FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Dickens, CPTJF Kilcoyne, CPTKG Giuliani, MAJJ Owens, LTCBD AF Dickens, C. P. T. Jonathan F. Kilcoyne, C. P. T. Kelly G. Giuliani, M. A. J. Jeffrey Owens, L. T. C. Brett D. TI Circumferential Labral Tears Resulting From a Single Anterior Glenohumeral Instability Event A Report of 3 Cases in Young Athletes SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE shoulder; instability; dislocation; subluxation; labral tear ID SHOULDER DISLOCATIONS; RECURRENT DISLOCATION; ARTHROSCOPIC STABILIZATION; GLENOID LABRUM; LESIONS; 1ST-TIME; JOINT; PATHOLOGY; REPAIR C1 [Dickens, C. P. T. Jonathan F.; Kilcoyne, C. P. T. Kelly G.; Giuliani, M. A. J. Jeffrey; Owens, L. T. C. Brett D.] Keller Army Hosp, West Point, NY 10996 USA. RP Owens, LTCBD (reprint author), Keller Army Hosp, 900 Washington Rd, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 33 TC 1 Z9 1 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD JAN PY 2012 VL 40 IS 1 BP 213 EP 217 DI 10.1177/0363546511423005 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 873CA UT WOS:000298857200027 ER PT J AU Louie, A VanScoy, BD Heine, HS Liu, WG Abshire, T Holman, K Kulawy, R Brown, DL Drusano, GL AF Louie, Arnold VanScoy, Brian D. Heine, Henry S., III Liu, Weiguo Abshire, Terry Holman, Kari Kulawy, Robert Brown, David L. Drusano, George L. TI Differential Effects of Linezolid and Ciprofloxacin on Toxin Production by Bacillus anthracis in an In Vitro Pharmacodynamic System SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PROTECTIVE ANTIGEN; CLINDAMYCIN; ANTIBODIES; INFECTION; MODEL AB Bacillus anthracis causes anthrax. Ciprofloxacin is a gold standard for the treatment of anthrax. Previously, using the non-toxinproducing Delta Sterne strain of B. anthracis, we demonstrated that linezolid was equivalent to ciprofloxacin for reducing the total ( vegetative and spore) bacterial population. With ciprofloxacin therapy, the total population consisted of spores. With linezolid therapy, the population consisted primarily of vegetative bacteria. Linezolid is a protein synthesis inhibitor, while ciprofloxacin is not. Since toxins are produced only by vegetative B. anthracis, the effect of linezolid and ciprofloxacin on toxin production is of interest. The effect of simulated clinical regimens of ciprofloxacin and linezolid on the vegetative and spore populations and on toxin production was examined in an in vitro pharmacodynamic model over 15 days by using the toxin-producing Sterne strain of B. anthracis. Ciprofloxacin and linezolid reduced the total Sterne population at similar rates. With ciprofloxacin therapy, the total Sterne population consisted of spores. With linezolid therapy,>90% of the population was vegetative B. anthracis. With ciprofloxacin therapy, toxin was first detectable at 3 h and remained detectable for at least 5 h. Toxin was never detected with linezolid therapy. Ciprofloxacin and linezolid reduced the total Sterne population at similar rates. However, the B. anthracis population was primarily spores with ciprofloxacin therapy and was primarily vegetative bacteria with linezolid therapy. Toxin production was detected for at least 5 h with ciprofloxacin therapy but was never detected with linezolid treatment. Linezolid may have an advantage over ciprofloxacin for the treatment of B. anthracis infections. C1 [Louie, Arnold; VanScoy, Brian D.; Heine, Henry S., III; Liu, Weiguo; Kulawy, Robert; Brown, David L.; Drusano, George L.] Univ Florida, Inst Therapeut Innovat, Albany, NY USA. [Heine, Henry S., III; Abshire, Terry; Holman, Kari] USA, Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Louie, A (reprint author), Univ Florida, Inst Therapeut Innovat, Albany Campus, Albany, NY USA. EM alouie@medicine.ufl.edu FU National Institute of Allergy and Infectious Diseases [P01AI060908] FX This work was supported by grant number P01AI060908 from the National Institute of Allergy and Infectious Diseases. NR 22 TC 7 Z9 7 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JAN PY 2012 VL 56 IS 1 BP 513 EP 517 DI 10.1128/AAC.05724-11 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 866TB UT WOS:000298404900061 PM 22064542 ER PT J AU Moores, LK King, CS Holley, AB AF Moores, Lisa K. King, Christopher S. Holley, Aaron B. TI All That Gutters Is Not Gold in Pursuing the Diagnosis of Pulmonary Embolism Response SO CHEST LA English DT Letter C1 [Moores, Lisa K.] Uniformed Serv Univ Hlth Sci, Off Student Affairs, Dept Med, Bethesda, MD 20814 USA. [King, Christopher S.] William Beaumont Army Med Ctr, Pulm & Crit Care Med Serv, El Paso, TX 79920 USA. [Holley, Aaron B.] Walter Reed Army Med Ctr, Pulm Crit Care & Sleep Med Serv, Washington, DC 20307 USA. RP Moores, LK (reprint author), Uniformed Serv Univ Hlth Sci, Off Student Affairs, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM lmoores@usuhs.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD JAN PY 2012 VL 141 IS 1 BP 277 EP 278 DI 10.1378/chest.11-2285 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 874FW UT WOS:000298941800050 ER PT J AU Killgore, WDS Grugle, NL Balkin, TJ AF Killgore, William D. S. Grugle, Nancy L. Balkin, Thomas J. TI Gambling When Sleep Deprived: Don't Bet on Stimulants SO CHRONOBIOLOGY INTERNATIONAL LA English DT Article DE Decision-making; Iowa Gambling Task; Risk-taking; Sleep deprivation; Stimulants ID PSYCHOMOTOR VIGILANCE TEST; DECISION-MAKING; PREFRONTAL CORTEX; EMOTIONAL BRAIN; RISK-TAKING; ONE NIGHT; 24 H; DEPRIVATION; CAFFEINE; PERFORMANCE AB Recent evidence suggests that sleep deprivation leads to suboptimal decision-making on the Iowa Gambling Task (IGT), a pattern that appears to be unaffected by moderate doses of caffeine. It is not known whether impaired decision-making could be reversed by higher doses of caffeine or by other stimulant countermeasures, such as dextroamphetamine or modafinil. Fifty-four diurnally active healthy subjects completed alternate versions of the IGT at rested baseline, at 23 and 46 h awake, and following a night of recovery sleep. After 44 h awake, participants received a double-blind dose of caffeine (600 mg), dextroamphetamine (20 mg), modafinil (400 mg), or placebo. At baseline, participants showed a normal pattern of advantageous performance, whereas both sleep-deprived sessions were associated with suboptimal decision-making on the IGT. Following stimulant administration on the second night of sleep deprivation, groups receiving caffeine, dextroamphetamine, or modafinil showed significant reduction in subjective sleepiness and improvement in psychomotor vigilance, but decision-making on the IGT remained impaired for all stimulants and did not differ from placebo. Decision-making returned to normal following recovery sleep. These findings are consistent with prior research showing that sleep deprivation leads to suboptimal decision-making on some types of tasks, particularly those that rely heavily on emotion processing regions of the brain, such as the ventromedial prefrontal cortex. Moreover, the deficits in decision-making were not reversed by commonly used stimulant countermeasures, despite restoration of psychomotor vigilance and alertness. These three stimulants may restore some, but not all, aspects of cognitive functioning during sleep deprivation. (Author correspondence: Killgore@mclean.harvard.edu) C1 [Killgore, William D. S.] Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, Belmont, MA 02478 USA. [Killgore, William D. S.; Grugle, Nancy L.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Killgore, WDS (reprint author), Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM Killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 40 TC 24 Z9 24 U1 2 U2 18 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0742-0528 J9 CHRONOBIOL INT JI Chronobiol. Int. PY 2012 VL 29 IS 1 BP 43 EP 54 DI 10.3109/07420528.2011.635230 PG 12 WC Biology; Physiology SC Life Sciences & Biomedicine - Other Topics; Physiology GA 873CP UT WOS:000298858800006 PM 22217100 ER PT J AU Peachman, KK Li, Q Matyas, GR Shivachandra, SB Lovchik, J Lyons, RC Alving, CR Rao, VB Rao, M AF Peachman, Kristina K. Li, Qin Matyas, Gary R. Shivachandra, Sathish B. Lovchik, Julie Lyons, Rick C. Alving, Carl R. Rao, Venigalla B. Rao, Mangala TI Anthrax Vaccine Antigen-Adjuvant Formulations Completely Protect New Zealand White Rabbits against Challenge with Bacillus anthracis Ames Strain Spores SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID CYTOTOXIC T-LYMPHOCYTES; HEAT-LABILE ENTEROTOXIN; SKIN DENDRITIC CELLS; TRANSCUTANEOUS IMMUNIZATION; INHALATION ANTHRAX; ESCHERICHIA-COLI; IMMUNE-RESPONSES; BACTERIOPHAGE-T4; TOXIN; IMMUNOGENICITY AB In an effort to develop an improved anthrax vaccine that shows high potency, five different anthrax protective antigen (PA)-adjuvant vaccine formulations that were previously found to be efficacious in a nonhuman primate model were evaluated for their efficacy in a rabbit pulmonary challenge model using Bacillus anthracis Ames strain spores. The vaccine formulations include PA adsorbed to Alhydrogel, PA encapsulated in liposomes containing monophosphoryl lipid A, stable liposomal PA oil-in-water emulsion, PA displayed on bacteriophage T4 by the intramuscular route, and PA mixed with Escherichia coli heat-labile enterotoxin administered by the needle-free transcutaneous route. Three of the vaccine formulations administered by the intramuscular or the transcutaneous route as a three-dose regimen induced 100% protection in the rabbit model. One of the formulations, liposomal PA, also induced significantly higher lethal toxin neutralizing antibodies than PA-Alhydrogel. Even 5 months after the second immunization of a two-dose regimen, rabbits vaccinated with liposomal PA were 100% protected from lethal challenge with Ames strain spores. In summary, the needle-free skin delivery and liposomal formulation that were found to be effective in two different animal model systems appear to be promising candidates for next-generation anthrax vaccine development. C1 [Peachman, Kristina K.; Matyas, Gary R.; Alving, Carl R.; Rao, Mangala] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. [Peachman, Kristina K.] Henry M Jackson Fdn Advancement Mil Med, US Mil HIV Res Program, Rockville, MD USA. [Li, Qin; Shivachandra, Sathish B.; Rao, Venigalla B.] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA. [Lovchik, Julie; Lyons, Rick C.] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA. RP Rao, M (reprint author), Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. EM mrao@hivresearch.org FU HMJ Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense [W81XWH-07-2-0067]; U.S. NIAID, NIH, under NIAID [U01-AI056443] FX This research was supported by a cooperative agreement (W81XWH-07-2-0067) between the HMJ Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense. The research was funded in part by the U.S. NIAID, NIH, under NIAID grant U01-AI056443 (to V.B.R.). NR 39 TC 13 Z9 15 U1 0 U2 9 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JAN PY 2012 VL 19 IS 1 BP 11 EP 16 DI 10.1128/CVI.05376-11 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 870NA UT WOS:000298675000003 PM 22089245 ER PT J AU Barcia, AM Kozlowski, EJ Tokish, JM AF Barcia, Anthony M. Kozlowski, Erick J. Tokish, John M. TI Return to Sport After Meniscal Repair SO CLINICS IN SPORTS MEDICINE LA English DT Article DE Meniscus; Meniscal repair; Rehabilitation; Therapy; Return to sport ID ACCELERATED REHABILITATION; IMMOBILIZATION; MENISCECTOMY; RECOVERY; TEARS; KNEE AB Preservation of meniscal function is among the most important goals in knee surgery. Loss of this function after meniscal injury and treatment with meniscectomy has long been recognized to play a major role in the deterioration in knee function and the development of degenerative joint disease. Therefore, surgeons have become more and more aggressive with meniscal repair and adjunctive procedures to promote healing in meniscal surgery. C1 [Barcia, Anthony M.; Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Kozlowski, Erick J.] USAF Acad, Colorado Springs, CO 80840 USA. RP Barcia, AM (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM anthony.m.barcia@us.army.mil NR 26 TC 3 Z9 3 U1 3 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-5919 J9 CLIN SPORT MED JI Clin. Sports Med. PD JAN PY 2012 VL 31 IS 1 BP 155 EP + DI 10.1016/j.csm.2011.08.010 PG 13 WC Sport Sciences SC Sport Sciences GA 865JW UT WOS:000298308200012 PM 22108665 ER PT J AU Batra, RC Gopinath, G Zheng, JQ AF Batra, R. C. Gopinath, G. Zheng, J. Q. TI Damage and failure in low energy impact of fiber-reinforced polymeric composite laminates SO COMPOSITE STRUCTURES LA English DT Article DE Damage; Failure; Elastoplastic deformations; Impact ID PROGRESSIVE DAMAGE; MODEL; DELAMINATION; PREDICTION; BEHAVIOR; LOADS AB We analyze the damage initiation, damage progression, and failure during 3-dimensional (3-D) elastoplastic deformations of a fiber reinforced polymeric laminated composite impacted by a low speed rigid sphere, and compare computed results with experimental findings available in the literature. Damage is assumed to initiate when one of Hashin's failure criteria is satisfied, and its evolution is modeled by an empirical relation proposed by Matzenmiller, Lubliner and Taylor. The transient nonlinear problem is solved by the finite element method (FEM). Contributions of the work include considering damage in 3-D rather than plane stress deformations of a laminated structure and elasto-plastic deformations of the composite. This has been accomplished by developing a user defined subroutine and implementing it in the FE software ABAQUS. From strains supplied by ABAQUS the material subroutine uses a micromechanics approach based on the method of cells and values of material parameters of constituents to calculate average stresses in an FE, and checks for Hashin's failure criteria. If damage has initiated in the material, the subroutine evaluates the damage developed, computes resulting stresses, and provides them to ABAQUS. The damage evolved at a material point is not allowed to decrease during unloading. The delamination failure mode is simulated by using the cohesive zone model available in ABAQUS. The computed time histories of the axial load acting on the impactor are found to agree well with the experimental ones available in the literature, and various damage and failure modes agree qualitatively with those observed in tests. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Batra, R. C.; Gopinath, G.] Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, Blacksburg, VA 24061 USA. [Zheng, J. Q.] USA, Program Execut Off, Haymarket, VA 20169 USA. RP Batra, RC (reprint author), Virginia Polytech Inst & State Univ, Dept Engn Sci & Mech, M-C 0219, Blacksburg, VA 24061 USA. EM rbatra@vt.edu FU Army Research Laboratory (ARL); Office of Naval Research [N00014-1-06-0567]; [W911NF-06-2-0014] FX This research was sponsored by the Army Research Laboratory (ARL) and was accomplished under Cooperative Agreement Number W911NF-06-2-0014. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing official policies, either expressed or implied, of the ARL or the US Government. The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. The work was also partially supported by the Office of Naval Research Grant N00014-1-06-0567 to Virginia Tech with Dr. Y.D.S. Rajapakse as the program manager. Views expressed herein are those of the authors and neither of the funding agencies nor of their institutions. NR 40 TC 21 Z9 28 U1 2 U2 31 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JAN PY 2012 VL 94 IS 2 BP 540 EP 547 DI 10.1016/j.compstruct.2011.08.015 PG 8 WC Materials Science, Composites SC Materials Science GA 866EF UT WOS:000298362600025 ER PT J AU Chandra, Y Stanciulescu, I Eason, T Spottswood, M AF Chandra, Yenny Stanciulescu, Ilinca Eason, Thomas Spottswood, Michael TI Numerical pathologies in snap-through simulations SO ENGINEERING STRUCTURES LA English DT Article DE Snap-through; Finite element; Curved beam; Solid (continuum) elements; Structural elements; Time integrators; Numerical pathologies ID NONLINEAR DYNAMICS; CONSERVING ALGORITHMS; ENERGY; MOMENTUM; ELASTODYNAMICS AB Aircraft structures operating in severe environments may experience snap-through, causing the curvature on part or all of the structure to invert inducing fatigue damage. This paper examines the performance of beam and continuum nonlinear finite element formulations in conjunction with several popular implicit time stepping algorithms to assess the accuracy and stability of numerical simulations of snap-through events. Limitations of the structural elements are identified and we provide examples of interaction between spatial and temporal discretizations that affect the robustness of the overall scheme and impose strict limits on the size of the time step. These limitations need to be addressed in future works in order to develop accurate, robust and efficient simulation methods for response prediction of structures encountering extreme environments. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Chandra, Yenny; Stanciulescu, Ilinca] Rice Univ, Dept Civil & Environm Engn, Houston, TX 77005 USA. [Eason, Thomas; Spottswood, Michael] USA, Res Lab, Struct Sci Ctr, Wright Patterson AFB, OH USA. RP Stanciulescu, I (reprint author), Rice Univ, Dept Civil & Environm Engn, 6100 Main St, Houston, TX 77005 USA. EM ilinca@rice.edu OI Stanciulescu, Ilinca/0000-0003-4515-0363 FU AFOSR [FA9550-09-1-0201] FX The work has been funded in part by AFOSR under the Grant No. FA9550-09-1-0201. This support is greatly appreciated. NR 21 TC 6 Z9 6 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0141-0296 J9 ENG STRUCT JI Eng. Struct. PD JAN PY 2012 VL 34 BP 495 EP 504 DI 10.1016/j.engstruct.2011.10.013 PG 10 WC Engineering, Civil SC Engineering GA 877AZ UT WOS:000299150200044 ER PT J AU Nijak, GM Geary, JR Larson, SL Talley, JW AF Nijak, Gary M., Jr. Geary, Joseph R. Larson, Steven L. Talley, Jeffrey W. TI Autonomous, Wireless In-Situ Sensor (AWISS) for Rapid Warning of Escherichia coli Outbreaks in Recreational and Source Waters SO ENVIRONMENTAL ENGINEERING SCIENCE LA English DT Article DE pathogens; autonomous; water quality; optics; recreation; E. coli; sensor ID BETA-GLUCURONIDASE; HYDROLYSIS AB An autonomous, wireless, in-situ sensor (AWISS) was demonstrated for the detection of Escherichia coli. A prototype battery-powered optical AWISS, consisting of a miniature spectrophotometer, monitored the changes in fluorescence intensity that occur when the E. coli-synthesized beta-glucuronidase enzyme hydrolyzes the reagent's glycosidic bond, releasing fluorophores into solution. Laboratory testing with the prototype sensor showed the AWISS was capable of detecting low concentrations (<100 colony forming units [CFU]/100 mL) in less than eight hours. Higher concentrations (>5000 CFU/100 mL), indicative of a possible combined sewage discharge, could be detected in under one hour. A seven-day demonstration utilized the prototype sensor to sample and record the bacterial water quality of the St. Joseph River in South Bend, Indiana. Every six hours a new sample was drawn into a custom-designed stop-flow reaction chamber and injected with a soluble reagent. A wireless transmitter sent intensity data to a remote monitoring station. The deployment produced 19 individual sampling events, of which 15 were compared to culture methods approved by the U. S. Environmental Protection Agency (USEPA). Four samples were drawn in the middle of the night and not verified. Of the 15 verified samples, 13 correctly identified the presence or absence of an E. coli concentration defined as significant by the USEPA and Indiana Department of Environmental Management (IDEM) thresholds of 125 CFU/100 mL. C1 [Talley, Jeffrey W.] Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA. [Nijak, Gary M., Jr.] Environm Technol Solut LLC, Gilbert, AZ USA. [Geary, Joseph R.] USA, Leavenworth, KS USA. [Larson, Steven L.] USA, Corps Engineers, Environm Chem Branch, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Talley, JW (reprint author), Johns Hopkins Univ, Dept Geog & Environm Engn, Ames Hall 313,3400 N Charles St, Baltimore, MD 21218 USA. EM jtalley2@jhu.edu FU Defense Advanced Research Products Agency (U.S. Department of Defense, Arlington, VA) [N00164-07-C-8510] FX We would also like to thank the Defense Advanced Research Products Agency (U.S. Department of Defense, Arlington, VA) for the CRANE Naval Surface Warfare Center grant (grant #N00164-07-C-8510). NR 25 TC 4 Z9 4 U1 1 U2 12 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1092-8758 J9 ENVIRON ENG SCI JI Environ. Eng. Sci. PD JAN PY 2012 VL 29 IS 1 BP 64 EP 69 DI 10.1089/ees.2011.0148 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 875LJ UT WOS:000299031100009 ER PT J AU Handy, RD Cornelis, G Fernandes, T Tsyusko, O Decho, A Sabo-Attwood, T Metcalfe, C Steevens, JA Klaine, SJ Koelmans, AA Horne, N AF Handy, Richard D. Cornelis, Geert Fernandes, Teresa Tsyusko, Olga Decho, Alan Sabo-Attwood, Tara Metcalfe, Chris Steevens, Jeffery A. Klaine, Stephen J. Koelmans, Albert A. Horne, Nina TI Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Review DE Nanoparticle; Ecotoxicity test method; Validation; Bioaccumulation ID NEMATODE CAENORHABDITIS-ELEGANS; TITANIUM-DIOXIDE NANOPARTICLES; WALLED CARBON NANOTUBES; ZINC-OXIDE NANOPARTICLES; SILVER NANOPARTICLES; RAINBOW-TROUT; IN-VITRO; MANUFACTURED NANOPARTICLES; ONCORHYNCHUS-MYKISS; DAPHNIA-MAGNA AB Ecotoxicology research is using many methods for engineered nanomaterials (ENMs), but the collective experience from researchers has not been documented. This paper reports the practical issues for working with ENMs and suggests nano-specific modifications to protocols. The review considers generic practical issues, as well as specific issues for aquatic tests, marine grazers, soil organisms, and bioaccumulation studies. Current procedures for cleaning glassware are adequate, but electrodes are problematic. The maintenance of exposure concentration is challenging, but can be achieved with some ENMs. The need to characterize the media during experiments is identified, but rapid analytical methods are not available to do this. The use of sonication and natural/synthetic dispersants are discussed. Nano-specific biological endpoints may be developed for a tiered monitoring scheme to diagnose ENM exposure or effect. A case study of the algal growth test highlights many small deviations in current regulatory test protocols that are allowed (shaking, lighting, mixing methods), but these should be standardized for ENMs. Invertebrate (Daphnia) tests should account for mechanical toxicity of ENMs. Fish tests should consider semistatic exposure to minimize wastewater and animal husbandry. The inclusion of a benthic test is recommended for the base set of ecotoxicity tests with ENMs. The sensitivity of soil tests needs to be increased for ENMs and shortened for logistics reasons; improvements include using Caenorhabditis elegans, aquatic media, and metabolism endpoints in the plant growth tests. The existing bioaccumulation tests are conceptually flawed and require considerable modification, or a new test, to work for ENMs. Overall, most methodologies need some amendments, and recommendations are made to assist researchers. Environ. Toxicol. Chem. 2012;31:1531. (C) 2011 SETAC C1 [Handy, Richard D.] Univ Plymouth, Ecotoxicol Res & Innovat Ctr, Sch Biomed & Biol Sci, Plymouth PL4 8AA, Devon, England. [Cornelis, Geert] Univ Adelaide, Sch Agr Food & Wine, Adelaide, SA 5005, Australia. [Fernandes, Teresa] Napier Univ, Fac Hlth Life & Social Sci, Edinburgh EH14 1DJ, Midlothian, Scotland. [Tsyusko, Olga] Univ Kentucky, Dept Plant & Soil Sci, Lexington, KY USA. [Decho, Alan; Sabo-Attwood, Tara] Univ S Carolina, Dept Environm Hlth Sci, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. [Metcalfe, Chris] Trent Univ, Peterborough, ON K9J 7B8, Canada. [Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Klaine, Stephen J.] Clemson Univ, Inst Environm Toxicol, Clemson, SC USA. [Koelmans, Albert A.] Wageningen Univ, Wageningen, Netherlands. [Koelmans, Albert A.] IMARES, Ijmuiden, Netherlands. [Horne, Nina] Univ Calif Berkeley, Goldman Sch Publ Policy, Ctr Integrated Nanoscale Mat, Berkeley, CA 94720 USA. RP Handy, RD (reprint author), Univ Plymouth, Ecotoxicol Res & Innovat Ctr, Sch Biomed & Biol Sci, Plymouth PL4 8AA, Devon, England. EM rhandy@plymouth.ac.uk RI Cornelis, Geert/F-7044-2010; OI Cornelis, Geert/0000-0003-0078-6798; Tsyusko, Olga/0000-0001-8196-1062; Koelmans, Albert/0000-0001-7176-4356; Fernandes, Teresa/0000-0002-8541-598X FU Environmental Protection Agency; Arcadis-US; Clemson University Institute of Environmental Toxicology; U.S. Environmental Protection Agency [EF-0830083]; National Science Foundation [RD-83457401] FX This paper evolved from discussions held at a SETAC-endorsed Technical Workshop held at Clemson University in August, 2010. The workshop was sponsored by the Environmental Protection Agency, Arcadis-US, and the Clemson University Institute of Environmental Toxicology.; O. Tsyusko received financial support in part from the U.S. Environmental Protection Agency (EF-0830083) and the National Science Foundation (RD-83457401). NR 115 TC 131 Z9 135 U1 11 U2 254 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-7268 EI 1552-8618 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2012 VL 31 IS 1 SI SI BP 15 EP 31 DI 10.1002/etc.706 PG 17 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 860ED UT WOS:000297930700003 PM 22002667 ER PT J AU Mitrano, DM Lesher, EK Bednar, A Monserud, J Higgins, CP Ranville, JF AF Mitrano, Denise M. Lesher, Emily K. Bednar, Anthony Monserud, Jon Higgins, Christopher P. Ranville, James F. TI Detecting nanoparticulate silver using single-particle inductively coupled plasma-mass spectrometry SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nanoparticle; Quantification; Wastewater; Silver ID ENGINEERED NANOPARTICLES; COLLOID ANALYSIS; ENVIRONMENTAL EXPOSURE; NANOSILVER TOXICITY; ESCHERICHIA-COLI; RISK; NANOMATERIALS; BEHAVIOR; BACTERIA; SULFIDE AB The environmental prevalence of engineered nanomaterials, particularly nanoparticulate silver (AgNP), is expected to increase substantially. The ubiquitous use of commercial products containing AgNP may result in their release to the environment, and the potential for ecological effects is unknown. Detecting engineered nanomaterials is one of the greatest challenges in quantifying their risks. Thus, it is imperative to develop techniques capable of measuring and characterizing exposures, while dealing with the innate difficulties of nanomaterial detection in environmental samples, such as low-engineered nanomaterial concentrations, aggregation, and complex matrices. Here the authors demonstrate the use of inductively coupled plasmamass spectrometry, operated in a single-particle counting mode (SP-ICP-MS), to detect and quantify AgNP. In the present study, two AgNP products were measured by SP-ICP-MS, including one of precisely manufactured size and shape, as well as a commercial AgNP-containing health food product. Serial dilutions, filtration, and acidification were applied to confirm that the method detected particles. Differentiation of dissolved and particulate silver (Ag) is a feature of the technique. Analysis of two wastewater samples demonstrated the applicability of SP-ICP-MS at nanograms per liter Ag concentrations. In this pilot study, AgNP was found at 100 to 200ng/L in the presence of 50 to 500ng/L dissolved Ag. The method provides the analytical capability to monitor Ag and other metal and metal oxide nanoparticles in fate, transport, stability, and toxicity studies using a commonly available laboratory instrument. Rapid throughput and element specificity are additional benefits of SP-ICP-MS as a measurement tool for metal and metal oxide engineered nanoparticles. Environ. Toxicol. Chem. 2012;31:115121. (C) 2011 SETAC C1 [Mitrano, Denise M.; Lesher, Emily K.; Higgins, Christopher P.; Ranville, James F.] Colorado Sch Mines, Golden, CO 80401 USA. [Bednar, Anthony] USA, Engineer Res & Dev Ctr, Environm Labs, Vicksburg, MS USA. [Monserud, Jon] Univ Colorado, Boulder, CO 80309 USA. RP Ranville, JF (reprint author), Colorado Sch Mines, Golden, CO 80401 USA. EM jranvill@mines.edu RI Higgins, Christopher/B-1836-2010; OI Higgins, Christopher/0000-0001-6220-8673; ranville, james/0000-0002-4347-4885 FU U.S. Army Engineer Research and Development Center [W912HZ-09-P0163]; U.S. EPA [RD-83332401-0] FX This work was supported by the U.S. Army Engineer Research and Development Center Cooperative (agreement W912HZ-09-P0163) and the U.S. EPA - Science to Achieve Results (STAR) Program (grant RD-83332401-0). NR 39 TC 132 Z9 136 U1 22 U2 210 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JAN PY 2012 VL 31 IS 1 SI SI BP 115 EP 121 DI 10.1002/etc.719 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 860ED UT WOS:000297930700013 PM 22012920 ER PT J AU Rungruang, B Miller, A Richard, SD Hamilton, CA Rodriguez, N Bookman, MA Maxwell, GL Krivak, TC Horowitz, NS AF Rungruang, Bunja Miller, Austin Richard, Scott D. Hamilton, Chad A. Rodriguez, Noah Bookman, Michael A. Maxwell, G. Larry Krivak, Thomas C. Horowitz, Neil S. TI Should stage IIIC ovarian cancer be further stratified by intraperitoneal vs. retroperitoneal only disease?: A Gynecologic Oncology Group study SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Ovarian cancer; Lymphadenopathy; FIGO staging ID PRIMARY CYTOREDUCTIVE SURGERY; NODE INVOLVEMENT; CARCINOMA; SURVIVAL; LYMPHADENECTOMY; METASTASIS; IMPACT; TRIAL AB Objective. To examine whether clinical outcomes varied with intraperitoneal (IP) and/or retroperitoneal (RP) involvement in stage IIIC epithelial ovarian cancer (EOC) patients with microscopic residual disease after cytoreduction. Methods. Retrospective review was performed for EOC patients enrolled in Gynecologic Oncology Group (GOG)-182 who underwent primary cytoreduction to microscopic residual disease. Patients were divided into 3 groups: stage IIIC by lymphadenopathy with <2 cm IF spread (RP): >2 cm IP spread and negative nodes (IP/RP-): and >2 cm IP dissemination and positive lymphadenopathy (IP/RP+). Product-limit and multivariate proportional hazards modeling were used. Results. Analyses included 417 stage IIIC women who underwent primary cytoreduction with lymphadenectomy to microscopic residual. There were 203, 123, and 91 in the RP, IP/RP-, and IP/RP+ groups, respectively. IP/RP+ and IP/RP- were associated with worse progression-free survival (PFS) (Hazard Ratio (HR) 1.68, 95% confidence interval (CI) 1.23-2.30: HR 1.38, 95% CI 1.04-1.84) vs. RP only. IP/RP+ was associated with worse overall survival (OS) (HR 1.79, 95% CI 1.24-2.57) while IP/RP- trended towards worse OS (HR 1.21, 95% CI 0.85-1.73) vs. RP only. Median PFS for IP/RP+ and IP/RP- groups was 21 and 29 months, respectively, vs. 48 months in the RP group (p = 0.0007) and median OS of 63 and 79 months vs. "not reached," respectively (p = 0.0038). Conclusions. Among EOC patients surgically cytoreduced to microscopic residual disease, those upstaged to IIIC by retroperitoneal involvement demonstrated significant improvement in PFS and OS compared to patients with intraperitoneal tumor, suggesting that these women may represent a unique subset of FIGO stage IIIC patients. (C) 2011 Elsevier Inc. All rights reserved. C1 [Rungruang, Bunja; Richard, Scott D.; Krivak, Thomas C.] UPMC, Magee Womens Hosp, Dept Obstet & Gynecol, Div Gynecol Oncol, Pittsburgh, PA USA. [Miller, Austin] Roswell Pk Canc Inst, Stat & Data Ctr, Gynecol Oncol Grp, Buffalo, NY 14263 USA. [Hamilton, Chad A.; Maxwell, G. Larry] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Rodriguez, Noah; Horowitz, Neil S.] Brigham & Womens Hosp, Div Gynecol Oncol, Boston, MA 02115 USA. [Bookman, Michael A.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA. RP Horowitz, NS (reprint author), Massachusetts Gen Hosp, 75 Francis St, Boston, MA 02115 USA. EM nhorowitz@partners.org FU National Cancer Institute [CA 27469, CA 37517] FX This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group (COG) Administrative Office (CA 27469) and the Gynecologic Oncology Group Statistical Office (CA 37517). The following Gynecologic Oncology Group member institutions participated in the primary treatment studies: University of Alabama at Birmingham, Oregon Health Sciences University, Duke University Medical Center, Abington Memorial Hospital, University of Rochester Medical Center, Walter Reed Army Medical Center, Wayne State University, University of Minnesota Medical School, University of Southern California at Los Angeles, University of Mississippi Medical Center, Colorado Gynecologic Oncology Group P.C., University of California at Los Angeles, University of Washington. University of Pennsylvania Cancer Center, University of Miami School of Medicine, Milton S. Hershey Medical Center, Georgetown University Hospital, University of Cincinnati, University of North Carolina School of Medicine. University of Iowa Hospitals and Clinics. University of Texas Southwestern Medical Center at Dallas, Indiana University School of Medicine, Wake Forest University School of Medicine, Albany Medical College, University of California Medical Center at Irvine, Tufts-New England Medical Center, Rush-Presbyterian-St. Luke's Medical Center, University of Kentucky, Eastern Virginia Medical School, The Cleveland Clinic Foundation, Johns Hopkins Oncology Center, State University of New York at Stony Brook, Eastern Pennsylvania GYN/ONC Center, P.C., Southwestern Oncology Group, Washington University School of Medicine, Memorial Sloan-Kettering Cancer Center, Columbus Cancer Council, University of Massachusetts Medical School, Fox Chase Cancer Center, Medical University of South Carolina, Women's Cancer Center, University of Oklahoma. University of Virginia Health Sciences Center, University of Chicago, University of Arizona Health Science Center, Tacoma General Hospital, Eastern Collaborative Oncology Group, Thomas Jefferson University Hospital, Case Western Reserve University, and Tampa Bay Cancer Consortium. NR 25 TC 3 Z9 5 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JAN PY 2012 VL 124 IS 1 BP 53 EP 58 DI 10.1016/j.ygyno.2011.09.024 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 864BV UT WOS:000298212900012 PM 22032836 ER PT J AU Anderson, W Barrows, M Lopez, F Rogers, S Ortiz-Coffie, A Norman, D Hodges, J McDonald, K Barnes, D McCall, S Johnson, AD Ceremuga, TE AF Anderson, Wesley Barrows, Mark Lopez, Fernando Rogers, Sara Ortiz-Coffie, Adriana Norman, David Hodges, Jonathan McDonald, Keith Barnes, Devon McCall, Suzanne Johnson, Arthur Don Ceremuga, Thomas E. TI Investigation of the Anxiolytic Effects of Naringenin, a Component of Mentha Aquatica, in the Male Sprague-Dawley Rat SO HOLISTIC NURSING PRACTICE LA English DT Article DE anxiolysis; elevated plus maze; mentha aquatica; mint; naringenin; Sprague-Dawley rat ID MEDICINE; PLANTS AB This was a prospective, randomized, between-subjects experimental study to investigate the anxiolytic effects of naringenin, a component of mentha aquatica, and its potential interaction with the benzodiazepine binding site on the gamma-aminobutyric acid (GABA(A)) receptor in the rat. Fifty-five rats were assigned to one of 5 groups with 11 rats per group: control, naringenin, midazolam, midazolam with naringenin, and flumazenil with naringenin. The elevated plus maze measured the behavioral components of anxiety and motor movements. Our data suggest that naringenin does not produce anxiolysis by modulation of the GABA(A) receptor; however, the findings indicate that naringenin decreases motor movements (P < .05). C1 [Anderson, Wesley; Barrows, Mark; Lopez, Fernando; Rogers, Sara; Ortiz-Coffie, Adriana; Norman, David; Hodges, Jonathan; McDonald, Keith; Barnes, Devon; McCall, Suzanne; Johnson, Arthur Don; Ceremuga, Thomas E.] USA, Grad Program Anesthesia Nursing, Washington, DC USA. RP Ceremuga, TE (reprint author), AMEDDC&S Nursing Sci, 3490 Forage Rd,Ste 112, Ft Sam Houston, TX 78234 USA. EM Thomas.ceremuga@amedd.army.mil FU American Association of Nurse Anesthetists (AANA) Foundation; Brooke Army Medical Center Department of Clinical Investigation FX The authors are grateful for the generous funding by the American Association of Nurse Anesthetists (AANA) Foundation and Brooke Army Medical Center Department of Clinical Investigation, which supported this study. NR 24 TC 6 Z9 6 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0887-9311 J9 HOLIST NURS PRACT JI Holist. Nurs. Pract. PD JAN-FEB PY 2012 VL 26 IS 1 BP 52 EP 57 DI 10.1097/HNP.0b013e31823c003a PG 6 WC Integrative & Complementary Medicine; Nursing SC Integrative & Complementary Medicine; Nursing GA 863DQ UT WOS:000298143400007 PM 22157509 ER PT J AU Lawson, K Alvarez, G Bayne, SB Veliadis, V Ha, HC Urciuoli, D El-Hinnawy, N Borodulin, P Scozzie, C AF Lawson, K. Alvarez, G. Bayne, S. B. Veliadis, V. Ha, H. C. Urciuoli, D. El-Hinnawy, N. Borodulin, P. Scozzie, C. TI Hard-Switch Stressing of Vertical-Channel Implanted-Gate SiC JFETs SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Bidirectional; fault isolation; four quadrants; JFET; normally ON (N-ON); vertical channel; 1200 V; 4H-SiC AB A requirement for the commercialization of power SiC transistors is their long-term reliable operation under the hard-switching conditions encountered in the field. Normally ON 1200-V vertical-channel implanted-gate SiC JFETs, designed for high-power bidirectional (four-quadrant) solid-state-circuit-breaker applications, were repetitively hard switched from a 150-V blocking state to an ON-state current in excess of eight times the JFET's 250-W/cm(2) rated current. The JFETs were fabricated in seven photolithographic levels with a single masked ion implantation forming the p(+) gates and guard rings and no epitaxial regrowth. The hard-switch testing was performed using an RLC circuit capable of currents in excess of 200 A with a rise time of 150 A/mu s. In this circuit, energy initially stored in the capacitor is discharged to the resistor through the JFET under test. The JFET hard-switch stressing included 1000 shots at each temperature of 25 degrees C, 50 degrees C, 100 degrees C, and 150 degrees C and at each repetition rate of 1, 5, 10, and 100 Hz for a total of 16 000 shots. Peak energies and powers dissipated by the JFET were 7.5 mJ and 9 kW, respectively. JFET conduction and blocking-voltage characteristics remain unchanged after 16 000 pulsed hard-switching events, which is indicative of reliable operation and excellent JFET suitability for nondegrading repeated bidirectional high surge-current fault isolation. C1 [Lawson, K.; Alvarez, G.; Bayne, S. B.] Texas Tech Univ, Lubbock, TX 79409 USA. [Veliadis, V.; Ha, H. C.; El-Hinnawy, N.; Borodulin, P.] Northrop Grumman Elect Syst, Linthicum, MD 21090 USA. [Urciuoli, D.; Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Lawson, K (reprint author), Texas Tech Univ, Lubbock, TX 79409 USA. EM kevin.lawson@ttu.edu; guillermo.alvarez@ttu.edu; stephen.bayne@ttu.edu; victor.veliadis@ngc.com; hanh.ha@ngc.com; damian.urciuoli@us.army.mil; nabil.elhinnawy@ngc.com; pavel.borodulin@ngc.com; charles.scozzie@us.army.mil FU U.S. Army Research Laboratory FX This work was supported by the U.S. Army Research Laboratory. The review of this letter was arranged by Editor S.-H. Ryu. NR 13 TC 11 Z9 12 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD JAN PY 2012 VL 33 IS 1 BP 86 EP 88 DI 10.1109/LED.2011.2172183 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 866KT UT WOS:000298380300028 ER PT J AU Motes, D Keena, J Womack, K Stefani, F Crawford, M AF Motes, D. Keena, J. Womack, K. Stefani, F. Crawford, M. TI Thermal Analysis of High-Energy Railgun Tests SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Railguns AB This paper describes temperature measurements made on the high-energy medium-caliber launcher at the Institute for Advanced Technology. Simulations performed in Maxwell 3-D and E-Physics showed that Joule heating from current diffusing into the rails accounts for most of the temperature rise in the conductors. Temporal skin effects increase thermal dissipation significantly over what would be expected by the ohmic losses under fully diffused conditions. Based on this analysis, Joule heating is the overwhelmingly dominant source of heating in low-speed tests. As the velocity of the armature increases, Joule heating remains the dominant source of heat; however, additional mechanisms-which may include frictional heating, arcing energy, aluminum deposition, and temperature-dependent properties-are required to more satisfactorily explain the temperature profile obtained. C1 [Motes, D.; Keena, J.; Stefani, F.; Crawford, M.] Univ Texas Austin, Inst Adv Technol, Austin, TX 78759 USA. [Keena, J.] USA, Washington, DC 20301 USA. [Womack, K.] USN, Washington, DC 20350 USA. RP Motes, D (reprint author), Univ Texas Austin, Inst Adv Technol, Austin, TX 78759 USA. EM motes@iat.utexas.edu; keena@iat.utexas.edu; womack.kristofer@gmail.com; stefani@iat.utexas.edu; crawford@iat.utexas.edu FU U.S. Army Research Laboratory [W911QX-07-D-0002] FX The authors would like to thank M. Simmons, P. Snowden, J. Goutier, J. Hudson, and B. Hummel for their invaluable assistance during the experiments. The authors would like to also thank Dr. J. Mallick for his advice about the finite-element calculations. The research reported in this paper was performed in connection with the U.S. Army Research Laboratory under Contract Number W911QX-07-D-0002. The views and conclusions contained in this paper are those of the authors and should not be interpreted as presenting the official policies or position, either expressed or implied, of the U. S. Army Research Laboratory or the U. S. Government unless so designated by other authorized documents. Citation of manufacturers or trade names does not constitute an official endorsement or approval of the use thereof. The U. S. Government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation hereon. NR 9 TC 3 Z9 6 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JAN PY 2012 VL 40 IS 1 BP 124 EP 130 DI 10.1109/TPS.2011.2174375 PG 7 WC Physics, Fluids & Plasmas SC Physics GA 874WY UT WOS:000298990000018 ER PT J AU Prewett, MS Elliott, LR Walvoord, AG Coovert, MD AF Prewett, Matthew S. Elliott, Linda R. Walvoord, Ashley G. Coovert, Michael D. TI A Meta-Analysis of Vibrotactile and Visual Information Displays for Improving Task Performance SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS LA English DT Article DE Load management; multimodal sensors; performance evaluation; tactile sensors ID SPATIAL DISORIENTATION; TACTILE; FEEDBACK; ENVIRONMENT; SIGNALS; MODELS AB Many studies have investigated the effect of vibrotactile cues on task performance, but a wide range of cue and task types have made findings difficult to interpret without a quantitative synthesis. This report addresses that need by reviewing the effectiveness of vibrotactile cues in a meta-analysis of 45 studies. When added to a baseline task or to existing visual cues, vibrotactile cues enhanced task performance. When vibrotactile cues replaced visual cues; however, some effects were attenuated and others moderated by cue information complexity. To summarize such moderating effects, vibrotactile alerts are an effective replacement for visual alerts, but vibrotactile direction cues are not effective when replacing visual direction cues. This meta-analysis of vibrotactile applications underscores the benefits of vibrotactile and multimodal displays, highlights conditions in which vibrotactile cues are particularly effective, and identifies areas in need of further investigation. C1 [Prewett, Matthew S.] Cent Michigan Univ, Dept Psychol, Mt Pleasant, MI 48859 USA. [Elliott, Linda R.] USA, Army Res Lab, Human Res & Engn Directorate, Infantry Ctr, Ft Benning, GA 31905 USA. [Walvoord, Ashley G.] Verizon Wireless, Baton Rouge, LA 70802 USA. [Coovert, Michael D.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. RP Prewett, MS (reprint author), Cent Michigan Univ, Dept Psychol, Mt Pleasant, MI 48859 USA. EM prewe1ms@cmich.edu; linda.r.elliott@us.army.mil; Ashley.Walvoord@verizonwireless.com; coovert@luna.cas.usf.edu FU [DAAD19-01-C-0065] FX This work was supported by Government under Contract DAAD19-01-C-0065, task order 83. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation. This paper was recommended by Associate Editor L. Zhang. NR 80 TC 20 Z9 20 U1 2 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1094-6977 J9 IEEE T SYST MAN CY C JI IEEE Trans. Syst. Man Cybern. Part C-Appl. Rev. PD JAN PY 2012 VL 42 IS 1 BP 123 EP 132 DI 10.1109/TSMCC.2010.2103057 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Interdisciplinary Applications SC Computer Science GA 865GW UT WOS:000298300200012 ER PT J AU Simone, CB Kramer, K O'Meara, WP Bekelman, JE Belard, A McDonough, J O'Connell, J AF Simone, Charles B., II Kramer, Kevin O'Meara, William P. Bekelman, Justin E. Belard, Arnaud McDonough, James O'Connell, John TI PREDICTED RATES OF SECONDARY MALIGNANCIES FROM PROTON VERSUS PHOTON RADIATION THERAPY FOR STAGE I SEMINOMA SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS LA English DT Article DE Seminoma; Secondary malignancies; Proton therapy; Dosimetry; Para-aortic ID TESTICULAR-CANCER; RANDOMIZED-TRIAL; 2ND CANCERS; ADJUVANT TREATMENT; TESTIS CANCER; RADIOTHERAPY; RISK; SURVEILLANCE; MORTALITY; SURVIVORS AB Purpose: Photon radiotherapy has been the standard adjuvant treatment for stage I seminoma. Single-dose carboplatin therapy and observation have emerged as alternative options due to concerns for acute toxicities and secondary malignancies from radiation. In this institutional review board-approved study, we compared photon and proton radiotherapy for stage I seminoma and the predicted rates of excess secondary malignancies for both treatment modalities. Methods and Material: Computed tomography images from 10 consecutive patients with stage I seminoma were used to quantify dosimetric differences between photon and proton therapies. Structures reported to be at increased risk for secondary malignancies and in-field critical structures were contoured. Reported models of organ-specific radiation-induced cancer incidence rates based on organ equivalent dose were used to determine the excess absolute risk of secondary malignancies. Calculated values were compared with tumor registry reports of excess secondary malignancies among testicular cancer survivors. Results: Photon and proton plans provided comparable target volume coverage. Proton plans delivered significantly lower mean doses to all examined normal tissues, except for the kidneys. The greatest absolute reduction in mean dose was observed for the stomach (119 cGy for proton plans vs. 768 cGy for photon plans; p < 0.0001). Significantly more excess secondary cancers per 10,000 patients/year were predicted for photon radiation than for proton radiation to the stomach (4.11; 95% confidence interval [CI], 3.22-5.01), large bowel (0.81; 95% CI, 0.39-1.01), and bladder (0.03; 95% CI, 0.01-0.58), while no difference was demonstrated for radiation to the pancreas (0.02; 95% CI, -0.01-0.06). Conclusions: For patients with stage I seminoma, proton radiation therapy reduced the predicted secondary cancer risk compared with photon therapy. We predict a reduction of one additional secondary cancer for every 50 patients with a life expectancy of 40 years from the time of radiation treatment with protons instead of photons. Proton radiation therapy also allowed significant sparing of most critical structures examined and warrants further study for patients with seminoma, to decrease radiation-induced toxicity. (C) 2012 Elsevier Inc. C1 [Simone, Charles B., II] NCI, NIH, Radiat Oncol Branch, Bethesda, MD 20892 USA. [Simone, Charles B., II; Bekelman, Justin E.; McDonough, James] Hosp Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA. [Kramer, Kevin; Belard, Arnaud] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. [O'Meara, William P.] Natl Naval Med Ctr, Div Radiat Oncol, Bethesda, MD USA. [O'Connell, John] Walter Reed Army Med Ctr, Radiat Oncol Serv, Washington, DC 20307 USA. RP Simone, CB (reprint author), NCI, NIH, Radiat Oncol Branch, Bldg 10 CRC,Room B2-3500,10 Ctr Dr, Bethesda, MD 20892 USA. EM csimone@alumni.upenn.edu FU U.S. Army Medical Research and Materiel Command [DAMD17-W81XWH-04-2-0022] FX This work was supported by U.S. Army Medical Research and Materiel Command under Contract Agreement No. DAMD17-W81XWH-04-2-0022. Views expressed in the manuscript are those of the authors and do not reflect official policies of the U.S. Government or Department of Army, Navy, or Defense. NR 33 TC 17 Z9 17 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0360-3016 J9 INT J RADIAT ONCOL JI Int. J. Radiat. Oncol. Biol. Phys. PD JAN PY 2012 VL 82 IS 1 BP 242 EP 249 DI 10.1016/j.ijrobp.2010.11.021 PG 8 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 868LZ UT WOS:000298526100036 PM 21236595 ER PT J AU Akkerman, I Bazilevs, Y Benson, DJ Farthing, MW Kees, CE AF Akkerman, I. Bazilevs, Y. Benson, D. J. Farthing, M. W. Kees, C. E. TI Free-Surface Flow and Fluid-Object Interaction Modeling With Emphasis on Ship Hydrodynamics SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT Symposium on Computational Methods for Fluid-Structure Interaction/ASME International Mechanical Engineering Congress and Exposition CY NOV 12-18, 2010 CL Vancouver, CANADA SP ASME ID DIRICHLET BOUNDARY-CONDITIONS; CAPTURING TECHNIQUE MITICT; GENERALIZED-ALPHA METHOD; NAVIER-STOKES EQUATIONS; FINITE-ELEMENT METHODS; SPACE-TIME PROCEDURE; WIND TURBINE ROTORS; LEVEL SET METHOD; MOVING BOUNDARIES; STABILIZATION PARAMETERS AB This paper presents our approach for the computation of free-surface/rigid-body interaction phenomena with emphasis on ship hydrodynamics. We adopt the level set approach to capture the free-surface. The rigid body is described using six-degree-of-freedom equations of motion. An interface-tracking method is used to handle the interface between the moving rigid body and the fluid domain. An Arbitrary Lagrangian-Eulerian version of the residual-based variational multiscale formulation for the Navier-Stokes and level set equations is employed in order to accommodate the fluid domain motion. The free-surface/rigid body problem is formulated and solved in a fully coupled fashion. The numerical results illustrate the accuracy and robustness of the proposed approach. [DOI: 10.1115/1.4005072] C1 [Akkerman, I.; Farthing, M. W.; Kees, C. E.] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Akkerman, I.; Bazilevs, Y.; Benson, D. J.] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92093 USA. RP Akkerman, I (reprint author), USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM iakkerman@ucsd.edu; jbazilevs@ucsd.edu RI Akkerman, Ido/H-9957-2012 NR 49 TC 27 Z9 31 U1 1 U2 8 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD JAN PY 2012 VL 79 IS 1 AR 010905 DI 10.1115/1.4005072 PG 11 WC Mechanics SC Mechanics GA 863TW UT WOS:000298192000006 ER PT J AU Tejada-Martinez, AE Akkerman, I Bazilevs, Y AF Tejada-Martinez, Andres E. Akkerman, Ido Bazilevs, Yuri TI Large-Eddy Simulation of Shallow Water Langmuir Turbulence Using Isogeometric Analysis and the Residual-Based Variational Multiscale Method SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT Symposium on Computational Methods for Fluid-Structure Interaction/ASME International Mechanical Engineering Congress and Exposition (IMECE) CY NOV 12-18, 2010 CL Vancouver, CANADA SP ASME ID COMPUTATIONAL FLUID-DYNAMICS; FINITE-ELEMENT FORMULATION; NAVIER-STOKES EQUATIONS; DIRICHLET BOUNDARY-CONDITIONS; ADVECTIVE-DIFFUSIVE SYSTEMS; GENERALIZED-ALPHA METHOD; OCEANIC MIXED-LAYER; STABILIZATION PARAMETERS; FLOWS; WAVES AB We develop a residual-based variational multiscale (RBVMS) method based on isogeometric analysis for large-eddy simulation (LES) of wind-driven shear flow with Langmuir circulation (LC). Isogeometric analysis refers to our use of NURBS (Non-Uniform Rational B-splines) basis functions which have been proven to be highly accurate in LES of turbulent flows (Bazilevs, Y., et al. 2007, Comput. Methods Appl. Mech. Eng., 197, pp. 173-201). LC consists of stream-wise vortices in the direction of the wind acting as a secondary flow structure to the primary, mean component of the flow driven by the wind. LC results from surface wave-current interaction and often occurs within the upper ocean mixed layer over deep water and in coastal shelf regions under wind speeds greater than 3m s(-1). Our LES of wind-driven shallow water flow with LC is representative of a coastal shelf flow where LC extends to the bottom and interacts with the sea bed boundary layer. The governing LES equations are the Craik-Leivobich equations (Tejada-Martinez, A. E., and Grosch, C. E., 2007, J. Fluid Mech., 576, pp. 63-108; Gargett, A. E., 2004, Science, 306, pp. 1925-1928), consisting of the time-filtered Navier-Stokes equations. These equations possess the same structure as the Navier-Stokes equations with an extra vortex force term accounting for wave-current interaction giving rise to LC. The RBVMS method with quadratic NURBS is shown to possess good convergence characteristics in wind-driven flow with LC. Furthermore, the method yields LC structures in good agreement with those computed with the spectral method in (Thorpe, S. A., 2004, Annu. Rev. Fluids Mech., 36, pp. 584 55-79) and measured during field observations in (D'Alessio, S. J., et al., 1998, J. Phys. Oceanogr., 28, pp. 1624-1641; Kantha, L., and Clayson, C. A., 2004, Ocean Modelling, 6, pp. 101-124). [DOI: 10.1115/1.4005059] C1 [Tejada-Martinez, Andres E.] Univ S Florida, Tampa, FL 33620 USA. [Akkerman, Ido] USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Akkerman, Ido; Bazilevs, Yuri] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92093 USA. RP Tejada-Martinez, AE (reprint author), Univ S Florida, Tampa, FL 33620 USA. EM aetejada@usf.edu; iakkerman@ucsd.edu; jbazilevs@ucsd.edu RI Akkerman, Ido/H-9957-2012 NR 41 TC 2 Z9 2 U1 0 U2 6 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0021-8936 EI 1528-9036 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD JAN PY 2012 VL 79 IS 1 AR 010909 DI 10.1115/1.4005059 PG 12 WC Mechanics SC Mechanics GA 863TW UT WOS:000298192000010 ER PT J AU Michael, NL AF Michael, Nelson L. TI Rare serotype adenoviral vectors for HIV vaccine development SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Editorial Material ID MALE CIRCUMCISION; DOUBLE-BLIND; INFECTION; TRIAL; PREVENTION; THAILAND; IMMUNITY AB Human adenoviral vectors are being developed for use in candidate vaccines for HIV-1 and other pathogens. However, this approach suffered a setback when an HIV-1 vaccine using an adenovirus type 5 (Ad5) vector failed to reduce, and might even have increased, the rate of HIV infection in men who were uncircumcised and who had preexisting antibodies specific for Ad5. This increased interest in the evaluation of serologically distinct adenoviral vectors. In this issue of the JCI, Frahm and coworkers report evidence that preexisting cellular immune responses directed toward Ad5 reduce the immunogenicity of antigens expressed in Ad5-vectored vaccines and have cross-reacting potential with non-Ad5 adenoviral vectors. The implications of this observation need to be carefully evaluated in future clinical trials of all serotypes of adenovirus-vectored vaccines. C1 US Mil HIV Res Program, Walter Reed Army Inst Res, Bethesda, MD 20817 USA. RP Michael, NL (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, 6720-B Rockledge Dr,Suite 400, Bethesda, MD 20817 USA. EM nmichael@hivresearch.org NR 21 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC CLINICAL INVESTIGATION INC PI ANN ARBOR PA 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USA SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD JAN PY 2012 VL 122 IS 1 BP 25 EP 27 DI 10.1172/JCI60988 PG 3 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 871WW UT WOS:000298769400008 PM 22201675 ER PT J AU Houng, HSH Garner, J Zhou, YF Lyons, A Kuschner, R Deye, G St Clair, K Douce, RW Chicaiza, W Blair, PJ Myers, CA Burke, RL Sanchez, JL Williams, M Halsey, ES AF Houng, Huo-Shu H. Garner, Jason Zhou, Yanfei Lyons, Arthur Kuschner, Robert Deye, Gregory St Clair, Kristina Douce, Richard W. Chicaiza, Wilson Blair, Patrick J. Myers, Christopher A. Burke, Ronald L. Sanchez, Jose L. Williams, Maya Halsey, Eric S. TI Emergent 2009 influenza A(H1N1) viruses containing HA D222N mutation associated with severe clinical outcomes in the Americas SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE 2009 A(HINI); Influenza; Severe infections; D222N; HA receptor binding site ID RECEPTOR-BINDING; H5N1 VIRUSES; H1N1; HEMAGGLUTININ; VIRULENCE; SUBSTITUTION; INFECTION AB Background: During the 2010-2011 influenza season, a small sub-group of 2009 influenza A(H1N1) viruses (hereafter referred to as 2009 A(H1N1)) emerged that was associated with more severe clinical outcomes in Ecuador and North America. Genetically, the haemagglutinin (HA) of this sub-clade was distinct from HAs found in viruses associated with severe outbreaks in 2010 from the United Kingdom and from other global specimens isolated earlier in the season. Objective: We report the emergence of a novel 2009 A(H1N1) variant possessing a re-emergent HA D222N mutation obtained from patients with severe respiratory illnesses and phylogenetically characterise these D222N mutants with other severe disease-causing variants clustering within a common emerging sub-clade. Case reports: In early 2011, three cases of 2009 A(H1N1) infection, two from Quito, Ecuador, and one from Washington, DC, USA, were complicated by severe pneumonia requiring mechanical ventilation, resulting in one fatality. These cases were selected due to the reported nature of the acute respiratory distress (ARD) that were captured in Department of Defence (DoD)-sponsored global influenza surveillance nets. Results: Genetically, the 2009 A(H1N1) strains isolated from two of the three severe cases carried a prominent amino acid change at position 222 (D222N) within the primary HA receptor binding site. Furthermore, these cases represent an emerging sub-clade of viruses defined by amino acid changes within HA: N31D, S162N, A186T and V272I. Phylogenetically, these viruses share a high degree of homology with strains associated with recent fatal cases in Chihuahua, Mexico. Discussion: Previously, enhanced virulence associated with the change, D222G, has been clinically linked to severe morbidity and mortality. Initial observations of the prevalence of a novel sub-clade of strains in the Americas suggest that viruses with a re-emergent D222N mutation may too correlate with severe clinical manifestations. These findings warrant heightened vigilance for emerging sub-clades of 2009 A(H1N1) and presumptive clinical implications. (C) 2011 Elsevier B. V. All rights reserved. C1 [Houng, Huo-Shu H.; Zhou, Yanfei; Lyons, Arthur; Kuschner, Robert; Deye, Gregory] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Garner, Jason] USAF, Sch Aerosp Med, Brooks City Base, TX 78235 USA. [Garner, Jason; Sanchez, Jose L.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20852 USA. [St Clair, Kristina] Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Douce, Richard W.; Chicaiza, Wilson] Hosp Vozandes Quito, Quito, Ecuador. [Blair, Patrick J.; Myers, Christopher A.] USN, Hlth Res Ctr, San Diego, CA 92106 USA. [Burke, Ronald L.; Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20904 USA. [Williams, Maya; Halsey, Eric S.] USN, Med Res Unit 6, Lima 205213230, Peru. RP Houng, HSH (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM huo-shu.houng@amedd.army.mil RI Lyons, Arthur/B-8923-2011; Valle, Ruben/A-7512-2013; OI Chicaiza-Ayala, Wilson/0000-0001-8639-698X FU United States Department of Defense [847705.82000.25GB.B0016] FX This study was funded by the United States Department of Defense Global Emerging Infections Systems Research Program, Work Unit Number: 847705.82000.25GB.B0016. NR 23 TC 15 Z9 18 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD JAN PY 2012 VL 53 IS 1 BP 12 EP 15 DI 10.1016/j.jcv.2011.09.004 PG 4 WC Virology SC Virology GA 863DF UT WOS:000298142300003 PM 22036040 ER PT J AU Dutner, J Mines, P Anderson, A AF Dutner, Joseph Mines, Pete Anderson, Alfred TI Irrigation Trends among American Association of Endodontists Members: A Web-based Survey SO JOURNAL OF ENDODONTICS LA English DT Article DE Irrigation; irrigation adjuncts; smear layer ID ROOT-CANAL IRRIGANTS; SODIUM-HYPOCHLORITE; SMEAR LAYER; BACTERIA; REMOVAL; TISSUE AB Introduction: The purpose of this study was to determine current trends in irrigation selection among endodontists. Methods: An invitation to participate in a web-based survey (Question Pro) was e-mailed to 3844 members of the American Association of Endodontists. Survey participants were asked between 10 and 14 questions based on their individual responses. Among other questions, participants were asked about their irrigant selection, irrigant concentration, smear layer removal, and use of adjuncts to irrigation. Results: A total of 3707 survey invitations were successfully delivered by e-mail after accounting for several undeliverable e-mail invitations. There were 1102 participants, with an overall completion rate of 28.5% (n = 1054). Our data indicate that >90% of respondents primarily use sodium hypochlorite, with 57% of them using it at a concentration >5.0%. Seventy-seven percent of respondents aim to remove the smear layer during endodontic treatment. At least 45% of respondents reported using an adjunct to irrigation. Conclusions: Most of the respondents are using full-strength sodium hypochlorite and are routinely removing the smear layer during endodontic treatment In addition, almost half of the respondents are using an adjunct, such as ultrasonic activation, to aid in their irrigation technique. (J Endod 2012;38:37-40) C1 [Dutner, Joseph; Mines, Pete; Anderson, Alfred] US Army Ft Bragg DENTAC, Rohde Dent Clin, Ft Bragg, NC USA. RP Dutner, J (reprint author), Bldg D3836 Ardennes Rd, Ft Bragg, NC 28310 USA. EM joseph.m.dutner@us.army.mil RI jingjing, cai/M-2687-2013 NR 26 TC 26 Z9 28 U1 2 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JAN PY 2012 VL 38 IS 1 BP 37 EP 40 DI 10.1016/j.joen.2011.08.013 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 873HL UT WOS:000298871600007 PM 22152617 ER PT J AU Thompson, JM Agee, K Sidow, SJ McNally, K Lindsey, K Borke, J Elsalanty, M Tay, FR Pashley, DH AF Thompson, Jeremy M. Agee, Kelli Sidow, Stephanie J. McNally, Kathleen Lindsey, Kimberly Borke, James Elsalanty, Mohammed Tay, Franklin R. Pashley, David H. TI Inhibition of Endogenous Dentin Matrix Metalloproteinases by Ethylenediaminetetraacetic Acid SO JOURNAL OF ENDODONTICS LA English DT Article DE Dentin; EDTA; hybrid layer; matrix metalloproteinases ID SELF-ETCHING ADHESIVES; CANAL FILLING MATERIAL; COLLAGEN DEGRADATION; PHOSPHORIC-ACID; IN-VITRO; CHLORHEXIDINE; LEAKAGE; LAYER AB Introduction: Endogenous dentin matrix metalloproteinases (MMPs) contribute to extracellular collagen matrix degradation in hybrid layers after adhesive dentin bonding procedures. Endodontic irrigants, including chlorhexidine and ethylenediaminetetraacetic acid (EDTA), might help protect the hybrid layer from this process. The objective of the present study was to determine the exposure time necessary for EDTA to inactivate endogenous MMP activity in human dentin. Methods: Dentin beams (2 x 1 x 3 mm) were prepared from midcoronal dentin of extracted third molars. The beams were demineralized in 10 wt% phosphoric acid, which also activated endogenous MMPs, and were divided into 4 experimental groups on the basis of exposure time to 17% EDTA (0, 1, 2, or 5 minutes). A generic colorimetric MMP assay measured MMP activity via absorbance at 412 nm. Data were evaluated by Kruskal-Wallis analysis of variance, followed by Dunn pair-wise comparisons at alpha = 0.05. Results: All exposure times resulted in significant inhibition (P <.001) compared with unexposed controls. Specifically, percent inhibition for 1-, 2-, and 5-minute exposure times was 55.1% +/- 21.5%, 72.8% +/- 11.7%, and 74.7% +/- 19.7%, respectively. Conclusions: Seventeen percent EDTA significantly inhibits endogenous MMP activity of human dentin within 1-2 minutes. This might minimize hybrid layer degradation after resin bonding procedures in the root canal space. (J Endod 2012;38:62-65) C1 [Agee, Kelli; Borke, James; Elsalanty, Mohammed; Pashley, David H.] Georgia Hlth Sci Univ, Coll Dent Med, Dept Oral Biol, Augusta, GA 30912 USA. [Tay, Franklin R.] Georgia Hlth Sci Univ, Coll Dent Med, Dept Endodont, Augusta, GA 30912 USA. [Thompson, Jeremy M.; Sidow, Stephanie J.; McNally, Kathleen; Lindsey, Kimberly] US Army Dent Act, Ft Gordon, GA USA. RP Pashley, DH (reprint author), Georgia Hlth Sci Univ, Coll Dent Med, Dept Oral Biol, 1120 15th St, Augusta, GA 30912 USA. EM dpashley@georgiahealth.edu FU NIDCR [R01 DE015306-06] FX Supported by NIDCR grant R01 DE015306-06 (D.H.P.). NR 31 TC 27 Z9 27 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JAN PY 2012 VL 38 IS 1 BP 62 EP 65 DI 10.1016/j.joen.2011.09.005 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 873HL UT WOS:000298871600012 PM 22152622 ER PT J AU Smith, KW Proctor, SP Ozonoff, AL McClean, MD AF Smith, Kristen W. Proctor, Susan P. Ozonoff, A. L. McClean, Michael D. TI Urinary biomarkers of occupational jet fuel exposure among air force personnel SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY LA English DT Article DE jet fuel; JP8; urinary biomarkers; 1-naphthol; 2-naphthol; naphthalene ID DERMAL EXPOSURE; WORKERS; JP-8; NAPHTHALENE; PENETRATION; 1-NAPHTHOL; COMPONENTS; ABSORPTION; INHALATION; NAPHTHOLS AB There is a potential for widespread occupational exposure to jet fuel among military and civilian personnel. Urinary metabolites of naphthalene have been suggested for use as short-term biomarkers of exposure to jet fuel (jet propulsion fuel 8 (JP8)). In this study, urinary biomarkers of JP8 were evaluated among US Air Force personnel. Personnel (n = 24) were divided a priori into high, moderate, and low exposure groups. Pre- and post-shift urine samples were collected from each worker over three workdays and analyzed for metabolites of naphthalene (1- and 2-naphthol). Questionnaires and breathingzone naphthalene samples were collected from each worker during the same workdays. Linear mixed-effects models were used to evaluate the exposure data. Post-shift levels of 1- and 2-naphthol varied significantly by a priori exposure group (levels in high group>moderate group>low group), and breathing-zone naphthalene was a significant predictor of post-shift levels of 1-and 2-naphthol, indicating that for every unit increase in breathing-zone naphthalene, there was an increase in naphthol levels. These results indicate that post-shift levels of urinary 1-and 2-naphthol reflect JP8 exposure during the work-shift and may be useful surrogates of JP8 exposure. Among the high exposed workers, significant job-related predictors of post-shift levels of 1-and 2-naphthol included entering the fuel tank, repairing leaks, direct skin contact with JP8, and not wearing gloves during the work-shift. The job-related predictors of 1-and 2-naphthol emphasize the importance of reducing inhalation and dermal exposure through the use of personal protective equipment while working in an environment with JP8. Journal of Exposure Science and Environmental Epidemiology (2012) 22, 35-45; doi: 10.1038/jes.2011.38; published online 2 November 2011 C1 [Smith, Kristen W.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Smith, Kristen W.; Proctor, Susan P.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Smith, Kristen W.; Proctor, Susan P.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA USA. [Ozonoff, A. L.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. RP Smith, KW (reprint author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1402, Boston, MA 02115 USA. EM ksmith@hsph.harvard.edu RI McClean, Michael/J-2934-2015; OI McClean, Michael/0000-0002-3902-8823; Ozonoff, Al/0000-0003-4233-5899 FU US Air Force personnel; US Army Medical Research and Materiel Command [W81XWH-06-10105]; Henry M. Jackson Foundation of the Advancement of Military Medicine FX We sincerely thank the US Air Force personnel for their cooperation and generous participation in this research project. This work was supported by the US Army Medical Research and Materiel Command award (W81XWH-06-10105) to the Henry M. Jackson Foundation of the Advancement of Military Medicine (PI: SP Proctor). The opinions or assertions contained herein are the private views of the author(s) and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. NR 28 TC 5 Z9 5 U1 0 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1559-0631 J9 J EXPO SCI ENV EPID JI J. Expo. Sci. Environ. Epidemiol. PD JAN-FEB PY 2012 VL 22 IS 1 BP 35 EP 45 DI 10.1038/jes.2011.38 PG 11 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 864NZ UT WOS:000298248200004 PM 22044926 ER PT J AU Edge, HL Brown, A Collins, J AF Edge, Harris L. Brown, Ainsmar Collins, Jason TI Pressurized Structures-Based Unmanned Aerial Vehicle Research SO JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS LA English DT Article DE Unmanned aerial vehicle (UAV); Lighter than air; Pressurized structure; Hybrid vehicle AB Several areas of unmanned aerial vehicle (UAV) performance need to be improved for the next generation of UAVs to be used successfully in expanded future combat roles. This report describes the initial research to improve the performance of UAVs through the use of lighter-than-air or pressurized structures-based (PSB) technologies. Basically, we examined how to construct the UAV in such a way that a considerable percentage of its weight will be supported by or composed of inflatable structures containing air or helium. In this way, PSB technology will reduce the amount of energy required to keep the UAV aloft, thus allowing the use of smaller, slower, and quieter motors. Using PSB technology in tandem with improving technologies in electronics, energy storage, and materials should provide a substantial increase over current UAV performance in areas needed by the military. C1 [Edge, Harris L.; Brown, Ainsmar] USA, Res Lab, Attn RDRL VTA, Aberdeen, MD 21005 USA. [Collins, Jason] Motile Robot Inc, Aberdeen Proving Ground, MD 21005 USA. RP Edge, HL (reprint author), USA, Res Lab, Attn RDRL VTA, Aberdeen, MD 21005 USA. EM harris.1.edge.civ@mail.mil NR 8 TC 1 Z9 1 U1 1 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0921-0296 J9 J INTELL ROBOT SYST JI J. Intell. Robot. Syst. PD JAN PY 2012 VL 65 IS 1-4 BP 603 EP 620 DI 10.1007/s10846-011-9566-4 PG 18 WC Computer Science, Artificial Intelligence; Robotics SC Computer Science; Robotics GA 864HO UT WOS:000298229100041 ER PT J AU Klui, A Batts, S McEntire, S Uyehara, C AF Klui, A. Batts, S. McEntire, S. Uyehara, C. TI EFFECT OF ENDOTOXIC SHOCK AND ECMO ON REGIONAL BLOOD FLOW SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Western Regional Meeting CY JAN 25-28, 2012 CL Carmel, CA C1 [Klui, A.; Batts, S.; McEntire, S.; Uyehara, C.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD JAN PY 2012 VL 60 IS 1 BP 214 EP 214 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 869XV UT WOS:000298634401314 ER PT J AU Goslings, S Kaulfers, A AF Goslings, S. Kaulfers, A. TI SULFONYLUREA INGESTION: AN UNUSUAL CAUSE OF HYPOGLYCEMIA SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Western Regional Meeting CY JAN 25-28, 2012 CL Carmel, CA C1 [Goslings, S.; Kaulfers, A.] USA, Mobile, AL USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD JAN PY 2012 VL 60 IS 1 BP 319 EP 319 PG 1 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 869XV UT WOS:000298634402028 ER PT J AU Cross, JD Stinner, DJ Burns, TC Wenke, JC Hsu, JR AF Cross, Jessica D. Stinner, Daniel J. Burns, Travis C. Wenke, Joseph C. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Return to Duty After Type III Open Tibia Fracture SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE tibia fracture; return to work; return to duty; Type III open fracture; combat injury ID OPERATION ENDURING FREEDOM; IRAQI FREEDOM; AMPUTEE SOLDIERS; INJURIES; WOUNDS AB Introduction: Despite the high incidence of battlefield orthopaedic injuries, long-term outcomes and return to duty (RTD) status have rarely been studied. Our purpose was to determine the RTD rate for soldiers who sustained Type III open tibia fractures in active combat. Methods: One hundred fifteen soldiers who sustained battle-related Type III open tibia fractures were retrospectively reviewed. The Army Physical Evaluation Board database was reviewed to determine which soldiers were able to RTD and the disability ratings of those not able to RTD. Results: The overall RTD rate was 18%, isolated open fractures had a RTD rate of 22%, salvaged extremities had a RTD rate of 20.5%, and amputees had a RTD rate of 12.5%. Older age and higher rank were both significant factors in increasing the likelihood of RTD and amputees had significantly higher disability ratings than those with salvaged extremities. Conclusion: Despite the severe nature of combat extremity wounds, 20% of patients with salvaged Type III open tibia fractures and 22% with isolated injuries were able to return to active duty. These rates are similar to those reported for civilian amputees. Amputees in our cohort were less likely to RTD. C1 [Cross, Jessica D.; Stinner, Daniel J.; Burns, Travis C.; Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Cross, Jessica D.; Stinner, Daniel J.; Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cross, JD (reprint author), Brooke Army Med Ctr DOR, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM jessica.cross@us.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 15 TC 14 Z9 14 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD JAN PY 2012 VL 26 IS 1 BP 43 EP 47 DI 10.1097/BOT.0b013e31821c0ec1 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 868UO UT WOS:000298551600010 PM 21885998 ER PT J AU Slim, J Castillo-Rojas, L Hann, M Symons, J Martinho, S Sim, J Jimenez, S Haney, B Villines, TC Shry, EA Slim, AM AF Slim, Jennifer Castillo-Rojas, Laudino Hann, Matt Symons, John Martinho, Shaun Sim, Jison Jimenez, Santiago Haney, Brian Villines, Todd C. Shry, Eric A. Slim, Ahmad M. TI Computed Tomography Coronary Angiography Versus Stress Myocardial Perfusion Imaging for Risk Stratification in Patients With High Occupational Risk SO JOURNAL OF THORACIC IMAGING LA English DT Article DE coronary computed tomography; myocardial perfusion scan; high-risk occupation; low likelihood of cardiac disease ID ASSOCIATION TASK-FORCE; ARTERY-DISEASE; AMERICAN-COLLEGE; DIAGNOSIS; GUIDELINES; COMMITTEE AB Purpose: To compare the performance of myocardial perfusion imaging (MPI) versus cardiac computed tomographic angiography (CCTA) in patients with a low pretest likelihood of obstructive coronary artery disease and high-risk occupation. Materials and Methods: We performed a retrospective chart review of all MPI and CCTA studies performed at our institution from January 2006 to May 2008. The primary outcome measure was the incidence of referral to invasive coronary angiography (ICA). Results: There were 512 MPS and 170 CCTA studies performed during the study period that met the study criteria. The average age was 35 +/- 10 for the CCTA arm and 45 +/- 5 for the myocardial perfusion scans (MPS) arm, which was statistically significant (P < 0.001), with similar sex distribution between the 2 arms (21% female patients in the MPI arm and 20% female patients in the CCTA arm). The incidence of referral to ICA was 15.8% (81/512) after MPS versus 2.4% (4/170) with CCTA (P < 0.001). Among patients referred for ICA, the false-positive rate was 93% (75/81) and 50% (2/4) with MPI and CCTA, respectively (P = 0.043). Conclusions: Compared with MPI, CCTA significantly reduced ICA referral and false-positive noninvasive imaging rates among symptomatic patients with a low probability of coronary artery disease but high occupational risk. C1 [Slim, Jennifer; Castillo-Rojas, Laudino; Hann, Matt; Symons, John; Martinho, Shaun; Sim, Jison; Jimenez, Santiago; Haney, Brian; Slim, Ahmad M.] Brooke Army Med Ctr, Serv Cardiol, San Antonio, TX USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Shry, Eric A.] Landstuhl Reg Med Ctr, Serv Cardiol, Landstuhl, Germany. RP Slim, AM (reprint author), Care Of Kai S, Brooke Army Med Ctr, Serv Cardiol, MCHE MDC, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Ahmad.slim@US.ARMY.MIL OI Villines, Todd/0000-0003-2674-3702 NR 10 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0883-5993 J9 J THORAC IMAG JI J. Thorac. Imaging PD JAN PY 2012 VL 27 IS 1 BP 40 EP 43 DI 10.1097/RTI.0b013e3181fbf983 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 869PI UT WOS:000298609800019 PM 21263354 ER PT J AU Gude, JA Mitchell, MS Russell, RE Sime, CA Bangs, EE Mech, LD Ream, RR AF Gude, Justin A. Mitchell, Michael S. Russell, Robin E. Sime, Carolyn A. Bangs, Edward E. Mech, L. David Ream, Robert R. TI Wolf population dynamics in the US Northern Rocky Mountains are affected by recruitment and human-caused mortality SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE Canis lupus; harvest; human-caused mortality; Montana; Northern Rocky Mountains; population dynamics; recruitment; wolf ID UNITED-STATES; AERIAL SURVEY; WOLVES; MANAGEMENT; CONSERVATION; DEMOGRAPHY; PAIRS; PREY AB Reliable analyses can help wildlife managers make good decisions, which are particularly critical for controversial decisions such as wolf (Canis lupus) harvest. Creel and Rotella (2010) recently predicted substantial population declines in Montana wolf populations due to harvest, in contrast to predictions made by Montana Fish, Wildlife and Parks (MFWP). We replicated their analyses considering only those years in which field monitoring was consistent, and we considered the effect of annual variation in recruitment on wolf population growth. Rather than assuming constant rates, we used model selection methods to evaluate and incorporate models of factors driving recruitment and human-caused mortality rates in wolf populations in the Northern Rocky Mountains. Using data from 27 area-years of intensive wolf monitoring, we show that variation in both recruitment and human-caused mortality affect annual wolf population growth rates and that human-caused mortality rates have increased with the sizes of wolf populations. We document that recruitment rates have decreased over time, and we speculate that rates have decreased with increasing population sizes and/or that the ability of current field resources to document recruitment rates has recently become less successful as the number of wolves in the region has increased. Estimates of positive wolf population growth in Montana from our top models are consistent with field observations and estimates previously made by MFWP for 20082010, whereas the predictions for declining wolf populations of Creel and Rotella (2010) are not. Familiarity with limitations of raw data, obtained first-hand or through consultation with scientists who collected the data, helps generate more reliable inferences and conclusions in analyses of publicly available datasets. Additionally, development of efficient monitoring methods for wolves is a pressing need, so that analyses such as ours will be possible in future years when fewer resources will be available for monitoring. (C) 2011 The Wildlife Society. C1 [Gude, Justin A.; Sime, Carolyn A.] Montana Fish Wildlife & Pk, Helena, MT 59620 USA. [Mitchell, Michael S.] Univ Montana, US Geol Survey, Montana Cooperat Wildlife Res Unit, Missoula, MT 59812 USA. [Russell, Robin E.] US Geol Survey, No Prairie Wildlife Res Ctr, Jamestown, ND 58401 USA. [Bangs, Edward E.] US Fish & Wildlife Serv, Helena, MT 59601 USA. [Mech, L. David] Univ Minnesota, US Geol Survey, No Prairie Wildlife Res Ctr, Raptor Ctr, St Paul, MN 55108 USA. [Ream, Robert R.] Montana Fish Wildlife & Pk Commiss, Helena, MT 59620 USA. [Ream, Robert R.] Univ Montana, Coll Forestry & Conservat, USA, Missoula, MT 59812 USA. [Ream, Robert R.] Univ Montana, Coll Forestry & Conservat, Wildlife Biol Program, Missoula, MT 59812 USA. RP Gude, JA (reprint author), Montana Fish Wildlife & Pk, 1420 E 6th Ave, Helena, MT 59620 USA. EM jgude@mt.gov OI Russell, Robin/0000-0001-8726-7303 FU MFWP; U.S. Fish and Wildlife Service; U.S. Geological Survey FX We dedicate this article to the hundreds of people who gave so much of their time, energy, and resources to collect the data that we used and to make the wolf recovery and conservation program in the Northern Rockies the success it has been since 1979. In particular, we acknowledge the contributions of M. Jimenez, D. Smith, J. Fontaine, T. Meier, D. Boyd, J. Holyan, C. Mack, V. Asher, L. Bradley, M. Ross, K. Laudon, J. Trapp, N. Lance, S. Nadeau, J. Rachel, I. Babcock, J. Husseman, and M. Lucid. Other employees and volunteers affiliated with the USFWS, the National Park Service, United States Forest Service, the United States Bureau of Land Management, United States Department of Agriculture Wildlife Services, academic institutions, Nez Perce Tribe, Blackfeet Nation, Confederated Salish, and Kootenai Tribe, Turner Endangered Species Fund, MFWP, Idaho Department of Fish and Game, and Wyoming Game and Fish also contributed greatly to the data set we used for our analyses. We are indebted to the citizens and private landowners of the region who reported wolves or wolf sign to agency personnel, which was often the first step in verifying a new wolf pack. We thank our pilots for their interest, dedication, and years of safe flying. Finally, we thank the past and current members of the MFWP Commission for embracing adaptive management principles embodied in Montana's wolf plan and further utilizing science and predictive models to aid in their decisions on wolf harvest. Our work on this manuscript was funded by MFWP, the U.S. Fish and Wildlife Service, and the U.S. Geological Survey. Any use of trade names is for descriptive purposes only and does not imply endorsement by the U. S. Government. K. Laudon and K. Proffitt provided valuable discussions that improved this manuscript. D. Pletscher, L. S. Mills, J. Rotella, S. Creel, 2 anonymous reviewers, and Associate Editor K. McKelvey provided constructive comments and criticism on previous drafts, and thereby improved this manuscript. Any shortcomings in this article, however, are not attributable to these individuals, and their efforts do not necessarily imply agreement with all aspects of this manuscript. NR 48 TC 17 Z9 17 U1 3 U2 59 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD JAN PY 2012 VL 76 IS 1 BP 108 EP 118 DI 10.1002/jwmg.201 PG 11 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 869GQ UT WOS:000298586200014 ER PT J AU Munir, JA Wu, HW Bauer, K Bindeman, J Byrd, C Feuerstein, IM Villines, TC Taylor, AJ AF Munir, Jamalah A. Wu, Hongyan Bauer, Kelly Bindeman, Jody Byrd, Carole Feuerstein, Irwin M. Villines, Todd C. Taylor, Allen J. TI The perimenopausal atherosclerosis transition: relationships between calcified and noncalcified coronary, aortic, and carotid atherosclerosis and risk factors and hormone levels SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY LA English DT Article DE Hormones; Women; Atherosclerosis; Imaging ID POSTMENOPAUSAL WOMEN; COMPUTED-TOMOGRAPHY; BINDING GLOBULIN; ARTERY-DISEASE; PREMENOPAUSAL; ASSOCIATION; CALCIUM AB Objective: Women of perimenopause age experience an upward transition of cardiovascular risk possibly in association with changing hormonal status. We examined the cross-sectional relationships between the atherosclerotic plaque within the coronary and carotid arteries and aorta and the menopausal hormone levels among asymptomatic perimenopausal women. Methods: The Assessment of the Transition of Hormonal Evaluation with Noninvasive Imaging of Atherosclerosis was a prospective substudy of the Prospective Army Coronary Calcium project. We screened 126 asymptomatic perimenopausal women (mean age, 50 y) using contrast-enhanced CT angiography (multidetector CT) and carotid ultrasound. Women had coronary calcium data from 5 to 10 years earlier. The measures included cardiovascular risk factors, serum hormone levels, 64-slice multidetector CT, and carotid ultrasound. Results: The prevalence of any coronary plaque was 35.5%. The prevalence of noncalcified plaque was 30.2%, and noncalcified plaque was the only manifestation of coronary artery disease in 10.7%. Markers of androgenicity (increased free testosterone and reduced sex hormoneYbinding globulin) were associated with an increased extent of calcified and noncalcified coronary artery plaque and aortic plaque. However, these relationships were not independent of cardiovascular risk factors. Follicle-stimulating hormone was directly associated with the number of aortic plaques. The levels of estrogen hormones were unrelated to plaque presence or extent. Conclusions: Coronary, aortic, and carotid arterial plaque is prevalent in perimenopausal women without cardiac symptoms. The assessment of perimenopausal hormone status was not independently associated with subclinical atherosclerosis beyond standard cardiovascular risk factors. C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Cardiol Serv, Washington, DC 20307 USA. RP Taylor, AJ (reprint author), Washington Hosp Ctr, Cardiol Sect, 110 Irving St NW,Room 1E12, Washington, DC 20010 USA. EM allen.taylor@medstar.net OI Villines, Todd/0000-0003-2674-3702 FU Congressionally Directed, Peer Reviewed Medical Research Program [ERMS 00239017-00216] FX This study was supported by the Congressionally Directed, Peer Reviewed Medical Research Program, Grant ERMS 00239017-00216. NR 14 TC 9 Z9 11 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1072-3714 J9 MENOPAUSE JI Menopause-J. N. Am. Menopause Soc. PD JAN PY 2012 VL 19 IS 1 BP 10 EP 15 DI 10.1097/gme.0b013e318221bc8d PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 870IJ UT WOS:000298662300005 PM 21900851 ER PT J AU Xiong, YH Liu, DM Li, Y Zheng, BL Haines, C Paras, J Martin, D Kapoor, D Lavernia, EJ Schoenung, JM AF Xiong, Yuhong Liu, Dongming Li, Ying Zheng, Baolong Haines, Chris Paras, Joseph Martin, Darold Kapoor, Deepak Lavernia, Enrique J. Schoenung, Julie M. TI Spark Plasma Sintering of Cryomilled Nanocrystalline Al Alloy - Part I: Microstructure Evolution SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID MG ALLOY; TEMPERATURE; CONSOLIDATION; 5083-AL-ALLOYS; DEFORMATION; DUCTILITY; GROWTH AB Aluminum alloys are widely used because they are lightweight and exhibit high strength. In recent years, spark plasma sintering (SPS) technology has emerged as a viable approach to sinter materials due to its application of rapid heating and high pressure. In this study, SPS was chosen to consolidate dense ultrafine-grained (UFG) bulk samples using cryomilled nanostructured Al 5083 alloy (Al-4.5Mg-0.57Mn-0.25Fe, wt pct) powder. Both bimodal microstructure and banded structure were observed through transmission electron microscopy (TEM) investigation. The evolution of such microstructures can be attributed to the starting powder and the process conditions, which are associated with the thermal, electrical, and pressure fields present during SPS. A finite element method (FEM) was also applied to investigate distributions in temperature, current, and stress between metallic powder particles. The FEM results reveal that the localized heating, deformation, and thermal activation occurring at interparticle regions are associated with the formation of the special microstructure. C1 [Xiong, Yuhong; Liu, Dongming; Li, Ying; Zheng, Baolong; Lavernia, Enrique J.; Schoenung, Julie M.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Liu, Dongming] Shandong Univ, Dept Mat Sci & Engn, Jinan 250061, Shandong, Peoples R China. [Haines, Chris; Paras, Joseph; Martin, Darold; Kapoor, Deepak] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Xiong, YH (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. EM jmschoenung@ucdavis.edu RI Li, Ying/G-3908-2010; Lavernia, Enrique/I-6472-2013 OI Li, Ying/0000-0003-3738-9307; Lavernia, Enrique/0000-0003-2124-8964 FU United States Army TACOM-ARDEC [W05QKN-09-C-118]; Office of Naval Research [N00014-07-1-0745]; Young Scientist Foundation of Shandong Province, China [BS2009CL043] FX This article is based upon work supported by the United States Army TACOM-ARDEC under Contract No. W05QKN-09-C-118 and the Office of Naval Research with Grant No. N00014-07-1-0745. Part of DL's work is also supported by the Young Scientist Foundation of Shandong Province, China (Grant No. BS2009CL043). NR 27 TC 15 Z9 15 U1 2 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD JAN PY 2012 VL 43A IS 1 BP 327 EP 339 DI 10.1007/s11661-011-0933-3 PG 13 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 865SF UT WOS:000298329900030 ER PT J AU Liu, DM Xiong, YH Topping, TD Zhou, YZ Haines, C Paras, J Martin, D Kapoor, D Schoenung, JM Lavernia, EJ AF Liu, Dongming Xiong, Yuhong Topping, Troy D. Zhou, Yizhang Haines, Chris Paras, Joseph Martin, Darold Kapoor, Deepak Schoenung, Julie M. Lavernia, Enrique J. TI Spark Plasma Sintering of Cryomilled Nanocrystalline Al Alloy - Part II: Influence of Processing Conditions on Densification and Properties SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID ISOSTATIC PRESSING DIAGRAMS; MECHANICAL-PROPERTIES; PRESSURE; EVOLUTION; ALUMINUM; POWDERS; GROWTH; ENERGY AB In this study, nanostructured Al 5083 powders, which were prepared via cryomilling, were consolidated using spark plasma sintering (SPS). The influence of processing conditions, e.g., the loading mode, starting microstructure (i.e., atomized vs cryomilled powders), sintering pressure, sintering temperature, and powder particle size on the consolidation response and associated mechanical properties were studied. Additionally, the mechanisms that govern densification during SPS were discussed also. The results reported herein suggest that the morphology and microstructure of the cryomilled powder resulted in an enhanced densification rate compared with that of atomized powder. The pressure-loading mode had a significant effect on the mechanical properties of the samples consolidated by SPS. The consolidated compact revealed differences in mechanical response when tested along the SPS loading axis and radial directions. Higher sintering pressures improved both the strength and ductility of the samples. The influence of grain size on diffusion was considered on the basis of available diffusion equations, and the results show that densification was attributed primarily to a plastic flow mechanism during the loading pressure period. Once the final pressure was applied, power law creep became the dominant densification mechanism. Higher sintering temperature improved the ductility of the consolidated compact at the expense of strength, whereas samples sintered at lower temperature exhibited brittle behavior. Finally, densification rate was found to be inversely proportional to the particle size. C1 [Liu, Dongming; Xiong, Yuhong; Topping, Troy D.; Zhou, Yizhang; Paras, Joseph; Lavernia, Enrique J.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Liu, Dongming] Shandong Univ, Dept Mat Sci & Engn, Jinan 250061, Peoples R China. [Haines, Chris; Paras, Joseph; Martin, Darold; Kapoor, Deepak] USA, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Liu, DM (reprint author), Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. EM jmschoenung@ucdavis.edu RI Lavernia, Enrique/I-6472-2013 OI Lavernia, Enrique/0000-0003-2124-8964 FU U.S. Army TACOM-ARDEC [W05QKN-09-C-118]; Office of Naval Research [N00014-07-1-0745]; Young Scientist Foundation of Shandong Province, China [BS2009CL043] FX This article is based on work supported by the U.S. Army TACOM-ARDEC under Contract No. W05QKN-09-C-118 and the Office of Naval Research with Grant No. N00014-07-1-0745. Part of D. Liu's work is also supported by Grant No. BS2009CL043 from the Young Scientist Foundation of Shandong Province, China. NR 32 TC 20 Z9 21 U1 3 U2 29 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD JAN PY 2012 VL 43A IS 1 BP 340 EP 350 DI 10.1007/s11661-011-0841-6 PG 11 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 865SF UT WOS:000298329900031 ER PT J AU Chu, YC Sell, TC Abt, JP Nagai, T Deluzio, J McGrail, M Rowe, R Smalley, B Lephart, SM AF Chu, Yungchien Sell, Timothy C. Abt, John P. Nagai, Takashi Deluzio, Jennifer McGrail, Mark Rowe, Rusty Smalley, Brian Lephart, Scott M. TI Air Assault Soldiers Demonstrate More Dangerous Landing Biomechanics When Visual Input Is Removed SO MILITARY MEDICINE LA English DT Article ID LOWER-EXTREMITY KINEMATICS; CRUCIATE LIGAMENT INJURY; GENDER-DIFFERENCES; MECHANISMS; REDUCTION; MOVEMENTS; KINETICS; VISION; HUMANS; RISK AB Soldiers are subjected to increased risk of musculoskeletal injuries in night operations because of limited visual input. The purpose of this study was to determine the effect of vision removal on lower extremity kinematics and vertical ground reaction forces during two-legged drop landings. The researchers tested 139 Air Assault Soldiers performing a landing task with and without vision. Removing visual input resulted in increased hip abduction at initial contact, decreased maximum knee flexion, and increased maximum vertical ground reaction force. Without vision, the timing of maximum ankle dorsi flexion for the left lea was earlier than the right leg. The observed biomechanical changes may be related to the increased risk of injury in night operations. Proper night landing techniques and supplemental training should be integrated into Soldiers' training to induce musculoskeletal and biomechanical adaptations to compensate for limited vision. C1 [Chu, Yungchien; Sell, Timothy C.; Abt, John P.; Nagai, Takashi; Deluzio, Jennifer; Lephart, Scott M.] Univ Pittsburgh, Neuromuscular Res Lab, Dept Sports Med & Nutr, Pittsburgh, PA 15203 USA. [McGrail, Mark] Blanchfield Army Community Hosp, Ft Campbell, KY 42223 USA. [Rowe, Rusty] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Smalley, Brian] Div Surg Off, Ft Campbell, KY 42223 USA. RP Chu, YC (reprint author), Univ Pittsburgh, Neuromuscular Res Lab, Dept Sports Med & Nutr, 3830 S Water St, Pittsburgh, PA 15203 USA. FU U.S. Army Medical Research and Materiel Command [W81XWH-06-2-0070, W81XWH-09-2-0095] FX This work was supported by the U.S. Army Medical Research and Materiel Command under Award No. W81XWH-06-2-0070 and W81XWH-09-2-0095. NR 30 TC 3 Z9 3 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2012 VL 177 IS 1 BP 41 EP 47 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 874RP UT WOS:000298976100011 PM 22338978 ER PT J AU Doman, DM Gerlinger, TL AF Doman, David M. Gerlinger, Tad L. TI Total Joint Arthroplasty Cost Savings With a Rapid Recovery Protocol in a Military Medical Center SO MILITARY MEDICINE LA English DT Article ID TOTAL HIP-ARTHROPLASTY; MINI-INCISION; REHABILITATION; PAIN AB The reported short-term benefits of rapid recovery protocols for total joint arthroplasty primarily come from specialized centers of excellence. The feasibility of achieving similar benefits at a military health care facility has not been reported. The authors hypothesized that application of such a protocol in this setting would decrease hospital stay and costs. A retrospective study was conducted comparing 85 hip and knee replacements by one surgeon using conventional protocol to 90 cases by a second surgeon using a rapid recovery protocol in the same hospital. Outcome measures included operative time, length of hospital stay, pain at discharge, use of inpatient rehabilitation facilities, complications requiring readmission, and inpatient admission costs. The results showed decreased length of stay by 2.9 days (p < 0.001) in the rapid recovery group, resulting in average cost savings of $1,511 (p < 0.001) with shorter operative time, equivalent pain at discharge, and fewer discharges to rehabilitation facilities. This feasibility study shows promising results, but prospective randomized trials are necessary to draw firm conclusions on the superiority of a rapid recovery protocol for total hip and knee arthroplasty in a military medical system. C1 [Doman, David M.; Gerlinger, Tad L.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA. RP Doman, DM (reprint author), Brooke Army Med Ctr, Dept Orthoped & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 16 TC 6 Z9 6 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2012 VL 177 IS 1 BP 64 EP 69 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 874RP UT WOS:000298976100016 PM 22338983 ER PT J AU McGraw, L Pickering, MA Ohlson, C Hammermeister, J AF McGraw, Leigh Pickering, Michael A. Ohlson, Carl Hammermeister, Jon TI The Influence of Mental Skills on Motivation and Psychosocial Characteristics SO MILITARY MEDICINE LA English DT Article ID INTRINSIC MOTIVATION; SELF-DETERMINATION; HEALTH PROBLEMS; COPING SKILLS; DEPRESSION; TOUGHNESS; ANXIETY; AFGHANISTAN; PERFORMANCE; STRESS AB The purpose of this observational, cross-sectional study was to assess psychosocial characteristics and intrinsic motivation in a convenience sample of Army soldiers with different mental skills profiles. Participants were recruited immediately before or immediately following regular training activities. Anonymous surveys were completed and collected in the training area. Instruments used in this study included the Ottawa Mental Skills Assessment Tool-3 Revised for Soldiers; Rosenberg Self-esteem Scale; Depression Anxiety Stress Scale-21; University of California, Los Angeles, Loneliness Scale; Beck Hopelessness Scale; Intrinsic Motivation Inventory; and an anger measure. Soldiers with strong mental skill profiles were more intrinsically motivated and psychosocially healthier than their peers with weaker mental skill profiles. It is recommended that a proactive approach to psychological health promotion practices in soldiers be sought rather than reactive treatment plans to psychological sequelae. Future research must examine the role of psychosocial fitness and adaptability to enhance mental skills fitness. C1 [McGraw, Leigh] Madigan Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, Ft Lewis, WA 98431 USA. [Pickering, Michael A.; Ohlson, Carl; Hammermeister, Jon] US Mil Acad, Army Ctr Enhanced Performance, West Point, NY 10996 USA. RP McGraw, L (reprint author), Madigan Army Med Ctr, Ctr Nursing Sci & Clin Inquiry, 9040A Reid St, Ft Lewis, WA 98431 USA. NR 60 TC 0 Z9 0 U1 1 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2012 VL 177 IS 1 BP 77 EP 84 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 874RP UT WOS:000298976100018 PM 22338985 ER PT J AU Park, SJ Kenny, PR Palekar, NA AF Park, Stephen J. Kenny, Patrick R. Palekar, Nicole A. TI Labor-Associated Eosinophilic Gastroenteritis SO MILITARY MEDICINE LA English DT Article AB A 30-year-old woman who was 2 weeks postpartum presented with intermittent dysphagia since delivery. Esophagogastroduodenoscopy (EGD) revealed linear furrowing, trachealization, and a B-type distal esophageal ring with normal appearing stomach and duodenum. Biopsies showed eosinophilic esophagitis. Over 3 weeks, she developed severe midepigastric pain. Laboratory studies revealed an elevated absolute eosinophil count of 990/dL (normal 0-450/dL), and a computed tomography scan showed proximal jejunal thickening. Repeat esophagogastroduodenoscopy showed gastric erythema and edema of the duodenal mucosa. Biopsies revealed greater than 50 eosinophils per high power field in the intraepithelial mucosa with extension into the muscularis and serosa, consistent with eosinophilic gastroenteritis (EG). EG represents an uncommon inflammatory disease marked by gastrointestinal symptoms, eosinophilic infiltration in one or more areas of the gastrointestinal tract, and absence of parasitic or extraintestinal disease. Approximately 300 cases have been reported since 1937. This case contains two unique aspects. First, the clinical and endoscopic progression of gastrointestinal cosinophilic disease from the esophagus to the stomach and small bowel was chronologically documented. This proximal to distal luminal progression has not been previously reported. The possible link to her pregnancy is also notable as only two previous cases of labor-associated EG have been published. C1 [Park, Stephen J.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Kenny, Patrick R.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Palekar, Nicole A.] Cleveland Clin Florida, Dept Gastroenterol & Hepatol, Weston, FL 33331 USA. RP Park, SJ (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 5 TC 2 Z9 2 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2012 VL 177 IS 1 BP 99 EP 100 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 874RP UT WOS:000298976100022 PM 22338989 ER PT J AU Hawley, JS Bebarta, VS Steele, JT AF Hawley, Jason S. Bebarta, Vikhyat S. Steele, John T. TI Intra-Arterial tPA Treatment for Basilar Artery Thrombosis in the Combat Zone: An Example of Modern Nontrauma Medical Care in War SO MILITARY MEDICINE LA English DT Article AB Military physicians deploy primarily to care for traumatic injuries. However, critically ill medical patients are also evaluated and treated in theater with similar capability as hospitals in the United States because of the close proximity of medical and surgical specialists and advanced equipment in combat support and theater hospitals. We report a case of a 33-year-old soldier diagnosed with a basilar infarct. treated with fibrinolytics, and reversal of severe neurological deficits while treated in the U.S. operational Afghanistan Theater. C1 [Hawley, Jason S.] Walter Reed Med Ctr, Bethesda, MD USA. [Bebarta, Vikhyat S.; Steele, John T.] Wilford Hall USAF Med Ctr, Lackland AFB, TX USA. [Bebarta, Vikhyat S.; Steele, John T.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Bebarta, Vikhyat S.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Hawley, JS (reprint author), Walter Reed Med Ctr, Bethesda, MD USA. RI Bebarta, Vikhyat/M-1513-2015 NR 2 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 2012 VL 177 IS 1 BP 121 EP 122 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 874RP UT WOS:000298976100027 PM 22338994 ER PT J AU Cho, J Lin, QB Yang, S Simmons, JG Cheng, YW Lin, E Yang, JQ Foreman, JV Everitt, HO Yang, WT Kim, J Liu, J AF Cho, Jinhyun Lin, Qiubao Yang, Sungwoo Simmons, Jay G., Jr. Cheng, Yingwen Lin, Erica Yang, Jianqiu Foreman, John V. Everitt, Henry O. Yang, Weitao Kim, Jungsang Liu, Jie TI Sulfur-doped zinc oxide (ZnO) Nanostars: Synthesis and simulation of growth mechanism SO NANO RESEARCH LA English DT Article DE ZnO nanostar; hexagram; thiourea; sulfur doping; growth mechanism; ab initio simulation ID NANOWIRE ARRAYS; OPTICAL-PROPERTIES; NANOBELTS; LUMINESCENCE; METALS AB We present a bottom-up synthesis, spectroscopic characterization, and ab initio simulations of star-shaped hexagonal zinc oxide (ZnO) nanowires. The ZnO nanostructures were synthesized by a low-temperature hydrothermal growth method. The cross-section of the ZnO nanowires transformed from a hexagon to a hexagram when sulfur dopants from thiourea [SC(NH(2))(2)] were added into the growth solution, but no transformation occurred when urea (OC(NH(2))(2)) was added. Comparison of the X-ray photoemission and photoluminescence spectra of undoped and sulfur-doped ZnO confirmed that sulfur is responsible for the novel morphology. Large-scale theoretical calculations were conducted to understand the role of sulfur doping in the growth process. The ab initio simulations demonstrated that the addition of sulfur causes a local change in charge distribution that is stronger at the vertices than at the edges, leading to the observed transformation from hexagon to hexagram nanostructures. C1 [Lin, Qiubao; Yang, Sungwoo; Simmons, Jay G., Jr.; Cheng, Yingwen; Lin, Erica; Yang, Jianqiu; Yang, Weitao; Liu, Jie] Duke Univ, Dept Chem, French Family Sci Ctr, Durham, NC 27708 USA. [Cho, Jinhyun; Kim, Jungsang] Duke Univ, Dept Elect & Comp Engn, Fitzpatrick Inst Photon, Durham, NC 27708 USA. [Lin, Qiubao] Jimei Univ, Sch Sci, Xiamen 361021, Peoples R China. [Foreman, John V.; Everitt, Henry O.] USA, Aviat & Missile Res Dev & Engn Ctr, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA. [Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Liu, J (reprint author), Duke Univ, Dept Chem, French Family Sci Ctr, Durham, NC 27708 USA. EM j.liu@duke.edu RI Simmons, Jay/G-4513-2011; Cheng, Yingwen/B-2202-2012; Yang, Weitao/C-1109-2008; Everitt, Henry/L-7118-2013; Liu, Jie/B-4440-2010; Yang, Sungwoo/G-4484-2011 OI Cheng, Yingwen/0000-0002-0778-5504; Everitt, Henry/0000-0002-8141-3768; Liu, Jie/0000-0003-0451-6111; Yang, Sungwoo/0000-0002-6557-4940 FU Duke University; National Science Foundation (NSF) [ECCS-0925587, CHE-09-11119]; Science Foundation of Jimei University, China [ZQ2010006] FX This work was supported by grants from Duke University, National Science Foundation (NSF) (Nos. ECCS-0925587 and CHE-09-11119), and the Science Foundation of Jimei University, China (No. ZQ2010006). The authors thank Professor Jeffrey Glass of Duke University for helpful discussions. The project also benefitted from access to the Duke Shared Materials Instrument Facility. NR 28 TC 16 Z9 17 U1 6 U2 47 PU TSINGHUA UNIV PRESS PI BEIJING PA TSINGHUA UNIV, RM A703, XUEYAN BLDG, BEIJING, 10084, PEOPLES R CHINA SN 1998-0124 J9 NANO RES JI Nano Res. PD JAN PY 2012 VL 5 IS 1 BP 20 EP 26 DI 10.1007/s12274-011-0180-3 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 876CQ UT WOS:000299085200003 ER PT J AU Merkle, LD Sutorik, AC Sanamyan, T Hussey, LK Gilde, G Cooper, C Dubinskii, M AF Merkle, Larry D. Sutorik, Anthony C. Sanamyan, Tigran Hussey, Lindsay K. Gilde, Gary Cooper, Christopher Dubinskii, Mark TI Fluorescence of Er3+:AlN polycrystalline ceramic SO OPTICAL MATERIALS EXPRESS LA English DT Article ID SITE-SELECTIVE SPECTROSCOPY; TRANSPARENT AIN CERAMICS; RARE-EARTH IONS; ALUMINUM NITRIDE; ALN CERAMICS; GAN; LUMINESCENCE; ERBIUM; CATHODOLUMINESCENCE; YAG AB We report what we believe to be the first preparation and optical spectroscopy of Er3+ doped into bulk AlN ceramic. The material was prepared via hot press sintering of AlN with Er2O3 and [NH4][ErF4], which yielded fully dense, translucent, hexagonal AlN. The Er3+ concentration is a small fraction of a percent, and resides in multiple sites, with one type of center dominant. A number of the energy levels of Er3+ are identified for this center. The temperature dependent fluorescence lifetime is probably radiative, and on that basis the stimulated emission and absorption cross section spectra are inferred for the I-4(13/2) <-> I-4(15/2) transitions. (C) 2011 Optical Society of America C1 [Merkle, Larry D.; Sanamyan, Tigran; Hussey, Lindsay K.; Dubinskii, Mark] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Sutorik, Anthony C.; Gilde, Gary; Cooper, Christopher] USA, Res Lab, RDRL WMM E, Aberdeen Proving Ground, MD 21005 USA. [Hussey, Lindsay K.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. RP Merkle, LD (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM larry.d.merkle.civ@mail.mil FU High Energy Lasers Joint Technology Office FX The authors wish to thank the High Energy Lasers Joint Technology Office for their financial support of this work, and Zackery Fleischman for assistance with some of the spectroscopy. NR 42 TC 6 Z9 6 U1 1 U2 20 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 2159-3930 J9 OPT MATER EXPRESS JI Opt. Mater. Express PD JAN 1 PY 2012 VL 2 IS 1 BP 78 EP 91 PG 14 WC Materials Science, Multidisciplinary; Optics SC Materials Science; Optics GA 875RA UT WOS:000299050700011 ER PT J AU Rushton, DL Tripathi, P Rabara, RC Lin, J Ringler, P Boken, AK Langum, TJ Smidt, L Boomsma, DD Emme, NJ Chen, X Finer, JJ Shen, QXJ Rushton, PJ AF Rushton, Deena L. Tripathi, Prateek Rabara, Roel C. Lin, Jun Ringler, Patricia Boken, Ashley K. Langum, Tanner J. Smidt, Lucas Boomsma, Darius D. Emme, Nicholas J. Chen, Xianfeng Finer, John J. Shen, Qingxi J. Rushton, Paul J. TI WRKY transcription factors: key components in abscisic acid signalling SO PLANT BIOTECHNOLOGY JOURNAL LA English DT Review DE abscisic acid; WRKY transcription factor; seed germination; drought; abiotic stress ID CHELATASE H-SUBUNIT; BARLEY ALEURONE CELLS; DNA-BINDING PROTEINS; ABIOTIC STRESS; DISEASE-RESISTANCE; DROUGHT TOLERANCE; RESPONSIVE GENES; SEED DEVELOPMENT; PLANT-RESPONSES; ZINC-FINGER AB WRKY transcription factors (TFs) are key regulators of many plant processes, including the responses to biotic and abiotic stresses, senescence, seed dormancy and seed germination. For over 15 years, limited evidence has been available suggesting that WRKY TFs may play roles in regulating plant responses to the phytohormone abscisic acid (ABA), notably some WRKY TFs are ABA-inducible repressors of seed germination. However, the roles of WRKY TFs in other aspects of ABA signalling, and the mechanisms involved, have remained unclear. Recent significant progress in ABA research has now placed specific WRKY TFs firmly in ABA-responsive signalling pathways, where they act at multiple levels. In Arabidopsis, WRKY TFs appear to act downstream of at least two ABA receptors: the cytoplasmic PYR/PYL/RCAR-protein phosphatase 2C-ABA complex and the chloroplast envelopelocated ABARABA complex. In vivo and in vitro promoter-binding studies show that the target genes for WRKY TFs that are involved in ABA signalling include well-known ABA-responsive genes such as ABF2, ABF4, ABI4, ABI5, MYB2, DREB1a, DREB2a and RAB18. Additional well-characterized stress-inducible genes such as RD29A and COR47 are also found in signalling pathways downstream of WRKY TFs. These new insights also reveal that some WRKY TFs are positive regulators of ABA-mediated stomatal closure and hence drought responses. Conversely, many WRKY TFs are negative regulators of seed germination, and controlling seed germination appears a common function of a subset of WRKY TFs in flowering plants. Taken together, these new data demonstrate that WRKY TFs are key nodes in ABA-responsive signalling networks. C1 [Rushton, Deena L.; Tripathi, Prateek; Rabara, Roel C.; Lin, Jun; Boken, Ashley K.; Langum, Tanner J.; Smidt, Lucas; Boomsma, Darius D.; Emme, Nicholas J.; Rushton, Paul J.] S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA. [Ringler, Patricia; Shen, Qingxi J.] Univ Nevada, Dept Biol Sci, Las Vegas, NV 89154 USA. [Chen, Xianfeng] US Army Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Finer, John J.] Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Hort & Crop Sci, Wooster, OH 44691 USA. RP Rushton, PJ (reprint author), S Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA. EM paul.rushton@sdstate.edu RI Finer, John/N-4713-2014; Tripathi, Prateek/L-2478-2016; TRIPATHI, PRATEEK/C-3883-2009; OI Finer, John/0000-0001-8004-5468; Tripathi, Prateek/0000-0002-0958-2428; TRIPATHI, PRATEEK/0000-0002-0958-2428; Rabara, Roel/0000-0001-8608-7060 FU National Research Initiative from the USDA National Institute of Food and Agriculture [2008-35100-04519, 2008-35100-05969, 2007-35304-18297]; United Soybean Board; Consortium for Plant Biotechnology Research; South Dakota Soybean Research and Promotion Council; North Central Soybean Research Program; US Army Environmental Quality at ERDC FX We thank Senthil Subramanian for helpful comments on the manuscript. This project was supported by National Research Initiative grants 2008-35100-04519 and 2008-35100-05969 from the USDA National Institute of Food and Agriculture to PJR and QJS and grant 2007-35304-18297 to QJS. Research in the Rushton laboratory is also supported by The United Soybean Board, The Consortium for Plant Biotechnology Research, The South Dakota Soybean Research and Promotion Council and The North Central Soybean Research Program. Funding for X. Chen was provided by the US Army Environmental Quality research program at ERDC. The authors appreciate kind discussions with, and suggestions from, Dr. Edward J. Perkins, Dr. Kurt A. Gust and Dr. Victor F. Medina of the Environmental Laboratory, the U.S. Army Engineer Research and Development Center. NR 75 TC 120 Z9 141 U1 17 U2 187 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1467-7644 J9 PLANT BIOTECHNOL J JI Plant Biotechnol. J. PD JAN PY 2012 VL 10 IS 1 BP 2 EP 11 DI 10.1111/j.1467-7652.2011.00634.x PG 10 WC Biotechnology & Applied Microbiology; Plant Sciences SC Biotechnology & Applied Microbiology; Plant Sciences GA 862ME UT WOS:000298094800002 PM 21696534 ER PT J AU Chan, RK Bojovic, B Talbot, SG Weiss, D Pribaz, JJ AF Chan, Rodney K. Bojovic, Branko Talbot, Simon G. Weiss, Denton Pribaz, Julian J. TI Lower Lip Suspension Using Bilateral Temporalis Muscle Flaps and Fascia Lata Grafts SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID REANIMATION AB Oral incompetence following composite reconstruction of total and subtotal lower lip defects without any functioning lower lip muscle is a difficult problem for reconstructive surgeons. The authors retrospectively reviewed the use of a novel bilateral temporalis suspension technique for oral incompetence following lower lip reconstruction over a 10-year period. The timing of the reconstruction, cause of the defect, period of follow-up, and any complications were noted. Three cases of lower lip resuspension using bilateral temporalis flaps and fascia lata grafts were performed from 2000 to 2010. Two cases were secondary to burn trauma and one was from ballistic trauma. All patients underwent traditional means of reconstruction using free microvascular composite tissue transfer with and without fascial slings. All three patients presented with persistent lower lip incompetence. The average interval between the initial reconstructive operations and the resuspension operations was 1.6 years. All patients achieved dynamic oral competence at the first postoperative visit. At a mean follow-up of 3.6 years, all patients had maintained lower lip function. Dynamic lower lip resuspension with bilateral temporalis flaps and fascia lata grafts is an option for refractory lower lip drooping following total and subtotal loss, especially after conventional static reconstruction and without any functional orbicularis muscle. (Plast. Reconstr. Surg. 129: 119, 2012.) C1 [Pribaz, Julian J.] Brigham & Womens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA. Brooke Army Med Ctr, Clin Div, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Pribaz, JJ (reprint author), Brigham & Womens Hosp, Dept Surg, Div Plast Surg, 75 Francis St, Boston, MA 02115 USA. OI Chan, Rodney/0000-0002-5061-847X NR 8 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD JAN PY 2012 VL 129 IS 1 BP 119 EP 122 DI 10.1097/PRS.0b013e31823620b0 PG 4 WC Surgery SC Surgery GA 873BZ UT WOS:000298857100081 PM 22186504 ER PT J AU Fink, J Ribeiro, A Kumar, V AF Fink, Jonathan Ribeiro, Alejandro Kumar, Vijay TI Robust Control for Mobility and Wireless Communication in Cyber-Physical Systems With Application to Robot Teams SO PROCEEDINGS OF THE IEEE LA English DT Article DE Mobile ad hoc networks; motion planning; multirobot systems ID NETWORKS AB In this paper, a system architecture to provide end-to-end network connectivity for autonomous teams of robots is discussed. The core of the proposed system is a cyber-physical controller whose goal is to ensure network connectivity as robots move to accomplish their assigned tasks. Due to channel quality uncertainties inherent to wireless propagation, we adopt a stochastic model where achievable rates are modeled as random variables. The cyber component of the controller determines routing variables that maximize the probability of having a connected network for given positions. The physical component determines feasible robot trajectories that are restricted to safe configurations which ensure these probabilities stay above a minimum reliability level. Local trajectory planning algorithms are proposed for simple environments and leveraged to obtain global planning algorithms to handle complex surroundings. The resulting integrated controllers are robust in that end-to-end communication survives with high probability even if individual point-to-point links are likely to fail with significant probability. Experiments demonstrate that the global planning algorithm succeeds in navigating a complex environment while ensuring that end-to-end communication rates meet or exceed prescribed values within a target failure tolerance. C1 [Fink, Jonathan; Kumar, Vijay] Univ Penn, Grasp Lab, Philadelphia, PA 19104 USA. [Ribeiro, Alejandro] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA. RP Fink, J (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM jonfink@grasp.upenn.edu; aribeiro@seas.upenn.edu; kumar@grasp.upenn.edu FU U.S. Army Research Laboratory [W911NF-08-2-0004]; U.S. Office of Naval Research (ONR) [N00014-08-1-0696, N00014-07-1-0829] FX This work was supported by the U.S. Army Research Laboratory under Grant W911NF-08-2-0004, and the U.S. Office of Naval Research (ONR) under Grants N00014-08-1-0696 and N00014-07-1-0829. NR 30 TC 24 Z9 25 U1 2 U2 22 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9219 EI 1558-2256 J9 P IEEE JI Proc. IEEE PD JAN PY 2012 VL 100 IS 1 SI SI BP 164 EP 178 DI 10.1109/JPROC.2011.2161427 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 865QW UT WOS:000298326400013 ER PT J AU Mann, EA Baun, MM Meininger, JC Wade, CE AF Mann, Elizabeth A. Baun, Mara M. Meininger, Janet C. Wade, Charles E. TI COMPARISON OF MORTALITY ASSOCIATED WITH SEPSIS IN THE BURN, TRAUMA, AND GENERAL INTENSIVE CARE UNIT PATIENT: A SYSTEMATIC REVIEW OF THE LITERATURE SO SHOCK LA English DT Article; Proceedings Paper CT 34th Annual Conference on Shock CY JUN 11-14, 2011 CL Shock Soc, Norfolk, VA HO Shock Soc DE Outcome; prevalence; comparative analysis ID DECISION-SUPPORT-SYSTEMS; SEPTIC SHOCK; ORGAN DYSFUNCTION; SURVIVING SEPSIS; RISK-FACTORS; EPIDEMIOLOGY; DEATH; INFECTION; OUTCOMES; INJURY AB The purpose of this systematic review of the literature was to determine the association of sepsis with mortality in the severely injured adult patient by means of a comparative analysis of sepsis in burn and trauma injury with other critically ill populations. The MEDLINE (PubMed), Cochrane Library, and ProQuest databases were searched. The following keywords and MeSH headings were used: "sepsis,'' septicemia,'' "septic shock,'' "epidemiology,'' "burns,'' "thermal injury,'' "trauma,'' "wounds and injuries,'' "critical care,'' "intensive care,'' "outcomes,'' and "mortality.'' Included studies were clinical studies of adult burn, trauma, and critically ill patients that reported survival data for sepsis. Thirty-eight articles were reviewed (9 burn, 11 trauma, 18 general critical care). The age of burn (G45 years) and trauma (34-49 years) groups was lower than the general critical care (57-64 years) population. Sepsis prevalence varied with trauma-injured patients experiencing fewer episodes (2.4%-16.9%) contrasted with burn patients (8%-42.5%) and critical care patients (19%-38%). Survival differed with trauma patients experiencing a lower rate of mortality associated with sepsis (7%-36.9%) compared with the burn (28%-65%) and critical care (21%-53%) groups. This study is the first to compare sepsis outcomes in three distinct patient populations: burn, trauma, and general critical care. Trauma patients tend to have relatively low sepsis-associated mortality; burn patients and the older critical care population have higher prevalence of sepsis with worse outcomes. Great variability of criteria to identify septic patients among studies compromises population comparisons. C1 [Mann, Elizabeth A.] USA, Inst Surg Res, San Antonio, TX USA. [Mann, Elizabeth A.; Baun, Mara M.; Meininger, Janet C.; Wade, Charles E.] Univ Texas Hlth Sci Ctr, Houston, TX USA. RP Mann, EA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Houston, TX 78234 USA. EM Elizabeth.Mann@us.army.mil NR 78 TC 38 Z9 42 U1 1 U2 12 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JAN PY 2012 VL 37 IS 1 BP 4 EP 16 DI 10.1097/SHK.0b013e318237d6bf PG 13 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 873LN UT WOS:000298884900002 PM 21941222 ER PT J AU Isbell, CL Batchinsky, AI Hetz, KM Baker, WL Cancio, LC AF Isbell, Claire Larson Batchinsky, Andriy I. Hetz, Katherine M. Baker, William L. Cancio, Leopoldo C. TI CORRELATION BETWEEN CAPNOGRAPHY AND ARTERIAL CARBON DIOXIDE BEFORE, DURING, AND AFTER SEVERE CHEST INJURY IN SWINE SO SHOCK LA English DT Article DE End-tidal carbon dioxide; pulmonary contusion; pulmonary dead space; swine; blood gas analysis; carbon dioxide ID TRAUMATIC BRAIN-INJURY; EXPERIMENTAL PULMONARY CONTUSION; RAPID-SEQUENCE INTUBATION; DEAD SPACE; PREHOSPITAL VENTILATION; GRADIENT; HYPERVENTILATION; MANAGEMENT; MORTALITY; HYPOXIA AB The relationship between end-tidal carbon dioxide (EtCO(2)) and arterial carbon dioxide (PaCO(2))-if better defined-could facilitate the difficult task of ventilation in prehospital trauma patients. We aimed to study the PaCO(2)-EtCO(2) relationship before, during, and after chest trauma, hemorrhage, and resuscitation in swine. Twenty-four swine were intubated, anesthetized, and monitored in an animal intensive care unit during three phases: phase 1 (day 1, healthy animals); phase 2 (day 2, injury), which consisted of blunt chest trauma, hemorrhage, and resuscitation; and phase 3 (day 2, after injury). "Respiratory maneuvers'' (changes in respiratory rate and tidal volume [TV], intended to vary the PaCO(2) over a range of 25 to 85 mmHg, were performed during phases 1 and 3. End-tidal CO(2) and PaCO(2) were recorded after each respiratory maneuver and analyzed using linear regression. During phase 1, PaCO(2) and EtCO(2) were strongly correlated (r(2) = 0.97, P < 0.01). During phase 2, animals developed decreased oxygenation (Pao(2):Fio(2) [fraction of inspired oxygen] ratio <200) and hypotension (mean arterial pressure, 20-50 mmHg); the PaCO(2)-EtCO(2) relationship deteriorated (r(2) = 0.25, P < 0.0001). During phase 3, oxygenation, hemodynamics, and the PaCO(2)-EtCO(2) relationship recovered (r(2) = 0.92, P < 0.01). End-tidal CO(2) closely correlates to PaCO(2) in healthy animals and after injury/resuscitation across a wide range of respiratory rates and tidal volumes. Once oxygenation and hemodynamics are restored, EtCO(2) can be used to predict PaCO(2) following chest trauma/hemorrhage and should be considered for patient monitoring. This work demonstrated that EtCO(2) alone can reliably be used to estimate PaCO(2) in uninjured subjects and in those subjects who have been resuscitated from severe injury. Immediately after blunt chest injury, the correlation between EtCO(2) and PaCO(2) is temporarily unstable. Under these circumstances (with abnormal oxygenation and/or hemodynamics), greater caution and other monitoring tools may be required. C1 [Isbell, Claire Larson; Batchinsky, Andriy I.; Hetz, Katherine M.; Baker, William L.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM Lee.cancio@us.army.mil FU Combat Casualty Care Research Program (Combat Critical Care Engineering Task Area); US Army Institute of Surgical Research; US Army Medical Research and Materiel Command, Ft Detrick, Maryland FX This study was funded by the Combat Casualty Care Research Program (Combat Critical Care Engineering Task Area), US Army Institute of Surgical Research, and US Army Medical Research and Materiel Command, Ft Detrick, Maryland. NR 30 TC 7 Z9 7 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JAN PY 2012 VL 37 IS 1 BP 103 EP 109 DI 10.1097/SHK.0b013e3182391862 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 873LN UT WOS:000298884900015 PM 21993447 ER PT J AU Kashani, M Eliasson, A Vernalis, M AF Kashani, Mariam Eliasson, Arn Vernalis, Marina TI Perceived stress correlates with disturbed sleep: A link connecting stress and cardiovascular disease SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS LA English DT Article DE Cardiovascular disease; perceived stress; risk factors; sleep; sleep quality; stress ID PSYCHOLOGICAL DISTRESS; RISK-FACTORS; JOB STRAIN; ASSOCIATION; STROKE; HEALTH; QUESTIONNAIRE; BEHAVIORS; MEN AB The association between stress and cardiovascular disease (CVD) risk is becoming established. A mechanistic link clarifying the intermediate steps between the experience of stress and the development of CVD would support this association. We sought to examine the role of perceived stress as a factor associated with disturbed sleep with the goal of providing an explanation for the stress-CVD connection. We performed a cross-sectional analysis of data recorded by subjects at entry to our CVD prevention program. Data collection included questionnaire surveys, anthropometrics, and a CVD-relevant laboratory panel. Of 350 consecutively enrolled subjects (mean age 54.4 +/- 12.4 [SD] years, 138 men, 39%), 165 (47%) scored above the mean for stress measures. These high-stress subjects displayed an increased cardiovascular risk profile including elevated body mass index (mean +/- SD 31.1 +/- 5.9 vs. 29.0 +/- 5.9, r(s) = 0.175), increased waist circumference (102 +/- 17 cm vs. 98 +/- 14, r(s) = 0.135), and elevated high-sensitivity serum C-reactive protein (0.384 mg/dl vs. 0.356, r(s) = 0.109). High-stress subjects also demonstrated greater daytime sleepiness (Epworth Sleepiness Scale: 10.4 +/- 5.0 vs. 7.8 +/- 4.8, r(s) < 0.316), greater fatigue (fatigue scale: 5.4 +/- 2.2 vs. 3.4 +/- 2.4, r(s) = 0.484), poorer sleep quality (Pittsburgh Sleep Quality Index: 8.5 +/- 4.4 vs. 5.9 +/- 4.0, r(s) = 0.416), and shorter sleep duration (20 min less/24 h, r(s) = negative 0.177) with a higher risk for sleep apnea (60% at high risk vs. 40%, p = 0.003) than low-stress subjects. High stress was associated with significant disturbances in sleep duration and sleep quality. Stress levels also correlated with daytime consequences of disturbed sleep. The stress-sleep connection may be an important mechanistic mediator of the association between stress and CVD. C1 [Kashani, Mariam; Eliasson, Arn; Vernalis, Marina] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20012 USA. RP Eliasson, A (reprint author), Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, POB 59608, Washington, DC 20012 USA. EM aheliasson@aol.com FU Henry M. Jackson Foundation for the Advancement of Military Medicine FX This study was supported by the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 38 TC 19 Z9 20 U1 0 U2 19 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1025-3890 J9 STRESS JI Stress PD JAN PY 2012 VL 15 IS 1 BP 45 EP 51 DI 10.3109/10253890.2011.578266 PG 7 WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences & Neurology GA 861UE UT WOS:000298043900005 PM 21682656 ER PT J AU Stormer, M Arroyo, A Brachert, J Carrero, H Devine, D Epstein, JS Gabriel, C Gelber, C Goodrich, R Hanschmann, KM Heath, DG Jacobs, MR Keil, S de Korte, D Lambrecht, B Lee, CK Marcelis, J Marschner, S McDonald, C McGuane, S McKee, M Muller, TH Muthivhi, T Pettersson, A Radziwon, P Ramirez-Arcos, S Reesink, HW Rojo, J Rood, I Schmidt, M Schneider, CK Seifried, E Sicker, U Wendel, S Wood, EM Yomtovian, RA Montag, T AF Stoermer, M. Arroyo, A. Brachert, J. Carrero, H. Devine, D. Epstein, J. S. Gabriel, C. Gelber, C. Goodrich, R. Hanschmann, K. -M. Heath, D. G. Jacobs, M. R. Keil, S. de Korte, D. Lambrecht, B. Lee, C. -K. Marcelis, J. Marschner, S. McDonald, C. McGuane, S. McKee, M. Mueller, T. H. Muthivhi, T. Pettersson, A. Radziwon, P. Ramirez-Arcos, S. Reesink, H. W. Rojo, J. Rood, I. Schmidt, M. Schneider, C. K. Seifried, E. Sicker, U. Wendel, S. Wood, E. M. Yomtovian, R. A. Montag, T. TI Establishment of the first International Repository for Transfusion-Relevant Bacteria Reference Strains: ISBT Working Party Transfusion-Transmitted Infectious Diseases (WP-TTID), Subgroup on Bacteria SO VOX SANGUINIS LA English DT Article DE bacteria reference strains; bacterial contamination; international reference material; pathogen reduction; platelet screening; repository; validation ID BLOOD COMPONENTS; PHOTOCHEMICAL TREATMENT; ULTRAVIOLET-LIGHT; PATHOGEN INACTIVATION; CONTAMINATION; REDUCTION; CULTURE; DIVERSION; PLATELETS; PLASMA AB Background Bacterial contamination of platelet concentrates (PCs) still remains a significant problem in transfusion with potential important clinical consequences, including death. The International Society of Blood Transfusion Working Party on Transfusion-Transmitted Infectious Diseases, Subgroup on Bacteria, organised an international study on Transfusion-Relevant Bacteria References to be used as a tool for development, validation and comparison of both bacterial screening and pathogen reduction methods. Material and Methods Four Bacteria References (Staphylococcus epidermidis PEI-B-06, Streptococcus pyogenes PEI-B-20, Klebsiella pneumoniae PEI-B-08 and Escherichia coli PEI-B-19) were selected regarding their ability to proliferate to high counts in PCs and distributed anonymised to 14 laboratories in 10 countries for identification, enumeration and bacterial proliferation in PCs after low spiking (0 3 and 0 03 CFU/ml), to simulate contamination occurring during blood donation. Results Bacteria References were correctly identified in 98% of all 52 identifications. S. pyogenes and E. coli grew in PCs in 11 out of 12 laboratories, and K. pneumoniae and S. epidermidis replicated in all participating laboratories. The results of bacterial counts were very consistent between laboratories: the 95% confidence intervals were for S. epidermidis: 1.19-1.32 x 10(7) CFU/ml, S. pyogenes: 0.58-0.69 x 10(7) CFU/ml, K. pneumoniae: 18.71-20.26 x 10(7) CFU/ml and E. coli: 1.78-2.10 x 10(7) CFU/ml. Conclusion The study was undertaken as a proof of principle with the aim to demonstrate (i) the quality, stability and suitability of the bacterial strains for low-titre spiking of blood components, (ii) the property of donor-independent proliferation in PCs, and (iii) their suitability for worldwide shipping of deep frozen, blinded pathogenic bacteria. These aims were successfully fulfilled. The WHO Expert Committee Biological Standardisation has approved the adoption of these four bacteria strains as the first Repository for Transfusion-Relevant Bacteria Reference Strains and, additionally, endorsed as a project the addition of six further bacteria strain preparations suitable for control of platelet contamination as the next step of enlargement of the repository. C1 [Stoermer, M.; Brachert, J.; Hanschmann, K. -M.; Schneider, C. K.; Sicker, U.; Montag, T.] Paul Ehrlich Inst, Sect Microbial Safety, D-63225 Langen, Germany. [Arroyo, A.; Rojo, J.] Ctr Nacl Transfus Sanguinea, Mexico City, DF, Mexico. [Carrero, H.; Heath, D. G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Devine, D.; Ramirez-Arcos, S.] Canadian Blood Serv, Ottawa, ON, Canada. [Epstein, J. S.] US FDA, Rockville, MD 20857 USA. [Gabriel, C.] Austrian Red Cross, Blutzentrale Linz, Austria. [Gelber, C.; McKee, M.] Amer Type Culture Collect, Manassas, VA USA. [Goodrich, R.; Keil, S.; Marschner, S.] CaridianBCT Biotechnol, Lakewood, CO USA. [Jacobs, M. R.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [de Korte, D.; Marcelis, J.; Rood, I.] Sanquin Blood Supply Fdn, Amsterdam, Netherlands. [Lambrecht, B.; Mueller, T. H.] NSTOB, German Red Cross, Springe, Germany. [Lee, C. -K.] Hong Kong Red Cross Blood Transfus Serv, Hong Kong, Hong Kong, Peoples R China. [McDonald, C.; McGuane, S.] NHS Blood & Transplant, London, England. [Muthivhi, T.] S African Natl Blood Serv, Weltevreden Pk, South Africa. [Pettersson, A.] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands. [Radziwon, P.] Reg Ctr Transfus Med, Bialystok, Poland. [Reesink, H. W.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Schmidt, M.; Seifried, E.] German Red Cross, Frankfurt, Germany. [Wendel, S.] Hosp Sirio Libanes, Sao Paulo, Brazil. [Wood, E. M.] Australian Red Cross Blood Serv, Melbourne, Vic, Australia. [Yomtovian, R. A.] Louis Stokes Vet Adm Med Ctr, Cleveland, OH USA. RP Stormer, M (reprint author), Paul Ehrlich Inst, Sect Microbial Safety, Paul Ehrlich Str 51-59, D-63225 Langen, Germany. EM Melanie.Stoermer@pei.de RI Gabriel, Christian/A-1689-2014 OI Gabriel, Christian/0000-0003-2043-9320 NR 35 TC 16 Z9 16 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0042-9007 J9 VOX SANG JI Vox Sang. PD JAN PY 2012 VL 102 IS 1 BP 22 EP 31 DI 10.1111/j.1423-0410.2011.01510.x PG 10 WC Hematology SC Hematology GA 869MO UT WOS:000298602400004 PM 21732948 ER PT J AU Gazonas, GA Velo, AP AF Gazonas, G. A. Velo, A. P. TI Analytical solutions for the resonance response of Goupillaud-type elastic media using z-transform methods SO WAVE MOTION LA English DT Article DE Stress amplitude; Palindromic polynomials; Travel-time variable; Chebyshev polynomial; Natural frequency formula; Analog to digital conversion ID TRIDIAGONAL MATRICES; WAVES; REFLECTION; VIBRATIONS; SYSTEMS AB The resonance frequency spectrum is first derived for an m-layered Goupillaud-type elastic medium that is subjected to a discrete sinusoidal forcing function that varies harmonically with time at one end and held fixed at the other end. Analytical stress solutions are obtained from a coupled first-order system of difference equations using z-transform methods, where the determinant of the resulting global system matrix in the z-space |A(m)| is a palindromic polynomial with real coefficients. The zeros of the palindromic polynomial are distinct and are proven to lie on the unit circle for 1 <= m <= 5 and for certain classes of multilayered designs identified by tridiagonal Toeplitz matrices. An important result is the physical interpretation that all the positive angles, coterminal with the angles corresponding to the zeros of |A(m)| on the unit circle, represent the resonance frequency spectrum for the discrete model. A sequence of resonance frequencies for the discrete model appears to be universal for all multilayered designs with an odd number of layers, as it is independent of any design parameters. The resonance frequency results for the discrete model are then extended to describe the resonance frequency spectrum for the continuous model, where the forcing function applied at one end of the strip is continuous and varies harmonically with time while the other end is held fixed. The proposed natural frequency spectrum for a free-fixed m-layered Goupillaud-type strip is confirmed by independently solving a simplified form of the frequency equation, obtained after applying a transformation of the spatial variable. Our results suggest that the natural frequency spectrum depends on the layer impedance ratios and it is inversely proportional to the equal wave travel time for each layer. The results are used to identify layered designs with a common frequency spectrum and modify an existing design to obtain a desired frequency spectrum. Other connections are made with previous stress optimization results, the Chebyshev polynomials of the first and second kind, as well as the natural frequencies of a free-fixed non-Goupillaud-type layered strip. Published by Elsevier By. C1 [Gazonas, G. A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Velo, A. P.] Univ San Diego, Dept Math & Comp Sci, San Diego, CA 92110 USA. RP Gazonas, GA (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM george.a.gazonas.civ@mail.mil OI Gazonas, George/0000-0002-2715-016X FU US Army Research Laboratory [W911NF-07-D-0001] FX We would like to thank Dr. Raymond Wildman at the US Army Research Laboratory, Aberdeen Proving Ground, Maryland, for valuable discussions regarding precision and accuracy of the numerical results presented in this paper. This research effort was partially sponsored by the Short Term Analysis Services (STAS) Pro-gram, administered by the Battelle Memorial Institute in North Carolina for the US Army Research Laboratory under contract No. W911NF-07-D-0001. NR 29 TC 4 Z9 4 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2125 EI 1878-433X J9 WAVE MOTION JI Wave Motion PD JAN PY 2012 VL 49 IS 1 BP 135 EP 151 DI 10.1016/j.wavemoti.2011.08.002 PG 17 WC Acoustics; Mechanics; Physics, Multidisciplinary SC Acoustics; Mechanics; Physics GA 868MO UT WOS:000298527600010 ER PT J AU Stevens, K Stojadinovic, A Helou, LB Solomon, NP Howard, RS Shriver, CD Buckenmaier, CC Henry, LR AF Stevens, Kristin Stojadinovic, Alexander Helou, Leah B. Solomon, Nancy P. Howard, Robin S. Shriver, Craig D. Buckenmaier, Chester C. Henry, Leonard R. TI The impact of recurrent laryngeal neuromonitoring on multi-dimensional voice outcomes following thyroid surgery SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE voice; thyroidectomy; neuromonitoring ID NERVE INJURY; SEVERITY INDEX; RISK; PREVALENCE; PARALYSIS; DISEASE AB Background Voice changes after thyroidectomy are common but not always related to recurrent laryngeal nerve (RLN) injury. We evaluated if RLN neuromonitoring correlated with non-RLN injury-related changes in voice after thyroidectomy. Methods: Prospective multi-dimensional voice assessment was conducted on patients undergoing thyroidectomy before, 1-4 weeks, and 6 months postoperatively. Voice outcome (VO) was determined as normal (NormVO) or negative (NegVO) based upon combinations of patient-reported symptoms, videolaryngoscopy, a composite of acoustic measurements, and clinician-perceived voice quality. Groups with and without neuromonitoring were compared for early and durable differences in VO. Results: Ninety-one patients underwent thyroidectomy; 39 with RLN neuromonitoring and 52 without. The two study groups were similar with regard to baseline characteristics including voice assessment. There was no difference in NegVO between neuromonitored and nonmonitored patients at 1-4 weeks (n = 89; 32% vs. 27%; P = 0.81) and 6 months (n = 71, 14% vs. 7%; P = 0.42) after thyroidectomy. Neuromonitoring was associated with a 48-min increase in median operative time, but this finding was not statistically significant in a multivariate model. Conclusion: In this study, recurrent laryngeal neuromonitoring did not appear to influence non-RLN injury related VO as measured by a comprehensive multidimensional voice assessment. J. Surg. Oncol. 2012;105:4-9. (C) 2011 Wiley Periodicals, Inc. C1 [Henry, Leonard R.] Indiana Univ Hlth, Goshen Ctr Canc Care, Goshen, IN 46526 USA. [Stevens, Kristin] USN, Med Res Ctr, Silver Spring, MD USA. [Stevens, Kristin] USN, San Diego Med Ctr, San Diego, CA 92152 USA. [Stojadinovic, Alexander] US Mil Canc Inst, Walter Reed Army Med Ctr, Dept Surg, Washington, DC USA. [Shriver, Craig D.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Dept Surg, Bethesda, MD 20814 USA. [Helou, Leah B.] Univ Pittsburgh, Dept Commun Sci & Disorders, Pittsburgh, PA USA. [Solomon, Nancy P.