of Defense [SI-1699]; University of Florida, High-Performance Computing Center FX Funding was provided by the Department of Defense Strategic Environmental Research and Development Program (project SI-1699). Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. The authors acknowledge the University of Florida, High-Performance Computing Center (http://hpc.ufl.edu) for providing computational resources and support that have contributed to the results reported in this paper. NR 61 TC 20 Z9 20 U1 0 U2 43 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD JAN 10 PY 2012 VL 224 IS 1 BP 33 EP 47 DI 10.1016/j.ecolmodel.2011.10.021 PG 15 WC Ecology SC Environmental Sciences & Ecology GA 869TW UT WOS:000298622100005 ER PT J AU Dissanayake, STM Onal, H Westervelt, JD Balbach, HE AF Dissanayake, Sahan T. M. Oenal, Hayri Westervelt, James D. Balbach, Harold E. TI Incorporating species relocation in reserve design models: An example from Ft. Benning GA SO ECOLOGICAL MODELLING LA English DT Article DE Reserve design; Climate change; Relocation; Protected land; Conservation; Military land use ID OPTIMAL TRANSLOCATION STRATEGIES; NATURAL-AREA PROTECTION; GLOBAL CLIMATE-CHANGE; MINIMAL FRAGMENTATION; CONSERVATION RESERVES; PROGRAMMING APPROACH; SELECTION; CONNECTIVITY; ALGORITHMS; NETWORKS AB Given the increasing expansion of human dominated landscapes it often becomes necessary to relocate endangered and at-risk species from existing habitat areas. Further, there is growing research stating that climatic and atmospheric changes attributed to climate change are already affecting species distributions and geographic ranges, requiring endangered species to be relocated. Existing reserve design models mostly focus on choosing the optimal land area given existing species distributions and have not incorporated species relocation as a criterion. This paper introduces linear integer programming formulations for the relocation of multiple populations of a species at risk to clustered conservation areas. We present a basic clustered relocation model and extend the model to minimize the distances of relocation. We apply the models to a dataset related to Gopher Tortoise (GT), a keystone species currently considered 'at risk', at Ft. Benning Georgia where expanding military training needs require the relocation of GTs. We present the results and discuss the trade-off between compactness and relocation considerations using an efficiency frontier. (C) 2011 Published by Elsevier B.V. C1 [Dissanayake, Sahan T. M.; Oenal, Hayri] Univ Illinois, Dept Agr & Consumer Econ, Urbana, IL 61801 USA. [Westervelt, James D.; Balbach, Harold E.] USA, ERDC CERL, Dr Champaign, IL 61822 USA. RP Dissanayake, STM (reprint author), Univ Illinois, Dept Agr & Consumer Econ, 405 Mumford Hall,MC-710,1301 W Gregory Dr, Urbana, IL 61801 USA. EM sdissan2@illinois.edu OI Dissanayake, Sahan/0000-0002-4342-5979 FU U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL) [W81EWF-7204-6330]; Cooperative State Research, Education, and Extension Service (CREES) [ILLU 05-0361] FX The authors express their gratitude to the participants in the AERE session (15H) at the Annual Meeting of the Southern Economics Association in 2008 and to the participants of the pERE workshop at University of Illinois for valuable comments and suggestions on an earlier draft of this manuscript. This research was partially supported by the U.S. Army Engineer Research and Development Center-Construction Engineering Research Laboratory (ERDC-CERL) project no. W81EWF-7204-6330 and Cooperative State Research, Education, and Extension Service (CREES) project no. ILLU 05-0361. NR 59 TC 6 Z9 6 U1 2 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD JAN 10 PY 2012 VL 224 IS 1 BP 65 EP 75 DI 10.1016/j.ecolmodel.2011.07.016 PG 11 WC Ecology SC Environmental Sciences & Ecology GA 869TW UT WOS:000298622100008 ER PT J AU Kumpfer, JR Wie, JJ Swanson, JP Beyer, FL Mackay, ME Rowan, SJ AF Kumpfer, Justin R. Wie, Jeong J. Swanson, John P. Beyer, Frederick L. Mackay, Michael E. Rowan, Stuart J. TI Influence of Metal Ion and Polymer Core on the Melt Rheology of Metallosupramolecular Films SO MACROMOLECULES LA English DT Article ID BONDED SUPRAMOLECULAR POLYMERS; MAIN-CHAIN; HYDROGEN-BONDS; SIDE-CHAIN; COORDINATION; NETWORKS; COPOLYMERS; MORPHOLOGY; DYNAMICS; BEHAVIOR AB Detailed rheological studies of metallosupramolecular polymer films in the melt were performed to elucidate the influence of the metal ion and polymer components on their mechanical and structural properties. 4-Oxy-2,6-bis(N-methylbenzimidazolyl)pyridine telechelic end-capped polymers with a low-T-g core, either poly(tetrahydrofuran) or poly(ethylene-co-butylene), were prepared with differing ratios of Zn2+ and Eu3+ to determine the influence of polymer chain chemistry and metal ion on the properties. Increasing the amount of the weaker binding europium yielded more thermoresponsive films in both systems, and results show that the nature of the polymer core dramatically affected the films mechanical properties. All of the films studied exhibited large relaxation times, and we use this to explain the pure sinusoidal behavior found in the "nonlinear" viscoelastic region. Basically, the system cannot relax during a strain cycle, allowing us to assume the network destruction and creation rates to be only a function of the strain amplitude in a simplified network model used to rationalize the observed behavior. C1 [Wie, Jeong J.; Mackay, Michael E.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA. [Kumpfer, Justin R.; Rowan, Stuart J.] Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA. [Mackay, Michael E.] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA. [Swanson, John P.] Calif Polytech State Univ San Luis Obispo, Dept Chem & Biochem, San Luis Obispo, CA 93407 USA. [Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mackay, ME (reprint author), Univ Delaware, Dept Chem Engn, 150 Acad St, Newark, DE 19716 USA. EM mem@udel.edu; stuart.rowan@case.edu RI Wie, Jeong Jae/C-6159-2012; Swanson, John/H-3596-2016 OI Swanson, John/0000-0001-8820-7273 FU U.S. Army Research Office [W911NF-09-1-0288]; National Science Foundation [CHE-0704026, DMR-0602869, MRI-0821515]; Case School of Engineering FX This material is based upon work supported by the U.S. Army Research Office (W911NF-09-1-0288), the National Science Foundation under Grants CHE-0704026, DMR-0602869, and MRI-0821515 (for the purchase of the MALDI-TOF/TOF), and the Case School of Engineering. NR 48 TC 34 Z9 34 U1 4 U2 49 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JAN 10 PY 2012 VL 45 IS 1 BP 473 EP 480 DI 10.1021/ma201659d PG 8 WC Polymer Science SC Polymer Science GA 873TD UT WOS:000298905000051 ER PT J AU Jhon, YK Arifuzzaman, S Ozcam, AE Kiserow, DJ Genzer, J AF Jhon, Young K. Arifuzzaman, Shafi Oezcam, Ali E. Kiserow, Douglas J. Genzer, Jan TI Formation of Polyampholyte Brushes via Controlled Radical Polymerization and Their Assembly in Solution SO LANGMUIR LA English DT Article ID POLY(ACRYLIC ACID) BRUSHES; ATOM-TRANSFER POLYMERIZATION; SURFACE-TETHERED DIBLOCK; CHARGED BLOCK-COPOLYMERS; METHYL-METHACRYLATE; POLYELECTROLYTE BRUSHES; MULTIVARIANT ASSEMBLIES; WEAK POLYELECTROLYTES; DENSITY GRADIENTS; CONTROLLED GROWTH AB We describe the formation of polyampholytic block copolymer brushes and their assembly in solution. Specifically, we employ "surface-initiated" activators regenerated by electron transfer atom transfer radical polymerization (ARGET-ATRP) sequentially to form diblock copolymer grafts comprising blocks of poly[2-(dimethyiamino) ethyl methacrylate] (PDMAEMA) and poly(sodium methacrylate) (PNaMA) on flat impenetrable silica surfaces, i.e., SiO(x)/PNaMA-b-PDMAEMA and SiO(x)/PDMAEMA-b-PNaMA. Protonation of the PNaMA block results in formation of poly(methacrylic acid) (PMAA). We demonstrate that ARGET-ATRP of NaMA provides a convenient route to preparation of PMAA, which is an alternative method to the more traditional approach based on preparing PMAA by polymerizing tert-butyl methacrylate (tBMA) followed by cleavage of the tert-butyl group. We also discuss conformational changes of the individual polyelectrolyte blocks in solution as a function of solution pH by monitoring adsorption behavior of functionalized polystyrene spheres. C1 [Jhon, Young K.; Arifuzzaman, Shafi; Oezcam, Ali E.; Kiserow, Douglas J.; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Jhon, Young K.; Kiserow, Douglas J.] Army Res Off, Res Triangle Pk, NC 27709 USA. RP Genzer, J (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. EM Jan_Genzer@ncsu.edu FU National Science Foundation; Army Research Office; National Research Council at Army Research Office FX This work was funded in part by the National Science Foundation and the Army Research Office. Y.K.J. thanks the National Research Council Research Associateship Award Program at the Army Research Office. The authors thank Ms. Elizabeth Melvin and Prof. Orlin Velev for their assistance with fluorescence microscopy measurements. NR 74 TC 22 Z9 22 U1 4 U2 48 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JAN 10 PY 2012 VL 28 IS 1 BP 872 EP 882 DI 10.1021/la203697a PG 11 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 873TC UT WOS:000298904900110 PM 22112235 ER PT J AU Cochrane, CJ Lenahan, PM Lelis, AJ AF Cochrane, C. J. Lenahan, P. M. Lelis, A. J. TI Identification of a silicon vacancy as an important defect in 4H SiC metal oxide semiconducting field effect transistor using spin dependent recombination SO APPLIED PHYSICS LETTERS LA English DT Article ID TRAPPING DEFECTS; RESONANCE; PASSAGE AB A spin dependent recombination (SDR) spectrum observed in a wide range of SiC metal oxide semiconducting field effect transistors (MOSFETs) has previously been only tentatively linked to a silicon vacancy or vacancy related defect. By resolving hyperfine interactions in SDR detected spectra with C-13 nuclei, we provide an extremely strong argument identifying the SDR spectrum with a silicon vacancy. Since the silicon vacancy spectrum dominates the SDR response in a wide variety of SiC MOSFETs, silicon vacancies are quite important traps in this technology. (C) 2012 American Institute of Physics. [doi: 10.1063/1.3675857] C1 [Cochrane, C. J.; Lenahan, P. M.] Penn State Univ, University Pk, PA 16802 USA. [Lelis, A. J.] USA, Res Lab, Adelphi, MD 20783 USA. RP Cochrane, CJ (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM corey.cochrane@gmail.com NR 16 TC 23 Z9 23 U1 3 U2 32 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 9 PY 2012 VL 100 IS 2 AR 023509 DI 10.1063/1.3675857 PG 3 WC Physics, Applied SC Physics GA 876SA UT WOS:000299126800089 ER PT J AU Wang, C Chang, YC Yao, JM Luo, CR Yin, S Ruffin, P Brantley, C Edwards, E AF Wang, Chao Chang, Yun-Ching Yao, Jimmy Luo, Claire Yin, Stuart (Shizhuo) Ruffin, Paul Brantley, Christina Edwards, Eugene TI Surface enhanced Raman spectroscopy by interfered femtosecond laser created nanostructures SO APPLIED PHYSICS LETTERS LA English DT Article ID SCATTERING; LITHOGRAPHY; ABLATION; SOLIDS; ARRAYS; METALS AB A type of surface enhanced Raman spectroscopy (SERS) by interfered femtosecond laser created nanostructures on Cu metal is presented. It is found out that finer and more uniform nanostructures (with an average feature size 100 nm or smaller) can be created on Cu metal by interfered femtosecond illumination with a phase mask. Significantly enhanced Raman signal (with an enhancement factor around 863) can be realized by using the nanostructured Cu substrate created by the interfered femtosecond laser illumination. The experimentally measured enhancement factor agrees relatively well with the theoretical analyses. Since the nanostructures can be inscribed in real time and at remote locations by the femtosecond laser inscription, the proposed SERS can be particularly useful for the standoff detection of chemicals. (C) 2012 American Institute of Physics. [doi: 10.1063/1.3676040] C1 [Wang, Chao; Chang, Yun-Ching; Yao, Jimmy; Yin, Stuart (Shizhuo)] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu FU ONR FX Authors greatly acknowledge the partial financial support of this work by an ONR basic research program. The views and opinions of its authors do not necessarily state or reflect those of the U. S. Government or any agency thereof. Reference to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise does not necessarily constitute or imply its endorsement, recommendation, or favoring by the U. S. Government or any agency thereof. NR 21 TC 18 Z9 18 U1 1 U2 19 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 9 PY 2012 VL 100 IS 2 AR 023107 DI 10.1063/1.3676040 PG 4 WC Physics, Applied SC Physics GA 876SA UT WOS:000299126800063 ER PT J AU Mayo, M Gheorghiu, S Pfeifer, P AF Mayo, Michael Gheorghiu, Stefan Pfeifer, Peter TI Diffusional screening in treelike spaces: An exactly solvable diffusion-reaction model SO PHYSICAL REVIEW E LA English DT Article ID FRACTAL POROUS CATALYST; IRREGULAR SURFACES; PULMONARY ACINUS; TRANSPORT; ADSORPTION; DESIGN; MEDIA AB A renormalization approach is used to derive an analytic formula for the total current crossing the reactive surface of a Cayley tree of cylindrical tubes under a Helmholtz-type approximation to the full diffusion-reaction problem. We provide analytic conditions for the emergence of a plateau in the current-a region of maximum insensitivity of the current to variations in either the reaction rate (membrane permeability) or the diffusivity. The occurrence of such a plateau is associated with a partial screening regime wherein most of the active surface is screened to incoming diffusing particles. Large trees trade efficiency for fault tolerance, a valuable feature which may provide robustness to mammalian respiratory systems and tolerance to catalytic poisoning in chemical reactors. C1 [Mayo, Michael; Pfeifer, Peter] Univ Missouri, Dept Phys & Astron, Columbia, MO 65201 USA. [Gheorghiu, Stefan] Ctr Complex Studies, Bucharest 061942, Romania. RP Mayo, M (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM michael.l.mayo@usace.army.mil OI Mayo, Michael/0000-0001-9014-1859 NR 26 TC 3 Z9 3 U1 1 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD JAN 9 PY 2012 VL 85 IS 1 AR 011115 DI 10.1103/PhysRevE.85.011115 PN 1 PG 7 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 876QK UT WOS:000299122400002 PM 22400520 ER PT J AU Viswanathan, L Vigersky, RA AF Viswanathan, Lavanya Vigersky, Robert A. TI The Effect of Herbal Medications on Thyroid Hormone Economy and Estrogen-Sensitive Hepatic Proteins in a Patient With Prostate Cancer SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID PC-SPES; HYPOTHYROIDISM; MANAGEMENT; WOMEN C1 [Vigersky, Robert A.] Walter Reed Natl Mil Med Ctr, Serv Endocrinol, Bethesda, MD 20889 USA. [Viswanathan, Lavanya] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Vigersky, RA (reprint author), Walter Reed Natl Mil Med Ctr, Serv Endocrinol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM Robert.vigersky@us.army.mil NR 11 TC 0 Z9 0 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD JAN 9 PY 2012 VL 172 IS 1 BP 58 EP 60 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 874LM UT WOS:000298958900010 PM 22232148 ER PT J AU Chen, Y O'Connell, JJ Ko, CJ Mayer, RR Belard, A McDonough, JE AF Chen, Yu O'Connell, John J. Ko, Christine J. Mayer, Rulon R. Belard, Arnaud McDonough, James E. TI Fiducial markers in prostate for kV imaging: quantification of visibility and optimization of imaging conditions SO PHYSICS IN MEDICINE AND BIOLOGY LA English DT Article ID DOSIMETRIC IMPACT; RADIATION-THERAPY; PROTON THERAPY; CANCER; RADIOTHERAPY; TRACKING; ALGORITHM; SYSTEM; MOTION; IMRT AB The purpose of this work is to investigate possible smaller, less-dense fiducial markers implantable into the prostate for target localization and patient repositioning verification in an on-board kV-kV imaging system on a proton gantry. The experiments used a pelvic phantom and a variety of commercially available fiducial markers: CIVCO carbon marker of phi; 1 x 3 mm, gold seed markers of phi; 0.8 x 3 mm and phi; 1.2 x 3 mm, and IBA Visicoil helical gold linear markers in diameters of 0.35, 0.50, 0.75 and 1.15 mm. Two orthogonal on-board kV imagers were arranged for digital radiographic imaging of the phantom through the lateral and anterior-posterior directions. The contrast-to-noise ratio (CNR) for a given marker was calculated and used as a quantitative measure of its visibility. The patient entrance skin exposure (ESE) was measured and parameterized for kVp, mAs and source-to-surface distance. The ratio of CNR to ESE was first introduced to characterize the efficiency for imaging a marker using a given x-ray technique in order to optimize the marker's visibility and simultaneously minimize the x-ray imaging dose. If CNR > 2, which corresponds to a significance p < 0.05, is required for acceptable visibility, the carbon marker and the smallest Visicoil marker are not suitable for imaging through dense bone but the others are capable of being employed in the clinic. It is predicted that other markers in development should have a greater thickness than equivalent of 0.14 mm thick gold in order to produce the acceptable visibility in the lateral kV imaging. The linear Visicoil marker of phi; 0.50 x 5 mm is most suitable for kV imaging in the prostate for proton therapy as it induces the least proton dose perturbation amongst the acceptable markers. An optimal range of 120-130 kVp and 40-80 mAs is determined using the maximal CNR/ESE and CNR > 2 for laterally imaging this marker in the prostate. C1 [Chen, Yu; Mayer, Rulon R.; Belard, Arnaud] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20852 USA. [Chen, Yu; O'Connell, John J.; Ko, Christine J.; Mayer, Rulon R.; Belard, Arnaud] Walter Reed Army Med Ctr, Radiat Oncol Serv, Washington, DC 20307 USA. [McDonough, James E.] Univ Penn, Dept Radiat Oncol, Med Ctr, Philadelphia, PA 19104 USA. RP Chen, Y (reprint author), Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20852 USA. EM dr.yu.chen@gmail.com RI Chen, Yu/E-3788-2012 FU US Army Medical Research and Material Command [DAMD17-W81XWH-04-2-0022] FX The authors wish to thank the IBA Group and CIVCO Medical Solutions for providing the samples of the fiducial markers. The authors would also like to thank Gerry Vantellingen from IBA for providing manufacturing details of the Visicoil markers, Andrew Jones from Cortex for helpful discussions about the carbon and polymer markers, and Xinhua Li from the Massachusetts General Hospital for discussions on the parameterization of x-ray exposure. This work was supported by the US Army Medical Research and Material Command under Contract Agreement no DAMD17-W81XWH-04-2-0022. The views expressed in this paper are those of the author and do not reflect the official policy of the Department of the Army, Department of Defense, or US Government. NR 25 TC 3 Z9 3 U1 0 U2 6 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0031-9155 J9 PHYS MED BIOL JI Phys. Med. Biol. PD JAN 7 PY 2012 VL 57 IS 1 BP 155 EP 172 DI 10.1088/0031-9155/57/1/155 PG 18 WC Engineering, Biomedical; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Radiology, Nuclear Medicine & Medical Imaging GA 863FH UT WOS:000298147700011 PM 22127351 ER PT J AU Johnston, SC Lin, KL Connor, JH Ruthel, G Goff, A Hensley, LE AF Johnston, Sara C. Lin, Kenny L. Connor, John H. Ruthel, Gordon Goff, Arthur Hensley, Lisa E. TI In vitro inhibition of monkeypox virus production and spread by Interferon-beta SO VIROLOGY JOURNAL LA English DT Article DE Orthopoxvirus; Monkeypox virus; Type I interferon; IFN-beta; MxA ID DOUBLE-STRANDED-RNA; HUMAN MXA PROTEIN; VACCINIA VIRUS; SMALLPOX VACCINATION; HOST-RANGE; ANTIVIRAL ACTIVITY; IMMUNE-RESPONSES; RESISTANCE GENE; INFLUENZA-VIRUS; ALPHA-SUBUNIT AB Background: The Orthopoxvirus genus contains numerous virus species that are capable of causing disease in humans, including variola virus (the etiological agent of smallpox), monkeypox virus, cowpox virus, and vaccinia virus (the prototypical member of the genus). Monkeypox is a zoonotic disease that is endemic in the Democratic Republic of the Congo and is characterized by systemic lesion development and prominent lymphadenopathy. Like variola virus, monkeypox virus is a high priority pathogen for therapeutic development due to its potential to cause serious disease with significant health impacts after zoonotic, accidental, or deliberate introduction into a naive population. Results: The purpose of this study was to investigate the prophylactic and therapeutic potential of interferon-beta (IFN-beta) for use against monkeypox virus. We found that treatment with human IFN-beta results in a significant decrease in monkeypox virus production and spread in vitro. IFN-beta substantially inhibited monkeypox virus when introduced 6-8 h post infection, revealing its potential for use as a therapeutic. IFN-beta induced the expression of the antiviral protein MxA in infected cells, and constitutive expression of MxA was shown to inhibit monkeypox virus infection. Conclusions: Our results demonstrate the successful inhibition of monkeypox virus using human IFN-beta and suggest that IFN-beta could potentially serve as a novel safe therapeutic for human monkeypox disease. C1 [Johnston, Sara C.; Lin, Kenny L.; Goff, Arthur; Hensley, Lisa E.] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Ruthel, Gordon] USA, Div Toxicol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Connor, John H.] Boston Univ, Sch Med & Microbiol, Dept Microbiol, Boston, MA 02118 USA. RP Johnston, SC (reprint author), USA, Div Virol, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM sara.johnston@amedd.army.mil OI Connor, John/0000-0002-8867-7256 FU Defense Threat Reduction Agency [195726] FX This work was funded by the Defense Threat Reduction Agency Project # 195726. Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 69 TC 5 Z9 5 U1 1 U2 9 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD JAN 6 PY 2012 VL 9 AR 5 DI 10.1186/1743-422X-9-5 PG 15 WC Virology SC Virology GA 950LV UT WOS:000304651700002 PM 22225589 ER PT J AU Hsiang, MS Hwang, J Kunene, S Drakeley, C Kandula, D Novotny, J Parizo, J Jensen, T Tong, M Kemere, J Dlamini, S Moonen, B Angov, E Dutta, S Ockenhouse, C Dorsey, G Greenhouse, B AF Hsiang, Michelle S. Hwang, Jimee Kunene, Simon Drakeley, Chris Kandula, Deepika Novotny, Joseph Parizo, Justin Jensen, Trevor Tong, Marcus Kemere, Jordan Dlamini, Sabelo Moonen, Bruno Angov, Evelina Dutta, Sheetij Ockenhouse, Christian Dorsey, Grant Greenhouse, Bryan TI Surveillance for Malaria Elimination in Swaziland: A National Cross-Sectional Study Using Pooled PCR and Serology SO PLOS ONE LA English DT Article ID DRIED BLOOD SPOTS; TRANSMISSION; FEASIBILITY; PLASMODIUM; COMMUNITY; MARKERS AB Background: To guide malaria elimination efforts in Swaziland and other countries, accurate assessments of transmission are critical. Pooled-PCR has potential to efficiently improve sensitivity to detect infections; serology may clarify temporal and spatial trends in exposure. Methodology/Principal Findings: Using a stratified two-stage cluster, cross-sectional design, subjects were recruited from the malaria endemic region of Swaziland. Blood was collected for rapid diagnostic testing (RDT), pooled PCR, and ELISA detecting antibodies to Plasmodium falciparum surface antigens. Of 4330 participants tested, three were RDT-positive yet false positives by PCR. Pooled PCR led to the identification of one P. falciparum and one P. malariae infection among RDT-negative participants. The P. falciparum-infected participant reported recent travel to Mozambique. Compared to performing individual testing on thousands of samples, PCR pooling reduced labor and consumable costs by 95.5%. Seropositivity was associated with age >= 20 years (11.7% vs 1.9%, P < 0.001), recent travel to Mozambique (OR 4.4 [95% CI 1.0-19.0]) and residence in southeast Swaziland (RR 3.78, P < 0.001). Conclusions: The prevalence of malaria infection and recent exposure in Swaziland are extremely low, suggesting elimination is feasible. Future efforts should address imported malaria and target remaining foci of transmission. Pooled PCR and ELISA are valuable surveillance tools for guiding elimination efforts. C1 [Hsiang, Michelle S.; Hwang, Jimee; Kandula, Deepika; Novotny, Joseph] Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. [Hsiang, Michelle S.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA. [Hwang, Jimee] Ctr Dis Control & Prevent, Malaria Branch, Atlanta, GA USA. [Kunene, Simon; Dlamini, Sabelo] Dept Hlth, Malaria Control Program, Manzini, Swaziland. [Drakeley, Chris] London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1, England. [Kandula, Deepika; Novotny, Joseph; Moonen, Bruno] Clinton Hlth Access Initiat, Boston, MA USA. [Parizo, Justin; Jensen, Trevor] Univ Calif San Francisco, Sch Med, San Francisco, CA USA. [Tong, Marcus] Univ Calif Los Angeles, Sch Engn & Appl Sci, Los Angeles, CA 90024 USA. [Kemere, Jordan] Univ N Carolina, Chapel Hill, NC USA. [Angov, Evelina; Dutta, Sheetij; Ockenhouse, Christian] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Dorsey, Grant; Greenhouse, Bryan] Univ Calif San Francisco, Dept Med, San Francisco, CA USA. RP Hsiang, MS (reprint author), Univ Calif San Francisco, Global Hlth Grp, San Francisco, CA 94143 USA. EM HsiangM@peds.ucsf.edu OI Greenhouse, Bryan/0000-0003-0287-9111 FU Global Fund to Fight AIDS, Tuberculosis and Malaria; Southern Africa Roll Back Malaria Network through Swaziland Ministry of Health [A115545]; Pediatric Infectious Diseases Society [A112604]; Bill and Melinda Gates Foundation [A108197] FX Global Fund to Fight AIDS, Tuberculosis and Malaria and Southern Africa Roll Back Malaria Network through Swaziland Ministry of Health (grant A115545); Pediatric Infectious Diseases Society (grant A112604); and the Bill and Melinda Gates Foundation (grant A108197). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 37 Z9 37 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 6 PY 2012 VL 7 IS 1 AR e29550 DI 10.1371/journal.pone.0029550 PG 8 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 904IR UT WOS:000301188800020 PM 22238621 ER PT J AU Mukherjee, J Tremblay, JM Leysath, CE Ofori, K Baldwin, K Feng, XC Bedenice, D Webb, RP Wright, PM Smith, LA Tzipori, S Shoemaker, CB AF Mukherjee, Jean Tremblay, Jacqueline M. Leysath, Clinton E. Ofori, Kwasi Baldwin, Karen Feng, Xiaochuan Bedenice, Daniela Webb, Robert P. Wright, Patrick M. Smith, Leonard A. Tzipori, Saul Shoemaker, Charles B. TI A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model SO PLOS ONE LA English DT Article ID HEAVY-CHAIN ANTIBODIES; G IMMUNE-COMPLEXES; MONOCLONAL-ANTIBODIES; BINDING-AGENTS; HIGH-AFFINITY; LIGHT-CHAIN; NEUROTOXIN; FRAGMENTS; DOMAIN; NEUTRALIZATION AB Antitoxins are needed that can be produced economically with improved safety and shelf life compared to conventional antisera-based therapeutics. Here we report a practical strategy for development of simple antitoxin therapeutics with substantial advantages over currently available treatments. The therapeutic strategy employs a single recombinant 'targeting agent' that binds a toxin at two unique sites and a 'clearing Ab' that binds two epitopes present on each targeting agent. Co-administration of the targeting agent and the clearing Ab results in decoration of the toxin with up to four Abs to promote accelerated clearance. The therapeutic strategy was applied to two Botulinum neurotoxin (BoNT) serotypes and protected mice from lethality in two different intoxication models with an efficacy equivalent to conventional antitoxin serum. Targeting agents were a single recombinant protein consisting of a heterodimer of two camelid anti-BoNT heavy-chain-only Ab VH (VHH) binding domains and two E-tag epitopes. The clearing mAb was an anti-E-tag mAb. By comparing the in vivo efficacy of treatments that employed neutralizing vs. non-neutralizing agents or the presence vs. absence of clearing Ab permitted unprecedented insight into the roles of toxin neutralization and clearance in antitoxin efficacy. Surprisingly, when a post-intoxication treatment model was used, a toxin-neutralizing heterodimer agent fully protected mice from intoxication even in the absence of clearing Ab. Thus a single, easy-to-produce recombinant protein was as efficacious as polyclonal antiserum in a clinically-relevant mouse model of botulism. This strategy should have widespread application in antitoxin development and other therapies in which neutralization and/or accelerated clearance of a serum biomolecule can offer therapeutic benefit. C1 [Mukherjee, Jean; Tremblay, Jacqueline M.; Ofori, Kwasi; Baldwin, Karen; Feng, Xiaochuan; Bedenice, Daniela; Tzipori, Saul; Shoemaker, Charles B.] Tufts Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA USA. [Leysath, Clinton E.] NIAID, NIH, Bethesda, MD 20892 USA. [Webb, Robert P.; Wright, Patrick M.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Mukherjee, J (reprint author), Tufts Cummings Sch Vet Med, Dept Biomed Sci, North Grafton, MA USA. EM charles.shoemaker@tufts.edu FU National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH); Department of Health and Human Services [N01-AI-30050, U54 AI057159]; NIAID, Bethesda, MD, USA FX This project was funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and the Department of Health and Human Services, under Contract No. N01-AI-30050 and Award Number U54 AI057159. Some work was also supported by the Intramural Research Program of the NIAID, Bethesda, MD, USA. The content is solely the responsibility of the authors and does not necessarily represent the official views of NIAID or NIH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 34 TC 33 Z9 33 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 6 PY 2012 VL 7 IS 1 AR e29941 DI 10.1371/journal.pone.0029941 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 904IR UT WOS:000301188800050 PM 22238680 ER PT J AU Valiyaveettil, M Alamneh, Y Oguntayo, S Wei, YL Wang, Y Arun, P Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas Oguntayo, Samuel Wei, Yanling Wang, Ying Arun, Peethambaran Nambiar, Madhusoodana P. TI Regional specific alterations in brain acetylcholinesterase activity after repeated blast exposures in mice SO NEUROSCIENCE LETTERS LA English DT Article DE Blast injury; Acetylcholinesterase; Cholinergic pathway; Traumatic brain injury; Repeated blast exposure ID REDUCED EVOKED RELEASE; CLOSED-HEAD INJURY; CHOLINERGIC DYSFUNCTION; COGNITIVE IMPAIRMENT; STRESS; RATS; MODEL; DEFICITS; BLOOD; OVERPRESSURE AB Acetylcholinesterase (AChE) which catalyzes the hydrolysis of the neurotransmitter acetylcholine has been recognized as one of the major regulators of stress responses after traumatic brain injury (TBI). Repeated blast exposure induces TBI (blast TBI) with a variable neuropathology at different brain regions. Since AChE inhibitors are being used as a line of treatment for TBI, we sought to determine the time course of AChE activity in the blood and different brain regions after repeated blast exposures using modified Ellman assay. Our data showed that repeated blast exposures significantly reduced AChE activity in the whole-blood and erythrocytes by 3-6 h, while plasma AChE activity was significantly increased by 3 h post-blast. In the brain, significant increase in AChE activity was observed at 6 h in the frontal cortex, while hind cortex and hippocampus showed a significant decrease at 6 h post-blast, which returned to normal levels by 7 days. AChE activity in the cerebellum and mid brain showed a decrease at 6 h, followed by significant increase at 3 days and that was decreased significantly at 14 days post-blast. Medulla region showed decreased AChE activity at 24 h post-blast, which was significantly increased at 14 days. These results suggest that there are brain regional and time-related changes in AChE activity after tightly coupled repeated blast exposures in mice. In summary, acute and chronic regional specific changes in the AChE activity after repeated blast exposures warrant systematic evaluation of the possibility of AChE inhibitor therapeutics against blast TBI. Published by Elsevier Ireland Ltd. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Oguntayo, Samuel; Wei, Yanling; Wang, Ying; Arun, Peethambaran; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. EM m.valiyaveettil@amedd.army.mil; madhusoodana.nambiar@amedd.army.mil NR 40 TC 8 Z9 8 U1 0 U2 6 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD JAN 6 PY 2012 VL 506 IS 1 BP 141 EP 145 DI 10.1016/j.neulet.2011.10.067 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 891GK UT WOS:000300205000029 PM 22079491 ER PT J AU Rangasamy, E Wolfenstine, J Sakamoto, J AF Rangasamy, Ezhiyl Wolfenstine, Jeff Sakamoto, Jeffrey TI The role of Al and Li concentration on the formation of cubic garnet solid electrolyte of nominal composition Li7La3Zr2O12 SO SOLID STATE IONICS LA English DT Article DE Phase formation; Garnet; Li; Al; Cubic; Ionic conductivity; Hot-pressing ID MIXED CONDUCTORS; CONDUCTIVITY; TRANSITION; BATTERY; MODEL AB The effect of Al and Li concentration on the formation of cubic garnet of nominal composition Li7La3Zr2O12 was investigated. It was determined that at least 0.204 moles of Al is required to stabilize the cubic phase. It was observed for the cubic phase (stabilized by the addition of Al) that as Li content was increased from 6 to 7 moles it transformed to a tetragonal phase. Additionally, powders of cubic Li6.24La3Zr2Al0.24O11.98 were hot-pressed at 1000 degrees C and 40 MPa. The hot-pressed material had a relative density of 98%. The room temperature total ionic conductivity of the hot-pressed material was 4.0 x 10(-4) S/cm and the electronic conductivity was 2 x 10(-8) S/cm. (C) 2011 Elsevier B.V. All rights reserved. C1 [Rangasamy, Ezhiyl; Sakamoto, Jeffrey] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Wolfenstine, Jeff] RDRL SED C, Army Res Lab, Adelphi, MD 20783 USA. RP Sakamoto, J (reprint author), Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. EM jsakamot@egr.msu.edu RI Rangasamy, Ezhiylmurugan/K-8340-2013 FU U. S. Army Research Office (ARO); U. S. Army Research Laboratory (ARL) FX EL and JS authors would like to acknowledge the support of the U. S. Army Research Office (ARO). JW would like to acknowledge support of the U. S. Army Research Laboratory (ARL). NR 16 TC 151 Z9 153 U1 25 U2 151 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2738 J9 SOLID STATE IONICS JI Solid State Ion. PD JAN 5 PY 2012 VL 206 BP 28 EP 32 DI 10.1016/j.ssi.2011.10.022 PG 5 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA 901KM UT WOS:000300965800005 ER PT J AU Polashenski, C Perovich, D Courville, Z AF Polashenski, Chris Perovich, Donald Courville, Zoe TI The mechanisms of sea ice melt pond formation and evolution SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID MICROWAVE-SCATTERING; MASS-BALANCE; SUMMER; ALBEDO; PERMEABILITY; PERCOLATION; TRANSPORT AB A series of observations were made on melting first year, landfast Arctic sea ice near Barrow, Alaska to explore the seasonal evolution of melt pond coverage. Observations of pond coverage, albedo, and ice properties are combined with terrestrial lidar measurements of surface topography and meltwater balance to quantitatively identify the timing and role of mechanisms driving pond coverage. The formation of interposed fresh ice is found to eliminate meltwater percolation through early pond formation and allow widespread ponding well above sea level. Pond drainage to sea level occurs principally by horizontal meltwater transport over the ice surface to macroscopic flaws. Freeboard loss, caused by buoyancy decline as the ice thins, controls pond growth late in the melt season after percolation begins. The majority of the macroscopic flaws that drain melt ponds to sea level are observed to develop from brine drainage channels within the ice. A simple thermodynamic model of meltwater percolation illustrates that fresh meltwater inflow causes pores in the ice to either shrink and freeze shut or enlarge based on initial size and ice temperature. This threshold behavior of pore diameter controls both the blockage of smaller pores with interposed ice and the enlargement of larger brine drainage channels to allow meltwater drainage. The results identify links between the temporal evolution of pond coverage and ice temperature, salinity, and thickness, providing new opportunities to realistically parameterize ponds and summer ice albedo within sea ice models. C1 [Polashenski, Chris] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Perovich, Donald; Courville, Zoe] CRREL, Terr & Cryospher Sci Branch, Hanover, NH 03755 USA. RP Polashenski, C (reprint author), Dartmouth Coll, Thayer Sch Engn, HB 8000, Hanover, NH 03755 USA. EM chris.polashenski@gmail.com FU National Science Foundation [ARC-0454900]; Dartmouth College FX The authors acknowledge Steve Ackley and two anonymous reviewers, each of whom contributed substantially to the improvement of this paper. We also gratefully acknowledge the loan and support of a TLS from Dave Finnegan, substantial field work contributions by Kerry Claffey, and able technical assistance of Bruce Elder. Ice core and surface elevation data used to validate and improve several findings was collected and generously made available on the Barrow Ice Observatory website by Chris Petrich, Hajo Eicken, and Matthew Druckenmiller, who also all collaborated most helpfully in the field. Logistical support was provided by the Barrow Arctic Science Consortium, particularly Gilford Mongyak, Nok Acher, Michael Donovan, and Lewis Brower. This research was funded by the National Science Foundation through grant ARC-0454900 and fellowship support of the Dartmouth College Polar Environmental Change IGERT Program. NR 51 TC 61 Z9 63 U1 2 U2 25 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JAN 5 PY 2012 VL 117 AR C01001 DI 10.1029/2011JC007231 PG 23 WC Oceanography SC Oceanography GA 874CD UT WOS:000298931700002 ER PT J AU Gong, P Loh, PR Barker, ND Tucker, G Wang, N Zhang, CH Escalon, BL Berger, B Perkins, EJ AF Gong, Ping Loh, Po-Ru Barker, Natalie D. Tucker, George Wang, Nan Zhang, Chenhua Escalon, B. Lynn Berger, Bonnie Perkins, Edward J. TI Building Quantitative Prediction Models for Tissue Residue of Two Explosives Compounds in Earthworms from Microarray Gene Expression Data SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID 2,4,6-TRINITROTOLUENE TNT; ENVIRONMENTAL TOXICOLOGY; TOXICITY AB Soil contamination near munitions plants and testing grounds is a serious environmental concern that can result in the formation of tissue chemical residue in exposed animals. Quantitative prediction of tissue residue still represents a challenging task despite long-term interest and pursuit, as tissue residue formation is the result of many dynamic processes including uptake, transformation, and assimilation. The availability of high-dimensional microarray gene expression data presents a new opportunity for computational predictive modeling of tissue residue from changes in expression profile. Here we analyzed a 240-sample data set with measurements of transcriptomic-wide gene expression and tissue residue of two chemicals, 2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitro-1,3,S-triazacyclohexane (RDX), in the earthworm Eisenia fetida. We applied two different computational approaches, LASSO (Least Absolute Shrinkage and Selection Operator) and RF (Random Forest), to identify predictor genes and built predictive models. Each approach was tested alone and in combination with a prior variable selection procedure that involved the Wilcoxon rank-sum test and HOPACH (Hierarchical Ordered Partitioning And Collapsing Hybrid). Model evaluation results suggest that LASSO was the best performer of minimum complexity on the TNT data set, whereas the combined Wilcoxon-HOPACH-RF approach achieved the highest prediction accuracy on the RDX data set. Our models separately identified two small sets of ca. 30 predictor genes for RDX and TNT. We have demonstrated that both LASSO and RF are powerful tools for quantitative prediction of tissue residue. They also leave more unknown than explained, however, allowing room for improvement with other computational methods and extension to mixture contamination scenarios. C1 [Gong, Ping; Barker, Natalie D.] Environm Serv SpecPro Inc, San Antonio, TX 78216 USA. [Loh, Po-Ru; Tucker, George; Berger, Bonnie] MIT, Dept Math & Comp Sci, Cambridge, MA 02139 USA. [Loh, Po-Ru; Tucker, George; Berger, Bonnie] MIT, Artificial Intelligence Lab, Cambridge, MA 02139 USA. [Wang, Nan] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Zhang, Chenhua] Univ So Mississippi, Dept Math, Hattiesburg, MS 39406 USA. [Escalon, B. Lynn; Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Gong, P (reprint author), Environm Serv SpecPro Inc, San Antonio, TX 78216 USA. EM ping.gong@usa.ce.army.mil; bab@mit.edu FU U.S. Army Environmental; Chief of Engineers FX We thank R. E. Boyd (Engineer Research & Development Center, Environmental Laboratory; ERDC-EL) for maintaining the earthworm culture, X. Guan and C. A. Hayes (ERDC-EL) for caring for the Perkin-Elmer Oxidizer, and Pedro Alvarez and Dong Li (Rice University, Department of Civil and Environmental Engineering) for making the R J. Harvey Oxidizer available to us when our Perkin-Elmer Oxidizer was down. We also thank the three anonymous reviewers for several suggestions that improved the quality of this manuscript. This work was funded by the U.S. Army Environmental Quality/Installation Applied Research Program as part of projects "Toxicogenomics for Assessment of Munitions and Explosives Related Compounds" and "Impact of Munitions Constituents on Biological Networks". Permission to publish this information was granted by the Chief of Engineers. NR 19 TC 6 Z9 6 U1 5 U2 22 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X EI 1520-5851 J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 3 PY 2012 VL 46 IS 1 BP 19 EP 26 DI 10.1021/es201187u PG 8 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 871UJ UT WOS:000298762900004 PM 21776976 ER PT J AU Garcia-Reyero, N Escalon, BL Loh, PR Laird, JG Kennedy, AJ Berger, B Perkins, EJ AF Garcia-Reyero, Natalia Escalon, B. Lynn Loh, Po-Ru Laird, Jennifer G. Kennedy, Alan J. Berger, Bonnie Perkins, Edward J. TI Assessment of Chemical Mixtures and Groundwater Effects on Daphnia magna Transcriptomics SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID LARGE GENE LISTS; MUNITIONS CONSTITUENTS; ALZHEIMERS-DISEASE; NORTHERN BOBWHITE; OXIDATIVE STRESS; TOXICITY; STRATEGY; ECOTOXICOLOGY; EXPLOSIVES; RESPONSES AB Small organisms can be used as biomonitoring tools to assess chemicals in the environment. Chemical stressors are especially hard to assess and monitor when present as complex mixtures. Here, fifteen polymerase chain reaction assays targeting Daphnia magna genes were calibrated to responses elicited in D. magna exposed for 24 h to five different doses each of the munitions constituents 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, 2,6-dinitrotoluene, trinitrobenzene, dinitrobenzene, or 1,3,5-trinitro-1,3,5-triazacyclohexane. A piecewise-linear model for log-fold expression changes in gene assays was used to predict response to munitions mixtures and contaminated groundwater under the assumption that chemical effects were additive. The correlations of model predictions with actual expression changes ranged from 0.12 to 0.78 with an average of 0.5. To better understand possible mixture effects, gene expression changes from all treatments were compared using high-density microarrays. Whereas mixtures and groundwater exposures had genes and gene functions in common with single chemical exposures, unique functions were also affected, which was consistent with the nonadditivity of chemical effects in these mixtures. These results suggest that, while gene behavior in response to chemical exposure can be partially predicted based on chemical exposure, estimation of the composition of mixtures from chemical responses is difficult without further understanding of gene behavior in mixtures. Future work will need to examine additive and nonadditive mixture effects using a much greater range of different chemical classes in order to clarify the behavior and predictability of complex mixtures. C1 [Escalon, B. Lynn; Laird, Jennifer G.; Kennedy, Alan J.; Perkins, Edward J.] USA, Corps Engineers, Environm Labs, Vicksburg, MS 39180 USA. [Garcia-Reyero, Natalia] Mississippi State Univ, Inst Genom Biocomp & Biotechnol, Starkville, MS USA. [Loh, Po-Ru; Berger, Bonnie] MIT, Dept Math, Cambridge, MA 02139 USA. RP Perkins, EJ (reprint author), USA, Corps Engineers, Environm Labs, Halls Ferry Rd, Vicksburg, MS 39180 USA. EM edward.j.perkins@usace.army.mil FU U.S. Army Environmental Quality Research Program [BAA 08-4379] FX This work was funded by the U.S. Army Environmental Quality Research Program (including BAA 08-4379). Permission for publishing this information has been granted by the Chief of Engineers. We thank Amber Russell for chemical analysis of the LAAP samples. NR 30 TC 13 Z9 13 U1 2 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 3 PY 2012 VL 46 IS 1 BP 42 EP 50 DI 10.1021/es201245b PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 871UJ UT WOS:000298762900007 PM 21744839 ER PT J AU Villeneuve, DL Garcia-Reyero, N Escalon, BL Jensen, KM Cavallin, JE Makynen, EA Durhan, EJ Kahl, MD Thomas, LM Perkins, EJ Ankley, GT AF Villeneuve, Daniel L. Garcia-Reyero, Natalia Escalon, B. Lynn Jensen, Kathleen M. Cavallin, Jenna E. Makynen, Elizabeth A. Durhan, Elizabeth J. Kahl, Michael D. Thomas, Linnea M. Perkins, Edward J. Ankley, Gerald T. TI Ecotoxicogenomics to Support Ecological Risk Assessment: A Case Study with Bisphenol A in Fish SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID TRANSCRIPTIONAL-EFFECT-LEVEL; MINNOW PIMEPHALES-PROMELAS; FATHEAD MINNOW; GENE-EXPRESSION; IN-VITRO; EXPOSURE; VITELLOGENIN; MICROARRAY; ZEBRAFISH; PROFILES AB Effects of bisphenol A (BPA) on ovarian transcript profiles as well as targeted end points with endocrine/reproductive relevance were examined in two fish species, fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), exposed in parallel using matched experimental designs. Four days of waterborne exposure to 10 mu g BPA/L caused significant vitellogenin induction in both species. However, zebrafish were less sensitive to effects on hepatic gene expression and steroid production than fathead minnow and the magnitude of vitellogenin induction was more modest (i.e., 3-fold compared to 13000-fold in fathead minnow). The concentration response at the ovarian transcriptome level was nonmonotonic and violated assumptions that underlie proposed methods for estimating hazard thresholds from transcriptomic results. However, the nonmonotonic profile was consistent among species and there were nominal similarities in the functions associated with the differentially expressed genes, suggesting potential activation of common pathway perturbation motifs in both species. Overall, the results provide an effective case study for considering the potential application of ecotoxicogenomics to ecological risk assessments and provide novel comparative data regarding effects of BPA in fish. C1 [Villeneuve, Daniel L.; Jensen, Kathleen M.; Cavallin, Jenna E.; Makynen, Elizabeth A.; Durhan, Elizabeth J.; Kahl, Michael D.; Thomas, Linnea M.; Ankley, Gerald T.] US EPA, Mid Continent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Escalon, B. Lynn; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Villeneuve, DL (reprint author), US EPA, Mid Continent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM Villeneuve.dan@epa.gov FU U.S. Army Environmental Quality and Installation Research program [BAA 08-4379]; Chief of Engineers FX This manuscript has been subjected to review by the U.S. Environmental Protection Agency, National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does the mention of trade names or commercial products constitute endorsement or recommendation for use. A portion of this work was supported by the U.S. Army Environmental Quality and Installation Research program (including BAA 08-4379). Permission to publish this information was granted by the Chief of Engineers. We thank Leah C. Wehmas, Matthew A. Weberg, Sara Seidl, and Lyle Burgoon for additional technical support and Stephen Edwards and Car lie La Lone for helpful comments on the manuscript. NR 28 TC 30 Z9 30 U1 5 U2 69 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JAN 3 PY 2012 VL 46 IS 1 BP 51 EP 59 DI 10.1021/es201150a PG 9 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 871UJ UT WOS:000298762900008 PM 21786754 ER PT J AU McLinden, RJ Paris, RM Polonis, VR Close, NC Su, ZH Shikuma, CM Margolis, DM Kim, JH AF McLinden, Robert J. Paris, Robert M. Polonis, Victoria R. Close, Nicole C. Su, Zhaohui Shikuma, Cecilia M. Margolis, David M. Kim, Jerome H. TI Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170) SO AIDS LA English DT Article DE CD4(+) T cells; HAART; HIV; neutralizing antibodies; viral load ID IMMUNODEFICIENCY-VIRUS TYPE-1; ACTIVE ANTIRETROVIRAL THERAPY; STRUCTURED TREATMENT INTERRUPTION; CELLULAR IMMUNE-RESPONSES; T-CELL; DEPENDENT ENHANCEMENT; DISEASE PROGRESSION; INFECTED PATIENTS; LONGITUDINAL DATA; IN-VIVO AB Objective: We investigated the impact of neutralizing antibodies (NAbs) on CD4 T-cell count and viral load in a cohort of HAART recipients who underwent extended structured treatment interruption. Design: Substudy of NAb in the AIDS Clinical Trials Group 5170 trial. Methods: Early plasma samples from 50 volunteers who discontinued HAART were evaluated in a peripheral blood mononuclear cell-based neutralization assay against a panel of four subtype B primary isolates. Results: We found that high-titer (90% inhibitory dose > 500) NAb against two or more isolates was associated with reduced viral load (P = 0.003 at 12-week posttreatment interruption). This effect faded with time, losing significance (P = 0.161) by study conclusion. Participants possessing the highest NAb levels against individual isolates appeared more likely to have lower viral loads with the association gaining significance against the R5-tropic primary isolate US1 (P = 0.005). There was no association between broader neutralization and CD4 T-cell slope over time. Conclusion: The data suggest that high-titer NAb responses at the time of treatment interruption are associated with reduced viral load over time, but not CD4(+) T-cell decline. (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins C1 [McLinden, Robert J.; Shikuma, Cecilia M.] Univ Hawaii Manoa, Honolulu, HI 96822 USA. [Paris, Robert M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Close, Nicole C.] EmpiriStat Inc, Airy, MD USA. [Su, Zhaohui] Harvard Univ, CBAR, Boston, MA 02115 USA. [Margolis, David M.] Univ N Carolina, Chapel Hill, NC USA. RP Kim, JH (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program MHRP, 1600 E Gude Dr, Rockville, MD 20850 USA. EM jkim@hivresearch.org OI Margolis, David/0000-0001-5714-0002 FU National Institutes of Health [RR03061-18]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; Department of Defense (DOD) [W81XWH-07-2-0067] FX This work was supported by the following sources: National Institutes of Health grant RR03061-18 to the University of Hawai'i under the Research Centers in Minority Institution Program (RCMI). In addition this work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the Department of Defense (DOD). NR 67 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD JAN 2 PY 2012 VL 26 IS 1 BP 1 EP 9 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 863BA UT WOS:000298136600001 PM 21971356 ER PT S AU Sano, T Yu, J Medintz, J Yen, CF Doherty, K AF Sano, Tomoko Yu, Jian Medintz, Jessica Yen, Chian-Fong Doherty, Kevin BE Suarez, CE TI THE EFFECT OF FRICTION STIR WELDING ON THE MICROSTRUCTURE AND TENSILE PROPERTIES OF AL 2139-T8 ALLOYS SO LIGHT METALS 2012 SE Light Metals LA English DT Proceedings Paper CT Symposium on Light Metals / TMS Annual Meeting and Exhibition CY MAR 11-15, 2012 CL Orlando, FL SP TMS, TMS Aluminum Comm DE Al 2139; Friction Stir Weld; Tensile Properties ID ALUMINUM AB The welding process introduces heat, plastic deformation, and chemical variation into the weld joints and alters the microstructure, strength, and ductility of the welded region. In this research, two plates of Al 2139-T8 alloys were welded together by friction stir welding (FSW). An evaluation of the crystallographic texture, grain size, and morphology of the grains in the FSW region, in comparison to those of the grains outside of the weld region, was made by scanning electron microscopy (SEM) and electron backscattered diffraction. In addition, the quasi-static tensile behavior of samples from the FSW region and those from outside of the FSW region was characterized by in-situ tensile experiments in the SEM with digital image correlation. It was found that the ultimate tensile strength was greater in the samples from outside FSW region and the elongation was greater for samples from the FSW region. The full results of the effect of the FSW on the Al 2139 microstructure and tensile behavior will be discussed in detail. C1 [Sano, Tomoko; Yu, Jian; Yen, Chian-Fong] US Army Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. [Medintz, Jessica] Univ Texas San Antonio, San Antonio, TX 78249 USA. [Doherty, Kevin] U S Army Res Lab, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA. RP Sano, T (reprint author), US Army Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. OI doherty, kevin/0000-0002-5806-5283 NR 8 TC 0 Z9 0 U1 0 U2 2 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND SN 0147-0809 BN 978-1-11829-139-9 J9 LIGHT MET PY 2012 BP 497 EP 501 PG 5 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BGX97 UT WOS:000324538600084 ER PT J AU Jaja, C Briesch, DM Laoudi, J Voss, CR AF Jaja, Claire Briesch, Douglas M. Laoudi, Jamal Voss, Clare R. BE Calzolari, N Choukri, K Declerck, T Dogan, MU Maegaard, B Mariani, J Odijk, J Piperidis, S TI Assessing Divergence Measures for Automated Document Routing in an Adaptive MT System SO LREC 2012 - EIGHTH INTERNATIONAL CONFERENCE ON LANGUAGE RESOURCES AND EVALUATION LA English DT Proceedings Paper CT 8th International Conference on Language Resources and Evaluation (LREC) CY MAY 21-27, 2012 CL Istanbul, TURKEY SP Nuance, CELI Language & Informat Technol, European Media Lab GmbH (EML), IMMI, META-Net, Quaero, K-dictionaries DE domain-specific machine translation; divergence measures; document classification AB Custom machine translation (MT) engines systematically outperform general-domain MT engines when translating within the relevant custom domain. This paper investigates the use of the Jensen-Shannon divergence measure for automatically routing new documents within a translation system with multiple MT engines to the appropriate custom MT engine in order to obtain the best translation. Three distinct domains are compared, and the impact of the language, size, and preprocessing of the documents on the Jensen-Shannon score is addressed. Six test datasets are then compared to the three known-domain corpora to predict which of the three custom MT engines they would be routed to at runtime given their Jensen-Shannon scores. The results are promising for incorporating this divergence measure into a translation workflow. C1 [Jaja, Claire; Briesch, Douglas M.; Laoudi, Jamal; Voss, Clare R.] Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU EUROPEAN LANGUAGE RESOURCES ASSOC-ELRA PI PARIS PA 55-57, RUE BRILLAT-SAVARIN, PARIS, 75013, FRANCE BN 978-2-9517408-7-7 PY 2012 BP 3963 EP 3970 PG 8 WC Linguistics; Language & Linguistics SC Linguistics GA BGR95 UT WOS:000323927704008 ER PT S AU Close, R Gader, P Zare, A Wilson, J Dranishnikov, D AF Close, Ryan Gader, Paul Zare, Alina Wilson, Joseph Dranishnikov, Dmitri BE Shen, SS Lewis, PE TI Endmember Extraction Using the Physics-Based Multi-Mixture Pixel Model SO IMAGING SPECTROMETRY XVII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Imaging Spectrometry XVII CY AUG 13-14, 2012 CL San Diego, CA SP SPIE DE Hyperspectral image analysis; physics-based mixture models; reflectance spectroscopy; nonlinear unmixing; microscopic mixture; macroscopic mixture; multi-mixture pixel ID BIDIRECTIONAL REFLECTANCE SPECTROSCOPY; PRINCIPAL-COMPONENTS-ANALYSIS; HYPERSPECTRAL IMAGERY; QUANTITATIVE-ANALYSIS; SPECTRA; SURFACES AB A method of incorporating the multi-mixture pixel model into hyperspectral endmember extraction is presented and discussed. A vast majority of hyperspectral endmember extraction methods rely on the linear mixture model to describe pixel spectra resulting from mixtures of endmembers. Methods exist to unmix hyperspectral pixels using nonlinear models, but rely on severely limiting assumptions or estimations of the nonlinearity. This paper will present a hyperspectral pixel endmember extraction method that utilizes the bidirectional reflectance distribution function to model microscopic mixtures. Using this model, along with the linear mixture model to incorporate macroscopic mixtures, this method is able to accurately unmix hyperspectral images composed of both macroscopic and microscopic mixtures. The mixtures are estimated directly from the hyperspectral data without the need for a priori knowledge of the mixture types. Results are presented using synthetic datasets, of multi-mixture pixels, to demonstrate the increased accuracy in unmixing using this new physics-based method over linear methods. In addition, results are presented using a well-known laboratory dataset. C1 [Close, Ryan] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Close, R (reprint author), US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. NR 89 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9232-6 J9 PROC SPIE PY 2012 VL 8515 AR UNSP 85150L DI 10.1117/12.930288 PG 14 WC Optics; Imaging Science & Photographic Technology; Spectroscopy SC Optics; Imaging Science & Photographic Technology; Spectroscopy GA BHV24 UT WOS:000326729000016 ER PT S AU Leonard, KR Howe, J Oxford, DE AF Leonard, Kevin R. Howe, Jonathan Oxford, David E. BE Lewis, C Burgess, D TI Simulation of atmospheric turbulence effects and mitigation algorithms on stand-off automatic facial recognition SO OPTICS AND PHOTONICS FOR COUNTERTERRORISM, CRIME FIGHTING, AND DEFENCE VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Optics and Photonics for Counterterrorism, Crime Fighting, and Defence VIII CY SEP 24-26, 2012 CL Edinburgh, SCOTLAND SP SPIE, SELEX GALILEO, THALES DE Stand-off force protection; turbulence simulation; mitigation; biometrics; facial recognition AB Stand-off base and force protection surveillance measures primarily rely on electro-optic and thermal imaging technology. Atmospheric turbulence causes blur, distortion and intensity fluctuations that can severely degrade the image quality of these systems. This work explores the effects of turbulence image degradation on the performance of automatic facial recognition software and also looks at the potential benefit of turbulence mitigation algorithms. The goal of this work is to understand the feasibility of long-range facial recognition in degraded imaging conditions. In order to create a large enough database to match against, simulated imagery of different ranges and turbulence conditions were created using a horizontal view turbulence simulator and a subset of the Facial Recognition Technology (FERET) database. The simulated turbulence degraded imagery was then processed with facial recognition software and the results are compared against those from the pristine image set. Finally, the performance of the facial recognition software with turbulence mitigated imagery is also presented. C1 [Leonard, Kevin R.] US Army, RDECOM CERDEC Night Vis Elect Sensors Directorate, RDER NVM HE, Ft Belvoir, VA 22060 USA. RP Leonard, KR (reprint author), US Army, RDECOM CERDEC Night Vis Elect Sensors Directorate, RDER NVM HE, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 11 TC 2 Z9 2 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9287-6 J9 PROC SPIE PY 2012 VL 8546 AR 85460O DI 10.1117/12.979480 PG 17 WC Optics; Physics, Applied SC Optics; Physics GA BHU67 UT WOS:000326694100021 ER PT J AU Doherty, K Squillacioti, R Cheeseman, B Placzankis, B Gallardy, D AF Doherty, Kevin Squillacioti, Richard Cheeseman, Bryan Placzankis, Brian Gallardy, Denver BE Weiland, H Rollett, AD Cassada, WA TI EXPANDING THE AVAILABILITY OF LIGHTWEIGHT ALUMINUM ALLOY ARMOR PLATE PROCURED FROM DETAILED MILITARY SPECIFICATIONS SO PROCEEDINGS OF THE 13TH INTERNATIONAL CONFERENCE ON ALUMINUM ALLOYS (ICAA13) LA English DT Proceedings Paper CT 13th International Conference on Aluminum Alloys (ICAA) CY JUN 03-07, 2012 CL Carnegie Mellon Univ, Pittsburgh, PA SP TMS HO Carnegie Mellon Univ DE armor plate specifications; aluminum alloys; procurement; standardization; weldability AB For many years, the range of aluminum alloys for armor plate applications obtainable in accordance with detailed military specifications was very limited. However, the development of improved aluminum alloys for aerospace and other applications has provided an opportunity to modernize the Army portfolio for ground vehicle armor applications. While the benefits of offering additional alloy choices to vehicle designers is obvious, the process of creating detailed military specifications for armor plate applications is not trivial. A significant amount of material and testing is required to develop the details required by an armor plate specification. Due to the vast number of material programs that require standardization and with a limited amount of manpower and funds as a result of Standardization Reform in 1995, one typically requires a need statement from a vehicle program office to justify and sponsor the work. This presentation will focus on recent aluminum alloy armor plate specifications that have added capability to vehicle designers' selection of armor materials that offer possible benefits such as lower cost, higher strength, better ballistic and corrosion resistance, improved weldability, etc. C1 [Doherty, Kevin; Squillacioti, Richard; Cheeseman, Bryan; Placzankis, Brian; Gallardy, Denver] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Doherty, K (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND BN 978-1-11845-804-4 PY 2012 BP 541 EP 546 PG 6 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BHI12 UT WOS:000325479800079 ER PT J AU Sano, T Yu, J Chen, R Yen, CF AF Sano, Tomoko Yu, Jian Chen, Richard Yen, Chian-Fong BE Weiland, H Rollett, AD Cassada, WA TI THE EFFECT OF THE VARIATION OF MICROSTRUCTURE IN THE FRICTION STIR WELDED ZONE ON THE STRAIN AND TENSILE PROPERTIES OF AL2139 SO PROCEEDINGS OF THE 13TH INTERNATIONAL CONFERENCE ON ALUMINUM ALLOYS (ICAA13) LA English DT Proceedings Paper CT 13th International Conference on Aluminum Alloys (ICAA) CY JUN 03-07, 2012 CL Carnegie Mellon Univ, Pittsburgh, PA SP TMS HO Carnegie Mellon Univ DE Al 2139; Friction Stir Weld; Tensile Properties ID ALUMINUM; FRACTURE AB The friction stir welding process creates three distinct zones; the weld nugget, themo-mechanically affected zone, and the heat affected zone. These zones have varying microstructure, texture, amounts of plastic deformation and dynamic recrystallization. The elevated local stresses and non-uniform strains under tension are attributed to the inhomogeneity in the weld. The ultimate tensile strength (UTS), yield stress, and elastic modulus were determined by tensile tests of samples in three orthogonal orientations from inside and outside the weld. The samples from inside the weld showed lower UTS and yield strength, but longer elongation than those from outside the weld. Digital image correlation was used to map the strain variations of the samples during the tensile tests. In addition, electron backscattered diffraction was used to determine the grain size and texture variation of the grains in the weld zones. The correlation of the microstructure variation on the tensile properties will be discussed. C1 [Sano, Tomoko; Yu, Jian; Chen, Richard; Yen, Chian-Fong] US Army Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Sano, T (reprint author), US Army Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND BN 978-1-11845-804-4 PY 2012 BP 653 EP 658 PG 6 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BHI12 UT WOS:000325479800095 ER PT J AU Champagne, VK Trexler, M Sohn, Y Kim, GE AF Champagne, Victor K. Trexler, Matthew Sohn, Yongho Kim, George E. BE Weiland, H Rollett, AD Cassada, WA TI Novel Cold Spray Nanostructured Aluminum SO PROCEEDINGS OF THE 13TH INTERNATIONAL CONFERENCE ON ALUMINUM ALLOYS (ICAA13) LA English DT Proceedings Paper CT 13th International Conference on Aluminum Alloys (ICAA) CY JUN 03-07, 2012 CL Carnegie Mellon Univ, Pittsburgh, PA SP TMS HO Carnegie Mellon Univ DE Aluminum 5083; Nano-grained; Cold spray ID POWDER PARTICLES; COATINGS; VELOCITY; IMPACT AB This paper discusses the introduction of a relatively new materials consolidation process, referred to as 'Cold Spray', which has been shown to meet the low-temperature, high velocity criteria for the production of dense, oxide-free metal-base nanostructured materials that may contribute to stronger near net-shape spray nanostructured components and as an enabling repair technology. When spraying nanostructured coatings, there are particular requirements in preserving the microstructure and functionality of the feedstock powder in the final bulk material. This is especially true when depositing temperature sensitive and readily oxidizing materials such as carbides, nitrides, and nanostructered metals. For these materials, the goal is to replace most, if not all, of the thermal energy (i.e., flame temperature) with kinetic energy (i.e., particle velocity) so as to retain the nanostructure without contributing to coating oxidation or porosity. Osmotic consolidation, pressure filtration, and tape casting have been used to produce consolidated nanostructured materials with limited thickness. The low temperature and high kinetic energy associated with the cold spray process allow for the retention of fine/nano grain structure, absence of phase change, capability for thick deposits, and promotion of compressive residual coating stress. These capabilities make the cold spray process an ideal approach to depositing nanostructured metal-base coatings, as well as nanostructured bulk materials. This paper will present data associated with the cold spray development and materials characterization of nanostructured 5083 aluminum. C1 [Champagne, Victor K.; Trexler, Matthew] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Champagne, VK (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 10 TC 0 Z9 0 U1 4 U2 7 PU JOHN WILEY & SONS PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER, W SUSSEX PO 19 8SQ, ENGLAND BN 978-1-11845-804-4 PY 2012 BP 993 EP 998 PG 6 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA BHI12 UT WOS:000325479800148 ER PT B AU Vasquez, KB Logsdon, KP Dorman, DB Chancey, VC AF Vasquez, Kimberly B. Logsdon, Katie P. Dorman, Daniel B. Chancey, Valeta Carol GP ASME TI COMBAT HELMET-HEADFORM COUPLING CHARACTERIZED FROM BLUNT IMPACT EVENTS SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2011, VOL 2 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn ID PERFORMANCE AB Observed head injury has historically been mechanically related to headform center of gravity (CG) acceleration. Helmets (motorcycle, sports, military, etc.) are evaluated based on the headform CG peak acceleration for blunt impacts. However, recent interest has shifted to collecting data from the helmet shell itself, as it is an optimal location for mounting sensors due to ease of access, sufficient surface area availability, and limited interference to the wearer. In order to accurately predict head injury from data collected on the helmet shell, the helmet and headform must be rigidly coupled. Headform-helmet fit typically is dependent on the pad fitting system and the person mounting the helmet to the headform because a standard states which headform to use. The objective of this study is to compare the Department of Transportation (DOT) headform (currently used in military blunt impact testing) to the more anthropomorphic International Standard Organization (ISO) half headform. Testing was completed on a monorail drop tower to analyze the effect of helmet/headform coupling on the blunt impact behavior of ACH helmets using FMVSS test methodology. Three headform configurations were used: the DOT headform (standard for military helmet blunt impact testing) with required surrogate chin, the ISO half headform (standard for ASTM helmet testing), and the ISO half headform with a surrogate chin. The two currently field-approved pad types were also used to determine best headform-helmet fit. Results from these series of tests will be presented, including headform peak acceleration and relative motion between the helmet and headform. C1 [Vasquez, Kimberly B.; Logsdon, Katie P.; Dorman, Daniel B.; Chancey, Valeta Carol] US Army, Aeromed Res Lab, Ft Rucker, AL USA. RP Vasquez, KB (reprint author), US Army, Aeromed Res Lab, Ft Rucker, AL USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5488-4 PY 2012 BP 41 EP 49 PG 9 WC Engineering, Biomedical; Engineering, Mechanical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BGX47 UT WOS:000324505000006 ER PT B AU Hull, F Gambill, J Hansche, A Agni, G Evangelista, J Powell, C Auerbach, M Dillon, J Arnas, O AF Hull, Frazier Gambill, Jett Hansche, Andrew Agni, Gian Evangelista, John Powell, Celia Auerbach, Margaret Dillon, Joel Arnas, Oezer GP ASME TI ENGINEERING AN UNDERGARMENT FOR FLASH/FLAME PROTECTION SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2011, VOL 2 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn AB This paper presents a continuation of projects spanning the last two years. In year one, the physical characteristics and medical effects of burns and Improvised Explosive Device, TED, blasts were investigated [1]. In year two, the possible use of commercial intumescent materials with fabric was studied [2]. The identified needs for research into the effect of undergarments on burn protection are focused in this study. Additionally, Thermal Protective Performance, TPP-(ISO 17492) and Air Permeability, AP-(ASTM D737) tests were performed to gather the data needed for the analysis of flame and thermal resistance as well as comfort and breathability. Out of the seven samples evaluated, the Sample D, composed of 94% m-aramid, 5 p-aramid and 1% static dissipative fiber, shirt had the best overall performance in terms of air permeability, average TPP rating, and time to second degree burn. Another finding was that polyester undershirts may be dangerous in the event of a flash fire situation because the fabric could melt and stick to the Soldier's skin causing more severe bum injury. Additionally, an initial framework for a basic mathematical model representing the system was created. This model can be further refined to yield more accurate results and eventually be used to help predict the material properties required in fabrics to design a more protective undergarment. C1 [Hull, Frazier; Gambill, Jett; Hansche, Andrew; Agni, Gian; Evangelista, John; Arnas, Oezer] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Hull, F (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 7 TC 0 Z9 0 U1 0 U2 5 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5488-4 PY 2012 BP 297 EP 305 PG 9 WC Engineering, Biomedical; Engineering, Mechanical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BGX47 UT WOS:000324505000042 ER PT B AU Erbacher, RF Hutchinson, SE AF Erbacher, Robert F. Hutchinson, Steve E. GP IEEE TI Extending Case-Based Reasoning to Network Alert Reporting SO 2012 ASE INTERNATIONAL CONFERENCE ON CYBER SECURITY (CYBERSECURITY) LA English DT Proceedings Paper CT ASE International Conference on Cyber Security (CyberSecurity) / ASE International Conference on Social Informatics (SocialInformatics) / ASE International Conference on Biomedical Computing (BioMedCom) CY DEC 14-16, 2012 CL Washington, DC SP Acad Sci & Engn, IEEE Comp Soc DE Case-Based Reasoning; Incident Reporting; CyberSecurity ID SYSTEM; MEMORY AB A substantial amount of cyber security analyst time is spent handling well-known and naive threats and policy violations on the local network. This includes both the time spent actually identifying and analyzing the activity as well as generating and filing reports associated with the activity. With increasing concern over advanced persistent threats, there is an interest in the development of techniques to automatically handle well-known threats and policy violations. We propose extensions to existing case-based reasoning approaches to support the unique requirements of cybersecurity report generation. Specifically, we consider the fact that we are reporting on hostile actors that will attempt to game the system or manipulate the system to actually aid the actors in obfuscating their activity. In this paper, we describe the need for automated reporting, the applicability of case-based reasoning, our proposed extension to the standard case-based reasoning system model, and provide examples of the modified case-based reasoning system as applied to example cybersecurity scenarios. C1 [Erbacher, Robert F.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Hutchinson, Steve E.] US Army Res Lab, ICF Int Inc, Adelphi, MD 20783 USA. RP Erbacher, RF (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Robert.F.Erbacher.civ@mail.mil; Steve.E.Hutchinson.ctr@mail.mil NR 22 TC 2 Z9 2 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5014-5; 978-1-4799-0219-4 PY 2012 BP 187 EP 194 DI 10.1109/CyberSecurity.2012.31 PG 8 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BHP62 UT WOS:000326265700025 ER PT S AU Winterhalter, C Truong, Q Endrusick, T Cardello, A Lesher, L AF Winterhalter, Carole Quoc Truong Endrusick, Thomas Cardello, Armand Lesher, Larry BE Shepherd, AM TI Effects of Overgarment Moisture Vapor Transmission Rate on Human Thermal Comfort SO PERFORMANCE OF PROTECTIVE CLOTHING AND EQUIPMENT: EMERGING ISSUES AND TECHNOLOGIES, 9TH VOL SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT 9th Symposium on Protective Clothing and Equipment - Emerging Issues and Technologies CY JUN 16-17, 2011 CL Anaheim, CA SP ASTM Int Comm F23 Personal Protect Clothing & Equipment DE moisture vapor transmission rate; thermoregulatory responses; sensory comfort; semi-permeable membrane; protective clothing ID PHYSIOLOGICAL RESPONSES; AMBIENT TEMPERATURES; SENSORY COMFORT; SENSATIONS AB The purpose of this study is to evaluate the effects of moisture vapor transport properties of four different groups of overgarments (OGs) on physiological, sensory, and comfort responses. These OGs were made from materials containing an impermeable film and three semi-permeable (or moisture vapor permeable) membranes with varying moisture vapor transmission rates (MVTR). The impermeable film had an MVTR of 5 g/m(2)/24 h, and the three moisture vapor membranes had MVTRs of 360, 670, and 864. These four OGs were evaluated under two environmental and work/rest conditions. The environmental conditions consisted of a warm environment, Ta 29.2 degrees C, 51% relative humidity, V 1.1 m/s and a cool environment, Ta 18.4 degrees C, 50% relative humidity, V 1.1 m/s. Eight men wore the OGs while performing 4 h of intermittent exercise. Rectal temperature, an 8-point mean weighted skin temperature and heart rate were continuously recorded. Skin wettedness was calculated from dew point sensors under the OG. Mean body weight loss and moisture absorption by the OG, underwear, and footwear were measured from pre- and post-experiment weights. A sensory and comfort rating questionnaire was presented to the volunteers every 30 min. During prolonged intermittent exercise in moderate environmental conditions, volunteers wearing OGs with MVTR of 670 and greater produced less thermo-physiological stress, independent of changes in perceived comfort. Perceived comfort of the MVTR 5 OG was significantly lower than all other garments at 18.4 degrees C. At 29.2 degrees C, both the MVTR 5 and 360 OG produced lower comfort, but not significantly. At 29.2 degrees C, volunteers were significantly warmer, sweatier, and experienced significantly greater moisture on their skin, undergarments, and inside their OGs than at 18.4 degrees C, and these sensations increased over time. However, at 29.2 degrees C, perceived comfort differences among MVTR levels were either not significant or not associated with MVTR level. C1 [Winterhalter, Carole; Quoc Truong; Cardello, Armand; Lesher, Larry] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Winterhalter, C (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Kansas St, Natick, MA 01760 USA. NR 21 TC 0 Z9 0 U1 1 U2 5 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7530-3 J9 AM SOC TEST MATER PY 2012 VL 1544 BP 129 EP 157 DI 10.1520/STP104085 PG 29 WC Materials Science, Characterization & Testing; Materials Science, Textiles SC Materials Science GA BHL05 UT WOS:000325759300007 ER PT B AU Davis, TJ Helm, AM Sullivan, MD Tamm, G Hodges, CD AF Davis, Timothy J. Helm, Aaron M. Sullivan, Michael D. Tamm, Gunnar Hodges, Chris D. GP ASME TI ENHANCEMENT OF ELECTRONICS COOLING IN THE OH-58D KIOWA WARRIOR SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2011, VOL 1 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn AB The Bell OH-58 Kiowa helicopter was first introduced in 1969 and has undergone several retrofits to the present OH-58D Kiowa Warrior (KW) model. The KW has become heavily loaded with electronics for communications, weapons and sensors to enhance its overmatch capability against the enemy. However, the ability to cool the heating load of these systems is being stretched thin, especially in current hot operational environments. As a result, electrical component failure has resulted in reduced operational availability and extended maintenance periods. This paper presents a theoretical study performed by cadets and faculty at the U.S. Military Academy, in support of a request by Army PEO Aviation to explore alternatives. The thermal and flow characteristics of the current KW electronics bays are analyzed to identify weaknesses and potentials for quick retrofits. Several novel solutions are proposed and assessed, including redirection and enhancement of the flow, as well as cooling of the intake air or direct cooling of the electronics through mechanical, thermoelectric, evaporative and heat pipe methods. C1 [Davis, Timothy J.; Helm, Aaron M.; Sullivan, Michael D.; Tamm, Gunnar] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Davis, TJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM gunnar.tamm@usma.edu NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5487-7 PY 2012 BP 309 EP 315 PG 7 WC Engineering, Aerospace; Energy & Fuels; Engineering, Mechanical SC Engineering; Energy & Fuels GA BHD13 UT WOS:000325040500030 ER PT S AU Ervin, MH Mailly, B Palacios, T AF Ervin, M. H. Mailly, B. Palacios, T. BE Long, JW Brousse, T Simon, P Belanger, D Sugimoto, W Brodd, R TI Electrochemical Double Layer Capacitance of Metallic and Semiconducting SWCNTs and Single-Layer Graphene SO ELECTROCHEMICAL CAPACITORS: FUNDAME NTALS TO APPLICATIONS SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Electrochemical Capacitors - Fundamentals to Applications held during the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc, Battery, Energy Technol AB The specific double layer capacitance that has been achieved with single wall carbon nanotubes (SWCNTs) is below that which is predicted from calculations based on the theoretical surface area of the CNTs and the intrinsic capacitance of the electrolyte. This paper investigates the specific capacitance of metallic (M-) and semiconducting (SC-) CNTs in order to determine if density of states (DOS)/quantum capacitance is a limiting factor in the capacitances achieved. In addition, a model system composed of a large-area single-layer graphene electrode on a nonconducting substrate has been used in order to put a lower bound on the ultimate double layer capacitance that should be achievable with CNT and graphene electrodes. We find that at the specific capacitances achieved here, the quantum capacitance of SWCNTs is not the limiting factor. In addition, the single-sided single-layer graphene electrode indicates that capacitances in excess of 550 F/g should be achievable. C1 [Ervin, M. H.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ervin, MH (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 8 TC 1 Z9 1 U1 1 U2 11 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-321-6; 978-1-56677-962-3 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 22 BP 153 EP 160 DI 10.1149/1.3693070 PG 8 WC Electrochemistry SC Electrochemistry GA BHF06 UT WOS:000325212400012 ER PT B AU Yoo, JH Murugan, M Le, D AF Yoo, JinHyeong Murugan, Muthuvel Le, Dy GP ASME TI DEVELOPMENT OF A LUMPED-PARAMETER OCCUPANT INJURY ASSESSMENT MODEL FOR VEHICULAR BLAST EFFECTS SIMULATION SO PROCEEDINGS OF THE ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS, VOL 2 LA English DT Proceedings Paper CT ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems CY SEP 19-21, 2012 CL Stone Mountain, GA SP ASME, Gen Motors, Parker Hannifin, Dynalloy Inc, Teledyne Sci & Imag, IOP Publish, Sage Publish, NextGen Aeronaut, Natl Sci Fdn, Air Force Off Sci Res AB In this study, a lumped-parameter human body including lower leg in seated posture with a quarter-car model was developed for blast injury assessment simulation. To simulate the shock acceleration of the vehicle, mine blast analysis was conducted on a generic land vehicle crew compartment (sand box) structure. For the purpose of simulating human body dynamics, a physical model of lumped-parameter human body with a quarter car model was developed and implemented in multi-body dynamic simulation software. The injury criteria and tolerance levels for the biomechanical effects are discussed for each of the identified vulnerable body regions, such as the lower leg, the spine, and the neck. Passive seat and footrest damper devices were analytically evaluated to investigate their effectiveness for a seated occupant in a vehicle environment during a blast event. The seat damper has significant influence on the neck and the spine injury assessment values; however has less influence on the lower leg injury assessment value. For protecting the lower leg from injury, a separated footrest with a passive spring-damper system was more effective than the seat damper. C1 [Yoo, JinHyeong; Murugan, Muthuvel; Le, Dy] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Yoo, JH (reprint author), US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 11 TC 0 Z9 0 U1 1 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4510-3 PY 2012 BP 305 EP 312 PG 8 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Materials Science, Biomaterials SC Engineering; Materials Science GA BGX46 UT WOS:000324504300039 ER PT B AU Crawford, BG Byers, LK Fenley, QJ AF Crawford, B. Grant Byers, Lynn K. Fenley, Quinton J. GP ASME TI MODELING OF A SUPERSONIC EJECTION, PILOT PROTECTION SYSTEM SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2011, VOL 9 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn AB Supersonic Ejection has always been dangerous for pilots to attempt due to the extreme aerodynamic forces acting on the body. Previous solutions to this problem have been too heavy and/or too dangerous for fighter aircraft applications. In response to a request by Boeing Defense, Space and Security, this paper proposes a system that uses the aircraft's canopy as a ballistic shield to protect the pilot from the windblast in the initial stages of a supersonic ejection at Mach 1.4 and an altitude of 30,000 feet. Results show that the thrust needed for an ejection of this type is approximately 3,372 lbf for .75 seconds. The heaviest pilot will move 53 meters away from the aircraft, while the lightest pilot will only experience acceleration 6.6 times the acceleration due to gravity in the vertical direction. In the longitudinal direction (direction of flight), the lightest pilot will experience a deceleration of 26.2 times the acceleration due to gravity for an ejection at mach 1.4 and an altitude of 30,000 ft. While the maximum value for jerk found in this model falls within safe limits for the pilot, the simulation does not accurately model transient phenomena. This paper concludes that further research, modeling, and testing could produce a viable option for safe ejection from fighter aircraft at supersonic speeds primarily using existing components. C1 [Crawford, B. Grant; Byers, Lynn K.; Fenley, Quinton J.] US Mil Acad, West Point, NY 10996 USA. RP Crawford, BG (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5495-2 PY 2012 BP 665 EP 672 PG 8 WC Engineering, Mechanical; Transportation Science & Technology SC Engineering; Transportation GA BGZ58 UT WOS:000324716700071 ER PT S AU Swedberg, AD Hubbard, M AF Swedberg, Andrew D. Hubbard, Mont BE Johnson, RJ Shealy, JE Greenwald, RM Scher, IS TI Modeling Terrain Park Jumps: Linear Tabletop Geometry May Not Limit Equivalent Fall Height SO SKIING TRAUMA AND SAFETY, VOL 19 SE American Society for Testing and Materials Special Technical Publications LA English DT Proceedings Paper CT 19th Congress of the International-Society-for-Skiing-Safety (ISSS) CY MAY 01-07, 2011 CL Keystone, CO SP Int Soc Skiing Safety DE terrain park; tabletop jump; skiing; snowboarding; landing impact ID SPINAL-CORD INJURIES; HEAD AB Terrain park tabletop jumps have a shape that is common at many ski areas today. A safe, low-impact landing on any jump with a constant linear landing area requires that the component of jumper velocity perpendicular to the landing surface be small, and when velocities are large, achieving this requires that the jumper flight path angle be nearly equal to the landing surface angle. Landing impact severity can alternatively be measured using the equivalent fall height (EFH). Based on Newton's laws and assumed ballistic flight, this research presents a general expression for the EFH experienced by a jumper when landing at any possible point on any landing surface whatsoever. This general expression is then particularized to show the effects on the EFH of the four physical features of a generic tabletop jump with a flat, horizontal deck and a constant linear landing region: the takeoff angle theta(o), the coordinates of the knuckle x(t) and y(t) where the intended constant-slope landing region begins, and the snow landing surface angle phi in this region. Numerical results show that tabletop jump EFHs have increasing and possibly large values near the ends of both the tabletop and the linear landing downslope portions. We conclude that tabletop jumps do not exhibit a low impulse on landing everywhere, which increases the likelihood of jumper injuries relative to those jumps for which the EFH is small everywhere. C1 [Swedberg, Andrew D.] US Mil Acad, Dept Math Sci, MAJ, West Point, NY 10996 USA. RP Swedberg, AD (reprint author), US Mil Acad, Dept Math Sci, MAJ, West Point, NY 10996 USA. EM andrew.swedberg@usma.edu; mhubbard@ucdavis.edu NR 17 TC 0 Z9 0 U1 0 U2 2 PU ASTM INTERNATIONAL PI WEST CONSHOHOCKEN PA 100 BARR HARBOR DRIVE, PO BOX C700, WEST CONSHOHOCKEN, PA 19428-2959 USA SN 0066-0558 BN 978-0-8031-7539-6 J9 AM SOC TEST MATER PY 2012 VL 1558 BP 120 EP 135 DI 10.1520/STP104335 PG 16 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA BHE99 UT WOS:000325210800008 ER PT J AU Callahan, D Shakarian, P Nielsen, J Johnson, AN AF Callahan, Devon Shakarian, Paulo Nielsen, Jeffrey Johnson, Anthony N. GP IEEE TI Shaping Operations to Attack Robust Terror Networks SO PROCEEDINGS OF THE 2012 ASE INTERNATIONAL CONFERENCE ON SOCIAL INFORMATICS (SOCIALINFORMATICS 2012) LA English DT Proceedings Paper CT ASE International Conference on Social Informatics (SocialInformatics) CY DEC 14-16, 2012 CL Washington, DC SP Acad Sci & Engn, IEEE Comp Soc DE complex networks; terrorism; algorithms; sociology AB Security organizations often attempt to disrupt terror or insurgent networks by targeting "high value targets" (HVT's). However, there have been numerous examples that illustrate how such networks are able to quickly re-generate leadership after such an operation. Here, we introduce the notion of a shaping operation in which the terrorist network is first targeted for the purpose of reducing its leadership re-generation ability before targeting HVT's. We look to conduct shaping by maximizing the network-wide degree centrality through node removal. We formally define this problem and prove solving it is NP-Complete. We introduce a greedy heuristic for to approximate this problem. We implement the greedy heuristic and found in examining five real-world terrorist networks that removing only 12% of nodes can increase the network-wide centrality between 17% and 45%. C1 [Callahan, Devon; Shakarian, Paulo; Nielsen, Jeffrey; Johnson, Anthony N.] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. RP Callahan, D (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. EM devon.callahan@usma.edu; paulo@shakarian.net; jeffrey.nielsen@usma.edu; anthony.johnson@usma.edu NR 16 TC 2 Z9 2 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-5015-2 PY 2012 BP 13 EP 18 DI 10.1109/SocialInformatics.2012.22 PG 6 WC Computer Science, Information Systems; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BGZ84 UT WOS:000324764400003 ER PT B AU Jankowski, NR McCluskey, FP AF Jankowski, Nicholas R. McCluskey, F. Patrick GP ASME TI NUMERICAL STUDY ON THE THERMAL PERFORMANCE OF A SUBSTRATE INTEGRATED THERMAL BUFFER HEAT SINK SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2011, VOL 10, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn ID POWER ELECTRONICS; MANAGEMENT AB This report describes a parametric numerical study of a substrate integrated Thermal Buffer Heat Sink (TBHS) used to reduce transient temperature rise of power electronic devices. Linear and non-linear finite element models of the substrate unit cell are developed including a polynomial smoothing function to approximate phase change using the apparent capacity method (ACM). Parameters investigated include substrate geometry, convection rate and heat load. These parameters are examined for steady state and transient thermal loading conditions, and substrate thermal performance is evaluated for each case. Specifically the TBHS design tradeoff between thermal resistance and thermal capacity is quantified, and the ability of the TBHS structure to reduce peak temperature rise for certain transient load conditions is evaluated. It is demonstrated that for short thermal transients a particular TBHS design can suppress temperature rise by 19.6 degrees C (35%) when compared to an equivalent standard microchannel heat sink. C1 [Jankowski, Nicholas R.] US Army Res Lab, Adelphi, MD USA. RP Jankowski, NR (reprint author), US Army Res Lab, Adelphi, MD USA. NR 20 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5496-9 PY 2012 BP 687 EP 696 PG 10 WC Engineering, Mechanical SC Engineering GA BGZ59 UT WOS:000324716800086 ER PT B AU Boettner, DD Bluman, J Rowland, M Bodenhamer, J Arnas, AOO AF Boettner, Daisie D. Bluman, James Rowland, Matthew Bodenhamer, Jonathan Arnas, A. Oezer GP ASME TI GRAPHICAL INTERPRETATION OF EXERGY SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2011, VOL 5 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn AB Exergy is a system thermodynamic property defined only with respect to the system's surroundings. For a specified system state, exergy is the maximum potential useful work available from the system as it achieves equilibrium with the surroundings. For students exergy can be a very abstract concept. This paper presents a graphical means to clarify the concept of exergy for a closed system, demonstrating exergy at any state i corresponds to the sum of the net work of a power cycle that incorporates a process from system state i to the dead state and the net work of a refrigeration/heat pump cycle required to move the system from the dead state to state i. C1 [Boettner, Daisie D.; Bluman, James; Rowland, Matthew; Bodenhamer, Jonathan; Arnas, A. Oezer] United States Mil Acad, West Point, NY USA. RP Boettner, DD (reprint author), United States Mil Acad, West Point, NY USA. NR 7 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5491-4 PY 2012 BP 73 EP 83 PG 11 WC Education, Scientific Disciplines; Engineering, Mechanical SC Education & Educational Research; Engineering GA BGZ18 UT WOS:000324656200010 ER PT B AU Rogers, JR Avdashchenko, K AF Rogers, John R. Avdashchenko, Konstantin GP ASME TI TEACHING MICROCONTROLLER PROGRAMMING GRAPHICALLY SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2011, VOL 5 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn AB The ability to develop algorithms for microcontroller-based systems has traditionally required a computer science background. Many undergraduate mechanical engineering programs lack the time in the curriculum to devote to the necessary coursework. This paper presents a graphical method of developing algorithms. The method enables engineering students with weak computer science backgrounds to rapidly iterate microcontroller programs. The proposed method uses Simulink and chip-specific Simulink blocksets to access microcontroller inputs, outputs, internal timers, and other chip functions. Before- and after- observations from the implementation of the method in a mechatronics course are presented. The proposed method is compared to the traditional C language method of developing an algorithm. It is shown that it is easier to convey the algorithm in the Simulink implementation than it is to convey the C-language implementation of the same algorithm. It is quicker to develop algorithms using the Simulink-based method. The method is relevant in constrained undergraduate engineering programs, particularly mechanical engineering, where there is little instruction in computer programming. The method is scalable to industrial applications outside academia although it is not yet widely used there. C1 [Rogers, John R.; Avdashchenko, Konstantin] US Mil Acad, West Point, NY 10996 USA. RP Rogers, JR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5491-4 PY 2012 BP 117 EP 121 PG 5 WC Education, Scientific Disciplines; Engineering, Mechanical SC Education & Educational Research; Engineering GA BGZ18 UT WOS:000324656200015 ER PT B AU Floersheim, B Klosky, JL Flynn, M AF Floersheim, Bruce Klosky, J. Ledlie Flynn, Matthew GP ASME TI A Framework for Integrating Design Education, Research and Outreach; the Center for Innovation and Engineering at West Point SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, 2011, VOL 5 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 11-17, 2011 CL Denver, CO SP Amer Soc Mech Engn AB The Department of Civil and Mechanical Engineering at West Point has recently established a multi-disciplinary research and educational outreach center that has a two-fold mission: enhance the undergraduate educational experience of students and assist in solving real-world technical problems, supporting global Army operations. This is accomplished by tying projects directly to the undergraduate education mission and gaining efficiency by consolidating administrative and outreach functions for multiple existing research programs. The paper describes the Center for Innovation and Engineering (CIE), its lines of effort, and several past and current initiatives. Assessment data from students participating in the senior capstone design course, which is closely tied to the CIE, reinforces the importance of multidisciplinary, client-based projects in the engineering education experience. C1 [Floersheim, Bruce; Klosky, J. Ledlie; Flynn, Matthew] US Mil Acad, West Point, NY 10996 USA. RP Floersheim, B (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 9 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5491-4 PY 2012 BP 403 EP 408 PG 6 WC Education, Scientific Disciplines; Engineering, Mechanical SC Education & Educational Research; Engineering GA BGZ18 UT WOS:000324656200049 ER PT J AU Erbacher, RF AF Erbacher, Robert F. BE Schweitzer, D Quist, D Goodall, JR TI Visualization Design for Immediate High-Level Situational Assessment SO VIZSEC 2012: PROCEEDINGS OF THE NINTH INTERNATIONAL SYMPOSIUM ON VISUALIZATION FOR CYBER SECURITY LA English DT Proceedings Paper CT 9th International Symposium on Visualization for Cyber Security (VizSec) CY OCT 15, 2012 CL VisWeek, Seattle, WA HO VisWeek DE Situational Awareness; Decision Makers; Cyber Security ID AWARENESS AB We present the design of a visualization technique based on the results of a human in the loop process, which relied on network managers and network analysts. This visualization design was directly targeted at supporting tasks identified by the domain experts. This was the need for the ability to provide rapid and immediate assessment of the state of the network and associated hosts. This visualization technique, the Cyber Command Gauge Cluster (CCGC), allows analysts to review the state of the network and locate potentially problematic anomalies, drill down into those anomalies, and prioritize the anomalies for detailed analysis and remediation. By providing a summary representation combined with independent representations of critical parameters, the technique is unique in its ability to aid decision makers in making rapid assessments and prioritization of identified anomalies. While the prototype focuses on network analysis, the technique is devised to provide generalized support for situational awareness in any domain. The generalized parameter mapping allows the technique to be applicable to any level of decision making, from the front-line network analyst to the CIO. C1 US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD USA. RP Erbacher, RF (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD USA. EM Robert.F.Erbacher.civ@mail.mil NR 19 TC 5 Z9 6 U1 1 U2 3 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036-9998 USA BN 978-1-4503-1413-8 PY 2012 BP 17 EP 24 PG 8 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA BGU28 UT WOS:000324160000003 ER PT B AU Troiano, E Parker, AP Izzo, JH AF Troiano, E. Parker, A. P. Izzo, J. H. GP ASME TI INFLUENCE AND MODELING OF RESIDUAL STRESSES IN THICK WALLED PRESSURE VESSELS WITH THROUGH HOLES SO PROCEEDINGS OF THE ASME PRESSURE VESSELS AND PIPING CONFERENCE, PVP 2012, VOL 5: HIGH-PRESSURE TECHNOLOGY NONDESTRUCTIVE EVALUATION DIVISION LA English DT Proceedings Paper CT ASME Pressure Vessels and Piping Conference CY JUL 15-19, 2012 CL Toronto, CANADA SP ASME, Pressure Vessels & Piping Div AB Thick walled pressure vessels are often autofrettaged in order to impart favorable near bore compressive residual stresses which can significantly increase the life of the vessels. These stresses can be imparted via: a thermal shrink process in which there is no loss of residual stresses due to the Bauschinger Effect, or more economically with a mechanical swage or hydraulic overload process in which the Bauschinger Effect is present. In some cases these vessels have holes bored through the wall in order to take advantage of the escaping gasses for actuation of external peripherals associated with the vessel. These through holes, which can be angled or perpendicular to the centerline of the pressure vessel can significantly reduce the fatigue life of the vessel depending on the wall ratio of the vessel as well as the, angle of inclination of the hole to the centerline of the vessel. This study utilizes the classic stress based Paris Law fatigue life approach which takes into account the residual stresses as a function of radial location to assess the life of the vessel in the region of both configurations of through holes. It quantifies the concentration of stresses associated with the perpendicular and angled through wall holes, and the amount of pressure that actually enters the hole. The analysis is employed to ensure that the life within these through holes meets or exceeds the safe life of the vessel without holes which has been determined by assuming a log normal distribution from of a sample size of six with the 90% lower confidence bound on the 0.1th percentile of the population. C1 [Troiano, E.; Izzo, J. H.] US Army Benet Labs, Watervliet, NY 12189 USA. RP Troiano, E (reprint author), US Army Benet Labs, Watervliet, NY 12189 USA. EM edward.j.troiano.civ@mail.mil; parker.ETR@tiscali.co.uk; john.h.izzo.civ@mail.mil NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5504-1 PY 2012 BP 205 EP 211 PG 7 WC Engineering, Mechanical; Physics, Applied SC Engineering; Physics GA BGR21 UT WOS:000323865900028 ER PT B AU Underwood, JH AF Underwood, John H. GP ASME TI KENDALL ANALYSIS OF CANNON PRESSURE VESSELS SO PROCEEDINGS OF THE ASME PRESSURE VESSELS AND PIPING CONFERENCE, PVP 2012, VOL 5: HIGH-PRESSURE TECHNOLOGY NONDESTRUCTIVE EVALUATION DIVISION LA English DT Proceedings Paper CT ASME Pressure Vessels and Piping Conference CY JUL 15-19, 2012 CL Toronto, CANADA SP ASME, Pressure Vessels & Piping Div ID TUBES AB Engineering Mechanics analysis of cannon pressure vessels is described with special emphasis on the work of the late US Army Benet Laboratories engineer David P. Kendall. His work encompassed a broad range of design and analysis of high pressure vessels for use as cannons, including analysis of the limiting yield pressure for vessels, the autofrettage process applied to thick vessels, and the fatigue life of autofrettaged cannon vessels. Mr. Kendall's work has become the standard approach used to analyze the structural integrity of cannon pressure vessels at the US Army Benet Laboratories. The methods used by Kendall in analysis of pressure vessels were simple and direct. He used classic results from research in engineering mechanics to develop descriptive expressions for limiting pressure, autofrettage residual stresses and fatigue life of cannon pressure vessels. Then he checked the expressions against the results of full-scale cannon pressure vessel tests in the proving grounds and the laboratory. Three types of analysis are described: [i] Yield pressure tests of cannon sections compared with a yield pressure expression, including in the comparison post-test yield strength measurements from appropriate locations of the cannon sections; [ii] Autofrettage hoop residual stress measurements by neutron diffraction in cannon sections compared with expressions, including Bauschinger corrections in the expressions to account for the reduction in compressive yield strength near the bore of an autofrettaged vessel; [iii] Fatigue life tests of cannons following proving ground firing and subsequent laboratory simulated firing compared with Paris-based fatigue life expressions that include post-test metallographic determination of the initial crack size due to firing. Procedures are proposed for Paris life calculations for bore-initiated fatigue affected by crack-face pressure and notch-initiated cracking in which notch tip stresses are significantly above the material yield strength. The expressions developed by Kendall and compared with full-scale cannon pressure vessel tests provide useful first-order design and safety checks for pressure vessels, to be followed by further engineering analysis and service simulation testing as appropriate for the application. Expressions are summarized that are intended for initial design calculations of yield pressure, autofrettage stresses and fatigue life for pressure vessels. Example calculations with these expressions are described for a hypothetical pressure vessel. C1 US Army Benet Labs, Watervliet, NY 12189 USA. RP Underwood, JH (reprint author), US Army Benet Labs, Watervliet, NY 12189 USA. EM treaclemine@hughes.net NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5504-1 PY 2012 BP 221 EP 227 PG 7 WC Engineering, Mechanical; Physics, Applied SC Engineering; Physics GA BGR21 UT WOS:000323865900030 ER PT J AU Chan, RK Zamora, DO Wrice, NL Baer, DG Renz, EM Christy, RJ Natesan, S AF Chan, Rodney K. Zamora, David O. Wrice, Nicole L. Baer, David G. Renz, Evan M. Christy, Robert J. Natesan, Shanmugasundaram TI Development of a Vascularized Skin Construct Using Adipose-Derived Stem Cells from Debrided Burned Skin SO STEM CELLS INTERNATIONAL LA English DT Article ID CULTURED EPITHELIAL AUTOGRAFTS; OPERATION ENDURING FREEDOM; IRAQI FREEDOM; PORCINE MODEL; REGENERATION; TISSUE; SUBSTITUTES; MATRIX; WOUNDS; REPAIR AB Large body surface area burns pose significant therapeutic challenges. Clinically, the extent and depth of burn injury may mandate the use of allograft for temporary wound coverage while autografts are serially harvested from the same donor areas. The paucity of donor sites in patients with burns involving large surface areas highlights the need for better skin substitutes that can achieve early and complete coverage and retain normal skin durability with minimal donor requirements. We have isolated autologous stem cells from the adipose layer of surgically debrided burned skin (dsASCs), using a point-of-care stem cell isolation device. These cells, in a collagen-polyethylene glycol fibrin-based bilayer hydrogel, differentiate into an epithelial layer, a vascularized dermal layer, and a hypodermal layer. All-trans-retinoic acid and fenofibrate were used to differentiate dsASCs into epithelial-like cells. Immunocytochemical analysis showed a matrix-and time-dependent change in the expression of stromal, vascular, and epithelial cell markers. These results indicate that stem cells isolated from debrided skin can be used as a single autologous cell source to develop a vascularized skin construct without culture expansion or addition of exogenous growth factors. This technique may provide an alternative approach for cutaneous coverage after extensive burn injuries. C1 [Chan, Rodney K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Zamora, David O.; Wrice, Nicole L.; Baer, David G.; Christy, Robert J.; Natesan, Shanmugasundaram] US Army, Inst Surg Res, Dept Extrem Trauma Res & Regenerat Med, Ft Sam Houston, TX 78234 USA. [Renz, Evan M.] US Army, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Natesan, S (reprint author), US Army, Inst Surg Res, Dept Extrem Trauma Res & Regenerat Med, Ft Sam Houston, TX 78234 USA. EM natesan.shanmugasundaram@amedd.army.mil OI Zamora, David/0000-0002-7003-5933; Natesan, Shanmugasundaram/0000-0003-4213-3111 FU Pittsburgh Tissue Engineering Initiative (PTEI); Geneva Foundation FX The authors would like to thank CPT Laura McGhee and Mr. Thomas Garza for collection of debrided tissue, Ms. Sandra Becerra for her technical support, and Ms. Karla Moncada for providing technical support in cell sorting. Flow cytometry data was generated in the core flow cytometry facility, which is supported by the University of Texas Health Science Center San Antonio and NIH-NCI P30 CA054174 (Cancer Therapy and Research Center). S. Natesan is supported by the Pittsburgh Tissue Engineering Initiative (PTEI). D. O. Zamora is supported by a grant awarded by The Geneva Foundation. NR 52 TC 7 Z9 7 U1 1 U2 7 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-966X J9 STEM CELLS INT JI Stem Cells Int. PY 2012 AR UNSP 841203 DI 10.1155/2012/841203 PG 11 WC Cell & Tissue Engineering SC Cell Biology GA 209TA UT WOS:000323781700001 ER PT J AU Klassen, H Tucker, BA Liew, CG La Cour, M Wang, HC AF Klassen, Henry Tucker, Budd A. Liew, Chee G. La Cour, Morten Wang, Heuy-Ching TI Stem Cells in Large Animal Models of Retinal and Neurological Disease SO STEM CELLS INTERNATIONAL LA English DT Editorial Material C1 [Klassen, Henry] Univ Calif Irvine, Gavin Herbert Eye Inst, Irvine, CA 92697 USA. [Klassen, Henry] Univ Calif Irvine, Stem Cell Res Ctr, Irvine, CA 92697 USA. [Tucker, Budd A.] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA. [Liew, Chee G.] Univ Calif Riverside, Stem Cell Core, Riverside, CA 92521 USA. [La Cour, Morten] Univ Copenhagen, Glostrup Hosp, Dept Ophthalmol, DK-2600 Glostrup, Denmark. [Wang, Heuy-Ching] US Army Inst Surg Res, Ocular Trauma Div, Ft Sam Houston, TX 78234 USA. RP Klassen, H (reprint author), Univ Calif Irvine, Gavin Herbert Eye Inst, Irvine, CA 92697 USA. EM hklassen@uci.edu OI Tucker, Budd/0000-0003-2178-1742 NR 6 TC 0 Z9 0 U1 0 U2 1 PU HINDAWI PUBLISHING CORPORATION PI NEW YORK PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA SN 1687-966X J9 STEM CELLS INT JI Stem Cells Int. PY 2012 AR UNSP 460504 DI 10.1155/2012/460504 PG 2 WC Cell & Tissue Engineering SC Cell Biology GA 209SS UT WOS:000323780900001 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Environmental Assessment in Engineering and Planning SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 1 EP 17 PG 17 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200002 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT Strategy, Planning, and Management PREFACE SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Editorial Material; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP IX EP + PG 18 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200001 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Environmental Laws and Regulations SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 19 EP 65 PG 47 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200003 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI National Environmental Policy Act SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 67 EP 91 PG 25 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200004 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Environmental Documents and CEQ Regulations SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 93 EP 135 PG 43 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200005 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Elements of Environmental Assessment and Planning SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 137 EP 176 PG 40 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200006 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Environmental Assessment Methodologies SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 177 EP 209 PG 33 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200007 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Generalized Approach for Environmental Assessment SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 211 EP 224 PG 14 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200008 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Procedure for Reviewing Environmental Impact Statements SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 225 EP 244 PG 20 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200009 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI International Perspectives on Environmental Assessment, Engineering, and Planning SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 245 EP 263 PG 19 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200010 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Economic and Social Impact Analysis SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 265 EP 309 PG 45 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200011 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Public Participation SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 311 EP 337 PG 27 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200012 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Energy and Environmental Implications SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 339 EP 360 PG 22 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200013 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Contemporary Issues in Environmental Assessment SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 1 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 361 EP 447 PG 87 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200014 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI National Environmental Policy Act SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 449 EP 458 PG 10 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200015 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Attribute Descriptor Package SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 459 EP 642 PG 184 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200016 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI A Step-by-Step Procedure for Preparing Environmental Assessments and Statements SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 643 EP 661 PG 19 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200017 ER PT J AU Jain, R Urban, L Stacey, GS Balbach, H Webb, MD AF Jain, Ravi Urban, Lloyd Stacey, Gary S. Balbach, Harold Webb, M. Diana BA Jain, R Urban, L Stacey, GS Balbach, H Webb, MD BF Jain, R Urban, L Stacey, GS Balbach, H Webb, MD TI Regulations for Implementing Procedural Provisions of the National Environmental Policy Act SO HANDBOOK OF ENVIRONMENTAL ENGINEERING ASSESSMENT: STRATEGY, PLANNING, AND MANAGEMENT LA English DT Article; Book Chapter C1 [Jain, Ravi] Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. [Urban, Lloyd] Texas Tech Univ, Water Resources Ctr, Lubbock, TX 79409 USA. [Urban, Lloyd] Texas Tech Univ, Lubbock, TX 79409 USA. [Balbach, Harold] US Army Engn Res & Dev Ctr, Champaign, IL USA. [Webb, M. Diana] Los Alamos Natl Lab, Ecol Grp, Los Alamos, NM 87545 USA. [Webb, M. Diana] Los Alamos Natl Lab, Policy Off, Los Alamos, NM 87545 USA. RP Jain, R (reprint author), Univ Pacific, Sch Engn & Comp Sci, Stockton, CA 95211 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER BUTTERWORTH-HEINEMANN PI BURLINGTON PA 30 CORPORATE DRIVE, STE 400, BURLINGTON, MA 01803 USA BN 978-0-12-388445-9 PY 2012 BP 663 EP 722 PG 60 WC Engineering, Environmental SC Engineering GA BFZ64 UT WOS:000321980200018 ER PT S AU O'Brien, H Shaheen, W Ogunniyi, A Temple, V Scozzie, CJ AF O'Brien, Heather Shaheen, William Ogunniyi, Aderinto Temple, Victor Scozzie, Charles J. BE Hegeler, F TI Compact Silicon SGTO Module for Pulse Switching beyond 6 kV, 100 kA SO PROCEEDINGS OF THE 2012 IEEE INTERNATIONAL POWER MODULATOR AND HIGH VOLTAGE CONFERENCE SE IEEE International Power Modulator and High Voltage Conference LA English DT Proceedings Paper CT IEEE International Power Modulator and High Voltage Conference (IPMHVC) CY JUN 03-07, 2012 CL San Diego, CA SP IEEE, IEEE Dielectr & Elect Insulat Soc, IEEE Nucl & Plasma Sci Soc, IEEE Electron Devices Soc, Sandia Natl Labs, Dept Navy, Naval Res Lab, GE, INP Greifswald, L3 Appl Technologies, Pulse Sci, Lockheed Martin, Ness Engn Inc DE power semiconductor switches; thyristors; pulse shaping circuits AB In a continuing effort to reduce the weight and volume of high-power pulse switches, the U. S. Army Research Laboratory and Silicon Power Corp. have developed new Super-GTO-based switch modules that out-perform previous designs while maintaining compact size. These switch modules have recently been demonstrated at a 50% increase in hold-off voltage and 30% increase in pulse current (compared to switches presented at PMC 2006) while utilizing the same area of silicon in the same volume packaging. Each switch module is composed of eight parallel 3.5 cm(2) silicon Super-GTOs, for a total silicon area of 28 cm(2) and a package volume of 0.14 L. The pulse performance at the individual Super-GTO device level was improved by modifying the emitter layout and metallization to reduce on-state resistance and maximize current-spreading across the silicon area. Modules were pulsed over 110 kA for 500 pulses with consistent pulse performance. C1 [O'Brien, Heather; Ogunniyi, Aderinto; Scozzie, Charles J.] US Army, Res Lab, Adelphi, MD 20783 USA. RP O'Brien, H (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 4 TC 1 Z9 1 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2380-808X BN 978-1-4673-1225-7; 978-1-4673-1222-6 J9 IEEE INT POWER MODUL PY 2012 BP 14 EP 18 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BGB05 UT WOS:000322131200003 ER PT S AU Ogunniyi, A O'Brien, H Scozzie, CJ Shaheen, W Agarwal, A Cheng, L Temple, V AF Ogunniyi, Aderinto O'Brien, Heather Scozzie, Charles J. Shaheen, William Agarwal, Anant Cheng, Lin Temple, Victor BE Hegeler, F TI DV/DT Immunity and Recovery Time Capability of 1.0 cm(2) Silicon Carbide SGTO SO PROCEEDINGS OF THE 2012 IEEE INTERNATIONAL POWER MODULATOR AND HIGH VOLTAGE CONFERENCE SE IEEE International Power Modulator and High Voltage Conference LA English DT Proceedings Paper CT IEEE International Power Modulator and High Voltage Conference (IPMHVC) CY JUN 03-07, 2012 CL San Diego, CA SP IEEE, IEEE Dielectr & Elect Insulat Soc, IEEE Nucl & Plasma Sci Soc, IEEE Electron Devices Soc, Sandia Natl Labs, Dept Navy, Naval Res Lab, GE, INP Greifswald, L3 Appl Technologies, Pulse Sci, Lockheed Martin, Ness Engn Inc DE thyristor; power semiconductor switches; device under test; resistance-capacitance AB The silicon carbide SGTO is a future switching component technology of interest to the Army for various pulsed power applications. The research presented in this paper investigates the dV/dt immunity and recovery time (T-q) capability of 1.0 cm(2) silicon carbide (SiC) super gate turn-off thyristors (SGTOs). The 1.0 cm(2) SiC SGTO is the largest chip based silicon carbide thyristor reported. The SiC SGTO was designed by SPCO and Cree Inc., while the fabrication was done by Cree Inc. This work highlights improved results for both the recovery time and transient voltage immunity compared to the smaller SiC GTO that was previously reported at PPC 2009. The pulse evaluation results in this work show that the SiC SGTO did not require assisted gate turn-off and achieved a recovery time less than 25 mu s after a 1-ms wide current pulse current of 1.7 kA, corresponding to an action level of 1.445 x 10(3) A(2)s. Finally, the SiC SGTO was evaluated for dV/dt immunity with an instantaneous rise time greater than 9 kV/mu s. C1 [Ogunniyi, Aderinto; O'Brien, Heather; Scozzie, Charles J.] US Army Res Lab, Adelphi, MD 20783 USA. RP Ogunniyi, A (reprint author), US Army Res Lab, Adelphi, MD 20783 USA. NR 6 TC 1 Z9 1 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2380-808X BN 978-1-4673-1225-7; 978-1-4673-1222-6 J9 IEEE INT POWER MODUL PY 2012 BP 354 EP 357 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BGB05 UT WOS:000322131200088 ER PT S AU Ho, J Jow, TR AF Ho, Janet Jow, T. Richard BE Hegeler, F TI High Field Conduction in Heat Resistant Polymers at Elevated Temperature for Metallized Film Capacitors SO PROCEEDINGS OF THE 2012 IEEE INTERNATIONAL POWER MODULATOR AND HIGH VOLTAGE CONFERENCE SE IEEE International Power Modulator and High Voltage Conference LA English DT Proceedings Paper CT IEEE International Power Modulator and High Voltage Conference (IPMHVC) CY JUN 03-07, 2012 CL San Diego, CA SP IEEE, IEEE Dielectr & Elect Insulat Soc, IEEE Nucl & Plasma Sci Soc, IEEE Electron Devices Soc, Sandia Natl Labs, Dept Navy, Naval Res Lab, GE, INP Greifswald, L3 Appl Technologies, Pulse Sci, Lockheed Martin, Ness Engn Inc DE Metalized film capacitors; high temperature polymers; electrical conductivity; charge injection; transport mechanisms ID ELECTRICAL-CONDUCTION; POLYETHYLENE; POLYPROPYLENE; TRANSPORT AB Improved high temperature polymeric dielectrics are in demand for applications such as hybrid electric vehicles, advance aircraft, and deep oil/gas well drilling. Metallized polymeric film capacitors have the advantage of graceful failure as a result of self-healing. As no dielectrics are perfect insulators, trace amount of electrical conduction is always present, especially at high electric field and/or elevated temperature. In this work, high field conductivity and conduction mechanisms of polyphenylene sulfide (PPS) and polyethylene terephthalate (PET) were investigated. Results suggest charge injection through Schottky mechanism and conduction through hopping in both polymers. The average activation energies of PPS and PET were 0.90 and 1.03 eV, respectively. C1 [Ho, Janet; Jow, T. Richard] US Army, Res Lab, Adelphi, MD 20783 USA. RP Ho, J (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. NR 12 TC 0 Z9 0 U1 1 U2 6 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2380-808X BN 978-1-4673-1225-7; 978-1-4673-1222-6 J9 IEEE INT POWER MODUL PY 2012 BP 399 EP 402 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BGB05 UT WOS:000322131200099 ER PT S AU Lammers, MO Small, R Atkinson, S Castellote, M Jenniges, J Rosinski, A Moore, S Garner, C Au, WWL AF Lammers, Marc O. Small, Robert Atkinson, Shannon Castellote, Manuel Jenniges, Justin Rosinski, Anne Moore, Sue Garner, Chris Au, Whitlow W. L. BE Popper, AN Hawkins, A TI Acoustic Monitoring of Beluga Whales (Delphinapterus leucas) in Cook Inlet, Alaska SO EFFECTS OF NOISE ON AQUATIC LIFE SE Advances in Experimental Medicine and Biology LA English DT Article C1 [Lammers, Marc O.; Rosinski, Anne; Au, Whitlow W. L.] Hawaii Inst Marine Biol, Kaneohe, HI 96744 USA. [Small, Robert] Alaska Dept Fish & Game, Juneau, AK 99811 USA. [Atkinson, Shannon] Univ Alaska Fairbanks, Sch Fisheries & Ocean Sci, Juneau Fisheries, Juneau, AK 99801 USA. [Castellote, Manuel; Moore, Sue] NOAA, Natl Marine Mammal Lab, Seattle, WA 98115 USA. [Jenniges, Justin] Alaska SeaLife Ctr, Seward, AK 99664 USA. [Garner, Chris] US Army, Ft Richardson, AK 99505 USA. RP Lammers, MO (reprint author), Hawaii Inst Marine Biol, Kaneohe, HI 96744 USA. EM lammers@hawaii.edu; bob.small@alaska.gov; atkinson@sfos.uaf.edu; Manuel.Castellote@noaa.gov; justinj@alaskasealife.org; christopher.d.garner@us.army.mil NR 2 TC 1 Z9 1 U1 2 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4419-7310-8 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 730 BP 341 EP 344 DI 10.1007/978-1-4419-7311-5_77 PG 4 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BFV95 UT WOS:000321592700077 PM 22278514 ER PT S AU Hoffman, CA AF Hoffman, Christopher A. BE Popper, AN Hawkins, A TI Mitigating Impacts of Underwater Noise From Dredging on Beluga Whales in Cook Inlet, Alaska SO EFFECTS OF NOISE ON AQUATIC LIFE SE Advances in Experimental Medicine and Biology LA English DT Article C1 US Army Corps Engineers, Elmendorf AFB, AK 99506 USA. RP Hoffman, CA (reprint author), US Army Corps Engineers, Elmendorf AFB, AK 99506 USA. EM Christopher.A.Hoffman@usace.army.mil NR 4 TC 0 Z9 0 U1 1 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4419-7310-8 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 730 BP 617 EP 619 DI 10.1007/978-1-4419-7311-5_140 PG 3 WC Biology; Medicine, Research & Experimental SC Life Sciences & Biomedicine - Other Topics; Research & Experimental Medicine GA BFV95 UT WOS:000321592700140 PM 22278577 ER PT B AU Sharar, DJ Morgan, B Jankowski, NR Bar-Cohen, A AF Sharar, Darin J. Morgan, Brian Jankowski, Nicholas R. Bar-Cohen, Avram GP ASME TI TWO-PHASE MINICHANNEL COLD PLATE FOR ARMY VEHICLE POWER ELECTRONICS SO PROCEEDINGS OF THE ASME PACIFIC RIM TECHNICAL CONFERENCE AND EXHIBITION ON PACKAGING AND INTEGRATION OF ELECTRONIC AND PHOTONIC SYSTEMS, MEMS AND NEMS 2011, VOL 2 LA English DT Proceedings Paper CT ASME Pacific Rim Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Systems, MEMS and NEMS CY JUL 06-08, 2011 CL Portland, OR SP ASME, Japan Soc Mech Engineers ID HEAT-TRANSFER; FLOW AB Army programs have focused on increasing the use of power-dense electronic components to improve system weight, fuel usage, design flexibility, and overall functionality, thus, stressing the thermal management requirements. Recent cooling designs focused on flowing 80-100 degrees C engine coolant through single-phase microchannel cold plates but concern over pumping power, heat dissipation, cold plate temperature inconsistency, and contaminate clogging have prompted interest in two-phase flow in a minichannel cold plate. In the course of this study, both single- and two-phase experiments were conducted with a 6.8 x 2.7 x 0.9 cm offset fin minichannel cold plate using 25 degrees C, 80 degrees C, and 99 degrees C de-mineralized water, respectively, with flowrates ranging from 0.33 cm(3)/s to 45 cm(3)/s. Heat dissipation using solder attached chip resistors was incrementally increased from 0 W to more than 1000 W while simultaneously measuring cold plate pressure drop, chip surface temperature, inlet and outlet fluid temperature, and flowrate. Preliminary results indicate that utilizing a minichannel cold plate with two-phase heat transfer offers the ability to significantly reduce clogging potential, flowrate, and associated pumping power, while improving thermal resistivity by more than a factor of 4 and temperature consistency by greater than a factor of 10. Single- and two-phase correlations were used to compare performance with theoretical values. C1 [Sharar, Darin J.] Gen Tech Serv, Wall, NJ USA. [Morgan, Brian; Jankowski, Nicholas R.] Army Res Lab, Adelphi, MD USA. [Bar-Cohen, Avram] Univ Maryland, College Pk, MD USA. RP Sharar, DJ (reprint author), Gen Tech Serv, Wall, NJ USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4462-5 PY 2012 BP 133 EP + PG 3 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA BFJ70 UT WOS:000320140400015 ER PT S AU Acosta, JC Mendoza, H Medina, BG AF Acosta, Jaime C. Mendoza, Humberto Medina, Brenda G. GP IEEE TI An Efficient Common Substrings Algorithm for On-the-Fly Behavior-Based Malware Detection and Analysis SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc AB It is well known that malware (worms, botnets, etc...) thrive on communication systems. The process of detecting and analyzing malware is very latent and not well-suited for real-time application, which is critical especially for propagating malware. For this reason, recent methods identify similarities among malware dynamic trace logs to extract malicious behavior snippets. These snippets can then be tagged by a human analyst and be used to identify malware on-the-fly. A major problem with these methods is that they require extensive processing resources. This is especially due to the large amount of malware released each year (upwards of 17 million new instances in 2011). In this paper, we present an efficient algorithm for identifying common substrings in dynamic trace events of malware collections. The algorithm finds common substrings between malware pairs in theoretical linear time by using parallel processing. The algorithm is implemented in the CUDA and results show a performance increase of up to 8 times compared to previous implementations. C1 [Acosta, Jaime C.; Mendoza, Humberto; Medina, Brenda G.] USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Acosta, JC (reprint author), USA, Res Lab, White Sands Missile Range, NM 88002 USA. NR 15 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900259 ER PT S AU Acosta, JC Medina, BG AF Acosta, Jaime C. Medina, Brenda G. GP IEEE TI Survivability Prediction of Ad Hoc Networks Under Attack SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc ID ROUTING PROTOCOLS AB Survivability analysis focuses on the ability of network entities to function during incidents such as attacks. Currently, testing survivability of ad hoc networks consists of running scenarios with several configurations, often thousands, to obtain an understanding of the impacts of an attack. This process is very latent, choice of configurations are subjective or random, and results do not generalize to different scenarios. Focusing on these problems, in this paper, we introduce a novel method for efficient survivability analysis that uses machine learning and an attacker-focused network representation. We have collected a dataset and use it to build a classifier that accurately (above 97% true positive rate) predicts flow loss due to spoofing and data forwarding attacks. C1 [Acosta, Jaime C.; Medina, Brenda G.] USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Acosta, JC (reprint author), USA, Res Lab, White Sands Missile Range, NM 88002 USA. NR 24 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900186 ER PT S AU Beal, AN Bailey, JP Hale, SA Dean, RN Hamilton, M Tugnait, JK Hahs, DW Corron, NJ AF Beal, A. N. Bailey, J. P. Hale, S. A. Dean, R. N. Hamilton, M. Tugnait, J. K. Hahs, D. W. Corron, N. J. GP IEEE TI Design and Simulation of a High Frequency Exact Solvable Chaotic Oscillator SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Chaotic Oscillator; Spread Spectrum; Matched Filter Decoding ID COMMUNICATION AB It has been shown that the performance of communication systems based on low dimensional chaotic systems with exact analytic solutions containing a single fixed basis function may exhibit performance comparable to that of nonchaotic systems. Previously, novel low frequency (LF) oscillators exhibiting solvable, chaotic behavior have been proposed, although the generation of low frequency signals has limited applicability in the field of communications. These limitations motivate the development of similarly solvable, chaotic oscillators that operate in high frequency (HF) bands (>1MHz). The design and simulation of a HF exactly solvable chaotic oscillator has been submitted. The behavior of this oscillator, although chaotic, is solvable, giving rise to encoding or encryption applications. This oscillator may be encoded by means of small perturbation control known as Hayes type chaos communications. Furthermore, it has been shown that symbolic information encoded with oscillators of this topology may be extracted accurately and elegantly through means of matched filter decoding. C1 [Beal, A. N.; Bailey, J. P.; Hale, S. A.; Dean, R. N.; Hamilton, M.; Tugnait, J. K.] Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. [Hahs, D. W.] Torch Technol, Huntsville, AL 35802 USA. [Corron, N. J.] US Army RDECOM, Redstone Arsenal, AL USA. RP Beal, AN (reprint author), Auburn Univ, Dept Elect & Comp Engn, Auburn, AL 36849 USA. EM anb0011@auburn.edu; bailejp@auburn.edu; sah0033@auburn.edu; deanron@auburn.edu; mch0021@auburn.edu; tugnajk@auburn.edu; dan.hahs@torchtechnologies.com; ned.corron@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900243 ER PT S AU Benincasa, G Casini, E Lenzi, R Morelli, A Benvegnu, E Suri, N Boner, K Watson, S AF Benincasa, G. Casini, E. Lenzi, R. Morelli, A. Benvegnu, E. Suri, N. Boner, K. Watson, S. GP IEEE TI Extending Service-oriented Architectures to the Tactical Edge SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Service-oriented Architectures; Tactical Networks; Information Dissemination; Quality of Information AB Service Oriented Architectures allow for seamless integration of heterogeneous systems and extensive service reuse; characteristics that led to a wide adoption of this paradigm in the enterprise and military environment. While So As are currently deployed in tactical environments mainly at higher-echelon levels, it is necessary to allow for the exchange of information all the way down to the edge nodes deployed on the ground and back. Because most So As implementations were designed to work on reliable infrastructure networks, porting SoAs to the tactical environment requires a complete redesign of the protocol stack to support unreliable, transiently disconnected networks. In this paper, we present our approach to integrate the U.S. Marine Corps's Marine Command and Control Systems and Applications SoA (MC2SA SoA) with DisServicePro, a middleware that supports proactive dissemination and information on demand in tactical edge networks. C1 [Benincasa, G.; Casini, E.; Lenzi, R.; Morelli, A.; Benvegnu, E.; Suri, N.] Florida Inst Human & Machine Cognit, Pensacola, FL 32502 USA. [Suri, N.] US Army, Res Lab, Adelphi, MD USA. [Boner, K.; Watson, S.] Space & Naval Warfare Syst Command, San Diego, CA USA. RP Benincasa, G (reprint author), Florida Inst Human & Machine Cognit, Pensacola, FL 32502 USA. FU Office of Naval Research [N00014- 09- 1- 0012]; U. S. Army Research Laboratory [W911NF- 11- 2- 0095] FX This work is supported by the Office of Naval Research under grant N00014- 09- 1- 0012 and the U. S. Army Research Laboratory under cooperative agreement W911NF- 11- 2- 0095. NR 17 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 7 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900181 ER PT S AU Bevec, A Bothner, P Chan, P Chike, IN Masciulli, M Markowski, M Still, GW AF Bevec, Andrej Bothner, Peter Chan, Philip Chike, Ikechi Nigel Masciulli, Michael Markowski, Michael Still, G. Welles GP IEEE TI Modeling Mobile Network Connectivity in the Presence of Jamming SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Network connectivity; model and simulation; analysis; physical layer AB The Network Connectivity Analysis Model (NCAM) is a general purpose radio frequency (RF) event-based simulator that addresses the physical layer of the International Organization for Standards (IOS) Open System Interconnect (OR) 7-layer model for wireless communication systems. With a modular design hierarchically organized to emulate an actual physical test setup, NCAM provides the U.S. Army with an extremely flexible modeling and simulation capability that could predict the impact of RF interference on mobile tactical communication networks. NCAM can simulate any number of radios or jammers in ground-based platforms. This paper describes the algorithms of each module in the model and the capabilities and features of its event-based simulation that supports dynamic state changes such as antenna swap, antenna height adjustment, radio on/off, etc. It can also pause, save, and resume simulation at a later time, for classified runs. Verified and validated by the Communication-Electronics Research, Development and Engineering Center (CERDEC), NCAM has been used to support tactical communication networks analysis. C1 [Bevec, Andrej; Bothner, Peter; Chan, Philip; Chike, Ikechi Nigel; Masciulli, Michael; Markowski, Michael; Still, G. Welles] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Bevec, A (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM ikechi.n.chike.civ@mail.mil NR 9 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0 J9 IEEE MILIT COMMUN C PY 2012 PG 4 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900317 ER PT S AU Boksiner, J Posherstnik, Y McDonald, H Arkoudas, K Chadha, R Chiang, CJ Mody, A Sherman, M AF Boksiner, Jeffrey Posherstnik, Yuriy McDonald, Howard Arkoudas, Konstantine Chadha, Ritu Chiang, C. Jason Mody, Apurva Sherman, Matthew GP IEEE TI Policy-Based Spectrum Management Architecture SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE policy-based spectrum management; dynamic spectrum access; DSA; policy based radios; digital spectrum policy AB The Department of Defense (DoD) is developing policy-based spectrum management (PBSM) concepts, architectures, and capabilities to improve DoD's use of the electromagnetic spectrum, particularly in the area of edge networking. This use of PBSM is a paradigm shift in the way DoD will manage the use of the electromagnetic spectrum in support of Dynamic Spectrum Access (DSA) enabled Policy Based Radios (PBRs). The multifaceted implications of PBSM need to be understood so that required changes to spectrum-related business processes (and the data and automated capabilities used within these processes) can be identified and coordinated with stakeholders. A major element of PBSM is the generation, distribution, and consumption of Digital Spectrum Policy (DSP) by DSA-enabled PBRs. The US Army Communications Electronics Research Development Engineering Center (CERDEC) is developing a broad set of DSA/PBSM-related capabilities including tools to generate DSP. The Defense Information Systems Agency Defense Spectrum Organization (DSO) is developing enterprise solutions for DSA/PBSM. CERDEC and DSO collaborated with BAE Systems and Applied Communication Sciences on the development of an end-to-end PBSM architecture called DSA Policy Management Architecture (DPMA). This paper presents a summary of the architecture development. C1 [Boksiner, Jeffrey; Posherstnik, Yuriy] US Army, CERDEC, Aberdeen, MD USA. [McDonald, Howard] Def Spectrum Org, DISA, Annapolis, MD USA. [Arkoudas, Konstantine; Chadha, Ritu; Chiang, C. Jason] Knowledge Based Syst, Appl Commun Sci, Piscataway, NJ USA. [Mody, Apurva; Sherman, Matthew] CCS Technol Solut, Elect Syst, Farnborough, England. RP Boksiner, J (reprint author), US Army, CERDEC, Aberdeen, MD USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900160 ER PT S AU Chow, E Vatan, F Paloulian, G Frisbie, S Srostlik, Z Kalomiris, V Apgar, D AF Chow, Edward Vatan, Farrokh Paloulian, George Frisbie, Steve Srostlik, Zuzana Kalomiris, Vasilios Apgar, Daniel GP IEEE TI Dynamic Communication Resource Negotiations SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Policy-Based Management; Policy Negotiation; Network Management AB Today's advanced network management systems can automate many aspects of the tactical networking operations within a military domain. However, automation of joint and coalition tactical networking across multiple domains remains challenging. Due to potentially conflicting goals and priorities, human agreement is often required before implementation into the network operations. This is further complicated by incompatible network management systems and security policies, rendering it difficult to implement automatic network management, thus requiring manual human intervention to the communication protocols used at various network routers and endpoints. This process of manual human intervention is tedious, error-prone, and slow. In order to facilitate a better solution, we are pursuing a technology which makes network management automated, reliable, and fast. Automating the negotiation of the common network communication parameters between different parties is the subject of this paper. We present the technology that enables inter-force dynamic communication resource negotiations to enable ad-hoc inter-operation in the field between force domains, without pre-planning. It also will enable a dynamic response to changing conditions within the area of operations. Our solution enables the rapid blending of intra-domain policies so that the forces involved are able to inter-operate effectively without overwhelming each other's networks with in-appropriate or un-warranted traffic. It will evaluate the policy rules and configuration data for each of the domains, then generate a compatible inter-domain policy and configuration that will update the gateway systems between the two domains. C1 [Chow, Edward; Vatan, Farrokh; Paloulian, George] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA. [Frisbie, Steve; Srostlik, Zuzana] SPAWAR Syst Ctr Pacific, San Diego, CA USA. [Kalomiris, Vasilios; Apgar, Daniel] US Army, CERDEC S& TCD, Aberdeen Proving Ground, MD USA. RP Chow, E (reprint author), CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900212 ER PT S AU Foresta, S Hoffmann, R Coryell, L Pinto, R AF Foresta, Saul Hoffmann, Rich Coryell, Louis Pinto, Robert GP IEEE TI Low Cost MEMS Based INS for Land-Based Military SATCOM OTM SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc AB To minimize satellite communications interference, Ground-based SATCOM terminals operating over Military X-band and Ka-band geosynchronous satellites must adhere to MIL-STD requirements for downlink pointing loss and off-axis effective isotropic radiated power (EIRP). Similarly, vehicle mounted earth stations (VMES) must adhere to strict FCC requirements on antenna pointing and Power Spectral Density (PSD) to avoid adjacent satellite interference when using commercial Ku-band geosynchronous satellites. Ground-based SATCOM on-the-move (OTM) terminals use varied tracking approaches to meet military and commercial requirements. In particular, systems that use an open-loop tracking solution typically require an Inertial Navigation System (INS). New generations of INS that use Micro Electrical-mechanical System (MEMS) inertial sensors can meet system performance requirements with cost reductions of 60% to 90%. C1 [Foresta, Saul; Hoffmann, Rich] USA, CERDEC S&TCD, Satellite Commun Syst Div, Aberdeen Proving Ground, MD USA. [Coryell, Louis] Nexagen Networks, Aberdeen, MD USA. [Pinto, Robert] Enpoint LLC, Lincoln, NE USA. RP Foresta, S (reprint author), USA, CERDEC S&TCD, Satellite Commun Syst Div, Aberdeen Proving Ground, MD USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900044 ER PT S AU Ge, LQ Zhang, DF Hardy, R Liu, H Yu, W Reschly, R AF Ge, Linqiang Zhang, Difan Hardy, Rommie Liu, Hui Yu, Wei Reschly, Robert GP IEEE TI On Effective Sampling Techniques for Host-based Intrusion Detection in MANET SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc ID AD HOC; SECURITY; NETWORKS AB Tactical Mobile Ad Hoc Network (MANET) demands a robust, diverse, and resilient protected communication and computing environment enabling network-centric operation with minimal downtime. Nevertheless, the nature of MANET causes security risks because mobile nodes are deployed in the open field and wireless communication makes the information accessible by anyone. Conducting cyber attack monitoring and detection in a tactical MANET becomes challenging because of limited resources and its infrastructureless network environment. To address these issue, we first study the host-based detection architecture to monitor and detect cyber attacks and then develop sampling techniques to balance the tradeoff between detection accuracy and bandwidth overhead. We also investigate the impact of host-based attack detection on MANET. C1 [Ge, Linqiang; Zhang, Difan; Liu, Hui; Yu, Wei] Towson Univ, Towson, MD 21252 USA. [Hardy, Rommie; Reschly, Robert] US Army, Res Lab, Adelphi, MD USA. RP Ge, LQ (reprint author), Towson Univ, Towson, MD 21252 USA. EM lge2@students.towson.edu; cheungtifan@gmail.com; rommie.l.hardy.civ@mail.mil; hliu3@students.towson.edu; wyu@towson.edu; robert.j.reschly.civ@mail.mil FU US Army Research Laboratory (ARL) [W911NF-11-1-0193] FX This work was also supported in part by US Army Research Laboratory (ARL) under grant W911NF-11-1-0193. Any opinions, findings and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the funding agencies. NR 12 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900046 ER PT S AU Gonzalez, L Tracey, M Lui, W Greel, RE Aghinii, V AF Gonzalez, Lino Tracey, Mike Lui, Wendy Greel, Richard E., Jr. Aghinii, Vasile GP IEEE TI How to Evaluate SOTM Antennas, Modems, and Architectures SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc AB The two key components that make up a "Satellite on the Move" (SOTM) terminal are the antennal and the modem. SOTM terminals can be combined to form a mobile network managed by at least one controller, typically a stationary terminal with a large aperture antenna. SOTM networks operating in the traditional commercial satellite Ku-band (14-14.5 GHz uplink) have very unique operating constraints that must be considered before acquiring and operating such a system. These SOTM operating constraints must be analyzed to determine capability and performance: 1. Regional EIRP Spectral Density (ESD) limits 2. Antenna pointing accuracy and allowable maximum transmit ESD 3. Satellite transponder performance 4. Modem/Link bit error rate (BER) 5. SOTM and Controller earth terminal performance This paper will address these system constraints in developing a concept of "Available" vs. "Achievable" operating modes of a SOTM system. The SOTM terminal theoretical "Achievable" operating mode; measured in terms of data rate (bps) and spectral efficiency (bps/Hz) is determined by its EIRP, maximum allowable transmit ESD and modem's operating E-b/N-0. The practical SOTM operating modes are established by EIRP, ESD, and the "Available" waveforms provided by the modem. Through equations, analysis, and examples; this paper will show that the best performing SOTM system, in terms of throughput, spectral efficiencies, connectivity, and having the greatest worldwide flexibility, will be a system that matches the achievable modes to its available operating modes as closely as possible. This paper will also cover "Link Availability" and "Link Margin" that are traditionally used to address weather/channel impairment and their overall impact to SOTM network throughput as well as introducing a practical mitigation technique. The final part of this paper will show that direct peer-to-peer (PtP) SOTM connectivity, herein simply referred to as PtP-SOTM, does not always have the lowest latency for data transfers. Lower latency can be achieved through the use of a large aperture antenna serving as a data relay between two SOTM nodes. SOTM architectures can be developed to trade data rate (DR), link spectral efficiency and data transfer delay (DTD). C1 [Gonzalez, Lino; Tracey, Mike; Lui, Wendy] LinQuest Corp, Orange, CA 92868 USA. [Greel, Richard E., Jr.; Aghinii, Vasile] US Army, PM WIN T, Aberdeen Proving Ground, MD USA. RP Gonzalez, L (reprint author), LinQuest Corp, Orange, CA 92868 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900030 ER PT S AU Harang, R Guarino, P AF Harang, Richard Guarino, Peter GP IEEE TI Clustering of Snort Alerts to Identify Patterns and Reduce Analyst Workload SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Computer security; Information security; Intrusion detection ID INTRUSION; FRAMEWORK AB Pattern-matching intrusion detection system (IDS) tools such as Snort are known to generate an extremely large number of alerts. To address this problem, we present a greedy aggregation algorithm that efficiently reduces multiple alerts by grouping the raw output of IDS tools into 'meta-alerts' that contain common information. In contrast to the current thrust of alert aggregation efforts, our approach does not require developing elaborate semantic structures for capturing information, nor creating and maintaining an external database containing information on attack vectors, network topologies, and cause-and-effect relationships. We apply our method to 30 days of Snort alerts, grouped by hour, and observe that we can reduce the number of analyst-visible Snort alerts by up to 99.5%, with an average reduction of approximately 83.2%. C1 [Harang, Richard] USA, ICF Int Behalf Network Secur Branch, Res Lab, Adelphi, MD 20783 USA. [Guarino, Peter] US Army, Res Lab, Adelphi, MD USA. RP Harang, R (reprint author), USA, ICF Int Behalf Network Secur Branch, Res Lab, Adelphi, MD 20783 USA. EM Richard.e.harang.ctr@mail.mil; peter.t.guarino.civ@mail.mil FU U. S. Army Research Labs [W911QX- 07- F- 0023] FX This research was sponsored by the U. S. Army Research Labs, and was partially accomplished under Contract Number W911QX- 07- F- 0023. The views and conclusions contained in this document are those of the authors, and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes, notwithstanding any copyright notation hereon. NR 17 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900217 ER PT S AU Lenzi, R Suri, N Uszok, A Hanna, J Milligan, J AF Lenzi, Rita Suri, Niranjan Uszok, Andrzej Hanna, James Milligan, James GP IEEE TI Supporting Information Management and Information Superiority via Federation Services SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Information Management; Coalition Operations; Interoperability; Network-centric systems and technologies; System of systems AB Network-centric warfare is often credited for the superior warfighting capabilities of the United States. One of the fundamental requirements for network-centric warfare is the timely exchange of information critical to mission success. The Phoenix Information Management Services (IMS) have been developed to address this all-important requirement. This paper describes a set of federation services that extend the Phoenix IMS to span multiple enclaves or domains of information management. Federation services interconnect multiple instances of Phoenix and support controlled information exchange across enclaves. Federation services, coupled with the core Phoenix information management services, are a force multiplier, allowing information to be shared across not just one, but any number of domains and information spaces. This in turn promotes shared situational awareness, unity of command, and synchronized operations across a variety of missions. C1 [Lenzi, Rita; Suri, Niranjan; Uszok, Andrzej] IHMC, Pensacola, FL 32502 USA. [Suri, Niranjan] US Army, Res Lab, Adelphi, MD USA. [Hanna, James; Milligan, James] US Air Force, Res Lab, Rome, NY USA. RP Lenzi, R (reprint author), IHMC, Pensacola, FL 32502 USA. FU U. S. Air Force Research Laboratory under Cooperative Agreement [FA8750-02-2-0174] FX This project was sponsored in part by the U. S. Air Force Research Laboratory under Cooperative Agreement FA8750-02-2-0174. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900278 ER PT S AU Morelli, A Kohler, R Stefanelli, C Suri, N Tortonesi, M AF Morelli, Alessandro Kohler, Ralph Stefanelli, Cesare Suri, Niranjan Tortonesi, Mauro GP IEEE TI Supporting COTS Applications in Tactical Edge Networks SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE SOA; Tactical Edge Networks; Network Proxies; Legacy Application Support AB Military applications are relying more and more on Commercial Off-The-Shelf (COTS) hardware and software to build their information infrastructure. However, many COTS applications have been designed for wired infrastructure networks, where bandwidth and latency are not a problem, and exhibit severe performance problems when deployed in Tactical Edge Networks. To address the issues that traditional transport protocols, such as TCP, exhibit in this environment, researchers proposed several transport protocol solutions specifically developed for Tactical Edge Networks. However, these solutions require modifications to the applications in order to be adopted. This paper presents the Agile Computing Middleware (ACM) Net Proxy: a proxy-based approach to support the deployment of COTS applications on Tactical Edge Networks. Net Proxy transparently intercepts the applications' TCP and UDP traffic and conveys it over Mockets-based connections, while also providing other useful features such as stream compression. We tested Net Proxy in an emulated environment and the results demonstrate that, besides enabling the deployment of COTS applications, Net Proxy is also capable of improving their performance. C1 [Morelli, Alessandro; Suri, Niranjan] Florida Inst Human & Machine Cognit IHMC, Pensacola, FL 32502 USA. [Morelli, Alessandro; Stefanelli, Cesare; Tortonesi, Mauro] Univ Ferrara, Dept Engn, Ferrara, Italy. [Kohler, Ralph; Suri, Niranjan] US Air Force, Res Lab, Rome, NY USA. US Army, Res Lab, Adelphi, MD USA. RP Morelli, A (reprint author), Florida Inst Human & Machine Cognit IHMC, Pensacola, FL 32502 USA. FU U. S. Air Force Research Laboratory [FA8750- 11- 2- 0095]; Office of Naval Research / U. S. Navy Space and Naval Warfare Systems Command (SPAWAR) [N66001- 11- C- 0045] FX This effort has also been funded in part by the U. S. Air Force Research Laboratory under cooperative agreement FA8750- 11- 2- 0095 and by the Office of Naval Research / U. S. Navy Space and Naval Warfare Systems Command (SPAWAR) under contract N66001- 11- C- 0045. NR 8 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 7 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900202 ER PT S AU Newman, S Schindler, J Shah, J Tinta, S Koehler, B Nilsen, R Sass, P AF Newman, Scott Schindler, Jeffrey Shah, Jiral Tinta, Sandra Koehler, Ben Nilsen, Ryan Sass, Paul GP IEEE TI Laboratory Evaluation of Military Radios and Network Architectures SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE networks; routing; performance; benchmarking; testbed; instrumentation; military; architecture; NIE AB As the ARMY prepares to deploy modern tactical networks in theater [1], there is an increasing need to ensure that radio systems will perform up to expectations before integrating them into emerging Army Capability Sets for Brigade tactical networks. Evaluating these radio systems before field deployments in a controlled laboratory setting provides a critical opportunity to establish baseline performance levels, as well as to identify and resolve design flaws and engineering bugs, long before they are encountered in the field. This paper discusses the role of the CERDEC S&TCD Radio Evaluation and Analysis Laboratory (REAL)(1) in evaluating military radio networks, not only as black-box systems, but also as part of a larger tactical network consisting of a mix of radio systems. This testing has already become an important element of the Army's Agile Process, and has demonstrated its value many times over in preparing new technologies for operational experimentation in the Army's Network Integration Evaluations (NIE) taking place at Ft Bliss, TX. C1 [Newman, Scott; Schindler, Jeffrey; Shah, Jiral; Tinta, Sandra] USA, CERDEC S& TCD, Washington, DC 20597 USA. [Koehler, Ben; Nilsen, Ryan; Sass, Paul] Mitre Corp, Mclean, VA USA. RP Newman, S (reprint author), USA, CERDEC S& TCD, Washington, DC 20597 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 8 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900103 ER PT S AU Rucker, G Cole, RG Cansever, D Mishra, A AF Rucker, G. Cole, R. G. Cansever, D. Mishra, A. GP IEEE TI Games Applied to Jam Resistant DSA Radios SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc AB In this paper, we apply Game Theory to the exploration into the development of Medium Access Protocols (MACs) for Dynamic Spectrum Access (DSA) software-define Secondary Radios (SRs) in the presence of Adversarial Jammers (AJs). We develop the Static Game representation of a hierarchical game involving the Primary Users (PUs) and the SRs and AJs. We then define a Dynamic, Repetitive Game to test the effectiveness of different SR and AJ agent strategies. These strategies are defined in terms of how aggressive the agents modify their future play based upon observations related to previous play outcomes. The observations are defined in the context of incomplete information, as it is not likely that a radio transceiver is capable of discerning all possible plays of competitors across all channels while also potentially transmitting on a given channel. We develop the Agent-Based Simulation (ABS) to investigate and analyze various versions of these games and agent strategies. We report on the results of the ABS investigations and our mathematical analysis. C1 [Rucker, G.; Cole, R. G.] USA, CERDEC STCD, 6010 Frankford St, Aberdeen Proving Ground, MD USA. [Cansever, D.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 21218 USA. [Mishra, A.] Johns Hopkins Univ, Dept Comp Sci, Baltimore, MD 21218 USA. RP Rucker, G (reprint author), USA, CERDEC STCD, 6010 Frankford St, Aberdeen Proving Ground, MD USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900074 ER PT S AU Serban, C Chadha, R Chiang, CJ Ge, F Gottlieb, Y Sapello, A Sinkar, K Moeltner, K AF Serban, C. Chadha, R. Chiang, C. J. Ge, F. Gottlieb, Y. Sapello, A. Sinkar, K. Moeltner, Kimberly GP IEEE TI A GNU-Based Packet Radio for Network Management Field Testing SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE GNU Radio; USRP; C4ISR; military environment; Network Management; Software Defined Radios AB Software Defined Radios advanced in the recent years to become the platform of choice for new military and emergency response applications, enabling such functionality as single hardware-multiple waveforms, agile spectrum reuse, and cross layer reconfiguration and optimization. Yet, the choice of platforms available for experimenting new adaptation strategies and re-configuration capabilities is severely limited due to proprietary and canned implementations and architectures. GNU Radio represents an open source radio platform operating on a general purpose processor (GPP,) capable of offering an unprecedented level of re-configurability using common and accessible programming languages and paradigms. As such, it represents an attractive and cost effective platform for experimenting with reconfigurable radio technologies. Yet, GNU Radio had been used so far mainly for experimenting with physical layer algorithms, making it less suitable for data packet radio and networking applications. This paper describes our effort to augment the GNU radio to transform it into a practical platform for communication in tactical ad-hoc networks, while maintaining its dynamic re-configurability capabilities. The results of this effort enabled us to create a deployable network capable of supporting the development and testing of TITAN NM, an integrated network management system with autonomous re-configuration capabilities, and its successful evaluation in C4ISR OTM 2012. C1 [Serban, C.; Chadha, R.; Chiang, C. J.; Ge, F.; Gottlieb, Y.; Sapello, A.; Sinkar, K.] Appl Commun Sci, Piscataway, NJ 08854 USA. [Moeltner, Kimberly] US Army Commun Elect Res, Dev & Engn Ctr CERDEC, Aberdeen Proving Ground, MD 21005 USA. RP Serban, C (reprint author), Appl Commun Sci, Piscataway, NJ 08854 USA. FU U.S Army Communications Electronics Research and Development Engineering Center (CERDEC) [W15P70-08-C-P213] FX The work reported in this document/presentation was performed in connection with contrat number W15P70-08-C-P213 with the U.S Army Communications Electronics Research and Development Engineering Center (CERDEC). NR 10 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900142 ER PT S AU Serban, C Chadha, R Chiang, CJ Ge, F Ghosh, A Gottlieb, Y Kaplan, M Kurachik, K Levin, G Lin, Y Poylisher, A Sapello, A Sultan, F Vashist, A Wolberg, M Moeltner, K AF Serban, C. Chadha, R. Chiang, C. J. Ge, F. Ghosh, A. Gottlieb, Y. Kaplan, M. Kurachik, K. Levin, G. Lin, Y. Poylisher, A. Sapello, A. Sultan, F. Vashist, A. Wolberg, M. Moeltner, Kimberly GP IEEE TI TITAN: Integrated Network Management in Tactical Mobile Ad Hoc Networks SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Mission-Driven Network Management; Fault Diagnosis; Remediation; Policies; Adaptive Middleware AB Network management represents one of the most challenging activities in tactical mobile ad hoc networks due to the need for rapid planning and configuration to support a given mission, in the face of large variability in wireless network performance and unpredictable conditions. Traditionally, independent tools, such as network planning and configuration, fault and performance management, and middleware have been designed to provide comprehensive network management capabilities. However, the lack of any integration between these tools often results in sub-optimal or conflicting network actions, conducting to inadequate network performance. More importantly, state of the art network management tools do not incorporate the mission intent into autonomous network management activities. This paper describes the TITAN (Tactical Information Technologies for Assured Networks) NM (Network Manager), an integrated network management tool that orchestrates and coordinates its actions such that network planning, configuration, fault response and performance adaptation take place seamlessly and coherently, on the basis of the mission intent. This ensures optimized network operations that achieve the intent of the mission. We present performance evaluation results for the TITAN NM in field experiments performed during C4ISR 2011 On-The-Move exercises at Fort Dix, NJ. C1 [Serban, C.; Chadha, R.; Chiang, C. J.; Ge, F.; Ghosh, A.; Gottlieb, Y.; Kaplan, M.; Kurachik, K.; Levin, G.; Lin, Y.; Poylisher, A.; Sapello, A.; Sultan, F.; Vashist, A.; Wolberg, M.] Appl Commun Sci, Piscataway, NJ 08854 USA. [Moeltner, Kimberly] US Army, Commun Elect Res, Dev & Engn Ctr CERDEC, Aberdeen Proving Ground, MD 21005 USA. RP Serban, C (reprint author), Appl Commun Sci, Piscataway, NJ 08854 USA. FU U.S Army Communications Electronics Research and Development Engineering Center (CERDEC) [W15P70-08-C-P213] FX The work reported in this document/presentation was performed in connection with contrat number W15P70-08-C-P213 with the U.S Army Communications Electronics Research and Development Engineering Center (CERDEC). NR 8 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900141 ER PT S AU Tauil, M Kant, L McAuley, A Graff, C Patel, M AF Tauil, M. Kant, L. McAuley, A. Graff, C. Patel, M. GP IEEE TI Capacity Estimation and Waveform Assignment in Military Networks SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Transport Capacity; Throughput Capacity; Waveform Assignmnet; Military Wireless Networks; Network Planning AB Military networks are required to provide continued connectivity and capacity thus providing a means to transport a diverse set of applications ranging from short mission critical messages to constant video surveillance. However, the environments that military networks have to function are often not benign and are generally fraught with bandwidth/capacity limitations. It is however imperative for military networks to be able to continue transporting key applications despite severe capacity fluctuations. The above in turn underscores the necessity for efficient capacity estimation techniques that can be used by network planners & designers when they deploy networks. While wireless network capacity estimation is a challenging problem in itself, the heterogeneous, multi-tier networks envisioned for use by the military, combined with the unpredictable changes (caused by both natural fluctuations, and/or by malicious jamming) to the underlying network, make the problem of capacity estimation for military networks extremely hard. In this paper we present a systematic approach to estimating capacity for Military mobile ad hoc networks, and also present the power of using capacity estimation techniques to assist with the problem of waveform assignment to subnets in a Military network. C1 [Tauil, M.; Kant, L.; McAuley, A.] Appl Commun Sci Inc, Piscataway, NJ 08854 USA. [Graff, C.; Patel, M.] US Army, CERDEC, Aberdeen, MD USA. RP Tauil, M (reprint author), Appl Commun Sci Inc, Piscataway, NJ 08854 USA. EM mtauil@appcomsci.com NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900306 ER PT S AU Torrieri, D Valenti, MC AF Torrieri, Don Valenti, Matthew C. GP IEEE TI Guard Zones and the Near-Far Problem in DS-CDMA Ad Hoc Networks SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc ID WIRELESS NETWORKS; INTERFERENCE AB The central issue in direct-sequence code-division multiple-access (DS-CDMA) ad hoc networks is the prevention of a near-far problem. This paper considers two types of guard zones that may be used to control the near-far problem: a fundamental exclusion zone and an additional CSMA guard zone that may be established by the carrier-sense multiple-access (CSMA) protocol. In the exclusion zone, no mobiles are physically present, modeling the minimum physical separation among mobiles that is always present in actual networks. Potentially interfering mobiles beyond a transmitting mobile's exclusion zone, but within its CSMA guard zone, are deactivated by the protocol. This paper provides an analysis of DS-CSMA networks with either or both types of guard zones. A network of finite extent with a finite number of mobiles is modeled as a uniform clustering process. The analysis uses a closed-form expression for the outage probability in the presence of Nakagami fading, conditioned on the network geometry. By using the analysis developed in this paper, the tradeoffs between exclusion zones and CSMA guard zones are explored for DS-CDMA and unspread networks. C1 [Torrieri, Don] USA, Res Lab, Adelphi, MD USA. [Valenti, Matthew C.] West Virginia Univ, Morgantown, WV USA. RP Torrieri, D (reprint author), USA, Res Lab, Adelphi, MD USA. FU National Science Foundation [CNS-0750821]; United States Army Research Laboratory [W911NF-10-0109] FX M.C. Valenti's contribution was sponsored by the National Science Foundation under Award No. CNS-0750821 and by the United States Army Research Laboratory under Contract W911NF-10-0109. NR 15 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900039 ER PT S AU Valenti, MC Torrieri, D Talarico, S AF Valenti, Matthew C. Torrieri, Don Talarico, Salvatore GP IEEE TI Optimization of a Finite Frequency-Hopping Ad Hoc Network in Nakagami Fading SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc ID TRANSMISSION CAPACITY; WIRELESS NETWORKS; INTERFERENCE AB This paper considers the analysis and optimization of a frequency-hopping ad hoc network with a finite number of mobiles and finite spatial extent. The mobiles communicate using coded continuous-phase frequency-shift keying (CPFSK) modulation. The performance of the system is a function of the number of hopping channels, the rate of the error-correction code, and the modulation index used by the CPFSK modulation. For a given channel model and density of mobiles, these parameters are jointly optimized by maximizing the (modulation-constrained) transmission capacity, which is a measure of the spatial spectral efficiency of the system. The transmission capacity of the finite network is found by using a recent expression for the spatially averaged outage probability in the presence of Nakagami fading, which is found in closed form in the absence of shadowing and can be solved using numerical integration in the presence of shadowing. C1 [Valenti, Matthew C.; Talarico, Salvatore] West Virginia Univ, Morgantown, WV 26506 USA. [Torrieri, Don] US Army, Res Lab, Adelphi, MD USA. RP Valenti, MC (reprint author), West Virginia Univ, Morgantown, WV 26506 USA. FU National Science Foundation [CNS- 0750821]; United States Army Research Laboratory [W911NF- 10- 0109] FX The authors were sponsored by the National Science Foundation under Award No. CNS- 0750821 and by the United States Army Research Laboratory under Contract W911NF- 10- 0109. NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900214 ER PT S AU Vashist, A Chadha, R Kaplan, M Moeltner, K AF Vashist, Akshay Chadha, Ritu Kaplan, Michael Moeltner, Kimberly GP IEEE TI Detecting Communication Anomalies in Tactical Networks via Graph Learning SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE Anomaly detection, Information assurance; MANETs, Graph based anomaly detection; Empirical distribution estimation AB A widely practiced approach for detecting suspicious communication in a network is to formulate the problem as statistical anomaly detection. However, the communication patterns in mission-oriented tactical networks are highly variable and have a much richer structure than incorporated by existing anomaly detection methods. For instance, the legitimacy of a communication may depend on who sends the message to who, when and under what circumstances. Existing anomaly detection methods insensitively aggregate data losing critical contextual information about the structure of communication and as a consequence, they either fail to detect suspicious communication or produce excessive amount of false positives. We have developed an extended graph based anomaly detection method that allows us to incorporate the context and rich structure of communication in a mission-oriented tactical network to model and detect suspicious patterns. We use a vector-weighted multidigraph representation to model communication and use a given data to learn the graph, i.e., to determine the nodes, the edges, and their statistical attributes corresponding to normal communication. We then use deviations from the attributes of normal communications to detect the suspicious ones. We have applied the proposed approach to detect suspicious communication in a MANET comprising of USRP2 radios and successfully demonstrated the approach in TRL-6 demonstration of the TITAN project at Fort Dix. While our proposed approach is very general, only a part of it applies to the MANET under consideration and we used it to successfully detect various types of illegal messages, congestion, and the DDoS attack. C1 [Vashist, Akshay; Chadha, Ritu; Kaplan, Michael] Appl Commun Sci, 1 Telcordia Dr, Piscataway, NJ 08854 USA. [Moeltner, Kimberly] US Army, CERDEC, Aberdeen Proving Ground, MD 21005 USA. RP Vashist, A (reprint author), Appl Commun Sci, 1 Telcordia Dr, Piscataway, NJ 08854 USA. EM avashist@appcomsci.com; rchadha@appcomsci.com; mkaplan@appcomsci.com FU U. S. Army Communications Electronics Research and Development Engineering Center ( CERDEC) [W15P7T- 08- C- P213] FX The work reported in this document/ presentation was performed in connection with contract number W15P7T- 08- C- P213 with the U. S. Army Communications Electronics Research and Development Engineering Center ( CERDEC). The views and conclusions contained in this document are those of the authors and should not be interpreted as presenting the official policies or position, either expressed or implied, of the U. S. Army CERDEC, or the U. S. Government unless so designated by other authorized documents. Citation of manufacturer's or trade names does not constitute an official endorsement or approval of the use thereof. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 16 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900203 ER PT S AU Verma, G Swami, A Chan, K AF Verma, Gunjan Swami, Ananthram Chan, Kevin GP IEEE TI The Effect of Zealotry in the Naming Game Model of Opinion Dynamics SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc AB An individual in the process of forming or updating an opinion on any given subject is heavily influenced by the opinions expressed by others in his/her social network. However, not all individuals are flexible or open-minded; some are zealots, proselytizing an opinion in hopes of convincing others, while themselves completely immune to influence. Zealotry is a common phenomenon surrounding opinions involving significant personal investment, such as political or religious affiliation. In this work, we study the effect of zealotry in the context of binary opinion dynamics (denoted as opinions A and B, such as for/against increasing taxes). We derive several key results as a function of the zealot fractions backing each of the two opinions, including the number and nature of steady state solutions. We present analytically-grounded answers to questions such as: Does the opinion with larger zealot backing always win a majority of the non-zealot population, or are there conditions under which the opinion with smaller zealot backing can win? We extend our analysis with simulations to finite population and networks with finite connectivity. C1 [Verma, Gunjan; Swami, Ananthram; Chan, Kevin] USA, Res Lab, Adelphi, MD 20783 USA. RP Verma, G (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM gunjan.verma@us.army.mil; ananthram.swami@us.army.mil; kevin.s.chan@us.army.mil NR 20 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900237 ER PT S AU Younis, O Shallcross, D Kant, L Young, K Graff, C Patel, M AF Younis, Ossama Shallcross, David Kant, Latha Young, Kenneth Graff, Charles Patel, Mitesh GP IEEE TI TDMA Scheduling and Channel Assignment for Cognitive Tactical Networks SO 2012 IEEE MILITARY COMMUNICATIONS CONFERENCE (MILCOM 2012) SE IEEE Military Communications Conference LA English DT Proceedings Paper CT IEEE Military Communications Conference (MILCOM) CY OCT 29-NOV 01, 2012 CL Orlando, FL SP IEEE, AFCEA Int, IEEE Commun Soc DE cognitive networks; MANET design; TDMA scheduling; channel assignment; cross-layer optimization; military applications ID OPPORTUNISTIC SPECTRUM ACCESS AB Shortage of spectrum constrains military applications that need to support different classes of traffic. In this work, we study efficient utilization of limited spectrum and propose joint time division multiple access (TDMA) MAC scheduling and channel assignment. First, we formulate the problem as a linear program and propose a centralized algorithm that utilizes the concept of "independent link sets" for scheduling slots and allocating channels. Compared to previous work, our approach supports partial flow loss and allows prioritization of traffic flows. Next, we propose extensions to the distributed USAP MAC protocol (widely used in military applications) to jointly assign TDMA slots and channels to links. Our extensions allow USAP to minimize either slots or channels used in the schedule; a function that is needed for dynamic behavior of future SDR/cognitive radios. We implement our scheduling algorithms in the context of a network design tool (NEDAT) and evaluate their performance using realistic mission scenarios. C1 [Younis, Ossama; Shallcross, David; Kant, Latha; Young, Kenneth] Appl Commun Sci ACS Inc, Piscataway, NJ 08854 USA. [Patel, Mitesh] US Army, CERDEC, Aberdeen, MD USA. [Graff, Charles] US Army, CERDEC, Ft Monmouth, NJ USA. RP Younis, O (reprint author), Appl Commun Sci ACS Inc, Piscataway, NJ 08854 USA. EM oyounis@appcomsci.com; dshallcross@appcomsci.com; lkant@appcomsci.com; kcy@appcomsci.com; Charles.graff@us.army.cerdec; mitesh.patel@us.army.cerdec FU U.S. Army CERDEC [DAAD-10-01-C-0062] FX This work was sponsored by U.S. Army CERDEC under contract DAAD-10-01-C-0062. The authors thank the entire project team of C- NEDAT at ACS and CERDEC for their diligence in designing and implementing C-NEDAT, and for their insightful feedback. NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-7578 BN 978-1-4673-1729-0; 978-1-4673-1730-6 J9 IEEE MILIT COMMUN C PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEY60 UT WOS:000318702900106 ER PT J AU Sabia, JJ Rees, DI AF Sabia, Joseph J. Rees, Daniel I. TI Does the number of sex partners affect educational attainment? Evidence from female respondents to the Add Health SO JOURNAL OF POPULATION ECONOMICS LA English DT Article DE Adolescent sex; Educational attainment; Abstinence ID HIGH-SCHOOL COMPLETION; US ADOLESCENT GIRLS; TEENAGE CHILDBEARING; NATURAL EXPERIMENT; DEPRESSIVE SYMPTOMS; SECULAR TREND; LABOR-MARKET; YOUNG-WOMEN; SELF-ESTEEM; AGE AB We use data on young women from the National Longitudinal Study of Adolescent Health to explore the relationship between number of sex partners and educational attainment. Using the average physical development of male schoolmates to generate plausibly exogenous variation in number of sex partners, instrumental variables estimates suggest that number of sex partners is negatively related to educational attainment. This result is consistent with the argument that romantic involvements are time consuming and can impose substantial emotional costs on young women. C1 [Sabia, Joseph J.] US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. [Sabia, Joseph J.] San Diego State Univ, Dept Econ, San Diego, CA 92812 USA. [Rees, Daniel I.] Univ Colorado, Dept Econ, Denver, CO 80217 USA. RP Sabia, JJ (reprint author), US Mil Acad, Dept Social Sci, Off Econ & Manpower Anal, West Point, NY 10996 USA. EM Joe_Sabia@yahoo.com; Daniel.Rees@ucdenver.edu NR 68 TC 5 Z9 5 U1 1 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0933-1433 J9 J POPUL ECON JI J. Popul. Econ. PD JAN PY 2012 VL 25 IS 1 BP 89 EP 118 DI 10.1007/s00148-011-0354-z PG 30 WC Demography; Economics SC Demography; Business & Economics GA 865SP UT WOS:000298330900004 ER PT B AU Shakarian, P Paulo, D AF Shakarian, Paulo Paulo, Damon GP IEEE TI Large Social Networks can be Targeted for Viral Marketing with Small Seed Sets SO 2012 IEEE/ACM INTERNATIONAL CONFERENCE ON ADVANCES IN SOCIAL NETWORKS ANALYSIS AND MINING (ASONAM) LA English DT Proceedings Paper CT IEEE/ACM International Conference on Advances in Social Networks Analysis and Mining CY AUG 26-29, 2012 CL Kadir Has Univ, Istanbul, TURKEY SP ACM, IEEE, ACM Sigmod, IEEE Comp Soc (CS), Springer, TCDE, TUBiTAK, TUBiTAK BiLGEM, ACTC SMCS, IEEE Tech Comm Data Engn, Univ Calgary, Hellen Amer Univ, sbtanaliz, EX tra Foreign Trade Co Ltd, inforcept, FNSS Savunma Sistemleri A S, raccoonize, Huawei HO Kadir Has Univ DE social networks; viral marketing AB In a "tipping" model, each node in a social network, representing an individual, adopts a behavior if a certain number of his incoming neighbors previously held that property. A key problem for viral marketers is to determine an initial "seed" set in a network such that if given a property then the entire network adopts the behavior. Here we introduce a method for quickly finding seed sets that scales to very large networks. Our approach finds a set of nodes that guarantees spreading to the entire network under the tipping model. After experimentally evaluating 31 real-world networks, we found that our approach often finds such sets that are several orders of magnitude smaller than the population size. Our approach also scales well - on a Friendster social network consisting of 5.6 million nodes and 28 million edges we found a seed sets in under 3.6 hours. We also find that highly clustered local neighborhoods and dense network-wide community structure together suppress the ability of a trend to spread under the tipping model. C1 [Shakarian, Paulo] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. [Paulo, Damon] US Mil Acad, Dept Elect Engn & Comp, West Point, NY 10996 USA. RP Shakarian, P (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA. EM paulo@shakarian.net; damon.paulo@usma.edu FU Army Research Office [2GDATXR042]; Office of the Secretary of Defense [F1AF262025G001] FX We would like to thank Gaylen Wong (USMA) for his technical support. Additionally, we would like to thank (inno particular order) Albert-Laszl o Barab asi (NEU), Sameet Sreenivasan (RPI), Boleslaw Szymanski (RPI), John James (USMA), and Chris Arney (USMA) for their discussions relating to this work. Finally, we would also like to thank Megan Kearl, Javier Ivan Parra, and Reza Zafarani of ASU for their help with some of the datasets. The authors are supported under by the Army Research Office (project 2GDATXR042) and the Office of the Secretary of Defense (project F1AF262025G001). The opinions in this paper are those of the authors and do not necessarily reflect the opinions of the funders, the U.S. Military Academy, or the U.S. Army. NR 24 TC 6 Z9 6 U1 2 U2 10 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-0-7695-4799-2; 978-1-4673-2497-7 PY 2012 BP 1 EP 8 DI 10.1109/ASONAM.2012.11 PG 8 WC Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BFL86 UT WOS:000320443500001 ER PT S AU Liu, X Tang, KZ Harper, S Harper, B Steevens, JA Xu, R AF Liu, Xiong Tang, Kaizhi Harper, Stacey Harper, Bryan Steevens, Jeffery A. Xu, Roger BE Gao, J Dubitzky, W Wu, C Liebman, M Alhaij, R Ungar, L Christianson, A Hu, X TI Predictive Modeling of Nanomaterial Biological Effects SO 2012 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS (BIBMW) SE IEEE International Conference on Bioinformatics and Biomedicine Workshop-BIBMW LA English DT Proceedings Paper CT IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) CY OCT 04-07, 2012 CL Philadelphia, PA SP IEEE, IEEE Comp Soc (CS), Natl Sci Fdn (NSF), Omic Soft Corp, IEEE Comp Soc Tech Comm Bioinformat DE Nanoinformatics; nanomaterial biological effects; toxicity; modeling; data mining AB Nanomaterial environmental impact (NEI) modeling is critical for industry and policymakers to assess the unintended biological effects (e. g. mortality, malformation, growth inhibition) resulting from the application of engineered nanomaterials. The scope of NEI modeling covers nanomaterial physical, chemical and manufacturing properties, exposure and study scenarios, environmental and ecosystem responses, biological responses, and their interactions. In this paper, we introduce a data mining approach to modeling the biological effects of nanomaterials. Data mining techniques can assist analysts in developing risk assessment models for nanomaterials. Using an experimental dataset on the toxicity of nanomaterials to embryonic zebrafish, we conducted case studies on modeling the overall effect/impact of nanomaterials and the specific toxic end-points such as mortality, delayed development, and morpholigcal malformations and behavioral abnormalities. The results show that different biological effects have different modeling accuracy given the same set of algorithms and data. The results also show that the weighting scheme for different biological effects has a significant influence on modeling the overall biological effect. These results provide insights into the understanding and modeling of nanomaterial biological effects. C1 [Liu, Xiong; Tang, Kaizhi; Xu, Roger] Intelligent Automat Inc, Rockville, MD 20855 USA. [Harper, Stacey; Harper, Bryan] Oregon State Univ, Dept Environm Mol Toxicol, Corvallis, OR USA. [Harper, Stacey] Oregon State Univ, Sch Chem Biol & Environm Engn, Corvallis, OR USA. [Steevens, Jeffery A.] ERDC Environm Lab, Vicksburg, MS USA. RP Liu, X (reprint author), Intelligent Automat Inc, Rockville, MD 20855 USA. EM xliu09@gmail.com; ktang@i-a-i.com; stacey.harper@oregonstate.edu; harperb@ace.orst.edu; jeffery.a.steevens@usace.army.mil; hgxu@i-a-i.com FU U.S. Army Corps of Engineers for their support under research [W912HZ-llP-0009, W912HZ-12-C-0004]; NIEHS [ES01755201A2, ES016896- 01, P30 ES03850]; AFRL [FA865005-1-5041] FX The authors wish to thank U.S. Army Corps of Engineers for their support under research contract Nos. W912HZ-llP-0009 and W912HZ-12-C-0004; NIEHS grants ES01755201A2, ES016896- 01 and P30 ES03850; and AFRL FA865005-1-5041. NR 11 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2163-6966 BN 978-1-4673-2746-6; 978-1-4673-2745-9 J9 IEEE INT C BIO BIO W PY 2012 PG 5 WC Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Medical Informatics SC Computer Science; Mathematical & Computational Biology; Medical Informatics GA BFL42 UT WOS:000320379600150 ER PT S AU Tang, KZ Liu, X Harper, S Steevens, JA Xu, R AF Tang, Kaizhi Liu, Xiong Harper, Stacey Steevens, Jeffery A. Xu, Roger BE Gao, J Dubitzky, W Wu, C Liebman, M Alhaij, R Ungar, L Christianson, A Hu, X TI NEIMiner: A Model Driven Data Mining System for Studying Environmental Impact of Nanomaterials SO 2012 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE WORKSHOPS (BIBMW) SE IEEE International Conference on Bioinformatics and Biomedicine Workshop-BIBMW LA English DT Proceedings Paper CT IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) CY OCT 04-07, 2012 CL Philadelphia, PA SP IEEE, IEEE Comp Soc (CS), Natl Sci Fdn (NSF), Omic Soft Corp, IEEE Comp Soc Tech Comm Bioinformat DE nanomaterial environmental impact; modeling; data integration; data management; content management system AB As more engineered nanomaterials (eNM) are developed for a wide range of applications, it is crucial to minimize any unintended environmental impacts resulting from the application of eNM. To realize this vision, industry and policymakers must base risk management decisions on sound scientific information about the environmental fate of eNM, their availability to receptor organisms (e. g., uptake), and any resultant biological effects (e. g. toxicity). To address this critical need, we propose a model driven data mining system, called NEIMiner, for studying nanomaterial environmental impact (NEI). NEIMiner consists of four components: NEI modeling framework, data integration, data management and access, and model discovery and composition. The NEI modeling framework defines the scope of NEI modeling and the strategy of integrating NEI models to form a layered, comprehensive predictability. The data integration layer brings together heterogeneous data sources related to NEI via automatic web services and web scraping technologies. The data management and access layer reuses and extends a popular Content Management System (CMS), Drupal, and consists of modules that model the complex data structure for NEI related bibliography and characterization data. The model discovery and composition layer provides an advanced analysis capability for NEI data. Together, these components provide significant value to the process of aggregating and analyzing large-scale distributed NEI data. A prototype of the NEIMiner system is available at http://neiminer.i-a-i.com/, C1 [Tang, Kaizhi; Liu, Xiong; Xu, Roger] Intelligent Automat Inc, Rockville, MD 20855 USA. [Liu, Xiong] Oregon State Univ, Dept Environm Mol Toxicol, Corvallis, OR USA. [Harper, Stacey] Oregon State Univ, Sch Chem Biol & Environm Engn, Corvallis, OR USA. [Steevens, Jeffery A.] ERDC Environm Lab, Vicksburg, MS USA. RP Tang, KZ (reprint author), Intelligent Automat Inc, Rockville, MD 20855 USA. EM ktang@i-a-i.com; xliu09@gmai1.com; stacey.harper@oregonstate.edu; jeffery.a.steevens@usace.army.mil; hgxu@i-a-i.com FU U.S. Army Corps of Engineers for their support under research [W912HZ-llP-0009, W912HZ-12-C-0004]; NIEHS [ES01755201A2, ES016896-01, P30 ES03850]; AFRL [FA865005-1-5041] FX The authors wish to thank U.S. Army Corps of Engineers for their support under research contract No. W912HZ-llP-0009 and W912HZ-12-C-0004; NIEHS grants ES01755201A2, ES016896-01 and P30 ES03850; and AFRL FA865005-1-5041. NR 6 TC 0 Z9 0 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2163-6966 BN 978-1-4673-2746-6; 978-1-4673-2745-9 J9 IEEE INT C BIO BIO W PY 2012 PG 8 WC Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Medical Informatics SC Computer Science; Mathematical & Computational Biology; Medical Informatics GA BFL42 UT WOS:000320379600156 ER PT B AU Little, BJ Arnas, AO AF Little, Benjamin J. Arnas, A. Oezer GP ASME TI THERMALLY ACTIVATED PROTECTIVE SYSTEMS: MATERIAL CONSIDERATIONS FOR IMPROVED FLASH/FLAME PROTECTION SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2010, VOL 2 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 12-18, 2010 CL Vancouver, CANADA SP Amer Soc Mech Engineers AB This paper is based on an effort to increase the protection from thermal and flash/flame threats due to explosion. The relatively recent threat of Improvised Explosive Devices, IEDs, the large thermal energy associated with them, as well as the secondary fires has prompted an investigation into whether the personal protective equipment available to the individual soldier provides adequate protection from injury. This is a continuation of a previous paper that investigated the full extent of the threat posed by explosions: The research included a profile of the thermal properties of the threat, typical injuries associated with explosions, as well as several possible means of alleviating the dangers. One means that was suggested was the use of intumescent materials. These are materials that expand when exposed to heat, thus increasing the distance between the threat and the person as well as altering their thermal conductivity to make them more resistant to burn. Using this suggestion, in this paper we seek to determine the feasibility of using these materials in. a protective garment. It factors in soldier concerns of durability, comfort, et cetera but focuses mainly on the heat transfer aspects of the material. C1 [Little, Benjamin J.; Arnas, A. Oezer] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Little, BJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. EM ozer.arnas@usma.edu NR 10 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4426-7 PY 2012 BP 225 EP 232 PG 8 WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Engineering, Mechanical SC Biotechnology & Applied Microbiology; Engineering GA BFJ68 UT WOS:000320140200035 ER PT B AU Boettner, DD Crawford, BG AF Boettner, Daisie D. Crawford, Bobby G. GP ASME TI CONSISTENCY CONSIDERATIONS FOR INTEGRATED THERMODYNAMICS AND FLUID MECHANICS INSTRUCTION SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION (IMECE 2010), VOL 6 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 12-18, 2010 CL Vancouver, CANADA SP Amer Soc Mech Engineers AB As a result of mechanical engineering curriculum revision at the United States Military Academy at West Point, separate courses in thermodynamics and fluid mechanics were integrated into a two-course sequence, Thermal-fluid Systems I and II, in academic year 2005-2006. After four years of instruction using available text books from publishers, the mechanical engineering faculty developed a text tailored specifically to the integrated two-course sequence. The experience in writing a text that integrates concepts in thermodynamics and fluid mechanics highlights the need for consistency between the two disciplines. Issues identified include logical organization of topics, selection of appropriate variables, consistent use of sign convention throughout all topics, recognition of various forms of the same fundamental principle, and definition of performance parameters. This paper explores these issues and how they were addressed for integrated instruction of thermodynamics and fluid mechanics. C1 [Boettner, Daisie D.; Crawford, Bobby G.] US Mil Acad, West Point, NY 10996 USA. RP Boettner, DD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4443-4 PY 2012 BP 193 EP 198 PG 6 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BFM22 UT WOS:000320480600025 ER PT B AU Floersheim, B Johnston, J AF Floersheim, Bruce Johnston, Jonathan GP ASME TI The Conceptual Speed-Bump: Losing Potential STEM Students in the Transition from Elementary School to Middle School SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION (IMECE 2010), VOL 6 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 12-18, 2010 CL Vancouver, CANADA SP Amer Soc Mech Engineers AB Many educators in the science, technology, engineering and math (STEM) disciplines hope to improve the number of students interested in and prepared for these more difficult disciplines through innovative teaching, demonstrations and hosted camps. Research has shown that motivation is a much smaller part of the issue; student learning outcomes are much more sensitive to fundamental academic ability. Current curriculum design fails most students miserably in helping them bridge the gap from concrete learning to abstract thought and understanding in the middle school years. Thus, they are ill-prepared to engage in the more advanced learning required to pursue the STEM disciplines, a result that no amount of innovative teaching can correct. This paper will review the performance data from industrial nations at the 4th Grade and 8th Grade levels and illustrate curriculum differences between industrial countries producing higher percentages of STEM graduates. Examination of the performance effects of many variables, including number and sequencing of topics studied, time spent on homework, teacher credentials, access to technology, class size and dollars allocated per student, yields some surprising results. The problem is not as sensitive to many of these variables as one might expect. However, the variables that seem to provide promise for significant improvement from the current state of STEM education are related to topic coverage and manner of presentation. Final recommendations include reduction in the number of topics introduced in any given year with a corresponding reorganization of the curricula, to allow STEM teachers in the middle school to focus on the transitional learning that must occur to prepare for more advanced studies. C1 [Floersheim, Bruce; Johnston, Jonathan] US Mil Acad, West Point, NY 10996 USA. RP Floersheim, B (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 17 TC 0 Z9 0 U1 1 U2 7 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4443-4 PY 2012 BP 413 EP 423 PG 11 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BFM22 UT WOS:000320480600053 ER PT B AU Nassar, SA Mao, JH Yang, XJ Templeton, D AF Nassar, Sayed A. Mao, Jianghui Yang, Xianjie Templeton, Douglas BE Mertiny, P TI EFFECT OF ADHESIVES ON THE MECHANICAL BEHAVIOR OF THICK COMPOSITE JOINTS SO PROCEEDINGS OF THE ASME PRESSURE VESSELS AND PIPING CONFERENCE, VOL 3: DESIGN AND ANALYSIS LA English DT Proceedings Paper CT ASME Pressure Vessels and Piping Conference CY JUL 17-21, 2011 CL Baltimore, MD SP ASME, Pressure Vessels & Pip Div DE laminated composite; adhesive bonding; damage modeling ID LAMINATED COMPOSITES; DAMAGE DETECTION; DELAMINATION; STRESSES; MODEL AB In this paper, experimental and numprical methods are used to study the deformation and interfacial failure behavior of an adhesively-bonded thick joint made of multi-layer S2 glass/SC-15 epoxy resin composite material. The adhesive material is 3M Scotch-Weld Epoxy Adhesive DP,405 Black. Continuum damage mechanics models are used to describe the damage initiation at or near the interface and final failure process. The effect of adhesive overlap length, thickness and plasticity on the interfacial shear stress and normal stress are studied. Experimental and analytical data are used to validate the proposed damage models. C1 [Nassar, Sayed A.; Mao, Jianghui; Yang, Xianjie] Oakland Univ, Dept Mech Engn, Fastening & Joining Res Inst, Rochester, MI 48309 USA. [Templeton, Douglas] US Army, TARDEC, Warren, MI 48397 USA. RP Nassar, SA (reprint author), Oakland Univ, Dept Mech Engn, Fastening & Joining Res Inst, Rochester, MI 48309 USA. FU U.S. Government; ASME FX This work is in part a work of the U.S. Government. ASME disclaims all interest in the U.S. Government's contributions. NR 31 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4453-3 PY 2012 BP 3 EP + PG 4 WC Engineering, Mechanical SC Engineering GA BFL08 UT WOS:000320340600002 ER PT B AU Harris, JT Segall, AE Carter, R AF Harris, J. T. Segall, A. E. Carter, R. BE Mertiny, P TI DEFECT EVOLUTION IN COATED TUBES UNDER SEVERE THERMAL TRANSIENTS APPLIED TO THE ID SO PROCEEDINGS OF THE ASME PRESSURE VESSELS AND PIPING CONFERENCE, VOL 3: DESIGN AND ANALYSIS LA English DT Proceedings Paper CT ASME Pressure Vessels and Piping Conference CY JUL 17-21, 2011 CL Baltimore, MD SP ASME, Pressure Vessels & Pip Div DE Transient; Thermal-Stress and -Strain; Cylinder ID BARRIER COATINGS; DELAMINATION; SUBSTRATE; CRACKING; DAMAGE; MECHANISMS AB The effects of severe thermal-transients on coated substrates with indentation-induced, blister type defects were analyzed using finite-element methods. Both explicit and implicit approaches were used depending on the timeframe under scrutiny. For the modeling, an axisymmetric mesh and cohesive zone elements was used to assess the transient thermal - and stress-states and the propensity for fracture related damage and evolution. For all calculations (and when available), temperature dependent thermophysical and elastic properties were used during the analysis. The model also utilized uniform heating across the surface imposed via convective coefficients and a piece-wise linear pressure function. Preliminary results indicated complex interactions between the boundary conditions and their timing and the resulting propensity for damage evolution. Given the need for robust coatings, the modeling procedures developed during this study will have important ramifications for coated tube designs and the evaluation of candidate materials. C1 [Harris, J. T.; Segall, A. E.] Penn State Univ, 212 EES Bldg, University Pk, PA 16803 USA. [Carter, R.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Harris, JT (reprint author), Penn State Univ, 212 EES Bldg, University Pk, PA 16803 USA. EM jth203@psu.edu; aesegall@psu.edu; rcarter@arl.army.mil NR 21 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4453-3 PY 2012 BP 1101 EP + PG 3 WC Engineering, Mechanical SC Engineering GA BFL08 UT WOS:000320340600132 ER PT B AU Benson, M Laskowski, G Elkins, C Eaton, JK AF Benson, Michael Laskowski, Gregory Elkins, Chris Eaton, John K. GP ASME TI FILM-COOLED TRAILING EDGE MEASUREMENTS: 3D VELOCITY AND SCALAR FIELD SO PROCEEDINGS OF THE ASME TURBO EXPO 2011, VOL 5, PTS A AND B LA English DT Proceedings Paper CT ASME Turbo Expo 2011 CY JUN 06-10, 2011 CL Vancouver, CANADA SP ASME, Int Gas Turbine Inst ID GAS-TURBINE AIRFOILS; COOLING EFFECTIVENESS; CUTBACK AB Aircraft turbine blade trailing edges commonly are cooled by blowing air through pressure-side cutback slots. The surface effectiveness is governed by the rate of mixing of the coolant with the mainstream, which is typically much faster than predicted by CFD models. 3D velocity and coolant concentration fields were measured in and around a cutback slot using a simple uncambered airfoil with a realistic trailing edge cooling geometry at a Reynolds number of 110,000 based on airfoil chord length, which is lower than practical engines but still in the turbulent regime. The results were obtained using magnetic resonance imaging (MRI) techniques in a water flow apparatus. Magnetic resonance concentration (MRC) scans measured the concentration distribution with a spatial resolution of 0.5 mm(3) (compared to a slot height of 5 mm) and an uncertainty near 5%. Magnetic resonance velocimetry (MRV) was used to acquire 3D, three-component mean velocity measurements with a resolution of 1.0 mm(3). Coupled concentration and velocity measurements were used to identify flow structures contributing to the rapid mixing, including longitudinal vortices and separation bubbles. Velocity measurements at several locations were compared with an unsteady RANS model. Concentration measurements extrapolated to the surface provided film cooling effectiveness and showed that the longitudinal vortices decreased effectiveness near the lands and reduced the average film cooling effectiveness. C1 [Benson, Michael] Stanford Univ, US Mil Acad, West Point, NY USA. RP Benson, M (reprint author), Stanford Univ, US Mil Acad, West Point, NY USA. NR 20 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5465-5 PY 2012 BP 1 EP 10 PG 10 WC Engineering, Mechanical SC Engineering GA BFR71 UT WOS:000321076300001 ER PT B AU Thurman, DR El-Gabry, LA Poinsatte, PE Heidmann, JD AF Thurman, Douglas R. El-Gabry, Lamyaa A. Poinsatte, Philip E. Heidmann, James D. GP ASME TI TURBULENCE AND HEAT TRANSFER MEASUREMENTS IN AN INCLINED LARGE SCALE FILM COOLING ARRAY - PART II, TEMPERATURE AND HEAT TRANSFER MEASUREMENTS SO PROCEEDINGS OF THE ASME TURBO EXPO 2011, VOL 5, PTS A AND B LA English DT Proceedings Paper CT ASME Turbo Expo 2011 CY JUN 06-10, 2011 CL Vancouver, CANADA SP ASME, Int Gas Turbine Inst ID STREAMWISE ANGLES; CROSS-FLOW; HOLES; ROW; DOWNSTREAM; INJECTION; RATIO AB The second of a two-part paper, this study focuses on the temperature field and surface heat transfer measurements on a large-scale models of an inclined row of film cooling holes. Detailed surface and flow field measurements were taken and presented in Part I. The model consists of three holes of 1.9-cm diameter that are spaced 3 hole diameters apart and inclined 30 degrees from the surface. Additionally, another model with an anti-vortex adaptation to the film cooling holes is also tested. The coolant stream is metered and cooled to 20 degrees C below the mainstream temperature. A thermocouple is used to obtain the flow temperatures along the jet centerline and at various streamwise locations. Steady state liquid crystal thermography is used to obtain surface heat transfer coefficients. Results are obtained for blowing ratios of up to 2 in order to capture off-design conditions in which the jet is lifted. Film cooling effectiveness values of 0.4 and 0.15 were found along the centerline for blowing ratios of 1 and 2 respectively. In addition, an anti-vortex design was tested and found to have improved film effectiveness. This paper presents the detailed temperature contours showing the extent of mixing between the coolant and freestream and the local heat transfer results. C1 [Thurman, Douglas R.] US Army, Res Lab, Glenn Res Ctr, Cleveland, OH USA. RP Thurman, DR (reprint author), US Army, Res Lab, Glenn Res Ctr, Cleveland, OH USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-5465-5 PY 2012 BP 551 EP 558 PG 8 WC Engineering, Mechanical SC Engineering GA BFR71 UT WOS:000321076300049 ER PT S AU Li, L Scaglione, A Swami, A Zhao, Q AF Li, Lin Scaglione, Anna Swami, Ananthram Zhao, Qing BE Matthews, MB TI Strategic Communications in Opinion Diffusion SO 2012 CONFERENCE RECORD OF THE FORTY SIXTH ASILOMAR CONFERENCE ON SIGNALS, SYSTEMS AND COMPUTERS (ASILOMAR) SE Conference Record of the Asilomar Conference on Signals Systems and Computers LA English DT Proceedings Paper CT 46th Asilomar Conference on Signals, Systems and Computers CY NOV 04-07, 2012 CL Pacific Grove, CA SP Naval Postgraduate Sch, ATK Miss Res, IEEE Signal Proc Soc AB We propose a strategic communication model, in which social agents play a central role in determining how much effort and time they want to invest in interacting with others. The starting point for this paper is the so called bounded confidence model in which agents update their opinions only when they are like-minded (i.e., their opinion distance is smaller than a threshold). In our model, in addition to the existence of trust between interacting agents, the agents also individually determine the expected time and effort in interacting with their neighboring agents. The strategic communication thus refers to the process that allows individuals to select neighbors, with whom interaction produces a maximization of the local utility functions. Our goal is to analyze the dynamics of opinion formation under the proposed communication strategy, with a focus on understanding how and under what conditions clustering patterns emerge in opinion space. C1 [Li, Lin; Scaglione, Anna; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Li, L (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. EM llli@ucdavis.edu; ascaglione@ucdavis.edu; ananthram.swami@us.army.mil; qzhao@ucdavis.edu NR 10 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1058-6393 BN 978-1-4673-5051-8 J9 CONF REC ASILOMAR C PY 2012 BP 515 EP 519 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BFO76 UT WOS:000320768400095 ER PT B AU Rodriguez, RI Ibitayo, D Quintero, PO AF Rodriguez, Rogie I. Ibitayo, Dimeji Quintero, Pedro O. GP ASME TI HIGH TEMPERATURE DIE ATTACH BY LOW TEMPERATURE SOLID-LIQUID INTERDIFFUSION SO PROCEEDINGS OF THE ASME PACIFIC RIM TECHNICAL CONFERENCE AND EXHIBITION ON PACKAGING AND INTEGRATION OF ELECTRONIC AND PHOTONIC SYSTEMS, MEMS AND NEMS 2011, VOL 1 LA English DT Proceedings Paper CT ASME Pacific Rim Technical Conference and Exhibition on Packaging and Integration of Electronic and Photonic Systems, MEMS and NEMS CY JUL 06-08, 2011 CL Portland, OR SP ASME, Japan Soc Mech Engineers ID SEQUENTIAL ELECTROPLATING METHOD; STATE INTERFACIAL REACTIONS; ELECTROLESS NI-P; SN-3.5AG SOLDER; CU SUBSTRATE; SN; AU; RELIABILITY; METALLIZATION; JOINT AB There is a need for electromechanical devices capable of operating in high temperature environments (>200 degrees C) for a wide variety of applications. Today's wide-bandgap semiconductor based power electronics have demonstrated a potential of operating above 400 degrees C, however they are still limited by packaging. Our group has been conducting research in novel interconnect technologies to develop reliable electronic packaging for high temperature environments. Among the most promising alternative is the Au-Sn eutectic solder (80 wt.% Au - 20 wt.% Sn), which have been widely used due to its excellent mechanical and thermal properties. However, the operating temperature of this metallurgical system is still limited to similar to 250 degrees C owing to its melting temperature of 280 degrees C. Therefore, a higher temperature resistant system is much needed, but without affecting the current processing temperature of similar to 325 degrees C typically exhibited in most high temperature Pb-Free solders. This paper presents the development and characterization of a fluxless die attach soldering process based on gold enriched solid liquid inter-diffusion (SLID). A low melting point eutectic Au-Sn was deposited in the faces of two substrates, followed by the deposition of a subsequent layer of high melting point material, gold in this instance, in one of the substrates. Deposition of all materials was performed using Jet Vapor Deposition (JVD) equipment where thicknesses were controlled to achieve specific compositions in the mixture. Sandwiched coupons where isothermally processed in a vacuum reflow furnace. Scanning electron microscopy (SEM) was employed to reveal the microstructural evolution of the samples in order to study the interfacial reactions of this fluxless bonding process. EDS analysis was used to identify the intermetallic formation and to characterize the joint in an attempt to study the kinetics of this diffusion couple. Post-processed samples confirmed the inter-diffusion mechanism evidenced by the formation of sound joints between the two substrates. As expected, it was observed that the Au was dissolved into the eutectic Au-Sn as the reflow time and temperature were increased. C1 [Rodriguez, Rogie I.; Quintero, Pedro O.] Univ Puerto Rico, Mayaguez, PR USA. [Ibitayo, Dimeji] US Army Res Lab, Adelphi, MD USA. RP Rodriguez, RI (reprint author), Univ Puerto Rico, Mayaguez, PR USA. EM pedro.quintero@upr.edu FU US Army Research Laboratory [W911NF-07-D-0001]; National Science Foundation NSF [BRIGE EEC-09266268] FX The authors thank the US Army Research Laboratory (Contract W911NF-07-D-0001) and the National Science Foundation (NSF Grant: BRIGE EEC-09266268) for partial financial support for this research. The authors thank Mr. Gabriel Cruz from Hewlett Packard Caribe for his excellent support using the SEM and EDS equipment. NR 23 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4461-8 PY 2012 BP 9 EP + PG 3 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA BFJ69 UT WOS:000320140300002 ER PT J AU Zoltani, CK AF Zoltani, Csaba K. BE Gupta, RC TI Cardiovascular toxicity SO VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, 2ND EDITION LA English DT Article; Book Chapter ID LARKSPUR DELPHINIUM-BARBEYI; ACUTE MYOCARDIAL-INFARCTION; OLEANDER NERIUM-OLEANDER; PHOSPHATASE INHIBITOR; CARDIAC-ARRHYTHMIAS; GRAYANOTOXIN I; CONTRACTILE; LIVESTOCK; CATTLE; STINGS C1 USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Zoltani, CK (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. NR 86 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA BN 978-0-12-385927-3 PY 2012 BP 235 EP 245 DI 10.1016/B978-0-12-385926-6.00016-8 PG 11 WC Toxicology; Veterinary Sciences SC Toxicology; Veterinary Sciences GA BER41 UT WOS:000317854000017 ER PT B AU Larson, S Ballard, J Griggs, C Newman, JK Nestler, C AF Larson, Steven Ballard, John Griggs, Christopher Newman, J. Kent Nestler, Catherine GP ASME TI AN INNOVATIVE NON-PETROLEUM RHIZOBIUM TROPICI BIOPOLYMER SALT FOR SOIL STABILIZATION SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION - 2010, VOL 5, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 12-18, 2010 CL Vancouver, CANADA SP Amer Soc Mech Engineers DE biopolymer; EPS; vegetative cover; erosion; construction site ID EROSION CONTROL; POLYACRYLAMIDE AB Construction site soils are a significant source of sediment, and pollutants carried by sediment, to surface water runoff. Currently, silt fences/barriers, petroleum-derived polymers, and re-vegetation are the primary tools to prevent sediment loss from construction areas. Even with these methods in place, the U.S. Environmental Protection Agency estimates that 20 to 150 tons of soil per acre is lost to storm water runoff from construction sites each year. A low-cost, environmentally friendly soil amendment that reduces erosion from construction sites would improve surface water quality. An extracellular polymeric substance (EPS) is produced naturally by the symbiotic soil bacterium Rhizobium tropici. A dry, easily transportable salt of this biopolymer, when mixed with soil at low levels (0.01 to 0.5% by mass) substantially increases the soil strength for load bearing, decreases surface erosion and suspended solids in surface water runoff. Re-vegetation is also assisted by biopolymer application, since drought resistance and seed germination rates can be increased by 30% to 40% using the biopolymer. Results of mesoscale rainfall lysimeter system demonstrations of soil amendment with biopolymer documents reduced soil erosion, reduced transport of suspended solids in surface water runoff, and increased establishment success of vegetative cover under simulated drought conditions in biopolymer amended soils. C1 [Larson, Steven; Ballard, John; Griggs, Christopher] USACE ERDC, Environm Lab, Vicksburg, MS USA. RP Larson, S (reprint author), USACE ERDC, Environm Lab, Vicksburg, MS USA. NR 8 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4429-8 PY 2012 BP 1279 EP 1284 PG 6 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BFN51 UT WOS:000320625800143 ER PT B AU Littlefield, DL Walls, KC Danielson, KT Jordan, J AF Littlefield, David L. Walls, Kenneth C. Danielson, Kent T. Jordan, Joseph BE Papadakis, G TI VALIDATION OF THE KERLEY SOIL MODEL IN CTH SO PROCEEDINGS OF THE ASME PRESSURE VESSELS AND PIPING CONFERENCE (PVP-2011), VOL 4 LA English DT Proceedings Paper CT ASME Pressure Vessels and Piping Conference CY JUL 17-21, 2011 CL Baltimore, MD SP ASME, Pressure Vessels & Pip Div AB Recently Kerley has developed a soil model suitable for implementation in Eulerian hydrocodes. The model has been installed into CTH [1]. While basic features of the model suggest it may be suitable for modeling ground shock and cratering problems, it has not been extensively validated. As such, in order to provide more confidence in the use the model, a series of calculations was conducted to compare Kerley's model to the Hybrid Elastic-Plastic (HEP) model. C1 [Littlefield, David L.; Walls, Kenneth C.] Univ Alabama Birmingham, Dept Mech Engn, Birmingham, AL 35294 USA. [Danielson, Kent T.; Jordan, Joseph] Engn Res & Dev Ctr, Vicksburg, MS USA. RP Littlefield, DL (reprint author), Univ Alabama Birmingham, Dept Mech Engn, Birmingham, AL 35294 USA. FU Productivity Enhancement, Technology Transfer and Training (PETTT) Program under the High Performance Computing Modernization Program (HPCMP) FX This work was supported by the Productivity Enhancement, Technology Transfer and Training (PETTT) Program under the High Performance Computing Modernization Program (HPCMP). NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4454-0; 978-0-7918-4454-0 PY 2012 BP 467 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BFL57 UT WOS:000320410300057 ER PT J AU Silvious, J Tahmoush, D AF Silvious, Jerry Tahmoush, Dave GP IEEE TI Pattern of Life for Radar Port and River Security SO 2012 IEEE INTERNATIONAL CONFERENCE ON TECHNOLOGIES FOR HOMELAND SECURITY LA English DT Proceedings Paper CT 12th IEEE International Conference on Technologies for Homeland Security (HST) CY NOV 13-15, 2012 CL Waltham, MA SP IEEE, IEEE Biometr Council (BIO), IEEE Boston Sect, IEEE USA, Massport, L3 Commun, Global Secur Finance, Homeland Secur Jobs, Market Res Media DE Micro-Doppler; Radar AB Ground-based radar can provide inexpensive wide-area surveillance of river and port traffic for both security and emergency response. Electronically scanning the radar beam over multiple azimuthal angles rapidly provides extremely wide area coverage. A compact X-band radar was used to scan over a ninety degree sector on a river/harbor environment. An individual moving target indicator (MTI) track triggered a long-range camera, which pans and zooms to get a quality image and allows an exact identification of the mover. We demonstrate the simultaneous tracking of multiple vessels in a river environment along with the associated imagery over several days. We also evaluate the micro-Doppler signatures of different classes of small vessels, including kayaks and zodiacs, as well as pattern of life and port interactions. The pattern of life of a river is easy to analyze through radar. Because the tracks of normal activity build up over time, the abnormal activities can be extracted based on time of day, speed, position, class of ship, interaction with the shore, and heading. Our data was analyzed over several days and identified suspicious and unusual cases. Several cases turned out to be innocuous due to the short length of the data collect, such as fishing boats that were out during non-peak fishing times, but use of radar pattern of life approaches allows improved prioritization of tracks and additional assets. The addition of a pan/tilt/zoom camera improved the usability of the system by automatically providing a quality image in a modality that was easily understandable with minimal training. Networking the images to the user also provided a greater ease-of-use. The class of ship could be determined by the radar micro-Doppler of the vessel. The arm motion of a kayaker, for example, was clearly visible even from across the river. The radar had micro-Doppler capabilities that worked even while electronically scanning across the entire river, providing continuous tracks with classification. Port security also involves detecting the docking and unloading of material that may be contraband. We demonstrate a smuggling-type scenario viewed with the same small radar and show which parts of the scenario are visible to imagers and can be measured by the radar. C1 [Silvious, Jerry; Tahmoush, Dave] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. RP Silvious, J (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. NR 7 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-2709-1 PY 2012 BP 626 EP 630 PG 5 WC Computer Science, Theory & Methods SC Computer Science GA BEZ20 UT WOS:000318851500105 ER PT B AU Zainuddin, S Hosur, M Rao, H Barua, R Jeelani, S Kumar, A Trovillion, J AF Zainuddin, Shaik Hosur, Mahesh Rao, Harish Barua, Rajib Jeelani, Shaik Kumar, Ashok Trovillion, Jonathan GP ASME TI INFLUENCE OF NON-FUNCTIONALIZED AND FUNCTIONALIZED MWCNTs ON MECHANICAL AND THERMAL PROPERTIES OF EPOXY COMPOSITES SO PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION 2010, VOL 12 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 12-18, 2010 CL Vancouver, CANADA SP Amer Soc Mech Engineers ID WALLED CARBON NANOTUBES; ELECTRICAL-PROPERTIES; POLYPROPYLENE COMPOSITES; DISPERSION PROCESS; NANOCOMPOSITES; MATRIX; BEHAVIORS; LOAD AB In this work, SC-15 epoxy resin was modified using 0.1-0.3 wt. % of non-functionalized and functionalized multi-walled carbon nanotubes (MWCNTs) using conventional and solvent based methods. A high-intensity ultrasonic liquid processor was used to disperse MWCNTs in solvent and to obtain a homogeneous molecular mixture of epoxy resin and MWCNTs. Viscosity, dynamic mechanical analysis (DMA), thermo-gravimetric analysis (TGA), tensile and flexure tests were performed on unfilled and 0.1-0.3 wt. % MWCNTs filled SC-15 epoxy. Preliminary results indicate increase in viscosity with increase in MWCNTs wt. % loading and 0.2 wt. % MWCNTs epoxy samples showed the highest improvement in tensile and flexural properties as compared to the neat system. DMA studies also revealed that 0.2 wt. % doped system exhibit the highest storage modulus and T-g as compared to neat and other loading percentages. TGA results show that amino functionalized MWCNTs samples are more thermally stable. C1 [Zainuddin, Shaik; Hosur, Mahesh; Rao, Harish; Barua, Rajib; Jeelani, Shaik] Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. [Kumar, Ashok; Trovillion, Jonathan] US Army Engn Res, Dev Ctr, Construct Engn Res Lab, Champaign, IL 61821 USA. RP Zainuddin, S (reprint author), Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. NR 26 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4449-6 PY 2012 BP 117 EP + PG 3 WC Engineering, Mechanical SC Engineering GA BFJ72 UT WOS:000320140600019 ER PT S AU Yoginath, SB Perumalla, KS Henz, BJ AF Yoginath, Srikanth B. Perumalla, Kalyan S. Henz, Brian J. BE Laroque, C Himmelspach, J Pasupathy, R TI RUNTIME PERFORMANCE AND VIRTUAL NETWORK CONTROL ALTERNATIVES IN VM-BASED HIGH-FIDELITY NETWORK SIMULATIONS SO 2012 WINTER SIMULATION CONFERENCE (WSC) SE Winter Simulation Conference Proceedings LA English DT Proceedings Paper CT Winter Simulation Conference (WSC) CY DEC 09-12, 2012 CL Berlin, GERMANY AB In prior work (Yoginath and Perumalla, 2011; Yoginath, Perumalla and Henz, 2012), the motivation, challenges and issues were articulated in favor of virtual time ordering of Virtual Machines (VMs) in network simulations hosted on multi-core machines. Two major components in the overall virtualization challenge are (1) virtual timeline establishment and scheduling of VMs, and (2) virtualization of inter-VM communication. Here, we extend prior work by presenting scaling results for the first component, with experimental results on up to 128 VMs scheduled in virtual time order on a single 12-core host. We also explore the solution space of design alternatives for the second component, and present performance results from a multi-threaded, multi-queue implementation of inter-VM network control for synchronized execution with VM scheduling, incorporated in our NetWarp simulation system. C1 [Yoginath, Srikanth B.; Perumalla, Kalyan S.] Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN 37831 USA. US Army Res Lab, Comp & Computat Sci Div, ATTN, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. RP Yoginath, SB (reprint author), Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN 37831 USA. EM yoginathsb@ornl.gov; perumallaks@ornl.gov; an.j.henz@us.army.mil NR 12 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0891-7736 BN 978-1-4673-4779-2; 978-1-4673-4780-8 J9 WINT SIMUL C PROC PY 2012 PG 13 WC Computer Science, Theory & Methods SC Computer Science GA BFD03 UT WOS:000319225503044 ER PT J AU Cornis-Pop, M Mashima, PA Roth, CR MacLennan, DL Picon, LM Hammond, CS Goo-Yoshino, S Isaki, E Singson, M Frank, EM AF Cornis-Pop, Micaela Mashima, Pauline A. Roth, Carole R. MacLennan, Donald L. Picon, Linda M. Hammond, Carol Smith Goo-Yoshino, Shari Isaki, Emi Singson, Maile Frank, Elaine M. TI Cognitive-communication rehabilitation for combat-related mild traumatic brain injury SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Editorial Material ID OF-THE-LITERATURE; POSTTRAUMATIC-STRESS-DISORDER; THERAPEUTIC WORKING ALLIANCE; RANDOMIZED CONTROLLED-TRIAL; HEAD-INJURY; ADULT ONSET; MEMORY; IRAQ; INTERVENTION; AFGHANISTAN C1 [Cornis-Pop, Micaela] Hunter Holmes McGuire VA Med Ctr, Richmond, VA USA. [Mashima, Pauline A.; Goo-Yoshino, Shari] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Roth, Carole R.] USN, Med Ctr, San Diego, CA 92152 USA. [MacLennan, Donald L.] Minnevolis VA Hlth Care Syst, Minneapolis, MN USA. [Picon, Linda M.] James A Haley Vet Hosp, Tampa, FL 33612 USA. [Picon, Linda M.] Univ S Florida, Dept Commun Sci & Disorders, Coll Behav & Community Sci, Tampa, FL USA. [Hammond, Carol Smith] Durham VA Med Ctr, Durham, NC USA. [Hammond, Carol Smith] Duke Univ, Div Gen Internal Med, Sch Med, Durham, NC USA. [Isaki, Emi] No Arizona Univ, Flagstaff, AZ 86011 USA. [Singson, Maile] VA Pacific Islands Hlth Care Syst, Honolulu, HI USA. [Frank, Elaine M.] Univ S Carolina, Dept Commun Sci & Disorders, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. RP Cornis-Pop, M (reprint author), Hunter Holmes McGuire VA Med Ctr, Richmond, VA USA. EM pauline.mashima@us.army.mil NR 112 TC 2 Z9 3 U1 4 U2 10 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2012 VL 49 IS 7 BP XI EP XXXI DI 10.1682/JRRD.2012.03.0048 PG 21 WC Rehabilitation SC Rehabilitation GA 149EZ UT WOS:000319303100002 PM 23341288 ER PT J AU Valiyaveettil, M Alamneh, Y Miller, SA Hammamieh, R Wang, Y Arun, P Wei, YL Oguntayo, S Nambiar, MP AF Valiyaveettil, Manojkumar Alamneh, Yonas Miller, Stacy-Ann Hammamieh, Rasha Wang, Ying Arun, Peethambaran Wei, Yanling Oguntayo, Samuel Nambiar, Madhusoodana P. TI Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE auditory functional genes; auditory process; blast injury; cadherin; hearing loss; neurotrauma; otoancorin; otoferlin; protocadherin; tinnitus ID INDUCED HEARING-LOSS; CU/ZN-SUPEROXIDE-DISMUTASE; GATED CALCIUM-CHANNEL; HEAT-SHOCK PROTEINS; HAIR-CELLS; INNER-EAR; NOISE OVERSTIMULATION; MOUSE COCHLEA; TIP LINK; INJURY AB The mechanisms of central auditory processing involved in auditory/vestibular injuries and subsequent tinnitus and hearing loss in Active Duty servicemembers exposed to blast are not currently known. We analyzed the expression of hearing-related genes in different regions of the brain 6 h after repeated blast exposures in mice. Preliminary data showed that the expression of the deafness-related genes otoferlin and otoancorin was significantly changed in the hippocampus after blast exposures. Differential expression of cadherin and protocadherin genes, which are involved in hearing impairment, was observed in the hippocampus, cerebellum, frontal cortex, and midbrain after repeated blasts. A series of calcium-signaling genes that are known to be involved in auditory signal processing were also found to be significantly altered after repeated blast exposures. The hippocampus and midbrain showed significant increase in the gene expression of hearing loss-related antioxidant enzymes. Histopathology of the auditory cortex showed more significant injury in the inner layer compared to the outer layer. In summary, mice exposed to repeated blasts showed injury to the auditory cortex and significant alterations in multiple genes in the brain known to be involved in age- or noise-induced hearing impairment. C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Wang, Ying; Arun, Peethambaran; Wei, Yanling; Oguntayo, Samuel; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Miller, Stacy-Ann; Hammamieh, Rasha] USA, Ctr Environm Hlth Res, Med Res & Mat Command, Ft Detrick, MD USA. RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM m.valiyaveettil@amedd.army.mil; madhusoodana.nambiar@amedd.army.mil NR 54 TC 6 Z9 8 U1 1 U2 4 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2012 VL 49 IS 7 BP 1153 EP 1162 DI 10.1682/JRRD.2011.09.0182 PG 10 WC Rehabilitation SC Rehabilitation GA 149EZ UT WOS:000319303100016 PM 23341286 ER PT J AU Genao, C St Leger, A AF Genao, Christian St Leger, Aaron GP IEEE PES TI Insight into Demand Response and Photovoltaic Source with Time of Day Pricing SO 2012 IEEE PES TRANSMISSION AND DISTRIBUTION CONFERENCE AND EXPOSITION (T&D) SE Transmission and Distribution Conference and Exposition LA English DT Proceedings Paper CT IEEE PES Transmission and Distribution Conference and Exposition CY MAY 07-10, 2012 CL Orlando, FL SP IEEE Power & Energy Soc DE Net metering; Demand response; Load management; Photovoltaic system; Renewable energy; Smart grids; Solar energy AB Many utilities are offering or plan to offer customers an option between standard and "Time-of-Day" (ToD) rates for electricity. Standard rates provide a flat rate for energy while the ToD rates are tiered. ToD rates are typically less than the standard rate during off-peak times and higher than the standard rate at peak times. This pricing structure can incentivize demand response (DR) and integration of photovoltaic (PV) generation. DR can shift energy consumption to off-peak times and PV generation typically coincides with peak rates. ToD pricing has the potential to reduce energy costs with DR and facilitate integration of PV energy sources. This paper presents results of a study on integrating a form of demand response and photovoltaic generation with ToD pricing. An example is presented on a residential home located in New York City Suburbs. Our findings for this example show that ToD pricing can be beneficial for customers that engage in Demand Response, however, nominal benefits are seen in conjunction with Photovoltaic energy sources. C1 [Genao, Christian; St Leger, Aaron] US Mil Acad, West Point, NY 10996 USA. RP Genao, C (reprint author), US Mil Acad, West Point, NY 10996 USA. EM aaron.stleger@usma.edu NR 11 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-1935-5 J9 TRANS DISTRIB CONF PY 2012 PG 8 WC Energy & Fuels; Engineering, Electrical & Electronic SC Energy & Fuels; Engineering GA BEJ78 UT WOS:000317001100229 ER PT S AU Mason, R Gintert, L Sweeney, S Lampo, R Chandler, K Chandler, J AF Mason, R. Gintert, L. Sweeney, S. Lampo, R. Chandler, K. Chandler, J. BE Flammini, F TI Structural health monitoring SO CRITICAL INFRASTRUCTURE SECURITY: ASSESSMENT, PREVENTION, DETECTION, RESPONSE SE WIT Transactions on State of the Art in Science and Engineering LA English DT Article; Book Chapter DE Structural Health Monitoring; Structural Health Management; Bridges; Corrosion; Infrastructure; Sensors; Fiber Bragg Gratings AB The monitoring of infrastructure for structural integrity continues to be a critical need. The potential for structural failure-due to phenomena related to material and component degradation over time (corrosion) as well as instantaneous occurrences such as earthquakes and terrorist attacks-is a growing concern as bridges and buildings are becoming older yet more heavily used. Structural integrity concerns are traditionally addressed through regular inspection of the structure, which may include visual, dye penetrant, ultrasonic, and/or radiographic nondestructive test methods. These methods are capable of detecting most defects of concern to authorities, but some of the methods may not detect defects (such as corrosion or cracks) in structural members that are completely hidden, and none of them are able to determine (in a single measurement) if a defect is actively growing. As a result, standard inspection techniques may not find defects that are likely to compromise integrity and could instead focus attention on defects that, while readily detectable, may be harmless to the overall health of the structure. State-of-the-art and emerging sensor technology approaches are available that can assess structural integrity in real time. Furthermore, these technologies can be integrated into a comprehensive remote monitoring system that can continuously assess the structural health of a building or a bridge, facilitating the rapid repair of potential issues. C1 [Mason, R.; Gintert, L.] Concurrent Technol Corp, Largo, FL 33773 USA. [Sweeney, S.; Lampo, R.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Mat & Struct Branch, Champaign, IL 61826 USA. [Chandler, K.; Chandler, J.] Chandler Monitoring Syst Inc, Lawrenceville, GA 30043 USA. RP Mason, R (reprint author), Concurrent Technol Corp, Largo, FL 33773 USA. NR 20 TC 0 Z9 0 U1 0 U2 1 PU WIT PRESS PI SOUTHAMPTON PA ASHURST LODGE, SOUTHAMPTON SO40 7AA, ASHURST, ENGLAND SN 1755-8336 BN 978-1-84564-562-5 J9 WIT T STATE ART SCI PY 2012 VL 54 BP 221 EP 232 PG 12 WC Computer Science, Information Systems SC Computer Science GA BEZ50 UT WOS:000318898700015 ER PT J AU Schnall, BL Wolf, EJ Bell, JC Gambel, J Bensel, CK AF Schnall, Barri L. Wolf, Erik J. Bell, Johanna C. Gambel, Jeffrey Bensel, Carolyn K. TI Metabolic analysis of male servicemembers with transtibial amputations carrying military loads SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE Borg Rating of Perceived Exertion; energy consumption; limb loss; load carriage; locomotion; military; return to duty; transtibial; treadmill; unilateral ID TRANS-TIBIAL AMPUTEES; BELOW-KNEE AMPUTEES; ENERGY-EXPENDITURE; PHYSIOLOGICAL-RESPONSES; PERCEIVED EXERTION; MEDICAL ASPECTS; COST; WALKING; CARRIAGE; AMBULATION AB For servicemembers who have sustained amputations and wish to return to Active Duty, performing common military tasks is essential. The purpose of this study was to examine the metabolic requirements of servicemembers with transtibial amputations wearing a loaded ru.cksack and walking at a steady speed. We tested 12 servicemembers with unilateral transtibial amputations and 12 uninjured controls on a treadmill at two walking speeds (1.34 and 1.52 m/s) while they carried a 32.7 kg load. Oxygen consumption was recorded. Results showed that metabolic demand for the injured servicemembers was significantly higher (8.5% at 1.34 m/s and 10.4% at 1.52 m/s) than for controls. An understanding of energy expended during load carriage by this study population is critical for decisions regarding return-to-duty requirements. Although significant differences existed between uninjured controls and those with amputations, it is important to note that those differences are less than previously published. This fmding, coupled with the fact that servicemembers with transtibial amputations have redeployed, implies that, despite statistical significance, results may not be clinically relevant. Future work should include more taxing conditions to identify a threshold for potential limitations. C1 [Schnall, Barri L.; Wolf, Erik J.; Bell, Johanna C.; Gambel, Jeffrey] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Wolf, Erik J.; Bell, Johanna C.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Bensel, Carolyn K.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Schnall, BL (reprint author), Walter Reed Natl Mil Med Ctr, Ctr Performance & Clin Res, Mil Adv Training Ctr, Amer Bldg 19,B-322,8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM barri.schnall@med.navy.mil OI Wolf, Erik/0000-0002-6353-7978 FU U.S. Army Medical Research and Materiel Command [W81XWH-06-2-0073] FX This material was based on work supported by the U.S. Army Medical Research and Materiel Command (award W81XWH-06-2-0073). NR 30 TC 3 Z9 3 U1 0 U2 4 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2012 VL 49 IS 4 BP 535 EP 543 DI 10.1682/JRRD.2011.04.0075 PG 9 WC Rehabilitation SC Rehabilitation GA 149EV UT WOS:000319302700006 PM 22773257 ER PT J AU Wolf, EJ Everding, VQ Linberg, AL Schnall, BL Czerniecki, JM Gambel, JM AF Wolf, Erik J. Everding, Vanessa Q. Linberg, Alison L. Schnall, Bard L. Czerniecki, Joseph M. Gambel, Jeffrey M. TI Assessment of transfemoral amputees using C-Leg and Power Knee for ascending and descending inclines and steps SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE amputation; ankle; biomechanics; hip; kinetics; knee; power; prosthesis; servicemember; unilateral ID LOWER-LIMB AMPUTEES; TRANS-TIBIAL AMPUTEES; PROSTHETIC KNEE; WALKING SPEED; BACK-PAIN; GAIT; OSTEOARTHRITIS; HIP; PREFERENCE; KINEMATICS AB Adding active power to a prosthetic knee unit may improve function and reduce the potential for overuse injuries in persons with transfemoral amputation (TFA). Servicememhers who have sustained a TFA are often young and motivated to perform at high functional levels. The goal of this article is to compare the biomechanics of ramp and stair descent and ascent for participants using the C-Leg and the Power Knee (PK). Subjects were asked to ascend and descend an instrumented staircase and 12 degree ramp at their comfortable pace while equipped with retroreflective markers. Temporal-spatial and kinetic data were collected. Knee power generated by the nondisabled limb during stair ascent for subjects wearing the C-Leg was significantly greater than for those wearing the PK. Knee power generated by prosthetic knee units was significantly greater for subjects while wearing the PK. Although the PK reduced the power required from the nondisabled knee during stair climbing, it does not appear to be superior to the C-Leg for other tasks. Adding power to a prosthetic knee may reduce wear on the nondisabled limb; however, there are still limitations that require improvement. C1 [Wolf, Erik J.; Linberg, Alison L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA. [Wolf, Erik J.; Everding, Vanessa Q.; Linberg, Alison L.; Schnall, Bard L.; Gambel, Jeffrey M.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Czerniecki, Joseph M.] Dept Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA. [Czerniecki, Joseph M.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA. RP Wolf, EJ (reprint author), Walter Reed Natl Mil Med Ctr, Amer Bldg 19,Room B322,8901 Rockville Pike, Bethesda, MD 20889 USA. EM erik.wolf@med.navy.mil OI Wolf, Erik/0000-0002-6353-7978 FU Military Amputee Research Program FX This material was based on work supported by the Military Amputee Research Program. NR 26 TC 7 Z9 7 U1 0 U2 16 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2012 VL 49 IS 6 BP 831 EP 842 DI 10.1682/JRRD.2010.12.0234 PG 12 WC Rehabilitation SC Rehabilitation GA 149EX UT WOS:000319302900002 PM 23299255 ER PT J AU Capo-Aponte, JE Tarbett, AK Urosevich, TG Temme, LA Sanghera, NK Kalich, ME AF Capo-Aponte, Jose E. Tarbett, Aaron K. Urosevich, Thomas G. Temme, Leonard A. Sanghera, Navjit K. Kalich, Melvyn E. TI Effectiveness of computerized oculomotor vision screening in a military population: Pilot study SO JOURNAL OF REHABILITATION RESEARCH AND DEVELOPMENT LA English DT Article DE accommodation; binocular vision; computerized oculomotor vision screening; mTBI; oculomotor function; TBI; traumatic brain injury; vergence; version; vision ID TRAUMATIC BRAIN-INJURY; RANDOMIZED CLINICAL-TRIAL; POLYTRAUMA NETWORK SITE; DUAL SENSORY IMPAIRMENT; CONVERGENCE INSUFFICIENCY; VISUAL FUNCTION; REHABILITATION; RECOVERY; DYSFUNCTION; REDUCTION AB The prevalence of oculomotor dysfunctions associated with blast-induced mild traumatic brain injury (mTBI) in warfighters has increased as a consequence of recent conflicts. This study evaluated the effectiveness of computerized oculomotor vision screening (COVS) in a military population. Oculomotor functions were assessed with COVS and by conventional methods in 20 U.S. military personnel with and 20 without mTBI. The validity of COVS was determined by Pearson correlation and Bland-Altman method or the kappa coefficient. The repeatability of the COVS was assessed with the coefficient of repeatability or the kappa coefficient. The results showed that COVS had high sensitivity and specificity for screening near oculomotor functions. Overall, the COVS showed excellent validity and repeatability for assessing near lateral and vertical phorias, Worth 4 Dot, and fixation, as well as pursuit and saccadic eye movements. Despite the strong Pearson correlation, the Bland-Altman analysis identified minor to moderate discrepancies for both positive and negative fusional vergence and their associated recovery as well as for the monocular accommodative facility measurements. This study demonstrated that non-eye-care professionals may be able to use the COVS as a tool to efficiently screen oculomotor functions in a military population with or without mTBI. C1 [Capo-Aponte, Jose E.; Urosevich, Thomas G.; Temme, Leonard A.; Kalich, Melvyn E.] USA, Visual Sci Branch, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Tarbett, Aaron K.] Walter Reed Natl Mil Med Ctr, Optometry Serv, Bethesda, MD USA. [Sanghera, Navjit K.] Illinois Coll Optometry, Clin Serv, Chicago, IL USA. RP Capo-Aponte, JE (reprint author), USA, Visual Sci Branch, Aeromed Res Lab, Ft Rucker, AL 36362 USA. EM jose.capoaponte@us.army.mil FU USAARL FX This material is based on work supported with resources and funding from the USAARL. NR 50 TC 9 Z9 9 U1 0 U2 5 PU JOURNAL REHAB RES & DEV PI BALTIMORE PA DEPT OF VETERANS AFFAIRS REHABIL RES & DEVELOP CTR 103 SOUTH GAY STREET, BALTIMORE, MD 21202-4051 USA SN 0748-7711 J9 J REHABIL RES DEV JI J. Rehabil. Res. Dev. PY 2012 VL 49 IS 9 BP 1377 EP 1398 DI 10.1682/JRRD.2011.07.0128 PG 22 WC Rehabilitation SC Rehabilitation GA 149FB UT WOS:000319303300009 PM 23408219 ER PT B AU Deery, P AF Deery, Patrick BE Sauser, WI Sims, RR TI TEXTS, E-MAILS, AND GOOGLE SEARCHES: Training in a Multigenerational Workplace SO MANAGING HUMAN RESOURCES FOR THE MILLENNIAL GENERATION SE Contemporary Human Resource Management Issues Challenges and Opportunities LA English DT Article; Book Chapter C1 [Deery, Patrick] Auburn Univ, Auburn, AL 36849 USA. [Deery, Patrick] USA, Washington, DC USA. RP Deery, P (reprint author), Auburn Univ, Auburn, AL 36849 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-62396-052-0 J9 CONT HUM RES MANAG PY 2012 BP 229 EP 247 PG 19 WC Management SC Business & Economics GA BEN27 UT WOS:000317436300010 ER PT J AU DeArmond, IM AF DeArmond, Isabelle M. TI THE PSYCHOLOGICAL EXPERIENCE OF HOSPICE WORKERS DURING ENCOUNTERS WITH DEATH SO OMEGA-JOURNAL OF DEATH AND DYING LA English DT Article ID POSTTRAUMATIC GROWTH INVENTORY; OF-LIFE CARE; COMPASSION FATIGUE; BURNOUT; NURSES; PROFESSIONALS; PHYSICIANS AB While the nature of their experience is unknown, hospice workers may unconsciously strive for encounters with death as a way of healing themselves and preparing for death. The purpose of this case study was to explore the psychological experience of hospice workers, whose repeated encounters with death may affect their own psyche. The study integrated psycho-biographical and hermeneutic methods. Personal growth was conceptually defined as a process of turning inward and integration of personal experiences into a larger reality. The elements supporting personal growth were present in 53 to 88% of the 17 hospice workers of the sample. The emerging themes were interconnectedness, suffering and sacrifice, and birth and rebirth. Caring to the dying becomes practice for one's own death and a form of renewal in the life of the hospice workers. C1 [DeArmond, Isabelle M.] San Diego Hosp, San Diego, CA USA. RP DeArmond, IM (reprint author), Mendocino Coast Clin Inc, 855 Sequoia Circle, Ft Bragg, CA 95437 USA. EM isabelleraizon@yahoo.com NR 41 TC 1 Z9 1 U1 1 U2 8 PU BAYWOOD PUBL CO INC PI AMITYVILLE PA 26 AUSTIN AVE, PO BOX 337, AMITYVILLE, NY 11701 USA SN 0030-2228 J9 OMEGA-J DEATH DYING JI Omega-J. Death Dying PY 2012 VL 66 IS 4 BP 281 EP 299 DI 10.2190/OM.66.4.a PG 19 WC Psychology, Multidisciplinary; Social Sciences, Biomedical SC Psychology; Biomedical Social Sciences GA 129JD UT WOS:000317834400001 PM 23785981 ER PT J AU Khan, F Legler, PM Mease, RM Duncan, EH Bergmann-Leitner, ES Angov, E AF Khan, Farhat Legler, Patricia M. Mease, Ryan M. Duncan, Elizabeth H. Bergmann-Leitner, Elke S. Angov, Evelina TI Histidine affinity tags affect MSP1(42) structural stability and immunodominance in mice SO BIOTECHNOLOGY JOURNAL LA English DT Article DE Histidine tag; Immune deviation; Immunodominance; Neo-epitope; Protein structure ID MEROZOITE SURFACE PROTEIN-1; PLASMODIUM-FALCIPARUM; RECOMBINANT PROTEINS; MONOCLONAL-ANTIBODY; ESCHERICHIA-COLI; FINE-SPECIFICITY; SERUM ANTIBODIES; MALARIA VACCINE; TAGGED PROTEIN; BINDING-SITE AB Inclusion of affinity tags has greatly facilitated process development for protein antigens, primarily for their recovery from complex mixtures. Although generally viewed as supportive of product development, affinity tags may have unintended consequences on protein solubility, susceptibility to aggregation, and immunogenicity. Merozoite surface protein 1 (MSP1), an erythrocytic stage protein of Plasmodium falciparum and a candidate malaria vaccine, was used to evaluate the impact of a metal ion affinity-tag on both protein structure and the induction of immunity. To this end, codon harmonized gene sequences from the P. falciparum MSP1(42) of FVO and 3D7 parasites were cloned and purified with and without a histidine (His) tag. We report on the influence of His-affinity tags on protein expression levels, solubility, secondary structure, thermal denaturation, aggregation and the impact on humoral and cellular immune responses in mice. While the overall immunogenicity induced by His-tagged MSP1(42) proteins is greater, the fine specificity of the humoral and cellular immune responses is altered relative to anti-parasitic antibody activity and the breadth of T-cell responses. Thus, the usefulness of protein tags may be outweighed by their potential impact on structure and function, stressing the need for caution in their use. C1 [Khan, Farhat; Mease, Ryan M.; Duncan, Elizabeth H.; Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, Silver Spring, MD 20910 USA. [Legler, Patricia M.] USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA. RP Angov, E (reprint author), Walter Reed Army Inst Res, Mil Malaria Res Program, Malaria Vaccine Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Evelina.angov@us.army.mil RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 FU U.S. Agency for International Development [936-3118, GHA-T-00-08-00007-01]; United States Army Medical Research and Materiel Command FX We thank Dr. Carissa M. Soto at the Naval Research Laboratories for assistance and use of the NanoSight particle tracking system. This work was supported by the U.S. Agency for International Development under project number 936-3118, award number GHA-T-00-08-00007-01, and by the United States Army Medical Research and Materiel Command. NR 56 TC 25 Z9 26 U1 1 U2 12 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1860-6768 J9 BIOTECHNOL J JI Biotechnol. J. PD JAN PY 2012 VL 7 IS 1 SI SI BP 133 EP 147 DI 10.1002/biot.201100331 PG 15 WC Biochemical Research Methods; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 133PS UT WOS:000318151900006 PM 22076863 ER PT J AU Arciero, CA Shiue, ZS Gates, JD Peoples, GE Dackiw, APB Tufano, RP Libutti, SK Zeiger, MA Stojadinovic, A AF Arciero, Cletus A. Shiue, Zita S. Gates, Jeremy D. Peoples, George E. Dackiw, Alan P. B. Tufano, Ralph P. Libutti, Steven K. Zeiger, Martha A. Stojadinovic, Alexander TI Preoperative Thyroid Ultrasound Is Indicated in Patients Undergoing Parathyroidectomy for Primary Hyperparathyroidism SO JOURNAL OF CANCER LA English DT Article DE hyperparathyroidism; thyroid; ultrasound; surgery; thyroid cancer ID CANCER; DISEASE; SURGERY; NODULES; GLAND AB Background: Primary hyperaparathyroidism (pHPT) is often accompanied by underlying thyroid pathology that can confound preoperative parathyroid localization studies and complicate intra-operative decision making. The aim of this study was to examine the utility of preoperative thyroid ultrasonography (US) in patients prior to undergoing parathyroidectomy for pHPT. Methods: An Institutional Review Board approved prospective study was undertaken from January 2005 through July 2008. All patients with pHPT meeting inclusion criteria (n=94) underwent preoperative thyroid ultrasound in addition to standard Tc-99m-sestamibi scintigraphy for parathyroid localization. Demographics, operative management and final pathology were examined in all cases. Results: Fifty-four of the 94 patients (57%) were noted to have a thyroid nodule on preoperative US, of which 30 (56%) underwent further examination with fine needle aspiration biopsy. Alteration of the operative plan attributable to underlying thyroid pathology occurred in 16 patients (17%), with patients undergoing either total thyroidectomy (n=9) or thyroid lobectomy (n=7). Thyroid cancer was noted in 33% of patients undergoing thyroid resection, and 6% of all patients with HPT. Conclusions: The routine utilization of preoperative thyroid ultrasound in patients prior to undergoing parathyroid surgery for pHPT is indicated. The added information from this non-invasive modality facilitates timely management of co-incidental, and sometimes malignant, thyroid pathology. C1 [Arciero, Cletus A.] Eisenhower Army Med Ctr, Ft Gordon, GA USA. [Shiue, Zita S.] Univ Washington, Seattle, WA 98195 USA. [Gates, Jeremy D.] Martin Army Community Hosp, Ft Benning, GA USA. [Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Peoples, George E.; Stojadinovic, Alexander] United States Mil Canc Inst, Washington, DC USA. [Peoples, George E.; Stojadinovic, Alexander] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Dackiw, Alan P. B.; Tufano, Ralph P.; Zeiger, Martha A.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. [Libutti, Steven K.] Albert Einstein Coll Med, Montefiore Med Ctr, New York, NY USA. [Libutti, Steven K.; Stojadinovic, Alexander] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA. RP Arciero, CA (reprint author), Eisenhower Army Med Ctr, Dept Surg, Div Surg Oncol, Ft Gordon, GA USA. EM cletus.arciero@us.army.mil NR 27 TC 8 Z9 11 U1 0 U2 1 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2012 VL 3 BP 1 EP 6 DI 10.7150/jca.3.1 PG 6 WC Oncology SC Oncology GA 135PD UT WOS:000318299800001 PM 22211139 ER PT J AU Henry, LR Helou, LB Solomon, NP Chang, A Libutti, SK Stojadinovic, A AF Henry, L. R. Helou, L. B. Solomon, N. P. Chang, A. Libutti, S. K. Stojadinovic, A. TI Current Practice Patterns Regarding the Conduct of Thyroidectomy and Parathyroidectomy amongst Surgeons - A Survey Study SO JOURNAL OF CANCER LA English DT Article DE thyroidectomy; survey; neuromonitoring; laryngeal nerve ID RECURRENT LARYNGEAL NERVE; EXTERNAL BRANCH; HARMONIC SCALPEL; VOICE OUTCOMES; IDENTIFICATION; EPIDEMIOLOGY; DISEASE; TRIAL; RISK; PREVALENCE AB 4 Background: Heterogeneity of surgical care exists among surgeons regarding the conduct of thyroidectomy and parathyroidectomy. Aim: To identify the current patterns of technical conduct of operation amongst surgeons performing thyroidectomy or parathyroidectomy. Methods: A survey was designed and beta-tested on five surgical oncologists for face validity and usability. The final version of this survey was constructed and disseminated using the professional version of the internet-based survey mechanism Survey Monkey and consisted of two eligibility questions and 22 questions regarding thyroidectomy/parathyroidectomy treatment patterns. The survey was disseminated electronically to American Association of Endocrine Surgeons (AAES) and American College of Surgeons (ACS) members. Survey results were collected, tabulated and analyzed. Responses among groups were compared using two sample T- tests. Significant responses were subsequently analyzed in generalized linear models to ascertain if significance remained with control of covariates. Results: Of 420 initial web survey visits, 236 (56.2%) surveys were completed. The majority of respondents reported being 'fellowship trained', experienced and 'high-volume' surgeons. The most common fellowship trainings were endocrine (46%), oncology (22%), head & neck (13%), or combinations of the three fellowships (14%). Most surgeons reported that they dissect the course of the recurrent laryngeal nerve (RLN) without using neuromonitoring. Nearly a third of respondents reported routinely using the Harmonic scalpel during the conduct of the operations. Significant differences emerged regarding operative technique according to residency training type, fellowship training, surgeon volume, and practice setting, but only those associated with residency training type and annual surgeon surgical volume remained significant within generalized linear models. Conclusion: Most surgeons who responded to this survey do not routinely use RLN neuromonitoring and most dissect the RLN during thyroidectomy. There are multiple variations in technique according to surgical training, surgeon volume, experience, and practice setting; however, only differences by residency training type and surgeon volume remained correlated significantly to surgeons' approaches to thyroidectomy and parathyroidectomy in multivariate analysis. These data may be useful for surgeons reflecting upon their individual practice, as well as for further defining current standards of practice from a medico legal perspective. C1 [Henry, L. R.] Indiana Univ Hlth, Goshen Ctr Canc Care, Indiana, PA USA. [Helou, L. B.] Univ Pittsburgh, Pittsburgh, PA USA. [Solomon, N. P.; Chang, A.; Stojadinovic, A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Libutti, S. K.] Montefiore Med Ctr, New York, NY USA. RP Stojadinovic, A (reprint author), Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD USA. FU ARAPMI FX Supported by the ARAPMI. NR 31 TC 4 Z9 4 U1 0 U2 2 PU IVYSPRING INT PUBL PI LAKE HAVEN PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA SN 1837-9664 J9 J CANCER JI J. Cancer PY 2012 VL 3 BP 207 EP 216 DI 10.7150/jca.4452 PG 10 WC Oncology SC Oncology GA 135PD UT WOS:000318299800028 PM 22606210 ER PT J AU Yu, W Zhang, N Fu, XW Rivera, B AF Yu, Wei Zhang, Nan Fu, Xinwen Rivera, Brian BA Das, SK Kant, K Zhang, N BF Das, SK Kant, K Zhang, N TI Evolution of Widely Spreading Worms and Countermeasures: Epidemic Theory and Application SO HANDBOOK ON SECURING CYBER-PHYSICAL CRITICAL INFRASTRUCTURE: FOUNDATIONS AND CHALLENGES LA English DT Article; Book Chapter C1 [Zhang, Nan] George Washington Univ, Dept Comp Sci, Washington, DC 20052 USA. [Fu, Xinwen] Univ Massachusetts, Dept Comp Sci, Lowell, MA USA. [Rivera, Brian] USA, Res Lab, Tact Network Assurance Branch, Washington, DC USA. EM wyu@towson.edu; nzhang10@gwu.edu; xinwenfu@cs.uml.edu; brian.rivera1@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU MORGAN KAUFMANN PUB INC PI SAN FRANCISCO PA 340 PINE STR, 6TH FLR, SAN FRANCISCO, CA 94104-3205 USA BN 978-0-12-415910-5 PY 2012 BP 73 EP 98 DI 10.1016/B978-0-12-415815-3.00004-2 PG 26 WC Computer Science, Information Systems SC Computer Science GA BEK50 UT WOS:000317077000007 ER PT S AU Cahill, JP Okusaga, O White, JO AF Cahill, James P. Okusaga, Olukayode White, Jeffrey O. GP IEEE TI Suppression of Stimulated Brillouin Scattering in High Power, Low Phase Noise RF-Photonic Links SO 2012 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (FCS) SE IEEE International Frequency Control Symposium LA English DT Proceedings Paper CT IEEE International Frequency Control Symposium (IFCS) CY MAY 21-24, 2012 CL Baltimore, MD SP IEEE, UFFC ID OPTICAL-FIBERS AB Stimulated Brillouin scattering (SBS) degrades the performance of ultra-low phase noise RF-photonic links by limiting the optical power that can be transmitted through the optical fiber. While SBS can be suppressed with a variety of methods, existing techniques conflict with the demands of RF-photonic links that require the lowest phase noise. In this work, we present a new technique that is compatible with these systems. We demonstrate that by concatenating spools of Corning SMF-28 fiber with different Brillouin frequency shifts, it is possible to decrease the total power reflected in the SBS process by at least 7 dB. This corresponds to an increase in the optical power that can be transmitted through the fiber. C1 [Cahill, James P.] Univ Maryland Baltimore Cty, Dept Comp Sci & Elec Eng, Baltimore, MD 21228 USA. [Okusaga, Olukayode; White, Jeffrey O.] U S Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Cahill, JP (reprint author), Univ Maryland Baltimore Cty, Dept Comp Sci & Elec Eng, Baltimore, MD 21228 USA. EM james.p.cahill.ctr@us.army.mil FU Office of the Secretary of Defense under the Coalition Warfare Program; High Energy Lasers Joint Technology Office (HEL-JTO). FX This work was supported in part by the Office of the Secretary of Defense under the Coalition Warfare Program and by the High Energy Lasers Joint Technology Office (HEL-JTO). NR 7 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1075-6787 BN 978-1-4577-1819-9 J9 P IEEE INT FREQ CONT PY 2012 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BEJ76 UT WOS:000316994400040 ER PT S AU Docherty, A Menyuk, CR Okusaga, O Zhou, WM AF Docherty, Andrew Menyuk, Curtis R. Okusaga, Olukayode Zhou, Weimin GP IEEE TI Stimulated Rayleigh scattering and amplitude-to-phase conversion as a source of length-dependent phase noise in OEOs SO 2012 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (FCS) SE IEEE International Frequency Control Symposium LA English DT Proceedings Paper CT IEEE International Frequency Control Symposium (IFCS) CY MAY 21-24, 2012 CL Baltimore, MD SP IEEE, UFFC ID OPTOELECTRONIC OSCILLATORS AB Optical fiber-length-dependent flicker phase noise has been identified as a major limit to the reduction of phase noise in opto-electronic oscillators (OEOs). We demonstrate that in our system the largest contributor to low-frequency flicker noise is from Rayleigh scattering through the fiber combined with amplitude-to-phase conversion in the RF amplifiers. C1 [Docherty, Andrew; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, 1000 Hilltop Circle, Baltimore, MD 21250 USA. [Okusaga, Olukayode; Zhou, Weimin] US Army Res Lab, Adelphi, MD 20783 USA. RP Docherty, A (reprint author), Univ Maryland Baltimore Cty, 1000 Hilltop Circle, Baltimore, MD 21250 USA. NR 14 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1075-6787 BN 978-1-4577-1819-9 J9 P IEEE INT FREQ CONT PY 2012 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BEJ76 UT WOS:000316994400021 ER PT S AU Okusaga, O Zhou, WM Cahill, J Docherty, A Menyuk, CR AF Okusaga, Olukayode Zhou, Weimin Cahill, James Docherty, Andrew Menyuk, Curtis R. GP IEEE TI Fiber-Induced Degradation in RF-over-Fiber Links SO 2012 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (FCS) SE IEEE International Frequency Control Symposium LA English DT Proceedings Paper CT IEEE International Frequency Control Symposium (IFCS) CY MAY 21-24, 2012 CL Baltimore, MD SP IEEE, UFFC ID RAYLEIGH-SCATTERING; OPTICAL-FIBERS AB Optical fiber induced noise limits the noise performance of several radio frequency (RF) over fiber links. In this work, we characterize the effects of Rayleigh scattering on the intensity and phase noise of RF signals transmitted via optical fibers. In addition, we investigate laser frequency modulation as a means of suppressing Rayleigh-induced RF intensity and phase noise. We find the optimal frequency range for laser frequency modulation and demonstrate up to 30 dB suppression of fiber induced noise. C1 [Okusaga, Olukayode; Zhou, Weimin] USA, Sensors & Elect Devices Div, Res Lab, Adelphi, MD 20783 USA. [Cahill, James; Docherty, Andrew; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Dept Comp Sci & Elect Engn, Baltimore, MD USA. RP Okusaga, O (reprint author), USA, Sensors & Elect Devices Div, Res Lab, Adelphi, MD 20783 USA. EM Olukayode.k.okusaga.civ@mail.mil FU Office of the Secretaryof Defense via the Coalition Warfare Program FX This work was funded by the Office of the Secretaryof Defense via the Coalition Warfare Program. NR 8 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1075-6787 BN 978-1-4577-1819-9 J9 P IEEE INT FREQ CONT PY 2012 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BEJ76 UT WOS:000316994400077 ER PT S AU Yamamoto, KK Vecherin, SN Wilson, DK Borden, CT Bettencourt, E Pettit, CL AF Yamamoto, Kenneth K. Vecherin, Sergey N. Wilson, D. Keith Borden, Christian T. Bettencourt, Elizabeth Pettit, Chris L. BE Pritchard, DA TI General Software for Multimodal Signal Modeling and Optimal Sensor Placement Environmental Awareness for Sensor and Emitter Employment (EASEE) SO 46TH ANNUAL 2012 IEEE INTERNATIONAL CARNAHAN CONFERENCE ON SECURITY TECHNOLOGY SE International Carnahan Conference on Security Technology Proceedings LA English DT Proceedings Paper CT 46th Annual IEEE International Carnahan Conference on Security Technology (ICCST) CY OCT 15-18, 2012 CL Boston, MA SP IEEE, Chung Shan Inst Sci, IEEE Aerosp & Elect Syst Soc (AESS), Natl Cent Univ, Sandia Natl Labs, Volpe Ctr, FLIR, US Amer, Dept Transformat DE intrusion detection; sensors; surveillance; signal modeling; environmental effects; decision-support tool; homeland security; mission planning; battlefield command and control (C2); object-oriented programming ID CONCENTRATION FLUCTUATIONS; SOUND-PROPAGATION; PLUMES AB The Environmental Awareness for Sensor and Emitter Employment (EASEE) software is designed to help in surveillance planning by predicting detection performance of sensors and optimizing sensor selection and placement for intrusion detection around any controlled area, including power plants, dams, borders, prisons, military bases, combat outposts, etc. By its flexible, object-oriented software architecture, EASEE can simulate the performance of a wide variety of sensor modalities-including optical, acoustic, seismic, magnetic, radio-frequency, chemical, and biological-in the realistic terrain and weather conditions of the surveillance environment. EASEE characterizes complex terrain and weather effects on target signatures, signal propagation, and sensor systems, using an expansive library of realistic physics models. Statistical methodologies are also used to account for uncertainties from random signal-generation and propagation mechanisms. A built-in sensor placement algorithm optimizes sensor selections and placements based on sensor supply limitations, coverage priorities, overlapping sensor coverage preferences, and wireless sensor communication requirements. C1 [Yamamoto, Kenneth K.; Vecherin, Sergey N.; Wilson, D. Keith] USA, ERDC CRREL, Hanover, NH 02420 USA. [Borden, Christian T.; Bettencourt, Elizabeth] AER Inc, Lexington, MA 02421 USA. [Pettit, Chris L.] US Naval Acad, Annapolis, MD 21402 USA. RP Yamamoto, KK (reprint author), USA, ERDC CRREL, Hanover, NH 02420 USA. EM Kenneth.K.Yamamoto@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU U.S. Army ERDC Geospatial Research and Engineering; Military Engineering; ASA(ALT) Deployable Force Protection S&T Program Leaders Mission Planning Tool (LMPT); Postgraduate Research Participation Program at the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL); Oak Ridge Institute for Science and Education (ORISE); U.S. Department of Energy; CRREL FX Funding for this effort was provided by the U.S. Army ERDC Geospatial Research and Engineering, and Military Engineering business areas, and by the ASA(ALT) Deployable Force Protection S&T Program Leaders Mission Planning Tool (LMPT) project. Development of the EASEE- Raptor interface described in Section V is part of the LMPT project, which is led by the U.S. Army Night Vision and Electronic Sensors Directorate. Dr. Vecherin's work was performed during an appointment to the Postgraduate Research Participation Program at the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL) administrated by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and CRREL. NR 23 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1071-6572 BN 978-1-4673-2451-9 J9 INT CARN CONF SECU PY 2012 BP 66 EP 77 PG 12 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BEJ66 UT WOS:000316952800010 ER PT S AU Shay, LA Conti, G Larkin, D Nelson, J AF Shay, Lisa A. Conti, Gregory Larkin, Dominic Nelson, John BE Pritchard, DA TI A Framework for Analysis of Quotidian Exposure in an Instrumented World SO 46TH ANNUAL 2012 IEEE INTERNATIONAL CARNAHAN CONFERENCE ON SECURITY TECHNOLOGY SE International Carnahan Conference on Security Technology Proceedings LA English DT Proceedings Paper CT 46th Annual IEEE International Carnahan Conference on Security Technology (ICCST) CY OCT 15-18, 2012 CL Boston, MA SP IEEE, Chung Shan Inst Sci, IEEE Aerosp & Elect Syst Soc (AESS), Natl Cent Univ, Sandia Natl Labs, Volpe Ctr, FLIR, US Amer, Dept Transformat DE Privacy; instrumented life; sensors; surveillance; dataveillance; uberveillance; surveillance society; panopticon ID UBERVEILLANCE AB For a variety of often reasonable motives such as increased security or increased profit, individuals and organizations fill our world with sensors and data collection systems that sample and track our day-to-day activities. Some people freely invite tracking into their lives. Others are enticed by offers of discounts or even free products and services. But frequently our lives are quietly sampled, unbeknownst to us, by those with the power to do so. As a result, individuals face a rapidly declining freedom to lead a private life. While significant sampling and tracking occur online, this study focuses on the convergence of sensor systems in the physical world. It explores the privacy implications of sensors found on our person, in our home, in our communities, and while travelling. This paper provides the following contributions: a model of human-targeted sensor systems and a framework for sensor categorization, privacy threat analysis, and countermeasure development. It concludes with a detailed case study that employs the framework to analyze the quotidian exposure encountered in an ordinary citizen's life. C1 [Shay, Lisa A.; Conti, Gregory; Larkin, Dominic; Nelson, John] US Mil Acad, Cyber Res Ctr, West Point, NY 10996 USA. RP Shay, LA (reprint author), US Mil Acad, Cyber Res Ctr, West Point, NY 10996 USA. EM Lisa.Shay@usma.edu; Gregory.Conti@usma.edu; Dominic.Larkin@usma.edu; John.Nelson@usma.edu NR 26 TC 2 Z9 2 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1071-6572 BN 978-1-4673-2451-9 J9 INT CARN CONF SECU PY 2012 BP 126 EP 134 PG 9 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BEJ66 UT WOS:000316952800018 ER PT S AU Wang, BS Chen, F Dong, HL Boedihardjo, AP Lu, CT AF Wang, Bingsheng Chen, Feng Dong, Haili Boedihardjo, Arnold P. Lu, Chang-Tien BE Zaki, MJ Siebes, A Yu, JX Goethals, B Webb, G Wu, X TI Signal Disaggregation via Sparse Coding with Featured Discriminative Dictionary SO 12TH IEEE INTERNATIONAL CONFERENCE ON DATA MINING (ICDM 2012) SE IEEE International Conference on Data Mining LA English DT Proceedings Paper CT 12th IEEE International Conference on Data Mining (ICDM) CY DEC 10-13, 2012 CL Brussels, BELGIUM SP IEEE, IEEE Comp Soc (CS), Natl Sci Fdn (NSF), FWO, IBM, SAS, Yahoo, NASA, Biside, KNIME, Univ Antwerpen, Univ Libre Bruxelles (ULB) AB As the issue of freshwater shortage is increasing daily, it's critical to take effective measures for water conservation. Based on previous studies, device level consumption could lead to significant conservation of freshwater. However, current smart meter deployments only produce low sample rate aggregated data. In this paper, we examine the task of separating whole-home water consumption into its component appliances. A key challenge is to address the unique features of low sample rate data. To this end, we propose Sparse Coding with Featured Discriminative Dictionary (SCFDD) by incorporating inherent shape and activation features to capture the discriminative characteristics of devices. In addition, extensive experiments were performed to validate the effectiveness of SCFDD. C1 [Wang, Bingsheng; Chen, Feng; Dong, Haili; Lu, Chang-Tien] Virginia Tech, Falls Church, VA 22043 USA. [Boedihardjo, Arnold P.] US Army Corps Engn, Alexandria, VA 22315 USA. RP Wang, BS (reprint author), Virginia Tech, Falls Church, VA 22043 USA. EM claren89@vt.edu; chenf@vt.edu; hailid@vt.edu; arnold.p.boedihardjo@usace.army.mil; ctlu@vt.edu NR 22 TC 1 Z9 1 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-4786 BN 978-1-4673-4649-8; 978-0-7695-4905-7 J9 IEEE DATA MINING PY 2012 BP 1134 EP 1139 DI 10.1109/ICDM.2012.146 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA BEF30 UT WOS:000316383800137 ER PT B AU Houghton, PD Bowman, EK AF Houghton, Peter D. Bowman, Elizabeth K. BE Blasch, E Bosse, E Lambert, DA TI User-Defined Operating Picture (UDOP) SO HIGH-LEVEL INFORMATION FUSION MANAGEMENT AND SYSTEMS DESIGN SE Artech House Intelligence and Information Operations Series LA English DT Article; Book Chapter AB The concept of the user-defined operating picture (UDOP) has risen as a response to observed limitations of current military "picturing" capabilities in coping with today's and tomorrow's evolving operational needs. Many of these challenges can only be adequately addressed through the provision of a more flexible and end-user community driven capability; one which supports a more rapid and agile configuration of picturing systems. In this chapter, we discuss the nature of the challenges and how these affect current picturing systems. We describe what UDOP characteristics could address these challenges, and consider what could be done to realize a UDOP capability by exploiting understanding gained from the development of prototypical UDOP implementations. This chapter concludes with a discussion on a few of the remaining issues that need to be addressed before UDOP could become a reality. The discussion in this chapter is an expression of a current position with respect to the concepts and is intended to stimulate a discussion on the needs for and the nature of UDOP. C1 [Houghton, Peter D.] DSTL, Portsdown West PO17 6AD, Fareham, England. [Bowman, Elizabeth K.] USA, Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Houghton, PD (reprint author), DSTL, Portsdown West PO17 6AD, Fareham, England. EM PDHOUGHTON@mail.dstl.gov.uk; elizabeth.k.bowman.civ@mail.mil NR 25 TC 0 Z9 0 U1 0 U2 1 PU ARTECH HOUSE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 USA BN 978-1-60807-151-7 J9 ARTECH HSE INTEL INF PY 2012 BP 193 EP 213 PG 21 WC Computer Science, Information Systems SC Computer Science GA BEL07 UT WOS:000317148000009 ER PT S AU Allen, JL Jow, TR Wolfenstine, J AF Allen, J. L. Jow, T. R. Wolfenstine, J. BE Julien, CM Meng, S Zaghib, K Kanno, R TI LiCoPO4 as Li-ion Cathode SO INTERCALATION COMPOUNDS FOR RECHARGEA BLE BATTERIES SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Intercalation Compounds for Rechargeable Batteries held during the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc (ECS), Battery, Energy Technol AB LiCoPO4 as Li-ion cathode is attractive owing to its potentially high energy storage capability. Its adoption has been slowed owing to its poor cycle life. In this paper we present results of Fe-substitution of LiCoPO4 that improves its cycle life. We report on the nature of the substitution and the analysis of the substituted material both electrochemically and structurally. We have achieved up to 500 cycles with about 80% discharge capacity retention using an electrolyte additive to counter electrolyte degradation which would occur on this 4.8V Li-ion insertion cathode. C1 [Allen, J. L.; Jow, T. R.; Wolfenstine, J.] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RP Allen, JL (reprint author), USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. NR 7 TC 3 Z9 3 U1 0 U2 13 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-328-5; 978-1-56677-969-2 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 29 BP 15 EP 20 DI 10.1149/1.3696679 PG 6 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BEI36 UT WOS:000316695900003 ER PT S AU Turner, KL Burgner, CB Yie, Z Holtoff, E AF Turner, Kimberly L. Burgner, Christopher B. Yie, Zi Holtoff, Ellen GP IEEE TI Using Nonlinearity to Enhance Micro/NanoSensor Performance SO 2012 IEEE SENSORS PROCEEDINGS SE IEEE Sensors LA English DT Proceedings Paper CT 11th IEEE Sensors Conference CY OCT 28-31, 2012 CL Taipei, TAIWAN SP IEEE, Sensors Council, Sensirion, Natl Chiao Tung Univ, Nanotechnol & Micro Syst Assoc (NMA), Natl Cheng Kung Univ, Tsinghua Univ, Natl Sci Council, Bur Foreign Trade, Ind Technol Res Inst, Dept Informat & Tourism, Meet Taiwan, Clean Energy Technol (Ce Tech), Phison Elect Corp (PHISON), Everlight, Tong Hsing Elect Ind, Ltd, Natl Ctr High-Performance Comp (NCHC), Natl Appl Res Labs, Minist Foreign Affairs, Natl Program Nano Technol (NPNT) ID MOLECULARLY IMPRINTED POLYMERS; EXPLOSIVES; SENSOR; VAPOR AB Resonant microelectromechanical systems are key building blocks for many microsensor applications, including mass detection, inertial detection and RF filters and timing oscillators. Especially in systems with low damping, amplitudes are such that nonlinearities are present. In many applications, these nonlinearities can be significant, and need to be accounted for. In this paper, mass sensing of DNT will be discussed in the context of an application where understanding and cleverly utilizing nonlinearity results in improved sensor performance. C1 [Turner, Kimberly L.; Burgner, Christopher B.; Yie, Zi] UC Santa Barbara, Princeton, NJ 08540 USA. [Holtoff, Ellen] Sensors & Devices Directorate Adelphi, Army Res Lab, Adelphi, MD USA. RP Turner, KL (reprint author), UC Santa Barbara, Princeton, NJ 08540 USA. EM turner@engineering.ucsb.edu FU Institute for Collaborative Biotechnologies through U.S. Army Research Office [W911NF-09-0001] FX This work was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. NR 15 TC 2 Z9 2 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4577-1766-6; 978-1-4577-1765-9 J9 IEEE SENSOR PY 2012 BP 154 EP 157 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BDY72 UT WOS:000315671100039 ER PT S AU Edelstein, AS Petrie, JR Sreenivasulu, G Srinivasan, G Viehland, D Fang, J AF Edelstein, Alan S. Petrie, Jonathan R. Sreenivasulu, Gollapudi Srinivasan, Gopalan Viehland, Dwight Fang, Jie GP IEEE TI Magnetoelectric Sensors: Sensitive and Potentially Low-cost Magnetic Sensors SO 2012 IEEE SENSORS PROCEEDINGS SE IEEE Sensors LA English DT Proceedings Paper CT 11th IEEE Sensors Conference CY OCT 28-31, 2012 CL Taipei, TAIWAN SP IEEE, Sensors Council, Sensirion, Natl Chiao Tung Univ, Nanotechnol & Micro Syst Assoc (NMA), Natl Cheng Kung Univ, Tsinghua Univ, Natl Sci Council, Bur Foreign Trade, Ind Technol Res Inst, Dept Informat & Tourism, Meet Taiwan, Clean Energy Technol (Ce Tech), Phison Elect Corp (PHISON), Everlight, Tong Hsing Elect Ind, Ltd, Natl Ctr High-Performance Comp (NCHC), Natl Appl Res Labs, Minist Foreign Affairs, Natl Program Nano Technol (NPNT) ID ROOM-TEMPERATURE; MAGNETORESISTANCE AB The sensor element of magnetoelectric (ME) sensors generate an output with requiring an input energy. In addition they are relatively sensitive, but in common with most other magnetic sensors, their performance deteriorates at low frequency. We have found that, by applying an additional higher frequency, magnetic modulation field to ME sensors, we can increase the sensitivity by a factor of 10 at l Hz. When a modulation field is applied, the signal appears as sidebands around the modulation frequency. A further improvement can be achieved if one adjusts the modulation frequency so that the sideband occurs at the mechanical resonant frequency of the sensor. Using this modulation, ME sensors can detect 4 pT/root Hz at 1 Hz in an unshielded room. We have found that we can increase the resonant frequency of asymmetric ME sensors by using a weight to apply a restoring torque. These sensors can also detect acoustic disturbances. By sweeping a magnetic field at the same time one is applying either a magnetic or acoustic field, one can distinguish between acoustic and magnetic sources. C1 [Edelstein, Alan S.; Petrie, Jonathan R.] US Army, Res Lab, Adelphi, MD 20783 USA. [Sreenivasulu, Gollapudi; Srinivasan, Gopalan] Oakland Univ, Rochester, MI 48309 USA. [Viehland, Dwight; Fang, Jie] Virginia Tech, Blacksburg, VA 24061 USA. RP Edelstein, AS (reprint author), US Army, Res Lab, Adelphi, MD 20783 USA. EM alan.s.edelstein.civ@mail.mil FU project under the Defense Advanced Research Projects Agency ( DARPA) Uncooled Magnetic Sensor; Heterostructural Uncooled Magnetic Sensors ( HUMS) program FX The support for this project under the Defense Advanced Research Projects Agency ( DARPA) Uncooled Magnetic Sensor, Heterostructural Uncooled Magnetic Sensors ( HUMS) program is gratefully acknowledged. NR 7 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4577-1766-6; 978-1-4577-1765-9 J9 IEEE SENSOR PY 2012 BP 2098 EP 2100 PG 3 WC Engineering, Electrical & Electronic; Remote Sensing SC Engineering; Remote Sensing GA BDY72 UT WOS:000315671100502 ER PT B AU Shelton, D Salter, M Ridler, N Horibe, M AF Shelton, Dexter Salter, Martin Ridler, Nick Horibe, Masahiro GP IEEE TI Characterizing Artefact Standards for Use with Coaxial Vector Network Analyzers at Millimeter-wave Frequencies SO 80TH ARFTG MICROWAVE MEASUREMENT CONFERENCE: ADVANCES IN WIRELESS COMMUNICATIONS TEST AND MEASUREMENTS LA English DT Proceedings Paper CT 80th ARFTG Microwave Measurement Conference (ARFTG) - Advances in Wireless Communications Test and Measurements CY NOV 29-30, 2012 CL San Diego, CA SP IEEE, ARFTG, MTT-S DE Measurement standards; metrology; microwave measurements; millimeter wave measurements; transmission line measurements AB Traceability for vector network analyzer (VNA) measurements in coaxial lines smaller than 2.4 mm is problematic. The common method for traceability is to use precision coaxial air lines as primary standards. Since slotless lines are not commercially available in lines of this size, the air lines used are difficult to connect, extremely delicate, and expensive to replace. This paper describes a method of characterizing artefacts to use as standards, including specially designed and manufactured air-dielectric shielded open-circuits of various offset lengths as well as offset short-circuits and well-matched loads available in commercial VNA calibration kits. This will provide traceability using more robust and easier to use standards for calibration of the VNA. The proposed method is illustrated by measurement results obtained in 1.85 mm coaxial line (to 65 GHz.) C1 [Shelton, Dexter] USA, Primary Stand Lab, Redstone Arsenal, AL 59257 USA. [Shelton, Dexter; Salter, Martin; Ridler, Nick] Nat Phys Lab, Teddington, Middx, England. [Horibe, Masahiro] Nat Metrol Inst Japan, Tsukuba, Ibaraki, Japan. RP Shelton, D (reprint author), USA, Primary Stand Lab, Redstone Arsenal, AL 59257 USA. FU Industrial Technology Research from New Energy and Industrial Technology Development Organization ( NEDO) of Japan; Nation Measurement System Directorate of the UK government Department for Business, Innovation Skills; US Department of Defense Engineering and Scientist Exchange Program FX The work described in this paper was supported by: (i) the Industrial Technology Research Grant Program in 2009 from New Energy and Industrial Technology Development Organization ( NEDO) of Japan; ( ii) the Nation Measurement System Directorate of the UK government Department for Business, Innovation Skills; and ( iii) the US Department of Defense Engineering and Scientist Exchange Program NR 14 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-4820-1; 978-1-4673-4817-1 PY 2012 PG 6 WC Telecommunications SC Telecommunications GA BEJ81 UT WOS:000317004000008 ER PT S AU Farrell, ME Pellegrino, PM AF Farrell, Mikella E. Pellegrino, Paul M. BE Mohseni, H Agahi, MH Razeghi, M TI Army relevant Biological Hazards Detection with Commercial SERS substrates SO BIOSENSING AND NANOMEDICINE V SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Biosensing and Nanomedicine V CY AUG 12-15, 2012 CL San Diego, CA SP SPIE DE SERS; sensor; chemical; biological; Raman; detection; peptide; biomimetic; protective antigen; anthrax ID ENHANCED-RAMAN-SCATTERING; PROTEIN-KINASE ACTIVITY; BACILLUS-ANTHRACIS SPORES; SINGLE-MOLECULE; GOLD NANOPARTICLES; PROTECTIVE ANTIGEN; SILVER ELECTRODE; BACTERIAL-SPORES; LETHAL FACTOR; SPECTROSCOPY AB There is an increasing need and challenge for early rapid and accurate detection, identification, and quantification of chemical, biological, and energetic hazards in many fields of interest (e. g., medical, environmental, industrial, and defense applications). Increasingly to meet these challenges, researchers are turning to interdisciplinary approaches combining spectroscopy with nanoscale platforms to create technologies that offer viable and novel solutions for today's sensing needs. One technology that has gained increasing popularity to meet these needs is surface enhanced Raman scattering (SERS). SERS is particularly advantageous as it does not suffer from interferences from water, requires little to no sample preparation, is robust and can be used in numerous environments, is relatively insensitive to the wavelength of excitation employed and produces a narrow-band spectral signature unique to the molecular vibrations of the analyte. SERS enhancements (chemical and electromagnetic) are typically observed on metalized nanoscale roughened surfaces. For ideal SERS sensing, a commercially available uniform and reproducible nanoscale surface demonstrating high sensitivity are desirable. Additionally, if these surfaces can be modified for the selective sensing of hazard materials, an ideal sensor platform for dynamic in field measurements can be imagined. In this proceedings paper, preliminary efforts towards the characterization and application of commercially available next generation Klarite substrates will be demonstrated. Additionally, efforts toward chemical modification of these substrates, through peptide recognition elements, can be used for the targeted sensing of hazardous materials. C1 [Farrell, Mikella E.; Pellegrino, Paul M.] USA, Res Labs, RDRL SEE E, Adelphi, MD 20783 USA. RP Farrell, ME (reprint author), USA, Res Labs, RDRL SEE E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 102 TC 1 Z9 1 U1 1 U2 15 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9177-0 J9 PROC SPIE PY 2012 VL 8460 AR 84600J DI 10.1117/12.929873 PG 12 WC Engineering, Biomedical; Nanoscience & Nanotechnology; Optics SC Engineering; Science & Technology - Other Topics; Optics GA BEH80 UT WOS:000316633700004 ER PT J AU Nguyen, L Koenig, F AF Lam Nguyen Koenig, Francois BE Coquillart, S Feiner, S Kiyokawa, K TI Augmented Reality for Forward-Looking Synthetic Aperture Radar SO IEEE VIRTUAL REALITY CONFERENCE 2012 PROCEEDINGS LA English DT Proceedings Paper CT 19th IEEE Virtual Reality Conference CY MAR 04-08, 2012 CL Costa Mesa, CA SP IEEE, IEEE Comp Soc, IEEE Visualizat & Graph Techn Comm (VGTC) DE augmented reality; ultra wideband radar; synthetic aperture radar; forward-looking radar AB The U.S. Army Research Laboratory (ARL) has successfully designed and integrated an augmented reality system into our vehicle-based ultra wideband (UWB) forward-looking synthetic aperture radar (SAR). In this paper, we present the overall architecture of the system and results from our recent experiment. C1 [Lam Nguyen; Koenig, Francois] USA, Res Lab, Washington, DC 20310 USA. RP Nguyen, L (reprint author), USA, Res Lab, Washington, DC 20310 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-1246-2 PY 2012 BP 145 EP 146 PG 2 WC Computer Science, Cybernetics SC Computer Science GA BEJ84 UT WOS:000317006300061 ER PT S AU DeCuir, EA Gautam, N Meissner, GP Wijewarnasuriya, PS Krishna, S Dhar, NK Bramhall, TG Welser, RE Sood, AK AF DeCuir, Eric A., Jr. Gautam, Nutan Meissner, Gregory P. Wijewarnasuriya, Priyalal S. Krishna, Sanjay Dhar, Nibir K. Bramhall, Thomas G. Welser, Roger E. Sood, Ashok K. BE LeVan, PD Sood, AK Wijewarnasuriya, PS DSouza, AI TI Design and Development of Low Dark Current SLS Detectors for IRFPA Applications SO INFRARED SENSORS, DEVICES, AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Sensors, Devices, and Applications II CY AUG 14-15, 2012 CL San Diego, CA SP SPIE DE type II; InAs/GaSb superlattice; pBiBn; barrier; infrared; photodetectors ID SUPERLATTICES AB We present the performance of a unipolar barrier long-wave type-II InAs/GaSb superlattice (SLS) photodetector with a 50% cut-off wavelength of approximately 8.7 microns. In this study, the ability to lower dark current densities over traditional PIN diodes is presented by way of hetero-structure engineering of a pBiBn structure utilizing superlattice P-type (P) and N-type (N) contacts, Intrinsic (I) superlattice active (absorber) region, and unipolar superlattice electron and hole blocking (b) layers. The spectral response of this pBiBn detector structure was determined using a Fourier Transform Infrared (FTIR) Spectrometer and the quantum efficiency (QE) was determined using a narrow 6250 nm narrow band filter and a 500K blackbody source. A diode structure designed, grown, and fabricated in this study yielded a dark current density of less than one (1) mA/cm(2) at a reverse bias of 150 mV and a specific detectivity value of greater than 10(11) Jones at 77K. In addition to single point temperature measurements, a variable temperature study (80K-300K) of the dark current is presented for a diode demonstrating diffusion limited dark current from 160K down to 80K. C1 [DeCuir, Eric A., Jr.; Meissner, Gregory P.; Wijewarnasuriya, Priyalal S.] USA, Res Lab, Adelphi, MD 20783 USA. [Gautam, Nutan; Krishna, Sanjay] Univ New Mexico, Ctr High Tech Mat, Dept Elect & Comp Eng, Albuquerque, NM 87106 USA. [Dhar, Nibir K.] MTO, DARPA, Arlington, VA USA. [Bramhall, Thomas G.] US Army, AMSRD, Arsenal, AL USA. [Welser, Roger E.; Sood, Ashok K.] Magnolia Optic Technol, Inc, Woburn, MA 01801 USA. RP DeCuir, EA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM eric.a.decuir.civ@mail.mil NR 13 TC 1 Z9 1 U1 3 U2 6 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9229-6 J9 PROC SPIE PY 2012 VL 8512 AR 85120N DI 10.1117/12.974237 PG 7 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BEH87 UT WOS:000316636700015 ER PT S AU Sood, AK Pethuraja, G Sood, AW Welser, RE Puri, YR Cho, J Schubert, EF Dhar, NK Wijewarnasuriya, PS Soprano, MB AF Sood, Ashok K. Pethuraja, Gopal Sood, Adam W. Welser, Roger E. Puri, Yash R. Cho, Jaehee Schubert, E. Fred Dhar, Nibir K. Wijewarnasuriya, Priyalal S. Soprano, Martin B. BE LeVan, PD Sood, AK Wijewarnasuriya, PS DSouza, AI TI DEVELOPMENT OF LARGE AREA NANOSTRUCTURE ANTIREFLECTION COATINGS FOR EO/IR SENSOR APPLICATIONS SO INFRARED SENSORS, DEVICES, AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Sensors, Devices, and Applications II CY AUG 14-15, 2012 CL San Diego, CA SP SPIE ID LOW-REFRACTIVE-INDEX; TECHNOLOGY AB Electro-optical/infrared nanosensors are being developed for a variety of defense and commercial systems applications. One of the critical technologies that will enhance EO/IR sensor performance is the development of advanced antireflection coatings with both broadband and omnidirectional characteristics. In this paper, we review our latest work on high quality nanostructure-based antireflection structures, including recent efforts to deposit nanostructured antireflection coatings on large area substrates. Nanostructured antireflection coatings fabricated via oblique angle deposition are shown to enhance the optical transmission through transparent windows by minimizing broadband reflection losses to less than one percent, a substantial improvement over conventional thin-film antireflection coating technologies. Step-graded antireflection structures also exhibit excellent omnidirectional performance, and have recently been demonstrated on 3-inch diameter substrates. C1 [Sood, Ashok K.; Pethuraja, Gopal; Sood, Adam W.; Welser, Roger E.; Puri, Yash R.] Magnolia Opt Technol Inc, 52-B Cummings Pk,Suite 314, Woburn, MA 01801 USA. [Cho, Jaehee; Schubert, E. Fred] Rensselaer Polytechn Inst, Dept ECSE & Phys, Troy, NY 12180 USA. [Dhar, Nibir K.] MTO, DARPA, Arlington, VA USA. [Wijewarnasuriya, Priyalal S.] Army Res Lab, Adelphi, MD 20783 USA. [Soprano, Martin B.] US Army, DARPA Programs Off, AMSRD, Redstone Arsenal, AL USA. RP Sood, AK (reprint author), Magnolia Opt Technol Inc, 52-B Cummings Pk,Suite 314, Woburn, MA 01801 USA. EM aksood@magnoliaoptical.com RI Pethuraja, Gopal/D-9976-2015 OI Pethuraja, Gopal/0000-0001-9789-5645 NR 14 TC 0 Z9 0 U1 3 U2 12 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9229-6 J9 PROC SPIE PY 2012 VL 8512 AR 85120R DI 10.1117/12.974239 PG 9 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BEH87 UT WOS:000316636700019 ER PT S AU Steenbergen, EH Connelly, BC Metcalfe, GD Shen, H Wraback, M Lubyshev, D Qiu, Y Fastenau, JM Liu, AWK Elhamri, S Cellek, OO Zhang, YH AF Steenbergen, E. H. Connelly, B. C. Metcalfe, G. D. Shen, H. Wraback, M. Lubyshev, D. Qiu, Y. Fastenau, J. M. Liu, A. W. K. Elhamri, S. Cellek, O. O. Zhang, Y. -H. BE LeVan, PD Sood, AK Wijewarnasuriya, PS DSouza, AI TI Temperature-dependent minority carrier lifetimes of InAs/InAs1-xSbx type-II superlattices SO INFRARED SENSORS, DEVICES, AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Sensors, Devices, and Applications II CY AUG 14-15, 2012 CL San Diego, CA SP SPIE DE temperature-dependent; lifetime; photoluminescence; infrared; superlattice AB Temperature-dependent minority carrier lifetimes of InAs/InAs1-xSbx type-II superlattices are presented. The longest lifetime at 11 K is 504 +/- 40 ns and at 77 K is 412 +/- 25 ns. Samples with long periods and small wave function overlaps have both non-radiative and radiative recombination mechanisms apparent, with comparable contributions from both near 77 K, and radiative recombination dominating at low temperatures. Samples with short periods and large wave function overlaps have radiative recombination dominating from 10 K until similar to 200 K. The improved lifetimes observed will enable long minority carrier lifetime superlattices to be designed for high quantum efficiency, low dark current infrared detectors. C1 [Steenbergen, E. H.] USAF, Res Lab, AFRL RXAN, Wright Patterson AFB, OH 45433 USA. [Steenbergen, E. H.; Cellek, O. O.; Zhang, Y. -H.] Arizona State Univ, Sch Elect, Center Photon Innovat, Comp & Energy Engn, Tempe, AZ 85287 USA. [Connelly, B. C.; Metcalfe, G. D.; Shen, H.; Wraback, M.] U S Army Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Lubyshev, D.; Qiu, Y.; Fastenau, J. M.; Liu, A. W. K.] IQE Inc, Bethlehem, PA 18015 USA. [Elhamri, S.] Univ Dayton, Department Phys, Dayton, OH 45469 USA. RP Steenbergen, EH (reprint author), USAF, Res Lab, AFRL RXAN, Wright Patterson AFB, OH 45433 USA. EM Elizabeth.Steenbergen@wpafb.af.mil FU DOD Science Math And Research for Transformation; Science Foundation Arizon; ASU Graduate and Professional Student Association; MURI program; U. S. Army Research Office [W911NF-10-1-0524]; Air Force Office for Scientific Research [FA9550-10-1-0129]; Army Research Laboratory [W911NF-12-2-0019] FX EHS acknowledges graduate fellowships from the DOD Science Math And Research for Transformation, Science Foundation Arizona, Achievement Rewards for College Scientists, and the ASU Graduate and Professional Student Association. This work was also partially supported by a MURI program from the U. S. Army Research Office with the grant number W911NF-10-1-0524, and a program from the Air Force Office for Scientific Research with the grant number FA9550-10-1-0129. BCC acknowledges support by the Army Research Laboratory, accomplished under Cooperative Agreement Number W911NF-12-2-0019. NR 17 TC 5 Z9 5 U1 0 U2 11 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9229-6 J9 PROC SPIE PY 2012 VL 8512 AR 85120L DI 10.1117/12.930949 PG 8 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BEH87 UT WOS:000316636700014 ER PT S AU Uppal, PN AF Uppal, Parvez N. BE LeVan, PD Sood, AK Wijewarnasuriya, PS DSouza, AI TI LWIR(Long Wave Infrared) and Quantum Dot Research at the US Army Research Laboratory (ARL) SO INFRARED SENSORS, DEVICES, AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Sensors, Devices, and Applications II CY AUG 14-15, 2012 CL San Diego, CA SP SPIE DE Solar Cells; infrared detectors; minority carrier lifetimes; type II superlattices; quantum dots AB This paper reviews the work of several teams at ARL. In the quantum well arena we are developing bulk InAsSb material for LWIR detectors type for high performance focal plane array applications, so far we have observed that the minority carrier lifetimes in the type II SLS material have been short. Short lifetimes present a major barrier towards the realization of high performance focal plane arrays. This paper discusses photoluminescence observed in InAsSb materials and our observation that the bandgap bowing parameter is much bigger than earlier studies have shown, opening up the possibility that up to 12 micron wavelength cut-off can be achieved in InAsSb alloys. In the second section a summary of the work done by the III-V and IR device team is presented, the team is using quantum dots to enhance the efficiency of solar photovoltaic devices. We have discovered that doping the quantum dots is critical in enhancing the efficiency of the solar cells. C1 USA, RDRL SEE I, Res Lab, Adelphi, MD 20783 USA. RP Uppal, PN (reprint author), USA, RDRL SEE I, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 6 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9229-6 J9 PROC SPIE PY 2012 VL 8512 AR 851206 DI 10.1117/12.972460 PG 3 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BEH87 UT WOS:000316636700003 ER PT J AU Russell, K Shen, Q AF Russell, Kevin Shen, Qiong TI Revisiting Planar Four-Bar Precision Synthesis with Finite and Multiply-Separated Positions SO JOURNAL OF ADVANCED MECHANICAL DESIGN SYSTEMS AND MANUFACTURING LA English DT Article DE Four-Bar Linkage; Optimization; Motion Generation; Velocity ID ROCKER LINKAGES AB This work revisits the topic of planar four-bar precision synthesis to approximate prescribed coupler positions and velocities-a topic originally published by Schaefer and Kramer((1)). Here, more general equation systems are formulated that include crank and follower dyad vector loop equations as objective functions, derivatives of these equations as velocity constraints and inequality constraints for order defect elimination. C1 [Russell, Kevin] USA, Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. [Shen, Qiong] ASCO Power Technol, Power Control Syst Engn, Florham Pk, NJ 07932 USA. RP Russell, K (reprint author), USA, Res Dev & Engn Ctr, Armaments Engn & Technol Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevin.russell1@us.army.mil; john.shen@emerson.com NR 13 TC 1 Z9 1 U1 0 U2 1 PU JAPAN SOC MECHANICAL ENGINEERS PI TOKYO PA SHINANOMACHI-RENGAKAN BLDG., SHINANOMACHI 35, SHINJUKU-KU, TOKYO, 160-0016, JAPAN SN 1881-3054 J9 J ADV MECH DES SYST JI J. Adv. Mech. Des. Syst. Manuf. PY 2012 VL 6 IS 7 BP 1273 EP 1280 DI 10.1299/jamdsm.6.1273 PG 8 WC Engineering, Manufacturing; Engineering, Mechanical SC Engineering GA 112ES UT WOS:000316575700007 ER PT J AU Krawczyk, S AF Krawczyk, Scott TI Broken Soldiers: Serving as Public Bodies SO KEATS-SHELLEY JOURNAL LA English DT Article C1 US Mil Acad, West Point, NY 10996 USA. RP Krawczyk, S (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU KEATS-SHELLEY ASSOC AMER INC PI NEW YORK PA NEW YORK PUBLIC LIBRARY, RM 226, FIFTH AVE, 42ND ST, NEW YORK, NY 10018-2788 USA SN 0453-4387 J9 KEATS-SHELLEY J JI Keats-Shelley J. PY 2012 VL 61 BP 90 EP 102 PG 13 WC Poetry SC Literature GA 098OT UT WOS:000315559300014 ER PT S AU Pritchett, TM Ferry, MJ Shensky, W Mott, AG Liu, R Sun, WF AF Pritchett, Timothy M. Ferry, Michael J. Shensky, William, III Mott, Andrew G. Liu, Rui Sun, Wenfang BE Jakubiak, R Eich, M Nunzi, JM TI Measurement of excited-state absorption cross sections of a novel platinum complex in picosecond top-hat Z-scan experiments employing partially coherent beams SO OPTICAL PROCESSES IN ORGANIC MATERIALS AND NANOSTRUCTURES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Optical Processes in Organic Materials and Nanostructures CY AUG 12-15, 2012 CL San Diego, CA SP SPIE DE Z scan; reverse saturable absorption AB In top-hat Z scans that employ tunable sources such as optical parametric generators without line-narrowing gratings, the size of the aperture used to clip the beam may exceed the coherence length, and the variation with z of the transverse profile of the resulting partially coherent beam may differ significantly from that of a perfect top-hat beam. After a careful validation of our experimental set-up, we perform picosecond open-aperture Z scans with a top-hat beam at selected wavelengths in the visible and nanosecond open-aperture Z scans with a spatially Gaussian beam at 532-nm wavelength on a toluene solution of a particular platinum(II) 2,2'-bipyridyl complex bearing naphthalimidylethynyl-substituted fluorenylacetylide ligands. We report values of the singlet and triplet excited-state absorption cross sections of the complex. C1 [Pritchett, Timothy M.; Ferry, Michael J.; Shensky, William, III; Mott, Andrew G.] USA, Res Lab, Attn RDRL SEE M, Adelphi, MD 20783 USA. RP Pritchett, TM (reprint author), USA, Res Lab, Attn RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM timothy.m.pritchett.civ@mail.mil RI Shensky, William/J-7012-2014 NR 10 TC 0 Z9 0 U1 1 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9191-6 J9 PROC SPIE PY 2012 VL 8474 AR 847404 DI 10.1117/12.928852 PG 9 WC Nanoscience & Nanotechnology; Optics SC Science & Technology - Other Topics; Optics GA BEE08 UT WOS:000316252100002 ER PT S AU Meyer, CD Bedair, SS Trocchia, SM Mirabelli, MA Benard, WL Ivanov, TG Boteler, LM AF Meyer, C. D. Bedair, S. S. Trocchia, S. M. Mirabelli, M. A. Benard, W. L. Ivanov, T. G. Boteler, L. M. BE Roozeboom, F Kakushima, K Iwai, H Timans, PJ Narayanan, V Kwong, DL Gusev, EP TI Heterogeneous Chip Integration into Silicon Templates by Through-Wafer Copper Electroplating SO SILICON COMPATIBLE MATERIALS, PROCESSES, AND TECHNOLOGIES FOR ADVANCED INTEGRATED CIRCUITS AND EMERGING APPLICATIONS 2 SE ECS Transactions LA English DT Proceedings Paper CT 2nd International Symposium on Silicon Compatible Materials, Processes, and Technologies for Advanced Integrated Circuits and Emerging Applications held as a part of the 221st Meeting of the Electrochemical-Society CY MAY 06-10, 2012 CL Seattle, WA SP Electrochem Soc (ECS), Electrochem Soc (ECS), Elect and Photon Div, Electrochem Soc (ECS), Dielectr Sci and Technol Div, Air Liquide, ASM Int, Centrotherm, IBM, Mattson Technol, Qualcomm, Sigma-Aldrich ID MODULE AB This work presents a strategy to enable heterogeneous integration by using electroplated copper as an embedding material to mechanically secure disparate electronic chips within a silicon template wafer. Manual placement of chips into template sockets yielded positional accuracy with <40 mu m offset. Temporary facedown attachment of template and chips to a backing surface was utilized to achieve surface planarity with <10 mu m topography. The surface of the resulting embedded wafer would be suitable for post-processing to realize interconnects. C1 [Meyer, C. D.; Bedair, S. S.; Trocchia, S. M.; Mirabelli, M. A.; Benard, W. L.; Ivanov, T. G.; Boteler, L. M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Meyer, CD (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 10 TC 4 Z9 4 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-316-2 J9 ECS TRANSACTIONS PY 2012 VL 45 IS 6 BP 163 EP 169 DI 10.1149/1.3700949 PG 7 WC Electrochemistry; Engineering, Electrical & Electronic SC Electrochemistry; Engineering GA BEJ35 UT WOS:000316883400017 ER PT S AU Tompkins, RP Smith, JR Zhou, S Kirchner, KW Derenge, MA Jones, KA Leach, JH Mulholland, G Udwary, K Preble, E Suvarna, P Tungare, M Shahedipour-Sandvik, F AF Tompkins, R. P. Smith, J. R. Zhou, S. Kirchner, K. W. Derenge, M. A. Jones, K. A. Leach, J. H. Mulholland, G. Udwary, K. Preble, E. Suvarna, P. Tungare, M. Shahedipour-Sandvik, F. BE Stokes, EB Hunter, GW Mi, Z Horng, RH Karim, Z ODwyer, C TI GaN Power Schottky Diodes SO WIDE-BANDGAP SEMICONDUCTOR MATERIALS AND DEVICES 13 SE ECS Transactions LA English DT Proceedings Paper CT 13th Symposium on Wide Bandgap Semiconductor Materials and Devices held during the 221st Meeting of the Electrochemical-Society CY MAY 06-10, 2012 CL Seattle, WA SP Electrochem Soc (ECS), ECS, Elect & Photon Div, Dielectr Sci & Technol Div, Sensor Div ID CARBON AB Metalorganic Chemical Vapor Deposition (MOCVD) GaN films were grown simultaneously on multiple substrates ranging in threading dislocation density from 10(3) to 10(10) cm(-2). GaN power Schottky diodes were fabricated on these films to examine the role of crystalline defects on the performance of these devices. For films grown on each of the four substrates, the breakdown voltages did not approach the theoretical limit of approximate to 1600 V. This was an unexpected result, in particular for films grown on the truly bulk GaN which demonstrated superior crystallinity as indicated by x-ray diffraction. We speculate that point defects, possibly carbon, are playing a role in the performance of these devices. C1 [Tompkins, R. P.; Smith, J. R.; Zhou, S.; Kirchner, K. W.; Derenge, M. A.; Jones, K. A.] USA, Res Lab, Sensor & Elect Devices Directorate, Adelphi, MD 20783 USA. [Leach, J. H.; Mulholland, G.; Udwary, K.; Preble, E.] Kyma Technol, Raleigh, NC 27617 USA. [Suvarna, P.; Shahedipour-Sandvik, F.] Univ Albany, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA. RP Tompkins, RP (reprint author), USA, Res Lab, Sensor & Elect Devices Directorate, Adelphi, MD 20783 USA. OI Smith, Joshua/0000-0002-3137-7180 FU U.S. Army Research Laboratory Postdoctoral Fellowship Program; Oak Ridge Associated Universities; U.S. Army Research Laboratory FX This work was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 7 TC 0 Z9 0 U1 0 U2 8 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-317-9; 978-1-56677-959-3 J9 ECS TRANSACTIONS PY 2012 VL 45 IS 7 BP 17 EP 25 DI 10.1149/1.3701521 PG 9 WC Electrochemistry; Engineering, Electrical & Electronic SC Electrochemistry; Engineering GA BEI25 UT WOS:000316687500003 ER PT B AU Birkemeier, WA Jensen, RE Bernard, LJ Bouchard, R AF Birkemeier, William A. Jensen, Robert E. Bernard, Landry J. Bouchard, Richard GP IEEE TI IOOS Wave Observations, a National Perspective SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc, IEEE Ocean Engn Soc DE waves; observations; models; climate; IOOS AB The 2009 National Operational Wave Observation Plan is being updated in 2012 to reflect the present state of the wave observation network and revised to better define priority placements and upgrades, and to identify the stations with the longest data records. The revised plan, which is based on the existing 200 locations, defines a perimeter Backbone network of observing sites and proposes adding 47 new locations and upgrading the directional wave measurement of 87 stations. 10 Rover Buoys are recommended to be used with one year deployments to evaluate regional wave models so that they can be used as virtual wave gauges. The plan also identifies 60 of the existing US backbone locations with record lengths of 20 years or longer (the longest record is 38 years). These Sentinel Stations are critical to understanding climatic changes to the Nation's wave conditions. In this paper, we review the status of the nation's wave observation network, present a number of proposed changes and describe a process using wave models and short-term wave sensor deployments to optimize the wave observations in a particular region. C1 [Birkemeier, William A.; Jensen, Robert E.] ERDC CHL, Vicksburg, MS 39180 USA. [Bernard, Landry J.; Bouchard, Richard] NOAA, Natl Data Buoy Ctr, Stennis Space Ctr, MS USA. RP Birkemeier, WA (reprint author), ERDC CHL, Vicksburg, MS 39180 USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8; 978-1-4673-0830-4 PY 2012 PG 8 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300269 ER PT J AU Brodie, KL Slocum, RK McNinch, JE AF Brodie, Kate L. Slocum, Richard K. McNinch, Jesse E. GP IEEE TI New Insights into the Physical Drivers of Wave Runup from a Continuously Operating Terrestrial Laser Scanner SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc (MTS), IEEE OES (IEEE/OES) DE Runup; Lidar; Foreshore Morphology; Swash Zone; Tide ID NATURAL BEACH; SWASH; SETUP; ZONE AB A dune-mounted terrestrial laser scanner was used to investigate the physical drivers of runup on an intermediate beach under a variety of wave conditions. Specifically, the laser is automated to collect hourly, simultaneous observations of beach morphology and hydrodynamics in the swash and inner surf-zone. A strong tidal signal in de-tided runup statistics is observed such that the 2% exceedence runup elevation and mean swash elevation is higher at high tide than at low tide for the same given wave conditions. This is similar to the significant incident band wave height (Hsin) at the base of the foreshore, which also showed a similar strong tidal dependence. In fact, our results suggest that mean swash elevation and incident band swash scale well with Hsin, though correlations are slightly improved when beach foreshore slope is included in predictions of incident band swash (r(2) = 0.73 vs 0.69). In contrast, the Stockdon et al., 2006 relationship, which is based on beach foreshore slope, offshore wave height, and wavelength, only explained 53% of the variance in our data even when beach slope was known. Similar to Stockdon et al., we found infragravity band swash was dependent on deep water wave height and wave length. These data suggest that increased or decreased breaking over the sandbar at low and high tides, respectively, may filter the amount of energy left in the incident band to be transferred to runup at the shoreline. The implications of this sandbar filtering are that up-to-date bathymetry or a quantification of dissipation across the surf-zone is necessary to produce accurate real-time runup predictions. C1 [Brodie, Kate L.; Slocum, Richard K.; McNinch, Jesse E.] USACE Field Res Facil, Duck, NC 27949 USA. RP Brodie, KL (reprint author), USACE Field Res Facil, 1261 Duck Rd, Duck, NC 27949 USA. EM Katherine.L.Brodie@usace.army.mil NR 23 TC 0 Z9 0 U1 0 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8 PY 2012 PG 8 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300173 ER PT B AU Forte, MF Hanson, JL Hagerman, G AF Forte, Michael F. Hanson, Jeffrey L. Hagerman, George GP IEEE TI NORTH ATLANTIC WIND AND WAVE CLIMATE: OBSERVED EXTREMES, HINDCAST PERFORMANCE, AND EXTRATROPICAL RECURRENCE INTERVALS SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc, IEEE Ocean Engn Soc AB An investigation of the extreme offshore wind and wave climate in the mid-Atlantic region has been conducted for the U.S. Bureau of Safety and Environmental Enforcement (BSEE). The overall objective of the project is to assist with the development of Metocean standards for offshore wind farm design, and establish a 100-yr extratropical wind speed and wave height climatology for the specific regions of interest. Specific accomplishments include evaluating and selecting a climatological data base to use for the study, establish a technique for performing the extremal analysis, and generating maps of 100-yr return period wind speeds and wave heights. Measured data from National Data Buoy Center (NDBC) and Scripps Coastal Data Information Program (CDIP) offshore stations were used to characterize the storm climate and to assess the strengths and weaknesses of two North Atlantic Ocean hindcasts. Hindcasts under consideration included the 20-yr USACE Wave Information Studies (WIS) with kinematically adjusted storm winds, and a new 30-yr WAVEWATCH III (R) hindcast using National Centers for Environmental Prediction (NCEP) Climate Forecast System Reanalysis Reforecast (CFSRR) winds. Using the latest available techniques for wave spectral partitioning, a sea and swell climatology for the region is presented. Robust error metrics quantify hindcast performance in replicating both the observed wave systems and event peak conditions. Each hindcast product was found to have specific strengths and weaknesses. Although the WIS hindcast is shown to have superior winds, the WIS and NCEP wave hindcast results are mixed. As the NCEP product is presently only available for research purposes, the WIS hindcast was selected for use in computation of the final map products. A total of four extremal analysis techniques were evaluated for assessment of extratropical wind and wave storm data. The Empirical Simulation Technique (EST) provided in [14] employs a life-cycle approach to extreme value analysis. In contrast, the Generalized Pareto Distribution (GPD) [2], Weibull [11], and Generalized Extreme Value (GEV) [22] methods are parametric extrapolations to the data. To evaluate these approaches in our area of interest, extratropical Storm populations were identified at five test stations by applying both Peak over Threshold (POT) and Annual Maximum Series (AMS) techniques (for use with the GEV) to the NCEP 30-yr hindcast which is the longest hindcast currently available. Tropical storms were removed by an automated process linked to the North Atlantic Hurricane Database (HURDAT). The four extremal techniques were applied to the storm populations and comparisons made at the 50- and 100-yr recurrence interval. The selection of a final methodology will be described and resulting maps of the 50- and 100-yr recurrence interval extratropical wind speeds and wave heights will be presented. C1 [Forte, Michael F.; Hanson, Jeffrey L.; Hagerman, George] USA, Corps Engineers, Field Res Facil, Duck, NC 27949 USA. RP Forte, MF (reprint author), USA, Corps Engineers, Field Res Facil, Duck, NC 27949 USA. EM Michael.F.Forte@usace.army.mil NR 21 TC 0 Z9 0 U1 1 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8; 978-1-4673-0830-4 PY 2012 PG 10 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300047 ER PT J AU Freer, DA Scarborough, B Pipes, J AF Freer, Daniel A. Scarborough, Brian Pipes, Jason GP IEEE TI FIELDING A CROSS SHORE ARRAY OF GAGES IN AN ENERGETIC COASTAL ENVIRONMENT SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc (MTS), IEEE OES (IEEE/OES) AB with decades of experience deploying and recovering gages in the near shore coastal environment we have learned a thing or two about what works and what doesn't. Capturing some of this technical knowledge here may be useful to those working in or planning instrument deployments in the challenging surf zone and cross shore areas. Both the working techniques and some of the failed attempts will be shared for the benefit, and entertainment, of those interested in the challenges of these areas. Techniques employed to obtain deployment durations of up to 6 years will be discussed, as well as, the basic working components or practical aspects, which will be presented in topics such as; Survey Techniques, Instrument Mounts, Pipes and Pods, Antifouling Techniques, Cables and Splices, Deployment Vessels, Diver Operations, Troubleshooting and Fault Isolation. Up-close pre and post deployment pictures and even vendor information will give a real nuts and bolts look at the deployment techniques. Years of experience have given us some knowledge, but if we don't share it, it stays in peoples' heads and goes away with them. It is the authors' hope that an ongoing information exchange or working group will be established for the mutual benefit of those interested. This way the knowledge that is out there can be passed on. C1 [Freer, Daniel A.; Scarborough, Brian; Pipes, Jason] USA, Corps Engineers, Field Res Facil, Duck, NC USA. RP Freer, DA (reprint author), USA, Corps Engineers, Field Res Facil, Duck, NC USA. EM Dan.Freer@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8 PY 2012 PG 8 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300117 ER PT B AU Howlett, E Wilcox, K Crosby, A Bird, A Signell, R Graves, S Maskey, M Keiser, K Smith, L Wright, D Luettich, R Hanson, J Baltes, R AF Howlett, Eoin Wilcox, Kyle Crosby, Alex Bird, Andrew Signell, Richard Graves, Sara Maskey, Manil Keiser, Ken Smith, Liz Wright, Don Luettich, Rick Hanson, Jeff Baltes, Rebecca GP IEEE TI The US IOOS Coastal and Ocean Modeling Testbed for Advancing Research to Applications SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc, IEEE Ocean Engn Soc AB Coastal waters and lowlands of the U. S. are threatened by climate change, sea-level rise, flooding, oxygen depleted "dead zones", oil spills and unforeseen disasters. With funding from U. S. Integrated Ocean Observing System (IOOS (R)), the Southeast University Research Association (SURA) facilitated strong and strategic collaborations among experts from academia, federal operational centers and industry and guided the U. S. IOOS Coastal and Ocean Modeling Testbed (COMT) through its successful pilot phase. The focus of this paper is the development of the cyberinfrastructure, including successes and challenges during this pilot phase of the COMT. This is the first testbed intended to serve multiple federal agencies and be focused on the coastal ocean and Great Lakes. National Oceanic and Atmospheric Administration's (NOAA) National Center for Environmental Prediction (NCEP) has offered an operational base for the COMT, which addresses NCEP modeling challenges in coastal predictions by enabling the transition of research improvements into NCEP's operational forecast capability. Additional Federal participants include Navy, U. S. Geological Survey (USGS), Environmental Protection Agency and the U. S. Army Corps of Engineers (USACE). The mission of the Coastal and Ocean Modeling Testbed (COMT) is to use targeted research and development to accelerate the transition of scientific and technical advances from the coastal and ocean modeling research community to improve identified operational ocean products and services (i.e. via research to applications and also applications to research). The vision of the program is to enhance the accuracy, reliability, and scope of the federal suite of operational ocean modeling products, while ensuring its user community is better equipped to solve challenging coastal problems and recognize the COMT to be where the best coastal science is operationalized. Since its initiation in June, 2010, the COMT has developed to include a flexible and extensible community research framework to test and evaluate predictive models to address key coastal environmental issues. Initially, the COMT addressed three general research challenges of socioeconomic relevance: estuarine hypoxia, shelf hypoxia, and coastal inundation. A cyberinfrastructure was developed to facilitate model assessment based on community standards, including a distributed data repository, automated cataloging mechanism, quick browse facility, and tools for flexible and detailed scientific investigation of both model output and data. Models, tools and techniques from the Testbed are starting to be incorporated into the NOAA research and operational frameworks, reducing the transition time from research to federal operations. Ultimately, the COMT has had many successes as a pilot project and provides an effective and efficient environment for coordinating and improving coastal ocean and Great Lakes modeling efforts needed by the federal operational forecasting community. C1 [Howlett, Eoin; Wilcox, Kyle; Crosby, Alex; Bird, Andrew] Appl Sci Associates, S Kingstown, RI 02879 USA. [Signell, Richard] US Geol Survey, Woods Hole, MA USA. [Graves, Sara; Maskey, Manil; Keiser, Ken] Univ Alabama, Huntsville, AL 35899 USA. [Smith, Liz; Wright, Don] Southeastern Univ Res Assoc, Washington, DC USA. [Luettich, Rick] Univ N Carolina, Chapel Hill, NC USA. [Hanson, Jeff] US Army Corps Engn, Duck, NC USA. [Baltes, Rebecca] US IOOS, Silver Spring, MD USA. RP Howlett, E (reprint author), Appl Sci Associates, S Kingstown, RI 02879 USA. NR 24 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8; 978-1-4673-0830-4 PY 2012 PG 7 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300185 ER PT J AU McNinch, JE Brodie, KL Slocum, RK AF McNinch, Jesse E. Brodie, Kate L. Slocum, Richard K. GP IEEE TI Radar Inlet Observing System (RIOS): Continuous Remote Sensing of Waves, Currents, and Bathymetry at Tidal Inlets SO 2012 OCEANS LA English DT Proceedings Paper CT MTS/IEEE Oceans Conference CY OCT 14-19, 2012 CL Virginia Beach, VA SP IEEE, Marine Technol Soc (MTS), IEEE OES (IEEE/OES) DE ebb tidal delta; tidal inlets; X-band radar ID NEARSHORE BAR BEHAVIOR; VIDEO OBSERVATIONS; MORPHOLOGY; IMAGERY; QUANTIFICATION; VARIABILITY; BEACH AB Radar Inlet Observing System (RIOS) remotely senses waves, currents, and bathymetry at tidal inlets and river mouths. RIOS utilizes a 25kW X-band, coherent-on-receive radar to measure wave parameters at 3m resolution up to 3km radius from the antenna. Data acquisition and processing are fully automated and capable of hourly observations and web posting from a small, mobile trailer. Wave shoaling and breaking, obtained from the time series of radar spikes generated by the roughened surface of waves, are used to infer water depths and identify the position of shoals and channels. The ability of RIOS to measure wave orbital velocities (radial components) in order to determine mean surface currents is also investigated. Results from a field experiment at New River Inlet, North Carolina in April-May 2012 indicate RIOS accurately characterized the location and morphology of shoals and channels across the ebb tidal delta over a range of quiescent and storm conditions. The magnitude of RIOS-measured surface currents were substantially less than in-situ observations and showed great sensitivity to sea surface roughness. C1 [McNinch, Jesse E.; Brodie, Kate L.; Slocum, Richard K.] USACE Field Res Facil, Duck, NC 27949 USA. RP McNinch, JE (reprint author), USACE Field Res Facil, 1261 Duck Rd, Duck, NC 27949 USA. EM Jesse.Mcninch@usace.army.mil NR 25 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0829-8 PY 2012 PG 8 WC Engineering, Multidisciplinary; Telecommunications SC Engineering; Telecommunications GA BDW56 UT WOS:000315350300175 ER PT S AU von Cresce, A Xu, K AF von Cresce, Arthur Xu, Kang BE Sunkara, MK Smart, MC Bugga, RV Abraham, KM Brodd, R TI Phosphate-Based Compounds as Additives for 5-Volt Lithium Ion Electrolytes SO RECHARGEABLE LITHIUM AND LITHIUM ION BATTERIES SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Rechargeable Lithium and Lithium Ion Batteries Held During the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc (ECS), Battery AB We have shown in previous work that fluorinated phosphate esters make effective additives to the standard carbonate-based electrolyte used in commercial and experimental Li-ion batteries. New results indicate that the degree of fluorination seems to have an effect on the performance of these additives in helping the full cell retain capacity during cycling tests. Experimental evidence gathered from half cell and full cell data lead us to hypothesize that fluorinated phosphate esters are participating in the formation of a tougher, more redox-resistant solid electrolyte interphase layer on both anode and cathode. Therefore, we propose a network-forming mechanism in which fluorinated phosphate esters function to protect the electrolytes from the electrodes in our tested Li-ion battery systems. C1 [von Cresce, Arthur; Xu, Kang] USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RP von Cresce, A (reprint author), USA, Electrochem Branch, Res Lab, Adelphi, MD 20783 USA. RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 NR 2 TC 1 Z9 1 U1 3 U2 17 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-342-1 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 41 BP 17 EP 22 DI 10.1149/1.4717958 PG 6 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BEC01 UT WOS:000316050800003 ER PT S AU Xu, K Oh, D Yi, H Qi, JF Xu, A Snyder, J Belcher, AM AF Xu, Kang Oh, Dahyun Yi, Hyunjung Qi, Jifa Xu, Alice Snyder, James Belcher, Angela M. BE Sunkara, MK Smart, MC Bugga, RV Abraham, KM Brodd, R TI Genetically Programming Interfaces between Active Materials, Conductive Pathway and Current Collector in Li Ion Batteries SO RECHARGEABLE LITHIUM AND LITHIUM ION BATTERIES SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Rechargeable Lithium and Lithium Ion Batteries Held During the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc (ECS), Battery ID VIRUS; ELECTRODES AB In this work we genetically programmed the M13 virus, so that the new clone expressed multifunctional coat protein sequences that selectively bind to designated surfaces and species. Using these new clones, composite network consisting of ironphosphate nanowire (a-FePO4) and single wall carbon nanotubes were self-assembled onto aluminum surfaces. Spectroscopic and electrochemical characterizations confirmed the 3D-structure as well as the electrochemical activity of such composite nanowires. C1 [Xu, Kang; Xu, Alice] USA, Sensor & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Oh, Dahyun; Yi, Hyunjung; Belcher, Angela M.] MIT, Dept Mat Sci & Engn, Cambridge, MA USA. [Snyder, James] US Army Res Lab, Weapon Mat Res Directorate, Aberdeen Proving Ground, MD 21001 USA. [Belcher, Angela M.] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. [Belcher, Angela M.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA. RP Xu, K (reprint author), USA, Sensor & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. FU Science and Engineering Apprentice Program ( SEAP); George Washington University; SEM training FX financial assistance from Science and Engineering Apprentice Program ( SEAP) administered by George Washington University and SEM training from Dr. Matthew Ervin at ARL. NR 10 TC 1 Z9 1 U1 1 U2 9 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-342-1; 978-1-56677-983-8 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 41 BP 55 EP 64 DI 10.1149/1.4717963 PG 10 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BEC01 UT WOS:000316050800008 ER PT S AU Behl, WK Read, JA AF Behl, Wishvender K. Read, Jeffrey A. BE Sunkara, MK Smart, MC Bugga, RV Abraham, KM Brodd, R TI A Study of Cobalt and Manganese Fluorides as Cathode Materials for Rechargeable Lithium Cells SO RECHARGEABLE LITHIUM AND LITHIUM ION BATTERIES SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Rechargeable Lithium and Lithium Ion Batteries Held During the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc (ECS), Battery ID NANOCOMPOSITES AB This paper describes a study of the lithium/transition metal fluoride cells using nanocomposites of carbon with cobalt or manganese fluorides as cathode materials. The nanocomposite cathode materials were prepared by high energy milling of carbon and metal fluorides. It was, however, found that cobalt trifluoride reacted with carbon during the high energy milling process to form carbon fluoride. The Li/cobalt fluoride cells were, therefore, studied by using nanocomposite cathodes prepared by high energy milling of carbon, cobalt metal and lithium fluoride or cathodes prepared by mixing carbon and cobalt trifluoride without subjecting the mixture to the high energy milling process. The charge-discharge characteristics of lithium/transition metal fluoride cells were studied at 22 degrees C and 50 degrees C using a 1M LiPF6-sulfolane solution as the electrolyte. The cells were found to be electrochemically reversible but could not be completely charged due to simultaneous oxidation of the electrolyte at potentials above similar to 4.5 Volts. C1 [Behl, Wishvender K.; Read, Jeffrey A.] USA, Res Lab, Adelphi, MD 20783 USA. RP Behl, WK (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 11 TC 3 Z9 3 U1 2 U2 15 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-342-1 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 41 BP 97 EP 106 DI 10.1149/1.4717967 PG 10 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BEC01 UT WOS:000316050800012 ER PT S AU Ho, J Xu, K AF Ho, Janet Xu, Kang BE Sunkara, MK Smart, MC Bugga, RV Abraham, KM Brodd, R TI Tailoring a Desired Interphase on Graphitic Anode SO RECHARGEABLE LITHIUM AND LITHIUM ION BATTERIES SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Rechargeable Lithium and Lithium Ion Batteries Held During the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc (ECS), Battery ID NATURAL GRAPHITE; ION BATTERIES; ELECTROLYTE; INTERFACE AB In this work we attempted to tailor the chemistry at edge sites of graphite by metallic decoration, so that Li+-transport at these key locations could be accelerated to benefit a fast-charging graphitic anode. C1 [Ho, Janet; Xu, Kang] USA, Res Lab, Adelphi, MD 20783 USA. RP Ho, J (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 11 TC 0 Z9 0 U1 0 U2 2 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-342-1 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 41 BP 159 EP 166 DI 10.1149/1.4717973 PG 8 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BEC01 UT WOS:000316050800018 ER PT S AU Xu, K von Cresce, A AF Xu, Kang von Cresce, Arthur BE Sunkara, MK Smart, MC Bugga, RV Abraham, KM Brodd, R TI Li+-Solvation Structure Directs Interphasial Processes on Graphitic Anodes SO RECHARGEABLE LITHIUM AND LITHIUM ION BATTERIES SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Rechargeable Lithium and Lithium Ion Batteries Held During the 220th Meeting of the Electrochemical-Society (ECS) CY OCT 09-14, 2011 CL Boston, MA SP Electrochem Soc (ECS), Battery ID ORGANIC ELECTROLYTE-SOLUTIONS; IONIZATION-MASS-SPECTROSCOPY; GRAPHITE/ELECTROLYTE INTERFACE; NONAQUEOUS ELECTROLYTES; LITHIUM IONS; SHEATH AB Using a mass spectrum technique and an "SEI-marker", we successfully established a direct link between Li+-solvation sheath structure and the interphasial processes occurring at graphitic anode. C1 [Xu, Kang; von Cresce, Arthur] USA, Electrochem Branch, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Electrochem Branch, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RI Cresce, Arthur/K-3958-2013 OI Cresce, Arthur/0000-0002-3894-6083 NR 11 TC 1 Z9 1 U1 0 U2 9 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-342-1 J9 ECS TRANSACTIONS PY 2012 VL 41 IS 41 BP 187 EP 193 DI 10.1149/1.4717976 PG 7 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BEC01 UT WOS:000316050800021 ER PT J AU McCormack, VJ AF McCormack, Valerie J. BE Douglass, JG Gonlin, N TI Fluctuating Community Organization Formation and Dissolution of Multifamily Corporate Groups at La Joya, Veracruz, Mexico SO ANCIENT HOUSEHOLDS OF THE AMERICAS: CONCEPTUALIZING WHAT HOUSEHOLDS DO LA English DT Article; Book Chapter ID SOUTHERN VERACRUZ; HOUSEHOLDS; VILLAGE; WEALTH C1 USA, Corps Engineers, Washington, DC USA. RP McCormack, VJ (reprint author), USA, Corps Engineers, Washington, DC USA. EM Valerie.J.McCormack@usace.army.mil NR 54 TC 3 Z9 3 U1 0 U2 2 PU UNIV PRESS COLORADO PI BOULDER PA 5589 ARAPAHOE AVE, STE 206C, BOULDER, CO 80303 USA BN 978-1-60732-173-6 PY 2012 BP 325 EP 352 PG 28 WC Anthropology SC Anthropology GA BDV80 UT WOS:000315209200012 ER PT B AU Wei, H Yadegar, J Salemann, L de la Cruz, J Gonzalez, HJ AF Wei, Hai Yadegar, Joseph Salemann, Leo de la Cruz, Julio Gonzalez, Hector J. GP IEEE TI A NOVEL CONTENT-ADAPTIVE IMAGE COMPRESSION SYSTEM SO 2012 IEEE VISUAL COMMUNICATIONS AND IMAGE PROCESSING (VCIP) LA English DT Proceedings Paper CT IEEE Visual Communications and Image Processing (VCIP) CY NOV 27-30, 2012 CL San Diego, CA SP IEEE, Qualcomm, Microsoft, Inter Digital, USC, Viterbi Sch Engn, IBM Res DE Image compression; compressed-domain analysis; pattern-driven model; classification ID MODEL AB This paper presents a novel content-adaptive image compression system. Utilizing a pattern-driven model, we explore the synergy between content-based analysis and compression. For a given image, disparate low-level visual patterns are automatically separated, modeled, and encoded using compact and "customized" features and parameters. The feasibility and efficiency of the proposed system were corroborated by quantitative experiments and comparisons. Since different patterns are separated and modeled explicitly during the compression, our method holds potentials for providing better support for compressed-domain analysis. C1 [Wei, Hai; Yadegar, Joseph] UtopiaCompression Corp, Los Angeles, CA USA. [Salemann, Leo] Lockheed Martin, Los Angeles, CA USA. [de la Cruz, Julio; Gonzalez, Hector J.] US Army, RDECOM, Los Angeles, CA USA. RP Wei, H (reprint author), UtopiaCompression Corp, Los Angeles, CA USA. FU U. S. Army SBIR program [W91CRB- 09- C0105] FX The work presented in this paper is partially supported under a U. S. Army SBIR program ( No. W91CRB- 09- C0105). NR 18 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-4405-0; 978-1-4673-4406-7 PY 2012 PG 6 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Imaging Science & Photographic Technology SC Computer Science; Engineering; Imaging Science & Photographic Technology GA BDW86 UT WOS:000315440800078 ER PT S AU O'Brien, H Ogunniyi, A Scozzie, C Shaheen, W Cheng, L Agarwal, A Francois, M Temple, V AF O'Brien, Heather Ogunniyi, Aderinto Scozzie, Charles Shaheen, William Cheng, Lin Agarwal, Anant Francois, Michel Temple, Victor GP IEEE TI Novel Packaging and High-Current Pulse-Switching of 1.0 cm(2) SiC SGTOs SO 2012 LESTER EASTMAN CONFERENCE ON HIGH PERFORMANCE DEVICES (LEC) SE Proceedings IEEE Lester Eastman Conference on High Performance Devices LA English DT Proceedings Paper CT IEEE Lester Eastman Conference on High Performance Devices (LEC) CY AUG 07-09, 2012 CL Brown Univ, Providence, RI SP IEEE, IEEE Electron Devices Soc, AF Off Sci Res, Off Naval Res HO Brown Univ DE thyristors; power semiconductor switches; pulse power system switches; pulse-shaping circuits ID THYRISTORS; KV AB The U. S. Army Research Laboratory has been driving the advancement of high-voltage, high-current silicon carbide devices and packaging through collaborations with Cree, Inc. and Silicon Power Corp. This paper reports on 1.0 cm(2) Super-GTOs fabricated by Cree, packaged by Silicon Power, and evaluated under pulse conditions at the Army Research Laboratory. These semiconductor switches were utilized to rapidly discharge capacitive energy into a resistive load. The Super-GTOs were packaged in parallel pairs using low-inductance thinPak lids for 2.0 cm(2) total silicon carbide area with high-voltage blocking capability up to 9.0 kV. The two-chip arrays were switched at three different pulse widths, ranging from 45 mu s to 75 mu s (full-width at half-maximum), up to peak current capability. The maximum current switched was 11.7 kA, corresponding to 8.0 kA/cm(2) over the mesa, with a 10-90% dI/dt of 1.5 kA/mu s. Two arrays were also paralleled and switched to 18 kA with current sharing within 1%. Individually the arrays were also reliably switched up to 100 pulses. The results are encouraging for the device design and packaging techniques, and for the capability of paralleling many devices to reach higher pulse currents. C1 [O'Brien, Heather; Ogunniyi, Aderinto; Scozzie, Charles] USA, Res Lab, Adelphi, MD 20783 USA. RP O'Brien, H (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM heather.k.obrien@us.army.mil NR 8 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-4905 BN 978-1-4673-2298-0 J9 P IEEE LES EASTM PY 2012 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BDW50 UT WOS:000315336700015 ER PT S AU Rodak, LE Sampath, AV Gallinat, CS Enck, RW Smith, J Shen, H Wraback, M Chen, Y Zhou, Q Campbell, JC AF Rodak, L. E. Sampath, A. V. Gallinat, C. S. Enck, R. W. Smith, J. Shen, H. Wraback, M. Chen, Y. Zhou, Q. Campbell, J. C. GP IEEE TI Aluminum Gallium Nitride/Silicon Carbide Separate Absorption and Multiplication Avalanche Photodiodes SO 2012 LESTER EASTMAN CONFERENCE ON HIGH PERFORMANCE DEVICES (LEC) SE Proceedings IEEE Lester Eastman Conference on High Performance Devices LA English DT Proceedings Paper CT IEEE Lester Eastman Conference on High Performance Devices (LEC) CY AUG 07-09, 2012 CL Brown Univ, Providence, RI SP IEEE, IEEE Electron Devices Soc, AF Off Sci Res, Off Naval Res HO Brown Univ DE avalanche photodiode; aluminum gallium nitride; silicon carbide; ultra-violet AB AlGaN/SiC separate absorption and multiplication avalanche photodiodes (SAM-APD) offer a unique approach for fabricating high gain photodetectors with tunable absorption in the deep ultraviolet regime. However, unlike conventional heterojunction SAM APDs, the formation of charge at the hetero-interface arising from spontaneous and piezoelectric polarization can dramatically affect device performance. This paper discusses the role of interface charge on device operation and the use of nitride interface control layers as a means to optimize it. A thin AlN layer inserted at the AlGaN/SiC hetero-interface is shown to be effective in reducing the net interface charge. C1 [Rodak, L. E.; Sampath, A. V.; Gallinat, C. S.; Enck, R. W.; Smith, J.; Shen, H.; Wraback, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Rodak, LE (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 7 TC 0 Z9 0 U1 2 U2 8 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-4905 BN 978-1-4673-2298-0 J9 P IEEE LES EASTM PY 2012 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BDW50 UT WOS:000315336700027 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI When a cold wind blew in (the dilemma of business leadership, one for all or all for one?) SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Article; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP 1 EP + D2 10.1057/9781137023438 PG 38 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100002 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI FOREWORD BY LIEUTENANT GENERAL DAVID G. PERKINS SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Editorial Material; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP XIII EP XIV D2 10.1057/9781137023438 PG 2 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100001 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI The changing face of leadership in the global context SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Article; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP 37 EP 72 D2 10.1057/9781137023438 PG 36 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100003 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI Empowerment and risk as a source of competitive advantage SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Article; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP 73 EP 95 D2 10.1057/9781137023438 PG 23 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100004 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI Culture: an essential framework for output performance SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Article; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP 97 EP 120 D2 10.1057/9781137023438 PG 24 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100005 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI The tools of the trade SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Article; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP 121 EP 142 D2 10.1057/9781137023438 PG 22 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100006 ER PT J AU Perkins, DG AF Perkins, David G. BA Yardley, I Kakabadse, A Neal, D BF Yardley, I Kakabadse, A Neal, D TI You've got to find what you love: engagement beyond transaction SO FROM BATTLEFIELD TO BOARDROOM: MAKING THE DIFFERENCE THROUGH VALUES-BASED LEADERSHIP LA English DT Article; Book Chapter C1 [Perkins, David G.] USA, Washington, DC USA. RP Perkins, DG (reprint author), USA, Mission Command, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-1-137-02343-8 PY 2012 BP 143 EP 164 D2 10.1057/9781137023438 PG 22 WC Business; Management SC Business & Economics GA BDU43 UT WOS:000314884100007 ER PT S AU Chen, JF Grandusky, JR Mendrick, MC Gibb, SR Moe, C Wraback, M Kim, YS Lin, SY Schowalter, LJ AF Chen, Jianfeng (Jeff) Grandusky, James R. Mendrick, Mark C. Gibb, Shawn R. Moe, Craig Wraback, Michael Kim, Yong-Sung Lin, Shawn-Yu Schowalter, Leo J. GP IEEE TI 260 nm Pseudomorphic Ultraviolet Light Emitting Diodes with Enhanced Photon Extraction Efficiency SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB We designed and fabricated 260 nm ultraviolet LEDs which demonstrated 20mW with greater than 1.5% WPE. Through surface roughening, substrate thinning and encapsulation, a 6x improvement in photon extraction efficiency has been achieved. C1 [Chen, Jianfeng (Jeff); Grandusky, James R.; Mendrick, Mark C.; Gibb, Shawn R.; Schowalter, Leo J.] Crystal IS, 70 Cohoes Ave, Green Isl, NY 12183 USA. [Moe, Craig; Wraback, Michael] Army Res Lab, Adelphi, MD 20783 USA. [Kim, Yong-Sung; Lin, Shawn-Yu] Rensselaer Polytech Inst, Troy, NY 12180 USA. RP Chen, JF (reprint author), Crystal IS, 70 Cohoes Ave, Green Isl, NY 12183 USA. EM chen@crystal-is.com FU DARPA under the Compact Mid-Ultraviolet Technology (CMUVT) program; Army Research Laboratory [W911NF-09-2-0068] FX This work was supported in part by DARPA under the Compact Mid-Ultraviolet Technology (CMUVT) program and by the Army Research Laboratory under Cooperative Agreement Number W911NF-09-2-0068. NR 1 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362402241 ER PT S AU Connelly, BC Gallinat, CS Woodward, NT Enck, RW Metcalfe, GD Tompkins, R Zhou, S Jones, KA Shen, PH Wraback, M AF Connelly, Blair C. Gallinat, Chad S. Woodward, Nathaniel T. Enck, Ryan W. Metcalfe, Grace D. Tompkins, Randy Zhou, Shuai Jones, Kenneth A. Shen, Paul H. Wraback, Michael GP IEEE TI Polarization Enhanced Carrier Transport in a p-down n-GaN/i-InGaN/p-GaN Solar Cell Structure SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB Evidence of a strong electric field aiding carrier collection is observed in an n-GaN/i-InGaN/p-GaN inverted polarity solar cell structure, detected by pump-probe electroabsorption and THz spectroscopy. C1 [Connelly, Blair C.; Gallinat, Chad S.; Woodward, Nathaniel T.; Enck, Ryan W.; Metcalfe, Grace D.; Tompkins, Randy; Zhou, Shuai; Jones, Kenneth A.; Shen, Paul H.; Wraback, Michael] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. RP Connelly, BC (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM blair.connelly.ctr@mail.mil NR 6 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362400138 ER PT S AU Garrett, GA Rotella, P Shen, HG Wraback, M Wunderer, T Chua, CL Yang, ZH Northrup, JE Johnson, NM AF Garrett, Gregory A. Rotella, Paul Shen, Hongen Wraback, Michael Wunderer, Thomas Chua, Christopher L. Yang, Zhihong Northrup, John E. Johnson, Noble M. GP IEEE TI Sub-Threshold Time-Resolved Spectroscopy of Mid-UV AlGaN Laser Diode Structures Pseudomorphically Grown on Bulk AlN SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB AlGaN based heterostructures exhibit photo-pumped stimulated emission out to 237 nm with a switched from TE to TM polarized observed. PL lifetimes reflect the stronger exciton binding energy of the higher Al content material. C1 [Garrett, Gregory A.; Rotella, Paul; Shen, Hongen; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Wunderer, Thomas; Chua, Christopher L.; Yang, Zhihong; Northrup, John E.; Johnson, Noble M.] Palo Alto Res Ctr Inc, Palo Alto, CA 94304 USA. RP Garrett, GA (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gregory.a.garrett@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362401413 ER PT S AU Metcalfe, GD Gallinat, CS Shen, HG Wraback, M Wienecke, S Young, EC Speck, JS AF Metcalfe, Grace D. Gallinat, Chad S. Shen, Hongen Wraback, Michael Wienecke, Steven Young, Erin C. Speck, James S. GP IEEE TI Effects of Strain Relaxation on the Photoluminescence of Semipolar InGaN SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB We present the effects of partial strain relaxation on the optical properties in lattice mismatched semipolar (1122) InGaN using polarization-dependent photoluminescence measurements to probe the strain dependent band mixing of the valence bands. C1 [Metcalfe, Grace D.; Gallinat, Chad S.; Shen, Hongen; Wraback, Michael] USA, Sensors & Elect Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Wienecke, Steven] Univ Calif Santa Barbara, Dept Elect & Comp Engn, \, Santa Barbara, CA 93106 USA. [Young, Erin C.; Speck, James S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. RP Metcalfe, GD (reprint author), USA, Sensors & Elect Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil NR 5 TC 0 Z9 0 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362402239 ER PT S AU Pritchett, TM Sun, WF Zhang, BG Li, YJ Haley, JE AF Pritchett, Timothy M. Sun, Wenfang Zhang, Bingguang Li, Yunjing Haley, Joy E. GP IEEE TI Z-scan Measurements of the Excited State Absorption Cross Sections of a Benzothiazolylfluorenylethynyl-Substituted Terpyridyl Platinum(II) Complex SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA ID PHOTOPHYSICS AB Using Z scans employing 4.1-ns and 21-ps pulses, values of 4.0x10(-17) cm(2) and 4.2x10(-17) cm(2) were obtained for the singlet and triplet excited-state absorption cross sections of 4'-[2-(7-benzothiazolyl-9,9-diethylfluoren-2-yl) ethynyl]-2,2':6',2 ''-terpyridyl platinum(II) chloride at 532 nm. (C) 2012 Optical Society of America C1 [Pritchett, Timothy M.] USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Sun, Wenfang; Zhang, Bingguang; Li, Yunjing] North Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA. [Haley, Joy E.] Materials & Mfg Directorate, Air Force Res lab, Wright Patterson AFB, OH 45433 USA. RP Pritchett, TM (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM timothy.m.pritchett.civ@mail.mil NR 6 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362400045 ER PT S AU Quraishi, Q Malinovsky, VS Alexander, J Prieto, V Rowlett, C Lee, P AF Quraishi, Qudsia Malinovsky, Vladimir S. Alexander, Jason Prieto, Violeta Rowlett, Chris Lee, Patricia GP IEEE TI Neutral atomic spin control with optical frequency combs SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB A technique to drive stimulated optical Raman transitions between spin and/or momentum states of ultracold Rb-87 atoms in a waveguide micro chip trap is discussed. (C) 2011 Optical Society of America C1 [Quraishi, Qudsia; Malinovsky, Vladimir S.; Alexander, Jason; Prieto, Violeta; Rowlett, Chris; Lee, Patricia] USA, Res Lab, Adelphi, MD 20783 USA. RP Quraishi, Q (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM qudsia.quraishi@gmail.com RI Lee, Patricia/B-6146-2012 NR 2 TC 0 Z9 0 U1 0 U2 7 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362401472 ER PT S AU Satyan, N Vasilyev, A Rakuljic, G White, JO Yariv, A AF Satyan, Naresh Vasilyev, Arseny Rakuljic, George White, Jeffrey O. Yariv, Amnon GP IEEE TI Phase-Locking and Coherent Power Combining of Linearly Chirped Optical Waves SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA ID YTTERBIUM FIBER AMPLIFIERS AB Rapidly chirped optical waveforms reduce stimulated Brillouin scattering in fiber amplifiers, enabling higher output powers. This work demonstrates homodyne and heterodyne phase-locking, and coherent combining, of linearly chirped optical waves using acoustooptic frequency shifters. (C) 2011 Optical Society of America C1 [Satyan, Naresh; Vasilyev, Arseny; Yariv, Amnon] CALTECH, Dept Appl Phys & Mat Sci, 1200 E Calif Blvd 136-93, Pasadena, CA 91125 USA. [Rakuljic, George] Telaris Inc, Santa Monica, CA 90403 USA. [White, Jeffrey O.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Satyan, N (reprint author), CALTECH, Dept Appl Phys & Mat Sci, 1200 E Calif Blvd 136-93, Pasadena, CA 91125 USA. EM naresh@caltech.edu FU DARPA (MTO); High Energy Laser Joint Technology Office FX The authors acknowledge the support of DARPA (MTO), and the High Energy Laser Joint Technology Office. NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362400164 ER PT S AU Shatalov, M Lunev, A Hu, X Sun, W Jain, R Yang, J Dobrinsky, A Deng, J Bilenko, Y Moe, CG Wraback, M Shur, M Gaska, R AF Shatalov, M. Lunev, A. Hu, X. Sun, W. Jain, R. Yang, J. Dobrinsky, A. Deng, J. Bilenko, Yu. Moe, C. G. Wraback, M. Shur, M. Gaska, R. GP IEEE TI Efficient UV Emitters for Sensing and Disinfection SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB Deep UV LED structures with UV transparent design, highly reflective p-electrodes and die encapsulation exhibited peak external quantum efficiencies up to 5%. Modeling indicates further increases in efficiency through reduced defect-related nonradiative recombination. C1 [Shatalov, M.; Lunev, A.; Hu, X.; Sun, W.; Jain, R.; Yang, J.; Dobrinsky, A.; Deng, J.; Bilenko, Yu.; Gaska, R.] Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA. [Moe, C. G.; Wraback, M.] Army Res Lab, Adelphi, MD 20783 USA. [Shur, M.] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. RP Shatalov, M (reprint author), Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA. EM shatalov@s-et.com RI Shur, Michael/A-4374-2016 OI Shur, Michael/0000-0003-0976-6232 NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362401412 ER PT S AU Ter-Gabrielyan, N Fromzel, V Ryba-Romanowski, W Lukasiewicz, T Dubinskii, M AF Ter-Gabrielyan, N. Fromzel, V. Ryba-Romanowski, W. Lukasiewicz, T. Dubinskii, M. GP IEEE TI Efficient, Resonantly Diode-Pumped, Eye-safe Laser Based on Er3+:GdVO4 SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA ID ER3+/YVO4 LASER; ABSORPTION AB We report what is believed to be the first resonantly-pumped demonstration of Er3+:GdVO4 laser. Slope efficiency of similar to 53% has been achieved at 1598.5 nm with laser diode bar stack pumping at 1529 nm. C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Ryba-Romanowski, W.] Inst Low Temperatures & Struct Res, PL-50422 Wroclaw, Poland. [Lukasiewicz, T.] Inst Elect Mat Technol, PL-01919 Warsaw, Poland. RP Ter-Gabrielyan, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM nikolay.e.tergabrielyan.civ@mail.mil NR 8 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362400312 ER PT S AU Valenzuela, AR Munson, CA Porwitzky, AJ AF Valenzuela, Anthony R. Munson, Chase A. Porwitzky, Andrew J. GP IEEE TI Filament Ablation of Opaque Solid Material SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA ID TRANSPARENT MEDIA AB Filamentation of femtosecond laser pulses defy diffraction and exist for many meters. The filament contains the concentrated laser pulse and a plasma column in its wake. We study filament ablation of metal and polymer surfaces. C1 [Valenzuela, Anthony R.; Munson, Chase A.; Porwitzky, Andrew J.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Valenzuela, AR (reprint author), USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM anthony.r.valenzuela6.civ@mail.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362400389 ER PT S AU Wang, K Strycker, BD Voronine, DV Jha, PK Scully, MO Meyers, RE Hemmer, P Sokolov, AV AF Wang, Kai Strycker, Benjamin D. Voronine, Dmitri V. Jha, Pankaj K. Scully, Marlan O. Meyers, Ronald E. Hemmer, Philip Sokolov, Alexei V. GP IEEE TI Femtosecond Laser Filaments Allow Remote Imaging beyond Diffraction Limit SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB We demonstrate a scheme which achieves sub-diffraction-limited imaging of remote objects by using femtosecond laser filaments. C1 [Wang, Kai; Strycker, Benjamin D.; Voronine, Dmitri V.; Jha, Pankaj K.; Scully, Marlan O.; Hemmer, Philip; Sokolov, Alexei V.] Texas A&M Univ, Inst Quantum Sci & Engn, College Stn, TX 77843 USA. [Meyers, Ronald E.] US Army Res Lab, Adelphi, MD 20783 USA. [Scully, Marlan O.] Princeton Univ, Princeton, NJ 08544 USA. RP Wang, K (reprint author), Texas A&M Univ, Inst Quantum Sci & Engn, College Stn, TX 77843 USA. EM sokol@physics.tamu.edu NR 3 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362400382 ER PT S AU Woodward, NT Metcalfe, GD Enck, R Gallinat, CS Shen, H Wraback, M AF Woodward, Nathaniel T. Metcalfe, G. D. Enck, R. Gallinat, C. S. Shen, H. Wraback, M. GP IEEE TI THz Emission from a-plane InGaN SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB Terahertz emission from high stacking fault density a-plane InGaN utilizing in-plane drift fields is shown to produce considerable improvement over c-plane InGaN under identical excitation conditions. C1 [Woodward, Nathaniel T.; Metcalfe, G. D.; Enck, R.; Gallinat, C. S.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Elect Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. RP Woodward, NT (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM Nathaniel.woodward2.ctr@mail.mil NR 3 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362402174 ER PT S AU Zehnpfennig, J Letarte, M Sadowski, RW Raftery, JJ AF Zehnpfennig, John Letarte, Matthew Sadowski, Robert W. Raftery, James J., Jr. GP IEEE TI Surface Optomechanics: Calculation of Love Surface Acoustic Waves on Microresonators SO 2012 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) SE Conference on Lasers and Electro-Optics LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO) CY MAY 06-11, 2012 CL San Jose, CA AB We calculate optomechanically excited Love waves on the surface of a silica whispering-gallery microresonator surrounded by air and pollutants. We show a method for sensing and distinguishing type or concentration of pollutant via frequency shift. C1 [Zehnpfennig, John; Letarte, Matthew; Sadowski, Robert W.; Raftery, James J., Jr.] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA. RP Zehnpfennig, J (reprint author), US Mil Acad, Photon Res Ctr, 646 Swift Rd, West Point, NY 10996 USA. EM john.zehnpfennig@usma.edu NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2160-9020 BN 978-1-55752-933-6 J9 CONF LASER ELECTR PY 2012 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BCK05 UT WOS:000310362402122 ER PT B AU Wheeler, DM Angell, J Hasan, MS AF Wheeler, David M. Angell, Joey Hasan, M. Sayeed GP IEEE TI A Constraint Satisfaction Language for Intelligent Self-Correction of Software-Defined Radio Configurations SO 2012 IEEE INTERNATIONAL CONFERENCE ON WIRELESS INFORMATION TECHNOLOGY AND SYSTEMS (ICWITS) LA English DT Proceedings Paper CT IEEE International Conference on Wireless Information Technology and Systems (ICWITS) CY NOV 11-16, 2012 CL Maui, HI SP IEEE, IEEE Antennas & Propagat Soc, IEEE Commun Soc, IEEE Microwave Theory & Techniques Soc (IEEE MTT-S), Agilent Technologies, Natl Sci Fdn (NSF), Anritsu AB This paper presents an embedded Artificial Intelligence (AI) engine based on Constraint Satisfaction Graphs (CSG) that enables rapid analysis and modification of networked Software Defined Radio (SDR) configurations. We developed a Constraint Satisfaction Language (CSL), an extensible AI framework for solving CSGs, and a set of unique strategy modules, and combined them to provide a scalable configuration troubleshooting tool for large complex SDR networks. These elements are combined into a tool called CINCH (Cognitive Interactive Network Configuration Helper). CINCH runs on an Android tablet, and can analyze hundreds of SDR configuration files, each with large numbers of parameters, in less than a minute. The extensible framework allows rapid support of additional SDR waveforms. In addition, the integration of this solution into a Cognitive Radio (CR) framework, to enable real-time modification of CR settings, is feasible with minimal effort. C1 [Wheeler, David M.; Angell, Joey] SecureComm Inc, Gilbert, AZ 85296 USA. [Hasan, M. Sayeed] US Army, Aberdeen Proving Ground, MD 21010 USA. RP Wheeler, DM (reprint author), SecureComm Inc, Gilbert, AZ 85296 USA. EM david.wheeler@SecureCommConsulting.com; joey.angell@SecureCommConsulting.com; Sayeed.hasan@us.army.mil FU Space and Naval Warfare Systems Command (SPAWAR) [N66001-11-C-5211] FX Part of the work is being conducted for the JPEO JTRS and the Space and Naval Warfare Systems Command (SPAWAR) under contract No. N66001-11-C-5211 NR 5 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-0947-9; 978-1-4673-0946-2 PY 2012 PG 4 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BDT38 UT WOS:000314775300099 ER PT S AU Romano, J Rosario, D Nasrabadi, N AF Romano, Joao Rosario, Dalton Nasrabadi, Nasser GP IEEE TI COVARIANCE TRACE FOR POLARIMETRIC ANOMALY DETECTION SO 2012 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS) SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 22-27, 2012 CL Munich, GERMANY SP IEEE, IEEE Geosci & Remote Sensing Soc, DLR, ESA DE Longwave infrared; polarization; stokes AB We propose a new method for autonomous manmade object detection, which is solely based on the use of second order statistics from two polarization components (0 and 90 deg) of polarimetric imagery. Using the approach, manmade objects can be detected as anomalies in scenes spatially dominated by natural objects. The approach exploits a key discovery: manmade objects are separable from natural objects in the (0 and 90 deg) variance-covariance space, holding invariant to diurnal cycle variation and geometry of illumination. Testing real imagery acquired outdoor (0.55 km sensor-to-target range) showed that the approach significantly outperforms the classical use of Stokes vector and DOLP (degree of linear polarization) during a full diurnal cycle. C1 [Romano, Joao] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Romano, J (reprint author), USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4673-1159-5 J9 INT GEOSCI REMOTE SE PY 2012 BP 4233 EP 4236 DI 10.1109/IGARSS.2012.6351734 PG 4 WC Engineering, Electrical & Electronic; Geosciences, Multidisciplinary; Remote Sensing SC Engineering; Geology; Remote Sensing GA BDG99 UT WOS:000313189404079 ER PT S AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung GP IEEE TI CONTEXTUAL SVM FOR HYPERSPECTRAL CLASSIFICATION USING HILBERT SPACE EMBEDDING SO 2012 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS) SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 22-27, 2012 CL Munich, GERMANY SP IEEE, IEEE Geosci & Remote Sensing Soc, DLR, ESA DE Contextual Support Vector Machine; Hyperspectral Classification; Hilbert Space Embedding AB In this paper, a contextual Support Vector Machine (SVM) technique based on the principle of Hilbert Space Embedding (HSE) of a local hyperspectral data distribution into an Reproducing Kernel Hilbert Space (RKHS) is proposed to optimally exploit the spectral and local spatial information of the hyperspectral image. The idea of embedding is to map hyperspectral pixels in a local neighborhood into a single point in the RKHS that can uniquely represent those pixels collectively. Previously, the authors have employed an HSE called empirical mean map to build the contextual SVM. In this work, a weighted empirical mean map is utilized to exploit the similarities and variation in the local spatial information. For every pixel, a small set of the neighboring pixels in a hyperspectral image are mapped into an RKHS induced by a certain kernel (Eg. Gaussian RBF kernel) and then, the embedded point of these group of pixels is obtained by calculating the weighted empirical mean of these mapped points. The weights are determined based on the distance between the pixel in consideration and its neighbors. An SVM separating hyperplane is built to maximize the margin between classes formed by weighted empirical means. The proposed technique showed significant improvement over the existing contextual and composite kernels on two hyperspectral image data sets. C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, ATTN RDRL SES E, Adelphi, MD 20783 USA. RP Gurram, P (reprint author), USA, Res Lab, ATTN RDRL SES E, 2800 Powder Mill RD, Adelphi, MD 20783 USA. NR 6 TC 2 Z9 2 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4673-1159-5 J9 INT GEOSCI REMOTE SE PY 2012 BP 5470 EP 5473 DI 10.1109/IGARSS.2012.6352368 PG 4 WC Engineering, Electrical & Electronic; Geosciences, Multidisciplinary; Remote Sensing SC Engineering; Geology; Remote Sensing GA BDG99 UT WOS:000313189405123 ER PT S AU Mehmood, A Patel, VM Damarla, T AF Mehmood, Asif Patel, Vishal M. Damarla, Thyagaraju GP IEEE TI DISCRIMINATION OF BIPEDS FROM QUADRUPEDS USING SEISMIC FOOTSTEP SIGNATURES SO 2012 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS) SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 22-27, 2012 CL Munich, GERMANY SP IEEE, IEEE Geosci & Remote Sensing Soc, DLR, ESA DE Seismic signatures; intrusion detection; geo-physical signal processing; footstep detection; Wigner-Ville distribution AB Seismic sensors are widely used to detect moving targets in the ground sensor network, and can be easily employed to discriminate human and quadruped based on their footstep signatures. Because of the complex environmental conditions and the non-stationary nature of the seismic signals, footstep detection and classification is a very challenging problem. The solution to this problem has various applications such as border security, surveillance, perimeter protection and intruder detection. Previous works in the domain of seismic detection of human vs. quadruped have relied on the cadence frequency-based models. However, cadence-based detection alone results in high false alarms. In this paper, we describe a seismic footstep database and present classification results based on support vector machine (SVM). We demonstrate that in addition to applying a good classification algorithm, finding robust features are very important for seismic discrimination. C1 [Mehmood, Asif; Damarla, Thyagaraju] USA, Res Lab, Adelphi, MD 20783 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.mehmood1.ctr@mail.mil; pvishalm@umiacs.umd.edu; thyagaraju.damarla.civ@mail.mil NR 14 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4673-1159-5 J9 INT GEOSCI REMOTE SE PY 2012 BP 6920 EP 6923 DI 10.1109/IGARSS.2012.6352571 PG 4 WC Engineering, Electrical & Electronic; Geosciences, Multidisciplinary; Remote Sensing SC Engineering; Geology; Remote Sensing GA BDG99 UT WOS:000313189406223 ER PT S AU Nguyen, LH Tran, TD AF Nguyen, Lam H. Tran, Trac D. GP IEEE TI ROBUST AND ADAPTIVE EXTRACTION OF RFI SIGNALS FROM ULTRA-WIDEBAND RADAR DATA SO 2012 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM (IGARSS) SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium (IGARSS) CY JUL 22-27, 2012 CL Munich, GERMANY SP IEEE, IEEE Geosci & Remote Sensing Soc, DLR, ESA DE synthetic aperture radar (SAR); ultra-wideband (UWB) radar; radio frequency interference; RFI; sparse recovery; compressed sensing (CS) ID MATCHING PURSUIT; ALGORITHM AB In this paper, we propose a novel, robust, and adaptive technique for the extraction of radio frequency interference (RFI) signals from ultra-wideband (UWB) radar data via sparse recovery. Unlike notch-filtering techniques that have been widely employed in the past, our proposed technique directly estimates and suppresses RFI signals from the UWB radar signal directly in time domain. Therefore, it does not suffer from several detrimental side effects such as high-sidelobe distortion and target-amplitude reduction as often observed in notch-filtering approaches. In addition, the technique is completely adaptive with highly time-varying environments and does not assume any knowledge (from frequency band to modulation scheme) of the RFI sources. The proposed technique is based on a sparse-recovery approach that simultaneously solves for (i) the UWB radar signal embedded in RFI noise with large amplitudes and (ii) RFI signals. Using both simulated and real-world data measured by the U. S. Army Research Laboratory (ARL) UWB synthetic aperture radar (SAR), we show that our proposed RFI extraction technique successfully recovers the UWB radar signal embedded in large-amplitude RFI signals. An average of 12 dB of RFI suppression is consistently realized in the real radar data experiments. C1 [Nguyen, Lam H.] USA, Res Lab, Adelphi, MD 20783 USA. RP Nguyen, LH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 14 TC 5 Z9 5 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4673-1159-5 J9 INT GEOSCI REMOTE SE PY 2012 BP 7137 EP 7140 DI 10.1109/IGARSS.2012.6352017 PG 4 WC Engineering, Electrical & Electronic; Geosciences, Multidisciplinary; Remote Sensing SC Engineering; Geology; Remote Sensing GA BDG99 UT WOS:000313189407021 ER PT S AU Zhivov, A Liesen, RJ Richter, S Jank, R Underwood, DM Neth, D Woody, A Bjork, C Duncan, S AF Zhivov, Alexander Liesen, Richard J. Richter, Stephan Jank, Reinhard Underwood, David M. Neth, Dieter Woody, Alfred Bjork, Curt Duncan, Scot GP ASHRAE TI Net Zero Building Cluster Energy Systems Analysis for US Army Installations SO ASHRAE TRANSACTIONS 2012, VOL 118, PT 1 SE ASHRAE Transactions LA English DT Proceedings Paper CT ASHRAE Winter Conference CY 2012 CL Chicago, IL SP ASHRAE AB The Army is required by law (EPACT 2005, EISA 2007) to eliminate fossil fuel use in new and renovated facilities by 2030 and to reduce overall facility energy usage by 30% by 2015. Army policy is to achieve eight net zero energy pilot installations by 2020, 25 net zero energy installations by 2031, and for all installations to achieve net zero energy status by 2058. Achieving Net Zero Energy (NZE) will only be possible if an optimum mix of demand reduction and renewable sources are put in place at a community (installation) or building cluster scale. The Army operates what are essentially small campuses, or clusters of buildings on its installations. The US Department of Energy (DOE) is focused on the national grid scale or on individual buildings, while the commercial focus is on retrofits to individual buildings. There are only few case studies worldwide that address dynamics of energy systems at the community scale, and to date, there is a lack of tools to perform that task. The building stock at most US Army installations is complex and includes a mix of high and low energy use buildings. Energy use in these buildings varies due to the different military mission and requirements for each building, installation growth and expansion, and soldier deployment. Achieving net zero energy economically at such installations will require a seamless blend of energy conservation in individual buildings and building systems automation, utility management and control, and power delivery systems that have the capability to offer integration of on-site power generation (including renewable energy sources). This paper describes the Net Zero fossil fuel based energy optimization process and illustrates it with an example based on the results of study conducted for a cluster of buildings at Fort Irwin, CA. The integrated optimization process is being developed under the Army research and development project "Modeling Net Zero Installations - Energy (NZI-E)" and the International Energy Agency (IEA) Energy Conservation in Buildings and Community Systems (ECBCS) Annex 51. The process is stepped, beginning with the optimization of each building to achieve the most cost effective energy efficient optimization of building envelope and energy using systems. Then energy saving measures affecting the total building cluster are optimized taking advantages of the diversification between energy intensities, scheduling, and waste energy streams utilization. The energy demands of the resulting energy-use optimized cluster will require the minimum sized renewable energy system needed to make the building cluster Net Zero fossil fuel energy. C1 [Zhivov, Alexander; Liesen, Richard J.; Underwood, David M.] USA, Engineer Res & Dev Ctr, Champaign, IL USA. RP Zhivov, A (reprint author), USA, Engineer Res & Dev Ctr, Champaign, IL USA. NR 14 TC 1 Z9 1 U1 0 U2 5 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2505 J9 ASHRAE TRAN PY 2012 VL 118 BP 751 EP 766 PN 1 PG 16 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BDC57 UT WOS:000312640000090 ER PT S AU Liesen, R Ellis, P Zhivov, A Herron, D AF Liesen, Richard Ellis, Peter Zhivov, Alexander Herron, Dale GP ASHRAE TI Extremely Low Energy Design for Army Buildings: Barracks SO ASHRAE TRANSACTIONS 2012, VOL 118, PT 1 SE ASHRAE Transactions LA English DT Proceedings Paper CT ASHRAE Winter Conference CY 2012 CL Chicago, IL SP ASHRAE AB The 2007 Energy Independence and Security Act (EISA) require that all new federal facilities be built fossil fuel free by 2030. This raises the bar considerably from the 2005 Energy Policy Act, which required federal facilities be built to achieve at least 30% energy savings over ASHRAE Standard 90.1 - 2004. On the trajectory towards the 2030 goal, buildings have to meet 65% decrease of source energy from the Commercial Building Energy Consumption Survey (CBECS) survey for the building type specified. The EISA requirement is not a comparison between a baseline and an energy efficient simulation, but a direct comparison with the actual results from the final simulation with the EISA target. This is not a delta percentage comparison; it includes total source energy and all the building loads must be addressed and not left out of the calculation as an unregulated portion of the building load. The result of the study was guidance on how to reach a 60-80% energy use reduction from Commercial Building Energy Consumption Study (CBECS). The 2005 Energy Policy Act requires that federal facilities be built to achieve at least a 30% energy savings over the 2004 ASHRAE Standard 90.1-2004. The Construction Engineering Research Laboratory (CERL) of the U. S. Army Corps of Engineers in collaboration with USACE HQ and Centers of Standardization for respective building types, subject matter expert (SME) contractors, and the DOE National Renewable Energy Laboratory (NREL) participated in a study to recommend design guides to achieve the Federal requirements for new buildings to be constructed under the Military Transformation Program. The building types included Unaccompanied Enlisted Personnel Housing or UEPH, administrative buildings (e. g., a brigade head-quarters, and a company operation facility), a tactical equipment maintenance facility, and a dining facility. This paper presents the results of the energy analysis for the soldier barracks (UEPH). It provides the baseline building selected for the analysis and the modeling assumptions. As a result of a computer analysis using EnergyPlus, the target energy budgets are defined for all DOE 15 Climate Zones. Finally, a recommended set of energy efficient solutions for each climate zone is presented that shows the buildings limit as it approached net zero ready. It shows potential energy savings both on the building site and source energy when energy use reduction is considered on a building-by-building basis. It also shows further energy use reduction opportunities when energy improvements are made with each building considered as a part of the building cluster or community. C1 [Liesen, Richard; Ellis, Peter; Zhivov, Alexander; Herron, Dale] USA, Corps Engineers, Construct Energy Res Lab, Champaign, IL 61822 USA. RP Liesen, R (reprint author), USA, Corps Engineers, Construct Energy Res Lab, Champaign, IL 61822 USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2505 J9 ASHRAE TRAN PY 2012 VL 118 BP 767 EP 789 PN 1 PG 23 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BDC57 UT WOS:000312640000091 ER PT S AU Deru, M Langner, R Zhivov, A Liesen, R Herron, D Smith, V AF Deru, Michael Langner, Rois Zhivov, Alexander Liesen, Richard Herron, Dale Smith, Vernon GP ASHRAE TI Extremely Low-Energy Design for Army Buildings: Dining Facility SO ASHRAE TRANSACTIONS 2012, VOL 118, PT 1 SE ASHRAE Transactions LA English DT Proceedings Paper CT ASHRAE Winter Conference CY 2012 CL Chicago, IL SP ASHRAE AB The U. S. Army Corps of Engineers, in collaboration with the U. S. Department of Energy's (DOE) National Renewable Energy Laboratory (NREL), academia, and private sector subject matter experts, recently completed an energy study to evaluate potential site and source energy-use reduction in new Army buildings. The study was completed in response to the mandates for energy savings in federal buildings enacted by the U. S. Energy Independence and Security Act of 2007 (U. S. Congress 2007). The building types studied included an Unaccompanied Enlisted Personnel Housing (UEPH or barracks), a brigade headquarters (administrative building), a company operation facility, a maintenance facility, and a dining facility (DFAC). The study was conducted for representative locations in all 15 DOE identified climate zones in the United States with building designs adapted to these climatic conditions. This paper presents the results of the energy analysis for a typical Army dining facility. It discusses energy efficiency measures and combinations used to reduce both internal and external loads on the building and overall energy use. The largest load in a DFAC is the cooking, and the currently available best-in-class kitchen equipment is included in the final design. The potential site energy savings compared to the energy code range from 21% to 38%. The potential source energy savings compared to Commercial Building Energy Consumption Survey ranges from 37% to 42%. Additional savings may be obtained if an efficient cogeneration system is used and the building is considered as apart of the building cluster or community to fully utilize the energy from the cogeneration system. C1 [Deru, Michael; Langner, Rois] Natl Renewable Energy Lab, Commercial Bldg Res Grp, Golden, CO 80401 USA. [Zhivov, Alexander; Liesen, Richard; Herron, Dale] US Army, ERDC, CERL, Champaign, IL USA. RP Deru, M (reprint author), Natl Renewable Energy Lab, Commercial Bldg Res Grp, Golden, CO 80401 USA. FU U.S. Army Corps of Engineers Headquarters under leadership of Daniel Carpio and in collaboration with the ACE Construction Engineering Research Laboratory and the National Renewable Energy Laboratory. FX This study was conducted by the U.S. Army Corps of Engineers Headquarters under leadership of Daniel Carpio and in collaboration with the ACE Construction Engineering Research Laboratory and the National Renewable Energy Laboratory. NR 17 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2505 J9 ASHRAE TRAN PY 2012 VL 118 BP 790 EP 815 PN 1 PG 26 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BDC57 UT WOS:000312640000092 ER PT S AU Langner, R Deru, M Zhivov, A Liesen, R Herron, D AF Langner, Rois Deru, Michael Zhivov, Alexander Liesen, Richard Herron, Dale GP ASHRAE TI Extremely Low-Energy Design for Army Buildings: Tactical Equipment Maintenance Facility SO ASHRAE TRANSACTIONS 2012, VOL 118, PT 1 SE ASHRAE Transactions LA English DT Proceedings Paper CT ASHRAE Winter Conference CY 2012 CL Chicago, IL SP ASHRAE AB The U. S. Army Corps of Engineers Headquarters, the U. S. Army Corps of Engineers Construction Energy Research Laboratory (CERL), and the National Renewable Energy Laboratory (NREL) worked together to explore the potential to reach the 2015 energy performance goal of the Energy Independence and Security Act of 2007: to reduce fossil fuel-generated energy consumption by 65% for five common military construction building types (U. S. Congress 2007). This report covers the analysis, approach, and results examining energy performance for the Army tactical equipment maintenance facility. Starting with a previous project by CERL and NREL that explored 30% energy savings for the Energy Policy Act of 2005 (U. S. Congress 2005), the current project was able to achieve 40%-63% site energy savings (depending on climate zone) compared to a baseline building model, and 51%-76% source energy savings compared to Commercial Buildings Energy Consumption Survey 2003 (EIA 2008) data for a similar building type. Recommended energy efficiency measures include passive house insulation standards, demand control ventilation strategies in the maintenance repair bays, radiant floor heating, transpired solar collectors, reduced lighting power densities, daylighting, and lighting control strategies. C1 [Langner, Rois; Deru, Michael] Natl Renewable Energy Lab, Commercial Bldg Res Grp, Golden, CO 80401 USA. [Zhivov, Alexander; Liesen, Richard; Herron, Dale] US Army, Army Engn Res & Dev Ctr, Energy Branch, Construct Engn Res Lab, Champaign, IL USA. RP Langner, R (reprint author), Natl Renewable Energy Lab, Commercial Bldg Res Grp, Golden, CO 80401 USA. NR 19 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 USA SN 0001-2505 J9 ASHRAE TRAN PY 2012 VL 118 BP 816 EP 830 PN 1 PG 15 WC Thermodynamics; Construction & Building Technology SC Thermodynamics; Construction & Building Technology GA BDC57 UT WOS:000312640000093 ER PT B AU Carter, DA AF Carter, Donald A. BE Hoffenaar, J Kruger, D TI War Games in Europe The US Army Experiments with Atomic Doctrine SO BLUEPRINTS FOR BATTLE: PLANNING FOR WAR IN CENTRAL EUROPE, 1948-1968 SE Foreign Military Studies LA English DT Article; Book Chapter C1 USA, Ctr Mil Hist, Washington, DC USA. RP Carter, DA (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU UNIV PRESS KENTUCKY PI LEXINGTON PA 102 LAFFERTY HALL, UNIVERSITY OF KENTUCKY, LEXINGTON, KY 40506 USA BN 978-0-8131-3652-3 J9 FOREIGN MIL STUD PY 2012 BP 131 EP 153 PG 23 WC History SC History GA BDG07 UT WOS:000313069200012 ER PT S AU Jelinek, B Solanki, K Peters, JF Felicelli, SD AF Jelinek, Bohumir Solanki, Kiran Peters, John F. Felicelli, Sergio D. BE Stocks, GM Troparevsky, MC TI Investigating robustness of interatomic potentials with universal interface SO IUPAP C20 CONFERENCE ON COMPUTATIONAL PHYSICS (CCP 2011) SE Journal of Physics Conference Series LA English DT Proceedings Paper CT 23rd IUPAP C20 Conference on Computational Physics (CCP) CY OCT 30-NOV 03, 2011 CL Gatlinburg, TN SP Int Union Pure & Appl Phys (IUPAP), Int Union Pure & Appl Phys (IUPAP), Commiss Computat Phys (C20), Amer Phys Soc, Div Computat Phys (APS-DCOMP), Oak Ridge Natl Lab (ORNL), Ctr Defect Phys (CDP), Univ Tennessee (UT)/ORNL, Joint Inst Computat Sci (JICS), Cray, Inc AB We present a set of Python routines to perform basic tests of classical atomistic potentials and their example applications. These routines are implemented using universal Atomic Simulation Environment (ASE) and LAMMPS molecular dynamics code. ASE is utilized to create atomic configurations, to write input scripts for LAMMPS, and to read results from output files. Evaluated properties are formation energies and volumes of simple point defects (vacancies, substitutions, and interstitials), formation energies of basic surfaces, heats of formation of simple binary compounds, and elastic constants. The flexibility of LAMMPS allows easy switching between different semi-empirical potentials, while the universality of ASE allows to compare results with a variety of electronic structure codes. C1 [Jelinek, Bohumir; Felicelli, Sergio D.] Mississippi State Univ, Ctr Adv Vehicular Syst, 200 Res Blvd, Starkville, MS 39759 USA. [Solanki, Kiran] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA. [Felicelli, Sergio D.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Peters, John F.] US Army Corp Engineers, Vicksburg, MS 39180 USA. RP Jelinek, B (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, 200 Res Blvd, Starkville, MS 39759 USA. EM bj48@cavs.msstate.edu RI Jelinek, Bohumir/C-4376-2008; OI Jelinek, Bohumir/0000-0002-2622-4235; Solanki, Kiran/0000-0002-4385-620X NR 7 TC 1 Z9 1 U1 2 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1742-6588 J9 J PHYS CONF SER PY 2012 VL 402 AR 012006 DI 10.1088/1742-6596/402/1/012006 PG 5 WC Physics, Multidisciplinary; Physics, Mathematical SC Physics GA BDS66 UT WOS:000314709800006 ER PT B AU Darsch, GA AF Darsch, Gerald A. BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Forward: Feeding the Warfighter SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Editorial Material; Book Chapter C1 USA, DoD Combat Feeding, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Darsch, GA (reprint author), USA, DoD Combat Feeding, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM Gerald.Darsch@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP XI EP XIII PG 3 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400001 ER PT J AU Yang, TCS AF Yang, Tom C. S. BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Thermal Processing of Rations SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter ID INTRINSIC CHEMICAL MARKERS; WHEY-PROTEIN GELS; LOW-ACID FOODS; PARTICULATE FOODS; MICROWAVE PASTEURIZATION; CLOSTRIDIUM-SPOROGENES; HEAT-RESISTANCE; STERILIZATION; SAFETY; VALIDATION C1 USA, Food Proc Engn & Technol Team, Combat Feed Directorate, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. RP Yang, TCS (reprint author), USA, Food Proc Engn & Technol Team, Combat Feed Directorate, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. EM tom.yang@us.army.mil NR 48 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 41 EP 67 PG 27 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400003 ER PT J AU Carter, M Favreau, N Oleksyk, L Dunne, CP AF Carter, Melvin Favreau, Nicole Oleksyk, Lauren Dunne, C. Patrick BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Emerging Technologies: Non-Thermal Processing for Quality Improvement SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter ID SUPERCRITICAL CARBON-DIOXIDE; PULSED ELECTRIC-FIELDS; HIGH-PRESSURE; HYDROSTATIC-PRESSURE; MICROBIAL INACTIVATION; BACTERIOCINS; SYSTEM; HEAT; COMBINATION; FOODS C1 [Carter, Melvin; Favreau, Nicole; Oleksyk, Lauren] USA, Food Proc & Engn Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Dunne, C. Patrick] USA, Off Director, Combat Feeding Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Carter, M (reprint author), USA, Food Proc & Engn Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. EM melvin.carter@us.army.mil; nicole.favreau@us.army.mil; cpatrick.dunne@us.army.mil NR 52 TC 0 Z9 0 U1 1 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 69 EP 101 PG 33 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400004 ER PT B AU Barrett, A Briggs, J AF Barrett, Ann Briggs, Jack BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Caloric Densification of Rations SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter C1 [Barrett, Ann] USA, Performance Optimizat Res Team, Combat Feeding Directorate, Natick Soldier R D & E Ctr, Natick, MA 01760 USA. [Briggs, Jack] USA, Food Proc & Engn Team, Combat Feeding Directorate, Natick Soldier R D & E Ctr, Natick, MA 01760 USA. RP Barrett, A (reprint author), USA, Performance Optimizat Res Team, Combat Feeding Directorate, Natick Soldier R D & E Ctr, Natick, MA 01760 USA. NR 28 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 103 EP 125 PG 23 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400005 ER PT B AU Nattress, D AF Nattress, Daniel BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Special-Purpose Rations: Tube Foods SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter C1 USA, Packaging Integrat Team, Combat Feeding Directorate, Natick Soldier R D & E Ctr, Natick, MA 01760 USA. RP Nattress, D (reprint author), USA, Packaging Integrat Team, Combat Feeding Directorate, Natick Soldier R D & E Ctr, Natick, MA 01760 USA. EM daniel.nattress@us.army.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 127 EP 136 PG 10 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400006 ER PT J AU Senecal, A Marek, P AF Senecal, Andre Marek, Patrick BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Military Food Safety Technologies SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter ID ESCHERICHIA-COLI O157-H7; QUASI-CHEMICAL MODEL; IMMUNOMAGNETIC SEPARATION; ANTIMICROBIAL PEPTIDES; LISTERIA-MONOCYTOGENES; STAPHYLOCOCCUS-AUREUS; INOCULUM SIZE; UNITED-STATES; GROUND-BEEF; SALMONELLA C1 [Senecal, Andre] USA, Natick Res Dev & Engn Ctr, Combat Feeding Directorate, Food Safety & Def Team, Natick, MA 01760 USA. [Marek, Patrick] USA, Natick Res Dev & Engn Ctr, Combat Feeding Directorate, Food Safety & Def Team, Natick, MA 01760 USA. RP Senecal, A (reprint author), USA, Natick Res Dev & Engn Ctr, Combat Feeding Directorate, Food Safety & Def Team, Natick, MA 01760 USA. EM Andre.senecal@us.army.mil; Patrick.marek@us.army.mil NR 73 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 157 EP 194 PG 38 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400008 ER PT J AU Froio, D Ratto, JA Lucciarini, J AF Froio, Danielle Ratto, Jo Ann Lucciarini, Jeanne BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Military Food Packaging Technologies SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter ID MICROLAYER COEXTRUSION; FILMS C1 [Froio, Danielle; Ratto, Jo Ann; Lucciarini, Jeanne] USA, Adv Mat Engn Team, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Froio, D (reprint author), USA, Adv Mat Engn Team, Natick Soldier Res Dev & Engn Ctr, Kansas St, Natick, MA 01760 USA. EM danielle.froio@us.army.mil; joann.ratto@us.army.mil; jeanne.lucciarini@us.army.mil NR 34 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 195 EP 223 PG 29 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400009 ER PT J AU Cardello, AV Schutz, HG Wright, AO AF Cardello, Armand V. Schutz, Howard G. Wright, Alan O. BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Consumer and Sensory Testing of Rations SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter ID FOOD-PROCESSING TECHNOLOGIES; LONG-TERM ACCEPTABILITY; LABELED MAGNITUDE SCALE; PERCEIVED SATIETY; IRRADIATED FOODS; TASTE INTENSITY; CATEGORY SCALES; ORAL SENSATIONS; PUBLIC CONCERNS; HEDONIC SCALES C1 [Cardello, Armand V.; Wright, Alan O.] USA, Natick Soldier Ctr, Natick, MA 01760 USA. [Schutz, Howard G.] Univ Calif Davis, Davis, CA 95618 USA. RP Cardello, AV (reprint author), USA, Natick Soldier Ctr, Natick, MA 01760 USA. NR 193 TC 0 Z9 0 U1 0 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 349 EP 406 PG 58 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400015 ER PT B AU Johnson, WK Dichiara, AJ AF Johnson, Wendy K. Dichiara, Adam J. BA Barrett, AH Cardello, AV BF Barrett, AH Cardello, AV TI Field Testing of Rations SO MILITARY FOOD ENGINEERING AND RATION TECHNOLOGY LA English DT Article; Book Chapter ID US-ARMY; FOOD; ACCEPTABILITY; ACCEPTANCE; RATINGS; CHOICE C1 [Johnson, Wendy K.; Dichiara, Adam J.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Johnson, WK (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, 15 Kansas St, Natick, MA 01760 USA. EM adam.dichiara@us.army.mil NR 34 TC 0 Z9 0 U1 1 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-049-5 PY 2012 BP 407 EP 431 PG 25 WC Food Science & Technology SC Food Science & Technology GA BDL03 UT WOS:000313628400016 ER PT J AU Muench, ST Scarsella, M Bradway, M Hormann, L Cornell, L AF Muench, Stephen T. Scarsella, Maleena Bradway, Margi Hormann, Liz Cornell, Lyn TI Evaluating Project-Based Roadway Sustainability Rating System for Public Agency Use SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Several road-owning organizations are considering the use of project-based sustainability rating systems either now or in the near future. However, there is little information on how these systems might be evaluated or best used. Experience from the Oregon Department of Transportation (DOT) represents a reasonable approach to contextualizing and evaluating such rating systems. Early support by upper management and specific direction helped the Oregon DOT develop an organizational approach to sustainability within which a rating system could be evaluated for use. The Oregon DOT's interest in project-based rating systems led to its evaluation of the Greenroads rating system and use of it on three Oregon DOT in-progress projects. The Greenroads evaluation identified 11 sustainability best practices achieved by the Oregon DOT and identified 10 more that could be achieved for low additional effort, indicating potential for improvement. Ultimately, it appears that a sustainability rating system, when used in the proper context, can provide a flexible approach for an owner agency to measure, manage, improve, and communicate sustainability at the project level. C1 [Muench, Stephen T.