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Biostat Sect, Washington, DC 20307 USA. [Buckenmaier, Chester C.] USA, Reg Anesthesia & Pain Management Initiat, Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20310 USA. RP Henry, LR (reprint author), Indiana Univ Hlth, Goshen Ctr Canc Care, 200 High Pk Ave, Goshen, IN 46526 USA. EM lhenry@iuhealth.org FU The Department of the Army Congressional Program; Army Regional Anesthesia and Pain Management Initiative FX The views expressed herein are those of the authors and do not necessarily reflect the policy or position of the US Navy, US Army, Department of Defense, or the US Government. The data presented here come from a prospective longitudinal trial which has resulted in multiple prior publications. The Department of the Army Congressional Program Grant, Army Regional Anesthesia and Pain Management Initiative provided partial support for this research. NR 32 TC 13 Z9 14 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD JAN PY 2012 VL 105 IS 1 BP 4 EP 9 DI 10.1002/jso.22063 PG 6 WC Oncology; Surgery SC Oncology; Surgery GA 860MP UT WOS:000297952700002 PM 21882195 ER PT J AU Altgilbers, LL Stults, AH Shkuratov, S Baird, J Alberta, E AF Altgilbers, L. L. Stults, A. H. Shkuratov, S. Baird, J. Alberta, E. BE Kiuttu, GF Struve, KW Degnan, JH TI FERROELECTRIC GENERATORS SO 2012 14TH INTERNATIONAL CONFERENCE ON MEGAGAUSS MAGNETIC FIELD GENERATION AND RELATED TOPICS (MEGAGUSS) LA English DT Proceedings Paper CT 14th International Conference on Megagauss Magnetic Field Generation and Related Topics (MEGAGAUSS) CY OCT 14-19, 2012 CL Maui, HI SP IEEE, MG Inst Inc, US & Russian labs, European & Chinese labs, IEEE Nucl & Plasma Sci Soc, IEEE Pulsed Power Sci & Technol Comm DE ferroelectric; explosives; lead zirconate titanate; PZT; pulsed power ID SHOCK; RESISTIVITY AB Ferroelectric Generators (FEGs) are compact single shot high voltage generators. They consist of a small explosive charge, ferroelectric ceramic, and an output circuit. There has been and continues to be active Small Business Innovative Research (SBIR), University, and Government programs to develop FEGs as very compact power supplies for a variety of loads including antennas, microwave sources, and detonator arrays. In this paper, we will report on some of our recent efforts to improve the performance of FEGs and to use them to drive various loads. C1 [Altgilbers, L. L.] US Army Space & Missile Def Command, Army Forces Strateg Command, Huntsville, AL 35898 USA. [Stults, A. H.] US Army Aviat & Missile Res, Ctr Dev & Engn, Huntsville, AL USA. [Shkuratov, S.; Baird, J.] Loki Inc, Rolla, MO USA. [Alberta, E.] TRS Technol, State Coll, PA USA. RP Altgilbers, LL (reprint author), US Army Space & Missile Def Command, Army Forces Strateg Command, Huntsville, AL 35898 USA. EM allen.stults@us.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-5720-3 PY 2012 PG 8 WC Engineering, Electrical & Electronic SC Engineering GA BG9IT UT WOS:000393288600032 ER PT J AU Altgilbers, L AF Altgilbers, Larry BE Kiuttu, GF Struve, KW Degnan, JH TI Early History of Explosive Pulsed Power: 1943-1970 SO 2012 14TH INTERNATIONAL CONFERENCE ON MEGAGAUSS MAGNETIC FIELD GENERATION AND RELATED TOPICS (MEGAGUSS) LA English DT Proceedings Paper CT 14th International Conference on Megagauss Magnetic Field Generation and Related Topics (MEGAGAUSS) CY OCT 14-19, 2012 CL Maui, HI SP IEEE, MG Inst Inc, US & Russian labs, European & Chinese labs, IEEE Nucl & Plasma Sci Soc, IEEE Pulsed Power Sci & Technol Comm DE pulsed power; flux compression; ferroelectric; high explosives AB Explosive driven magnetic compression was first proposed by J.L. Fowler and Woodward in late 1943 at the Los Alamos National Laboratory (LANL) during the Manhattan project. Implosion of a liner immersed in an external magnetic field would generate a signal that could be detected with a pickup coil. The objective was to measure the rate of implosion of the liner. The first flux compression experiment was conducted by J.L. Fowler on January 4, 1944. An analysis of the data from these experiments showed that the fields were compressed from a few gauss to a few hundred gauss. By June 1944, J.L. Fowler and his team were getting reproducible scope traces for imploding cylinders and spheres that were in good agreement with other diagnostic methods. This was the genesis for the work later carried out by C.M. Fowler at Los Alamos. In addition to LANL, there were several other Flux Compression Generator (FCG) programs conducted at various universities and organizations in the 1960s including Davidson Laboratory of the Stevens Institute of Technology for Picatinny Arsenal, Poulter Laboratories of the Stanford Research Institute for the Air Force Systems Command, Illinois Institute of Technology (ITT) for the Army Research Office, and Aerojet Corporation. Other countries including Russia, China, France, Italy, and England had established FCG programs in the 1950s and 1960s. In 1957, F.W. Neilson designed, built, and tested both Ferroelectric Generators (FEGs) and Ferromagnetic Generators (FMGs) at Sandia National Laboratory (SNL). This led to programs at Sandia in the 1960s to develop compact single shot power supplies. In addition, explosive driven FEGs were investigated by other others such as M.F. Rose, W.L. Gilbertson, and others at the Naval Surface Weapons Center, P.E. Houser at Picatinny Arsenal, and W.L. Baker at the Air Force Weapons Laboratory. In this paper, we will review FCG and FEG programs that occurred in the U.S. and other countries during the period ranging from 1943 - 1970. C1 [Altgilbers, Larry] US Army, Space & Missile Def Command, Army Strateg Forces Command, Huntsville, AL 35816 USA. RP Altgilbers, L (reprint author), US Army, Space & Missile Def Command, Army Strateg Forces Command, Huntsville, AL 35816 USA. EM larry.altgilbers@smdc.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4673-5720-3 PY 2012 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA BG9IT UT WOS:000393288600001 ER PT S AU Chen, Y Nasrabadi, NM Tran, TD AF Chen, Yi Nasrabadi, Nasser M. Tran, Trac D. GP IEEE TI DISCRIMINATIVE DICTIONARY DESIGN USING LVQ FOR HYPERSPECTRAL IMAGE CLASSIFICATION SO 2012 4TH WORKSHOP ON HYPERSPECTRAL IMAGE AND SIGNAL PROCESSING (WHISPERS) SE Workshop on Hyperspectral Image and Signal Processing LA English DT Proceedings Paper CT 4th Workshop on Hyperspectral Image and Signal Processing - Evolution in Remote Sensing (WHISPERS) CY JUN 04-07, 2012 CL Shanghai, PEOPLES R CHINA SP IEEE Geoscience & Remote Sensing Soc, HySpex, ASD, EXELIS, Itres, Golden Way Sci, ESRI, NBL ID SPARSE REPRESENTATION AB In this paper, we propose a new technique for discriminative dictionary learning for hyperspectral image classification. The proposed algorithm generalizes the learning vector quantization scheme for sparse representation-based classifiers. It is known that a pixel can be represented by a sparse linear combination of atoms in a dictionary and its sparse representation vector contains the class information. The proposed learning technique utilizes the discriminative nature of the sparse vectors in the dictionary updating stage, generating a dictionary with both reconstructive and discriminative capabilities. Experimental results on a real hyperspectral data set demonstrate that using dictionaries learned from the proposed technique improves classification performance in various conditions C1 [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, 3400 N Charles St, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Chen, Y (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, 3400 N Charles St, Baltimore, MD 21218 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2158-6268 BN 978-1-4799-3406-5 J9 WORK HYPERSP IMAG PY 2012 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing; Telecommunications SC Engineering; Remote Sensing; Telecommunications GA BB7MO UT WOS:000345747000070 ER PT S AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung GP IEEE TI OPTIMAL SPARSE KERNEL LEARNING IN THE EMPIRICAL KERNEL FEATURE SPACE FOR HYPERSPECTRAL CLASSIFICATION SO 2012 4TH WORKSHOP ON HYPERSPECTRAL IMAGE AND SIGNAL PROCESSING (WHISPERS) SE Workshop on Hyperspectral Image and Signal Processing LA English DT Proceedings Paper CT 4th Workshop on Hyperspectral Image and Signal Processing - Evolution in Remote Sensing (WHISPERS) CY JUN 04-07, 2012 CL Shanghai, PEOPLES R CHINA SP IEEE Geoscience & Remote Sensing Soc, HySpex, ASD, EXELIS, Itres, Golden Way Sci, ESRI, NBL DE Sparse kernel learning; Optimal feature selection; Empirical kernel feature space; Empirical kernel map AB In this paper, we present a novel framework for sparse kernel learning in a finite space called the Empirical Kernel Feature Space (EKFS). The EKFS can be explicitly built by using any positive definite kernel including Gaussian RBF kernel via an empirical kernel map. In order to turn the empirical kernel map into a feature map associated with a kernel, EKFS is endowed with the dot product of a map associated with the correponding whitened EKFS. In previous sparse kernel learning techniques, subsets of features were selected from the original input feature space. This method was optimal up to the linear kernel. In this work, feature subset selection is performed in the EKFS which leads to the selection of corresponding Reproducing Kernel Hilbert Space (RKHS). Both the EKFS and the corresponding RKHS have the same geometrical structure. The proposed sparse kernel learning can optimally select multiple subsets of newly mapped features in the EKFS in order to improve the generalization performance of the classifier. The sparse kernel-based learning is tested on several hyperspectral data sets and a performance comparison among different feature selection techniques is presented. C1 [Gurram, Prudhvi] MBO Partners, 13454 Sunrise Valley Dr,Suite 300, Herndon, VA 20171 USA. [Kwon, Heesung] US Army Res Lab, ATTN RDRL SES E, Adelphi, MD 20783 USA. RP Gurram, P (reprint author), MBO Partners, 13454 Sunrise Valley Dr,Suite 300, Herndon, VA 20171 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2158-6268 BN 978-1-4799-3406-5 J9 WORK HYPERSP IMAG PY 2012 PG 4 WC Engineering, Electrical & Electronic; Remote Sensing; Telecommunications SC Engineering; Remote Sensing; Telecommunications GA BB7MO UT WOS:000345747000053 ER PT S AU Arnett, KP Quadrato, CE AF Arnett, Kevin P. Quadrato, Craig E. GP ASEE TI BUILDING INFORMATION MODELING: DESIGN INSTRUCTION BY INTEGRATION INTO AN UNDERGRADUATE CURRICULUM SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB Building Information Modeling (BIM) developed into a prominent field of knowledge and practice in the Architect/Engineering/Construction (AEC) profession over the past decade. As this field emerged in both academia and industry, increasingly viewed as critical for significant practice, the state of the art became more clearly defined. As the field matures, the door opens for the effective integration of BIM at the undergraduate civil engineering program level. Some universities have taken the approach of addressing this new body of knowledge via seminar sessions, in addition to the standard academic load, while others have addressed the need with the development of a specific course devoted solely to BIM. The seminar approach evolved early when the topic was new. This approach is not as comprehensive and consequently not as demanding a commitment for both students and faculty alike. The alternative of creating an additional course adds BIM to the list of compulsory or elective courses and offers the opportunity for in depth learning on the topic. This provides a significant focus on the topic and builds on prior knowledge, but requires an additional course load for both students and faculty; the new course results in treatment of BIM as a separate specialty rather than a method to connect engineering disciplines. A third approach is possible now that time allowed BIM concepts to become more standardized is to integrate BIM fundamentals throughout the complementary courses in an undergraduate civil engineering program. Integration creates the advantage of directly linking BIM to work in existing courses and highlights BIM in its normal state as a condition of the engineering environment rather than a separate subject. And while uniting coursework in a common BIM software platform offers significant advantages from a program perspective, simply using consistent BIM concepts in courses may also have a significantly positive effect on the undergraduate experience, specifically in capstone design courses. An initial implementation of this integrated approach is presented and evaluated in this paper based on the experiences in the civil engineering program at the United States Military Academy. C1 [Arnett, Kevin P.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Quadrato, Craig E.] US Mil Acad, West Point, NY 10996 USA. RP Arnett, KP (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 23 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 16 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AS UT WOS:000380250105051 ER PT S AU Barry, PEBE Katalenich, MSM Mccoy, MBC AF Barry, Brock E. P. E. Katalenich, Major Scott M. Mccoy, Major Brad C. GP ASEE TI Student Perceptions of the Civil Engineering Body of Knowledge: Comparison of Two Academic Institutions SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE C1 [Barry, Brock E. P. E.; Katalenich, Major Scott M.; Mccoy, Major Brad C.] US Mil Acad, West Point, NY USA. RP Barry, PEBE (reprint author), US Mil Acad, West Point, NY USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 18 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AU UT WOS:000380253700015 ER PT S AU Crawford, BG Farrell, S Bristow, E AF Crawford, Bobby G. Farrell, Stephanie Bristow, Elizabeth GP ASEE TI PROFESSEURS SANS FRONTIERES: SPREADING FACULTY KNOWLEDGE AND EXPERIENCE AROUND THE WORLD SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB Engineering education is a global enterprise. Nowhere is that more evident than in countries where there is a severe shortage of this invaluable commodity. A study of the war in Afghanistan in an attempt to isolate the root causes of this conflict invariably points to the lack of education among the populace which serves as a breeding ground for extremists and insurgent indoctrination. In his book, Three Cups of Tea, Greg Mortenson describes the motivation for his campaign of promoting peace through education as follows: "If we try to resolve terrorism with military might and nothing else, then we will be no safer than we were before 9/11. If we truly want a legacy of peace for our children, we need to understand that this is a war that will ultimately be won with books, not with bombs." A by-product of the poor educational system is a shortage of engineers and the accompanying poor state of civil infrastructure that permeates the country. In addressing this problem, the national leadership of Afghanistan is working to reinvigorate the country's university system. Part of that effort has been the establishment of the National Military Academy of Afghanistan (NMAA); a four-year, bachelor degree granting institution modeled after the military academies of the United States. Two of the primary degrees offered by NMAA are in Civil and General Engineering. In the summer of 2009, faculty members from the United States Military Academy (USMA) traveled to NMAA to serve as mentors for the budding Academy. This same principle applies beyond Afghanistan. There is a continuing need for engineering expertise and education in Nicaragua, India and elsewhere. Engineering faculty and students today can expect to work on projects far beyond the borders of their home countries, in settings ranging from villages in the developing world to the most modern of cities. The mental and cultural dexterity required to work in widely diverse environments is seldom explicitly taught, but nevertheless it must be learned. Students may gain international experience through study-abroad programs or service-learning programs in developing communities and professors may foster student development by including their own international work experiences in classroom lectures and discussions. This paper gives a brief overview of various outreach activities to Afghanistan, Nicaragua and India. It discusses the authors' activities abroad, describes some of the varying needs, and conveys lessons learned and issues which must be considered when conducting this type of global outreach. It describes a practical application of learning theory as well as the teaching and reinforcement of that theory as part of continuing faculty development in both emerging and developed educational systems. It also discusses the augmentation of student education through a formal service learning program conducted through Engineers Without Borders. C1 [Crawford, Bobby G.] US Mil Acad, Mech Engn Program, West Point, NY 10996 USA. [Farrell, Stephanie] Rowan Univ, Chem Engn, Glassboro, NJ 08028 USA. [Bristow, Elizabeth] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Crawford, BG (reprint author), US Mil Acad, Mech Engn Program, West Point, NY 10996 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 17 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AU UT WOS:000380253702051 ER PT S AU Evangelista, MJW AF Evangelista, Major John W. GP ASEE TI AC 2012-3902: EXAMINING AND INFLUENCING HOW STUDENTS PREPARE FOR ENGINEERING CLASSES SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB A common stigma that students often associate with an engineering degree is enduring an excessive workload. In fact, recent studies suggest that this perception is one of the primary reasons many students leave engineering majors and pursue other studies. This claim is also confirmed almost uniformly across all core engineering courses when students report on end of course surveys that they do not have enough time in their schedule to complete their assignments. As an educator, however, these claims are viewed from an admittedly critical perspective, especially after witnessing first-hand, frustratingly at times, poor study habits, weak time management skills and unacceptable daily preparation levels for class. In fact, this contradiction is highlighted further by a unique departmental policy requiring students to anonymously report how much time they spend preparing for each lesson. Each year, students report that they are actually spending on average just half the amount of time per lesson that is both expected and also used to design course requirements. So is it really fair, or even accurate, to label engineering with an "excessive workload" compared to other disciplines? As an educator, the potential to positively influence this apparent contradictory stigma and obvious source of frustration for both student and teacher forms the primary motivation of this study. This work examines how engineering students actually spend their time preparing for class and how we as teachers can positively influence it. The first objective investigates the true nature of student preparation. We explore if students actually complete or at least review assigned readings and what encourages them to do so. We evaluate how graded events drive student preparation and how much time is truly being spent preparing for class. The second objective evaluates certain teaching methods that reportedly enhance student preparation and learning. As a pilot study, our primary method requires students in a previously open-book-exam heat transfer course to rely on their own daily summary notes for all graded events. Students submit a summary outline from the reading within the front half of a sheet of paper for each lesson. Only sheets demonstrating completion of the assigned reading are approved and given back to students where additional notes can be written within the remaining space on the sheet of paper. Most importantly, this document serves as the student's primary reference on examinations. Initial results show this method is administratively simple to implement and class preparation time, along with completion rates of assigned readings are noticeably higher compared to other core engineering courses. We feel this study will be of interest to educators in any technical field looking for a simple, "self-motivating" tool to enhance student preparation and learning. C1 [Evangelista, Major John W.] US Mil Acad, West Point, NY 10996 USA. RP Evangelista, MJW (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 14 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AT UT WOS:000380252701044 ER PT S AU Klosky, JL Katalenich, SM Hart, SD AF Klosky, J. Ledlie Katalenich, Scott M. Hart, Steven D. GP ASEE TI REQUIRING A COURSE IN INFRASTRUCTURE FOR ALL GRADUATES SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB There is something universal about obtaining a degree from an accredited university; it is a license to call oneself educated. In recognizing this certification of erudition, society sets relatively simple standards that can be difficult to achieve. The graduate must be able to address difficult problems coherently, bringing to bear a mixture of knowledge, empathy, skills, and moral and ethical standards. Within this framework, society allows for specialization. Lawyers are not asked to design airplanes nor doctors to write complex opinions on the meaning of recent acts of Congress. There is, however, an underlying expectation of core knowledge which is inescapable. Any college graduate, for example, should be able to read or write a paper on a complex topic, illustrating or discerning both the obvious and implied elements. To provide the underpinnings for this task, essentially every university requires a course in composition, and usually more than one; science and mathematics are likewise added to the core to ensure a universal base of knowledge among the graduates. All of these core competencies help graduates understand and explain elements of their everyday life, and are broadly considered essential to their ability to lead society towards a better future, achieving what is often the stated goal of each university. But if universities are producing leaders for society, shouldn't those leaders have an understanding of infrastructure, of the basic foundational technologies of society? Flip a switch, turn a valve, flush a toilet or climb aboard and travel - can the typical college graduate explain the implications of that action? Do they know what makes it work and the systems enabling them? If one can appreciate art and thus build a deeper understanding of the world, couldn't Infrastructure Appreciation help build more complete citizens of the world, laying the groundwork for a broader view of the choices civilizations make? This paper builds on previous work, which described only the content of a specific course. Here, the authors discuss the need for widely available, and perhaps required, courses in the area of infrastructure. By providing all students with an understanding of how the built environment forms an essential part of societies past and present, our universities would creat graduates ready to lead society's critically important discussions and decisions, creating a future that we can best imagine collaboratively, including all the disciplines brought together by a shared base of knowledge. C1 [Klosky, J. Ledlie; Hart, Steven D.] US Mil Acad, West Point, NY 10996 USA. [Katalenich, Scott M.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Klosky, JL (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 12 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AU UT WOS:000380253702078 ER PT S AU Meyer, KF Estes, AC Mlakar, PF AF Meyer, Karl F. Estes, Allen C. Mlakar, Paul Francis GP ASEE TI CIVIL ENGINEERING PROGRAM EVALUATOR REFLECTIONS: THE MOST RECENT LESSONS LEARNED SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB For the 2011-2012 ABET accreditation cycle, a number of changes across the criteria have impacted the way in which programs must approach their accreditation efforts. 1 The most significant change is related to the reporting of assessment activities and their use for program improvement. For the first time this year, assessment results of program educational objectives and student outcomes are reported in Criterion 4, Continuous Improvement. Additionally, there have been changes to the former Criterion 9, Program Criteria. The Program Criteria is no longer numbered, but more importantly, contains some fairly significant changes impacting the assessment of student performance. The changes include no longer requiring programs to specifically incorporate the program criteria in their student outcomes and no longer requiring programs to assess the degree to which students are achieving the program criteria. The purpose of this paper is to capture the experiences of three Civil Engineering Program Evaluators who have visited programs with differing characteristics during this accreditation cycle. It takes the reader from initial contact with the program chair through review of the self study and student transcripts to the on-site visit and offers lessons learned on how to best meet the current ABET Criteria and prepare for an ABET visit. C1 [Meyer, Karl F.] US Mil Acad, Civil Engn Div, West Point, NY 10996 USA. [Meyer, Karl F.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. [Estes, Allen C.] Calif Polytech State Univ San Luis Obispo, Architectural Engn Dept, San Luis Obispo, CA 93407 USA. [Mlakar, Paul Francis] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Meyer, KF (reprint author), US Mil Acad, Civil Engn Div, West Point, NY 10996 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 9 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AS UT WOS:000380250105038 ER PT S AU Pfluger, AR Roux, DMP Butkus, MA AF Pfluger, Andrew Ross Roux, David-Michael P. Butkus, Michael A. GP ASEE TI A HANDS-ON EXPERIENCE IN AIR POLLUTION ENGINEERING COURSES: IMPLEMENTING AN EFFECTIVE INDOOR AIR POLLUTION PROJECT SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB Many undergraduate environmental engineering programs have courses on air pollution engineering; however, most of these courses do not include a hands-on learning experience. This shortcoming can influence ABET accreditation since the Environmental Engineering Program Criterion (Criterion 9) states that students must have an ability to conduct laboratory experiments, critically analyze, and interpret data in more than one major environmental engineering focus area, e.g., air, water, land, environmental health. Additionally, ABET outcome "b" states that graduates will develop the skills necessary to plan, design, execute, and critically interpret results from experiments. Students in the Environmental Engineering Program at the United States Military Academy have water-related laboratory experiences in lower- level courses, such as jar testing and biochemical oxygen demand experiments, similar to those found in many undergraduate environmental engineering programs at other universities. This work presents an indoor air pollution project that provides students an opportunity to develop and test a hypothesis related to an indoor air quality issue that interests them. The methods and materials required to implement this educational experience in environmental engineering programs to meet ABET accreditation requirements are also presented. Preparation for the project requires student teams (3-4 students) to develop a basic evaluation and sampling protocol to test a potential indoor air pollution problem. Students identify a pollutant of concern, either a gas (CO, Cl, VOC, Radon, O-3, etc.) or particulate matter, and identify a feasible and safe location on campus for testing. Student teams are required to submit a 5-page technical report on their methods and findings and must compare the concentration of pollutants they detect to the Permissible Exposure Limits (PEL) for occupational exposure to indoor air pollutants established by the National Institute for Occupational Safety and Health. Students receive feedback on their protocols and results from their customer, their instructor, and the environmental engineering lab manager. C1 [Pfluger, Andrew Ross; Roux, David-Michael P.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Butkus, Michael A.] US Mil Acad, Environm Engn, West Point, NY 10996 USA. RP Pfluger, AR (reprint author), US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 15 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AS UT WOS:000380250100028 ER PT S AU Ressler, SJ AF Ressler, Stephen J. GP ASEE TI TO RAISE THE BAR OR NOT: ADDRESSING THE OPPOSITION SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE C1 [Ressler, Stephen J.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Ressler, SJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 18 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AU UT WOS:000380253704066 ER PT S AU Ressler, SJ AF Ressler, Stephen J. GP ASEE TI THE RAISE THE BAR INITIATIVE: CHARTING THE FUTURE BY UNDERSTANDING THE PATH TO THE PRESENT - ACCREDITATION CRITERIA SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE C1 [Ressler, Stephen J.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Ressler, SJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 22 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AU UT WOS:000380253704065 ER PT S AU Sanborn, MJ Purchase, KT Barry, BE AF Sanborn, Marc J. Purchase, Kathryn T. Barry, Brock E. GP ASEE TI KICKING OUT THE CRUTCH: THE IMPACT OF FORMULA SHEETS ON STUDENT PERFORMANCE AND LEARNING SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE ID BOOK TESTS AB This paper reports the results of a study of the impact of examination reference materials on student performance and retention. To evaluate performance, within-term and final examination mean scores are compared from two populations of students in a statics and mechanics of materials introductory-level engineering course. One population (n=184) was provided reference material for use on examinations. The second population (n=201) was not permitted to use any reference material on examinations. Retention was evaluated using a test-retest assessment by comparing final examination mean scores and a concept inventory survey. Finally, student preparation time is compared using time survey data. No definitive conclusions can be made about the impact the reference cards had on performance or retention. However, student preparation time and overall performance was not negatively impacted in the population without reference materials. The motivation behind this study and the theory behind using reference materials are also discussed. C1 [Sanborn, Marc J.; Purchase, Kathryn T.; Barry, Brock E.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Sanborn, MJ (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 21 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 19 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AT UT WOS:000380252704021 ER PT S AU Toth, JA Hanus, JP AF Toth, Jason Allen Hanus, Joseph P. GP ASEE TI AC 2012-3554: CONTINUED ASSESSMENT OF INFORMATION TECHNOLOGY SOFTWARE INTEGRATION IN A CIVIL ENGINEERING PROGRAM SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB Aptitude and skills in information technology remain critical in the Civil Engineering profession. Recognizing this, many universities include the development of information technology knowledge in their vision and goals, as well as their ABET outcomes and objectives. The Civil Engineering program at the United States Military Academy (USMA) is one such university. Since 2007, the program has included industry-leading software from Autodesk and Bentley. The software has been introduced in a site design course, used in follow-on courses, and integrated into the program's capstone course. Because of USMA's commitment to the development of cognitive, affective, and psychomotor skills with information technology, there has been a continuous study on the numerous and unique challenges associated with integrating such technologies into their courses and programs. An initial report provided a synopsis of efforts over the initial three semester's time (2007-2008) and this paper will report on the follow-on study. Further assessment, new approaches, and a comparison of methods will be discussed all using the same framework of three student development domains: cognitive, affective, and psychomotor. In so doing this new study will serve as a follow-up discussion on how the Civil Engineering Program at USMA continues to meet these challenges and how the solutions can be applied in others programs. C1 [Toth, Jason Allen; Hanus, Joseph P.] US Mil Acad, Dept Civil Engn, West Point, NY 10996 USA. RP Toth, JA (reprint author), US Mil Acad, Dept Civil Engn, West Point, NY 10996 USA. NR 23 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 20 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AS UT WOS:000380250104050 ER PT S AU Wade, BM Rabb, RJ Mcvay, MRC Hanlon, P AF Wade, Brian M. Rabb, Robert J. Mcvay, Major R. Clayton Hanlon, Peter GP ASEE TI ADJUSTING STUDENT TEST PREPARATION THROUGH THEIR OWN SELF-ASSESSMENT SO 2012 ASEE ANNUAL CONFERENCE SE ASEE Annual Conference & Exposition LA English DT Proceedings Paper CT ASEE Annual Conference CY JUN 10-13, 2012 CL San Antonio, TX SP ASEE AB Students must prepare for life-long learning. This paper presents a means to directly assess student test preparation in both a senior level control engineering course as well as an introductory thermodynamics course. Student performance shows that certain study materials and activities are more effective for success in a given course. In this study, students document and record their own test preparation to include both the activity and the duration. They are then shown an anonymous graph of the overall class grades as a function of the test preparation activity. The students compare their study habits and grades with their peers to determine if other study tactics resulted in better grades. This allows students to adjust their test preparation activities throughout the semester. Their exposure to these more frequent and smaller point scale tests allow for adjustments before their grades become too difficult to change. The overall assessment of the study's effectiveness includes course surveys from the students, the scores on the tests, and final exams. The results show that students' test preparation activities can be influenced and that the students learn to study more efficiently. This increased efficiency actually leads to increased learning. C1 [Wade, Brian M.; Rabb, Robert J.; Mcvay, Major R. Clayton; Hanlon, Peter] US Mil Acad, West Point, NY 10996 USA. RP Wade, BM (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 7 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC ENGINEERING EDUCATION PI WASHINGTON PA 1818 N STREET, NW SUITE 600, WASHINGTON, DC 20036 USA SN 2153-5965 J9 ASEE ANNU CONF EXPO PY 2012 PG 14 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BF1AS UT WOS:000380250100022 ER PT S AU Tagliente, DA AF Tagliente, Daniel A. GP IEEE TI Low-Cost and Small Footprint Solution for Testing Low-Voltage Differential Signal Video Displays SO 2012 IEEE AUTOTESTCON PROCEEDINGS SE IEEE Autotestcon LA English DT Proceedings Paper CT IEEE Autotestcon Conference CY SEP 10-13, 2012 CL Anaheim, CA SP Inst Elect & Elect Engineers, IEEE Instrumentat & Measurement Soc, AESS, Disneyland, IEEE Aerosp & Electr Syst Soc DE LVDS; video; display; test generation; LCD; display; diagnostics; video transmission; low-voltage differential signaling AB In recent years, liquid crystal displays (LCD) have almost completely replaced older technologies such as cathode ray tube (CRT) displays in many industrial, commercial, aerospace, and military applications due to their increased efficiency, decreased weight, and smaller size. Likewise, the technology used to transmit video signals to LCD displays has evolved from analog standards such as the National Television Standards Council's (NTSC) RS-170 standard and the Phase Alternating Line (PAL) standard to higher speed digital standards such as the Digital Visual Interface (DVI) standard, High-Definition Multimedia Interface (HDMI) standard, and low-voltage differential signaling (LVDS) standard. This evolution of video standards has created a need for the test environments and test generation devices used to test video displays to mature as well. LVDS, defined by the Telecommunications Industry Association (TIA) TIA/EIA-644 and Institute of Electrical and Electronics Engineers (IEEE) 1596.3-1996 standards, is often used in video transmission applications and has become an increasingly popular standard that has been implemented across a constantly growing variety of fields. LVDS is most commonly used to transmit video signals internally from a computer or graphics controller to a display but can also be used to transmit video signals over longer distances or across integrated systems through the use of shielded twisted pair cables. In particular, LVDS technology has gained widespread use in video transmission due to its high speed, low differential swing, and low power consumption. LVDS's high-speed nature and low-voltage swing, however, can potentially cause concern regarding how to properly test displays which rely on it for their video signal inputs. This paper discusses low-cost test strategies for testing LCD displays by generating and transmitting LVDS test signals with a programmable microcontroller or field-programmable gate array (FPGA). Rather than using an expensive and complicated graphics controller to generate LVDS test signals, modern lowcost microcontrollers and FPGAs can be programmed to emulate a graphics controller and properly stimulate an LCD screen to test its full range of colors. In addition to the generation of LVDS video, this paper also addresses the unique concerns associated with LVDS's inherently high-speed and low differential swing, both of which require that special precautions be taken during signal transmission in order to ensure signal integrity. By combining a programmable module with a simple LVDS or FPDLink transmitter, and by taking steps to properly transmit an LVDS signal to an LCD unit, a test designer can use the topics presented in this paper to easily implement a low-cost and smallfootprint LCD test generator into a larger test environment. C1 [Tagliente, Daniel A.] US Army, Automated Test Syst Div, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Tagliente, DA (reprint author), US Army, Automated Test Syst Div, ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4673-0699-7; 978-1-4673-0700-0 J9 IEEE AUTOTESTCON PY 2012 BP 49 EP 53 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BG9AS UT WOS:000392928300010 ER PT S AU Moore, TJ Drost, RJ Basu, P Ramanathan, R Swami, A AF Moore, T. J. Drost, R. J. Basu, P. Ramanathan, R. Swami, A. GP IEEE TI Analyzing Collaboration Networks Using Simplicial Complexes: A Case Study SO 2012 IEEE CONFERENCE ON COMPUTER COMMUNICATIONS WORKSHOPS (INFOCOM WKSHPS) SE IEEE Conference on Computer Communications Workshops LA English DT Proceedings Paper CT IEEE Conference on Computer Communications (INFOCOM) CY MAR 25-30, 2012 CL Orlando, FL SP IEEE AB Collaboration social networks are traditionally modeled using graphs that capture pairwise relationships but have ambiguity between group collaborations and multiple pairwise collaborations. We present a new approach to analyzing collaboration networks using simplicial complexes to represent the co-authorship collaborations. We formally define several key novel metrics: 1) higher dimensional analogs of vertex degree (e.g., simplex and facet degrees), 2) homology, and 3) minimal non-faces; and discuss their interpretation as it relates to co-authorship. We use these metrics in a study of an Army Research Lab dataset that includes the publications of the Communications & Networks Collaborative Technology Alliance. In particular, our study reveals many properties of large networks mirrored by this single-program publication dataset: the distinction of certain simplex degrees from vertex degrees, a power law characteristic in facet degrees, and some properties of topological "holes" and minimal non-faces. C1 [Moore, T. J.; Drost, R. J.; Swami, A.] US Army Res Lab, Salt Lake City, UT USA. RP Moore, TJ (reprint author), US Army Res Lab, Salt Lake City, UT USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2159-4228 BN 978-1-4673-1016-1 J9 IEEE CONF COMPUT PY 2012 BP 238 EP 243 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BB7LY UT WOS:000345737800043 ER PT J AU Manning, TG Leone, J Zebregs, M Ramlal, DR van Driel, CA AF Manning, Thelma G. Leone, Joseph Zebregs, Martijn Ramlal, Dinesh R. van Driel, Chris A. BE Wickert, M Salk, M TI DEFINITION OF A JA2 EQUIVALENT PROPELLANT TO BE PRODUCED BY CONTINUOUS SOLVENT-LESS EXTRUSION SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB The aim of this work is to demonstrate the manufacturing of a propellant by solvent-less continuous twin screw extrusion processing while maintaining gun performance characteristics of conventional JA-2 propellant. This is elucidated by explicitly researching the relationship between interior ballistic properties of the gun propellant and utilizing continuous manufacturing process using modeling and simulation codes. Processing conditions were established and the propellant was manufactured accordingly. The extruded propellant has the desired properties which resulted in a comparable gun performance as the conventional JA-2 propellant. C1 [Manning, Thelma G.; Leone, Joseph] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Manning, TG (reprint author), US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 6 TC 0 Z9 0 U1 1 U2 1 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 22 EP 25 PG 4 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000003 ER PT J AU Bhagwandin, V Sahu, J AF Bhagwandin, V. Sahu, J. BE Wickert, M Salk, M TI NUMERICAL PREDICTION OF DYNAMIC STABILITY DERIVATIVES FOR FINNED PROJECTILES SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB Reynolds-Averaged Navier Stokes computational fluid dynamics and linear flight mechanics theory were used to compute the pitch damping, roll damping and Magnus force and moment dynamic stability derivatives for a generic fin-stabilized missile using two numerical methods, namely, the transient planar pitching and the transient axial rolling methods. Numerical results were compared to archival wind tunnel data for a supersonic flight condition at angles of attack up to 90 degrees. Excellent results were obtained up to mid-range angles of attack. At very high angles of attack the comparisons were fair. The impact of various aerodynamic and numerical modeling parameters was also investigated. C1 [Bhagwandin, V.; Sahu, J.] US Army Res Lab, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. RP Bhagwandin, V (reprint author), US Army Res Lab, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA. NR 21 TC 0 Z9 0 U1 1 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 186 EP 197 PG 12 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000023 ER PT J AU Ilg, M AF Ilg, M. BE Wickert, M Salk, M TI EXTRACTING PROJECTILE FLIGHT DYNAMICS USING AN EMBEDDED GPS RECEIVER SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc ID PREDICTION AB An overwhelming challenge facing the Army as it transitions from conventional ammunition to systems capable of highly precise delivery, is cost, driven by complexity. To meet increasingly demanding precision requirements the complexity of the solutions can grow exponentially. This tremendous growth in system complexity was accompanied by dramatically increasing demands on our modeling & simulation environments (M&S), without which the Army would be unable to predict performance and ultimately impact on the battle-field. The escalation of these problems quickly exceeded the ability of our traditional M&S tools and required a new and truly multi-discipline approach. To address these challenges a Model Based Design (MBD) approach has been utilized to maintain a development environment that adapts to the ever changing physical aspects of the system. This model based approach is applied to the accurate modeling of a GPS receiver and the effect of mortar dynamics on its performance. By utilizing the MBD methods and using a commercial off the shelf (COTS) receiver, engineers can quickly identify the technology gaps and aerodynamic uncertainties through flight experiments without having to have a completed electronics design. The work highlights the analysis and comparison of computer simulation, hardware in the loop evaluations, and flight experiments from an 81mm guided mortar. C1 RDRL WML F, Army Res Lab, Aberdeen Proving Ground, MD 21002 USA. RP Ilg, M (reprint author), RDRL WML F, Army Res Lab, Aberdeen Proving Ground, MD 21002 USA. NR 27 TC 0 Z9 0 U1 0 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 321 EP 332 PG 12 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000037 ER PT J AU Carson, RA Sahni, O AF Carson, R. A. Sahni, O. BE Wickert, M Salk, M TI PLUME-IN-PLANE EXTERIOR BLAST ATTENUATION SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB The purpose of the study was to develop a novel means to reduce blast overpressure (BOP) to the rear of the muzzle of a cannon system. Reduction in BOP, and thus peak overpressure (POP), leads to increase in number of allowed rounds that can be fired over a given period of time, which in turn makes the cannon system more lethal. A novel plume-in-plume technology was investigated using numerical simulations, where the propellant gas was allowed to bleed, in front of the projectile into the precursor region (while the projectile is still in bore), through the addition of flow channels in the mortar tube. The focus of this work is on a large caliber cannon at 1422 mils elevation. A hybrid finite element/volume code (ALE3D) was used to predict the blast overpressure for configurations with and without flow channels. It was found that bleeding of propellant gas in the precursor region changes the properties of the fluid surrounding the muzzle region that reduces the primary blast wave intensity locally in front of the muzzle and acts as a virtual muzzle extender. This concept attenuates blast overpressure in rearward regions to the muzzle with a marginal decrease in projectile velocity (about 3%). Over 30% reduction was achieved in POP at a certain crew location (located on 150 degrees rearward line at a distance of 1m from muzzle and 1.2m above ground). C1 [Carson, R. A.] US Army, ARDEC Benet Labs, 1 Buffington St,Bldg 40, Watervliet, NY 12189 USA. [Sahni, O.] Mil Tech Acad, Inst Chem, PL-00908 Warsaw, Poland. RP Carson, RA (reprint author), US Army, ARDEC Benet Labs, 1 Buffington St,Bldg 40, Watervliet, NY 12189 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 359 EP 371 PG 13 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000040 ER PT J AU Eichhorst, C AF Eichhorst, Charles BE Wickert, M Salk, M TI DEVELOPMENT OF A MULTI-SHOT LAUNCH DYNAMICS MODEL SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB Many gun systems are designed to operate in a rapid automatic or burst firing mode to achieve their maximum lethality potential. The accuracy of the weapon is reduced when operated in these multi-shot firing modes. Consequently, there is a clear need to develop methods to improve the accuracy under these conditions, and one tool that can be used in this process is finite element modeling. While launch dynamics modeling using finite element codes is well-established for a single shot, new techniques are needed to extend these capabilities to multi-shot analyses. This paper describes the method developed to achieve this capability and its application in the study of a medium caliber gun system. C1 US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Eichhorst, C (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 8 TC 0 Z9 0 U1 0 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 372 EP 381 PG 10 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000041 ER PT J AU Minnicino, MA AF Minnicino, M. A. BE Wickert, M Salk, M TI STRUCTURAL DYNAMICS OF DESPUN KINETIC ENERGY PROJECTILES LAUNCHED WITH COMPOSITE SABOTS SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB This paper details the finite element (FE) stress analysis of a conceptual 105-mm kinetic energy (KE) projectile launched with a composite sabot that is subjected to both axial and torsion loadings. The dynamic FE simulation uses input from IBHVG2 and Bandslip to predict the base pressure history and the spin history, respectively. The FE results indicate that the projectile spin history during gun launch has a significant effect on the sabot-penetrator interface shear tractions and consequently, the sabot structural integrity. C1 US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Minnicino, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 7 TC 0 Z9 0 U1 0 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 428 EP 439 PG 12 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000047 ER PT J AU Piehler, T Hummer, C Benjamin, R Summers, E McNesby, K Boyle, V AF Piehler, Thuvan Hummer, Charles Benjamin, Richard Summers, Eugene McNesby, Kevin Boyle, Vincent BE Wickert, M Salk, M TI PRELIMINARY STUDY OF COUPLING ELECTRICAL ENERGY TO DETONATION REACTION ZONE OF PRIMASHEET-1000 EXPLOSIVE SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB It is anticipated that the introduction of high currents will increase the energy content of the conduction gases in the vicinity of the detonation front and lead to an increase in detonation velocity through ohmic heating. The approach is to transfer the stored electrical energy from a 5.5 kV, 0.010 F, 200 kJ capacitor bank into the conductive zone behind the detonation front of Primasheet-1000 explosive reaction. Upon initiation of the explosive, an explosive switch allows the energy stored in the pulsed power assembly to be transferred through the copper plates (separated by either a 0.1, 0.2, or 0.3 cm thick layer of explosive), and into the conducting reaction zone of the detonation front. There was an increase of similar to 4% in the detonation velocity observed in a 0.1 cm thick layer of and similar to 2.6 % detonation velocity enhancement observed in a 0.2 cm thick explosive layer. No detonation velocity enhancement was observed in 0.3cm thick layer of explosive. C1 [Piehler, Thuvan; Hummer, Charles; Benjamin, Richard; Summers, Eugene; McNesby, Kevin] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Boyle, Vincent] Dynam Inc, Aberdeen Proving Ground, MD 21005 USA. RP Piehler, T (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. FU The U.S. Army Research Laboratory (ARL); Weapons and Materials Research Directorate; Protection Division, Applied Physics Branch; Energetic Technology Branch FX The U.S. Army Research Laboratory (ARL), Weapons and Materials Research Directorate, Protection Division, Applied Physics Branch, and Energetic Technology Branch, funded this effort through the Electromagnetic Coupling with Explosive Program. Deborah Pilarski, William Sickles, Ray Sparks, and Ronnie Thompson assisted in the experiments. Scott Crespi, Ensign-Bickford Aerospace & Defense Company, provided Primasheet -1000 explosive for testing. Dr. Eric Bukowski provided critical review of the technical report. NR 2 TC 0 Z9 0 U1 0 U2 4 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 714 EP 724 PG 11 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000075 ER PT J AU Baker, EL Poulos, WJ DeFisher, SE Madsen, TM Pincay, JM Wilson, AD Fuchs, BE Daniels, AS AF Baker, E. L. Poulos, W. J. DeFisher, S. E. Madsen, T. M. Pincay, J. M. Wilson, A. D. Fuchs, B. E. Daniels, A. S. BE Wickert, M Salk, M TI WATER AS A LINEAR SHAPPED CHARGE LINER MATERIAL SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB This paper reports on the use of water as a linear shaped charge liner material. A large variety of materials have been proposed and used as shaped charge liners. Normally, liner materials are solid materials. The use of water in a linear shaped charge (LSC) has several potential benefits. If water is used both for a liner material and tamping, then a device can be developed to produce little or no fragmentation. Additionally, if the water is added to the LSC just before use, than a relatively lightweight LSC hardware can be produced. The water lined and tamped LSC has been named a hydrodynamic linear shaped charge (HLSC). For this study, advanced arbitrary Langrangian-Eulerian (ALE) high rate continuum modeling was used to investigate design concepts and develop final optimized HLSC designs. The demonstrated HLSCs use standard high explosive sheet material (deta-sheet) and are designed to be quickly assembled using extremely lightweight parts. Plastic prototype hardware was quickly produced using modern three dimensional printing technology. Initial concept demonstration testing of the new HLSC technology was performed using high speed photography for jet characterization. Aluminum and steel plates were used to investigate the HLSC cutting capability. Subsequent testing was performed using automobiles as targets. Small scale devices easily cut open the doors, providing access. Large scale HLSC technology completely cut an automobile into two halves. C1 [Baker, E. L.; Poulos, W. J.; DeFisher, S. E.; Madsen, T. M.; Pincay, J. M.; Wilson, A. D.; Fuchs, B. E.; Daniels, A. S.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Baker, EL (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 860 EP 864 PG 5 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000091 ER PT J AU Al-Shehab, N Baker, EL Madsen, T Pfau, D Fuchs, BE Hunter, D AF Al-Shehab, N. Baker, E. L. Madsen, T. Pfau, D. Fuchs, B. E. Hunter, D. BE Wickert, M Salk, M TI THE EFFECT OF SLOW HEATING RATES ON THE COOK-OFF RESPONSE OF HIGH EXPLOSIVE MUNITIONS SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB Recently, the U.S. DoD has standardized with NATO to a 3.3 degrees C/hour (6 degrees F/hr) test, now required on most U.S. Army programs. Joint IM Standards and Passing Criteria were directed to be implemented by the Vice Chairman of the Joint Chiefs of Staff under JROCM 235-06 dated 6 Nov 2006. The U.S. Army has traditionally performed slow cook-off (SCO) testing at a heating rate of 27.8 degrees C/hour (50 degrees F/hr). It is fairly broadly accepted that the SCO test is meant to simulate fire in an adjacent magazine, storage depot or vehicle. Recent guidance from the U.S. Navy recommends not designing to only pass the SCO requirement of 3.3 degrees C/hr, but to also address SCO using rates of 40 degrees F/hr - 60 degrees F/hr. For these reasons, the U.S. Army has recently generated considerable data on munitions that provides a comparison 3.3 degrees C/hr SCO test results to 27.8 degrees C/hr SCO results. The results strongly indicate that mitigation strategies successful for 27.8 degrees C/hr result in violent SCO responses at 3.3 degrees C/hr. This paper presents the test results of a variety of munitions showing this trend. Associated thermal mechanical kinetics continuum modeling clearly indicates that the high explosive billet ignites near the surface at a 27.8 degrees C/hr SCO heating rate, whereas at a 3.3 degrees C/hr SCO rate the ignition occurs near the center of the explosive billet thermal mass. Unfortunately, this increase in violence has been observed for munitions using both solid explosives (pressed and cast cure), as well as for munitions using melt pour explosive formulations. As a result, different strategies are required in order to achieve mitigation at a range of heating rates. Additionally, assessments of realistic heating rates and lower bound heating rate estimates for a given munition system could provide important information in order to provide practical real improvements of Insensitive Munitions response. C1 [Al-Shehab, N.; Baker, E. L.; Madsen, T.; Pfau, D.; Fuchs, B. E.] US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. [Hunter, D.] Gen Dynam OTS, Niceville, FL 32578 USA. RP Al-Shehab, N (reprint author), US Army ARDEC, Picatinny Arsenal, NJ 07806 USA. NR 8 TC 0 Z9 0 U1 1 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 865 EP 871 PG 7 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000092 ER PT J AU Katulka, G Condon, J Hamaoui, M AF Katulka, G. Condon, J. Hamaoui, M. BE Wickert, M Salk, M TI ELECTROMAGNETIC RADIATION CHARACTERISTICS OF DETONATING EXPLOSIVE MATERIALS SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc AB Electromagnetic radiation from samples of explosive materials has been characterized experimentally, throughout the detonation process, with a high-speed, wideband radio-frequency (RF) data acquisition system. Samples of material, including PBXN5 and C4 having masses that ranged from 2g to as much as 500g, were experimentally characterized during the explosive event, beginning from the point just prior to ignition through cessation of detonation. Explosive samples were measured both in free space as well as buried in soil. The measured results were analyzed with Fast Fourier Transform and Wavelet Transform signal processing techniques, to determine the electric-field frequency spectral characteristics of the explosives as the detonation progressed in time. The experimental data revealed distinct signatures from the main explosive charge, where the observed electric field spectra had significant power extending to as much as 2MHz, for the explosive materials and the boundary conditions which were studied. C1 [Katulka, G.; Condon, J.] US Army Res Lab, Weap & Mat Res Directorate, RDRL WML F, Aberdeen Proving Ground, MD 21005 USA. [Hamaoui, M.] Data Matrix Solut, Aberdeen Proving Ground, MD 21001 USA. RP Katulka, G (reprint author), US Army Res Lab, Weap & Mat Res Directorate, RDRL WML F, Aberdeen Proving Ground, MD 21005 USA. NR 5 TC 0 Z9 0 U1 0 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 1019 EP 1029 PG 11 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000108 ER PT J AU Strassburger, E Hunzinger, M Patel, P McCauley, JW AF Strassburger, E. Hunzinger, M. Patel, P. McCauley, J. W. BE Wickert, M Salk, M TI ANALYSIS OF THE FRAGMENTATION OF AlON AND SPINEL UNDER BALLISTIC IMPACT SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc ID TRANSPARENT ARMOR; FAILURE AB It has been demonstrated that significant weight reductions can be achieved, compared to conventional glass-based armor, when a transparent ceramic is used as the strike face on a glass-polymer laminate. Magnesium aluminate spinel (MgAl2O4) and AlON are promising candidate materials for application as a hard front layer in transparent armor. Comprehensive, systematic investigations of the fragmentation of ceramics have shown that the mode of fragmentation is one of the key parameters influencing the ballistic resistance of ceramics. In the study described here, the fragmentation of AlON and three types of spinel was analyzed. The ceramic specimens of 6 mm thickness were glued to an aluminum backing and impacted with armor piercing (AP) projectiles of caliber 7.62 mm at two different velocities - 850 m/s and 1100 m/s. The application of visualization techniques allowed for the analysis of the dynamics of the fragment formation and interaction with the projectile. A significant difference in the fragment size distributions of bi-modal grain sized spinel and AlON was observed. C1 [Strassburger, E.; Hunzinger, M.] Fraunhofer Inst High Speed Dynam EMI, Christianswuhr 2, D-79400 Kandern, Germany. [Patel, P.] US Army, Res Lab, AMSRD ARl WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Strassburger, E (reprint author), Fraunhofer Inst High Speed Dynam EMI, Christianswuhr 2, D-79400 Kandern, Germany. FU US Army International Technology Center - Atlantic (USAITC-A); Army Research Laboratory FX The work reported here was performed under a contract from the US Army International Technology Center - Atlantic (USAITC-A) and the Army Research Laboratory. The authors wish to thank Mr. Donovan Harris of ARL for the contribution of the fragment SEMs and Mr. Doug Slusark of Rutgers University for the microstructure photographs. NR 9 TC 0 Z9 0 U1 0 U2 3 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 1049 EP 1052 PG 4 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000111 ER PT J AU Talladay, TG Templeton, DW AF Talladay, Timothy G. Templeton, Douglas W. BE Wickert, M Salk, M TI A COMPUTATIONAL COMPARISON OF HIGH STRAIN RATE STRENGTH AND FAILURE MODELS FOR GLASS SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc ID PENETRATION; IMPACT AB Computational studies are performed using the recent Holmquist-Johnson glass model and the earlier Johnson-Holmquist brittle material model. Although the JH-2 model has been adapted to provide reasonably accurate predictions for soda-lime glass, the Holmquist-Johnson model was developed specifically to replicate the behaviors of borosilicate glass. Simulations of rod impact on borosilicate glass using these two models are compared to experiments involving impact of mild steel rods on borosilicate glass at ca. 540 m/s. The material constants were adjusted to attain similar strength and damage responses at this impact velocity. In this manner, some light can be shed on the difference in the mechanisms of these two models. The models are compared and contrasted in penetration time, penetration resistance, dwell, and the evolution of visual damage phenomena. The limitations of both models are discussed and the need for more experimental data to corroborate simulations is apparent. C1 [Talladay, Timothy G.; Templeton, Douglas W.] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Talladay, TG (reprint author), US Army Tank Automot Res Dev & Engn Ctr, 6501 E 11 Mile Rd, Warren, MI 48397 USA. NR 13 TC 0 Z9 0 U1 1 U2 4 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 1630 EP 1638 PG 9 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000171 ER PT J AU Wang, YQ Miao, YY Yen, CF Yu, J Zheng, JQ AF Wang, Youqi Miao, Yuyang Yen, Chian-Fong Yu, Jian Zheng, James Q. BE Wickert, M Salk, M TI NUMERICAL SIMULATIONS TO DETERMINE BALLISTIC STRENGTH OF 2-D WOVEN FABRICS SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc ID MECHANICS AB This paper investigates the ballistic strength of 2-D woven fabrics. A fiber-level micro-mechanics method, the digital element approach, is used to simulate the ballistic penetration process through 2-D woven Kevlar KM-2 fabrics. Two fiber strength models are employed: a deterministic fiber strength model and a statistical fiber strength model. In the deterministic simulation, a single deterministic fiber strength, derived from previous single fiber tests, is assigned to all fiber elements. In the statistical simulation, a Monte Carlo process is used to derive the strength of each digital fiber element following a bimodal Weibull distribution function. Based upon the previous experimental results, the fiber is assumed as linear elastic in the longitudinal direction and elasto-plastic in the transverse direction. A spherical projectile strikes fabrics. Residual velocities and V-50 are derived. Numerical results are compared to experimental results. C1 [Wang, Youqi; Miao, Yuyang] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Yen, Chian-Fong; Yu, Jian] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wang, YQ (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. EM Youqi@ksu.edu FU Army Research Laboratory; Army research office FX The material presented in this article is based on research supported by the Army Research Laboratory, Program Executive Office Soldier and the Army research office. NR 13 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 1680 EP 1691 PG 12 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000176 ER PT J AU Meyer, CS AF Meyer, Christopher S. BE Wickert, M Salk, M TI NUMERICAL SIMULATION OF THE PENETRATION AND PERFORATION OF ADOBE BUILDING MATERIALS SO 27TH INTERNATIONAL SYMPOSIUM ON BALLISTICS, VOLS. 1 AND 2 LA English DT Proceedings Paper CT 27th International Symposium on Ballistics (ISB) CY APR 22-26, 2013 CL Freiburg, GERMANY SP Fraunhofer Inst High Speed Dynam, Ernst Mach Inst, Natl Def Ind Assoc, Int Ballist Soc ID 6061-T6511 ALUMINUM TARGETS; NOSE STEEL PROJECTILES; STRIKING VELOCITIES; 3.0 KM/S AB The work described in this paper uses the Holmquist-Johnson-Cook equation of state and constitutive model for concrete and appropriate material parameters derived from mechanical test data to perform numerical simulations of penetration and perforation of adobe building material. Experimental results from the literature are modeled, and two-dimensional numerical simulations are carried out using the CTH Eulerian shock physics code. Two groups of simulations were performed in accordance with the experimental results. The first group is tungsten rod penetrators, with impact velocities ranging from 340 to 820 m/s, perforating adobe targets with thicknesses ranging from 71 to 497 mm, and comparison of the residual velocities predicted by the numerical simulations with the available experimental results. The second group is steel spheres, with impact velocities ranging from 500 to 3230 m/s, penetrating into adobe targets of semi-infinite thickness, and comparison of the depths of penetration predicted by the numerical simulations with the available experimental results. The technique described in this paper for modeling and simulation of adobe penetration and perforation is able to adequately predict the residual velocities and depths of penetration for the conditions modeled. C1 US Army, Res Lab, RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. RP Meyer, CS (reprint author), US Army, Res Lab, RDRL WML H, Aberdeen Proving Ground, MD 21005 USA. NR 22 TC 0 Z9 0 U1 0 U2 2 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-106-5 PY 2012 BP 1711 EP 1722 PG 12 WC Mechanics SC Mechanics GA BJO71 UT WOS:000329410000179 ER PT S AU Feng, Z Pelechrinis, K Krishnamurthy, S Swami, A Wu, F Singh, MP AF Feng, Zi Pelechrinis, Konstantinos Krishnamurthy, Srikanth Swami, Ananthram Wu, Felix Singh, Munindar P. GP IEEE TI Collaborative Assessment of Functional Reliability in Wireless Networks SO 9TH IEEE INTERNATIONAL CONFERENCE ON MOBILE AD-HOC AND SENSOR SYSTEMS (MASS 2012) SE IEEE International Conference on Mobile Ad-hoc and Sensor Systems LA English DT Proceedings Paper CT 9th IEEE International Conference on Mobile Ad-Hoc and Sensor Systems (MASS) CY OCT 08-11, 2012 CL Las Vegas, NV SP IEEE, IEEE Comp Soc AB Nodes that are part of a multihop wireless network, typically deployed in mission critical settings, are expected to perform specific functions. Establishing a notion of reliability of the nodes with respect to each function (referred to as functional reliability or FR) is essential for efficient operations and management of the network. This is typically assessed based on evidence collected by nodes with regards to other nodes in the network. However, such evidence is often affected by factors such as channel induced effects and interference. In multihop contexts, unreliable intermediary relays may also influence evidence. We design a framework for collaborative assessment of the FR of nodes, with respect to different types of functions; our framework accounts for the above factors that influence evidence collection. Each node (say Chloe) in the network derives the FR of other nodes (say Jack) based on two types of evidence: (i) direct evidence, based on her direct transactions with each such node and (ii) indirect evidence, based on feedback received regarding Jack from others. Our framework is generic and is applicable in a variety of contexts. We also design a module that drastically reduces the overhead incurred in the propagation of indirect evidence at the expense of slightly increased uncertainty in the assessed FR values. We implement our framework on an indoor/outdoor wireless testbed. We show that with our framework, each node is able to determine the FR for every other node in the network with high accuracy. Our indirect evidence propagation module decreases the overhead by 37% compared to a simple flooding based evidence propagation, while the accuracy of the FR computations is decreased only by 8%. Finally, we examine the effect of different routing protocols on the accuracy of the assessed values. C1 [Feng, Zi; Krishnamurthy, Srikanth] UC Riverside, Riverside, CA 92521 USA. [Pelechrinis, Konstantinos] Univ Pittsburgh, Pittsburgh, PA USA. [Swami, Ananthram] US Army, Res Labs, Adelphi, MD USA. [Wu, Felix] Univ Calif Davis, Davis, CA USA. [Singh, Munindar P.] North Carolina State Univ, Raleigh, NC 27695 USA. RP Feng, Z (reprint author), UC Riverside, Riverside, CA 92521 USA. EM zfeng@cs.ucr.edu; kpele@pitt.edu; krish@cs.ucr.edu; aswami@arl.army.mil; wu@cs.ucdavis.edu; singh@ncsu.edu OI Singh, Munindar/0000-0003-3599-3893 FU Army Research Laboratory [W911NF- 09- 2- 0053]; University of Pittsburgh Central Research Development Fund FX Research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF- 09- 2- 0053 and partially supported by the University of Pittsburgh Central Research Development Fund. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U. S. Government. The U. S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation here on. NR 15 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2155-6806 BN 978-1-4673-2433-5; 978-1-4673-2432-8 J9 IEEE INT CONF MOB PY 2012 BP 425 EP 433 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA BEZ33 UT WOS:000318874900048 ER PT B AU Sottilare, R Hart, J AF Sottilare, Robert Hart, John BE Duffy, VG TI Cognitive and Affective Modeling in Intelligent Virtual Humans for Training and Tutoring Applications SO ADVANCES IN APPLIED HUMAN MODELING AND SIMULATION SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE virtual humans; training; computer-based tutoring AB This chapter reviews current and emerging trends in cognitive and affective (e.g., emotions, motivational) modeling within virtual humans and their application to training and tutoring domains for individuals and small groups. Virtual humans have become commonplace in computer games and other digital entertainment applications, but their use for training and one-to-one tutoring applications is evolving and remains primarily focused on well-defined training/tutoring domains (e.g., procedural tasks and rule-based domains including mathematics and physics). In order to support viable self-regulated learning environments, future training and tutoring systems will require virtual humans with enhanced cognitive and affective capabilities that are adaptive, engaging and motivating in ill-defined domains. C1 [Sottilare, Robert; Hart, John] US Army Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. RP Sottilare, R (reprint author), US Army Res Lab, Human Res & Engn Directorate, Orlando, FL 32826 USA. EM robert.sottilare@us.army.mil; john.hartiii@us.army.mil NR 23 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7032-7; 978-1-4398-7031-0 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2012 BP 113 EP 122 PG 10 WC Ergonomics SC Engineering GA BC2WC UT WOS:000351388700012 ER PT B AU Li, P Corner, B Paquette, S AF Li, Peng Corner, Brian Paquette, Steven BE Duffy, VG TI Shape Description of the Human Body Based on Discrete Cosine Transform SO ADVANCES IN APPLIED HUMAN MODELING AND SIMULATION SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE Discrete Cosine Transform; Shape description; Human body AB This paper investigates the shape description of the human body based on the discrete cosine transform (DCT). The DCT is able to compress a dense three-dimensional (3D) surface into a small vector but preserve shape information truthfully. In order to apply the DCT to a 3D body scan, we segment each scan into six regions and represent them in a cylindrical coordinate system. In this paper we discuss this method and its application to torso shape retrieval. C1 [Li, Peng; Corner, Brian; Paquette, Steven] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. RP Li, P (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7032-7; 978-1-4398-7031-0 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2012 BP 169 EP 178 PG 10 WC Ergonomics SC Engineering GA BC2WC UT WOS:000351388700017 ER PT B AU Durlach, PJ Spain, RD AF Durlach, Paula J. Spain, Randall D. BE Duffy, VG TI Framework for Instructional Technology SO ADVANCES IN APPLIED HUMAN MODELING AND SIMULATION SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE adaptation; remediation; feedback; interaction; learning; sequencing AB There are various ways in which an adaptive learning environment could adapt-both in terms of the student data used to make instructional decisions and in the types of instructional decisions that are made. This paper will describe a framework for instructional technology (FIT), aimed at delineating four types of instructional decisions that a technology-based learning environment can make: corrective feedback, support, micro-sequencing, and macro-sequencing. Corrective feedback addresses ways that explicit feedback concerning errors could be given. Support addresses how the technology supports the student within a task with hints or prompts. Micro-sequencing addresses how a technology-based instructional environment determines what content or task to present next within a module. Macro-sequencing addresses how a technology-based instructional environment determines what module to present next. For each decision, FIT lays out a continuum of complexity, which roughly maps to levels of adaptation, and the corresponding sophistication of the student model required to support those decisions. Within any particular instructional system, the level can be different for corrective feedback, macro-sequencing, micro-sequencing, and support decisions. C1 [Durlach, Paula J.; Spain, Randall D.] US Army Res Inst, Orlando, FL 32826 USA. RP Durlach, PJ (reprint author), US Army Res Inst, Orlando, FL 32826 USA. EM Paula.Durlach@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7032-7; 978-1-4398-7031-0 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2012 BP 222 EP 231 PG 10 WC Ergonomics SC Engineering GA BC2WC UT WOS:000351388700022 ER PT S AU Filippov, AA Sergueev, KV He, YX Nikolich, MP AF Filippov, Andrey A. Sergueev, Kirill V. He, Yunxiu Nikolich, Mikeljon P. BE DeAlmeida, AMP Leal, NC TI Bacteriophages Capable of Lysing Yersinia pestis and Yersinia pseudotuberculosis: Efficiency of Plating Tests and Identification of Receptors in Escherichia coli K-12 SO ADVANCES IN YERSINIA RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Article; Proceedings Paper CT 10th International Symposium on Yersinia CY OCT 23-27, 2010 CL Recife, BRAZIL ID GENOME SEQUENCE; PASTEURELLA-PSEUDOTUBERCULOSIS; PHAGE THERAPY; PLAGUE; RESISTANCE; STRAINS; PROTEIN; GENES; HISTORY C1 [Filippov, Andrey A.; Sergueev, Kirill V.; He, Yunxiu; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Filippov, AA (reprint author), Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave,Room 3A03, Silver Spring, MD USA. EM andrey.filippov@amedd.army.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office, Medical ST Division FX We wish to thank Dr. Richard Calendar for critical reading of the manuscript and valuable comments, Drs Martin E Schriefer, Ian J Molineux, and Bakyt B Atshabar for providing bacteriophages. This research was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office, Medical S&T Division. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army or the Department of Defense. NR 54 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4614-3560-0; 978-1-4614-3561-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 954 BP 123 EP 134 DI 10.1007/978-1-4614-3561-7_16 PG 12 WC Biochemistry & Molecular Biology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Microbiology GA BA2DD UT WOS:000333327900017 PM 22782755 ER PT S AU Sergueev, KV Nikolich, MP Filippov, AA AF Sergueev, Kirill V. Nikolich, Mikeljon P. Filippov, Andrey A. BE DeAlmeida, AMP Leal, NC TI Field and Clinical Applications of Advanced Bacteriophage-Based Detection of Yersinia pestis SO ADVANCES IN YERSINIA RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Article; Proceedings Paper CT 10th International Symposium on Yersinia CY OCT 23-27, 2010 CL Recife, BRAZIL ID REAL-TIME PCR; CHAIN-REACTION ASSAY; PLAGUE; HISTORY C1 [Sergueev, Kirill V.; Nikolich, Mikeljon P.; Filippov, Andrey A.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Sergueev, KV (reprint author), Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kirill.sergueev@amedd.army.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office, Medical ST Division FX This research was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office, Medical S&T Division. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army or the Department of Defense. NR 26 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4614-3560-0; 978-1-4614-3561-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 954 BP 135 EP 141 DI 10.1007/978-1-4614-3561-7_17 PG 7 WC Biochemistry & Molecular Biology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Microbiology GA BA2DD UT WOS:000333327900018 PM 22782756 ER PT S AU Mou, S Cote, CK Worsham, PL AF Mou, Sherry Cote, Christopher K. Worsham, Patricia L. BE DeAlmeida, AMP Leal, NC TI Cytotoxic Necrotizing Factor Is an Effective Immunogen in a Yersinia pseudotuberculosis Aerosol Mouse Model SO ADVANCES IN YERSINIA RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Article; Proceedings Paper CT 10th International Symposium on Yersinia CY OCT 23-27, 2010 CL Recife, BRAZIL ID BACTERIAL TOXINS C1 [Mou, Sherry; Cote, Christopher K.; Worsham, Patricia L.] US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Worsham, PL (reprint author), US Army Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM patricia.worsham@us.army.mil FU Defense Threat Reduction Agency JSTO-CBD [1.1A0020_07_RD_B] FX This research was sponsored by the Defense Threat Reduction Agency JSTO-CBD project number 1.1A0020_07_RD_B. The views expressed in this publication are those of the author(s) and do not reflect the official policy of the Department of the Army, Department of Defense or the US Government. NR 10 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4614-3560-0; 978-1-4614-3561-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 954 BP 179 EP 181 DI 10.1007/978-1-4614-3561-7_23 PG 3 WC Biochemistry & Molecular Biology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Microbiology GA BA2DD UT WOS:000333327900024 PM 22782762 ER PT S AU Filippov, AA Sergueev, KV He, YX Huang, XZ Gnade, BT Mueller, AJ Fernandez-Prada, CM Nikolich, MP AF Filippov, Andrey A. Sergueev, Kirill V. He, Yunxiu Huang, Xiao-Zhe Gnade, Bryan T. Mueller, Allen J. Fernandez-Prada, Carmen M. Nikolich, Mikeljon P. BE DeAlmeida, AMP Leal, NC TI Bacteriophage Therapy of Experimental Bubonic Plague in Mice SO ADVANCES IN YERSINIA RESEARCH SE Advances in Experimental Medicine and Biology LA English DT Article; Proceedings Paper CT 10th International Symposium on Yersinia CY OCT 23-27, 2010 CL Recife, BRAZIL ID YERSINIA-PESTIS; PHAGE THERAPY; PSEUDOMONAS-AERUGINOSA; PNEUMONIC PLAGUE; STAPHYLOCOCCUS-AUREUS; TRANSFERABLE PLASMID; CLINICAL ISOLATE; CYTO-TOXICITY; RESISTANCE; INFECTIONS C1 [Filippov, Andrey A.; Sergueev, Kirill V.; He, Yunxiu; Huang, Xiao-Zhe; Gnade, Bryan T.; Mueller, Allen J.; Fernandez-Prada, Carmen M.; Nikolich, Mikeljon P.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Filippov, AA (reprint author), Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. EM andrey.filippov@amedd.army.mil FU Defense Threat Reduction Agency; Joint Science and Technology Office; Medical ST Division FX This work was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office, Medical S&T Division. We wish to thank Ms. Dipali J. Patel and Mrs. Stacy M. Banko-Crawford for excellent technical assistance. Dr. Martin E. Schriefer (Bacterial Diseases Branch, Division of Vector-Borne Infectious Disease, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Ft. Collins, CO) is gratefully acknowledged for providing bacteriophage j A1122. The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army or the Department of Defense. NR 57 TC 5 Z9 5 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 0065-2598 BN 978-1-4614-3560-0; 978-1-4614-3561-7 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2012 VL 954 BP 337 EP 348 PG 12 WC Biochemistry & Molecular Biology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Microbiology GA BA2DD UT WOS:000333327900042 PM 22782780 ER PT S AU Miyahira, SD Folen, RA Hoffman, HG Garcia-Palacios, A Spira, JL Kawasaki, M AF Miyahira, Sarah D. Folen, Raymond A. Hoffman, Hunter G. Garcia-Palacios, Azucena Spira, James L. Kawasaki, Michelle BE Wiederhold, BK Riva, G TI The Effectiveness of VR Exposure Therapy for PTSD in Returning Warfighters SO ANNUAL REVIEW OF CYBERTHERAPY AND TELEMEDICINE 2012: ADVANCED TECHNOLOGIES IN THE BEHAVIORAL, SOCIAL AND NEUROSCIENCES SE Studies in Health Technology and Informatics LA English DT Article; Book Chapter DE Virtual reality; PTSD; exposure therapy; combat AB In the decade following the attack on the World Trade Center, over 2.3 million American military personnel were deployed to Iraq and Afghanistan. Lengthy tours of duty and multiple re-deployments were characteristic of these operations. Research findings demonstrate that prolonged exposure to combat increases the risk of developing posttraumatic stress disorder (PTSD). The current study was a randomized controlled clinical trial designed to assess the effectiveness of a novel intervention to treat combat-related PTSD in returning Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) warfighters. A cognitive behavior treatment approach augmented with virtual reality exposure therapy (VRE) was developed, and administered for 10 treatment sessions over 5 weeks. Comparisons with a control group receiving minimal attention (MA) for 5 weeks revealed that the VRE group had significant reductions in the avoidance/numbing symptoms on the Clinician Administered PTSD Scale (CAPS). The VRE group also had significant reductions in guilt at post-treatment compared to the control group. C1 [Miyahira, Sarah D.] US Army Pacific Reg Med Command, Honolulu, HI USA. [Folen, Raymond A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Hoffman, Hunter G.] Univ Washington, Seattle, WA 98195 USA. [Garcia-Palacios, Azucena] Univ Jaume 1, Castellon de La Plana, Spain. [Spira, James L.; Kawasaki, Michelle] VAPIHCS, VA Natl Ctr PTSD, Honolulu, HI USA. RP Miyahira, SD (reprint author), Pacific Reg Med Command, 1 Jarrett White Rd,9B-116B, Honolulu, HI 96859 USA. EM sarah.d.miyahira@us.army.mil RI Garcia-Palacios, Azucena/C-9854-2011 OI Garcia-Palacios, Azucena/0000-0001-9250-8714 NR 5 TC 4 Z9 4 U1 1 U2 11 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0926-9630 BN 978-1-61499-121-2 J9 STUD HEALTH TECHNOL PY 2012 VL 181 BP 128 EP 132 DI 10.3233/978-1-61499-121-2-128 PG 5 WC Computer Science, Cybernetics; Health Care Sciences & Services; Medical Informatics SC Computer Science; Health Care Sciences & Services; Medical Informatics GA BA9IV UT WOS:000339449900026 PM 22954842 ER PT B AU Martin, JW AF Martin, James W. BE Swearengen, JR TI History of Biological Agents as Weapons SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID BACTERIOLOGICAL WARFARE; BIOTERRORISM; PERSPECTIVE C1 Walter Reed Army Med Ctr, DiLorenzo Healthcare Clin, Washington, DC 20307 USA. RP Martin, JW (reprint author), Walter Reed Army Med Ctr, DiLorenzo Healthcare Clin, Washington, DC 20307 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 1 EP 13 D2 10.1201/b11523 PG 13 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400002 ER PT B AU Swearengen, JR Anderson, AO AF Swearengen, James R. Anderson, Arthur O. BE Swearengen, JR TI Scientific and Ethical Importance of Animal Models in Biodefense Research SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID US FOOD C1 [Swearengen, James R.] Natl Biodef Anal & Countermeasures Ctr, Ft Detrick, MD 21702 USA. [Anderson, Arthur O.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Swearengen, JR (reprint author), Natl Biodef Anal & Countermeasures Ctr, Ft Detrick, MD 21702 USA. OI Anderson, Arthur/0000-0001-6684-8491 NR 41 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 27 EP 43 D2 10.1201/b11523 PG 17 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400004 ER PT B AU Anderson, JB Tucker, K AF Anderson, Jaime B. Tucker, Kenneth BE Swearengen, JR TI Development and Validation of Animal Models SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID MICE; TOXINS; TOXICITIES; RECEPTORS; HOST; AIDS C1 [Anderson, Jaime B.] US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Tucker, Kenneth] Tauri Grp, Alexandria, VA USA. RP Anderson, JB (reprint author), US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA. NR 37 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 45 EP 64 D2 10.1201/b11523 PG 20 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400005 ER PT B AU Roy, CJ Pitt, MLM AF Roy, Chad J. Pitt, M. Louise M. BE Swearengen, JR TI Infectious Disease Aerobiology Aerosol Challenge Methods SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID ENCEPHALITIS-VIRUS; EXPOSURE SYSTEM; DEPOSITION; PARTICLE; MICE C1 [Roy, Chad J.] Tulane Sch Med, Tulane Natl Primate Res Ctr, Covington, LA 70112 USA. [Pitt, M. Louise M.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Roy, CJ (reprint author), Tulane Sch Med, Tulane Natl Primate Res Ctr, Covington, LA 70112 USA. NR 23 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 65 EP 79 D2 10.1201/b11523 PG 15 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400006 ER PT B AU Leffel, EK Pitt, MLM AF Leffel, Elizabeth K. Pitt, M. Louise M. BE Swearengen, JR TI Characterization of New and Advancement of Existing Animal Models of Bacillus anthracis Infection SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID EXPERIMENTAL INHALATIONAL ANTHRAX; PROTECTIVE ANTIGEN VACCINE; AEROSOL CHALLENGE MODEL; AFRICAN-GREEN MONKEY; IN-VITRO CORRELATE; GUINEA-PIGS; RHESUS MACAQUES; SPORE CHALLENGE; MURINE MODEL; POSTEXPOSURE PROPHYLAXIS C1 [Leffel, Elizabeth K.] PharmAthene Inc, Nonclin Sci, Annapolis, MD 21401 USA. [Pitt, M. Louise M.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Leffel, EK (reprint author), PharmAthene Inc, Nonclin Sci, Annapolis, MD 21401 USA. NR 126 TC 2 Z9 2 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 81 EP 98 D2 10.1201/b11523 PG 18 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400007 ER PT B AU Fritz, DL Waag, DM AF Fritz, David L. Waag, David M. BE Swearengen, JR TI Glanders SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID BURKHOLDERIA-MALLEI GLANDERS; IN-VITRO; BALB/C MICE; SUSCEPTIBILITIES; PSEUDOMALLEI; CEFTAZIDIME; INFECTION; EFFICACY; MOUSE; MODEL C1 [Fritz, David L.; Waag, David M.] US Army, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Fritz, DL (reprint author), US Army, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 65 TC 1 Z9 1 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 99 EP 111 D2 10.1201/b11523 PG 13 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400008 ER PT B AU Adamovicz, JJ Worsham, PL AF Adamovicz, Jeffrey J. Worsham, Patricia L. BE Swearengen, JR TI Plague SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID PRIMARY PNEUMONIC PLAGUE; EXPERIMENTAL YERSINIA-PESTIS; PASTEURELLA-PESTIS; BUBONIC PLAGUE; CYNOMOLGUS MACAQUES; IMMUNE-RESPONSE; GUINEA-PIGS; NONHUMAN-PRIMATES; MURINE MODEL; V-ANTIGEN C1 [Adamovicz, Jeffrey J.] Midwest Res Inst, Frederick, MD 21701 USA. [Worsham, Patricia L.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Adamovicz, JJ (reprint author), Midwest Res Inst, Frederick, MD 21701 USA. NR 177 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 113 EP 145 D2 10.1201/b11523 PG 33 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400009 ER PT B AU Adamovicz, JJ Waag, DM AF Adamovicz, Jeffrey J. Waag, David M. BE Swearengen, JR TI Tularemia SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID LIVE VACCINE STRAIN; FRANCISELLA-TULARENSIS-LVS; VIRULENT TYPE-A; LETHAL INHALATIONAL INFECTION; EXPERIMENTAL MURINE TULAREMIA; MARMOSET CALLITHRIX-JACCHUS; HUMORAL IMMUNE-RESPONSES; PROTECTIVE IMMUNITY; PASTEURELLA-TULARENSIS; INTRACELLULAR BACTERIUM C1 [Adamovicz, Jeffrey J.] Midwest Res Inst, Frederick, MD 21701 USA. [Waag, David M.] US Army, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Adamovicz, JJ (reprint author), Midwest Res Inst, Frederick, MD 21701 USA. NR 159 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 147 EP 177 D2 10.1201/b11523 PG 31 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400010 ER PT B AU Waag, DM Fritz, DL AF Waag, David M. Fritz, David L. BE Swearengen, JR TI Q Fever SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID I COXIELLA-BURNETII; METHANOL RESIDUE VACCINE; INFECTED GUINEA-PIGS; PHASE-I; Q-VAX; PATHOLOGICAL-CHANGES; COMPARATIVE EFFICACY; MACACA-FASCICULARIS; CELLULAR-IMMUNITY; WEST-MIDLANDS C1 [Waag, David M.; Fritz, David L.] US Army, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Waag, DM (reprint author), US Army, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 90 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 179 EP 195 D2 10.1201/b11523 PG 17 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400011 ER PT B AU Purcell, BK Rivard, R AF Purcell, Bret K. Rivard, Robert BE Swearengen, JR TI Brucellosis SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID LABORATORY-ACQUIRED INFECTIONS; REV-I VACCINE; BIOLOGICAL WEAPONS; GENOME SEQUENCE; BLOOD CULTURES; UNITED-STATES; CLINICAL-MANIFESTATIONS; CHILDHOOD BRUCELLOSIS; ABORTUS INFECTION; PURIFIED ANTIGEN C1 [Purcell, Bret K.; Rivard, Robert] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Purcell, BK (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 180 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 197 EP 222 D2 10.1201/b11523 PG 26 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400012 ER PT B AU Pratt, WD Fine, DL Hart, MK Martin, SS Reed, DS AF Pratt, William D. Fine, Donald L. Hart, Mary Kate Martin, Shannon S. Reed, Douglas S. BE Swearengen, JR TI Alphaviruses SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID EQUINE-ENCEPHALITIS-VIRUS; ENVELOPED ANIMAL VIRUSES; CENTRAL-NERVOUS-SYSTEM; ENCEPHALOMYELITIS VIRUS; WESTERN-EQUINE; GUINEA-PIGS; CYNOMOLGUS MACAQUES; MONOCLONAL-ANTIBODIES; VACCINE CANDIDATE; NONHUMAN-PRIMATES C1 [Pratt, William D.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Fine, Donald L.; Hart, Mary Kate; Martin, Shannon S.] Dynport Vaccine Co LLC, Frederick, MD USA. [Reed, Douglas S.] Univ Pittsburg, Ctr Vaccine Res, Pittsburgh, PA USA. RP Pratt, WD (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 121 TC 1 Z9 1 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 223 EP 254 D2 10.1201/b11523 PG 32 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400013 ER PT B AU Greenbaum, SB Anderson, JB Lebeda, FJ AF Greenbaum, Stephen B. Anderson, Jaime B. Lebeda, Frank J. BE Swearengen, JR TI Botulinum Toxins SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID NEUROTOXIN TYPE-A; DIFFERENT MOLECULAR SIZES; RAT NEUROMUSCULAR-JUNCTION; CENTRAL-NERVOUS-SYSTEM; ORAL TOXICITIES; PROGENITOR TOXIN; SMALL-INTESTINE; TETANUS TOXIN; C NEUROTOXIN; B TOXINS C1 [Greenbaum, Stephen B.] BAI Inc, Alexandria, VA 22304 USA. [Anderson, Jaime B.] US Army, Med Res & Mat Command, Ft Detrick, MD USA. [Lebeda, Frank J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Greenbaum, SB (reprint author), BAI Inc, Alexandria, VA 22304 USA. NR 136 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 311 EP 331 D2 10.1201/b11523 PG 21 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400016 ER PT B AU Krakauer, T Stiles, BG AF Krakauer, Teresa Stiles, Bradley G. BE Swearengen, JR TI Staphylococcal and Streptococcal Superantigens In Vitro and In Vivo Assays SO BIODEFENSE RESEARCH METHODOLOGY AND ANIMAL MODELS, 2ND EDITION LA English DT Article; Book Chapter ID TOXIC-SHOCK-SYNDROME; MAJOR HISTOCOMPATIBILITY COMPLEX; MHC CLASS-II; T-CELL-RECEPTOR; AUREUS ENTEROTOXIN-B; TUMOR-NECROSIS-FACTOR; BLOOD MONONUCLEAR-CELLS; HUMAN PERIPHERAL-BLOOD; NF-KAPPA-B; HUMAN-LEUKOCYTE ANTIGEN-DQ8 C1 [Krakauer, Teresa; Stiles, Bradley G.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Krakauer, T (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 290 TC 0 Z9 0 U1 0 U2 2 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3633-0; 978-1-4398-3632-3 PY 2012 BP 357 EP 389 D2 10.1201/b11523 PG 33 WC Immunology; Infectious Diseases; Medicine, Research & Experimental SC Immunology; Infectious Diseases; Research & Experimental Medicine GA BD7FJ UT WOS:000362981400018 ER PT J AU Barajas-Valdes, U Portela-Gauthier, G Gonzalez, RN Velazquez, G Varela-Ortiz, W AF Barajas-Valdes, U. Portela-Gauthier, G. Gonzalez, R. N. Velazquez, G. Varela-Ortiz, W. BE Biondini, F Frangopol, DM TI Towards a load rating methodology for concrete-encased pre-stressed steel girder bridges based on US standards SO BRIDGE MAINTENANCE, SAFETY, MANAGEMENT, RESILIENCE AND SUSTAINABILITY LA English DT Proceedings Paper CT 6th International Conference on Bridge Maintenance, Safety and Management (IABMAS) CY JUL 08-12, 2012 CL Stresa, ITALY SP Int Assoc Bridge Maintenance & Safety, Politecnico Milano AB A very unique type of bridge is in service on a few installations within US Army garrisons. These bridges utilize steel main girders that are pre-stressed and encased in concrete. Beyond these few, no others are known to exist in North America, and likewise no US load rating standards exist for analytical evaluation of their safety. This study is aimed toward the development of an analytical methodology for this purpose by combining AASHTO rating factors recommended for pre-stressed concrete bridges and steel-girder bridges. In this study, load ratings of a 125-ft-long pre-stressed composite (steel beam/concrete encased) bridge are obtained. The variable parameters were bridge condition, steel section loss, and concrete compressive strength. The pre-stressed composite system that was designed with modifications to current AASHTO provisions exhibited favorable rating results, even when affected by steel section loss and concrete strength reductions. The main contribution to the flexural capacity of the pre-stressed composite bridge appears to be attributable to the steel section embedded in the concrete slab. C1 [Barajas-Valdes, U.] Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00682 USA. [Portela-Gauthier, G.] Univ Puerto Rico, Dept Mat Sci & Engn, Mayaguez, PR USA. [Gonzalez, R. N.; Velazquez, G.; Varela-Ortiz, W.] US Army, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS USA. RP Barajas-Valdes, U (reprint author), Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00682 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-415-62124-3 PY 2012 BP 2766 EP 2771 PG 6 WC Engineering, Civil SC Engineering GA BJJ58 UT WOS:000328502804014 ER PT B AU Wilson, I Cox, E Park, KW Sondheimer, RM AF Wilson, Isaiah, III Cox, Edward Park, Kent W. Sondheimer, Rachel M. BE Cimbala, SJ TI Kids These Days: Growing Military Professionalism across Generations SO CIVIL-MILITARY RELATIONS IN PERSPECTIVE: STRATEGY, STRUCTURE AND POLICY LA English DT Article; Book Chapter C1 [Wilson, Isaiah, III; Sondheimer, Rachel M.] US Mil Acad, Dept Social Sci, West Point, PA USA. [Cox, Edward; Park, Kent W.] US Mil Acad, West Point, PA USA. [Park, Kent W.] Stryker Infantry Co, Ft Wainwright, AR USA. RP Wilson, I (reprint author), US Mil Acad, Dept Social Sci, West Point, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-2979-1; 978-1-4094-2978-4 PY 2012 BP 21 EP 30 PG 10 WC History; Political Science SC History; Government & Law GA BA3QC UT WOS:000334608500002 ER PT B AU Blank, SJ AF Blank, Stephen J. BE Cimbala, SJ TI Civil-Military Relations in Contemporary Russia SO CIVIL-MILITARY RELATIONS IN PERSPECTIVE: STRATEGY, STRUCTURE AND POLICY LA English DT Article; Book Chapter C1 US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. RP Blank, SJ (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-2979-1; 978-1-4094-2978-4 PY 2012 BP 53 EP 68 PG 16 WC History; Political Science SC History; Government & Law GA BA3QC UT WOS:000334608500004 ER PT S AU Patev, RC AF Patev, Robert C. BE Makhutov, NA Baecher, GB TI Vulnerability Assessment of Complex Civil Works Systems Using Expert-Opinion Elicitation SO COMPARATIVE ANALYSIS OF TECHNOLOGICAL AND INTELLIGENT TERRORISM IMPACTS ON COMPLEX TECHNICAL SYSTEMS SE Nato Science for Peace and Security Series E-Human and Societal Dynamics LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Comparative Analysis of Technological and Sociological Consequences of Terrorism CY APR 05-07, 2011 CL Moscow, RUSSIA SP NATO DE Vulnerability Assessment; Risk Assessment; Expert Opinion Elicitation; Delphi Method; Words of Estimative Probabilities AB This paper describes a technique that could be utilized to estimate the probabilities and consequences required in vulnerability assessment for terrorist threats of civil works projects. The Expert-Opinion Elicitation (EOE) methodology developed by the U. S. Army Corps of Engineers is presented in detail. The USACE EOE methodology limits the use of words of estimative probabilities to reduce the anchoring bias that is present with qualitative descriptors. A demonstration vulnerability EOE example will as be included to show how the process and opinion data may be properly analyzed. Conclusions are drawn to show the major benefits of using the EOE methodology to estimate probabilities for vulnerability assessment. C1 US Army Corps Engineers, Risk Management Ctr, Concord, MA 01742 USA. RP Patev, RC (reprint author), US Army Corps Engineers, Risk Management Ctr, Concord, MA 01742 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1879-8268 BN 978-1-61499-131-1; 978-1-61499-130-4 J9 NATO SCI PEACE SEC PY 2012 VL 102 BP 120 EP 129 DI 10.3233/978-1-61499-131-1-120 PG 10 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC1WL UT WOS:000350462600012 ER PT S AU Shekhar, S Patel, VM Nasrabadi, NM Chellappa, R AF Shekhar, Sumit Patel, Vishal M. Nasrabadi, Nasser M. Chellappa, Rama BE Fusiello, A Murino, V Cucchiara, R TI Joint Sparsity-Based Robust Multimodal Biometrics Recognition SO COMPUTER VISION - ECCV 2012, PT III SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 12th European Conference on Computer Vision (ECCV) CY OCT 07-13, 2012 CL Florence, ITALY SP Google, Natl Robot Engn Ctr, Adobe, Microsoft Res, Mitsubishi Elect, Mobileye, Nvidia, Point Grey, Technicolor, Toshiba, Toyota, Datalogic, IBM Res, ST, Univ Studi Firenze, Univ Cambridge, Ente Cassa Risparmio Firenze ID LOGISTIC-REGRESSION; ALGORITHMS; SELECTION; LASSO AB Traditional biometric recognition systems rely on a single biometric signature for authentication. While the advantage of using multiple sources of information for establishing the identity has been widely recognized, computational models for multimodal biometrics recognition have only recently received attention. We propose a novel multimodal multivariate sparse representation method for multimodal biometrics recognition, which represents the test data by a sparse linear combination of training data, while constraining the observations from different modalities of the test subject to share their sparse representations. Thus, we simultaneously take into account correlations as well as coupling information between biometric modalities. Furthermore, the model is modified to make it robust to noise and occlusion. The resulting optimization problem is solved using an efficient alternative direction method. Experiments on a challenging public dataset show that our method compares favorably with competing fusion-based methods. C1 [Shekhar, Sumit; Patel, Vishal M.; Chellappa, Rama] Univ Maryland, College Pk, MD 20742 USA. [Nasrabadi, Nasser M.] Army Res Lab, Adelphi, MD USA. RP Shekhar, S (reprint author), Univ Maryland, College Pk, MD 20742 USA. NR 19 TC 3 Z9 3 U1 1 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-33885-4; 978-3-642-33884-7 J9 LECT NOTES COMPUT SC PY 2012 VL 7585 BP 365 EP 374 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Interdisciplinary Applications; Computer Science, Theory & Methods; Robotics SC Computer Science; Robotics GA BE3TK UT WOS:000371261400037 ER PT S AU Nguyen, HV Patel, VM Nasrabadi, NM Chellappa, R AF Nguyen, Hien V. Patel, Vishal M. Nasrabadi, Nasser M. Chellappa, Rama BE Fitzgibbon, A Lazebnik, S Perona, P Sato, Y Schmid, C TI Sparse Embedding: A Framework for Sparsity Promoting Dimensionality Reduction SO COMPUTER VISION - ECCV 2012, PT VI SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 12th European Conference on Computer Vision (ECCV) CY OCT 07-13, 2012 CL Florence, ITALY SP Google, Natl Robot Engn Ctr, Adobe, Microsoft Res, Mitsubishi Elect, Mobileye, Nvidia, Point Grey, Technicolor, Toshiba, Toyota, Datalogic, IBM Res, ST, Univ Studi Firenze, Univ Cambridge, Ente Cassa Risparmio Firenze ID K-SVD; REPRESENTATION; CLASSIFICATION; DICTIONARIES AB We introduce a novel framework, called sparse embedding (SE), for simultaneous dimensionality reduction and dictionary learning. We formulate an optimization problem for learning a transformation from the original signal domain to a lower-dimensional one in a way that preserves the sparse structure of data. We propose an efficient optimization algorithm and present its non-linear extension based on the kernel methods. One of the key features of our method is that it is computationally efficient as the learning is done in the lower-dimensional space and it discards the irrelevant part of the signal that derails the dictionary learning process. Various experiments show that our method is able to capture the meaningful structure of data and can perform significantly better than many competitive algorithms on signal recovery and object classification tasks. C1 [Nguyen, Hien V.; Patel, Vishal M.; Chellappa, Rama] Univ Maryland, College Pk, MD 20742 USA. [Nasrabadi, Nasser M.] US Army Res Lab, Adelphi, MD USA. RP Nguyen, HV (reprint author), Univ Maryland, College Pk, MD 20742 USA. FU ONR [N00014-12-1-0124] FX The work of HVN, PVM and RC was partially funded by an ONR grant N00014-12-1-0124. NR 29 TC 4 Z9 5 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-33782-6 J9 LECT NOTES COMPUT SC PY 2012 VL 7577 BP 414 EP 427 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Theory & Methods; Imaging Science & Photographic Technology SC Computer Science; Imaging Science & Photographic Technology GA BB3KX UT WOS:000342828800030 ER PT B AU Shay, J AF Shay, Jonathan BE Gerber, DA TI Afterword: A Challenge to Historians SO DISABLED VETERANS IN HISTORY SE Corporealities-Discourses of Disability LA English DT Editorial Material; Book Chapter C1 [Shay, Jonathan] Boston Outpatient Clin, Dept Vet Affairs, Boston, MA USA. [Shay, Jonathan] Marine Corps Trust Study, Boston, MA USA. [Shay, Jonathan] US Army War Coll, Carlisle, PA USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU UNIV MICHIGAN PRESS PI ANN ARBOR PA 839 GREENE ST BOX 1104, ANN ARBOR, MI 48106 USA BN 978-0-472-02888-7; 978-0-472-03508-3 J9 CORPOREALITIES DISCO PY 2012 BP 375 EP 382 D2 10.3998/mpub.3874458 PG 8 WC History Of Social Sciences; Public, Environmental & Occupational Health SC Social Sciences - Other Topics; Public, Environmental & Occupational Health GA BF7OR UT WOS:000384306800017 ER PT J AU Zhang, L Hu, XZ Benedek, DM Fullerton, CS Forsten, RD Naifeh, JA Li, XX Li, H Benevides, KN Ursano, RL AF Zhang, Lei Hu, Xianzhang Benedek, David M. Fullerton, Carol S. Forsten, Robert D. Naifeh, James A. Li, Xiaoxia Li, He Benevides, K. Nikki Ursano, Robert L. TI Dysregulated mitochondria-focused genes in US military service members with PTSD SO EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY LA English DT Meeting Abstract DE PTSD; array; mitochondria; biomarker; PTSD Checklist; military C1 [Zhang, Lei; Hu, Xianzhang; Benedek, David M.; Fullerton, Carol S.; Naifeh, James A.; Li, Xiaoxia; Li, He; Benevides, K. Nikki; Ursano, Robert L.] USUHS, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD USA. [Forsten, Robert D.] DOD, Act Duty US Army Special Operat Unit, Ft Bragg, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CO-ACTION PUBLISHING PI JARFALLA PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN SN 2000-8066 J9 EUR J PSYCHOTRAUMATO JI Eur. J. Psychotraumatol. PY 2012 VL 3 SU 1 DI 10.3402/ejpt.v3i0.19309 PG 2 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA V31FC UT WOS:000208868500178 ER PT J AU East, EW Bogen, C Rashid, M AF East, E. W. Bogen, C. Rashid, M. BE Gudnason, G Scherer, R TI Life-cycle building control SO EWORK AND EBUSINESS IN ARCHITECTURE, ENGINEERING AND CONSTRUCTION LA English DT Proceedings Paper CT 9th European Conference on Product and Process Modelling CY JUL 25-27, 2012 CL Reykjavik, ICELAND AB Efforts to develop and implement open standard information exchange specifications such as the Construction-Operations Building information exchange (COBie) have begun to illustrate how collaborative business processes can be contractually decomposed into discrete information exchanges. Based on the mapping of required information exchanges and the enforcement of specific classes of building information the authors have developed a domain-independent approach for building control. This paper will provide an outline of the life-cycle building control framework and describe a series of projects undertaken by the Engineer Research and Development Center to demonstrate the feasibility of this concept. C1 [East, E. W.; Bogen, C.; Rashid, M.] Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP East, EW (reprint author), Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 9 TC 1 Z9 1 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-415-62128-1 PY 2012 BP 391 EP 396 PG 6 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Construction & Building Technology SC Computer Science; Construction & Building Technology GA BA6JU UT WOS:000337164500051 ER PT B AU Freeman, M L'Heureux, C Furleigh, D Pope, D AF Freeman, Michael L'Heureux, Christopher Furleigh, Dan Pope, Duke BE Freeman, M TI Insurgent and Terrorist Finances in Iraq SO FINANCING TERRORISM: CASE STUDIES LA English DT Article; Book Chapter C1 [Freeman, Michael] Naval Postgrad Sch, Dept Def Anal, Monterey, CA 93943 USA. [L'Heureux, Christopher] US Army, Washington, DC USA. [Furleigh, Dan; Pope, Duke] US Air Force, Washington, DC USA. [Pope, Duke] 18th Flight Test Squadron FLTS, Operat, Hurlburt Field, FL USA. RP Freeman, M (reprint author), Naval Postgrad Sch, Dept Def Anal, Monterey, CA 93943 USA. NR 67 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4262-2; 978-1-4094-4261-5 PY 2012 BP 29 EP 47 PG 19 WC Business, Finance; Criminology & Penology SC Business & Economics; Criminology & Penology GA BC3GW UT WOS:000351635200003 ER PT B AU Reese, JY AF Reese, Justin Y. BE Freeman, M TI Financing the Taliban SO FINANCING TERRORISM: CASE STUDIES LA English DT Article; Book Chapter C1 US Army, Washington, DC 20310 USA. RP Reese, JY (reprint author), US Army, Washington, DC 20310 USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4262-2; 978-1-4094-4261-5 PY 2012 BP 93 EP 109 PG 17 WC Business, Finance; Criminology & Penology SC Business & Economics; Criminology & Penology GA BC3GW UT WOS:000351635200007 ER PT B AU Germann, WA Hartunian, E Polen, RA Mortela, K AF Germann, Wade A. Hartunian, Eric Polen, Richard A. Mortela, Krishnamurti BE Freeman, M TI Terrorist Financing in the Philippines SO FINANCING TERRORISM: CASE STUDIES LA English DT Article; Book Chapter C1 [Germann, Wade A.] US Army Command & Gen Staff Coll CGSC, Ft Leavenworth, KS 66027 USA. [Hartunian, Eric; Polen, Richard A.] US Army, Washington, DC USA. [Hartunian, Eric] Plans 101st Airborne Div, Ft Campbell, KY USA. [Polen, Richard A.] UH 60 Blackhawk Helicopter Co 1st Infantry Div, Austin, TX USA. [Mortela, Krishnamurti] Philippine Army, Manila, Philippines. RP Germann, WA (reprint author), US Army Command & Gen Staff Coll CGSC, Ft Leavenworth, KS 66027 USA. NR 42 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4262-2; 978-1-4094-4261-5 PY 2012 BP 143 EP 162 PG 20 WC Business, Finance; Criminology & Penology SC Business & Economics; Criminology & Penology GA BC3GW UT WOS:000351635200009 ER PT J AU Krzych, U Dalai, S Zarling, S Pichugin, A AF Krzych, Urszula Dalai, Sarat Zarling, Stasya Pichugin, Alexander TI Memory CD8T cells specifc for Plasmodia liver-stage antigens maintain protracted protection against malaria SO FRONTIERS IN IMMUNOLOGY LA English DT Review DE memory T cells; malaria; Plasmodium; liver; IL-15; CD8T cells; mouse model AB Immunologic memory induced by pathogenic agents or vaccinations is inextricably linked to long-lasting protection. Adequately maintained memory T and B cell pools assure a fast, effective, and specific response against re-infections. Studies of immune responses amongst residents of malaria endemic areas suggest that memory responses to Plasmodia antigens appear to be neither adequately developed nor maintained, because persons who survive episodes of childhood malaria remain vulnerable to persistent or intermittent malaria infections. By contrast, multiple exposures of humans and laboratory rodents to radiation-attenuated Plasmodia sporozoites (gamma-spz) induces sterile and long-lasting protection against experimental sporozoite challenge. Protection is associated with MHC-class I-dependent CD8T cells, the key effectors against pre-erythrocytic stage infection. We have adopted the P berghei gamma-spz mouse model to study memory CD8 T cells that are specific for antigens expressed by Pb liver-stage (LS) parasites and are found predominantly in the liver. On the basis of phenotypic and functional characteristics, we have demonstrated that liver CD8 T cells form two subsets: CD44(hi)CD62L(lo)KLIRG-1(+)CD107(+)CD127(-)CD122(lo)CD8 T effector/effector memory (T-E/EM) cells that are the dominant IFN-gamma producers and CD44(hi)CD62L(hi)KLIRG-1(-)CD107(-)CD127(+)CD122(hi)CD8T central memory (T-CM) cells. In this review, we discuss our observations concerning the role of CD8 T-E/EM and CD8 Tan cells in the maintenance of protracted protective immunity against experimental malaria infection. Finally, we present a hypothesis consistent with a model whereby intrahepatic CD8 Tan cells, that are maintained in part by LS-Ag depot and by IL-15-mediated survival and homeostatic proliferation, form a reservoir of cells ready for conscription to CD8T(E/EM) cells needed to prevent re-infections. C1 [Krzych, Urszula; Dalai, Sarat; Zarling, Stasya; Pichugin, Alexander] Walter Reed Army Inst Res, Dept Cellular Immunol, Branch Mil MalariaVaccine Dev, Silver Spring, MD USA. RP Krzych, U (reprint author), Walter Reed Army Inst Res, Dept Cellular Immunol, Bldg 503 ForestGlen Annex, Silver Spring, MD 20910 USA. EM urszula.krzych1@us.army.mil FU National Institutes of Health (UK); US Army Materiel Command FX The authors would like to express their thanks to all the past and the present members of the Krzych lab. In particular, the authors would like to acknowledge Mr. Isaac Chalom, whose work and dedication during the past decade contributed significantly to the results presented in this review. The authors also acknowledge help and support of Dr. D. Gray Heppner. This research was supported in part by a grant from the National Institutes of Health (UK) and the US Army Materiel Command. The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense. NR 109 TC 15 Z9 16 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-3224 J9 FRONT IMMUNOL JI Front. Immunol. PY 2012 VL 3 AR 370 DI 10.3389/fimmu.2012.00370 PG 9 WC Immunology SC Immunology GA V40TQ UT WOS:000209501300365 PM 23233854 ER PT J AU Toth, S Brueggmann, EE Oyler, GA Smith, LA Hines, HB Ahmed, SA AF Toth, Stephen Brueggmann, Ernst E. Oyler, George A. Smith, Leonard A. Hines, Harry B. Ahmed, S. Ashraf TI Tyrosine phosphorylation of botulinunn neurotoxin protease domains SO FRONTIERS IN PHARMACOLOGY LA English DT Article DE botulinum neurotoxin; tyrosine phosphorylation; zinc endoporotease; protease; clostridium botulinum; protein phosphorylation AB Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and in vivo structural differences. Although three-dimensional structures and reaction mechanisms are very similar, the seven serotypes designated A through G vastly vary in their intracellular catalytic stability. To investigate if protein phosphorylation could account for this difference, we employed Src-catalyzed tyrosine phosphorylation of the Lc of six serotypes namely LcA, LcB, LcC1, LcD, LcE, and LcG. Very little phosphorylation was observed with LcD and LcE but LcA, LcB, and LcG were maximally phosphorylated by Src. Phosphorylation of LcA, LcB, and LcG did not affect their secondary and tertiary structures and thermostability significantly. Phosphorylation of Y250 and Y251 made LcA resistant to autocatalysis and drastically reduced its k(cat)/K-m for catalysis. A tyrosine residue present near the essential cysteine at the C-terminal tail of LcA, LcB, and LcG was readily phosphorylated in vitro. Inclusion of a competitive inhibitor protected Y426 of LcA from phosphorylation, shedding light on the role of the C-terminus in the enzyme's substrate or product binding. C1 [Toth, Stephen; Brueggmann, Ernst E.; Hines, Harry B.; Ahmed, S. Ashraf] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Dept Biochem & Cell Biol, Ft Detrick, MD USA. [Oyler, George A.] Synapt Res LLC, Baltimore, MD USA. [Smith, Leonard A.] Off Chief Scientist, Ft Detrick, MD USA. RP Ahmed, SA (reprint author), USAMRIID, 1425 Porter St, Ft Detrick, MD 21702 USA. EM syed.ahmed@amedd.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense [CBS.MEDBIO.01.10.RD.002, JSTOCBD3.10012_06_RD_B] FX We thank Mr. Matthew Ludivico for conducting the UPLerm analyses, kinetic and circular dichroism experiments, and Dr. Mizanur Rahman for careful reading of the manuscript. This project received support from the Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense (Grant #s CBS.MEDBIO.01.10.RD.002 and JSTOCBD3.10012_06_RD_B to S. Ashraf Ahmed). Opinions, interpretations, conclusions, and recommendations are those of the author and are not necessarily endorsed by the U.S. Army. NR 59 TC 7 Z9 7 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1663-9812 J9 FRONT PHARMACOL JI Front. Pharmacol. PY 2012 VL 3 AR UNSP 102 DI 10.3389/fphar.2012.00102 PG 12 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA V35XE UT WOS:000209177700098 PM 22675300 ER PT J AU Barnes, JN Matzek, LJ Charkoudian, N Joyner, MJ Curry, TB Hart, EC AF Barnes, Jill N. Matzek, Luke J. Charkoudian, Nisha Joyner, Michael J. Curry, Timothy B. Hart, Emma C. TI Association of cardiac baroreflex sensitivity with blood pressure transients: influence of sex and menopausal status SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE cardiovagal; sympathetic nerve activity; aging; blood pressure regulation AB The magnitude of decrease in blood pressure (BP) during a vasoactive drug bolus may be associated with the calculated baroreflex sensitivity (BRS). The purpose of the present study was to evaluate whether sympathetic and/or cardiac BRS relates to the extent of change in BP and whether this was altered by sex hormones. Fifty-one young women (27 +/- 1 years), 14 older women (58 +/- 1 years), and 36 young men (27 +/- 1 years) were studied. Heart rate, BP and muscle sympathetic nerve activity (MSNA) were monitored. Sympathetic BRS was analyzed using the slope of the MSNA-diastolic blood pressure (DBP) relationship and cardiac BRS was analyzed using the R-R interval-systolic blood pressure (SBP) relationship. Young women and men had similar mean arterial pressures (MAP 91 +/- 1 vs. 90 +/- 1 mmHg), cardiac BRS (19 +/- 1 vs. 21 +/- 2 ms/mmHg and sympathetic BRS (-6 +/- 1 vs. -7 +/- 1 AU/beat/mmHg), respectively. Older women had higher MAP (104 +/- 4 mmHg, p < 0.05) and lower cardiac BRS (7 +/- 1 ms/mmHg, p < 0.05), but similar sympathetic BRS (-8 +/- 1 AU/beat/mmHg). There was no association between BP transients with either cardiac or sympathetic BRS in young women. In the older women, the drop in SBP DBP and MAP were associated with cardiac BRS (r = 0.60, r = 0.59, and r = 0.70, respectively; p < 0.05), but not sympathetic BRS. The decrease in SBP was positively related to cardiac BRS in young men (r = 0.41; p < 0.05). However, there was no relationship between the decrease in BP and sympathetic BRS. This indicates that older women and young men with low cardiac BRS have larger transients in BP during nitroprusside. This suggests a more prominent role for cardiac (as opposed to sympathetic) BRS in responding to acute BP changes in young men and older women. The fact that these relationships do not exist in young women suggest that the female sex hormones influence baroreflex responses. C1 [Barnes, Jill N.; Matzek, Luke J.; Joyner, Michael J.; Curry, Timothy B.; Hart, Emma C.] Mayo Clin, Dept Anesthesiol, Human Integrat Physiol Lab, Rochester, MN 55905 USA. [Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA. RP Barnes, JN (reprint author), Mayo Clin, Dept Anesthesiol, Human Integrat Physiol Lab, 200 1st St SouthWest,Joseph 4-184, Rochester, MN 55905 USA. EM barnes.jill@mayo.edu OI Hart, Emma/0000-0002-4534-9586 NR 25 TC 9 Z9 9 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2012 VL 3 AR UNSP 187 DI 10.3389/fphys.2012.00187 PG 6 WC Physiology SC Physiology GA V35UH UT WOS:000209173000184 PM 22701103 ER PT J AU Lovecchio, E Allegrini, P Geneston, E West, BJ Grigolini, P AF Lovecchio, Elisa Allegrini, Paolo Geneston, Elvis West, Bruce J. Grigolini, Paolo TI From self-organized to extended criticality SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE SOC; extended criticality; neural networks; cooperation AB We address the issue of criticality that is attracting the attention of an increasing number of neurophysiologists. Our main purpose is to establish the specific nature of some dynamical processes that although physically different, are usually termed as "critical," and we focus on those characterized by the cooperative interaction of many units. We notice that the term "criticality" has been adopted to denote both noise-induced phase transitions and Self-Organized Criticality (SOC) with no clear connection with the traditional phase transitions, namely the transformation of a thermodynamic system from one state of matter to another. We notice the recent attractive proposal of extended criticality advocated by Bailly and Longo, which is realized through a wide set of critical points rather than emerging as a singularity from a unique value of the control parameter. We study a set of cooperatively firing neurons and we show that for an extended set of interaction couplings the system exhibits a form of temporal complexity similar to that emerging at criticality from ordinary phase transitions. This extended criticality regime is characterized by three main properties: (i) In the ideal limiting case of infinitely large time period, temporal complexity corresponds to Mittag-Leffler complexity; (ii) For large values of the interaction coupling the periodic nature of the process becomes predominant while maintaining to some extent, in the intermediate time asymptotic region, the signature of complexity; (iii) Focusing our attention on firing neuron avalanches, we find two of the popular SOC properties, namely the power indexes 2 and 1.5 respectively for time length and for the intensity of the avalanches. We derive the main conclusion that SOC emerges from extended criticality, thereby explaining the experimental observation of Plenz and Beggs: avalanches occur in time with surprisingly regularity, in apparent conflict with the temporal complexity of physical critical points. C1 [Lovecchio, Elisa; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Allegrini, Paolo] Scuola Super Sant Anna, Ctr EXTREME, Pisa, Italy. [Allegrini, Paolo] CNR, Ist Fisiol Clin, I-56124 Pisa, Italy. [Geneston, Elvis] La Sierra Univ, Dept Phys, Riverside, CA USA. [West, Bruce J.] US Army Res Off, Informat Sci Directorate, Durham, NC USA. RP Allegrini, P (reprint author), CNR, Ist Fisiol Clin, Via Moruzzi 1, I-56124 Pisa, Italy. EM allegrini@ifc.cnr.it; grigo@unt.edu RI Allegrini, Paolo/C-1876-2012 OI Allegrini, Paolo/0000-0002-5476-9005 FU ARO [W911NF-08-1-0177] FX Elisa Lovecchio an d Paolo Grigolini thankfully acknowledge financial support from ARO through Grant No. W911NF-08-1-0177. NR 43 TC 11 Z9 11 U1 0 U2 7 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2012 VL 3 AR UNSP 98 DI 10.3389/fphys.2012.00098 PG 9 WC Physiology SC Physiology GA V35UH UT WOS:000209173000095 PM 22557972 ER PT J AU Mayo, M Abdelzaher, AF Perkins, EJ Ghosh, P AF Mayo, Michael Abdelzaher, Ahmed F. Perkins, Edward J. Ghosh, Preetam TI Motif participation by genes in E-coli transcriptional networks SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE gene regulatory networks; feed-forward loop motif; complex networks; preferential attachment network models; motif centrality AB Motifs are patterns of recurring connections among the genes of genetic networks that occur more frequently than would be expected from randomized networks with the same degree sequence. Although the abundance of certain three-node motifs, such as the feed-forward loop, is positively correlated with a networks' ability to tolerate moderate disruptions to gene expression, little is known regarding the connectivity of individual genes participating in multiple motifs. Using the transcriptional network of the bacterium Escherichia coli, we investigate this feature by reconstructing the distribution of genes participating in feed-forward loop motifs from its largest connected network component. We contrast these motif participation distributions with those obtained from model networks built using the preferential attachment mechanism employed by many biological and man-made networks. We report that, although some of these model networks support a motif participation distribution that appears qualitatively similar to that obtained from the bacterium E. coli, the probability for a node to support a feed-forward loop motif may instead be strongly influenced by only a few master transcriptional regulators within the network. From these analyses we conclude that such master regulators may be a crucial ingredient to describe coupling among feed-forward loop motifs in transcriptional regulatory networks. C1 [Mayo, Michael; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Abdelzaher, Ahmed F.; Ghosh, Preetam] Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA USA. RP Mayo, M (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM michael.l.mayo@usace.army.mil FU US Army's Environmental Quality and Installations 6.1 basic research program; [NSF-1143737] FX We thank the reviewers for insightful comments and helpful suggestions. This work was supported by grant number NSF-1143737, and the US Army's Environmental Quality and Installations 6.1 basic research program. The Chief of Engineers approved this material for publication. NR 40 TC 5 Z9 5 U1 0 U2 3 PU FRONTIERS MEDIA SA PI LAUSANNE PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2012 VL 3 AR 357 DI 10.3389/fphys.2012.00357 PG 11 WC Physiology SC Physiology GA V35UH UT WOS:000209173000351 PM 23055976 ER PT J AU Ryan, KL Rickards, CA Hinojosa-Laborde, C Cooke, WH Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Hinojosa-Laborde, Carmen Cooke, William H. Convertino, Victor A. TI Sympathetic responses to central hypovolemia: new insights from microneurographic recordings SO FRONTIERS IN PHYSIOLOGY LA English DT Review DE hemorrhage; sympathetic activity; MSNA; baroreflex function; central hypovolemia; LBNP AB Hemorrhage remains a major cause of mortality following traumatic injury in both military and civilian settings. Lower body negative pressure (LBNP) has been used as an experimental model to study the compensatory phase of hemorrhage in conscious humans, as it elicits central hypovolemia like that induced by hemorrhage. One physiological compensatory mechanism that changes during the course of central hypovolemia induced by both LBNP and hemorrhage is a baroreflex-mediated increase in muscle sympathetic nerve activity (MSNA), as assessed with microneurography. The purpose of this review is to describe recent results obtained using microneurography in our laboratory as well as those of others that have revealed new insights into mechanisms underlying compensatory increases in MSNA during progressive reductions in central blood volume and how MSNA is altered at the point of hemodynamic decompensation. We will also review recent work that has compared direct MSNA recordings with non-invasive surrogates of MSNA to determine the appropriateness of using such surrogates in assessing the clinical status of hemorrhaging patients. C1 [Ryan, Kathy L.; Hinojosa-Laborde, Carmen; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.; Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. RP Ryan, KL (reprint author), US Army, Inst Surg Res, Div Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA. EM kathy.ryan@amedd.army.mil FU Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command FX The authors thank our research subjects, who cheerfully cooperated with the experiments described herein, and Mr. Gary Muniz for his superb technical assistance. All studies performed at the U.S. Army Institute of Surgical Research were conducted under protocols reviewed and approved by the US Army Medical Research and Materiel Command Institutional Review Board and in accordance with the approved protocols. This work was supported by the Combat Casualty Care Research Area Directorate of the US Army Medical Research and Materiel Command. NR 127 TC 6 Z9 6 U1 0 U2 2 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2012 VL 3 AR UNSP 110 DI 10.3389/fphys.2012.00110 PG 14 WC Physiology SC Physiology GA V35UH UT WOS:000209173000107 PM 22557974 ER PT J AU Turalska, M Geneston, E West, BJ Allegrini, P Grigolini, P AF Turalska, Malgorzata Geneston, Elvis West, Bruce J. Allegrini, Paolo Grigolini, Paolo TI Cooperation-induced topological complexity: a promising road to fault tolerance and Hebbian learning SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE criticality; cooperation; complex topology; inverse power law AB According to an increasing number of researchers intelligence emerges from criticality as a consequence of locality breakdown and long-range correlation, well known properties of phase transition processes. We study a model of interacting units, as an idealization of real cooperative systems such as the brain or a flock of birds, for the purpose of discussing the emergence of long-range correlation from the coupling of any unit with its nearest neighbors. We focus on the critical condition that has been recently shown to maximize information transport and we study the topological structure of the network of dynamically linked nodes. Although the topology of this network depends on the arbitrary choice of correlation threshold, namely the correlation intensity selected to establish a link between two nodes; the numerical calculations of this paper afford some important indications on the dynamically induced topology. The first important property is the emergence of a perception length as large as the flock size, thanks to some nodes with a large number of links, thus playing the leadership role. All the units are equivalent and leadership moves in time from one to another set of nodes, thereby insuring fault tolerance. Then we focus on the correlation threshold generating a scale-free topology with power index v 1 and we find that if this topological structure is selected to establish consensus through the linked nodes, the control parameter necessary to generate criticality is close to the critical value corresponding to the all-to-all coupling condition. We find that criticality in this case generates also a third state, corresponding to a total lack of consensus. However, we make a numerical analysis of the dynamically induced network, and we find that it consists of two almost independent structures, each of which is equivalent to a network in the all-to-all coupling condition. This observation confirms that cooperation makes the system evolve toward favoring consensus topological structures. We argue that these results are compatible with both Hebbian learning and fault tolerance. C1 [Turalska, Malgorzata; Grigolini, Paolo] Univ N Texas, Dept Phys, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Geneston, Elvis] La Sierra Univ, Dept Phys, Riverside, CA USA. [West, Bruce J.] US Army Res Off, Informat Sci Directorate, Durham, NC USA. [Allegrini, Paolo] CNR, Ist Fisiol Clin, I-56124 Pisa, Italy. RP Allegrini, P (reprint author), CNR, Ist Fisiol Clin, Via Moruzzi 1, I-56124 Pisa, Italy. EM allegrip@df.unipi.it RI Allegrini, Paolo/C-1876-2012 OI Allegrini, Paolo/0000-0002-5476-9005 FU ARO [W911NF1110478] FX Malgorzata Turalska, Elvis Geneston, and Paolo Grigolini thankfully acknowledge financial support from ARO through Grant #W911NF1110478. NR 37 TC 10 Z9 10 U1 2 U2 5 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2012 VL 3 AR UNSP 52 DI 10.3389/fphys.2012.00052 PG 7 WC Physiology SC Physiology GA V35UH UT WOS:000209173000051 PM 22438845 ER PT J AU West, BJ Grigolini, P AF West, Bruce J. Grigolini, Paolo TI Networking of psychophysics, psychology, and neurophysiology SO FRONTIERS IN PHYSIOLOGY LA English DT Editorial Material C1 [West, Bruce J.] US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. [Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. RP West, BJ (reprint author), US Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. EM bruce.j.west@att.net NR 10 TC 0 Z9 0 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-042X J9 FRONT PHYSIOL JI Front. Physiol. PY 2012 VL 3 AR UNSP 423 DI 10.3389/fphys.2012.00423 PG 2 WC Physiology SC Physiology GA V35UH UT WOS:000209173000416 PM 23133424 ER PT J AU Cummiskey, K Kuiper, S Sturdivant, R AF Cummiskey, Kevin Kuiper, Shonda Sturdivant, Rodney TI Using classroom data to teach students about data cleaning and testing assumptions SO FRONTIERS IN PSYCHOLOGY LA English DT Article DE Guided Interdisciplinary Statistics Games and Labs; messy data; model assumptions AB This paper discusses the influence that decisions about data cleaning and violations of statistical assumptions can have on drawing valid conclusions to research studies. The datasets provided in this paper were collected as part of a National Science Foundation grant to design online games and associated labs for use in undergraduate and graduate statistics courses that can effectively illustrate issues not always addressed in traditional instruction. Students play the role of a researcher by selecting from a wide variety of independent variables to explain why some students complete games faster than others. Typical project data sets are "messy," with many outliers (usually from some students taking much longer than others) and distributions that do not appear normal. Classroom testing of the games over several semesters has produced evidence of their efficacy in statistics education. The projects tend to be engaging for students and they make the impact of data cleaning and violations of model assumptions more relevant. We discuss the use of one of the games and associated guided lab in introducing students to issues prevalent in real data and the challenges involved in data cleaning and dangers when model assumptions are violated. C1 [Cummiskey, Kevin; Sturdivant, Rodney] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Kuiper, Shonda] Grinnell Coll, Dept Math & Stat, Grinnell, IA 50112 USA. RP Cummiskey, K (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM kevin.cummiskey@usma.edu NR 24 TC 0 Z9 0 U1 1 U2 3 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PY 2012 VL 3 AR 354 DI 10.3389/fpsyg.2012.00354 PG 8 WC Psychology, Multidisciplinary SC Psychology GA V31DJ UT WOS:000208864000070 PM 23055992 ER PT J AU Tower-Richardi, SM Brunye, TT Gagnon, SA Mahoney, CR Taylor, HA AF Tower-Richardi, Sarah M. Brunye, Tad T. Gagnon, Stephanie A. Mahoney, Caroline R. Taylor, Holly A. TI Abstract spatial concept priming dynamically influences real-world actions SO FRONTIERS IN PSYCHOLOGY LA English DT Article DE spatial cognition; embodied cognition; masked priming; mouse tracking; abstract concepts AB Experienced regularities in our perceptions and actions play important roles in grounding abstract concepts such as social status, time, and emotion. Might we similarly ground abstract spatial concepts in more experienced-based domains? The present experiment explores this possibility by implicitly priming abstract spatial terms (north, south, east, west) and then measuring participants' hand movement trajectories while they respond to a body-referenced spatial target (up, down, left, right) in a verbal (Exp. 1) or spatial (Exp. 2) format. Results from two experiments demonstrate temporally dynamic and prime biased movement trajectories when the primes are incongruent with the targets (e.g., north left, west up). That is, priming abstract coordinate directions influences subsequent actions in response to concrete target directions. These findings provide the first evidence that abstract concepts of world-centered coordinate axes are implicitly understood in the context of concrete body-referenced axes; critically, this abstract-concrete relationship manifests in motor movements, and may have implications for spatial memory organization. C1 [Tower-Richardi, Sarah M.; Brunye, Tad T.; Gagnon, Stephanie A.; Mahoney, Caroline R.] US Army, Cognit Sci Team, NSRDEC, Natick, MA 01760 USA. [Tower-Richardi, Sarah M.; Brunye, Tad T.; Gagnon, Stephanie A.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Gagnon, Stephanie A.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tbrunye@alumni.tufts.edu NR 86 TC 5 Z9 5 U1 0 U2 5 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 1664-1078 J9 FRONT PSYCHOL JI Front. Psychol. PY 2012 VL 3 AR 361 DI 10.3389/fpsyg.2012.00361 PG 12 WC Psychology, Multidisciplinary SC Psychology GA V31DJ UT WOS:000208864000077 PM 23060831 ER PT S AU Lelis, A Green, R El, M Habersat, D AF Lelis, A. Green, R. El, M. Habersat, D. BE Shenai, K Dudley, M Ohtani, N Bakowski, M Garg, R TI Effect of Stress and Measurement Conditions in Determining the Reliability of SiC Power MOSFETs SO GALLIUM NITRIDE AND SILICON CARBIDE POWER TECHNOLOGIES 2 SE ECS Transactions LA English DT Proceedings Paper CT 2nd Symposium on Gallium Nitride (GaN) and Silicon Carbide (SiC) Power Technologies as part of ECS Fall Meeting CY OCT 07-12, 2012 CL Honolulu, HI SP ECS ID THRESHOLD-VOLTAGE INSTABILITY; HIGH-TEMPERATURE RELIABILITY; DEPENDENCE AB A review of the threshold-voltage instability effect in SiC MOSFETs and the issues regarding the effect of stress and measurement conditions in determining the reliability of these devices is presented. The complex response of near-interfacial oxide traps, as well as other interfacial charge, to bias and temperature with time is discussed, and how it affects the accuracy of reliability measurements. The strong dependence on measurement speed is also addressed. All these issues point to the need for a separate, appropriate reliability test standard for SiC MOSFETs, rather than using the existing standard based on Si technology. C1 [Lelis, A.; Green, R.; El, M.; Habersat, D.] US Army Res Lab, Adelphi, MD 20783 USA. RP Lelis, A (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 14 TC 2 Z9 2 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-351-3 J9 ECS TRANSACTIONS PY 2012 VL 50 IS 3 BP 251 EP 256 DI 10.1149/05003.0251ecst PG 6 WC Crystallography; Electrochemistry; Materials Science, Characterization & Testing SC Crystallography; Electrochemistry; Materials Science GA BA7TJ UT WOS:000337755900027 ER PT S AU Tompkins, RP Smith, JR Derenge, MA Kirchner, KW Zhou, S Jones, KA Metzger, R Leach, J Suvarna, P Tungare, M Shahedipour, F AF Tompkins, R. P. Smith, J. R. Derenge, M. A. Kirchner, K. W. Zhou, S. Jones, K. A. Metzger, R. Leach, J. Suvarna, P. Tungare, M. Shahedipour, F. BE Shenai, K Dudley, M Ohtani, N Bakowski, M Garg, R TI Achieving Low Doped (< 10(16)) GaN with Large Breakdown Voltages (similar to 1000 V) SO GALLIUM NITRIDE AND SILICON CARBIDE POWER TECHNOLOGIES 2 SE ECS Transactions LA English DT Proceedings Paper CT 2nd Symposium on Gallium Nitride (GaN) and Silicon Carbide (SiC) Power Technologies as part of ECS Fall Meeting CY OCT 07-12, 2012 CL Honolulu, HI SP ECS ID FIELD-EFFECT TRANSISTORS; MOLECULAR-BEAM EPITAXY; VAPOR-PHASE EPITAXY; CURRENT COLLAPSE; CARBON; VACANCIES; DISLOCATIONS; SILICON; LEAKAGE; DONORS AB Point defects in the GaN cause premature breakdown in GaN Schottky diodes at least to the same extent as dislocations do. The most likely cause is impact ionization of deep acceptors. A primary deep acceptor in MOCVD-grown GaN is C. Another is a Ga vacancy, which is likely to be the primary deep acceptor in HVPE-grown material. Lower net carrier concentrations, and therefore larger breakdown voltages, can be achieved in the HVPE material. C1 [Tompkins, R. P.; Smith, J. R.; Derenge, M. A.; Kirchner, K. W.; Zhou, S.; Jones, K. A.] Army Res Lab, Adelphi, MD 20783 USA. [Metzger, R.; Leach, J.] Kyma Technol, Raleigh, NC 27617 USA. [Suvarna, P.; Tungare, M.; Shahedipour, F.] SUNY Albany, CNSE, Albany, NY 12203 USA. RP Tompkins, RP (reprint author), Army Res Lab, Adelphi, MD 20783 USA. NR 32 TC 0 Z9 0 U1 0 U2 3 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-351-3 J9 ECS TRANSACTIONS PY 2012 VL 50 IS 3 BP 297 EP 305 DI 10.1149/05003.0297ecst PG 9 WC Crystallography; Electrochemistry; Materials Science, Characterization & Testing SC Crystallography; Electrochemistry; Materials Science GA BA7TJ UT WOS:000337755900032 ER PT S AU Keebler, JR Jentsch, F Fincannon, T Hudson, I AF Keebler, Joseph R. Jentsch, Florian Fincannon, Thomas Hudson, Irwin GP Assoc Comp Machinery TI Applying Team Heuristics to Future Human-Robot Systems SO HRI'12: PROCEEDINGS OF THE SEVENTH ANNUAL ACM/IEEE INTERNATIONAL CONFERENCE ON HUMAN-ROBOT INTERACTION SE ACMIEEE International Conference on Human-Robot Interaction LA English DT Proceedings Paper CT 7th ACM/IEEE International Conference on Human-Robot Interaction (HRI) CY MAR 05-08, 2012 CL Boston, MA SP Assoc Comp Machinery, IEEE, ACM SIGCHI, ACM SIGART, HFES, AAAI, IEEE Robot & Automat DE HRI; Human-robot teams; team training AB In this paper we briefly describe teaming heuristics as they are applied to human-human teams, and demonstrate their adaptability to human-robot (HR) teams. We discuss a framework developed from Salas's models on teamwork and team training. As HRI technology moves from tele-operative control methods to teamwork with intelligent robots, it is pertinent to properly integrate knowledge about teams into the development of robotic systems. This should lead to highly effective team systems, and may provide insight into the design of robotic entities and system protocols. C1 [Keebler, Joseph R.; Jentsch, Florian; Fincannon, Thomas] Univ Cent Florida, 3100 Technol Pkwy, Orlando, FL 32826 USA. [Hudson, Irwin] Army Res Lab, Orlando, FL 32826 USA. RP Keebler, JR (reprint author), Univ Cent Florida, 3100 Technol Pkwy, Orlando, FL 32826 USA. EM joekeebler@gmail.com; fjentsch@mail.ucf.edu; t_fincannon@yahoo.com; Irwin.hudson@us.army.mil NR 7 TC 0 Z9 0 U1 0 U2 1 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036-9998 USA SN 2167-2121 BN 978-1-4503-1063-5 J9 ACMIEEE INT CONF HUM PY 2012 BP 169 EP 170 PG 2 WC Engineering, Electrical & Electronic; Robotics SC Engineering; Robotics GA BG9JL UT WOS:000393315300046 ER PT S AU Prasov, Z AF Prasov, Zahar GP Assoc Comp Machinery TI Shared Gaze in Remote Spoken HRI During Distributed Military Operations SO HRI'12: PROCEEDINGS OF THE SEVENTH ANNUAL ACM/IEEE INTERNATIONAL CONFERENCE ON HUMAN-ROBOT INTERACTION SE ACMIEEE International Conference on Human-Robot Interaction LA English DT Proceedings Paper CT 7th ACM/IEEE International Conference on Human-Robot Interaction (HRI) CY MAR 05-08, 2012 CL Boston, MA SP Assoc Comp Machinery, IEEE, ACM SIGCHI, ACM SIGART, HFES, AAAI, IEEE Robot & Automat DE Shared Gaze; Joint Attention; HRI; Remote Communication AB Collaboration between distributed human and robot partners during military operations is becoming more necessary. In order to enable efficient real-time communication, it is important to develop user interfaces that support robust spoken language understanding capabilities. As a step toward achieving this objective, this work examines the role of shared gaze between a human and robot during remote spoken collaboration engaged in a distributed military operations. Preliminary results have shown that an interface that supports shared gaze between a human and robot for a remote collaborative HRI search task has potential to improve automated language understanding as well as task efficiency. C1 [Prasov, Zahar] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Prasov, Z (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM zahar.prasov.ctr@us.army.mil FU U. S. Army Research Laboratory Postdoctoral Fellowship Program FX This research was supported in part by an appointment to the U. S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universitites through a contract with the U. S. Army Research Laboratory. NR 11 TC 0 Z9 0 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036-9998 USA SN 2167-2121 BN 978-1-4503-1063-5 J9 ACMIEEE INT CONF HUM PY 2012 BP 211 EP 212 PG 2 WC Engineering, Electrical & Electronic; Robotics SC Engineering; Robotics GA BG9JL UT WOS:000393315300067 ER PT B AU Marston, D AF Marston, Daniel BE Jeffreys, A Rose, P TI The 20th Indian Division in French Indo-China SO INDIAN ARMY, 1939-47: EXPERIENCE AND DEVELOPMENT LA English DT Article; Book Chapter C1 [Marston, Daniel] US Army Command & Gen Staff Coll, Art War, Ft Leavenworth, KS USA. [Marston, Daniel] Royal Hist Soc, London, England. RP Marston, D (reprint author), Australian Natl Univ, Strateg & Def Studies Ctr, Canberra, ACT 0200, Australia. NR 34 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-3554-9; 978-1-4094-3553-2 PY 2012 BP 157 EP 178 PG 22 WC History SC History GA BC3UX UT WOS:000352006000010 ER PT S AU Dodge, R Coronges, K Rovira, E AF Dodge, Ronald Coronges, Kathryn Rovira, Ericka BE Gritzalis, D Furnell, S Theoharidou, M TI Empirical Benefits of Training to Phishing Susceptibility SO INFORMATION SECURITY AND PRIVACY RESEARCH SE IFIP Advances in Information and Communication Technology LA English DT Proceedings Paper CT 27th IFIP TC11 International Information Security and Privacy Conference (IFIP SEC) CY JUN 04-06, 2012 CL Heraklion, GREECE SP IFIP AB Social engineering continues to be the most worrisome vulnerability to organizational networks, data, and services. The most successful form of social engineering is the practice of phishing. In the last several years, a multitude of phishing variations have been defined including pharming, spear phishing, and whaling. While each has a specific reason for its success, they all rely on a user failing to exercise due diligence and responsibility. In this paper, we report on a recent phishing experiments where the effects of training were evaluated as well as gathering demographic data to explore the susceptibility of given groups. C1 [Dodge, Ronald; Coronges, Kathryn; Rovira, Ericka] US Mil Acad, West Point, NY 10996 USA. RP Dodge, R (reprint author), US Mil Acad, West Point, NY 10996 USA. EM ronald.dodge@usma.edu; kate.coronges@usma.edu; ericka.rovira@usma.edu NR 9 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1868-4238 BN 978-3-642-30436-1 J9 IFIP ADV INF COMM TE PY 2012 VL 376 BP 457 EP 464 PG 8 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Telecommunications SC Computer Science; Telecommunications GA BD9JP UT WOS:000364775300037 ER PT S AU Fu, R Pattison, J Chen, A Nayfeh, O AF Fu, Richard Pattison, James Chen, Andrew Nayfeh, Osama BE Andresen, BF Fulop, GF Norton, PR TI Mercury cadmium telluride (HgCdTe) passivation by advanced thin conformal Al2O3 films SO INFRARED TECHNOLOGY AND APPLICATIONS XXXVIII, PTS 1 AND 2 SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Infrared Technology and Applications XXXVIII CY APR 23-27, 2012 CL Baltimore, MD SP SPIE DE Atomic Layer Deposition (ALD); Plasma enhanced ALD; Al2O3 film; Mercury Cadmium Telluride (HgCdTe or MCT); Passivation ID ATOMIC LAYER DEPOSITION; TEMPERATURE AB HgCdTe passivation process must be performed at low temperature in order to reduce Hg depletion. Low temperature plasma enhanced atomic layer deposition (PE-ALD) is an emerging deposition technology for thin highly conformal films to meet the demand. Room temperature PE-ALD Al2O3 film's passivation on HgCdTe has been studied. Conformal film was investigated through SEM images of the Al2O3 film deposited onto high aspect ratio features dry etched into HgCdTe. Minority carrier lifetime was measured and compared by photoconductive decay transients of HgCdTe before and after deposition. Room temperature ALD Al2O3 film increased the minority carrier lifetime of HgCdTe. C1 [Fu, Richard; Pattison, James; Chen, Andrew; Nayfeh, Osama] USA, Res Lab, Adelphi, MD 20783 USA. RP Fu, R (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9031-5 J9 PROC SPIE PY 2012 VL 8353 AR 83532I DI 10.1117/12.918605 PG 7 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BBE01 UT WOS:000306604400089 ER PT J AU Fredette, TJ Foran, CM Brasfield, SM Suedel, BC AF Fredette, Thomas J. Foran, Christy M. Brasfield, Sandra M. Suedel, Burton C. TI Environmental engineering of navigation infrastructure: A survey of existing practices, challenges, and potential opportunities SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article AB Navigation infrastructure such as channels, jetties, river training structures, and lock-and-dam facilities are primary components of a safe and efficient water transportation system. Planning for such infrastructure has until recently involved efforts to minimize impacts on the environment through a standardized environmental assessment process. More recently, consistent with environmental sustainability concepts, planners have begun to consider how such projects can also be constructed with environmental enhancements. This study examined the existing institutional conditions within the US Army Corps of Engineers and cooperating federal agencies relative to incorporating environmental enhancements into navigation infrastructure projects. The study sought to (1) investigate institutional attitudes towards the environmental enhancement of navigation infrastructure (EENI) concept, (2) identify potential impediments to implementation and solutions to such impediments, (3) identify existing navigation projects designed with the express intent of enhancing environmental benefit in addition to the primary project purpose, (4) identify innovative ideas for increasing environmental benefits for navigation projects, (5) identify needs for additional technical information or research, and (6) identify laws, regulations, and policies that both support and hinder such design features. The principal investigation tool was an Internet-based survey with 53 questions. The survey captured a wide range of perspectives on the EENI concept including ideas, concerns, research needs, and relevant laws and policies. Study recommendations included further promotion of the concept of EENI to planners and designers, documentation of existing projects, initiation of pilot studies on some of the innovative ideas provided through the survey, and development of national goals and interagency agreements to facilitate implementation. Integr Environ Assess Manag 2012;8:11. (c) 2011 SETAC RP Fredette, TJ (reprint author), USA, Environm Lab, Corps Engineers, Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM thomas.j.fredette@usace.army.mil NR 15 TC 0 Z9 0 U1 2 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JAN PY 2012 VL 8 IS 1 BP 175 EP 182 DI 10.1002/ieam.270 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 869LS UT WOS:000298600100017 PM 21796771 ER PT B AU Goldberg, B Brawner, KW Holden, HK Sottilare, RA AF Goldberg, Benjamin Brawner, Keith W. Holden, Heather K. Sottilare, Robert A. BE Bruzzone, A Buck, W Longo, F Sokolowski, JA Sottilare, R TI ADAPTIVE GAME-BASED TUTORING: MECHANISMS FOR REAL-TIME FEEDBACK AND ADAPTATION SO INTERNATIONAL DEFENSE AND HOMELAND SECURITY SIMULATION WORKSHOP (DHSS 2012) LA English DT Proceedings Paper CT International Defense and Homeland Security Simulation Workshop (DHSS) CY SEP 19-21, 2012 CL Vienna, AUSTRIA SP Univ Genoa, Liophant Simulat, Simulat Team, Int Mediterranean & Latin Amer Council Simulat, Univ Calabria, DIMEG, Lab Enterprise Solut, Modeling & Simulat Ctr, Modeling & Simulat Ctr Excellence, Riga Tech Univ, Latvian Simulat Ctr, Logism, Lab Sci Informat Syst, Movimento Italiano Modellazione & Simulazione, Univ Perugia, MITIM Perugia Ctr, LAMCE COPPE UFRJ, Brasilian Simulat Ctr, McLeod Inst Technol & Interoperable Modeling & Simulat, Genoa Ctr, McLeod Modeling & Simulat Network, Latvian Simulat Soc, Ecole Superieure Ingn Sci Appliquees, Fac Ciencias Exactas, Ingn & Agrimensura, Univ La Laguna, CIFASIS CONICET UNR UPCAM, Inst Syst & Technologies Informat, Control & Commun, Natl Russian Simulat Soc, CEA IFAC, IEEE, Cent & S Italy Sect Chapter, CAL TEK SRL, Liotech Ltd, Mast Srl DE adaptive tutoring; game-based training; real-time; feedback AB The advantages associated with game-based training platforms in the military domain are apparent. They enable Soldiers to practice the application of knowledge and skills in a safe simulated environment across multiple domains. However, simulation-and game-based training is limited in their ability to stand as instructional tools in the absence of live monitoring and instruction. Through the integration of computer-based tutoring technologies, game-based training has the potential to facilitate practice of executing tasks while having mechanisms to guide performance and facilitate instruction through embedded pedagogical functions. This poses many challenges that must be addressed. In this paper, the authors highlight desired functions and interactions between game-based platforms and computer-based tutoring architectures for support of real-time guidance and adaptation. Games provide unique environments for applying adaptations to specific scenario elements and for providing feedback on performance in real-time. C1 [Goldberg, Benjamin; Brawner, Keith W.; Holden, Heather K.; Sottilare, Robert A.] US Army Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr, Adelphi, MD 20783 USA. RP Goldberg, B (reprint author), US Army Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr, Adelphi, MD 20783 USA. EM benjamin.s.goldberg@us.army.mil; robert.sottilare@us.army.mil; keith.w.brawner@us.army.mil; heather.k.holden@us.army.mil NR 23 TC 0 Z9 0 U1 0 U2 0 PU DIME UNIV GENOA PI GENOVA PA VIA OPERA PLA, 15-15A, GENOVA, 16145, ITALY BN 978-88-97999-00-3; 978-88-97999-08-9 PY 2012 BP 13 EP 18 PG 6 WC Operations Research & Management Science SC Operations Research & Management Science GA BG9CX UT WOS:000393065300003 ER PT B AU Sottilare, RA AF Sottilare, Robert A. BE Bruzzone, A Buck, W Longo, F Sokolowski, JA Sottilare, R TI CONSIDERATIONS IN THE DEVELOPMENT OF AN ONTOLOGY FOR A GENERALIZED INTELLIGENT FRAMEWORK FOR TUTORING SO INTERNATIONAL DEFENSE AND HOMELAND SECURITY SIMULATION WORKSHOP (DHSS 2012) LA English DT Proceedings Paper CT International Defense and Homeland Security Simulation Workshop (DHSS) CY SEP 19-21, 2012 CL Vienna, AUSTRIA SP Univ Genoa, Liophant Simulat, Simulat Team, Int Mediterranean & Latin Amer Council Simulat, Univ Calabria, DIMEG, Lab Enterprise Solut, Modeling & Simulat Ctr, Modeling & Simulat Ctr Excellence, Riga Tech Univ, Latvian Simulat Ctr, Logism, Lab Sci Informat Syst, Movimento Italiano Modellazione & Simulazione, Univ Perugia, MITIM Perugia Ctr, LAMCE COPPE UFRJ, Brasilian Simulat Ctr, McLeod Inst Technol & Interoperable Modeling & Simulat, Genoa Ctr, McLeod Modeling & Simulat Network, Latvian Simulat Soc, Ecole Superieure Ingn Sci Appliquees, Fac Ciencias Exactas, Ingn & Agrimensura, Univ La Laguna, CIFASIS CONICET UNR UPCAM, Inst Syst & Technologies Informat, Control & Commun, Natl Russian Simulat Soc, CEA IFAC, IEEE, Cent & S Italy Sect Chapter, CAL TEK SRL, Liotech Ltd, Mast Srl DE adaptive computer-based tutoring; ontology; frameworks; authoring; instruction; assessment AB Tutoring research has been ongoing on since the 1960s and workable computer-based tutoring systems (CBTS) have been around since the early 1980s. Expectations are on the rise for CBTS to be available to the masses in much the same way that human tutoring is available from a variety of sources today. A limiting factor in the widespread use of CBTS is the cost to: author tutoring systems; author/deliver domain-specific instructional content; and assess the effectiveness of CBTS tools and methods. A structural framework to represent knowledge within the CBTS domain would enhance reuse and streamline processes making them easier to author on production line scale, and opening the entry point for CBTS to non-computer scientists. This paper considers the benefits and challenges in developing an ontology for a Generalized Intelligent Framework for Tutors (GIFT) to support the development of authoring, instructional and assessment standards and tools for CBTS. C1 [Sottilare, Robert A.] US Army Res Lab, Human Res & Engn Directorate, Learning Intelligent Tutoring Environm LITE Lab, Adelphi, MD 20783 USA. RP Sottilare, RA (reprint author), US Army Res Lab, Human Res & Engn Directorate, Learning Intelligent Tutoring Environm LITE Lab, Adelphi, MD 20783 USA. EM robert.sottilare@us.army.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU DIME UNIV GENOA PI GENOVA PA VIA OPERA PLA, 15-15A, GENOVA, 16145, ITALY BN 978-88-97999-00-3; 978-88-97999-08-9 PY 2012 BP 19 EP 25 PG 7 WC Operations Research & Management Science SC Operations Research & Management Science GA BG9CX UT WOS:000393065300004 ER PT J AU Poovey, AG Mudge, CR Thum, RA James, C Getsinger, KD AF Poovey, Angela G. Mudge, C. R. Thum, R. A. James, C. Getsinger, K. D. TI Evaluations of contact aquatic herbicides for controlling two populations of submersed flowering rush SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE Butomus umbellatus; diquat; endothall; flumioxazin; triploid AB Flowering rush (Butomus umbellatus L.) is a rapidly spreading invasive aquatic plant in the northern United States. Introduced from Eurasia, it grows as an emergent plant along shorelines and as a submersed plant in deeper water of lakes and rivers. Because submersed flowering rush grows in fluctuating water levels, management of this plant has been inconsistent and unpredictable. Two small-scale experiments were conducted to evaluate contact herbicide efficacy on the submersed form of flowering rush from two triploid populations, one from Minnesota and one from Idaho. In the first experiment, various concentrations and exposure times of diquat, endothall, and flumioxazin were applied to Minnesota flowering rush. In the second experiment, concentration exposure time relationships were investigated for flumioxazin against Idaho flowering rush. One treatment of endothall was used to compare flumioxazin, a newly registered compound, with an older chemistry'. Results of both experiments showed that contact herbicides are effective against flowering rush. Although flumioxazin (200 mu g ai L-1) did not significantly reduce shoot biomass for exposure periods of 12 or 24 h, concentrations of diquat (370 mu g ai L-1) for exposure times of 6 and 12 h, and endothall (1500 and 3000 mu g ai L-1) for exposure times of 12 and 24 h reduced shoot biomass of Minnesota submersed flowering rush by >70%; however, these treatments did not significantly impact root biomass. Lateral rhizome buds, which serve as a source of annual reinfestation, were found in all treatments. Concentrations of flurnioxazin (400 mu g ai L-1) and endothall (3000 mu g ai L-1) for exposure times of 24 h controlled Idaho submersed flowering rush by successfully reducing shoot and root biomass by >70%. Application strategies for complete control of triploid flowering rush shoots and roots with contact herbicides may require repeat applications and/or combinations with each other and systemic herbicides. Further evaluation of herbicides for controlling triploid as well as diploid flowering rush is warranted. C1 [Poovey, Angela G.; Mudge, C. R.; Getsinger, K. D.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Thum, R. A.; James, C.] Grand Valley State Univ, Muskegon, MI 49441 USA. RP Poovey, AG (reprint author), US Army Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Angela.G.Poovey@usace.army.mil FU Pelican River Watershed District; US Army Engineer Seattle District; Aquatic Ecosystem Restoration Foundation FX Support and cooperation for this work were provided by the Pelican River Watershed District, the US Army Engineer Seattle District, and the Aquatic Ecosystem Restoration Foundation. Special thanks are extended to Michelle Marko (Concordia College) and Betsy Hull (Albeni Falls Project, US Army Engineer Seattle District) for rhizome collections and to Kate Wilson (Pend Oreille Basin Commission) for information on rhizome sprouting. John Madsen (Mississippi State University) and provided advice on laboratory culture and flowering rush growth requirements. Mike Netherland and John Skogerboe kindly provided technical assistance and reviewed earlier versions of this manuscript. Additional support was provided by Craig Brengle (Albeni Falls Project, US Army Engineer Seattle District) and Tera Guetter (Pelican River Watershed District). Permission was granted by the Chief of Engineers to publish this information. Citation of trade names does not constitute an official endorsement or approval of the use of such commercial products. NR 22 TC 7 Z9 7 U1 0 U2 10 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2012 VL 50 BP 48 EP 54 PG 7 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UL UT WOS:000209043600007 ER PT J AU Glomski, LM Netherland, MD AF Glomski, Leeann M. Netherland, Michael D. TI Does hydrilla grow an inch per day? Measuring short-term changes in shoot length to describe invasive potential SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Glomski, Leeann M.] US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. [Netherland, Michael D.] Ctr Aquat & Invas Plants, US Army Engineer Res & Dev Ctr, Gainesville, FL 32653 USA. RP Glomski, LM (reprint author), US Army Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM LeeAnn.M.Glomski@usace.army.mil FU US Army Engineer Research and Development Center Aquatic Plant Control Research Program; Environmental Protection Agency as part of the Osceola County Demonstration Project on Hydrilla and Hygrophila in the Upper Kissimmee Chain of Lakes, FL (EPA) [X796433105]; Florida Fish and Wildlife Commission, Bureau of Invasive Plant Management FX Support and funding for this project was provided by the US Army Engineer Research and Development Center Aquatic Plant Control Research Program, the Environmental Protection Agency as part of the Osceola County Demonstration Project on Hydrilla and Hygrophila in the Upper Kissimmee Chain of Lakes, FL (EPA Grant ID: X796433105), and the Florida Fish and Wildlife Commission, Bureau of Invasive Plant Management. Permission was granted by the Chief of Engineers to publish this research. The authors would like to thank Kerstin Hoesel and Scott Western for technical assistance. NR 17 TC 4 Z9 4 U1 0 U2 4 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2012 VL 50 BP 54 EP 57 PG 4 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UL UT WOS:000209043600008 ER PT J AU Owens, CS Smart, RM Dick, GO AF Owens, Chetta S. Smart, R. Michael Dick, Gary O. TI Tuber and turion dynamics in monoecious and dioecious hydrilla (Hydrilla verticillata) SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Owens, Chetta S.; Smart, R. Michael; Dick, Gary O.] USAE Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. RP Owens, CS (reprint author), USAE Lewisville Aquat Ecosyst Res Facil, 201 Jones St, Lewisville, TX 75057 USA. EM chetta@laerf.org NR 29 TC 4 Z9 4 U1 1 U2 2 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2012 VL 50 BP 58 EP 62 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UL UT WOS:000209043600009 ER PT J AU Harms, NE Shearer, JF Grodowitz, MJ AF Harms, Nathan E. Shearer, Judy F. Grodowitz, Michael J. TI Natural enemies of floating marshpennywort (Hydrocotyle ranunculoides L.f) in the southern United States SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article C1 [Harms, Nathan E.; Shearer, Judy F.; Grodowitz, Michael J.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Harms, NE (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Nathan.E.Harms@usace.army.mil NR 52 TC 0 Z9 0 U1 1 U2 1 PU AQUATIC PLANT MANAGEMENT SOC, INC PI VICKSBURG PA PO BOX 821265, VICKSBURG, MS 39182 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JAN PY 2012 VL 50 BP 63 EP 68 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA V33UL UT WOS:000209043600010 ER PT B AU Taylor, PJ AF Taylor, Patrick J. BE Rowe, DM TI Thermoelectric Materials, Measurements, and Opportunities for Energy Harvesting SO MATERIALS, PREPARATION, AND CHARACTERIZATION IN THERMOELECTRICS SE Thermoelectrics and its Energy Harvesting LA English DT Article; Book Chapter ID THERMAL-CONDUCTIVITY; ELECTRICAL-PROPERTIES; SUPERLATTICES; DEVICES C1 US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Taylor, PJ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-7471-4; 978-1-4398-7470-7 J9 THERMOELECT ENERG PY 2012 BP T1 EP T12 PG 12 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA BC5UH UT WOS:000353577300021 ER PT B AU Burns, JW Wade, CE AF Burns, John W. Wade, Charles E. BE McAnulty, PA Dayan, AD Ganderup, NC Hastings, KL TI Hemorrhage and Resuscitation Models Using the Miniature Swine SO MINIPIG IN BIOMEDICAL RESEARCH LA English DT Article; Book Chapter ID BOVINE POLYMERIZED HEMOGLOBIN; HYPERTONIC SALINE DEXTRAN; SEVERE UNCONTROLLED HEMORRHAGE; OXYGEN CARRIER RESUSCITATION; OTHERWISE FATAL HEMORRHAGE; FIXED-VOLUME HEMORRHAGE; RECOMBINANT FACTOR VIIA; ACID-BASE STATUS; CONSCIOUS SWINE; DELAYED EVACUATION C1 [Burns, John W.; Wade, Charles E.] US Army Inst Surg Res, Houston, TX 78234 USA. RP Burns, JW (reprint author), US Army Inst Surg Res, Houston, TX 78234 USA. NR 72 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-1119-1; 978-1-4398-1118-4 PY 2012 BP 479 EP 489 PG 11 WC Medicine, Research & Experimental; Veterinary Sciences SC Research & Experimental Medicine; Veterinary Sciences GA BC6GS UT WOS:000353913300033 ER PT B AU Hulet, SW Moroni, M Whitnall, MH Mioduszewski, RJ AF Hulet, Stanley W. Moroni, Maria Whitnall, Mark H. Mioduszewski, Robert J. BE McAnulty, PA Dayan, AD Ganderup, NC Hastings, KL TI The Minipig in Chemical, Biological, and Radiological Research SO MINIPIG IN BIOMEDICAL RESEARCH LA English DT Article; Book Chapter ID SUS-SCROFA-DOMESTICA; BONE-MARROW-TRANSPLANTATION; LASER-RADIATION PULSES; PIG PAROTID-GLANDS; LARGE-ANIMAL-MODEL; MINIATURE PIG; GOTTINGEN MINIPIG; MASS-SPECTROMETRY; VAPOR EXPOSURE; SULFUR MUSTARD C1 [Hulet, Stanley W.; Mioduszewski, Robert J.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21040 USA. [Moroni, Maria; Whitnall, Mark H.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Bethesda, MD 20814 USA. RP Hulet, SW (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21040 USA. NR 110 TC 1 Z9 1 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-1119-1; 978-1-4398-1118-4 PY 2012 BP 533 EP 547 PG 15 WC Medicine, Research & Experimental; Veterinary Sciences SC Research & Experimental Medicine; Veterinary Sciences GA BC6GS UT WOS:000353913300037 ER PT B AU Poda, AR Kennedy, AJ Bednar, AJ AF Poda, A. R. Kennedy, A. J. Bednar, A. J. BE Laudon, M Romanowicz, B TI The Effect of Photolysis on the Stability and Toxicity of Silver Nanoparticles SO NANOTECHNOLOGY 2012, VOL 3: BIO SENSORS, INSTRUMENTS, MEDICAL, ENVIRONMENT AND ENERGY LA English DT Proceedings Paper CT NSTI Nanotechnology Conference and Expo (Nanotech 2012) CY JUN 18-21, 2012 CL Santa Clara, CA SP ACCT Canada, Anaheim Ctr New Energy Technol, Angel Capital Assoc, Antenna Syst Magazine, Appl Mat, Arsenal Venture Partners, Austin Energy, AUTM, BASF, Battery Power Magazine, Carbon Credit Capital, CHInano2011, Clean Technol & Sustainable Ind, Org CTSI, Circuits Multi Projets, Constellat Energy, Eco Business com, EcoSeed, European Patent Off, Fraunhofer TechBridge, GigaOM, Green Blog Network, Greenberg Traurig, Hitachi High Technol Am Inc, Inst Civil Engineers, Insight InterAsia, IOP Publish, Jackson Walker LLP, Japan Technol Grp, Kauffman Fdn, Lam Res Corp, Licens Execut Soc, Lux Res, Mead Westvaco, MEMS Ind Grp, Nano Sci & Technol Inst, nano tech Japan, Natl Grid, Natl Venture Capital Assoc, Nanotechnol Ind Assoc, NE Utilities, PPG Ind, SciTech Patent Art, Shell GameChanger, SK Innovat, So California Edison, Taylor & Francis Grp LLC - CRC Press, TechConnect, Texas Nanotechnol Initiat, Env Business Cluster, Natl Assoc Seed & Venture, Funds NASVF, Zyvex Technol DE silver nanoparticles; photolysis; Daphnia magna; field flow fractionation; dissolved organic carbon AB This work investigates the effect of UV irradiation on the aggregation kinetics and toxicity of a 50 nm silver nanoparticle (AgNP) capped with two different stabilization agents (polyvinylpyrrolidone (PVP) and citrate). The particles were exposed to simulated sunlight by long wave ultra violet light (UVA) irradiation. The impact of the irradiation was investigated in solutions with and without 4 mg/L DOC. Field flow fractionation interfaced to inductively coupled plasma mass spectrometry (FFF-ICP-MS), provided a method to determine size and elemental composition of nanoparticles at environmentally relevant concentrations (parts-per-billion, mu g/L). For PVP coated silver nanoparticles in the presence of DOC, photolysis appeared to create small nanoparticles as represented by growth in the void peak. Regardless of the stabilization coating, the standard zooplankton model, Daphnia magna, indicated that the toxicity of nanosilver was significantly reduced when exposed to UV light and was further reduced when exposed to UV light in the presence of DOC. C1 [Poda, A. R.; Kennedy, A. J.; Bednar, A. J.] US Army Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Road, Vicksburg, MS 39180 USA. RP Poda, AR (reprint author), US Army Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Road, Vicksburg, MS 39180 USA. EM Aimee.r.poda@usace.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4665-6276-9 PY 2012 BP 319 EP 322 PG 4 WC Energy & Fuels; Engineering, Biomedical; Nanoscience & Nanotechnology; Toxicology SC Energy & Fuels; Engineering; Science & Technology - Other Topics; Toxicology GA BG7DZ UT WOS:000391249300082 ER PT B AU Holthoff, EL Pellegrino, PM AF Holthoff, Ellen L. Pellegrino, Paul M. BE Iniewski, K TI Sensing Applications Using Photoacoustic Spectroscopy SO OPTICAL, ACOUSTIC, MAGNETIC, AND MECHANICAL SENSOR TECHNOLOGIES SE Devices Circuits and Systems LA English DT Article; Book Chapter ID QUANTUM-CASCADE LASER; TRACE GAS-ANALYSIS; PHOTO-ACOUSTIC SPECTROSCOPY; DFB DIODE-LASER; MU-M; OPTOACOUSTIC SPECTROSCOPY; HIGH-SENSITIVITY; CHEMICAL SENSOR; CARBON-DIOXIDE; NITRIC-OXIDE C1 [Holthoff, Ellen L.; Pellegrino, Paul M.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Holthoff, EL (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. NR 174 TC 3 Z9 3 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-6978-9; 978-1-4398-6975-8 J9 DEVICE CIRC SYST PY 2012 BP 139 EP 174 PG 36 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BC8AS UT WOS:000355478800007 ER PT B AU Shelby, W Dietz, JE Black, DR AF Shelby, Will Dietz, J. Eric Black, David R. BE Dietz, JE Black, DR TI Classic Military War Principles Applied to Pandemic Preparation SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE Influenza; Pandemic Influenza; Sun Tzu; Carl von Clausewitz; H1N1 Influenza A; Military Principles; Strategic Planning ID INFLUENZA AB Sun Tzu and Carl von Clausewitz, as two classical developers of military theory, provide insights into the challenges of "fighting" pandemic influenza. Sun Tzu's The Art of War was written as early as the sixth century BC and Clausewitz wrote his book in the nineteenth century (Giles 2007; Howard and Paret 1984). Yet these books and the principles described are still applicable to modern military tactics as well as to a host of other disciplines. A novel strain of H1N1 Influenza A caused concern worldwide in 2009. Many countries took precautions, but most could improve their pandemic preparation. An exploration of military principles and application could uncover new methods to establish priorities for the public health and increase efficiency by reducing demands on resources and managing shortages. This chapter attempts to develop principles based on classical military strategy that support planning success for pandemic influenza and the amelioration of disaster preparedness operations by formally recognizing parallels to the military and incorporating concepts and terms. C1 [Shelby, Will] Phi Alpha Theta, Orlando, FL USA. [Dietz, J. Eric] Purdue Univ, Comp & Informat Technol, W Lafayette, IN 47907 USA. [Dietz, J. Eric] Purdues Discovery Pk, W Lafayette, IN USA. [Dietz, J. Eric] Indiana Dept Homeland Secur, Indianapolis, IN USA. [Dietz, J. Eric] Indiana Intelligence Fus Ctr, Indianapolis, IN USA. [Dietz, J. Eric] US Army, Washington, DC USA. [Black, David R.] Purdue Univ, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Publ Hlth, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Homeland Secur Inst, W Lafayette, IN 47907 USA. [Black, David R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Coll Pharm, Commun Skills & Stat, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Prevent & Stress Med, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Psychol, Omaha, NE USA. [Black, David R.] Indiana Mil Acad, Howe, IN USA. RP Shelby, W (reprint author), Phi Alpha Theta, Orlando, FL USA. NR 38 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 35 EP 53 D2 10.1201/b11779 PG 19 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100004 ER PT B AU Branum, A Dietz, JE Black, DR AF Branum, Andrew Dietz, J. Eric Black, David R. BE Dietz, JE Black, DR TI Local Leadership in Pandemic Influenza SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE H1N1; Incident Command System; Leadership; Public Health; Emergency Response; Pandemic Influenza ID PREPAREDNESS AB This chapter focuses on the lessons learned from two statewide pandemic influenza exercises conducted for the State of Indiana in 2008 and 2009 by the Purdue Homeland Security Institute. It discusses those lessons learned under the framework of the importance of local leadership in emergency response during pandemic influenza. The exercises tested various organizations and their levels of preparedness and response, while leaders from local law enforcement, emergency management, public health, and hospital administration gathered to exercise their existing emergency plans. In 2008, the scope of the test included all county and local response teams statewide. The most important lesson learned pertained to the organizational structure of leadership and the design and staffing of a county's incident command influenced the level of effectiveness during the exercise activities. In 2009, hospitals and healthcare facilities participated in tabletop exercises focused on a response to high levels of at-need patients and the ability to implement altered standards of care. Aspects important to success were staff education, problem solving, and for all leaders to be present during the planning stages to prepare for the actual response. An important finding in both exercises was that local leaders do need to be involved in the planning and preparedness part of emergency response, which is contrary to the premise that local emergency management is the most crucial aspect to emergency response. Local leadership continues to be a key aspect of response effectiveness. C1 [Branum, Andrew] Booz Allen Hamilton, Mclean, VA USA. [Branum, Andrew] State Emergency Operat Ctr, Indiana Dept Homeland Secur Projects, Tallahassee, FL USA. [Branum, Andrew; Dietz, J. Eric; Black, David R.] PHSI, Hyderabad, Andhra Pradesh, India. [Dietz, J. Eric] Purdue Univ, Comp & Informat Technol, W Lafayette, IN 47907 USA. [Dietz, J. Eric] Purdues Discovery Pk, Indianapolis, IN USA. [Dietz, J. Eric] Indiana Dept Homeland Secur, Indianapolis, IN USA. [Dietz, J. Eric] Indiana Intelligence Fus Ctr, Indianapolis, IN USA. [Dietz, J. Eric] US Army, Washington, DC USA. [Black, David R.] Purdue Univ, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Publ Hlth, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Homeland Secur Inst, W Lafayette, IN 47907 USA. [Black, David R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Coll Pharm, Commun Skills & Stat, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Prevent & Stress Med, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Psychol, Omaha, NE USA. [Black, David R.] Indiana Mil Acad, Howe, IN USA. RP Branum, A (reprint author), Booz Allen Hamilton, Dept Homeland Secur, Mclean, VA 22102 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 55 EP 64 D2 10.1201/b11779 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100005 ER PT B AU Foley, WA AF Foley, William A., Jr. BE Dietz, JE Black, DR TI Developing a Systematic Pandemic Influenza Program for Preparing a State SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE Pandemic Planning; Preparedness; State Level; Homeland Security AB From a planning perspective, this chapter discusses how to effectively mitigate the spread of an extensive viral infection on a large scale, which requires timely, sensible, and highly sound planning. The focus is on state level planning under the federal model for developing good operational plans. The chapter clarifies terminology, such as "epidemic" rather than "pandemic," as the preferred term for a local or state response. However, after that is explained, "pandemic," which is the common and more frequently used name and in the chapter's title, is referenced thereafter in quotation marks. After the introduction, this study presents a brief history of "pandemic influenza," how a state prepares to develop a plan, agreements and trigger points which must be decided, the planning process itself, the operational plan with its important template for local use, and conclusions. Tracing a common operating picture from the federal, to the state, and to the city/county levels for "pandemic influenza," planning is the first theme. How to incorporate continuity of government and continuity of operations into a plan, in the face of a rapidly spreading "pandemic," is the second one. Last, how to deliver from the state to the county level, one workable document called an Operational Plan (OPLAN) with a county template for local use, is the last theme. That template gives counties a "pandemic influenza" model for planning that is the same as states and regions use, which they can directly apply locally. Thus this planning process saves lives during a "pandemic." C1 [Foley, William A., Jr.] Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA. [Foley, William A., Jr.] US Dept Homeland Secur DHS, NLE, Washington, DC USA. [Foley, William A., Jr.] IDHS, Indianapolis, IN USA. [Foley, William A., Jr.] Ardent Sentry Northern Edge, Peterson AFB, CO USA. [Foley, William A., Jr.] US Army War Coll, Strateg Leadership, Carlisle, PA USA. [Foley, William A., Jr.] US Army Forces Command FORSCOM, Homeland Secur, Ft Bragg, NC USA. [Foley, William A., Jr.] WMD Branch, New York, NY USA. US Northern Command NORTHCOM, Joint Forces Land Component Command JFLCC FORSCOM, Colorado Springs, CO USA. [Foley, William A., Jr.] US Army, Washington, DC USA. RP Foley, WA (reprint author), Indiana Univ, Sch Publ & Environm Affairs, Bloomington, IN 47405 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 65 EP 94 D2 10.1201/b11779 PG 30 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100006 ER PT B AU Dietz, JE Chaturvedi, AR Black, DR Shaffner, JE Hsieh, CH Dunlop, S Leonard, KE Burr, JF AF Dietz, J. Eric Chaturvedi, Alok R. Black, David R. Shaffner, Julie E. Hsieh, Chih-hui Dunlop, Steven Leonard, Kara E. Burr, John F. BE Dietz, JE Black, DR TI Developing a Prevention and Control Program with an Accompanying Simulation SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE Influenza; Preparedness; Simulation Modeling; Synthetic Environment; Analysis and Simulation ID INFLUENZA; ABSENTEEISM; MODEL AB Pandemic preparedness training for schools* is an evidence-based influenza prevention program. The purpose of this project was to provide an assessment of how policies, behaviors, and the environment might affect transmission of an influenza virus within a school. Following a thorough assessment of the school, specific recommendations for improvement are provided. The results of the assessment are enhanced by a "game-like" simulation of the spread of the virus through the school, providing a visual representation of how students and staff might be affected by an influenza virus. This preparedness exercise has many potential benefits for schools, such as providing knowledge to mitigate the impact of the flu, keeping students and staff healthy, building social capital by implementing programs directly related to the safety of the students, and reinforcing policy and preventive health training which reduces disease transmission. The simulation applied for this program can model the relevant geographic areas with all the relevant features (schools, hospitals, railways, airports, lakes, rivers, and business districts) to create an artificial virtual community. These virtual geographies can be customized to mimic real geographies from outbreaks to pandemics. C1 [Dietz, J. Eric; Chaturvedi, Alok R.; Shaffner, Julie E.; Leonard, Kara E.] Purdue Homeland Secur Inst, W Lafayette, IN 47907 USA. [Dietz, J. Eric; Burr, John F.] Purdue Univ, W Lafayette, IN 47907 USA. [Dietz, J. Eric; Burr, John F.] Purdues Discovery Pk, W Lafayette, IN USA. [Dietz, J. Eric] Indiana Dept Homeland Secur, W Lafayette, IN USA. [Dietz, J. Eric] Governors Counterterrorism & Secur Council, Chicago, IL USA. [Dietz, J. Eric] Indiana Intelligence Fus Ctr, Format, Indianapolis, IN USA. [Dietz, J. Eric] US Army, Washington, DC USA. [Chaturvedi, Alok R.] Purdue Univ, Krannert Grad Sch Management, W Lafayette, IN 47907 USA. [Chaturvedi, Alok R.] Simulex Inc, W Lafayette, IN USA. [Chaturvedi, Alok R.] US Dept Def, Sentient World Simulat Project, Washington, DC USA. [Chaturvedi, Alok R.] Indianas Dept Educ & Family & Social Serv Adm FSS, W Lafayette, IN USA. [Chaturvedi, Alok R.] Def Acquisit Univ, Off Naval Res, Indiana 21st Century Res & Technol Fund, Natl Sci Fdn, Ft Belvoir, VA USA. [Shaffner, Julie E.] ICAAP, Obes Prevent Initiat, Bangkok, Thailand. [Shaffner, Julie E.] ICAAP, Bangkok, Thailand. [Hsieh, Chih-hui] Purdue Univ, Krannert Sch Management, SEAS Lab, W Lafayette, IN 47907 USA. [Hsieh, Chih-hui] SEAS, London, England. [Dunlop, Steven] Indiana Adv Elect Vehicle Training Consortium, Notre Dame, IN USA. [Dunlop, Steven] Envis Ctr Data Perceptualizat, W Lafayette, IN USA. [Dunlop, Steven] Coll Technol, London, England. [Dunlop, Steven; Burr, John F.] Purdue, W Lafayette, IN USA. [Burr, John F.] Purdue Univ, Krannert Sch Management, W Lafayette, IN 47907 USA. [Burr, John F.] DuPont Co Inc, Eleutherian Mills, DE USA. [Burr, John F.] Corian Div, Newark, DE USA. RP Dietz, JE (reprint author), Purdue Homeland Secur Inst, W Lafayette, IN 47907 USA. NR 40 TC 0 Z9 0 U1 0 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 107 EP 121 D2 10.1201/b11779 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100008 ER PT B AU Shaffner, JE Black, DR Dietz, JE AF Shaffner, Julia E. Black, David R. Dietz, J. Eric BE Dietz, JE Black, DR TI The Future of Survey-Based Research: Exploring University Students' Vaccination Decisions SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE Pandemic Preparedness; Survey-Based Research; Influenza Vaccination; Health Belief Model ID IMMUNIZATION; MEASLES; ACCEPTANCE; BARRIERS; MUMPS AB This study was undertaken to compare university students who received the 2009 H1N1 influenza vaccination versus those who did not. This was prompted by the Centers for Disease Control and Prevention's declaration that individuals under the age of 24 were at risk for contracting this novel strain of influenza. The comparison between the immunized and non-immunized students was made in terms of gender, academic year, academic department, nationality, and the six constructs of the health belief model: perceived susceptibility, perceived severity, perceived benefits, perceived barriers, cues to action, and self efficacy. An e-mail with a hyperlink to an online survey was sent to 4,000 university students. The online influenza vaccination questionnaire was based on adapted questions from two earlier surveys. Construct validity was established through expert review of the survey items. Response bias, clarity, and readability were assessed by review and feedback from 30 individuals. Reading ease and grade level were assessed by the Flesch and Flesch-Kincaid tests. Principal components analysis was used to reduce the items used for further analyses, and to ensure that any survey items used loaded on just one theoretical construct. Backward stepwise logistic regression analyses showed the following variables were significantly related (p < 0.05) to immunization: cues to action, perceived barriers, and perceived benefits. Characteristics of the vaccination played a role in the decision, while the characteristics of the disease itself did not. This finding has implications for the development and implementation of future vaccination campaigns targeted at specific segments of the population. C1 [Shaffner, Julia E.] ICAAP, Obes Prevent Initiat, Dhaka, Bangladesh. [Shaffner, Julia E.] ICAAP, Dhaka, Bangladesh. [Shaffner, Julia E.; Black, David R.; Dietz, J. Eric] PHSI, London, England. [Black, David R.; Dietz, J. Eric] Purdue Univ, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Publ Hlth, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Homeland Secur Inst, W Lafayette, IN 47907 USA. [Black, David R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Coll Pharm, Commun Skills & Stat, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Prevent & Stress Med, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Psychol, Omaha, NE USA. [Black, David R.] Indiana Mil Acad, Howe, IN USA. [Dietz, J. Eric] Purdues Discovery Pk, W Lafayette, IN USA. [Dietz, J. Eric] Indiana Dept Homeland Secur, Auburn, IN USA. [Dietz, J. Eric] Governors Counterterrorism & Secur Council, Washington, DC USA. [Dietz, J. Eric] Indiana Intelligence Fus Ctr, W Lafayette, IN USA. [Dietz, J. Eric] US Army, Washington, DC USA. RP Shaffner, JE (reprint author), ICAAP, Obes Prevent Initiat, Dhaka, Bangladesh. NR 32 TC 0 Z9 0 U1 2 U2 2 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 165 EP 182 D2 10.1201/b11779 PG 18 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100012 ER PT B AU Smock, JA Black, DR Dietz, JE AF Smock, Jennifer A. Black, David R. Dietz, J. Eric BE Dietz, JE Black, DR TI A Demonstration of Social Media Research Methods: Investigating the Public Opinion of the Flu Shot during the H1N1 Pandemic SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE H1N1; Pandemic Influenza; Twitter; Social Media; Radian(6); Agenda-Setting Theory; Heuristic Demonstration of Social Media Research Methods: Investigating Public Opinion of the Flu Shot during the H1N1 Pandemic ID ORGAN DONATION; ATTITUDES; TRUST; WILL AB This chapter is a demonstration of novel research methods used to investigate the public opinion through analysis of Twitter mentions on health topics. This study presents an alternative to current research methods of assimilating focus groups, constructing survey instruments, and disseminating surveys in order to evaluate the public opinion. The methods proposed drastically decrease the lag time of the several months recommended between news media coverage on a specific topic and a survey to gain the public opinion relating to that topic (Eyal 1979; Eyal 1981; Stone and McCombs 1981). The robust marketing technology, Radian(6), was used to gather Internet mentions and perform automated sentiment analyses to the health topic mentions. This automated monitoring and analyses of topic mentions greatly reduces non-response bias, response bias, survey instrumentation error, and biased analyses by investigators. Although this technology has not yet been applied to public health research, it is currently being utilized by multiple Fortune 500 companies (e.g., Pepsi, IBM, Microsoft, General Electric, and Johnson & Johnson). By using Radian6 and the novel research methods, the public opinion can be observed and analyzed in real time. C1 [Smock, Jennifer A.] Natl Assoc Cty & City Officials, Washington, DC 20036 USA. [Smock, Jennifer A.] Natl Assoc Cty & City Officials NACCHO, PPHR, Washington, DC USA. [Smock, Jennifer A.] NACCHO, Washington, DC USA. [Smock, Jennifer A.; Black, David R.; Dietz, J. Eric] PHSI, London, England. [Smock, Jennifer A.] Purdue Campus Emergency Preparedness & Planning O, W Lafayette, IN USA. [Black, David R.; Dietz, J. Eric] Purdue Univ, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Publ Hlth, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Homeland Secur Inst, W Lafayette, IN 47907 USA. [Black, David R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Coll Pharm, Commun Skills & Stat, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Prevent & Stress Med, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Psychol, Omaha, NE USA. [Black, David R.] Indiana Mil Acad, Howe, IN USA. [Dietz, J. Eric] Purdues Discovery Pk, W Lafayette, IN USA. [Dietz, J. Eric] Indiana Dept Homeland Secur, Auburn, IN USA. [Dietz, J. Eric] Governors Counterterrorism & Secur Council, Indianapolis, IN USA. [Dietz, J. Eric] Indiana Intelligence Fus Ctr, Indianapolis, IN USA. [Dietz, J. Eric] US Army, Washington, DC USA. RP Smock, JA (reprint author), Natl Assoc Cty & City Officials, Washington, DC 20036 USA. NR 24 TC 0 Z9 0 U1 3 U2 3 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 183 EP 197 D2 10.1201/b11779 PG 15 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100013 ER PT B AU Hankins, D Burns, M Kuhlman, P Baldwin, T Smock, JA Bynum, A Shaffner, JE Dietz, JE Black, DR AF Hankins, David Burns, Marti Kuhlman, Pat Baldwin, Tim Smock, Jennifer A. Bynum, Andrew Shaffner, Julie E. Dietz, J. Eric Black, David R. BE Dietz, JE Black, DR TI Lessons Learned from Tabletop Exercises SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE Pandemic Influenza; Essential Services; Exercise Planning; Tabletop Exercises; Functional Exercises AB This chapter provides information regarding development and delivery of pandemic influenza preparedness exercises for Indiana rural hospitals and their partner stakeholders between 2008 and 2010. In 2008, functional exercises were delivered across the state using a web-based system that was supported by video, e-mail, phone, and fax. This approach allowed us to remain at Purdue University, yet communicate with and deliver the exercise to players who largely remained at their respective work stations within their counties to participate in the exercise. Worksheets were included with each inject with more than half required to be returned. Returned worksheets allowed us to ensure that participants were engaged and helped measure their success or identify areas that needed improvement. In 2009 and 2010, we developed tabletop exercises that were delivered on-site to nine counties in five of the Indiana homeland security districts. Again, these were primarily aimed at rural hospitals and their stakeholders. In this series of exercises, the spotlight was aimed at identifying those essential services that hospitals/communities wanted to retain despite the challenges of an influenza pandemic. In other words, it required players to determine what they would stop or alter in order to continue providing what they had identified as their "essential services." The chapter concludes with some tips that may be valuable for those new to exercise planning. C1 [Hankins, David] Purdue Univ, PHSI, W Lafayette, IN 47907 USA. [Hankins, David] US Air Force, Washington, DC USA. [Hankins, David] Purdue Homeland Secur Inst PHSI Team, W Lafayette, IN USA. [Hankins, David] Indiana State Dept Hlth ISDH Hlth Preparedness &, PHSI Efforts, W Lafayette, IN USA. [Burns, Marti] Purdue Univ, Visual Analyt Command Control & Interoperabil Env, Engagement & Educ, W Lafayette, IN 47907 USA. [Burns, Marti; Kuhlman, Pat; Baldwin, Tim; Smock, Jennifer A.; Shaffner, Julie E.; Dietz, J. Eric; Black, David R.] PHSI, London, England. [Kuhlman, Pat] Weas Engn, Tech Dept, Westfield, IN USA. [Kuhlman, Pat] Weas Engn, Westfield, IN USA. [Baldwin, Tim] Westminster Inst, Counterterrorism Training & Res, Washington, DC USA. [Baldwin, Tim] Purdue Off Planning & Preparedness, W Lafayette, IN USA. [Smock, Jennifer A.] Natl Assoc Cty & City Officials, Washington, DC USA. [Smock, Jennifer A.] Natl Assoc Cty & City Officials NACCHO, PPHR, Washington, DC USA. [Smock, Jennifer A.] NACCHO, Washington, DC USA. [Smock, Jennifer A.] Purdue Campus Emergency Preparedness & Planning O, W Lafayette, IN USA. [Shaffner, Julie E.] ICAAP, Obes Prevent Initiat, Dhaka, Bangladesh. [Shaffner, Julie E.] ICAAP, Dhaka, Bangladesh. [Dietz, J. Eric; Black, David R.] Purdue Univ, W Lafayette, IN 47907 USA. [Dietz, J. Eric] Purdues Discovery Pk, W Lafayette, IN USA. [Dietz, J. Eric] Indiana Dept Homeland Secur, W Lafayette, IN USA. [Dietz, J. Eric] Governors Counterterrorism & Secur Council, London, England. [Dietz, J. Eric] Indiana Intelligence Fus Ctr, W Lafayette, IN USA. [Dietz, J. Eric] US Army, Washington, DC USA. [Black, David R.] Purdue Univ, Publ Hlth, W Lafayette, IN 47907 USA. [Black, David R.] Purdue Univ, Homeland Secur Inst, W Lafayette, IN 47907 USA. [Black, David R.] Univ Nebraska Med Ctr, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Coll Pharm, Commun Skills & Stat, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Prevent & Stress Med, Omaha, NE USA. [Black, David R.] Univ Nebraska Med Ctr, Dept Psychol, Omaha, NE USA. [Black, David R.] Indiana Mil Acad, Indianapolis, IN USA. RP Hankins, D (reprint author), Purdue Univ, PHSI, W Lafayette, IN 47907 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 215 EP 233 D2 10.1201/b11779 PG 19 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100015 ER PT B AU Rapp, RR AF Rapp, Randy R. BE Dietz, JE Black, DR TI Recovery Planning for Critical Pandemic-Associated Built Infrastructure SO PANDEMIC PLANNING LA English DT Article; Book Chapter DE Built Infrastructure; Disaster Restoration; Reconstruction; Contingency Planning AB The condition of the infrastructure of medical and other buildings and facilities plays a primary role in supporting the medical activities required to control pandemics. This chapter discusses some of the possible infrastructure damages and requirements that might erupt in conjunction with a pandemic to exacerbate its effect. It recommends planning techniques by which pandemic-associated built infrastructure recovery might be quicker and more thorough. C1 [Rapp, Randy R.] Purdue Univ, Bldg Construct Management Technol, W Lafayette, IN 47907 USA. [Rapp, Randy R.] KBR, Houston, TX USA. [Rapp, Randy R.] Restore Iraqi Oil Program, Baghdad, Iraq. [Rapp, Randy R.] US Army, Washington, DC USA. [Rapp, Randy R.] NATO Logist & Engn, Boston, MA USA. [Rapp, Randy R.] Pentagon R&D & Procurement Prioritizat, New York, NY USA. RP Rapp, RR (reprint author), Purdue Univ, Bldg Construct Management Technol, W Lafayette, IN 47907 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-5767-0; 978-1-4398-5765-6 PY 2012 BP 259 EP 283 D2 10.1201/b11779 PG 25 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8IS UT WOS:000355700100017 ER PT S AU Yin, S Ruffin, P Brantley, C Edwards, E Cheng, JP Luo, C AF Yin, Stuart (Shizhuo) Ruffin, Paul Brantley, Christina Edwards, Eugene Cheng, Jiping Luo, Claire BE Yin, S Guo, R TI High efficiency IR supercontinuum generation and applications (A Recent Review) SO PHOTONIC FIBER AND CRYSTAL DEVICES: ADVANCES IN MATERIALS AND INNOVATIONS IN DEVICE APPLICATIONS VI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Photonic Fiber and Crystal Devices - Advances in Materials and Innovations in Device Applications VI CY AUG 12-13, 2012 CL San Diego, CA SP SPIE DE Supercontinuum; Mid-Infrared (IR); nonlinear fiber optics; chemical analysis; spectral analysis ID CRYSTAL SAPPHIRE FIBERS; POWER AB In this paper, we have reviewed our recent works on IR supercontinuum generation (SCG) and its applications. First, we provide a brief review on the physical mechanism of the supercontinuum generation and our previous works in this field. Second, a thinner IR crystal fiber is fabricated. The supercontinuum generation in this thinner fiber is also demonstrated, which shows the enhanced performance. The suggestion for the future effort is also included. C1 [Yin, Stuart (Shizhuo); Cheng, Jiping] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] US Army Aviat, Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. FU Army SBIR FX Claire Luo acknowledges the partial support from an Army SBIR project. Also, the views expressed herein are those of the author and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U. S. Government." NR 13 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-9214-2 J9 PROC SPIE PY 2012 VL 8497 AR 84970H DI 10.1117/12.932231 PG 5 WC Crystallography; Optics SC Crystallography; Optics GA BCZ61 UT WOS:000312213900012 ER PT B AU Lux, S Foster, C Sellers, M Friedl, A Feickert, C Hesterberg, J Marsh, C AF Lux, Scott Foster, Christopher Sellers, Meredith Friedl, Andrew Feickert, Carl Hesterberg, Justin Marsh, Charles GP ASME TI GENERATIVE TEXTILES FOR NON-ROTARY POWER PRODUCTION FROM WIND SO PROCEEDINGS OF THE ASME 6TH INTERNATIONAL CONFERENCE ON ENERGY SUSTAINABILITY - 2012, PTS A AND B LA English DT Proceedings Paper CT 6th ASME International Conference on Energy Sustainability CY JUL 23-26, 2012 CL San Diego, CA SP ASME, Adv Energy Syst Div, ASME, Solar Energy Div ID STORAGE AB The U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) is developing a new class of flexible, generative textile as a novel means of sustainable wind energy generation. Flexible, generative carbon nanotube (CNT)-based textiles may have excellent potential for electrical capacitive storage and reuse in conjunction with small-scale energy-harvesting systems, both from wind for fixed applications and from human locomotion. This paper describes the design and optimization of a three-layer generative textile composed of discrete layers for generation, distribution, and storage. Initial results suggest that improvement in the generation layer will provide the highest increase in overall performance. The output of the electromagnetic tests shows a power density of 0.17 mW/cm(3). However, the efficiency can be significantly improved through increasing the voltage output of the generation layer from 20 mV to around 1V. In an analysis of the operational envelope, wind data collected locally at ERDC-CERL and at other sites around the world reveal close similarity in the probability distributions, which could allow for a practical engineering approach capable of harvesting the steady "ram" component in addition to a variable energy component of the wind. To further study the textile-wind interactions, a wind simulation environment is being developed and has been able to obtain reproducible wind speed data thus far. C1 [Lux, Scott; Foster, Christopher; Sellers, Meredith; Friedl, Andrew; Feickert, Carl; Hesterberg, Justin; Marsh, Charles] US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Lux, S (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. NR 18 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4481-6 PY 2012 BP 1415 EP 1422 PG 8 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA BA4HE UT WOS:000335710300163 ER PT B AU Slipher, GA Mrozek, RA Shumaker, JL AF Slipher, Geoffrey A. Mrozek, Randy A. Shumaker, Justin L. GP ASME TI TUNABLE BAND-PASS FILTERS EMPLOYING STRETCHABLE ELECTRONIC COMPONENTS SO PROCEEDINGS OF THE ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS, VOL 1 LA English DT Proceedings Paper CT ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems CY SEP 19-21, 2012 CL Stone Mountain, GA SP ASME, Gen Motors, Parker Hannifin, Dynalloy Inc, Teledyne Sci & Imag, IOP Publishing, Sage Publish, NextGen Aeronaut, Natl Sci Fdn, Air Force Off Sci Res AB This paper describes some of the recent results of an ongoing U.S. Army research program examining the electronic behavior of hyperelastic stretchable capacitor, resistor, and inductor networks for which the conductor material employed is stretchable. As with traditional rigid analog components, stretchable electronic components exhibit frequency-dependant behavior. Unlike their rigid counterparts, stretchable electronic components may also exhibit dramatic strain-dependent behavior. In this way stretchable circuit networks may be viewed as controllable spatio-temporal filters. Resistance, capacitance, and inductance all change to varying degrees depending on the specific set of spatio-temporal inputs. These variations may be harnessed to create an adaptive circuit element that is controllable. This paper describes the results of integrating stretchable components into a tunable band-pass filter. Center frequency, bandwidth, and gain can be varied in a controllable way by varying the capacitance or resistance of specific circuit elements by stretching them. Biaxially stretchable components are described that are subjected to equibiaxial strain-states as high as 100% area strain. We examine the influence that the type of compliant conductor has on tunable circuit properties and on control authority. C1 [Slipher, Geoffrey A.; Mrozek, Randy A.; Shumaker, Justin L.] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Slipher, GA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA. RI Slipher, Geoffrey/A-6365-2016 OI Slipher, Geoffrey/0000-0003-0532-0081 NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4509-7 PY 2012 BP 185 EP 192 PG 8 WC Computer Science, Artificial Intelligence; Engineering, Mechanical; Materials Science, Multidisciplinary SC Computer Science; Engineering; Materials Science GA BGX45 UT WOS:000324504000026 ER PT B AU Riddick, JC Hall, AJ Myers, OJ AF Riddick, Jaret C. Hall, Asha J. Myers, Oliver J. GP ASME TI NUMERICAL INVESTIGATION OF THE RESPONSE OF ACTIVE BEND-TWIST PZT ACTUATOR SO PROCEEDINGS OF THE ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS, VOL 1 LA English DT Proceedings Paper CT ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems CY SEP 19-21, 2012 CL Stone Mountain, GA SP ASME, Gen Motors, Parker Hannifin, Dynalloy Inc, Teledyne Sci & Imag, IOP Publishing, Sage Publish, NextGen Aeronaut, Natl Sci Fdn, Air Force Off Sci Res ID BEAMS AB Army combat operations have placed a high premium on reconnaissance missions for micro air vehicles (MAVs). An analysis of insect flight indicates that in addition to the bending excitation (flapping), simultaneous excitation of the twisting degree-of-freedom is required to manipulate the control surface adequately. By adding a layer of angled piezoelectric segments to a Pb(Zr,Ti)O3 (also referred to as PZT) bimorph actuator, a bend-twist coupling may be introduced to the flexural response of the layered PZT, thereby creating a biaxial actuator capable of driving wing oscillation in flapping wing MAVs. The present study presents numerical investigation of the response of functionally modified bimorph designs intended for active bend-twist actuation of cm-scale flapping wing devices. The relationships of geometry and orientation of the angled segments with bimorph bend-twist response will be presented using results of finite-element analyses. C1 [Riddick, Jaret C.; Hall, Asha J.] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Riddick, JC (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4509-7 PY 2012 BP 553 EP 558 PG 6 WC Computer Science, Artificial Intelligence; Engineering, Mechanical; Materials Science, Multidisciplinary SC Computer Science; Engineering; Materials Science GA BGX45 UT WOS:000324504000067 ER PT B AU Ayers, J Weerasooriya, T Ghoshal, A Pecora, C Gunnarsson, A Sanborn, B Turney, P AF Ayers, James Weerasooriya, Tusit Ghoshal, Anindya Pecora, Collin Gunnarsson, Allan Sanborn, Brett Turney, Peter GP ASME TI FEASIBILITY OF STRUCTURAL HEALTH MONITORING OF HIGH STRAIN RATE EVENTS USING FIBER BRAGG GRATING SENSORS SO PROCEEDINGS OF THE ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS, VOL 1 LA English DT Proceedings Paper CT ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems CY SEP 19-21, 2012 CL Stone Mountain, GA SP ASME, Gen Motors, Parker Hannifin, Dynalloy Inc, Teledyne Sci & Imag, IOP Publishing, Sage Publish, NextGen Aeronaut, Natl Sci Fdn, Air Force Off Sci Res AB Strategically located. Fiber Bragg Grating (FBG) Sensors have been proposed as an in situ method to increase the signal to noise ratio (SNR) for metallic and composite components. This paper presents a systematic study that investigates the viability of FBG Sensors under high strain rate loading by initially measuring 1D-strains in a compression Hopkinson bar experiment, followed by 2D full-field strain-tensor in impact and blast experiments on plates. Specifically, high strain rates from commercialized FBG Sensors are compared to traditional resistive and semi-conductor based strain gages under various levels of 1D high strain rate loading. In the projectile-plate impact experiments, full-field back-surface strain measured using FBG Sensor arrays are compared with that measured from 3D surface Digital Image Correlation (3D-sDIC) strain measuring technique. Finally, strains in welded steel plates subjected to high explosive discharge are monitored with mounted FBG Sensors on the back surface. From this study, potential improvements in the SNR of FBG Sensors are recommended, and the survivability of these sensors under more complex, dynamic loading is evaluated. C1 [Ayers, James; Weerasooriya, Tusit; Ghoshal, Anindya; Pecora, Collin; Gunnarsson, Allan] US Army Res Lab, Aberdeen Proving Ground, MD USA. RP Ayers, J (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD USA. NR 22 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4509-7 PY 2012 BP 739 EP 748 PG 10 WC Computer Science, Artificial Intelligence; Engineering, Mechanical; Materials Science, Multidisciplinary SC Computer Science; Engineering; Materials Science GA BGX45 UT WOS:000324504000090 ER PT B AU Ghoshal, A Ayers, J Gurvich, M Urban, M Bordick, N AF Ghoshal, Anindya Ayers, James Gurvich, Mark Urban, Michael Bordick, Nathaniel GP ASME TI EXPERIMENTAL INVESTIGATIONS IN EMBEDDED SENSING FOR STRUCTURAL HEALTH MONITORING OF COMPOSITE COMPONENTS IN AEROSPACE VEHICLES SO PROCEEDINGS OF THE ASME CONFERENCE ON SMART MATERIALS, ADAPTIVE STRUCTURES AND INTELLIGENT SYSTEMS, VOL 1 LA English DT Proceedings Paper CT ASME Conference on Smart Materials, Adaptive Structures and Intelligent Systems CY SEP 19-21, 2012 CL Stone Mountain, GA SP ASME, Gen Motors, Parker Hannifin, Dynalloy Inc, Teledyne Sci & Imag, IOP Publishing, Sage Publish, NextGen Aeronaut, Natl Sci Fdn, Air Force Off Sci Res ID SENSOR AB This paper summarizes the experimental investigations for smart embedded sensing in rotorcraft composite components. The overall objective of this effort was to develop smart embedded sensor technologies for condition based maintenance (CBM) for composite components in Army rotorcraft. This paper presents the results of experimental investigations related to development and maturation of different types of embedded sensing solutions for structural health monitoring of composite components including Fiber Bragg Grating (FBG) sensors, phased and discrete piezoelectric sensor arrays. A discussion is provided relative to embedment of optical fibers into composites, and the results from embedded FBG sensors in a rotorcraft flexbeam subcomponent test specimen with seeded delamination subjected to dynamic loading. Likewise, results are analyzed of surface mounted phased array and embedded smart piezoelectric sensors in the flexbeam subcomponent test specimen with embedded delamination, subjected to fatigue cyclic loading. The paper also summarizes the lessons learned from efforts to nucleate and propagate delamination within composite components under dynamic cyclic loading. C1 [Ghoshal, Anindya; Ayers, James] Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Ghoshal, A (reprint author), Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4509-7 PY 2012 BP 845 EP 854 PG 10 WC Computer Science, Artificial Intelligence; Engineering, Mechanical; Materials Science, Multidisciplinary SC Computer Science; Engineering; Materials Science GA BGX45 UT WOS:000324504000103 ER PT B AU Judge, JA Vignola, JF Glean, AAJ Ryan, TJ Good, CE Gugino, PM Bishop, SS Soumekh, M AF Judge, John A. Vignola, Joseph F. Glean, Aldo A. J. Ryan, Teresa J. Good, Chelsea E. Gugino, Peter M. Bishop, Steven S. Soumekh, Mehrdad GP ASME TI DETECTION OF NON-METALLIC CORDS USING SYNTHETIC APERTURE ACOUSTIC IMAGING SO PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE 2012, VOL 1, PTS A AND B LA English DT Proceedings Paper CT 24th Conference on Mechanical Vibration and Noise CY AUG 12-15, 2012 CL Chicago, IL SP ASME, Design Engn Div, ASME, Comp & Informat Engn Div AB Synthetic aperture acoustic (SAA) imaging is a technique for remotely obtaining information about the location, geometry, and mechanical properties of objects based on the way they scatter incident acoustic energy. Results are presented for an experimental investigation of the use of SAA imaging to detect non-metallic cords of different sizes laid in various configurations on the ground surface in an outdoor urban environment. Interest in this application of SAA stems from the fact that non-metallic cords are not readily detectable with synthetic aperture radar (SAR) and that the SAA imaging approach represents a relatively inexpensive alternative or supplement to SAR. The measurement system is comprised of a mobile acoustic transceiver (a speaker and microphone) that broadcasts a burst chirp with a bandwidth of 2-15 kHz. The recorded signal is used to form a two-dimensional image of the distribution of acoustic scatterers within the scene. For this study, five different diameters (2-15mm) of nylon cord laid on the ground were imaged in different configurations. These measurements were made in the presence of urban ambient noise of varying levels. The goal of this study was to identify the effect of environmental noise and other parameters on detectability. The results demonstrate that non-metallic cords can be detected acoustically if the angle to the transceiver path is sufficiently small. C1 [Judge, John A.; Vignola, Joseph F.; Glean, Aldo A. J.; Ryan, Teresa J.; Good, Chelsea E.] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA. [Gugino, Peter M.; Bishop, Steven S.] US Army, RDECOM CERDEC Night Vis & Elect Sensor Directorat, Belvoir, VA 10221 USA. [Soumekh, Mehrdad] Soumekh Consulting, Bethesda, MD USA. RP Judge, JA (reprint author), Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA. EM judge@cua.edu; vignola@cua.edu; 10glean@cardinalmail.cua.edu; 59woods@cardinalmail.cua.edu; 26good@cardinalmail.cua.edu; msoum@eng.buffalo.edu FU US Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate FX This work was conducted as part of a grant from the Army Research Office and supported by the US Army RDECOM CERDEC Night Vision and Electronic Sensors Directorate. NR 6 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4500-4 PY 2012 BP 265 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA3XW UT WOS:000335091200032 ER PT B AU Melanz, D Khude, N Jayakumar, P Leatherwood, M Negrut, D AF Melanz, Daniel Khude, Naresh Jayakumar, Paramsothy Leatherwood, Mike Negrut, Dan GP ASME TI A GPU Parallelization of the Absolute Nodal Coordinate Formulation for Applications in Flexible Multibody Dynamics SO PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE 2012, VOL 2, PTS A AND B LA English DT Proceedings Paper CT ASME International Design Engineering Technical Conferences/Computers Information in Engineering Conference CY AUG 12-15, 2012 CL Chicago, IL SP ASME, Design Engn Div, ASME, Comp & Informat Engn Div AB The Absolute Nodal Coordinate Formulation (ANCF) has been widely used to carry out the dynamics analysis of flexible bodies that undergo large rotation and large deformation. This formulation is consistent with the nonlinear theory of continuum mechanics and is computationally more efficient compared to other nonlinear finite element formulations. Kinematic constraints that represent mechanical joints and specified motion trajectories can be introduced to make complex flexible mechanisms. As the complexity of a mechanism increases, the system of differential algebraic equations becomes very large and results in a computational bottleneck. This contribution helps alleviate this bottleneck using three tools: (1) an implicit time-stepping algorithm, (2) fine-grained parallel processing on the Graphics Processing Unit (GPU), and (3) enabling parallelism through a novel Constraint-Based Mesh (CBM) approach. The combination of these tools results in a fast solution process, that scales linearly for large numbers of elements, allowing meaningful engineering problems to be solved. C1 [Melanz, Daniel; Khude, Naresh; Negrut, Dan] Univ Wisconsin, Dept Mech Engn, Madison, WI 53706 USA. [Jayakumar, Paramsothy; Leatherwood, Mike] US Army Tank Automot Res Dev, Ctr Engn, Warren, MI 48397 USA. RP Melanz, D (reprint author), Univ Wisconsin, Dept Mech Engn, Madison, WI 53706 USA. NR 6 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4501-1 PY 2012 BP 839 EP + PG 3 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary SC Computer Science; Engineering GA BA4KX UT WOS:000335932700093 ER PT B AU Song, HJ Choi, KK Lee, I Zhao, L Lamb, D AF Song, Hyeongjin Choi, K. K. Lee, Ikjin Zhao, Liang Lamb, David GP ASME TI Sampling-based RBDO using Probabilistic Sensitivity Analysis and Virtual Support Vector Machine SO PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE 2012, VOL 3, PTS A AND B LA English DT Proceedings Paper CT ASME International Design Engineering Technical Conferences/Computers Information in Engineering Conference CY AUG 12-15, 2012 CL Chicago, IL SP ASME, Design Engn Div, ASME, Comp & Informat Engn Div DE Surrogate Model; Sampling-based RBDO; Probabilistic Sensitivity Analysis; Support Vector Machine (SVM); Sequential Sampling; Virtual Samples; Virtual Support Vector Machine (VSVM); Hyper-spherical Local Window ID DESIGN OPTIMIZATION; COMPUTER EXPERIMENTS; MINIMIZATION; INTEGRATION; SEARCH AB In this paper, a sampling-based RBDO method using a classification method is presented. The probabilistic sensitivity analysis is used to compute sensitivities of probabilistic constraints with respect to random variables. Since the probabilistic sensitivity analysis requires only the limit state function, and not the response surface or sensitivity of the response, an efficient classification method can be used for a sampling-based RBDO. The proposed virtual support vector machine (VSVM), which is a classification method, is a support vector machine (SVM) with virtual samples. By introducing virtual samples, VSVM overcomes the deficiency in existing SVM that uses only classification information as their input. In this paper, the universal Kriging method is used to obtain locations of virtual samples to improve the accuracy of the limit state function for highly nonlinear problems. A sequential sampling strategy effectively inserts new samples near the limit state function. In sampling-based RBDO, Monte Carlo simulation (MCS) is used for the reliability analysis and probabilistic sensitivity analysis. Since SVM is an explicit classification method, unlike implicit methods, computational cost for evaluating a large number of MCS samples can be significantly reduced. Several efficiency strategies, such as the hyper-spherical local window for generation. of the limit state function and the Transformations/Gibbs sampling method to generate uniform samples in the hyper-sphere, are also applied. Examples show that the proposed sampling-based RBDO using VSVM yields better efficiency in terms of the number of required samples and the computational cost for evaluating MCS samples while maintaining accuracy similar to that of sampling-based RBDO using the implicit dynamic Kriging (D-Kriging) method. C1 [Song, Hyeongjin; Choi, K. K.] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Zhao, Liang] Schlumberger, Houston, TX 77073 USA. [Lamb, David] US Army, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM hyesong@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu; ilee@engr.uconn.edu; lzhao01@slb.com; david.lamb@us.army.mil RI Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU ARO Project [W911NF-09-1-0250]; National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology [R32-2008-000-10161-0] FX The research is jointly supported by the ARO Project W911NF-09-1-0250 and the Automotive Research Center, which is sponsored by the U.S. Army TARDEC. The research is also supported by the World Class University Program through the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (Grant Number R32-2008-000-10161-0 in 2009). These supports are greatly appreciated. NR 56 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4502-8 PY 2012 BP 1213 EP + PG 4 WC Engineering, Industrial; Engineering, Mechanical SC Engineering GA BA4KY UT WOS:000335932800113 ER PT B AU Cho, H Choi, KK Lee, I Gorsich, D AF Cho, Hyunkyoo Choi, K. K. Lee, Ikjin Gorsich, David GP ASME TI Confidence Level Estimation and Design Sensitivity Analysis for Confidence-based RBDO\\ SO PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES AND COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE 2012, VOL 3, PTS A AND B LA English DT Proceedings Paper CT ASME International Design Engineering Technical Conferences/Computers Information in Engineering Conference CY AUG 12-15, 2012 CL Chicago, IL SP ASME, Design Engn Div, ASME, Comp & Informat Engn Div DE Limited Input Data; Uncertainty of Input Distribution Model; Reliability Analysis Output; Distribution of Output; Confidence Level; Sensitivity Analysis of Confidence Level; Bayesian Approach; Confidence-based RBDO ID RELIABILITY; OPTIMIZATION; UNCERTAINTY; PROBABILITY; INFORMATION AB In practical engineering problems, often only limited input data are available to generate the input distribution model. The insufficient input data induces uncertainty on the input distribution model, and this uncertainty will cause us to lose confidence in the optimum design obtained using the reliability-based design optimization (RBDO) method. Uncertainty on the input distribution model requires us to consider the reliability analysis output, which is defined as the probability of failure, to follow a probabilistic distribution. This paper proposes a new formulation for the confidence-based RBDO method and design sensitivity analysis of the confidence level. The probability of the reliability analysis output is obtained with consecutive conditional probabilities of input distribution parameters and input distribution types using a Bayesian approach. The approximate conditional probabilities of input distribution parameters and types are suggested under certain assumptions. The Monte Carlo simulation is applied to practically calculate the output distribution, and the copula is used to describe the correlated input distribution types. A confidence-based RBDO problem is formulated using the derived the distribution of output. In this new formulation, the probabilistic constraint is modified to include both the target reliability and the target confidence level. Finally, the sensitivity of the confidence level, which is a new probabilistic constraint, is derived to support an efficient optimization process. Using accurate surrogate models, the proposed method does not require generation of additional surrogate models during the RBDO iteration; it only requires several evaluations of the same surrogate models. Hence, the efficiency of the method is obtained. For the numerical example, the confidence level is calculated and the accuracy of the derived sensitivity is verified when only limited data are available. C1 [Cho, Hyunkyoo; Choi, K. K.] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Lee, Ikjin] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA. [Gorsich, David] US Army, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM hyunkyoo-cho@uiowa.edu; kkchoi@engineering.uiowa.edu; ilee@engr.uconn.edu; david.lamb@us.armv.mil RI Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU ARO Project [W911NF-09-1-0250]; National Research Foundation of Korea (NRF); Ministry of Education, Science and Technology [R32-2008-000-10161-0] FX The research is jointly supported by the ARO Project W911NF-09-1-0250 and the Automotive Research Center, which is sponsored by the U.S. Army TARDEC. The research is also supported by the World Class University Program through the National Research Foundation of Korea (NRF) grant funded by the Ministry of Education, Science and Technology (Grant Number R32-2008-000-10161-0 in 2009). These supports are greatly appreciated. NR 26 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4502-8 PY 2012 BP 1227 EP + PG 3 WC Engineering, Industrial; Engineering, Mechanical SC Engineering GA BA4KY UT WOS:000335932800114 ER PT B AU Goyings, R Arnas, O AF Goyings, Ryan Arnas, Oezer GP ASME TI EXERGY VERSUS ENERGY ANALYSIS: ADVANTAGES AND DISADVANTAGES IN TEACHING OF THERMODYNAMICS SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 3 LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst AB In a course of thermodynamics, in general, and gas turbine analysis, in particular as stand alone or within a cogeneration situation, teaching within the concepts of energy or exergy has become controversial particularly since most teachers of thermodynamics at the undergraduate level are not too familiar with the advantages of exergy analysis and thus do not cover the material from that point of view. In this paper, we will go through the pedagogical implications of teaching thermodynamics using both approaches and attempt to show and convince people that exergetic analyses are superior to any other approach in the teaching of thermodynamics. The bottom line and the ultimate goal is the precise teaching of the subject matter. C1 [Goyings, Ryan; Arnas, Oezer] US Mil Acad, West Point, NY 10996 USA. RP Goyings, R (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4469-4 PY 2012 BP 457 EP 461 PG 5 WC Education, Scientific Disciplines; Energy & Fuels; Engineering, Mechanical SC Education & Educational Research; Energy & Fuels; Engineering GA BA4HD UT WOS:000335710200045 ER PT B AU Benson, M Yapa, S Elkins, C Eaton, JK AF Benson, Michael Yapa, Sayuri Elkins, Chris Eaton, John K. GP ASME TI EXPERIMENTAL-BASED REDESIGNS FOR TRAILING EDGE FILM COOLING OF GAS TURBINE BLADES SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 4, PTS A AND B LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst ID PERFORMANCE; AIRFOILS; CUTBACK AB Magnetic resonance imaging experiments have provided the three-dimensional mean concentration and three component mean velocity field for a typical trailing edge film-cooling cutback geometry built into a conventional uncambered airfoil. This geometry is typical of modern aircraft engines and includes three dimensional slot jets separated by tapered lands. Previous analysis of these data identified the critical mean flow structures that contribute to rapid mixing and low effectiveness in the fully turbulent flow. Three new trailing edge geometries were designed to modify the large scale mean flow structures responsible for surface effectiveness degradation. One modification called the Dolphin Nose attempted to weaken strong vortex flows by reducing three dimensionality near the slot breakout. This design changed the flow structure but resulted in, minimal improvement in the surface effectiveness. Two other designs called the Shield and Rounded Shield changed the land planform and added an overhanging land edge while maintaining the same breakout surface. These designs substantially modified the vortex structure and improved the surface effectiveness by as much as 30%. Improvements included superior coolant uniformity on the breakout surface which reduces potential thermal stresses. The utilization of the time averaged data from combined magnetic resonance velocimetry (MRV) and concentration (MRC) experiments for designing improved trailing edge breakout film cooling is demonstrated. C1 [Benson, Michael] US Mil Acad, West Point, NY 10996 USA. [Yapa, Sayuri; Elkins, Chris; Eaton, John K.] Stanford Univ, Stanford, CA 94305 USA. RP Benson, M (reprint author), US Mil Acad, West Point, NY 10996 USA. FU General Electric under the University; U. S. Army Research Office [57392-EG-II] FX Financial support for the project was provided by General Electric under the University Strategic Alliance program. In addition, this material is based upon work supported in part by the U. S. Army Research Office under contract/grant number 57392-EG-II. Use of the facilities at the Richard M. Lucas Center for Magnetic Resonance Spectroscopy and Imaging is gratefully acknowledged. The authors wish to thank the United States Army for funding the first author in his doctoral studies at Stanford, and the reviewers whose suggestions have improved the quality of the paper. The views expressed herein are those of the authors and do not purport to reflect the position of the Department of the Army, or the Department of Defense. NR 26 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4470-0 PY 2012 BP 1175 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA4JP UT WOS:000335868900104 ER PT B AU Ling, J Yapa, SD Benson, MJ Elkins, CJ Eaton, JK AF Ling, Julia Yapa, Sayuri D. Benson, Michael J. Elkins, Christopher J. Eaton, John K. GP ASME TI 3D VELOCITY AND SCALAR FIELD MEASUREMENTS OF AN AIRFOIL TRAILING EDGE WITH SLOT FILM COOLING: THE EFFECT OF AN INTERNAL STRUCTURE IN THE SLOT SO PROCEEDINGS OF THE ASME TURBO EXPO 2012, VOL 4, PTS A AND B LA English DT Proceedings Paper CT ASME Turbo Expo 2012 CY JUN 11-15, 2012 CL Copenhagen, DENMARK SP Int Gas Turbine Inst ID CUTBACK AB Measurements of the 3D velocity and concentration fields were obtained using magnetic resonance imaging for a pressure side cutback film cooling experiment. The cutback geometry consisted of rectangular slots separated by straight lands; inside each of the slots was an airfoil-shaped blockage. The results from this trailing edge configuration, the "island airfoil," are compared to the results obtained with the "generic airfoil," a geometry with narrower slots, wider, tapered lands, and no blockages. The objective was to determine how the narrower lands and internal blockages affected the average film cooling effectiveness and the spanwise uniformity. Velocimetry data revealed that strong horseshoe vortices formed around the blockages in the slots, which resulted in greater coolant non-unfformity on the airfoil breakout surface and in the wake. The thinner lands of the island airfoil allowed the coolant to cover a larger fraction of the trailing edge span, giving a much higher spanwise-averaged surface effectiveness, especially near the slot exit where the generic airfoil lands are widest. C1 [Ling, Julia; Yapa, Sayuri D.; Elkins, Christopher J.; Eaton, John K.] Stanford Univ, Stanford, CA 94305 USA. [Benson, Michael J.] US Mil Acad, West Point, NY USA. RP Ling, J (reprint author), Stanford Univ, Stanford, CA 94305 USA. EM julial@stanford.edu FU National Science Foundation Graduate Fellowship; Stanford Thermal and Fluid Sciences Affiliates Program FX This work was supported by members of the Stanford Thermal and Fluid Sciences Affiliates Program. J. Ling was supported by a National Science Foundation Graduate Fellowship. NR 19 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4470-0 PY 2012 BP 1279 EP + PG 2 WC Engineering, Mechanical SC Engineering GA BA4JP UT WOS:000335868900113 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Introduction Making, Watching, and Using Ritual Introduction SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Editorial Material; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 1 EP + PG 42 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500001 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Interchapter: Ghosts SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 29 EP 31 PG 3 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500002 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI That the Pattern May Subsist: Eliot, English, and the Mind of Europe SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 33 EP 55 PG 23 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500003 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI For European Purposes: Yeats and Fascism Revisited SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 57 EP 86 PG 30 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500004 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Auden (and Company): A Taste for Ritual SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 87 EP 108 PG 22 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500005 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Interchapter: Los Toros no Hablan Ingles SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 109 EP 111 PG 3 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500006 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI We Are One Blood: Lawrence and the Bullfight SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 113 EP 138 PG 26 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500007 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI The European Wound: Bullfighting and the Spanish Civil War SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 139 EP 164 PG 26 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500008 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Interchapter: A Trinity of Converts SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 165 EP 168 PG 4 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500009 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Like Going Home: Greene and Waugh in Mexico SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 169 EP 195 PG 27 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500010 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Keep the Islands Adjacent: David Jones and the "European Thing" SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Article; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 197 EP 226 PG 30 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500011 ER PT B AU Query, PR AF Query, Patrick R. BA Query, PR BF Query, PR TI Writing Ritual Conclusion SO RITUAL AND THE IDEA OF EUROPE IN INTERWAR WRITING LA English DT Editorial Material; Book Chapter C1 US Mil Acad, West Point, NY 10996 USA. RP Query, PR (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-4609-5; 978-1-4094-4608-8 PY 2012 BP 227 EP 231 PG 5 WC Literary Theory & Criticism; Literature SC Literature GA BB5BP UT WOS:000343656500012 ER PT B AU Brauer, EJ AF Brauer, E. J. BE Munoz, RM TI The effect of river training structures on flood heights on the Middle Mississippi River SO RIVER FLOW 2012, VOLS 1 AND 2 LA English DT Proceedings Paper CT 6th International Conference on Fluvial Hydraulics (River Flow) CY SEP 05-07, 2012 CL San Jose, COSTA RICA SP Colegio Ingenieros Civiles Costa Rica, Int Assoc Hydro Environm Engn & Res, Comm Fluvial Hydraul ID HISTORY AB The U.S. Army Corps of Engineers (Corps) uses river training structures in the Middle Mississippi River to accomplish their mission of providing a safe and dependable navigation channel. The Corps continues to monitor the physical effects of these structures on bathymetry, velocity and water surfaces. This paper discusses the research conducted to further the understanding of the effect of river training structures on water surfaces. This comprehensive study conducted by both the Corps and external experts from other federal agencies and academia in the fields of river data collection, river engineering, geomorphology, hydraulics and statistics, included an analysis of past research, all available gage data, historic measurement techniques and instrumentation and their effect on the rating curve and specific gage analysis. These studies all lead to the conclusion that river training structures do not have an effect on water surfaces at higher flows. C1 US Army, Corps Engn, St Louis, MO 63132 USA. RP Brauer, EJ (reprint author), US Army, Corps Engn, St Louis, MO 63132 USA. NR 25 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-203-07635-4; 978-0-415-62129-8 PY 2012 BP 1245 EP 1252 PG 8 WC Engineering, Environmental; Engineering, Civil; Water Resources SC Engineering; Water Resources GA BB8ZI UT WOS:000347871500166 ER PT B AU France, J AF France, John BE Gertwagen, R Jeffreys, E TI Mercenaries and Capuchins in Southern France in the Late Twelfth Century SO SHIPPING, TRADE AND CRUSADE IN THE MEDIEVAL MEDITERRANEAN: STUDIES IN HONOUR OF JOHN PRYOR LA English DT Article; Book Chapter C1 [France, John] Swansea Univ, Swansea, W Glam, Wales. [France, John] US Mil Acad, Mil Hist, West Point, NY USA. RP France, J (reprint author), Swansea Univ, Swansea, W Glam, Wales. NR 83 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-1-4094-3754-3; 978-1-4094-3753-6 PY 2012 BP 289 EP 315 PG 27 WC Medieval & Renaissance Studies SC Arts & Humanities - Other Topics GA BC0OF UT WOS:000349253700016 ER PT J AU Jabbour, RE Wade, MM Deshpande, SV Stanford, MF Zulich, AW Snyder, AP AF Jabbour, Rabih E. Wade, Mary M. Deshpande, Samir V. Stanford, Michael F. Zulich, Alan W. Snyder, A. Peter BE Prasain, JK TI Comparative Proteomics of Tandem Mass Spectrometry Analyses for Bacterial Strains Identification and Differentiation SO TANDEM MASS SPECTROSCOPY - APPLICATIONS AND PRINCIPLES LA English DT Article; Book Chapter ID ENTEROPATHOGENIC ESCHERICHIA-COLI; RAPID IDENTIFICATION; YERSINIA-PESTIS; SHOTGUN PROTEOMICS; PROTEIN EXPRESSION; MEMBRANE-PROTEINS; GENETIC-LOCUS; DATABASE; CLASSIFICATION; MICROORGANISMS C1 [Jabbour, Rabih E.; Wade, Mary M.; Stanford, Michael F.; Zulich, Alan W.; Snyder, A. Peter] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. [Deshpande, Samir V.] Sci & Technol Corp, Edgewood, MD USA. RP Jabbour, RE (reprint author), US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA. NR 66 TC 0 Z9 0 U1 0 U2 0 PU INTECH EUROPE PI RIJEKA PA JANEZA TRDINE9, RIJEKA, 51000, CROATIA BN 978-953-51-0141-3 PY 2012 BP 199 EP 220 D2 10.5772/1327 PG 22 WC Biochemical Research Methods; Spectroscopy SC Biochemistry & Molecular Biology; Spectroscopy GA BG2EJ UT WOS:000387291400010 ER PT J AU Hawkins, T Drozdz, S AF Hawkins, Todd Drozdz, Susan BE Rawlins, JW Storey, RF TI CATHODIC NANOCOATING TECHNOLOGY FOR CORROSION CONTROL OF STEEL STRUCTURES SO WATERBORNE SYMPOSIUM: PROCEEDINGS OF THE THIRTY-NINTH ANNUAL INTERNATIONAL WATERBORNE, HIGH-SOLIDS, AND POWDER COATINGS SYMPOSIUM LA English DT Proceedings Paper CT 39th Annual International Waterborne, High-Solids, and Powder Coatings Symposium CY FEB 13-17, 2012 CL New Orleans, LA SP Univ Southern Mississippi, Sch Polymers & High Performance Mat AB Traditional organic coatings which provide cathodic protection such as zinc-rich coatings exhibit several major drawbacks. To achieve electrical conductivity zinc-rich coatings rely on tangential contact between zinc dust particles. This results in over pigmentation of the binder exceeding the critical pigment volume concentration of the resin system. This results in an inferior coating with poor physical and mechanical properties. In addition, Zinc-rich coatings limit the amount of corrosion protection they can provide. The utilization of carbon nanotechnology overcomes the issues noted above. Lower zinc loading levels produce a strong and stable coating film optimized well under the critical pigment volume concentration of the resin. The strong and conductive network of carbon nanotube ropes strengthens and stiffens the film while building an electron path through the binder system. Essentially less zinc provides more availability for cathodic protection to damaged coating areas via the carbon nanotube ropes. Extending service life has a positive environmental and economic impact on waste reduction, energy and raw material consumption. Lowering zinc levels correspondingly lowers the levels of toxic heavy metals such as cadmium and lead that are always present with zinc. High-solids and low VOC coating systems are easy to formulate. C1 [Hawkins, Todd] Tesla NanoCoatings Ltd, Massillon, OH 44647 USA. [Drozdz, Susan] US Army, Engn Res & Dev Ctr, Champaign, IL USA. RP Hawkins, T (reprint author), Tesla NanoCoatings Ltd, Massillon, OH 44647 USA. EM todd@teslanano.com; Susan.A.Drozdz@erdc.usace.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU DESTECH PUBLICATIONS, INC PI LANCASTER PA 439 DUKE STREET, LANCASTER, PA 17602-4967 USA BN 978-1-60595-074-7 PY 2012 BP 100 EP 105 PG 6 WC Materials Science, Coatings & Films; Polymer Science SC Materials Science; Polymer Science GA BC2RH UT WOS:000351274000007 ER PT S AU Murray, W AF Murray, Williamson BE OConnell, ME TI History and War: The Grim Record of the Past SO WHAT IS WAR?: AN INVESTIGATION IN THE WAKE OF 9/11 SE International Humanitarian Law Series LA English DT Article; Book Chapter C1 [Murray, Williamson] US Air Force, Washington, DC USA. [Murray, Williamson] Ohio State Univ, Columbus, OH 43210 USA. [Murray, Williamson] Air War Coll, Montgomery, AL USA. [Murray, Williamson] US Mil Acad, West Point, NY USA. [Murray, Williamson] Naval War Coll, Newport, RI USA. [Murray, Williamson] Marine Corps Univ, Quantico, VA USA. [Murray, Williamson] Smithsonians Air & Space Museum, Washington, DC USA. [Murray, Williamson] Army War Coll, Carlisle, PA USA. RP Murray, W (reprint author), US Naval Acad, Annapolis, MD 21402 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARTINUS NIJHOFF PI DORDRECHT PA PO BOX 163, AD-3300 DORDRECHT, NETHERLANDS SN 1389-6776 BN 978-90-47-42581-6; 978-90-04-17234-0 J9 INT HUMANIT LAW PY 2012 VL 37 BP 183 EP 193 D2 10.1163/9789047425816 PG 11 WC International Relations; Law SC International Relations; Government & Law GA BA6KZ UT WOS:000337173100014 ER PT J AU Mal, S Yang, TH Gupta, P Prater, JT Narayan, J AF Mal, Siddhartha Yang, Tsung-Han Gupta, P. Prater, J. T. Narayan, J. TI Thin film epitaxy and magnetic properties of STO/TiN buffered ZnO on Si(0 0 1) substrates (vol 59, pg 2526, 2011) SO ACTA MATERIALIA LA English DT Correction C1 [Mal, Siddhartha; Yang, Tsung-Han; Gupta, P.; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM smal@ncsu.edu NR 1 TC 1 Z9 1 U1 1 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD JAN PY 2012 VL 60 IS 1 BP 457 EP 457 DI 10.1016/j.actamat.2011.08.010 PG 1 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 858SF UT WOS:000297822300044 ER PT J AU Finkelstein, A Kunis, G Berkutzki, T Ronen, A Krivoy, A Yoles, E Last, D Mardor, Y Van Shura, K McFarland, E Capacio, BA Eisner, C Gonzales, M Gregorowicz, D Eisenkraft, A McDonough, JH Schwartz, M AF Finkelstein, Arseny Kunis, Gilad Berkutzki, Tamara Ronen, Ayal Krivoy, Amir Yoles, Eti Last, David Mardor, Yael Van Shura, Kerry McFarland, Emylee Capacio, Benedict A. Eisner, Claire Gonzales, Mary Gregorowicz, Danise Eisenkraft, Arik McDonough, John H. Schwartz, Michal TI Immunomodulation by poly-YE reduces organophosphate-induced brain damage SO BRAIN BEHAVIOR AND IMMUNITY LA English DT Article DE Organophosphate; Soman; Paraoxon; Immunomodulation; Neuroprotection; Immune; Pesticide; T cells; Tregs ID CENTRAL-NERVOUS-SYSTEM; REGULATORY T-CELLS; AMYOTROPHIC-LATERAL-SCLEROSIS; SOMAN-INDUCED SEIZURES; ALZHEIMERS-DISEASE; NEURODEGENERATIVE DISEASES; COGNITIVE DYSFUNCTION; SARIN ATTACK; LONG-TERM; MICROGLIA AB Accidental organophosphate poisoning resulting from environmental or occupational exposure, as well as the deliberate use of nerve agents on the battlefield or by terrorists, remain major threats for multicasualty events, with no effective therapies yet available. Even transient exposure to organophosphorous compounds may lead to brain damage associated with microglial activation and to long-lasting neurological and psychological deficits. Regulation of the microglial response by adaptive immunity was previously shown to reduce the consequences of acute insult to the central nervous system (CNS). Here, we tested whether an immunization-based treatment that affects the properties of T regulatory cells (Tregs) can reduce brain damage following organophosphate intoxication, as a supplement to the standard antidotal protocol. Rats were intoxicated by acute exposure to the nerve agent soman, or the organophosphate pesticide, paraoxon, and after 24 h were treated with the immunomodulator, poly-YE. A single injection of poly-YE resulted in a significant increase in neuronal survival and tissue preservation. The beneficial effect of poly-YE treatment was associated with specific recruitment of CD4(+) T cells into the brain, reduced microglial activation, and an increase in the levels of brain derived neurotrophic factor (BDNF) in the piriform cortex. These results suggest therapeutic intervention with poly-YE as an immunomodulatory supplementary approach against consequences of organophosphate-induced brain damage. (C) 2011 Elsevier Inc. All rights reserved. C1 [Finkelstein, Arseny; Kunis, Gilad; Ronen, Ayal; Schwartz, Michal] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel. [Berkutzki, Tamara] Weizmann Inst Sci, Dept Vet Resources, IL-76100 Rehovot, Israel. [Yoles, Eti] Proneuron Biotechnol, Ness Ziona, Israel. [Last, David; Mardor, Yael] Tel Aviv Univ, Adv Technol Ctr, Sheba Med Center, Sackler Fac Med, IL-69978 Tel Aviv, Israel. [Van Shura, Kerry; McFarland, Emylee; Capacio, Benedict A.; Eisner, Claire; Gonzales, Mary; Gregorowicz, Danise; McDonough, John H.] USA, Div Res, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. RP Schwartz, M (reprint author), Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel. EM michal.schwartz@weizmann.ac.il OI Finkelstein, Arseny/0000-0003-1480-5670 FU Israel Defense Force - Medical Corps; Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S T Division FX The authors thank Mrs. Margalit Azulay for her devoted assistance with animal care, and Mr. Igor Makarovsky for preparation of the chemical reagents. M.S. holds the Maurice and use Katz Professorial Chair in Neuroimmunology. The opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. This research was supported by the Israel Defense Force - Medical Corps and the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S & T Division. NR 68 TC 4 Z9 4 U1 0 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0889-1591 J9 BRAIN BEHAV IMMUN JI Brain Behav. Immun. PD JAN PY 2012 VL 26 IS 1 BP 159 EP 169 DI 10.1016/j.bbi.2011.09.002 PG 11 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 855AC UT WOS:000297534900020 PM 21925261 ER PT J AU Zhao, SB Wang, RY Nguyen, H Becker, JJ Gagne, MR AF Zhao, Shu-Bin Wang, Rui-Yao Ha Nguyen Becker, Jennifer J. Gagne, Michel R. TI Electrophilic fluorination of cationic Pt-aryl complexes SO CHEMICAL COMMUNICATIONS LA English DT Article ID METAL-MEDIATED FORMATION; CARBON-HALOGEN BONDS; REDUCTIVE ELIMINATION; PT(IV) COMPLEXES; PALLADIUM; CHEMISTRY; FLUORIDES; IODIDE; REACTIVITY; MECHANISM AB The electrophilic fluorination of several (triphos)Pt-aryl(+) establishes the first example of aryl-F coupling from a Pt center. C1 [Zhao, Shu-Bin; Ha Nguyen; Gagne, Michel R.] Univ N Carolina, Dept Chem, Caudill Labs, Chapel Hill, NC 27599 USA. [Wang, Rui-Yao] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada. [Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, Caudill Labs, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu FU NIH [GM-60578]; Army Research Office; NSERC of Canada FX We acknowledge the generous support of the NIH (GM-60578) and Army Research Office Staff Research Program. SZ thanks NSERC of Canada for a Postdoctoral Fellowship. NR 39 TC 19 Z9 19 U1 1 U2 22 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1359-7345 J9 CHEM COMMUN JI Chem. Commun. PY 2012 VL 48 IS 3 BP 443 EP 445 DI 10.1039/c1cc15006e PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 857GB UT WOS:000297704500034 PM 22080210 ER PT J AU Brunye, TT Gardony, A Mahoney, CR Taylor, HA AF Brunye, Tad T. Gardony, Aaron Mahoney, Caroline R. Taylor, Holly A. TI Going to town: Visualized perspectives and navigation through virtual environments SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE Spatial cognition; Spatial perspectives; Navigation; Spatial visualizations ID SPATIAL KNOWLEDGE ACQUISITION; INDIVIDUAL-DIFFERENCES; MENTAL REPRESENTATIONS; ROUTE DESCRIPTIONS; SCENE RECOGNITION; COGNITIVE MAP; REAL; EXPERIENCE; HUMANS; MEMORY AB Two experiments examined how spatial learning perspectives support navigation through virtual urban environments. Participants briefly learned the overall layout of a virtual desktop environment, and then were taken on a simulated journey ending at a starting location within the environment. In Experiment 1, during the journey participants watched simulated video feeds either from the front of the vehicle (route perspective), above the vehicle (survey perspective), both feeds simultaneously, or no video at all. Participants then navigated between ten successive landmarks, and we measured indices of spatial and temporal efficiency, and heading error. Results indicated that the route perspective supported a restricted range of local navigation whereas the survey perspective better supported far-space navigation. Experiment 2 demonstrated that the survey perspective also better supports navigation around unexpected detours. Results are discussed with regard to theories of spatial memory and the design of computer-supported spatial visualization technologies. Published by Elsevier Ltd. C1 [Brunye, Tad T.; Gardony, Aaron; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. [Brunye, Tad T.; Gardony, Aaron; Mahoney, Caroline R.] USA, NSRDEC, Natick, MA 01760 USA. [Taylor, Holly A.] Hansewissensch Kolleg, Delmenhorst, Germany. RP Brunye, TT (reprint author), Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA. EM tadbrunye@hotmail.com NR 62 TC 10 Z9 10 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD JAN PY 2012 VL 28 IS 1 BP 257 EP 266 DI 10.1016/j.chb.2011.09.008 PG 10 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 852YF UT WOS:000297392700030 ER PT J AU Gilman, S AF Gilman, Sol TI Coulometric study of ethanol adsorption at a polycrystalline platinum electrode SO JOURNAL OF POWER SOURCES LA English DT Article DE DMFC; Ethanol; Ethanol fuel cells; Adsorption ID TIME FTIR SPECTROSCOPY; FUEL-CELL; OXIDATION; ELECTROOXIDATION; ACID; ACETALDEHYDE; MECHANISM; SURFACES; ELECTROCATALYSIS; CATALYSTS AB For the first time, use of a novel pre-conditioning sequence and measurements of hydrogen blockage during fast cathodic scans has enabled the determination of rates of accumulation of ethanolic species on the surface of a platinum electrode under well-controlled conditions of surface cleanliness/activity and mass transport. For dilute solutions of ethanol in 1 N perchloric acid (HClO(4)), oxidative adsorption rates maximize at 0.3 V. drop off at more cathodic potentials due to competition with adsorbed hydrogen and drop off at more anodic potentials due to oxidative processes that produce products released to the electrolyte. The time and concentration dependence of adsorption follows relationships that are common for adsorption on a heterogeneous surface. Some evidence are presented supporting a mechanism for production of soluble products that does not involve the adsorbed species that are detected through the measurement of blockage of hydrogen adsorption sites. Published by Elsevier B.V. C1 USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. RP Gilman, S (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM sol.gilman.civ@mail.mil NR 31 TC 3 Z9 3 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JAN 1 PY 2012 VL 197 BP 65 EP 71 DI 10.1016/j.jpowsour.2011.09.041 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 852YZ UT WOS:000297394700009 ER PT J AU Wu, HC Lee, E Wu, NL Jow, TR AF Wu, Hsien-Chang Lee, Eric Wu, Nae-Lih Jow, T. Richard TI Effects of current collectors on power performance of Li4Ti5O12 anode for Li-ion battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium-ion battery; Lithium titanate anode; Current collector; Aluminum; Copper; Carbon coating ID AL CURRENT-COLLECTOR; LITHIUM; SUPERCAPACITORS AB The effects of current collector on the charge/discharge capacity and cycle stability of Li4Ti5O12 (LTO) electrode under high C-rates (up to 20C) have been investigated by applying five types of current collectors, including a Al foil, an anodization-etched Al (E-Al), the same etched Al with a conformal C coating (C-E-Al), a Cu foil (Cu) and the same Cu foil with a C coating (C-Cu). The C coatings on both metal current collectors are deposited by a chemical vapor deposition process using CH4 at 600 degrees C. The capacities of the LTO electrodes above 1 C rate are in the order of Al < E-Al < Cu similar to C-E-Al < C-Cu, exhibiting remarkable enhancement in rate performance by the C-coating for both metals. Surface analyses indicate that the enhancement can be attributed to the combination of two factors, including removal of the native oxide layer and modification of surface hydrophobicity, which improves adhesion of active layer, on the current collector surface. Both contribute to the reduction of the resistance at the current-collector/active layer interface. All electrodes show good cycle stability. (C) 2011 Elsevier B.V. All rights reserved. C1 [Wu, Hsien-Chang; Lee, Eric; Wu, Nae-Lih] Natl Taiwan Univ, Dept Chem Engn, Taipei 106, Taiwan. [Jow, T. Richard] USA, Res Lab, Adelphi, MD 20783 USA. RP Wu, NL (reprint author), Natl Taiwan Univ, Dept Chem Engn, Taipei 106, Taiwan. EM nlw001@ntu.edu.tw FU National Science Council of Taiwan, ROC [NSC-3114-E-002-012]; U.S. Army Research Laboratory, USA [FA 2386-10-1-4155 AOARD 104155] FX This work is partially supported by National Science Council of Taiwan, ROC (NSC-3114-E-002-012) and by U.S. Army Research Laboratory, USA under grant # FA 2386-10-1-4155 AOARD 104155. NR 11 TC 20 Z9 20 U1 11 U2 92 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JAN 1 PY 2012 VL 197 BP 301 EP 304 DI 10.1016/j.jpowsour.2011.09.014 PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 852YZ UT WOS:000297394700042 ER PT J AU Akin, TG Kennedy, S Dribus, B Marzuola, JL Johnson, L Alexander, J Abraham, ERI AF Akin, T. G. Kennedy, Sharon Dribus, Ben Marzuola, Jeremy L. Johnson, Lise Alexander, Jason Abraham, E. R. I. TI Bose-Einstein condensation transition studies for atoms confined in Laguerre-Gaussian laser modes SO OPTICS COMMUNICATIONS LA English DT Article DE Laguerre-Gaussian beams; Bose-Einstein condensation; Atom traps; Laser cooling and trapping; Vorticies ID GROUND-STATE; MAGNETIC TRAP; VORTICES; GAS AB Multiply-connected traps for cold, neutral atoms fix vortex cores of quantum gases. Laguerre-Gaussian laser modes are ideal for such traps due to their phase stability. We report theoretical calculations of the Bose-Einstein condensation transition properties and thermal characteristics of neutral atoms trapped in multiply connected geometries formed by Laguerre-Gaussian (LG(p)(l)) beams. Specifically, we consider atoms confined to the anti-node of a LG(0)(1) laser mode detuned to the red of an atomic resonance frequency, and those confined in the node of a blue-detuned LG(1)(1) beam. We compare the results of using the full potential to those approximating the potential minimum with a simple harmonic oscillator potential. We find that deviations between calculations of the full potential and the simple harmonic oscillator can be up to 3%-8% for trap parameters consistent with typical experiments. (C) 2011 Elsevier B.V. All rights reserved. C1 [Akin, T. G.; Kennedy, Sharon; Abraham, E. R. I.] Univ Oklahoma, Homer L Dodge Dept Phys & Astron, Norman, OK 73019 USA. [Dribus, Ben] Louisiana State Univ, Baton Rouge, LA 70803 USA. [Marzuola, Jeremy L.] Univ N Carolina, Dept Math, Chapel Hill, NC 27599 USA. [Johnson, Lise] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA. [Alexander, Jason] USA, Cold Atom Opt Grp, Res Lab, Adelphi, MD USA. RP Abraham, ERI (reprint author), Univ Oklahoma, Homer L Dodge Dept Phys & Astron, 440 W Brooks St, Norman, OK 73019 USA. EM abraham@nhn.ou.edu FU Research Corporation; Digital Optics Corporation; University of Oklahoma FX This work is supported by the Research Corporation, Digital Optics Corporation, and The University of Oklahoma. NR 27 TC 1 Z9 1 U1 2 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JAN 1 PY 2012 VL 285 IS 1 BP 84 EP 89 DI 10.1016/j.optcom.2011.09.011 PG 6 WC Optics SC Optics GA 850YC UT WOS:000297234500016 ER PT J AU Shabana, AA Hamed, AM Mohamed, ANA Jayakumar, P Letherwood, MD AF Shabana, Ahmed A. Hamed, Ashraf M. Mohamed, Abdel-Nasser A. Jayakumar, Paramsothy Letherwood, Michael D. TI Use of B-Spline in the Finite Element Analysis: Comparison With ANCF Geometry SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS LA English DT Article DE geometric discontinuities; finite element; multibody systems; B-spline; NURBS ID NODAL COORDINATE FORMULATION; FLEXIBLE MULTIBODY SYSTEMS; DEFORMABLE BEAM; PLATE AB This paper examines the limitations of using B-spline representation as an analysis tool by comparing its geometry with the nonlinear finite element absolute nodal coordinate formulation (ANCF) geometry. It is shown that while both B-spline and ANCF geometries can be used to model nonstructural discontinuities using linear connectivity conditions, there are fundamental differences between B-spline and ANCF geometries. First, while B-spline geometry can always be converted to ANCF geometry, the converse is not true; that is, ANCF geometry cannot always be converted to B-spline geometry. Second, because of the rigid structure of the B-spline recurrence formula, there are restrictions on the order of the parameters and basis functions used in the polynomial interpolation; this in turn can lead to models that have significantly larger number of degrees of freedom as compared to those obtained using ANCF geometry. Third, in addition to the known fact that B-spline does not allow for straightforward modeling of T-junctions, B-spline representation cannot be used in a straightforward manner to model structural discontinuities. It is shown in this investigation that ANCF geometric description can be used to develop new spatial chain models governed by linear connectivity conditions which can be applied at a preprocessing stage allowing for an efficient elimination of the dependent variables. The modes of the deformations at the definition points of the joints that allow for rigid body rotations between ANCF finite elements are discussed. The use of the linear connectivity conditions with ANCF spatial finite elements leads to a constant inertia matrix and zero Coriolis and centrifugal forces. The fully parameterized structural ANCF finite elements used in this study allow for the deformation of the cross section and capture the coupling between this deformation and the stretch and bending. A new chain model that employs different degrees of continuity for different coordinates at the joint definition points is developed in this investigation. In the case of cubic polynomial approximation, C-1 continuity conditions are used for the coordinate line along the joint axis; while C-0 continuity conditions are used for the other coordinate lines. This allows for having arbitrary large rigid body rotation about the axis of the joint that connects two flexible links. Numerical examples are presented in order to demonstrate the use of the formulations developed in this paper. [DOI: 10.1115/1.4004377] C1 [Shabana, Ahmed A.; Hamed, Ashraf M.; Mohamed, Abdel-Nasser A.] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA. [Jayakumar, Paramsothy; Letherwood, Michael D.] US Army RDECOM TARDEC, Warren, MI 48397 USA. RP Shabana, AA (reprint author), Univ Illinois, Dept Mech & Ind Engn, 842 W Taylor St, Chicago, IL 60607 USA. EM shabana@uic.edu; aabdal5@uic.edu; amoham25@uic.edu; paramsothy.jayakumar@us.army.mil; mike.letherwood@us.army.mil FU U.S. Army Tank-Automotive Research, Development and Engineering Center (TARDEC) [W911NF-07-D-0001]; National Science Foundation Office of International Programs [0808399] FX This research was supported by the U.S. Army Tank-Automotive Research, Development and Engineering Center (TARDEC) (Contract No. W911NF-07-D-0001) and, in part, by the National Science Foundation Office of International Programs (Project No. 0808399). NR 24 TC 9 Z9 9 U1 0 U2 14 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1555-1423 J9 J COMPUT NONLIN DYN JI J. Comput. Nonlinear Dyn. PD JAN PY 2012 VL 7 IS 1 AR 011008 DI 10.1115/1.4004377 PG 8 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 848DI UT WOS:000297028800008 ER PT J AU Hromadka, TV Zillmer, D AF Hromadka, T. V., II Zillmer, D. TI Boundary element modeling with variable nodal and collocation point locations SO ADVANCES IN ENGINEERING SOFTWARE LA English DT Article DE Boundary elements; Complex Variable Boundary Element Method (CVBEM); Nodal point locations; Collocation point locations; Hilbert space; Complex variables AB In both the real variable and Complex Variable Boundary Element Methods (CVBEM), nodal points are typically located on the problem boundary and then various techniques are used to fit boundary condition values at the nodal point locations such as collocation (equating approximation function to boundary condition values at a discrete set of locations on the boundary) or least squares minimization on the boundary, among others. In this paper, the CVBEM is used to examine the significant improvement in approximation accuracy achieved by using as additional approximation variables the actual nodal point locations (both on the problem boundary as well as exterior of the problem domain union boundary), and to also use as additional approximation variables the locations where boundary conditions are fitted (i.e. collocation points). The developed concepts also apply directly to the more commonly used real variable boundary element technique. Our results show that significant improvement in modeling accuracy is achieved by including the nodal point coordinates and also the collocation point coordinates as additional variables to be optimized. Published by Elsevier Ltd. C1 [Hromadka, T. V., II] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Hromadka, TV (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM Ted@PHDPHDPHD.com; Devon.Zillmer@G-MAIL.com NR 4 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0965-9978 J9 ADV ENG SOFTW JI Adv. Eng. Softw. PD JAN PY 2012 VL 43 IS 1 BP 96 EP 103 DI 10.1016/j.advengsoft.2011.07.003 PG 8 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Engineering, Multidisciplinary SC Computer Science; Engineering GA 847VF UT WOS:000296999900010 ER PT J AU Morris, CJ Wilkins, P May, C Zakar, E Weihs, TP AF Morris, Christopher J. Wilkins, Paul May, Chadd Zakar, Eugene Weihs, Timothy P. TI Streak spectrograph temperature analysis from electrically exploded Ni/Al nanolaminates SO THIN SOLID FILMS LA English DT Article DE Exothermic mixing; Reactive laminates; Streak camera spectroscopy; Plasma temperatures ID EMISSION; FOILS; PLASMA; COMPOSITES AB We report on electrically-induced heating and mixing of multilayered nickel/aluminum (Ni/Al) laminates observed by streak camera emission spectroscopy. Past experiments probing the kinetic energy of material ejected from the reaction zone indicate that additional kinetic energy originates from Ni/Al samples, presumably from exothermic mixing between the two metals. Here we examine streak spectrographs of similar experiments to determine the presence of expected elements and their temperatures. We conducted these experiments in rough vacuum, but found the emission to be dominated by argon (Ar) and nitrogen (N) lines in addition to the expected emission of Al and Ni, which were also present. Using the spectral information of Ar, we analyzed the relative intensities of four Ar peaks between 425 and 455 nm, with respect to their expected Boltzmann distributions to yield temperatures as a function of time. These temperatures were 2.24-2.59 eV for Al samples, and 2.93-3.27 eV for both Ni and Ni/Al samples, and were within estimates based on the measured electrical energy delivered to each device. The higher Ni/Al sample temperatures seemed to validate our past measurements of increased kinetic energy and the apparent rapid exothermic mixing between Ni and Al, although Ni samples yielded surprisingly high temperatures as well. These results may be important for future nanomanufacturing techniques involving localized heating from reactive Ni/Al multilayers, where the precise control of spatial temperatures may necessitate an equally precise temporal control of the reaction. Published by Elsevier B.V. C1 [Morris, Christopher J.] USA, Res Lab, RDRL SER L, Adelphi, MD 20783 USA. [Wilkins, Paul; May, Chadd] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Weihs, Timothy P.] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. RP Morris, CJ (reprint author), USA, Res Lab, RDRL SER L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christopher.j.morris58.civ@mail.mil RI Weihs, Timothy/A-3313-2010 FU Office Naval Research [N00014-07-1-0740] FX The authors gratefully acknowledge Dr. Kevin McNesby at U.S. Army Research Laboratory for helpful discussions on analysis of streak emission spectroscopy. Professor T. P. Weihs acknowledges the financial support of the Office Naval Research through Grant No. N00014-07-1-0740. NR 24 TC 9 Z9 9 U1 0 U2 10 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD DEC 30 PY 2011 VL 520 IS 5 BP 1645 EP 1650 DI 10.1016/j.tsf.2011.07.043 PG 6 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 878DL UT WOS:000299233000052 ER PT J AU Parker, TC Baechle, D Demaree, JD AF Parker, Thomas C. Baechle, Daniel Demaree, John Derek TI Polymeric barrier coatings via initiated chemical vapor deposition SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Barrier coating; Polymer; iCVD ID MICROSPHERES AB Initiated chemical vapor deposition (iCVD) enables micron sized particles to be coated with conformal polymeric films. Unlike wet chemistries, particle agglomeration is mitigated due to the vapor phase deposition. A custom built iCVD with a rotary evaporator was used to coat a variety of particles with poly(glycidyl methacrylate) (PGMA). Glass beads with average diameters of 355 mu m were coated with a similar to 1 mu m PGMA film. Thermo gravimetric analysis (TGA) was used to assess if the beads were coated with PGMA and to estimate the PGMA thickness. The TGA testing showed a 0.7% mass loss at similar to 275 degrees C, which corresponds to the decomposition temperature of PGMA and a PGMA thickness of -1 mu m. In addition sodium chloride (similar to 355 mu m) particles were coated in the iCVD system again with PGMA. The dissolution rate of these particles in an aqueous solution was found to be reduced by an order of magnitude (versus uncoated NaCl). Finally, NaCl particles with metallic coatings were coated with PGMA and showed a dissolution rate two orders of magnitude slower than the bare NaCl. (C) 2011 Elsevier B.V. All rights reserved. C1 [Parker, Thomas C.; Baechle, Daniel; Demaree, John Derek] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Parker, TC (reprint author), USA, Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM Thomas.C.Parker1@us.army.mil FU Internship/Research Participation Program; U.S. Department of Energy; USARL FX The authors would like to thank Dr. Eric Wetzel (ARL) for helpful insights and discussions in designing and executing these experiments. This project was supported in part by an appointment to the Internship/Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the USARL. NR 12 TC 2 Z9 2 U1 1 U2 5 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 25 PY 2011 VL 206 IS 7 BP 1680 EP 1683 DI 10.1016/j.surfcoat.2011.09.021 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 871BB UT WOS:000298711500027 ER PT J AU Li, HN Wang, N Gong, P Perkins, EJ Zhang, CY AF Li, Haoni Wang, Nan Gong, Ping Perkins, Edward J. Zhang, Chaoyang TI Learning the structure of gene regulatory networks from time series gene expression data SO BMC GENOMICS LA English DT Article AB Background: Dynamic Bayesian Network (DBN) is an approach widely used for reconstruction of gene regulatory networks from time-series microarray data. Its performance in network reconstruction depends on a structure learning algorithm. REVEAL (REVerse Engineering ALgorithm) is one of the algorithms implemented for learning DBN structure and used to reconstruct gene regulatory networks (GRN). However, the two-stage temporal Bayes network (2TBN) structure of DBN that specifies correlation between time slices cannot be obtained by score metrics used in REVEAL. Methods: In this paper, we study a more sophisticated score function for DBN first proposed by Nir Friedman for stationary DBNs structure learning of both initial and transition networks but has not yet been used for reconstruction of GRNs. We implemented Friedman's Bayesian Information Criterion (BIC) score function, modified K2 algorithm to learn Dynamic Bayesian Network structure with the score function and tested the performance of the algorithm for GRN reconstruction with synthetic time series gene expression data generated by GeneNetWeaver and real yeast benchmark experiment data. Results: We implemented an algorithm for DBN structure learning with Friedman's score function, tested it on reconstruction of both synthetic networks and real yeast networks and compared it with REVEAL in the absence or presence of preprocessed network generated by Zou&Conzen's algorithm. By introducing a stationary correlation between two consecutive time slices, Friedman's score function showed a higher precision and recall than the naive REVEAL algorithm. Conclusions: Friedman's score metrics for DBN can be used to reconstruct transition networks and has a great potential to improve the accuracy of gene regulatory network structure prediction with time series gene expression datasets. C1 [Li, Haoni; Wang, Nan; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Gong, Ping] SpecPro Inc, Environm Serv, San Antonio, TX 78216 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Zhang, CY (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. EM chaoyang.zhang@usm.edu FU US Army [W912HZ-08-2-0011]; NSF EPSCoR [EPS-0903787] FX This work was supported by the US Army Corps of Engineers Environmental Quality Program under contract # W912HZ-08-2-0011 and the NSF EPSCoR project "Modeling and Simulation of Complex Systems" (NSF #EPS-0903787). Permission was granted by the Chief of Engineers to publish this information. NR 19 TC 3 Z9 3 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD DEC 23 PY 2011 VL 12 SU 5 AR S13 DI 10.1186/1471-2164-12-S5-S13 PG 8 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 940WB UT WOS:000303922700014 PM 22369588 ER PT J AU Wu, X Li, P Wang, N Gong, P Perkins, EJ Deng, YP Zhang, CY AF Wu, Xi Li, Peng Wang, Nan Gong, Ping Perkins, Edward J. Deng, Youping Zhang, Chaoyang TI State Space Model with hidden variables for reconstruction of gene regulatory networks SO BMC SYSTEMS BIOLOGY LA English DT Article AB Background: State Space Model (SSM) is a relatively new approach to inferring gene regulatory networks. It requires less computational time than Dynamic Bayesian Networks (DBN). There are two types of variables in the linear SSM, observed variables and hidden variables. SSM uses an iterative method, namely Expectation-Maximization, to infer regulatory relationships from microarray datasets. The hidden variables cannot be directly observed from experiments. How to determine the number of hidden variables has a significant impact on the accuracy of network inference. In this study, we used SSM to infer Gene regulatory networks (GRNs) from synthetic time series datasets, investigated Bayesian Information Criterion (BIC) and Principle Component Analysis (PCA) approaches to determining the number of hidden variables in SSM, and evaluated the performance of SSM in comparison with DBN. Method: True GRNs and synthetic gene expression datasets were generated using GeneNetWeaver. Both DBN and linear SSM were used to infer GRNs from the synthetic datasets. The inferred networks were compared with the true networks. Results: Our results show that inference precision varied with the number of hidden variables. For some regulatory networks, the inference precision of DBN was higher but SSM performed better in other cases. Although the overall performance of the two approaches is compatible, SSM is much faster and capable of inferring much larger networks than DBN. Conclusion: This study provides useful information in handling the hidden variables and improving the inference precision. C1 [Wu, Xi; Wang, Nan; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. [Li, Peng] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA. [Gong, Ping] SpecPro Inc, Environm Serv, San Antonio, TX 78216 USA. [Perkins, Edward J.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Deng, Youping] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA. RP Zhang, CY (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA. EM chaoyang.zhang@usm.edu FU US Army Corps of Engineers Environmental Quality [W912HZ-08-2-0011]; NSF EPSCoR [EPS-0903787] FX This work was supported by the US Army Corps of Engineers Environmental Quality Program under contract #W912HZ-08-2-0011 and the NSF EPSCoR project "Modeling and Simulation of Complex Systems" (NSF #EPS-0903787). Permission was granted by the Chief of Engineers to publish this information. NR 18 TC 5 Z9 5 U1 0 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD DEC 23 PY 2011 VL 5 SU 3 AR S3 DI 10.1186/1752-0509-5-S3-S3 PG 6 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 929FL UT WOS:000303046600004 PM 22784622 ER PT J AU Taylor, DE Runge, K Cory, MG Burns, DS Vasey, JL Hearn, JD Henley, MV AF Taylor, DeCarlos E. Runge, Keith Cory, Marshall G. Burns, Douglas S. Vasey, Joseph L. Hearn, John D. Henley, Michael V. TI Binding of Small Molecules to a Silica Surface: Comparing Experimental and Theoretical Results SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID AB-INITIO; ISOLATED HYDROXYL; PERIODIC MODEL; ADSORPTION; B3-LYP; WATER; NH3 AB A multiscale method for systematically generating predictive models for probe - surface interactions and its independent experimental verification is described. The interaction of three probe molecules (H2O, NH3, and NO) with silica was studied using experiment, theoretical quantum chemistry, and molecular dynamics calculations. Quantum chemical (QC) methods were used to compute binding enthalpies and vibrational (infrared, IR) spectra of molecule surface pairs for three unique surface silanol sites. The probe-surface IR spectral shifts induced by the interaction of the probe molecules with the surface silanol sites were also computed and compared to experiment. The computed IR results are comparable to those of experiment and (a) verified that the surface that has been created using simulation is indeed similar to the experimental surface and (b) shed insight into the underlying physical process leading to the observed shifts. The theoretically determined enthalpies of adsorption (Delta H-ads) compared well with experiment falling within the uncertainty of those measured using inverse gas chromatography. For water, Delta H-ads,(350K) = -13.5 kcal/mol (calculated) versus -13.6 +/- 2.8 kcal/mol (experimental, 330 K < T-expt < 370K). For ammonia, Delta H-ads,H-353K = -15.2 kcal/mol (calculated) versus 12.7 +/- 2.9 kcal/mol (experimental, 323 K < T-expt < 383K). Finally, for nitric oxide, Delta H-ads,H-253K = -4.23 kcal/mol (calculated) versus 4.03 +/- 0.35 kcal/mol (experimental, 243 K < T-xpt < 263 K). C1 [Runge, Keith] BWD Associates LLC, Gainesville, FL 32653 USA. [Cory, Marshall G.; Burns, Douglas S.; Vasey, Joseph L.] ENSCO Inc, Melbourne, FL 32940 USA. [Hearn, John D.; Henley, Michael V.] US AFRL RXQL, Tyndall AFB, FL 32403 USA. [Taylor, DeCarlos E.] USA, Res Lab, Weap & Mat Res Directorate RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA. RP Runge, K (reprint author), BWD Associates LLC, 2901 NW 54th Ave, Gainesville, FL 32653 USA. EM krunge@bellsouth.net FU Defense Threat Reduction Agency (DTRA) [HDTRA1-07-C-0095] FX This work was supported by the Defense Threat Reduction Agency (DTRA) (contract #: HDTRA1-07-C-0095). While this research has been funded by the agency, the results and content of this publication do not necessarily reflect the views and opinions of the funding agency. NR 35 TC 5 Z9 5 U1 2 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD DEC 22 PY 2011 VL 115 IS 50 BP 24734 EP 24742 DI 10.1021/jp205479v PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 860KR UT WOS:000297947700039 ER PT J AU Pitisuttithum, P Rerks-Ngarm, S Bussaratid, V Dhitavat, J Maekanantawat, W Pungpak, S Suntharasamai, P Vanijanonta, S Nitayapan, S Kaewkungwal, J Benenson, M Morgan, P O'Connell, RJ Berenberg, J Gurunathan, S Francis, DP Paris, R Chiu, J Stablein, D Michael, NL Excler, JL Robb, ML Kim, JH AF Pitisuttithum, Punnee Rerks-Ngarm, Supachai Bussaratid, Valai Dhitavat, Jittima Maekanantawat, Wirach Pungpak, Swangjai Suntharasamai, Pravan Vanijanonta, Sirivan Nitayapan, Sorachai Kaewkungwal, Jaranit Benenson, Michael Morgan, Patricia O'Connell, Robert J. Berenberg, Jeffrey Gurunathan, Sanjay Francis, Donald P. Paris, Robert Chiu, Joseph Stablein, Donald Michael, Nelson L. Excler, Jean-Louis Robb, Merlin L. Kim, Jerome H. TI Safety and Reactogenicity of Canarypox ALVAC-HIV (vCP1521) and HIV-1 gp120 AIDSVAX B/E Vaccination in an Efficacy Trial in Thailand SO PLOS ONE LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; PRIME-BOOST IMMUNIZATION; IMMUNE-RESPONSES; ANTIRETROVIRAL THERAPY; SUBTYPE-E; T-CELLS; SMALLPOX VACCINATION; HIV-1-INFECTED WOMEN; CANDIDATE VACCINE; RECOMBINANT GP120 AB Background: A prime-boost vaccination regimen with ALVAC-HIV (vCP1521) administered intramuscularly at 0, 4, 12, and 24 weeks and gp120 AIDSVAX B/E at 12 and 24 weeks demonstrated modest efficacy of 31.2% for prevention of HIV acquisition in HIV-uninfected adults participating in a community-based efficacy trial in Thailand. Methodology/Principal Findings: Reactogenicity was recorded for 3 days following vaccination. Adverse events were monitored every 6 months for 3.5 years, during which pregnancy outcomes were recorded. Of the 16,402 volunteers, 69% of the participants reported an adverse event any time after the first dose. Only 32.9% experienced an AE within 30 days following any vaccination. Overall adverse event rates and attribution of relatedness did not differ between groups. The frequency of serious adverse events was similar in vaccine (14.3%) and placebo (14.9%) recipients (p = 0.33). None of the 160 deaths (85 in vaccine and 75 in placebo recipients, p = 0.43) was assessed as related to vaccine. The most common cause of death was trauma or traffic accident. Approximately 30% of female participants reported a pregnancy during the study. Abnormal pregnancy outcomes were experienced in 17.1% of vaccine and 14.6% (p = 0.13) of placebo recipients. When the conception occurred within 3 months (estimated) of a vaccination, the majority of these abnormal outcomes were spontaneous or elective abortions among 22.2% and 15.3% of vaccine and placebo pregnant recipients, respectively (p = 0.08). Local reactions occurred in 88.0% of vaccine and 61.0% of placebo recipients (p<0.001) and were more frequent after ALVAC-HIV than AIDSVAX B/E vaccination. Systemic reactions were more frequent in vaccine than placebo recipients (77.2% vs. 59.8%, p<0.001). Local and systemic reactions were mostly mild to moderate, resolving within 3 days. Conclusions/Significance: The ALVAC-HIV and AIDSVAX B/E vaccine regimen was found to be safe, well tolerated and suitable for potential large-scale use in Thailand. C1 [Pitisuttithum, Punnee; Bussaratid, Valai; Dhitavat, Jittima; Maekanantawat, Wirach; Pungpak, Swangjai; Suntharasamai, Pravan; Vanijanonta, Sirivan; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Bangkok, Thailand. [Nitayapan, Sorachai; Benenson, Michael; Morgan, Patricia] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [O'Connell, Robert J.; Michael, Nelson L.; Excler, Jean-Louis; Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. [Berenberg, Jeffrey] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. [Gurunathan, Sanjay] Sanofi Pasteur, Swiftwater, PA USA. [Francis, Donald P.] Global Solut Infect Dis, San Francisco, CA USA. [Paris, Robert] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Chiu, Joseph] NIAID, Div Aids, NIH, Bethesda, MD 20892 USA. [Stablein, Donald] EMMES Corp, Rockville, MD USA. RP Pitisuttithum, P (reprint author), Mahidol Univ, Fac Trop Med, Bangkok, Thailand. EM tmppt@mahidol.ac.th FU U.S. Army Medical Research and Materiel Command [Y1-AI-2642-12]; National Institute of Allergy and Infectious Diseases [W81XWH-07-2-0067]; Henry M. Jackson Foundation for the Advancement of Military Medicine; U.S. Department of Defense; National Institutes of Health, Bethesda, MD, USA; U.S. Military HIV Research Program, Rockville, MD, USA; Department for Disease Control, Bangkok, Thailand; Mahidol University, Bangkok, Thailand; RIMS, Global Solutions for Infectious Diseases, South San Francisco, CA, USA; EMMES Corporation, Rockville MD, USA; Sanofi Pasteur, Swiftwater, PA, USA; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand FX Supported in part by an Interagency Agreement (Y1-AI-2642-12) between the U.S. Army Medical Research and Materiel Command and the National Institute of Allergy and Infectious Diseases and by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Department of Defense. The U.S. Army was also involved in the planning, funding, execution and analysis of the trial; it was involved in both the preparation of the manuscript and the decision to publish. NIAID was involved in the planning and funding. Sanofi Pasteur provided the ALVAC-HIV vaccine, and Global Solutions for Infectious Diseases (VaxGen) provided the reagents for the immunogenicity assays. The manufacturers were full trial collaborators and were a part of the phase 3 trial steering committee.; We gratefully acknowledge and thank all the participants of the trial and the support rendered by National Institutes of Health, Bethesda, MD, USA; U.S. Military HIV Research Program, Rockville, MD, USA; Department for Disease Control, Bangkok, Thailand; Mahidol University, Bangkok, Thailand, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; RIMS, Global Solutions for Infectious Diseases, South San Francisco, CA, USA; EMMES Corporation, Rockville MD, USA; Sanofi Pasteur, Swiftwater, PA, USA. We thank Elizabeth Adams, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, for helpful comments. NR 60 TC 27 Z9 28 U1 1 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD DEC 21 PY 2011 VL 6 IS 12 AR e27837 DI 10.1371/journal.pone.0027837 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 876NF UT WOS:000299113600004 PM 22205930 ER PT J AU Hou, C Mayo, M AF Hou, Chen Mayo, Michael TI Pulmonary diffusional screening and the scaling laws of mammalian metabolic rates SO PHYSICAL REVIEW E LA English DT Article ID AIR-FILLED LOBES; RESPIRATORY SYSTEM; CAT LUNG; CAPACITY; ACINUS; DESIGN; LIFE; MORPHOMETRY; MORPHOLOGY; GEOMETRY AB Theoretical considerations suggest that the mammalian metabolic rate is linearly proportional to the surface areas of mitochondria, capillary, and alveolar membranes. However, the scaling exponents of these surface areas to themammals' body mass (approximately 0.9-1) are higher than exponents of the restingmetabolic rate (RMR) to body mass (approximately 0.75), although similar to the one of exercise metabolic rate (EMR); the underlying physiological cause of this mismatch remains unclear. The analysis presented here shows that discrepancies between the scaling exponents of RMR and the relevant surface areas may originate from, at least for the system of alveolar membranes in mammalian lungs, the facts that (i) not all of the surface area is involved in the gas exchange and (ii) that larger mammals host a smaller effective surface area that participates in the material exchange rate. A result of these facts is that lung surface areas unused at rest are activated under heavy breathing conditions (e.g., exercise), wherein larger mammals support larger activated surface areas that provide a higher capability to increase the gas-exchange rate, allowing for mammals to meet, for example, the high energetic demands of foraging and predation. C1 [Hou, Chen] Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO 65409 USA. [Mayo, Michael] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Hou, C (reprint author), Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO 65409 USA. EM michael.l.mayo@usace.army.mil OI Hou, Chen/0000-0002-3665-225X FU US Army's Environmental Quality and Installations FX This work was partially supported by the US Army's Environmental Quality and Installations 6.1 basic research program. We thank P. Pfeifer for insightful discussions and helpful advice. The Chief of Engineers approved this material for publication. NR 37 TC 1 Z9 1 U1 2 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2470-0045 EI 2470-0053 J9 PHYS REV E JI Phys. Rev. E PD DEC 20 PY 2011 VL 84 IS 6 AR 061915 DI 10.1103/PhysRevE.84.061915 PN 1 PG 6 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 870LA UT WOS:000298669600011 PM 22304124 ER PT J AU Zeitlin, L Pettitt, J Scully, C Bohorova, N Kim, D Pauly, M Hiatt, A Ngo, L Steinkellner, H Whaley, KJ Olinger, GG AF Zeitlin, Larry Pettitt, James Scully, Corinne Bohorova, Natasha Kim, Do Pauly, Michael Hiatt, Andrew Long Ngo Steinkellner, Herta Whaley, Kevin J. Olinger, Gene G. TI Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE passive immunization; antibody glycosylation; antibody-dependent cellular cytotoxicity; antiviral ID TRANSIENT EXPRESSION; BIOLOGICAL-ACTIVITY; HEMORRHAGIC-FEVER; PLANTS; IGG1; GLYCOSYLATION; MODEL; OLIGOSACCHARIDES; AGROBACTERIUM; OPTIMIZATION AB No countermeasures currently exist for the prevention or treatment of the severe sequelae of Filovirus (such as Ebola virus; EBOV) infection. To overcome this limitation in our biodefense preparedness, we have designed monoclonal antibodies (mAbs) which could be used in humans as immunoprotectants for EBOV, starting with a murine mAb (13F6) that recognizes the heavily glycosylated mucin-like domain of the virion-attached glycoprotein (GP). Point mutations were introduced into the variable region of the murine mAb to remove predicted human T-cell epitopes, and the variable regions joined to human constant regions to generate a mAb (h-13F6) appropriate for development for human use. We have evaluated the efficacy of three variants of h-13F6 carrying different glycosylation patterns in a lethal mouse EBOV challenge model. The pattern of glycosylation of the various mAbs was found to correlate to level of protection, with aglycosylated h-13F6 providing the least potent efficacy (ED(50) = 33 mu g). A version with typical heterogenous mammalian glycoforms (ED(50) = 11 mu g) had similar potency to the original murine mAb. However, h-13F6 carrying complex N-glycosylation lacking core fucose exhibited superior potency (ED(50) = 3 mu g). Binding studies using Fc gamma receptors revealed enhanced binding of nonfucosylated h-13F6 to mouse and human Fc gamma RIII. Together the results indicate the presence of Fc N-glycans enhances the protective efficacy of h-13F6, and that mAbs manufactured with uniform glycosylation and a higher potency glycoform offer promise as biodefense therapeutics. C1 [Zeitlin, Larry; Bohorova, Natasha; Kim, Do; Pauly, Michael; Hiatt, Andrew; Whaley, Kevin J.] Mapp Biopharmaceut, San Diego, CA 92121 USA. [Pettitt, James; Scully, Corinne; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Dept Virol, Frederick, MD 21702 USA. [Long Ngo] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA. [Steinkellner, Herta] Univ Nat Resources & Life Sci, Dept Appl Genet & Cell Biol, A-1190 Vienna, Austria. RP Zeitlin, L (reprint author), Mapp Biopharmaceut, San Diego, CA 92121 USA. EM larry.zeitlin@mappbio.com RI Steinkellner, Herta/N-4267-2016; OI Steinkellner, Herta/0000-0003-4823-1505; Olinger, Gene/0000-0001-7338-0292 FU National Institute of Allergy and Infectious Diseases [AI61270, AI 72915]; Department of Defense [DAMD 17-02-2-0015]; Defense Threat Reduction Agency [4.10007-08-RD-B] FX We thank Dr. Yuri Gleba for providing access to the magnICON expression system, Dr. Ognian Bohorov for comments on the manuscript, and Drs. Friedrich Altmann and Johannes Stadlmann for glycan analyses. This work was supported by National Institute of Allergy and Infectious Diseases Grants AI61270 and AI 72915 and Department of Defense Grant DAMD 17-02-2-0015, and partially supported by Defense Threat Reduction Agency Grant 4.10007-08-RD-B. NR 38 TC 69 Z9 74 U1 0 U2 17 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC 20 PY 2011 VL 108 IS 51 BP 20690 EP 20694 DI 10.1073/pnas.1108360108 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 865CW UT WOS:000298289400085 PM 22143789 ER PT J AU Phoolcharoen, W Dye, JM Kilbourne, J Piensook, K Pratt, WD Arntzen, CJ Chen, Q Mason, HS Herbst-Kralovetz, MM AF Phoolcharoen, Waranyoo Dye, John M. Kilbourne, Jacquelyn Piensook, Khanrat Pratt, William D. Arntzen, Charles J. Chen, Qiang Mason, Hugh S. Herbst-Kralovetz, Melissa M. TI A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Ebola vaccine; Ebola glycoprotein; protective antibody; antibody-antigen fusion; immunopotentiator ID STRANDED-RNA POLY(I-C); DNA REPLICON SYSTEM; NONHUMAN-PRIMATES; IMMUNE-COMPLEX; MARBURG VIRUS; MONOCLONAL-ANTIBODIES; HEMORRHAGIC-FEVER; TRANSGENIC PLANTS; T-CELLS; IN-VIVO AB Ebola hemorrhagic fever is an acute and often deadly disease caused by Ebola virus (EBOV). The possible intentional use of this virus against human populations has led to design of vaccines that could be incorporated into a national stockpile for biological threat reduction. We have evaluated the immunogenicity and efficacy of an EBOV vaccine candidate in which the viral surface glycoprotein is biomanufactured as a fusion to a monoclonal antibody that recognizes an epitope in glycoprotein, resulting in the production of Ebola immune complexes (EICs). Although antigen-antibody immune complexes are known to be efficiently processed and presented to immune effector cells, we found that codelivery of the EIC with Toll-like receptor agonists elicited a more robust antibody response in mice than did EIC alone. Among the compounds tested, polyinosinic: polycytidylic acid (PIC, a Toll-like receptor 3 agonist) was highly effective as an adjuvant agent. After vaccinating mice with EIC plus PIC, 80% of the animals were protected against a lethal challenge with live EBOV (30,000 LD(50) of mouse adapted virus). Surviving animals showed a mixed Th1/Th2 response to the antigen, suggesting this may be important for protection. Survival after vaccination with EIC plus PIC was statistically equivalent to that achieved with an alternative viral vector vaccine candidate reported in the literature. Because nonreplicating subunit vaccines offer the possibility of formulation for cost-effective, long-term storage in biothreat reduction repositories, EIC is an attractive option for public health defense measures. C1 [Phoolcharoen, Waranyoo; Kilbourne, Jacquelyn; Piensook, Khanrat; Arntzen, Charles J.; Mason, Hugh S.; Herbst-Kralovetz, Melissa M.] Arizona State Univ, Ctr Infect Dis & Vaccinol, Biodesign Inst, Tempe, AZ 85287 USA. [Phoolcharoen, Waranyoo; Arntzen, Charles J.; Mason, Hugh S.