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA. [Scarsella, Maleena] USA, Corps Engineers, Seattle, WA 98134 USA. [Bradway, Margi; Hormann, Liz] Act Transportat Sect, Salem, OR 97301 USA. [Cornell, Lyn] Oregon Dept Transportat, Salem, OR 97301 USA. RP Muench, ST (reprint author), Univ Washington, Dept Civil & Environm Engn, Box 352700, Seattle, WA 98195 USA. EM stmuench@uw.edu FU Oregon Department of Transportation and Transportation Northwest (TransNow), the U.S. Department of Transportation Region 10 University Transportation Center FX This research was conducted under the sponsorship of the Oregon Department of Transportation and Transportation Northwest (TransNow), the U.S. Department of Transportation Region 10 University Transportation Center. Stephanie Garbacik, a University of Washington graduate research assistant, rated the OR-34 Roche Street Wolcott Road project referenced in this paper. NR 24 TC 2 Z9 2 U1 1 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2012 IS 2285 BP 8 EP 18 DI 10.3141/2285-02 PG 11 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 047YX UT WOS:000311878500003 ER PT J AU Berney, ES Kyzar, JD AF Berney, Ernest S. Kyzar, James D. TI Evaluation of Nonnuclear Soil Moisture and Density Devices for Field Quality Control SO TRANSPORTATION RESEARCH RECORD LA English DT Article ID COMPACTION AB When new transportation infrastructure is constructed or current infrastructure systems undergo maintenance, sufficient soil strength is critical to a successful construction effort. Currently, soil design specifications are given for a minimum soil density and a specified range of soil moisture content. Quality control is achieved by monitoring the soil density and moisture content throughout the construction process. The nuclear density gauge (NDG) is most commonly employed to determine soil density and moisture content because of its ease of use, speed of readings, and reliability of results. However, potential safety hazards and rigorous user certification requirements have led many agencies to seek alternative devices. This paper focuses on a portion of a much larger study that compared a wide range of compaction control devices; the paper also assesses the performance of devices that measure soil density and moisture content. Several new, commercially available alternatives for the measurement of soil density were tested on various soil types and conditions to determine which device performed best and most consistently. For the same soil types and conditions, several devices and techniques for the determination of soil moisture content were also tested. The combination of the TransTech soil density gauge and the heated frying pan-open flame field moisture content techniques represented the best alternative to the NDG. C1 [Berney, Ernest S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Kyzar, James D.] WGK Inc, Engineers & Surveyors, Clinton, MS 39056 USA. RP Berney, ES (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ernest.s.berney.IV@usace.army.mil NR 20 TC 4 Z9 4 U1 2 U2 6 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2012 IS 2310 BP 18 EP 26 DI 10.3141/2310-03 PG 9 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 085OV UT WOS:000314625000003 ER PT J AU Jersey, SR Tingle, JS Norwood, GJ Kwon, J Wayne, M AF Jersey, Sarah R. Tingle, Jeb S. Norwood, Gregory J. Kwon, Jayhyun Wayne, Mark TI Full-Scale Evaluation of Geogrid-Reinforced Thin Flexible Pavements SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB A full-sale test section was constructed and subjected to traffic loading at the U.S. Army Engineer Research and Development Center to evaluate the performance of a geogrid that was used for base reinforcement in a thin flexible pavement. Three test items-a geogrid-reinforced test item and two unreinforced control test items-were constructed under controlled conditions. The test pavements were subjected to accelerated traffic loading to evaluate the relative performance of the pavement structures. Pavement stiffness and permanent surface deformations were measured periodically throughout the testing. The study results showed that the geogrid-reinforced pavement performed better than the unreinforced control pavements did. The results were used to develop traffic benefit ratios and effective base course structural coefficients to enable comparison of the pavement structures. C1 [Jersey, Sarah R.] USA, Risk Management Ctr, Corps Engineers, Pittsburgh, PA 15222 USA. [Tingle, Jeb S.; Norwood, Gregory J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Kwon, Jayhyun; Wayne, Mark] Tensar Int Corp, Alpharetta, GA 30009 USA. RP Tingle, JS (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jeb.s.tingle@usace.army.mil FU Tensar International FX Unless otherwise noted, the tests described were sponsored by Tensar International, and performed by the U.S. Army Engineer Research and Development Center, Waterways Experiment Station. Permission was granted by the Director of the Geotechnical and Structures Laboratory and by Tensar International to publish information on these tests and the resulting data. NR 12 TC 1 Z9 1 U1 0 U2 4 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2012 IS 2310 BP 61 EP 71 DI 10.3141/2310-07 PG 11 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 085OV UT WOS:000314625000007 ER PT J AU McInvale, HD Retherford, JQ McDonald, MP AF McInvale, Howard D. Retherford, Jennifer Q. McDonald, Mark P. TI Load and Resistance Factors and Design Parameter Offsets for Mechanistic-Empirical Pavement Design Guide SO TRANSPORTATION RESEARCH RECORD LA English DT Article ID RELIABILITY-ANALYSIS; SIMULATION AB An approach to developing load and resistance factors and design parameter offsets for inputs to the Mechanistic Empirical Pavement Design Guide (MEPDG) is provided for the purpose of ensuring, with a high level of probability, that the MEPDG-predicted distress at any level of reliability does not exceed a given threshold. In the proposed approach, the two most significant sources of uncertainty in pavement design input variability and model prediction error are handled separately. The proposed method involves four major steps: experimental design, surrogate model estimation, model verification, and calculation of load and resistance factors and design offsets with the inverse first-order reliability method. The proposed method allows pavement engineers to account for uncertainty in loading and resistance parameters in a similar manner to the load and resistance factor design provisions of the American Institute of Steel Construction's Steel Construction Manual and the American Concrete Institute's ACI 318: Building Code Requirements for Structural Concrete. The proposed methods are illustrated for a typical flexible pavement. C1 [McInvale, Howard D.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Retherford, Jennifer Q.] Vanderbilt Univ, Dept Civil & Environm Engn, Stn B, Nashville, TN 37235 USA. [McDonald, Mark P.] Lipscomb Univ, Dept Civil & Environm Engn, Nashville, TN 37204 USA. RP McInvale, HD (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM doug.mcinvale@usma.edu RI Retherford, Jennifer/F-3560-2016 OI Retherford, Jennifer/0000-0003-2890-4098 NR 22 TC 1 Z9 1 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2012 IS 2305 BP 162 EP 169 DI 10.3141/2305-17 PG 8 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 090TQ UT WOS:000315003300017 ER PT S AU Li, T Amirloo, J Murray, J Sablon, KA Little, J Uppal, P Munday, J Dagenais, M AF Li, Tian Amirloo, J. Murray, J. Sablon, K. A. Little, J. Uppal, P. Munday, J. Dagenais, Mario GP IEEE TI A comparison of bulk and quantum dot GaAs solar cells SO 2012 IEEE PHOTONICS CONFERENCE (IPC) SE IEEE Photonics Conference LA English DT Proceedings Paper CT 25th IEEE Photonics Conference (IPC) CY SEP 23-27, 2012 CL Burlingame, CA SP IEEE, Kotura, Rockley Grp, Intel, Cisco, Oracle Labs, Corning, Google, Luxtera, Fiber Chip, Rambus, Analog Devices, PMC, Sinoora, Soitec, Photon Design, Nat Photon, Commun Technol Roadmap, Simgui C1 [Li, Tian; Amirloo, J.; Murray, J.; Munday, J.; Dagenais, Mario] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Sablon, K. A.; Little, J.; Uppal, P.] Army Res Lab, Adelphi, MD USA. RP Li, T (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. NR 2 TC 0 Z9 0 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2374-0140 BN 978-1-4577-0733-9 J9 IEEE PHOTON CONF PY 2012 BP 194 EP + PG 2 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BDD75 UT WOS:000312865000099 ER PT S AU Arezoumandi, M Ezzell, M Volz, JS AF Arezoumandi, Mahdi Ezzell, Mark Volz, Jeffery S. BE Shao, Y Hao, S Luo, Y Xing, J Liu, Z TI Development and Testing of Chemically-Based Self-Consolidating Concrete SO ADVANCED BUILDING MATERIALS AND SUSTAINABLE ARCHITECTURE, PTS 1-4 SE Applied Mechanics and Materials LA English DT Proceedings Paper CT 2nd International Conference on Civil Engineering, Architecture and Building Materials (CEABM 2012) CY MAY 25-27, 2012 CL Yantai, PEOPLES R CHINA SP Yantai Univ, Sch Civil Engn, Guizhou Univ, Coll Civil & Architecture Engn, Hainan Soc Theoret & Appl Mech DE Chemical Admixtures; Creep; Self-Consolidating Concrete; Shear Strength; Shrinkage ID SHEAR AB Self-consolidating concrete (SCC) has the potential to significantly reduce costs associated with concrete construction. SCC is a highly flowable, nonsegregating concrete that has a variety of advantages over conventional concrete (CC). However, SCC is not without its problems, which can include increased creep and shrinkage, as well as decreased bond and shear strength. The goal of this research project was to evaluate the creep, shrinkage, and shear behavior of a chemically-based SCC mix. One of the benefits of a chemically-based approach is the potential to eliminate the negative side effects of many SCC mixes. The investigation included development of the mix design, construction and testing of creep and shrinkage specimens, and construction and testing of full-scale beam specimens to evaluate the shear behavior. The results indicate that a chemically-based SCC performs as well or better than conventional portland-cement concrete. C1 [Arezoumandi, Mahdi; Volz, Jeffery S.] Missouri Univ Sci & Technol, Dept Civil Architectural & Environm Engn, Rolla, MO 65409 USA. [Ezzell, Mark] US Army, Corps Engn, St Louis, MO USA. RP Arezoumandi, M (reprint author), Missouri Univ Sci & Technol, Dept Civil Architectural & Environm Engn, Rolla, MO 65409 USA. EM ma526@mst.edu; mark.d.ezzell@usace.army.mil; volzj@mst.edu NR 16 TC 0 Z9 0 U1 0 U2 4 PU TRANS TECH PUBLICATIONS LTD PI DURNTEN-ZURICH PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND SN 1660-9336 BN 978-3-03785-423-5 J9 APPL MECH MATER PY 2012 VL 174-177 BP 11 EP + DI 10.4028/www.scientific.net/AMM.174-177.11 PG 3 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA BCZ86 UT WOS:000312234600002 ER PT J AU Gibson, PW Desabrais, K Godfrey, T AF Gibson, Phillip W. Desabrais, Kenneth Godfrey, Thomas TI Dynamic Permeability of Porous Elastic Fabrics SO JOURNAL OF ENGINEERED FIBERS AND FABRICS LA English DT Article; Proceedings Paper CT International Symposium on New Frontiers in Fiber Materials Science CY OCT 11-13, 2011 CL Charleston, SC AB This paper describes permeability measurements for porous fabrics as influenced by strain, humidity, air flow rate, and fabric elasticity. The focus is on standard parachute fabrics, where the fabric's porosity and air permeability influence the rate of steady-state descent, and also affect the complicated fluid-structure interactions taking place during parachute opening and deployment. High strength nylon parachute fabrics showed relatively small permeability changes due to strain, humidity, and flow rate. Comparative measurements on elastomeric fabrics showed much larger changes in air flow due to fabric dimensional changes at high pressures and flow rates. Elastomeric fabrics that stretch and change permeability in response to higher pressures and flow rates may be able to reduce the "opening shock" during the parachute deployment phase. C1 [Gibson, Phillip W.; Desabrais, Kenneth; Godfrey, Thomas] USA, Natick Soldier Res Dev & Engn Ctr, AMSRD NSC SS MS, Natick, MA 01760 USA. RP Gibson, PW (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, AMSRD NSC SS MS, Bldg 3 Res,Room 321, Natick, MA 01760 USA. EM phillip.gibson@us.army.mil RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 9 TC 3 Z9 3 U1 0 U2 4 PU INDA PI CARY PA PO BOX 1288, CARY, NC 27512-1288 USA SN 1558-9250 J9 J ENG FIBER FABR JI J. Eng. Fiber Fabr. PY 2012 VL 7 SI SI BP 29 EP 36 PG 8 WC Materials Science, Textiles SC Materials Science GA 083JT UT WOS:000314460200006 ER PT S AU Bhat, IB Rao, SR Shintri, S Jacobs, RN AF Bhat, Ishwara B. Rao, Sunil R. Shintri, Shashidhar Jacobs, Randolph N. BE HernandezCalderon, I TI Blanket and patterned growth of CdTe on (211)Si substrates by metal-organic vapor phase epitaxy SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 9, NO 8-9 SE Physica Status Solidi C-Current Topics in Solid State Physics LA English DT Proceedings Paper CT 15th International Conference on II-VI Compounds CY AUG 21-26, 2011 CL MEXICO SP Ctr Res & Adv Studies, Nano Sem, Intercovamex, Conacyt, Riber DE metalorganic chemical vapor deposition; epitaxial lateral overgrowth; selective epitaxy; CdTe ID LATERAL OVERGROWTH; GAAS AB Metalorganic vapor phase epitaxy (MOVPE) of (211)B CdTe on (211)Si using intermediate Ge and ZnTe layers has been achieved for use as substrates for the growth of HgCdTe infrared detector materials. The best (211)B CdTe films grown in this study display a low X-ray diffraction (XRD) rocking-curve full-width-at-half-maximum (FWHM) of 64 arcs for a 12 mu m thick layer and Everson etch pit density (EPD) of 3x10(5) cm(-2). In order to reduce the threading dislocation density further, growth on patterned layer has been investigated using Si3N4 as the mask. In order to achieve selective nucleation on patterned layer, process parameters were first developed. A circular pattern was used to study the anisotropy during growth and to identify the optimum orientation for parallel stripe growth windows. The optimum growth window was then used for the growth of completely merged layers. (C) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Bhat, Ishwara B.; Rao, Sunil R.] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, 110 8th St, Troy, NY 12180 USA. [Shintri, Shashidhar] Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. [Jacobs, Randolph N.] US Army, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Bhat, IB (reprint author), Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, 110 8th St, Troy, NY 12180 USA. EM bhati@rpi.edu FU US Army STTR through Agiltron Inc. [W911NF-07-C- 0105]; Brimrose Corporation. [W911NF- 08C- 0071] FX We thank Professor Jan F. Schetzina of NC State for providing the Si3N4 coated CdTe/ Si wafers. Partial support from US Army STTR contracts W911NF-07-C- 0105 through Agiltron Inc. (Dr. Matthew Erdtmann) and W911NF- 08C- 0071 through Brimrose Corporation. Many discussions with Dr. P. Wijewarnasuriya of ARL and Dr. William Clark of ARO are appreciated. NR 14 TC 2 Z9 2 U1 1 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY SN 1862-6351 J9 PHYS STATUS SOLIDI C PY 2012 VL 9 IS 8-9 BP 1712 EP 1715 DI 10.1002/pssc.201100765 PG 4 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA BDS29 UT WOS:000314686400001 ER PT S AU Shintri, S Rao, S Schaper, C Palosz, W Trivedi, S Semendy, F Wijewarnasuriya, P Bhat, I AF Shintri, Shashidhar Rao, Sunil Schaper, Charles Palosz, Witold Trivedi, Sudhir Semendy, Fred Wijewarnasuriya, Priyalal Bhat, Ishwara BE HernandezCalderon, I TI Metalorganic vapor phase epitaxial growth of (211)B CdTe on nanopatterned (211)Si SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 9, NO 8-9 SE Physica Status Solidi C-Current Topics in Solid State Physics LA English DT Proceedings Paper CT 15th International Conference on II-VI Compounds CY AUG 21-26, 2011 CL MEXICO SP Ctr Res & Adv Studies, Nano Sem, Intercovamex, Conacyt, Riber DE CdTe epitaxy; molecular transfer lithography; dislocation reduction ID MOLECULAR-BEAM EPITAXY; HGCDTE; SI AB Low-defect density epitaxial CdTe on Si is very crucial for fabricating high performance HgCdTe IR focal planar arrays on Si. This paper discusses a novel nanopatterning technique to explore defect reduction in CdTe epitaxy on (211) Si. Nanopatterning of full 3 '' (211) Si wafers was done by growing a thin layer of thermal SiO2 and patterning by molecular transfer lithography (MxL) based on water-soluble templates. Conditions for obtaining selective Ge and CdTe were obtained in the temperature range of 575-675 degrees C and 505-520 degrees C respectively. X-ray analysis of thin CdTe films grown on these substrates gave wider full-width half-maximum (FWHM) values when compared to the layers grown on blanket (non-patterned) (211) Si, which is attributed to some patterning defects and spurious nucleation on oxide side walls. (C) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Shintri, Shashidhar] Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. [Rao, Sunil; Bhat, Ishwara] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Schaper, Charles] Transfer Devices Inc, Santa Clara, CA 95054 USA. [Palosz, Witold; Trivedi, Sudhir] Brimrose Corp America, Sparks, NY 21152 USA. [Semendy, Fred; Wijewarnasuriya, Priyalal] US Army, Res Lab, Adelphi, MD 20783 USA. RP Shintri, S (reprint author), Rensselaer Polytech Inst, Dept Engn Sci, Troy, NY 12180 USA. EM shints@rpi.edu FU US army STTR through Brimrose Corporation of America [W911NF-08-C- 0071] FX This work was partially supported by US army STTR contract W911NF-08-C- 0071 through Brimrose Corporation of America. NR 17 TC 1 Z9 1 U1 0 U2 2 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY SN 1862-6351 J9 PHYS STATUS SOLIDI C PY 2012 VL 9 IS 8-9 BP 1716 EP 1719 DI 10.1002/pssc.201100653 PG 4 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA BDS29 UT WOS:000314686400002 ER PT J AU Rushing, JF Little, DN Garg, N AF Rushing, John F. Little, Dallas N. Garg, Navneet TI Asphalt Pavement Analyzer Used to Assess Rutting Susceptibility of Hot-Mix Asphalt Designed for High Tire Pressure Aircraft SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Hot-mix asphalt (HMA) laboratory mix design is intended to determine the proportion of aggregate and binder that, when mixed and compacted under a specified effort, will withstand anticipated loading conditions. Current mix design procedures that use the Superpave (R) gyratory compactor rely on the engineering properties and volumetrics of the compacted mixture to ensure reliable performance; however, a definitive performance test does not exist. The asphalt pavement analyzer (APA) was evaluated as a tool for assessing HMA mixtures designed to perform under high tire pressure aircraft following FAA specifications. The APA used in this study was specially designed to test simulated high tire pressures of 250 psi, which are becoming more common for aircraft. Thirty-three HMA mixtures were included in the study. Each was designed with the Superpave gyratory compactor, according to preliminary criteria being developed by FAA. The study included some mixtures that contain excessive percentages of natural sand and that do not meet FAA criteria. These mixtures were included to provide relative performance for mixtures expected to exhibit premature rutting. APA testing with the high tire pressure APA resulted in rapid failure of HMA specimens compared with traditional APA testing at lower pressures. Data were analyzed, with a focus on the provision of acceptance recommendations for mixtures to support high tire pressures. A preliminary 10-mm rut depth criterion after 4,000 load cycles is recommended. C1 [Rushing, John F.] USA, Engineer Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. [Little, Dallas N.] Texas A&M Univ, Dept Civil Engn, CE TTI 603, College Stn, TX 77843 USA. [Garg, Navneet] FAA, Airport Technol R&D Branch, William J Hughes Tech Ctr, Atlantic City Int Airport, Atlantic City, NJ 08405 USA. RP Rushing, JF (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM John.F.Rushing@usace.army.mil FU FAA Airport Technology Research and Development Branch under the FAA-ERDC Interagency Agreement FX The work described in this paper was supported by the FAA Airport Technology Research and Development Branch under the FAA-ERDC Interagency Agreement. The authors thank Jeff Stein and Matt Wilson of SRA International for conducting the APA testing. The authors also thank Eyad Masad of Texas A&M University for his contributions on AIMS testing. NR 17 TC 3 Z9 3 U1 4 U2 7 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2012 IS 2296 BP 97 EP 105 DI 10.3141/2296-10 PG 9 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 083UB UT WOS:000314489600011 ER PT J AU Rindfleisch, A Antia, KD AF Rindfleisch, Aric Antia, Kersi D. BE Lilien, GL Grewal, R TI Survey research in B2B marketing: current challenges and emerging opportunities SO HANDBOOK OF BUSINESS-TO-BUSINESS MARKETING LA English DT Article; Book Chapter ID BUYER-SUPPLIER RELATIONSHIPS; COMMON METHOD VARIANCE; RESPONSE RATES; ESTIMATING NONRESPONSE; DISTRIBUTION CHANNELS; SELF-REPORTS; MAIL SURVEYS; BEHAVIOR; ORIENTATION; DESIGN C1 [Rindfleisch, Aric; Antia, Kersi D.] Univ Wisconsin Madison, Sch Business, Madison, WI 53706 USA. [Rindfleisch, Aric] Korea Univ, Seoul, South Korea. [Rindfleisch, Aric] USA, Washington, DC USA. RP Rindfleisch, A (reprint author), Univ Wisconsin Madison, Sch Business, Madison, WI 53706 USA. NR 97 TC 3 Z9 3 U1 7 U2 10 PU EDWARD ELGAR PUBLISHING LTD PI CHELTENHAM PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND BN 978-1-84980-142-3 PY 2012 BP 699 EP 714 PG 16 WC Business SC Business & Economics GA BBI97 UT WOS:000307001200037 ER PT J AU Lowe, K AF Lowe, Karl BE Murray, W Mansoor, PR TI Hybrid War in Vietnam SO HYBRID WARFARE: FIGHTING COMPLEX OPPONENTS FROM THE ANCIENT WORLD TO THE PRESENT LA English DT Article; Book Chapter C1 [Lowe, Karl] USA, Washington, DC USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA THE PITT BUILDING, TRUMPINGTON ST, CAMBRIDGE CB2 1RP, CAMBS, ENGLAND BN 978-1-107-02608-7 PY 2012 BP 254 EP 288 D2 10.1017/CBO9781139199254 PG 35 WC History SC History GA BDF05 UT WOS:000312992000010 ER PT J AU Kucik, P Pate-Cornell, E AF Kucik, Paul Pate-Cornell, Elisabeth TI Counterinsurgency: A Utility-Based Analysis of Different Strategies SO MILITARY OPERATIONS RESEARCH LA English DT Article AB An insurgency is a structured movement intended to overthrow a constituted government through armed conflict. The ongoing insurgency in Afghanistan has challenged the United States' armed forces for more than 10 years. With more than a dozen known insurgencies being waged throughout the world, insurgency is a challenge that the US is likely to face for the foreseeable future. Because every insurgency is different, no single policy or resource allocation rule can be applied successfully to all situations. Even within a given country, the insurgent threat varies across local areas, and within a single local area, over time. Additionally, measuring the current level of insurgency can be problematic because of the complexity of interactions among the various contributing factors, political and socioeconomic. This paper presents a model of the dynamic interaction between an insurgent group and a government in order to evaluate strategies designed to defeat (or control) an insurgency. This model represents an alternate game at the level of a village. It includes probabilistic submodels of actions from both the insurgent leader and the government policymaker, in which each side's decisions affect the uncertainties faced by the other. In this framework, we use the rational decision analysis model to describe the choices made by both sides. At each step or time unit, each decision maker chooses the course of action (COA) that maximizes his or her expected utility until the end of that particular time unit. The moves and countermoves are analyzed as a game between these two parties and that game is simulated over a given time horizon. The risk associated with a government strategy is computed as the probability that after a certain number of time units, the considered region is still below a given threshold of stability. It is characterized by the chances that the expected government utility is below the corresponding level at that time. An application to a village in the Philippines showed that for the specific strategy over a three-year time window, the chosen option had not yielded considerable improvement to the stability of the area. Because insurgency varies from place to place, the importance of this research is not so much in the specific results described in this illustration as in the framework that it presents for the analysis of insurgency. The goal is to identify policies that lead more quickly to stabilization of a local area. This objective of this paper is to better anticipate the long-term effects of different strategic options given the possible responses of the insurgents. C1 [Kucik, Paul] US Mil Acad, West Point, NY 10996 USA. [Pate-Cornell, Elisabeth] Stanford Univ, Stanford, CA 94305 USA. RP Kucik, P (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Paul.Kucik@usma.edu; mep@stanford.edu NR 17 TC 0 Z9 0 U1 0 U2 12 PU MILITARY OPERATIONS RESEARCH SOC PI ALEXANDRIA PA 1703 N BEAUREGARD ST, STE 450, ALEXANDRIA, VA 22311-1717 USA SN 0275-5823 J9 MIL OPER RES JI Mil. Oper. Res. PY 2012 VL 17 IS 4 BP 5 EP 23 DI 10.5711/1082598317405 PG 19 WC Operations Research & Management Science SC Operations Research & Management Science GA 079WU UT WOS:000314203700001 ER PT S AU Clements, CM Buller, MJ Welles, AP Tharion, WJ AF Clements, Cynthia M. Buller, Mark J. Welles, Alexander P. Tharion, William J. GP IEEE TI Real Time Gait Pattern Classification from Chest Worn Accelerometry During a Loaded Road March SO 2012 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 34th Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBS) CY AUG 28-SEP 01, 2012 CL San Diego, CA SP IEEE, Engn Med & Biol Soc (EMBS), CAS, SMC, PubMed, MEDLINE ID HUMAN WALKING; STABILITY; MOVEMENT AB Accelerometers, whether in smart phones or wearable physiological monitoring systems are becoming widely used to identify movement and activities of free living individuals. Although there has been much work in applying computationally intensive methods to this problem, this paper focuses on developing a real-time gait analysis approach that is intuitive, requires no individual calibration, can be extended to complex gait analysis, and can readily be adopted by ambulatory physiological monitors for use in real time. Chest-mounted tri-axial accelerometry data were collected from sixty-one male U. S. Army Ranger candidates engaged in an 8 or 12 mile loaded (35 Kg packs) timed road march. The pace of the road march was such that volunteers needed to both walk and run. To provide intuitive features we examined the periodic patterns generated from 4s periods of movement from the vertical and longitudinal accelerometer axes. Applying the "eigenfaces" face recognition approach we used Principal Components Analysis to find a single basis vector from 10% of the data (n=6) that could distinguish patterns of walk and run with a classification rate of 95% and 90% (n=55) respectively. Because these movement features are based on a gridded frequency count, the method is applicable for use by body-worn microprocessors. C1 [Clements, Cynthia M.; Buller, Mark J.; Welles, Alexander P.; Tharion, William J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Clements, CM (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. EM Cynthia.clements@us.army.mil NR 18 TC 0 Z9 0 U1 1 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4577-1787-1 J9 IEEE ENG MED BIO PY 2012 BP 364 EP 367 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BDH78 UT WOS:000313296500089 ER PT J AU Shakarian, P Dickerson, JP Subrahmanian, VS AF Shakarian, Paulo Dickerson, John P. Subrahmanian, V. S. TI Adversarial Geospatial Abduction Problems SO ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY LA English DT Article DE Abduction; spatial reasoning; Algorithms; Experimentation; Theory AB Geospatial Abduction Problems (GAPs) involve the inference of a set of locations that "best explain" a given set of locations of observations. For example, the observations might include locations where a serial killer committed murders or where insurgents carried out Improvised Explosive Device (IED) attacks. In both these cases, we would like to infer a set of locations that explain the observations, for example, the set of locations where the serial killer lives/works, and the set of locations where insurgents locate weapons caches. However, unlike all past work on abduction, there is a strong adversarial component to this; an adversary actively attempts to prevent us from discovering such locations. We formalize such abduction problems as a two-player game where both players (an "agent" and an "adversary") use a probabilistic model of their opponent (i.e., a mixed strategy). There is asymmetry as the adversary can choose both the locations of the observations and the locations of the explanation, while the agent (i.e., us) tries to discover these. In this article, we study the problem from the point of view of both players. We define reward functions axiomatically to capture the similarity between two sets of explanations (one corresponding to the locations chosen by the adversary, one guessed by the agent). Many different reward functions can satisfy our axioms. We then formalize the Optimal Adversary Strategy (OAS) problem and the Maximal Counter-Adversary strategy (MCA) and show that both are NP-hard, that their associated counting complexity problems are #P-hard, and that MCA has no fully polynomial approximation scheme unless P=NP. We show that approximation guarantees are possible for MCA when the reward function satisfies two simple properties (zero-starting and monotonicity) which many natural reward functions satisfy. We develop a mixed integer linear programming algorithm to solve OAS and two algorithms to (approximately) compute MCA; the algorithms yield different approximation guarantees and one algorithm assumes a monotonic reward function. Our experiments use real data about IED attacks over a 21-month period in Baghdad. We are able to show that both the MCA algorithms work well in practice; while MCA-GREEDY-MONO is both highly accurate and slightly faster than MCA-LS, MCA-LS (to our surprise) always completely and correctly maximized the expected benefit to the agent while running in an acceptable time period. C1 [Shakarian, Paulo] US Mil Acad, West Point, NY 10996 USA. [Dickerson, John P.; Subrahmanian, V. S.] Univ Maryland, College Pk, MD 20742 USA. RP Shakarian, P (reprint author), US Mil Acad, West Point, NY 10996 USA. EM Paulo@shakarian.net FU AFOSR [FA95500610405]; ARO [W911NF0910206, W911NF0910525] FX Some of the authors of this article were funded in part by AFOSR grant FA95500610405 and ARO grants W911NF0910206 and W911NF0910525. NR 28 TC 1 Z9 1 U1 1 U2 3 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 2157-6904 J9 ACM T INTEL SYST TEC JI ACM Trans. Intell. Syst. Technol. PY 2012 VL 3 IS 2 AR 34 DI 10.1145/2089094.2089110 PG 35 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA 073SR UT WOS:000313763300016 ER PT J AU Del Favero, G Sosa, S Pelin, M D'Orlando, E Florio, C Lorenzon, P Poli, M Tubaro, A AF Del Favero, Giorgia Sosa, Silvio Pelin, Marco D'Orlando, Elisabetta Florio, Chiara Lorenzon, Paola Poli, Mark Tubaro, Aurelia TI Sanitary problems related to the presence of Ostreopsis spp. in the Mediterranean Sea: a multidisciplinary scientific approach SO ANNALI DELL ISTITUTO SUPERIORE DI SANITA LA English DT Article DE Ostreopsis; palytoxin (PLTX); acute toxicity; myotoxicity; cutaneous toxicity ID NORTHERN ADRIATIC SEA; OF-THE-ART; CF. OVATA; PUTATIVE PALYTOXIN; OSTREOCIN-D; OVATOXIN-A; STRUCTURE ELUCIDATION; MASS-SPECTROMETRY; TYRRHENIAN SEA; TOXIN PROFILE AB The increased presence of potentially toxic microalgae in the Mediterranean area is a matter of great concern. Since the end of the last century, microalgae of the genus Ostreopsis have been detected more and more frequently in the Italian coastal waters. The presence of Ostreopsis spp. has been accompanied by the presence of previously undetected marine biotoxins (palytoxins) into the ecosystem with the increased possibility of human exposure. In response to the urgent need for toxicity characterization of palytoxin and its congeners, an integrated study encompassing both in vitro and in vivo methods was performed. C1 [Del Favero, Giorgia; Sosa, Silvio; Pelin, Marco; D'Orlando, Elisabetta; Florio, Chiara; Lorenzon, Paola; Tubaro, Aurelia] Univ Trieste, Dipartimento Sci Vita, I-34127 Trieste, Italy. [Poli, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Tubaro, A (reprint author), Univ Trieste, Dipartimento Sci Vita, Via A Valerio 6, I-34127 Trieste, Italy. EM tubaro@units.it FU Italian Ministry of Education University and Research [PRIN2009JS5YX9_002]; Regione Friuli-Venezia Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori di elevata sensibilita per la determinazione delle tossine di alghe nelle acque e nei prodotti ittici del Friuli-Venezia Giulia - Senstox") FX This work was supported by the Italian Ministry of Education University and Research (PRIN2009JS5YX9_002) and Regione Friuli-Venezia Giulia, Direzione Risorse Rurali, Agroalimentari e Forestali (Progetto "Kit e biosensori di elevata sensibilita per la determinazione delle tossine di alghe nelle acque e nei prodotti ittici del Friuli-Venezia Giulia - Senstox"). The authors are grateful to G. Honsell (University of Udine), to G. Decorti (University of Trieste), to R. Cefalo (GeoSNav, University of Trieste) and to A. Penna (University of Urbino) for their stimulating support. NR 75 TC 9 Z9 10 U1 2 U2 17 PU EDITRICE KURTIS S R L PI MILAN PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY SN 0021-2571 J9 ANN I SUPER SANITA JI Ann. Ist. Super. Sanita PY 2012 VL 48 IS 4 BP 407 EP 414 DI 10.4415/ANN_12_04_08 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 076CQ UT WOS:000313934500008 PM 23247137 ER PT J AU Wood, MD Bostrom, A Convertino, M Kovacs, D Linkov, I AF Wood, Matthew D. Bostrom, Ann Convertino, Matteo Kovacs, Daniel Linkov, Igor TI A Moment of Mental Model Clarity: Response to Jones et al. 2011 SO ECOLOGY AND SOCIETY LA English DT Editorial Material DE cognitive science; expert elicitation; mental model; natural resource management; stakeholder engagement C1 [Wood, Matthew D.; Linkov, Igor] USA, Corps Engineers Res & Dev Ctr, Washington, DC USA. [Wood, Matthew D.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Bostrom, Ann] Univ Washington, Seattle, WA 98195 USA. [Convertino, Matteo] Univ Florida, Gainesville, FL 32611 USA. RP Wood, MD (reprint author), USA, Corps Engineers Res & Dev Ctr, Washington, DC USA. OI Wood, Matthew/0000-0002-1140-1526 NR 11 TC 3 Z9 3 U1 2 U2 10 PU RESILIENCE ALLIANCE PI WOLFVILLE PA ACADIA UNIV, BIOLOGY DEPT, WOLFVILLE, NS B0P 1X0, CANADA SN 1708-3087 J9 ECOL SOC JI Ecol. Soc. PY 2012 VL 17 IS 4 AR 7 DI 10.5751/ES-05122-170407 PG 3 WC Ecology; Environmental Studies SC Environmental Sciences & Ecology GA 069EF UT WOS:000313417400025 ER PT J AU Jiang, J You, BJ Liu, E Apte, A Yarina, TR Myers, TE Lee, JS Francesconi, SC O'Guinn, ML Tsertsvadze, N Vephkhvadze, N Babuadze, G Sidamonidze, K Kokhreidze, M Donduashvili, M Onashvili, T Ismayilov, A Agayev, N Aliyev, M Muttalibov, N Richards, AL AF Jiang, Ju You, Brian J. Liu, Evan Apte, Anisha Yarina, Tamasin R. Myers, Todd E. Lee, John S. Francesconi, Stephen C. O'Guinn, Monica L. Tsertsvadze, Nikoloz Vephkhvadze, Nino Babuadze, Giorgi Sidamonidze, Ketevan Kokhreidze, Maka Donduashvili, Marina Onashvili, Tinatin Ismayilov, Afrail Agayev, Nigar Aliyev, Mubariz Muttalibov, Nizam Richards, Allen L. TI Development of three quantitative real-time PCR assays for the detection of Rickettsia raoultii, Rickettsia slovaca, and Rickettsia aeschlimannii and their validation with ticks from the country of Georgia and the Republic of Azerbaijan SO TICKS AND TICK-BORNE DISEASES LA English DT Article DE R. raoultii; R. slovaca; R. aeschlimannii; Quantitative real-time PCR assays; The country of Georgia ID FEVER GROUP RICKETTSIA; POLYMERASE-CHAIN-REACTION; SPOTTED-FEVER; ORIENTIA-TSUTSUGAMUSHI; BORNE RICKETTSIOSES; HYALOMMA-MARGINATUM; DISEASE; INFECTION; LYMPHADENOPATHY; IDENTIFICATION AB A previous surveillance study of human pathogens within ticks collected in the country of Georgia showed a relatively high infection rate for Rickettsia raoultii, R. slovaca, and R. aeschlimannii. These 3 spotted fever group rickettsiae are human pathogens: R. raoultii and R. slovaca cause tick-borne lymphadenopathy (TIBOLA), and R. aeschlimannii causes an infection characterized by fever and maculopapular rash. Three quantitative real-time polymerase chain reaction (qPCR) assays, Rraoul, Rslov, and Raesch were developed and optimized to detect R. raoultii, R. slovaca, and R. aeschlimannii, respectively, by targeting fragments of the outer membrane protein B gene (ompB) using species-specific molecular beacon or TaqMan probes. The 3 qPCR assays showed 100% specificity when tested against a rickettsiae DNA panel (n = 20) and a bacteria DNA panel (n = 12). The limit of detection was found to be at least 3 copies per reaction for all assays. Validation of the assays using previously investigated tick nucleic acid preparations, which included Rickettsia-free tick samples, tick samples that contain R. raoultii, R. slovaca, R. aeschlimannii, and other Rickettsia spp., gave 100% sensitivity for all 3 qPCR assays. In addition, a total of 65 tick nucleic acid preparations (representing 259 individual ticks) collected from the country of Georgia and the Republic of Azerbaijan in 2009 was tested using the 3 qPCR assays. R. raoultii, R. slovaca, and R. aeschlimannii were not detected in any ticks (n = 31) from the Republic of Azerbaijan, but in the ticks from the country of Georgia (n = 228) the minimal infection rate for R. raoultii and R. slovaca in Dermacentor marginatus was 10% and 4%, respectively, and for R. aeschlimannii in Haemaphysalis sulcata and Hyalomma spp. it was 1.9% and 20%, respectively. Published by Elsevier GmbH. C1 [Richards, Allen L.] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Lee, John S.; O'Guinn, Monica L.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Tsertsvadze, Nikoloz; Babuadze, Giorgi; Sidamonidze, Ketevan] Natl Ctr Dis Control, Tbilisi, Rep of Georgia. [Vephkhvadze, Nino; Kokhreidze, Maka; Donduashvili, Marina; Onashvili, Tinatin] Lab Minist Agr, Tbilisi, Rep of Georgia. [Ismayilov, Afrail; Agayev, Nigar] Republican Antiplague Stn, Baku, Azerbaijan. [Aliyev, Mubariz] Inst Med Prophylaxis, Baku, Azerbaijan. [Muttalibov, Nizam] Republican Hyg & Epidemiol Ctr, Baku, Azerbaijan. RP Richards, AL (reprint author), USN, Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Allen.Richards@med.navy.mil RI Valle, Ruben/A-7512-2013 FU Defense Threat Reduction Agency [B0017 60000.000.0.B0017] FX Funding provided by the Defense Threat Reduction Agency, Work unit # B0017 60000.000.0.B0017. NR 28 TC 9 Z9 10 U1 0 U2 7 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 1877-959X J9 TICKS TICK-BORNE DIS JI Ticks Tick-Borne Dis. PY 2012 VL 3 IS 5-6 BP 326 EP 330 DI 10.1016/j.ttbdis.2012.10.004 PG 5 WC Infectious Diseases; Microbiology; Parasitology SC Infectious Diseases; Microbiology; Parasitology GA 078EK UT WOS:000314081000014 PM 23182543 ER PT J AU Shakarian, P Subrahmanian, VS Sapino, ML AF Shakarian, Paulo Subrahmanian, V. S. Sapino, Maria Luisa TI GAPs: Geospatial Abduction Problems SO ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY LA English DT Article DE Theory; Algorithms; Experimentation; Abduction; complexity analysis; heuristic algorithms ID COMPLEXITY; ALGORITHMS AB There are many applications where we observe various phenomena in space (e.g., locations of victims of a serial killer), and where we want to infer "partner" locations (e.g., the location where the killer lives) that are geospatially related to the observed phenomena. In this article, we define geospatial abduction problems (GAPs for short). We analyze the complexity of GAPs, develop exact and approximate algorithms (often with approximation guarantees) for these problems together with analyses of these algorithms, and develop a prototype implementation of our GAP framework. We demonstrate accuracy of our algorithms on a real world data set consisting of insurgent IED (improvised explosive device) attacks against U.S. forces in Iraq (the observations were the locations of the attacks, while the "partner" locations we were trying to infer were the locations of IED weapons caches). C1 [Shakarian, Paulo; Subrahmanian, V. S.] Univ Maryland, College Pk, MD 20742 USA. [Sapino, Maria Luisa] Univ Turin, Turin, Italy. RP Shakarian, P (reprint author), US Mil Acad, West Point, NY 10996 USA. EM paulo@shakarian.net; vs@cs.umd.edu; mlsapino@di.unito.it FU AFOSR [FA95500610405]; ARO [W911NF0910206, W911NF0910525] FX Some of the authors of this article were funded in part by AFOSR grant FA95500610405 and ARO grants W911NF0910206 and W911NF0910525. NR 38 TC 0 Z9 0 U1 1 U2 1 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA SN 2157-6904 J9 ACM T INTEL SYST TEC JI ACM Trans. Intell. Syst. Technol. PY 2012 VL 3 IS 1 AR 7 DI 10.1145/2036264.2036271 PG 27 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems SC Computer Science GA 073SQ UT WOS:000313763200007 ER PT S AU Pradhan, NR Byrd, AR Ogden, FL Hendrickx, JMH AF Pradhan, Nawa Raj Byrd, Aaron R. Ogden, Fred L. Hendrickx, Jan M. H. BE Neale, CMU Cosh, MH TI SEBAL evapotranspiration estimates for the improvement of distributed hydrological model runoff and soil moisture predictions SO REMOTE SENSING AND HYDROLOGY SE IAHS Publication LA English DT Proceedings Paper CT Remote Sensing and Hydrology Symposium CY SEP 27-30, 2010 CL Jackson Hole, WY SP IAHS, Int Commiss Remote Sens DE soil moisture; evapotranspiration; GSSHA; SEBAL; distributed hydrologic modelling; hydrograph; runoff ID OPTICAL IMAGERY AB Uncertainties in the initial distribution of soil moisture negatively impact predictability of runoff and future soil moisture state when using physics-based distributed-parameter hydrological models. In this study we tested a novel method for identifying the soil moisture distribution required to initialize the Gridded Surface/Subsurface Hydrologic Analysis (GSSHA) model. Surface Energy Balance Algorithms for Land (SEBAL)-derived actual evapotranspiration (ET) estimates are used in conjunction with an empirical relationship between the ratio of actual to potential ET and the soil moisture on a pixel-by-pixel basis. The resulting soil moisture estimates were used to initialize a GSSHA simulation of the 3000 km(2) Kishwaukee River watershed in Illinois. We observed that the derived initial soil moisture distribution improved GSSHA simulation of soil moisture dynamics, reducing the uncertainty in runoff estimation. C1 [Pradhan, Nawa Raj; Byrd, Aaron R.] USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. [Hendrickx, Jan M. H.] New Mexico Inst Min & Technol, Dept Earth & Environm Sci, Socorro, NM 8780 USA. RP Pradhan, NR (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 12 TC 1 Z9 1 U1 0 U2 10 PU INT ASSOC HYDROLOGICAL SCIENCES PI WALLINGFORD PA INST OF HYDROLOGY, WALLINGFORD OX10 8BB, ENGLAND SN 0144-7815 BN 978-1-907161-27-8 J9 IAHS-AISH P PY 2012 VL 352 BP 435 EP + PG 3 WC Remote Sensing; Water Resources SC Remote Sensing; Water Resources GA BDK60 UT WOS:000313596500100 ER PT J AU Priddy, LP Rushing, TW AF Priddy, Lucy P. Rushing, Timothy W. TI Development of Laboratory Testing Protocol for Rapid-Setting Cementitious Material for Airfield Pavement Repairs SO TRANSPORTATION RESEARCH RECORD LA English DT Article AB Many commercial off-the-shelf products for repairing portland cement concrete (PCC) pavements provide short set times, high early strengths, and the durability to withstand aircraft traffic. Twenty-five rapid-setting cementitious materials were investigated through laboratory and field evaluations to determine their suitability for repairing critical PCC airfield pavements. Standard laboratory tests were performed to characterize the properties of the materials and provide a protocol for assessing their suitability for field repairs. Criteria for using rapid-setting cementitious materials for repairing airfield pavements were published in 2008 by the U.S. Air Force. The criteria, based on laboratory and full-scale testing, allowed users to reduce the risk of premature failure of repairs by omitting unacceptable materials from their list of potential repair materials. The American Society of Testing and Materials published a similar test protocol in 2009. On the basis of a comparison of these two certification procedures and knowledge gained through field experience, the Air Force selection protocol was further updated in 2010 to improve the material selection process. The laboratory test methods used to develop the selection protocol along with the results from the material investigations are discussed in this paper. C1 [Priddy, Lucy P.; Rushing, Timothy W.] USA, Engineer Res & Dev Ctr, CEERD GM A, Vicksburg, MS 39180 USA. RP Priddy, LP (reprint author), USA, Engineer Res & Dev Ctr, CEERD GM A, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM lucy.p.priddy@usace.army.mil FU U.S. Air Force Civil Engineer Support Agency FX The tests described and the resulting data, unless otherwise noted, were obtained from research conducted under the U.S. Air Force Airfield Pavement Material Certification Program sponsored by the U.S. Air Force Civil Engineer Support Agency and performed at the U.S. Army Engineer Research and Development Center. Permission to publish this information was granted by the director, Geotechnical and Structures Laboratory. NR 17 TC 2 Z9 2 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0361-1981 J9 TRANSPORT RES REC JI Transp. Res. Record PY 2012 IS 2290 BP 89 EP 98 DI 10.3141/2290-12 PG 10 WC Engineering, Civil; Transportation; Transportation Science & Technology SC Engineering; Transportation GA 066NZ UT WOS:000313228800013 ER PT S AU Dogaru, T Le, C AF Dogaru, Traian Le, Calvin GP IEEE TI Simulation of a Polarimetric Radar Imaging System Using Realistic Antenna Patterns SO 2012 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation CY JUL 08-14, 2012 CL Chicago, IL SP Inst Electr Electron Engineers, IEEE Antennas & Propaga Soc AB In this paper we analyze the impact of coupling the polarimetric characteristics of antennas and targets on a radar system response and performance. In particular, we show that the cross-polarized fields radiated by antennas can have a significant impact on a polarimetric radar imaging system that involves wide-angle integration. As a numerical example, we apply this method to the problem of through-the-wall detection of small weapons based on polarimetric differences between images. The simulation results demonstrate a reduction in the weapon detection scheme performance when the radar antenna cross-polarization suppression drops under a certain limit. C1 [Dogaru, Traian; Le, Calvin] USA, Res Lab, Adelphi, MD 20783 USA. RP Dogaru, T (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4673-0462-7 J9 IEEE ANTENNAS PROP PY 2012 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BDB29 UT WOS:000312442300033 ER PT S AU Donohoe, JP Fairley, JR Lynch, LN AF Donohoe, J. Patrick Fairley, Josh R. Lynch, Larry N. GP IEEE TI Coupling of Underground Objects to Antennas and Transmission Lines at Antiresonance SO 2012 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation CY JUL 08-14, 2012 CL Chicago, IL SP Inst Electr Electron Engineers, IEEE Antennas & Propagat Soc AB The changes in input impedance for a simple antenna or transmission line located over a soil containing a conducting object are examined near antiresonance. The near-field coupling of the underground object to the antenna or transmission line is investigated using the complex Poynting vector in order to identify the contribution of traveling and/or standing waves. C1 [Donohoe, J. Patrick] Mississippi State Univ, Dept Elect & Comp Engn, Box 9571, Mississippi State, MS 39762 USA. [Fairley, Josh R.; Lynch, Larry N.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Donohoe, JP (reprint author), Mississippi State Univ, Dept Elect & Comp Engn, Box 9571, Mississippi State, MS 39762 USA. EM donohoe@ece.msstate.edu; Josh.R.Fairley@us.army.mil; Larry.N.Lynch@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4673-0462-7 J9 IEEE ANTENNAS PROP PY 2012 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BDB29 UT WOS:000312442302063 ER PT S AU Farmer, TJ Darwish, A Viveiros, E Hung, HA Zaghloul, ME AF Farmer, Thomas J. Darwish, Ali Viveiros, Edward Hung, H. Alfred Zaghloul, Mona E. GP IEEE TI 94 GHz Power Amplifier Device Architecture in SiGe for Active Phased Arrays SO 2012 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation CY JUL 08-14, 2012 CL Chicago, IL SP Inst Electr Electron Engineers, IEEE Antennas & Propagat Soc AB This paper discusses the first implementation of the High Voltage / High Power (HiVP) Amplifier Architecture in silicon in the W-band. Designed and laid out using a commercial 120 nm SiGe HBT BiCMOS process, a saturated output power of 9.7 dBm, gain of 7.7 dB, and a PAE of 12.0 % in an area of 0.20 mm(2) have been achieved at 94 GHz. Small signal gain > 10 dB has been simulated from 50 GHz to 110 GHz. The intent of this paper is to introducce an amplifier device architecture intended for inclusion in transmitter / receiver ICs that would become a part of an active phased array operating in the W-band. In addition, provide designers with a simplified simulation technique, layout examples, and an architecture with a small layout footprint over classical techniques employed in current research. C1 [Farmer, Thomas J.; Darwish, Ali; Viveiros, Edward; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA. [Zaghloul, Mona E.] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA. RP Farmer, TJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4673-0462-7 J9 IEEE ANTENNAS PROP PY 2012 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BDB29 UT WOS:000312442300111 ER PT S AU Lee, EN Hall, R Katulka, G Duncan, K Barry, E Pa, P Mirotznick, M Patel, P Holmes, L AF Lee, Eric N. Hall, Rex Katulka, Gary Duncan, Kate Barry, Edwin Pa, Peter Mirotznick, Mark Patel, Parimal Holmes, Larry GP IEEE TI Modeling, Simulation, and Measurement of a Transparent Armor Embedded Meshed Microstrip Antenna SO 2012 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation CY JUL 08-14, 2012 CL Chicago, IL SP Inst Electr Electron Engineers, IEEE Antennas & Propagat Soc AB This paper presents the design and performance of a transparent armor embedded meshed microstrip antenna. In order to reduce opacity of the metallization, a sparse mesh pattern was chosen for the radiating patch. The pattern was subsequently enlarged and translated onto the ground plane, thus reducing the visual footprint of the antenna. After initial simulations, all un-embedded antenna and mesh dimensions were optimized for a specific operating frequency. A prototype patch antenna was then screen printed onto a single layer of glass, and characterized in an anechoic chamber. The antenna was subsequently embedded into a multilayered transparent armor stack and its parameters re-measured. Experiments confirm that the single layer design maintains typical patch antenna performance while reducing visual footprint and in comparison, the multi-layer embedded antenna reduces overall performance and must be compensated for a priori. C1 [Lee, Eric N.; Hall, Rex; Katulka, Gary] USA, Guidance Technol Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Duncan, Kate; Barry, Edwin] S & TCD CERDEC, Antenna Technol & Anal Branch, Aberdeen Proving Ground, MD 21005 USA. [Pa, Peter; Mirotznick, Mark] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 20742 USA. [Patel, Parimal] US Army Res Lab, Ceram & Transparent Mat Branch, Aberdeen Proving Ground, MD 21005 USA. [Holmes, Larry] US Army Res Lab, Composites & Hybrid Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Lee, EN (reprint author), USA, Guidance Technol Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 2 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4673-0462-7 J9 IEEE ANTENNAS PROP PY 2012 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BDB29 UT WOS:000312442302022 ER PT S AU Liao, DH AF Liao, DaHan GP IEEE TI Ground Surface Scattering and Clutter Suppression in Ground-Penetrating Radar Applications SO 2012 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation CY JUL 08-14, 2012 CL Chicago, IL SP Inst Electr Electron Engineers, IEEE Antennas & Propaga Soc AB A scattering and imaging, clutter characterization and suppression study is carried out to demonstrate the feasibility of sensing buried targets in a terrain environment with a rough ground surface. The investigation is pertinent to detection performance analysis and prediction for a vehicle-based, ultra-wideband, ground-penetrating radar system. In the electromagnetic domain, the scattering response of the terrain scene is computed with a parallelized finite-difference time-domain solver; subsequent multistatic image formation is obtained with a time-reversal based approach. In the image domain, the distribution of the ground clutter is analyzed, and a statistical polarimetric clutter reduction method is applied to improve the signal-to-background ratio. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Liao, DH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 4 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4673-0462-7 J9 IEEE ANTENNAS PROP PY 2012 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BDB29 UT WOS:000312442300032 ER PT S AU McMichael, IT Mirotznik, M Zaghloul, AI AF McMichael, Ian T. Mirotznik, Mark Zaghloul, Amir I. GP IEEE TI A Method for Determining Optimal EBG Reflection Phase for Low Profile Antennas SO 2012 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM (APSURSI) SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT IEEE International Symposium on Antennas and Propagation CY JUL 08-14, 2012 CL Chicago, IL SP Inst Electr Electron Engineers, IEEE Antennas & Propaga Soc AB A novel analytical method for determining the optimal reflection phase of an electromagnetic band gap (EBG) ground plane to match a low profile antenna is introduced. Image theory is used to incorporate the near field coupling between a dipole antenna and the ground plane. The optimal EBG reflection phase is obtained over a frequency band of interest and is related to the antenna's return loss for a given antenna height above the EBG. The resulting reflection phase can be used as a reference for designing an EBG ground plane that is well matched to the antenna without time consuming iterative full wave numerical simulations. Numerical modeling results are compared to the optimal return loss derived from the analytical method to validate the design process. C1 [McMichael, Ian T.] USA, RDECOM CERDEC NVSED, Ft Belvoir, VA 22060 USA. RP McMichael, IT (reprint author), USA, RDECOM CERDEC NVSED, Ft Belvoir, VA 22060 USA. NR 6 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4673-0462-7 J9 IEEE ANTENNAS PROP PY 2012 PG 2 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BDB29 UT WOS:000312442301317 ER EF