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA. [Dye, John M.; Pratt, William D.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Chen, Qiang] Arizona State Univ, Coll Technol & Innovat, Mesa, AZ 85212 USA. [Herbst-Kralovetz, Melissa M.] Univ Arizona, Coll Med Phoenix, Dept Basic Med Sci, Phoenix, AZ 85004 USA. RP Arntzen, CJ (reprint author), Arizona State Univ, Ctr Infect Dis & Vaccinol, Biodesign Inst, Tempe, AZ 85287 USA. EM charles.arntzen@asu.edu; mherbst1@email.arizona.edu OI chen, qiang/0000-0003-1498-7013; Herbst-Kralovetz, Melissa/0000-0002-8540-5917 FU National Institutes of Health [5U01AI061253-02] FX The authors thank Mapp Biopharmaceutical (San Diego, CA) for providing the facilities for protein preparation. This work was supported by National Institutes of Health Grant 5U01AI061253-02. NR 32 TC 27 Z9 29 U1 3 U2 29 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD DEC 20 PY 2011 VL 108 IS 51 BP 20695 EP 20700 DI 10.1073/pnas.1117715108 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 865CW UT WOS:000298289400086 PM 22143779 ER PT J AU Steenbergen, EH Connelly, BC Metcalfe, GD Shen, H Wraback, M Lubyshev, D Qiu, Y Fastenau, JM Liu, AWK Elhamri, S Cellek, OO Zhang, YH AF Steenbergen, E. H. Connelly, B. C. Metcalfe, G. D. Shen, H. Wraback, M. Lubyshev, D. Qiu, Y. Fastenau, J. M. Liu, A. W. K. Elhamri, S. Cellek, O. O. Zhang, Y. -H. TI Significantly improved minority carrier lifetime observed in a long-wavelength infrared III-V type-II superlattice comprised of InAs/InAsSb SO APPLIED PHYSICS LETTERS LA English DT Article AB Time-resolved photoluminescence measurements reveal a minority carrier lifetime of >412 ns at 77K under low excitation for a long-wavelength infrared InAs/InAs(0.72)Sb(0.28) type-II superlattice (T2SL). This lifetime represents an order-of-magnitude increase in the minority carrier lifetime over previously reported lifetimes in long-wavelength infrared InAs/Ga(1-x)In(x)Sb T2SLs. The considerably longer lifetime is attributed to a reduction of non-radiative recombination centers with the removal of Ga from the superlattice structure. This lifetime improvement may enable background limited T2SL long-wavelength infrared photodetectors at higher operating temperatures. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3671398] C1 [Steenbergen, E. H.; Cellek, O. O.; Zhang, Y. -H.] Arizona State Univ, Ctr Photon Innovat, Tempe, AZ 85287 USA. [Steenbergen, E. H.; Cellek, O. O.; Zhang, Y. -H.] Arizona State Univ, Sch Elect Comp & Energy Engn, Tempe, AZ 85287 USA. [Connelly, B. C.; Metcalfe, G. D.; Shen, H.; Wraback, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Lubyshev, D.; Qiu, Y.; Fastenau, J. M.; Liu, A. W. K.] IQE Inc, Bethlehem, PA 18015 USA. [Elhamri, S.] Univ Dayton, Dept Phys, Dayton, OH 45469 USA. RP Steenbergen, EH (reprint author), Arizona State Univ, Ctr Photon Innovat, Tempe, AZ 85287 USA. EM Elizabeth.Steenbergen@asu.edu FU U. S. Army Research Laboratory; U. S. Army Research Office MURI [W911NF-10-1-0524]; AFOSR [FA9550-10-1-0129]; DOD SMART; ARCS; SFAz; ASU Office of the Vice-President for Research and Economic Affairs FX The authors acknowledge funding by the U. S. Army Research Laboratory and the U. S. Army Research Office MURI program under Grant No. W911NF-10-1-0524 and by the AFOSR under Grant No. FA9550-10-1-0129. E.H.S. appreciates the DOD SMART, ARCS, and SFAz scholarships and acknowledges funding from the ASU Office of the Vice-President for Research and Economic Affairs, the Graduate Research Support Program, and the Graduate College. NR 17 TC 90 Z9 92 U1 5 U2 58 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 19 PY 2011 VL 99 IS 25 AR 251110 DI 10.1063/1.3671398 PG 3 WC Physics, Applied SC Physics GA 875LO UT WOS:000299031600010 ER PT J AU Khan, FA Campbell, AJ Hoyt, B Herdman, C Ku, T Thangavelu, S Gordon, RK AF Khan, Farhat A. Campbell, Amy J. Hoyt, Benjamin Herdman, Christine Ku, Therese Thangavelu, Sonia Gordon, Richard K. TI Oxidative mechanisms for the biotransformation of 1-methyl-1,6-dihydropyridine-2-carbaldoxime to pralidoxime chloride SO LIFE SCIENCES LA English DT Article DE Pralidoxime chloride; 1-Methyl-1,6-dihydropyridine-2-carbaldoxime; Acetylcholinesterase; Blood brain barrier; NADPH oxidase; Riboflavin; Pro-drug ID BLOOD-BRAIN-BARRIER; NADPH OXIDASE; GUINEA-PIGS; CHOLINESTERASE REACTIVATORS; NERVE AGENTS; IN-VITRO; OXIMES; INHIBITION; RAT; ACETYLCHOLINESTERASE AB Aims: Due to pralidoxime chloride's (2-PAM) positive charge, it's penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. The results of CNS inhibited AChE are seizures. Pro-2-PAM (1-methyl-1,6-dihydropyridine-2-carbaldoxime), a pro-drug of 2-PAM, due to higher hydrophobicity, penetrates the BBB better but must be oxidized to 2-PAM, the active form of the oxime to reactivate CNS AChE in order to abrogate seizures. In this study, we characterize the in vivo mechanism of pro-2-PAM oxidation. Main methods: A high pressure liquid chromatography (HPLC) assay was developed to quantify the conversion of pro-2-PAM to 2-PAM. NADPH oxidase activity was measured by a photo-luminescence assay using lucigenin substrate. Upon analysis, the rate of NADPH induced oxidation suggested that an alternate mechanism may be involved. Therefore, various enzyme co-factors of oxidation-reduction enzyme systems were evaluated, including nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), flavin adenine dinucleotide (FAD), riboflavin 5'-phosphate (FMN), and riboflavin. Next, a spectrophotometric assay was developed to measure the conversion of pro-2-PAM to 2-PAM in the presence of riboflavin. Key findings: In guinea pig brain homogenate, diphenyleneiodonium (DPI), a specific NADPH oxidase inhibitor, reduced pro-2-PAM to 2-PAM conversion to less than 25%. In contrast, riboflavin, FAD, and FMN rapidly oxidized all pro-2-PAM to 2-PAM in an in vitro assay. Riboflavin oxidized pro-2-PAM reactivated diisopropylfluorophosphate (DFP) inhibited AChE. Significance: The present study shows that pro-2-PAM was rapidly oxidized by riboflavin to 2-PAM, which reactivated organophosphate (OP)-inhibited AChE. (C) 2011 Published by Elsevier Inc. C1 [Khan, Farhat A.; Hoyt, Benjamin; Herdman, Christine; Ku, Therese; Thangavelu, Sonia; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, Silver Spring, MD 20910 USA. [Campbell, Amy J.] Geneva Fdn, Lakewood, WA 98496 USA. RP Khan, FA (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM farhat.khan@amedd.army.mil OI Herdman, Christine/0000-0001-9019-4491 FU NIH [U01NS058166] FX We thank Julian R. Haigh, Ph.D. and Shahza Somerville, Ph.D. for critical reading of this manuscript. This work was supported by NIH CounterACT U01NS058166. The opinions or assertions contained herein are private views of the authors, and are not to be construed as official views of the Department of the Army or the Department of Defense. NR 52 TC 2 Z9 3 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD DEC 19 PY 2011 VL 89 IS 25-26 BP 911 EP 917 DI 10.1016/j.lfs.2011.09.019 PG 7 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 859RZ UT WOS:000297894800001 PM 21989207 ER PT J AU Cole, MW Toonen, RC Ivill, M Hirsch, SG Ngo, E Hubbard, C AF Cole, M. W. Toonen, R. C. Ivill, M. Hirsch, S. G. Ngo, E. Hubbard, C. TI Ultraviolet assisted processing: A unique approach to mitigate oxygen vacancies and attain low loss highly tunable Ba0.60Sr0.40TiO3 thin films SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PULSED-LASER DEPOSITION; MICROWAVE APPLICATIONS; DIELECTRIC RESPONSE; DEVICE APPLICATIONS; TEMPERATURE; CRYSTALLIZATION; HETEROSTRUCTURES; DEPENDENCE; FREQUENCY; VARACTORS AB Isothermal (700 degrees C) ultraviolet annealing (UVA) processing of crystallized Ba0.60Sr0.40TiO3 (BST) thin films for exposure times up to 225 min films has been studied. The BST films, grown on PtSi wafers via the metalorganic solution deposition (MOSD) technique, were crystallized via conventional furnace annealing (CFA) prior to UVA treatment, and the effects of UV annealing time on the structural, dielectric, and insulation properties were evaluated. The experimental results demonstrated significantly improved structural, dielectric, and insulation properties for the UVA films. Specifically, lattice parameter contraction (toward that of bulk BST60/40) and a 20% reduction in loss were observed for the UVA treated films with respect to the CFA/control film. Leakage current characteristics were found to be the most sensitive characterization technique to access material property modification as a result of UVA exposure time. Specifically, the 225 min UVA exposure time resulted in a three-order of magnitude reduction in leakage current density compared to the CFA film, and the lowest value observed was 1.06 x 10(-7) A/cm(2) at E 300 kV/cm. The useable tunability (tunability value at the maximum acceptable leakage current, 500 pA) was found to be elevated by a factor of two with respect to that of the CFA/control BST film (52.31%/UVA film vs. 18.5%/control film). It is suggested that the improved material properties are due to the mitigation of unwanted oxygen vacancies within the film after UV-annealing. A mechanistic model is presented and discussed. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3671642] C1 [Cole, M. W.; Toonen, R. C.; Ivill, M.; Hirsch, S. G.; Ngo, E.; Hubbard, C.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Cole, MW (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM melanie.w.cole.civ@mail.mil FU Directors Research Initiative (DRI); Army Research Laboratory FX The authors gratefully acknowledge the support of the director of the Army Research Laboratory for funding this research under the Directors Research Initiative (DRI) Award. NR 49 TC 11 Z9 11 U1 0 U2 26 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 2011 VL 110 IS 12 AR 124105 DI 10.1063/1.3671642 PG 7 WC Physics, Applied SC Physics GA 869ZV UT WOS:000298639800088 ER PT J AU Petrie, J Viehland, D Gray, D Mandal, S Sreenivasulu, G Srinivasan, G Edelstein, AS AF Petrie, Jonathan Viehland, Dwight Gray, David Mandal, Sanjay Sreenivasulu, Gollapudi Srinivasan, Gopalan Edelstein, Alan S. TI Enhancing the sensitivity of magnetoelectric sensors by increasing the operating frequency SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB We present a field modulation technique that increases the operating frequency of magnetoelectric ( ME) sensors so that it can match the mechanical resonance frequency of the sensor. This not only improves the sensitivity but also reduces the effect of 1/f noise that is inherent at low frequencies. The technique, which is shown to apply to both symmetric and asymmetric ME sensors, relies on the strong, nonlinear magnetic field dependence of the magnetostriction. The combination of a lower 1/f noise and enhanced response at resonance has increased the signal to noise ratio of a symmetric sensor by two orders of magnitude. The detection limit of this sensor was lowered from 90 to 7 pT/root Hz at 1Hz in a magnetically unshielded environment. (C) 2011 American Institute of Physics. [doi:10.1063/1.3668752] C1 [Petrie, Jonathan; Edelstein, Alan S.] USA, Res Lab, Adelphi, MD 20783 USA. [Viehland, Dwight; Gray, David] Virginia Tech Univ, Blacksburg, VA 24060 USA. [Mandal, Sanjay; Sreenivasulu, Gollapudi; Srinivasan, Gopalan] Oakland Univ, Rochester, MI 48309 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM alan.s.edelstein.civ@mail.mil OI Gollapudi, Sreenivasulu/0000-0002-6136-7119 FU Defense Advanced Research Projects Agency (DARPA) FX The support for this project under the Defense Advanced Research Projects Agency (DARPA) Uncooled Magnetic Sensor, Heterostructural Uncooled Magnetic Sensors (HUMS) program is gratefully acknowledged. NR 12 TC 15 Z9 15 U1 0 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 2011 VL 110 IS 12 AR 124506 DI 10.1063/1.3668752 PG 4 WC Physics, Applied SC Physics GA 869ZV UT WOS:000298639800124 ER PT J AU Panigrahi, SK Yuan, W Mishra, RS DeLorme, R Davis, B Howell, RA Cho, K AF Panigrahi, S. K. Yuan, W. Mishra, R. S. DeLorme, R. Davis, B. Howell, R. A. Cho, K. TI A study on the combined effect of forging and aging in Mg-Y-RE alloy SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Magnesium alloys; Mechanical properties; Fracture behavior; Age hardening ID MECHANICAL-PROPERTIES; MAGNESIUM ALLOYS; THERMOMECHANICAL TREATMENT; HOT DEFORMATION; COLD WORK; PRECIPITATION; SUPERPLASTICITY; STRENGTH; TEXTURE; SLIP AB The combined effect of forging and aging on microstructural evolution and mechanical properties of a Mg-Y-RE alloy was studied in the present work by employing hardness measurements, tensile tests, optical microscopy (OM), scanning electron microscopy (SEM) and electron back scattered diffraction (EBSD) analysis. The -F temper treated bulk Mg-Y-RE alloy samples were subjected to forging for microstructural refinement and subsequent aging to maximize the strength-ductility combination. The forged samples combined with peak aging treatment (60 hat 180 degrees C) exhibited an excellent combination of high strength (388 MPa) and high ductility (23%). The combined effect of grain refinement, work hardening, precipitation strengthening and recovery is responsible for the simultaneous improvement of both strength and ductility. A comparative study of age hardening response of forged samples and as received samples showed higher hardenability in forged samples. (C) 2011 Elsevier B.V. All rights reserved. C1 [Panigrahi, S. K.; Yuan, W.; Mishra, R. S.] Missouri Univ Sci & Technol, Ctr Frict Stir Proc, Rolla, MO 65409 USA. [Panigrahi, S. K.; Yuan, W.; Mishra, R. S.] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. [DeLorme, R.; Davis, B.] Magnesium Elektron N Amer Inc, Madison, IL 62060 USA. [Howell, R. A.; Cho, K.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Mishra, RS (reprint author), Missouri Univ Sci & Technol, Ctr Frict Stir Proc, Rolla, MO 65409 USA. EM rsmishra@mst.edu RI Mishra, Rajiv/A-7985-2009 OI Mishra, Rajiv/0000-0002-1699-0614 FU U.S. Army Research Laboratory [W911NF-07-2-0073] FX Research was sponsored by U.S. Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-07-2-0073. The views, opinions, and conclusions made in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. NR 42 TC 23 Z9 23 U1 2 U2 22 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD DEC 15 PY 2011 VL 530 BP 28 EP 35 DI 10.1016/j.msea.2011.08.065 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 865KZ UT WOS:000298311100005 ER PT J AU Vuyovich, C Jacobs, JM AF Vuyovich, Carrie Jacobs, Jennifer M. TI Snowpack and runoff generation using AMSR-E passive microwave observations in the Upper Helmand Watershed, Afghanistan SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE Snow; AMSR-E; Runoff; Afghanistan; Microwave remote sensing ID NORTHERN GREAT-PLAINS; REMOTE-SENSING DATA; IN-SITU; HYDROLOGY MODEL; EQUIVALENT; SNOWMELT; COVER; RIVER; BASIN; CANADA AB Passive microwave estimates of snow water equivalent (SWE) were examined to determine their usefulness for evaluating water resources in the remote Upper Helmand Watershed, central Afghanistan. SWE estimates from the Advanced Microwave Scanning Radiometer Earth Observing System (AMSR-E) and the Special Sensor Microwave/Imager (SSM/I) passive microwave data were analyzed for six winter seasons, 2004-2009. A second, independent estimate of SWE was calculated for these same time periods using a hydrologic model of the watershed with a temperature index snow model driven using the Tropical Rainfall Measuring Mission (TRMM) gridded estimates of precipitation. The results demonstrate that passive microwave SWE values from SSM/I and AMSR-E are comparable. The AMSR-E sensor had improved performance in the early winter and late spring, which suggests that AMSR-E is better at detecting shallow snowpacks than SSM/I. The timing and magnitude of SWE values from the snow model and the passive microwave observations were sometimes similar with a correlation of 0.53 and accuracy between 55 and 62%. However, the modeled SWE was much lower than the AMSR-E SWE during two winter seasons in which TRMM data estimated lower than normal precipitation. Modeled runoff and reservoir storage predictions improved significantly when peak AMSR-E SWE values were used to update the snow model state during these periods. Rapid decreases in passive microwave SWE during precipitation events were also well aligned with flood flows that increased base flows by 170 and 940%. This finding supports previous northern latitude studies which indicate that the passive microwave signal's lack of scattering can be used to detect snow melt. The current study's extension to rain on snow events suggests an opportunity for added value for flood forecasting. Published by Elsevier Inc. C1 [Vuyovich, Carrie] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Jacobs, Jennifer M.] Univ New Hampshire, Durham, NH 03824 USA. RP Vuyovich, C (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Carrie.M.Vuyovich@usace.army.mil FU US Army Corps of Engineers; U.S. Army Engineer Research and Development Center's Cold Regions Research and Engineering Laboratory FX This work was supported by the US Army Corps of Engineers and the U.S. Army Engineer Research and Development Center's Cold Regions Research and Engineering Laboratory. We gratefully acknowledge John Hazelton (USACE) for providing essential data at the Kajakai Reservoir, Stephen Newman (USACE) for processing the SCA images, Mary Jo Brodzik (NSIDC) for providing the SSM/I data, and Dr. Steven Daly and Dr. William Scharffenberg for helping with the HEC-HMS snow model. We would also like to thank the three anonymous reviewers whose suggestions greatly improved the paper. NR 51 TC 12 Z9 14 U1 2 U2 25 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD DEC 15 PY 2011 VL 115 IS 12 BP 3313 EP 3321 DI 10.1016/j.rse.2011.07.014 PG 9 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 865LB UT WOS:000298311300029 ER PT J AU Li, B Cardinale, SC Butler, MM Pai, R Nuss, JE Peet, NP Bavari, S Bowlin, TL AF Li, Bing Cardinale, Steven C. Butler, Michelle M. Pai, Ramdas Nuss, Jonathan E. Peet, Norton P. Bavari, Sina Bowlin, Terry L. TI Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors SO BIOORGANIC & MEDICINAL CHEMISTRY LA English DT Article DE Botulinum neurotoxin serotype A; Benzimidazole acrylonitrile; Structure-activity relationships; Molecular modeling; Time-dependent inhibition ID SMALL-MOLECULE INHIBITORS; TOXIN TYPE-A; LIGHT-CHAIN; ZINC ENDOPEPTIDASE; MEDICAL ASPECTS; IDENTIFICATION; PROTEASE; PHARMACOPHORE; PROTEOLYSIS; CHEMISTRY AB Botulinum neurotoxins (BoNTs) are the most lethal of biological substances, and are categorized as class A biothreat agents by the Centers for Disease Control and Prevention. There are currently no drugs to treat the deadly flaccid paralysis resulting from BoNT intoxication. Among the seven BoNT serotypes, the development of therapeutics to counter BoNT/A is a priority (due to its long half-life in the neuronal cytosol and its ease of production). In this regard, the BoNT/A enzyme light chain (LC) component, a zinc metalloprotease responsible for the intracellular cleavage of synaptosomal-associated protein of 25 kDa, is a desirable target for developing post-BoNT/A intoxication rescue therapeutics. In an earlier study, we reported the high throughput screening of a library containing 70,000 compounds, and uncovered a novel class of benzimidazole acrylonitrile-based BoNT/A LC inhibitors. Herein, we present both structure-activity relationships and a proposed mechanism of action for this novel inhibitor chemotype. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Li, Bing; Cardinale, Steven C.; Butler, Michelle M.; Pai, Ramdas; Peet, Norton P.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA. [Nuss, Jonathan E.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Li, B (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA. EM bli@microbiotix.com FU National Institutes of Health/National Institute of Allergy and Infectious Diseases [5U01AI070430] FX This work was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases (5U01AI070430). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services. The authors thank Dr. James C. Burnett for helpful discussions and Dr. Donald T. Moir for assistance with the kinetic analyses. The authors thank CreaGen Biosciences, Inc., for the preparation of starting material, for example, 2-(1H-indol-2-yl)acetonitrile (6) and for the scale-up of compound 14a. NR 58 TC 10 Z9 10 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0968-0896 J9 BIOORGAN MED CHEM JI Bioorg. Med. Chem. PD DEC 15 PY 2011 VL 19 IS 24 BP 7338 EP 7348 DI 10.1016/j.bmc.2011.10.062 PG 11 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry GA 859ES UT WOS:000297860100003 PM 22082667 ER PT J AU Bekhash, A Hooke, JA Chen, Y Kovatich, AJ Kvecher, L Mural, RJ Shriver, CD Hu, H AF Bekhash, A. Hooke, J. A. Chen, Y. Kovatich, A. J. Kvecher, L. Mural, R. J. Shriver, C. D. Hu, H. TI Fibroadenomatoid Changes Have a Higher Occurrence Rate in Middle-Aged Benign Breast Disease Patients with the Trend Retained in Cancer Patients. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Bekhash, A.; Hooke, J. A.; Chen, Y.; Kovatich, A. J.; Kvecher, L.; Mural, R. J.; Shriver, C. D.; Hu, H.] Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. MDR Global Syst LLC, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P1-03-06 DI 10.1158/0008-5472.SABCS11-P1-03-06 PG 2 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800355 ER PT J AU Bekhash, A Kovatich, AJ Chen, Y Hooke, JA Kvecher, L Mural, RJ Shriver, CD Hu, H AF Bekhash, A. Kovatich, A. J. Chen, Y. Hooke, J. A. Kvecher, L. Mural, R. J. Shriver, C. D. Hu, H. TI Fibrocystic Changes Have Different Age-Dependent Patterns in Benign, In Situ, and Invasive Breast Cancer Patients. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Bekhash, A.; Kovatich, A. J.; Chen, Y.; Hooke, J. A.; Kvecher, L.; Mural, R. J.; Shriver, C. D.; Hu, H.] Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. MDR Global Syst LLC, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P1-03-05 DI 10.1158/0008-5472.SABCS11-P1-03-05 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800354 ER PT J AU Ellsworth, DL Croft, DT Field, LA Deyarmin, B Kane, J Ellsworth, RE Hooke, JA Shriver, CD AF Ellsworth, D. L. Croft, D. T. Field, L. A. Deyarmin, B. Kane, J. Ellsworth, R. E. Hooke, J. A. Shriver, C. D. TI Congruence between Patterns of microRNA Expression and Histologic Grading of Invasive Breast Carcinomas. SO CANCER RESEARCH LA English DT Meeting Abstract C1 Windber Res Inst, Windber, PA USA. Henry M Jackson Fdn, Rockville, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P3-03-03 DI 10.1158/0008-5472.SABCS11-P3-03-03 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699801227 ER PT J AU Ellsworth, RE Valente, AL Kane, JL Shriver, CD AF Ellsworth, R. E. Valente, A. L. Kane, J. L. Shriver, C. D. TI The Effect of Breastfeeding on Molecular Characteristics of Invasive Breast Cancer. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ellsworth, R. E.; Valente, A. L.; Kane, J. L.; Shriver, C. D.] Jackson Fdn, Windber, PA USA. Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P5-05-03 DI 10.1158/0008-5472.SABCS11-P5-05-03 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699802209 ER PT J AU Ellsworth, RE Valente, AL Kane, JL Ellsworth, DL Shriver, CD AF Ellsworth, R. E. Valente, A. L. Kane, J. L. Ellsworth, D. L. Shriver, C. D. TI Gene Expression Alterations in the Lymph Node Microenvironment in Response to Successful Metastatic Colonization. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ellsworth, R. E.; Valente, A. L.; Kane, J. L.; Ellsworth, D. L.; Shriver, C. D.] Henry M Jackson Fdn, Windber, PA USA. Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P2-01-09 DI 10.1158/0008-5472.SABCS11-P2-01-09 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699801027 ER PT J AU Ellsworth, RE Croft, DT Ellsworth, DL Shriver, CD AF Ellsworth, R. E. Croft, D. T. Ellsworth, D. L. Shriver, C. D. TI Effect of Obesity on Gene Expression in Invasive Breast Tumors. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Ellsworth, R. E.; Croft, D. T.; Ellsworth, D. L.; Shriver, C. D.] Henry M Jackson Fdn, Windber, PA USA. Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P1-09-01 DI 10.1158/0008-5472.SABCS11-P1-09-01 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800144 ER PT J AU Hale, DF Perez, S Sears, AK Clifton, GT Vreeland, TJ Holmes, JP Ardavanis, A Pistamaltzian, N Reilias, G Ponniah, S Papamichail, M Peoples, GE Mittendorf, EA AF Hale, D. F. Perez, S. Sears, A. K. Clifton, G. T. Vreeland, T. J. Holmes, J. P. Ardavanis, A. Pistamaltzian, N. Reilias, G. Ponniah, S. Papamichail, M. Peoples, G. E. Mittendorf, E. A. TI An Update of a Phase II Trial of the HER2 Peptide AE37 Vaccine in Breast Cancer Patients To Prevent Recurrence SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Hale, D. F.; Perez, S.; Sears, A. K.; Clifton, G. T.; Vreeland, T. J.; Holmes, J. P.; Ardavanis, A.; Pistamaltzian, N.; Reilias, G.; Ponniah, S.; Papamichail, M.; Peoples, G. E.; Mittendorf, E. A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Hale, D. F.; Perez, S.; Sears, A. K.; Clifton, G. T.; Vreeland, T. J.; Holmes, J. P.; Ardavanis, A.; Pistamaltzian, N.; Reilias, G.; Ponniah, S.; Papamichail, M.; Peoples, G. E.; Mittendorf, E. A.] St Savas Canc Hosp, Athens, Greece. [Hale, D. F.; Perez, S.; Sears, A. K.; Clifton, G. T.; Vreeland, T. J.; Holmes, J. P.; Ardavanis, A.; Pistamaltzian, N.; Reilias, G.; Ponniah, S.; Papamichail, M.; Peoples, G. E.; Mittendorf, E. A.] Naval Med Ctr San Diego, San Diego, CA USA. [Hale, D. F.; Perez, S.; Sears, A. K.; Clifton, G. T.; Vreeland, T. J.; Holmes, J. P.; Ardavanis, A.; Pistamaltzian, N.; Reilias, G.; Ponniah, S.; Papamichail, M.; Peoples, G. E.; Mittendorf, E. A.] Uniformed Serv Univ Hlth Sci, USMCI, Bethesda, MD 20814 USA. [Hale, D. F.; Perez, S.; Sears, A. K.; Clifton, G. T.; Vreeland, T. J.; Holmes, J. P.; Ardavanis, A.; Pistamaltzian, N.; Reilias, G.; Ponniah, S.; Papamichail, M.; Peoples, G. E.; Mittendorf, E. A.] UT MD Anderson Canc Ctr, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P1-13-01 DI 10.1158/0008-5472.SABCS11-P1-13-01 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800295 ER PT J AU Kovatich, AJ Kvecher, L Chen, Y Bekhash, A Hooke, JA Shriver, CD Mural, RJ Hu, H AF Kovatich, A. J. Kvecher, L. Chen, Y. Bekhash, A. Hooke, J. A. Shriver, C. D. Mural, R. J. Hu, H. TI Subtype-Specific Co-Occurrence of Atypical Hyperplasia and In Situ Carcinoma with Invasive Breast Cancers SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Kovatich, A. J.; Kvecher, L.; Chen, Y.; Bekhash, A.; Hooke, J. A.; Shriver, C. D.; Mural, R. J.; Hu, H.] Windber Res Inst, Windber, PA USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. MDR Global Syst LLC, Windber, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P3-05-02 DI 10.1158/0008-5472.SABCS11-P3-05-02 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699801263 ER PT J AU Peck, AR Witkiewicz, AK Liu, C Klimowicz, AC Stringer, GA Pequignot, E Freydin, B Yang, N Tran, TH Rosenberg, AL Hooke, JA Kovatich, AJ Shriver, CD Rimm, DL Magliocco, AM Hyslop, T Rui, H AF Peck, A. R. Witkiewicz, A. K. Liu, C. Klimowicz, A. C. Stringer, G. A. Pequignot, E. Freydin, B. Yang, N. Tran, T. H. Rosenberg, A. L. Hooke, J. A. Kovatich, A. J. Shriver, C. D. Rimm, D. L. Magliocco, A. M. Hyslop, T. Rui, H. TI Nuclear Localization of Stat5a Predicts Response to Antiestrogen Therapy and Prognosis of Clinical Breast Cancer Outcome. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Peck, A. R.; Witkiewicz, A. K.; Liu, C.; Klimowicz, A. C.; Stringer, G. A.; Pequignot, E.; Freydin, B.; Yang, N.; Tran, T. H.; Rosenberg, A. L.; Hooke, J. A.; Kovatich, A. J.; Shriver, C. D.; Rimm, D. L.; Magliocco, A. M.; Hyslop, T.; Rui, H.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. Tom Baker Canc Clin, Calgary, AB, Canada. Walter Reed Army Med Ctr, Washington, DC 20307 USA. MDR Global Syst LLC, Windber, PA USA. Yale Univ, Sch Med, New Haven, CT USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P1-06-24 DI 10.1158/0008-5472.SABCS11-P1-06-24 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800231 ER PT J AU Sears, AK Clifton, GT Vreeland, TJ Hale, DF Ponniah, S Mittendorf, EA Peoples, GE AF Sears, A. K. Clifton, G. T. Vreeland, T. J. Hale, D. F. Ponniah, S. Mittendorf, E. A. Peoples, G. E. TI Combination Immunotherapy with Trastuzumab and the HER2 Vaccine E75 in Low and Intermediate HER2-Expressing Breast Cancer Patients To Prevent Recurrence. SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Sears, A. K.; Clifton, G. T.; Vreeland, T. J.; Hale, D. F.; Ponniah, S.; Mittendorf, E. A.; Peoples, G. E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Uniformed Serv Univ Hlth Sci, USMCI, Bethesda, MD 20814 USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA OT3-01-18 DI 10.1158/0008-5472.SABCS11-OT3-01-18 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800045 ER PT J AU Vreeland, TJ Clifton, GT Sears, AK Hale, DF Patil, R Clive, KS Holmes, JP Mittendorf, EA Ponniah, S Peoples, GE AF Vreeland, T. J. Clifton, G. T. Sears, A. K. Hale, D. F. Patil, R. Clive, K. S. Holmes, J. P. Mittendorf, E. A. Ponniah, S. Peoples, G. E. TI Long-Term Clinical Benefit of Adjuvant Breast Cancer Vaccine: 5 Year Efficacy of E75 with Multiple Booster Inoculations SO CANCER RESEARCH LA English DT Meeting Abstract C1 [Vreeland, T. J.; Clifton, G. T.; Sears, A. K.; Hale, D. F.; Patil, R.; Clive, K. S.; Holmes, J. P.; Mittendorf, E. A.; Ponniah, S.; Peoples, G. E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Vreeland, T. J.; Clifton, G. T.; Sears, A. K.; Hale, D. F.; Patil, R.; Clive, K. S.; Holmes, J. P.; Mittendorf, E. A.; Ponniah, S.; Peoples, G. E.] Windber Med Ctr, Windber, PA USA. [Vreeland, T. J.; Clifton, G. T.; Sears, A. K.; Hale, D. F.; Patil, R.; Clive, K. S.; Holmes, J. P.; Mittendorf, E. A.; Ponniah, S.; Peoples, G. E.] Naval Med Ctr San Diego, San Diego, CA USA. [Vreeland, T. J.; Clifton, G. T.; Sears, A. K.; Hale, D. F.; Patil, R.; Clive, K. S.; Holmes, J. P.; Mittendorf, E. A.; Ponniah, S.; Peoples, G. E.] UT MD Anderson Canc Ctr, Houston, TX USA. [Vreeland, T. J.; Clifton, G. T.; Sears, A. K.; Hale, D. F.; Patil, R.; Clive, K. S.; Holmes, J. P.; Mittendorf, E. A.; Ponniah, S.; Peoples, G. E.] Uniformed Serv Univ Hlth Sci, USMCI, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 EI 1538-7445 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 2011 VL 71 SU 24 MA P1-13-02 DI 10.1158/0008-5472.SABCS11-P1-13-02 PG 1 WC Oncology SC Oncology GA V43RZ UT WOS:000209699800296 ER PT J AU Saxena, A Sun, W Dabisch, PA Hulet, SW Hastings, NB Jakubowski, EM Mioduszewski, RJ Doctor, BP AF Saxena, Ashima Sun, Wei Dabisch, Paul A. Hulet, Stanley W. Hastings, Nicholas B. Jakubowski, Edward M. Mioduszewski, Robert J. Doctor, Bhupendra P. TI Pretreatment with human serum butyrylcholinesterase alone prevents cardiac abnormalities, seizures, and death in Gottingen minipigs exposed to sarin vapor SO BIOCHEMICAL PHARMACOLOGY LA English DT Article DE Human serum butyrylcholinesterase; Minipig; Sarin vapor; Cardiac abnormality; Neuronal toxicity ID NERVE AGENT TOXICITY; GUINEA-PIGS; ACETYLCHOLINESTERASE ACTIVITY; CLINICAL-MANIFESTATIONS; PERCUTANEOUS EXPOSURE; CYNOMOLGUS MONKEYS; SOMAN; RATS; VX; PROPHYLAXIS AB Human serum butyrylcholinesterase (Hu BChE) is a stoichiometric bioscavenger that is being developed as a prophylactic countermeasure against organophosphorus nerve agents. This study was designed to evaluate the efficacy of Hu BChE against whole-body inhalation exposure to a lethal dose of sarin (GB) vapor. Male Gottingen minipigs were subjected to: air exposure. GB vapor exposure, or pretreatment with Hu BChE followed by GB vapor exposure. Hu BChE was administered by i.m. injection 24 h prior to exposure to 4.1 mg/m(3) of GB vapor for 60 min. Electrocardiograms (ECG), electroencephalograms (EEG), and pupil size were recorded throughout exposure. Blood drawn before and throughout exposure was analyzed for blood gases, electrolytes, metabolites, acetylcholinesterase and BChE activities, and amount of GB present. Untreated animals exposed to GB vapor exhibited cardiac abnormalities and generalized seizures, ultimately succumbing to respiratory failure. Pretreatment with 3.0 or 6.5 mg/kg of Hu BChE delayed blood gas and acid-base disturbances and the onset of cardiac and neural toxic signs, but failed to increase survivability. Pretreatment with 7.5 mg/kg of Hu BChE, however, completely prevented toxic signs, with blood chemistry and ECG and EEG parameters indistinguishable from control during and after GB exposure. GB bound in plasma was 200-fold higher than plasma from pigs that did not receive Hu BChE, suggesting that Hu BChE scavenged GB in blood and prevented it from reaching other tissues. Thus, prophylaxis with Hu BChE alone not only increased survivability, but also prevented cardiac abnormalities and neural toxicity in minipigs exposed to a lethal dose of GB vapor. Published by Elsevier Inc. C1 [Saxena, Ashima; Sun, Wei; Hastings, Nicholas B.; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Dabisch, Paul A.; Hulet, Stanley W.; Jakubowski, Edward M.; Mioduszewski, Robert J.] Edgewood Chem Biol Ctr, Div Operat Toxicol Team, Aberdeen Proving Ground, MD 21010 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Ashima.saxena@us.army.mil FU Defense Threat Reduction Agency FX The authors wish to thank Ms. Amy Michels for her assistance in preparation of the manuscript. This research was supported by funding from the Defense Threat Reduction Agency. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Army or the Department of Defense. NR 48 TC 22 Z9 23 U1 0 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD DEC 15 PY 2011 VL 82 IS 12 BP 1984 EP 1993 DI 10.1016/j.bcp.2011.09.019 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 849RE UT WOS:000297142000019 PM 21968035 ER PT J AU Domine, F Gallet, JC Barret, M Houdier, S Voisin, D Douglas, TA Blum, JD Beine, HJ Anastasio, C Breon, FM AF Domine, Florent Gallet, Jean-Charles Barret, Manuel Houdier, Stephan Voisin, Didier Douglas, Thomas A. Blum, Joel D. Beine, Harry J. Anastasio, Cort Breon, Francois-Marie TI The specific surface area and chemical composition of diamond dust near Barrow, Alaska SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID ENVIRONMENTAL WATER SAMPLES; BIOLOGICAL ICE NUCLEATORS; ALERT 2000 CAMPAIGN; ARCTIC SEA-ICE; ANTARCTIC PLATEAU; AQUEOUS PHOTOOXIDATION; RADIATIVE-TRANSFER; AEROSOL PRODUCTION; OPTICAL-PROPERTIES; CRYSTAL-FORMATION AB Diamond dust (DD) refers to tiny ice crystals that form frequently in the Polar troposphere under clear sky conditions. They provide surfaces for chemical reactions and scatter light. We have measured the specific surface area (SSA) of DD at Barrow in March-April 2009. We have also measured its chemical composition in mineral and organic ions, dissolved organic carbon (DOC), aldehydes, H2O2, and the absorption spectra of water-soluble chromophores. Mercury concentrations were also measured in spring 2006, when conditions were similar. The SSA of DD ranges from 79.9 to 223 m(2) kg(-1). The calculated ice surface area in the atmosphere reaches 11000 (+/- 70%) mu m(2) cm(-3), much higher than the aerosol surface area. However, the impact of DD on the downwelling and upwelling light fluxes in the UV and visible is negligible. The composition of DD is markedly different from that of snow on the surface. Its concentrations in mineral ions are much lower, and its overall composition is acidic. Its concentrations in aldehydes, DOC, H2O2 and mercury are much higher than in surface snows. Our interpretation is that DOC from the oceanic surface microlayer, coming from open leads in the ice off of Barrow, is taken up by DD. Active chemistry in the atmosphere takes place on DD crystal surfaces, explaining its high concentrations in aldehydes and mercury. After deposition, active photochemistry modifies DD composition, as seen from the modifications in its absorption spectra and aldehyde and H2O2 content. This probably leads to the emissions of reactive species to the atmosphere. C1 [Domine, Florent; Gallet, Jean-Charles; Barret, Manuel; Houdier, Stephan; Voisin, Didier] CNRS INSU, Lab Glaciol & Geophys Environm, F-38402 St Martin Dheres, France. [Domine, Florent; Gallet, Jean-Charles; Barret, Manuel; Houdier, Stephan; Voisin, Didier] Univ Grenoble 1, Observ Sci Univ Grenoble, Grenoble, France. [Domine, Florent] Univ Laval, Takuvik Joint Int Lab, Quebec City, PQ G1V 0A6, Canada. [Domine, Florent] CNRS, F-75700 Paris, France. [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Blum, Joel D.] Univ Michigan, Dept Earth & Environm Sci, Ann Arbor, MI 48109 USA. [Beine, Harry J.; Anastasio, Cort] Univ Calif Davis, Dept Land Air & Water Resources, Davis, CA 95616 USA. [Breon, Francois-Marie] UMR CEA CNRS UVSQ, Lab Sci Climat & Environm, F-91191 Gif Sur Yvette, France. RP Domine, F (reprint author), CNRS INSU, Lab Glaciol & Geophys Environm, BP 96, F-38402 St Martin Dheres, France. EM florent.domine@gmail.com RI voisin, didier/F-9911-2010; Breon, Francois-Marie/M-4639-2016 OI voisin, didier/0000-0003-1317-7561; Breon, Francois-Marie/0000-0003-2128-739X FU French Polar Institute (IPEV) [1017]; U.S. National Science Foundation [NSF ATM-0807702] FX This work is part of the international multi-disciplinary OASIS (Ocean-atmosphere-Sea Ice-Snowpack) program. It was supported by the French Polar Institute (IPEV) through grant 1017 to F. D., and by the U.S. National Science Foundation through grant NSF ATM-0807702. T. A. D. also acknowledges partial support from the U.S. National Science Foundation. The Barrow Arctic Science Consortium is acknowledged for providing logistical support in the Barrow area. We thank Lee Mauldin for calculating the back trajectories. Kelsey Johnson helped with the additional mercury concentration data from the samples collected in 2006. Ghislain Picard kindly calculated the downwelling fluxes with the SBDART model. NR 73 TC 16 Z9 16 U1 2 U2 22 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD DEC 14 PY 2011 VL 116 AR D00R06 DI 10.1029/2011JD016162 PG 18 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 864QC UT WOS:000298253800002 ER PT J AU Knapik, JJ Grier, T Spiess, A Swedler, DI Hauret, KG Graham, B Yoder, J Jones, BH AF Knapik, Joseph J. Grier, Tyson Spiess, Anita Swedler, David I. Hauret, Keith G. Graham, Bria Yoder, James Jones, Bruce H. TI Injury rates and injury risk factors among Federal Bureau of Investigation new agent trainees SO BMC PUBLIC HEALTH LA English DT Article DE Physical training; Age; Body mass index; Physical activity; Physical fitness ID PHYSICAL-TRAINING PROGRAM; EXERCISE-RELATED INJURIES; SMOKELESS TOBACCO USE; LIFE-STYLE FACTORS; MUSCULOSKELETAL INJURIES; STRESS-FRACTURES; SPORTS INJURIES; CIGARETTE-SMOKING; HIGH-SCHOOL; YOUNG MEN AB Background: A one-year prospective examination of injury rates and injury risk factors was conducted in Federal Bureau of Investigation (FBI) new agent training. Methods: Injury incidents were obtained from medical records and injury compensation forms. Potential injury risk factors were acquired from a lifestyle questionnaire and existing data at the FBI Academy. Results: A total of 426 men and 105 women participated in the project. Thirty-five percent of men and 42% of women experienced one or more injuries during training. The injury incidence rate was 2.5 and 3.2 injuries/1,000 person-days for men and women, respectively (risk ratio (women/men) = 1.3, 95% confidence interval = 0.9-1.7). The activities most commonly associated with injuries (% of total) were defensive tactics training (58%), physical fitness training (20%), physical fitness testing (5%), and firearms training (3%). Among the men, higher injury risk was associated with older age, slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the physical fitness test (PFT), lower self-rated physical activity, lower frequency of aerobic exercise, a prior upper or lower limb injury, and prior foot or knee pain that limited activity. Among the women higher injury risk was associated with slower 300-meter sprint time, slower 1.5-mile run time, lower total points on the PFT, and prior back pain that limited activity. Conclusion: The results of this investigation supported those of a previous retrospective investigation emphasizing that lower fitness and self-reported pain limiting activity were associated with higher injury risk among FBI new agents. C1 [Knapik, Joseph J.; Grier, Tyson; Spiess, Anita; Hauret, Keith G.; Graham, Bria; Jones, Bruce H.] USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. [Swedler, David I.] Johns Hopkins Univ, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA. [Yoder, James] Fed Bur Invest, Human Resources Div, Off Med Serv, Hlth Care Programs Unit, Washington, DC USA. RP Knapik, JJ (reprint author), USA, Inst Publ Hlth, Aberdeen Proving Ground, MD USA. EM joseph.knapik@us.army.mil FU FBI; US Army Public Health Command FX For their outstanding assistance with this investigation we would like to thank Ms Tanya Harvin, Special Agent Timothy Burke, Special Agent Gerald Jackson, Special Agent Susann Dreiling, Special Agent Jay Moeller, Special Agent Michael Vuogh, Dr. Tom Gross, Ms Terry Dotson, Ms Tammy Schuldt, Special Agent Melinda Casey, Dr David Wade, Ms Margaret Gray and Dr William Fabbri. This study was funded internally by the FBI and the US Army Public Health Command. NR 103 TC 11 Z9 11 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2458 J9 BMC PUBLIC HEALTH JI BMC Public Health PD DEC 13 PY 2011 VL 11 AR 920 DI 10.1186/1471-2458-11-920 PG 16 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 908NJ UT WOS:000301496800001 PM 22166096 ER PT J AU Newton, PN Green, MD Mildenhall, DC Plancon, A Nettey, H Nyadong, L Hostetler, DM Swamidoss, I Harris, GA Powell, K Timmermans, AE Amin, AA Opuni, SK Barbereau, S Faurant, C Soong, RCW Faure, K Thevanayagam, J Fernandes, P Kaur, H Angus, B Stepniewska, K Guerin, PJ Fernandez, FM AF Newton, Paul N. Green, Michael D. Mildenhall, Dallas C. Plancon, Aline Nettey, Henry Nyadong, Leonard Hostetler, Dana M. Swamidoss, Isabel Harris, Glenn A. Powell, Kristen Timmermans, Ans E. Amin, Abdinasir A. Opuni, Stephen K. Barbereau, Serge Faurant, Claude Soong, Ray C. W. Faure, Kevin Thevanayagam, Jonarthan Fernandes, Peter Kaur, Harparkash Angus, Brian Stepniewska, Kasia Guerin, Philippe J. Fernandez, Facundo M. TI Poor quality vital anti-malarials in Africa - an urgent neglected public health priority SO MALARIA JOURNAL LA English DT Article ID ANTIMALARIAL-DRUG QUALITY; FALCIPARUM-MALARIA; MASS-SPECTROMETRY; ARTEMISININ; RESISTANCE AB Background: Plasmodium falciparum malaria remains a major public health problem. A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa. Methods: Seven collections of artemisinin derivative monotherapies, ACT and halofantrine anti-malarials of suspicious quality were collected in 2002/10 in eleven African countries and in Asia en route to Africa. Packaging, chemical composition (high performance liquid chromatography, direct ionization mass spectrometry, X-ray diffractometry, stable isotope analysis) and botanical investigations were performed. Results: Counterfeit artesunate containing chloroquine, counterfeit dihydroartemisinin (DHA) containing paracetamol (acetaminophen), counterfeit DHA-piperaquine containing sildenafil, counterfeit artemether-lumefantrine containing pyrimethamine, counterfeit halofantrine containing artemisinin, and substandard/counterfeit or degraded artesunate and artesunate+amodiaquine in eight countries are described. Pollen analysis was consistent with manufacture of counterfeits in eastern Asia. These data do not allow estimation of the frequency of poor quality anti-malarials in Africa. Conclusions: Criminals are producing diverse harmful anti-malarial counterfeits with important public health consequences. The presence of artesunate monotherapy, substandard and/or degraded and counterfeit medicines containing sub-therapeutic amounts of unexpected anti-malarials will engender drug resistance. With the threatening spread of artemisinin resistance to Africa, much greater investment is required to ensure the quality of ACTs and removal of artemisinin monotherapies. The International Health Regulations may need to be invoked to counter these serious public health problems. C1 [Newton, Paul N.] Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Univ Trop Med, Viangchan, Laos. [Newton, Paul N.; Thevanayagam, Jonarthan; Fernandes, Peter; Angus, Brian; Stepniewska, Kasia; Guerin, Philippe J.] Univ Oxford, Churchill Hosp, Nuffield Dept Med, Ctr Trop Med, Oxford OX3 7LJ, England. [Newton, Paul N.; Kaur, Harparkash] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England. [Newton, Paul N.; Guerin, Philippe J.] Univ Oxford, Churchill Hosp, WorldWide Antimalarial Resistance Network, Oxford OX3 7LJ, England. [Green, Michael D.; Nettey, Henry; Swamidoss, Isabel] Ctr Dis Control & Prevent, Div Parasit Dis & Malaria, Ctr Global Hlth, Atlanta, GA 30329 USA. [Mildenhall, Dallas C.; Soong, Ray C. W.; Faure, Kevin] GNS Sci, Lower Hutt 5040, New Zealand. [Plancon, Aline] Int Criminal Police Org INTERPOL, F-69006 Lyon, France. [Nyadong, Leonard; Hostetler, Dana M.; Harris, Glenn A.; Powell, Kristen; Fernandez, Facundo M.] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA. [Timmermans, Ans E.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Amin, Abdinasir A.] Populat Serv Int, Malaria & Child Survival Dept, Nairobi, Kenya. [Opuni, Stephen K.] Food & Drugs Board, Cantonments Accra, Ghana. [Barbereau, Serge] Reseau Medicaments & Dev ReMeD, F-75013 Paris 13, France. [Faurant, Claude] E W Pharmaceut, F-77300 Fontainebleau, France. [Stepniewska, Kasia] Mahidol Univ, Fac Trop Med, Mahidol Oxford Res Unit, Bangkok 10400, Thailand. RP Newton, PN (reprint author), Mahosot Hosp, Microbiol Lab, Wellcome Trust Mahosot Hosp Oxford Univ Trop Med, Viangchan, Laos. EM paul@tropmedres.ac RI Fernandez, Facundo/B-7015-2008; OI Angus, Brian/0000-0003-3598-7784; Guerin, Philippe/0000-0002-6008-2963 FU NSF; USP; Wellcome Trust of Great Britain; Wellcome Trust; ACT Consortium; Bill & Melinda Gates Foundation FX The method development work of FMF was funded by an NSF CAREER grant. LN was partially supported by a USP graduate fellowship. PNN is supported by the Wellcome Trust of Great Britain. Forensic analysis was conducted through the support of the Wellcome Trust and the ACT Consortium, funded by the Bill & Melinda Gates Foundation to the London School of Hygiene and Tropical Medicine. The funding bodies had no role in the design and conduct of the study and had no role in the decision to publish. NR 46 TC 45 Z9 46 U1 0 U2 29 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD DEC 13 PY 2011 VL 10 AR 352 DI 10.1186/1475-2875-10-352 PG 22 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 893JY UT WOS:000300353400001 PM 22152094 ER PT J AU Peck, AR Witkiewicz, AK Liu, CB Stringer, GA Klimowicz, AC Pequignot, EC Freydin, BC Tran, TH Yang, N Rosenberg, AL Hooke, JA Kovatich, AJ Nevalainen, MT Shriver, CD Hyslop, T Sauter, G Rimm, DL Magliocco, AM Rui, H AF Peck, Amy R. Witkiewicz, Agnieszka K. Liu, Chengbao Stringer, Ginger A. Klimowicz, Alexander C. Pequignot, Edward C. Freydin, Boris C. Tran, Thai H. Yang, Ning Rosenberg, Anne L. Hooke, Jeffrey A. Kovatich, Albert J. Nevalainen, Marja T. Shriver, Craig D. Hyslop, Terry Sauter, Guido Rimm, David L. Magliocco, Anthony M. Rui, Hallgeir TI Prognostic or Predictive? It's Time to Get Back to Definitions! Reply SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Letter ID BREAST-CANCER; STAT5; THERAPY C1 [Peck, Amy R.; Witkiewicz, Agnieszka K.; Liu, Chengbao; Stringer, Ginger A.; Pequignot, Edward C.; Freydin, Boris C.; Tran, Thai H.; Yang, Ning; Rosenberg, Anne L.; Nevalainen, Marja T.; Hyslop, Terry; Rui, Hallgeir] Thomas Jefferson Univ, Philadelphia, PA 19107 USA. [Klimowicz, Alexander C.; Magliocco, Anthony M.] Alberta Canc Board, Tom Baker Canc Ctr, Calgary, AB, Canada. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kovatich, Albert J.] MDR Global Syst, Windber, PA USA. [Sauter, Guido] Univ Med Ctr Hamburg Eppendorf, Hamburg, Germany. [Rimm, David L.] Yale Univ, Sch Med, New Haven, CT USA. RP Peck, AR (reprint author), Thomas Jefferson Univ, Philadelphia, PA 19107 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD DEC 10 PY 2011 VL 29 IS 35 BP 4718 EP 4719 DI 10.1200/JCO.2011.38.5187 PG 3 WC Oncology SC Oncology GA 863CZ UT WOS:000298141700029 ER PT J AU Gibson, S Heath, R Abraham, D Schoellhamer, D AF Gibson, S. Heath, R. Abraham, D. Schoellhamer, D. TI Visualization and analysis of temporal trends of sand infiltration into a gravel bed SO WATER RESOURCES RESEARCH LA English DT Article ID FINE; DEPOSITION; SILTATION; TRANSPORT; FRAMEWORK; SEDIMENTS AB Sand infiltration into gravel frameworks affects a wide range of ecological, geomorphic, and engineering processes. Four flume experiments were conducted with tracer materials to examine how a sand pulse infiltrates into a gravel bed. These experiments were primarily designed to test two hypotheses: (1) that vertical gradational trends of interstitial deposits are due to differential transport of finer sand in suspended load (hydraulic sorting) and (2) that the formation of a bridge layer (a thin layer of infiltrated sediments that become lodged in shallow pore throats) precludes subsequent infiltration into a gravel framework. Several sand colors were sequentially introduced into a flume containing a gravel substrate. After the experiments were conducted bed cores were collected and separated into vertical layers including surface layers composed primarily of sand that was transporting as bed load before the experiment was terminated and interstitial deposits in the gravel framework. Sand from each layer was sieved and measured. The color distribution of each grain class of each vertical layer of each core was measured to determine the temporal provenance of the interstitial deposits. Results supported the occurrence of hydraulic sorting. Older (finer) sand particles were disproportionately prevalent in interstitial deposits when compared to bed load samples. The experiments did not support the second hypothesis. Substantial secondary infiltration occurred after the initial formation of a bridge layer. More secondary infiltration was measured for systems with higher d(15Gravel)/d(85Sand) ratios and when bed shear was sufficient to mobilize the gravel. C1 [Gibson, S.] Hydrol Engn Ctr, Davis, CA 95616 USA. [Heath, R.; Abraham, D.] USACE Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Schoellhamer, D.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. RP Gibson, S (reprint author), Hydrol Engn Ctr, 609 2nd St, Davis, CA 95616 USA. EM stanford.gibson@usace.army.mil; ronald.e.heath@usace.army.mil; david.d.abraham@usace.army.mil; d.schoellhamer@comcast.net FU U.S. Army Corps of Engineers FX This work was funded by the System Wide Water Resources Program (SWWRP) of the U.S. Army Corps of Engineers. Nolan Caldwell performed the calibration of the image analysis process. Lucina Gibson counted over 250,000 of the colored sand grains. This manuscript was greatly improved by comments from John Wooster and two anonymous reviewers. NR 26 TC 6 Z9 6 U1 0 U2 16 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD DEC 7 PY 2011 VL 47 AR W12601 DI 10.1029/2011WR010486 PG 11 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 860ZN UT WOS:000297987900002 ER PT J AU Ogden, FL Pradhan, NR Downer, CW Zahner, JA AF Ogden, Fred L. Pradhan, Nawa Raj Downer, Charles W. Zahner, Jon A. TI Relative importance of impervious area, drainage density, width function, and subsurface storm drainage on flood runoff from an urbanized catchment SO WATER RESOURCES RESEARCH LA English DT Article ID HYDROLOGIC RESPONSE; FLASH-FLOOD; BASIN; MODEL; WATERSHEDS; SYSTEMS AB The literature contains contradictory conclusions regarding the relative effects of urbanization on peak flood flows due to increases in impervious area, drainage density and width function, and the addition of subsurface storm drains. We used data from an urbanized catchment, the 14.3 km(2) Dead Run watershed near Baltimore, Maryland, USA, and the physics-based gridded surface/subsurface hydrologic analysis (GSSHA) model to examine the relative effect of each of these factors on flood peaks, runoff volumes, and runoff production efficiencies. GSSHA was used because the model explicitly includes the spatial variability of land-surface and hydrodynamic parameters, including subsurface storm drains. Results indicate that increases in drainage density, particularly increases in density from low values, produce significant increases in the flood peaks. For a fixed land-use and rainfall input, the flood magnitude approaches an upper limit regardless of the increase in the channel drainage density. Changes in imperviousness can have a significant effect on flood peaks for both moderately extreme and extreme storms. For an extreme rainfall event with a recurrence interval in excess of 100 years, imperviousness is relatively unimportant in terms of runoff efficiency and volume, but can affect the peak flow depending on rainfall rate. Changes to the width function affect flood peaks much more than runoff efficiency, primarily in the case of lower density drainage networks with less impermeable area. Storm drains increase flood peaks, but are overwhelmed during extreme rainfall events when they have a negligible effect. Runoff in urbanized watersheds with considerable impervious area shows a marked sensitivity to rainfall rate. This sensitivity explains some of the contradictory findings in the literature. C1 [Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA. [Pradhan, Nawa Raj; Downer, Charles W.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Zahner, Jon A.] Univ Connecticut, Sch Dent Med, Farmington, CT 06032 USA. RP Ogden, FL (reprint author), Univ Wyoming, Dept Civil & Architectural Engn, 1000 E Univ Ave, Laramie, WY 82071 USA. EM fogden@uwyo.edu FU U.S. Army Research Office [DAAD19-03-1-0355, DAAD19-01-1-0629, DAAG55-98-1-0069 (DURIP)]; U.S. National Science Foundation [EAR-0003408]; U.S. Army Corps of Engineers, Engineer Research and Development Center FX This study was initiated in the M.S. Thesis work of Jon Zahner [Zahner 2004]. Since that time significant improvements were made to the GSSHA and SUPERLINK code and an entire reanalysis was performed. Radar-rainfall and rain gauge data were for the Dead Run catchment were provided by James A. Smith of Princeton University. Data for the Dead Run storm drainage network were provided by Katherine Meierdierks while a student at Princeton. Streamflow data were provided by the USGS. This study was funded in part by U.S. Army Research Office through grants DAAD19-03-1-0355, DAAD19-01-1-0629, DAAG55-98-1-0069 (DURIP) and the U.S. National Science Foundation through grant EAR-0003408 while the lead author was at the University of CT. GSSHA development is funded by the U.S. Army Corps of Engineers, Engineer Research and Development Center. We acknowledge constructive review comments by Daniel Wright, Ph.D. student at Princeton University, two anonymous reviewers, and Associate Editor Graham Sander. NR 46 TC 26 Z9 26 U1 0 U2 55 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD DEC 3 PY 2011 VL 47 AR W12503 DI 10.1029/2011WR010550 PG 12 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 856OF UT WOS:000297651500001 ER PT J AU Wang, Z Yang, Y Yang, H Capo-Aponte, JE Tachado, SD Wolosin, JM Reinach, PS AF Wang, Z. Yang, Y. Yang, H. Capo-Aponte, J. E. Tachado, S. D. Wolosin, J. M. Reinach, P. S. TI NF-kappa B feedback control of JNK1 activation modulates TRPV1-induced increases in IL-6 and IL-8 release by human corneal epithelial cells SO MOLECULAR VISION LA English DT Article ID INFLAMMATORY CYTOKINE RELEASE; RECEPTOR; PHOSPHATASE-1; CROSSTALK; DELTA; MICE AB Purpose: The corneal wound healing response to an alkali burn results in dysregulated inflammation and opacity. Transient receptor potential vanilloid type1 (TRPV1) ion channel activation by such a stress contributes to this unfavorable outcome. Accordingly, we sought to identify potential drug targets for mitigating this response, in human corneal epithelial cells (HCEC). Methods: SV40-immmortalized HCEC were transduced with lentiviral vectors to establish stable c-Jun N-terminal kinase1 (JNK1), nuclear factor-kappa B1 (NF-kappa B1), and dual specificity phsophatase1 (DUSP1) shRNAmir sublines. Immunoblotting evaluated the expression of NF-kappa B1, DUSP1, protein kinase C delta (PKC delta), and the phosphorylation status of cell signaling mediators. Enzyme-linked immunosorbent assay (ELISA) evaluated interleukin-6 (IL-6) and interleukin-8 (IL-8) release. Results: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (I kappa B alpha) phosphorylation, rises in both PKC delta protein levels and IL-6 and IL-8 release. All of these responses were blocked by the TAK1 inhibitor 5z-7-oxozeaenol (5z-OX). In the JNK1 subline, CAP failed to increase IL-6/8 release, but still stimulated NF-kappa B by 50%. In the NF-kappa B1 subline, these IL-6/8 responses were absent, JNK1 activation was attenuated and there was a concomitant increase in DUSP1 expression compared to the control. In the DUSP1 subline, JNK1 phosphorylation was enhanced and prolonged and accompanied by larger increases in IL-6/8 release. Conclusions: TRPV1 induced increases in IL-6/IL-8 release occur through TAK1 activation of JNK1-dependent and JNK1-independent signaling pathways. Their joint activation is required for NF-kappa B to elicit sufficient positive feedback control of JNK1/2 phosphorylation to elicit increases in IL-6/8 release. Such regulation depends on NF-kappa B modulation of DUSP1 expression levels and associated changes in PKC delta protein levels. C1 [Wang, Z.; Yang, Y.; Yang, H.; Capo-Aponte, J. E.; Reinach, P. S.] SUNY, State Coll Optometry, Dept Biol Sci, New York, NY 10036 USA. [Capo-Aponte, J. E.] USA, Aeromed Res Lab, Visual Sci Branch, Ft Rucker, AL USA. [Wolosin, J. M.] Mt Sinai Sch Med, Dept Ophthalmol, New York, NY USA. [Wolosin, J. M.] Mt Sinai Sch Med, Black Family Stem Cell Inst, New York, NY USA. [Tachado, S. D.] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA. [Tachado, S. D.] Harvard Univ, Sch Med, Boston, MA USA. RP Reinach, PS (reprint author), SUNY, State Coll Optometry, Dept Biol Sci, New York, NY 10036 USA. EM preinach@sunyopt.edu FU NEI [EY04795]; Department of Defense [W81XWH-09-2-0162]; Intramural Research Program [EY 014878]; NYStem [NG 326]; Research to Prevent Blindness, Inc. FX This work was supported by grants from NEI EY04795 (P.S.R.), Department of Defense (W81XWH-09-2-0162) FY08 War Supplemental Intramural Research Program (J.E.C.), Intramural Research Program EY 014878 (J.M.W.), NYStem NG 326 (J.M.W.), and Research to Prevent Blindness, Inc. (J.M.W.). The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision, unless so designated by other official documentation. Citation of trade names in this report does not constitute an official Department of the Army endorsement or approval of the use of such commercial items. NR 20 TC 15 Z9 17 U1 1 U2 1 PU MOLECULAR VISION PI ATLANTA PA C/O JEFF BOATRIGHT, LAB B, 5500 EMORY EYE CENTER, 1327 CLIFTON RD, N E, ATLANTA, GA 30322 USA SN 1090-0535 J9 MOL VIS JI Mol. Vis. PD DEC 2 PY 2011 VL 17 IS 338 BP 3137 EP 3146 PG 10 WC Biochemistry & Molecular Biology; Ophthalmology SC Biochemistry & Molecular Biology; Ophthalmology GA 871KE UT WOS:000298736100001 PM 22171160 ER PT J AU Males, RM Melby, JA AF Males, Richard M. Melby, Jeffrey A. TI Monte Carlo simulation model for economic evaluation of rubble mound breakwater protection in Harbors SO FRONTIERS OF EARTH SCIENCE LA English DT Article DE coastal protection; Monte Carlo simulation (MCS); life-cycle modeling; risk analysis; rubble mound breakwaters; planning ID WAVE RUNUP AB The US Army Corps of Engineers has a mission to conduct a wide array of programs in the arenas of water resources, including coastal protection. Coastal projects must be evaluated according to sound economic principles, and considerations of risk assessment and sea level change must be included in the analysis. Breakwaters are typically nearshore structures designed to reduce wave action in the lee of the structure, resulting in calmer waters within the protected area, with attendant benefits in terms of usability by navigation interests, shoreline protection, reduction of wave runup and onshore flooding, and protection of navigation channels from sedimentation and wave action. A common method of breakwater construction is the rubble mound breakwater, constructed in a trapezoidal cross section with gradually increasing stone sizes from the core out. Rubble mound breakwaters are subject to degradation from storms, particularly for antiquated designs with under-sized stones insufficient to protect against intense wave energy. Storm waves dislodge the stones, resulting in lowering of crest height and associated protective capability for wave reduction. This behavior happens over a long period of time, so a lifecycle model (that can analyze the damage progression over a period of years) is appropriate. Because storms are highly variable, a model that can support risk analysis is also needed. Economic impacts are determined by the nature of the wave climate in the protected area, and by the nature of the protected assets. Monte Carlo simulation (MCS) modeling that incorporates engineering and economic impacts is a worthwhile method for handling the many complexities involved in real world problems. The Corps has developed and utilized a number of MCS models to compare project alternatives in terms of their costs and benefits. This paper describes one such model, Coastal Structure simulation (CSsim) that has been developed specifically for planning level analysis of breakwaters. C1 [Males, Richard M.] RMM Tech Serv, Cincinnati, OH 45208 USA. [Melby, Jeffrey A.] USA, Engineer R&D Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Males, RM (reprint author), RMM Tech Serv, 3319 Eastside Ave, Cincinnati, OH 45208 USA. EM males@iac.net FU US Army Corps of Engineers, Navigation Systems Research and Development Program FX The development of this model was supported by research funding of the US Army Corps of Engineers, Navigation Systems Research and Development Program. The original impetus for developing a risk-based model came from Dr. David Moser, Chief Economist, Corps of Engineers. Mr. Keith Hofseth of the Institute for Water Resources of the Corps of Engineers provided guidance on economic impacts, as did Mr. Brian Harper of the Corps. Dr. Norberto Nadal of the Engineer Research and Development Center (ERDC), Coastal and Hydraulics Laboratory, developed the diffraction lookup tables and implemented methodologies for storm identification and simulation. The Point Judith study is being conducted by the New England District of the Corps of Engineers, Michael Walsh, Project Manager, John Winkelman, Coastal Engineer, and Denise Kammerer-Cody, Economist. Additional model software development effort will be carried out under the direction of Mr. Cory Rogers, CDM, Cambridge, MA. NR 10 TC 2 Z9 2 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 2095-0195 J9 FRONT EARTH SCI-PRC JI Front. Earth Sci. PD DEC PY 2011 VL 5 IS 4 BP 432 EP 441 DI 10.1007/s11707-011-0200-3 PG 10 WC Geosciences, Multidisciplinary SC Geology GA 002SX UT WOS:000308556600014 ER PT J AU Iranpour, M Turell, MJ Lindsay, LR AF Iranpour, M. Turell, M. J. Lindsay, L. R. TI POTENTIAL FOR CANADIAN MOSQUITOES TO TRANSMIT RIFT VALLEY FEVER VIRUS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Canada; vector; transmission; North America ID VECTOR COMPETENCE; SAUDI-ARABIA; CULEX-ZOMBAENSIS; SOUTH-AFRICA; EPIDEMIC; OUTBREAK; EGYPT; DISSEMINATION; CULICIDAE; TARSALIS AB The rapid spread of West Nile viral activity across North America since its discovery in 1999 illustrates the potential for an exotic arbovirus to be introduced and become widely established across North America. Rift Valley fever virus (RVFV) has been responsible for large outbreaks in Africa that have resulted in hundreds of thousands of human infections and major economic disruption due to loss of livestock and to trade restrictions. However, little is known about the potential for mosquitoes in Canada to transmit this virus, should it be introduced into North America. Therefore, we evaluated mosquito species captured near Winnipeg, Manitoba, Canada, for their ability to serve as potential vectors for RVFV. Mosquitoes were exposed to RVFV by allowing them to feed on adult hamsters inoculated the previous day with RVFV. These mosquitoes were tested for infection, dissemination, and the ability to transmit RVFV after incubation at 25 degrees C for 14-18 days. Based on the detection of virus in saliva collected in capillary tubes, individual Culex tarsalis, Aedes sticticus, and Coquillettidia perturbans were able to transmit RVFV under laboratory conditions. These preliminary results suggest that these 3 species may be able to transmit RVFV, should this virus be introduced into Canada. C1 [Turell, M. J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Iranpour, M.; Lindsay, L. R.] Univ Manitoba, Dept Entomol, Winnipeg, MB R3T 2N2, Canada. [Iranpour, M.; Lindsay, L. R.] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada. RP Turell, MJ (reprint author), USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. FU Chemical, Biological, Radiological-Nuclear Research and Technology Initiative (CRTI); Public Health Agency of Canada FX We thank John Shepard, Center for Vector Biology and Zoonotic Diseases, the Connecticut Agricultural Experiment Station, for providing the Cx. pipiens colony; Jeff Thomson and Antonia Dibernardo, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, for their advice and technical support throughout this study; and Katheryn Kenyon, USAMRIID, for her editorial comments. This project was funded by the Chemical, Biological, Radiological-Nuclear Research and Technology Initiative (CRTI) and Public Health Agency of Canada. NR 41 TC 20 Z9 21 U1 0 U2 6 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2011 VL 27 IS 4 BP 363 EP 369 PG 7 WC Entomology SC Entomology GA 973FM UT WOS:000306344600003 PM 22329267 ER PT J AU Wanja, E Parker, Z Rowland, T Turell, MJ Clark, JW Dave, K Dave, S Sang, R AF Wanja, Elizabeth Parker, Zahra Rowland, Tobin Turell, Michael J. Clark, Jeffrey W. Dave, Kirti Dave, Sonia Sang, Rosemary TI FIELD EVALUATION OF A WICKING ASSAY FOR THE RAPID DETECTION OF RIFT VALLEY FEVER VIRAL ANTIGENS IN MOSQUITOES SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Arbovirus; rapid detection; dipstick; surveillance ID SAUDI-ARABIA; EPIDEMIC; VIRUS; EGYPT; CULICIDAE; DIPTERA; KENYA AB Rift Valley fever virus (RVFV) causes outbreaks of severe disease in domestic ungulates as well as humans in Africa. There is a concern that outbreaks of Rift Valley fever may continue and that this virus may spread into regions where it had not previously been detected. Surveillance and rapid detection are critical to the initiation of an effective disease control program. Here we report on the field evaluation in Kenya of the VectorTest(R) RVFV antigen assay, modeled on the VecTest(R) assay for West Nile virus. The dipsticks provided results in <20 min, were easy to use, and did not require a laboratory with containment facilities. Although none of the field-collected mosquitoes were infected with RVFV, the dipstick provided a clear positive result with pools of field-collected mosquitoes spiked with a single positive, irradiated (to inactivate any infectious virus) mosquito. Similarly, the dipstick was able to detect virus from pools of mosquitoes captured during the RVFV outbreak in 2007. The RVFV dipstick assay was highly specific with only a single weak false positive out of 266 pools tested (specificity >99.6%). The RVFV assay can provide a rapid, safe, easy-to-use preliminary test to alert public health personnel to the presence of RVFV in mosquitoes in a given area. Results from this assay will allow for more rapid medical threat assessments and the focusing of vector control measures on high-risk areas. C1 [Turell, Michael J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Wanja, Elizabeth; Parker, Zahra; Rowland, Tobin] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Clark, Jeffrey W.] US Army Med Res Unit Kenya, Kisumu, Kenya. [Dave, Kirti; Dave, Sonia] VecTOR Test Syst Inc, Thousand Oaks, CA 91320 USA. [Sang, Rosemary] Kenya Govt Med Res Ctr, Nairobi, Kenya. RP Turell, MJ (reprint author), USA, Div Virol, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. FU DoD SBIR [W81XWH-04-C-0045, W81XWH-10-C-0041] FX We thank Joe Williamson, Santos Yawala, David Oullo, Samuel Macharia, and Vitalice Omondi, US Army Medical Research Unit-Kenya, for their assistance in collecting the mosquitoes; Joel Lutomiah, Kenyan Medical Research Institute, for rearing negative control mosquitoes; Lillian Musila and Scott Gordon for their support of the project; Josephine Esteban, US Army Medical Research Institute of Infectious Diseases (USAMRIID), for irradiating the RVFV-infected mosquitoes; and Katheryn Kenyon, USAMRIID, for her editorial suggestions. This project was funded in part by DoD SBIR contract W81XWH-04-C-0045 and W81XWH-10-C-0041 to VecTOR Test Systems, Inc. NR 21 TC 1 Z9 1 U1 0 U2 6 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 2011 VL 27 IS 4 BP 370 EP 375 PG 6 WC Entomology SC Entomology GA 973FM UT WOS:000306344600004 PM 22329268 ER PT J AU Walker, MEA AF Walker, Major Elizabeth A. TI SHAKEN BABY SYNDROME: DAUBERT AND MRE 702'S FAILURE TO EXCLUDE UNRELIABLE SCIENTIFIC EVIDENCE AND THE NEED FOR REFORM SO MILITARY LAW REVIEW LA English DT Article ID PERMANENT BRAIN-DAMAGE; SHORT-DISTANCE FALLS; HEAD-INJURY; CHILD-ABUSE; SUBDURAL HEMATOMAS; RETINAL HEMORRHAGE; MENTAL-RETARDATION; INFANT SYNDROME; SPINAL-CORD; SHAKING C1 [Walker, Major Elizabeth A.] USA, Army Litigat Div, Legal Serv Agcy, Arlington, VA USA. [Walker, Major Elizabeth A.] USA, Govt Appellate Div, Legal Serv Agcy, Arlington, VA USA. RP Walker, MEA (reprint author), USA, Army Litigat Div, Legal Serv Agcy, Arlington, VA USA. NR 96 TC 0 Z9 0 U1 1 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2011 VL 210 BP 1 EP 50 PG 50 WC Law SC Government & Law GA 964WN UT WOS:000305727500001 ER PT J AU Chelluri, MN AF Chelluri, Major Nagesh TI A NEW WAR ON AMERICA'S OLD FRONTIER: MEXICO'S DRUG CARTEL INSURGENCY SO MILITARY LAW REVIEW LA English DT Article C1 [Chelluri, Major Nagesh] USA, Washington, DC USA. RP Chelluri, MN (reprint author), Kabul Mil Training Ctr, Kabul, Afghanistan. NR 102 TC 1 Z9 1 U1 0 U2 6 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2011 VL 210 BP 51 EP 102 PG 52 WC Law SC Government & Law GA 964WN UT WOS:000305727500002 ER PT J AU Compton, CA AF Compton, Clay A. TI THE RELUCTANT COMMUNIST: MY DESERTION, COURT-MARTIAL, AND FORTY-YEAR IMPRISONMENT IN NORTH KOREA SO MILITARY LAW REVIEW LA English DT Book Review C1 [Compton, Clay A.] USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. RP Compton, CA (reprint author), USA, Judge Advocate Gen Legal Ctr & Sch, Charlottesville, VA USA. NR 22 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 2011 VL 210 BP 122 EP 129 PG 8 WC Law SC Government & Law GA 964WN UT WOS:000305727500005 ER PT J AU Gao, XG Anderson, DR Brown, AW Lin, HL Amnuaysirikul, J Chua, AL Holmes, WW Ray, P AF Gao, Xiugong Anderson, Dana R. Brown, Ammon W. Lin, Hsiuling Amnuaysirikul, Jack Chua, Aileen L. Holmes, Wesley W. Ray, Prabhati TI Pathological Studies on the Protective Effect of a Macrolide Antibiotic, Roxithromycin, against Sulfur Mustard Inhalation Toxicity in a Rat Model SO TOXICOLOGIC PATHOLOGY LA English DT Article DE sulfur mustard; respiratory injury; pathology; macrolide antibiotic; roxithromycin; rat lung; toxicity ID PHARMACOKINETIC PROPERTIES; CHRONIC SINUSITIS; EPITHELIAL-CELLS; WARFARE AGENTS; INFLAMMATION; THERAPY; THREAT AB Macrolide antibiotics have been shown to protect airway epithelial cells and macrophages from sulfur mustard (SM)-induced cytotoxicity. In the current study, the efficacy of roxithromycin in ameliorating SM-induced respiratory injury was further evaluated in a rat model. Anesthetized rats (N = 8/group) were intratracheally exposed to SM by vapor inhalation. For the drug treatment groups, rats were orally given 10, 20, or 40 mg/kg roxithromycin one hr prior to exposure and every twenty-four hr thereafter. After one, three, or seven days of treatment, sections of the lung were examined and scored for histopathological parameters. Treatment with roxithromycin ameliorated many of the symptoms caused by SM in some animals. In particular, treatment at 40 mg/kg for three days showed significant improvements (p < .05) over the untreated group. When the evaluation was focused on trachea, treatment with roxithromycin for three days showed a trend of dose-dependent protection; moreover, the groups treated with 20 or 40 mg/kg of roxithromycin were statistically different (p < .001 and p < .05, respectively) from the untreated group. These results suggest that roxithromycin protects against some damages associated with SM injury in the lung, particularly in the upper respiratory tract. C1 [Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Anderson, Dana R.; Holmes, Wesley W.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Ray, P (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM prabhati.ray@us.army.mil FU Defense Threat Reduction Agency (DTRA) [3.F0003_05_WR_C] FX This work was supported by the Defense Threat Reduction Agency (DTRA) Project No. 3.F0003_05_WR_C. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the U.S. Army or the Department of Defense. NR 26 TC 10 Z9 11 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0192-6233 J9 TOXICOL PATHOL JI Toxicol. Pathol. PD DEC PY 2011 VL 39 IS 7 BP 1056 EP 1064 DI 10.1177/0192623311422079 PG 9 WC Pathology; Toxicology SC Pathology; Toxicology GA 961IV UT WOS:000305459000004 PM 21934141 ER PT J AU Callaghan, TV Johansson, M Brown, RD Groisman, PY Labba, N Radionov, V Bradley, RS Blangy, S Bulygina, ON Christensen, TR Colman, JE Essery, RLH Forbes, BC Forchhammer, MC Golubev, VN Honrath, RE Juday, GP Meshcherskaya, AV Phoenix, GK Pomeroy, J Rautio, A Robinson, DA Schmidt, NM Serreze, MC Shevchenko, VP Shiklomanov, AI Shmakin, AB Skold, P Sturm, M Woo, MK Wood, EF AF Callaghan, Terry V. Johansson, Margareta Brown, Ross D. Groisman, Pavel Ya Labba, Niklas Radionov, Vladimir Bradley, Raymond S. Blangy, Sylvie Bulygina, Olga N. Christensen, Torben R. Colman, Jonathan E. Essery, Richard L. H. Forbes, Bruce C. Forchhammer, Mads C. Golubev, Vladimir N. Honrath, Richard E. Juday, Glenn P. Meshcherskaya, Anna V. Phoenix, Gareth K. Pomeroy, John Rautio, Arja Robinson, David A. Schmidt, Niels M. Serreze, Mark C. Shevchenko, Vladimir P. Shiklomanov, Alexander I. Shmakin, Andrey B. Skold, Peter Sturm, Matthew Woo, Ming-ko Wood, Eric F. TI Multiple Effects of Changes in Arctic Snow Cover SO AMBIO LA English DT Article DE Snow; Arctic; Climate; Albedo; Hydrology; Ecology; Biogeochemical cycling; Geochemical processes; Forestry; Infrastructure; Tourism; Indigenous cultures; Human health ID HIGH-LATITUDE ECOSYSTEMS; CLIMATE-CHANGE; NORTHERN ALASKA; HEAT-BALANCE; TUNDRA; WINTER; FOREST; REINDEER; WEATHER; REPRODUCTION AB Snow cover plays a major role in the climate, hydrological and ecological systems of the Arctic and other regions through its influence on the surface energy balance (e.g. reflectivity), water balance (e.g. water storage and release), thermal regimes (e.g. insulation), vegetation and trace gas fluxes. Feedbacks to the climate system have global consequences. The livelihoods and well-being of Arctic residents and many services for the wider population depend on snow conditions so changes have important consequences. Already, changing snow conditions, particularly reduced summer soil moisture, winter thaw events and rain-on-snow conditions have negatively affected commercial forestry, reindeer herding, some wild animal populations and vegetation. Reductions in snow cover are also adversely impacting indigenous peoples' access to traditional foods with negative impacts on human health and well-being. However, there are likely to be some benefits from a changing Arctic snow regime such as more even run-off from melting snow that favours hydropower operations. C1 [Callaghan, Terry V.] Royal Swedish Acad Sci, S-10405 Stockholm, Sweden. [Johansson, Margareta; Christensen, Torben R.] Lund Univ, Dept Earth & Ecosyst Sci, Div Phys Geog & Ecosyst Anal, S-22362 Lund, Sweden. [Brown, Ross D.] Ouranos, Montreal, PQ H3A 1B9, Canada. [Groisman, Pavel Ya] NOAA, Global Climate Applicat Div, Natl Climat Data Ctr, Asheville, NC USA. [Labba, Niklas] Gaisi Sami Ctr, N-9042 Lakselvbukt, Laksvatn, Norway. [Radionov, Vladimir] AARI, St Petersburg 199397, Russia. [Bradley, Raymond S.] Univ Massachusetts, Dept Geosci, Morrill Sci Ctr 233, Amherst, MA 01003 USA. [Blangy, Sylvie] Univ Quebec, Montreal, PQ H3C 3P8, Canada. [Bulygina, Olga N.] All Russian Res Inst Hydrometeorol Informat, World Data Ctr RIHMI WDC, Obninsk 249035, Kaluga Region, Russia. [Colman, Jonathan E.] UiO, Dept Biol, N-0316 Oslo, Norway. [Colman, Jonathan E.] UMB, Dept Ecol & Nat Resource Management, N-1432 As, Norway. [Essery, Richard L. H.] Univ Edinburgh, Sch Geosci, Edinburgh EH8 9YL, Midlothian, Scotland. [Forchhammer, Mads C.] Greenland Climate Res Ctr, Nuuk, Greenland. [Forchhammer, Mads C.] Aarhus Univ, Dept Biosci, DK-8000 Aarhus C, Denmark. [Golubev, Vladimir N.] Moscow MV Lomonosov State Univ, Lab Snow Avalanches & Mudflows, Fac Geog, Moscow 119991, Russia. [Honrath, Richard E.] Michigan Technol Univ, Dept Geol & Min Engn & Sci, Houghton, MI 49931 USA. [Honrath, Richard E.] Michigan Technol Univ, Dept Civil & Environm Engn, Houghton, MI 49931 USA. [Juday, Glenn P.] Sch Nat Resources & Agr Sci, Fairbanks, AK 99775 USA. [Phoenix, Gareth K.] Univ Sheffield, Dept Anim & Plant Sci, Western Bank, Sheffield S10 2TN, S Yorkshire, England. [Pomeroy, John] Univ Saskatchewan, Ctr Hydrol, Saskatoon, SK S7N 5C8, Canada. [Rautio, Arja] Univ Oulu, Ctr Arctic Med, Thule Inst, Oulu 90014, Finland. [Robinson, David A.] Rutgers State Univ, Dept Geog, Piscataway, NJ 08854 USA. [Schmidt, Niels M.] Aarhus Univ, Dept Biosci, DK-4000 Roskilde, Denmark. [Serreze, Mark C.] Univ Colorado, CIRES NSIDC, Boulder, CO 80309 USA. [Shevchenko, Vladimir P.] PP Shirshov Inst Oceanol RAS, Moscow 117997, Russia. [Shiklomanov, Alexander I.] Univ New Hampshire, Inst Study Earth Oceans & Space, Durham, NH 03824 USA. [Shmakin, Andrey B.] Inst Geog, Moscow 119017, Russia. [Skold, Peter] Umea Univ, Ctr Sami Res, SE-90187 Umea, Sweden. [Sturm, Matthew] USA CRREL Alaska, Ft Wainwright, AK 99703 USA. [Woo, Ming-ko] McMaster Univ, Sch Geog & Earth Sci, W Hamilton, ON L8S 4K1, Canada. [Wood, Eric F.] Princeton Univ, Dept Civil & Environm Engn, Princeton, NJ 08544 USA. RP Callaghan, TV (reprint author), Royal Swedish Acad Sci, S-10405 Stockholm, Sweden. EM terry_callaghan@btinternet.com; margareta.johansson@nateko.lu.se; ross.brown@ec.gc.ca; Pasha.Groisman@noaa.gov; n.labba@gmail.com; vradion@aari.ru; rbradley@geo.umass.edu; sblangy@gmail.com; bulygina@meteo.ru; torben.christensen@nateko.lu.se; j.e.colman@bio.uio.no; ressery@staffmail.ed.ac.uk; bforbes@ulapland.fi; mcf@dmu.dk; golubev@geol.msu.ru; gjuday@alsaska.edu; meschers@main.mgo.rssi.ru; g.phoenix@sheffield.ac.uk; john.pomeroy@usask.ca; arja.rautio@oulu.fi; david.robinson@rutgers.edu; nms@dmu.dk; serreze@nsidc.org; vshevch@ocean.ru; Alex.Shiklomanov@unh.edu; ashmakin@igras.ru; peter.skold@cesam.umu.se; Matthew.Sturm@usace.army.mil; woo@mcmaster.ca; efwood@princeton.edu RI Golubev, Vladimir/K-1678-2012; Pomeroy, John/A-8589-2013; Forchhammer, Mads/I-7474-2013; Schmidt, Niels Martin/G-3843-2011; Forbes, Bruce/L-4431-2013; Meshcherskaya, Anna/D-2807-2016; Bulygina, Olga/H-1251-2016; Callaghan, Terens/N-7640-2014; OI Phoenix, Gareth/0000-0002-0911-8107; Essery, Richard/0000-0003-1756-9095; Pomeroy, John/0000-0002-4782-7457; Schmidt, Niels Martin/0000-0002-4166-6218; Forbes, Bruce/0000-0002-4593-5083; Shevchenko, Vladimir/0000-0002-9045-297X FU Swedish Environmental Protection Agency [08/210]; Swedish Research Council FORMAS [204-2009-45] FX The authors wish to thank the various national funding agencies that made this review possible, specifically the Swedish Environmental Protection Agency (grant number 08/210) and the Swedish Research Council FORMAS (grant number 204-2009-45) who helped directly support this publication. The authors also gratefully acknowledge the Arctic Monitoring and Assessment Program Secretariat and the SWIPA Integration Team in helping to produce the original SWIPA report and the various contributing SWIPA chapter authors. Finally, the authors thank reviewers of the SWIPA snow chapter, particularly Barry Goodison. NR 99 TC 42 Z9 44 U1 11 U2 119 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0044-7447 J9 AMBIO JI Ambio PD DEC PY 2011 VL 40 SU 1 BP 32 EP 45 DI 10.1007/s13280-011-0213-x PG 14 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 959BM UT WOS:000305284800005 ER PT J AU Fekadu, N Zaghloul, AI AF Fekadu, Nassissie Zaghloul, Amir I. TI FEKO/NEC2 Simulation of Candidate Antennas for the Long Wavelength Array (LWA) SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article DE Blade; dipole-like structures; FEKO; fork; mutual coupling; tied-fork AB This paper presents FEKO and NEC-2 simulations done on three dipole-like structures; the big blade, the tied-fork and the fork antenna. These antenna elements are considered for the design of the long wavelength array (LWA). The LWA is an interferometer under construction in New Mexico, USA for astronomical observations in the 20 - 80 MHz spectrum. This paper presents the simulation results of a co-polarized antenna gain patterns, impedance values, and mutual couplings for each candidate elements. Coupling results from FEKO and NEC-2 simulations are compared with measurement result of the big blade antenna. The paper also presents S-parameters for 25 elements of the tied-fork antennas. C1 [Fekadu, Nassissie; Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. [Fekadu, Nassissie] Noblis, Falls Church, VA 22042 USA. [Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA. RP Fekadu, N (reprint author), Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA. EM nfekadu@vt.edu; amirz@vt.edu FU Virginia Polytechnic Institute and State University FX The authors wish to acknowledge the support of Dr. S. Ellingson of Virginia Polytechnic Institute and State University, Dr. N. Kassim, Emil J. Polisensky, Ken Stewart and Henrique Schmitt of the Navy Research Laboratory in providing the measurement data needed for the analysis presented in this paper. NR 15 TC 0 Z9 0 U1 0 U2 2 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD DEC PY 2011 VL 26 IS 12 SI SI BP 963 EP 972 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 901ZH UT WOS:000301007900002 ER PT J AU Glanc, P Andreotti, RF Lee, SI Allison, SOD Bennett, GL Brown, DL Dubinsky, T Javitt, MC Mitchell, DG Podrasky, AE Shipp, TD Siegel, CL Wong-You-Cheong, JJ Zelop, CM AF Glanc, Phyllis Andreotti, Rochelle F. Lee, Susanna I. Allison, Sandra O. DeJesus Bennett, Genevieve L. Brown, Douglas L. Dubinsky, Theodore Javitt, Marcia C. Mitchell, Donald G. Podrasky, Ann E. Shipp, Thomas D. Siegel, Cary Lynn Wong-You-Cheong, Jade J. Zelop, Carolyn M. TI ACR Appropriateness Criteria (R) Assessment of Gravid Cervix SO ULTRASOUND QUARTERLY LA English DT Article DE appropriateness criteria; cervix; preterm birth; gravid; ultrasound ID ULTRASOUND-INDICATED CERCLAGE; PRETERM PREMATURE RUPTURE; TRANSVAGINAL ULTRASOUND; DIGITAL EXAMINATION; UTERINE CERVIX; TRANSFUNDAL PRESSURE; MICROBIAL INVASION; INCOMPETENT CERVIX; INTACT MEMBRANES; RANDOMIZED-TRIAL AB It is well recognized that preterm birth is the leading cause of perinatal mortality and morbidity. There is a significant association between cervix length and preterm birth risk. Most authorities consider a cervical length <3 cm as the lower limit of normal. A cervical length >3 cm has a high negative predictive value for delivery less than 34 weeks. A cervical length of <15 mm is moderately predictive (similar to 70%) of preterm birth within 48 hours. Cervical length is normally distributed and should remain relatively constant until the third trimester. Transabdominal US is the least reliable method of cervical length assessment. The most reliable method of documenting cervical length is transvaginal ultrasound (TVUS). Transperineal US is an alternative for imaging if TVUS is contraindicated, such as with premature rupture of membranes. However, the resolution is decreased compared to TVUS. Short cervix length is the single most important predictive finding for premature delivery. This observation should prompt consultation for high risk obstetrical care and consideration of other management options such as cerclage or activity restriction. The ACR Appropriateness Criteria (R) are evidence-based guidelines for specific clinical conditions that are reviewed biennially by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging. C1 [Glanc, Phyllis] Sunnybrook Hlth Sci Ctr, Dept Med Imaging, Toronto, ON M4N 3M5, Canada. [Andreotti, Rochelle F.] Vanderbilt Univ, Med Ctr, Nashville, TN USA. [Lee, Susanna I.] Massachusetts Gen Hosp, Boston, MA 02114 USA. [Allison, Sandra O. DeJesus] Georgetown Univ Hosp, Washington, DC 20007 USA. [Bennett, Genevieve L.] NYU Med Ctr, New York, NY 10016 USA. [Brown, Douglas L.] Mayo Clin, Rochester, MN USA. [Dubinsky, Theodore] Univ Washington, Sch Med, Seattle, WA USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Mitchell, Donald G.] Thomas Jefferson Univ Hosp, Philadelphia, PA 19107 USA. [Podrasky, Ann E.] Baptist Hosp Miami, S Miami Ctr Women & Infants, Miami, FL USA. [Shipp, Thomas D.] Diagnost Ultrasound Associates, Boston, MA USA. [Siegel, Cary Lynn] Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA. [Wong-You-Cheong, Jade J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. [Zelop, Carolyn M.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA. [Shipp, Thomas D.; Zelop, Carolyn M.] Amer Coll Obstetricians & Gynecologists, Washington, DC USA. RP Glanc, P (reprint author), Sunnybrook Hlth Sci Ctr, Dept Med Imaging, 2075 Bayview, Toronto, ON M4N 3M5, Canada. EM phyllis.glanc@sunnybrook.ca NR 51 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0894-8771 J9 ULTRASOUND Q JI Ultrasound Q. PD DEC PY 2011 VL 27 IS 4 BP 275 EP 280 DI 10.1097/RUQ.0b013e3182394123 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 893OY UT WOS:000300366400006 PM 22124410 ER PT J AU Tompkins, RP Walsh, TA Derenge, MA Kirchner, KW Zhou, S Nguyen, CB Jones, KA Suvarna, P Tungare, M Tripathi, N Shahedipour-Sandvik, F AF Tompkins, Randy P. Walsh, Timothy A. Derenge, Michael A. Kirchner, Kevin W. Zhou, Shuai Nguyen, Cuong B. Jones, Kenneth A. Suvarna, Puneet Tungare, Mihir Tripathi, Neeraj Shahedipour-Sandvik, Fatemeh (Shadi) TI The effect of carbon impurities on lightly doped MOCVD GaN Schottky diodes SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID TEMPERATURE; SUBSTRATE; MOVPE AB Schottky diodes have been fabricated on metalorganic chemical vapor deposition GaN epitaxial layers grown on sapphire substrates. Carbon impurities limit the ability of these films to be used in high-power devices. Although its effect can be mitigated by growing the films at higher pressure, higher flow rates, and larger V/III ratios, it still effectively limits the net carrier concentration to similar to 10(16) cm(-3) and therefore the breakdown voltage to similar to 1200 V by acting as a compensating deep acceptor for n-type material. The net carrier concentration is smaller than the carbon concentration indicating that not all of the carbon occupies a nitrogen site acting as a deep acceptor. It is not known whether some of the carbon occupies gallium sites acting as a donor, interstitial sites creating states in the midgap region, and/or is tied up in the large number of dislocations in the films where it is not electrically active. C1 [Tompkins, Randy P.; Walsh, Timothy A.; Derenge, Michael A.; Kirchner, Kevin W.; Zhou, Shuai; Nguyen, Cuong B.; Jones, Kenneth A.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Suvarna, Puneet; Tungare, Mihir; Tripathi, Neeraj; Shahedipour-Sandvik, Fatemeh (Shadi)] SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA. RP Tompkins, RP (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM randy.tompkins.ctr@mail.mil FU U.S. Army Research Laboratory FX The authors thank Dr. Steve Novak of SUNY-Albany for his assistance with secondary ion mass spectroscopy measurements and Dr. Andrew Allerman at Sandia and Dr. Joshua Robinson at Penn State for contributing some MOCVD-grown films. This work was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. NR 17 TC 9 Z9 9 U1 1 U2 15 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD DEC PY 2011 VL 26 IS 23 BP 2895 EP 2900 DI 10.1557/jmr.2011.360 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA 886SY UT WOS:000299875400002 ER PT J AU Rabago, CA Wilken, JM AF Rabago, Christopher A. Wilken, Jason M. TI Application of a Mild Traumatic Brain Injury Rehabilitation Program in a Virtual Realty Environment: A Case Study SO JOURNAL OF NEUROLOGIC PHYSICAL THERAPY LA English DT Article DE mild traumatic brain injury; postconcussive syndrome military; rehabilitation; virtual reality; visual vertigo ID STABILITY FOLLOWING CONCUSSION; SPATIAL ORIENTATION; POSTURAL STABILITY; VISUAL VERTIGO; HEAD-INJURY; BALANCE; REALITY; RELIABILITY; VALIDITY AB Background and Purpose: Mild traumatic brain injury (mTBI) can compromise reaction time, visual perception, memory, attention, balance, and gait. These deficits, especially if persistent, can restrict participation in daily activities and the resumption of personal and profession roles. The purpose of this case study is to describe an mTBI-specific clinical assessment and rehabilitation intervention administered in a virtual reality environment. Case Description: The case involved a 31-year-old male service member who had sustained an mTBI (concussion) during a recreational softball game 36 days prior to physical therapist evaluation. He had complaints of severe visual and physical motion intolerance. He demonstrated impaired static balance and was restricted from full military duty. Interventions: The assessment included measurements of postural and gait balance during cognitive, visual, and vestibular challenges within a Computer-Assisted Rehabilitation Environment. Phase 1 of the intervention consisted of clinical techniques (ie, optokinetic stimulation/habituation, visual/physical perturbations, and postural stability exercises) targeting specific impairments. Phase 2 training consisted of weapon handling and target recognition tasks to simulate the requirements of his military occupation. Outcomes: At the conclusion of 6 treatments, the patient demonstrated significant increases in postural and gait balance with a near complete resolution of all postconcussion symptoms. He successfully returned to full duty and training for combat deployment. Discussion: Service members and civilians exhibit similar impairments, limitations, and restrictions following mTBI. A rehabilitation program delivered in a virtual-reality environment can be structured to manage complex mTBI symptoms through the integration of multiple treatment modalities specific to a patient's personal and professional roles. C1 [Rabago, Christopher A.; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ctr Intrepid, Ft Sam Houston, TX 78234 USA. RP Rabago, CA (reprint author), Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ctr Intrepid, 3851 Roger Brooke Drv, Ft Sam Houston, TX 78234 USA. EM Christopher.Rabago@amedd.army.mil OI Wilken, Jason/0000-0002-5556-7667; Rabago, Christopher/0000-0002-4484-0613 FU Medical Research and Material Command's Military Operational Medicine Research Program; Brooke Army Medical Center's traumatic brain injury service FX Support provided by Medical Research and Material Command's Military Operational Medicine Research Program (to J.M.W.).; We thank our CAREN application designer, Michael Vernon, for his technical expertise in the development of treatment applications; Mustafa Shinta for data collection assistance; Dr Tedesco-Evans and Mrs Marina LeBlanc for the patient referral; and all the providers at Brooke Army Medical Center's traumatic brain injury service for their support. NR 31 TC 18 Z9 20 U1 2 U2 25 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1557-0576 J9 J NEUROL PHYS THER JI J. Neurol. Phys. Ther. PD DEC PY 2011 VL 35 IS 4 BP 185 EP 193 DI 10.1097/NPT.0b013e318235d7e6 PG 9 WC Clinical Neurology; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 890YU UT WOS:000300183800006 PM 22027473 ER PT J AU Reschke, BR Timperman, AT AF Reschke, Brent R. Timperman, Aaron T. TI A Study of Electrospray Ionization Emitters with Differing Geometries with Respect to Flow Rate and Electrospray Voltage SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY LA English DT Article DE Electrospray ionization; Etched open-tubular emitter; Polymeric emitter; Pulled tip emitter; Electrospray voltage; Flow rate; Reserpine ID CAPILLARY-ZONE-ELECTROPHORESIS; CHROMATOGRAPHY MASS-SPECTROMETRY; LIQUID-CHROMATOGRAPHY; NANOFLOW REGIME; ION-SPRAY; NANOELECTROSPRAY IONIZATION; PRACTICAL CONSIDERATIONS; MICROFLUIDIC DEVICE; MICRO-ELECTROSPRAY; SAMPLE INJECTION AB The performance of several electrospray ionization emitters with different orifice inside diameters (i.d.s), geometries, and materials are compared. The sample solution is delivered by pressure driven flow, and the electrospray ionization voltage and flow rate are varied systematically for each emitter investigated, while the signal intensity of a standard is measured. The emitters investigated include a series of emitters with a tapered outside diameters (o.d.) and unaltered i.d.s, a series of emitters with tapered o.d.s and i.d.s, an emitter with a monolithic frit and a tapered o.d., and an emitter fabricated from polypropylene. The results show that for the externally etched emitters, signal was nearly independent of i.d. and better ion utilization was achieved at lower flow rates. Furthermore, emitters with a 50 mu m i.d. and an etched o.d. produced about 1.5 times more signal than etched emitters with smaller i.d.s and about 3.5 times more signal than emitters with tapered inner and outer dimensions. Additionally, the work presented here has important implications for applications in which maximizing signal intensity and reducing frictional resistance to flow are necessary. Overall, the work provides an initial assessment of the critical parameters that contribute to maximizing the signal for electrospray ionization sources interfaced with pressure driven flows. C1 [Timperman, Aaron T.] Engineer Res & Dev Ctr ERDC, Construct Engn Res Lab CERL, Champaign, IL 61826 USA. [Reschke, Brent R.] W Virginia Univ, C Eugene Bennet Dept Chem, Morgantown, WV 26506 USA. RP Timperman, AT (reprint author), Engineer Res & Dev Ctr ERDC, Construct Engn Res Lab CERL, 2902 Newmark Dr, Champaign, IL 61826 USA. EM aaron.timperman@usace.army.mil FU WVU; WVNano program; NSF RII [EPS 0554328]; WV EPSCoR Office; WVU Research Corp. FX The authors acknowledge that the research was performed at West Virginia University, and thank WVU and the WVNano program for support. The authors also acknowledge that this work is funded in part through NSF RII award EPS 0554328, for which the WV EPSCoR Office and the WVU Research Corp. provided matching funds. We would like to thank Akos Vertes for enlightening discussions about ESI. NR 72 TC 9 Z9 9 U1 3 U2 46 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1044-0305 J9 J AM SOC MASS SPECTR JI J. Am. Soc. Mass Spectrom. PD DEC PY 2011 VL 22 IS 12 BP 2115 EP 2124 DI 10.1007/s13361-011-0251-4 PG 10 WC Biochemical Research Methods; Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy GA 893MQ UT WOS:000300360400004 PM 21989703 ER PT J AU Heath, NM Lynch, SM Fritch, AM McArthur, LN Smith, SL AF Heath, Nicole M. Lynch, Shannon M. Fritch, April M. McArthur, Lyn N. Smith, Shilo L. TI Silent Survivors: Rape Myth Acceptance in Incarcerated Women's Narratives of Disclosure and Reporting of Rape SO PSYCHOLOGY OF WOMEN QUARTERLY LA English DT Article DE rape; sexual abuse; abuse reporting; victimization; self-disclosure; social support; stigma ID SEXUAL ASSAULT SURVIVORS; SOCIAL REACTIONS; COLLEGE-WOMEN; VICTIMS; VICTIMIZATION; ATTRIBUTIONS; EXPERIENCES; POLICE; HEALTH; REVICTIMIZATION AB Prior research suggests that rape victims who do not disclose or report to the police give reasons including self-blame and fear of judgment; however, this research has not been conducted with incarcerated women. Female offenders are a unique population because they experience high rates of sexual assault prior to incarceration. This study recruited 74 women at a U.S. state prison, who experienced sexual assault prior to incarceration to explore the associations among rape myth acceptance (RMA), disclosure, and reporting of sexual assaults to the authorities. Participants were asked open-ended questions regarding why they chose to disclose their sexual assaults to others, to report to the police, or to remain silent. Narratives were audio-taped, transcribed, and coded for thematic content. Women's narratives, particularly those of women who indicated that they remained silent, frequently included a variety of rape myths that involved blaming themselves for the rape, fearing not being believed, believing that familiar perpetrators cannot be rapists, and questioning whether the event was really a rape. Women often described such rape myth beliefs with greater frequency than discussing situational characteristics of the rape as reasons for nonreporting. Implications for these findings in clinical, research, and social justice contexts are discussed. C1 [Heath, Nicole M.] Rush Univ, Dept Behav Sci, Med Ctr, Chicago, IL 60612 USA. [Lynch, Shannon M.; McArthur, Lyn N.] Idaho State Univ, Dept Psychol, Pocatello, ID 83209 USA. [Fritch, April M.] Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. [Smith, Shilo L.] Coll So Idaho, Dept Psychol, Twin Falls, ID USA. RP Heath, NM (reprint author), Rush Univ, Dept Behav Sci, Med Ctr, 1645 W Jackson,Suite 400, Chicago, IL 60612 USA. EM Nicole_Heath@rush.edu NR 58 TC 7 Z9 7 U1 2 U2 23 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0361-6843 J9 PSYCHOL WOMEN QUART JI Psychol. Women Q. PD DEC PY 2011 VL 35 IS 4 BP 596 EP 610 DI 10.1177/0361684311407870 PG 15 WC Psychology, Multidisciplinary; Women's Studies SC Psychology; Women's Studies GA 890OQ UT WOS:000300154500005 ER PT J AU Gramann, K Gwin, JT Ferris, DP Oie, K Jung, TP Lin, CT Liao, LD Makeig, S AF Gramann, Klaus Gwin, Joseph T. Ferris, Daniel P. Oie, Kelvin Jung, Tzyy-Ping Lin, Chin-Teng Liao, Lun-De Makeig, Scott TI Cognition in action: imaging brain/body dynamics in mobile humans SO REVIEWS IN THE NEUROSCIENCES LA English DT Article DE EEG; embodied cognition; independent component analysis (ICA); mobile brain imaging; wireless dry electrodes ID HUMAN POSTURAL CONTROL; SPINAL-CORD-INJURY; TRANSCRANIAL MAGNETIC STIMULATION; SUPRASPINAL LOCOMOTOR CONTROL; ALLOCENTRIC REFERENCE FRAMES; NEAR-INFRARED SPECTROSCOPY; SLEEP-DEPRIVED SUBJECTS; EVOKED MOTOR-RESPONSES; NECK MUSCLE VIBRATION; HUMAN STANCE CONTROL AB We have recently developed a mobile brain imaging method (MoBI), that allows for simultaneous recording of brain and body dynamics of humans actively behaving in and interacting with their environment. A mobile imaging approach was needed to study cognitive processes that are inherently based on the use of human physical structure to obtain behavioral goals. This review gives examples of the tight coupling between human physical structure with cognitive processing and the role of supraspinal activity during control of human stance and locomotion. Existing brain imaging methods for actively behaving participants are described and new sensor technology allowing for mobile recordings of different behavioral states in humans is introduced. Finally, we review recent work demonstrating the feasibility of a MoBI system that was developed at the Swartz Center for Computational Neuroscience at the University of California, San Diego, demonstrating the range of behavior that can be investigated with this method. C1 [Gramann, Klaus; Jung, Tzyy-Ping; Makeig, Scott] Univ Calif San Diego, Swartz Ctr Computat Neurosci, Inst Neural Computat, San Diego, CA 92103 USA. [Gwin, Joseph T.; Ferris, Daniel P.] Univ Michigan, Human Neuromech Lab, Sch Kinesiol, Ann Arbor, MI 48109 USA. [Oie, Kelvin] USA, Translat Neurosci Branch, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD USA. [Gramann, Klaus; Jung, Tzyy-Ping; Lin, Chin-Teng; Liao, Lun-De] Natl Chiao Tung Univ, Brain Res Ctr, Hsinchu, Taiwan. [Lin, Chin-Teng; Liao, Lun-De] Natl Chiao Tung Univ, Dept Comp Sci, Hsinchu, Taiwan. RP Gramann, K (reprint author), Univ Calif San Diego, Swartz Ctr Computat Neurosci, Inst Neural Computat, San Diego, CA 92103 USA. EM klaus@sccn.ucsd.edu RI Oie, Kelvin/J-4382-2012; Ferris, Daniel/A-9624-2008 OI Ferris, Daniel/0000-0001-6373-6021 FU Swartz Foundation (Old Field, NY; National Science Foundation, USA [NSF IIS-0613595, TDLC-0542013]; National Chiao Tung University; Ministry of Education, Taiwan; UST-UCSD International Center of Excellence in Advanced Bio-engineering; Taiwan National Science Council [NSC-99-2911-I-009-101]; Army Research Laboratory [W911NF-10-2-0022] FX This work was supported by a gift from the Swartz Foundation (Old Field, NY) and by grants from the National Science Foundation, USA (NSF IIS-0613595, TDLC-0542013), the Aiming for the Top University Plan of National Chiao Tung University, the Ministry of Education, Taiwan, the UST-UCSD International Center of Excellence in Advanced Bio-engineering sponsored by the Taiwan National Science Council I-RiCE Program under Grant Number NSC-99-2911-I-009-101, and the Army Research Laboratory under Cooperative Agreement Number W911NF-10-2-0022. The views and the conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the US Government. The US Government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation herein. NR 166 TC 53 Z9 54 U1 2 U2 22 PU WALTER DE GRUYTER GMBH PI BERLIN PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY SN 0334-1763 EI 1607-8470 J9 REV NEUROSCIENCE JI Rev. Neurosci. PD DEC PY 2011 VL 22 IS 6 BP 593 EP 608 DI 10.1515/RNS.2011.047 PG 16 WC Neurosciences SC Neurosciences & Neurology GA 889QH UT WOS:000300087800002 PM 22070621 ER PT J AU West, BJ AF West, Bruce J. TI NETWORKS AND 1/f NOISE SO FLUCTUATION AND NOISE LETTERS LA English DT Article DE Complex networks; power laws; complexity management; decision making ID NEURONAL AVALANCHES; RENEWAL PROCESSES; COMPLEX NETWORKS; SYNCHRONIZATION; FLUCTUATIONS; DYNAMICS AB Complex networks form one of the most challenging areas of modern research overarching the traditional scientific disciplines. Of particular importance is the manner in which information is shuttled back and forth between such networks, and whether or not there exists general principles that guide the flow of information. Herein, we identify Wiener's rule, which conjectures how information is transfered in an information-dominated process. Moreover, we show that this rule is a consequence of the Principle of Complexity Management (PCM) that determines the information exchange between complex networks. A consequence of the PCM is that the maximum information transfer occurs at a 1/f noise resonance. The information transfer between two complex networks is also determined by direct numerical calculation of a master equation model of network dynamics using interacting two-state elements, the decision-making model (DMM). The DMM generates phase transitions and on a two-dimensional lattice, reduces to the Ising model in an appropriate limit. The computations using the DMM suggest that the inverse power laws of links and survival probability are not necessarily related. C1 USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP West, BJ (reprint author), USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. EM bruce.j.west.civ@mail.mil NR 47 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE SN 0219-4775 J9 FLUCT NOISE LETT JI Fluct. Noise Lett. PD DEC PY 2011 VL 10 IS 4 BP 515 EP 531 DI 10.1142/S0219477511000703 PG 17 WC Mathematics, Interdisciplinary Applications; Physics, Applied SC Mathematics; Physics GA 884WQ UT WOS:000299740000014 ER PT J AU Swab, JJ Yu, J Gamble, R Kilczewski, S AF Swab, Jeffrey J. Yu, Jian Gamble, Robert Kilczewski, Steve TI Analysis of the diametral compression method for determining the tensile strength of transparent magnesium aluminate spinel SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article DE Diametral compression; Tensile strength; Fracture analysis; Magnesium aluminate spinel ID IMAGE CORRELATION PHOTOGRAMMETRY; FIELD DYNAMIC DISPLACEMENT; CERAMICS AB Attempts were made to determine the inherent tensile strength of a coarse-grained, hot-pressed magnesium aluminate spinel (MgAl(2)O(4)) using the diametral compression test. Thick (9.6 mm) disk specimens were machined from a large (356 mm square) plate of spinel. Two pairs of tungsten carbide (WC) platens, one with flat surfaces and the other with a 20. half-arc and radius matched to the disk diameter, were used to transfer the applied load. Specimens tested using the platens with the matched radius had strength values almost 50% higher than those tested using flat platens. Images of the fracture process captured using a high-speed camera showed that irrespective of the type of platens used, fracture consistently initiated at the loading interface, resulting in an invalid test. These results show that the diametral compression test method is not appropriate for determining the tensile strength of this spinel and it raises concerns about the applicability of the method for any advanced ceramic. C1 [Swab, Jeffrey J.] USA, Res Lab, Aberdeen, MD USA. [Yu, Jian] Oak Ridge Inst Sci & Educ, Oak Ridge, TN USA. [Gamble, Robert] Bowhead DSI, Alexandria, VA USA. [Kilczewski, Steve] Data Matrix Syst, Sterling, VA USA. RP Swab, JJ (reprint author), USA, Res Lab, Aberdeen, MD USA. EM jeffrey.j.swab.civ@mail.mil NR 21 TC 9 Z9 9 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD DEC PY 2011 VL 172 IS 2 BP 187 EP 192 DI 10.1007/s10704-011-9655-1 PG 6 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA 883GA UT WOS:000299621000005 ER PT J AU Inaba, K Branco, BC Rhee, P Blackbourne, LH Holcomb, JB Spinella, PC Shulman, I Nelson, J Demetriades, D AF Inaba, Kenji Branco, Bernardino C. Rhee, Peter Blackbourne, Lorne H. Holcomb, John B. Spinella, Philip C. Shulman, Ira Nelson, Janice Demetriades, Demetrios TI Impact of the Duration of Platelet Storage in Critically Ill Trauma Patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Meeting on Advanced Technology Applications for Combat Casualty Care (ATACCC) CY AUG 16-19, 2010 CL St Pete Beach, FL DE Trauma; Transfusion; Platelets; Duration of storage; Outcome; Complications; Sepsis ID RED-CELL STORAGE; UNIVERSAL LEUKOREDUCTION; INDEPENDENT PREDICTOR; TRANSFUSED PLATELETS; APHERESIS PLATELETS; BLOOD-TRANSFUSION; IMPROVED SURVIVAL; CARDIAC-SURGERY; SEVERE INJURY; WHOLE-BLOOD AB Background: There is increasing evidence that the duration of red blood cell (RBC) storage negatively impacts outcomes. Data regarding prolonged storage of other blood components, however, are lacking. The aim of this study was to evaluate how the duration of platelet storage affects trauma patient outcomes. Methods: Trauma patients admitted to a Level I trauma center requiring platelet transfusion (2006-2009) were retrospectively identified. Apheresis platelets (aPLT) containing >= 3 x 10(11) platelets/unit were used exclusively. Patients were analyzed in three groups: those who received only aPLT stored for <= 3 days, 4 days, and 5 days. The outcomes included mortality and complications (sepsis, acute respiratory distress syndrome, renal, and liver failure). Results: Three hundred eighty-one patients were available for analysis (128 received aPLT <= 3 days old; 109 = 4 days old; and 144 = 5 days old). There were no significant demographic differences between groups. Patients receiving aPLT aged = 4 days had significantly higher Injury Severity Score (p = 0.022) and were more likely to have a head Abbreviated Injury Scale >= 3 (p = 0.014). There were no differences in volumes transfused or age of RBC, plasma, cryoprecipitate, or factor VIIa. After adjusting for confounders, exposure to older aPLT did not impact mortality; however, with increasing age, complications were significantly higher. The rate of sepsis, in particular, was significantly increased (5.5% for aPLT <= 3 days vs. 9.2% for aPLT = 4 days vs. 16.7% for aPLT = 5 days, adjusted p = 0.033). For acute respiratory distress syndrome and renal and liver failure, similar trends were observed. Conclusions: In critically ill trauma patients, there was a stepwise increase in complications, in particular sepsis, with exposure to progressively older platelets. Further evaluation of the underlying mechanism and methods for minimizing exposure to older platelets is warranted. C1 [Inaba, Kenji; Branco, Bernardino C.; Demetriades, Demetrios] Univ So Calif, Div Trauma & Surg Crit Care, Los Angeles, CA 90033 USA. [Rhee, Peter] Univ Arizona, Div Trauma Crit Care & Emergency Surg, Tucson, AZ USA. [Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. [Holcomb, John B.] Univ Texas Med Sch Houston, Ctr Translat Injury Res, Div Acute Care Surg, Houston, TX USA. [Spinella, Philip C.] Washington Univ, St Louis Childrens Hosp, Dept Pediat, Div Pediat Crit Care, St Louis, MO 63110 USA. [Shulman, Ira; Nelson, Janice] Univ So Calif, Med Ctr, Dept Pathol, Los Angeles, CA 90033 USA. RP Inaba, K (reprint author), Univ So Calif, Div Trauma & Surg Crit Care, 1200 N State St,Room CL5100, Los Angeles, CA 90033 USA. EM kinaba@surgery.usc.edu NR 32 TC 21 Z9 21 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2011 VL 71 IS 6 BP 1766 EP 1773 DI 10.1097/TA.0b013e31823bdbf9 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 869RT UT WOS:000298616400059 PM 22182887 ER PT J AU Crump, C Silvers, CT Wilson, B Schlachta-Fairchild, L Lingley-Papadopoulos, CA Ashley, JS AF Crump, Cindy Silvers, Christine Tsien Wilson, Bruce Schlachta-Fairchild, Loretta Lingley-Papadopoulos, Colleen A. Ashley, Jeffrey S. TI Using Principal Component Analysis to Aid Bayesian Network Development for Prediction of Critical Care Patient Outcomes SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Critical care outcome prediction; Principal component analysis; Bayesian networks; Intensive care unit patient outcomes ID ABLE-BODIED GAIT; TRAUMA PATIENTS; WAVE-FORMS; MULTICENTER; SURVIVAL; INJURIES; MODELS; STROKE; TRISS AB Background: Predicting an intensive care unit patient's outcome is highly desirable. An end goal is for computational techniques to provide updated, accurate predictions about changing patient condition using a manageable number of physiologic parameters. Methods: Principal component analysis was used to select input parameters for critical care patient outcome models. Vital signs and laboratory values from each patient's hospital stay along with outcomes ("Discharged" vs. "Deceased") were collected retrospectively at a Level I Trauma-Military Medical Center in the southwest; intensive care unit patients were included if they had been admitted for burn, infection, or hypovolemia during a 5-year period ending October 2007. Principal component analysis was used to determine which of the 24 parameters would serve as inputs in a Bayesian network developed for outcome prediction. Results: Data for 581 patients were collected. Pulse pressure, heart rate, temperature, respiratory rate, sodium, and chloride were found to have statistically significant differences between Discharged and Deceased groups for "Hypovolemia" patients. For "Burn" patients, pulse pressure, hemoglobin, hematocrit, and potassium were found to have statistically significant differences. For a "Combined" group, heart rate, temperature, respiratory rate, sodium, and chloride had statistically significant differences. A Bayesian network based on these results, developed for the Combined group, achieved an accuracy of 75% when predicting patient outcome. Conclusions: Outcome prediction for critical care patients is possible. Future work should explore model development using additional temporal data and should include prospective validation. Such technology could serve as the basis of real-time intelligent monitoring systems for critical patients. C1 [Crump, Cindy; Silvers, Christine Tsien; Wilson, Bruce; Lingley-Papadopoulos, Colleen A.] AFrame Digital Inc, Reston, VA USA. [Silvers, Christine Tsien] Childrens Hosp, Informat Program, Boston, MA 02115 USA. [Schlachta-Fairchild, Loretta] iTelehealth, Frederick, MD USA. [Ashley, Jeffrey S.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Crump, C (reprint author), 1889 Preston White Dr,Suite 101, Reston, VA 20191 USA. EM ccrump@aframedigital.com FU Defense Advanced Research Projects Agency [W31P4Q-06-C-0016] FX Supported by Defense Advanced Research Projects Agency via research contract W31P4Q-06-C-0016. NR 31 TC 2 Z9 2 U1 2 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2011 VL 71 IS 6 BP 1841 EP 1849 DI 10.1097/TA.0b013e3182250184 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 869RT UT WOS:000298616400072 PM 22182894 ER PT J AU Stannard, A Eliason, JL Rasmussen, TE AF Stannard, Adam Eliason, Jonathan L. Rasmussen, Todd E. TI Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) as an Adjunct for Hemorrhagic Shock SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID ABDOMINAL-TRAUMA; MODEL C1 [Stannard, Adam; Rasmussen, Todd E.] USA, Inst Surg Res, Ft Sam Houston, TX 78236 USA. [Stannard, Adam] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Eliason, Jonathan L.] Univ Michigan Hlth Syst, Dept Surg, Vasc Surg Sect, Ann Arbor, MI USA. [Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Suite B, Ft Sam Houston, TX 78236 USA. EM todd.rasmussen@amedd.army.mil NR 6 TC 87 Z9 88 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2011 VL 71 IS 6 BP 1869 EP 1872 DI 10.1097/TA.0b013e31823fe90c PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 869RT UT WOS:000298616400074 PM 22182896 ER PT J AU Plackett, TP Barmparas, G Inaba, K Demetriades, D AF Plackett, Timothy P. Barmparas, Galinos Inaba, Kenji Demetriades, Demetrios TI Transplantation for Severe Hepatic Trauma SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review ID SEVERE LIVER TRAUMA; 2-STAGE TOTAL HEPATECTOMY; TERM-FOLLOW-UP; ABDOMINAL-TRAUMA; SINGLE-CENTER; VENA-CAVA; MANAGEMENT; INJURY; SECONDARY; AVULSION C1 [Plackett, Timothy P.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Barmparas, Galinos; Inaba, Kenji; Demetriades, Demetrios] Los Angeles Cty Univ So Calif Med Ctr, Dept Surg, Los Angeles, CA USA. RP Plackett, TP (reprint author), Womack Army Med Ctr, Dept Surg, 2417 Reilly Rd, Ft Bragg, NC 28307 USA. EM timothy.plackett@us.army.mil NR 35 TC 5 Z9 6 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 2011 VL 71 IS 6 BP 1880 EP 1884 DI 10.1097/TA.0b013e31822b1035 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 869RT UT WOS:000298616400077 PM 22182899 ER PT J AU Terra, JK France, B Cote, CK Jenkins, A Bozue, JA Welkos, SL Bhargava, R Ho, CL Mehrabian, M Pan, C Lusis, AJ Davis, RC LeVine, SM Bradley, KA AF Terra, Jill K. France, Bryan Cote, Christopher K. Jenkins, Amy Bozue, Joel A. Welkos, Susan L. Bhargava, Ragini Ho, Chi-Lee Mehrabian, Margarete Pan, Calvin Lusis, Aldons J. Davis, Richard C. LeVine, Steven M. Bradley, Kenneth A. TI Allelic Variation on Murine Chromosome 11 Modifies Host Inflammatory Responses and Resistance to Bacillus anthracis SO PLOS PATHOGENS LA English DT Article ID MOLECULAR-GENETIC ANALYSIS; QUANTITATIVE TRAIT LOCI; LETHAL TOXIN; ANTIINFLAMMATORY RESPONSE; STERNE STRAIN; CUTTING EDGE; DIABETES SUSCEPTIBILITY; SALMONELLA-TYPHIMURIUM; FRANCISELLA-TULARENSIS; MACROPHAGE APOPTOSIS AB Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence factors such as lethal toxin (LT), as well as by genetic variation within the host. To identify host genes controlling susceptibility to anthrax, a library of congenic mice consisting of strains with homozygous chromosomal segments from the LT-responsive CAST/Ei strain introgressed on a LT-resistant C57BL/6 (B6) background was screened for response to LT. Three congenic strains containing CAST/Ei regions of chromosome 11 were identified that displayed a rapid inflammatory response to LT similar to, but more severe than that driven by a LT-responsive allele of the inflammasome constituent NRLP1B. Importantly, increased response to LT in congenic mice correlated with greater resistance to infection by the Sterne strain of B. anthracis. The genomic region controlling the inflammatory response to LT was mapped to 66.36-74.67 Mb on chromosome 11, a region that encodes the LT-responsive CAST/Ei allele of Nlrp1b. However, known downstream effects of NLRP1B activation, including macrophage pyroptosis, cytokine release, and leukocyte infiltration could not fully explain the response to LT or the resistance to B. anthracis Sterne in congenic mice. Further, the exacerbated response in congenic mice is inherited in a recessive manner while the Nlrp1b-mediated response to LT is dominant. Finally, congenic mice displayed increased responsiveness in a model of sepsis compared with B6 mice. In total, these data suggest that allelic variation of one or more chromosome 11 genes in addition to Nlrp1b controls the severity of host response to multiple inflammatory stimuli and contributes to resistance to B. anthracis Sterne. Expression quantitative trait locus analysis revealed 25 genes within this region as high priority candidates for contributing to the host response to LT. C1 [Terra, Jill K.; France, Bryan; Bhargava, Ragini; Ho, Chi-Lee; Lusis, Aldons J.; Bradley, Kenneth A.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90024 USA. [Cote, Christopher K.; Jenkins, Amy; Bozue, Joel A.; Welkos, Susan L.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. [Mehrabian, Margarete; Pan, Calvin; Lusis, Aldons J.] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA. [Lusis, Aldons J.; Davis, Richard C.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [LeVine, Steven M.] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA. RP Terra, JK (reprint author), Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90024 USA. EM kbradley@microbio.ucla.edu FU NIH [2-T32-AI-07323, AI077791, HL28481]; JSTO-CBD/DTRA [CBM VAXBT-03-10-RDP004]; NIH/NIAID [AI028697] FX This research was supported by NIH grants 2-T32-AI-07323 (JKT), AI077791 (KAB and SML), and HL28481 (AJL). The USAMRIID research described in this paper was supported by JSTO-CBD/DTRA project #CBM VAXBT-03-10-RDP004 (CKC, AJ, JB, and SLW). We further acknowledge the Immuno/BioSpot & Cytometrics Core in the UCLA Center for AIDS Research (CFAR) supported by NIH/NIAID AI028697. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 73 TC 9 Z9 10 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD DEC PY 2011 VL 7 IS 12 AR e1002469 DI 10.1371/journal.ppat.1002469 PG 14 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 876LH UT WOS:000299108500068 PM 22241984 ER PT J AU Ward, MP Semel, B Jablonski, C Deutsch, C Giammaria, V Miller, SB Mcguire, BM AF Ward, Michael P. Semel, Brad Jablonski, Cindi Deutsch, Charlie Giammaria, Vincent Miller, Sarah B. Mcguire, Benjamin M. TI Consequences of using Conspecific Attraction in Avian Conservation: A Case Study of Endangered Colonial Waterbirds SO WATERBIRDS LA English DT Article DE conspecific attraction; Forster's Tern; Least Tern; nest predators ID LEAST TERNS; COMMON TERNS; SITE; POPULATIONS; SONGBIRDS; AGE AB Through the use of conspecific models and vocalizations, populations of conservation concern can be established in locations where limiting factors may be controlled or mitigated, assuming managers can both identify and create high-quality locations. From 2003 to 2008, conspecific attraction was used to establish populations of the state-endangered Forster's Tern (Sterna forsteri) in northeastern Illinois, USA. In 2009 and 2010, similar techniques were used with the federally-threatened Least Tern, (Sternula antillarum) near the confluence of the Missouri and Mississippi Rivers in Missouri, USA. At both locations, managers attempted to control factors that may limit tern reproductive success. While in most cases nesting populations were established, in some cases resulting in the greatest documented reproductive success in the region for decades, nest predation the year after the colonies were established was significantly higher than in the year the colony was established. The establishment of colonies attracted a variety of predators, some of which gained access to the colonies and predated tern nests. Conspecific attraction behavior may be a strategy used by birds to stay "one step ahead" of nest predators, and the repeated use of conspecific attraction by managers may result in individuals nesting at a site with high rates of nest predation. As a conservation tool, conspecific attraction should only be used in situations where nest predators can be effectively controlled. Received 4 May 2011, accepted 22 July 2011. C1 [Ward, Michael P.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Semel, Brad] Illinois Dept Nat Resources, Spring Grove, IL 60081 USA. [Jablonski, Cindi] Appl Ecol Serv, Brodhead, WI 53520 USA. [Deutsch, Charlie; Giammaria, Vincent; Miller, Sarah B.; Mcguire, Benjamin M.] US Army Corps Engineers, Rivers Project Off, W Alton, MO 63386 USA. RP Ward, MP (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, 1102 S Goodwin Ave, Urbana, IL 61801 USA. EM mpward@illinois.edu FU Illinois Department of Natural Resources; Zoos for Environmental Conservation; U.S. Army Corps of Engineers FX Funding was provided by the Illinois Department of Natural Resources, Zoos for Environmental Conservation, and the U.S. Army Corps of Engineers. We thank the McHenry County Conservation District and the Lake County Forest Preserve District for access to their natural areas, and the Fox Waterway Agency for creating the island at Grass Lake. We thank two anonymous reviewers for comments on the manuscript. NR 26 TC 5 Z9 5 U1 0 U2 19 PU WATERBIRD SOC PI WASHINGTON PA NATL MUSEUM NATURAL HISTORY SMITHSONIAN INST, WASHINGTON, DC 20560 USA SN 1524-4695 J9 WATERBIRDS JI Waterbirds PD DEC PY 2011 VL 34 IS 4 BP 476 EP 480 PG 5 WC Ornithology SC Zoology GA 881CQ UT WOS:000299458500010 ER PT J AU Esquivel, J Sticca, R Sugarbaker, P Levine, E Yan, TD Alexander, R Baratti, D Bartlett, D Barone, R Barrios, P Bieligk, S Bretcha-Boix, P Chang, CK Chu, F Chu, Q Daniel, S deBree, E Deraco, M Dominguez-Parra, L Elias, D Flynn, R Foster, J Garofalo, A Gilly, FN Glehen, O Gomez-Portilla, A Gonzalez-Bayon, L Gonzalez-Moreno, S Goodman, M Gushchin, V Hanna, N Hartmann, J Harrison, L Hoefer, R Kane, J Kecmanovic, D Kelley, S Kuhn, J LaMont, J Lange, J Li, B Loggie, B Mahteme, H Mann, G Martin, R Misih, RA Moran, B Morris, D Onate-Ocana, L Petrelli, N Philippe, G Pingpank, J Pitroff, A Piso, P Quinones, M Riley, L Rutstein, L Saha, S Alrawi, S Sardi, A Schneebaum, S Shen, P Shibata, D Spellman, J Stojadinovic, A Stewart, J Torres-Melero, J Tuttle, T Verwaal, V Villar, J Wilkinson, N Younan, R Zeh, H Zoetmulder, F Sebbag, G AF Esquivel, J. Sticca, R. Sugarbaker, P. Levine, E. Yan, T. D. Alexander, R. Baratti, D. Bartlett, D. Barone, R. Barrios, P. Bieligk, S. Bretcha-Boix, P. Chang, C. K. Chu, F. Chu, Q. Daniel, S. deBree, E. Deraco, M. Dominguez-Parra, L. Elias, D. Flynn, R. Foster, J. Garofalo, A. Gilly, F. N. Glehen, O. Gomez-Portilla, A. Gonzalez-Bayon, L. Gonzalez-Moreno, S. Goodman, M. Gushchin, V. Hanna, N. Hartmann, J. Harrison, L. Hoefer, R. Kane, J. Kecmanovic, D. Kelley, S. Kuhn, J. LaMont, J. Lange, J. Li, B. Loggie, B. Mahteme, H. Mann, G. Martin, R. Misih, R. A. Moran, B. Morris, D. Onate-Ocana, L. Petrelli, N. Philippe, G. Pingpank, J. Pitroff, A. Piso, P. Quinones, M. Riley, L. Rutstein, L. Saha, S. Alrawi, S. Sardi, A. Schneebaum, S. Shen, P. Shibata, D. Spellman, J. Stojadinovic, A. Stewart, J. Torres-Melero, J. Tuttle, T. Verwaal, V. Villar, J. Wilkinson, N. Younan, R. Zeh, H. Zoetmulder, F. Sebbag, G. TI Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement (vol 14, pg 128, 2007) SO ANNALS OF SURGICAL ONCOLOGY LA English DT Correction C1 [Esquivel, J.; Pitroff, A.] St Agnes Hosp, Baltimore, MD 21229 USA. [Sticca, R.] Univ N Dakota, Altru Hosp, Grand Forks, ND 58201 USA. [Sugarbaker, P.; Yan, T. D.] Washington Hosp Ctr, Washington, DC 20010 USA. [Levine, E.; Shen, P.; Stewart, J.] Wake Forest Univ, Winston Salem, NC 27109 USA. [Alexander, R.; Hanna, N.] Univ Maryland, Baltimore, MD 21201 USA. [Baratti, D.; Deraco, M.; Younan, R.] Natl Canc Inst, Milan, Italy. [Bartlett, D.; Zeh, H.] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. [Barone, R.] Sharp Healthcare Hosp, San Diego, CA USA. [Barrios, P.] Hosp San Pablo, Barcelona, Spain. [Bieligk, S.; Flynn, R.] Baltimore Washington Med Ctr, Glenn Burnie, MD USA. [Bretcha-Boix, P.] Hosp San Jaime, Torrevieja, Spain. [Chang, C. K.] Walnut Creek Kaiser Permanente, Walnut Creek, CA USA. [Chu, F.; Daniel, S.; Morris, D.] St George Hosp, Sydney, NSW, Australia. [Chu, Q.; Li, B.] Louisiana State Univ, Shreveport, LA 71105 USA. [deBree, E.] Crete Univ Hosp, Sch Med, Iraklion, Greece. [Dominguez-Parra, L.] Inst Nacl Cancerl, Mexico City, DF, Mexico. [Elias, D.] Inst Gustave Roussy, Villejuif, France. [Foster, J.; Loggie, B.] Creighton Univ, Sch Med, Omaha, NE USA. [Garofalo, A.] Osped S Camillo Forlanini, Rome, Italy. [Gilly, F. N.; Glehen, O.] Univ Lyon, Lyon, France. [Gomez-Portilla, A.] Policlin San Jose, Vitoria, Spain. [Gonzalez-Bayon, L.] Hosp Gen Univ Gregorio Maranon, Madrid, Spain. [Gonzalez-Moreno, S.] MD Anderson Espana, Madrid, Spain. [Goodman, M.] Dorothy E Schneider Canc Ctr, San Mateo, CA USA. [Gushchin, V.; Sardi, A.] Mercy Med Ctr, Baltimore, MD USA. [Hartmann, J.] Charite Hosp Campus Mitte, Berlin, Germany. [Harrison, L.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA. [Hoefer, R.] Surg Oncol Associates, Newport News, VA USA. [Kane, J.; Alrawi, S.] Roswell Pk Canc Ctr, Buffalo, NY USA. [Kecmanovic, D.] First Surg Univ Hosp, Belgrade, Serbia. [Kelley, S.; Shibata, D.] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA. [Kuhn, J.; LaMont, J.] Baylor Univ, Med Ctr, Dallas, TX USA. [Mahteme, H.] Akad Univ Hosp, Uppsala, Sweden. [Mann, G.] Univ Washington, Seattle, WA 98195 USA. [Martin, R.] Univ Louisville, Louisville, KY 40292 USA. [Misih, R. A.; Petrelli, N.] Helen F Graham Canc Ctr, Newark, DE USA. [Moran, B.] N Hampshire Hosp, Basingstoke, Hants, England. [Onate-Ocana, L.] Hosp Med Sur, Tlalpan, Mexico. [Lange, J.; Philippe, G.] Surg Dept Kantonsspital, St Gallen, Switzerland. [Pingpank, J.] USA, NCI, Bethesda, MD USA. [Piso, P.] Univ Regensburg, Regensburg, Germany. [Quinones, M.] Dekalb Med Ctr, Decatur, GA USA. [Riley, L.] St Lukes Hosp, Bethlehem, PA USA. [Rutstein, L.] Maine Med Ctr, Portland, ME 04102 USA. [Saha, S.] Miami Valley Hosp, Xenia, OH USA. [Schneebaum, S.] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, IL-69978 Tel Aviv, Israel. [Spellman, J.] Beebe Med Christiana Care, Lewes, DE USA. [Stojadinovic, A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Torres-Melero, J.] Hosp Torrecardenas, Ameria, Spain. [Tuttle, T.] Fairview Univ, Med Ctr, Minneapolis, MN USA. [Verwaal, V.; Zoetmulder, F.] Netherlands Canc Inst, Amsterdam, Netherlands. [Villar, J.] Hosp Virgen de la Nieves, Granada, Spain. [Wilkinson, N.] Univ Iowa, Iowa City, IA USA. [Sebbag, G.] Soroka Univ, Med Ctr, Beer Sheva, Israel. RP Esquivel, J (reprint author), St Agnes Hosp, Baltimore, MD 21229 USA. EM jesusesquivel@yahoo.com RI Baratti, Dario/E-5502-2017 OI Baratti, Dario/0000-0002-5442-2642 NR 1 TC 1 Z9 1 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD DEC PY 2011 VL 18 SU 3 BP S334 EP S335 DI 10.1245/s10434-007-9599-x PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 880HA UT WOS:000299394700096 ER PT J AU Esquivel, J Stojadinovic, A Levine, EA AF Esquivel, Jesus Stojadinovic, Alexander Levine, Edward A. TI The American Society of Peritoneal Surface Malignancies (ASPSM) SO ANNALS OF SURGICAL ONCOLOGY LA English DT Letter C1 [Esquivel, Jesus] St Agnes Hosp, Peritoneal Surface Malignancy Program, Baltimore, MD USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg Oncol, Washington, DC 20307 USA. [Levine, Edward A.] Wake Forest Univ, Dept Surg Oncol, Winston Salem, NC 27109 USA. RP Esquivel, J (reprint author), St Agnes Hosp, Peritoneal Surface Malignancy Program, Baltimore, MD USA. EM jesquive@stagnes.org NR 0 TC 2 Z9 2 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD DEC PY 2011 VL 18 SU 3 BP S218 EP S219 DI 10.1245/s10434-010-1402-8 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 880HA UT WOS:000299394700018 PM 21069469 ER PT J AU Blacksell, SD Jarman, RG Bailey, MS Tanganuchitcharnchai, A Jenjaroen, K Gibbons, RV Paris, DH Premaratna, R de Silva, HJ Lalloo, DG Day, NPJ AF Blacksell, Stuart D. Jarman, Richard G. Bailey, Mark S. Tanganuchitcharnchai, Ampai Jenjaroen, Kemajittra Gibbons, Robert V. Paris, Daniel H. Premaratna, Ranjan de Silva, H. Janaka Lalloo, David G. Day, Nicholas P. J. TI Evaluation of Six Commercial Point-of-Care Tests for Diagnosis of Acute Dengue Infections: the Need for Combining NS1 Antigen and IgM/IgG Antibody Detection To Achieve Acceptable Levels of Accuracy SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; VIRUS-INFECTION; HUMAN SERUM; BLOOD; LAOS AB Six assays were evaluated in this study to determine their suitability for the diagnosis of acute dengue infection using samples from 259 Sri Lankan patients with acute fevers (99 confirmed dengue cases and 160 patients with other confirmed acute febrile illnesses): (i) the Merlin dengue fever IgG & IgM combo device (Merlin), (ii) the Standard Diagnostics Dengue Duo nonstructural 1 (NS1) antigen and IgG/IgM combo device (Standard Diagnostics, South Korea), (iii) the Biosynex Immunoquick dengue fever IgG and IgM (Biosynex, France) assay, (iv) the Bio-Rad NS1 antigen strip (Bio-Rad, France), (v) the Panbio Dengue Duo IgG/IgM Cassette (Inverness, Australia), and (vi) the Panbio dengue NS1 antigen strip (Inverness, Australia). The median number of days of fever prior to admission sample collection was 5 days (interquartile range, 3 to 7 days). Sensitivity and specificity of the NS1 antigen tests ranged from 49 to 59% and from 93 to 99%, respectively, and sensitivity and sensitivity of the IgM antibody test ranged from 71 to 80% and from 46 to 90%, respectively. Combining the NS1 antigen and IgM antibody results from the Standard Diagnostics Dengue Duo test gave the best compromise of sensitivity and specificity (93% and 89%, respectively) and provided the best sensitivity in patients presenting at different times after fever onset. The Merlin IgM/IgG antibody tests correctly classified 64% and 86% of the primary and secondary dengue infection cases, respectively, and the Standard Diagnostics IgM/IgG antibody tests correctly classified 71% and 83% of the primary and secondary dengue infection cases, respectively. This study provides strong evidence of the value of combining dengue antigen-and antibody-based test results in the rapid diagnostic test (RDT) format for the acute diagnosis of dengue. C1 [Blacksell, Stuart D.; Tanganuchitcharnchai, Ampai; Jenjaroen, Kemajittra; Paris, Daniel H.; Day, Nicholas P. J.] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit MORU, Bangkok 10400, Thailand. [Blacksell, Stuart D.; Paris, Daniel H.; Day, Nicholas P. J.] Univ Oxford, Churchill Hosp, Ctr Trop Med, Oxford OX3 7LJ, England. [Jarman, Richard G.; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Bailey, Mark S.] Royal Ctr Def Med, Dept Mil Med, Birmingham B15 2SQ, England. [Premaratna, Ranjan; de Silva, H. Janaka] Univ Kelaniya, Dept Med, Fac Med, Ragama, Sri Lanka. [Lalloo, David G.] Univ Liverpool Liverpool Sch Trop Med, Clin Res Grp, Liverpool L3 5QA, Merseyside, England. RP Blacksell, SD (reprint author), Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit MORU, 420-6 Rajvithi Rd, Bangkok 10400, Thailand. EM stuart@tropmedres.ac RI Bailey, Mark/D-3854-2013; OI Bailey, Mark/0000-0003-4840-5093; Blacksell, Stuart/0000-0001-6576-726X FU United Kingdom Defence Postgraduate Medical Deanery; University of Kelaniya; Wellcome Trust of Great Britain FX This study was funded by grants from the United Kingdom Defence Postgraduate Medical Deanery, the University of Kelaniya, and the Wellcome Trust of Great Britain. NR 15 TC 55 Z9 57 U1 4 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD DEC PY 2011 VL 18 IS 12 BP 2095 EP 2101 DI 10.1128/CVI.05285-11 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 863CX UT WOS:000298141500013 PM 22012979 ER PT J AU Liu, LB Liu, ZJ Barrowes, BE AF Liu, Lanbo Liu, Zijian Barrowes, Benjamin E. TI Through-Wall Bio-Radiolocation With UWB Impulse Radar: Observation, Simulation and Signal Extraction SO IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING LA English DT Article DE Biomedical signal processing; finite difference methods; ground penetrating radar; ultra wideband antennas AB In this paper the cardio-respiratory signatures of human beings were studied using both an ultra-wide band (UWB) impulse radar system in a laboratory through-wall experiment and a numerical simulation using the finite difference time domain (FDTD) method. Signals from both the physical experiment and numerical simulation are processed with the Hilbert-Huang Transform (HHT), a novel signal processing approach for nonlinear and non-stationary data analysis. The results show that by using the HHT, human respiration characteristics can be successfully identified and differentiated for different subjects and a variety of respiratory statuses. However, reliable detection of cardiologic signatures requires a radar system with higher central frequency. Our results demonstrate that this combination of UWB impulse radar and HHT data processing has potential for through-wall life detection and possibly other applications. C1 [Liu, Lanbo] Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. [Liu, Zijian] Univ Connecticut, Biomed Engn Program, Storrs, CT 06269 USA. [Barrowes, Benjamin E.] USA, Corps Engn Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Liu, LB (reprint author), Univ Connecticut, Dept Civil & Environm Engn, Storrs, CT 06269 USA. EM lanbo@engr.uconn.edu; zijian.liu@huskymail.uconn.edu; ben-jamin.e.barrowes@usace.army.mil FU U.S. Department of Defense [W913E5-07-C-008] FX This work was supported in part by the U.S. Department of Defense under Grant W913E5-07-C-008. NR 17 TC 35 Z9 35 U1 4 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1939-1404 J9 IEEE J-STARS JI IEEE J. Sel. Top. Appl. Earth Observ. Remote Sens. PD DEC PY 2011 VL 4 IS 4 BP 791 EP 798 DI 10.1109/JSTARS.2011.2157461 PG 8 WC Engineering, Electrical & Electronic; Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Engineering; Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA 861XR UT WOS:000298054500008 ER PT J AU Perkins, MW Pierre, Z Rezk, P Song, J Oguntayo, S Morthole, V Sciuto, AM Doctor, BP Nambiar, MP AF Perkins, Michael W. Pierre, Zdenka Rezk, Peter Song, Jian Oguntayo, Samuel Morthole, Venee Sciuto, Alfred M. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Protective Effects of Aerosolized Scopolamine Against Soman-Induced Acute Respiratory Toxicity in Guinea Pigs SO INTERNATIONAL JOURNAL OF TOXICOLOGY LA English DT Article DE chemical warfare nerve agents; cholinesterases; inhalation exposure; nasal therapeutic agents; pulmonary toxicity ID NERVE AGENT-VX; NONNEURONAL CHOLINERGIC SYSTEM; INHALATION EXPOSURE; INDUCED SEIZURES; TISSUE CHOLINESTERASE; BRAIN-DAMAGE; ACETYLCHOLINESTERASE; ATROPINE; EFFICACY; PYRIDOSTIGMINE AB The protective efficacy of the antimuscarinic agent scopolamine was evaluated against soman (o-pinacolyl methylphosphonofluoridate [GD])-induced respiratory toxicity in guinea pigs. Anesthetized animals were exposed to GD (841 mg/m(3)) by microinstillation inhalation exposure and treated 30 seconds later with endotracheally aerosolized scopolamine (0.25 mg/kg) and allowed to recover for 24 hours. Treatment with scopolamine significantly increased survival and reduced clinical signs of toxicity and body weight loss in GD-exposed animals. Analysis of bronchoalveolar lavage (BAL) fluid showed normalization of GD-induced increased cell death, total cell count, and protein following scopolamine treatment. The BAL fluid acetylcholinesterase and butyrylcholinesterase levels were also increased by scopolamine treatment. Respiratory dynamics parameters were normalized at 4 and 24 hours post-GD exposure in scopolamine-treated animals. Lung histology showed that scopolamine treatment reduced bronchial epithelial and subepithelial inflammation and multifocal alveolar septal edema. These results suggest that aerosolized scopolamine considerably protects against GD-induced respiratory toxicity. C1 [Song, Jian; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, Silver Spring, MD 20910 USA. [Perkins, Michael W.; Pierre, Zdenka; Rezk, Peter; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Morthole, Venee] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Blast Induced Neurotrauma Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@amedd.army.mil FU Defense Threat Reduction Agency [3.F0006_08_WR_C] FX The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: Defense Threat Reduction Agency, proposal #3.F0006_08_WR_C. NR 70 TC 4 Z9 4 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1091-5818 J9 INT J TOXICOL JI Int. J. Toxicol. PD DEC PY 2011 VL 30 IS 6 BP 639 EP 649 DI 10.1177/1091581811415874 PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 873LL UT WOS:000298884700004 PM 21960666 ER PT J AU McLean, RC Nazarian, SM Gluckman, TJ Schulman, SP Thiemann, DR Shapiro, EP Conte, JV Thompson, JB Shafique, I McNicholas, KW Villines, TC Laws, KM Rade, JJ AF McLean, R. C. Nazarian, S. M. Gluckman, T. J. Schulman, S. P. Thiemann, D. R. Shapiro, E. P. Conte, J. V. Thompson, J. B. Shafique, I. McNicholas, K. W. Villines, T. C. Laws, K. M. Rade, J. J. TI Relative importance of patient, procedural and anatomic risk factors for early vein graft thrombosis after coronary artery bypass graft surgery SO JOURNAL OF CARDIOVASCULAR SURGERY LA English DT Article DE Saphenous vein; Thrombosis; Coronary artery bypass; Angiography ID ANGIOGRAPHIC FOLLOW-UP; OFF-PUMP; PATENCY; FLOW; TRIAL; PREVENTION; OCCLUSION; OUTCOMES; FAILURE AB Aim. The aim of the present study was to investigate the relative importance of a wide array of patient demographic, procedural, anatomic and perioperative variables as potential risk factors for early saphenous vein graft (SVG) thrombosis after coronary artery bypass graft (CABG) surgery. Methods. The patency of 611 SVGs in 291 patients operated on at four different hospitals enrolled in the Reduction in Graft Occlusion Rates (RIGOR) study was assessed six months after CABG surgery by multi-detector computed tomography coronary angiography or clinically-indicated coronary angiography. The odds of graft occlusion versus patency were analyzed using multilevel multivariate logistic regression with clustering on patient. Results. SVG failure within six months of CABG surgery was predominantly an all-or-none phenomenon with 126 (20.1%) SVGs totally occluded, 485 (77.3%) widely patent and only 16 (2.5%) containing high-grade stenoses. Target vessel diameter <= 1.5 mm (adjusted OR 2.37, P=0.003) and female gender (adjusted OR 2.46, P=0.01) were strongly associated with early SVG occlusion. In a subgroup analysis of 354 SVGs in which intraoperative graft blood flow was measured, lower mean flow was also significantly associated with SVG occlusion when analyzed as a continuous variable (adjusted OR 0.984, P=0.006) though not when analyzed dichotomously, <40 mL/min versus >= 40 mL/min (adjusted OR 1.86, P=0.08). Conclusion. Small target vessel diameter, female gender and low mean graft blood flow are significant risk factors for SVG thrombosis within six months of CABG surgery in patients on postoperative aspirin therapy. This information may be useful in guiding revascularization strategies in selected patients. C1 [McLean, R. C.; Nazarian, S. M.; Gluckman, T. J.; Schulman, S. P.; Thiemann, D. R.; Shapiro, E. P.; Conte, J. V.; Thompson, J. B.; Shafique, I.; Laws, K. M.; Rade, J. J.] Johns Hopkins Sch Med, Baltimore, MD USA. [McNicholas, K. W.] Christiana Res Inst, Christiana, DE USA. [Villines, T. C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Rade, JJ (reprint author), Univ Massachusetts, Sch Med, Div Cardiol, 55 Lake Ave N, Worcester, MA 01605 USA. EM jjeffrey.rade@umassmed.edu FU Johns Hopkins Institute for Clinical and Translational Research; National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA [UL1 RR025005]; Flight Attendant Medical Research Foundation, Miami, HA, USA FX This study was supported by the Johns Hopkins Institute for Clinical and Translational Research (funded by UL1 RR025005 from the National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA), The Medicines Company, Parsippany, NI and a grant front the Flight Attendant Medical Research Foundation, Miami, HA, USA (to JJR). NR 29 TC 13 Z9 14 U1 0 U2 0 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0021-9509 J9 J CARDIOVASC SURG JI J. Cardiovasc. Surg. PD DEC PY 2011 VL 52 IS 6 BP 877 EP 885 PG 9 WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease SC Cardiovascular System & Cardiology; Surgery GA 862FQ UT WOS:000298075600014 PM 22051997 ER PT J AU Gallaway, MS Millikan, AM Bell, MR AF Gallaway, M. Shayne Millikan, Amy M. Bell, Michael R. TI The Association Between Deployment-Related Posttraumatic Growth Among US Army Soldiers and Negative Behavioral Health Conditions SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article DE Behavioral health; Combat; Deployment; Military; Posttraumatic growth; Resilience ID COMBAT EXPOSURE; STRESS-DISORDER; AFGHANISTAN; INVENTORY; SYMPTOMS; ASSAULT; LIFE; IRAQ; WAR AB Objectives: This study assessed posttraumatic growth (PTG) in a sample of U. S. Army Soldiers using the Post-Traumatic Growth Inventory (PTGI), and the relationship between PTG and negative behavioral health (BH) conditions. Design: A sample of Soldiers with prior combat deployment experience (n=1,834) completed an anonymous survey including demographics, the PTGI, and negative BH conditions. Results: Among previously deployed Soldiers, those reporting the highest number of combat experiences also reported significantly higher overall PTG. A significant inverse relationship was observed between PTG and recent suicidal ideation, whereby Soldiers reporting recent suicidal ideation reported significantly lower overall PTG. Conclusions: This study quantified PTG resulting from deployment and demonstrated the degree to which combat experiences might result in PTG. (C) 2011 Wiley Periodicals, Inc. J Clin Psychol 67: 1151-1160, 2011. C1 [Gallaway, M. Shayne; Millikan, Amy M.] USA, Inst Publ Hlth, Washington, DC USA. [Bell, Michael R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Gallaway, MS (reprint author), 5158 Blackhawk Rd, Apg Ea, MD 21010 USA. EM Shayne.Gallaway@us.army.mil NR 34 TC 11 Z9 12 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD DEC PY 2011 VL 67 IS 12 BP 1151 EP 1160 DI 10.1002/jclp.20837 PG 10 WC Psychology, Clinical SC Psychology GA 855PJ UT WOS:000297576400001 PM 22042556 ER PT J AU Wright, KM Britt, TW Bliese, PD Adler, AB Picchioni, D Moore, D AF Wright, Kathleen M. Britt, Thomas W. Bliese, Paul D. Adler, Amy B. Picchioni, Dante Moore, DeWayne TI Insomnia as Predictor Versus Outcome of PTSD and Depression Among Iraq Combat Veterans SO JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article DE insomnia; posttraumatic stress disorder; longitudinal; combat exposure; postdeployment mental health ID POSTTRAUMATIC-STRESS-DISORDER; COVARIANCE STRUCTURE-ANALYSIS; TRAUMATIC BRAIN-INJURY; SLEEP-DEPRIVATION; PSYCHIATRIC-DISORDERS; TEST STATISTICS; WAR VETERANS; PRIMARY-CARE; ACTIVE-DUTY; DISTURBANCE AB Objectives: The study conducted a longitudinal assessment of insomnia as an antecedent versus consequence of posttraumatic stress disorder (PTSD) and depression symptoms among combat veterans. Design: Two postdeployment time points were used in combination with structural equation modeling to examine the relative strength of two possible directions of prediction: insomnia as a predictor of psychological symptoms, and psychological symptoms as a predictor of insomnia. Participants were active duty soldiers (N = 659) in a brigade combat team who were assessed 4 months after their return from a 12-month deployment to Iraq, and then again eight months later. Results: Although both insomnia and psychological symptoms were associated at both time periods and across time periods, insomnia at 4 months postdeployment was a significant predictor of change in depression and PTSD symptoms at 12 months postdeployment, whereas depression and PTSD symptoms at 4 months postdeployment were not significant predictors of change in insomnia at 12 months postdeployment. Conclusions: Results support the role of insomnia in the development of additional psychological problems and highlight the clinical implications for combat veterans, to include the importance of longitudinal assessment and monitoring of sleep disturbances, and the need for early intervention. (C) 2011 Wiley Periodicals, Inc. J Clin Psychol 67: 1240-1258, 2011. C1 [Wright, Kathleen M.; Britt, Thomas W.; Adler, Amy B.] USA, Med Res Unit Europe, Walter Reed Army Inst Res, Heidelberg, Germany. [Bliese, Paul D.; Picchioni, Dante] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. [Britt, Thomas W.] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA. RP Wright, KM (reprint author), USA, Med Res Unit, APO, AE 09042 USA. EM kathleen.wright@us.army.mil; twbritt@clemson.edu RI Schueter, nicos/A-3625-2014 NR 74 TC 56 Z9 56 U1 3 U2 14 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-9762 J9 J CLIN PSYCHOL JI J. Clin. Psychol. PD DEC PY 2011 VL 67 IS 12 BP 1240 EP 1258 DI 10.1002/jclp.20845 PG 19 WC Psychology, Clinical SC Psychology GA 855PJ UT WOS:000297576400008 PM 22065464 ER PT J AU Chao, NH Cordes, JA Carlucci, D DeAngelis, ME Lee, J AF Chao, N. H. Cordes, J. A. Carlucci, D. DeAngelis, M. E. Lee, Jyeching TI The Use of Potting Materials for Electronic-Packaging Survivability in Smart Munitions SO JOURNAL OF ELECTRONIC PACKAGING LA English DT Article AB Potted electronics are becoming more common in precision-guided artillery due to demands for increased structural-robustness. In field artillery applications, the potted electronics are inactive for most of their lifetime. Projectiles may be stored in a bunker without environmental (temperature and humidity) controls for up to 20 years. In contrast, the electronics for most commercial applications tend to be active for most of their lifetime and the operating environment is more predictable. This difference makes the thermal management task for the artillery application challenging. The ability to accurately analyze these designs requires the use of fully coupled thermal-stress transient-analysis with accurate material properties over the full temperature range. To highlight the thermal-stress transient effects, the potted configuration of a typical electronics assembly is analyzed. The thermal analysis indicates that significant stresses can develop in critical locations as a result of temperature cycles. The structural dynamic responses of unpotted and potted assemblies, subjected to gun-launch environments, are also compared. The results indicate that for the potted design, the dynamic response of the processor board is attenuated by the potting material. [DOI: 10.1115/1.4005375] C1 [Chao, N. H.; Cordes, J. A.; Carlucci, D.; DeAngelis, M. E.; Lee, Jyeching] USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Chao, NH (reprint author), USA, ARDEC, Picatinny Arsenal, NJ 07806 USA. FU Kyocera U.S. FX The authors would like to thank the Kyocera U.S. support team, Jake Morikami, Trey Price, and Kazuhito Kanazashi, for the information they provided. NR 17 TC 3 Z9 4 U1 1 U2 10 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1043-7398 J9 J ELECTRON PACKAGING JI J. Electron. Packag. PD DEC PY 2011 VL 133 IS 4 AR 041003 DI 10.1115/1.4005375 PG 10 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA 868QE UT WOS:000298537000003 ER PT J AU Wan, CY Cheng, LJ Quon, CG Li, Y AF Wan, Cheuk Y. Cheng, Lijuan Quon, Christopher G. Li, Yang TI Compressive Behavior of Concrete Confined by Mechanism-Based Fiber Composite Bistable Structure SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Concrete columns; Compression; Confinement; Fiber-reinforced polymer; Rehabilitation ID REINFORCED POLYMER; ENERGY-ABSORPTION; DESIGN GUIDELINES; FRP; DUCTILITY; COLUMNS; TENSION AB The application of fiber-reinforced polymer (FRP) composites in civil engineering has advanced drastically in recent years, especially in the retrofit of concrete bridge columns. However, composite's typical nonductile behavior and low-energy absorption are some of the concerns that have yet to be fully addressed. The objective of this research is to investigate a new mechanism-based bistable composite structure as the wrapping system for concrete columns to improve the energy absorption and damage tolerance. The bistable structure consists of energy-absorbing main links (primary load carrier) and waiting links (secondary load carrier to be activated after main link fails). A series of uniaxial compression tests on cylindrical concrete members wrapped with hybrid carbon-glass FRP bistable structure were conducted to demonstrate the concept and study the effect caused by link geometry. The results showed that a controlled failure with signs of failure (warning) was achieved in the system and both the ductility and energy absorption were enhanced. The effectiveness of the confinement depended on the number of links and the energy absorption relied on the size of the links. DOI: 10.1061/(ASCE)MT.1943-5533.0000329. (C) 2011 American Society of Civil Engineers. C1 [Cheng, Lijuan; Quon, Christopher G.] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Wan, Cheuk Y.] USA, Corps Engineers, Sacramento, CA 95814 USA. [Li, Yang] Tongji Univ, Dept Bridge Engn, Shanghai 200092, Peoples R China. RP Cheng, LJ (reprint author), Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. EM andy.cheuk.wan@gmail.com; dawcheng@ucdavis.edu; cgquon@ucdavis.edu; 8ly@tongji.edu.cn FU Hellman Foundation Board FX This research is partially funded by the Hellman Foundation Board (2008-2009 UC Davis Hellman Fellows). Their financial support is gratefully acknowledged. NR 26 TC 3 Z9 3 U1 0 U2 7 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD DEC PY 2011 VL 23 IS 12 BP 1755 EP 1759 DI 10.1061/(ASCE)MT.1943-5533.0000329 PG 5 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 876UV UT WOS:000299134100022 ER PT J AU Yanovich, R Merkel, D Israeli, E Evans, RK Erlich, T Moran, DS AF Yanovich, Ran Merkel, Drorit Israeli, Eran Evans, Rachel K. Erlich, Tomer Moran, Daniel S. TI ANEMIA, IRON DEFICIENCY, AND STRESS FRACTURES IN FEMALE COMBATANTS DURING 16 MONTHS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE military performance; bone stress; nutrition; military basic training ID MILITARY RECRUITS; INFANTRY RECRUITS; PHYSICAL-FITNESS; BONE-FORMATION; WOMEN; PREVALENCE; NUTRITION; ARMY; RATS; METABOLISM AB Yanovich, R, Merkel, D, Israeli, E, Evans, RK, Erlich, T, and Moran, DS. Anemia, iron deficiency, and stress fractures in female combatants during 16 months. J Strength Cond Res 25(12): 3412-3421, 2011-The purpose of this study is to evaluate the hematological profile of military recruits in different settings and training programs and to investigate the link between anemia and iron deficiency with stress fracture (SF) occurrence. We surveyed 3 groups of recruits for 16 months: 221 women (F) and 78 men (M) from 3 different platoons of a gender-integrated combat battalion and a control group (C(F)) of 121 female soldiers from a noncombat unit. Data were fully collected upon induction and at 4 and 16 months from 48F, 21M, and 31C(F). Blood tests, anthropometry, physical aerobic fitness, and SF occurrence were evaluated. On induction day, 18.0 and 19.0% of F and C(F) were found to be anemic, and 61.4 and 50.9%, respectively, were found to have iron deficiency, whereas 7.7% of M were found to be anemic and 10.2% iron deficient. During the 4 months of army basic training (ABT), anemia and iron deficiency prevalence did not change significantly in any group. After 16-months, anemia prevalence decreased by 8% among F and C(F) and abated in M. Iron deficiency was prevalent in 50.0, 59.4, and 18.8% of F, C(F), and M, respectively. Stress fractures were diagnosed in 14 F during ABT, and they had a significantly higher prevalence (p < 0.05) of anemia and iron deficiency anemia compared to F without SFs. The observed link between anemia and iron deficiency on recruitment day and SFs suggests the importance of screening female combat recruits for these deficiencies. To minimize the health impact of army service on female soldiers, preventative measures related to anemia and iron deficiency should be administered. Further research is needed for evaluating the influence of low iron in kosher meat as a possible explanation for the high prevalence of iron deficiency among young Israeli recruits. C1 [Yanovich, Ran; Erlich, Tomer; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Merkel, Drorit] Chaim Sheba Med Ctr, Div Hematol, Hematol & Bone Marrow Transplantat Dept, IL-52621 Tel Hashomer, Israel. [Israeli, Eran] Hebrew Univ Jerusalem, Hadassah Med Ctr, Div Med, Dept Gastroenterol, Jerusalem, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Moran, Daniel S.] Ariel Univ, Ctr Samaria, Sch Hlth Sci, Ariel, Israel. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il FU Medical Research and Material Command [W911QY-06-P0085] FX The study was supported in part by a contract from the Medical Research and Material Command (no. W911QY-06-P0085). The opinions or assertions contained herein are the private views of the authors and should not be construed as official or reflecting the views of the US Department of Defence or the Israel Defence Forces. The authors have no conflict of interest to disclose. The results of this study do not constitute endorsement by the National Strength and Conditioning Association. NR 35 TC 5 Z9 5 U1 1 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD DEC PY 2011 VL 25 IS 12 BP 3412 EP 3421 DI 10.1519/JSC.0b013e318215f779 PG 10 WC Sport Sciences SC Sport Sciences GA 860ZE UT WOS:000297987000025 PM 22080308 ER PT J AU Vecherin, SN Wilson, DK Ostashev, VE AF Vecherin, Sergey N. Wilson, D. Keith Ostashev, Vladimir E. TI Incorporating source directionality into outdoor sound propagation calculations SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID PE MODEL; ATMOSPHERE AB Many outdoor sound sources, such as aircraft or ground vehicles, exhibit directional radiation patterns. However, long-range sound propagation algorithms are usually formulated for omnidirectional point sources. This paper describes two methods for incorporating directional sources into long-range sound propagation algorithms. The first is the equivalent source method (ESM), which determines a compact distribution of omnidirectional point sources reproducing a given directivity pattern in the far field. This Method can be used with any propagation algorithm because it explicitly reconstructs a source function as a set of point sources with certain amplitudes and positions. The second is a directional starter method (DSM), which is developed specifically for the parabolic equation (PE) algorithms. This method derives narrow- or wide-angle directional starter fields, corresponding to a given source directivity pattern, without reconstructing the equivalent source distribution. Although the ESM can also be used for the PE, the DSM is simpler and can be more convenient, especially if the sound propagation is calculated only for one or a few azimuthal directions. While these two methods are found to produce generally distinct starter fields, they nonetheless yield identical directivity patterns. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3655881] C1 [Vecherin, Sergey N.; Wilson, D. Keith; Ostashev, Vladimir E.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ostashev, Vladimir E.] Univ Colorado, Cooperat Inst Res Environm Sci, Boulder, CO 80305 USA. RP Vecherin, SN (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sergey.N.Vecherin@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 FU Engineer Research and Development Center (ERDC) Geospatial Research and Engineering FX Funding for this work was provided by the Engineer Research and Development Center (ERDC) Geospatial Research and Engineering business area. Dr. Vecherin's work was performed during an appointment to the Postgraduate Research Participation Program at the U.S. Army Cold Regions Research and Engineering Laboratory (CRREL) administrated by the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the U.S. Department of Energy and CRREL. NR 29 TC 7 Z9 7 U1 0 U2 5 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD DEC PY 2011 VL 130 IS 6 BP 3608 EP 3622 DI 10.1121/1.3655881 PG 15 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 869AX UT WOS:000298569100018 PM 22225018 ER PT J AU Silverman, AL AF Silverman, Adam L. TI The De-Radicalization of Jihadis: Transforming Armed Islamist Movements SO POLITICS AND RELIGION LA English DT Book Review C1 [Silverman, Adam L.] USA, War Coll, Washington, DC 20310 USA. RP Silverman, AL (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 2 U2 5 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 1755-0483 J9 POLIT RELIG JI Polit. Relig. PD DEC PY 2011 VL 4 IS 3 BP 591 EP 594 DI 10.1017/S1755048311000526 PG 5 WC Political Science; Religion SC Government & Law; Religion GA 878BN UT WOS:000299226600013 ER PT J AU Pandolf, KB Francesconi, R Sawka, MN Cymerman, A Hoyt, RW Young, AJ Zambraski, EJ AF Pandolf, Kent B. Francesconi, Ralph Sawka, Michael N. Cymerman, Allen Hoyt, Reed W. Young, Andrew J. Zambraski, Edward J. TI United States Army Research Institute of Environmental Medicine: Warfighter research focusing on the past 25 years SO ADVANCES IN PHYSIOLOGY EDUCATION LA English DT Editorial Material DE biomedical modeling; environmental physiology; military clothing; military nutrition; military performance AB Pandolf KB, Francesconi R, Sawka MN, Cymerman A, Hoyt RW, Young AJ, Zambraski EJ. United States Army Research Institute of Environmental Medicine: Warfighter research focusing on the past 25 years. Adv Physiol Educ 35: 353-360, 2011; doi:10.1152/advan.00049.2011.-The United States Army Research Institute of Environmental Medicine (USARIEM) celebrated its 50th anniversary on July 1, 2011. This article reviews its history, evolution, and transition of its research programs as well as its scientific and military accomplishments, emphasizing the past 25 yr. During the 1990s, USARIEM published a series of pocket guides providing guidance for sustaining Warfighter health and performance in Southwest Asia, Somalia, the former Republic of Yugoslavia, Rwanda, and Haiti. Issues identified during Operation Desert Storm elicited research that improved nutritional guidelines for protracted desert operations; safer use of nuclear, chemical, and biological protective clothing; equipment, development, and fielding of efficient microclimate cooling systems; and effective evaluation of pharmaceuticals to protect soldiers from chemical and biological threats. During the first decade of the 21st century, USARIEM and the Department of the Army published official medical/performance doctrines for operations in the heat and cold and at high altitude. The current Global War on Terrorism focused research to improve doctrines for hot, cold, and high-altitude operations, reduce musculoskeletal training injuries, provide improved field nutrition, more efficient planning for operational water requirements, and improve both military clothing and materiel. This article also describes the critically important interactions and communications between USARIEM and deployed units and the benefits to Warfighters from this association. This report presents USARIEM's unique and world-class facilities, organizational changes, scientific and support personnel, and major research accomplishments, including the publication of 2,200 scientific papers over the past 25 yr. C1 [Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Sawka, MN (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, 15 Kansas St,Bldg 42, Natick, MA 01760 USA. EM michael.sawka@us.army.mil NR 10 TC 0 Z9 0 U1 1 U2 8 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1043-4046 J9 ADV PHYSIOL EDUC JI Adv. Physiol. Educ. PD DEC PY 2011 VL 35 IS 4 BP 353 EP 360 DI 10.1152/advan.00049.2011 PG 8 WC Education, Scientific Disciplines; Physiology SC Education & Educational Research; Physiology GA 863GR UT WOS:000298151300006 PM 22139770 ER PT J AU Cord, MT Surr, RK Walden, BE Dittberner, AB AF Cord, Mary T. Surr, Rauna K. Walden, Brian E. Dittberner, Andrew B. TI Ear Asymmetries and Asymmetric Directional Microphone Hearing Aid Fittings SO AMERICAN JOURNAL OF AUDIOLOGY LA English DT Article DE hearing aids; directional microphones; speech recognition; ease of listening ID NOISE AB Purpose: To determine whether an asymmetry between ears for speech understanding in noise was related to performance with, or preference for, 1 of 2 asymmetric microphone fittings in which omnidirectional processing was provided to 1 ear and directional processing to the other. Method: Twenty-eight adults with symmetric sensorineural hearing impairment were recruited from the clinic population. Sixteen individuals had symmetric hearing-in-noise ability between their right and left ears, and 12 participants had an asymmetry for speech understanding in noise between ears. A repeated measures design was used. Interactions between various microphone fittings and speech signal locations in noise were assessed in the laboratory. In addition, the listeners with asymmetry between ears for hearing in noise completed a field trial comparing the 2 fittings in everyday listening situations. Results: Laboratory testing resulted in different patterns of performance for the 2 groups. Field trial results revealed that participants generally noticed little difference between the 2 fittings in everyday life and did not express a strong preference for 1 fitting over the other. Conclusion: An asymmetry between ears for speech understanding in noise did not result in preference for 1 asymmetric fitting over the other in everyday listening situations. C1 [Cord, Mary T.; Surr, Rauna K.; Walden, Brian E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Dittberner, Andrew B.] GN ReSound Grp, Chicago, IL USA. RP Cord, MT (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM mary.cord@med.navy.mil FU GN ReSound Hearing Care, Chicago, IL; Clinical Investigation Regulatory Office, U.S. Army Medical Department, Fort Sam Houston, TX FX This work was sponsored by GN ReSound Hearing Care, Chicago, IL, through a Cooperative Research and Development Agreement with the Clinical Investigation Regulatory Office, U.S. Army Medical Department, Fort Sam Houston, TX. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Army, Department of Defense, the U. S. government, or GN ReSound. We certify that all individuals who qualify as authors have been listed; each has participated in the conception and design of this work, the analysis of data, the writing of the document, and the approval of the submission of this version; that the document represents valid work; that if we used information derived from another source, we obtained all necessary approvals to use it and made appropriate acknowledgements in the document; and that each takes public responsibility for it. Nothing in the article implies any endorsement by the federal government, the Department of Defense, or the Department of the Army. We acknowledge that Research Protocol No. 0525023, "Implications of SNR Hearing Loss for Asymmetric Hearing Aid Microphone Fittings," received applicable Walter Reed Army Medical Center institutional review board review and approval. NR 25 TC 3 Z9 3 U1 0 U2 2 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE, ROCKVILLE, MD 20852-3279 USA SN 1059-0889 J9 AM J AUDIOL JI Am. J. Audiol. PD DEC PY 2011 VL 20 IS 2 BP 111 EP 122 DI 10.1044/1059-0889(2011/10-0035) PG 12 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 865ZJ UT WOS:000298349100005 PM 21764997 ER PT J AU Yoshiya, K Lapchak, PH Thai, TH Kannan, L Rani, P Lucca, JJD Tsokos, GC AF Yoshiya, Kazuhisa Lapchak, Peter H. Thai, To-Ha Kannan, Lakshmi Rani, Poonam Lucca, Jurandir J. Dalle Tsokos, George C. TI Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY LA English DT Article DE intestine; immunoglobulin A; immunoglobulin M; complement ID ISCHEMIA-REPERFUSION INJURY; TOLL-LIKE RECEPTORS; INFLAMMATORY RESPONSES; NATURAL ANTIBODIES; IMMUNE-SYSTEM; TISSUE-INJURY; MESENTERIC ISCHEMIA/REPERFUSION; INNATE IMMUNITY; ORGAN INJURY; LUNG INJURY AB Yoshiya K, Lapchak PH, Thai T-H, Kannan L, Rani P, Lucca JJ, Tsokos GC. Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury. Am J Physiol Gastrointest Liver Physiol 301: G1020-G1030, 2011. First published September 8, 2011; doi:10.1152/ajpgi.00239.2011.-Gut commensal bacteria play important roles in the development and homeostasis of intestinal immunity. However, the role of gut commensals in intestinal ischemia/reperfusion (I/R) injury is unclear. To determine the roles of gut commensal bacteria in intestinal IR injury, we depleted gut microbiota with a broad-spectrum antibiotic cocktail and performed mesenteric I/R (M I/R). First, we confirmed that antibiotic treatment completely depleted gut commensal bacteria and diminished the size of secondary lymphoid tissues such as the Peyer's patches. We next found that antibiotic treatment attenuated intestinal injury following M I/R. Depletion of gut commensal bacteria reduced the expression of Toll-like receptor (TLR)2 and TLR4 in the intestine. Both are well-known receptors for gram-positive and -negative bacteria. Decreased expression of TLR2 and TLR4 led to the reduction of inflammatory mediators, such as TNF, IL-6, and cyclooxygenase-2. Intestinal I/R injury is initiated when natural antibodies recognize neo-antigens that are revealed on ischemic cells and activate the complement pathway. Thus we evaluated complement and immunoglobulin (Ig) deposition in the damaged intestine and found that antibiotic treatment decreased the deposition of both C3 and IgM. Interestingly, we also found that the deposition of IgA also increased in the intestine following M I/R compared with control mice and that antibiotic treatment decreased the deposition of IgA in the damaged intestine. These results suggest that depletion of gut commensal bacteria decreases B cells, Igs, and TLR expression in the intestine, inhibits complement activation, and attenuates intestinal inflammation and injury following M I/R. C1 [Yoshiya, Kazuhisa; Lapchak, Peter H.; Thai, To-Ha; Kannan, Lakshmi; Rani, Poonam; Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. [Lucca, Jurandir J. Dalle] USA, Inst Surg Res, San Antonio, TX USA. RP Tsokos, GC (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, 330 Brookline Ave,CLS 928, Boston, MA 02115 USA. EM gtsokos@bidmc.harvard.edu RI Ji, Haofeng/G-6206-2012; OI Lapchak, Peter/0000-0001-8597-088X FU Medical Research and Material Command of the Department of the Army [W81XWH-09-1-0530] FX This work was supported by Grant W81XWH-09-1-0530 from Medical Research and Material Command of the Department of the Army. NR 72 TC 34 Z9 36 U1 0 U2 15 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0193-1857 J9 AM J PHYSIOL-GASTR L JI Am. J. Physiol.-Gastroint. Liver Physiol. PD DEC PY 2011 VL 301 IS 6 BP G1020 EP G1030 DI 10.1152/ajpgi.00239.2011 PG 11 WC Gastroenterology & Hepatology; Physiology SC Gastroenterology & Hepatology; Physiology GA 866HA UT WOS:000298369900009 PM 21903760 ER PT J AU Eyase, FL Akala, HM Johnson, JD Walsh, DS AF Eyase, Fredrick L. Akala, Hoseah M. Johnson, Jacob D. Walsh, Douglas S. TI Inhibitory Activity of Ferroquine versus Chloroquine against Plasmodium falciparum Field Isolates from Western Kenya Determined by Using a SYBR Green I In Vitro Assay SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIMALARIAL-DRUG; DIHYDROFOLATE-REDUCTASE; ORGANOMETALLIC ANALOG; RESISTANT MALARIA; SUSCEPTIBILITY; MUTATIONS; MECHANISM; PARASITES; BORDER; GENES AB Ferroquine (FQ), a chloroquine (CQ) analog, is being developed to treat persons with Plasmodium falciparum malaria. In 146 P falciparum field isolates from western Kenya, we measured 50% inhibitory concentrations (IC(50); nM) of CQ and FQ by a SYBR Green Tin vitro assay. Reference clones included W2 (CQ resistant) and D6 (CQ sensitive). Mutation analysis was done for P falciparum CQ-resistance transporter gene (Pfcrt K76T). Median IC(50) values for FQ were lower than CQ for field isolates and the W2 clone (both P < 0.05). The Pfcrt mutation (76T), which was detected in > 80% of isolates, conferred higher CQ IC(50) values (P < 0.05) and modestly lower FQ IC(50) values (P < 0.05), versus Pfcrt wild type (K76). FQ is more potent than CQ against CO-resistant P falciparum field isolates and the W2 clone, and is less affected by Pfcrt 76T. These findings support the notion that FQ could be useful in treating persons with P falciparum malaria. C1 [Walsh, Douglas S.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, US Army Med Component, Bangkok 10400, Thailand. [Eyase, Fredrick L.; Akala, Hoseah M.; Johnson, Jacob D.] Kenya Med Res Inst Walter Reed Project, Dept Emerging Infect Dis Program, US Army Med Res Unit Kenya, Kisumu 40100, Kenya. Kenya Med Res Inst Walter Reed Project, Dept Emerging Infect Dis Program, US Army Med Res Unit Kenya, Nairobi 40100, Kenya. RP Walsh, DS (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, US Army Med Component, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM feyase@wrp-ksm.org; hakala@wrp-ksm.org; jjohnson@wrp-ksm.org; douglas.walsh@afrims.org RI Valle, Ruben/A-7512-2013 FU U.S. Department of Emerging Infectious Diseases (Silver Spring, MD) FX This study was supported by the U.S. Department of Emerging Infectious Diseases Program (Silver Spring, MD). NR 28 TC 2 Z9 2 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 984 EP 988 DI 10.4269/ajtmh.2011.11-0260 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000005 PM 22144431 ER PT J AU Myint, HY Berman, J Walker, L Pybus, B Melendez, V Baird, JK Ohrt, C AF Myint, Hla Y. Berman, Jonathan Walker, Larry Pybus, Brandon Melendez, Victor Baird, J. Kevin Ohrt, Colin TI Review: Improving the Therapeutic Index of 8-Aminoquinolines by the Use of Drug Combinations: Review of the Literature and Proposal for Future Investigations SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Review ID PRIMAQUINE; MALARIA; CARBOXYPRIMAQUINE; IDENTIFICATION; CHLOROQUINE; METABOLISM; QUINACRINE AB Because 8-aminoquinolines affect critical survival stages of Plasmodium parasites, treatment and control of malaria could be markedly improved by more widespread use of these drugs; however, hemolytic toxicity, which is widely prevalent in G6PD-deficient patients, severely constrains this use. Primaquine was approved more than 50 years ago after extensive clinical testing. Review of the mid-20th century literature in the light of present understanding of pharmacokinetics and metabolism suggests that manipulation of these factors might dissociate 8-aminoquinoline efficacy from toxicity and lead to an improved therapeutic index. C1 [Myint, Hla Y.; Berman, Jonathan; Pybus, Brandon; Melendez, Victor; Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. [Walker, Larry] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA. [Walker, Larry] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA. [Baird, J. Kevin] Eijkman Oxford Clin Res Unit, Jakarta, Indonesia. [Baird, J. Kevin] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, England. RP Ohrt, C (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. EM Hya.yin.myint@us.army.mil; Jbe9320457@aol.com; lwalker@olemiss.edu; brandon.pybus@us.army.mil; Victor.melendezsr@us.army.mil; jkevinbaird@yahoo.com; colin.ohrt@us.army.mil FU US Army Medical Research and Material Command [USAMRMC] [W81-XWH-07-2-0095]; Telemedicine and Advanced Technology Research Center [TATRC] at Fort Detrick, MD; Department of Defense FX This project was partially supported by Grant W81-XWH-07-2-0095 to the University of Mississippi (awarded and administered by the US Army Medical Research and Material Command [USAMRMC] and the Telemedicine and Advanced Technology Research Center [TATRC] at Fort Detrick, MD and the Department of Defense). The views, opinions, and/or findings contained in this paper are the authors and do not necessarily reflect the views of the Department of Defense; they should not be construed as an official Department of Defense/Army position, policy, or decision unless so designated by other documentation. The American Society of Tropical Medicine and Hygiene (ASTMH) assisted with publication expenses NR 32 TC 21 Z9 21 U1 1 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 1010 EP 1014 DI 10.4269/ajtmh.2011.11-0498 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000010 PM 22144436 ER PT J AU Steinhardt, LC Magill, AJ Arguin, PM AF Steinhardt, Laura C. Magill, Alan J. Arguin, Paul M. TI Review: Malaria Chemoprophylaxis for Travelers to Latin America SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Review ID PLASMODIUM-VIVAX MALARIA; PLACEBO-CONTROLLED TRIAL; NONIMMUNE COLOMBIAN SOLDIERS; DOUBLE-BLIND; UNITED-STATES; ATOVAQUONE-PROGUANIL; PRIMAQUINE PROPHYLAXIS; SURVEILLANCE; MEFLOQUINE; PREVENTION AB Because of recent declining malaria transmission in Latin America, some authorities have recommended against chemoprophylaxis for most travelers to this region. However, the predominant parasite species in Latin America, Plasmodium vivax, can form hypnozoites sequestered in the liver, causing malaria relapses. Additionally, new evidence shows the potential severity of vivax infections, warranting continued consideration of prophylaxis for travel to Latin America. Individualized travel risk assessments are recommended and should consider travel locations, type, length, and season, as well as probability of itinerary changes. Travel recommendations might include no precautions, mosquito avoidance only, or mosquito avoidance and chemoprophylaxis. There are a range of good options for chemoprophylaxis in Latin America, including atovaquone-proguanil, doxycycline, mefloquine, and-in selected areas-chloroquine. Primaquine should be strongly considered for nonpregnant, G6PD-nondeficient patients traveling to vivax-endemic areas of Latin America, and it has the added benefit of being the only drug to protect against malaria relapses. C1 [Steinhardt, Laura C.; Arguin, Paul M.] Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Atlanta, GA 30333 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Steinhardt, LC (reprint author), Ctr Dis Control & Prevent, Malaria Branch, Div Parasit Dis & Malaria, Mailstop A06,1600 Clifton Road NE, Atlanta, GA 30333 USA. EM LSteinhardt@cdc.gov; alan.magill@us.army.mil; PArguin@cdc.gov NR 78 TC 9 Z9 9 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD DEC PY 2011 VL 85 IS 6 BP 1015 EP 1024 DI 10.4269/ajtmh.2011.11-0464 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 858FJ UT WOS:000297781000011 PM 22144437 ER PT J AU Koehler, JW Dupuy, LC Garrison, AR Beitzel, BF Richards, MJ Ripoll, DR Wallqvist, A Teh, SY Vaewhongs, AA Vojdani, FS Padgett, HS Schmaljohn, CS AF Koehler, Jeffrey W. Dupuy, Lesley C. Garrison, Aura R. Beitzel, Brett F. Richards, Michelle J. Ripoll, Daniel R. Wallqvist, Anders Teh, Shia-Yen Vaewhongs, Andrew A. Vojdani, Fakhrieh S. Padgett, Hal S. Schmaljohn, Connie S. TI Novel plant-derived recombinant human interferons with broad spectrum antiviral activity SO ANTIVIRAL RESEARCH LA English DT Article DE Type 1 interferons; Ebola virus; Rift Valley fever virus; Venezuelan equine encephalitis virus; Monkeypox virus ID CONSENSUS INTERFERON; RECEPTOR-BINDING; VIRUS-INFECTION; MONKEYPOX VIRUS; PROTEIN; SAFETY; EXPRESSION; SECRETION; LYMPHOMA; EFFICACY AB Type 1 interferons (IFN5) are potent mediators of the innate immune response to viral infection. IFNs released from infected cells bind to a receptor (IFNAR) on neighboring cells, triggering signaling cascades that limit further infection. Subtle variations in amino acids can alter IFNAR binding and signaling outcomes. We used a new gene crossbreeding method to generate hybrid, type I human IFNs with enhanced antiviral activity against four dissimilar, highly pathogenic viruses. Approximately 1400 novel IFN genes were expressed in plants, and the resultant IFN proteins were screened for antiviral activity. Comparing the gene sequences of a final set of 12 potent IFNs to those of parent genes revealed strong selection pressures at numerous amino acids. Using three-dimensional models based on a recently solved experimental structure of IFN bound to IFNAR, we show that many but not all of the amino acids that were highly selected for are predicted to improve receptor binding. Published by Elsevier B.V. C1 [Koehler, Jeffrey W.; Dupuy, Lesley C.; Garrison, Aura R.; Beitzel, Brett F.; Richards, Michelle J.; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Ripoll, Daniel R.; Wallqvist, Anders] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. [Teh, Shia-Yen] Univ Calif Irvine, Irvine, CA 92697 USA. [Vaewhongs, Andrew A.; Vojdani, Fakhrieh S.; Padgett, Hal S.] Novici Biotech LLC, Vacaville, CA 95688 USA. RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@amedd.army.mil OI wallqvist, anders/0000-0002-9775-7469; Koehler, Jeffrey/0000-0003-3225-6599 FU National Research Council; Defense Threat Reduction Agency (DTRA); U.S. Department of Defense under the High Performance Computing Software Applications Institutes (HSAI) initiative FX We acknowledge Dr. Jason Paragas and Dr. Steven Fong for helping to establish this project. JWK and BFB were supported by National Research Council Postdoctoral Research Associateships. This research was supported in part by the Defense Threat Reduction Agency (DTRA) and the U.S. Department of Defense High Performance Computing Modernization Program (HPCMP) under the High Performance Computing Software Applications Institutes (HSAI) initiative. This research was performed under a U.S. Army Medical Research and Material Command Cooperative Research and Development Agreement between USAMRIID and Novici Biotech, LLC. The opinions, interpretations, conclusions, and recommendations contained herein are those of the authors and are not necessarily endorsed by the U.S. Army. NR 38 TC 2 Z9 2 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD DEC PY 2011 VL 92 IS 3 BP 461 EP 469 DI 10.1016/j.antiviral.2011.10.008 PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 862XJ UT WOS:000298127100008 PM 22020161 ER PT J AU Orestes, MI Fileta, B Haymes, S Brietzke, SE AF Orestes, Michael I. Fileta, Bader Haymes, Snezana Brietzke, Scott E. TI Effects of Thrombolytic Agents on Tympanostomy Tubes Occluded by Blood Clots SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID BIOFILM FORMATION; EAR AB Objective: To investigate the efficacy of various topical applications in opening a clotted tympanostomy tube (TT) using an in vitro model. Design: In vitro clinical trial. Interventions: Fresh human blood was allowed to clot in the lumen of TTs. Seven agents were tested: 0.9% saline (control), 1-mg/mL alteplase, 100-U/mL unfractionated heparin, 3% hydrogen peroxide (H(2)O(2)), 3% acetic acid, 5% acetic acid, and a mixture of 3% H(2)O(2) and 3% acetic acid. Each agent was added twice a day for 14 days to TTs that were incubated and humidified to simulate ear canal conditions. The tubes were analyzed with binocular microscopy to determine the status of the obstruction. Results: A total of 16 trials per agent, including a saline control, were performed. The saline control, alteplase, and heparin failed to open any TTs in any of the trials. Compared with the control, H(2)O(2) also was not effective (P=.23). Acetic acid was increasingly effective, with a 3% concentration completely clearing 5 of 16 tubes and a 5% concentration completely clearing 11 of 16 tubes (P=.006). The addition of 3% H(2)O(2) to 3% acetic acid did not significantly increase clearance (P=.21). Conclusions: Thrombolytic agents and H(2)O(2) were not effective in resolving TTs that were clotted with blood in an in vitro environment simulating the ear canal. Increasing concentrations of acetic acid are increasingly effective in this capacity. C1 [Orestes, Michael I.; Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. [Fileta, Bader; Haymes, Snezana] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. EM SEBrietzke@msn.com NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD DEC PY 2011 VL 137 IS 12 BP 1222 EP 1225 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 864SN UT WOS:000298260500008 ER PT J AU Kotwal, RS Montgomery, HR Kotwal, BM Champion, HR Butler, FK Mabry, RL Cain, JS Blackbourne, LH Mechler, KK Holcomb, JB AF Kotwal, Russ S. Montgomery, Harold R. Kotwal, Bari M. Champion, Howard R. Butler, Frank K., Jr. Mabry, Robert L. Cain, Jeffrey S. Blackbourne, Lorne H. Mechler, Kathy K. Holcomb, John B. TI Eliminating Preventable Death on the Battlefield SO ARCHIVES OF SURGERY LA English DT Article ID COMBAT CASUALTY CARE; OPERATION-ENDURING-FREEDOM; MAJOR LIMB TRAUMA; IRAQI-FREEDOM; INJURY; WAR; AFGHANISTAN; MANAGEMENT; MEDICINE; VIETNAM AB Objective: To evaluate battlefield survival in a novel command-directed casualty response system that comprehensively integrates Tactical Combat Casualty Care guidelines and a prehospital trauma registry. Design: Analysis of battle injury data collected during combat deployments. Setting: Afghanistan and Iraq from October 1, 2001, through March 31, 2010. Patients: Casualties from the 75th Ranger Regiment, US Army Special Operations Command. Main Outcome Measures: Casualties were scrutinized for preventable adverse outcomes and opportunities to improve care. Comparisons were made with Department of Defense casualty data for the military as a whole. Results: A total of 419 battle injury casualties were incurred during 7 years of continuous combat in Iraq and 8.5 years in Afghanistan. Despite higher casualty severity indicated by return-to-duty rates, the regiment's rates of 10.7% killed in action and 1.7% who died of wounds were lower than the Department of Defense rates of 16.4% and 5.8%, respectively, for the larger US military population (P=.04 and P=.02, respectively). Of 32 fatalities incurred by the regiment, none died of wounds from infection, none were potentially survivable through additional prehospital medical intervention, and 1 was potentially survivable in the hospital setting. Substantial prehospital care was provided by nonmedical personnel. Conclusions: A command-directed casualty response system that trains all personnel in Tactical Combat Casualty Care and receives continuous feedback from prehospital trauma registry data facilitated Tactical Combat Casualty Care performance improvements centered on clinical outcomes that resulted in unprecedented reduction of killed-in-action deaths, casualties who died of wounds, and preventable combat death. This data-driven approach is the model for improving prehospital trauma care and casualty outcomes on the battlefield and has considerable implications for civilian trauma systems. C1 [Kotwal, Russ S.; Montgomery, Harold R.; Kotwal, Bari M.] USA, Special Operat Command, Ft Bragg, NC 28310 USA. [Champion, Howard R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Butler, Frank K., Jr.; Mabry, Robert L.; Cain, Jeffrey S.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Mechler, Kathy K.] Texas A&M Hlth Sci Ctr, Rural & Community Hlth Inst, Bryan, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA. RP Kotwal, RS (reprint author), USA, Special Operat Command, 2929 Desert Storm Dr, Ft Bragg, NC 28310 USA. EM russ.kotwal@us.army.mil NR 47 TC 102 Z9 104 U1 6 U2 19 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD DEC PY 2011 VL 146 IS 12 BP 1349 EP 1357 DI 10.1001/archsurg.2011.213 PG 9 WC Surgery SC Surgery GA 864RF UT WOS:000298256900004 PM 21844425 ER PT J AU Toren, KL Marquart, JD AF Toren, Kristen L. Marquart, Jason D. TI Fractional Thermoablation Using an Erbium-Doped Yttrium Aluminum Garnet Fractionated Laser for the Treatment of Pulsed Dye Laser-Resistant Port Wine Stain Birthmarks SO DERMATOLOGIC SURGERY LA English DT Editorial Material C1 [Toren, Kristen L.; Marquart, Jason D.] Walter Reed Army Med Ctr, Dept Dermatol, Mohs Surg Procedural Dermatol Serv, Washington, DC 20307 USA. RP Toren, KL (reprint author), 30 Brough Lane 306, Hampton, VA 23669 USA. EM kltoren@gmail.com NR 7 TC 2 Z9 3 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD DEC PY 2011 VL 37 IS 12 BP 1791 EP 1794 DI 10.1111/j.1524-4725.2011.02160.x PG 4 WC Dermatology; Surgery SC Dermatology; Surgery GA 866BS UT WOS:000298355200015 PM 22092921 ER PT J AU Tesfa, TK Tarboton, DG Watson, DW Schreuders, KAT Baker, ME Wallace, RM AF Tesfa, Teklu K. Tarboton, David G. Watson, Daniel W. Schreuders, Kimberly A. T. Baker, Matthew E. Wallace, Robert M. TI Extraction of hydrological proximity measures from DEMs using parallel processing SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE Digital elevation model analysis; Flow distance; Hydrological proximity measures; Message passing interface; Parallel computation; Topographic attributes ID DIGITAL ELEVATION MODELS; SOIL PROPERTIES; LAND-USE; FLOW; PREDICTION; NETWORKS; AREAS; COMPUTATION; STREAMS; BASIN AB Land surface topography is one of the most important terrain properties which impact hydrological, geomorphological, and ecological processes active on a landscape. In our previous efforts to develop a soil depth model based upon topographic and land cover variables, we derived a set of hydrological proximity measures (HPMs) from a Digital Elevation Model (DEM) as potential explanatory variables for soil depth. These HPMs are variations of the distance up to ridge points (cells with no incoming flow) and variations of the distance down to stream points (cells with a contributing area greater than a threshold), following the flow path. The HPMs were computed using the D-infinity flow model that apportions flow between adjacent neighbors based on the direction of steepest downward slope on the eight triangular facets constructed in a 3 x 3 grid cell window using the center cell and each pair of adjacent neighboring grid cells in turn. The D-infinity model typically results in multiple flow paths between 2 points on the topography, with the result that distances may be computed as the minimum, maximum or average of the individual flow paths. In addition, each of the HPMs, are calculated vertically, horizontally, and along the land surface. Previously, these HPMs were calculated using recursive serial algorithms which suffered from stack overflow problems when used to process large datasets, limiting the size of DEMs that could be analyzed. To overcome this limitation, we developed a message passing interface (MPI) parallel approach designed to both increase the size and speed with which these HPMs are computed. The parallel HPM algorithms spatially partition the input grid into stripes which are each assigned to separate processes for computation. Each of those processes then uses a queue data structure to order the processing of cells so that each cell is visited only once and the cross-process communications that are a standard part of MPI are handled in an efficient manner. This parallel approach allows efficient analysis of much larger DEMs than were possible using the serial recursive algorithms. The HPMs given here may also have other, more general modeling applicability in hydrology, geomorphology and ecology, and so are described here from a general perspective. In this paper, we present the definitions of the HPMs, the serial and parallel algorithms used in their computation and their potential applications. Published by Elsevier Ltd. C1 [Tesfa, Teklu K.] Pacific NW Natl Lab, Hydrol Grp, Richland, WA 99352 USA. [Tarboton, David G.; Schreuders, Kimberly A. T.] Utah State Univ, Dept Civil & Environm Engn, Logan, UT 84322 USA. [Watson, Daniel W.] Utah State Univ, Dept Comp Sci, Logan, UT 84322 USA. [Baker, Matthew E.] Univ Maryland, Dept Geog & Environm Syst, Baltimore, MD 21201 USA. [Wallace, Robert M.] USA, Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS USA. RP Tesfa, TK (reprint author), Pacific NW Natl Lab, Hydrol Grp, POB 999, Richland, WA 99352 USA. EM teklu.tesfa@pnnl.gov RI Tarboton, David/G-8972-2011; Baker, Matthew/I-2839-2014 OI Tarboton, David/0000-0002-1998-3479; Baker, Matthew/0000-0001-5069-0204 FU Inland Northwest Research Alliance; Cooperative Institute for Coastal and Estuarine Environmental Technology (CICEET); National Oceanic and Atmospheric Administration [NA06NOS4190167]; University of New Hampshire; US Army Research and Development Center [W9124Z-08-P-0420] FX This work was funded in part by the Inland Northwest Research Alliance; the Cooperative Institute for Coastal and Estuarine Environmental Technology (CICEET), a partnership of the National Oceanic and Atmospheric Administration (NA06NOS4190167) and the University of New Hampshire; and the US Army Research and Development Center under contract number W9124Z-08-P-0420. NR 60 TC 35 Z9 39 U1 2 U2 24 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD DEC PY 2011 VL 26 IS 12 BP 1696 EP 1709 DI 10.1016/j.envsoft.2011.07.018 PG 14 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA 864WD UT WOS:000298270300028 ER PT J AU Starek, MJ Mitasova, H Hardin, E Weaver, K Overton, M Harmon, RS AF Starek, Michael J. Mitasova, Helena Hardin, Eric Weaver, Katherine Overton, Margery Harmon, Russell S. TI Modeling and analysis of landscape evolution using airborne, terrestrial, and laboratory laser scanning SO GEOSPHERE LA English DT Article ID LIDAR DATA; SOIL-EROSION; TOPOGRAPHIC LIDAR; NORTH-CAROLINA; WATER; UNCERTAINTY; TILLAGE; SERIES; DEMS; FLOW AB Current laser scanning (Lidar, light detection and ranging) technologies span a wide range of survey extent and resolutions, from regional airborne Lidar mapping and terrestrial Lidar field surveys to laboratory systems utilizing indoor three-dimensional (3D) laser scanners. Proliferation in Lidar technology and data collection enables new approaches for monitoring and analysis of landscape evolution. For example, repeat Lidar surveys that generate a time series of point cloud data provide an opportunity to transition from traditional, static representations of topography to terrain abstraction as a 3D dynamic layer. Three case studies are presented to illustrate novel techniques for landscape evolution analysis based on time series of Lidar data: (1) application of multi-year airborne Lidar surveys to a study of a dynamic coastal region, where the change is driven by eolian sediment transport, wave-induced beach erosion, and human intervention; (2) monitoring of vegetation growth and the impact of landscape structure on overland flow in an agricultural field using terrestrial laser scanning; and (3) investigation of landscape design impacts on overland water flow and other physical processes using a tangible geospatial modeling system. The presented studies demonstrate new insights into landscape evolution in different environments that can be gained from Lidar scanning spanning 1.0-0.001 m resolutions with geographic information system analysis capabilities. C1 [Starek, Michael J.; Mitasova, Helena; Hardin, Eric; Weaver, Katherine] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA. [Starek, Michael J.; Mitasova, Helena; Hardin, Eric; Weaver, Katherine] N Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA. [Overton, Margery] N Carolina State Univ, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA. [Harmon, Russell S.] USA, Div Environm Sci, Army Res Off, Res Lab, Durham, NC 27703 USA. RP Starek, MJ (reprint author), N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Box 8208, Raleigh, NC 27695 USA. OI Mitasova, Helena/0000-0002-6906-3398 FU U.S. Army Research Office; North Carolina Sea Grant FX The support of the U.S. Army Research Office and North Carolina Sea Grant is gratefully acknowledged. We thank Karl Wegmann for his review and valuable comments. We also thank the anonymous referees for their insightful comments that led to substantial improvements in the organization and focus of the discussion. The airborne Lidar data were acquired and made publicly available by the U.S Geological Survey-National Oceanic and Atmospheric Administration-National Aeronautics and Space Administration Coastal Change Program, North Carolina Flood Mapping Program, and the U. S. Army Corps of Engineers Joint Airborne Lidar Bathymetry Technical Center of Expertise. This research was performed in part while Starek held a National Research Council Research Associateship Fellowship at the U. S. Army Research Office. NR 49 TC 12 Z9 12 U1 7 U2 41 PU GEOLOGICAL SOC AMER, INC PI BOULDER PA PO BOX 9140, BOULDER, CO 80301-9140 USA SN 1553-040X J9 GEOSPHERE JI Geosphere PD DEC PY 2011 VL 7 IS 6 BP 1340 EP 1356 DI 10.1130/GES00699.1 PG 17 WC Geosciences, Multidisciplinary SC Geology GA 863QH UT WOS:000298180700008 ER PT J AU Balasubramanian, S Creech, G Wilson, J Yoder, SM McCue, JJ Verhelst, M Khalil, W AF Balasubramanian, S. Creech, G. Wilson, J. Yoder, S. M. McCue, J. J. Verhelst, M. Khalil, W. TI Systematic Analysis of Interleaved Digital-to-Analog Converters SO IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS LA English DT Article DE DDRF-DAC; digital-to-analog converters (DACs); interleaving; reconstruction ID DAC AB A generalized theoretical analysis of interleaved digital-to-analog converters (DACs) is presented to explain the cancellation of image replicas. A new RF-DAC architecture comprising N-parallel DACs and using both clock and hold interleaving structure is proposed. The architecture is analyzed using a general mathematical model that can be extended to other types of interleaved DACs. Additional benefits of the proposed architecture, including bandwidth and resolution enhancements, are investigated. The model is extended to analyze return-to-zero variants of this architecture with a variable hold time period. The effect of different path mismatches is further examined. C1 [Yoder, S. M.; McCue, J. J.; Khalil, W.] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA. [Creech, G.] USAF, Adv Sensor Components Branch, Res Lab, Hanscom Afb, MA 01731 USA. [Wilson, J.] USA, Res Lab, Washington, DC 20314 USA. [Verhelst, M.] Katholieke Univ Leuven, Dept Elect Engn, B-3001 Heverlee, Belgium. RP Balasubramanian, S (reprint author), Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA. EM balasubs@ece.osu.edu RI Khalil, Waleed/H-1065-2012; Verhelst, Marian/E-5739-2011 OI Verhelst, Marian/0000-0003-3495-9263 FU National Science Foundation [1032604]; Air Force Research Laboratory FX This work was supported in part by the National Science Foundation under NSF Grant 1032604 and in part by the Air Force Research Laboratory. This paper was recommended by Associate Editor T.-C. Lee. NR 12 TC 11 Z9 12 U1 1 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1549-7747 J9 IEEE T CIRCUITS-II JI IEEE Trans. Circuits Syst. II-Express Briefs PD DEC PY 2011 VL 58 IS 12 BP 882 EP 886 DI 10.1109/TCSII.2011.2172526 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA 861XA UT WOS:000298052500021 ER PT J AU Qiu, JX Darwish, AM Viveiros, EA Kingkeo, K Hung, HA AF Qiu, Joe X. Darwish, Ali M. Viveiros, Edward A. Kingkeo, Khamsouk Hung, H. Alfred TI Linearity Characterization and Optimization of Millimeter-Wave GaN HEMTs SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article; Proceedings Paper CT International Microwave Symposium CY JUN 05-10, 2011 CL Baltimore, MA DE AlGaN; GaN; high-electron mobility transistor (HEMT); intermodulation distortion (IMD); linearity; millimeter-wave (mmW); wide bandgap; 16 quadrature-amplitude modulation (16QAM) AB This paper presents the first comprehensive study of the linearity characteristics of GaN/SiC high-electron mobility transistors (HEMTs) at millimeter-wave (mmW). Similar size devices from three sources are compared using AM-AM, AM-PM, two-tone, and 16-quadrature-amplitude modulation (16QAM) modulated waveforms measurements at 31.5 GHz. Additionally, error vector magnitude (EVM) and spectrum regrowth [adjacent channel power ratio (ACPR)] data are also presented. The results were measured, using a unique digital waveform system integrated with a mmW (50-GHz) load-pull system, for HEMTs at different classes of operation: A, AB, and B. In all devices, it is observed that a "balanced AB" (b-AB) class of device bias condition where linearity and efficiency are simultaneously optimized. A linearity figure of merit FOMlinearity, based on single-tone power measurements, is defined and calculated for each class. The FOMlinearity closely correlates with linearity performance of the HEMT under two-tone and digitally modulated drive conditions. Compared with class A, at a fixed output power, a b-AB class showed a 5-10-dB improvement in intermodulation distortions, combined with 1.2x to 1.9x enhancement in drain efficiency. The characterization methodology and derived FOMlinearity should benefit monolithic microwave integrated circuit (MMIC) designers to optimize the operation of GaN HEMTs. The results also indicate that GaN HEMTs can provide linearity characteristics suitable for applications such as satellite communications, while maintaining high efficiency and power density. C1 [Qiu, Joe X.; Darwish, Ali M.; Viveiros, Edward A.; Kingkeo, Khamsouk; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA. RP Qiu, JX (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM joe.x.qiu.civ@mail.mil NR 21 TC 6 Z9 6 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9480 EI 1557-9670 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD DEC PY 2011 VL 59 IS 12 SI SI BP 3419 EP 3427 DI 10.1109/TMTT.2011.2171986 PN 2 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA 861WX UT WOS:000298052000018 ER PT J AU Mitliagkas, I Sidiropoulos, ND Swami, A AF Mitliagkas, Ioannis Sidiropoulos, Nicholas D. Swami, Ananthram TI Joint Power and Admission Control for Ad-Hoc and Cognitive Underlay Networks: Convex Approximation and Distributed Implementation SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS LA English DT Article DE Power control; admission control; convex optimization; distributed implementation; dual decomposition; subgradient; ad-hoc; peer-to-peer; cognitive radio networks ID SPECTRUM ACCESS; RADIO NETWORKS; ALGORITHMS; SYSTEMS AB Power control is important in interference-limited cellular, ad-hoc, and cognitive underlay networks, when the objective is to ensure a certain quality of service to each connection. Power control has been extensively studied in this context, including distributed algorithms that are particularly appealing in ad-hoc and cognitive settings. A long-standing issue is that the power control problem may be infeasible, thus requiring appropriate admission control. The power and admission control parts of the problem are tightly coupled, but the joint optimization problem is NP-hard. We begin with a convenient reformulation which enables a disciplined convex approximation approach. This leads to a centralized approximate solution that is numerically shown to outperform the prior art, and even yield close to optimal results in certain cases - at affordable complexity. The issue of imperfect channel state information is also considered. A distributed implementation is then developed, which alternates between distributed approximation and distributed deflation reaching consensus on a user to drop, when needed. Both phases require only local communication and computation, yielding a relatively lightweight distributed algorithm with the same performance as its centralized counterpart. C1 [Sidiropoulos, Nicholas D.] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. [Mitliagkas, Ioannis; Sidiropoulos, Nicholas D.] Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Greece. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Sidiropoulos, ND (reprint author), Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA. EM nikos@ece.umn.edu FU ARL/ERO [W911NF-09-1-0004] FX I. Mitliagkas and N. D. Sidiropoulos were with the Department of Electronic and Computer Engineering, Technical University of Crete, 73100 Chania - Crete, Greece, where the work was supported in part by ARL/ERO contract W911NF-09-1-0004. I. Mitliagkas is now at UT Austin. NR 36 TC 34 Z9 34 U1 0 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1276 J9 IEEE T WIREL COMMUN JI IEEE Trans. Wirel. Commun. PD DEC PY 2011 VL 10 IS 12 BP 4110 EP 4121 DI 10.1109/TWC.2011.100811.101381 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 865SB UT WOS:000298329500018 ER PT J AU Niu, N Lopez, AY Cheng, JRC AF Niu, N. Lopez, A. Y. Cheng, J-R C. TI Using soft systems methodology to improve requirements practices: an exploratory case study SO IET SOFTWARE LA English DT Article ID MANAGEMENT AB Soft systems methodology (SSM) should offer substantial benefits in managing expectations and requirements for a software-intensive system, but the benefits have not yet been examined empirically. This study reports an exploratory case study investigating the hypothesis that 'soft systems approach would identify all the flaws in requirements practices and suggest improvements suited to an organisation's context'. The authors analysed problematic requirements practices in an ongoing software-intensive socio-technical project, modelled potential changes and asked the project team to assess the organisational fit of these changes. The authors further monitored the requirements engineering improvements that the project team made according to the case study. The authors conclude that SSM could indeed uncover a relatively complete set of flaws in requirements practices. Although not all suggested changes were regarded as necessary, the implemented changes had contributed positively to the organisation's requirements engineering improvements. C1 [Niu, N.; Lopez, A. Y.] Mississippi State Univ, Dept Comp Sci & Engn, Mississippi State, MS 39762 USA. [Cheng, J-R C.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Niu, N (reprint author), Mississippi State Univ, Dept Comp Sci & Engn, Box 9637, Mississippi State, MS 39762 USA. EM niu@cse.msstate.edu NR 38 TC 10 Z9 10 U1 1 U2 4 PU INST ENGINEERING TECHNOLOGY-IET PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND SN 1751-8806 EI 1751-8814 J9 IET SOFTW JI IET Softw. PD DEC PY 2011 VL 5 IS 6 BP 487 EP 495 DI 10.1049/iet-sen.2010.0096 PG 9 WC Computer Science, Software Engineering SC Computer Science GA 865DN UT WOS:000298291100001 ER PT J AU Verter, EE Gisel, TE Yang, PG Johnson, AJ Redmond, RW Kochevar, IE AF Verter, E. Eri Gisel, Thomas E. Yang, Penggao Johnson, Anthony J. Redmond, Robert W. Kochevar, Irene E. TI Light-Initiated Bonding of Amniotic Membrane to Cornea SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Article ID PHOTODYNAMIC CROSS-LINKING; PHOTOCHEMICAL KERATODESMOS; SINGLET OXYGEN; FIBRIN GLUE; INCISIONS; COLLAGEN; REPAIR; SKIN; TEMPERATURE; MODEL AB PURPOSE. Suturing amniotic membrane to cornea during surgery is time consuming, and sutures may further damage the eye. The authors introduce a novel sutureless, light-activated technique that securely attaches amnion to cornea through protein-protein crosslinks. METHODS. Cryopreserved human amniotic membrane, stained with Rose Bengal (RB), was placed over a full-thickness wound in deepithelialized rabbit cornea and was treated with green laser. The intraocular pressure that broke the seal (IOP(L)) was measured, and adhesion was measured with a peel test. The influences on bonding strength of fluence, irradiance, RB concentration, and amnion surface bonded were measured. Epithelial cell migration on treated amnion and keratocyte viability after bonding were also measured. The involvement in the bonding mechanism of oxygen, singlet oxygen, and association of RB with stromal collagen was investigated. RESULTS. Sealing amniotic membrane over cornea using 0.1% RB and 150 J/cm(2) at 532 nm produced an IOP L of 261 +/- 77 mm Hg ex vivo and 448 mm +/- 212 mm Hg in vivo. The ex vivo IOP L increased with increasing fluence (50-150 J/cm(2)). Equivalent IOP L was produced for bonding basement membrane or stromal amnion surfaces. The bonding treatment was not toxic to keratocytes but slightly reduced the migration of corneal epithelial cells on amnion ex vivo. Mechanism studies indicated that RB forms two complexes with amnion stromal collagen, that bonding requires oxygen, and that singlet oxygen mediates protein crosslinking. CONCLUSIONS. A rapid, light-activated technique produces strong, immediate bonding between amnion and cornea and merits further evaluation for ocular surface surgeries. (Invest Ophthalmol Vis Sci. 2011;52:9470-9477) DOI:10.1167/iovs.11-7248 C1 [Verter, E. Eri; Gisel, Thomas E.; Yang, Penggao; Redmond, Robert W.; Kochevar, Irene E.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Boston, MA 02114 USA. [Yang, Penggao] 3 Peoples Hosp, Dept Burns & Plast Surg, Shanghai, Peoples R China. [Johnson, Anthony J.] Brooke Army Med Ctr, Dept Ophthalmol, San Antonio, TX USA. RP Kochevar, IE (reprint author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Wellman Ctr Photomed, Thier Bldg,Room 212,55 Fruit St, Boston, MA 02114 USA. EM kochevar@helix.mgh.harvard.edu FU US Department of the Army [W81XWH-09-2-0050]; Air Force Office of Scientific Research [FA9550-10-1-0537] FX Supported by US Department of the Army Award number W81XWH-09-2-0050 and Air Force Office of Scientific Research Grant FA9550-10-1-0537. NR 37 TC 18 Z9 20 U1 4 U2 8 PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC PI ROCKVILLE PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD DEC PY 2011 VL 52 IS 13 BP 9470 EP 9477 DI 10.1167/iovs.11-7248 PG 8 WC Ophthalmology SC Ophthalmology GA 869WC UT WOS:000298628200027 PM 22058339 ER PT J AU Gentile, GP AF Gentile, Gian P. TI Beneficial Bombing: The Progressive Foundations of American Air Power, 1917-1945. SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Gentile, Gian P.] US Mil Acad, West Point, NY 10996 USA. RP Gentile, GP (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 EI 1945-2314 J9 J AM HIST JI J. Am. Hist. PD DEC PY 2011 VL 98 IS 3 BP 872 EP U816 DI 10.1093/jahist/jar492 PG 2 WC History SC History GA 865PV UT WOS:000298323700095 ER PT J AU Bentsen, C McLaughlin, L Mitchell, E Ferrera, C Liska, S Myers, R Peel, S Swenson, P Gadelle, S Shriver, MK AF Bentsen, Christopher McLaughlin, Lisa Mitchell, Elizabeth Ferrera, Carol Liska, Sally Myers, Robert Peel, Sheila Swenson, Paul Gadelle, Stephane Shriver, M. Kathleen TI Performance evaluation of the Bio-Rad Laboratories GS HIV Combo Ag/Ab EIA, a 4th generation HIV assay for the simultaneous detection of HIV p24 antigen and antibodies to HIV-1 (groups M and O) and HIV-2 in human serum or plasma SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE 4th generation; Combination; HIV antigen; Antibody; Acute ID IMMUNODEFICIENCY-VIRUS TYPE-2; UNITED-STATES; INFECTION; AIDS; BLOOD; IDENTIFICATION; RETROVIRUS; DIAGNOSIS; SEQUENCE; SUBTYPES AB Background: A multi-center study was conducted to evaluate the Bio-Rad GS HIV Combo Ag/Ab EIA, a 4th generation HIV-1/HIV-2 assay for the simultaneous detection of HIV p24 antigen and antibodies to HIV-1 (groups M and O) and HIV-2 in human serum or plasma in adult and pediatric populations. Objectives: The objectives of the study were to assess assay performance for the detection of acute HIV infections; sensitivity in known HIV positive samples; percent agreement with HIV status; specificity in low and high risk individuals of unknown HIV status; and to compare assay performance to a 3rd generation HIV assay. Study design: The evaluation included testing 9150 samples at four U. S. clinical trial sites, using three kit lots. Unlinked samples were from routine testing, repositories or purchased from vendors. Results: GS HIV Combo Ag/Ab EIA detection in samples from individuals in two separate populations with acute HIV infection was 95.2% (20/21) and 86.4% (38/44). Sensitivity was 100% (1603/1603) in known antibody positive [HIV-1 Groups M and O, and HIV-2] samples. HIV p24 antigen detection was 100% (53/53) in HIV-1 culture supernatants. HIV-1 seroconversion panel detection improved by a range of 0-20 days compared to a 3rd generation HIV test. Specificity was 99.9% (5989/5996) in low risk, 99.9% (959/960) in high risk and 100% (100/100) in pediatric populations. Conclusion: The GS HIV Combo Ag/Ab EIA significantly reduced the diagnostic window when compared to the 3rd generation screening assay, enabling earlier diagnosis of HIV infection. The performance parameters of the Bio-Rad GS HIV Combo Ag/Ab EIA are well suited for use in HIV diagnostic settings. (C) 2011 Elsevier B. V. All rights reserved. C1 [Bentsen, Christopher; McLaughlin, Lisa; Mitchell, Elizabeth; Ferrera, Carol; Shriver, M. Kathleen] Bio Rad Labs Inc, Redmond, WA 98052 USA. [Liska, Sally] San Francisco Dept Publ Hlth Labs, San Francisco, CA 94102 USA. [Myers, Robert] Maryland Dept Hlth & Mental Hyg, Baltimore, MD 21201 USA. [Peel, Sheila] Walter Reed Army Inst Res, Rockville, MD 20850 USA. [Swenson, Paul] Seattle King Cty Dept Publ Hlth, Seattle, WA 98104 USA. [Gadelle, Stephane] Bio Rad Labs Inc, F-92430 Marnes La Coquette, France. RP Bentsen, C (reprint author), Bio Rad Labs Inc, 6565 185th Ave NE, Redmond, WA 98052 USA. EM christopher_bentsen@bio-rad.com FU Bio-Rad Laboratories FX This study was funded by Bio-Rad Laboratories. NR 21 TC 19 Z9 19 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 EI 1873-5967 J9 J CLIN VIROL JI J. Clin. Virol. PD DEC PY 2011 VL 52 SU 1 BP S57 EP S61 DI 10.1016/j.jcv.2011.09.023 PG 5 WC Virology SC Virology GA 863FZ UT WOS:000298149500012 PM 21995929 ER PT J AU Kragh, JF Littrel, ML Jones, JA Walters, TJ Baer, DG Wade, CE Holcomb, JB AF Kragh, John F., Jr. Littrel, Michelle L. Jones, John A. Walters, Thomas J. Baer, David G. Wade, Charles E. Holcomb, John B. TI BATTLE CASUALTY SURVIVAL WITH EMERGENCY TOURNIQUET USE TO STOP LIMB BLEEDING SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article DE tourniquet; trauma; major; military; limb injury; hemorrhage control ID EXTREMITY ARTERIAL HEMORRHAGES; OPERATION-IRAQI-FREEDOM; INJURY; DEATH; CARE; EXPERIENCE; TRAUMA; SWINE; WAR AB Background: In a previous study conducted at a combat support hospital in Iraq, we reported the major lifesaving benefits of emergency tourniquets to stop bleeding in major limb trauma. Morbidity associated with tourniquet use was minor. Study Objectives: The objective of this study is to further analyze emergency tourniquet use in combat casualty care. Design and Setting: This report is a continuation of our previous study of tourniquet use in casualties admitted to a combat support hospital (NCT00517166 at www.ClinicalTrials.gov). Methods: After verifying comparable methodologies for the first study and the current study, we compared patient results for these two time periods and then pooled data to analyze outcomes with a larger sample size. Results: The total study population was 499 (232 in the previous study and 267 in the current study). In all, 862 tourniquets were applied on 651 limbs. Survival was 87% for both study periods. Morbidity rates for palsies at the level of the tourniquet were 1.7% for study 1 and 1.5% for study 2; major limb shortening was 0.4% for both. Survival was associated with prehospital application (89% vs. 78% hospital, p < 0.01) and application before the onset of shock (96% vs. 4% after). Conclusions: This study shows consistent lifesaving benefits and low risk of emergency tourniquets to stop bleeding in major limb trauma. Published by Elsevier Inc. C1 [Kragh, John F., Jr.] USA, Bone & Soft Tissue Trauma Res Program, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Littrel, Michelle L.; Holcomb, John B.] Brooke Army Med Ctr, Dept Nursing, Ft Sam Houston, TX 78234 USA. RP Kragh, JF (reprint author), USA, Bone & Soft Tissue Trauma Res Program, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611,Room L82-, Ft Sam Houston, TX 78234 USA. NR 44 TC 85 Z9 85 U1 0 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD DEC PY 2011 VL 41 IS 6 BP 590 EP 597 DI 10.1016/j.jemermed.2009.07.022 PG 8 WC Emergency Medicine SC Emergency Medicine GA 869BZ UT WOS:000298572000003 PM 19717268 ER PT J AU Neiman, PJ Schick, LJ Ralph, FM Hughes, M Wick, GA AF Neiman, Paul J. Schick, Lawrence J. Ralph, F. Martin Hughes, Mimi Wick, Gary A. TI Flooding in Western Washington: The Connection to Atmospheric Rivers SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID AMERICAN REGIONAL REANALYSIS; UNITED-STATES; WATER-VAPOR; PACIFIC-NORTHWEST; TROPICAL MOISTURE; PRECIPITATION; CLIMATOLOGY; CALIFORNIA; MOUNTAINS; SATELLITE AB This study utilizes multiple decades of daily streamflow data gathered in four major watersheds in western Washington to determine the meteorological conditions most likely to cause flooding in those watersheds. Two are located in the Olympic Mountains and the other two in the western Cascades; and each has uniquely different topographic characteristics. The flood analysis is based on the maximum daily flow observed during each water year (WY) at each site [i.e., the annual peak daily flow (APDF)], with an initial emphasis on the 12 most recent water years between WY1998 and 2009, and then focusing on a 30-year interval between WY 1980 and 2009. The shorter time period coincides with relatively complete passive microwave satellite coverage of integrated water vapor (IWV) over the Pacific basin. The combination of IWV imagery and streamflow data highlights a close link between landfalling atmospheric rivers (ARs) and APDFs (i.e., 46 of the 48 APDFs occurred with landfalling ARs). To complement this approach, the three-decade time series of APDFs, which correspond to the availability of the North American Regional Reanalysis (NARR) dataset, are examined. The APDFs occur most often, and are typically largest in magnitude, from November to January. The NARR is used to assess the composite meteorological conditions associated with the 10 largest APDFs at each site during this 30-year period. Heavy precipitation fell during the top 10 APDFs, and anomalously high composite NARR melting levels averaged similar to 1.9 km MSL, which is primarily above the four basins of interest. Hence, on average, mostly rain rather than snow fell within these basins, leading to enhanced runoff. The flooding on the four watersheds shared common meteorological attributes, including the presence of landfalling ARs with anomalous warmth, strong low-level water vapor fluxes, and weak static stability. There were also key differences that modulated the orographic control of precipitation. Notably, two watersheds experienced their top 10 APDFs when the low-level flow was southwesterly, while the other two basins had their largest APDFs with west southwesterly flow. These differences arose because of the region's complex topography, basin orientations, and related rain shadowing. C1 [Neiman, Paul J.; Ralph, F. Martin] NOAA, ESRL, Div Phys Sci, Boulder, CO 80305 USA. [Schick, Lawrence J.] US Army Corps Engn, Seattle, WA USA. [Hughes, Mimi] Univ Colorado, NOAA, Cooperat Inst Res Environm Sci, Boulder, CO 80309 USA. RP Neiman, PJ (reprint author), NOAA, ESRL, Div Phys Sci, 325 Broadway, Boulder, CO 80305 USA. EM Paul.J.Neiman@noaa.gov RI Hughes, Mimi/C-3710-2009 OI Hughes, Mimi/0000-0002-4554-9289 NR 41 TC 101 Z9 102 U1 5 U2 37 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X EI 1525-7541 J9 J HYDROMETEOROL JI J. Hydrometeorol. PD DEC PY 2011 VL 12 IS 6 BP 1337 EP 1358 DI 10.1175/2011JHM1358.1 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 864CU UT WOS:000298215400011 ER PT J AU Sheehy, S Duncan, C Anagnostou, N Elias, S Halstead, F Collins, K Ewer, K Edwards, N Douglas, A Gantlett, K Lawrie, A Berrie, E Moyles, S Long, C Sinden, R Blagborough, A Murphy, J Nicosia, A Hill, A Draper, S AF Sheehy, Susanne Duncan, Christopher Anagnostou, Nicholas Elias, Sean Halstead, Fenella Collins, Katharine Ewer, Katie Edwards, Nick Douglas, Alexander Gantlett, Katherine Lawrie, Alison Berrie, Eleanor Moyles, Sarah Long, Carole Sinden, Robert Blagborough, Andrew Murphy, Jittawadee Nicosia, Alfredo Hill, Adrian Draper, Simon TI CLINICAL EVALUATION OF NEW VIRAL VECTORED VACCINES TARGETING THE PLASMODIUM FALCIPARUM BLOOD-STAGE ANTIGENS; MSP1 AND AMA1 SO JOURNAL OF INFECTION LA English DT Meeting Abstract C1 [Sheehy, Susanne; Duncan, Christopher; Anagnostou, Nicholas; Elias, Sean; Halstead, Fenella; Collins, Katharine; Ewer, Katie; Edwards, Nick; Douglas, Alexander; Gantlett, Katherine; Lawrie, Alison; Berrie, Eleanor; Moyles, Sarah; Hill, Adrian; Draper, Simon] Univ Oxford, Oxford, England. [Long, Carole] NIAID, NIH, Rockville, MD USA. [Sinden, Robert; Blagborough, Andrew] Univ London Imperial Coll Sci Technol & Med, London, England. [Murphy, Jittawadee] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nicosia, Alfredo] Okairos, Rome, Italy. NR 0 TC 0 Z9 0 U1 0 U2 3 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 J9 J INFECTION JI J. Infect. PD DEC PY 2011 VL 63 IS 6 BP 492 EP 493 PG 3 WC Infectious Diseases SC Infectious Diseases GA 869GP UT WOS:000298586100207 ER PT J AU Russell, K Reinhardt, L AF Russell, Kevin Reinhardt, Lyonel TI Experimental Primer Seating-Stamping Tool Study in Small Caliber Cartridge Production SO JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article DE metal stamping; stamping tool design; stamping experiments; modeling and simulation ID SIMULATION AB In an effort to produce a more secure assembly fit between the primer and the cartridge case in 5.56 mm combat ammunition, variants of the conventional case stamping tool were developed and incorporated in the small caliber ammunition manufacturing process (or SCAMP). The challenge is to develop a tool that provides a secure cartridge case-primer assembly fit while maximizing tool life. Two concept tool designs were realized-a concept four-prong triangular stamping tool and a concept four-prong wave stamping tool. This work compares the results of SCAMP trials using a concept four-prong triangular stamping tool, a concept four-prong wave stamping tool and the conventional circular stamping tool. Comparison data include cartridge case material movement after stamping, stamping tool stress distribution, stamping tool life, and stamping forces required to achieve the objective primer seating depths. Although the SCAMP trials are still ongoing, the findings to date show that the wave stamping tool has consistently met the design challenges of improved cartridge case-primer assembly fit and maximized tool life and is currently the leading candidate for implementation in SCAMP. C1 [Russell, Kevin; Reinhardt, Lyonel] USA, Armaments Engn & Technol Ctr, Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. RP Russell, K (reprint author), USA, Armaments Engn & Technol Ctr, Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM kevin.russell1@us.army.mil; lyonel.reinhardt@us.army.mil NR 6 TC 1 Z9 1 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1087-1357 J9 J MANUF SCI E-T ASME JI J. Manuf. Sci. Eng.-Trans. ASME PD DEC PY 2011 VL 133 IS 6 AR 064504 DI 10.1115/1.4005312 PG 6 WC Engineering, Manufacturing; Engineering, Mechanical SC Engineering GA 868RQ UT WOS:000298542600035 ER PT J AU Livezey, J Perez, L Suciu, D Yu, X Robinson, B Bush, D Merrill, G AF Livezey, Jeffrey Perez, Luis Suciu, Dominic Yu, Xin Robinson, Brian Bush, David Merrill, Gerald TI Analysis of group A streptococcus gene expression in humans with pharyngitis using a microarray SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID CYNOMOLGUS MACAQUES; EPITHELIAL-CELLS; GENOME SEQUENCE; IRON TRANSPORT; PYOGENES; VIRULENCE; TRANSCRIPTOME; STRAINS; INFECTION; GROWTH AB Pharyngitis caused by group A streptococci (GAS) is one of the most common infections around the world. However, relatively little is known about which genes are expressed and which genes regulate expression during acute infection. Due to their ability to provide genome-wide views of gene expression at one time, microarrays are increasingly being incorporated in GAS research. In this study, a novel electrochemical detection-based microarray was used to identify gene expression patterns among humans with culture-confirmed GAS pharyngitis. Using 14 samples (11 GAS-positive and three GAS-negative) obtained from subjects seen at the Brooke Army Medical Center paediatric clinic, this study demonstrated two different clusters of gene expression patterns. One cluster expressed a larger number of genes related to phages, immune-system evasion and survival among competing oral flora, signifying a potentially more virulent pattern of gene expression. The other cluster showed a greater number of genes related to nutrient acquisition and protein expression. This in vivo genome-wide analysis of GAS gene expression in humans with pharyngitis evaluated global gene expression in terms of virulence factors. C1 [Livezey, Jeffrey; Perez, Luis; Suciu, Dominic; Yu, Xin; Robinson, Brian; Bush, David; Merrill, Gerald] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Livezey, J (reprint author), Brooke Army Med Ctr, Dept Clin Invest, 3400 Rawley E Chambers Ave,Suite A, Ft Sam Houston, TX 78234 USA. EM Jeffrey.livezey@us.army.mil NR 42 TC 3 Z9 3 U1 0 U2 5 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD DEC PY 2011 VL 60 IS 12 BP 1725 EP 1733 DI 10.1099/jmm.0.022939-0 PG 9 WC Microbiology SC Microbiology GA 864DV UT WOS:000298218100002 PM 21799202 ER PT J AU Johnson, SM Grace, N Edwards, MJ Woo, R Puapong, D AF Johnson, Sidney M. Grace, Nalani Edwards, Mary J. Woo, Russell Puapong, Devin TI Thoracoscopic segmentectomy for treatment of congenital lung malformations SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 44th Annual Meeting of the Pacific-Association-of-Pediatric-Surgeons CY APR 10-14, 2011 CL Cancun, MEXICO SP Pacific Assoc Pediat Surg DE CCAM; Congenital cystic lung; Thoracoscopy; Segmental; Sequestration ID CYSTIC ADENOMATOID MALFORMATION; PLEUROPULMONARY BLASTOMA; MANAGEMENT; SURGERY; LESIONS; EXPERIENCE; LOBECTOMY; RESECTION AB Purpose: Congenital lung malformations (CLM) predispose patients to recurrent respiratory tract infections and pose a rare risk of malignant transformation. Although pulmonary lobectomy is the most common treatment of a CLM, some advocate segmental resection as a lung preservation strategy. Our study evaluated lung-preserving thoracoscopic segmentectomy as an alternative to lobectomy for CLM resection. Methods: We conducted a retrospective review of patients who underwent thoracoscopic segmentectomy for CLM from 2007 to 2010. Results: Fifteen patients underwent thoracoscopic segmentectomy for CLM. There were five postoperative complications: three asymptomatic pneumothoraces and a small air leak that resolved without intervention. One patient developed a bronchopulmonary fistula requiring thoracoscopic repair. At follow-up, all patients are asymptomatic. One patient has a small amount of residual disease on postoperative computed tomography (CT), and re-resection has been recommended. Conclusions: Thoracoscopic segmentectomy for CLM is a safe and effective means of lung parenchymal preservation. The approach spares larger airway anatomy and has a complication rate that is comparable with that of thoracoscopic lobectomy. Residual disease can often only be appreciated on postoperative CT scan and may require long-term follow-up or reoperation in rare cases. This lung preservation technique is best suited to smaller lesions. (C) 2011 Elsevier Inc. All rights reserved. C1 [Johnson, Sidney M.; Woo, Russell; Puapong, Devin] Kapiolani Med Ctr Women & Children, Honolulu, HI USA. [Grace, Nalani] UC Davis Med Ctr, Sacramento, CA USA. [Edwards, Mary J.] Tripler Army Med Ctr, Tamc, HI USA. RP Johnson, SM (reprint author), Kapiolani Med Ctr Women & Children, Honolulu, HI USA. EM Sidney.Johnson@kapiolani.org NR 28 TC 15 Z9 16 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD DEC PY 2011 VL 46 IS 12 BP 2265 EP 2269 DI 10.1016/j.jpedsurg.2011.09.012 PG 5 WC Pediatrics; Surgery SC Pediatrics; Surgery GA 863FT UT WOS:000298148900018 PM 22152862 ER PT J AU Klein, TA Kang, HJ Gu, SH Moon, S Shim, SH Park, YM Lee, SY Kim, HC Chong, ST O'Guinn, M Lee, JS Turell, MJ Song, JW AF Klein, Terry A. Kang, Hae Ji Gu, Se Hun Moon, Sungsil Shim, So-Hee Park, Yon Mi Lee, Sook-Young Kim, Heung-Chul Chong, Sung-Tae O'Guinn, Monica Lee, John S. Turell, Michael J. Song, Jin-Won TI Hantaan virus surveillance targeting small mammals at Dagmar North Training Area, Gyeonggi Province, Republic of Korea, 2001-2005 SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE Hantavirus; Apodemus agrarius; Microtus fortis; Mus musculus; military; phylogeny; epidemiology; ecology ID ETIOLOGIC AGENT; ECOLOGICAL SURVEILLANCE; NEPHROPATHIA-EPIDEMICA; GENETIC DIVERSITY; APODEMUS-AGRARIUS; HEMORRHAGIC-FEVER; PUUMALA VIRUS; HANTAVIRUS; TRANSMISSION; PREVALENCE AB In response to a hemorrhagic fever with renal syndrome case in November 2000, a seasonal rodent-borne disease surveillance program was initiated at Dagmar North Training Area (DNTA), Gyeonggi Province, Republic of Korea. From April 2001-December 2005, 1,848 small mammals were captured. Apodemus agrarius accounted for 92.5%, followed by Mus musculus (3.6%), Crocidura lasiura (2.1%), and Microtus fortis (1.1%). Three species of rodents were found to be antibody-positive (Ab+) for Hantaan virus (HTNV): A. agrarius (22.3%), M. musculus (9.1%), and M. fortis (5.0%). Ab+ rates for A. agrarius increased with increasing weight (age), except for those weighing <10 g. The peak HTNV transmission period in Korea coincided with the peak reproductive potential of A. agrarius during the fall (August/September) surveys. HTNV strains from DNTA were distinct from HTNV strains from the People's Republic of China. From these studies, more accurate risk assessments can be developed to better protect personnel from rodent-borne diseases. C1 [Kang, Hae Ji; Gu, Se Hun; Moon, Sungsil; Shim, So-Hee; Park, Yon Mi; Lee, Sook-Young; Song, Jin-Won] Korea Univ, Inst Viral Dis, Coll Med, Dept Microbiol, Seoul 136705, South Korea. [Klein, Terry A.] USA, MEDDAC Korea, Unit 15281, APO, AP 96205 USA. [Kim, Heung-Chul; Chong, Sung-Tae] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, APO, AP 96205 USA. [O'Guinn, Monica; Lee, John S.; Turell, Michael J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Song, JW (reprint author), Korea Univ, Inst Viral Dis, Coll Med, Dept Microbiol, 126-1,5 Ga, Seoul 136705, South Korea. EM jwsong@korea.ac.kr RI Valle, Ruben/A-7512-2013 FU BAAHC, U.S. Army MEDDAC-Korea; Division of Global Emerging Infections Surveillance and Response System (GEIS) Operations; Armed Forces Health Surveillance Center, Silver Spring, MD; National Center of Medical Intelligence, Fort Detrick, MD FX We thank COL Brian Allgood (deceased, and for whom the Brian Allgood Army Community Hospital (BAACH) was recently named) and Hee-Choon (Sam) Lee for their support. We thank Suk Hee Yi, Force Health Protection and Preventive Medicine, 65th Medical Brigade, for analysis of data and GIS mapping; Jiun Yoon and Amy Nguyen, attending physicians, BAAHC, and Rex Bergren, Chief, Laboratory Services, BAAHC, U.S. Army MEDDAC-Korea, for their support; and K. Kenyon, USAMRIID, for her editorial suggestions. Funding for portions of this work was provided by the Division of Global Emerging Infections Surveillance and Response System (GEIS) Operations, Armed Forces Health Surveillance Center, Silver Spring, MD, and the National Center of Medical Intelligence, Fort Detrick, MD. The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of Defense, the Department of the Army, or the U.S. Government. NR 26 TC 10 Z9 10 U1 0 U2 5 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD DEC PY 2011 VL 36 IS 2 BP 373 EP 381 DI 10.1111/j.1948-7134.2011.00178.x PG 9 WC Entomology SC Entomology GA 861KL UT WOS:000298017700016 PM 22129409 ER PT J AU Cote, CK Welkos, SL Bozue, J AF Cote, Christopher K. Welkos, Susan L. Bozue, Joel TI Key aspects of the molecular and cellular basis of inhalational anthrax SO MICROBES AND INFECTION LA English DT Review DE Bacillus anthracis; Spores; Inhalational anthrax; Germination; Phagocytes ID VIRULENT BACILLUS-ANTHRACIS; LETHAL TOXIN; SPORE GERMINATION; DENDRITIC CELLS; ALVEOLAR MACROPHAGES; IN-VIVO; ENDOSPORES REQUIRES; EPITHELIAL-CELLS; STERNE STRAIN; MOUSE MODEL AB Bacillus anthracis is the etiologic agent of the disease inhalational anthrax, an acute systemic infection initiated by inhaling spores, which if not rapidly detected and treated, results in death. Decades of research have elucidated novel aspects of anthrax pathogenesis but there are many issues left unresolved. Published by Elsevier Masson SAS on behalf of Institut Pasteur. C1 [Cote, Christopher K.; Welkos, Susan L.; Bozue, Joel] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. RP Cote, CK (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Frederick, MD 21702 USA. EM christopher.cote2@us.army.mil NR 90 TC 20 Z9 22 U1 2 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1286-4579 J9 MICROBES INFECT JI Microbes Infect. PD DEC PY 2011 VL 13 IS 14-15 BP 1146 EP 1155 DI 10.1016/j.micinf.2011.07.005 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 862XQ UT WOS:000298127800003 PM 21816231 ER PT J AU Jones, WS Yun, HC AF Jones, Woodson S. Yun, Heather C. TI Air Force Academic Medicine: A Climate Survey SO MILITARY MEDICINE LA English DT Article ID SATISFACTION; FACULTY; PERCEPTIONS; PHYSICIANS; CARE AB Air Force (AF) Medical Service leadership considers education, training, and research as key priorities. However, AF academic physicians' perceptions about the academic environment and challenges to success are not well described. AF faculty physicians were surveyed in autumn 2009. One hundred seventy-two responded and rated the academic environment as needing improvement (median Likert-like score 2 [interquartile range 1] on 1-5 scale). The impact of stepping away from an academically oriented career path for other executive positions was rated negatively (median Likert-like score 2, interquartile range 1). Concerns included loss of clinical skills, career disruption, and the challenge of returning to and/or competing for positions within the academic pathway. New policies limiting deployment of Program Directors and/or key teaching faculty were viewed favorably. Most physicians (59%) completing this survey expressed concerns about the AF academic environment and identified numerous challenges. Information from this survey can guide future initiatives to enhance leadership's goals. C1 [Jones, Woodson S.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. [Yun, Heather C.] Brooke Army Med Ctr, Infect Dis Serv MCHE MDI, Ft Sam Houston, TX 78234 USA. RP Jones, WS (reprint author), Wilford Hall USAF Med Ctr, 59th Med Wing,2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. NR 15 TC 0 Z9 0 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2011 VL 176 IS 12 BP 1388 EP 1394 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 861OK UT WOS:000298028900007 PM 22338353 ER PT J AU Childers, R Tolentino, JC Leasiolagi, J Wiley, N Liebhardt, D Barbabella, S Kragh, JF AF Childers, Richard Tolentino, Jerlyn C. Leasiolagi, John Wiley, Nick Liebhardt, Damian Barbabella, Sean Kragh, John F., Jr. TI Tourniquets Exposed to the Afghanistan Combat Environment Have Decreased Efficacy and Increased Breakage Compared to Unexposed Tourniquets SO MILITARY MEDICINE LA English DT Article ID INFLATION PRESSURES; CUFFS; FLOW AB We hypothesize that an anecdotally observed increase in tourniquet breakage and decrease in efficacy may be secondary to environmental exposure during military deployment. This was a study comparing efficacy and breakage of 166 Afghanistan-exposed tourniquets to 166 unexposed tourniquets. Afghanistan exposure was defined as tourniquet carriage by field staff in the operational environment for approximately 6 months. In a controlled environment in the United States, a previously exposed tourniquet was tested on one thigh of each subject, while an unexposed tourniquet was tested on the opposite thigh. We recorded tourniquet efficacy (absence of distal pedal pulse for at least 30 seconds), breakage, and the number of turns required to stop the distal pedal pulse. A Wilcoxon sign-rank test was used to test differences between exposed and unexposed tourniquets. Tourniquets exposed to the environment broke more often (14/166 versus 0/166) and had decreased efficacy (63% versus 91%; p <0.001). Three turns were required for most tourniquets to be efficacious. Environmental exposure of military tourniquets is associated with decreased efficacy and increased breakage. In most cases, tourniquets require three turns to stop the distal lower extremity pulse. C1 [Childers, Richard; Tolentino, Jerlyn C.] Naval Hosp Camp Pendleton, Oceanside, CA 92058 USA. [Leasiolagi, John] 2nd Reconnaissance Battal, Marine Div 2, Camp Lejeune, NC 28542 USA. [Wiley, Nick] Force Reconnaissance Co, Marine Expeditionary Force 2, Camp Lejeune, NC 28542 USA. [Liebhardt, Damian] USN, San Diego Med Ctr, San Diego, CA 92134 USA. [Barbabella, Sean] USN, Med Ctr Portsmouth, Portsmouth, VA 23708 USA. [Kragh, John F., Jr.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Childers, R (reprint author), Naval Hosp Camp Pendleton, H100 Santa Margarita Rd, Oceanside, CA 92058 USA. NR 15 TC 6 Z9 7 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2011 VL 176 IS 12 BP 1400 EP 1403 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 861OK UT WOS:000298028900009 PM 22338355 ER PT J AU Wilson, C McClung, JP Karl, JP Brothers, MD AF Wilson, Candy McClung, James P. Karl, J. Philip Brothers, Michael D. TI Iron Status of Military Personnel Deployed to Afghanistan SO MILITARY MEDICINE LA English DT Article ID PLACEBO-CONTROLLED TRIAL; FEMALE SOLDIERS; DEFICIENCY ANEMIA; DOUBLE-BLIND; MOOD; PREVALENCE; DECREMENTS; STRESS; IMPACT; WOMEN AB Iron is a micronutrient necessary for energy metabolism and for oxygen transport and delivery. Depletion of iron stores (iron deficiency [ID]) may lead to iron deficiency anemia (IDA), which affects mood, cognitive function, and physical performance. Previous studies indicated that iron status may decline during military training. This study assessed the iron status and prevalence of ID and IDA in military personnel deployed to Bagram Air Base, Afghanistan (1492 m). Within the pool of 294 participants (149 male and 145 female), 2 males (1%) and 8 females (6%) presented with ID. Although IDA was not observed in males, 3 females (2%) met the criteria for IDA. Female sex (p = 0.05) and self-reported history of anemia (p < 0.05) were associated with diminished iron status. Amenorrhea was associated with higher ferritin (p < 0.05) and hemoglobin (p < 0.05) levels. Although ID and IDA did not affect a large portion of the deployed population assessed in this study, findings suggest that risk factors including female sex, history of anemia, and regular menstruation should be considered in the assessment of iron status in military personnel. C1 [Wilson, Candy] Wilford Hall USAF Med Ctr, CSPG Clin Res Div 59, Lackland AFB, TX 78236 USA. [McClung, James P.; Karl, J. Philip] USA, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA. [Brothers, Michael D.] USAF Acad, Dept Biol, Colorado Springs, CO 80840 USA. RP Wilson, C (reprint author), Wilford Hall USAF Med Ctr, CSPG Clin Res Div 59, 2200 Bergquist Dr, Lackland AFB, TX 78236 USA. RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 FU Tr-Service Nursing Research Program [N10-P20]; U.S. Air Force Surgeon General FX We thank the Joint Combat Casualty Research Team (Team 7) for their assistance with the execution of this study. We also thank Lorraine Sobson for her editorial expertise. Funding for this project was provided by the Tr-Service Nursing Research Program (N10-P20) and by the U.S. Air Force Surgeon General. NR 20 TC 3 Z9 3 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2011 VL 176 IS 12 BP 1421 EP 1425 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 861OK UT WOS:000298028900013 PM 22338359 ER PT J AU Willis, PF Farrer, TJ Bigler, ED AF Willis, Pamelia F. Farrer, Thomas J. Bigler, Erin D. TI Are Effort Measures Sensitive to Cognitive Impairment? SO MILITARY MEDICINE LA English DT Article ID WORD MEMORY TEST; TRAUMATIC BRAIN-INJURY; SYMPTOM VALIDITY TEST; CARD SORTING TEST; NEUROPSYCHOLOGICAL ASSESSMENT; AMERICAN-ACADEMY; TEST-PERFORMANCE; RETENTION TRIAL; SCORES; DAMAGE AB The basic premise of symptom validity tests (SVTs) is that appropriate effort can be assessed because the designs of SVT measures are thought to be insensitive to all but the most extreme forms of impairment of memory. In patients with mild traumatic brain injury in particular, it is thought that failure on effort measures consistently reflects poor effort or even conscious exaggeration of symptoms. This study examines the issue of SVT failure as a reflection of cognitive impairment and/or neuropsychiatric impairment by presenting cases of three patients who were given full neuropsychological batteries but in each case failed the Word Memory Test (WMT), a verbal recognition SVT measure. One patient who failed the WMT was probably in the early stages of dementia. The WMT fit the "Genuine Memory Impaired Profile". Two mild traumatic brain injury patients failed the WMT but their patterns of performance suggested that cognitive deficits influenced WMT performance. In determining the validity of neuropsychological test data in the individual case, it is recommended that the examiner consider whether cognitive impairment could affect performance on effort measures and the recommended cut score. Also, it is recommended that examiners use multiple indicators of effort. C1 [Willis, Pamelia F.] Brooke Army Med Ctr, Dept Behav Med, ATTN MCHE BM, Ft Sam Houston, TX 78234 USA. [Farrer, Thomas J.; Bigler, Erin D.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA. RP Willis, PF (reprint author), Brooke Army Med Ctr, Dept Behav Med, ATTN MCHE BM, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 31 TC 11 Z9 11 U1 1 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2011 VL 176 IS 12 BP 1426 EP 1431 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 861OK UT WOS:000298028900014 PM 22338360 ER PT J AU Vanfosson, CA Seery, JM AF Vanfosson, Christopher A. Seery, Jason M. TI Simultaneous Surgeries in a Split Forward Surgical Team: A Case Study SO MILITARY MEDICINE LA English DT Article AB Introduction: The 541St Forward Surgical Team performed split-based operations, with one site in the city of Pol-e-Khumri. One evening, the 10-person team received two pediatric patients simultaneously and conducted simultaneous surgeries. Case presentation: The 3-year-old female sustained severe injuries to bilateral lower extremities and a puncture wound to her right forearm. The 13-year-old sustained fragmentary wounds to her left hand, left foot, right medial calf, and evisceration to her left lower quadrant. The patients presented in extremis after being taken to a civilian hospital initially, spending approximately 1.5 hours receiving no resuscitative therapy. The 3-year-old underwent amputations of bilateral lower extremities and a fasciotomy of the right forearm. The 13-year-old survived an exploratory laparotomy and irrigation and debridement of intra-abdominal wounds. Conclusion: The successful completion of simultaneous surgeries, by a split forward surgical team at a remote location, for two critically ill patients is possible. It should not become the standard of care. Prior planning made this occurrence feasible and safer, but such situations put the patients at risk for complications. C1 [Vanfosson, Christopher A.; Seery, Jason M.] Forward Surg Airborne, Med Detachment 541, Ft Bragg, NC 28310 USA. RP Vanfosson, CA (reprint author), Forward Surg Airborne, Med Detachment 541, 44th Med Brigade,Bldg A-6634 Gorham St, Ft Bragg, NC 28310 USA. NR 3 TC 2 Z9 2 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 2011 VL 176 IS 12 BP 1447 EP 1449 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 861OK UT WOS:000298028900018 PM 22338364 ER PT J AU Linkov, I Bates, ME Canis, LJ Seager, TP Keisler, JM AF Linkov, Igor Bates, Matthew E. Canis, Laure J. Seager, Thomas P. Keisler, Jeffrey M. TI A decision-directed approach for prioritizing research into the impact of nanomaterials on the environment and human health SO NATURE NANOTECHNOLOGY LA English DT Article ID CARBON NANOTUBE PROCESSES; INFORMATION AB The emergence of nanotechnology has coincided with an increased recognition of the need for new approaches to understand and manage the impact of emerging technologies on the environment and human health. Important elements in these new approaches include life-cycle thinking, public participation and adaptive management of the risks associated with emerging technologies and new materials(1). However, there is a clear need to develop a framework for linking research on the risks associated with nanotechnology to the decision-making needs of manufacturers, regulators, consumers and other stake-holder groups(2,3). Given the very high uncertainties associated with nanomaterials and their impact on the environment and human health, research resources should be directed towards creating the knowledge that is most meaningful to these groups. Here, we present a model ( based on multicriteria decision analysis and a value of information approach) for prioritizing research strategies in a way that is responsive to the recommendations of recent reports on the management of the risk(4,5) and impact of nanomaterials on the environment and human health(6). C1 [Linkov, Igor; Bates, Matthew E.; Canis, Laure J.] US Army Corps Engineers, US Army Engn Res & Dev Ctr, Concord, MA 01742 USA. [Seager, Thomas P.] Arizona State Univ, Global Inst Sustainabil, Tempe, AZ 85287 USA. [Seager, Thomas P.] Arizona State Univ, Sch Sustainable Engn & Build Environm, Tempe, AZ 85287 USA. [Keisler, Jeffrey M.] Univ Massachusetts, Coll Management, Dept Management Sci & Informat Syst, Boston, MA 02125 USA. RP Linkov, I (reprint author), US Army Corps Engineers, US Army Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM igor.linkov@usace.army.mil FU US Army Engineer Research and Development Center FX This work was supported by the Environmental Quality Research Program of the US Army Engineer Research and Development Center. The authors thank E. Ferguson, the manager of this programme. J. Steevens and M. Chappell of the US Army Corps of Engineers are thanked for their editorial comments and suggestions. Permission was granted by the Chief of Engineers to publish this information. NR 21 TC 34 Z9 39 U1 2 U2 20 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1748-3387 J9 NAT NANOTECHNOL JI Nat. Nanotechnol. PD DEC PY 2011 VL 6 IS 12 BP 784 EP 787 DI 10.1038/NNANO.2011.163 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 864OA UT WOS:000298248300010 PM 21963715 ER PT J AU Eichinger, JK Beingessner, D AF Eichinger, Josef K. Beingessner, Daphne TI Intraoperative Fabrication of Bone Tamps for Indirect Reduction of Depressed Articular Segments SO ORTHOPEDICS LA English DT Editorial Material AB The use of bone tamps for indirect reduction of depressed articular segments is an established method of treatment for intra-articular fractures in a variety of joint injuries. Customized bone tamps can be fabricated intraoperatively using commonly available instruments and supplies consisting of Steinmann pins and T-handled chucks. The technique combines the use of bone tamps through carefully created metaphyseal windows, fluoroscopic guidance, packing with cancellous bone, and adequate fixation. This treatment methodology can allow for a minimally invasive or soft tissue preserving approach for the treatment of some intra-articular fractures while achieving anatomic reduction of the joint surface. C1 [Eichinger, Josef K.] Womack Army Med Ctr, Dept Orthopaed, Ft Bragg, NC 28307 USA. [Beingessner, Daphne] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA. RP Eichinger, JK (reprint author), Womack Army Med Ctr, Dept Orthopaed, 2817 Reilly Rd, Ft Bragg, NC 28307 USA. EM joe.eichinger@gmail.com NR 3 TC 1 Z9 1 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD DEC PY 2011 VL 34 IS 12 BP 970 EP 974 DI 10.3928/01477447-20111021-19 PG 5 WC Orthopedics SC Orthopedics GA 864AJ UT WOS:000298209100019 PM 22147212 ER PT J AU Damasco, CVC Dire, DJ AF Damasco, Cpt Veronica C. Dire, Daniel J. TI A Child With Leukocoria SO PEDIATRIC EMERGENCY CARE LA English DT Article DE leukocoria; retinoblastoma; pupil ID RETINOBLASTOMA; EYE AB Leukocoria, meaning "white pupil," describes the clinical finding of a white pupillary reflex on examination. It may be discovered through an asymmetric red reflex using direct ophthalmoscopy, or it may be seen incidentally on flash photography. It results from an abnormality of the eyeball that interferes with the normal reflective process. We report a case of a 3-year-old boy who presents with leukocoria found to be caused by a retinoblastoma and discuss the differential diagnosis of this uncommon presentation to the pediatric emergency department. C1 [Dire, Daniel J.] Univ Texas Hlth Sci Ctr San Antonio, Div Pediat Emergency Med, Dept Pediat, San Antonio, TX 78229 USA. [Damasco, Cpt Veronica C.] USA, San Antonio Uniformed Serv Hlth Educ Consortium P, Med Corps, San Antonio, TX USA. RP Dire, DJ (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Div Pediat Emergency Med, Dept Pediat, San Antonio, TX 78229 USA. EM dire@uthscsa.edu NR 26 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0749-5161 J9 PEDIATR EMERG CARE JI Pediatr. Emerg. Care PD DEC PY 2011 VL 27 IS 12 BP 1170 EP 1174 DI 10.1097/PEC.0b013e31823b0316 PG 5 WC Emergency Medicine; Pediatrics SC Emergency Medicine; Pediatrics GA 863EY UT WOS:000298146800015 ER PT J AU McDonald, BA AF McDonald, Brian A. TI Study of the Effects of Aging under Humidity Control on the Thermal Decomposition of NC/NG/BTTN/RDX Propellants SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Nitrate Esters; Propellants; Stabilizers; Aging ID CONSECUTIVE PRODUCTS; STABILIZER; RDX AB The effects of aging under controlled humidity on the thermal decomposition of two nitrate ester/RDX propellants are examined. Propellant samples are artificially aged at 60 degrees C and 70 degrees C at various levels of relative humidity. Differential scanning calorimetry is used to study the post aged samples to determine the activation energy of the peak exotherm and peak temperature of these events. For each humidity level, differential scanning calorimetry is conducted on an aged and an unaged sample that is conditioned to the humidity of the environment to distinguish between aging effects and residual moisture effects. Nitrate ester stabilizer depletions rates are presented as a function of aging and humidity. The results of the study show that moisture level during aging irreversibly alters the activation energy of the primary heat release events and significantly influences the stabilizer depletion rates. C1 USA, Weap Integrat & Dev Directorate WDI, Aviat & Missile RDE Ctr AMRDEC, Redstone Arsenal, AL 35898 USA. RP McDonald, BA (reprint author), USA, Weap Integrat & Dev Directorate WDI, Aviat & Missile RDE Ctr AMRDEC, Redstone Arsenal, AL 35898 USA. EM brian.mcdonald8@us.army.mil RI McDonald, Brian/D-5267-2017 OI McDonald, Brian/0000-0002-5390-5132 NR 24 TC 5 Z9 6 U1 4 U2 23 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD DEC PY 2011 VL 36 IS 6 BP 576 EP 583 DI 10.1002/prep.200900094 PG 8 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 866OW UT WOS:000298391600013 ER PT J AU Simone, CB Ly, D Dan, TD Ondos, J Ning, H Belard, A O'Connell, J Miller, RW Simone, NL AF Simone, Charles B., II Ly, David Dan, Tu D. Ondos, John Ning, Holly Belard, Arnaud O'Connell, John Miller, Robert W. Simone, Nicole L. TI Comparison of intensity-modulated radiotherapy, adaptive radiotherapy proton radiotherapy, and adaptive proton radiotherapy for treatment of locally advanced head and neck cancer SO RADIOTHERAPY AND ONCOLOGY LA English DT Article DE Head and neck cancer; Proton therapy; Adaptive radiotherapy; IMRT; Treatment planning ID RADIATION-THERAPY; GEOMETRIC CHANGES; PAROTID-GLAND; LUNG-CANCER; CARCINOMA; PHOTON; TUMORS; IMRT; OROPHARYNX; SHRINKAGE AB Background and purpose: Various radiotherapy planning methods for locally advanced squamous cell carcinoma of the head and neck (SCCHN) have been proposed to decrease normal tissue toxicity. We compare IMRT, adaptive IMRT, proton therapy (IMPT), and adaptive IMPT for SCCHN. Materials and methods: Initial and re-simulation CT images from 10 consecutive patients with SCCHN were used to quantify dosimetric differences between photon and proton therapy. Contouring was performed on both CTs, and plans (n = 40 plans) and dose-volume histograms were generated. Results: The mean GTV volume decreased 53.4% with re-simulation. All plans provided comparable PTV coverage. Compared with IMRT, adaptive IMRT significantly reduced the maximum dose to the mandible (p = 0.020) and mean doses to the contralateral parotid gland (p = 0.049) and larynx (p = 0.049). Compared with IMRT and adaptive IMRT, IMPT significantly lowered the maximum doses to the spinal cord (p < 0.002 for both) and brainstem (p < 0.002 for both) and mean doses to the larynx (p < 0.002 for both) and ipsilateral (p = 0.004 IMRT, p = 0.050 adaptive) and contralateral (p < 0.002 IMRT, p = 0.010 adaptive) parotid glands. Adaptive IMPT significantly reduced doses to all critical structures compared with IMRT and adaptive IMRT and several critical structures compared with non-adaptive IMPT. Conclusions: Although adaptive IMRT reduced dose to several normal structures compared with standard IMRT, non-adaptive proton therapy had a more favorable dosimetric profile than IMRT or adaptive IMRT and may obviate the need for adaptive planning. Protons allowed significant sparing of the spinal cord, parotid glands, larynx, and brainstem and should be considered for SCCHN to decrease normal tissue toxicity while still providing optimal tumor coverage. Published by Elsevier Ireland Ltd. Radiotherapy and Oncology 101 (2011) 376-382 C1 [Simone, Nicole L.] NCI, NIH, Radiat Oncol Branch, Bethesda, MD 20892 USA. [Belard, Arnaud] Henry M Jackson Fdn Adv Mil Med, Washington, DC USA. [O'Connell, John] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Simone, NL (reprint author), NCI, NIH, Radiat Oncol Branch, Bldg 10-CRC,Room B2-3500,10 Ctr Dr, Bethesda, MD 20892 USA. EM simonen@mail.nih.gov OI Dan, Tu/0000-0003-1154-0507 FU U.S. Army Medical Research and Materiel Command [DAMD17-W81XWH-04-2-0022]; Roberts Proton Therapy Center at University of Pennsylvania Health System; NIH; Pfizer, Inc. FX This research was supported in part by U.S. Army Medical Research and Materiel Command under Contract Agreement No.DAMD17-W81XWH-04-2-0022, in conjunction with the Roberts Proton Therapy Center at University of Pennsylvania Health System. Research support was also through the Intramural Research Program of the NIH. D.L. was supported by the Clinical Research Training Program, a public-private partnership supported jointly by NIH and Pfizer, Inc. Opinions, interpretations, conclusions, and recommendations are those of the authors and not necessarily endorsed by the U.S. Army. NR 37 TC 49 Z9 53 U1 1 U2 6 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-8140 J9 RADIOTHER ONCOL JI Radiother. Oncol. PD DEC PY 2011 VL 101 IS 3 BP 376 EP 382 DI 10.1016/j.radonc.2011.05.028 PG 7 WC Oncology; Radiology, Nuclear Medicine & Medical Imaging SC Oncology; Radiology, Nuclear Medicine & Medical Imaging GA 873PG UT WOS:000298894700006 PM 21663988 ER PT J AU Sawyer, T Sierocka-Castaneda, A Chan, D Berg, B Lustik, M Thompson, M AF Sawyer, Taylor Sierocka-Castaneda, Agnes Chan, Debora Berg, Benjamin Lustik, Mike Thompson, Mark TI Deliberate Practice Using Simulation Improves Neonatal Resuscitation Performance SO SIMULATION IN HEALTHCARE LA English DT Article DE Neonatal resuscitation; Deliberate practice; Simulation; Positive-pressure ventilation; Umbilical catheterization ID DELIVERY-ROOM ENVIRONMENT; EXPERT PERFORMANCE; MEDICAL-EDUCATION; SKILLS; ACQUISITION; TECHNOLOGY AB Introduction: Simulation will soon become the standard method of training in the Neonatal Resuscitation Program (NRP). Deliberate practice (DP) using simulation has been shown to improve performance in other areas of medicine. The objective of this study was to evaluate the effectiveness of DP using simulation on improving NRP performance. Methods: Using a pretest-posttest design, 15 teams of 2 residents participated in a series of 3 NRP simulations followed by a facilitated debriefing. Objective measures of NRP performance and time to complete critical tasks were evaluated on the first (pretest) and the third (posttest) simulations by blinded video review using a validated scoring instrument. Results: Improvements were seen in scores for overall NRP performance (pretest 82.5% vs. posttest 92.5%, mean difference 10% [95% CI, 1.5-18.5]; P = 0.024) and positive-pressure ventilation (pretest 73.3% vs. posttest 95.0%, mean difference 21.7% [95% CI, 0.8-42.5]; P = 0.043). Time to the vascular access decreased by over 1 minute from baseline (pretest 404 second vs. posttest 343 second, mean difference -60.3 second [95% CI, -119.6 to -0.9]; P = 0.047) as did the time to first IV medication (pretest 452 second vs. posttest 387 second, mean difference -64.9 second [95% CI, -112.4 to -17.5]; P = 0.011). Conclusions: Our results suggest that DP using simulation is associated with improvements in NRP performance and support the use of DP using simulation in NRP training. (Sim Healthcare 6:327-336, 2011) C1 [Sawyer, Taylor] Tripler Army Med Ctr, MCHK PE, Dept Pediat, Honolulu, HI 96859 USA. [Sierocka-Castaneda, Agnes] Natl Naval Med Ctr, Dept Pediat, Bethesda, MD USA. [Berg, Benjamin] Univ Hawaii, Telehlth Res Inst, Honolulu, HI 96822 USA. [Lustik, Mike] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA. RP Sawyer, T (reprint author), Tripler Army Med Ctr, MCHK PE, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM taylor.l.sawyer@us.army.mil NR 28 TC 23 Z9 23 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-2332 J9 SIMUL HEALTHC JI Simul. Healthc. PD DEC PY 2011 VL 6 IS 6 BP 327 EP 336 DI 10.1097/SIH.0b013e31822b1307 PG 10 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 863IH UT WOS:000298155500003 PM 21937960 ER PT J AU Myint, KSA Gibbons, RV Iverson, J Shrestha, SK Pavlin, JA Mongkolsirichaikul, D Kosoy, MY AF Myint, Khin Saw Aye Gibbons, Robert V. Iverson, Jennifer Shrestha, Sanjaya K. Pavlin, Julie A. Mongkolsirichaikul, Duangrat Kosoy, Michael Y. TI Serological response to Bartonella species in febrile patients from Nepal SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article DE Bartonella; Febrile illness; IFA; Immune response; Nepal; Serosurvey AB The Bartonella-associated illnesses are spread world-wide and involve a broad spectrum of signs and symptoms in humans. Several Bartonella species have been shown to be responsible for cases of febrile illnesses. Little information exists on distribution of Bartonella species and their role in human diseases in Nepal. Our preliminary study, a retrospective serological survey of archived specimens, suggests that Bartonella antibodies are prevalent among febrile patients in the Kathmandu Valley of Nepal. Published by Elsevier Ltd on behalf of Royal Society of Tropical Medicine and Hygiene. C1 [Myint, Khin Saw Aye; Gibbons, Robert V.; Pavlin, Julie A.; Mongkolsirichaikul, Duangrat] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand. [Iverson, Jennifer; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA. [Shrestha, Sanjaya K.] Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal. RP Gibbons, RV (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM robert.gibbons@afrims.org RI Valle, Ruben/A-7512-2013 FU CDC FX This work was supported by CDC Global Disease Detection Program. NR 6 TC 4 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD DEC PY 2011 VL 105 IS 12 BP 740 EP 742 DI 10.1016/j.trstmh.2011.08.002 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 862DK UT WOS:000298069800010 PM 21955739 ER PT J AU Grant-Klein, RJ Altamura, LA Schmaljohn, CS AF Grant-Klein, Rebecca J. Altamura, Louis A. Schmaljohn, Connie S. TI Progress in recombinant DNA-derived vaccines for Lassa virus and filoviruses SO VIRUS RESEARCH LA English DT Review DE Ebolavirus; Marburgvirus; Lassa virus; Recombinant DNA vaccine; Filovirus ID EBOLA HEMORRHAGIC-FEVER; PROTECT GUINEA-PIGS; STABLE SIGNAL PEPTIDE; LINKED-IMMUNOSORBENT-ASSAY; EQUINE ENCEPHALITIS-VIRUS; NONHUMAN-PRIMATES; MARBURG-VIRUS; DENDRITIC CELLS; ENVELOPE GLYCOPROTEIN; RHESUS-MONKEYS AB Developing vaccines for highly pathogenic viruses such as those causing Lassa, Ebola, and Marburg hemorrhagic fevers is a daunting task due to both scientific and logistical constraints. Scientific hurdles to overcome include poorly defined relationships between pathogenicity and protective immune responses, genetic diversity of viruses, and safety in a target population that includes a large number of individuals with compromised immune systems. Logistical obstacles include the requirement for biosafety level-4 containment to study the authentic viruses, the poor public health infrastructure of the endemic disease areas, and the cost of developing these vaccines for use in non-lucrative markets. Recombinant DNA-based vaccine approaches offer promise of overcoming some of these issues. In this review, we consider the status of various recombinant DNA candidate vaccines against Lassa virus and filoviruses which have been tested in animals. Published by Elsevier B.V. C1 [Grant-Klein, Rebecca J.; Altamura, Louis A.; Schmaljohn, Connie S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Schmaljohn, CS (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM connie.schmaljohn@us.army.mil NR 137 TC 14 Z9 14 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 EI 1872-7492 J9 VIRUS RES JI Virus Res. PD DEC PY 2011 VL 162 IS 1-2 SI SI BP 148 EP 161 DI 10.1016/j.virusres.2011.09.005 PG 14 WC Virology SC Virology GA 862WH UT WOS:000298124300016 PM 21925552 ER PT J AU Nayback-Beebe, AM Yoder, LH AF Nayback-Beebe, Ann M. Yoder, Linda H. TI Social Conflict Versus Social Support: What is More Influential in Mental Health Symptom Severity for Female Service Members? SO ARCHIVES OF PSYCHIATRIC NURSING LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; GULF-WAR-I; DEPLOYMENT-RELATED EXPERIENCES; RISK-FACTORS; PSYCHOMETRIC CHARACTERISTICS; IPR INVENTORY; PRIMARY-CARE; VETERANS; DEPRESSION; MILITARY AB Research has validated the importance of postdeployment social support in mitigating the effects of combat deployment on mental health for female service members. However, the influence of social conflict on mental health during this period has not been explored. The purposes of this descriptive correlational study were (a) to examine the strength and direction of the relationships between social support, social conflict, and stressful life events to depression, anxiety, and posstraumatic stress disorder and (b) to determine whether the absence of social support or the presence social conflict was more influential to the severity of these symptoms. Published by Elsevier Inc. C1 USA, Austin, TX USA. Univ Texas Austin, Sch Nursing, Austin, TX 78712 USA. RP Nayback-Beebe, AM (reprint author), Brooke Army Med Ctr, Nursing Res Serv, 18815 Millhollow, San Antonio, TX 78258 USA. EM ann_nayback@yahoo.com; ann_nayback@us.army.mil FU Uniformed Services University of the Health Sciences; Department of Defense; U.S. Government; TriService Nursing Research Program [HU 0001-09-1-TSIO (N09-P12)] FX This project was sponsored by TriService Nursing Research Program, Uniformed Services University of the Health Sciences; however, the information or content and conclusions do not necessarily represent the official position or policy of nor should any official endorsement be inferred by, the TriService Nursing Research Program, Uniformed Services University of the Health Sciences, the Department of Defense, or the U.S. Government.; Funding for this study was provided by the TriService Nursing Research Program HU 0001-09-1-TSIO (N09-P12). NR 48 TC 3 Z9 3 U1 3 U2 7 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0883-9417 J9 ARCH PSYCHIAT NURS JI Arch. Psychiatr. Nurs. PD DEC PY 2011 VL 25 IS 6 BP 469 EP 478 DI 10.1016/j.apnu.2011.02.005 PG 10 WC Nursing; Psychiatry SC Nursing; Psychiatry GA 857KY UT WOS:000297718600008 PM 22114800 ER PT J AU Emanuel, P Jones, F Smith, M Huff, W Jaffe, R Roos, J AF Emanuel, Peter Jones, Franca Smith, Michael Huff, William Jaffe, Richard Roos, Jason TI THE KEY TO ENABLING BIOSURVEILLANCE IS COOPERATIVE TECHNOLOGY DEVELOPMENT SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Editorial Material ID EMERGING INFECTIOUS-DISEASES AB The world population will continue to face biological threats, whether they are naturally occurring or intentional events. The speed with which diseases can emerge and spread presents serious challenges, because the impact on public health, the economy, and development can be huge. The U.S. government recognizes that global public health can also have an impact on national security. This global perspective manifests itself in U.S. policy documents that clearly articulate the importance of biosurveillance in providing early warning, detection, and situational awareness of infectious disease threats in order to mount a rapid response and save lives. In this commentary, we suggest that early recognition of infectious disease threats, whether naturally occurring or man-made, requires a globally distributed array of interoperable hardware and software fielded in sufficient numbers to create a network of linked collection nodes. We argue that achievement of this end state will require a degree of cooperation that does not exist at this time-either across the U.S. federal government or among our global partners. Successful fielding of a family of interoperable technologies will require interagency research, development, and purchase ("acquisition") of biosurveillance systems through cooperative ventures that likely will involve our strategic allies and public-private partnerships. To this end, we propose leveraging an existing federal interagency group to integrate the acquisition of technologies to enable global biosurveillance. C1 [Emanuel, Peter] USA, Edgewood Chem & Biol Ctr, BioSci Div, Aberdeen Proving Ground, MD USA. [Jones, Franca] Execut Off President, White House Off Sci & Technol Policy, Washington, DC USA. [Huff, William] Def Threat Reduct Agcy, Chem Biol Technol Operat Support Div, Ft Belvoir, VA USA. [Jaffe, Richard] ANSER Inc, Arlington, VA USA. [Roos, Jason] Joint Program Execut Off Chem & Biol Def, Biosurveillance Chem & Biol Med Syst, Frederick, MD USA. RP Emanuel, P (reprint author), USA, ECBC, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM peter.emanuel@us.army.mil NR 22 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD DEC PY 2011 VL 9 IS 4 BP 386 EP 393 DI 10.1089/bsp.2011.0020 PG 8 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 859YM UT WOS:000297911800008 PM 22060034 ER PT J AU Norris, WE Goldberg, E Dubose, J AF Norris, William E. Goldberg, Eric Dubose, Joseph TI A bullet to the head SO GASTROINTESTINAL ENDOSCOPY LA English DT Editorial Material C1 [Norris, William E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Norris, William E.; Goldberg, Eric; Dubose, Joseph] Univ Maryland, Sch Med, Baltimore, MD 21201 USA. RP Norris, WE (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD DEC PY 2011 VL 74 IS 6 BP 1402 EP 1403 DI 10.1016/j.gie.2011.07.051 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 861AX UT WOS:000297992300035 PM 22136784 ER PT J AU Theiss, JL Fink, ML Gerber, JP AF Theiss, Justin L. Fink, Michael L. Gerber, John P. TI Deep Vein Thrombosis in a Young Marathon Athlete SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE clinical prediction rule; D-dimer assay; DVT ID VENOUS THROMBOSIS; D-DIMER; COMPRESSION ULTRASONOGRAPHY; PULMONARY-EMBOLISM; CLINICAL-MODEL; DIAGNOSIS; OUTPATIENTS; ACCURACY; PATIENT; RISK AB STUDY DESIGN: Resident's case problem. BACKGROUND: A 21-year-old athletic male college student presented to a direct-access physical therapy clinic with complaints of left calf pain 4 days in duration. After initial examination, a working diagnosis of calf strain was formulated. Three days following initial examination, the patient reported 80% improvement in symptoms and was performing activities of daily living pain free. Four weeks later, the patient returned with complaints of reoccurring calf pain. The patient's signs, symptoms, and history at subsequent follow-up no longer presented a consistent clinical picture of calf strain; therefore, a D-dimer assay was ordered to rule out a deep vein thrombosis (DVT). DIAGNOSIS: The D-dimer was elevated so the patient was admitted to the hospital and started on low-molecular-weight heparin. A compression ultrasound revealed an extensive left superficial femoral and popliteal DVT in this otherwise healthy athlete. DISCUSSION: Lower extremity DVT is a serious and potentially fatal disorder. Physical therapists need to be diagnostically vigilant for vascular pathology in all patients with extremity pain and swelling. Employing the best current evidencedbased screening tools to rule out vascular pathology, such as deep and superficial vein pathology, should be the goal of every clinician. The Wells score is one such screening tool that has proven to be beneficial in this area. This case report presents a dilemma in diagnosis and illustrates the importance of revisiting differential diagnoses with each patient encounter. Clinicians must consider the possibility of a DVT with every patient seen with posterior leg pain. LEVEL OF EVIDENCE: Diagnosis, level 4. J Ort hop Sports Phys Ther 2011;41(12):942-947 doi:10.2519/jospt.2011.3823 C1 [Theiss, Justin L.] US Mil Acad, Arvin Cadet Phys Therapy Clin, US Mil Baylor Univ Postprofess Phys Therapy Sport, West Point, NY 10996 USA. [Fink, Michael L.] Lebanon Valley Coll, Annville, PA USA. RP Theiss, JL (reprint author), US Mil Acad, Arvin Cadet Phys Therapy Clin, US Mil Baylor Univ Postprofess Phys Therapy Sport, 900 Washington Rd, West Point, NY 10996 USA. EM Justin.Theiss@amedd.army.mil NR 21 TC 6 Z9 6 U1 0 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 2011 VL 41 IS 12 BP 942 EP 947 DI 10.2519/jospt.2011.3823 PG 6 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 862WU UT WOS:000298125600006 PM 22146368 ER PT J AU Namsai, A Louisirirotchanakul, S Wongchinda, N Siripanyaphinyo, U Virulhakul, P Puthavathana, P Myint, KS Gannarong, M Ittapong, R AF Namsai, A. Louisirirotchanakul, S. Wongchinda, N. Siripanyaphinyo, U. Virulhakul, P. Puthavathana, P. Myint, K. S. Gannarong, M. Ittapong, R. TI Surveillance of hepatitis A and E viruses contamination in shellfish in Thailand SO LETTERS IN APPLIED MICROBIOLOGY LA English DT Article DE hepatitis A virus; hepatitis E virus; reverse transcription-polymerase chain reaction; shellfish ID ENTERIC VIRUSES; MOLLUSCAN SHELLFISH; BIVALVE SHELLFISH; PCR ASSAY; OYSTERS; FOOD; TRANSMISSION; NOROVIRUS; DIAGNOSIS; TISSUES AB Aims: To survey for hepatitis A virus (HAV) and hepatitis E virus (HEV) contamination in edible bivalve shellfish. Methods and Results: A total of 213 shellfish (52 oysters, 69 cockles and 92 mussels) collected from a culture farm and two retailed markets were investigated for HAV and HEV contamination by reverse transcription-polymerase chain reaction (RT-PCR) assay using HA2-HA1 (capsid region) and HE366-HE363 (ORF2/3 overlapping region) primers, respectively. It was found that 3.8% of the shellfish and 2.9 and 6.5% of the cockle and mussel, respectively, showed positive for HAV detection. Nucleotide sequencing of all the 8 HAV-positive shellfish revealed 97-100% similarity to HAV subgenotype IA. Interestingly, viruses were found more frequently in the gills than in digestive tissue (4.5% vs 0.5%, P = 0.045). All the shellfish were negative for HEV. Conclusion: Significant contamination of HAV in edible bivalve shellfish was observed. Beside digestive tissue, gills are one of the important samples for viral genome detection. Significance and Impact of the study: HAV-contaminated shellfish can play a role as reservoirs and/or vehicles in faecal-oral transmission in Thailand, and further monitoring of such a contamination is required. C1 [Namsai, A.; Louisirirotchanakul, S.; Puthavathana, P.] Mahidol Univ, Dept Microbiol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. [Wongchinda, N.; Ittapong, R.] Fishery Technol Dev Div, Bangkok, Thailand. [Siripanyaphinyo, U.] Res Collaborat Ctr Emerging & Re Emerging Infect, Dept Med Sci, Nonthaburi, Thailand. [Virulhakul, P.] Cent Govt, Dept Fisheries, Bangkok, Thailand. [Myint, K. S.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Gannarong, M.] Fish Inspect & Qual Control Div, Surat Thani, Thailand. RP Louisirirotchanakul, S (reprint author), Mahidol Univ, Dept Microbiol, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. EM sudaloui@yahoo.com NR 30 TC 18 Z9 18 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0266-8254 J9 LETT APPL MICROBIOL JI Lett. Appl. Microbiol. PD DEC PY 2011 VL 53 IS 6 BP 608 EP 613 DI 10.1111/j.1472-765X.2011.03152.x PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 861KM UT WOS:000298017800005 PM 21929540 ER PT J AU Dias, JM Kuehne, AI Abelson, DM Bale, S Wong, AC Halfmann, P Muhammad, MA Fusco, ML Zak, SE Kang, E Kawaoka, Y Chandran, K Dye, JM Saphire, EO AF Dias, Joao M. Kuehne, Ana I. Abelson, Dafna M. Bale, Shridhar Wong, Anthony C. Halfmann, Peter Muhammad, Majidat A. Fusco, Marnie L. Zak, Samantha E. Kang, Eugene Kawaoka, Yoshihiro Chandran, Kartik Dye, John M. Saphire, Erica Ollmann TI A shared structural solution for neutralizing ebolaviruses SO NATURE STRUCTURAL & MOLECULAR BIOLOGY LA English DT Article ID EBOLA-VIRUS GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; EPITOPES; SEQUENCE; OUTBREAK; UGANDA; ENTRY; GP2 AB Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP(1,2) core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1-GP2 neutralize at a post-internalization step-probably fusion. C1 [Kuehne, Ana I.; Muhammad, Majidat A.; Zak, Samantha E.; Kang, Eugene; Dye, John M.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Dias, Joao M.; Abelson, Dafna M.; Bale, Shridhar; Fusco, Marnie L.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA. [Wong, Anthony C.; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA. [Halfmann, Peter; Kawaoka, Yoshihiro] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA. [Kawaoka, Yoshihiro] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Dept Special Pathogens, Tokyo, Japan. [Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA. RP Dye, JM (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM john.m.dye1@us.army.mil; erica@scripps.edu FU US National Institutes of Health (NIH) [U01 AI070530]; Skaggs Institute for Chemical Biology; NIH [R01 AI088027, R21 AI082437, T32 GM007288, T32 AI070117, R01 AI055519]; Albert Einstein College of Medicine FX We thank D. Burton and A. Hessell (The Scripps Research Institute, TSRI) for KZ52, M. Whitt (University of Tennessee Health Science Center) and D. Lyles (Wake Forest University School of Medicine) for anti-VSV IgG 23H12, J. Cunningham (Brigham and Women's Hospital) for rabbit anti-GP1 polyclonal antibody and I. Wilson of TSRI for critical reading of the manuscript. We would also like to thank C. Corbaci (TSRI) for assistance in figure preparation and the staff of the Advanced Photon Source Beamline 19-ID and the Advanced Light Source Beamlines 8.2.2 and 8.3.1 for assistance and for the use of their US Department of Energy-supported facilities. E.O.S. wishes to acknowledge US National Institutes of Health (NIH) grant U01 AI070530, the Skaggs Institute for Chemical Biology, a Career Award in the Biomedical Sciences and an Investigator in the Pathogenesis of Infectious Disease Award from the Burroughs Welcome Fund. K.C. acknowledges support from NIH grants R01 AI088027 and R21 AI082437 and from institutional funds of the Albert Einstein College of Medicine.; A.C.W. was supported by NIH training grants T32 GM007288 and T32 AI070117. Y.K. acknowledges support from NIH R01 AI055519 and membership within and support from the Region V 'Great Lakes' Regional Center for Excellence for Biodefense and Emerging Infectious Diseases Research (RCE) Program (NIH award 2 U54 AI057153). J.M. Dye wishes to acknowledge support from the Defense Threat Reduction Agency (DTRA K.K0001_07_RD_B). Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. NR 20 TC 55 Z9 60 U1 0 U2 17 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 1545-9993 J9 NAT STRUCT MOL BIOL JI Nat. Struct. Mol. Biol. PD DEC PY 2011 VL 18 IS 12 BP 1424 EP 1427 DI 10.1038/nsmb.2150 PG 4 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 861IC UT WOS:000298011600033 PM 22101933 ER PT J AU Block, FJ Felstead, EB Macdonald, TG Macker, JP Russell, HB Stark, W Swami, A AF Block, Frederick J. Felstead, E. Barry Macdonald, Thomas G. Macker, Joseph P. Russell, Harlan B. Stark, Wayne Swami, Ananthram TI Advances in Military Networking and Communications SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Editorial Material C1 [Block, Frederick J.] MIT, Lincoln Lab, Adv Satcom Syst & Operat Grp, Lexington, MA 02173 USA. [Felstead, E. Barry] Commun Res Ctr, Ottawa, ON K2H 8S2, Canada. [Macdonald, Thomas G.] MIT, Lincoln Lab, Grp 63, Lexington, MA 02173 USA. [Macker, Joseph P.] USN, Res Lab, Div Informat Technol, Washington, DC 20375 USA. [Russell, Harlan B.] Clemson Univ, Dept Elect & Comp Engn, Clemson, SC 29631 USA. [Stark, Wayne] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Swami, Ananthram] USA, Res Lab, Washington, DC USA. RP Block, FJ (reprint author), MIT, Lincoln Lab, Adv Satcom Syst & Operat Grp, 244 Wood St, Lexington, MA 02173 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD DEC PY 2011 VL 29 IS 10 BP 1913 EP 1915 DI 10.1109/JSAC.2011.111201 PG 3 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 852FP UT WOS:000297341300001 ER PT J AU Rodway, GW Muza, SR AF Rodway, George W. Muza, Stephen R. TI Fighting in Thin Air: Operational Wilderness Medicine in High Asia SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE high altitude; altitude sickness; acclimatization; history; military ID INTERMITTENT HYPOXIC EXPOSURE; ACUTE MOUNTAIN-SICKNESS; MODERATE ALTITUDE; CARBOHYDRATE SUPPLEMENTATION; ENDURANCE PERFORMANCE; EXERCISE PERFORMANCE; ACCLIMATIZATION; RESIDENTS; DEFICIT AB Objective.-The current conflict in Afghanistan is the first major military action in which the United States and other North Atlantic Treaty Organization (NATO) forces have found themselves regularly engaged in combat at high altitudes. However, high altitude warfare is not a new concept in Asia by any means. Methods.-This article will offer a short general historical review of high altitude warfare in Asia and then specifically address some of the operational challenges faced by troops carrying out missions at high altitude in the ongoing conflict in Afghanistan. Additionally, there will be discussion of evidence-based interventions being used to attempt to maintain optimal health of the warfighter at high altitude in this theater of operations. Conclusions.-Years of research into how to alleviate the problematic nature of military operations in the high altitude environment has resulted in extensive risk management recommendations from the US Army, specifically aimed at preventing altitude-related casualties. C1 [Rodway, George W.] Univ Utah, Coll Nursing, Salt Lake City, UT 84112 USA. [Rodway, George W.] Univ Utah, Sch Med, Salt Lake City, UT 84112 USA. [Muza, Stephen R.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP Rodway, GW (reprint author), Univ Utah, Coll Nursing, 10 South,2000 East, Salt Lake City, UT 84112 USA. EM gwrodway@hotmail.com NR 36 TC 8 Z9 8 U1 2 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD WIN PY 2011 VL 22 IS 4 BP 297 EP 303 PG 7 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 860RV UT WOS:000297966300002 PM 22137862 ER PT J AU Heiner, JD Simmons, EA Hile, DC Wedmore, IS AF Heiner, Jason D. Simmons, Emily A. Hile, David C. Wedmore, Ian S. TI A Blinded, Randomized, Palatability Study Comparing Variations of 2 Popular Field Water Disinfection Tablets SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Article DE water disinfection; palatability; halogenation; iodine; chlorine dioxide AB Objective.-Halogen-based water disinfection tablets may lender an unpleasant taste to treated water. Proposed safe additives such as ascorbic acid may reduce this objectionable taste. We compared the palatability of 2 field water disinfectants: iodine-based tetraglycine hydroperiodide (TGHP) and chlorine-based. chlorine dioxide (CD) both with and without the concomitant use of an ascorbic acid taste neutralizer. Methods.-Blinded participants randomly sampled 5 different distilled water samples containing combinations of disinfectant tablets and ascorbic acid: 1) water; 2) water with TGHP; 3) water with CD; 4) water with TGHP plus ascorbic acid; and 5) water with CD plus ascorbic acid. Participants rated beverage taste via a 100 mm visual analogue scale (VAS) and ranked the samples from "most pleasant" to "least pleasant." Results.-Sixty participants evaluated the samples. On the VAS, water with TGHP tasted worst and water with CD tasted second worst. Water with TGHP plus ascorbic acid, water alone, and water with CD plus ascorbic acid measured similarly as significantly best tasting. Water with TGHP was ranked by 58% as "least pleasant" tasting, while water with TGHP and ascorbic acid was ranked by 40% as "most pleasant" tasting. Conclusions.-Participants found halogen-based disinfected water significantly less palatable prior to the addition of ascorbic acid. Addition of ascorbic acid to treated water created a beverage of similar preference to distilled water. These results may increase compliance with the use of disinfecting tablets by increasing the palatability of drinking water made potable via addition of ascorbic acid to halogen-based chemical disinfection. C1 [Heiner, Jason D.] Brooke Army Med Ctr, Dept Emergency Med, Houston, TX 78234 USA. [Simmons, Emily A.; Hile, David C.; Wedmore, Ian S.] Madigan Army Med Ctr, Dept Emergency Med, Ft Lewis, WA USA. RP Heiner, JD (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM jason.heiner1@us.army.mil NR 10 TC 3 Z9 3 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD WIN PY 2011 VL 22 IS 4 BP 329 EP 332 PG 4 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 860RV UT WOS:000297966300008 PM 22137863 ER PT J AU Simon, TE Scott, JA Brockmeyer, JR Rice, RC Frizzi, JD Husain, FA Choi, YU AF Simon, Todd E. Scott, Joshua A. Brockmeyer, Joel R. Rice, Robert C. Frizzi, James D. Husain, Farah A. Choi, Yong U. TI Comparison of Staple-Line Leakage and Hemorrhage in Patients Undergoing Laparoscopic Sleeve Gastrectomy with or Without Seamguard SO AMERICAN SURGEON LA English DT Article ID GASTRIC BYPASS; REINFORCEMENT; TRIAL AB Laparoscopic sleeve gastrectomy (LSG) has been recognized as a primary procedure for the surgical management of morbid obesity. Staple-line leaks and hemorrhage are two associated complications. Staple-line buttressing materials have been suggested to decrease these complications. When used during LSG, few published papers exist that compare the incidence of leak or hemorrhage to that of nonreinforced staple-lines. The purpose of this study was to compare the incidence of leak and hemorrhage in patients who did and did not receive reinforcement with Seamguard (W.L. Gore & Associates, Flagstaff, AZ). This is a retrospective analysis of patients undergoing LSG. All patients met National Institutes of Health criteria and each had an extensive preoperative evaluation. Data was collected from inpatient and outpatient medical records. Fifty-nine patients received reinforcement and 80 patients did not. There was no significant difference in mean body mass index, age, or gender make-up between the two groups. The overall incidence of leak was 3.60 per cent. The incidence was 3.39 per cent in patients who received reinforcement and 3.75 per cent in those who did not. This was not statistically significant. There was no incidence of staple-line hemorrhage in either group. There is no conclusive evidence that Seamguard reduces staple-line leakage or hemorrhage. Studies involving a larger number of patients are necessary before recommending staple-line reinforcement. C1 [Simon, Todd E.; Scott, Joshua A.; Brockmeyer, Joel R.; Rice, Robert C.; Frizzi, James D.; Husain, Farah A.; Choi, Yong U.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Simon, TE (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM te.simon@yahoo.com NR 12 TC 16 Z9 16 U1 0 U2 4 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD DEC PY 2011 VL 77 IS 12 BP 1665 EP 1668 PG 4 WC Surgery SC Surgery GA 857LV UT WOS:000297720900019 PM 22273227 ER PT J AU Sambasivan, CN Underwood, SJ Kuehn, RB Kiraly, LN Hamilton, GJ Flaherty, SF Dorlac, WC Schreiber, MA AF Sambasivan, Chitra N. Underwood, Samantha J. Kuehn, Reed B. Kiraly, Laszlo N. Hamilton, Gregory J. Flaherty, Stephen F. Dorlac, Warren C. Schreiber, Martin A. TI Management and Outcomes of Traumatic Colon Injury in Civilian and Military Patients SO AMERICAN SURGEON LA English DT Article; Proceedings Paper CT 96th Annual Clinical Congress of the American-College-of-Surgeons (ACS) CY OCT 03-07, 2010 CL Washington, DC SP Amer Coll Surg (ACS) ID OPERATION-IRAQI-FREEDOM; DAMAGE CONTROL LAPAROTOMY; PRIMARY REPAIR; PRIMARY ANASTOMOSIS; CONTROL SURGERY; COMBAT; RESECTION; TRIAL; DEATH; SAFE AB Divergent injury patterns may indicate the need for differing strategies in combat and civilian trauma patients. This study aims to compare outcomes of colon injury management in these two populations. Parallel retrospective reviews were conducted comparing warfighters (n = 59) injured downrange and subsequently transferred to the United States with civilians (n = 30) treated at a United States Level I trauma center. Patient characteristics, mechanisms of injury, treatment course, and complications were compared. The civilian (CP) and military (MP) populations did not differ in Injury Severity Score (MP 20 vs CP 26; P = 0.41). The MP experienced primarily blast injuries (51%) as opposed to blunt trauma (70%; P < 0.01) in the CP. The site of colon injury did not differ between groups (P = 0.15). Initial management was via primary repair (53%) and resection and anastomosis (27%) in the CP versus colostomy creation (47%) and stapled ends (32%) in the MP (P < 0.001). Ultimately, the CP and MP experienced equivalent continuity rates (90%). Overall complications (MP 68% vs CF 53%; P = 0.18) and mortality (MP 3% vs CP 3%; P = 0.99) did not differ between the two groups. The CF and MP experience different mechanisms and initial management of colon injury. Ultimately, continuity is restored in the majority of both populations. C1 [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Portland, OR 97239 USA. [Kuehn, Reed B.; Dorlac, Warren C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Schreiber, MA (reprint author), Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, 3181 SW Sam Jackson Pk Rd Mail Code L611, Portland, OR 97239 USA. EM schreibm@ohsu.edu NR 28 TC 2 Z9 2 U1 0 U2 5 PU SOUTHEASTERN SURGICAL CONGRESS PI CUMMING PA 115 SAMARITAN DR, #200, CUMMING, GA 30040-2354 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD DEC PY 2011 VL 77 IS 12 BP 1685 EP 1691 PG 7 WC Surgery SC Surgery GA 857LV UT WOS:000297720900023 PM 22273231 ER PT J AU Lee, CH Hankus, ME Tian, L Pellegrino, PM Singamaneni, S AF Lee, Chang H. Hankus, Mikella E. Tian, Limei Pellegrino, Paul M. Singamaneni, Srikanth TI Highly Sensitive Surface Enhanced Raman Scattering Substrates Based on Filter Paper Loaded with Plasmonic Nanostructures SO ANALYTICAL CHEMISTRY LA English DT Article ID GOLD NANOPARTICLES; SINGLE-MOLECULE; EXCITATION SPECTROSCOPY; COLLOID MONOLAYERS; DIFFERENT SHAPES; SERS; BACTERIA; IDENTIFICATION; NOBLE; FILM AB We report a novel surface enhanced Raman scattering (SERS) substrate platform based on a common filter paper adsorbed with plasmonic nanostructures that overcomes many of the challenges associated with existing SERS substrates. The paper-based design results in a substrate that combines all of the advantages of conventional rigid and planar SERS substrates in a dynamic flexible scaffolding format. In this paper, we discuss the fabrication, physical characterization, and SERS activity of our novel substrates using nonresonant analytes. The SEAS substrate was found to be highly sensitive, robust, and amiable to several different environments and target analytes. It is also cost-efficient and demonstrates high sample collection efficiency and does not require complex fabrication methodologies. The paper substrate has high sensitivity (0.5nM trans-1,2-bis(4-pyridyl)ethene (BPE)) and excellent reproducibility (similar to 15% relative standard deviation (RSD)). The paper substrates demonstrated here establish a novel platform for integrating SERS with already existing analytical techniques such as chromatography and microfluidics, imparting chemical specificity to these techniques. C1 [Hankus, Mikella E.; Pellegrino, Paul M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [Lee, Chang H.; Tian, Limei; Singamaneni, Srikanth] Washington Univ, Dept Mech Engn & Mat Sci, St Louis, MO 63130 USA. RP Pellegrino, PM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM paul.m.pellegrino.civ@mail.mil; singamaneni@wustl.edu RI Hankus, Mikella/A-9005-2012; Singamaneni, Srikanth/A-8010-2008 FU Army Research Office (ARO); Army Research Lab (ARL) [W911NF-11-2-0091] FX The authors thank Prof. Younan Xia from Biomedical Engineering at Washington University for providing access to the confocal Raman microscopy system and Dr. Ramesh Kattumenu at Washington University for technical help. The work was supported by Army Research Office (ARO) and Army Research Lab (ARL) under Contract No. W911NF-11-2-0091. NR 66 TC 99 Z9 101 U1 12 U2 178 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD DEC 1 PY 2011 VL 83 IS 23 BP 8953 EP 8958 DI 10.1021/ac2016882 PG 6 WC Chemistry, Analytical SC Chemistry GA 854FZ UT WOS:000297481700020 PM 22017379 ER PT J AU Sandor, MT Kecskes, LJ He, Q Xu, J Wu, Y AF Sandor, Magdalena T. Kecskes, Laszlo J. He Qiang Xu Jian Wu Yue TI Correlation of mechanical properties in bulk metallic glasses with Al-27 NMR characteristics SO CHINESE SCIENCE BULLETIN LA English DT Article DE bulk metallic glass; nuclear magnetic resonance; knight shift; magnetic susceptibility; mechanical properties ID SUPERCOOLED LIQUID REGION; CU AMORPHOUS-ALLOYS; ELECTRONIC-STRUCTURE; ZR; TRANSITION; NI; STRENGTH AB We report Al-27 NMR and magnetic susceptibility measurements of Zr and ZrHf-based bulk metallic glasses (BMGs). Al-27 NMR Knight shift shows that there exists a clear correlation between the local electronic properties at Al sites and mechanical properties. In addition, magnetic susceptibility measurements also provide clues on the influence of the electronic states, especially the strong influence of d-orbital characteristics on the mechanical properties of toughness and hardness. C1 [Sandor, Magdalena T.; Wu Yue] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. [Kecskes, Laszlo J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [He Qiang; Xu Jian] Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China. RP Wu, Y (reprint author), Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. EM yuewu@physics.unc.edu RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 FU U. S. Army Research Office [W911NF-09-1-0343] FX This work was supported by the U. S. Army Research Office (W911NF-09-1-0343). NR 30 TC 3 Z9 3 U1 2 U2 16 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 1001-6538 J9 CHINESE SCI BULL JI Chin. Sci. Bull. PD DEC PY 2011 VL 56 IS 36 BP 3937 EP 3941 DI 10.1007/s11434-011-4834-z PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 859HG UT WOS:000297866900009 ER PT J AU Tully, CC Hinkle, MK McCall, S Griffith, ME Murray, CK Hospenthal, DR AF Tully, Charla C. Hinkle, Mary K. McCall, Suzanne Griffith, Matthew E. Murray, Clinton K. Hospenthal, Duane R. TI Efficacy of minocycline and tigecycline in a hamster model of leptospirosis SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE Leptospirosis; Therapy; Minocycline; Tigecycline; Hamster AB Leptospirosis is a widespread zoonotic infection characterized by acute febrile illness. Severely ill patients may require empiric treatment with broad-spectrum antibiotics prior to definitive diagnosis. We evaluated the efficacy of minocycline and tigecycline against leptospirosis in a hamster model. Hamsters were treated with either minocycline (5, 10, or 25 mg/kg per day) or tigecycline (5, 10, or 25 mg/kg per day) for 5 days. Controls included untreated animals and doxycycline-treated animals (5 mg/kg per day). Nine days after infection, all untreated animals were dead. All treated hamsters survived to the end of study (day 21). Study groups showed significantly improved survival compared to the untreated group (P < .01). Minocycline and tigecycline showed survival benefit comparable to the standard treatment, doxycycline. In the absence of doxycycline, minocycline may be considered as an alternative, while tigecycline may be useful in the management of severely ill patients prior to a definitive diagnosis. Published by Elsevier Inc. C1 [Hinkle, Mary K.; Griffith, Matthew E.; Murray, Clinton K.; Hospenthal, Duane R.] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Tully, Charla C.] Wilford Hall USAF Med Ctr, Dept Med, Lackland AFB, TX 78236 USA. [McCall, Suzanne] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center FX This work is supported by the Global Emerging Infections Surveillance and Response System (GEIS), a division of the Armed Forces Health Surveillance Center. NR 13 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD DEC PY 2011 VL 71 IS 4 BP 366 EP 369 DI 10.1016/j.diagmicrobio.2011.08.018 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 854YD UT WOS:000297529800005 PM 22018938 ER PT J AU Taniuchi, M Verweij, JJ Sethabutr, O Bodhidatta, L Garcia, L Maro, A Kumburu, H Gratz, J Kibiki, G Houpt, ER AF Taniuchi, Mami Verweij, Jaco J. Sethabutr, Orntipa Bodhidatta, Ladaporn Garcia, Lynne Maro, Athanasia Kumburu, Happiness Gratz, Jean Kibiki, Gibson Houpt, Eric R. TI Multiplex polymerase chain reaction method to detect Cyclospora, Cystoisospora, and Microsporidia in stool samples SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article DE PCR; Microsporidia; Cystoisospora belli; Cystoisospora; Isospora belli; Isospora; Diarrhea; Enteropathogens; Encephalitozoon intestinalis; Enterocytozoon bieneusi; Cyclospora cayetanensis; Cyclospora; Multiplex PCR; Fecal PCR; Stool PCR; Luminex ID REAL-TIME PCR; CAYETANENSIS AB Cyclospora, Cystoisospora, and Microsporidia are eukaryotic enteropathogens that are difficult to detect in stool samples because they require special stains and microscopy. We developed a multiplex polymerase chain reaction (PCR) reaction with 4 primer sets to amplify Cyclospora cayetanensis, Cystoisospora belli, Enterocytozoon bieneusi, and Encephalitozoon intestinalis. Detection of the amplicon is through specific probes coupled to Luminex beads. Sensitivity of the assay was evaluated using Encephalitozoon intestinalis spores and revealed detection of 10(1) spores spiked into stool. No cross-reactivity was observed. We evaluated the assay on diarrheal specimens from Thailand, Tanzania, Indonesia, and the Netherlands that had been previously tested by microscopy, and the assay yielded 87-100% sensitivity and 88-100% specificity. Microscopy-negative/PCR-positive samples had lower Luminex values, suggesting they were true but with lower burden infections. In summary, this is a convenient single PCR reaction that can detect Cyclospora, Cystoisospora, and Microsporidia without the need for cumbersome microscopic analysis. (C) 2011 Elsevier Inc. All rights reserved. C1 [Taniuchi, Mami] Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA. [Verweij, Jaco J.] Leiden Univ, Med Ctr, Dept Parasitol, Clin Microbiol Lab, NL-2300 RC Leiden, Netherlands. [Verweij, Jaco J.] Leiden Univ, Med Ctr, Dept Med Microbiol, Clin Microbiol Lab, NL-2300 RC Leiden, Netherlands. [Sethabutr, Orntipa; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Garcia, Lynne] LSG Associates, Santa Monica, CA 90402 USA. [Maro, Athanasia; Kumburu, Happiness; Gratz, Jean; Kibiki, Gibson] Kilimanjaro Christian Med Ctr, Biotechnol Lab, Moshi, Tanzania. RP Taniuchi, M (reprint author), Univ Virginia, Dept Med, Div Infect Dis & Int Hlth, POB 801340, Charlottesville, VA 22908 USA. EM mt2f@virginia.edu FU National Institutes of Health [U01 AI075396]; Bill and Melinda Gates Foundation FX This work was supported by National Institutes of Health grant U01 AI075396 and by the Bill and Melinda Gates Foundation. NR 11 TC 21 Z9 22 U1 3 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD DEC PY 2011 VL 71 IS 4 BP 386 EP 390 DI 10.1016/j.diagmicrobio.2011.08.012 PG 5 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 854YD UT WOS:000297529800008 PM 21982218 ER PT J AU Convertino, M Kiker, GA Munoz-Carpena, R Chu-Agor, ML Fischer, RA Linkov, I AF Convertino, M. Kiker, G. A. Munoz-Carpena, R. Chu-Agor, M. L. Fischer, R. A. Linkov, I. TI Scale- and resolution-invariance of suitable geographic range for shorebird metapopulations SO ECOLOGICAL COMPLEXITY LA English DT Article DE Species distribution niche-models; Habitat suitability; Resolution; Scale; Maximum entropy; Snowy Plover; Land-cover; Climate change ID SPECIES DISTRIBUTION MODELS; SEA-LEVEL RISE; HABITAT SUITABILITY MODEL; SAMPLE SELECTION BIAS; PSEUDO-ABSENCE DATA; PRESENCE-ONLY DATA; GULF-OF-MEXICO; CLIMATE-CHANGE; MAXIMUM-ENTROPY; STATISTICAL-MECHANICS AB The habitat suitability of a shorebird metapopulation is studied as a function of the scale (extent) and resolution (grain-size) of the environmental covariates with a maximum entropy species distribution model (MAXENT) for integration with climate change simulations. For this study, the species considered is the Snowy Plover (Charadrius a. nivosus), which is a threatened shorebird whose geographic range spans the northwest and southwestern gulf coasts of Florida. The habitat suitability is analyzed at different resolutions by coarsening the classes of the ecogeographical variables with two algorithms: (i) preserving the information of each class at the finer resolution (conservative algorithm); and (ii) considering the most frequent class (majority algorithm). Ultimately, the most suitable habitat is found to be estuarine and ocean beaches made of alkaline medium and fine white sand and silt. The model fit to the observed species distribution decreases with the resolution. Due to the loss of the physical habitat (barrier islands) resulting from the coarsening operation, there is a threshold below which the model fails to predict the species distribution. As a result, the suitable geographic range is resolution-invariant below a resolution-threshold that is determined by the geomorphological features of the landscape rather than by biological constrains. This result holds for both the coarsening algorithms, however the conservative algorithm allows a continuous mapping of the habitat suitability. The suitable geographical range is found to be scale- and resolution-invariant, yet the habitat suitability at-a-point appears scale-dependent due to the strong heterogeneity of the ecogeographical variables. The scale- and resolution-invariance of the suitable geographic range appears a universal result for metapopulations of different species. This is important for reducing the uncertainty of population viability models that are based also on the choice of extent and grain-size of habitat predictions. However, attention must be paid in choosing a resolution that is not too large in order to correctly represent the physical habitat of the species. This implies a potential increase in the effectiveness of conservation campaigns to face the threats of climate change, such as sea-level rise for the Snowy Plover. (C) 2011 Elsevier B.V. All rights reserved. C1 [Convertino, M.; Kiker, G. A.; Munoz-Carpena, R.; Chu-Agor, M. L.] Univ Florida, Dept Agr & Biol Engn IFAS, Gainesville, FL 32611 USA. [Convertino, M.; Linkov, I.] USACE Engn Res & Dev Ctr ERDC, Risk & Decis Sci Area, Concord, MA USA. [Fischer, R. A.] USACE Engn Res & Dev Ctr ERDC, Environm Lab, Vicksburg, MS USA. [Linkov, I.] Carnegie Mellon Univ, EPP Dept, Pittsburgh, PA 15213 USA. RP Convertino, M (reprint author), Univ Florida, Dept Agr & Biol Engn IFAS, Frazier Rogers Hall,Museum Rd,POB 110570, Gainesville, FL 32611 USA. EM mconvertino@ufl.edu RI Munoz-Carpena, Rafael/A-7588-2010; OI Munoz-Carpena, Rafael/0000-0003-2838-1514; Chu, Ma Librada/0000-0003-3732-7165 FU SERDP [SI-1699] FX The authors acknowledge the funding from SERDP (project SI-1699). M.C. particularly acknowledges Kate Norris of the GEOPLAN Center at the University of Florida for the GIS support and Jason K. Blackburn at the Emerging Pathogens Institute & Department of Geography at the University of Florida for the instructive discussion about the species distribution models. Also Raya Pruner, M.Sc. 2010 at University of Florida (Wildlife Ecology Department), is kindly acknowledged for the insights about the Snowy Plover field data collection, and Douglass Nancy of the Southwest Region Center of Florida Fish and Wildlife Conservation Commission for further insights about the bird sampling campaign along the Gulf coasts. Chris Burney and Patricia Kelly (Florida Shorebird Working Group, Florida FWC) are also acknowledged for providing additional data of the Snowy Plover. M.C. greatly acknowledges the Associate Editor (Dr. J. Kolasa) for the comments on the manuscript that greatly improved the work. B. Trump (Carnegie Mellon University) is acknowledged for reviewing the latest version of the manuscript. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. NR 116 TC 13 Z9 13 U1 2 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1476-945X J9 ECOL COMPLEX JI Ecol. Complex. PD DEC PY 2011 VL 8 IS 4 BP 364 EP 376 DI 10.1016/j.ecocom.2011.07.007 PG 13 WC Ecology SC Environmental Sciences & Ecology GA 859KH UT WOS:000297874800012 ER PT J AU St Leger, A Deese, A Yakaski, J Nwankpa, C AF St Leger, Aaron Deese, Anthony Yakaski, Jeffrey Nwankpa, Chika TI Controllable analog emulator for power system analysis SO INTERNATIONAL JOURNAL OF ELECTRICAL POWER & ENERGY SYSTEMS LA English DT Article DE Analog computers; Analog processing circuits; Power system modeling; Power system simulation ID TRANSIENT NETWORK ANALYZER; SIMULATION; STABILITY AB This paper details the development of a controllable analog emulator for power system analysis. The emulator consists of reconfigurable analog hardware for power system emulation and a digital computer, along with associated software, for configuration, control, calibration and data acquisition. The analog hardware is fully controllable via the software interface. System parameters, initial conditions, integration, faults and contingencies can be created or altered via the software with no changes or manual intervention to the analog hardware. This advance overcomes one of the larger drawbacks of older analog computers, which was the need for manual configuration and calibration. The emulation methodology is presented in this paper as well as power system modeling, both theoretical and in analog hardware. The software interface and control is also presented. To validate the operation of the emulator two examples are shown from a prototype emulator. The first being a steady state power flow solution, the second computes the critical clearing time of a generator fault for transient stability. Published by Elsevier Ltd. C1 [St Leger, Aaron] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. [Deese, Anthony] Coll New Jersey, Dept Elect & Comp Engn, Ewing, NJ USA. [Yakaski, Jeffrey] Lockheed Martin Corp, Moorestown, NJ USA. [Nwankpa, Chika] Drexel Univ, Dept Elect & Comp Engn, Philadelphia, PA 19104 USA. RP St Leger, A (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM aaron.stleger@usma.edu FU US Department of Energy [CH11170]; US National Science Foundation [ECS-0601647] FX The authors would like to thank the US Department of Energy for their financial support under Grant CH11170 and the US National Science Foundation for their financial support under Grant ECS-0601647. NR 29 TC 1 Z9 1 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0142-0615 J9 INT J ELEC POWER JI Int. J. Electr. Power Energy Syst. PD DEC PY 2011 VL 33 IS 10 BP 1675 EP 1685 DI 10.1016/j.ijepes.2011.08.007 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA 859RI UT WOS:000297893100010 ER PT J AU Schuster, BE Ligda, JP Pan, ZL Wei, Q AF Schuster, B. E. Ligda, J. P. Pan, Z. L. Wei, Q. TI Nanocrystalline refractory metals for extreme condition applications SO JOM LA English DT Article ID SEVERE PLASTIC-DEFORMATION; ULTRAFINE GRAIN SIZES; HIGH-PRESSURE TORSION; MECHANICAL-PROPERTIES; UNIAXIAL COMPRESSION; SINGLE-CRYSTALS; SHEAR BANDS; BEHAVIOR; MICROSTRUCTURE; TUNGSTEN AB For the last decade, there has been research aimed at engineering plastic instability into the deformation behavior of body centered cubic (b.c.c.) metals. At dynamic strain rates, the adiabatic shear band deformation mode has been shown to improve the performance of kinetic energy penetrator materials. However, for some b.c.c. metals the transition to localized plastic deformation dominates at all strain rates. This limits the traditional engineering properties (e.g., ductility and toughness) and feasibility of incorporation into a long rod penetrator system. Recently, we demonstrated that nanocrystalline tantalum shows significant promise as it deforms via adiabatic shear bands in dynamic compression but shows significant tensile elongation in quasi-static deformation. C1 [Schuster, B. E.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Ligda, J. P.; Pan, Z. L.; Wei, Q.] Univ N Carolina, Charlotte, NC 28223 USA. RP Schuster, BE (reprint author), USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM brian.e.schuster@usarmy.mil RI Wei, Qiuming/B-7579-2008; Pan, Zhiliang/A-8061-2009 OI Pan, Zhiliang/0000-0003-3899-8761 FU U.S. Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073] FX The authors are grateful to L. S. Magness, W.N. Sharpe, B. G. Butler, X. L. Wu, and L.J. Kecskes; and would like to thank Professor R.Z. Valiev for providing the HPT Ta. Q. Wei would like to acknowledge the support from U.S. Army Research Laboratory under Contract No. W911QX-06-C-0124 and W911QX-08-C-0073. NR 37 TC 11 Z9 11 U1 3 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 J9 JOM-US JI JOM PD DEC PY 2011 VL 63 IS 12 BP 27 EP 31 DI 10.1007/s11837-011-0202-3 PG 5 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA 859IR UT WOS:000297870600006 ER PT J AU Hu, H Correll, M Kvecher, L Osmond, M Clark, J Bekhash, A Schwab, G Gao, D Gao, J Kubatin, V Shriver, CD Hooke, JA Maxwell, LG Kovatich, AJ Sheldon, JG Liebman, MN Mural, RJ AF Hu, Hai Correll, Mick Kvecher, Leonid Osmond, Michelle Clark, Jim Bekhash, Anthony Schwab, Gwendolyn Gao, De Gao, Jun Kubatin, Vladimir Shriver, Craig D. Hooke, Jeffrey A. Maxwell, Larry G. Kovatich, Albert J. Sheldon, Jonathan G. Liebman, Michael N. Mural, Richard J. TI DW4TR: A Data Warehouse for Translational Research SO JOURNAL OF BIOMEDICAL INFORMATICS LA English DT Article DE Data Warehouse; Translational research; Patient-centric data model; User interface; Ontology ID PATHOLOGISTS GUIDELINE RECOMMENDATIONS; BREAST-CANCER; CLINICAL-RESEARCH; BIOMEDICAL INFORMATICS; INTEGRATING BIOLOGY; AMERICAN-SOCIETY; ONTOLOGY; CHALLENGES; QUERY; TOOL AB The linkage between the clinical and laboratory research domains is a key issue in translational research. Integration of clinicopathologic data alone is a major task given the number of data elements involved. For a translational research environment, it is critical to make these data usable at the point-of-need. Individual systems have been developed to meet the needs of particular projects though the need for a generalizable system has been recognized. Increased use of Electronic Medical Record data in translational research will demand generalizing the system for integrating clinical data to support the study of a broad range of human diseases. To ultimately satisfy these needs, we have developed a system to support multiple translational research projects. This system, the Data Warehouse for Translational Research (DW4TR), is based on a light-weight, patient-centric modularly-structured clinical data model and a specimen-centric molecular data model. The temporal relationships of the data are also part of the model. The data are accessed through an interface composed of an Aggregated Biomedical-Information Browser (ABB) and an Individual Subject Information Viewer (ISIV) which target general users. The system was developed to support a breast cancer translational research program and has been extended to support a gynecological disease program. Further extensions of the DW4TR are underway. We believe that the DW4TR will play an important role in translational research across multiple disease types. (C) 2011 Elsevier Inc. All rights reserved. C1 [Hu, Hai; Kvecher, Leonid; Bekhash, Anthony; Schwab, Gwendolyn; Liebman, Michael N.; Mural, Richard J.] Windber Res Inst, Windber, PA 15963 USA. [Osmond, Michelle; Clark, Jim; Sheldon, Jonathan G.] InforSense LLC, London, England. [Correll, Mick; Kubatin, Vladimir] InforSense Ltd, Boston, MA USA. [Gao, De; Gao, Jun] InforSense Ltd, Shanghai, Peoples R China. [Shriver, Craig D.; Hooke, Jeffrey A.; Maxwell, Larry G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kovatich, Albert J.] MDR Global, Windber, PA USA. RP Hu, H (reprint author), Windber Res Inst, 620 7th St, Windber, PA 15963 USA. EM h.hu@wriwindber.org FU Clinical Breast Care Project; Gynecological Disease Program; US Department of Defense through Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD FX We thank Mr. Anton Oleynikov, Mr. Faruk Cay, Mr. Raveen Sharma, Dr. Csaba Mihaly, Mr. Eric Babyak, and Dr. Yonghong Zhang, for their help in this project. We thank Ms. Joni Kohr, Dr. Hallgeir Rui, and Mr. John Eberhardt for their help in manuscript preparation and revision. We also thank the anonymous reviewers for their constructive comments that resulted in enhanced quality of this paper. This work was supported by the Clinical Breast Care Project, and the Gynecological Disease Program, with funds from the US Department of Defense through Henry Jackson Foundation for the Advancement of Military Medicine, Rockville, MD. The views expressed in this paper are those of the authors and do not reflect the official policy of the Department of the Army. Department of Defense, or the government of the United States. NR 82 TC 22 Z9 23 U1 0 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1532-0464 EI 1532-0480 J9 J BIOMED INFORM JI J. Biomed. Inform. PD DEC PY 2011 VL 44 IS 6 BP 1004 EP 1019 DI 10.1016/j.jbi.2011.08.003 PG 16 WC Computer Science, Interdisciplinary Applications; Medical Informatics SC Computer Science; Medical Informatics GA 859VU UT WOS:000297904700011 PM 21872681 ER PT J AU O'Brien, DJ Baechle, DM Wetzel, ED AF O'Brien, D. J. Baechle, D. M. Wetzel, E. D. TI Design and performance of multifunctional structural composite capacitors SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE multifunctional materials; capacitor; dielectric breakdown; multifunctional efficiency; structural capacitor; pulsed power ID DIELECTRIC-BREAKDOWN STRENGTHS; EPOXY-BASED COMPOSITES; ELECTRIC BREAKDOWN; GLASS COMPOSITE; ENERGY-STORAGE; MECHANICAL STRESSES; RESIN; PET; TECHNOLOGIES; INTERFACE AB Dielectric capacitors with mechanical load-bearing capability have been constructed by laminating glass-epoxy prepregs with metalized film electrodes. Mechanical characterization and high-voltage testing are used to quantify the elastic modulus, mechanical strength, and dielectric energy density of these structural devices. An approach for predicting mass savings in systems utilizing multifunctional material structures is also presented. The experimental results show that, in spite of increases in void content with fiber volume fraction, overall structural capacitor performance is greatest at maximum fiber volume fraction. At these high-fiber volume fractions, the overall multifunctional performance of the structural capacitors is predicted to provide mass and volume savings over conventional designs. C1 [O'Brien, D. J.; Baechle, D. M.; Wetzel, E. D.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP O'Brien, DJ (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM danny.obrien@us.army.mil NR 64 TC 16 Z9 16 U1 1 U2 24 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD DEC PY 2011 VL 45 IS 26 BP 2797 EP 2809 DI 10.1177/0021998311412207 PG 13 WC Materials Science, Composites SC Materials Science GA 857YI UT WOS:000297761100009 ER PT J AU Yagnamurthy, S Chasiotis, I Lambros, J Polcawich, RG Pulskamp, JS Dubey, M AF Yagnamurthy, Sivakumar Chasiotis, Ioannis Lambros, John Polcawich, Ronald G. Pulskamp, Jeffrey S. Dubey, Madan TI Mechanical and Ferroelectric Behavior of PZT-Based Thin Films SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Digital image correlation (DIC); electroactive coefficient; hysteresis; Young's modulus ID PIEZOELECTRIC PROPERTIES; ACTUATORS; SILICON; MEMS; DEFORMATION; CERAMICS; NANOINDENTATION; MICROACTUATORS; SENSORS; HEAD AB The mechanical and ferroelectric behavior of freestanding lead zirconate titanate (PZT) -based thin film unimorph structures for microelectromechanical systems was investigated with uniaxial tension specimens of SiO(2)-TiPt-PZT-Pt, SiO(2)-TiPt-PZT, SiO(2)-TiPt, and individual SiO(2) and Pt films. Full-field strains obtained with digital image correlation were used to compute the stress versus strain curves for each film combination and the properties of the PZT layer. The mechanical response of the 1-mu m thick PZT films was nonlinear but nonhysteretic, and it deviated from linearity at 0.3-0.35% axial strain. The elastic modulus of the PZT was 84 +/- 3 GPa and 60.5 +/- 5 GPa in open and short circuit conditions, respectively. Failure of the PZT stacks initiated in the PZT layer at 510 +/- 35 MPa and 356 +/- 55 MPa, in open and short circuit conditions, respectively, while the presence of the top Pt electrode delayed failure initiation in the SiO(2)-TiPt-PZT-Pt stack compared to the SiO(2)-TiPt-PZT stack. The high field effective electroactive coefficient e(31,eff) calculated from biased PZT stacks subjected to various prestress amplitudes was in the range of -50 to -30 NV(-1)m(-1). The e31, eff was strongly dependent on the electric field for most applied stress amplitudes, but it remained constant with the applied field when the applied stress reached 400 MPa. C1 [Yagnamurthy, Sivakumar; Chasiotis, Ioannis; Lambros, John] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. [Polcawich, Ronald G.; Pulskamp, Jeffrey S.; Dubey, Madan] USA, Res Lab, Adelphi Lab Ctr, Adelphi, MD 20783 USA. RP Yagnamurthy, S (reprint author), Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. EM syagnam2@illinois.edu; chasioti@illinois.edu; lambros@illinois.edu; ronald.g.polcawich.civ@mail.mil; jeffrey.s.pulskamp.civ@mail.mil; madan.dubey.civ@mail.mil FU Army Research Office [W911NF-05-1-0063]; Air Force Office of Scientific Research [AF FA9550-09-1-0535] FX This work was supported by Army Research Office Grant W911NF-05-1-0063 and by the Air Force Office of Scientific Research under Grant AF FA9550-09-1-0535. Subject Editor S. M. Spearing. NR 45 TC 8 Z9 8 U1 1 U2 41 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD DEC PY 2011 VL 20 IS 6 BP 1250 EP 1258 DI 10.1109/JMEMS.2011.2167666 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 855TZ UT WOS:000297589200006 ER PT J AU Kamaladasa, RJ Liu, F Porter, LM Davis, RF Koleske, DD Mulholland, G Jones, KA Picard, YN AF Kamaladasa, Ranga J. . Liu, Fang Porter, Lisa M. Davis, Robert F. Koleske, Daniel D. Mulholland, Greg Jones, Kenneth A. Picard, Yoosuf N. TI Identifying threading dislocations in GaN films and substrates by electron channelling SO JOURNAL OF MICROSCOPY LA English DT Article DE Channelling contrast; chemical etch; ECCI; gallium nitride; screw; edge; TEM ID SURFACE STRESS-RELAXATION; GALLIUM NITRIDE; CONTRAST; MICROSCOPE; IMAGES; DIFFRACTION; DEFECTS; GROWTH AB Electron channelling contrast imaging of threading dislocations in GaN (0002) substrates and epitaxial films has been demonstrated using a conventional polepiece-mounted backscatter detector in a commercial scanning electron microscope. The influence of accelerating voltage and diffraction vector on contrast features denoting specific threading dislocation types has been studied. As confirmed by coordinated transmission electron microscopy analysis, electron channelling contrast imaging contrast features for edge-type threading dislocations are spatially smaller than mixed-type threading dislocations in GaN. This ability to delineate GaN edge threading dislocations from mixed type was also confirmed by defect-selective etch processing using molten MgO/KOH. This study validates electron channelling contrast imaging as a nondestructive and widely accessible method for spatially mapping and identifying dislocations in GaN with wider applicability for other single-crystal materials. C1 [Kamaladasa, Ranga J. .; Liu, Fang; Porter, Lisa M.; Davis, Robert F.; Picard, Yoosuf N.] Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. [Koleske, Daniel D.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Mulholland, Greg] Kyma Technol, Raleigh, NC USA. [Picard, Yoosuf N.] USA, Res Lab, Adelphi, MD USA. RP Kamaladasa, RJ (reprint author), Carnegie Mellon Univ, Pittsburgh, PA 15213 USA. EM rkamalad@andrew.cmu.edu RI Davis, Robert/A-9376-2011; OI Davis, Robert/0000-0002-4437-0885; Picard, Yoosuf/0000-0002-2853-5213 FU Army Research Office [58259-MS-II]; Berkman Faculty Development Fund; U.S. Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX The authors recognize financial support from the Army Research Office (Contract No. 58259-MS-II) managed by P. Varanasi, and from the Berkman Faculty Development Fund. The authors also appreciate insightful discussions with A. Winkelmann, M. De Graef, C. Trager-Cowan and for the technical assistance provided by Tom Nuhfer. Some samples were generated at Sandia National Laboratories, a multiprogram laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. NR 32 TC 6 Z9 6 U1 1 U2 23 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-2720 J9 J MICROSC-OXFORD JI J. Microsc.. PD DEC PY 2011 VL 244 IS 3 BP 311 EP 319 DI 10.1111/j.1365-2818.2011.03538.x PG 9 WC Microscopy SC Microscopy GA 858XT UT WOS:000297837300009 PM 21883210 ER PT J AU Barchie, MF Clive, KS Tyler, JA Sutcliffe, JB Kirkpatrick, AD Bell, LM Banks, KP Belenkiy, S Saenger, JS Peoples, GE AF Barchie, Matthew F. Clive, Kevin S. Tyler, Joshua A. Sutcliffe, Joseph B. Kirkpatrick, Aaron D. Bell, Lisa M. Banks, Kevin P. Belenkiy, Slava Saenger, Jeff S. Peoples, George E. TI Standardized Pretreatment Breast MRI-Accuracy and Influence on Mastectomy Decisions SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE breast cancer; imaging; treatment choice ID CANCER; RATES AB Background and Objectives: Routine pretreatment breast magnetic resonance imaging in newly diagnosed cancer patients remains controversial. We assess MRI accuracy and influence on mastectomy decisions after institution of standardized pretreatment MRI. Methods: A prospectively collected database of 74 consecutive new invasive breast cancer patients with pretreatment breast MRI was reviewed for treatment choice, radiologic, and pathologic results. Thirty-eight of 72 patients with available surgical records underwent mastectomy. Mastectomy preoperative and operative electronic records were reviewed for treatment decision analysis. Results: Seventeen of 72 (23.6%) invasive breast cancer patients were likely influenced to undergo mastectomy by new information from MRI. MRI reported that the multifocal/multicentric (MF/MC) rate was 20 of 72 (27.8%) versus 19 of 72 (26.4%) by surgical pathology. MRI sensitivity for MF/MC disease was 89.5% versus 11.8% for mammography. MRI specificity was 84.2%. All three false positives declined recommended preoperative biopsies. MRI MF/MC diagnosis highly correlated with pathology results, P < 0.001. Conclusions: Increased mastectomy rate from 29 to 52.8% after standardization of pre-treatment breast MRI for invasive cancer is largely due to MRI findings of increased extent of disease. These MRI findings correlate well with pathologic findings and appear to justify the performance of mastectomies in these patients. J. Surg. Oncol. 2011;104:741-745. (C) 2011 Wiley Periodicals, Inc. C1 [Barchie, Matthew F.; Sutcliffe, Joseph B.; Kirkpatrick, Aaron D.; Bell, Lisa M.; Banks, Kevin P.] Brooke Army Med Ctr, Dept Radiol, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. [Clive, Kevin S.; Tyler, Joshua A.; Belenkiy, Slava; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. [Saenger, Jeff S.] Brooke Army Med Ctr, Dept Pathol, San Antonio Uniformed Serv Hlth Educ Consortium, Ft Sam Houston, TX 78234 USA. RP Barchie, MF (reprint author), Brooke Army Med Ctr, Dept Radiol, San Antonio Uniformed Serv Hlth Educ Consortium, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM mbarchie@satx.rr.com NR 22 TC 8 Z9 9 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD DEC PY 2011 VL 104 IS 7 BP 741 EP 745 DI 10.1002/jso.21960 PG 5 WC Oncology; Surgery SC Oncology; Surgery GA 854QC UT WOS:000297508300007 PM 21618242 ER PT J AU Steedman, RS Sharp, MK AF Steedman, R. Scott Sharp, Michael K. TI Physical modelling analysis of the New Orleans levee breaches SO PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-GEOTECHNICAL ENGINEERING LA English DT Article DE embankments; failure; floods & floodworks AB As part of the Interagency Performance Evaluation Task Force (IPET) investigation into levee breaches in New Orleans following Hurricane Katrina, centrifuge modelling was undertaken of representative levee cross-sections on the 17th Street, Orleans and London Avenue Canals. Two mechanisms were observed leading to breaching of the levee in the models, both of which stemmed from a water-filled crack that formed in front of the flood wall. Depending on the foundation conditions and geometry of the levee and flood wall, the crack led either to a rotation of the flood wall landwards, with uplift and sliding on the top of the sand towards the landward toe of the levee, or to a translational (sliding) failure in the clay layer commencing from the bottom or toe of the flood wall. In the Orleans models no breach ensued, although it was clear these sections were close to failure. The centrifuge model tests identified, at an early stage in the IPET investigation, the importance of the 'gap' mechanism affecting the stability of the flood walls, and confirmed that levee geometry and flood wall depth of penetration, together with the underlying soil profile, were critical to the performance of the system under flood loading. C1 [Steedman, R. Scott] FInstRE Steedman & Associates Ltd, Reading, Berks, England. [Sharp, Michael K.] USACE Engn Res & Dev Ctr, Vicksburg, MS USA. RP Steedman, RS (reprint author), FInstRE Steedman & Associates Ltd, Reading, Berks, England. NR 13 TC 5 Z9 5 U1 0 U2 11 PU ICE PUBL PI LONDON PA 40 MARSH WALL, 2 FL, LONDON E14 9TP, ENGLAND SN 1353-2618 J9 P I CIVIL ENG-GEOTEC JI Proc. Inst. Civil Eng.-Geotech. Eng. PD DEC PY 2011 VL 164 IS 6 BP 353 EP 372 DI 10.1680/geng.8.00057 PG 20 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 853ST UT WOS:000297446700002 ER PT J AU Mal, S Yang, TH Jin, CM Nori, S Narayan, J Prater, JT AF Mal, Siddhartha Yang, Tsung-Han Jin, Chunming Nori, Sudhakar Narayan, J. Prater, J. T. TI d(0) Ferromagnetism in undoped ZnO thin films: Effect of thickness, interface and oxygen annealing SO SCRIPTA MATERIALIA LA English DT Article DE Magnetic thin films; Laser deposition; Annealing; Resistivity and conductivity; Interfaces AB We present a systematic study of the thickness dependency of the structural, electrical and magnetic properties of undoped ZnO thin films. The highest saturation moment (similar to 36.75 emu cm(-3)) was observed for the thinnest films. Both the undoped and 5% Co doped ZnO films of different thickness (0.066-1.1 mu m) showed a diamagnetic behavior upon annealing in oxygen. Activation energy of quenching of ferromagnetism revealed oxygen vacancies as the key mediating defect in ferromagnetic ZnO thin films. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Mal, Siddhartha; Yang, Tsung-Han; Jin, Chunming; Nori, Sudhakar; Narayan, J.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Prater, J. T.] USA, Div Mat Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Mal, S (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA. EM vbgyor@gmail.com RI Nori, Sudhakar/E-8111-2010 FU Army Research Office [W911NF-04-D-0003]; National Science Foundation (NSF) [0653722] FX The authors are pleased to acknowledge the support of the Army Research Office under Grant # W911NF-04-D-0003, the National Science Foundation under grant NSF # 0653722. NR 20 TC 7 Z9 7 U1 1 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD DEC PY 2011 VL 65 IS 12 BP 1061 EP 1064 DI 10.1016/j.scriptamat.2011.09.016 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 853TN UT WOS:000297448700008 ER PT J AU Webb, HE Fabianke-Kadue, EC Kraemer, RR Kamimori, GH Castracane, VD Acevedo, EO AF Webb, Heather E. Fabianke-Kadue, Emily C. Kraemer, Robert R. Kamimori, Gary H. Castracane, V. Daniel Acevedo, Edmund O. TI Stress Reactivity to Repeated Low-Level Challenges: A Pilot Study SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK LA English DT Article DE HPA axis; SA axis; Cortisol; Repeated stress; Repeated bouts ID REPEATED BOUTS; PSYCHOLOGICAL STRESS; ENDURANCE EXERCISE; CORTISOL-LEVELS; SALIVARY IGA; RESPONSES; CORTICOTROPIN; INDIVIDUALS; METABOLISM; GENDER AB The purpose of this study was to examine the effects of a mental challenge on cardiovascular and endocrine [epinephrine (EPI), norepinephrine (NE), and cortisol (CORT)] responses to subsequent low-intensity physical exertion. Twelve males (23.25 +/- A 0.45 years) completed three sessions, including a graded exercise test on a cycle ergometer and two counter-balanced mental stress trials. In the mental challenge-control condition (MC), participants sat quietly for 20 min following a 20 min mental challenge whereas in the mental challenge-exercise condition (MEC) subjects cycled at 35% of maximal oxygen consumption (VO(2max)) following the mental challenge. Repeated-measures ANOVAs were used to assess state anxiety (SAI), cardiovascular variables, EPI, NE, and CORT levels across time between conditions. Participants reported significantly greater increases in SAI scores immediately after the mental challenge, which then decreased post-challenge in both conditions. Neither EPI or NE demonstrated an alteration in levels in either condition, but CORT significantly increased after the mental challenge in both conditions and then maintained a significantly greater level during the MEC compared to the MC condition from midexercise through 15 min of recovery. Area-under-the-curve calculations for CORT was significantly greater in the MEC compared to the MC. Results suggest that the initial mental challenge may have acted to enhance the overall adrenal response to the subsequent anticipation of and actual participation in the low-level physical challenge. C1 [Webb, Heather E.] Mississippi State Univ, Dept Kinesiol, Starkville, MS 39759 USA. [Fabianke-Kadue, Emily C.] Univ Mississippi, Dept Hlth Exercise Sci & Recreat Management, Oxford, MS USA. [Kraemer, Robert R.] SE Louisiana Univ, Dept Kinesiol & Hlth Studies, Hammond, LA 70402 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Castracane, V. Daniel] Texas Tech Univ, Hlth Sci Ctr, Sch Med Permian Basin, Dept Obstet & Gynecol, Odessa, TX USA. [Acevedo, Edmund O.] Virginia Commonwealth Univ, Dept Hlth & Human Performance, Richmond, VA USA. RP Webb, HE (reprint author), Mississippi State Univ, Dept Kinesiol, 121 McCarthy Gymnasium, Starkville, MS 39759 USA. EM hwebb@colled.msstate.edu RI Webb, Heather/A-4219-2010 OI Webb, Heather/0000-0002-3925-9613 NR 33 TC 8 Z9 8 U1 0 U2 7 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-0586 J9 APPL PSYCHOPHYS BIOF JI Appl. Psychophysiol. Biofeedback PD DEC PY 2011 VL 36 IS 4 BP 243 EP 250 DI 10.1007/s10484-011-9164-z PG 8 WC Psychology, Clinical SC Psychology GA 852FN UT WOS:000297341100002 PM 21748278 ER PT J AU O'Donnell, JC McDonough, JH Shih, TM AF O'Donnell, John C. McDonough, John H. Shih, Tsung-Ming TI In vivo microdialysis and electroencephalographic activity in freely moving guinea pigs exposed to organophosphorus nerve agents sarin and VX: analysis of acetylcholine and glutamate SO ARCHIVES OF TOXICOLOGY LA English DT Article DE Acetylcholine; Acetylcholinesterase; Choline; Electroencephalogram; gamma-Aminobutylic acid (GABA); Glutamate; Guinea pig; In vivo microdialysis; Nerve agents; Organophosphorus compounds; Sarin; Seizure activity; VX ID SOMAN-INDUCED SEIZURES; EXTRACELLULAR STRIATAL ACETYLCHOLINE; ANTICONVULSANT TREATMENT; CARBOXYLESTERASE INHIBITION; ATROPINE SULFATE; BRAIN; RAT; MECHANISMS; EFFICACY; INTOXICATION AB Organophosphorus nerve agents such as sarin (GB) and VX irreversibly inhibit acetylcholinesterase, causing a buildup of acetylcholine (ACh) in synapses and neuromuscular junctions, which leads to excess bronchial secretions, convulsions, seizures, coma, and death. Understanding the unique toxic characteristics of different nerve agents is vital in the effort to develop broad spectrum medical countermeasures. To this end, we employed a repeated measure multivariate design with striatal microdialysis collection and high-performance liquid chromatography analysis to measure changes in concentrations of several neurotransmitters (ACh, glutamate, aspartate, GABA) in the same samples during acute exposure to GB or VX in freely moving guinea pigs. Concurrent with microdialysis collection, we used cortical electrodes to monitor brain seizure activity. This robust double multivariate design provides greater fidelity when comparing data while also reducing the required number of subjects. No correlation between nerve agents' propensity for causing seizure and seizure-related lethality was observed. The GB seizure group experienced more rapid and severe cholinergic toxicity and lethality than that of the VX seizure group. Seizures generated from GB and VX exposure resulted in further elevation of ACh level and then a gradual return to baseline. Glutamate levels increased in the GB, but not in the VX, seizure group. There were no consistent changes in either aspartate or GABA as a result of either nerve agent. These observations reinforce findings with other nerve agents that seizure activity per se contributes to the elevated levels of brain ACh observed after nerve agent exposure. C1 [O'Donnell, John C.; McDonough, John H.; Shih, Tsung-Ming] USA, Pharmacol Branch, Div Res, Med Res Inst Chem Def ,ATTN MCMR CDR P Dr TM Shih, Aberdeen Proving Ground, MD 21010 USA. RP Shih, TM (reprint author), USA, Pharmacol Branch, Div Res, Med Res Inst Chem Def ,ATTN MCMR CDR P Dr TM Shih, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM tsungming.a.shih@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division FX The authors express their appreciation for the excellent technical assistance of Cindy Acon-Chen, Jeffrey Koenig, and Amy Wegener. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division. Portion of this work was conducted by JCO as a thesis in partial fulfillment of the requirements for the degree of Master of Science in Biology at Towson University, Towson, MD. The opinions or assertions contained herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. NR 40 TC 11 Z9 11 U1 3 U2 12 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD DEC PY 2011 VL 85 IS 12 BP 1607 EP 1616 DI 10.1007/s00204-011-0724-z PG 10 WC Toxicology SC Toxicology GA 852LP UT WOS:000297359700015 PM 21695469 ER PT J AU Rupp, TL Balkin, TJ AF Rupp, Tracy L. Balkin, Thomas J. TI Comparison of Motionlogger Watch and Actiwatch actigraphs to polysomnography for sleep/wake estimation in healthy young adults SO BEHAVIOR RESEARCH METHODS LA English DT Article DE Actigraphy; Polysomnography; Sleep deprivation AB Sleep/wake identification and sleep parameter estimates from Motionlogger Watch and Actiwatch-64 actigraphs were compared to polysomnography (PSG). Following one night of baseline sleep, 29 volunteers remained awake for 36 h, followed by 11 h of recovery sleep in the laboratory. Two sets of analyses were performed: (1) epoch-by-epoch agreement and discriminability index (d') calculations, and (2) sleep parameter concordance with repeated measures ANOVAs. Sensitivity (sleep identification), specificity (wake detection), and overall agreement with PSG, as well as d', were higher for the Motionlogger than for Actiwatch. Relative to PSG, the Actiwatch-estimated total sleep time and sleep efficiency were underestimated and the number of awakenings was overestimated for baseline and recovery; sleep latency was underestimated on the baseline night. On the other hand, the Motionlogger-estimated total sleep time and sleep efficiency estimates were underestimated, and the sleep latency was overestimated on recovery, versus PSG. Despite these misestimations, it was concluded that the Motionlogger provided nominally better agreement with PSG, and that actigraphy generally constitutes a reasonably reliable tool for producing objective measurements of sleep/wake, but that users should remain mindful of its limitations. C1 [Rupp, Tracy L.; Balkin, Thomas J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD 20910 USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM tracy.rupp@amedd.army.mil NR 16 TC 19 Z9 19 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1554-351X J9 BEHAV RES METHODS JI Behav. Res. Methods PD DEC PY 2011 VL 43 IS 4 BP 1152 EP 1160 DI 10.3758/s13428-011-0098-4 PG 9 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA 850BK UT WOS:000297169200022 PM 21512871 ER PT J AU Lindsay, DL Bailey, P Lance, RF Clifford, MJ Delph, R Cobb, NS AF Lindsay, Denise L. Bailey, Pamela Lance, Richard F. Clifford, Michael J. Delph, Robert Cobb, Neil S. TI Effects of a nonnative, invasive lovegrass on Agave palmeri distribution, abundance, and insect pollinator communities SO BIODIVERSITY AND CONSERVATION LA English DT Article DE Agave palmeri; Eragrostis lehmanniana; Fire history; Indicator species; Pollinator community; Network analysis ID ERAGROSTIS-LEHMANNIANA NEES; DESERT GRASSLANDS; NETWORKS; SPREAD; CALIFORNIA; RESPONSES; ARIZONA; GRASSES; CLIMATE; GROWTH AB Nonnative Lehmann lovegrass (Eragrostis lehmanniana) has invaded large areas of the Southwestern United States, and its impact on native plants is not fully understood. Palmer's agave (Agave palmeri), an important resource for many pollinators, is a key native plant potentially threatened by E. lehmanniana. Understanding potential impacts of E. lehmanniana on A. palmeri is critical for anticipating the future of the desert community where they coexist and for addressing management concerns about associated threatened and endangered species. Our study provides strong indications that E. lehmanniana negatively impacts A. palmeri in several ways. Areas of high E. lehmanniana abundance were associated with significantly lower densities and greater relative frequencies of small A. palmeri, suggesting that E. lehmanniana may exclude A. palmeri. There were no significant differences in species richness, abundance, or community composition when comparing flower associates associated with A. palmeri in areas of high and low E. lehmanniana abundance. However, we did find significantly lower connectedness within the pollination network associated with A. palmeri in areas with high E. lehmanniana abundance. Although E. lehmanniana forms thick stands that would presumably increase fire frequency, there was no significant association between E. lehmanniana and fire frequency. Interestingly, medium to high densities of A. palmeri were associated with areas of greater fire frequency. The complex ramifications of E. lehmanniana invasion for the long-lived A. palmeri and interlinked desert community warrant continued study, as these species are likely to continue to be found in close association due to their similar soil preferences. C1 [Lindsay, Denise L.; Bailey, Pamela; Lance, Richard F.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Clifford, Michael J.] Lehigh Univ, Earth & Environm Sci Dept, Bethlehem, PA 18015 USA. [Delph, Robert; Cobb, Neil S.] No Arizona Univ, Dept Biol Sci, Merriam Powell Ctr Environm Res, Flagstaff, AZ 86011 USA. RP Lindsay, DL (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM denise.l.lindsay@usace.army.mil FU Department of Defense Legacy Resource Management (MIPR) [W31RYO80857494]; U.S. Army Engineer Research and Development Center; U.S. Government FX We thank S. Stone, D. Schlichting, P. Landin, S. Langley, G. Pollard, and J. P. Hodnett for their assistance with field efforts and data accumulation. Funding for this project was provided by the Department of Defense Legacy Resource Management Program (MIPR: W31RYO80857494). The study described and the resulting data presented herein were partly obtained from research conducted under the U.S. Army Environmental Quality Technology Program by the U.S. Army Engineer Research and Development Center. Permission was granted by the Chief of Engineers to publish this information. The views expressed in this manuscript are those of the authors' and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government. The use of trade, product, or firm names in this paper is for descriptive purposes only and does not imply endorsement by the U.S. Government. NR 60 TC 4 Z9 4 U1 4 U2 50 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0960-3115 J9 BIODIVERS CONSERV JI Biodivers. Conserv. PD DEC PY 2011 VL 20 IS 13 SI SI BP 3251 EP 3266 DI 10.1007/s10531-011-0133-x PG 16 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 850CB UT WOS:000297170900023 ER PT J AU Petrikovics, I Thompson, DE Rockwood, GA Logue, BA Martin, S Jayanna, P Yu, JCC AF Petrikovics, Ilona Thompson, David E. Rockwood, Gary A. Logue, Brian A. Martin, Sarah Jayanna, Prashanth Yu, Jorn C. C. TI Organ-distribution of the metabolite 2-aminothiazoline-4-carboxylic acid in a rat model following cyanide exposure SO BIOMARKERS LA English DT Article DE Diagnostic biomarker; forensic biomarker; cyanide poisoning; 2-aminothiazoline-4-carboxylic acid (ATCA); LC-MS/MS ID GAS-CHROMATOGRAPHY; FIRE VICTIMS; WHOLE-BLOOD; RAPID QUANTITATION; MASS-SPECTROMETRY; HYDROGEN-CYANIDE; URINE AB The reaction of cyanide (CN-) with cystine to produce 2-aminothiazoline-4-carboxylic acid (ATCA) is one of the independent detoxification pathways of cyanide in biological systems. In this report, in vivo production of ATCA and its distributions in plasma and organs were studied after a subcutaneous sublethal dose of 4 mg/kg body weight potassium cyanide (KCN) administration to rats. At this sublethal dose of KCN, ATCA concentration was not significantly increased in the plasma samples, however, it was found significantly increased in liver samples. These results suggested that ATCA might not be a good diagnostic biomarker in plasma for sublethal cyanide exposure; however, liver could serve as the right organ for the detection of ATCA in post-mortem examinations involving cyanide exposure in military, firefighting, industrial and forensic settings. C1 [Petrikovics, Ilona; Thompson, David E.; Jayanna, Prashanth] Sam Houston State Univ, Dept Chem, Huntsville, TX 77341 USA. [Rockwood, Gary A.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Logue, Brian A.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Martin, Sarah; Yu, Jorn C. C.] Sam Houston State Univ, Master Sci Forens Sci Program, Coll Criminal Justice, Huntsville, TX 77341 USA. RP Petrikovics, I (reprint author), Sam Houston State Univ, Dept Chem, Box 2117,1003 Bowers Blvd, Huntsville, TX 77341 USA. EM ixp004@shsu.edu RI Thompson, David/J-7612-2015; OI Yu, Jorn Chi-Chung/0000-0002-4899-7909 FU National Institutes of Health (NIH: National Institute of Allergy and Infectious Diseases (NIAID)/United States Army Medical Research Institute of Chemical Defense (USAMRICD) Interagency Agreements) [W911NF-07-D-0001]; USAMRICD under US Army Research Office of Scientific Services [TCN 08284]; Robert A. Welch Foundation at Sam Houston State University, Huntsville, TX; Sam Houston State University FX This work was supported by National Institutes of Health (NIH: National Institute of Allergy and Infectious Diseases (NIAID)/United States Army Medical Research Institute of Chemical Defense (USAMRICD) Interagency Agreements) [W911NF-07-D-0001] and the USAMRICD under the auspices of the US Army Research Office of Scientific Services Program administered by Battelle [Delivery order 0557, Contract No TCN 08284], and the Robert A. Welch Foundation at Sam Houston State University, Huntsville, TX. Research supports form the Faculty Enhancement Grants for Research (EGR) from Sam Houston State University was greatly appreciated. NR 30 TC 5 Z9 5 U1 0 U2 9 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1354-750X J9 BIOMARKERS JI Biomarkers PD DEC PY 2011 VL 16 IS 8 BP 686 EP 690 DI 10.3109/1354750X.2011.626528 PG 5 WC Biotechnology & Applied Microbiology; Toxicology SC Biotechnology & Applied Microbiology; Toxicology GA 850UM UT WOS:000297225000009 PM 22023534 ER PT J AU Pankow, M Waas, AM Yen, CF Ghiorse, S AF Pankow, M. Waas, A. M. Yen, C. F. Ghiorse, S. TI Resistance to delamination of 3D woven textile composites evaluated using End Notch Flexure (ENF) tests: Cohesive zone based computational results SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article DE 3-Dimensional reinforcement; Fracture; Impact behavior; Finite element analysis (FEA) ID SPECIMENS; FRACTURE; LAW AB The flexural response of 3D woven textile composite panels containing an edge crack is evaluated using the End Notch Flexure (ENF) test. In doing so, the effectiveness of 3D reinforcement in increasing and/or eliminating delamination is demonstrated. A finite element model of the ENF configuration using the Discrete Cohesive Zone Model (DCZM) was used to evaluate the deformation response and fracture properties corresponding to the experimental results presented in Pankow et al. (2011) [1]. A modified trapezoidal traction law was used in the DCZM to computationally evaluate the ENF test results. Good agreement between experimental results and predictions are reported, up to the point at which the crack reaches under the loading roller and damage begins to occur locally under the roller. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Pankow, M.; Waas, A. M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA. [Yen, C. F.; Ghiorse, S.] USA, Res Labs, Aberdeen, MD USA. RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA. EM dcw@umich.edu FU Army Research Laboratory, Aberdeen Proving Ground, MD FX The authors thank the Army Research Laboratory, Aberdeen Proving Ground, MD, for their continued financial support. NR 15 TC 9 Z9 9 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD DEC PY 2011 VL 42 IS 12 BP 1863 EP 1872 DI 10.1016/j.compositesa.2011.07.028 PG 10 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA 853AG UT WOS:000297398000001 ER PT J AU Carlson, LA Tighe, SW Kenefick, RW Dragon, J Westcott, NW LeClair, RJ AF Carlson, Lara A. Tighe, S. W. Kenefick, R. W. Dragon, J. Westcott, N. W. LeClair, R. J. TI Changes in transcriptional output of human peripheral blood mononuclear cells following resistance exercise SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Microarray; Gene expression; Immune response; Resistance exercise ID HUMAN SKELETAL-MUSCLE; IMMUNE-RESPONSE; GENE-EXPRESSION; ECCENTRIC EXERCISE; CARBOHYDRATE; CYTOKINE; MATRIX-METALLOPROTEINASE-9; GLYCOPROTEIN; ADAPTATION; ARGINASE AB Various types of exercise alter the population of circulating peripheral blood mononuclear cells (PBMCs) and change their transcriptional output. This work examines changes in PBMC populations and transcription in response to resistance exercise training (RET), and identify key transcriptional changes in PBMCs that may play a role in altering peripheral tissues in response to RET. Ten resistance-trained men (20-24 years), performed an acute bout of RET for similar to 30 min following a 12 h fast. Venous blood was sampled at rest, immediately following exercise, and at 2 h post-exercise and analyzed for total and differential leukocytes and global gene expression using Affymetrix Genechips. Results showed elevated leukocytes, monocytes, lymphocytes, and lactate values immediately post-exercise (P < 0.05) over baseline. At 2 h post-exercise, leukocytes, and granulocytes remained elevated (P < 0.05), whereas lymphocytes were lower than (P < 0.05) baseline values. Initial microarray results showed the greatest transcriptional changes in pathways related to immune response, inflammation, and cellular communication. The change in PBMC population (2 h time point) correlated with a dramatic decrease in the expression of CD160, and XCL1, markers of lymphocyte populations. At the 2 h recovery time point upregulation of matrix metalloproteinase 9, orosomucoid 1, dishevelled-associated activator of morphogenesis 2, and arginase 1 suggest an induction in muscle damage and repair during this time frame. These results demonstrate that an acute bout of RET disrupts cellular homeostasis, induces a transient redistribution of certain leukocytes, and results in transcriptional changes in PBMCs translating into systemic changes in response to RET. C1 [Carlson, Lara A.] Univ New England, Westbrook Coll Hlth Profess, Biddeford, ME 04005 USA. [Tighe, S. W.; Dragon, J.] Univ Vermont, Vermont Genet Network, Burlington, VT USA. [Kenefick, R. W.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Westcott, N. W.] Castleton State Coll, Castleton, VT USA. [LeClair, R. J.] Univ New England, Coll Med, Biddeford, ME 04005 USA. RP Carlson, LA (reprint author), Univ New England, Westbrook Coll Hlth Profess, 11 Hills Beach Rd, Biddeford, ME 04005 USA. EM lcarlson@une.edu FU Vermont Genetics Network from the National Center for Research Resources (NCRR), component of the National Institutes of Health (NIH) [P20 RR16462]; University of Vermont (UVM) FX The views, opinions, and findings in this report are those of the authors and should not be construed as official Department of the Army position, policy, or decision unless so designated by other official designation. All experiments were carried out in accordance to state and federal guidelines. This publication was made possible by the Vermont Genetics Network through Grant Number P20 RR16462 from the INBRE Program of the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH. The authors would like to thank all the men who participated in this exercise study, Dr. Jeff Bond for bioinformatics support at the University of Vermont (UVM), and Tim Hunter in the VGN microarray core lab (UVM) for assistance in the experimental design. NR 41 TC 12 Z9 13 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2011 VL 111 IS 12 BP 2919 EP 2929 DI 10.1007/s00421-011-1923-2 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 850DL UT WOS:000297174800004 PM 21437602 ER PT J AU Kenefick, RW Cheuvront, SN Ely, BR Palombo, LJ Sawka, MN AF Kenefick, Robert W. Cheuvront, Samuel N. Ely, Brett R. Palombo, Laura J. Sawka, Michael N. TI DEET insect repellent: effects on thermoregulatory sweating and physiological strain SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE N,N-diethyl-m-toluamide; Heat illness; Thermal sensation; Sweat evaporation ID HEAT-STRESS; EXERCISE; ENVIRONMENTS; RESPONSES; BODY; TEMPERATURE; PERFORMANCE; HYDRATION; MEN AB Insect repellents (e.g. N,N-diethyl-m-toluamide or DEET) applied to the skin can potentially interfere with sweat production and evaporation, thus increasing physiological strain during exercise-heat stress. The purpose was to determine the impact of 33% DEET lotion on sweating responses, whole body thermoregulation and thermal sensation during walking exercise in the heat. Nine volunteers (2 females, 7 males; 22.1 +/- A 4.9 years; 176.4 +/- A 10.0 cm; 79.9 +/- A 12.9 kg) completed 5 days of heat acclimation (45A degrees C, 20% rh; 545 watts; 100 min/day) and performed three trials: control (CON); DEET applied to forearm (DEET(LOC), 12 cm(2)); and DEET applied to similar to 13% body surface area (DEET(WB),). Trials consisted of 30 min walking (645 watts) in 40A degrees C, 20% rh environment. Local sweat rate (SR), onset and skin wettedness were measured in DEET(LOC), and heart rate (HR), rectal temperature (T (re)), skin temperature (T (sk)), RPE, and thermal sensations (TS) were measured during DEET(WB). No differences (p > 0.05) were observed between DEET(LOC) versus CON, respectively, for steady state SR (1.89 +/- A 0.44 vs. 2.09 +/- A 0.84 mg/cm(2)/min), SR area under the curve (46.9 +/- A 11.7 vs. 55.0 +/- A 20.8 mg/cm(2)), sweating onset, or skin wettedness. There were no differences (p > 0.05) in HR, T (re), T (sk), Physiological Strain Index, RPE or TS between DEET(WB) versus CON. DEET did not impact measures of local forearm sweating and when applied according to military doctrine, did not adversely impact physiological responses during exercise-heat stress. DEET can be safely worn during military, occupational and recreational activities in hot, insect infested environments. C1 [Kenefick, Robert W.; Cheuvront, Samuel N.; Ely, Brett R.; Palombo, Laura J.; Sawka, Michael N.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil NR 32 TC 2 Z9 2 U1 2 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2011 VL 111 IS 12 BP 3061 EP 3068 DI 10.1007/s00421-011-1932-1 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 850DL UT WOS:000297174800018 PM 21455616 ER PT J AU O'Brien, C Castellani, JW Sawka, MN AF O'Brien, Catherine Castellani, John W. Sawka, Michael N. TI Thermal face protection delays finger cooling and improves thermal comfort during cold air exposure SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Reflex vasoconstriction; Heat loss; Thermal sensation ID SKIN TEMPERATURE; VASOCONSTRICTOR RESPONSE; AMBIENT-TEMPERATURES; BLOOD-FLOW; EXERCISE; HUMANS; REFLEX; PERFORMANCE; WATER; STIMULATION AB When people dress for cold weather, the face often remains exposed. Facial cooling can decrease finger blood flow, reducing finger temperature (T (f)). This study examined whether thermal face protection limits finger cooling and thereby improves thermal comfort and manual dexterity during prolonged cold exposure. T (f) was measured in ten volunteers dressed in cold-weather clothing as they stood for 60 min facing the wind (-15A degrees C, 3 m s(-1)), once while wearing a balaclava and goggles (BAL), and once with the balaclava pulled down and without goggles (CON). Subjects removed mitts, wearing only thin gloves to perform Purdue Pegboard (PP) tests at 15 and 50 min, and Minnesota Rate of Manipulation (MRM) tests at 30 and 55 min. Subjects rated their thermal sensation and comfort just before the dexterity tests. T (f) decreased (p < 0.05 for time x trial interaction) by 15 min of cold exposure during CON (33.6 +/- A 1.4-28.7 +/- A 2.0A degrees C), but not during BAL (33.2 +/- A 1.4-30.6 +/- A 3.2A degrees C); and after 30 min T (f) remained warmer during BAL (23.3 +/- A 5.9A degrees C) than CON (19.2 +/- A 3.5); however, by 50 min, T (f) was no different between trials (14.1 +/- A 2.7A degrees C). Performance on PP fell (p < 0.05) by 25% after 50 min in both trials; MRM performance was not altered by cold on either trial. Subjects felt colder (p < 0.05) and more uncomfortable (p < 0.05) during CON, compared to BAL. Thermal face protection was effective for maintaining warmer T (f) and thermal comfort during cold exposure; however, local cooling of the hands during manual dexterity tests reduced this physiological advantage, and performance was not improved. C1 [O'Brien, Catherine; Castellani, John W.; Sawka, Michael N.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. RP O'Brien, C (reprint author), USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA. EM kate.obrien@us.army.mil NR 47 TC 0 Z9 0 U1 1 U2 18 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2011 VL 111 IS 12 BP 3097 EP 3105 DI 10.1007/s00421-011-1931-2 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 850DL UT WOS:000297174800022 PM 21461929 ER PT J AU Xu, XJ Gonzalez, J AF Xu, Xiaojiang Gonzalez, Julio TI Determination of the cooling capacity for body ventilation system SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Heat strain; Microclimate cooling; Manikin; Cooling efficiency ID EXERCISE; VEST; HOT; TEMPERATURES; STRAIN; DRY AB Body ventilation systems (BVS) are effective in reducing heat strain, but the amount of heat that a BVS removes from a human body is unclear. The purpose of this study was to propose a method for quantifying BVS cooling capacity using manikin evaluation and modeling. Cooling capacity was calculated as the product of maximum cooling potential and cooling efficiency. The maximum cooling potential is calculated as the difference in enthalpy between the air entering and exiting the BVS where the outlet air temperature is equal to skin temperature with a relative humidity of 100%. The cooling efficiency, defined as a ratio of the cooling capacity to the maximum cooling potential, can be determined through measurements on sweating thermal manikins. A BVS system was evaluated on a manikin with the ventilation fan ON (flow rate 4.7 L/s) or OFF under eleven ambient conditions. The measured cooling efficiencies were 0.31 +/- A 0.02 and almost constant. Using this cooling efficiency, the BVS cooling capacities at various skin temperature and ambient conditions were estimated. This two-step approach can be used to quantify BVS cooling effectiveness during physiology studies. First, the cooling efficiency is determined on sweating thermal manikins. Second, the cooling capacity is calculated from the skin temperature, ambient temperature and relative humidity. However, various factors may reduce the actual cooling provided by the BVS, and the calculated cooling capacity should be considered the upper limit for cooling. C1 [Xu, Xiaojiang; Gonzalez, Julio] USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP Xu, XJ (reprint author), USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, 42 Kansas St, Natick, MA 01760 USA. EM xiaojiang.xu@us.army.mil NR 14 TC 13 Z9 13 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD DEC PY 2011 VL 111 IS 12 BP 3155 EP 3160 DI 10.1007/s00421-011-1941-0 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 850DL UT WOS:000297174800029 PM 21455613 ER PT J AU Wilkinson, DM Blacker, SD Richmond, VL Horner, FE Rayson, MP Spiess, A Knapik, JJ AF Wilkinson, David M. Blacker, Sam D. Richmond, Victoria L. Horner, Fleur E. Rayson, Mark P. Spiess, Anita Knapik, Joseph J. TI Injuries and injury risk factors among British army infantry soldiers during predeployment training SO INJURY PREVENTION LA English DT Article ID PUBLIC-HEALTH APPROACH; PHYSICAL-FITNESS; PREVENTION; MILITARY; PROGRAM; SURVEILLANCE; RECRUITS; RATES; RECOMMENDATIONS; POPULATIONS AB Purpose This prospective cohort study examined injuries and injury risk factors in 660 British Army infantry soldiers during a predeployment training cycle. Methods Soldiers completed a questionnaire concerning physical characteristics, occupational factors, lifestyle characteristics (including physical training time) and previous injury. Direct measurements included height, body mass, sit-ups, push-ups and run time. Electronic medical records were screened for injuries over a 1-year period before operational deployment. Backward-stepping Cox regression calculated HR and 95% CI to quantify independent injury risk factors. Results One or more injuries were experienced by 58.5% of soldiers. The new injury diagnosis rate was 88 injuries/ 100 person-years. Most injuries involved the lower body (71%), especially the lower back (14%), knee (19%) and ankle (15%). Activities associated with injury included sports (22%), physical training (30%) and military training/ work (26%). Traumatic injuries accounted for 83% of all injury diagnoses. Independent risk factors for any injury were younger age (17-19 years (HR 1.0), 20-24 years (HR 0.71, 95% CI 0.55 to 0.93), 25-29 years (HR 0.89, 95% CI 0.66 to 1.19) and 30-43 years (HR 0.41, 95% CI 0.27 to 0.63), previous lower limb injury (yes/no HR 1.49, 95% CI 1.19 to 1.87) and previous lower back injury (yes/no HR 1.30, 95% CI 1.03 to 1.63). Conclusion British infantry injury rates were lower than those reported for US infantry (range 101-223 injuries/ 100 soldier-years), and younger age and previous injury were identified as independent risk factors. Future efforts should target reducing the incidence of traumatic injuries, especially those related to physical training and/or sports. C1 [Wilkinson, David M.; Blacker, Sam D.; Richmond, Victoria L.; Horner, Fleur E.; Rayson, Mark P.] Optimal Performance Ltd, Bristol BS8 2AT, Avon, England. [Spiess, Anita; Knapik, Joseph J.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD USA. RP Wilkinson, DM (reprint author), Optimal Performance Ltd, Coach House,26B Oakfield Rd, Bristol BS8 2AT, Avon, England. EM david@optimalperformance.co.uk FU Human Dimension and Medical Science domain of the Ministry of Defence FX This work was funded by the Human Dimension and Medical Science domain of the Ministry of Defence scientific research programme. NR 35 TC 10 Z9 11 U1 0 U2 13 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 1353-8047 J9 INJURY PREV JI Inj. Prev. PD DEC PY 2011 VL 17 IS 6 BP 381 EP 387 DI 10.1136/ip.2010.028233 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 852QA UT WOS:000297371300006 PM 21507884 ER PT J AU Xing, LD Borodin, O Smith, GD Li, WS AF Xing, Lidan Borodin, Oleg Smith, Grant D. Li, Weishan TI Density Functional Theory Study of the Role of Anions on the Oxidative Decomposition Reaction of Propylene Carbonate SO JOURNAL OF PHYSICAL CHEMISTRY A LA English DT Article ID LITHIUM-ION BATTERIES; SITU FTIR SPECTROSCOPY; THIN-FILM ELECTRODE; ELECTROCHEMICAL OXIDATION; ANODIC STABILITY; LI-ION; POTENTIALS; SURFACE AB The oxidative decomposition mechanism of the lithium battery electrolyte solvent propylene carbonate (PC) with and without PF6- and ClO4- anions has been investigated using the density functional theory at the B3LYP/6-311++G(d) level. Calculations were performed in the gas phase (dielectric constant epsilon = 1) and employing the polarized continuum model with a dielectric constant epsilon = 20.5 to implicitly account for solvent effects. It has been found that the presence of PF6- and ClO4- anions significantly reduces PC oxidation stability, stabilizes the PC-anion oxidation decomposition products, and changes the order of the oxidation decomposition paths. The primary oxidative decomposition products of PC-PF6- and PC-ClO4- were CO2 and acetone radical. Formation of HF and PF5 was observed upon the initial step of PC-PF6- oxidation while HClO4 formed during initial oxidation of PC-ClO4-. The products from the less likely reaction paths included propanal, a polymer with fluorine and fluoro-alkanols for PC-PF6- decomposition, while acetic acid, carboxylic acid anhydrides, and Cl- were found among the decomposition products of PC-ClO4-. The decomposition pathways with the lowest barrier for the oxidized PC-PF6- and PC-ClO4- complexes did not result in the incorporation of the fluorine from PF6- or ClO4- into the most probable reaction products despite anions and HF being involved in the decomposition mechanism; however, the pathway with the second lowest barrier for the PC-PF6- oxidative ring-opening resulted in a formation of fluoro-organic compounds, suggesting that these toxic compounds could form at elevated temperatures under oxidizing conditions. C1 [Borodin, Oleg] USA, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Xing, Lidan; Smith, Grant D.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA. [Xing, Lidan; Li, Weishan] S China Normal Univ, Sch Chem & Environm, Guangzhou 510006, Guangdong, Peoples R China. [Li, Weishan] S China Normal Univ, Guangdong Higher Educ Inst, Key Lab Electrochem Technol Energy Storage & Powe, Guangzhou 510006, Guangdong, Peoples R China. RP Borodin, O (reprint author), USA, Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU Department of Energy through ABR; University of Utah, National Science Foundation of China [DE-AC02-05CH11231, 6838611, NSFC20873046]; University of Utah Center for High Performance Computing DoD [TI-09]; China Scholarship Council (CSC) FX This work is supported by the Department of Energy through an ABR program to ARL and DE-AC02-05CH11231 on PO No. 6838611 to University of Utah, National Science Foundation of China (No. NSFC20873046). Support from the University of Utah Center for High Performance Computing DoD's High Performance Computing Modernization Program's (HPCMP) Technology Insertion 2009 (TI-09) program is greatly acknowledged. L.X. acknowledges the China Scholarship Council (CSC) for financial support. NR 31 TC 56 Z9 60 U1 4 U2 49 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1089-5639 J9 J PHYS CHEM A JI J. Phys. Chem. A PD DEC 1 PY 2011 VL 115 IS 47 BP 13896 EP 13905 DI 10.1021/jp206153n PG 10 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 850LE UT WOS:000297195300020 PM 22004044 ER PT J AU Groom, KL Ramsey, MJ Saunders, JE AF Groom, Kelly L. Ramsey, Mitchell J. Saunders, James E. TI Telehealth and Humanitarian Assistance in Otolaryngology SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Telehealth; Telemedicine; Humanitarian aid; Humanitarian assistance; Otolaryngology AB A significant worldwide need exists for humanitarian assistance in the spacialty of otolaryngology. The field of telehealth has provided applications that have successfully expanded access to care in many fields of medicine, in both developed and developing countries. Collaboration, planning, and persistence are essential to developing successful telehealth applications. This article describes the need for otolaryngologic specialty care, current humanitarian outreach within the field of otolaryngology, and examples of successful programs that incorporate telehealth in otolaryngology care. C1 [Ramsey, Mitchell J.] Tripler Army Med Ctr, Div Otolaryngol, Otolaryngol Serv, Honolulu, HI 96859 USA. [Saunders, James E.] Dartmouth Med Ctr, Dept Otolaryngol, Lebanon, NH 03756 USA. RP Ramsey, MJ (reprint author), Tripler Army Med Ctr, Div Otolaryngol, Otolaryngol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM mitchell.ramsey@us.army.mil NR 14 TC 2 Z9 3 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2011 VL 44 IS 6 BP 1251 EP + DI 10.1016/j.otc.2011.08.002 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 852ZV UT WOS:000297396900003 PM 22032479 ER PT J AU Mashima, PA Brown, JE AF Mashima, Pauline A. Brown, Janet E. TI Remote Management of Voice and Swallowing Disorders SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Telehealth; Telepractice; Telerehabilitation; Speech-language pathology; Voice disorders; Dysphonia; Swallowing disorders; Dysphagia ID NEUROGENIC COMMUNICATION DISORDERS; SPEECH-LANGUAGE THERAPY; PARKINSONS-DISEASE; TELEREHABILITATION SYSTEM; ADULTS; TELEHEALTH; TELEMEDICINE; PATHOLOGY; INTERNET; OTOLARYNGOLOGY AB Telehealth or telepractice can alleviate shortages of speech-language pathologists, particularly in rural and underserved areas, where specialists in voice and swallowing disorders may not be available. In addition to improving access to services, telehealth offers the opportunity for patients to receive care in their natural environment, as in the case of home health care where treatment can include family members and caregivers. This article presents an overview of telehealth applications in the remote management of voice and swallowing disorders including historical background, current issues, and a brief review of clinical effectiveness studies. C1 [Mashima, Pauline A.] Tripler Army Med Ctr, Otolaryngol Serv, Speech Pathol Sect, Honolulu, HI 96859 USA. [Mashima, Pauline A.] Univ Hawaii Manoa, Dept Commun Sci & Disorders, Honolulu, HI 96822 USA. [Brown, Janet E.] Amer Speech Language Hearing Assoc, Hlth Care Serv Speech Language Pathol, Rockville, MD 20850 USA. RP Mashima, PA (reprint author), Tripler Army Med Ctr, Otolaryngol Serv, Speech Pathol Sect, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM pauline.mashima@amedd.army.mil NR 54 TC 4 Z9 4 U1 1 U2 19 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2011 VL 44 IS 6 BP 1305 EP + DI 10.1016/j.otc.2011.08.007 PG 13 WC Otorhinolaryngology SC Otorhinolaryngology GA 852ZV UT WOS:000297396900008 PM 22032484 ER PT J AU Kenyon, JI Poropatich, R Holtel, MR AF Kenyon, Jessica I. Poropatich, Ronald Holtel, Michael R. TI Cell Phones in Telehealth and Otolaryngology SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Mobile health technologies; Remote monitoring; Telemedicine; Remote data collection; Cell phone health applications ID MOBILE PHONE; EMERGENCY; TRIAL AB The worldwide prevalence of mobile phones makes them a powerful platform for providing individualized health care delivered at the patient's convenience. They have the potential to extend the health care interaction from a brief office visit to a continuous monitoring via body sensors of either a specific healthcare parameter or with multiple sensors in wireless body area networks. Remote data collection by way of mobile phones in underserved areas allows for better management of public health and provides the opportunity for timely intervention. Published data showing benefits specific to otolaryngology are primarily in remote consultation, body sensors specific to balance, and appointment compliance. C1 [Kenyon, Jessica I.] USA, TATRC, W Coast Satellite Off, Med Res & Mat Command, Marina Del Rey, CA 90292 USA. [Poropatich, Ronald] USA, TATRC, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Holtel, Michael R.] USA, TATRC, Med Res & Mat Command, San Diego, CA 92106 USA. RP Holtel, MR (reprint author), Sharp Rees Stealy, 10670 Wexford St, San Diego, CA 92131 USA. EM mholtel@hawaii.edu RI Emchi, Karma/Q-1952-2016 NR 19 TC 6 Z9 6 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0030-6665 EI 1557-8259 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 2011 VL 44 IS 6 BP 1351 EP + DI 10.1016/j.otc.2011.08.013 PG 9 WC Otorhinolaryngology SC Otorhinolaryngology GA 852ZV UT WOS:000297396900011 PM 22032487 ER PT J AU Kim, C McGlynn, KA McCorkle, R Erickson, RL Niebuhr, DW Ma, SG Graubard, B Aschebrook-Kilfoy, B Barry, KH Zhang, YW AF Kim, Christopher McGlynn, Katherine A. McCorkle, Ruth Erickson, Ralph L. Niebuhr, David W. Ma, Shuangge Graubard, Barry Aschebrook-Kilfoy, Briseis Barry, Kathryn Hughes Zhang, Yawei TI Quality of life among testicular cancer survivors: a case-control study in the United States SO QUALITY OF LIFE RESEARCH LA English DT Article DE Health status; Quality of life; Testicular cancer ID LONG-TERM SURVIVORS; GENERIC OUTCOME MEASURE; HEALTH SURVEY SF-36; GERM-CELL TUMORS; CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; CLINICAL-TRIALS; POPULATION; TOXICITY; STRESS AB Evidence from previous studies has suggested there may be physical and mental changes in health among testicular cancer survivors. No studies have been conducted in the United States, however. Study participants were initially enrolled in the US Servicemen's Testicular Tumor Environmental and Endocrine Determinants (STEED) study between 2002 and 2005. A total of 246 TGCT (testicular germ cell tumor) cases and 236 non-testicular cancer controls participated in the current study, and completed a self-administered questionnaire. Mean time since diagnosis for cases was 14 years, and no less than five for all cases. Component scores determined from responses to questions about physical and mental health on SF36 were tabulated to yield two summary measures, physical component scores (PCS), and mental component scores (MCS). Component and summary scores were normalized to a score of 50 with a standard deviation of 10 by a linear T-score transformation. Overall, cases may not suffer greatly in different quality of life than controls. When all cases and controls are compared, TGCT cases had lower PCS (mean: 51.9 95% CI: 50.6-53.2, P value: 0.037) than controls (mean: 53.6 95% CI: 52.7-54.6). MCS were not significantly different (P value: 0.091). In multivariate analyses, several physical health components were worse for TGCT cases such as role-physical (OR 1.19, 95% CI: 1.01-1.39) and general health (OR 1.26, 95% CI: 1.07-1.49) compared to controls. However, TGCT cases treated with chemotherapy had lower PCS (cases: 50.2, 95% CI: 47.6-52.8; controls: 53.6, 95% CI: 52.7-54.6, P value: 0.0032) and MCS (cases: 49.3, 95% CI: 46.5-52.1; controls: 52.0, 95% CI: 50.9-53.2, P value: 0.039). TGCT cases who received treatments other than chemotherapy did not differ from controls in either PCS or MCS. Physical and general health limitations may affect testicular cancer survivors. Men treated with chemotherapy, however, may be most likely to suffer adverse health outcomes due to a combination of body-wide effects on physical and mental factors which affect various aspects of physical health, mental health, and overall quality of life. And in particular, physical functioning, role-physical, and general health are strongly affected. C1 [Kim, Christopher; Ma, Shuangge; Barry, Kathryn Hughes; Zhang, Yawei] Yale Univ, Yale Sch Publ Hlth, New Haven, CT 06520 USA. [McGlynn, Katherine A.; Graubard, Barry; Aschebrook-Kilfoy, Briseis; Barry, Kathryn Hughes] NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA. [McCorkle, Ruth] Yale Univ, Yale Sch Nursing, New Haven, CT 06520 USA. [Erickson, Ralph L.; Niebuhr, David W.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Zhang, YW (reprint author), Yale Univ, Yale Sch Publ Hlth, 60 Coll St,LEPH 440, New Haven, CT 06520 USA. EM yawei.zhang@yale.edu RI Aschebrook-Kilfoy, Briseis/A-2537-2012 FU National Cancer Institute (NCI) [CA130110, CA105666]; National Institute of Health (NIH) [1D43TW008323-01, 1D43TW007864-01]; CTSA from the National Center for Research Resources (NCRR), NIH [UL1 RR024139]; NHL roadmap for medical Research FX This study is supported by grants CA130110 and CA105666 from the National Cancer Institute (NCI) and by Fogarty training grants 1D43TW008323-01 and 1D43TW007864-01 from the National Institute of Health (NIH). This publication was made possible by CTSA Grant number UL1 RR024139 from the National Center for Research Resources (NCRR), a component of the NIH and NHL roadmap for medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR. The authors are greatly indebted to the Study participants, without whom, there would have been no study. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. NR 35 TC 14 Z9 15 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0962-9343 J9 QUAL LIFE RES JI Qual. Life Res. PD DEC PY 2011 VL 20 IS 10 BP 1629 EP 1637 DI 10.1007/s11136-011-9907-6 PG 9 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 852HK UT WOS:000297348200011 PM 21499930 ER PT J AU Burkus, JK Gornet, MF Glassman, SD Slosar, PJ Rosner, MK Deckey, JE Nowak, J Hatcher, BM AF Burkus, J. Kenneth Gornet, Matthew F. Glassman, Steven D. Slosar, Paul J. Rosner, Michael K. Deckey, Jeffrey E. Nowak, John Hatcher, Brian M. TI Blood Serum Antibody Analysis and Long-Term Follow-up of Patients Treated With Recombinant Human Bone Morphogenetic Protein-2 in the Lumbar Spine SO SPINE LA English DT Article DE antibody formation; bone morphogenetic protein; BMP-2; degenerative disc disease; INFUSE Bone Graft; lumbar spine; lumbar fusion; spinal arthrodesis ID HER2-POSITIVE BREAST-CANCER; ILIAC CREST AUTOGRAFT; RADIOGRAPHIC OUTCOMES; ADJUVANT CHEMOTHERAPY; TIBIAL FRACTURES; CONTROLLED-TRIAL; FUSION; ARTHRODESIS; RHBMP-2; REPLACEMENT AB Study Design. Prospective, longitudinal cohort study. Objective. To examine the incidence of bone morphogenetic protein (BMP)-2 antibody formation in lumbar spine applications and to determine the clinical significance of an antibody response. Summary of Background Data. Immune responses can affect the safety and efficacy profile of recombinant proteins. Type, incidence, and time course of antibody formation were evaluated in clinical studies investigating recombinant human bone morphogenetic protein (rhBMP)-2 in spinal arthrodesis. Methods. Analysis of antibody formation to BMP-2, bovine collagen, and human collagen was performed after three prospective clinical studies investigating rhBMP-2 in single-level lumbar spinal arthrodesis. Two studies investigated rhBMP-2 applied to an absorbable collagen sponge at 1.5 mg/cm3 in lumbar interbody fusion (n = 449); one study investigated rhBMP-2 applied to a ceramic and collagen compression-resistant matrix at 2.0 mg/cm3 in instrumented posterolateral fusion (n = 239). Control patients received iliac crest bone graft (n = 360). Two validated enzyme-linked immunosorbent assays were used to test for BMP-2 antibodies. Neutralizing antibodies were assessed using a cell bioassay. The incidence of antibodies to bovine and human collagen was determined. Radiographic and clinical outcome data were assessed to determine whether antibodies were correlated to patient outcomes. Results. BMP-2 antibody rates ranged from 0.8% to 6.4% in rhBMP-2 patients and from 0% to 2.3% in control patients. Formation of BMP-2 antibodies peaked within the first 3 months and returned toward baseline values by 12 months. No neutralizing antibodies were detected. Bovine collagen antibody rates ranged from 12.7% to 18.8% in the rhBMP-2 patients and from 12.9% to 21.2% in the control patients. No antibodies to human collagen were detected. Adverse event rates were similar in antibody-positive and antibody-negative patients. BMP-2 antibodies did not affect bridging bone rates. Conclusion. Formation of anti-BMP-2 antibodies was low and transient. No neutralizing antibodies were observed. Formation of antibodies did not affect fusion success or appear to have clinical sequelae. C1 [Burkus, J. Kenneth] Hughston Clin, Columbus, GA 31909 USA. [Gornet, Matthew F.] Orthoped Ctr St Louis, Chesterfield, MO USA. [Slosar, Paul J.] SpineCare Med Grp, Daly City, CA USA. [Glassman, Steven D.] Spine Inst, Louisville, KY USA. [Rosner, Michael K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Deckey, Jeffrey E.] Orthopaed Specialty Inst Med Grp Orange Cty, Orange, CA USA. [Nowak, John] Pfizer Inc, Pharmacokinet Dynam & Metab, Andover, MA USA. [Hatcher, Brian M.] Medtron Spinal & Biol, Memphis, TN USA. RP Burkus, JK (reprint author), Hughston Clin, 6262 Vet Pkwy, Columbus, GA 31909 USA. EM JKB66@knology.net FU Medtronic Spinal Biologics FX Supported by the Medtronic Spinal Biologics, which sponsored this investigation. Six of the authors are consultants and clinical investigators for Medtronic, one is an employee of Pfizer, and one was an employee of Medtronic at the time of submission. NR 43 TC 8 Z9 8 U1 2 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD DEC 1 PY 2011 VL 36 IS 25 BP 2158 EP 2167 DI 10.1097/BRS.0b013e3182059a8c PG 10 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 851LB UT WOS:000297270000017 PM 21325990 ER PT J AU Bedno, SA Soltis, MA Mancuso, JD Burnett, DG Mallon, TM AF Bedno, Sheryl A. Soltis, Michele A. Mancuso, James D. Burnett, Daniel G. Mallon, Timothy M. TI The In-Service Examination Score As a Predictor of Success on the American Board of Preventive Medicine Certification Examination SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID TRAINING EXAMINATION; PART-I; STEP-1 SCORES; PERFORMANCE; PSYCHIATRY; GYNECOLOGY; OBSTETRICS; PEDIATRICS; PASSAGE; USMLE AB Background: To date, there has been no study correlating the American College of Preventive Medicine (ACPM) in-service exam (ISE) with the American Board of Preventive Medicine (ABPM) certification exam. Purpose: To validate the ACPM ISE as a predictor of success on the ABPM certification exam. Methods: ISE and ABPM certification exam scores were standardized by year using z-scores. The correlation between practicum year ISE scores and certification exam scores for military preventive medicine residencies in the National Capital and Washington State areas (core component only) was analyzed. A multivariable linear regression model included adjustments for age, gender, Master of Public Health grade point average (GPA), prior specialty board certification, and board deferral >= 1 year after graduation. Data were collected in 2010 and analyzed in 2011. Results: Performance on the ISE was correlated with performance on the ABPM certification core exam (r=0.61, p<0.001). Performance on the ISE was still significant after adjusting for relevant demographic and educational variables (p<0.001). Other significant covariates included GPA (p=0.001) and board deferral (p=0.04) in the linear regression model. Conclusions: Performance on the ISE is moderately correlated with performance on the board certification core exam, and this correlation remained significant after adjustment in the linear regression model. These results serve to validate the ISE as a means for program directors to identify residents at academic risk and as encouragement for residents to take the certification exam as soon as possible after graduation. (Am J Prev Med 2011;41(6):641-644) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Dept Prevent Med, Ft Gordon, GA 30905 USA. [Soltis, Michele A.] Madigan Army Med Ctr, Dept Prevent Med, Tacoma, WA 98431 USA. [Mancuso, James D.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. [Burnett, Daniel G.; Mallon, Timothy M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Bedno, SA (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Prevent Med, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM sheryl.ann.bedno@us.army.mil NR 14 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD DEC PY 2011 VL 41 IS 6 BP 641 EP 644 DI 10.1016/j.amepre.2011.08.008 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 849US UT WOS:000297151400014 PM 22099243 ER PT J AU Batchinsky, AI Chung, KK Cannon, JW Cancio, LC AF Batchinsky, Andriy I. Chung, Kevin K. Cannon, Jeremy W. Cancio, Leopoldo C. TI Respiratory dialysis is not extracorporeal membrane oxygenation reply SO CRITICAL CARE MEDICINE LA English DT Letter ID MECHANICAL VENTILATION; CO2 REMOVAL C1 [Batchinsky, Andriy I.; Chung, Kevin K.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cannon, Jeremy W.] Brooke Army Med Ctr, Div Trauma & Acute Care Surg, Ft Sam Houston, TX 78234 USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 5 TC 2 Z9 2 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 2011 VL 39 IS 12 BP 2788 EP 2789 DI 10.1097/CCM.0b013e318232cebe PG 2 WC Critical Care Medicine SC General & Internal Medicine GA 851FO UT WOS:000297254000051 ER PT J AU Wenke, JC Guelcher, SA AF Wenke, Joseph C. Guelcher, Scott A. TI Dual delivery of an antibiotic and a growth factor addresses both the microbiological and biological challenges of contaminated bone fractures SO EXPERT OPINION ON DRUG DELIVERY LA English DT Review DE antibiotic; bone; bone morphogenetic protein; dual purpose; graft; growth factor; infection; scaffold; tissue engineering ID OPEN TIBIAL FRACTURES; LOWER-EXTREMITY TRAUMA; IN-VITRO RELEASE; SILICA SOL-GEL; MORPHOGENETIC PROTEIN-2; DRUG-DELIVERY; SEGMENTAL DEFECT; POTENTIAL TREATMENT; EXPERIMENTAL-MODEL; SUSTAINED-RELEASE AB Introduction: Open fractures are plagued by high complication rates, among which infection and nonunion are the most common, leading to higher morbidity and poor patient outcomes. Despite meticulous surgical care and employment of adjunctive therapies, infection rates remain at 20%, due to the limitations of conventional therapies. Areas covered: Persistent bacteria often survive initial debridement and treatment with antibiotics. Thus, the bone graft subsequently implanted to promote healing can be the nidus for infection. The principles of biofilm theory and the "race to the surface" have been applied to develop dual-purpose bone grafts that are protected by a sustained release of an antibiotic, thereby preventing bacterial colonization. A simultaneous sustained release of a recombinant human growth factor allows the defect to become vascularized and heal. Expert opinion: Current therapies fail to meet the challenges of open fractures. Tissue engineering and drug delivery approaches can address the challenges of healing large bone defects while protecting the implant from infection. When combined as an adjunctive therapy with existing clinical practices for management of open fractures, dual-purpose bone grafts that release both an antibiotic and a growth factor at biologically relevant time scales can potentially reduce infection rates and improve patient outcomes. C1 [Wenke, Joseph C.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA. [Guelcher, Scott A.] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA. [Guelcher, Scott A.] Vanderbilt Univ, Med Ctr, Ctr Bone Biol, Nashville, TN 37235 USA. RP Wenke, JC (reprint author), USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM joseph.wenke@us.army.mil; scott.guelcher@vanderbilt.edu FU Orthopedic Extremity Trauma Research Program (DoD) [W81XWH-07-1-0211] FX The development of the dual-purpose graft was funded by the Orthopedic Extremity Trauma Research Program (DoD Grant #W81XWH-07-1-0211). S Guelcher is a consultant for Medtronic, which has licensed aspects of the technology from Vanderbilt. J Wenke has nothing to declare. The opinions or assertions contained herein are the private views of the author and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 121 TC 28 Z9 28 U1 3 U2 23 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 1742-5247 J9 EXPERT OPIN DRUG DEL JI Expert Opin. Drug Deliv. PD DEC PY 2011 VL 8 IS 12 BP 1555 EP 1569 DI 10.1517/17425247.2011.628655 PG 15 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 850UH UT WOS:000297224500003 PM 22017669 ER PT J AU McKenna, SP Parkman, KB Perren, LJ McKenna, JR AF McKenna, Sean P. Parkman, Kevin B. Perren, Lee J. McKenna, Jason R. TI Response of an Electromagnetic Gradiometer to a Subsurface Wire SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Buried object detection; electromagnetic induction (EMI); geophysical measurements; gradient methods ID TUNNEL DETECTION; FREQUENCY; CONDUCTOR; INDUCTION; EXCITATION; TARGETS; OBJECTS; RADAR AB The response of an electromagnetic gradiometer (EMG) system to a subsurface wire is analyzed in terms of experimental and analytical modeling results. Our objective is to explore characteristics of the response and assess the fidelity of our model. The EMG system consists of a static transmitter and a man-portable sensor, which uses a pair of receivers that yield a gradiometric measurement. Experimental results were collected over a range of wire depths from 3.4 to 8.5 m. A number of different transmitter positions were explored, and the tests studied were conducted at 200 kHz. Modeling results were consistent with the experimental results and supported a number of key findings. Results are presented showing that, in order to maximize the strength of the wire response, the transmitter should be positioned approximately 5 m off the wire axis. Furthermore, in order to avoid unwanted transmitter influence on the response, the EMG should be at least 30 m from the transmitter. Using the experimental and modeling results, we found a linear relationship between the width of the magnitude response peak and the wire depth. Based on our experimental results, the EMG is able to yield a discernible target response at a depth of at least 7 m. Lastly, an example of how the model can be used to optimize survey planning is presented. This paper illustrates how an EMG can be used to locate underground wires with applications ranging from underground utility mapping to the detection of shallow subsurface tunnels. C1 [McKenna, Sean P.] Riverside Res, Lexington, MA 02421 USA. [Parkman, Kevin B.; McKenna, Jason R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Perren, Lee J.] Bevilacqua Res Corp, Huntsville, AL 35805 USA. RP McKenna, SP (reprint author), Riverside Res, Lexington, MA 02421 USA. EM smckenna@riversideresearch.org; Kevin.B.Parkman@usace.army.mil; Lee.J.Perren@usace.army.mil; jason.r.mckenna@usace.army.mil FU U.S. Army Engineer Research and Development Center FX This work was supported by the U.S. Army Engineer Research and Development Center under the Rapid Reaction Tunnel Detection Program. NR 30 TC 4 Z9 4 U1 2 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0196-2892 EI 1558-0644 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD DEC PY 2011 VL 49 IS 12 SI SI BP 4944 EP 4953 DI 10.1109/TGRS.2011.2151867 PN 1 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 851OU UT WOS:000297281500025 ER PT J AU O'Connor, FG Deuster, PA Davis, J Pappas, CG Knapik, JJ AF O'Connor, Francis G. Deuster, Patricia A. Davis, Jennifer Pappas, Chris G. Knapik, Joseph J. TI Functional Movement Screening: Predicting Injuries in Officer Candidates SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE INJURY PREVENTION; MILITARY PERSONNEL; PHYSICAL FITNESS; PHYSICAL ACTIVITY ID TRAINING-RELATED INJURIES; CORE STABILITY; RISK-FACTORS; SURVEILLANCE AB O'CONNOR, F. G., P. A. DEUSTER, J. DAVIS, C. G. PAPPAS, and J. J. KNAPIK. Functional Movement Screening: Predicting Injuries in Officer Candidates. Med. Sci. Sports Exerc., Vol. 43, No. 12, pp. 2224-2230, 2011. Purpose: Functional movement screening (FMS) is a musculoskeletal assessment method that incorporates seven movements and yields an overall score based on movement quality. The objectives of this study were to document the distribution of scores and to determine whether FMS scores could predict injury in a large military cohort. Methods: A cohort of 874 Marine officer candidates were recruited, consented, completed demographic questionnaires, and had FMS performed during medical in-processing. Candidates were enrolled in either long-cycle (LC: 68 d; n = 427) or short-cycle (SC: 38 d; n = 447) training and followed up for injuries occurring in training. Results: The mean FMS score (score range = 0-21) among all candidates was 16.6 +/- 1.7; approximately 10% of candidates had FMS scores <= 14. A score of <= 14 on the FMS predicted any injury with a sensitivity of 0.45 and a specificity of 0.71 and serious injury with a sensitivity of 0.12 and a specificity of 0.94. Both LC and SC cohorts demonstrated higher injury risk among candidates who had scores <= 14 compared with those with scores >14 (LC: risk ratio (RR) = 1.65, 95% confidence interval = 1.05-2.59, P = 0.03; SC: RR = 1.91, 95% confidence interval = 1.21-3.01, P < 0.01). Overall, 79.8% of persons with scores <= 14 were in the group with fitness scores <280 (/300), whereas only 6.6% of candidates in the group with fitness scores >= 280 had scores <= 14. Conclusions: This was the first large-scale study performed in an active-duty military cohort to examine the utility of FMS during medical in-processing. Further work is warranted to evaluate FMS and the potential for injury prediction and prevention. C1 [O'Connor, Francis G.; Deuster, Patricia A.; Davis, Jennifer] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [Pappas, Chris G.] Womack Army Community Hosp, Dept Family Med, Ft Bragg, NC USA. [Knapik, Joseph J.] Publ Hlth Command Prov, Aberdeen Proving Ground, MD USA. RP O'Connor, FG (reprint author), Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM foconnor@usuhs.mil RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 FU American Medical Society for Sports Medicine FX The authors acknowledge that this research was performed under a research grant award from the American Medical Society for Sports Medicine. NR 33 TC 65 Z9 66 U1 3 U2 52 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD DEC PY 2011 VL 43 IS 12 BP 2224 EP 2230 DI 10.1249/MSS.0b013e318223522d PG 7 WC Sport Sciences SC Sport Sciences GA 851EL UT WOS:000297251100002 PM 21606876 ER PT J AU Hamed, AM Shabana, AA Jayakumar, P Letherwood, MD AF Hamed, Ashraf M. Shabana, Ahmed A. Jayakumar, Paramsothy Letherwood, Michael D. TI Nonstructural geometric discontinuities in finite element/multibody system analysis SO NONLINEAR DYNAMICS LA English DT Article DE Geometric discontinuities; Finite element; Multibody systems; B-spline; NURBS ID NODAL COORDINATE FORMULATION; FLEXIBLE MULTIBODY SYSTEMS; BEAM ELEMENTS; IMPLEMENTATION; DEFORMATION; PLATE AB Existing multibody system (MBS) algorithms treat articulated system components that are not rigidly connected as separate bodies connected by joints that are governed by nonlinear algebraic equations. As a consequence, these MBS algorithms lead to a highly nonlinear system of coupled differential and algebraic equations. Existing finite element (FE) algorithms, on the other hand, do not lead to a constant mesh inertia matrix in the case of arbitrarily large relative rigid body rotations. In this paper, new FE/MBS meshes that employ linear connectivity conditions and allow for arbitrarily large rigid body displacements between the finite elements are introduced. The large displacement FE absolute nodal coordinate formulation (ANCF) is used to obtain linear element connectivity conditions in the case of large relative rotations between the finite elements of a mesh. It is shown in this paper that a linear formulation of pin (revolute) joints that allow for finite relative rotations between two elements connected by the joint can be systematically obtained using ANCF finite elements. The algebraic joint constraint equations, which can be introduced at a preprocessing stage to efficiently eliminate redundant position coordinates, allow for deformation modes at the pin joint definition point, and therefore, this new joint formulation can be considered as a generalization of the pin joint formulation used in rigid MBS analysis. The new pin joint deformation modes that are the result of C (0) continuity conditions, allow for the calculations of the pin joint strains which can be discontinuous as the result of the finite relative rotation between the elements. This type of discontinuity is referred to in this paper as nonstructural discontinuity in order to distinguish it from the case of structural discontinuity in which the elements are rigidly connected. Because ANCF finite elements lead to a constant mass matrix, an identity generalized mass matrix can be obtained for the FE mesh despite the fact that the finite elements of the mesh are not rigidly connected. The relationship between the nonrational ANCF finite elements and the B-spline representation is used to shed light on the potential of using ANCF as the basis for the integration of computer aided design and analysis (I-CAD-A). When cubic interpolation is used in the FE/ANCF representation, C (0) continuity is equivalent to a knot multiplicity of three when computational geometry methods such as B-splines are used. C (2) ANCF models which ensure the continuity of the curvature and correspond to B-spline knot multiplicity of one can also be obtained. Nonetheless, B-spline and NURBS representations cannot be used to effectively model T-junctions that can be systematically modeled using ANCF finite elements which employ gradient coordinates that can be conveniently used to define element orientations in the reference configuration. Numerical results are presented in order to demonstrate the use of the new formulation in developing new chain models. C1 [Hamed, Ashraf M.; Shabana, Ahmed A.] Univ Illinois, Dept Mech & Ind Engn, Chicago, IL 60607 USA. [Jayakumar, Paramsothy; Letherwood, Michael D.] USA, RDECOM TARDEC, Warren, MI 48397 USA. RP Shabana, AA (reprint author), Univ Illinois, Dept Mech & Ind Engn, 842 W Taylor St, Chicago, IL 60607 USA. EM shabana@uic.edu FU US Army Tank-Automotive Research, Development and Engineering Center (TARDEC) [W911NF-07-D-0001]; National Science Foundation [0808399] FX This research was supported by the US Army Tank-Automotive Research, Development and Engineering Center (TARDEC) (Contract # W911NF-07-D-0001), and, in part, by the National Science Foundation Office of International Programs (Project # 0808399). NR 23 TC 11 Z9 11 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0924-090X J9 NONLINEAR DYNAM JI Nonlinear Dyn. PD DEC PY 2011 VL 66 IS 4 BP 809 EP 824 DI 10.1007/s11071-011-9953-1 PG 16 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 850CJ UT WOS:000297171700029 ER PT J AU Elyassi, AR Helling, ER Closmann, JJ AF Elyassi, Ali R. Helling, Eric R. Closmann, James J. TI Closure of difficult palatal fistulas using a "parachuting and anchoring" technique with the tongue flap SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY LA English DT Article ID REPAIR; DEFECTS AB The tongue flap has been described in reconstructing palatal defects. Nevertheless, properly securing the flap to the palatal defect has continued to pose a challenge, especially because the flap becomes mobile with normal activities (i.e., speech and swallow). For this reason, alternative fixation schemes have been discussed in literature, but do not always solve the problem. In this article, we offer an alternative method for positioning and securing the tongue flap into the palatal defect. The authors of this article believe that advantages of this technique include an increase in flap security and immobility and a decrease in postoperative maxillomandibular fixation requirement. Although unanswered questions still remain regarding improved flap retention with this method, we believe that the "parachuting and anchoring" technique provides an alternative method that can most definitely add to the surgeon's armamentarium. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:711-714) C1 [Elyassi, Ali R.; Closmann, James J.] Tripler Army Med Ctr, Dept Oral & Maxillofacial Surg, Honolulu, HI 96818 USA. [Helling, Eric R.] Tripler Army Med Ctr, Dept Plast Surg, Honolulu, HI 96818 USA. RP Elyassi, AR (reprint author), Tripler Army Med Ctr, Dept Oral & Maxillofacial Surg, 3075 Ala Poha Pl,Suite 2112, Honolulu, HI 96818 USA. EM aelyassi@gmail.com NR 14 TC 6 Z9 6 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD DEC PY 2011 VL 112 IS 6 BP 711 EP 714 DI 10.1016/j.tripleo.2010.12.022 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 851DP UT WOS:000297248900034 PM 21439863 ER PT J AU Khemawoot, P Saunders, D Rasameesoraj, M Melendez, V Imerbsin, R Ohrt, C Fracisco, S Teja-Isavadharm, P AF Khemawoot, Phisit Saunders, David Rasameesoraj, Maneerat Melendez, Victor Imerbsin, Rawiwan Ohrt, Colin Fracisco, Susan Teja-isavadharm, Paktiya TI Absolute Bioavailability of cis-Mirincamycin and trans-Mirincamycin in Healthy Rhesus Monkeys and Ex Vivo Antimalarial Activity against Plasmodium falciparum SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CLINDAMYCIN; LINCOMYCIN; DERIVATIVES; PRIMAQUINE; BIOASSAY; PLASMA; SERUM AB The pharmacokinetics, oral bioavailability, and ex vivo antimalarial activity of mirincamycin isomers in a healthy rhesus monkey model were assessed to support lead optimization of novel nonhemolytic drugs for radical cure and causal prophylaxis of malaria. Fourteen male rhesus monkeys were randomized to four groups, which included cis and trans isomers by the oral and intravenous routes, with vehicle-only controls for each dosing route. Concentration-time data were collected for 7 days and were analyzed by noncompartmental analysis. cis-Mirincamycin had an absolute oral bioavailability of 13.6%, which was slightly higher than that of trans-mirincamycin (11.7%), but this difference was not statistically significant. There was a statistically significant difference between the area under the concentration-time curve from zero to 48 h (AUC(0-48)) of cis-mirincamycin and that of trans-mirincamycin after oral dosing. When cultured in vitro with the W2 clone of Plasmodium falciparum, the 50% inhibitory concentrations for cis-mirincamycin, trans-mirincamycin, and dihydroartemisinin were 11,300, 12,300, and 2.30 nM, respectively. However, when dosed primate plasma was cultured ex vivo against the W2 clone, both isomers had much greater relative potencies than their in vitro activities relative to results for dihydroartemisinin, an increase of approximately 100-fold for the cis isomer and 150-fold for the trans isomer. Further, oral ex vivo activity was significantly higher than intravenous activity for both isomers, particularly during the first 90 min following dosing, suggesting the first-pass formation of one or more metabolites with blood-stage antimalarial activity. Identification of the metabolic pathways and metabolites may help to further delineate the properties of this class of drugs with previously demonstrated liver-stage antimalarial activity. C1 [Khemawoot, Phisit; Saunders, David; Rasameesoraj, Maneerat; Imerbsin, Rawiwan; Teja-isavadharm, Paktiya] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. [Melendez, Victor; Ohrt, Colin; Fracisco, Susan] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP Saunders, D (reprint author), AFRIMS, Dept Immunol & Med, Phyathai Bangkok 10400, Thailand. EM david.saunders@afrims.org FU U.S. Army Research and Materiel Command; Medicines for Malaria Venture (MMV) FX This study was supported by the U.S. Army Research and Materiel Command and the Medicines for Malaria Venture (MMV). NR 24 TC 3 Z9 3 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD DEC PY 2011 VL 55 IS 12 BP 5881 EP 5886 DI 10.1128/AAC.01619-10 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 846RJ UT WOS:000296920600061 PM 21947400 ER PT J AU Cooper, DB Nelson, L Armistead-Jehle, P Bowles, AO AF Cooper, Douglas B. Nelson, Lonnie Armistead-Jehle, Patrick Bowles, Amy O. TI Utility of the Mild Brain Injury Atypical Symptoms Scale as a Screening Measure for Symptom Over-Reporting in Operation Enduring Freedom/Operation Iraqi Freedom Service Members with Post-Concussive Complaints SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY LA English DT Article DE Mild traumatic brain injury; Post-concussion syndrome; Posttraumatic stress disorder; Symptom over-reporting ID POSTTRAUMATIC-STRESS-DISORDER; MMPI-2 VALIDITY SCALES; COMBAT VETERANS; COMPENSATION-SEEKING; POSTCONCUSSIVE SYMPTOMS; PSYCHOMETRIC PROPERTIES; PTSD CHECKLIST; EXAGGERATION; PERFORMANCE; RBS AB Evaluation of post-deployment conditions such as post-concussive syndrome (PCS) and posttraumatic stress disorder (PTSD) frequently relies upon brief, self-report checklists which are face valid and highly susceptible to potential symptom validity issues such as symptom exaggeration. We investigated the psychometric prope1rties of a 5-item measure of symptom exaggeration (mild brain injury atypical symptoms [mBIAS] scale) embedded in commonly used PCS and PTSD screening instruments in a sample of 403 patients seen in a brain injury clinic at a large military medical center. Exploratory factor analysis, examining measures of posttraumatic stress, post-concussive symptoms, and symptom over-reporting revealed a 6-factor model with the mBIAS scale items representing a unique factor. Analysis of psychometric properties demonstrated that a score of 8 on the mBIAS was optimal for the detection of symptom over-reporting (sensitivity = 0.94, specificity = 0.92) and appears to be the most favorable cut score for interpretive use. The findings provide a strong initial support for the use of the mBIAS in post-deployment populations. C1 [Cooper, Douglas B.] Brooke Army Med Ctr, Traumat Brain Injury Serv, Dept Orthoped & Rehabil, MCHE DOR TBI, Ft Sam Houston, TX 78234 USA. [Nelson, Lonnie] Def & Vet Brain Injury Ctr, Washington, DC USA. RP Cooper, DB (reprint author), Brooke Army Med Ctr, Traumat Brain Injury Serv, Dept Orthoped & Rehabil, MCHE DOR TBI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM douglas.b.cooper@us.army.mil RI Schueter, nicos/A-3625-2014 NR 38 TC 24 Z9 24 U1 0 U2 4 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0887-6177 J9 ARCH CLIN NEUROPSYCH JI Arch. Clin. Neuropsychol. PD DEC PY 2011 VL 26 IS 8 BP 718 EP 727 DI 10.1093/arclin/acr070 PG 10 WC Psychology, Clinical; Psychology SC Psychology GA 849UX UT WOS:000297151900003 PM 21873326 ER PT J AU Iverson, GL Hakulinen, U Waljas, M Dastidar, P Lange, RT Soimakallio, S Ohman, J AF Iverson, Grant L. Hakulinen, Ullamari Waljas, Minna Dastidar, Prasun Lange, Rael T. Soimakallio, Seppo Ohman, Juha TI To exclude or not to exclude: White matter hyperintensities in diffusion tensor imaging research SO BRAIN INJURY LA English DT Article DE Diffusion tensor imaging; methodology; traumatic brain injury ID TRAUMATIC BRAIN-INJURY; AXONAL INJURY; CORPUS-CALLOSUM; MILD; PREVALENCE; CHILDREN; ABNORMALITIES; POPULATION; DISORDER; MODERATE AB Objective: A practical methodological issue for diffusion tensor imaging (DTI) researchers is determining what to do about incidental findings, such as white matter hyperintensities (WMHI). The purpose of this study was to compare healthy control subjects with or without WMHIs on whole brain DTI. Method: Participants were 30 subjects (age=37.7, SD=11.3, Range=18-60; 70% female) who had no known developmental, general medical, neurological or psychiatric condition that could have had an adverse affect on brain morphology. Results: MRI (3 Tesla) revealed, at minimum, a WMHI in eight subjects (26.7%). Fractional anisotropy (FA) was calculated for 19 regions of interest (ROI). Frequency distributions of FA scores for the 19 ROIs were calculated. The 10th percentile for each ROI was selected as a cut-off score. Having four or more low FA scores occurred in 16.7%. More subjects with incidental findings met criterion for low FA scores (37.5%), compared to 9.1% of subjects with no findings. When subjects with minor WMHIs were retained and only those with multiple incidental findings were excluded, 8.3% of the retained subjects met criterion for low FA scores compared to 50.0% of the excluded subjects. Conclusions: The decision to include or exclude subjects who have incidental findings can influence the results of a study. C1 [Iverson, Grant L.] Univ British Columbia, Dept Psychiat, Vancouver, BC V6T 2A1, Canada. [Iverson, Grant L.] British Columbia Mental Hlth & Addict Serv, Vancouver, BC, Canada. [Hakulinen, Ullamari; Dastidar, Prasun; Soimakallio, Seppo] Pirkanmaa Hosp Dist, Med Imaging Ctr, Tampere, Finland. [Waljas, Minna; Ohman, Juha] Tampere Univ Hosp, Tampere, Finland. [Dastidar, Prasun; Soimakallio, Seppo; Ohman, Juha] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland. [Lange, Rael T.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Iverson, GL (reprint author), Univ British Columbia, Dept Psychiat, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. EM giverson@interchange.ubc.ca OI Ohman, Juha/0000-0002-6592-1367 FU Pirkanmaa Hospital District, Tampere University Hospital FX This study was supported by Competitive Research Funding of the Pirkanmaa Hospital District, Tampere University Hospital. Grant Iverson, PhD has been reimbursed by the government, professional scientific bodies and commercial organizations for discussing or presenting research relating to MTBI and sport-related concussion at meetings, scientific conferences and symposiums. He is a co-investigator, collaborator or consultant on grants relating to TBI funded by several organizations. Dr Lange notes that the views expressed in this article are those of the authors and do not reflect the official policy of the Department of Defense or US Government. NR 48 TC 16 Z9 16 U1 0 U2 3 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0269-9052 J9 BRAIN INJURY JI Brain Inj. PD DEC PY 2011 VL 25 IS 13-14 BP 1325 EP 1332 DI 10.3109/02699052.2011.608409 PG 8 WC Neurosciences; Rehabilitation SC Neurosciences & Neurology; Rehabilitation GA 847MI UT WOS:000296976600008 PM 22077537 ER PT J AU Aiello-Lammens, ME Chu-Agor, ML Convertino, M Fischer, RA Linkov, I Akcakaya, HR AF Aiello-Lammens, Matthew E. Chu-Agor, Ma Librada Convertino, Matteo Fischer, Richard A. Linkov, Igor Akcakaya, H. Resit TI The impact of sea-level rise on Snowy Plovers in Florida: integrating geomorphological, habitat, and metapopulation models SO GLOBAL CHANGE BIOLOGY LA English DT Article DE Charadrius alexandrinus; climate change; coastal land-cover; demographic modeling; MaxEnt; population viability analysis; RAMAS; SLAMM; species distribution modeling ID CLIMATE-CHANGE; POPULATION-MODELS; NATAL DISPERSAL; COASTAL-PLAIN; DISTRIBUTIONS; CONSERVATION; UNCERTAINTY; SHOREBIRDS; MAGNITUDE; VIABILITY AB Sea-level rise (SLR) is a projected consequence of global climate change that will result in complex changes in coastal ecosystems. These changes will cause transitions among coastal habitat types, which will be compounded by human-made barriers to the gradual inland migration of these habitat types. The effect of these changes on the future viability of coastal species will depend on the habitat requirements and population dynamics of these species. Thus, realistic assessments of the impact of SLR require linking geomorphological models with habitat and population models. In this study, we implemented a framework that allows this linkage, and demonstrated its feasibility to assess the effect of SLR on the viability of the Snowy Plover population in Florida. The results indicate that SLR will cause a decline in suitable habitat and carrying capacity for this species, and an increase in the risk of its extinction and decline. The model projected that the population size will decline faster than the area of habitat or carrying capacity, demonstrating the necessity of incorporating population dynamics in assessing the impacts of SLR on coastal species. The results were most sensitive to uncertainties in survival rate and fecundity, and suggested that future studies on this species should focus on the average and variability of these demographic rates and their dependence on population density. The effect of SLR on this species' viability was qualitatively similar with most alternative models that used the extreme values of each uncertain parameter, indicating that the results are robust to uncertainties in the model. C1 [Aiello-Lammens, Matthew E.; Akcakaya, H. Resit] SUNY Stony Brook, Dept Ecol & Evolut, New York, NY 11794 USA. [Chu-Agor, Ma Librada; Convertino, Matteo] Univ Florida, Dept Agr & Biol Engn IFAS, Gainesville, FL 32611 USA. [Fischer, Richard A.; Linkov, Igor] USA, ERDC, Vicksburg, MS 39180 USA. [Convertino, Matteo; Linkov, Igor] USA, ERDC, Risk Modeling & Decis Sci Grp, Concord, MA 01366 USA. RP Akcakaya, HR (reprint author), SUNY Stony Brook, Dept Ecol & Evolut, New York, NY 11794 USA. EM akcakaya@life.bio.sunysb.edu RI Akcakaya, H. Resit/A-7830-2008; OI Akcakaya, H. Resit/0000-0002-8679-5929; Chu, Ma Librada/0000-0003-3732-7165 FU US DOD SERDP [SI-1699] FX The authors acknowledge the intense work of the Florida Fish and Wildlife Conservation Commission and the Florida Shorebird Alliance (employees, researchers, volunteers, and land owners) for collecting the Snowy Plover data and making them available to the public. Chris Burney and Patricia Kelly (FWC) are acknowledged in particular. Gary Page gave permission to use the demographic data collected from Monterey Bay in our parameter estimates. The authors acknowledge the funding from the US DOD SERDP Program (Projects SI-1699). Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the US Army, or other sponsor organizations. NR 63 TC 30 Z9 32 U1 6 U2 74 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1354-1013 J9 GLOBAL CHANGE BIOL JI Glob. Change Biol. PD DEC PY 2011 VL 17 IS 12 BP 3644 EP 3654 DI 10.1111/j.1365-2486.2011.02497.x PG 11 WC Biodiversity Conservation; Ecology; Environmental Sciences SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 843XN UT WOS:000296710600011 ER PT J AU Kosinski, JA Palmer, WD Steer, MB AF Kosinski, John A. Palmer, W. Devereux Steer, Michael B. TI Unified Understanding of RF Remote Probing SO IEEE SENSORS JOURNAL LA English DT Article DE Harmonic radar; nonlinear radar; nonlinear radar equation; radar; radar cross section; radar detection; radar equation; remote sensing; radio frequency (RF) signals; radio frequency identification (RFID) ID MULTISLICE BEHAVIORAL-MODEL; HARMONIC RADAR; SPECTRAL REGROWTH; INTERMODULATION; AMPLIFIERS; SYSTEMS; DISTORTION; TRANSFORMATION; SCATTERERS; COMPONENTS AB Recent research has examined several novel radio frequency (RF) remote probing techniques. These new results are joined with the prior art leading to a unified understanding of RF remote probing that articulates the fundamental principles involved and allows extension to the analysis of additional "new" RF probing techniques. Two significant aspects in RF probing are emphasized: 1) information, coding, and signal theory considerations are identified as these establish bounds on probe performance against a specific information task and 2) building upon the well-known radar equation, the object cross section is generalized to be an interaction term describing a much broader range of interactions than simply reflection. These results are significant in enabling the rapid analysis and evaluation of "new" RF sensing techniques proposed to accomplish a variety of functions in the detection and identification of both natural and manmade objects. C1 [Kosinski, John A.] USA, Commun Elect Res Dev & Engn Ctr, Ft Monmouth, NJ 07703 USA. [Palmer, W. Devereux] USA, Div Elect, Engn Sci Directorate, Res Off, Res Triangle Pk, NC 27709 USA. [Steer, Michael B.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. RP Kosinski, JA (reprint author), Monmouth Univ, Dept Chem Med Technol & Phys, W Long Branch, NJ 07764 USA. EM jkosinsk@monmouth.edu; william.d.palmer44.civ@mail.mil; mbs@ncsu.edu RI Palmer, William/E-2296-2012 FU U.S. Army Research Laboratory/U.S. Army Research Office [W911NF-05-1-0337] FX Manuscript received July 19, 2011; revised August 27, 2011; accepted August 27, 2011. Date of publication September 06, 2011; date of current version October 28, 2011. This work was supported in part by the U.S. Army Research Laboratory/U.S. Army Research Office under Agreement W911NF-05-1-0337 "Standoff Inverse Analysis and Manipulation of Electronic Systems (SIAMES)" as part of an FY05 Multidisciplinary University Research Initiative (MURI). The associate editor coordinating the review of this paper and approving it for publication was Prof. Krikor Ozanyan. NR 56 TC 17 Z9 17 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X EI 1558-1748 J9 IEEE SENS J JI IEEE Sens. J. PD DEC PY 2011 VL 11 IS 12 BP 3055 EP 3063 DI 10.1109/JSEN.2011.2167228 PG 9 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 840RW UT WOS:000296459700002 ER PT J AU Jepsen, KJ Centi, A Duarte, GF Galloway, K Goldman, H Hampson, N Lappe, JM Cullen, DM Greeves, J Izard, R Nindl, BC Kraemer, WJ Negus, CH Evans, RK AF Jepsen, Karl J. Centi, Amanda Duarte, G. Felipe Galloway, Kathleen Goldman, Haviva Hampson, Naomi Lappe, Joan M. Cullen, Diane M. Greeves, Julie Izard, Rachel Nindl, Bradley C. Kraemer, William J. Negus, Charles H. Evans, Rachel K. TI Biological Constraints That Limit Compensation of a Common Skeletal Trait Variant Lead to Inequivalence of Tibial Function Among Healthy Young Adults SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Article DE FUNCTIONAL INEQUIVALENCE; ROBUSTNESS; TIBIA; STRENGTH; COMPLEX SYSTEMS ID COLLAGEN FIBER ORIENTATION; HUMAN MIDSHAFT FEMUR; CORTICAL BONE; MECHANICAL-PROPERTIES; STRESS-FRACTURES; BODY-SIZE; PHENOTYPIC INTEGRATION; GENDER-DIFFERENCES; PHYSICAL-ACTIVITY; STRENGTH INDEXES AB Having a better understanding of how complex systems like bone compensate for the natural variation in bone width to establish mechanical function will benefit efforts to identify traits contributing to fracture risk. Using a collection of pQCT images of the tibial diaphysis from 696 young adult women and men, we tested the hypothesis that bone cells cannot surmount the nonlinear relationship between bone width and whole bone stiffness to establish functional equivalence across a healthy population. Intrinsic cellular constraints limited the degree of compensation, leading to functional inequivalence relative to robustness, with slender tibias being as much as two to three times less stiff relative to body size compared with robust tibias. Using Path Analysis, we identified a network of compensatory trait interactions that explained 79% of the variation in whole-bone bending stiffness. Although slender tibias had significantly less cortical area relative to body size compared with robust tibias, it was the limited range in tissue modulus that was largely responsible for the functional inequivalence. Bone cells coordinately modulated mineralization as well as the cortical porosity associated with internal bone multicellular units (BMU)-based remodeling to adjust tissue modulus to compensate for robustness. Although anecdotal evidence suggests that functional inequivalence is tolerated under normal loading conditions, our concern is that the functional deficit of slender tibias may contribute to fracture susceptibility under extreme loading conditions, such as intense exercise during military training or falls in the elderly. Thus, we show the natural variation in bone robustness was associated with predictable functional deficits that were attributable to cellular constraints limiting the amount of compensation permissible in human long bone. Whether these cellular constraints can be circumvented prophylactically to better equilibrate function among individuals remains to be determined. (C) 2011 American Society for Bone and Mineral Research. C1 [Jepsen, Karl J.; Duarte, G. Felipe] Mt Sinai Sch Med, Dept Orthopaed, New York, NY 10029 USA. [Centi, Amanda; Nindl, Bradley C.; Evans, Rachel K.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Galloway, Kathleen] Belmont Univ, Sch Phys Therapy, Nashville, TN USA. [Goldman, Haviva; Hampson, Naomi] Drexel Univ, Coll Med, Dept Neurobiol & Anat, Philadelphia, PA 19104 USA. [Goldman, Haviva; Hampson, Naomi] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Lappe, Joan M.; Cullen, Diane M.] Creighton Univ, Div Endocrinol, Omaha, NE 68178 USA. [Lappe, Joan M.; Cullen, Diane M.] Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA. [Greeves, Julie; Izard, Rachel] HQ Army Recruiting & Training Div, Dept Occupat Med, Upavon, Wilts, England. [Kraemer, William J.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA. [Kraemer, William J.] Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA. [Negus, Charles H.] L3 Appl Technol Grp Jaycor, San Diego, CA USA. RP Jepsen, KJ (reprint author), Mt Sinai Sch Med, Dept Orthopaed, Box 1188,1 Gustave Levy Pl, New York, NY 10029 USA. EM karl.jepsen1@gmail.com FU US Department of Defense [W81XWH-09-2-0113, W81XWH-07-C-0097] FX We are grateful to D Catrambone, P Nasser, N Gendron, R Ghillani, B Spiering, H Isome, M Lester, N Andarawis-Puri, M Faillace, and CJ Terranova for materials and discussion. This work was supported by grants from the US Department of Defense (W81XWH-09-2-0113, W81XWH-07-C-0097). The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the Department of Defense. NR 58 TC 27 Z9 27 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD DEC PY 2011 VL 26 IS 12 BP 2872 EP 2885 DI 10.1002/jbmr.497 PG 14 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 849QB UT WOS:000297139100011 PM 21898595 ER PT J AU Alving, CR Rao, M Peachman, KK Asher, L Rao, VB AF Alving, Carl R. Rao, Mangala Peachman, Kristina K. Asher, Ludmila Rao, Venigalla B. TI Liposomes containing glucosyl ceramide specifically bind T4 bacteriophage: a self-assembling nanocarrier formulation SO JOURNAL OF LIPOSOME RESEARCH LA English DT Article DE Adjuvant; nanotechnology; vaccines ID IMMUNODEFICIENCY-VIRUS TYPE-1; VACCINE ADJUVANTS; LIPID-A; BACTERIOPHAGE-T4; LIPOPOLYSACCHARIDE; PROTEIN; STRATEGY; ANTIGENS; DISPLAY; REGION AB A unique formulation is described comprising liposomes containing glucosyl ceramide (GluCer) in the lipid bilayer to which bacteriophage T4 was attached. Binding of the phage T4 did not occur to glycolipids, such as galactosyl ceramide, containing an aldose in which the C-2 or C-4 conformations were not identical to glucose. These results strongly support previous proposals that glucose is a major receptor moiety for T4 binding to Escherichia coli. By using the binding of T4 to liposomal GluCer, we further describe a formulation that can be used as a self-assembling combined antigen and adjuvant carrier. A peptide antigen derived from C-trimer (Ct) of HIV-1 gp41 was fused to the highly antigenic outer capsid protein (Hoc), a nonessential protein of T4 that spontaneously binds to the T4 capsid. This resulted in display of the Ct-Hoc construct on the T4 capsid, and specific binding of a human monoclonal antibody that recognizes a peptide sequence of Ct was demonstrated. Liposomes containing monophosphoryl lipid A (MPLA) have been demonstrated to have potent adjuvant activities for experimental vaccines both in humans and animals, and because of this, mice were immunized with the Ct-Hoc-T4 construct that was bound to liposomes containing both GluCer and MPLA, resulting in the induction of high titers of Ct-specific antibodies. We conclude that liposomes containing both GluCer and MPLA can spontaneously bind to a construct of T4 that displays antigens that spontaneously binds to the capsid of T4 bacteriophage. This formulation could be utilized as an easily manufactured self-assembling antigen and adjuvant carrier. C1 [Alving, Carl R.; Rao, Mangala; Peachman, Kristina K.; Asher, Ludmila] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Rockville, MD 20850 USA. [Peachman, Kristina K.; Asher, Ludmila; Rao, Venigalla B.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Rockville, MD USA. Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA. RP Alving, CR (reprint author), Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Dept Adjuvant & Antigen Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM calving@hivresearch.org FU Henry M. Jackson Foundation for the Advancement of Military Medicine [DAMD17-93-V-3004]; U.S. Army Medical Research and Material Command FX This work was supported through Cooperative Agreement no. DAMD17-93-V-3004 between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Army Medical Research and Material Command, working together with the Division of AIDS, National Institute for Allergy and Infectious Diseases, National Institutes of Health (Bethesda, Maryland, USA). NR 24 TC 0 Z9 0 U1 1 U2 5 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0898-2104 J9 J LIPOSOME RES JI J. Liposome Res. PD DEC PY 2011 VL 21 IS 4 BP 279 EP 285 DI 10.3109/08982104.2011.559646 PG 7 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 848OF UT WOS:000297060200003 PM 21401373 ER PT J AU Kadriu, B Gocel, J Larson, J Guidotti, A Davis, JM Nambiar, MP Auta, J AF Kadriu, Bashkim Gocel, James Larson, John Guidotti, Alessandro Davis, John M. Nambiar, Madhusoodana P. Auta, James TI Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage SO NEUROPHARMACOLOGY LA English DT Article DE Imidazenil; Diazepam; Benzodiazepine; Organophosphates; Neuropathology; Seizure; Tolerance ID GAMMA-AMINOBUTYRIC-ACID; GULF-WAR SYNDROME; DIISOPROPYL FLUOROPHOSPHATE TOXICITY; ORGANOPHOSPHORUS NERVE AGENTS; POSITIVE ALLOSTERIC MODULATOR; RECEPTOR SUBUNIT EXPRESSION; GABA(A) RECEPTORS; STATUS EPILEPTICUS; DOWN-REGULATION; DIAZEPAM AB The clinical use of diazepam or midazolam to control organophosphate (OP) nerve agent-induced seizure activity is limited by their unwanted effects including sedation, amnesia, withdrawal, and anticonvulsant tolerance. Imidazenil is an imidazo-benzodiazepine derivative with high intrinsic efficacy and selectivity for alpha 2-, alpha 3-, and alpha 5- but low intrinsic efficacy for alpha 1-containing GABA(A) receptors. We have previously shown that imidazenil is more efficacious than diazepam at protecting rats and mice from diisopropyl fluorophosphate (DFP)-induced seizures and neuronal damage without producing sedation. In the present study, we compared the tolerance liability of imidazenil and diazepam to attenuate the seizure activity and neurotoxic effects of DFP. Rats received protracted (14 days) oral treatment with increasing doses of imidazenil (1-4 mg/kg), diazepam (5-20 mg/kg), or vehicle. Eighteen hours after the last dose of the protracted treatment schedule, rats were tested for anticonvulsant tolerance after a 30 min pretreatment with a single test dose of imidazenil (0.5 mg/kg) or diazepam (5 mg/kg) prior to a DFP challenge (1.5 mg/kg). The anticonvulsant (modified Racine score scale) and neuroprotective (fluoro-jade B staining) effects of diazepam were significantly reduced in protracted diazepam-treated animals whereas the effects of imidazenil were not altered in protracted imidazenil-treated animals. The present findings indicate that protracted imidazenil treatment does not produce tolerance to its protective action against the neurotoxic effects of OP exposure. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Kadriu, Bashkim; Gocel, James; Larson, John; Guidotti, Alessandro; Davis, John M.; Auta, James] Univ Illinois, Dept Psychiat, Coll Med, Inst Psychiat, Chicago, IL 60612 USA. [Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Closed Head Injury Branch, Silver Spring, MD 20910 USA. RP Auta, J (reprint author), Univ Illinois, Dept Psychiat, Coll Med, Inst Psychiat, 1601 W Taylor St,Room 283, Chicago, IL 60612 USA. EM jauta@psych.uic.edu FU SBIR [W81XWH-05-C-0125] FX This work was supported by SBIR grant: [W81XWH-05-C-0125] to Neupharm Inc. (513 Central Avenue, Chicago IL) subcontracted to the Board of Trustees of the University of Illinois (Department of Psychiatry). NR 68 TC 2 Z9 2 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0028-3908 J9 NEUROPHARMACOLOGY JI Neuropharmacology PD DEC PY 2011 VL 61 IS 8 BP 1463 EP 1469 DI 10.1016/j.neuropharm.2011.08.043 PG 7 WC Neurosciences; Pharmacology & Pharmacy SC Neurosciences & Neurology; Pharmacology & Pharmacy GA 848VB UT WOS:000297082100034 PM 21903116 ER PT J AU Proctor, SP Heaton, KJ Smith, KW Rodrigues, ER Widing, DE Herrick, R Vasterling, JJ McClean, MD AF Proctor, Susan P. Heaton, Kristin J. Smith, Kristen W. Rodrigues, Ema R. Widing, Drew E. Herrick, Robert Vasterling, Jennifer J. McClean, Michael D. TI The Occupational JP8 Exposure Neuroepidemiology Study (OJENES): Repeated workday exposure and central nervous system functioning among US Air Force personnel SO NEUROTOXICOLOGY LA English DT Article DE JP8; Jet fuel; Central nervous system; Exposure assessment; Military ID VOLATILE ORGANIC-COMPOUNDS; CLINICAL BALANCE TESTS; TRUNK SWAY MEASURES; S-TRANSFERASE M1; JET FUEL JP-8; POSTURAL STABILITY; MASS-SPECTROMETRY; DERMAL EXPOSURE; BENZENE; WORKERS AB One of the most prevalent workplace chemical exposures historically and currently confronting the global military and civilian workforce is jet propellant (JP) fuel (e.g., JP4, JP5, JP8, jet A1), a complex mixture of numerous hydrocarbon compounds and additives. To date, numerous protective and preventive strategies (e.g., federal exposure limits, workplace procedure protocols, protective gear such as goggles, respirator use, gloves, and coveralls) have been put in place to minimize acutely toxic exposure levels. However, questions remain regarding the effect of repeated exposures at lower (than regulated) levels of JP fuel. The Occupational JP8 Exposure Neuroepidemiology Study (OJENES) was designed to examine the relationships between occupational JP8 exposure over multiple, repeated workdays and specific aspects of central nervous system (CNS) functioning among Air Force (AF) personnel. In this report, we present the OJENES methodology, descriptive findings related to participant characteristics, JP8 exposure levels observed over a work week among higher and lower exposure groups, and neuropsychological task performances at the first study assessment. Results indicated minimal differences between participants in the high and lower exposure groups in terms of descriptive characteristics, other than daily JP8 exposure levels (p < 0.001). In addition, neuropsychological task performances for most task measures were not found to be significantly different from reported reference ranges. These findings demonstrated that confounding and misclassification of exposure and outcome status are not major concerns for the study. Therefore, future OJENES analyses targeting the more focused research questions regarding associations between JP8 exposure and CNS functioning are likely to provide valid conclusions, as they will be less influenced by these research biases. (C) 2011 Elsevier Inc. All rights reserved. C1 [Proctor, Susan P.; Heaton, Kristin J.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Proctor, Susan P.] VA Boston Healthcare Syst, Res Serv, Boston, MA 02130 USA. [Proctor, Susan P.; Heaton, Kristin J.; Smith, Kristen W.; Rodrigues, Ema R.; McClean, Michael D.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA. [Widing, Drew E.] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA. [Herrick, Robert] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Vasterling, Jennifer J.] VA Boston Healthcare Syst, Psychol Serv, Boston, MA 02130 USA. [Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. RP Proctor, SP (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Kansas St,Bldg 42, Natick, MA 01760 USA. EM susan.proctor@us.army.mil RI Heaton, Kristin/E-3660-2013; McClean, Michael/J-2934-2015; OI McClean, Michael/0000-0002-3902-8823 FU U.S. Air Force; US Army Medical Research [W81XWH-06-1-0105] FX We thank the U.S. Air Force personnel for their support and generous participation in the project. We are grateful to LTC Theresa Brininger, along with additional Boston area study team personnel (N. Longcore, E. Kryskow, K. Merchant-Borna, H. MacDonald, and A. Graefe) and other personnel from local universities for their assistance in Study 2 data collection process at the respective US Air Force base locations. We acknowledge and appreciate the personnel at the Organic Chemistry Analytical Laboratory at the Harvard School of Public Health (HSPH), Centers for Disease Control and Prevention (CDC, Combustion Products and Persistent Pollutants Biomonitoring Laboratory, VOC and Perchlorate Laboratory, and Tobacco Exposure Biomarkers Laboratory), and Brown University (Center for Environmental Health and Technology) for the timely analyses of collected environmental and personal samples. We appreciate the assistance of Ms. Alexis Maule in helping to prepare this manuscript for submission. This work was supported by the US Army Medical Research and Materiel Command/Neurotoxin Exposure Treatment Program (NETRP) through a grant award (W81XWH-06-1-0105: PI: S. P. Proctor) to the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. NR 70 TC 4 Z9 4 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2011 VL 32 IS 6 BP 799 EP 808 DI 10.1016/j.neuro.2011.06.010 PG 10 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 847VK UT WOS:000297000400014 PM 21824494 ER PT J AU Langston, JL Myers, TM AF Langston, Jeffrey L. Myers, Todd M. TI Diet composition modifies the toxicity of repeated soman exposure in rats SO NEUROTOXICOLOGY LA English DT Article DE Organophosphorus nerve agent; Soman; Diet composition; Survival; Body weight; Active avoidance behavior; Rat ID PARATHION-INDUCED NEUROTOXICITY; INDUCED MEMORY IMPAIRMENT; ESTERASE-1 ES-1 ACTIVITY; NERVE AGENT TOXICITY; HIGH-FAT DIETS; KETOGENIC DIET; BLOOD-GLUCOSE; CHOLINE SUPPLEMENTATION; KETONE-BODIES; ACETYLCHOLINE-RELEASE AB It was previously demonstrated that diet potently modulates the toxic effects of an acute lethal dose of the nerve agent soman. The current investigation was undertaken to examine the influence of diet on the cumulative toxicity of repeated soman administration. Rats were fed one of four distinct diets (standard, choline-enriched, glucose-enriched, or ketogenic) for four weeks prior to and throughout a repeated soman dosing and recovery regimen. Each diet group included animals exposed to an equivalent volume of saline that served as negative controls. In exposure Week 1, animals received three consecutive daily doses of 0.4 LD(50) soman. In exposure Week 2, animals received four consecutive daily doses of 0.5 LD(50) soman. In exposure Week 3, animals received five consecutive daily doses of 0.5 LD(50) soman. Week 4 constituted a post-exposure recovery evaluation. Throughout the experiment, behavioral function was assessed by a discriminated avoidance test that required intact sensory and motor function. Survival and body weight changes were recorded daily. Differences in toxicity as a function of diet composition became apparent during the first week. Specifically, rats fed the glucose-enriched diet showed pronounced intoxication during Week 1, resulting in imperfect survival, weight loss, and deteriorated avoidance performance relative to all other groups. All rats fed the glucose-enriched diet died by the end of exposure Week 2. In contrast, only 10% of animals fed the standard diet died by the end of Week 2. Also in Week 2, weight loss and disrupted avoidance performance were apparent for all groups except for those fed the ketogenic diet. This differential effect of diet composition became even more striking in Week 3 when survival in the standard and choline diet groups approximated 50%, whereas survival equaled 90% in the ketogenic diet group. Avoidance performance and weight loss measures corroborated the differential toxicity observed across diet groups. Upon cessation of soman exposure during the final week, recovery of weight and avoidance performance in survivors was comparable across diet groups. These results systematically replicate previous findings demonstrating that diet composition exacerbates or attenuates toxicity in rodents exposed acutely to organophosphorus compounds. Published by Elsevier Inc. C1 [Langston, Jeffrey L.; Myers, Todd M.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Myers, TM (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Todd.Myers2@us.army.mil FU Defense Threat Reduction Agency, Joint Science and Technology Office, Medical ST Division; U.S. Army Medical Research Institute of Chemical Defense FX This research was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office, Medical S&T Division.; This research was supported in part by an appointment to the Postgraduate Research Participation Program (JLL) at the U.S. Army Medical Research Institute of Chemical Defense administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 64 TC 2 Z9 2 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2011 VL 32 IS 6 BP 907 EP 915 DI 10.1016/j.neuro.2011.05.006 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 847VK UT WOS:000297000400027 PM 21641933 ER PT J AU White, RF Palumbo, CL Yurgelun-Todd, DA Heaton, KJ Weihe, P Debes, F Grandjean, P AF White, Roberta F. Palumbo, Carole L. Yurgelun-Todd, Deborah A. Heaton, Kristin J. Weihe, Pal Debes, Frodi Grandjean, Philippe TI Functional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicity SO NEUROTOXICOLOGY LA English DT Article DE Developmental neurotoxicity; Environmental exposure; Functional magnetic resonance imaging; Methylmercury; Neurotoxicity syndromes; Polychlorinated biphenyls; Prenatal exposure delayed effects ID 7-YEAR-OLD CHILDREN; EXPOSURE; BRAIN; IMPACT AB Prenatal and early childhood exposure to methylmercury (MeHg) or polychlorinated biphenyls (PCBs) are associated with deficits in cognitive, sensory, motor and other functions measured by neurobehavioral tests. The main objective of this pilot study was to determine whether functional magnetic resonance imaging (fMRI) is effective for visualization of brain function alterations related to neurobehavior in subjects with high prenatal exposure to the two neurotoxicants, MeHg and PCBs. Twelve adolescents (all boys) from a Faroese birth cohort assembled in 1986-1987 were recruited based on their prenatal exposures to MeHg and PCB. All underwent fMRI scanning during behavioral tasks at age 15 years. Subjects with high mixed exposure to MeHg and PCBs were compared to those with low mixed exposure on fMRI photic stimulation and a motor task. Boys with low mixed exposures showed patterns of fMRI activation during visual and motor tasks that are typical of normal control subjects. However, those with high exposures showed activation in more areas of the brain and different and wider patterns of activation than the low mixed exposure group. The brain activation patterns observed in association with increased exposures to MeHg and PCBs are meaningful in regard to the known neurotoxicity of these substances. This methodology therefore has potential utility in visualizing structural neural system determinants of exposure-induced neurobehavioral dysfunction. (C) 2011 Elsevier Inc. All rights reserved. C1 [White, Roberta F.; Heaton, Kristin J.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA. [White, Roberta F.; Palumbo, Carole L.] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. [Yurgelun-Todd, Deborah A.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Heaton, Kristin J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Grandjean, Philippe] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA. [Grandjean, Philippe] Univ So Denmark, Dept Environm Med, Odense, Denmark. [Yurgelun-Todd, Deborah A.] Univ Utah, Inst Brain, Salt Lake City, UT USA. RP White, RF (reprint author), Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA. EM rwhite@bu.edu RI Heaton, Kristin/E-3660-2013; OI White, Roberta/0000-0002-2001-6646; Grandjean, Philippe/0000-0003-4046-9658 FU Danish Medical Research Council; National Institute of Environmental Health Sciences [ES09797] FX This work was funded by a grant from the Danish Medical Research Council and by the National Institute of Environmental Health Sciences (ES09797). The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the NIEHS, NIH or any other funding agency. The authors wish to thank the 12 Faroese adolescents who participated in this project, their parents, and the Faroese chaperones (Sara Weihe and Johan Peter Weihe). NR 30 TC 8 Z9 8 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD DEC PY 2011 VL 32 IS 6 BP 975 EP 980 DI 10.1016/j.neuro.2011.04.001 PG 6 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 847VK UT WOS:000297000400035 PM 21545807 ER PT J AU Chambers, JP Yu, JJ Jupelli, M Weintraub, ST Lopez-Ribot, JL Valdes, JJ Arulanandam, BP AF Chambers, James P. Yu, Jieh-Juen Jupelli, Madhulika Weintraub, Susan T. Lopez-Ribot, Jose L. Valdes, James J. Arulanandam, Bernard P. TI Alpha-1 antitrypsin is markedly decreased following pulmonary F. tularensis challenge SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY LA English DT Article DE antiprotease; neutrophil; elastase; plasma; lung lavage; Francisella AB Neutrophils form the first line of defense during infection and are indispensable in this function. The neutrophil elastase is a key effector molecule of the innate immune system with potent antimicrobial activity against Gram-negative bacteria, spirochaetes, and fungi. However, the release of neutrophil elastase during bacterial infection must be checked otherwise its release in the extracellular milieu will result in damage to surrounding tissues. Alpha-1 antitrypsin is a small glycoprotein clade A serpine serine protease inhibitor and has been shown to increase in humans following bacterial and viral infection. Francisella tularensis is a Gram-negative facultative intracellular bacterium and the causative agent of tularemia. Type A strains are the most virulent with an infectious dose as low as 10 colony forming units and a mortality rate of 30-60% among untreated cases of pneumonic tularemia. We report here significant reduction of this major inhibitor of the neutrophil elastase in plasma of F tularensis LVS and F tularensis (type A) SCHU S4 infected animals following pulmonary challenge. Associated with an imbalance of protease antiprotease function at the alveolar level in lungs of infected animals, increased elastase activity was observed in lung lavage fluids accompanied by decrease lung function, i.e., loss of lung elastance with concomitant increase of pulmonary hysteresivity. Consistent with a competent acute phase response following F tularensis LVS and F tularensis (type A) SCHU S4 pulmonary challenge and proposed up-regulation of plasma haptoglobin during the course of the acute phase reaction, haptoglobin was observed significantly increased. These data suggest that unchecked neutrophil serine protease activity may arise from F tularensis targeted reduction of plasma alpha(1)-antitrysin promoting lung tissue damage facilitating increased dissemination of this bacterium in infected animals. C1 [Chambers, James P.; Yu, Jieh-Juen; Jupelli, Madhulika; Lopez-Ribot, Jose L.; Arulanandam, Bernard P.] Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, Dept Biol, San Antonio, TX 78249 USA. [Chambers, James P.; Yu, Jieh-Juen; Lopez-Ribot, Jose L.; Arulanandam, Bernard P.] Univ Texas San Antonio, Ctr Excellence Infect Genom, Dept Biol, San Antonio, TX 78249 USA. [Weintraub, Susan T.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Valdes, James J.] US Army, Engn Chem Biol Command, Aberdeen Proving Ground, MD USA. RP Chambers, JP (reprint author), Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, Dept Biol, Ctr Excellence Infect Genom, San Antonio, TX 78249 USA. EM james.chambers@utsa.edu RI Arulanandam, Bernard/O-9501-2014 FU Army Research Office of the Department of Defense [W911NF-11-1-0136, 14-3300-24]; National Institutes of Health [PO1 AI057986] FX This material is based upon the work supported by the Army Research Office of the Department of Defense under Contract No. W911NF-11-1-0136, SALSI Grant 14-3300-24, and National Institutes of Health, PO1 AI057986. Mass spectrometry analyses were conducted at the Institutional Mass Spectrometry Laboratory of the University of Texas Health Science Center at San Antonio. NR 37 TC 2 Z9 2 U1 0 U2 0 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 2235-2988 J9 FRONT CELL INFECT MI JI Front. Cell. Infect. Microbiol. PD DEC PY 2011 VL 1 AR UNSP 20 DI 10.3389/fcimb.2011.00020 PG 6 WC Immunology; Microbiology SC Immunology; Microbiology GA V29TG UT WOS:000208770100010 PM 22919586 ER PT J AU Stiles, BG Wigelsworth, DJ Popoff, MR Barth, H AF Stiles, Bradley G. Wigelsworth, Darran J. Popoff, Michel R. Barth, Holger TI Clostridial binary toxins: iota and C2 family portraits SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY LA English DT Review DE actin; Bacillus; Clostridium; protein toxins AB There are many pathogenic Clostridium species with diverse virulence factors that include protein toxins. Some of these bacteria, such as C. botulinum, C. difficile, C. perfringens, and C. spiroforme, cause enteric problems in animals as well as humans. These often fatal diseases can partly be attributed to binary protein toxins that follow a classic AB paradigm. Within a targeted cell, all clostridial binary toxins destroy filamentous actin via mono-ADP-ribosylation of globular actin by the A component. However, much less is known about B component binding to cell-surface receptors. These toxins share sequence homology amongst themselves and with those produced by another Gram-positive, spore-forming bacterium also commonly associated with soil and disease: Bacillus anthracis. This review focuses upon the iota and C2 families of clostridial binary toxins and includes: (1) basics of the bacterial source; (2) toxin biochemistry; (3) sophisticated cellular uptake machinery; and (4) host-cell responses following toxin-mediated disruption of the cytoskeleton. In summary, these protein toxins aid diverse enteric species within the genus Clostridium. C1 [Stiles, Bradley G.] Wilson Coll, Dept Biol, Chambersburg, PA 17201 USA. [Stiles, Bradley G.; Wigelsworth, Darran J.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD USA. [Popoff, Michel R.] Inst Pasteur, CNR Anaerobies, Paris, France. [Barth, Holger] Univ Ulm, Med Ctr, Inst Pharmacol & Toxicol, D-89081 Ulm, Germany. RP Stiles, BG (reprint author), Wilson Coll, Dept Biol, 1015 Philadelphia Ave, Chambersburg, PA 17201 USA. EM bstiles@wilson.edu; holger.barth@uni-ulm.de RI Popoff, Michel/O-7719-2016 OI Popoff, Michel/0000-0001-9305-8989 FU Deutsche Forschungsgemeinschaft (DFG); Faculty of Medicine, Ulm FX Bradley G. Stiles appreciates the computer support and overall constructive environment throughout Wilson College for communicating science. Work of the Holger Barth laboratory included in this review was funded by the Deutsche Forschungsgemeinschaft (DFG) and the Faculty of Medicine, Ulm. NR 175 TC 16 Z9 16 U1 1 U2 4 PU FRONTIERS RESEARCH FOUNDATION PI LAUSANNE PA PO BOX 110, LAUSANNE, 1015, SWITZERLAND SN 2235-2988 J9 FRONT CELL INFECT MI JI Front. Cell. Infect. Microbiol. PD DEC PY 2011 VL 1 AR UNSP 11 DI 10.3389/fcimb.2011.00011 PG 14 WC Immunology; Microbiology SC Immunology; Microbiology GA V29TG UT WOS:000208770100001 PM 22919577 ER PT J AU Farmer, TJ Darwish, A Huebschman, B Viveiros, E Zaghloul, ME AF Farmer, Thomas J. Darwish, Ali Huebschman, Benjamin Viveiros, Edward Zaghloul, Mona E. TI High power density SiGe millimeter-wave power amplifiers SO INTERNATIONAL JOURNAL OF MICROWAVE AND WIRELESS TECHNOLOGIES LA English DT Article DE Circuit design and applications; Microwave measurements; Power amplifiers and linearizers; Radar applications; Si-based devices and IC technologies AB This paper presents measured results for two-stage and three-stage high-voltage/high-power (HiVP) amplifiers implemented in a commercial 0.12 mu m silicon germanium (SiGe) heterojunction bipolar transistor (HBT) bipolar Complementary Metal Oxide Semiconductor (BiCMOS) process at millimeter wave. The HiVP configuration provides a new tool for millimeter-wave silicon designers to achieve large output voltage swings, high output power density, customizable bias, and a way to minimize, if not eliminate, matching circuitry at millimeter-wave frequencies. The two-stage amplifier has achieved a P-SAT = 5.41 dBm with a power added efficiency (PAE) of 8.06% at center frequency 30 GHz. The three-stage amplifier has achieved a P-SAT = 8.85 dBm with a PAE of 11.35% with a total chip area of 0.068 mm(2) at center frequency 30 GHz. Simulation, layout, fabrication, and measurement results are presented in this paper. C1 [Farmer, Thomas J.; Huebschman, Benjamin; Viveiros, Edward] USA, Res Lab, Adelphi, MD 20783 USA. [Darwish, Ali] Amer Univ Cairo, New Cairo 11835, Egypt. [Zaghloul, Mona E.] George Washington Univ, Dept Elect & Comp Engn, Washington, DC 20052 USA. RP Farmer, TJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM thomas.farmer2@us.army.mil FU George Washington University (GWU); Achievement Rewards for College Scientists (ARCS); US Army Research Laboratory FX This work was supported in part by The George Washington University (GWU), The Achievement Rewards for College Scientists (ARCS), and by an appointment to the US Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the US Army Research Laboratory. NR 10 TC 0 Z9 0 U1 1 U2 6 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 1759-0787 J9 INT J MICROW WIREL T JI Int. J. Microw. Wirel. Technol. PD DEC PY 2011 VL 3 IS 6 BP 615 EP 620 DI 10.1017/S1759078711000638 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA V27LB UT WOS:000208613600004 ER PT J AU Ford, WM Britzke, ER Dobony, CA Rodrigue, JL Johnson, JB AF Ford, W. Mark Britzke, Eric R. Dobony, Christopher A. Rodrigue, Jane L. Johnson, Joshua B. TI Patterns of Acoustical Activity of Bats Prior to and Following White-Nose Syndrome Occurrence SO JOURNAL OF FISH AND WILDLIFE MANAGEMENT LA English DT Article DE acoustical activity; bats; monitoring; Myotis; white-nose syndrome ID ECHOLOCATION CALLS; HABITAT PREFERENCE; TEMPORAL PATTERNS; FOREST LANDSCAPE; MYOTIS-LUCIFUGUS; SOUTH-CAROLINA; NORTH-AMERICA; COASTAL-PLAIN; UNITED-STATES; BROWN BATS AB White-nose Syndrome (WNS), a wildlife health concern that has decimated cave-hibernating bat populations in eastern North America since 2006, began affecting source-caves for summer bat populations at Fort Drum, a U. S. Army installation in New York in the winter of 2007-2008. As regional die-offs of bats became evident, and Fort Drum's known populations began showing declines, we examined whether WNS-induced change in abundance patterns and seasonal timing of bat activity could be quantified using acoustical surveys, 2003-2010, at structurally uncluttered riparian-water habitats (i.e., streams, ponds, and wet meadows). As predicted, we observed significant declines in overall summer activity between pre-WNS and post-WNS years for little brown bats Myotis lucifugus, northern bats M. septentrionalis, and Indiana bats M. sodalis. We did not observe any significant change in activity patterns between pre-WNS and post-WNS years for big brown bats Eptesicus fuscus, eastern red bats Lasiurus borealis, or the small number of tri-colored bats Perimyotis subflavus. Activity of silver-haired bats Lasionycteris noctivagans increased from pre-WNS to post-WNS years. Activity levels of hoary bats Lasiurus cinereus significantly declined between pre- and post-WNS years. As a nonhibernating, migratory species, hoary bat declines might be correlated with wind-energy development impacts occurring in the same time frame rather than WNS. Intraseason activity patterns also were affected by WNS, though the results were highly variable among species. Little brown bats showed an overall increase in activity from early to late summer pre-WNS, presumably due to detections of newly volant young added to the local population. However, the opposite occurred post-WNS, indicating that reproduction among surviving little brown bats may be declining. Our data suggest that acoustical monitoring during the summer season can provide insights into species' relative abundance on the landscape as affected by the occurrence of WNS. C1 [Ford, W. Mark] Virginia Polytech Inst & State Univ, US Geol Survey, Virginia Fish & Wildlife Cooperat Res Unit, Blacksburg, VA 24061 USA. [Britzke, Eric R.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Dobony, Christopher A.] USA, Installat Command, Ft Drum, NY 13602 USA. [Rodrigue, Jane L.] US Forest Serv, No Res Stn, Princeton, WV 24740 USA. [Johnson, Joshua B.] Univ Maryland, Ctr Environm Sci, Appalachian Lab, Frostburg, MD 21532 USA. RP Ford, WM (reprint author), Virginia Polytech Inst & State Univ, US Geol Survey, Virginia Fish & Wildlife Cooperat Res Unit, Blacksburg, VA 24061 USA. EM wmford@vt.edu FU Department of the Army, Fort Drum; U.S. Forest Service Northern Research Station; U.S. Army Engineer and Research Development Center FX We thank R. Rainbolt for assistance throughout this project. Comments from the Subject Editor and three anonymous reviewers greatly improved this manuscript. This work was funded by financial and in-kind contributions of the Department of the Army, Fort Drum, the U.S. Army Engineer and Research Development Center, and the U.S. Forest Service Northern Research Station. NR 54 TC 14 Z9 16 U1 4 U2 73 PU U S FISH & WILDLIFE SERVICE PI SHEPHERDSTOWN PA NATL CONSERVATION TRAINING CENTER, CONSERVATION LIBRARY, 698 CONSERVATION WAY, SHEPHERDSTOWN, WV 25443 USA SN 1944-687X J9 J FISH WILDL MANAG JI J. Fish Wildl. Manag. PD DEC PY 2011 VL 2 IS 2 BP 125 EP 134 DI 10.3996/042011-JFWM-027 PG 10 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 044NC UT WOS:000311625500002 ER PT J AU Niu, JJ Presser, V Karwacki, CJ Gogotsi, Y AF Niu, Jun Jie Presser, Volker Karwacki, Christopher J. Gogotsi, Yury TI Ultrasmall Gold Nanoparticles with the Size Controlled by the Pores of Carbide-Derived Carbon SO MATERIALS EXPRESS LA English DT Article DE Gold Nanoparticles; Carbide-Derived Carbon; Catalyst; CO Oxidation ID CATALYTIC-ACTIVITY; CO OXIDATION; MOLYBDENUM CARBIDE; FABRICATION; ADSORPTION; NUCLEATION; MICROSCOPY; CLUSTERS; MONOXIDE; DIOXIDE AB Gold nanoparticles (Au-NPs) with a narrow size distribution and average sizes ranging from a few Angstroms to several nanometers were selectively adsorbed on porous carbide-derived carbons (CDCs). CDC powders were synthesized by chlorinating several carbide precursors (TiC, Mo2C, B4C, and SiC) at different temperatures (800 degrees C for TiC-CDC, 1100 degrees C for B4C-CDC, 600 and 1200 degrees C for Mo2C-CDC, and 1000 degrees C for SiC-CDC). The size and distribution of the Au-NPs largely reflects the pore size and pore size distribution of the CDC. Catalytic activity of carbon-supported gold was a size-dependent parameter and the highest CO oxidation was identified for the smallest particles. Since the pore size of CDC can be varied from about sub-nanometer to several nanometers with a narrow distribution and the surface chemistry of CDC can be easily modified, the proposed method can be used for selective trapping of a variety of metal and nonmetal nanoparticles for catalytic and other applications. C1 [Niu, Jun Jie; Presser, Volker; Karwacki, Christopher J.; Gogotsi, Yury] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Niu, Jun Jie; Presser, Volker; Karwacki, Christopher J.; Gogotsi, Yury] Drexel Univ, AJ Drexel Nanotechnol Inst, Philadelphia, PA 19104 USA. [Karwacki, Christopher J.] USA, Aberdeen Proving Ground, MD 21010 USA. RP Gogotsi, Y (reprint author), Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. EM gogotsi@drexel.edu RI Presser, Volker/F-1975-2010 OI Presser, Volker/0000-0003-2181-0590 FU US Army Research Office; Alexander von Humboldt Foundation FX This work was supported by the US Army Research Office. VP acknowledges financial support from the Alexander von Humboldt Foundation. TEM was performed at the Centralized Research Facilities (CRF) at Drexel University with the assistance of Dr. Craig Johnson. We thank Dr. Vadym Mochalin (Drexel University) for the Zeta potential measurement and Professor Bastian Etzold (University of ErlangenNurnberg) for helpful comments. Kristy Jost (Drexel University) is thanked for her support in graphic NR 36 TC 8 Z9 8 U1 4 U2 26 PU AMER SCIENTIFIC PUBLISHERS PI VALENCIA PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA SN 2158-5849 EI 2158-5857 J9 MATER EXPRESS JI Mater. Express PD DEC PY 2011 VL 1 IS 4 BP 259 EP 266 DI 10.1166/mex.2011.1040 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Science & Technology - Other Topics; Materials Science GA 048LU UT WOS:000311913800001 ER PT J AU Terrill, WA AF Terrill, W. Andrew TI Richard Nixon, Great Britain and the Anglo-American Alignment in the Persian Gulf and Arabian Peninsula: Making Allies Out of Clients SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Terrill, W. Andrew] US Army War Coll, Carlisle, PA USA. RP Terrill, WA (reprint author), US Army War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD WIN PY 2011 VL 65 IS 1 BP 173 EP 174 PG 2 WC Area Studies SC Area Studies GA V31XG UT WOS:000208915700037 ER PT J AU Yu, XP Ivanic, J Memisevic, V Wallqvist, A Reifman, J AF Yu, Xueping Ivanic, Joseph Memisevic, Vesna Wallqvist, Anders Reifman, Jaques TI Categorizing Biases in High-Confidence High-Throughput Protein-Protein Interaction Data Sets SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID SACCHAROMYCES-CEREVISIAE INTERACTOME; INTERACTION NETWORKS; INTERACTION PROTEOMICS; 2-HYBRID ANALYSIS; SYSTEMS BIOLOGY; BINARY PROTEIN; YEAST; COMPLEXES; MAP; IDENTIFICATION AB We characterized and evaluated the functional attributes of three yeast high-confidence protein-protein interaction data sets derived from affinity purification/mass spectrometry, protein-fragment complementation assay, and yeast two-hybrid experiments. The interacting proteins retrieved from these data sets formed distinct, partially overlapping sets with different protein-protein interaction characteristics. These differences were primarily a function of the deployed experimental technologies used to recover these interactions. This affected the total coverage of interactions and was especially evident in the recovery of interactions among different functional classes of proteins. We found that the interaction data obtained by the yeast two-hybrid method was the least biased toward any particular functional characterization. In contrast, interacting proteins in the affinity purification/mass spectrometry and protein-fragment complementation assay data sets were over-and under-represented among distinct and different functional categories. We delineated how these differences affected protein complex organization in the network of interactions, in particular for strongly interacting complexes (e.g. RNA and protein synthesis) versus weak and transient interacting complexes (e.g. protein transport). We quantified methodological differences in detecting protein interactions from larger protein complexes, in the correlation of protein abundance among interacting proteins, and in their connectivity of essential proteins. In the latter case, we showed that minimizing inherent methodology biases removed many of the ambiguous conclusions about protein essentiality and protein connectivity. We used these findings to rationalize how biological insights obtained by analyzing data sets originating from different sources sometimes do not agree or may even contradict each other. An important corollary of this work was that discrepancies in biological insights did not necessarily imply that one detection methodology was better or worse, but rather that, to a large extent, the insights reflected the methodological biases themselves. Consequently, interpreting the protein interaction data within their experimental or cellular context provided the best avenue for overcoming biases and inferring biological knowledge. Molecular & Cellular Proteomics 10: 10.1074/mcp.M111.012500, 1-17, 2011. C1 [Yu, Xueping; Ivanic, Joseph; Memisevic, Vesna; Wallqvist, Anders; Reifman, Jaques] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol HPC Software Applicat Inst, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 FU U.S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland FX This work was supported by the Military Operational Medicine Research Program of the U. S. Army Medical Research and Materiel Command, Ft. Detrick, Maryland, as part of the U.S. Army's Network Science Initiative. NR 58 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 1535-9476 EI 1535-9484 J9 MOL CELL PROTEOMICS JI Mol. Cell. Proteomics PD DEC PY 2011 VL 10 IS 12 AR M111.012500 DI 10.1074/mcp.M111.012500 PG 17 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 865DF UT WOS:000298290300026 PM 21876202 ER PT J AU Myers, TM Hamilton, LR AF Myers, Todd M. Hamilton, Lindsey R. TI Delayed match-to-sample performance in African green monkeys (Chlorocebus aethiops sabaeus): effects of benzodiazepine, cholinergic, and anticholinergic drugs SO BEHAVIOURAL PHARMACOLOGY LA English DT Article DE African green monkeys; behavioral pharmacology; delayed match-to-sample; macaques; nonhuman primate comparative psychology; operant touch screen response; visual attention and short-term memory ID RHESUS-MONKEYS; WORKING-MEMORY; RECOGNITION MEMORY; NONHUMAN-PRIMATES; SQUIRREL-MONKEYS; CEBUS-APELLA; DNA EVIDENCE; TERM-MEMORY; SCOPOLAMINE; PHYSOSTIGMINE AB Delayed match-to-sample (DMTS) procedures are among the most commonly used attention and memory tasks in behavioral pharmacology and have been utilized in a variety of species. Although macaque species such as the rhesus and cynomolgus macaque are often used for such studies, availability and disease transmission raise concerns over their use. The present study investigated whether the African green monkey might function as a suitable alternative by evaluating operant performance on a DMTS task and comparing this species' response to some commonly used drugs (0.025-0.075 mg/kg physostigmine, 0.0033-0.03 mg/kg scopolamine, 0.014-0.44 mg/kg atropine, 0.125-1.0 mg/kg midazolam, and 0.125-2.0 mg/kg diazepam) to the responses previously reported in macaques. Results demonstrated that African green monkeys are capable of learning and performing a DMTS task, and dose-effect functions for behavioral pharmacology were quite similar to those reported for rhesus macaques and other nonhuman primate species. Thus, the African green monkey may function as a suitable alternative to macaque species in behavioral pharmacology research. Behavioural Pharmacology 22:814-823 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. C1 [Myers, Todd M.; Hamilton, Lindsey R.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Myers, TM (reprint author), USA, Med Res Inst Chem Def, Analyt Toxicol Div, Neurobehav Toxicol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM Todd.Myers2@us.army.mil FU Defense Threat Reduction Agency, Medical ST Division FX This research was supported by the Defense Threat Reduction Agency, Medical S&T Division. NR 43 TC 2 Z9 2 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0955-8810 J9 BEHAV PHARMACOL JI Behav. Pharmacol. PD DEC PY 2011 VL 22 IS 8 BP 814 EP 823 DI 10.1097/FBP.0b013e32834d6292 PG 10 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA 844XG UT WOS:000296784900011 PM 22027713 ER PT J AU Betts, AM Banks, KP Solberg, AO AF Betts, Aaron M. Banks, Kevin P. Solberg, Agnieszka O. TI Unsuspected Perforated Richter Hernia in the Inguinal Canal Detected by F-18 FDG PET/CT SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE Richter hernia; inguinal hernia; abscess; PET/CT; occult malignancy ID UNKNOWN ORIGIN; FEVER AB An 86-year-old man presented with fatigue and weight loss. Combined F-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) demonstrated a heterogeneous soft-tissue mass continuous with the small bowel in the left inguinal region, with marked hypermetabolic activity on PET images. Physical examination of the left groin demonstrated a previously unidentified nonreducible, tender mass. Surgical exploration revealed a perforated Richter hernia in the internal inguinal ring with adjacent groin abscess. Pathologic evaluation confirmed these findings without underlying malignancy. C1 [Betts, Aaron M.; Banks, Kevin P.; Solberg, Agnieszka O.] Brooke Army Med Ctr, Dept Radiol, Nucl Med Serv, Ft Sam Houston, TX 78234 USA. RP Betts, AM (reprint author), 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM aaron.betts@amedd.army.mil NR 11 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD DEC PY 2011 VL 36 IS 12 BP 1118 EP 1119 DI 10.1097/RLU.0b013e3182335ddf PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 845BC UT WOS:000296796800028 PM 22064085 ER PT J AU Causey, MW Johnson, EK Miller, S Martin, M Maykel, J Steele, SR AF Causey, Marlin W. Johnson, Eric K. Miller, Seth Martin, Matthew Maykel, Justin Steele, Scott R. TI The Impact of Obesity on Outcomes Following Major Surgery for Crohn's Disease: An American College of Surgeons National Surgical Quality Improvement Program Assessment SO DISEASES OF THE COLON & RECTUM LA English DT Article; Proceedings Paper CT Annual Scientific Meeting of the American-Society-of-Colon-and-Rectal-Surgeons CY MAY 14-19, 2011 CL Vancouver, CANADA SP Amer Soc Colon & Rectal Surg DE National Surgical Quality Improvement Program; Obesity; Crohn's disease; Colectomy ID BODY-MASS INDEX; POSTOPERATIVE COMPLICATIONS; PERIOPERATIVE OUTCOMES; PREVALENCE; CANCER; HEART; RISK AB BACKGROUND: Whereas Crohn's disease is traditionally thought to represent a wasting disease, little is currently known about the incidence and impact of obesity in this patient cohort. OBJECTIVE: This study aimed to evaluate the perioperative outcomes in patients with Crohn's disease who were obese vs those who were not obese undergoing major abdominal surgery. DESIGN: This study is a retrospective review of the American College of Surgeons National Surgical Quality Improvement Program database (2005-2008). Risk-adjusted 30-day outcomes were assessed by the use of regression modeling accounting for patient characteristics, comorbidities, and surgical procedures. PATIENTS: Included were all patients with Crohn's disease who were undergoing abdominal operations. MAIN OUTCOME MEASURE: The primary outcomes measured were short-term perioperative outcomes. Obesity was defined as a BMI of 30 or greater. RESULTS: We identified 2319 patients (mean age, 41.6 y; 55% female). Of these patients, 379 (16%) met obesity criteria, 2% were morbidly obese, and 0.3% were super obese. Rates of obesity significantly increased each year over the study period. Twenty-five percent of the surgeries were performed laparoscopically (obese 21% vs nonobese 26%). Six percent were emergent, with no difference in patients with obesity. Operative times were significantly longer among patients with obesity (177 min) compared with patients who were not obese (164 min). After adjusting for differences in comorbidities and steroid use, overall perioperative morbidity was significantly higher in the obese cohort (32% vs 22% nonobese; OR 1.9). In addition, the rates of postoperative complications increased directly with rising BMI. Irrespective of procedure type, the patients who were obese were significantly more likely to experience wound infections (OR 1.7), which increased even further in patients who were morbidly obese (BMI >40; OR 7.1). By specific operation, postoperative morbidity was increased in patients with obesity following colectomies with primary anastomosis for both open and laparoscopic approaches (OR 2.9 and OR 3.8). Cardiac, pulmonary, and renal complications as well as overall mortality did not differ significantly based on BMI. LIMITATIONS: This study was limited by being a retrospective review, and by using data limited to the American College of Surgeons National Surgical Quality Improvement Program database. CONCLUSION: Increasing BMI adversely affects perioperative morbidity in patients with Crohn's disease. C1 [Causey, Marlin W.; Miller, Seth; Martin, Matthew; Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA USA. [Johnson, Eric K.] Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. [Maykel, Justin] Univ Massachusetts, Sch Med, Dept Surg, UMass Mem Med Ctr, Worcester, MA USA. RP Steele, SR (reprint author), 9606 Piperhill Dr SE, Olympia, WA 98513 USA. EM harkersteele@mac.com RI Martin, Matthew/B-2676-2014 OI Martin, Matthew/0000-0002-9169-9069 NR 25 TC 32 Z9 32 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0012-3706 J9 DIS COLON RECTUM JI Dis. Colon Rectum PD DEC PY 2011 VL 54 IS 12 BP 1488 EP 1495 DI 10.1097/DCR.0b013e3182342ccb PG 8 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 845VW UT WOS:000296854300005 PM 22067176 ER PT J AU Guan, PC Chi, SW Chen, JS Slawson, TR Roth, MJ AF Guan, P. C. Chi, S. W. Chen, J. S. Slawson, T. R. Roth, M. J. TI Semi-Lagrangian reproducing kernel particle method for fragment-impact problems SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE Semi-Lagrangian; Reproducing kernel particle method; Penetration; Meshfree ID CONFORMING NODAL INTEGRATION; LARGE-DEFORMATION ANALYSIS; MESH-FREE METHODS; FINITE-ELEMENTS; GALERKIN AB Fragment-impact problems exhibit excessive material distortion and complex contact conditions that pose considerable challenges in mesh based numerical methods such as the finite element method (FEM). A semi-Lagrangian reproducing kernel particle method (RKPM) is proposed for fragment-impact modeling to alleviate mesh distortion difficulties associated with the Lagrangian FEM and to minimize the convective transport effect in the Eulerian or Arbitrary Lagrangian Eulerian FEM. A stabilized non-conforming nodal integration with boundary correction for the semi-Lagrangian RKPM is also proposed. Under the framework of semi-Lagrangian RKPM, a kernel contact algorithm is introduced to address multi-body contact. Stability analysis shows that temporal stability of the kernel contact algorithm is related to the velocity gradient between two contacting bodies. The performance of the proposed methods is examined by numerical simulation of penetration processes. Published by Elsevier Ltd. C1 [Chi, S. W.; Chen, J. S.] Univ Calif Los Angeles, Dept Civil & Environm Engn, Los Angeles, CA 90095 USA. [Guan, P. C.] Natl Taiwan Ocean Univ, Computat & Simulat Ctr, Keelung, Taiwan. [Guan, P. C.] Natl Taiwan Ocean Univ, Dept Syst Engn & Naval Architecture, Keelung, Taiwan. [Slawson, T. R.; Roth, M. J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Chen, JS (reprint author), Univ Calif Los Angeles, Dept Civil & Environm Engn, Los Angeles, CA 90095 USA. EM jschen@seas.ucla.edu FU U.S. Army Engineer Research and Development Center [W912HZ-07-C-0019:P00001] FX The support of this work by U.S. Army Engineer Research and Development Center under the contract W912HZ-07-C-0019:P00001 to UCLA is very much appreciated. Permission to publish was granted by Director, Geotechnical and Structures Laboratory. NR 28 TC 30 Z9 31 U1 0 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD DEC PY 2011 VL 38 IS 12 BP 1033 EP 1047 DI 10.1016/j.ijimpeng.2011.08.001 PG 15 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 843OE UT WOS:000296680700011 ER PT J AU Hayes, SM Buchler, N Stokes, J Kragel, J Cabeza, R AF Hayes, Scott M. Buchler, Norbou Stokes, Jared Kragel, James Cabeza, Roberto TI Neural Correlates of Confidence during Item Recognition and Source Memory Retrieval: Evidence for Both Dual-process and Strength Memory Theories SO JOURNAL OF COGNITIVE NEUROSCIENCE LA English DT Article ID MEDIAL TEMPORAL-LOBE; EPISODIC MEMORY; PARIETAL CORTEX; PREFRONTAL CORTEX; RECOLLECTION; FAMILIARITY; FMRI; LESIONS; DISSOCIATION; INFORMATION AB Although the medial-temporal lobes (MTL), PFC, and parietal cortex are considered primary nodes in the episodic memory network, there is much debate regarding the contributions of MTL, PFC, and parietal subregions to recollection versus familiarity (dual-process theory) and the feasibility of accounts on the basis of a single memory strength process (strength theory). To investigate these issues, the current fMRI study measured activity during retrieval of memories that differed quantitatively in terms of strength (high vs. low-confidence trials) and qualitatively in terms of recollection versus familiarity (source vs. item memory tasks). Support for each theory varied depending on which node of the episodic memory network was considered. Results from MTL best fit a dual-process account, as a dissociation was found between a right hippocampal region showing high-confidence activity during the source memory task and bilateral rhinal regions showing high-confidence activity during the item memory task. Within PFC, several left-lateralized regions showed greater activity for source than item memory, consistent with recollective orienting, whereas a right-lateralized ventrolateral area showed low-confidence activity in both tasks, consistent with monitoring processes. Parietal findings were generally consistent with strength theory, with dorsal areas showing low-confidence activity and ventral areas showing high-confidence activity in both tasks. This dissociation fits with an attentional account of parietal functions during episodic retrieval. The results suggest that both dual-process and strength theories are partly correct, highlighting the need for an integrated model that links to more general cognitive theories to account for observed neural activity during episodic memory retrieval. C1 [Hayes, Scott M.] VA Boston Healthcare Syst, Memory Disorders Res Ctr, Boston, MA 02130 USA. [Hayes, Scott M.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA. [Hayes, Scott M.] VA Boston Healthcare Syst, Neuroimaging Res Ctr, Boston, MA 02130 USA. [Buchler, Norbou] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Stokes, Jared; Kragel, James; Cabeza, Roberto] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27706 USA. [Cabeza, Roberto] Duke Univ, Med Ctr, Brain Imaging & Anal Ctr, Durham, NC 27706 USA. [Cabeza, Roberto] Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27706 USA. RP Hayes, SM (reprint author), VA Boston Healthcare Syst, Memory Disorders Res Ctr 151A, 150 S Huntington Ave, Boston, MA 02130 USA. EM smhayes@bu.edu FU National Institutes of Health; National Institute on Aging (NIA) [R01 AG019731, R56 AG23770, F32 AG029738]; Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research & Development Service [E7822W] FX The authors thank Michael White and Micah Adams for assistance with data collection and Allen Song for providing technical assistance with MRI data acquisition. We would also like to thank two anonymous reviewers for their helpful comments. This work was supported by the National Institutes of Health, the National Institute on Aging (NIA; grants R01 AG019731 and R56 AG23770 awarded to R. C. and grant F32 AG029738 awarded to S. M. H.) and the Department of Veterans Affairs, Veterans Health Administration, Rehabilitation Research & Development Service (grant E7822W awarded to S. M. H.). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIH or NIA. NR 64 TC 22 Z9 22 U1 2 U2 11 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 0898-929X J9 J COGNITIVE NEUROSCI JI J. Cogn. Neurosci. PD DEC PY 2011 VL 23 IS 12 BP 3959 EP 3971 PG 13 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 844PB UT WOS:000296758500023 PM 21736454 ER PT J AU Stinner, DJ Krueger, CA Masini, BD Wenke, JC AF Stinner, D. J. Krueger, C. A. Masini, B. D. Wenke, J. C. TI Time-dependent effect of chlorhexidine surgical prep SO JOURNAL OF HOSPITAL INFECTION LA English DT Article DE Chlorhexidine; Surgical site infection ID POVIDONE-IODINE; SURGERY; METAANALYSIS; ANTISEPSIS AB Despite continued advances in preoperative preventive measures and aseptic technique, surgical site infections remain a problem. The purpose of this study was to evaluate the time-dependent effectiveness of chlorhexidine, a common surgical preparation solution, at various concentrations. Agar plates containing a Mueller-Hinton medium were inoculated with Staphylococcus aureus (lux) bacteria. The bacteria are genetically engineered to emit photons, allowing for quantification with a photon-counting camera system. Standardized amounts of aqueous chlorhexidine at three different concentrations (group 1:4%; group 2:2%; group 3:0.4%) were applied to the agar plates and comparisons in bacterial reduction were made. After 2 min of contact time, groups 1 and 2 had similar reductions in bacterial load with 30% bacterial load remaining in each group (P = 0.512), whereas group 3 had a significantly higher bacterial load (33%) when compared to both groups 1 and 2 (1 vs 3, P < 0.0001; 2 vs 3, P = 0.0002). The bacterial load in all three groups continued to decrease out to the final time point (1 h) with group 1 having the least amount of bacterial load remaining, 9% (P < 0.0001) and group 3 with the highest bacterial load remaining, 19% (P < 0.0001). This study demonstrates two key results: first, dilution of chlorhexidine correlates directly with its bactericidal activity; second, its effectiveness is directly related to its contact time. Based on the results of this study, the authors recommend using 4% chlorhexidine for surgical site preparation and allowing a minimum of 2 min of contact time prior to making the skin incision. Published by Elsevier Ltd on behalf of the Healthcare Infection Society. C1 [Stinner, D. J.; Krueger, C. A.; Masini, B. D.; Wenke, J. C.] USA, Inst Surg Res, Dept Regenerat Med, Ft Sam Houston, TX 78234 USA. RP Stinner, DJ (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA. OI Stinner, Daniel/0000-0002-8981-6262 NR 13 TC 9 Z9 9 U1 2 U2 7 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0195-6701 J9 J HOSP INFECT JI J. Hosp. Infect. PD DEC PY 2011 VL 79 IS 4 BP 313 EP 316 DI 10.1016/j.jhin.2011.08.016 PG 4 WC Infectious Diseases SC Infectious Diseases GA 846QL UT WOS:000296918200007 PM 22000737 ER PT J AU Meng, AD Nassar, SA Templeton, D AF Meng, Aidong Nassar, Sayed A. Templeton, Douglas TI A Novel Optical Method for Real-Time Control of Bolt Tightening SO JOURNAL OF PRESSURE VESSEL TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article DE speckle interferometry; digital speckle pattern interferometry; spatial phase shifting; bolted joint ID SPECKLE PATTERN INTERFEROMETRY; INPLANE AB A digital speckle pattern interferometry (DSPI) system is developed for the real-time measurement and monitoring of the out-of-plane surface deformation around a preloaded bolt head or nut. The proposed system is specifically developed for the dynamic control of the bolt tightening process by continuously monitoring the out-of-plane joint surface deformation that will have been independently correlated to the bolt preload. Spatial phase shifting is employed to quantitatively determine the distribution of phase data by introducing a spatial carrier fringe pattern to the speckle interferogram. This is achieved by leading the object and reference beams through two separate apertures. The configuration is also suitable for collecting the real-time surface deformation during bolt tightening. The experimental DSPI system is set-up with optical components on a vibration-isolation table. A MATLAB software is developed for image acquisition and phase data calculations that yield the out-of-plane surface deformation caused by the bolt preload. The test fixture uses an M12 steel fastener and aluminum joint. For miniature screw applications, however, a plastic joint is used. [DOI: 10.1115/1.4004797] C1 [Meng, Aidong; Nassar, Sayed A.] Oakland Univ, Dept Mech Engn, Fastening & Joining Res Inst, Rochester, MI 48309 USA. [Templeton, Douglas] USA, TARDEC, Warren, MI 48397 USA. RP Meng, AD (reprint author), Oakland Univ, Dept Mech Engn, Fastening & Joining Res Inst, Rochester, MI 48309 USA. NR 15 TC 1 Z9 1 U1 0 U2 8 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-9930 J9 J PRESS VESS-T ASME JI J. Press. Vessel Technol.-Trans. ASME PD DEC PY 2011 VL 133 IS 6 AR 061211 DI 10.1115/1.4004797 PG 5 WC Engineering, Mechanical SC Engineering GA 843FD UT WOS:000296656800011 ER PT J AU Clayton, JD Knap, J AF Clayton, J. D. Knap, J. TI Phase field modeling of twinning in indentation of transparent crystals SO MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING LA English DT Article ID SINGLE-CRYSTAL; MARTENSITIC-TRANSFORMATION; PLASTIC DEFORMATION; DISLOCATION THEORY; ELASTIC PROPERTIES; FINITE STRAIN; CALCITE; SAPPHIRE; ALPHA-AL2O3; CORUNDUM AB Continuum phase field theory is applied to study elastic twinning in calcite and sapphire single crystals subjected to indentation loading by wedge-shaped indenters. An order parameter is associated with the magnitude of stress-free twinning shear. Geometrically linear and nonlinear theories are implemented and compared, the latter incorporating neo-Hookean elasticity. Equilibrium configurations of deformed and twinned crystals are attained numerically via direct energy minimization. Results are in qualitative agreement with experimental observations: a long thin twin forms asymmetrically under one side of the indenter, the tip of the twin is sharp and the length of the twin increases with increasing load. Qualitatively similar results are obtained using isotropic and anisotropic elastic constants, though the difference between isotropic and anisotropic results is greater in sapphire than in calcite. Similar results are also obtained for nanometer-scale specimens and millimeter-scale specimens. Indentation forces are greater in the nonlinear model than the linear model because of the increasing tangent bulk modulus with increasing pressure in the former. Normalized relationships between twin length and indentation force are similar for linear and nonlinear theories at both nanometer and millimeter scales. Twin morphologies are similar for linear and nonlinear theories for indentation with a 90 degrees wedge. However, in the nonlinear model, indentation with a 120 degrees wedge produces a lamellar twin structure between the indenter and the long sharp primary twin. This complex microstructure is not predicted by the linear theory. C1 [Clayton, J. D.] USA, Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. [Knap, J.] USA, Res Lab, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, RDRL WMP B, Aberdeen Proving Ground, MD 21005 USA. EM john.d.clayton1@us.army.mil; jaroslaw.knap@us.army.mil RI Clayton, John/C-7760-2009 NR 66 TC 17 Z9 17 U1 2 U2 18 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0965-0393 EI 1361-651X J9 MODEL SIMUL MATER SC JI Model. Simul. Mater. Sci. Eng. PD DEC PY 2011 VL 19 IS 8 AR 085005 DI 10.1088/0965-0393/19/8/085005 PG 31 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 844RJ UT WOS:000296764700006 ER PT J AU Bland, CM Bookstaver, PB Thomas, S AF Bland, Christopher M. Bookstaver, P. Brandon Thomas, Sanil TI Successful re-challenge of daptomycin therapy after initial rhabdomyolysis with co-administration of simvastatin SO INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS LA English DT Letter ID STAPHYLOCOCCUS-AUREUS C1 [Bland, Christopher M.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. [Bland, Christopher M.] Univ Georgia, Coll Pharm, Athens, GA 30602 USA. [Bookstaver, P. Brandon] S Carolina Coll Pharm, Dept Clin Pharm & Outcomes Sci, Columbia, SC USA. [Thomas, Sanil] Infect Dis Consultants, Gainesville, FL 32608 USA. RP Bland, CM (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA. EM chris.bland@us.army.mil NR 5 TC 2 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0924-8579 J9 INT J ANTIMICROB AG JI Int. J. Antimicrob. Agents PD DEC PY 2011 VL 38 IS 6 BP 549 EP 550 DI 10.1016/j.ijantimicag.2011.08.003 PG 3 WC Infectious Diseases; Microbiology; Pharmacology & Pharmacy SC Infectious Diseases; Microbiology; Pharmacology & Pharmacy GA 842HR UT WOS:000296588200018 PM 21958456 ER PT J AU Wang, Y Wei, YL Oguntayo, S Jensen, N Doctor, BP Nambiar, MP AF Wang, Ying Wei, Yanling Oguntayo, Samuel Jensen, Neil Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI [ plus ]-Huperzine A Protects Against Soman Toxicity in Guinea Pigs SO NEUROCHEMICAL RESEARCH LA English DT Article DE Neuroprotection; Chemical warfare; Huperzine A; Acetylcholinesterase; Seizure ID INDUCED OXIDATIVE INJURY; AGENT-INDUCED SEIZURES; SYNTHETIC HUPERZINE-A; BETA-AMYLOID PEPTIDE; RAT CEREBRAL-CORTEX; NERVE GROWTH-FACTOR; FUNCTION IN-VITRO; PC12 CELLS; NMDA RECEPTOR; INHIBITION AB The chemical warfare nerve agent (CWNA) soman irreversibly inhibits acetylcholinesterase (AChE) causing seizure, neuropathology and neurobehavioral deficits. Pyridostigmine bromide (PB), the currently approved pretreatment for soman, is a reversible AChE inhibitor that does not cross the blood-brain barrier (BBB) to protect against central nervous system damage. [-]-Huperzine A, a natural reversible AChE inhibitor, rapidly passes through the BBB and has numerous neuroprotective properties that are beneficial for protection against soman. However, [-]-Huperzine A is toxic at higher doses due to potent AChE inhibition which limits the utilization of its neuroprotective properties. [+]-Huperzine A, a synthetic stereoisomer of [-]-Huperzine A and a weak inhibitor of AChE, is non-toxic. In this study, we evaluated the efficacy of [+]-Huperzine A for protection against soman toxicity in guinea pigs. Pretreatments with [+]-Huperzine A, i.m., significantly increased the survival rate in a dose-dependent manner against 1.2x LD(50) soman exposures. Behavioral signs of soman toxicity were significantly reduced in 20 and 40 mg/kg [+]-Huperzine A treated animals at 4 and 24 h compared to vehicle and PB controls. Electroencephalogram (EEG) power spectral analysis showed that [+]-Huperzine A significantly reduces soman-induced seizure compared to PB. [+]-Huperzine A (40 mg/kg) preserved higher blood and brain AChE activity compared to PB in soman exposed animals. These data suggest that [+]-Huperzine A protects against soman toxicity stronger than PB and warrant further development as a potent medical countermeasure against CWNA poisoning. C1 [Wang, Ying; Wei, Yanling; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Jensen, Neil] US Army, Collaborat Res Facil, Med Res Inst Chem Def, Aberdeen, MD 21010 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Blast Induced Neurotrauma Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@us.army.mil FU Defense Threat Reduction Agency (DTRA) [1.E0003_08_WR_C] FX This work was supported by funding from Defense Threat Reduction Agency (DTRA) Grant #1.E0003_08_WR_C. The technical assistance from Collaborative Research Facility, USAMRICD is greatly acknowledged. NR 49 TC 8 Z9 8 U1 2 U2 4 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-3190 J9 NEUROCHEM RES JI Neurochem. Res. PD DEC PY 2011 VL 36 IS 12 BP 2381 EP 2390 DI 10.1007/s11064-011-0564-5 PG 10 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 841MN UT WOS:000296516500023 PM 21822920 ER PT J AU Coronges, K Stacy, AW Valente, TW AF Coronges, Kathryn Stacy, Alan W. Valente, Thomas W. TI Social network influences of alcohol and marijuana cognitive associations SO ADDICTIVE BEHAVIORS LA English DT Article DE Social network analysis; Implicit cognition; Alcohol; Marijuana; Social contagion; Intervention ID IMPLICIT; STEREOTYPES; ACTIVATION; ADDICTION; RETRIEVAL; COHESION; BEHAVIOR AB Decision-making is a social process whereby behaviors are often driven by social influences and social consequences. Research shows that social context also plays an integral role in decision-making processes. In particular, evidence suggests that implicit or non-conscious cognitions are linked to social information in memory and that implicit attitudes can be communicated and assimilated between people on an unconscious level. This study assesses social contagion of implicit cognitions regarding alcohol and marijuana among high school friend networks. Data are from an evidence-based drug education program delivered by either a health educator or by nominated class leaders over a 3-month period. Implicit attitudes were found to be susceptible to social influences, particularly for alcohol. Surprisingly, social contagion was stronger for cognitions than for behaviors. In addition, results support prior research that has found that implicit attitudes are not entirely stable and may be more susceptible to change than are behaviors. Public health initiatives to engender behavioral change could be facilitated by targeting flexible cognitive associations within existing social network structures. Published by Elsevier Ltd. C1 [Coronges, Kathryn; Stacy, Alan W.; Valente, Thomas W.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Coronges, K (reprint author), US Mil Acad, Dept Behav Sci & Leadership, 601 Cullum Rd,Thayer Hall,Room 282G, West Point, NY 10996 USA. EM kcoronges@gmail.com RI Reis, Aline/G-9573-2012; Stacy, Alan/G-5406-2016 FU National Institute on Drug Abuse [DA16094] FX This work was funded by grant #DA16094 from the National Institute on Drug Abuse. NIDA had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. NR 24 TC 13 Z9 15 U1 2 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0306-4603 J9 ADDICT BEHAV JI Addict. Behav. PD DEC PY 2011 VL 36 IS 12 BP 1305 EP 1308 DI 10.1016/j.addbeh.2011.07.008 PG 4 WC Psychology, Clinical; Substance Abuse SC Psychology; Substance Abuse GA 836LZ UT WOS:000296114500029 PM 21872402 ER PT J AU Tumuluri, K Alvarado, JL Taherian, H Marsh, C AF Tumuluri, Kalpana Alvarado, Jorge L. Taherian, Hessam Marsh, Charles TI Thermal performance of a novel heat transfer fluid containing multiwalled carbon nanotubes and microencapsulated phase change materials SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE Microencapsulated phase change materials; Multi-walled carbon nanotubes; Transient hot wire; Enhanced heat transfer fluid; Turbulent flow; Thermal conductivity ID CHANGE MATERIAL SUSPENSIONS; CHANGE MATERIAL SLURRIES; AQUEOUS SUSPENSIONS; NANOFLUIDS; CONDUCTIVITY; FLOW AB Three new heat transfer fluids consisting of combinations of multi-walled carbon nanotubes (MWCNT) and microencapsulated phase change materials (MPCMs) were formulated, and tested in a turbulent flow heat transfer loop. Stable nanofluids have been prepared using different sizes of multi-walled carbon nanotubes and their thermal properties like thermal conductivity, viscosity and heat transfer coefficient have been measured. Microencapsulated phase change material slurries containing octadecane as phase change material have been tested to determine their durability and viscosity. A blend of MPCM slurry with MWCNT nanofluid has also been prepared to form a new heat transfer fluid that exhibits unique thermophysical properties including non-Newtonian viscous behavior. Heat transfer experiments have also been conducted to determine heat transfer coefficient and pressure drop values of the MWCNT nanofluids, MPCM slurries, and blends of MWCNT with MPCM under turbulent flow and constant heat flux conditions. The heat transfer results of the MPCM slurry containing octadecane was in good agreement with the published results. A maximum thermal conductivity enhancement of 8.1% was obtained for MWCNTs with diameter of 60-100 nm and length 0.5-40 mu m. Heat transfer results indicate that MWCNT nanofluid exhibits a convective heat transfer enhancement in the range of 20-25% in turbulent flow conditions. The blend of MPCMs and MWCNTs was highly viscous and displayed a non-Newtonian shear thinning behavior. Due to its high viscosity, the blend exhibited laminar behavior and lower heat transfer rate, though the maximum local heat transfer coefficient achieved by the blend was comparable to that obtained with MPCM slurry alone. The pressure drop of the blend was also lower than that of the MWCNT nanofluid. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Alvarado, Jorge L.] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Tumuluri, Kalpana] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Taherian, Hessam] Univ Alabama, Dept Mech Engn, Birmingham, AL 35294 USA. [Marsh, Charles] USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Alvarado, JL (reprint author), 3367 TAMU, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu OI Taherian, Hessam/0000-0002-0386-3173; Alvarado, Jorge/0000-0002-4059-6588 FU California Energy Commission FX The authors would like to express their deepest thanks to Guillermo Soriano, Mansuck Kim and Chan Hyun Park from Texas A&M University. The project was funded by the California Energy Commission. NR 32 TC 26 Z9 30 U1 5 U2 45 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD DEC PY 2011 VL 54 IS 25-26 BP 5554 EP 5567 DI 10.1016/j.ijheatmasstransfer.2011.07.031 PG 14 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 835KM UT WOS:000296035300042 ER PT J AU Izvekov, S Chung, PW Rice, BM AF Izvekov, Sergei Chung, Peter W. Rice, Betsy M. TI Non-equilibrium molecular dynamics simulation study of heat transport in hexahydro-1,3,5-trinitro-s-triazine (RDX) SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE RDX; Molecular dynamics simulation; Atomistic force field; Thermal conductivity; Explosive ID LATTICE THERMAL-CONDUCTIVITY; CYCLOTRIMETHYLENE-TRINITRAMINE; FORCE-FIELD; PART I; CRYSTALS; HMX; DECOMPOSITION; EXPLOSIVES; SYSTEMS; LIQUID AB The direct estimation of thermal conductivity in solids using the constant flux non-equilibrium molecular dynamics (NEMD) simulation method has proven to be difficult with significant differences still existing for various, even simple, systems. The application of NEMD to study the thermal transport in molecular solids was rarely attempted. We report the first application of NEMD based on the Ikeshoji and Hafskjold (NEMD-IH) scheme to study the thermal conductivity of crystalline hexahydro-1,3,5-trinitro-s-triazine (RDX), an important energetic material, at temperatures T = 230, 275, and 300 K for different sample sizes and different crystallographic directions. We found that the size effects arising from a finite distance between sources of heat in the NEMD-IH simulation show a well-defined linear dependence on the inverse of the sample length within the errors of simulation. The thermal conductivity exhibits anisotropy with the largest value found along the [0 0 1] crystallographic direction and the smallest value along the [0 1 0] direction. The extrapolated value of the directionally averaged thermal conductivity coefficient (kappa) over bar to the sample of infinite length (e.g. 0.355 W/Km at T = 300 K) is higher, but still in reasonable agreement with existing experimental data for powdered samples. The NEMD-IH heat transport properties were reproduced in a broad range of values of heat flux and sizes of heat source regions. Surprisingly, the thermal conductivity coefficient at T = 275 K is found to be higher by about 13% than at T = 300 K and 230 K, which may suggest a location of the temperature maximum above 230 K. A similar location of the low temperature peak was reported from experiments on powdered samples of RDX. Through the use of additional calculations based on the Green-Kubo approach, we discuss the possible origins of such a behavior in the NEMD-IH approach. Published by Elsevier Ltd. C1 [Izvekov, Sergei] USA, Res Lab, RDRL WML B ATTN Dr Sergei Izvekov, Aberdeen Proving Ground, MD 21005 USA. RP Izvekov, S (reprint author), USA, Res Lab, RDRL WML B ATTN Dr Sergei Izvekov, Aberdeen Proving Ground, MD 21005 USA. EM sergiy.izvyekov.civ@mail.mil FU DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions; US Army Research Laboratory FX Calculations were performed at the ERDC and NAVY DoD Supercomputing Resource Centers (DSRCs) of the Department of Defense High Performance Computing Modernization Program. This research was supported by the DoD High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. This project was supported in part by an appointment to the Internship/Research Participation Program for the US Army Research Laboratory administered by the Oak Ridge Institute for Science and Education. NR 58 TC 13 Z9 13 U1 1 U2 22 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD DEC PY 2011 VL 54 IS 25-26 BP 5623 EP 5632 DI 10.1016/j.ijheatmasstransfer.2011.06.040 PG 10 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 835KM UT WOS:000296035300049 ER PT J AU Oh, SR Sun, J Dobbs, H King, J AF Oh, So-Ryeok Sun, Jing Dobbs, Herb King, Joel TI Performance Evaluation of Solid Oxide Fuel Cell Engines Integrated With Single/Dual-Spool Turbochargers SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article ID TURBINE HYBRID SYSTEM AB This study investigates the performance and operating characteristics of 5kW-class solid oxide fuel cell and gas turbine (SOFC/GT) hybrid systems for two different configurations, namely single- and dual- spool gas turbines. Both single and dual spool turbo-chargers are widely used in the gas turbine industry. Even though their operation is based on the same physical principles, their performance characteristics and operation parameters vary considerably due to different designs. The implications of the differences on the performance of the hybrid SOFC/GT have not been discussed in literature, and will be the topic of this paper. Operating envelops of single and dual shaft systems are identified and compared. Performance in terms of system efficiency and load following is analyzed. Sensitivities of key variables such as power, SOFC temperature, and GT shaft speed to the control inputs (namely, fuel flow, SOFC current, generator load) are characterized, all in an attempt to gain insights on the design implication for the single and dual shaft SOFC/GT systems. Dynamic analysis are also performed for part load operation and load transitions, which shed lights for the development of safe and optimal control strategies. [DOI: 10.1115/1.4004471] C1 [Oh, So-Ryeok; Sun, Jing] Univ Michigan, Ann Arbor, MI 48109 USA. [Dobbs, Herb; King, Joel] USA, TARDEC, Warren, MI 48397 USA. RP Oh, SR (reprint author), Univ Michigan, Ann Arbor, MI 48109 USA. EM srohum@umich.edu; jingsun@umich.edu FU U.S. Army TARDEC; U.S. Navy under NEEC (Naval Engineering Education Center) FX This work is funded in part by U.S. Army TARDEC and in part by U.S. Navy under NEEC (Naval Engineering Education Center). NR 15 TC 0 Z9 0 U1 0 U2 3 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X EI 1551-6989 J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD DEC PY 2011 VL 8 IS 6 AR 061020 DI 10.1115/1.4004471 PG 12 GA 829YQ UT WOS:000295623400020 ER PT J AU Sheremet, A Kaihatu, JM Su, SF Smith, ER Smith, JM AF Sheremet, A. Kaihatu, J. M. Su, S. -F. Smith, E. R. Smith, J. M. TI Modeling of nonlinear wave propagation over fringing reefs SO COASTAL ENGINEERING LA English DT Article DE Nonlinear waves; Steep slopes; Reef waves ID SURFACE GRAVITY-WAVES; INFRAGRAVITY WAVES; SHALLOW-WATER; CORAL-REEFS; SET-UP; DIRECTIONAL SPECTRA; RUN-UP; TRANSFORMATION; BEACH; EVOLUTION AB The applicability of existing nonlinear (triad) spectral models for steep slopes (0.1-0.2) characteristic of reef environments was investigated, using both deterministic (phase-resolving) and stochastic (phased-averaged) formulations. Model performance was tested using laboratory observations of unidirectional wave transformation over steep and smooth bathymetry profiles. The models, developed for mild slopes, were implemented with minimal modifications (the inclusion of breaking parametrizations and linear steep-slope corrections) required by laboratory data. The deterministic model produced typically more accurate predictions than the stochastic one, but the phase averaged formulation proved fast enough to allow for an inverse modeling search for the optimal breaking parametrization. The effects of the additional assumptions of the stochastic approach resulted in a slower than observed evolution of the infragravity band. Despite the challenge posed by the fast wave evolution and energetic breaking characteristic to the steep reef slopes, both formulations performed overall well, and should be considered as good provisional candidates for use in numerical investigation of wave-current interaction processes on steep reefs. Published by Elsevier B.V. C1 [Sheremet, A.; Su, S. -F.] U Florida, Gainesville, FL 32611 USA. [Kaihatu, J. M.] Texas A&M U, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Smith, E. R.; Smith, J. M.] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Sheremet, A (reprint author), U Florida, 365 Weil Hall,POB 116580, Gainesville, FL 32611 USA. EM alex@coastal.ufl.edu RI Kaihatu, James/H-7561-2016 OI Kaihatu, James/0000-0002-9277-6409 FU Engineer Research and Development Center, U.S. Army Corps of Engineers FX This research was supported by the Surge and Wave Island Modeling Studies Project, Coastal Field Data Collection Program, Engineer Research and Development Center, U.S. Army Corps of Engineers. Permission to publish this work was granted by the Chief of Engineers, U.S. Army Corps of Engineers. We are grateful to Prof. Stephen Monismith for many illuminating discussions on the topic of wave-current interaction on reefs. NR 56 TC 23 Z9 24 U1 3 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD DEC PY 2011 VL 58 IS 12 BP 1125 EP 1137 DI 10.1016/j.coastaleng.2011.06.007 PG 13 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 820DR UT WOS:000294886200004 ER PT J AU Kelley, TD Cassenti, DN AF Kelley, Troy D. Cassenti, Daniel N. TI Theoretical explorations of cognitive robotics using developmental psychology SO NEW IDEAS IN PSYCHOLOGY LA English DT Article DE Development; Robotics; Cognition; Cognitive modeling ID CONNECTIONIST MODELS; INFANTS AB How can cognitive robotics inform developmental psychology researchers and what can developmental psychology tell us about creating robots? More importantly, how can cognitive robotics and developmental psychology nourish each other to become a symbiotic relationship for future research? We address the theoretical underpinnings of developmental change using a cognitive architecture implemented on a robotic system and how our theories of knowledge representation relate to critical periods of infant development. Next, we will show how descriptive theories of cognitive development, specifically Zelazo's Levels of Consciousness (LOC: Zelazo, 2000, 2004; Zelazo & Jacques, 1996), can be mapped onto a computational cognitive architecture (ACTR; Anderson & Lebiere, 1998). Following our discussion of Zelazo's theory, we will apply the ACT-R architecture specifically to the problem of object permanence. Finally, we will address how cognitive robotics can serve as a computational proving ground of developmental psychology for future research. Published by Elsevier Ltd. C1 [Kelley, Troy D.; Cassenti, Daniel N.] USA, Res Lab, Human Res & Engn Directorate, AMSRD ARL HR SE, Aberdeen Proving Ground, MD 21005 USA. RP Kelley, TD (reprint author), USA, Res Lab, Human Res & Engn Directorate, AMSRD ARL HR SE, Aberdeen Proving Ground, MD 21005 USA. EM tkelley@arl.army.mil; dcassenti@arl.army.mil NR 27 TC 2 Z9 2 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0732-118X J9 NEW IDEAS PSYCHOL JI New Ideas Psychol. PD DEC PY 2011 VL 29 IS 3 SI SI BP 228 EP 234 DI 10.1016/j.newideapsych.2009.07.002 PG 7 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 784AW UT WOS:000292127000004 ER PT J AU Konrad, C Berge, H Fuerstenberg, R Steff, K Olsen, T Guyenet, J AF Konrad, Christopher Berge, Hans Fuerstenberg, Robert Steff, Kate Olsen, Theresa Guyenet, Julie TI Channel Dynamics in the Middle Green River, Washington, from 1936 to 2002 SO NORTHWEST SCIENCE LA English DT Article ID FLOODPLAIN DYNAMICS; RIPARIAN; SYSTEMS; DAMS AB Alluvial rivers are dynamic elements of the landscape in the Pacific Northwest. They expand, contract, and migrate across the bottom of valleys in response to changing flow and vegetation. Channel dynamics fundamentally structure river and floodplain ecosystems. Human activities that affect channel migration-including river regulation, channel revetments, and land use-have the potential for impacting river ecosystems. Active channel width and lateral movement of the active channel centerline was analyzed in 17 km valley segment of the middle Green River in western Washington from aerial photographs for 26 years of unregulated flows (1936-1961) and 41 years of flood regulation by Howard Hansen Dam. Area-based measures proved more robust for characterizing channel dynamics than cross-sectional measurements, though cross-sectional measurements are useful for resolving local processes. Prior to regulation from 1936 to 1961, the active channel width varied from 82 in to 120 in (median 94 in) and the channel migrated laterally a total of 68 m. After flood regulation from 1961 to 2002, the active channel width was generally smaller, varying from 84 m to 52 m (median 69 in) and the channel migrated 48 in. Streamflow greater than about 250 m(3)/s are most effective for forcing migration and have been reduced since dam construction. The river has re-occupied areas with increasing frequency since dam construction. High flows are essential to create new channel and floodplain habitats in the middle Green River, but land cover/use and revetments in the river corridor are also influential factors for maintaining channel dynamics. C1 [Konrad, Christopher; Olsen, Theresa; Guyenet, Julie] US Geol Survey, Tacoma, WA 98402 USA. [Konrad, Christopher] Nature Conservancy, Seattle, WA 98101 USA. [Berge, Hans; Fuerstenberg, Robert] King Cty Dept Nat Resources, Seattle, WA 98104 USA. [Steff, Kate] US Army Corps Engineers, Seattle, WA 98134 USA. RP Konrad, C (reprint author), US Geol Survey, 934 Broadway, Tacoma, WA 98402 USA. EM cpkonrad@usgs.gov OI Konrad, Christopher/0000-0002-7354-547X FU King County Department of Natural Resources; U.S. Army Corps of Engineers Seattle District; U.S. Geological Survey Washington Water Science Center; Washington State Department of Fish and Wildlife FX This investigation was conceived and supported through a collaborative effort of King County Department of Natural Resources, U.S. Army Corps of Engineers Seattle District, U.S. Geological Survey Washington Water Science Center, and Washington State Department of Fish and Wildlife. Al Wald, David St. John, Marian Valentine, Lorin Reinelt, Curtis Degaspri, and Ken Rauscher contributed to the planning and implementation of this investigation. Reviews by Tim Abbe, Tim Beechie, Amy Draught, and Jim O'Connor substantively improved this manuscript. NR 23 TC 6 Z9 6 U1 2 U2 12 PU WASHINGTON STATE UNIV PI PULLMAN PA PO BOX 645020, PULLMAN, WA 99164-5910 USA SN 0029-344X J9 NORTHWEST SCI JI Northwest Sci. PD WIN PY 2011 VL 85 IS 1 BP 1 EP 14 DI 10.3955/046.085.0101 PG 14 WC Ecology SC Environmental Sciences & Ecology GA 734CN UT WOS:000288310900001 ER PT J AU George, SZ Childs, JD Teyhen, DS Wu, SS Wright, AC Dugan, JL Robinson, ME AF George, Steven Z. Childs, John D. Teyhen, Deydre S. Wu, Samuel S. Wright, Alison C. Dugan, Jessica L. Robinson, Michael E. TI Brief psychosocial education, not core stabilization, reduced incidence of low back pain: results from the Prevention of Low Back Pain in the Military (POLM) cluster randomized trial SO BMC MEDICINE LA English DT Article DE primary prevention; core stabilization; patient education; incidence; low back pain ID FEAR-AVOIDANCE; MUSCULOSKELETAL PAIN; CLINICAL-TRIAL; LUMBAR SPINE; INTERVENTION; EXERCISES; IMPROVE; CARE; NCT00373009; PREVALENCE AB Background: Effective strategies for the primary prevention of low back pain (LBP) remain elusive with few large-scale clinical trials investigating exercise and education approaches. The purpose of this trial was to determine whether core stabilization alone or in combination with psychosocial education prevented incidence of low back pain in comparison to traditional lumbar exercise. Methods: The Prevention of Low Back Pain in the Military study was a cluster randomized clinical study with four intervention arms and a two-year follow-up. Participants were recruited from a military training setting from 2007 to 2008. Soldiers in 20 consecutive companies were considered for eligibility (n = 7,616). Of those, 1,741 were ineligible and 1,550 were eligible but refused participation. For the 4,325 Soldiers enrolled with no previous history of LBP average age was 22.0 years (SD = 4.2) and there were 3,082 males (71.3%). Companies were randomly assigned to receive traditional lumbar exercise, traditional lumbar exercise with psychosocial education, core stabilization exercise, or core stabilization with psychosocial education, The psychosocial education session occurred during one session and the exercise programs were done daily for 5 minutes over 12 weeks. The primary outcome for this trial was incidence of low back pain resulting in the seeking of health care. Results: There were no adverse events reported. Evaluable patient analysis (4,147/4,325 provided data) indicated no differences in low back incidence resulting in the seeking of health care between those receiving the traditional exercise and core stabilization exercise programs. However, brief psychosocial education prevented low back pain episodes regardless of the assigned exercise approach, resulting in a 3.3% (95% Cl: 1.1 to 5.5%) decrease over two years (numbers needed to treat (NNT) = 30.3, 95% Cl = 18.2 to 90.9). Conclusions: Core stabilization has been advocated as preventative, but offered no such benefit when compared to traditional lumbar exercise in this trial. Instead, a brief psychosocial education program that reduced fear and threat of low back pain decreased incidence of low back pain resulting in the seeking of health care. Since this trial was conducted in a military setting, future studies are necessary to determine if these findings can be translated into civilian populations. Trial Registration: NCT00373009 at ClinicalTrials.gov - http://clinicaltrials.gov/ C1 [George, Steven Z.] Univ Florida, Dept Phys Therapy, Gainesville, FL 32610 USA. [Childs, John D.] 81st Med Grp, Dept Phys Therapy MSGS SGCUY, Biloxi, MS 39534 USA. [Childs, John D.; Teyhen, Deydre S.; Wright, Alison C.; Dugan, Jessica L.] Baylor Univ, USA, Doctoral Program Phys Therapy MCCS HMT, Army Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. [Teyhen, Deydre S.] USA, Publ Hlth Command Reg S, Ft Sam Houston, TX 78234 USA. [Wu, Samuel S.] Univ Florida, Dept Biostat, Gainesville, FL 32611 USA. [Robinson, Michael E.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA. [George, Steven Z.; Robinson, Michael E.] Univ Florida, Ctr Pain Res & Behav Hlth, Gainesville, FL 32610 USA. RP George, SZ (reprint author), Univ Florida, Dept Phys Therapy, POB 100154, Gainesville, FL 32610 USA. EM szgeorge@phhp.ufl.edu FU peer-review medical research program of the Department of Defense [PR054098]; University of Florida FX The POLM cluster randomized trial was supported by the peer-review medical research program of the Department of Defense (PR054098). All authors were independent from this funding program and the funding program played no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review or approval of the manuscript. All contributing authors had access to all study data and take final responsibility for paper submission. Publication of this article was funded in part by the University of Florida Open-Access Publishing Fund. All authors had full access to all of the data reported in the study and can take responsibility for data integrity and accuracy. NR 45 TC 30 Z9 31 U1 2 U2 16 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1741-7015 J9 BMC MED JI BMC Med. PD NOV 29 PY 2011 VL 9 AR 128 DI 10.1186/1741-7015-9-128 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 898WN UT WOS:000300773200001 PM 22126534 ER PT J AU Kogot, JM Zhang, YT Moore, SJ Pagano, P Stratis-Cullum, DN Chang-Yen, D Turewicz, M Pellegrino, PM de Fusco, A Soh, HT Stagliano, NE AF Kogot, Joshua M. Zhang, Yanting Moore, Stephen J. Pagano, Paul Stratis-Cullum, Dimitra N. Chang-Yen, David Turewicz, Marek Pellegrino, Paul M. de Fusco, Andre Soh, H. Tom Stagliano, Nancy E. TI Screening of Peptide Libraries against Protective Antigen of Bacillus anthracis in a Disposable Microfluidic Cartridge SO PLOS ONE LA English DT Article ID PROTEIN-BINDING PEPTIDES; BACTERIAL DISPLAY; POLYPEPTIDE LIBRARIES; SURFACE DISPLAY; CANCER-CELLS; AFFINITY; SPECIFICITY; MICROARRAYS; ENRICHMENT; ANTIBODY AB Bacterial surface peptide display has gained popularity as a method of affinity reagent generation for a wide variety of applications ranging from drug discovery to pathogen detection. In order to isolate the bacterial clones that express peptides with high affinities to the target molecule, multiple rounds of manual magnetic activated cell sorting ( MACS) followed by multiple rounds of fluorescence activated cell sorting (FACS) are conventionally used. Although such manual methods are effective, alternative means of library screening which improve the reproducibility, reduce the cost, reduce cross contamination, and minimize exposure to hazardous target materials are highly desired for practical application. Toward this end, we report the first semi-automated system demonstrating the potential for screening bacterially displayed peptides using disposable microfluidic cartridges. The Micro-Magnetic Separation platform (MMS) is capable of screening a bacterial library containing 3610 10 members in 15 minutes and requires minimal operator training. Using this system, we report the isolation of twenty-four distinct peptide ligands that bind to the protective antigen (PA) of Bacilus anthracis in three rounds of selection. A consensus motif WXCFTC was found using the MMS and was also found in one of the PA binders isolated by the conventional MACS/FACS approach. We compared MMS and MACS rare cell recovery over cell populations ranging from 0.1% to 0.0000001% and found that both magnetic sorting methods could recover cells down to 0.0000001% initial cell population, with the MMS having overall lower standard deviation of cell recovery. We believe the MMS system offers a compelling approach towards highly efficient, semi-automated screening of molecular libraries that is at least equal to manual magnetic sorting methods and produced, for the first time, 15-mer peptide binders to PA protein that exhibit better affinity and specificity than peptides isolated using conventional MACS/FACS. C1 [Kogot, Joshua M.; Stratis-Cullum, Dimitra N.; Pellegrino, Paul M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. [Zhang, Yanting; Pagano, Paul; Chang-Yen, David; Turewicz, Marek; de Fusco, Andre] Cynvenio Biosyst Inc, Westlake Village, CA USA. [Moore, Stephen J.; Stagliano, Nancy E.] CytomX Therapeut LLC, Santa Barbara, CA USA. [Soh, H. Tom] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA. RP Kogot, JM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA. EM dimitra.n.stratis-cullum.civ@mail.mil RI Stratis-Cullum, Dimitra/F-9363-2013 OI Stratis-Cullum, Dimitra/0000-0002-4832-6945 FU U.S. Army, through the Institute of Collaborative Biology at University of California Santa Barbara [DAAD19-03-D-0004]; U.S. Department of Energy; U.S. Army Research Laboratory; Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense [BRCALL08-Per3-P-2-0028] FX This work was supported in part by the U.S. Army, through the Institute of Collaborative Biology at University of California Santa Barbara, under grant DAAD19-03-D-0004, in part by an appointment to the Internship/Research Participation Program for the U.S. Army Research Laboratory administered by the Oak Ridge Institute for Science and Education through an agreement between the U.S. Department of Energy and the U.S. Army Research Laboratory, and in part by the Defense Threat Reduction Agency-Joint Science and Technology Office for Chemical and Biological Defense (Grant no. BRCALL08-Per3-P-2-0028). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 29 TC 13 Z9 13 U1 0 U2 16 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 28 PY 2011 VL 6 IS 11 AR e26925 DI 10.1371/journal.pone.0026925 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 863KW UT WOS:000298163400003 PM 22140433 ER PT J AU Lisal, M Brennan, JK Avalos, JB AF Lisal, Martin Brennan, John K. Avalos, Josep Bonet TI Dissipative particle dynamics at isothermal, isobaric, isoenergetic, and isoenthalpic conditions using Shardlow-like splitting algorithms SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID ENERGY-CONSERVATION; INTERACTING SYSTEMS; MOLECULAR-DYNAMICS; EXTENDED SYSTEMS; SIMULATIONS; INTEGRATORS; MODELS AB Numerical integration schemes based upon the Shardlow-splitting algorithm (SSA) are presented for dissipative particle dynamics (DPD) approaches at various fixed conditions, including a constant-enthalpy (DPD-H) method that is developed by combining the equations-of-motion for a barostat with the equations-of-motion for the constant-energy (DPD-E) method. The DPD-H variant is developed for both a deterministic (Hoover) and stochastic (Langevin) barostat, where a barostat temperature is defined to satisfy the fluctuation-dissipation theorem for the Langevin barostat. For each variant, the Shardlow-splitting algorithm is formulated for both a velocity-Verlet scheme and an implicit scheme, where the velocity-Verlet scheme consistently performed better. The application of the Shardlow-splitting algorithm is particularly critical for the DPD-E and DPD-H variants, since it allows more temporally practical simulations to be carried out. The equivalence of the DPD variants is verified using both a standard DPD fluid model and a coarse-grain solid model. For both models, the DPD-E and DPD-H variants are further verified by instantaneously heating a slab of particles in the simulation cell, and subsequent monitoring of the evolution of the corresponding thermodynamic variables as the system approaches an equilibrated state while maintaining their respective constant-energy and constant-enthalpy conditions. The original SSA formulated for systems of equal-mass particles has been extended to systems of unequal-mass particles. The Fokker-Planck equation and derivations of the fluctuation-dissipation theorem for each DPD variant are also included for completeness. (C) 2011 American Institute of Physics. [doi:10.1063/1.3660209] C1 [Lisal, Martin] Inst Chem Proc Fundamentals ASCR, E Hala Lab Thermodynam, Prague, Czech Republic. [Lisal, Martin] Univ JE Purkyne, Dept Phys, Fac Sci, Usti Nad Labem, Czech Republic. [Brennan, John K.] USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Avalos, Josep Bonet] Univ Rovira & Virgili, Dept Engn Quim, Escola Tecn Super Engn Quim ETSEQ, Tarragona, Spain. RP Lisal, M (reprint author), Inst Chem Proc Fundamentals ASCR, E Hala Lab Thermodynam, Prague, Czech Republic. EM lisal@icpf.cas.cz RI Lisal, Martin/A-8176-2011; Bonet Avalos, Josep/A-2761-2010 OI Lisal, Martin/0000-0001-8005-7143; FU Czech Science Foundation [203/08/0094]; Academy of Sciences of the Czech Republic [KAN400720701]; Internal Grant Agency of the J. E. Purkinje University [53222 15 0005 01]; Army Research Laboratory [W911NF-10-2-0039]; Office of Naval Research; Department of Defense High Performance Computing Modernization Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions; Ministerio de Educacion y Ciencia of the Spanish Government [CTQ2008-06469] FX The authors would like to thank Gabriel Stoltz (CERMICS-Ecole des Ponts ParisTech) for many valuable comments regarding the DPD-E integration scheme as well as Joshua D. Moore, Sergey Izvekov, and Betsy M. Rice (U. S. Army Research Laboratory) for insightful discussions. M. L. acknowledges support by the Czech Science Foundation (Grant No. 203/08/0094), by the Grant Programme of the Academy of Sciences of the Czech Republic "Nanotechnology for Society" (Project No. KAN400720701), and by the Internal Grant Agency of the J. E. Purkinje University (Grant No. 53222 15 0005 01). M. L. further acknowledges that this research was sponsored by the Army Research Laboratory and was accomplished under Cooperative Agreement Number W911NF-10-2-0039. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. J. K. B. acknowledges support in part by the Office of Naval Research and the Department of Defense High Performance Computing Modernization Program Software Application Institute for Multiscale Reactive Modeling of Insensitive Munitions. J. B. A. thanks the financial support from the Ministerio de Educacion y Ciencia of the Spanish Government (Project No. CTQ2008-06469). NR 49 TC 15 Z9 15 U1 4 U2 31 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD NOV 28 PY 2011 VL 135 IS 20 AR 204105 DI 10.1063/1.3660209 PG 18 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 860JM UT WOS:000297944600009 PM 22128926 ER PT J AU Hurst, FP Altieri, M Patel, PP Jindal, TR Guy, SR Sidawy, AN Agodoa, LY Abbott, KC Jindal, RM AF Hurst, Frank P. Altieri, Maria Patel, Purav P. Jindal, Tarun R. Guy, Stephen R. Sidawy, Anton N. Agodoa, Lawrence Y. Abbott, Kevin C. Jindal, Rahul M. TI Effect of Smoking on Kidney Transplant Outcomes: Analysis of the United States Renal Data System SO TRANSPLANTATION LA English DT Article DE Smoking; Smoking cessation; USRDS; Graft survival; Patient survival ID CIGARETTE-SMOKING; PATIENT SURVIVAL; HUMAN COSTS; TOBACCO USE; RECIPIENTS; NEPHROPATHY; PROGRESSION; FAILURE; RISK AB Background. Weinvestigated the effect of smoking on postkidney transplant outcomes in the United States Renal Data System. Methods. In a retrospective cohort of 41,705 adult Medicare primary renal transplant recipients in the United States Renal Data System database transplanted from January 1, 2000, to June 30, 2006, and followed through October 31, 2006, we assessed Medicare claims for smoking. The association between renal allograft loss and death and smoking as a time-dependent variable was assessed with Cox nonproportional hazards regression. Results. Of 41,705 Medicare primary adult renal transplant patients, there were 9.9% patients who had evidence of prior smoking and 4.6% patients with new claims for smoking after transplant. Incident smoking (new onset smokers) occurred at a mean of 1.29 +/- 0.88 years after transplant. In the adjusted analysis, factors associated with new smoking included male gender, history of drug or alcohol use, history of chronic obstructive pulmonary disease, and later year of transplant. Compared with never smokers, incident smoking after transplant was associated with increased risk of death-censored allograft loss (adjusted hazard ratio [AHR] 1.46 [95% confidence interval {CI}: 1.19-1.79]; P<0.001) and death (AHR 2.32 [95% CI: 1.98-2.72]; P<0.001). In a sensitivity analysis excluding patients with history of chronic obstructive pulmonary disease, similar results were obtained with increased risk of death-censored allograft loss (AHR 1.43 [95% CI: 1.16-1.76]; P=0.001) and death (AHR 2.26 [95% CI: 1.91-2.66]; P<0.001). Discussion. Incident smoking was detrimental to graft and patient survival. Transplant programs should screen those at risk during transplant follow-up and have smoking cessation programs. C1 [Altieri, Maria; Sidawy, Anton N.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Altieri, Maria; Sidawy, Anton N.; Jindal, Rahul M.] George Washington Univ, Washington, DC USA. [Patel, Purav P.] Med Univ Lublin, Lublin, Poland. [Jindal, Tarun R.] Indiana Univ, Sch Med, Indianapolis, IN USA. [Guy, Stephen R.] Drexel Univ, Dept Surg, Div Organ Transplant, Philadelphia, PA 19104 USA. [Agodoa, Lawrence Y.] NIDDK, NIH, Bethesda, MD USA. RP Jindal, RM (reprint author), Walter Reed AMC, Dept Transplantat, Georgia Av, Washington, DC USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 28 TC 16 Z9 17 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD NOV 27 PY 2011 VL 92 IS 10 BP 1101 EP 1107 DI 10.1097/TP.0b013e3182336095 PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 845BP UT WOS:000296798100012 PM 21956202 ER PT J AU Allison, PG Horstemeyer, MF Hammi, Y Brown, HR Tucker, MT Hwang, YK AF Allison, P. G. Horstemeyer, M. F. Hammi, Y. Brown, H. R. Tucker, M. T. Hwang, Y. -K. TI Microstructure-property relations of a steel powder metal under varying temperatures, strain rates, and stress states SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Powder metallurgy; Ferrous alloys; Porous materials; Steel; Mechanical characterization ID FATIGUE; BEHAVIOR AB This study is a first to analyze the microstructure and associated plasticity and fracture characteristics under finite deformations for quantifying different applied stress state, strain rate, and temperature effects on a porous powder metal steel (FC-0205). The complexities of the inelastic deformation from the coupled plasticity-damage evolution induced stress-state differences (compression, tension, and torsion) up to 20% at just 2% strain when examining the stress-strain behavior. As far as the temperature effect, when the temperature increased, the yield stress and work hardening rate decreased as is typical in steel alloys. As the strain rate increased, the yield stress displayed an increase. The yield stress did exhibit an increase as strain rate increased for both porosity levels. However, when the strain rate increased, the work hardening did not increase as is typical in dense steel alloys. It might be that the competitions of the microbuckling and dislocation emission and interaction under compression have different rates of change, and hence the applied strain rate differences could induce these non-intuitive results. The fracture process was dominated by the stereological statistics of the porosity. The pore volume fraction (porosity) ranged from 9 to 19%, the average pore diameter was approximately 6 mu m with a maximum of 160 mu m, and the average nearest neighbor distance was approximately 10 mu m with a maximum of 60 mu m. Since the nearest neighbor distance was close to the pore size, the stress interaction between pores was almost immediate upon loading thus causing a coalescence interaction that was dominant for the tensile fracture process. Some minor cleavage planes were also observed in tension. The greater the initial porosity, the lower the elastic modulus, work hardening rate, and strain to failure. For compression, because of the large amounts of porosity, microbuckling of ligaments between pores was a key inelastic deformation mechanism along with dislocation emission and movement. For torsion, cleavage planes were very prevalent on the fracture surfaces. Published by Elsevier B.V. C1 [Allison, P. G.; Horstemeyer, M. F.; Brown, H. R.; Tucker, M. T.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA. [Hammi, Y.; Hwang, Y. -K.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. RP Allison, PG (reprint author), US ARMY ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM paul.g.allison@usace.army.mil OI Allison, Paul/0000-0002-9041-237X; Horstemeyer, Mark/0000-0003-4230-0063 FU U.S. Automotive Materials [020R22910]; Center for Advanced Vehicular Systems at Mississippi State University FX This research was funded by U.S. Automotive Materials Partnership (AMD410) contract no. FC-26-020R22910 with guidance from Howard I. Sanderow (Center for Powder Metallurgy Technology CPMT), Russell A. Chernenkoff (Metaldyne), Paulo Rosa (DaimlerChrysler), Shekhar G. Wakade (GM Powertrain), and Glen Weber (Ford Motor Company). We would also like to acknowledge the Center for Advanced Vehicular Systems at Mississippi State University for supporting this work. NR 23 TC 7 Z9 7 U1 1 U2 9 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 25 PY 2011 VL 529 BP 335 EP 344 DI 10.1016/j.msea.2011.09.037 PG 10 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 852XV UT WOS:000297391700045 ER PT J AU Hooper, JB Borodin, O Schneider, S AF Hooper, Justin B. Borodin, Oleg Schneider, Stefan TI Insight into Hydrazinium Nitrates, Azides, Dicyanamide, and 5-Azidotetrazolate Ionic Materials from Simulations and Experiments SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID FORCE-FIELD; MOLECULAR POLARIZABILITIES; LIQUIDS; DERIVATIVES; DYNAMICS; MODEL; SYSTEMS; SALTS AB A transferrable, polarizable, quantum chemistry (QC) based force field has been developed for hydrazinium (N(2)H(5)(+)), monomethylhydrazinium ((CH(3))N(2)H(4)(+)), and dimethylhydrazinium ((CH(3))(2)N(2)H(3)(+)) cations in combination with the nitrate (NO(3)), azide (N(3)(-)), dicyanamide (N(CN)(2)(-)), and 5-azidotetrazolate (CN(7)(-)) anions. Inclusion of the off-atom charge center to represent a lone pair on the hydrazinium-based cations significantly improved the electrostatic potential description around cations and led to overall a more accurate prediction of ionic crystal cell parameters in molecular dynamics (MD) simulations. Seven different ionic systems have been investigated: [N(2)H(5)][NO(3)], [(CH(3))N(2)H(4)][NO(3)], [(CH(3))(2)N(2)H(3)][NO(3)], [N(2)H(5)][CN(7)], [(CH(3))N(2)H(4)] [N(3)], [(CH(3))(2)N(2)H(3)] [N(3)], [N(2)H(5)]-[N(CN)(2)]. For all but [(CH(3))(2)N(2)H(3)][NO(3)] and [N(2)H(5)][N(CN)(2)], QC calculations of a single, gas-phase ion pair predicts spontaneous deprotonation of the cation. Crystal lattice parameters' obtained from MD simulations for these seven ionic crystals were compared with the previously published experimental data as well as the crystal structure of [N(2)H(5)] [N(CN)(2)] determined in this work from X-ray data. In general, MD simulations predicted crystal lattice vectors/angles (volumes) within a 5% (3%) absolute margin of error from experiments, with outlying volume deviations of 5-6.6% for three crystals [(CH(3))N(2)H(4)] [N(3)], [N(2)H(5)][NO(3)], and [(CH(3))N(2)H(4)] [NO(3)] with combinations of particularly small anions and/or cations. Structural comparisons between ionic materials in the liquid and crystalline states are made, including the observation of two crystalline systems where the crystalline state induces conformational changes in the methylated hydrazinium cations between the gas-phase and liquid states. Elastic constants and estimated shear and bulk moduli were extracted from MD simulations for all seven ionic crystals and correlated with the structural motifs of ion interactions in the crystals. C1 [Hooper, Justin B.; Borodin, Oleg] Wasatch Mol Inc, Salt Lake City, UT 84108 USA. [Borodin, Oleg] USA, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA. [Schneider, Stefan] USAF, Res Lab, Edwards AFB, CA 93524 USA. RP Hooper, JB (reprint author), Wasatch Mol Inc, 2141 St Marys Dr,Suite 102, Salt Lake City, UT 84108 USA. EM jbhooper@wasatchmolecular.com RI Borodin, Oleg/B-6855-2012 OI Borodin, Oleg/0000-0002-9428-5291 FU Air Force Office of Scientific Research [FA9550-09-C-0110, FA9300-06-C-0023] FX Financial support of this work was provided by the Air Force Office of Scientific Research (Mike Berman) through Contracts FA9550-09-C-0110 and FA9300-06-C-0023. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the United States Air Force. J.B.H. and O.B. thank Prof. T. D. Sewell for his helpful discussion regarding calculation of mechanical properties. Computational resources provided through the Department of Defense High Performance Computing Modernization Program (HPCMP) are highly appreciated. NR 47 TC 4 Z9 4 U1 0 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD NOV 24 PY 2011 VL 115 IS 46 BP 13578 EP 13592 DI 10.1021/jp2044064 PG 15 WC Chemistry, Physical SC Chemistry GA 847VO UT WOS:000297000800019 PM 22035180 ER PT J AU Joshi, P Shewale, V Pandey, R Shanker, V Hussain, S Karna, SP AF Joshi, Prachi Shewale, Vasundhara Pandey, Ravindra Shanker, Virendra Hussain, Saber Karna, Shashi P. TI Tryptophan-Gold Nanoparticle Interaction: A First-Principles Quantum Mechanical Study SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID PROTEINS; FLUORESCENCE; SURFACE; WATER; SIZE; DFT AB The nature of interaction between tryptophan (Trp) and gold (Au) nanoparticles is studied using first-principles density functional theory calculations and described in terms of equilibrium configurations, interaction energies, density of states, molecular orbitals, and charge density. The calculated results find the binding involving both carboxyl and indole functional groups with mixed salt-bridge and charge-solvation structure to be energetically preferred and is attributed to the stronger-than-expected pi interactions facilitated by the indole group in Trp. In the Trp-Au conjugates, modification of the molecular orbitals associated with Trp occurs because states associated with Au and the hybrid orbitals have mixed metal-molecule character. We find that the nonradiative energy transfer from excited states of Trp to hybrid states of Trp-Au may reduce intrinsic fluorescence intensity of Trp in the conjugated system. C1 [Joshi, Prachi; Shewale, Vasundhara; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Joshi, Prachi; Shanker, Virendra] Natl Phys Lab CSIR, New Delhi 110012, India. [Hussain, Saber] USAF, Res Lab HEPB, Dayton, OH 45433 USA. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Joshi, P (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM joship@nplindia.org; pandey@mtu.edu FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [611-243-2AFWP-00-104583] FX We acknowledge the support from the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (611-243-2AFWP-00-104583). P.J. and V.S. thank Saikat Mukhopadhyay, Xiaoliang Zhong, and Sankar Gowtham for their help and also acknowledge the support received during their stay at Michigan Technological University. NR 38 TC 24 Z9 24 U1 2 U2 29 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 24 PY 2011 VL 115 IS 46 BP 22818 EP 22826 DI 10.1021/jp2070437 PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 847VQ UT WOS:000297001000017 ER PT J AU Chow, BJ Small, GR Achenbach, S Al-Mallah, M Berman, D Budoff, MJ Cademartiri, F Callister, T Chang, HJ Cheng, VY Chinnaiyan, K Defago, A Dunning, AM Gomez, MJ Hadamitzky, M Hausleiter, J Karlsberg, RP Kaufmann, PA LaBounty, TM Lin, FY Maffei, E Nasir, K Pencina, MJ Raff, GL Shaw, LJ Villines, TC Min, JK AF Chow, Benjamin J. Small, Gary R. Achenbach, Stephan Al-Mallah, Mouaz Berman, Daniel Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Chang, Hyuk-Jae Cheng, Victor Y. Chinnaiyan, Kavitha Defago, Augustin Dunning, Allison M. Gomez, Millie J. Hadamitzky, Martin Hausleiter, Joerg Karlsberg, Ronald P. Kaufmann, Phillip A. LaBounty, Troy M. Lin, Fay Y. Maffei, Erica Nasir, Khurram Pencina, Micheal J. Raff, Gilbert L. Shaw, Leslee J. Villines, Todd C. Min, James K. TI Potential Benefit of Statin Therapy in Patients with Non-Obstructive Coronary Artery Disease SO CIRCULATION LA English DT Meeting Abstract DE Cardiac CT; Statins; CT angiography; Outcomes C1 [Chow, Benjamin J.; Small, Gary R.] Univ Ottawa, Inst Heart, Ottawa, ON, Canada. [Achenbach, Stephan] Univ Glessen, Glessen, Germany. [Al-Mallah, Mouaz] Wayne State Univ, Henry Ford Hosp, Detroit, MI USA. [Berman, Daniel; Cheng, Victor Y.] Cedars Sinal Med Cntr, Los Angeles, CA USA. [Budoff, Matthew J.] Los Angeles Biomed Rsch Inst, Torrance, CA USA. [Cademartiri, Filippo; Maffei, Erica] Univ Hosp Pama, Pama, Italy. [Callister, Tracy] Tennessee Heart & Vasc Inst PC, Hendersonville, TN USA. [Chang, Hyuk-Jae] Yonsel Univ Hlth Syst, Div Cardiol, Severance Cardiovasc Hosp, Seoul, South Korea. [Chinnaiyan, Kavitha] William Beaumont Hosp, Royal Oak, ON, Canada. [Defago, Augustin] Capital Cardiol Associates, Albany, NY USA. [Dunning, Allison M.] New York Presbyterian Hosp, Well Cornell Med Coll, Los Angeles, CA USA. [Gomez, Millie J.; LaBounty, Troy M.; Lin, Fay Y.] New York Presbyterian Hosp, Well Cornell Med Coll, New York, NY USA. [Hadamitzky, Martin; Hausleiter, Joerg] Deutsch Herzzentrum Munich, Munich, Germany. [Karlsberg, Ronald P.] Cardiovasc Rsch Fdn So Calif, Cedars Sinal Heart Inst, David Geffen Sch Med, Cardiovasc Med Grp So Calif,UCLA, Beverly Hills, CA USA. [Kaufmann, Phillip A.] Univ Zurich, Dept Radiol, Univ Hosp Zurich, Zurich Cntr Integrat Human Physiol ZIHP, Zurich, Switzerland. [Nasir, Khurram] Johns Hopkins Univ, Ciccarone Cntr Prevent Heart Dis, Boston, MA USA. [Pencina, Micheal J.] Harvard Clin Rsch Inst, Boston, MA USA. [Raff, Gilbert L.] William Beaumont Hosp, Royal Oak, MI USA. [Shaw, Leslee J.] Emory Univ, Atlanta, GA 30322 USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Min, James K.] Univ Ottawa, Inst Heart, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A13739 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738705275 ER PT J AU Metzger, A Rees, J McKnite, S Segal, N Matsuura, T Convertino, V Lurie, K AF Metzger, Anja Rees, Jennifer McKnite, Scott Segal, Nicolas Matsuura, Timothy Convertino, Victor Lurie, Keith TI Augmentation of Negative Intrathoracic Pressure Improves Hemodynamics Without Popping the Clot: A Randomized Study Comparing an Impedance Threshold Device vs Saline to Treat Severe Hemorrhage Through Permissive Hypotension in a Spontaneously Breathing Porcine Model SO CIRCULATION LA English DT Meeting Abstract DE Resuscitation; Emergency care C1 [Metzger, Anja; Segal, Nicolas; Matsuura, Timothy; Lurie, Keith] Univ Minnesota, Minneapolis, MN USA. [Rees, Jennifer] ACSI, St Paul, MN USA. [McKnite, Scott] Minneapolis Med Rsch Fdn, Minneapolis, MN USA. [Convertino, Victor] USA, Inst Surg Rsch, Ft Sam Houston, TX USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A142 PG 2 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738700130 ER PT J AU Min, JK Achenbach, S Al-Mallah, M Budoff, MJ Cademartiri, F Callister, TQ Chang, HJ Cheng, VY Chow, BJ Delago, AJ Dunning, AM Hadamitzky, M Leipsic, J Hausleiter, J Kaufmann, PA Lin, FY Maffei, E Raff, GL Villines, TC Shaw, LJ Berman, DS AF Min, James K. Achenbach, Stephan Al-Mallah, Mouaz Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk J. Cheng, Victor Y. Chow, Benjamin J. Delago, Augustin J. Dunning, Allison M. Hadamitzky, Martin Leipsic, Jonathon Hausleiter, Joerg Kaufmann, Philipp A. Lin, Fay Y. Maffei, Erica Raff, Gilbert L. Villines, Todd C. Shaw, Leslee J. Berman, Daniel S. TI Mortality Risk and Therapeutic Benefit of Coronary Revascularization versus Medical Therapy in 15,223 Patients Without Known Coronary Artery Disease Undergoing Coronary CT Angiography: Results from the CONFIRM Registry (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter Registry) SO CIRCULATION LA English DT Meeting Abstract DE Cardiac CT; Coronary artery disease; Noninvasive cardiac imaging; Cardiovascular imaging; International C1 [Min, James K.; Cheng, Victor Y.; Berman, Daniel S.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Achenbach, Stephan] Univ Giessen, Giessen, Germany. [Al-Mallah, Mouaz] Wayne State Univ, Henry Ford Hosp, Detroit, MI USA. [Budoff, Matthew J.] Los Angeles Biomed Rsch Inst, Torrance, CA USA. [Cademartiri, Filippo; Maffei, Erica] Univ Hosp Parma, Parma, Italy. [Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA. [Chang, Hyuk J.] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Seoul, South Korea. [Chow, Benjamin J.] Univ Ottawa, Inst Heart, Ottawa, ON, Canada. [Delago, Augustin J.] Capital Cardiol Associates, Albany, NY USA. [Dunning, Allison M.; Lin, Fay Y.] New York Presbyterian Hosp, Weill Cornell Med Coll, New York, NY USA. [Hadamitzky, Martin] Deutsch Herzzentrum Munich, Munich, Germany. [Leipsic, Jonathon] St Pauls Hosp, Vancouver, BC V6Z 1Y6, Canada. [Leipsic, Jonathon] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada. [Hausleiter, Joerg] Deutsch Herzzentrum Monchen, Munich, Germany. [Kaufmann, Philipp A.] Univ Zurich, Zurich, Switzerland. [Raff, Gilbert L.] William Beaumont Hosp, Royal Oak, MI USA. [Villines, Todd C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Shaw, Leslee J.] Emory Univ, Atlanta, GA 30322 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 SU S MA A15846 PG 3 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 884WE UT WOS:000299738707208 ER PT J AU Batchinsky, A Baker, W Isbell, C Necsoiu, C Walker, K Marczyk, J Salinas, J Cancio, L AF Batchinsky, Andriy Baker, William Isbell, Claire Necsoiu, Corina Walker, Kerfoot Marczyk, Jacek Salinas, Jose Cancio, Leopoldo TI Real-time Calculation of System-level Complexity During Trauma/Hemorrhage: Can We Do It? SO CIRCULATION LA English DT Meeting Abstract CT American-Heart-Association Scientific Sessions on Resuscitation Science Symposium CY NOV 12-15, 2011 CL Orlando, FL SP Amer Heart Assoc C1 [Batchinsky, Andriy; Baker, William; Isbell, Claire; Necsoiu, Corina; Walker, Kerfoot; Salinas, Jose; Cancio, Leopoldo] USA, Inst Surg Rsch, Ft Sam Houston, TX USA. [Marczyk, Jacek] Ontonix Srl, Como, Italy. RI Necsoiu, Corina/A-6255-2013 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD NOV 22 PY 2011 VL 124 IS 21 BP 2374 EP 2374 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 852BR UT WOS:000297320900051 ER PT J AU Bhattacharyya, D Senecal, K Marek, P Senecal, A Gleason, KK AF Bhattacharyya, Dhiman Senecal, Kris Marek, Patrick Senecal, Andre Gleason, Karen K. TI High Surface Area Flexible Chemiresistive Biosensor by Oxidative Chemical Vapor Deposition SO ADVANCED FUNCTIONAL MATERIALS LA English DT Article ID PHASE POLYMERIZATION; POLY(3,4-ETHYLENEDIOXYTHIOPHENE) FILMS; CONDUCTING COPOLYMER; AVIDIN BINDING; THIN-FILMS; SENSOR; POLYPYRROLE; FABRICATION; NANOFIBERS; IMMOBILIZATION AB Fabrication of a chemiresistive biosensor for detection of biomolecules is demonstrated on a high surface area, flexible electro-spun nylon fiber mat. For the first time, the OH functionalized conducting copolymer of 3,4-ethylenedioxythiophene (EDOT) and 3-thiopheneethanol (3-TE) is synthesized and conformally deposited on the electro-spun mats by oxidative chemical vapor deposition (oCVD). The free OH functional groups of the copolymer are available for immobilization of analyte specific biomolecules. Here, avidin and biotin molecules are employed as the analyte-specific molecule and analyte respectively for their high specificity to each other. The sensitivities of avidin immobilized conducting copolymer on electro-spun mats are tested against micro-molar to nano-molar concentrations of biotin in aqueous solutions. Application of electro-spun fiber mat in this case enhances the sensor response 6 times when compared to a flat substrate and also significantly lowers the response time. In addition to the experimental studies, current work also includes modeling of the kinetics of the change of response for the biotin-avidin interactions as a function of time. Most importantly, this fabrication technique promises an extremely sensitive and field deployable method for the detection of other biomolecules, for example, food pathogens. C1 [Bhattacharyya, Dhiman; Gleason, Karen K.] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. [Senecal, Kris] USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. [Marek, Patrick; Senecal, Andre] USA, Food Safety Def Team, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. RP Bhattacharyya, D (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA. EM kkg@mit.edu RI Senecal, Kris/F-3000-2013; Gleason, Karen/G-1471-2013 OI Gleason, Karen/0000-0001-6127-1056 FU U.S. Army through the Institute for Soldier Nanotechnologies, U.S. Army Research Office [DAAD-19-02-D-0002] FX This research was supported by the U.S. Army through the Institute for Soldier Nanotechnologies under Contract DAAD-19-02-D-0002 with the U.S. Army Research Office. The content does not necessarily reflect the position of the Government, and no official endorsement should be inferred. X-ray photoelectron spectroscopy experiments were carried out using the facilities at Cornell Center For Materials Research at Cornell University, Ithaca, NY. NR 41 TC 17 Z9 18 U1 1 U2 55 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1616-301X J9 ADV FUNCT MATER JI Adv. Funct. Mater. PD NOV 22 PY 2011 VL 21 IS 22 BP 4328 EP 4337 DI 10.1002/adfm.201101071 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 849AV UT WOS:000297097900016 ER PT J AU Lee, SY Forestiere, C Pasquale, AJ Trevino, J Walsh, G Galli, P Romagnoli, M Dal Negro, L AF Lee, Sylvanus Y. Forestiere, Carlo Pasquale, Alyssa J. Trevino, Jacob Walsh, Gary Galli, Paola Romagnoli, Marco Dal Negro, Luca TI Plasmon-enhanced structural coloration of metal films with isotropic Pinwheel nanoparticle arrays SO OPTICS EXPRESS LA English DT Article ID PHOTONIC STRUCTURES; SCATTERING; LIGHT; BEETLES; SCALE; BLUE AB We experimentally demonstrate angle-insensitive (i.e., isotropic) coloration of nanostructured metal surfaces by engineered light scattering from homogenized Pinwheel aperiodic arrays of gold nanoparticles deposited on gold substrates. In sharp contrast to the colorimetric responses of periodically nanopatterned surfaces, which strongly depend on the observation angle, Pinwheel nanoparticle arrays give rise to intense and isotropic structural coloration enhanced by plasmonic resonance. Pinwheel nanoparticle arrays with isotropic Fourier space were fabricated on a gold thin film and investigated using dark-field scattering and angle-resolved reflectivity measurements. Isotropic green coloration of metal films was demonstrated on Pinwheel patterns, with greatly reduced angular sensitivity and enhanced spatial uniformity of coloration compared to both periodic and random arrays. These findings, which are supported by coupled-dipole numerical simulations of differential scattering cross sections and radiation diagrams, could advance plasmonic applications to display, optical tagging and colorimetric sensing technologies. (C) 2011 Optical Society of America C1 [Lee, Sylvanus Y.; Forestiere, Carlo; Pasquale, Alyssa J.; Trevino, Jacob; Walsh, Gary; Dal Negro, Luca] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Lee, Sylvanus Y.; Forestiere, Carlo; Pasquale, Alyssa J.; Trevino, Jacob; Walsh, Gary; Dal Negro, Luca] Boston Univ, Photon Ctr, Boston, MA 02215 USA. [Lee, Sylvanus Y.] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA. [Trevino, Jacob; Dal Negro, Luca] Div Mat Sci & Engn, Boston, MA 02215 USA. [Walsh, Gary] USA, NSRDEC, Nano Mat Sci Team, Natick, MA 01760 USA. [Galli, Paola; Romagnoli, Marco] PhotonIC Corp, Culver City, CA 90230 USA. RP Lee, SY (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. EM dalnegro@bu.edu RI Forestiere, Carlo/A-7986-2013; Forestiere, Carlo/L-7754-2015; OI Forestiere, Carlo/0000-0003-2849-2513; Trevino, Jacob/0000-0002-7656-4107 FU Air Force program "Deterministic Aperiodic Structures for On-chip Nanophotonic and Nanoplasmonic Device Applications" [FA9550-10-1-0019]; project "Engineering structural colors in metal films"; APIC Corporation; PhotonIC Corporation FX The work was partially supported by the Air Force program "Deterministic Aperiodic Structures for On-chip Nanophotonic and Nanoplasmonic Device Applications" under Award FA9550-10-1-0019, and by the project "Engineering structural colors in metal films" sponsored by APIC Corporation and PhotonIC Corporation. PG is currently a PhotonIC consultant. This document has been approved for public release. NSRDEC PAO # U11-630. NR 32 TC 12 Z9 13 U1 1 U2 25 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD NOV 21 PY 2011 VL 19 IS 24 BP 23818 EP 23830 DI 10.1364/OE.19.023818 PG 13 WC Optics SC Optics GA 865PE UT WOS:000298322000020 PM 22109407 ER PT J AU Riley, MC Lee, JE Lesho, E Kirkup, BC AF Riley, Matthew C. Lee, James Eric Lesho, Emil Kirkup, Benjamin C., Jr. TI Optically Mapping Multiple Bacterial Genomes Simultaneously in a Single Run SO PLOS ONE LA English DT Article AB Optical mapping of bacterial chromosomes provides an unambiguous low-resolution sequence scaffold of the entire chromosome. In comparison to some techniques, such as pulse field gel electrophoresis, cost and throughput limit the application of this technique outside of genome finishing. We have demonstrated the production of multiple bacterial maps using a single set of consumables; this significantly reduces the time and expense of map production. C1 [Riley, Matthew C.; Lee, James Eric; Lesho, Emil; Kirkup, Benjamin C., Jr.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Riley, Matthew C.; Lesho, Emil; Kirkup, Benjamin C., Jr.] USA, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA. [Lesho, Emil; Kirkup, Benjamin C., Jr.] Uniformed Serv Univ Hlth Sci, Silver Spring, MD USA. RP Riley, MC (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM bckirkup@post.harvard.edu RI Kirkup, Benjamin/C-3610-2009 OI Kirkup, Benjamin/0000-0002-8722-6218 FU Department of Defense; Division of Bacterial and Rickettsial Diseases FX This research was funded entirely by the Department of Defense. No current external funding sources for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; We acknowledge the assistance of the OpGen technical support staff, the support of our respective departments and the Division of Bacterial and Rickettsial Diseases. Disclaimer: The findings and opinions expressed herein belong to the authors and do not necessarily reflect the official views of the WRAIR, the U.S. Army or the Department of Defense. NR 4 TC 7 Z9 7 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 21 PY 2011 VL 6 IS 11 AR e27085 DI 10.1371/journal.pone.0027085 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 858IO UT WOS:000297789900009 PM 22132087 ER PT J AU Densmore, JM Homan, BE Biss, MM McNesby, KL AF Densmore, John M. Homan, Barrie E. Biss, Matthew M. McNesby, Kevin L. TI High-speed two-camera imaging pyrometer for mapping fireball temperatures SO APPLIED OPTICS LA English DT Article AB A high-speed imaging pyrometer was developed to investigate the behavior of flames and explosive events. The instrument consists of two monochrome high-speed Phantom v7.3 m cameras made by Vision Research Inc. arranged so that one lens assembly collects light for both cameras. The cameras are filtered at 700 or 900 nm with a 10 nm bandpass. The high irradiance produced by blackbody emission combined with variable shutter time and f-stop produces properly exposed images. The wavelengths were chosen with the expected temperatures in mind, and also to avoid any molecular or atomic gas phase emission. Temperatures measured using this pyrometer of exploded TNT charges are presented. C1 [Densmore, John M.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. [Homan, Barrie E.; Biss, Matthew M.; McNesby, Kevin L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Densmore, JM (reprint author), Lawrence Livermore Natl Lab, Livermore, CA 94550 USA. EM densmore3@llnl.gov RI Densmore, John/G-1228-2011; OI Densmore, John/0000-0003-2388-1413; Biss, Matthew/0000-0003-3780-6393 FU U.S. Army Research Laboratory; Department of Defense (DoD); Defense Threat Reduction Agency (DTRA) FX This research was supported in part by an appointment to the U.S. Army Research Laboratory Postdoctoral Fellowship Program administered by the Oak Ridge Associated Universities through a contract with the U.S. Army Research Laboratory. This work was also supported in part by the Strategic Environmental Research and Development Program (SERDP) of the Department of Defense (DoD) and the Defense Threat Reduction Agency (DTRA). NR 20 TC 6 Z9 6 U1 1 U2 19 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 20 PY 2011 VL 50 IS 33 BP 6267 EP 6271 DI 10.1364/AO.50.006267 PG 5 WC Optics SC Optics GA 852CL UT WOS:000297324300017 PM 22108886 ER PT J AU Weiss, BM Hurst, F Agodoa, L Abbott, KC AF Weiss, Brendan M. Hurst, Frank Agodoa, Lawrence Abbott, Kevin C. TI Outcomes of Myeloma Patients on Hemodialysis in the Era of Novel Therapies: An Analysis of the US Renal Data System SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Weiss, Brendan M.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Hurst, Frank; Abbott, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Agodoa, Lawrence] NIDDK, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 787 EP 788 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597102398 ER PT J AU Weiss, BM Hebreo, J Cordaro, D Roschewski, MJ Abbott, KC Olson, SW AF Weiss, Brendan M. Hebreo, Joseph Cordaro, Daniel Roschewski, Mark J. Abbott, Kevin C. Olson, Stephen W. TI Monoclonal Gammopathy of Undetermined Significance (MGUS) Precedes the Diagnosis of AL Amyloidosis by up to 14 Years SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Weiss, Brendan M.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA. [Hebreo, Joseph] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Roschewski, Mark J.] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 797 EP 797 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597102422 ER PT J AU Mora, AG Pidcoke, HF Valdez-Delgado, KK Fedyk, CG Reddy, HL Goodrich, R Cap, AP AF Mora, Alejandra G. Pidcoke, Heather F. Valdez-Delgado, Krystal K. Fedyk, Chriselda G. Reddy, Heather L. Goodrich, Raymond Cap, Andrew P. TI Pathogen Reduction Treatment of Whole Blood Inhibits Clot Lysis and Thrombin Generation Is Preserved to 14 Days by Storage At 4 degrees C SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Mora, Alejandra G.; Valdez-Delgado, Krystal K.; Fedyk, Chriselda G.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Pidcoke, Heather F.] USA, Inst Surg Res, San Antonio, TX USA. [Reddy, Heather L.; Goodrich, Raymond] CaridianBCT, Biotechnol, Lakewood, TX USA. [Cap, Andrew P.] USA, Inst Surg Res, Hollywood Pk, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 986 EP 987 PG 2 WC Hematology SC Hematology GA 882XL UT WOS:000299597103139 ER PT J AU Roschewski, M Weniger, MA Liu, DL Lindenberg, M Pittaluga, S Kurdziel, K Dunleavy, K Wilson, WH Wiestner, A AF Roschewski, Mark Weniger, Marc A. Liu, Delong Lindenberg, Maria Pittaluga, Stefania Kurdziel, Karen Dunleavy, Kieron Wilson, Wyndham H. Wiestner, Adrian TI FDG-PET SUV Correlates with Expression of Genes Reflecting Proliferation, Metabolism, and Oncogene Activity in Mantle Cell Lymphoma (MCL) SO BLOOD LA English DT Meeting Abstract CT 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis CY DEC 10-13, 2011 CL San Diego, CA SP Amer Soc Hematol (ASH) C1 [Roschewski, Mark] Walter Reed Army Med Ctr, Dept Hematol Oncol, Washington, DC 20307 USA. [Liu, Delong; Wiestner, Adrian] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA. [Pittaluga, Stefania] NCI, Pathol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Wilson, Wyndham H.] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER SOC HEMATOLOGY PI WASHINGTON PA 1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA SN 0006-4971 J9 BLOOD JI Blood PD NOV 18 PY 2011 VL 118 IS 21 BP 1569 EP 1569 PG 1 WC Hematology SC Hematology GA 882XL UT WOS:000299597105398 ER PT J AU Frey, KE Perovich, DK Light, B AF Frey, Karen E. Perovich, Donald K. Light, Bonnie TI The spatial distribution of solar radiation under a melting Arctic sea ice cover SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID ALBEDO; EVOLUTION; SURFACE; EXTENT; CLOUD AB The sea ice cover of the Chukchi and Beaufort Seas is currently undergoing a fundamental shift from multiyear ice to first-year ice. Field observations of sea ice physical and optical properties were collected in this region during June-July 2010, revealing unexpectedly complex spatial distributions of solar radiation under the melt-season ice cover. Based on our optical measurements of first-year ice, we found the under-ice light field in the upper ocean to be spatially heterogeneous and dependent on wavelength, ice thickness, and the areal and geometric distribution of melt ponded and bare ice surfaces. Much of the observed complexity in radiation fields arose because the transmission of light through ponded ice was generally an order of magnitude greater than through bare, unponded ice. Furthermore, while many sites exhibited a consistent, exponential decay in light transmission through both ponded and bare ice surfaces, light transmission under bare ice was also observed to increase with depth (reaching maximum values similar to 5-10 m below the bottom of the ice). A simple geometric model shows these transmission peaks are a result of scattering in the ice and the interspersion of bare and ponded sea ice surfaces. These new observations of complex radiation fields beneath melt-season first-year sea ice have significant implications for biological production, biogeochemical processes, and the heat balance of sea ice and under-ice ocean waters and should be carefully considered when modeling these sea ice-related phenomena. Citation: Frey, K. E., D. K. Perovich, and B. Light (2011), The spatial distribution of solar radiation under a melting Arctic sea ice cover, Geophys. Res. Lett., 38, L22501, doi:10.1029/2011GL049421. C1 [Frey, Karen E.] Clark Univ, Grad Sch Geog, Worcester, MA 01610 USA. [Perovich, Donald K.] Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. [Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Light, Bonnie] Univ Washington, Polar Sci Ctr, Seattle, WA 98105 USA. RP Frey, KE (reprint author), Clark Univ, Grad Sch Geog, Worcester, MA 01610 USA. EM kfrey@clarku.edu FU NASA [NNX10AH71G, NNH10A017IE]; USCGC Healy FX This research was part of the NASA Impacts of Climate change on the Ecosystems and Chemistry of the Arctic Pacific Environment (ICESCAPE) project with support from the NASA Cryospheric Sciences Program (Grant #NNX10AH71G to K. Frey and Grant #NNH10A017IE to D. Perovich and B. Light) and the NASA Ocean Biology and Biogeochemistry Program. The field component of this research would not have been possible without the tremendous support from the commanding officer, marine science technicians, crew, and officers of USCGC Healy on the HLY1001 mission to the Chukchi Sea in June-July 2010. We also thank Lee Brittle, Ruzica Dadic, Christopher Polashenski, Luke Trusel, and Christie Wood for their support with field measurements. Lastly, we thank two anonymous reviewers for their constructive comments and suggestions. NR 29 TC 58 Z9 60 U1 4 U2 38 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 EI 1944-8007 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD NOV 18 PY 2011 VL 38 AR L22501 DI 10.1029/2011GL049421 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 851HH UT WOS:000297258500003 ER PT J AU Permenter, MG Lewis, JA Jackson, DA AF Permenter, Matthew G. Lewis, John A. Jackson, David A. TI Exposure to Nickel, Chromium, or Cadmium Causes Distinct Changes in the Gene Expression Patterns of a Rat Liver Derived Cell Line SO PLOS ONE LA English DT Article ID SACCHAROMYCES-CEREVISIAE; ANTIOXIDANT RESPONSE; TRANSCRIPTION FACTOR; DNA-REPAIR; MECHANISMS; METAL; PROTEIN; MODULATION; INDUCTION; TOXICITY AB Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. We identified both common and unique biological responses to exposure to the three metals. Nickel, cadmium, chromium all induced oxidative stress with both similar and unique genes and pathways responding to this stress. Although all three metals are known to be genotoxic, evidence for DNA damage in our study only exists in response to chromium. Nickel induced a hypoxic response as well as inducing genes involved in chromatin structure, perhaps by replacing iron in key proteins. Cadmium distinctly perturbed genes related to endoplasmic reticulum stress and invoked the unfolded protein response leading to apoptosis. With these studies, we have completed the first gene expression comparative analysis of nickel, cadmium, and chromium in H4-II-E-C3 cells. C1 [Permenter, Matthew G.] Excet Inc, Ft Detrick, MD USA. [Lewis, John A.; Jackson, David A.] USA, Ctr Environm Hlth Res, Ft Detrick, MD USA. RP Permenter, MG (reprint author), Excet Inc, Ft Detrick, MD USA. EM matthew.permenter@us.army.mil RI Jackson, David/E-9984-2014 FU U.S. Army Medical Research and Materiel Command FX The research was sponsored by the U.S. Army Medical Research and Materiel Command, Military Operational Medicine Research Program, and Matthew Permenter is employed by Excet, Inc. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 46 TC 26 Z9 27 U1 2 U2 15 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD NOV 16 PY 2011 VL 6 IS 11 AR e27730 DI 10.1371/journal.pone.0027730 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 855HV UT WOS:000297555400099 PM 22110744 ER PT J AU Bloomquist, L Cho, SH AF Bloomquist, Luke Cho, Sunghun TI Patient with Plaques on Lower Extremities and Systemic Symptoms SO AMERICAN FAMILY PHYSICIAN LA English DT Editorial Material ID DISEASE PRETIBIAL MYXEDEMA; GRAVES-DISEASE; SARCOIDOSIS; DERMOPATHY C1 [Bloomquist, Luke] William Beaumont Army Med Ctr, Ft Bliss, TX USA. [Cho, Sunghun] Grafenwoehr Army Hlth Clin, Grafenwoehr, Germany. RP Bloomquist, L (reprint author), William Beaumont Army Med Ctr, Ft Bliss, TX USA. EM luke.bloomquist@us.army.mil NR 14 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD NOV 15 PY 2011 VL 84 IS 10 BP 1157 EP 1159 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980AN UT WOS:000306866100008 PM 22085671 ER PT J AU Yuill, BT Gasparini, NM AF Yuill, Brendan T. Gasparini, Nicole M. TI Hydrologic controls on wash load sediment concentrations within a low-ordered, ephemeral watershed SO JOURNAL OF HYDROLOGY LA English DT Article DE Wash load; Sediment transport; Ephemeral flow; Semiarid; Fluvial geomorphology ID KINETIC-ENERGY RELATIONSHIPS; SUSPENDED SEDIMENT; FLASH FLOODS; TRANSMISSION LOSSES; NORTHERN NEGEV; OVERLAND-FLOW; HEAVY-METALS; TRANSPORT; DESERT; CATCHMENT AB This study explores the influence of rainfall and runoff production on wash load sediment transport in a low-order, ephemeral watershed in southeast Arizona. Wash load concentrations measured at the watershed outlet generally decreased throughout a runoff event and were better correlated with the rainfall intensity and the rainfall volume that fell within the 6 min (the watershed's 'time of concentration') before the sediment concentration was measured than with the runoff discharge. The difference between the rainfall volume per unit time and the runoff discharge was primarily due to infiltration and transmission losses, processes that reduce runoff volume but do not appear to affect the wash load concentration within the runoff. Infiltration and transmission losses are significant in this watershed and vary considerably in space and time but are generally described by an inverse relationship between the runoff coefficient and drainage area. Runoff coefficients vary amongst runoff events and are correlated to the peak rainfall intensity during each event. Results indicate that wash load concentrations are set by the sediment entrainment processes occurring on the hillslopes (e.g., rainsplash, Hortonian overland flow) and do not greatly fluctuate as water is routed through the watershed. This suggests that wash load concentration may be better predicted by metrics of rainfall than flow discharge in certain environments. Using rainfall as a predictor of wash load could be useful for estimating sediment fluxes in semiarid regions where flow discharge is often difficult to monitor and sediment transport concentrations can be high (i.e., >10,000 mg L(-1)). Published by Elsevier B.V. C1 [Yuill, Brendan T.] USACE ERDC, Vicksburg, MS 39180 USA. [Gasparini, Nicole M.] Tulane Univ, Dept Earth & Environm Sci, New Orleans, LA 70118 USA. RP Yuill, BT (reprint author), USACE ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM brendan.t.yuill@usace.army.mil; ngaspari@tulane.edu RI Gasparini, Nicole/H-1072-2012; Gasparini, Nicole/E-2125-2016 OI Gasparini, Nicole/0000-0002-0803-3697 NR 59 TC 5 Z9 5 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1694 J9 J HYDROL JI J. Hydrol. PD NOV 15 PY 2011 VL 410 IS 1-2 BP 73 EP 83 DI 10.1016/j.jhydrol.2011.09.011 PG 11 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 860SM UT WOS:000297968000007 ER PT J AU Rocheleau, S Kuperman, RG Dodard, SG Sarrazin, M Savard, K Paquet, L Hawari, J Checkai, RT Thiboutot, S Ampleman, G Sunahara, GI AF Rocheleau, Sylvie Kuperman, Roman G. Dodard, Sabine G. Sarrazin, Manon Savard, Kathleen Paquet, Louise Hawari, Jalal Checkai, Ronald T. Thiboutot, Sonia Ampleman, Guy Sunahara, Geoffrey I. TI Phytotoxicity and uptake of nitroglycerin in a natural sandy loam soil SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE Nitroglycerin; Plant toxicity; Soil; Uptake; Biotransformation ID ENERGETIC COMPOUNDS; EXPLOSIVES; TOXICITY; BIODEGRADATION; DENITRATION AB Nitroglycerin (NG) is widely used for the production of explosives and solid propellants, and is a soil contaminant of concern at some military training ranges. NG phytotoxicity data reported in the literature cannot be applied directly to development of ecotoxicological benchmarks for plant exposures in soil because they were determined in studies using hydroponic media, cell cultures, and transgenic plants. Toxicities of NG in the present studies were evaluated for alfalfa (Medicago sativa), barnyard grass (Echinochloa crusgalli), and ryegrass (Lolium perenne) exposed to NG in Sassafras sandy loam soil. Uptake and degradation of NG were also evaluated in ryegrass. The median effective concentration values for shoot growth ranged from 40 to 231 mg kg(-1) in studies with NG freshly amended in soil, and from 23 to 185 mg kg(-1) in studies with NG weathered-and-aged in soil. Weathering-and-aging NG in soil did not significantly affect the toxicity based on 95% confidence intervals for either seedling emergence or plant growth endpoints. Uptake studies revealed that NG was not accumulated in ryegrass but was transformed into dinitroglycerin in the soil and roots, and was subsequently translocated into the ryegrass shoots. The highest bioconcentration factors for dinitroglycerin of 685 and 40 were determined for roots and shoots, respectively. Results of these studies will improve our understanding of toxicity and bioconcentration of NG in terrestrial plants and will contribute to ecological risk assessment of NG-contaminated sites. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved. C1 [Rocheleau, Sylvie; Dodard, Sabine G.; Sarrazin, Manon; Savard, Kathleen; Paquet, Louise; Hawari, Jalal; Sunahara, Geoffrey I.] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada. [Kuperman, Roman G.; Checkai, Ronald T.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Thiboutot, Sonia; Ampleman, Guy] Def Res & Dev Canada Valcartier, Quebec City, PQ G3J 1X5, Canada. RP Sunahara, GI (reprint author), Natl Res Council Canada, Biotechnol Res Inst, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada. EM geoffrey.sunahara@cnrc-nrc.gc.ca OI Kuperman, Roman/0000-0001-5344-1633 FU U.S. Department of Defense [ER-1416] FX This research was supported by the U.S. Department of Defense through the Strategic Environmental Research and Development Program (SERDP) Project ER-1416. Soil amendment was performed by Pascal Bougie from General Dynamics Inc. Technical support was provided by Myrianne Joly, Catherine Dimacacos, and Ghalib Bardai from the Biotechnology Research Institute. This publication was assigned NRC # 53381. NR 31 TC 2 Z9 2 U1 0 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD NOV 15 PY 2011 VL 409 IS 24 BP 5284 EP 5291 DI 10.1016/j.scitotenv.2011.08.067 PG 8 WC Environmental Sciences SC Environmental Sciences & Ecology GA 853SA UT WOS:000297444800015 PM 21975007 ER PT J AU Weyrauch, T Vorontsov, MA Carhart, GW Beresnev, LA Rostov, AP Polnau, EE Liu, JJ AF Weyrauch, Thomas Vorontsov, Mikhail A. Carhart, Gary W. Beresnev, Leonid A. Rostov, Andrey P. Polnau, Ernst E. Liu, Jony Jiang TI Experimental demonstration of coherent beam combining over a 7 km propagation path SO OPTICS LETTERS LA English DT Article ID FIBER COLLIMATORS; ADAPTIVE ARRAY; PROJECTION; TURBULENCE AB We demonstrate coherent combining (phase locking) of seven laser beams emerging from an adaptive fiber-collimator array over a 7 km atmospheric propagation path using a target-in-the-loop (TIL) setting. Adaptive control of the piston and the tip and tilt wavefront phase at each fiber-collimator subaperture resulted in automatic focusing of the combined beam onto an unresolved retroreflector target (corner cube) with precompensation of quasi-static and atmospheric turbulence-induced phase aberrations. Both phase locking (piston) and tip-tilt control were performed by maximizing the target-return optical power using iterative stochastic parallel gradient descent (SPGD) techniques. The performance of TIL coherent beam combining and atmospheric mitigation was significantly increased by using an SPGD control variation that accounts for the round-trip propagation delay (delayed SPGD). (C) 2011 Optical Society of America C1 [Weyrauch, Thomas; Vorontsov, Mikhail A.; Polnau, Ernst E.] Univ Dayton, Intelligent Opt Lab, Sch Engn, Dayton, OH 45469 USA. [Carhart, Gary W.; Beresnev, Leonid A.; Liu, Jony Jiang] USA, Intelligent Opt Lab, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. [Vorontsov, Mikhail A.; Rostov, Andrey P.] Optonicus, Dayton, OH 45402 USA. RP Weyrauch, T (reprint author), Univ Dayton, Intelligent Opt Lab, Sch Engn, 300 Coll Pk, Dayton, OH 45469 USA. EM thomas.weyrauch@udayton.edu NR 11 TC 47 Z9 52 U1 2 U2 20 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD NOV 15 PY 2011 VL 36 IS 22 BP 4455 EP 4457 PG 3 WC Optics SC Optics GA 850RL UT WOS:000297215300049 PM 22089595 ER PT J AU Linkov, I Coles, JB Welle, P Bates, M Keisler, J AF Linkov, Igor Coles, John B. Welle, Paul Bates, Matthew Keisler, Jeffrey TI Anthrax Cleanup Decisions: Statistical Confidence or Confident Response SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Editorial Material C1 [Linkov, Igor; Coles, John B.; Welle, Paul; Bates, Matthew] USA, Corps Engineers, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Keisler, Jeffrey] Univ Massachusetts, Boston, MA 02125 USA. RP Linkov, I (reprint author), USA, Corps Engineers, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.linkov@usace.army.mil NR 3 TC 2 Z9 2 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD NOV 15 PY 2011 VL 45 IS 22 BP 9471 EP 9472 DI 10.1021/es203479t PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 844OI UT WOS:000296756500002 PM 22029373 ER PT J AU Xu, ZH Hao, JM Braida, W Strickland, D Li, FS Meng, XG AF Xu, Zhonghou Hao, Jumin Braida, Washington Strickland, David Li, Fasheng Meng, Xiaoguang TI Surface-Enhanced Raman Scattering Spectroscopy of Explosive 2,4-Dinitroanisole using Modified Silver Nanoparticles SO LANGMUIR LA English DT Article ID ADSORPTION; MOLECULES; CHARGE; SERS AB 2,4-Dinitroanisole (DNAN) is being used as a replacement for 2,4,6-trinitrotoluene (TNT) as a less-sensitive melt-cast medium explosive than TNT. In this paper, we studied the surface-enhanced Raman spectroscopy (SERS) analysis of DNAN using Ag nanoparticles (AgNPs) modified by L-cysteine methyl ester hydrochloride. Due to the formation of a Meisenheimer complex between DNAN and the modifier, the modified AgNPs can detect 20 mu g/L (0.2 ng) and 0.1 mg/L (1 ng) DNAN in deionized water and aged tap water, respectively. Three other chemicals (L-cysteine, N-acetyl-L-cysteine, and L-cysteine ethyl ester hydrochloride) were used as AgNPs modifiers to study the mechanism of the SERS of DNAN. It was confirmed that the amino group of L-cysteine methyl ester hydrochloride was the active group and that the methyl ester group significantly contributed to the high SEAS sensitivity of DNAN. In order to further test the mechanism of Meisenheimer complex formation, the effect of anions and cations present in natural water on the SEAS of DNAN was studied. It was found that CO(3)(2-), Cl(-), and K(+) at 100 mg/L did not negatively affect the SEAS of 10 mg/L DNAN, while SO(4)(2-), Na(+), Mg(2+), and Ca(2+) at 100 mg/L significantly quenched the SERS of 10 mg/L DNAN. The negative effect of the bivalent cations could be offset by SO(4)(2-). C1 [Xu, Zhonghou; Hao, Jumin; Braida, Washington; Meng, Xiaoguang] Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. [Strickland, David] USA, Environm Technol Div, Picatinny Arsenal, NJ 07086 USA. [Li, Fasheng] Chinese Res Inst Environm Sci, Lab Soil Pollut Control, Beijing 100012, Peoples R China. RP Meng, XG (reprint author), Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. EM xmeng@stevens.edu RI Xu, Zhonghou/L-9969-2016 OI Xu, Zhonghou/0000-0003-4021-8154 NR 29 TC 23 Z9 24 U1 2 U2 57 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD NOV 15 PY 2011 VL 27 IS 22 BP 13773 EP 13779 DI 10.1021/la202560t PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 842KM UT WOS:000296598300046 PM 21967647 ER PT J AU Mathew, A West, K Kalayanarooj, S Gibbons, RV Srikiatkhachorn, A Green, S Libraty, D Jaiswal, S Rothman, AL AF Mathew, Anuja West, Kim Kalayanarooj, Siripen Gibbons, Robert V. Srikiatkhachorn, Anon Green, Sharone Libraty, Daniel Jaiswal, Smita Rothman, Alan L. TI B-Cell Responses During Primary and Secondary Dengue Virus Infections in Humans SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID MONOCLONAL-ANTIBODIES; ENVELOPE PROTEIN; COMMON EPITOPES; DOMAIN-III; MEMORY B; VIREMIA; NONSTRUCTURAL-1; NEUTRALIZATION; GLYCOPROTEIN; IDENTIFICATION AB Low-avidity serotype-cross-reactive antibodies are hypothesized to play a key role in triggering severe disease in patients with secondary dengue virus (DENV) infection. However, there is little systematic information about the frequency, avidity, and cross-reactivity of DENV-specific B cells in individuals experiencing primary instead of secondary infection. We compared DENV-specific B-cell responses in a cohort of Thai children with primary or secondary DENV infection. B cells specific for DENV precursor membrane protein, envelope (E) protein, and nonstructural protein 1 were detectable in immune peripheral blood mononuclear cells with the highest frequencies of DENV E-specific B cells detected in patients experiencing primary DENV-1 infections. DENV E-specific B cells were highly serotype-specific after primary DENV infections, whereas most E-specific B cells in patients with secondary infection were serotype-cross-reactive and secreted antibodies with higher avidity to heterologous DENV serotypes. Our data suggest that the minor populations of serotype-cross-reactive B cells generated by primary DENV infection are preferentially expanded during secondary DENV infection. C1 [Mathew, Anuja; West, Kim; Srikiatkhachorn, Anon; Green, Sharone; Libraty, Daniel; Jaiswal, Smita; Rothman, Alan L.] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA USA. [West, Kim] Queen Sirikit Natl Inst Child Hlth, Dengue Unit, Bangkok, Thailand. [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Mathew, A (reprint author), S6-862,55 Lake Ave N, Worcester, MA 01655 USA. EM anuja.mathew@umassmed.edu FU National Institutes of Health [P01 AI34533]; US Army Military Infectious Disease Research Program FX This work was supported by the National Institutes of Health (P01 AI34533); and the US Army Military Infectious Disease Research Program. NR 36 TC 36 Z9 37 U1 0 U2 5 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV 15 PY 2011 VL 204 IS 10 BP 1514 EP 1522 DI 10.1093/infdis/jir607 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 834UU UT WOS:000295990400007 PM 21930609 ER PT J AU Sahin, A Dooley, K Cropek, DM West, AC Banta, S AF Sahin, Asli Dooley, Kevin Cropek, Donald M. West, Alan C. Banta, Scott TI A dual enzyme electrochemical assay for the detection of organophosphorus compounds using organophosphorus hydrolase and horseradish peroxidase SO SENSORS AND ACTUATORS B-CHEMICAL LA English DT Article DE Organophosphorus hydrolase (OPH); Horseradish peroxidase (HRP); Mediated electron transfer; Electrochemical biosensor; Organophosphate pesticides; Dichlofenthion ID AMPEROMETRIC MICROBIAL BIOSENSOR; FLOW-INJECTION ANALYSIS; NERVE AGENTS; CARBON NANOTUBES; PSEUDOMONAS-DIMINUTA; GRAPHITE ELECTRODE; AROMATIC-COMPOUNDS; PESTICIDES; PHENOLS; SENSOR AB Neurotoxic organophosphorus (OP) compounds are commonly used as chemical warfare agents and pesticides. Due to their high toxicity, rapid and sensitive field detection of these compounds has been an ongoing topic of interest. Biosensors made with organophosphate hydrolase enzyme (OPH) are generally designed to either amperometrically detect an electroactive leaving group produced following enzymatic cleavage, or to potenitometrically detect the pH change that occurs during cleavage. Since OPs are more likely to have phenolic leaving groups as compared to electroactive leaving groups, we have developed a new amperometric dual enzyme electrochemical assay that enables the detection of a broad class of OP compounds using the OPH enzyme combined with horseradish peroxidase (HRP). The assay has been applied to the detection of dichlofenthion, which does not have an electroactive leaving group and is not a commonly investigated OPH substrate. Using reverse phase HPLC, we have determined the Michaelis-Menten kinetic parameters of an engineered OPH enzyme to be K-M = 0.11 +/- 0.02 mM and k(cat) = 0.046 +/- 0.003 s(-1) with dichlofenthion as the substrate. Detection of the phenolic leaving group from the OPH enzyme reaction using the H RP electrode is carried out at 50 mV vs. Ag/AgCl where the noise and background are low and interferences are negligible. After optimization of the solution pH, the dual enzyme biosensor was found to have a limit of detection CLOD) of 24 mu M (7.6 ppm), and a sensitivity of 0.095 +/- 0.024 nA/mu M for dichlorofenthion. By detecting the phenolic leaving groups from the OP targets using the HRP electrode, biosensors made using this new platform have the potential to detect a broad range of important OP compounds. (C) 2011 Elsevier B.V. All rights reserved. C1 [Sahin, Asli; Dooley, Kevin; West, Alan C.; Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. [Cropek, Donald M.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Banta, S (reprint author), Columbia Univ, Dept Chem Engn, New York, NY 10027 USA. EM sbanta@columbia.edu FU U.S. Army Corps of Engineers; U.S. Army Engineering Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL) FX This research was supported by U.S. Army Corps of Engineers Applied Research program with funding from the U.S. Army Engineering Research and Development Center, Construction Engineering Research Laboratory (ERDC-CERL). The authors would also like to thank Mr. Hoang D. Lu and Dr Zengmin Li for their valuable contributions. NR 52 TC 21 Z9 23 U1 6 U2 47 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0925-4005 J9 SENSOR ACTUAT B-CHEM JI Sens. Actuator B-Chem. PD NOV 15 PY 2011 VL 158 IS 1 BP 353 EP 360 DI 10.1016/j.snb.2011.06.034 PG 8 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 828KP UT WOS:000295500200050 ER PT J AU Xu, W Xu, K Viswanathan, VV Towne, SA Hardy, JS Xiao, J Hu, DH Wang, DY Zhang, JG AF Xu, Wu Xu, Kang Viswanathan, Vilayanur V. Towne, Silas A. Hardy, John S. Xiao, Jie Hu, Dehong Wang, Deyu Zhang, Ji-Guang TI Reaction mechanisms for the limited reversibility of Li-O-2 chemistry in organic carbonate electrolytes SO JOURNAL OF POWER SOURCES LA English DT Article DE Li-O-2 chemistry; Carbonate electrolyte; Reversibility; Lithium alkylcarbonate; X-ray diffraction; Gas chromatography/mass spectroscopy ID RECHARGEABLE LITHIUM BATTERIES; NONAQUEOUS ELECTROLYTES; LI/AIR BATTERIES; OPTIMIZATION; CATALYST AB The Li-O-2 chemistry in nonaqueous liquid carbonate electrolytes and the underlying reason for its limited reversibility was systematically investigated. X-ray diffraction data showed that regardless of discharge depth lithium alkylcarbonates (lithium propylenedicarbonate (LPDC), or lithium ethylenedicarbonate (LEDC), with other related derivatives) and lithium carbonate (Li2CO3) are constantly the main discharge products, while lithium peroxide (Li2O2) or lithium oxide (Li2O) is hardly detected. These lithium alkylcarbonates are generated from the reductive decomposition of the corresponding carbonate solvents initiated by the attack of superoxide radical anions. More significantly, in situ gas chromatography/mass spectroscopy analysis revealed that Li2CO3 and Li2O cannot be oxidized even when charged to 4.6V vs. Li/Li+, while LPDC, LEDC and Li2O2 are readily oxidized, with CO2 and CO released from LPDC and LEDC and O-2 evolved from Li2O2. Therefore, the apparent reversibility of Li-O-2 chemistry in an organic carbonate-based electrolyte is actually an unsustainable process that consists of (1) the formation of lithium alkylcarbonates through the reductive decomposition of carbonate solvents during discharging and (2) the subsequent oxidation of these same alkylcarbonates during charging. Therefore, a stable electrolyte that does not lead to an irreversible by-product formation during discharging and charging is necessary for truly rechargeable Li-O-2 batteries. (C) 2011 Elsevier B.V. All rights reserved. C1 [Xu, Wu; Viswanathan, Vilayanur V.; Towne, Silas A.; Hardy, John S.; Xiao, Jie; Wang, Deyu; Zhang, Ji-Guang] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. [Xu, Kang] USA, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Hu, Dehong] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA. RP Xu, W (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA. EM wu.xu@pnl.gov; jiguang.zhang@pnl.gov RI Hu, Dehong/B-4650-2010; Deyu, Wang/J-9496-2014; Hardy, John/E-1938-2016; OI Hu, Dehong/0000-0002-3974-2963; Hardy, John/0000-0002-1699-3196; Xu, Wu/0000-0002-2685-8684 FU Pacific Northwest National Laboratory (PNNL) FX This work was supported by the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory (PNNL), a multi-program national laboratory operated by Battelle for the U.S. Department of Energy. The authors thank Drs. Jun Liu, Gordon L. Graff, and Mark E. Gross of PNNL for their support and help on the project. Dr. Shengshui Zhang of U.S. Army Research Laboratory is appreciated for his useful comments and discussions. NR 22 TC 127 Z9 130 U1 10 U2 100 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD NOV 15 PY 2011 VL 196 IS 22 BP 9631 EP 9639 DI 10.1016/j.jpowsour.2011.06.099 PG 9 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 829RQ UT WOS:000295602400071 ER PT J AU Olson, MA Chaudhury, S Lee, MS AF Olson, Mark A. Chaudhury, Sidhartha Lee, Michael S. TI Comparison Between Self-Guided Langevin Dynamics and Molecular Dynamics Simulations for Structure Refinement of Protein Loop Conformations SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE comparative protein models; protein variable regions; conformational sampling; replica-exchange methods ID MULTISCALE MODELING METHODS; HIGH-RESOLUTION REFINEMENT; REPLICA-EXCHANGE; FORCE-FIELD; STRUCTURE PREDICTION; STATISTICAL POTENTIALS; FREE-ENERGIES; OPTIMIZATION; STABILITY; SELECTION AB This article presents a comparative analysis of two replica-exchange simulation methods for the structure refinement of protein loop conformations, starting from low-resolution predictions. The methods are self-guided Langevin dynamics (SGLD) and molecular dynamics (MD) with a Nose-Hoover thermostat. We investigated a small dataset of 8- and 12-residue loops, with the shorter loops placed initially from a coarse-grained lattice model and the longer loops from an enumeration assembly method (the Loopy program). The CHARMM22 _ CMAP force field with a generalized Born implicit solvent model (molecular-surface parameterized GBSW2) was used to explore conformational space. We also assessed two empirical scoring methods to detect nativelike conformations from decoys: the all-atom distance-scaled ideal-gas reference state (DFIRE-AA) statistical potential and the Rosetta energy function. Among the eight-residue loop targets, SGLD out performed MD in all cases, with a median of 0.48 angstrom reduction in global root-mean-square deviation (RMSD) of the loop backbone coordinates from the native structure. Among the more challenging 12-residue loop targets, SGLD improved the prediction accuracy over MD by a median of 1.31 angstrom, representing a substantial improvement. The overall median RMSD for SGLD simulations of 12-residue loops was 0.91 angstrom, yielding refinement of a median 2.70 angstrom from initial loop placement. Results from DFIRE-AA and the Rosetta model applied to rescoring conformations failed to improve the overall detection calculated from the CHARMM force field. We illustrate the advantage of SGLD over the MD simulation model by presenting potential-energy landscapes for several loop predictions. Our results demonstrate that SGLD significantly outperforms traditional MD in the generation and populating of nativelike loop conformations and that the CHARMM force field performs comparably to other empirical force fields in identifying these conformations from the resulting ensembles. Published 2011 Wiley Periodicals, Inc.(+) J Comput Chem 32: 3014-3022, 2011 C1 [Olson, Mark A.; Lee, Michael S.] USA, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Chaudhury, Sidhartha] USA, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD 21702 USA. [Lee, Michael S.] USA, Computat Sci & Engn Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Olson, MA (reprint author), USA, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM molson@compbiophys.org FU US DoD Threat Reduction Agency [DTRA TMTI0004_09_BH_T]; Department of Defense Biotechnology High Performance Computing Software Applications Institute FX Contract/grant sponsor: US DoD Threat Reduction Agency; Contract/grant number: DTRA TMTI0004_09_BH_T; Contract/grant sponsor: Department of Defense Biotechnology High Performance Computing Software Applications Institute. NR 44 TC 12 Z9 12 U1 0 U2 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD NOV 15 PY 2011 VL 32 IS 14 BP 3014 EP 3022 DI 10.1002/jcc.21883 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA 823LE UT WOS:000295123000008 PM 21793008 ER PT J AU Wunderer, T Northrup, JE Yang, ZH Teepe, M Strittmatter, A Johnson, NM Rotella, P Wraback, M AF Wunderer, Thomas Northrup, John E. Yang, Zhihong Teepe, Mark Strittmatter, Andre Johnson, Noble M. Rotella, Paul Wraback, Michael TI In-well pumping of InGaN/GaN vertical-external-cavity surface-emitting lasers SO APPLIED PHYSICS LETTERS LA English DT Article AB In-well-pumped blue InGaN/GaN vertical-external-cavity surface-emitting lasers are demonstrated. The laser structures were grown on bulk GaN substrates by using metal-organic vapor phase epitaxy near atmospheric pressure. The active zone consisted of up to 20 InGaN quantum wells distributed in a resonant periodic gain configuration. High-reflectivity dielectric distributed Bragg-reflectors were used as mirrors. Laser emission with a single longitudinal mode at 440 nm was achieved by exclusively pumping the quantum wells with the 384 nm emission line of a dye-/N(2)-laser. (C) 2011 American Institute of Physics. [doi:10.1063/1.3663575] C1 [Wunderer, Thomas; Northrup, John E.; Yang, Zhihong; Teepe, Mark; Strittmatter, Andre; Johnson, Noble M.] Palo Alto Res Ctr Inc, Palo Alto, CA 94304 USA. [Rotella, Paul; Wraback, Michael] USA, Res Lab, Adelphi, MD 20783 USA. [Strittmatter, Andre] Tech Univ Berlin, Inst Festkorperphys, D-10623 Berlin, Germany. RP Wunderer, T (reprint author), Palo Alto Res Ctr Inc, 3333 Coyote Hill Rd, Palo Alto, CA 94304 USA. EM thomas.wunderer@parc.com FU U.S. Defense Threat Reduction Agency (DTRA) under U.S. Army [W911NF-10-2-0008] FX The authors are pleased to acknowledge helpful discussions with M. Kneissl, Technische Universitat Berlin, Germany. The work was supported by the U.S. Defense Threat Reduction Agency (DTRA) under U.S. Army Cooperative Agreement No. W911NF-10-2-0008. NR 8 TC 15 Z9 15 U1 3 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 14 PY 2011 VL 99 IS 20 AR 201109 DI 10.1063/1.3663575 PG 3 WC Physics, Applied SC Physics GA 858HL UT WOS:000297786500009 ER PT J AU Chen, Y Nasrabadi, NM Tran, TD AF Chen, Yi Nasrabadi, Nasser M. Tran, Trac D. TI Effects of linear projections on the performance of target detection and classification in hyperspectral imagery SO JOURNAL OF APPLIED REMOTE SENSING LA English DT Article DE hyperspectral imagery; target detection; classification; dimensionality reduction; linear projection ID NONLINEAR DIMENSIONALITY REDUCTION; MATCHED-FILTER; SUPPORT AB We explore the use of several linear dimensionality reduction techniques that can be easily integrated into the hyperspectral imaging sensor. We investigate their effect on the performance of classical target detection and classification techniques for hyperspectral images. Specifically, each N-dimensional spectral pixel is embedded to an M- dimensional measurement space with M << N by a linear transformation (e.g., random measurement matrices, uniform downsampling, principal component analysis). The detectors/classifiers are then applied to the M- dimensional measurement vectors and their performances are compared to those obtained from the entire N-dimensional spectrum. Through extensive experiments on several hyperspectral imagery data sets, we demonstrate that only a small amount of measurements are necessary to achieve comparable performance to that obtained by exploiting the full N-dimensional pixels. C (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3659894] C1 [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Chen, Y (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, 3400 N Charles St, Baltimore, MD 21218 USA. FU ARO [58110-MA-II]; NSF [CCF-0728893] FX This paper is partially supported by ARO Grant No. 58110-MA-II and NSF Grant No. CCF-0728893. NR 36 TC 3 Z9 3 U1 0 U2 9 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1931-3195 J9 J APPL REMOTE SENS JI J. Appl. Remote Sens. PD NOV 14 PY 2011 VL 5 AR 053563 DI 10.1117/1.3659894 PG 25 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 850AC UT WOS:000297165800002 ER PT J AU Osman, KT Wan, M Matthaeus, WH Breech, B Oughton, S AF Osman, K. T. Wan, M. Matthaeus, W. H. Breech, B. Oughton, S. TI DIRECTIONAL ALIGNMENT AND NON-GAUSSIAN STATISTICS IN SOLAR WIND TURBULENCE SO ASTROPHYSICAL JOURNAL LA English DT Article DE magnetohydrodynamics (MHD); plasmas; solar wind; turbulence ID INDUCED ELECTRIC-FIELD; RELAXATION PROCESSES; ALFVEN WAVES; MAGNETOHYDRODYNAMICS; EVOLUTION AB The magnetic and velocity field fluctuations in magnetohydrodynamic turbulence can be characterized by their directional alignment and induced electric field. These manifest as coherent spatial correlations which are measures of Alfvenicity and turbulence cascade strength, respectively. Solar wind observations and direct numerical simulations find that these distinctive correlations, caused by rapid relaxation processes that act to suppress nonlinearity, occur in localized spatial patches. This cellularization of magnetofluid turbulence is inconsistent with a superposition of Gaussian fields and could be related to spatial intermittency or other non-Gaussian statistics. C1 [Osman, K. T.; Wan, M.; Matthaeus, W. H.] Univ Delaware, Dept Phys & Astron, Bartol Res Inst, Newark, DE 19716 USA. [Breech, B.] USA, Res Lab, Adelphi, MD USA. [Oughton, S.] Univ Waikato, Dept Math, Hamilton, New Zealand. RP Osman, KT (reprint author), Univ Delaware, Dept Phys & Astron, Bartol Res Inst, Newark, DE 19716 USA. EM kto@udel.edu RI Wan, Minping/A-1344-2011; Oughton, Sean/A-3380-2012 OI Oughton, Sean/0000-0002-2814-7288 FU NSF [AGS-1063439]; NSF SHINE [ATM-0752135]; NASA [NNX08AI47G] FX This research is supported in part by the NSF Solar Terrestrial Program under grant AGS-1063439 and the NSF SHINE Program ATM-0752135, and by NASA under the Heliophysics Theory Program grant NNX08AI47G. NR 26 TC 10 Z9 10 U1 0 U2 5 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0004-637X J9 ASTROPHYS J JI Astrophys. J. PD NOV 10 PY 2011 VL 741 IS 2 AR 75 DI 10.1088/0004-637X/741/2/75 PG 5 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA 844TT UT WOS:000296771500008 ER PT J AU Schwenk, R Lumsden, JM Rein, LE Juompan, L Kester, KE Heppner, DG Krzych, U AF Schwenk, Robert Lumsden, Joanne M. Rein, Lisa E. Juompan, Laure Kester, Kent E. Heppner, D. Gray Krzych, Urszula TI Immunization with the RTS,S/AS malaria vaccine induces IFN-gamma (+)CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge SO VACCINE LA English DT Article DE RTS,S; CD4 T cells; Specificities ID PLASMODIUM-FALCIPARUM; DOUBLE-BLIND; SPOROZOITE; EPITOPE; TRIAL; PROTECTION; EFFICACY; DOMAINS; ANTIGEN; SAFETY AB In a Phase 2a trial of the RTS,S/AS vaccine, we described significant association between protection against infection and vaccine-induced CD4 T cells. To determine whether processing of the circumsporozoite protein as a component of the RTS,S particulate antigen yields the same HLA-DR-restricted epitopes as those recognized by CD4 T cells from donors immunized by exposure to attenuated or infectious sporozoites we mapped the specificities of the RTS,S primed CD4 T cells by measuring IFN-gamma cultured Elispot responses to pairs of overlapping 15 a.a. peptides that span the protein's C-terminus. Peptide pairs representing the previously described TH2R, T* and CS.T3 epitopes, were immunoprevalent and immunodominant. There was no response to the peptides corresponding to the human thrombospondin homology region. Responses to the CD4 T cell epitopes were restricted by multiple HLA-DR haplotypes. Of note, HLA-DR4 and HLA-DR11 restricted epitopes in the T* region and in the location on the CS protein defined by peptide pair 4, respectively. We conclude that processing of the CS protein derived from the RTS,S antigen leads to the generation of HLA-DR-restricted epitopes that are similar to those identified previously using CD4 T cells from subjects immunized with and protected by attenuated sporozoites or exposed to infectious sporozoites. This may in part account for the protective efficacy of the RTS,S/AS vaccine. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Schwenk, Robert; Lumsden, Joanne M.; Rein, Lisa E.; Juompan, Laure; Kester, Kent E.; Heppner, D. Gray; Krzych, Urszula] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Schwenk, R (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM robert.schwenk@amedd.army.mil FU United States Army Medical Materiel Development Activity; Military Infectious Diseases Research Program (Fort Detrick, Maryland); GlaxoSmithKline Biologicals (Rixensart, Belgium) FX The authors gratefully acknowledge Joe Cohen, Yannick Vanloubbeeck, and Philippe Moris for their critical review of the manuscript. This work was supported by the United States Army Medical Materiel Development Activity and the Military Infectious Diseases Research Program (Fort Detrick, Maryland) and by GlaxoSmithKline Biologicals (Rixensart, Belgium). NR 22 TC 5 Z9 5 U1 0 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 8 PY 2011 VL 29 IS 48 BP 8847 EP 8854 DI 10.1016/j.vaccine.2011.09.098 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 855YC UT WOS:000297601200011 PM 21983360 ER PT J AU Sablon, K Sergeev, A Vagidov, N Antipov, A Little, J Mitin, V AF Sablon, Kimberly Sergeev, Andrei Vagidov, Nizami Antipov, Andrei Little, John Mitin, Vladimir TI Effective harvesting, detection, and conversion of IR radiation due to quantum dots with built-in charge SO NANOSCALE RESEARCH LETTERS LA English DT Article DE quantum dot; infrared photodetector; solar cell; photoresponse; doping; potential barrier; capture processes ID SOLAR-CELLS; PHOTODETECTOR; EFFICIENCY AB We analyze the effect of doping on photoelectron kinetics in quantum dot [QD] structures and find two strong effects of the built-in-dot charge. First, the built-in-dot charge enhances the infrared [IR] transitions in QD structures. This effect significantly increases electron coupling to IR radiation and improves harvesting of the IR power in QD solar cells. Second, the built-in charge creates potential barriers around dots, and these barriers strongly suppress capture processes for photocarriers of the same sign as the built-in-dot charge. The second effect exponentially increases the photoelectron lifetime in unipolar devices, such as IR photodetectors. In bipolar devices, such as solar cells, the solar radiation creates the built-in-dot charge that equates the electron and hole capture rates. By providing additional charge to QDs, the appropriate doping can significantly suppress the capture and recombination processes via QDs. These improvements of IR absorption and photocarrier kinetics radically increase the responsivity of IR photodetectors and photovoltaic efficiency of QD solar cells. C1 [Sergeev, Andrei; Vagidov, Nizami; Antipov, Andrei; Mitin, Vladimir] SUNY Buffalo, Buffalo, NY 14260 USA. [Sablon, Kimberly; Little, John] USA, Res Lab, Adelphi, MD 20783 USA. RP Mitin, V (reprint author), SUNY Buffalo, Buffalo, NY 14260 USA. EM vmitin@buffalo.edu FU Air Force Office of Scientific Research FX The work is supported by the Air Force Office of Scientific Research. NR 21 TC 13 Z9 13 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1931-7573 J9 NANOSCALE RES LETT JI Nanoscale Res. Lett. PD NOV 7 PY 2011 VL 6 BP 1 EP 13 AR 584 DI 10.1186/1556-276X-6-584 PG 13 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Science & Technology - Other Topics; Materials Science; Physics GA 874YX UT WOS:000298996000001 PM 22060635 ER PT J AU Feller, AJ McKenzie, R Taylor, DN Woods, CC Grahek, SL Islam, D Venkatesan, MM Hale, TL Bourgeois, AL AF Feller, Andrea J. McKenzie, Robin Taylor, David N. Woods, Colleen C. Grahek, Shannon L. Islam, Dilara Venkatesan, Malabi M. Hale, Thomas L. Bourgeois, August L. TI Comparative evaluation of the antibody in lymphocyte supernatant (ALS) and enzyme-linked immunospot (ELISPOT) assays for measuring mucosal immune responses to Shigella antigens SO VACCINE LA English DT Article DE Shigella; Mucosal immune response; ELISPOT; ALS ID ENTEROTOXIGENIC ESCHERICHIA-COLI; VACCINE; IMMUNOGENICITY; SAFETY; VOLUNTEERS; BURDEN; CELLS AB Accurately assessing mucosal immune responses to candidate vaccines remains a technical challenge. ELISPOT is widely used as a surrogate of mucosal immune response by directly enumerating circulating antibody secreting cells (ASCs), while antibody in lymphocyte supernatant (ALS) titers the total amount of antibody secreted by ASC ex vivo using ELISA. ALS is more practical than ELISPOT because the ASC supernatant is frozen for ELISA that can be conducted at any time, with any antigen, and in any laboratory. We compared IgA and IgG responses to serotype-specific Shigella LPS using ELISPOT and ALS in subjects following vaccination or infection with Shigella. ALS results correlated well with ELISPOT results, and the ALS method was both sensitive and specific for the detection of antibody responses against Shigella LPS. Based on these observations, the ALS assay is a practical and flexible alternative to ELISPOT for measuring mucosal IgA responses to Shigella LPS antigen. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Feller, Andrea J.; McKenzie, Robin; Taylor, David N.; Woods, Colleen C.; Grahek, Shannon L.; Bourgeois, August L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Immunizat Res Global Dis Epidemiol & Control, Baltimore, MD 21205 USA. [McKenzie, Robin] Johns Hopkins Univ, Johns Hopkins Bayview Med Ctr, Div Infect Dis, Baltimore, MD USA. [Islam, Dilara] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Venkatesan, Malabi M.; Hale, Thomas L.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Feller, AJ (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Immunizat Res Global Dis Epidemiol & Control, 615 N Wolfe St, Baltimore, MD 21205 USA. EM afeller@jhsph.edu FU USAMRMC [DAMD17-01-D-0011]; Johns Hopkins University School of Medicine GCRC from the National Center for Research Resources [M01-RR00052]; Salix Pharmaceuticals; DHHS, NIH, National Eye Institute [EY07127] FX This work was supported by the USAMRMC grant # DAMD17-01-D-0011, by Johns Hopkins University School of Medicine GCRC grant # M01-RR00052 from the National Center for Research Resources, and by Salix Pharmaceuticals. A. Feller is supported by the DHHS, NIH, National Eye Institute Training Grant Number EY07127, Clinical Trials Training Program in Vision Research. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the WRAIR/NMRC, the Department of the Army or the Department of Defense. The authors would like to thank the staff of the Johns Hopkins University Center for Immunization Research and the WRAIR, as well as Dr. David Sack, for their help in preparing this manuscript. NR 16 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD NOV 3 PY 2011 VL 29 IS 47 BP 8487 EP 8489 DI 10.1016/j.vaccine.2011.09.030 PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 848GA UT WOS:000297037400002 PM 21939714 ER PT J AU Morris, MJ Zacher, LL AF Morris, Michael J. Zacher, Lisa L. TI Constrictive Bronchiolitis in Soldiers SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 [Morris, Michael J.; Zacher, Lisa L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Morris, MJ (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM michael.morris@amedd.army.mil NR 4 TC 5 Z9 5 U1 0 U2 0 PU MASSACHUSETTS MEDICAL SOC PI WALTHAM PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 3 PY 2011 VL 365 IS 18 BP 1743 EP 1744 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 840FL UT WOS:000296424200023 PM 22047575 ER PT J AU Zander, NE Strawhecker, KE Orlicki, JA Rawlett, AM Beebe, TP AF Zander, Nicole E. Strawhecker, Kenneth E. Orlicki, Joshua A. Rawlett, Adam M. Beebe, Thomas P., Jr. TI Coaxial Electrospun Poly(methyl methacrylate)-Polyacrylonitrile Nanofibers: Atomic Force Microscopy and Compositional Characterization SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID POLYMER NANOFIBERS; CARBON NANOFIBERS; POROUS CARBON; FIBERS; FABRICATION; TECHNOLOGY; RELEASE; STORAGE AB Poly(methyl methacrylate) (PMMA)-polyacrylonitrile (PAN) fibers were prepared using a conventional single-nozzle electrospinning technique. The as-spun fibers exhibited core-shell morphology as verified by transmission electron microscopy (TEM) and atomic force microscopy (AFM). AFM-phase and modulus mapping images of the fiber cross-section and X-ray photoelectron spectroscopy (XPS) analysis indicated that PAN formed the shell and PMMA formed the core material. XPS, thermogravimetric analysis (TGA), and elemental analysis were used to determine fiber compositional information. Soaking the fibers in solvent demonstrated removal of the core material, generating hollow PAN fibers. C1 [Zander, Nicole E.; Strawhecker, Kenneth E.; Orlicki, Joshua A.; Rawlett, Adam M.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Zander, Nicole E.; Beebe, Thomas P., Jr.] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA. RP Zander, NE (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM nicole.e.zander.civ@mail.mil FU University of Delaware's Center of Biomedical Research Excellence entitled Molecular Design of Advanced Biomaterials, an NIH COBRE Center [2P20-RR017716]; U.S. Army FX This work was conducted at both the University of Delaware in Newark, DE, and the U.S. Army Research Laboratory in Aberdeen Proving Ground, MD. This work was supported by matching funds associated with the University of Delaware's Center of Biomedical Research Excellence entitled Molecular Design of Advanced Biomaterials, an NIH COBRE Center (2P20-RR017716), and by the U.S. Army. NR 30 TC 12 Z9 12 U1 7 U2 82 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD NOV 3 PY 2011 VL 115 IS 43 BP 12441 EP 12447 DI 10.1021/jp205577r PG 7 WC Chemistry, Physical SC Chemistry GA 837CY UT WOS:000296169900014 PM 21928836 ER PT J AU House, RL Kirschbrown, JR Mehl, BP Gabriel, MM Puccio, JA Parker, JK Papanikolas, JM AF House, Ralph L. Kirschbrown, Justin R. Mehl, Brian P. Gabriel, Michelle M. Puccio, Joseph A. Parker, James K. Papanikolas, John M. TI Characterizing Electron-Hole Plasma Dynamics at Different Points in Individual ZnO Rods SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID WHISPERING-GALLERY MODES; NANOWIRE LASERS; THIN-FILMS; MICROSCOPY; NANOSTRUCTURES; NANOTETRAPOD; EMISSION AB We have used two-photon emission microscopy to characterize the charge carrier dynamics at different locations within a single ZnO rod. Photoexcitation by a focused laser produces carriers (electrons and holes) in a localized region. Emission is detected using both time-integrated and time-resolved methods. Results show that the electron-hole plasma (EHP) state plays a larger role at the end of the rod compared to other points within the structure, where electron-hole recombination proceeds through an excitonic state. The origin of this spatial dependence is attributed to the physical confinement at the end of the structure that prevents an expansion of the photoexcited electron-hole cloud through processes such as carrier diffusion. Whispering gallery modes are identified as contributing to a periodic emission pattern along the length of the structure. C1 [House, Ralph L.; Kirschbrown, Justin R.; Mehl, Brian P.; Gabriel, Michelle M.; Puccio, Joseph A.; Parker, James K.; Papanikolas, John M.] Univ N Carolina, Dept Chem, Caudill Labs, Chapel Hill, NC 27599 USA. [Parker, James K.] USA, Div Chem Sci, Res Off, Res Triangle Pk, NC 27709 USA. RP Papanikolas, JM (reprint author), Univ N Carolina, Dept Chem, Caudill Labs, CB 3290, Chapel Hill, NC 27599 USA. EM john_papanikolas@unc.edu RI Kirschbrown, Justin/B-3636-2013 FU National Science Foundation [CHE-0809045]; U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-04-D-0004]; U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0001011] FX Support for R.L.H., J.R.K., and B.P.M. was provided by a grant from the National Science Foundation (CHE-0809045). Support for M.M.G. during the latter stages of the project was provided by a grant from the U.S. Army Research Laboratory and the U.S. Army Research Office under Contract Number W911NF-04-D-0004. The project also made use of instrumentation purchased by the UNC-EFRC on Solar Fuels and Next Generation Photovoltaics, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC0001011. NR 35 TC 7 Z9 7 U1 1 U2 23 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD NOV 3 PY 2011 VL 115 IS 43 BP 21436 EP 21442 DI 10.1021/jp207830h PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 837EB UT WOS:000296172800079 ER PT J AU Wagner, GW AF Wagner, George Wayne TI Decontamination of Chemical Warfare Agents Using Household Chemicals SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH LA English DT Article ID HYDROGEN-PEROXIDE AB Chemical warfare agents (CWA) such as VX (a V-type nerve agent), GD (a G-type nerve agent), and HD (a blister agent) are readily decontaminated using common household chemicals, such as ammonia-based cleaners, hydrogen peroxide, baking soda, washing soda, and rubbing alcohol, thus providing safe, cost-effective decontamination capability that is accessible to the general public. C1 USA, Edgewood Chem Biol Ctr, Attn RDCB DRP F, Aberdeen Proving Ground, MD 21010 USA. RP Wagner, GW (reprint author), USA, Edgewood Chem Biol Ctr, Attn RDCB DRP F, Aberdeen Proving Ground, MD 21010 USA. EM george.w.wagner22.civ@mail.mil FU Defense Threat Reduction Agency (DTRA) [BA06-DEC016, BA06DEC052] FX Support of this work was provided through the Defense Threat Reduction Agency (DTRA) (under Project Nos. BA06-DEC016 and BA06DEC052). NR 7 TC 9 Z9 9 U1 5 U2 26 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0888-5885 J9 IND ENG CHEM RES JI Ind. Eng. Chem. Res. PD NOV 2 PY 2011 VL 50 IS 21 BP 12285 EP 12287 DI 10.1021/ie201297e PG 3 WC Engineering, Chemical SC Engineering GA 836RH UT WOS:000296128300058 ER PT J AU Goldman, ER Anderson, GP Zabetakis, D Walper, S Liu, JL Bernstein, R Calm, A Carney, JP O'Brien, TW Walker, JL Garber, EAE AF Goldman, Ellen R. Anderson, George P. Zabetakis, Dan Walper, Scott Liu, Jinny L. Bernstein, Rachael Calm, Alena Carney, James P. O'Brien, Thomas W. Walker, Jennifer L. Garber, Eric A. E. TI Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin SO TOXINS LA English DT Article DE abrin; single domain antibody; reversible refolding ID RIBOSOME-INACTIVATING PROTEINS; HEAVY-CHAIN ANTIBODIES; BOTULINUM-A NEUROTOXIN; IN-VITRO SELECTION; PRECATORIUS AGGLUTININ; MONOCLONAL-ANTIBODIES; TOXINS ABRIN; RICIN; TOXICITY; VARIANTS AB Llama derived single domain antibodies (sdAb), the recombinantly expressed variable heavy domains from the unique heavy-chain only antibodies of camelids, were isolated from a library derived from llamas immunized with a commercial abrin toxoid preparation. Abrin is a potent toxin similar to ricin in structure, sequence and mechanism of action. The selected sdAb were evaluated for their ability to bind to commercial abrin as well as abrax (a recombinant abrin A-chain), purified abrin fractions, Abrus agglutinin protein related to abrin but with lower toxicity), ricin, and unrelated proteins. Isolated sdAb were also evaluated for their ability to refold after heat denaturation and ability to be used in sandwich assays as both capture and reporter elements. The best binders were specific for the Abrus agglutinin, showing minimal binding to purified abrin fractions or unrelated proteins. These binders had sub nM affinities and regained most of their secondary structure after heating to 95 degrees C. They functioned well in sandwich assays. Through gel analysis and the behavior of anti-abrin monoclonal antibodies, we determined that the commercial toxoid preparation used for the original immunizations contained a high percentage of Abrus agglutinin, explaining the selection of Abrus agglutinin binders. Used in conjunction with anti-abrin monoclonal and polyclonal antibodies, these reagents can fill a role to discriminate between the highly toxic abrin and the related, but much less toxic, Abrus agglutinin and distinguish between different crude preparations. C1 [Goldman, Ellen R.; Anderson, George P.; Zabetakis, Dan; Walper, Scott; Liu, Jinny L.] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA. [Bernstein, Rachael] Nova Res Inc, Alexandria, VA 22308 USA. [Calm, Alena; Carney, James P.] USA, Edgewood Chem Biol Ctr RDCB DRB C, Aberdeen Proving Ground, MD 21010 USA. [O'Brien, Thomas W.; Walker, Jennifer L.] Tetracore Inc, Rockville, MD 20850 USA. [Garber, Eric A. E.] US FDA, Ctr Food Safety & Appl Nutr, Off Regulatory Sci, Div Bioanalyt Chem, College Pk, MD 20740 USA. RP Goldman, ER (reprint author), USN, Res Lab, Ctr Biomol Sci & Engn, 4555 Overlook Ave SW, Washington, DC 20375 USA. EM ellen.goldman@nrl.navy.mil; george.anderson@nrl.navy.mil; daniel.zabetakis@nrl.navy.mil; scott.walper.ctr@nrl.navy.mil; jinny.liu@nrl.navy.mil; rachael267@gmail.com; alena.calm@us.army.mil; jpcarn@sandia.gov; tobrien@tetracore.com; jaldrich@tetracore.com; eric.garber@fda.hhs.gov RI Anderson, George/D-2461-2011 OI Anderson, George/0000-0001-7545-9893 FU JSTO-CBD/DTRA program [AA06SPO004-014]; Office of Naval Research NRL base funds FX This work was supported by JSTO-CBD/DTRA program AA06SPO004-014, and the Office of Naval Research NRL base funds. The opinions expressed here are those of the authors and do not represent those of the US Navy, the US Department of Defense, the Food and Drug Administration, or the US government. NR 49 TC 10 Z9 10 U1 1 U2 10 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD NOV PY 2011 VL 3 IS 11 BP 1405 EP 1419 DI 10.3390/toxins3111405 PG 15 WC Toxicology SC Toxicology GA 995BA UT WOS:000307980000003 PM 22174977 ER PT J AU Froude, JW Thullier, P Pelat, T AF Froude, Jeffrey W., II Thullier, Philippe Pelat, Thibaut TI Antibodies Against Anthrax: Mechanisms of Action and Clinical Applications SO TOXINS LA English DT Review DE anthrax toxins; protective antigen; lethal factor; edema factor; antibodies ID TOXIN PROTECTIVE ANTIGEN; CAPILLARY MORPHOGENESIS PROTEIN-2; NEUTRALIZING MONOCLONAL-ANTIBODY; EDEMA FACTOR-BINDING; BACILLUS-ANTHRACIS; LETHAL FACTOR; INHALATIONAL ANTHRAX; CRYSTAL-STRUCTURE; HIGH-AFFINITY; IN-VIVO AB B. anthracis is a bioweapon of primary importance and its pathogenicity depends on its lethal and edema toxins, which belong to the A-B model of bacterial toxins, and on its capsule. These toxins are secreted early in the course of the anthrax disease and for this reason antibiotics must be administered early, in addition to other limitations. Antibodies (Abs) may however neutralize those toxins and target this capsule to improve anthrax treatment, and many Abs have been developed in that perspective. These Abs act at various steps of the cell intoxication and their mechanisms of action are detailed in the present review, presented in correlation with structural and functional data. The potential for clinical application is discussed for Abs targeting each step of entry, with four of these molecules already advancing to clinical trials. Paradoxically, certain Abs may also enhance the lethal toxin activity and this aspect will also be presented. The unique paradigm of Abs neutralizing anthrax toxins thus exemplifies how they may act to neutralize A-B toxins and, more generally, be active against infectious diseases. C1 [Froude, Jeffrey W., II; Thullier, Philippe; Pelat, Thibaut] Inst Rech Biomed Armees IRBA CRSSA, Dept Microbiol, Unite Biotechnol Anticorps & Toxines, F-38702 La Tronche, France. [Froude, Jeffrey W., II] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Thullier, P (reprint author), Inst Rech Biomed Armees IRBA CRSSA, Dept Microbiol, Unite Biotechnol Anticorps & Toxines, F-38702 La Tronche, France. EM jeffrey.froude@us.army.mil; pthullier@yahoo.com; t.pelat@orange.fr FU Direction Generale de l'Armement [09co302-1] FX This review was made possible by Direction Generale de l'Armement funding, under no 09co302-1. NR 87 TC 16 Z9 17 U1 2 U2 11 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 2072-6651 J9 TOXINS JI Toxins PD NOV PY 2011 VL 3 IS 11 BP 1433 EP 1452 DI 10.3390/toxins3111433 PG 20 WC Toxicology SC Toxicology GA 995BA UT WOS:000307980000005 PM 22174979 ER PT J AU Oh, RC Hustead, TR AF Oh, Robert C. Hustead, Thomas R. TI Causes and Evaluation of Mildly Elevated Liver Transaminase Levels SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID FATTY LIVER; AMINOTRANSFERASE LEVELS; AUTOIMMUNE HEPATITIS; MEDICAL PROGRESS; CHEMISTRY TESTS; STATIN SAFETY; UNITED-STATES; DISEASE; DIAGNOSIS; HEPATOTOXICITY AB Mild elevations in levels of the liver enzymes alanine transaminase and aspartate transaminase are commonly discovered in asymptomatic patients in primary care. Evidence to guide the diagnostic workup is limited. If the history and physical examination do not suggest a cause, a stepwise evaluation should be initiated based on the prevalence of diseases that cause mild elevations in transaminase levels. The most common cause is nonalcoholic fatty liver disease, which can affect up to 30 percent of the population. Other common causes include alcoholic liver disease, medication-associated liver injury, viral hepatitis (hepatitis B and C), and hemochromatosis. Less common causes include alpha(1)-antitrypsin deficiency, autoimmune hepatitis, and Wilson disease. Extrahepatic conditions (e.g., thyroid disorders, celiac disease, hemolysis, muscle disorders) can also cause elevated liver transaminase levels. Initial testing should include a fasting lipid profile; measurement of glucose, serum iron, and ferritin; total iron-binding capacity; and hepatitis B surface antigen and hepatitis C virus antibody testing. If test results are normal, a trial of lifestyle modification with observation or further testing for less common causes is appropriate. Additional testing may include ultrasonography; measurement of alpha(1)-cantitrypsin and ceruloplasmin; serum protein electrophoresis; and antinuclear antibody, smooth muscle antibody, and liver/kidney microsomal antibody type 1 testing. Referral for further evaluation and possible liver biopsy is recommended if transaminase levels remain elevated for six months or more. (Am Fam Physician. 2011; 84 (9):1003-1008. Copyright (C) 2011 American Academy of Family Physicians.) C1 [Oh, Robert C.; Hustead, Thomas R.] Tripler Army Med Ctr, Family Med Residency Program, Honolulu, HI 96859 USA. [Hustead, Thomas R.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Oh, RC (reprint author), Tripler Army Med Ctr, Family Med Residency Program, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM robert.oh@us.army.mil NR 32 TC 18 Z9 19 U1 0 U2 4 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD NOV 1 PY 2011 VL 84 IS 9 BP 1003 EP 1008 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 980AK UT WOS:000306865800009 PM 22046940 ER PT J AU Hamilton, LR Cox, DM Myers, TM AF Hamilton, Lindsey R. Cox, David M. Myers, Todd M. TI Use of Operant Performance to Guide and Evaluate Medical Treatment in an Adult Male Cynomolgus Macaque (Macaca fascicularis) SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID BEHAVIOR AB A 6-y-old male cynomolgus macaque presented with noticeable swelling of the left forearm and signs of discomfort, as indicated by nonuse of the arm even in a behavioral task that he previously had been well-motivated to perform. Examination under anesthesia revealed lacerations to the arm. Radiography of the forearm showed no fractures, indicating that the damage was limited to soft tissue. The daily operant behavioral session assessed the amount of force the monkey emitted when touching the screen with the affected arm and how long each touch was sustained. We then used these parameters (force and duration of touch) as objective measures of putative pain relief and recovery of function to guide the medical treatment. The affected monkey received ketoprofen, buprenorphine, or their combination but continued to perform poorly during daily operant behavioral sessions. Only after treatment with dexamethasone did performance return to preinjury levels, suggesting inflammation near the radial or ulnar nerve. These findings indicate that performance of a trained operant task performance can be useful in guiding medical treatment, evaluating pain relief, and objectively monitoring health in laboratory animals. C1 [Hamilton, Lindsey R.; Myers, Todd M.] USA, Neurobehav Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Cox, David M.] USA, Vet Med & Surg Branch, Res Support Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. RP Myers, TM (reprint author), USA, Neurobehav Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. EM Todd.Myers2@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division FX We thank Mr Andrew Bonvillain for his technical assistance. The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Army, Department of Defense, or the US Government. This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical Science and Technology Division. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD NOV PY 2011 VL 50 IS 6 BP 946 EP 948 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 978UT UT WOS:000306772000016 PM 22330792 ER PT J AU Froude, JW Stiles, B Pelat, T Thullier, P AF Froude, Jeffrey W. Stiles, Bradley Pelat, Thibaut Thullier, Philippe TI Antibodies for biodefense SO MABS LA English DT Review DE antibody; anthrax; plague; smallpox; botulism; tularemia; brucellosis; hemorrhagic; ricin; SEB ID STAPHYLOCOCCAL-ENTEROTOXIN-B; VENEZUELAN EQUINE ENCEPHALITIS; HUMAN MONOCLONAL-ANTIBODY; BURKHOLDERIA-PSEUDOMALLEI INFECTION; PROTECTIVE ANTIGEN-ANTIBODY; LINKED-IMMUNOSORBENT-ASSAY; VACCINIA IMMUNE GLOBULIN; PUBLIC-HEALTH MANAGEMENT; SHIGA-LIKE TOXIN; BOTULINUM NEUROTOXIN AB Potential bioweapons are biological agents (bacteria, viruses and toxins) at risk of intentional dissemination. Biodefense, defined as development of therapeutics and vaccines against these agents, has seen an increase, particularly in the US, following the 2001 anthrax attack. This review focuses on recombinant antibodies and polyclonal antibodies for biodefense that have been accepted for clinical use. These antibodies aim to protect against primary potential bioweapons or category A agents as defined by the Centers for Disease Control and Prevention (Bacillus anthracis, Yersinia pestis, Francisella tularensis, botulinum neurotoxins, smallpox virus and certain others causing viral hemorrhagic fevers) and certain category B agents. Potential for prophylactic use is presented, as well as frequent use of oligoclonal antibodies or synergistic effect with other molecules. Capacities and limitations of antibodies for use in biodefense are discussed, and are generally applicable to the field of infectious diseases. C1 [Froude, Jeffrey W.; Pelat, Thibaut; Thullier, Philippe] Inst Rech Biomed Armees IRBA CRSSA, Unite Biotechnol Anticorps & Toxines, Dept Microbiol, La Tronche, France. [Froude, Jeffrey W.] USA, Med Res & Mat Command, Ft Detrick, MD USA. [Stiles, Bradley] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Thullier, P (reprint author), Inst Rech Biomed Armees IRBA CRSSA, Unite Biotechnol Anticorps & Toxines, Dept Microbiol, La Tronche, France. EM pthullier@yahoo.com NR 172 TC 20 Z9 25 U1 1 U2 11 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1942-0862 J9 MABS-AUSTIN JI mAbs PD NOV-DEC PY 2011 VL 3 IS 6 BP 517 EP 527 DI 10.4161/mabs.3.6.17621 PG 11 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 898PP UT WOS:000300754600004 PM 22123065 ER PT J AU Panther, JL Brown, RS Gaulke, GL Deters, KA Woodley, CM Eppard, MB AF Panther, Jennifer L. Brown, Richard S. Gaulke, Greg L. Deters, Katherine A. Woodley, Christa M. Eppard, M. Brad TI Influence of Incision Location on Transmitter Loss, Healing, Survival, Growth, and Suture Retention of Juvenile Chinook Salmon SO TRANSACTIONS OF THE AMERICAN FISHERIES SOCIETY LA English DT Article ID IMPLANTED DUMMY TRANSMITTERS; RAINBOW-TROUT; TEMPERATURE; WOUNDS; GUIDELINES; MORTALITY; RIVER AB Fisheries research involving surgical implantation of transmitters necessitates the use of methods that minimize transmitter loss and fish mortality and optimize healing of the incision. We evaluated the effects of three incision locations on transmitter loss, healing, survival, growth, and suture retention in juvenile Chinook salmon Oncorhynchus tshawytscha. The three incision locations were (1) on the linea alba (LA incision), (2) adjacent and parallel to the LA (muscle-cutting [MC] incision), and (3) extending from the LA towards the dorsum at a 45 degrees angle, between the parallel lines of myomeres (muscle-sparing [MS] incision). A Juvenile Salmon Acoustic Telemetry System acoustic transmitter (0.44 g in air) and a passive integrated transponder tag (0.10 g in air) were implanted into each fish (total N = 936 fish). The fish were held at 12 degrees C or 20 degrees C and were examined weekly for 98 d. The progression of healing among incision locations and the variability in transmitter loss made it difficult to identify one incision location as the best choice. The LA incisions had a much smaller wound extent (area of visible subepidermal tissue) than MC and MS incisions during the first 28 d of the study. In both temperature treatments, apposition of incisions through day 14 was better for LA incisions than for MC and MS incisions. However, MC and MS incisions were less likely than LA incisions to reopen over time and thus were less likely to allow transmitter loss through the incision. C1 [Panther, Jennifer L.; Brown, Richard S.; Gaulke, Greg L.; Deters, Katherine A.; Woodley, Christa M.] Pacific NW Natl Lab, Richland, WA 99354 USA. [Eppard, M. Brad] USA, Corps Engineers, Portland, OR 97204 USA. RP Panther, JL (reprint author), Confederated Tribes Colville Reservat, Fish & Wildlife Dept, 25B Mission Rd, Omak, WA 98841 USA. EM jennifer.panther@colvilletribes.com NR 32 TC 14 Z9 14 U1 0 U2 9 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0002-8487 J9 T AM FISH SOC JI Trans. Am. Fish. Soc. PD NOV PY 2011 VL 140 IS 6 BP 1492 EP 1503 DI 10.1080/00028487.2011.637003 PG 12 WC Fisheries SC Fisheries GA 903WU UT WOS:000301153700006 ER PT J AU Gibbons, MBC Rothbard, A Farris, KD Stirman, SW Thompson, SM Scott, K Heintz, LE Gallop, R Crits-Christoph, P AF Gibbons, Mary Beth Connolly Rothbard, Aileen Farris, Kimberly D. Stirman, Shannon Wiltsey Thompson, Sarah M. Scott, Kelli Heintz, Laura E. Gallop, Robert Crits-Christoph, Paul TI Changes in Psychotherapy Utilization Among Consumers of Services for Major Depressive Disorder in the Community Mental Health System SO ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES RESEARCH LA English DT Article DE Depression; Psychotherapy; Racial disparities; Community mental health system ID NATIONAL INSURED POPULATION; CARE; ATTITUDES; TRENDS AB The goal of this investigation was to explore changes in psychotherapy utilization for patients with major depressive disorder (MDD) treated in community mental health agencies across two cohorts. We used a Medicaid claims database including approximately 300,000 public sector clients. Although the use of psychotherapy alone showed a small decrease, there was a large increase in the use of combined medication and psychotherapy as a treatment for MDD. Race was a significant predictor of both treatment type received and length of treatment. African American consumers were more likely to receive psychotherapy alone than combined treatment and attended significantly fewer psychotherapy sessions. C1 [Gibbons, Mary Beth Connolly; Thompson, Sarah M.; Scott, Kelli; Heintz, Laura E.; Crits-Christoph, Paul] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA. [Stirman, Shannon Wiltsey] Boston Univ, Div Psychiat, Boston, MA 02215 USA. [Farris, Kimberly D.] USA, Behav & Social Hlth Outcomes Program, Publ Hlth Command, Aberdeen Proving Ground, MD USA. [Gallop, Robert] W Chester Univ, Dept Math, W Chester, PA 19380 USA. [Rothbard, Aileen] Univ Penn, Sch Social Policy & Practice, Philadelphia, PA 19104 USA. [Rothbard, Aileen] Univ Penn, Ctr Mental Hlth Policy & Serv Res, Philadelphia, PA 19104 USA. RP Thompson, SM (reprint author), Univ Penn, Dept Psychiat, 3535 Market St,Suite 664, Philadelphia, PA 19104 USA. EM sarahtho@mail.med.upenn.edu NR 15 TC 5 Z9 5 U1 0 U2 4 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 0894-587X J9 ADM POLICY MENT HLTH JI Adm. Policy. Ment. Health PD NOV PY 2011 VL 38 IS 6 BP 495 EP 503 DI 10.1007/s10488-011-0336-1 PG 9 WC Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA 889SE UT WOS:000300092700006 ER PT J AU Shkuratov, SI Baird, J Talantsev, EF Altgilbers, LL AF Shkuratov, Sergey I. Baird, Jason Talantsev, Evgueni F. Altgilbers, Larry L. TI Imaging of Electric-Field-Free Gas Breakdown SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article DE Explosions; electric breakdown; shock waves AB Images of electric-field-free gas breakdown are presented. Possible mechanism of the breakdown is proposed. C1 [Shkuratov, Sergey I.] Loki Inc, Rolla, MO 65409 USA. [Baird, Jason] Loki Inc, Rolla, MO 65401 USA. [Baird, Jason] Missouri Univ Sci & Technol, Dept Min & Nucl Engn, Rolla, MO 65409 USA. [Talantsev, Evgueni F.] Pulsed Power LLC, Lubbock, TX 79416 USA. [Altgilbers, Larry L.] USA, Space & Missile Def Command, Army Forces Strateg Command, Huntsville, AL 35807 USA. RP Shkuratov, SI (reprint author), Loki Inc, Rolla, MO 65409 USA. EM shkuratov@lokiconsult.com OI Talantsev, Evgeny/0000-0001-8970-7982 NR 7 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD NOV PY 2011 VL 39 IS 11 SI SI BP 2386 EP 2387 DI 10.1109/TPS.2011.2128892 PN 1 PG 2 WC Physics, Fluids & Plasmas SC Physics GA 884CV UT WOS:000299683400166 ER PT J AU Avirutnan, P Hauhart, RE Marovich, MA Garred, P Atkinson, JP Diamond, MS AF Avirutnan, Panisadee Hauhart, Richard E. Marovich, Mary A. Garred, Peter Atkinson, John P. Diamond, Michael S. TI Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin SO MBIO LA English DT Article ID IMMUNOGLOBULIN-G ANTIBODIES; MBL2 GENE POLYMORPHISMS; DC-SIGN; ENVELOPE GLYCOPROTEINS; MONOCLONAL-ANTIBODIES; CANDIDA-ALBICANS; DENDRITIC CELLS; INFECTION; PROTEIN; RECOGNITION AB Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial agents and initiates complement activation via the lectin pathway. Prior studies showed that MBL-dependent activation of the complement cascade neutralized insect cell-derived West Nile virus (WNV) in cell culture and restricted pathogenesis in mice. Here, we investigated the antiviral activity of MBL in infection by dengue virus (DENV), a related flavivirus. Using a panel of naive sera from mouse strains deficient in different complement components, we showed that inhibition of infection by insect cell- and mammalian cell-derived DENV was primarily dependent on the lectin pathway. Human MBL also bound to DENV and neutralized infection of all four DENV serotypes through complement activation-dependent and -independent pathways. Experiments with human serum from naive individuals with inherent variation in the levels of MBL in blood showed a direct correlation between the concentration of MBL and neutralization of DENV; samples with high levels of MBL in blood neutralized DENV more efficiently than those with lower levels. Our studies suggest that allelic variation of MBL in humans may impact complement-dependent control of DENV pathogenesis. IMPORTANCE Dengue virus (DENV) is a mosquito-transmitted virus that causes a spectrum of clinical disease in humans ranging from subclinical infection to dengue hemorrhagic fever and dengue shock syndrome. Four serotypes of DENV exist, and severe illness is usually associated with secondary infection by a different serotype. Here, we show that mannose-binding lectin (MBL), a pattern recognition molecule that initiates the lectin pathway of complement activation, neutralized infection of all four DENV serotypes through complement activation-dependent and -independent pathways. Moreover, we observed a direct correlation with the concentration of MBL in human serum and neutralization of DENV infection. Our studies suggest that common genetic polymorphisms that result in disparate levels and function of MBL in humans may impact DENV infection, pathogenesis, and disease severity. C1 [Avirutnan, Panisadee; Hauhart, Richard E.; Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA. [Avirutnan, Panisadee] Mahidol Univ, Siriraj Hosp, Fac Med, Hemorrhag Fever Res Unit,Off Res & Dev, Bangkok 10700, Thailand. [Marovich, Mary A.] Walter Reed Army Inst Res, Mol Med Lab, Div Retrovirol, Rockville, MD USA. [Marovich, Mary A.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Garred, Peter] Univ Copenhagen, Rigshosp, Dept Clin Immunol, Fac Hlth Sci, DK-2100 Copenhagen, Denmark. [Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA. [Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA. [Diamond, Michael S.] Washington Univ, Sch Med, Midwest Reg Ctr Excellence Biodef & Emerging Infe, St Louis, MO 63110 USA. RP Diamond, MS (reprint author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA. EM sifav@mahidol.ac.th; diamond@borcim.wustl.edu FU Midwest Regional Center for Excellence for Biodefense Emerging Infectious Disease Research [U54-AI057160]; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DoD) [W81XWH-07-2-0067]; NIH from the Division of Rheumatology in the Department of Medicine, Washington University School of Medicine; Mahidol University FX This work was supported by the Midwest Regional Centers for Excellence for Biodefense and Emerging Infectious Disease Research (U54-AI057160) and a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DoD). P. Avirutnan was supported by an NIH postdoctoral training grant from the Division of Rheumatology in the Department of Medicine, Washington University School of Medicine and a grant from Mahidol University. NR 57 TC 9 Z9 10 U1 0 U2 8 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 2150-7511 J9 MBIO JI mBio PD NOV-DEC PY 2011 VL 2 IS 6 AR e00276-11 DI 10.1128/mBio.00276-11 PG 11 WC Microbiology SC Microbiology GA 888GV UT WOS:000299992700023 ER PT J AU Samy, RP Stiles, BG Gopalakrishnakone, P Chow, VTK AF Samy, R. P. Stiles, B. G. Gopalakrishnakone, P. Chow, V. T. K. TI Antimicrobial Proteins from Snake Venoms: Direct Bacterial Damage and Activation of Innate Immunity Against Staphylococcus aureus Skin Infection SO CURRENT MEDICINAL CHEMISTRY LA English DT Review DE Antimicrobial; Staphylococcus aureus; wound healing; fusidic acid ointment ID ALLIGATOR ALLIGATOR-MISSISSIPPIENSIS; MYOTOXIC PHOSPHOLIPASES A(2); BETA-LACTAM ANTIBIOTICS; TOLL-LIKE RECEPTORS; KING-BROWN SNAKE; DURISSUS-TERRIFICUS VENOM; NEUWIEDI-PAULOENSIS VENOM; AMINO-ACID-SEQUENCES; PSEUDECHIS-AUSTRALIS; STRUCTURAL-CHARACTERIZATION AB The innate immune system is the first line of defense against microbial diseases. Antimicrobial proteins produced by snake venoms have recently attracted significant attention due to their relevance to bacterial infection and potential development into new therapeutic agents. Staphylococcus aureus is one of the major human pathogens causing a variety of infections involving pneumonia, toxic shock syndrome, and skin lesions. With the recent emergence of methicillin (MRSA) and vancomycin (VRSA) resistance, S. aureus infection is a serious clinical problem that will have a grave socio-economic impact in the near future. Although S. aureus susceptibility to innate antimicrobial peptides has been reported recently, the protective effect of snake venom phospholipase A(2) (svPLA(2)) proteins on the skin from S. aureus infection has been understudied. This review details the protective function of svPLA(2)s derived from venoms against skin infections caused by S. aureus. We have demonstrated in vivo that local application of svPLA(2) provides complete clearance of S. aureus within 2 weeks after treatment compared to fusidic acid ointment (FAO). In vitro experiments also demonstrate that svPLA(2) proteins have inhibitory (bacteriostatic) and killing (bactericidal) effects on S. aureus in a dose-dependant manner. The mechanism of bacterial membrane damage and perturbation was clearly evidenced by electron microscopic studies. In summary, svPLA(2)s from Viperidae and Elapidae snakes are novel molecules that can activate important mechanisms of innate immunity in animals to endow them with protection against skin infection caused by S. aureus. C1 [Samy, R. P.; Gopalakrishnakone, P.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, Venom & Toxin Res Programme, Singapore 117597, Singapore. [Samy, R. P.; Chow, V. T. K.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol, Infect Dis Programme, Singapore 117597, Singapore. [Stiles, B. G.] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Stiles, B. G.] Wilson Coll, Chambersburg, PA 17201 USA. RP Samy, RP (reprint author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, Venom & Toxin Res Programme, Singapore 117597, Singapore. EM micramar@nus.edu.sg NR 165 TC 6 Z9 6 U1 1 U2 11 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8673 EI 1875-533X J9 CURR MED CHEM JI Curr. Med. Chem. PD NOV PY 2011 VL 18 IS 33 BP 5104 EP 5113 PG 10 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 875LI UT WOS:000299031000009 PM 22050758 ER PT J AU McGann, P Kwak, YI Summers, A Cummings, JF Waterman, PE Lesho, EP AF McGann, Patrick Kwak, Yoon I. Summers, Amy Cummings, James F. Waterman, Paige E. Lesho, Emil P. TI Detection of qacA/B in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus from a Regional Healthcare Network in the Eastern United States SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID GENES; BIOCIDES AB We describe the clinical, microbiologic, and molecular features of the first series of qacA/B-containing strains of methicillin-resistant Staphylococcus aureus from infected US patients. All qac-carrying strains were clonally diverse, and qacA strains exhibited increased tolerance to chlorhexidine as measured by minimum inhibitory concentrations, minimum bactericidal concentrations, and postexposure colony counts. Infect Control Hosp Epidemiol 2011; 32(11): 1116-1119 C1 [McGann, Patrick; Kwak, Yoon I.; Summers, Amy; Waterman, Paige E.; Lesho, Emil P.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA. [Cummings, James F.] Walter Reed Army Inst Res, Dept Regulated Act, Silver Spring, MD 20910 USA. RP McGann, P (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, 503 Robert Grant Ave,1E06, Silver Spring, MD 20910 USA. EM patrick.t.mcgann.ctr@us.army.mil FU US Army Medical Command Performance Improvement Initiative FX Financial support. Funding was provided by the US Army Medical Command Performance Improvement Initiative. NR 10 TC 22 Z9 22 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD NOV PY 2011 VL 32 IS 11 BP 1116 EP 1119 DI 10.1086/662380 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 876CB UT WOS:000299083500010 PM 22011540 ER PT J AU Kerr, R Holladay, J Holladay, S Tannenbaum, L Selcer, B Meldrum, B Williams, S Jarrett, T Gogal, R AF Kerr, Richard Holladay, Jeremy Holladay, Steven Tannenbaum, Lawrence Selcer, Barbara Meldrum, Blair Williams, Susan Jarrett, Timothy Gogal, Robert TI Oral Lead Bullet Fragment Exposure in Northern Bobwhite (Colinus virginianus) SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID ECOLOGICAL RISK-ASSESSMENT; BLOOD CHARACTERISTICS; JAPANESE-QUAIL; MOURNING DOVES; SHOT; ACID; TOXICITY; BIRDS; ZINC; RETENTION AB Lead (Pb) is a worldwide environmental contaminant known to adversely affect multiple organ systems in both mammalian and avian species. In birds, a common route of exposure is via oral ingestion of lead particles. Data are currently lacking for the retention and clearance of Pb bullet fragments in gastrointestinal (GI) tract of birds while linking toxicity with blood Pb levels. In the present study, northern bobwhite quail fed a seed-based diet were orally gavaged with Pb bullet fragments (zero, one or five fragments/bird) and evaluated for rate of fragment clearance, and changes in peripheral blood, renal, immune, and gastrointestinal parameters. Based on radiographs, the majority of the birds cleared or absorbed the fragments by seven days, with the exception of one five-fragment bird which took between 7 and 14 days. Blood Pb levels were higher in males than females, which may be related to egg production in females. In males but not females, feed consumption, body weight gain, packed cell volume (PCV), plasma protein concentration, and delta-aminolevulinic acid dehydratase (delta-ALAD) activity were all adversely affected by five Pb fragments. Birds of both sexes that received a single Pb fragment displayed depressed delta-ALAD, suggesting altered hematologic function, while all birds dosed with five bullet fragments exhibited greater morbidity. C1 [Kerr, Richard; Holladay, Steven; Selcer, Barbara; Jarrett, Timothy; Gogal, Robert] Univ Georgia, Coll Vet Med, Dept Anat & Radiol, Athens, GA 30602 USA. [Kerr, Richard] Univ Georgia, Coll Vet Med, Dept Vet Pathol, Athens, GA USA. [Tannenbaum, Lawrence] USA, Inst Publ Hlth, Aberdeen, MD USA. [Meldrum, Blair] Virginia Tech, Dept Biomed Sci & Pathobiol, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA USA. [Williams, Susan] Univ Georgia, Coll Vet Med, Dept Populat Hlth, Poultry Diagnost & Res Ctr, Athens, GA USA. RP Gogal, R (reprint author), Univ Georgia, Coll Vet Med, Dept Anat & Radiol, Athens, GA 30602 USA. EM rgogal@uga.edu NR 32 TC 4 Z9 4 U1 0 U2 24 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD NOV PY 2011 VL 61 IS 4 BP 668 EP 676 DI 10.1007/s00244-011-9654-2 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 868CG UT WOS:000298500700013 PM 21360077 ER PT J AU Sanders, JE Chuang, A Swiec, GD Bisch, FC Herold, RW Buxton, TB McPherson, JC AF Sanders, Jill E. Chuang, Augustine Swiec, Gary D. Bisch, Fredrick C. Herold, Robert W. Buxton, Thomas B. McPherson, James C., III TI The Effects of Enamel Matrix Derivative and Cyclic Mechanical Strain on Human Gingival Fibroblasts in an In Vitro Defect Healing Model SO INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY LA English DT Article ID CORONALLY ADVANCED FLAPS; PERIODONTAL-LIGAMENT; INTRABONY DEFECTS; CELLS; RECESSION; PROTEINS; CULTURE; TISSUE AB Gingival fibroblasts (GFs) play a considerable role in the maintenance of the gingival apparatus as well as in connective tissue repair. Mobility of a periodontal wound or soft tissue graft can impair connective tissue healing from the GFs. Enamel matrix derivative (EMD) is an enamel matrix protein used clinically for periodontal regeneration of intrabony defects and furcations, as well as treatment of gingival margin recessions. The goal of this project was to compare the effects of varying concentrations of EMD, with and without cyclic mechanical strain, on cellular wound fill of human GFs using an in vitro defect healing model. GFs were seeded and cultured in six-well flexible-bottomed plates. A 3-mm wound was created in the central portion of each confluent well. Three wells were treated with each EMD concentration of 0 mu g/mL (control), 30 mu g/mL, 60 mu g/mL, or 120 mu g/mL. The plates were placed in an incubator containing a strain unit to subject test plates to cyclic strain. An identical set of control plates were not flexed. Cells were examined on days 4, 8, 12, and 16. Microphotographs were taken and wound fill measurements made using image analysis software. The percent wound fill was calculated. All nonflexed plates, regardless of EMD concentration, reached > 90% defect fill at similar rates by day 16. However, in the flexed plates, EMD had a significant negative effect on defect fill. The defect fill was 55.7% for 0 mu g/mL EMD, 48.2% for 30 mu g/mL EMD, 36.7% for 60 mu g/mL EMD, and 34.1% for 120 mu g/mL EMD on day 16 for the flexed GFs. EMD, in concentrations as high as 120 mu g/mL, did not significantly affect the amount of defect fill with nonflexed GFs. However, when the GFs were flexed, the addition of EMD had a significant negative effect on defect fill in a dose-dependent manner. (Int J Periodontics Restorative Dent 2011; 31: 671-678.) C1 [Sanders, Jill E.; Swiec, Gary D.; Bisch, Fredrick C.; Herold, Robert W.] USA, Adv Training Program Periodont, Ft Gordon, GA USA. [Chuang, Augustine; Buxton, Thomas B.; McPherson, James C., III] Dept Clin Invest, Ft Gordon, GA USA. RP Herold, RW (reprint author), Tignor Dent Clin, DC, COL, 669 Monroe Ave, Ft Eustis, VA 23604 USA. EM robert.herold1@us.army.mil NR 16 TC 4 Z9 4 U1 0 U2 0 PU QUINTESSENCE PUBLISHING CO INC PI HANOVER PARK PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA SN 0198-7569 J9 INT J PERIODONT REST JI Int. J. Periodontics Restor. Dent. PD NOV-DEC PY 2011 VL 31 IS 6 BP 671 EP 678 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 868ST UT WOS:000298546400016 PM 22140669 ER PT J AU Jackson, WM Lozito, TP Djouad, F Kuhn, NZ Nesti, LJ Tuan, RS AF Jackson, Wesley M. Lozito, Thomas P. Djouad, Farida Kuhn, Nastaran Z. Nesti, Leon J. Tuan, Rocky S. TI Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE LA English DT Article DE mesenchymal stem cells; progenitor cells; tissue engineering; regenerative medicine; immunoregulation; angiogenesis ID HUMAN BONE-MARROW; STEM-CELLS; SKELETAL-MUSCLE; CLINICAL-APPLICATIONS; STROMAL CELLS; EXPRESSION; TRANSPLANTATION; POPULATION; THERAPY; BIOLOGY AB Mesenchymal stem cell (MSC) therapy is a promising approach to promote tissue regeneration by either differentiating the MSCs into the desired cell type or by using their trophic functions to promote endogenous tissue repair. These strategies of regenerative medicine are limited by the availability of MSCs at the point of clinical care. Our laboratory has recently identified multipotent mesenchymal progenitor cells (MPCs) in traumatically injured muscle tissue, and the objective of this study was to compare these cells to a typical population of bone marrow derived MSCs. Our hypothesis was that the MPCs exhibit multilineage differentiation and expression of trophic properties that make functionally them equivalent to bone marrow derived MSCs for tissue regeneration therapies. Quantitative evaluation of their proliferation, metabolic activity, expression of characteristic cell-surface markers and baseline gene expression profile demonstrate substantial similarity between the two cell types. The MPCs were capable of differentiation into osteoblasts, adipocytes and chondrocytes, but they appeared to demonstrate limited lineage commitment compared to the bone marrow derived MSCs. The MPCs also exhibited trophic (i.e. immunoregulatory and pro-angiogenic) properties that were comparable to those of MSCs. These results suggest that the traumatized muscle derived MPCs may not be a direct substitute for bone marrow derived MSCs. However, because of their availability and abundance, particularly following orthopaedic injuries when traumatized muscle is available to harvest autologous cells, MPCs are a promising cell source for regenerative medicine therapies designed to take advantage of their trophic properties. C1 [Lozito, Thomas P.; Tuan, Rocky S.] Univ Pittsburgh, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, Sch Med, Pittsburgh, PA 15219 USA. [Jackson, Wesley M.; Lozito, Thomas P.; Djouad, Farida; Kuhn, Nastaran Z.; Nesti, Leon J.; Tuan, Rocky S.] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Jackson, Wesley M.; Nesti, Leon J.] NIAMSD, Clin & Expt Othopaed Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. [Nesti, Leon J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Tuan, RS (reprint author), Univ Pittsburgh, Ctr Cellular & Mol Engn, Dept Orthopaed Surg, Sch Med, 450 Technol Dr,Room 221, Pittsburgh, PA 15219 USA. EM rst13@pitt.edu OI Djouad, Farida/0000-0001-8248-6822 FU Walter Reed Army Medical Center [PO5-A011]; Comprehensive Neurosciences Program [CNP-2008-CR01]; NIH [Z01 AR41131]; University of Pennsylvania, Department of Health FX Support was provided by the Military Amputee Research Program at Walter Reed Army Medical Center (PO5-A011), the Comprehensive Neurosciences Program (CNP-2008-CR01), the NIH Intramural Research Program (Z01 AR41131) and the University of Pennsylvania, Department of Health. Immunophenotyping was performed in the NIAMS Flow Cytometry Group with the assistance of James Simone. Technical assistance was provided by Jun Onodera, Yingjie Song and Ibardo Zambrano. We thank Dr. Paul Manner, Department of Orthopaedic Surgery at the University of Washington, for providing human skeletal tissues. NR 56 TC 14 Z9 16 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1582-4934 J9 J CELL MOL MED JI J. Cell. Mol. Med. PD NOV PY 2011 VL 15 IS 11 BP 2377 EP 2388 DI 10.1111/j.1582-4934.2010.01225.x PG 12 WC Cell Biology; Medicine, Research & Experimental SC Cell Biology; Research & Experimental Medicine GA 859DQ UT WOS:000297855400011 PM 21129154 ER PT J AU Deng, BL Medina, V Reed, C Bednar, A Griggs, C Dontsova, KM Nestler, CC AF Deng, Baolin Medina, Victor Reed, Candice Bednar, Anthony Griggs, Chris Dontsova, Katrina M. Nestler, Catherine C. TI Uptake of Cesium (Cs+) by Building Materials in Aqueous Batch Systems SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article DE Cesium; Dirty bomb; Sorption; Building materials ID DIRTY BOMB; SURFACE; EMULSIONS; ACCIDENT; GOIANIA AB Cesium-137 (C-137) is a radioactive source that could be utilized in the construction of a radioactive dispersal device (RDD). The objective of this study was to examine the uptake of Cs+ by common structural materials in the presence of water by using batch experiments with nonradioactive cesium chloride ((CsCl)-Cs-133) as a surrogate for the radionuclide. Uptake kinetics and adsorption isotherms of Cs+ were measured on a diverse set of building materials, as were the effects of pH on the sorption processes. The results showed that wood materials, metal filings, and organic building materials and supplies did not sorb significant amounts of Cs+, but red brick, concrete block, drop ceiling panels, and clay materials retained Cs+ strongly. Adsorption kinetics were fast, and sorption isotherms could be characterized as linear. The solution pH did not have a significant effect on Cs+ sorption. DOI: 10.1061/(ASCE)EE.1943-7870.0000425. (C) 2011 American Society of Civil Engineers. C1 [Deng, Baolin] Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. [Medina, Victor; Bednar, Anthony; Griggs, Chris; Dontsova, Katrina M.] USA, Environm Lab, Corps Engineers Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Reed, Candice] Sherman Ave Elementary Sch, MPH, Vicksburg, MS 39183 USA. [Nestler, Catherine C.] Appl Res Associates, Vicksburg, MS 39180 USA. RP Deng, BL (reprint author), Univ Missouri, Dept Civil & Environm Engn, Columbia, MO 65211 USA. EM dengb@missouri.edu OI Deng, Baolin/0000-0001-6569-1808 FU ERDC through the U.S. Army Research Office [W911NF-07-D-0001]; U.S. Army Research, Development, and Engineering Command/Armaments Research, Development and Engineering Center (RDECOM/ARDEC) FX The authors greatly appreciate the analytical assistance provided by Michelle Thompson and the advice on BET analysis by Dr. Jeffery A. Steevens, both at the U.S. Army Engineer Research and Development Center, Vicksburg, Mississippi. This work was supported by the ERDC through the U.S. Army Research Office Scientific Services Program administered by Battelle (Delivery Order 0044, Contract No. W911NF-07-D-0001). ERDC was funded by the U.S. Army Research, Development, and Engineering Command/Armaments Research, Development and Engineering Center (RDECOM/ARDEC). The use of trade, product, or firm names are for descriptive purposes only and do not imply endorsement by the U.S. government. The views, opinions, and/or findings contained in this report are those of the authors and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other documentation. NR 16 TC 1 Z9 1 U1 1 U2 17 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD NOV PY 2011 VL 137 IS 11 BP 990 EP 995 DI 10.1061/(ASCE)EE.1943-7870.0000425 PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 864NU UT WOS:000298247700002 ER PT J AU Barna, LA Seman, PM Korhonen, CJ AF Barna, Lynette A. Seman, Peter M. Korhonen, Charles J. TI Energy-Efficient Approach to Cold-Weather Concreting SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING LA English DT Article DE Cold-weather concrete; Portland cement; Concrete admixtures; Concrete freezing; Freeze-thaw durability; Compressive strength AB Conventional cold-weather concreting is expensive and very energy inefficient. Common practice requires artificial heating of the raw materials and the surrounding environment to create suitable curing conditions for normal concrete. Antifreeze concrete is a new approach to cold-weather concreting without the need for artificial heating. This saves time, money, and energy. The antifreeze concrete technology has been proven in numerous full-scale field demonstrations and is compatible with current concrete construction practices. A laboratory study established the practicality of using antifreeze concrete and developed the tools to mix and cure concrete in subfreezing temperatures. Eight candidate antifreeze formulations were developed in the laboratory and subjected to initial screening tests that showed they were capable of being workable, entraining air, and meeting the design freezing point. Performance testing showed that the strength gain when cured at -4 degrees C is as good as conventional concrete cured at +5 degrees C and that antifreeze mixtures can be made durable. High dosages of chemical admixture used in antifreeze concrete mixtures were not harmful to the concrete. It is recommended that agencies conduct testing on their own to become familiar with the antifreeze mixtures before widespread use. DOI: 10.1061/(ASCE)MT.1943-5533.0000262. (C) 2011 American Society of Civil Engineers. C1 [Barna, Lynette A.; Seman, Peter M.] USA, Engn Res & Dev Ctr, CRREL, Hanover, NH 03755 USA. [Korhonen, Charles J.] ARCTIKOR, Chassell, MI 49916 USA. RP Barna, LA (reprint author), USA, Engn Res & Dev Ctr, CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Lynette.A.Barna@usace.army.mil; Peter.M.Seman@usace.army.mil; korhonenc@hotmail.com NR 22 TC 3 Z9 3 U1 1 U2 6 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0899-1561 J9 J MATER CIVIL ENG JI J. Mater. Civ. Eng. PD NOV PY 2011 VL 23 IS 11 SI SI BP 1544 EP 1551 DI 10.1061/(ASCE)MT.1943-5533.0000262 PG 8 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA 864NP UT WOS:000298247200008 ER PT J AU Pilakasiri, K Molee, P Sringernyuang, D Sangjun, N Channasanon, S Tanodekaew, S AF Pilakasiri, Kajee Molee, Patamaporn Sringernyuang, Duangkamol Sangjun, Noppadon Channasanon, Somruethai Tanodekaew, Siriporn TI Efficacy of chitin-PAA-GTMAC gel in promoting wound healing: animal study SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE LA English DT Article ID CELL NUCLEAR ANTIGEN; DNA POLYMERASE-DELTA; ANTIMICROBIAL ACTIVITY; AUXILIARY PROTEIN; CHITOSAN; PROLIFERATION; EXPRESSION; PCNA; SKIN AB Acrylic grafted chitin (chitin-PAA) was modified with glycidyltrimethylammonium chloride (GTMAC) with the aim of promoting wound healing. The chitin-PAA-GTMAC gels with different GTMAC contents were compared with the original chitin-PAA gel and Intrasite gel for their efficacy in deep wound healing of Wistar rats. Four full-thickness wounds were made on the dorsal skin of rats and then each was treated with 4 materials; chitin-PAA, chitin-PAA-GTMAC(1:4), chitin-PAA-GTMAC(1:10) and Intrasite gel. During 18 days of treatment, the wounds were visually observed and calculated for wound size using image analysis program. Skin wound tissues of sacrificed rats were processed for routine histological observation and immunohistochemistry of proliferating cell nuclear antigen (PCNA). The wounds covered with the chitin derivatives either with or without GTMAC showed a significant reduction in wound size in day 9 in comparison with day 12 for those covered with Intrasite gel. The faster rate and the better pattern of epidermal development observed in histological study as well as the higher dermal cell proliferation (PCNA expression) also demonstrated the better efficiency in wound healing of the chitin derivatives than Intrasite. The earliest epidermal development of the wounds treated with chitin-PAA-GTMAC (1:4) among the tested materials suggested the most promising of this material for the treatment of full-thickness open wound. C1 [Channasanon, Somruethai; Tanodekaew, Siriporn] Natl Met & Mat Technol Ctr, Klongluang 12120, Pathumthani, Thailand. [Sangjun, Noppadon] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Pilakasiri, Kajee; Molee, Patamaporn; Sringernyuang, Duangkamol] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand. RP Tanodekaew, S (reprint author), Natl Met & Mat Technol Ctr, 114 Thailand Sci Pk,Paholyothin Rd,Klong 1, Klongluang 12120, Pathumthani, Thailand. EM siriporn@mtec.or.th FU National Metal and Materials Technology Center, Thailand FX This research work was financially supported by National Metal and Materials Technology Center, Thailand. NR 24 TC 6 Z9 7 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4530 J9 J MATER SCI-MATER M JI J. Mater. Sci.-Mater. Med. PD NOV PY 2011 VL 22 IS 11 BP 2497 EP 2504 DI 10.1007/s10856-011-4420-6 PG 8 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA 856EZ UT WOS:000297621900011 PM 21853338 ER PT J AU Ebersole, BA Dean, RG Hughes, SA AF Ebersole, Bruce A. Dean, Robert G. Hughes, Steven A. TI Discussion of "Simulated Wave-Induced Erosion of the Mississippi River-Gulf Outlet Levees during Hurricane Katrina" by Rune Storesund, Robert G. Bea, and Yuli Huang SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Editorial Material C1 [Ebersole, Bruce A.; Hughes, Steven A.] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Dean, Robert G.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA. RP Hughes, SA (reprint author), USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Bruce.A.Ebersole@usace.army.mil; dean@coastal.ufl.edu; Steven.A.HughesPE@gmail.com NR 8 TC 0 Z9 0 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 2011 VL 137 IS 6 BP 355 EP 360 DI 10.1061/(ASCE)WW.1943-5460.0000083 PG 6 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 864OG UT WOS:000298248900009 ER PT J AU Kim, JB Kirchhoff, M Whitsett, S AF Kim, John B. Kirchhoff, Maureen Whitsett, Stan TI Expressive arts group therapy with middle-school aged children from military families SO ARTS IN PSYCHOTHERAPY LA English DT Article DE Expressive arts therapy; Multi-modal expressive arts; Group therapy; Erikson psychosocial developmental model; Maslow's hierarchy of needs; Military families and children ID DEPLOYMENT; PARENTS; IMPACT AB This article describes the development and implementation of an eight-session expressive arts group therapy provided at a middle school on an active military base with youth from active military families. The structure and process of expressive arts group therapy is described with reference to goals and objectives and the integration of the multi-modal expressive arts approach within a psychosocial developmental model relevant to the middle school youth. Principles from expressive arts therapy are also discussed and illustrated in the description and discussion of the eight sessions of the group therapy process. The reader is informed as to the value of group therapy to this age group, and its relevance to middle school aged children from military families. A brief review of literature on issues relevant to military families and middle-school aged children is also included. Published by Elsevier Inc. C1 [Kim, John B.; Kirchhoff, Maureen; Whitsett, Stan] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kim, JB (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM jblaisekim@gmail.com; mkirchhoff@yahoo.com NR 20 TC 3 Z9 3 U1 0 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0197-4556 J9 ART PSYCHOTHER JI Arts Psychother. PD NOV PY 2011 VL 38 IS 5 BP 356 EP 362 DI 10.1016/j.aip.2011.08.003 PG 7 WC Psychology, Clinical; Rehabilitation SC Psychology; Rehabilitation GA 855LP UT WOS:000297566200007 ER PT J AU Mitchell, LA Kitley, CA Armitage, TL Krasnokutsky, MV Rooks, VJ AF Mitchell, L. A. Kitley, C. A. Armitage, T. L. Krasnokutsky, M. V. Rooks, V. J. TI Normal Sagittal and Coronal Suture Widths by Using CT Imaging SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article ID CRANIAL SUTURES; HEAD TRAUMA; SKULL; AGE AB BACKGROUND AND PURPOSE: Pediatric cranial sutures are often evaluated for abnormal diastasis upon presentation to the emergency department after trauma or during a neurologic consultation; however, few normative data for CT measurements exist. This study establishes normal means for the sagittal and coronal suture widths during the first year of life by using CT. MATERIALS AND METHODS: The sagittal suture and bilateral coronal sutures were evaluated for 483 patients, ages 1 day to 395 days collected retrospectively from electronic medical records. Histograms as well as normality and boxplots were used to view the distribution of the data. An analysis of variance was performed for each suture measured by using month of age as the independent class variable. RESULTS: The average proximal suture widths for the sagittal and coronal sutures at zero months of age were 5.0 +/- 0.2 and 2.5 +/- 0.1 mm, respectively. From zero to 1 month of age, these sutures narrowed significantly to 2.4 +/- 0.1 and 1.3 +/- 0.1 mm, respectively. From 1 to 12 months of age, sutures narrowed gradually. The proximal coronal suture widths showed a significant reduction from 1 month to 12 months (1.3 +/- 0.1-0.8 +/- 0.1 mm). CONCLUSIONS: The normative values for suture widths established by CT scan among this large population may be used to assess the infant calvaria for suture diastasis. C1 [Mitchell, L. A.] Tripler Army Med Ctr, MCHK DR, Dept Radiol, Honolulu, HI 96849 USA. [Kitley, C. A.; Krasnokutsky, M. V.] Madigan Army Med Ctr, Dept Radiol, Tacoma, WA 98431 USA. [Krasnokutsky, M. V.; Rooks, V. J.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. RP Mitchell, LA (reprint author), Tripler Army Med Ctr, MCHK DR, Dept Radiol, 1 Jarrett White Rd, Honolulu, HI 96849 USA. EM lex.a.mitchell@us.army.mil NR 19 TC 5 Z9 5 U1 0 U2 3 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 USA SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD NOV PY 2011 VL 32 IS 10 BP 1801 EP 1805 DI 10.3174/ajnr.A2673 PG 5 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 859PM UT WOS:000297888300008 PM 21920859 ER PT J AU Ocampo, J Millwater, H Singh, G Smith, H Abali, F Nuss, M Reyer, M Shiao, M AF Ocampo, J. Millwater, H. Singh, G. Smith, H. Abali, F. Nuss, M. Reyer, M. Shiao, M. TI Development of a Probabilistic Linear Damage Methodology for Small Aircraft SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT 51st AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference CY APR 10-15, 2010 CL Orlando, FL SP AIAA, AHS, ASME, ASC, ASCE, US Off Naval Res (ONR), US AF Off Sci Res AB A risk assessment evaluation of the continued operational safety of the general aviation fleet can provide important insight to the criticality/severity of a potentially serious structural issue. As such, the methodology and a computer code, SMARTILD, were developed to address risk assessment and risk management of general aviation structural issues. This information will provide a proactive approach to enable a nonbiased review of data to assure airworthiness. To address variability and uncertainties in loading and material properties, a probabilistic methodology was developed and implemented that considers the random loading and probabilistic stress-life material behavior developed from constant amplitude tests. The stress severity factor is used to account for the geometry effects (notches, fastener holes, etc.). Failure is determined using the Miner damage index with the index calibrated from simulations of variable amplitude tests. Monte Carlo sampling is used to calculate the structural probability of failure, or mean and standard deviation of flights and hours to failure, the hazard function, and sensitivity analysis. A numerical example is presented to demonstrate the methodology. C1 [Ocampo, J.; Millwater, H.; Singh, G.] Univ Texas San Antonio, San Antonio, TX 78249 USA. [Smith, H.] Boeing Co, St Louis, MO 63166 USA. [Abali, F.] FAA, Atlantic City, NJ 08405 USA. [Nuss, M.; Reyer, M.] FAA, Kansas City, MO 64106 USA. [Shiao, M.] USA, Res Lab, Aberdeen, MD 21001 USA. RP Ocampo, J (reprint author), Univ Texas San Antonio, San Antonio, TX 78249 USA. NR 15 TC 4 Z9 5 U1 0 U2 8 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD NOV-DEC PY 2011 VL 48 IS 6 BP 2090 EP 2106 DI 10.2514/1.C031463 PG 17 WC Engineering, Aerospace SC Engineering GA 860SE UT WOS:000297967200029 ER PT J AU Shamsuzzaman, M Singhasivanon, P Kaewkungwal, J Lawpoolsri, S Tangkijvanich, P Gibbons, RV Rahman, M Alamgir, ASM Mahtab, MA AF Shamsuzzaman, Md Singhasivanon, P. Kaewkungwal, J. Lawpoolsri, S. Tangkijvanich, P. Gibbons, Robert V. Rahman, M. Alamgir, A. S. M. Mahtab, M. A. TI HEPATITIS B AMONG PREGNANT WOMEN ATTENDING HEALTH CARE FACILITIES IN RURAL BANGLADESH SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH LA English DT Article DE hepatitis B; pregnant women; rural area; Bangladesh ID PREVALENCE AB This study assessed hepatitis B prevalence among pregnant women attending health care facilities in rural Bangladesh. Blood samples were collected from 480 participants. HBsAg was positive in 0.4% of subjects, anti-HBc was positive in 21.5% and anti-HBs was positive in 8.5% of subjects. HBsAg was more prevalent among the older age group. Hepatitis B has a low prevalence among pregnant women in rural Bangladesh. Existing hepatitis B vaccination schedule in the Expanded Program on Immunization (EPI) to vaccinate the children in rural Bangladesh is appropriate. C1 [Shamsuzzaman, Md; Singhasivanon, P.; Kaewkungwal, J.; Lawpoolsri, S.] Mahidol Univ, Fac Trop Med, Dept Trop Hyg, Bangkok 10400, Thailand. [Shamsuzzaman, Md] Directorate Gen Hlth Serv, Dhaka, Bangladesh. [Rahman, M.; Alamgir, A. S. M.] IEDCR, Dhaka, Bangladesh. [Mahtab, M. A.] Bangabandhu Seikh Mujib Med Univ, Dept Gastroenterol, Dhaka, Bangladesh. [Tangkijvanich, P.] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Shamsuzzaman, M (reprint author), Mahidol Univ, Fac Trop Med, Dept Trop Hyg, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand. EM zaman1217@yahoo.com FU World Health Organization FX We thank the staff of Upazila Health Complex and Smiling Sun Clinic, Gobindaganj, Gaibandha, Bangladesh for their help carrying out the study. Thanks also to the World Health Organization for providing financial support for this study. NR 15 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION PI BANGKOK PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND SN 0125-1562 J9 SE ASIAN J TROP MED JI Southeast Asian J. Trop. Med. Public Health PD NOV PY 2011 VL 42 IS 6 BP 1410 EP 1413 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine SC Public, Environmental & Occupational Health; Infectious Diseases; Tropical Medicine GA 859UO UT WOS:000297901500014 PM 22299410 ER PT J AU Ganio, MS Armstrong, LE Casa, DJ McDermott, BP Lee, EC Yamamoto, LM Marzano, S Lopez, RM Jimenez, L Le Bellego, L Chevillotte, E Lieberman, HR AF Ganio, Matthew S. Armstrong, Lawrence E. Casa, Douglas J. McDermott, Brendon P. Lee, Elaine C. Yamamoto, Linda M. Marzano, Stefania Lopez, Rebecca M. Jimenez, Liliana Le Bellego, Laurent Chevillotte, Emmanuel Lieberman, Harris R. TI Mild dehydration impairs cognitive performance and mood of men SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Vigilance; Reaction time; Reasoning; Memory; Furosemide ID EXERCISE-INDUCED DEHYDRATION; HEAT-STRESS; ENVIRONMENTAL-STRESS; HYPOBARIC HYPOXIA; VISUAL VIGILANCE; FLUID INGESTION; SLEEP LOSS; CAFFEINE; HYDRATION; WATER AB The present study assessed the effects of mild dehydration on cognitive performance and mood of young males. A total of twenty-six men (age 20.0 (SD 0.3) years) participated in three randomised, single-blind, repeated-measures trials: exercise-induced dehydration plus a diuretic (DD; 40 mg furosemide); exercise-induced dehydration plus placebo containing no diuretic (DN); exercise while maintaining euhydration plus placebo (EU; control condition). Each trial included three 40 min treadmill walks at 5.6 km/h, 5% grade in a 27.7 degrees C environment. A comprehensive computerised six-task cognitive test battery, the profile of mood states questionnaire and the symptom questionnaire (headache, concentration and task difficulty) were administered during each trial. Paired t tests compared the DD and DN trials resulting in >1% body mass loss (mean 1.59 (SD 0.42) %) with the volunteer's EU trial (0.01 (SD 0.03) %). Dehydration degraded specific aspects of cognitive performance: errors increased on visual vigilance (P=0.048) and visual working memory response latency slowed (P=0.021). Fatigue and tension/anxiety increased due to dehydration at rest (P=0.040 and 0.029) and fatigue during exercise (P=0.026). Plasma osmolality increased due to dehydration (P<0.001) but resting gastrointestinal temperature was not altered (P=0.238). In conclusion, mild dehydration without hyperthermia in men induced adverse changes in vigilance and working memory, and increased tension/anxiety and fatigue. C1 [Ganio, Matthew S.; Armstrong, Lawrence E.; Casa, Douglas J.; McDermott, Brendon P.; Lee, Elaine C.; Yamamoto, Linda M.; Marzano, Stefania; Lopez, Rebecca M.] Univ Connecticut, Human Performance Lab, Unit 1110, Storrs, CT 06269 USA. [Ganio, Matthew S.] Texas Hlth Presbyterian Hosp, Inst Exercise & Environm Med, Dallas, TX 75231 USA. [Jimenez, Liliana; Le Bellego, Laurent; Chevillotte, Emmanuel] Danone Res, R&D Waters, F-91767 Palaiseau, France. [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Armstrong, LE (reprint author), Univ Connecticut, Human Performance Lab, Unit 1110, Storrs, CT 06269 USA. EM lawrence.armstrong@uconn.edu OI Lopez, Rebecca/0000-0002-1340-8473 FU Danone Research, Palaiseau, France; Danone Waters Research Development FX The present study was supported by Danone Research, Palaiseau, France. The authors' contributions were as follows: L. E. A., D. J. C., L. J., L. L. B., E. C. and H. R. L. contributed to the study design; M. S. G., L. E. A., D. J. C., E. C. L., B. P. M., L. M. Y., S. M. and R. M. L. helped in data collection; M. S. G., L. E. A., E. C. L., S. M. and H. R. L. performed the data analysis; L. E. A., M. S. G. and H. R. L. were involved in writing of the manuscript; M. S. G., L. E. A., D. J. C., E. C. L., B. P. M., L. M. Y., S. M., R. M. L., L. J., L. L. B., E. C. and H. R. L. helped in editorial review of the manuscript. L. E. A. is a Danone Research Scientific Advisory Board member, paid consultant. L. J., L. L. B. and E. C. are employed by Danone Research. H. R. L. is currently a consultant to Danone Waters Research & Development but was not compensated by them for this project. M. S. G., D. J. C., E. C. L., B. P. M., L. M. Y., S. M., R. M. L. and H. R. L. declare no conflict of interest. The authors thank Dr Matthew Kramer for statistical assistance, and Lauren A. Thompson for technical assistance with manuscript revision and submission. The views, opinions and/or findings of the present study are those of the authors, and should not be construed as an official Department of the Army position, policy or decision, unless so designated by other official documentation. Citation of commercial organisation and trade names in the present study does not constitute an official Department of the Army endorsement or approval of the products or services of these organisations. Present affiliations are: B. P. M., Department of Health and Human Performance, University of Tennessee, Chattanooga, TN, USA; E. C. L., Mount Desert Island Biological Laboratory, Salisbury Cove, ME, USA; R. M. L., Department of Orthopaedics and Sports Medicine, University of South Florida, Tampa, USA. NR 40 TC 60 Z9 63 U1 2 U2 37 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0007-1145 J9 BRIT J NUTR JI Br. J. Nutr. PD NOV PY 2011 VL 106 IS 10 BP 1535 EP 1543 DI 10.1017/S0007114511002005 PG 9 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 855RQ UT WOS:000297582300011 PM 21736786 ER PT J AU Gao, ZZ Lai, HQ Liu, KJR AF Gao, Zhenzhen Lai, Hung-Quoc Liu, K. J. Ray TI Differential Space-Time Network Coding for Multi-Source Cooperative Communications SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Multinode cooperative communications; synchronization; channel estimation; space-time network coding; space-time-frequency network coding ID WIRELESS NETWORKS; FREQUENCY CODES; RELAY NETWORKS; BLOCK-CODES; DIVERSITY; MODULATION; PROTOCOLS; CHANNEL; DESIGN AB Due to the asynchronous nature of cooperative communications, simultaneous transmissions from two or more nodes are challenging in practice. The existing cooperative communications employing successive transmission from one user node to the other can avoid the synchronization problem but results in large transmission delay. In addition, channel estimation in multi-source cooperative communications is a challenging and costly task due to the amount of training, especially when the number of cooperative users is large. Considering these practical challenges in multi-source cooperative communications, this paper proposes a differential space-time network coding (DSTNC) scheme for narrowband multi-source cooperative communications to overcome the problems of imperfect synchronization and complex channel estimation without introducing large transmission delay. Each user in the network linearly combines the correctly decoded symbols via network coding and transmits its packet in time division multiple access (TDMA) mode. The pairwise error probability is analyzed and the design criteria of the DSTNC are derived to achieve full diversity. For broadband cooperative communications, distributed differential space-time-frequency network coding (DSTFNC), which is differentially encoded within each orthogonal frequency-division multiplexing (OFDM) block, is designed through mapping from the proposed DSTNC. When the statistical channel power-delay profile is known at the corresponding user node, each node can permutate its channel independently to improve the performance of the DSTFNC scheme. Simulation results are presented to verify the performance of the proposed schemes. C1 [Gao, Zhenzhen; Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Gao, Zhenzhen] Xi An Jiao Tong Univ, Sch Elect & Informat Engn, Xian 710049, Peoples R China. [Lai, Hung-Quoc] USA, RDECOM CERDEC, RDER STA DS, Aberdeen Proving Ground, MD 21005 USA. RP Gao, ZZ (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM ygggzhen@umd.edu; hungquoc.lai@us.army.mil; kjrliu@umd.edu NR 35 TC 10 Z9 12 U1 2 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 EI 1558-0857 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD NOV PY 2011 VL 59 IS 11 BP 3146 EP 3157 DI 10.1109/TCOMM.2011.082111.100694 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 855TX UT WOS:000297589000026 ER PT J AU Messaros, RC Bruno, MS AF Messaros, Roy C. Bruno, Michael S. TI Laboratory Investigation of Bedform Geometry under Regular and Irregular Surface Gravity Waves SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE Bedform geometry; ripple geometry; ripple height; ripple wavelength; bottom orbital excursion amplitude; sloped sediment bed ID RIPPLE GEOMETRY; MOVABLE BED; PREDICTION AB MESSAROS, R.C. and BRUNO, M.S., 2011. Laboratory investigation of bedform geometry under regular and irregular surface gravity waves. Journal of Coastal Research, 27(6A), 94-103. West Palm Beach (Florida), ISSN 0749-0208. Bedform (ripple) geometry is an important feature in the nearshore that can significantly enhance wave energy dissipation. Ripples regulate wave transformation and influence the sediment transport phenomenon. These issues are of particular importance when determining beach erosion and investigating other coastal processes. Although numerous studies have addressed the issue of bedform geometry under surface gravity waves, no single model is considered adequate. The relative roughness and subsequent wave energy dissipation are governed by attributes that include ripple height and wavelength. The comparatively large wave tank facility at Davidson Laboratory (Stevens Institute of Technology, Castle Point on the Hudson, Hoboken, New Jersey) provided an ideal opportunity for investigating bedform features for a flat bed, as well as the novel study of a sloped sediment bed. Our results provide new data that strengthen prior relationships and demonstrate that a sloped surface may be modeled in a similar fashion to a flat sediment bed. We have successfully compared irregular waves from the laboratory to field measurements and selected an existing model that is consistent with our data. Perhaps one of the most significant conclusions from this research is that the identified models for ripple dimensions on the flat surface predict values for bedform geometry on the sloped surface as well. C1 [Messaros, Roy C.] USA, Corps Engineers, New York, NY 10278 USA. [Bruno, Michael S.] Stevens Inst Technol, Hoboken, NJ 07030 USA. RP Messaros, RC (reprint author), USA, Corps Engineers, 26 Fed Plaza, New York, NY 10278 USA. EM roy.c.messaros@usace.army.mil NR 26 TC 0 Z9 0 U1 0 U2 1 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD NOV PY 2011 VL 27 IS 6A SU S BP 94 EP 103 DI 10.2112/JCOASTRES-D-09-00062.1 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA 851NT UT WOS:000297278500009 ER PT J AU Butler, S Gurvich, M Ghoshal, A Welsh, G Attridge, P Winston, H Urban, M Bordick, N AF Butler, Shaoluo Gurvich, Mark Ghoshal, Anindya Welsh, Gregory Attridge, Paul Winston, Howard Urban, Michael Bordick, Nathaniel TI Effect of embedded sensors on interlaminar damage in composite structures SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article DE Structural health monitoring (SHM); piezoelectric sensor (PZT); delamination; finite element analysis (FEA); composite structure ID PIEZOELECTRIC SENSOR/ACTUATOR NETWORK; PLATES; ACTUATORS AB This research focuses on developing an embedded sensor system to monitor the health of a composite rotor component. To support this objective, simulations were developed to investigate the impact of sensor insertions on local structural micro-mechanics and sensor responses. In particular, the potential side-effects (e. g., delamination onset and growth) of imbedding lead zirconate titanate (PZT) piezoelectric sensors in composite structures were studied. A modeling approach for evaluating interlaminar damage under the influence of embedded PZT sensors is proposed. The approach uses finite element cohesive zone models to describe interlaminar damage between plies or at ply ends. In addition, an embedded multi-ply PZT model was developed and integrated with the damage models. The approach presented in this paper analyzes the propagation of interlaminar damage in the vicinity of sensors and quantifies the effect of sensor presence on damage growth. A parametric study was performed to understand how damage zones, the size and geometry of resin pockets, and the locations and properties of PZT sensors affected interfacial strength. Damage behavior, under the influence of an embedded PZT sensor, was examined in specimens having a configuration similar to that of a selected rotating rotorcraft component. Finally, optimal locations of embedded PZT transducers were determined for the specimen under consideration. C1 [Ghoshal, Anindya] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Butler, Shaoluo; Gurvich, Mark; Welsh, Gregory; Attridge, Paul; Winston, Howard] United Technol Res Ctr, E Hartford, CT 06108 USA. [Urban, Michael] Sikorsky Aircraft Corp, Stratford, CT USA. [Bordick, Nathaniel] Army AATD, Ft Eustis, VA USA. RP Ghoshal, A (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM anindya.ghoshal.civ@mail.mil FU US Government [W911W6-08-2-0002] FX This research was partially funded by the US Government under Agreement No. W911W6-08-2-0002. The US Government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation thereon. NR 17 TC 8 Z9 8 U1 0 U2 4 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD NOV PY 2011 VL 22 IS 16 BP 1857 EP 1868 DI 10.1177/1045389X11414225 PG 12 WC Materials Science, Multidisciplinary SC Materials Science GA 855WQ UT WOS:000297597400007 ER PT J AU Grogan, BF Cranston, WC Lopez, DM Furbee, C Murray, CK Hsu, JR AF Grogan, Brian F. Cranston, William C. Lopez, Donna M. Furbee, Christopher Murray, Clinton K. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Do Protective Lead Garments Harbor Harmful Bacteria? SO ORTHOPEDICS LA English DT Article ID COMPUTER KEYBOARDS; CONTAMINATION; CARE AB This study attempted to identify and characterize bacteria present on shared-use protective lead shielding garments worn in the operating room. Those worn at the authors' institution were collected and swabbed in designated 5 x 5-cm areas. Swabs were sent to the clinical laboratory for bacterial isolation and identification. All isolates were identified using standard microbiological methods. Isolates then underwent antimicrobial susceptibility testing as per standard hospital procedures. Of 182 total collected swabs, bacteria were isolated on only 5 (2.7%) samples. Coagulase-negative Staphylococci was identified on 3 samples and the remaining 2 grew coagulase-negative Staphylococci and gram-positive rods. The collection sites for these isolates were the lead apron, midline, bottom outer surface (n = 3), thyroid shield midline, inner surface (n = 1), and skirt midline, bottom inner surface (n = 1). Of the collected samples, 98.3% were negative for bacterial growth. The remaining isolates were consistent with common skin flora. No multi-drug resistant organisms were identified on any garments. Standard cleaning procedures at the institution are an effective way to prevent growth of bacteria on shared-use protective lead shielding garments worn in the operating room. C1 [Grogan, Brian F.; Cranston, William C.] San Antonio Uniformed Serv Hlth Educ Consortium, Dept Orthopaed Surg, San Antonio Mil Med Consortium, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.] San Antonio Uniformed Serv Hlth Educ Consortium, Dept Med, San Antonio Mil Med Consortium, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Lopez, Donna M.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Furbee, Christopher] Gen Leonard Wood Army Community Hosp, Dept Orthopaed Surg, Wood, MO USA. RP Grogan, BF (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, Dept Orthopaed Surg, San Antonio Mil Med Consortium, Ft Sam Houston, TX 78234 USA. EM brian.grogan@us.army.mil RI Valle, Ruben/A-7512-2013 FU United States Army Institute of Surgical Research; Geneva Foundation FX This study was funded by the United States Army Institute of Surgical Research. Institutional research support was provided by the Geneva Foundation. NR 7 TC 3 Z9 3 U1 0 U2 3 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD NOV PY 2011 VL 34 IS 11 BP E765 EP E767 DI 10.3928/01477447-20110922-09 PG 3 WC Orthopedics SC Orthopedics GA 861RT UT WOS:000298037600012 PM 22049960 ER PT J AU Richard, M Morse, B Daly, SF Emond, J AF Richard, Martin Morse, Brian Daly, Steven F. Emond, Josee TI QUANTIFYING SUSPENDED FRAZIL ICE USING MULTI-FREQUENCY UNDERWATER ACOUSTIC DEVICES SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE frazil ice; multi-frequency; rise velocity; Rouse number; St. Lawrence River; supercooling; suspended concentration ID SOUND; WATER; FLUME AB An intensive frazil ice field sampling campaign was undertaken at the Port of Quebec on the St. Lawrence River from February-March 2009. Two underwater acoustic instruments set at different frequencies of 420 and 1228.8 kHz were used to detect frazil ice in the water column. In this paper, frequency inversion methods are presented and subsequently applied to the observations to estimate frazil ice characteristics and concentration. Using inversion methods, most of the detected ice crystals had estimated radii of 0.06-0.18 mm. This range compares favourably to the estimated value of 0.20mm obtained by analysing the Rouse number related to the vertical distribution of the frazil crystals. The results were in contrast to a previous study of frazil ice at another site in the St. Lawrence, which reported radii tens of times larger. The tiny crystals observed here were of similar size to those observed in laboratories (e. g. 0.09 mm), suggesting that the particles formed locally. Frequency analyses were also used to estimate the volumetric suspended frazil concentration, which appeared to be on the order of 6 ppm. Based on evidence suggested by the data and the volume backscattering coefficient at the two frequencies, this study also presents the complex sequence of processes that occurs during a typical supercooling frazil event. This paper concludes with future directions for research using acoustic instrumentation for further understanding of frazil ice dynamics. Copyright (C) 2010 John Wiley & Sons, Ltd. C1 [Richard, Martin; Morse, Brian; Emond, Josee] Univ Laval, Dept Civil Engn, Quebec City, PQ G1K 7P4, Canada. [Daly, Steven F.] USA, Cold Reg Res & Engn Lab, Erdc, Hanover, NH 03755 USA. RP Richard, M (reprint author), Univ Laval, Dept Civil Engn, Quebec City, PQ G1K 7P4, Canada. EM martin.richard.3@ulaval.ca FU Natural Sciences and Engineering Research Council of Canada (NSERC) FX The authors are grateful to Michel Petit of the Port of Quebec; Richard Doyon of Transport Canada; Edward Stander of the State University of New York (Cobleskill); Teledyne RD Instruments, Inc.; ASL Environmental Sciences; Martin Jasek of B. C. Hydro; Jean-Francois Lachance of Embarcations 4-saisons and our colleagues at Laval University. They also acknowledge the reviewers, whose careful review helped them improve this paper and text check who edited an earlier version of this document. The research was partially supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) discovery grant. NR 25 TC 6 Z9 6 U1 1 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD NOV PY 2011 VL 27 IS 9 SI SI BP 1106 EP 1117 DI 10.1002/rra.1446 PG 12 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 854RS UT WOS:000297512500004 ER PT J AU Sumner, JJ Chu, K AF Sumner, James J. Chu, Kevin TI Electrochemical Characterization of Riboflavin-Enhanced Reduction of Trinitrotoluene SO SENSORS LA English DT Article DE trinitrotoluene; dinitrotoluene; reduction; riboflavin; bioremediation; AC voltammetry ID FRESH-WATER ENVIRONMENT; 2,4,6-TRINITROTOLUENE TNT; ELECTROOXIDATIVE POLYMERIZATION; LIQUID-CHROMATOGRAPHY; ELECTRODE; 1,5-DIAMINONAPHTHALENE; DEGRADATION; NITRAMINE; SENSOR; SOIL AB There is great interest in understanding trinitrotoluene (TNT) and dinitrotoluene (DNT) contamination, detection and remediation in the environment due to TNT's negative health effects and security implications. Numerous publications have focused on detecting TNT in groundwater using multiple techniques, including electrochemistry. The main degradation pathway of nitrotoluenes in the environment is reduction, frequently with biological and/or photolytic assistance. Riboflavin has also been noted to aid in TNT remediation in soils and groundwater when exposed to light. This report indicates that adding riboflavin to a TNT or DNT solution enhances redox currents in electrochemical experiments. Here AC voltammetry was performed and peak currents compared with and without riboflavin present. Results indicated that TNT, DNT and riboflavin could be detected using AC voltammetry on modified gold electrodes and the addition of riboflavin affected redox peaks of TNT and DNT. Poised potential experiments indicated that it is possible to enhance reduction of TNT in the presence of riboflavin and light. These results were dramatic enough to explain long term enhancement of bioremediation in environments containing high levels of riboflavin and enhance the limit of detection in electrochemically-based nitrotoluene sensing. C1 [Sumner, James J.; Chu, Kevin] USA, Res Lab, RDRL SEE O, Adelphi, MD 20873 USA. [Chu, Kevin] Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA. RP Sumner, JJ (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20873 USA. EM james.j.sumner4.civ@mail.mil; kevin.chu.ctr@mail.mil FU US Army Research Laboratory, Sensors and Electron Devices Directorate (ARL-SEDD); Science and Engineering Apprenticeship Program (SEAP) FX The authors acknowledge R. G. Bozic, D. Chu and A. S. Finch for helpful conversations and advice as well as the support of the US Army Research Laboratory, Sensors and Electron Devices Directorate (ARL-SEDD). K. C. acknowledges the Science and Engineering Apprenticeship Program (SEAP) for support. NR 28 TC 2 Z9 2 U1 0 U2 24 PU MDPI AG PI BASEL PA POSTFACH, CH-4005 BASEL, SWITZERLAND SN 1424-8220 J9 SENSORS-BASEL JI Sensors PD NOV PY 2011 VL 11 IS 11 BP 10840 EP 10850 DI 10.3390/s111110840 PG 11 WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation SC Chemistry; Electrochemistry; Instruments & Instrumentation GA 857EK UT WOS:000297698600049 PM 22346674 ER PT J AU DeVine, JG AF DeVine, John G. TI Commentary: Standardization of dynamic lumbar imaging and diagnostic criteria for discogenic low back pain SO SPINE JOURNAL LA English DT Editorial Material ID TOTAL DISC REPLACEMENT; HIGH-INTENSITY ZONE; INVESTIGATIONAL DEVICE EXEMPTION; CHARITE(TM) ARTIFICIAL DISC; CLINICAL-OUTCOMES; MODIC CHANGES; DISCOGRAPHY; FUSION; ASSOCIATION; SPINE C1 Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, Ft Gordon, GA 30905 USA. RP DeVine, JG (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Orthopaed Surg, 300 E Hosp Rd, Ft Gordon, GA 30905 USA. EM john.devine@us.army.mil NR 23 TC 0 Z9 1 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD NOV PY 2011 VL 11 IS 11 BP 999 EP 1001 DI 10.1016/j.spinee.2011.10.018 PG 3 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 859GG UT WOS:000297864300002 PM 22122832 ER PT J AU Lehman, RA Kang, DG AF Lehman, Ronald A., Jr. Kang, Daniel G. TI Commentary: An increasing awareness of the complications after transpsoas lumbar interbody fusion procedure SO SPINE JOURNAL LA English DT Editorial Material ID MINIMALLY INVASIVE SURGERY; VERTEBRAL BODY OSTEOLYSIS; CONSTRUCTS; STRENGTH; OUTCOMES; BONE C1 [Lehman, Ronald A., Jr.; Kang, Daniel G.] Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Bethesda, MD 20889 USA. [Lehman, Ronald A., Jr.] Uniformed Serv Univ Hlth Sci, Dept Surg, Div Orthopaed, Bethesda, MD 20814 USA. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM armyspine@yahoo.com NR 17 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD NOV PY 2011 VL 11 IS 11 BP 1073 EP 1075 DI 10.1016/j.spinee.2011.10.020 PG 3 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 859GG UT WOS:000297864300013 PM 22122838 ER PT J AU Duysen, EG Koentgen, F Wiliams, GR Timperey, CM Schopfer, LM Cerasoli, DM Lockridge, O AF Duysen, Ellen G. Koentgen, Frank Wiliams, Gareth R. Timperey, Christopher M. Schopfer, Lawrence M. Cerasoli, Douglas M. Lockridge, Oksana TI Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID SOMAN PINACOLYL METHYLPHOSPHONOFLUORIDATE; HUMAN ACETYLCHOLINESTERASE; ORGANOPHOSPHORUS COMPOUNDS; ALBUMIN ESTERASE; STEREOISOMERS; MOUSE; CBDP; RAT; BUTYRYLCHOLINESTERASE; CHOLINESTERASE AB The LD(50) for soman is 10-20-fold higher for a mouse than a human. The difference in susceptibility is attributed to the presence of carboxylesterase in mouse but not in human plasma. Our goal was to make a mouse lacking plasma carboxylesterase. We used homologous recombination to inactivate the carboxylesterase ES1 gene on mouse chromosome 8 by deleting exon 5 and by introducing a frame shift for amino acids translated from exons 6 to 13. ES1-/- mice have no detectable carboxylesterase activity in plasma but have normal carboxylesterase activity in tissues. Homozygous ES1-/- mice and wild-type littermates were tested for response to a nerve agent model compound (soman coumarin) at 3 mg/kg sc. This dose intoxicated both genotypes but was lethal only to ES1-/- mice. This demonstrated that plasma carboxylesterase protects against a relatively high toxicity organophosphorus compound. The ES1-/- mouse should be an appropriate model for testing highly toxic nerve agents and for evaluating protection strategies against the toxicity of nerve agents. C1 [Duysen, Ellen G.; Schopfer, Lawrence M.; Lockridge, Oksana] Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE 68198 USA. [Koentgen, Frank] Ozgene Pty Ltd, Bentley Dc, WA 6983, Australia. [Wiliams, Gareth R.; Timperey, Christopher M.] Def Sci Technol Lab Dstl, Detect Dept, Salisbury SP4 OJQ, Wilts, England. [Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Physiol & Immunol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Lockridge, O (reprint author), Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE 68198 USA. EM olockrid@unmc.edu OI Duysen, Ellen/0000-0002-0128-9032 FU JSTO-Defense Threat Reduction Agency [I2_X005_04_RC_C, CBM.SCAV.01.10.RC.017]; National Institutes of Health through the National Institute of Neurological Disorders and Stroke [U01 NS058038] FX This work was supported in part by the JSTO-Defense Threat Reduction Agency under project numbers I2_X005_04_RC_C and CBM.SCAV.01.10.RC.017. Part of the work was funded by the National Institutes of Health CounterACT Program through the National Institute of Neurological Disorders and Stroke (Award #U01 NS058038). NR 32 TC 16 Z9 16 U1 3 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD NOV PY 2011 VL 24 IS 11 BP 1891 EP 1898 DI 10.1021/tx200237a PG 8 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 848VF UT WOS:000297082500013 PM 21875074 ER PT J AU Walker, EA Fenton, ME Salesky, JS Murphey, MD AF Walker, Eric A. Fenton, Michael E. Salesky, Joel S. Murphey, Mark D. TI Magnetic Resonance Imaging of Benign Soft Tissue Neoplasms in Adults SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Soft tissue tumor; Benign; MR imaging; Soft tissue neoplasm ID PIGMENTED VILLONODULAR SYNOVITIS; GIANT-CELL TUMOR; WELL-DIFFERENTIATED LIPOSARCOMA; LOCALIZED NODULAR SYNOVITIS; LARGE REFERRAL POPULATION; ABDOMINAL DESMOID TUMORS; SUBUNGUAL GLOMUS TUMORS; TENDON SHEATH; PLANTAR FIBROMATOSIS; PAROSTEAL LIPOMA AB This article reviews a spectrum of benign soft tissue tumors found in adults. Rather than presenting a complete review, the focus of this article is on benign tumors for which the diagnosis may be confidently made or strongly suggested on the basis of imaging. Diagnoses presented include nodular fasciitis, superficial and deep fibromatosis, elastofibroma, lipomatous lesions, giant cell tumor of the tendon sheath, pigmented villonodular synovitis, peripheral nerve sheath tumors, Morton neuroma, hemangioma, and myxoma. C1 [Walker, Eric A.] Penn State Univ, Milton S Hershey Med Ctr, Dept Radiol, Hershey, PA 17033 USA. [Walker, Eric A.; Murphey, Mark D.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD 20814 USA. [Fenton, Michael E.; Salesky, Joel S.; Murphey, Mark D.] Amer Inst Radiol Pathol, Silver Spring, MD 20910 USA. [Murphey, Mark D.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Walker, EA (reprint author), Penn State Univ, Milton S Hershey Med Ctr, Dept Radiol, H066,500 Univ Dr,POB 850, Hershey, PA 17033 USA. EM ewalker@hmc.psu.edu RI Walker, Eric/P-8862-2015 OI Walker, Eric/0000-0002-2353-5935 NR 146 TC 31 Z9 36 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0033-8389 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD NOV PY 2011 VL 49 IS 6 BP 1197 EP + DI 10.1016/j.rcl.2011.07.007 PG 22 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 853OT UT WOS:000297436300008 PM 22024295 ER PT J AU Walker, EA Salesky, JS Fenton, ME Murphey, MD AF Walker, Eric A. Salesky, Joel S. Fenton, Michael E. Murphey, Mark D. TI Magnetic Resonance Imaging of Malignant Soft Tissue Neoplasms in the Adult SO RADIOLOGIC CLINICS OF NORTH AMERICA LA English DT Article DE Soft tissue tumor; Malignant; MR imaging; Soft tissue neoplasm ID RADIOLOGIC-PATHOLOGICAL CORRELATION; NERVE SHEATH TUMORS; ROUND-CELL LIPOSARCOMA; WELL-DIFFERENTIATED LIPOSARCOMA; TOMOGRAPHY FDG-PET; SYNOVIAL SARCOMA; DERMATOFIBROSARCOMA PROTUBERANS; FIBROUS HISTIOCYTOMA; GADOPENTETATE DIMEGLUMINE; MUSCULOSKELETAL MASSES AB This review addresses the spectrum of malignant soft tissue tumors frequently found in adults. Rather than presenting a complete review, the focus of this discussion is on common lesions or lesions in which the diagnosis may be suggested on the basis of imaging. Diagnoses covered include undifferentiated high-grade pleomorphic sarcoma, fibrosarcoma, dermatofibrosarcoma protuberans, liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, clear cell sarcoma, hemangioendothelioma, hemangiopericytoma, angiosarcoma, and leiomyosarcoma. C1 [Walker, Eric A.] Penn State Univ, Milton S Hershey Med Ctr, Dept Radiol, Hershey, PA 17033 USA. [Walker, Eric A.; Murphey, Mark D.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD 20814 USA. [Salesky, Joel S.; Fenton, Michael E.; Murphey, Mark D.] Amer Inst Radiol Pathol, Silver Spring, MD 20910 USA. [Murphey, Mark D.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Walker, EA (reprint author), Penn State Univ, Milton S Hershey Med Ctr, Dept Radiol, H066,500 Univ Dr,POB 850, Hershey, PA 17033 USA. EM ewalker@hmc.psu.edu RI Walker, Eric/P-8862-2015 OI Walker, Eric/0000-0002-2353-5935 NR 100 TC 25 Z9 25 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0033-8389 J9 RADIOL CLIN N AM JI Radiol. Clin. N. Am. PD NOV PY 2011 VL 49 IS 6 BP 1219 EP + DI 10.1016/j.rcl.2011.07.006 PG 17 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 853OT UT WOS:000297436300009 PM 22024296 ER PT J AU Gordon, MS Kinlock, TW Miller, PM AF Gordon, Michael S. Kinlock, Timothy W. Miller, Patrice M. TI Medication-assisted Treatment Research with Criminal Justice Populations: Challenges of Implementation SO BEHAVIORAL SCIENCES & THE LAW LA English DT Article ID RANDOMIZED CLINICAL-TRIAL; METHADONE-MAINTENANCE; RELEASED PRISONERS; MONTHS POSTRELEASE; DEPENDENT PATIENTS; SUBSTANCE-ABUSE; FOLLOW-UP; DRUG-USE; BUPRENORPHINE; NALTREXONE AB Creating, implementing and evaluating substance abuse interventions, especially medication-assisted treatments, for prisoners, parolees, and probationers with histories of heroin addiction is an especially challenging endeavor because of the difficulty in coordinating and achieving cooperation among diverse criminal justice, substance abuse treatment, research, and social service agencies, each with its own priorities and agenda. In addition, there are special rules that must be followed when conducting research with criminal justice-involved populations, particularly prisoners. The following case studies will explore the authors' experience of over 10?years conducting pharmacotherapy research using methadone, buprenorphine, and naltrexone with criminal justice populations. The major obstacles and how they were overcome are presented. Finally, recommendations are provided with regard to implementing and conducting research with criminal justice populations. Copyright (c) 2011 John Wiley & Sons, Ltd. C1 [Gordon, Michael S.; Kinlock, Timothy W.] Friends Res Inst Inc, Baltimore, MD 21201 USA. [Gordon, Michael S.] Stevenson Univ, Dept Criminal Justice, Stevenson, MD 21153 USA. [Kinlock, Timothy W.] Univ Baltimore, Div Criminol Criminal Justice & Forens Studies, Baltimore, MD 21201 USA. [Miller, Patrice M.] USA, Subst Abuse Program, Ft George G Meade, MD USA. RP Gordon, MS (reprint author), Friends Res Inst Inc, 1040 Pk Ave,Suite 103, Baltimore, MD 21201 USA. EM mgordon@friendsresearch.org FU NIDA NIH HHS [R01 DA016237, R01 DA016237-05, R01 DA021579, R01 DA021579-05, R01 DA024550, R01 DA024550-05] NR 55 TC 11 Z9 11 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0735-3936 J9 BEHAV SCI LAW JI Behav. Sci. Law PD NOV-DEC PY 2011 VL 29 IS 6 SI SI BP 829 EP 845 DI 10.1002/bsl.1015 PG 17 WC Psychology, Applied; Law SC Psychology; Government & Law GA 849DR UT WOS:000297106300005 PM 22086665 ER PT J AU Liston, GE Hiemstra, CA AF Liston, Glen E. Hiemstra, Christopher A. TI The Changing Cryosphere: Pan-Arctic Snow Trends (1979-2009) SO JOURNAL OF CLIMATE LA English DT Article ID RECENT CLIMATE-CHANGE; SYNOPTICALLY FORCED HYDROCLIMATOLOGY; GENERAL-CIRCULATION MODELS; ANTARCTIC ICE-SHEET; KUPARUK RIVER-BASIN; NORTHERN-HEMISPHERE; GLOBAL PRECIPITATION; SOUTHEAST GREENLAND; COVER VARIABILITY; AMMASSALIK ISLAND AB Arctic snow presence, absence, properties, and water amount are key components of Earth's changing climate system that incur far-reaching physical and biological ramifications. Recent dataset and modeling developments permit relatively high-resolution (10-km horizontal grid; 3-11 time step) pan-Arctic snow estimates for 1979-2009. Using Micro Met and Snow Model in conjunction with land cover, topography, and 30 years of the NASA Modern-Era Retrospective Analysis for Research and Applications (MERRA) atmospheric reanalysis data, a distributed snow-related dataset was created including air temperature, snow precipitation, snow-season timing and length, maximum snow water equivalent (SWE) depth, average snow density, snow sublimation, and rain-on-snow events. Regional variability is a dominant feature of the modeled snow-property trends. Both positive and negative regional trends are distributed throughout the pan-Arctic domain, featuring, for example, spatially distinct areas of increasing and decreasing SWE or snow season length. In spite of strong regional variability, the data clearly show a general snow decrease throughout the Arctic: maximum winter SWE has decreased, snow-cover onset is later, the snow-free date in spring is earlier, and snow-cover duration has decreased. The domain-averaged air temperature trend when snow was on the ground was 0.17 degrees C decade(-1) with minimum and maximum regional trends of -0.55 degrees and 0.78 degrees C decade(-1), respectively. The trends for total number of snow days in a year averaged -2.49 days decade(-1) with minimum and maximum regional trends of -17.21 and 7.19 days decade(-1), respectively. The average trend for peak SWE in a snow season was -0.17 cm decade(-1) with minimum and maximum regional trends of -2.50 and 5.70 cm decade(-1), respectively. C1 [Liston, Glen E.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. [Hiemstra, Christopher A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Liston, GE (reprint author), Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA. EM liston@cira.colostate.edu FU NSF [0629279, 0632133]; NASA [NNX08AI03G] FX This work was supported by NSF Grants 0629279 and 0632133 and NASA Grant NNX08AI03G. The authors thank Matthew Sturm for his insightful contributions to the direction of this research, and Skip Walker and Jed Kaplan for their land-cover mapping discussions and advice. Andy Bunn, Matt Callihan, Kelly Elder, Sebastian Mernild, David Robinson, Drew Slater, John Strack, Sveta Stuefer, Matthew Sturm, Amy Tidwell, and two anonymous reviewers provided helpful comments on the manuscript. We would also like to thank the NASA Goddard Earth Sciences (GES) Data and Information Services Center (DISC) and Global Modeling and Assimilation Office (GMAO) for providing the MERRA datasets, NSIDC for providing the EASE-Grid weekly snow-cover extent and monthly SWE data, and NASA for providing the USAF/ETAC snow depth climatology data. NR 134 TC 70 Z9 72 U1 11 U2 60 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0894-8755 EI 1520-0442 J9 J CLIMATE JI J. Clim. PD NOV 1 PY 2011 VL 24 IS 21 BP 5691 EP 5712 DI 10.1175/JCLI-D-11-00081.1 PG 22 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 841TE UT WOS:000296535300016 ER PT J AU Johnson, JD O'Mara, HM Durtschi, HF Kopjar, B AF Johnson, Jeremy Daniel O'Mara, Heather M. Durtschi, Hyrum F. Kopjar, Branko TI Do Urine Cultures for Urinary Tract Infections Decrease Follow-up Visits? SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE Follow-up; Urine Cultures; Urinary Tract Infections ID GENERAL-PRACTICE; MANAGEMENT; CARE; WOMEN; STRATEGIES; RESISTANCE; CYSTITIS; DYSURIA; SERVICE; IMPACT AB Background: No major clinical practice guideline recommends ordering a urine culture in the management of uncomplicated urinary tract infections (UTIs). In this era of increasing antibiotic resistance, our objective was to determine if ordering urine cultures for adult women with uncomplicated UTIs provides results that lead to a decrease in follow-up visits for continued UTI symptoms. Methods: This was a retrospective cohort study from the outpatient family medicine clinic, Madigan Army Medical Center, Tacoma, WA. Seven hundred seventy-nine nondiabetic, nonpregnant, adult (aged 18-65 years) female patients (mean age +/- SD, 32.9 +/- 12.1 years) diagnosed with a UTI from November 2006 through March 2008. The main outcome measure was follow-up outpatient visits within 2 weeks for recurrent UTI symptoms. Results: Of the 779 patients studied, 332 (43%) had no urine culture ordered as part of their management and 447 (57%) had a urine culture ordered. There was no significant difference in the rate of follow-up within 2 weeks for continued UTI symptoms between the cohort without urine culture (28 of 332; 8.4%) and the cohort with urine culture (39 of 447; 8.7%) (chi(2) = 0.021; P = .89). In multivariate logistic regression, ordering a urine culture was not associated with a decreased rate of follow-up visits (adjusted odds ratio, 1.11; 95% CI, 0.65-1.90). Conclusions: In adult women with uncomplicated UTI, ordering a urine culture was not found to be associated with a decrease in follow-up clinic visits. This finding is consistent with current guidelines that recommend against ordering a urine culture for uncomplicated UTIs. (J Am Board Fam Med 2011; 24: 647-655.) C1 [Johnson, Jeremy Daniel] Attn MCHK FMR, Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96734 USA. [O'Mara, Heather M.] 82nd Airborne Div, Brigade Combat Team 2, Ft Bragg, NC USA. [Durtschi, Hyrum F.] Grafenwoehr Army Hlth Clin, Grafenwoehr, Germany. [Kopjar, Branko] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA. RP Johnson, JD (reprint author), Attn MCHK FMR, Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96734 USA. EM jeremy.daniel.johnson@us.army.mil FU United States Army FX Financial and material support provided by the United States Army. NR 31 TC 3 Z9 3 U1 0 U2 2 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD NOV-DEC PY 2011 VL 24 IS 6 BP 647 EP 655 DI 10.3122/jabfm.2011.06.100299 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 849UI UT WOS:000297150400008 PM 22086807 ER PT J AU Hazin, R Coyer, M Lum, F Barazi, MK AF Hazin, Ribhi Coyer, Marcus Lum, Flora Barazi, Mohammed K. TI Revisiting Diabetes 2000: Challenges in Establishing Nationwide Diabetic Retinopathy Prevention Programs SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Editorial Material ID NUTRITION EXAMINATION SURVEY; PREFERRED PRACTICE PATTERN; IMPAIRED FASTING GLUCOSE; TREATING RETINOPATHY; US POPULATION; UNITED-STATES; RISK-FACTORS; EYE DISEASE; FOLLOW-UP; MELLITUS AB PURPOSE: To evaluate the impact of the Diabetes 2000 program, an initiative launched by the American Academy of Ophthalmology in 1990 to improve nationwide screening of diabetic retinopathy (DR) and to reduce the prevalence and severity of the condition. DESIGN: Retrospective, observational case study of Diabetes 2000 program. METHODS: This is a perspective piece with a review of literature and personal opinions. RESULTS: Patients with diabetes are likely to see an increase in the disease burdens associated with DR unless effective programs for early detection and control of DR are implemented. CONCLUSIONS: Despite recent efforts to educate both patients and physicians alike about the importance of routine DR screening, the lessons learned from the Diabetes 2000 program illustrate the need for new strategies capable of improving accessibility to high-quality eye care, increasing involvement of primary care physicians in DR screening and encouraging at-risk individuals to seek testing. (Am J Ophthalmol 2011; 152:723-729. (C) 2011 by Elsevier Inc. All rights reserved.) C1 [Hazin, Ribhi] Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, Boston, MA 02138 USA. [Coyer, Marcus; Barazi, Mohammed K.] Retina Grp Washington, Manassas, VA USA. [Coyer, Marcus] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Lum, Flora] Amer Acad Ophthalmol, San Francisco, CA USA. RP Hazin, R (reprint author), Harvard Univ, Sch Med, Massachusetts Eye & Ear Infirm, 243 Charles St, Boston, MA 02138 USA. EM rhazin@mail.harvard.edu NR 49 TC 16 Z9 16 U1 1 U2 12 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 EI 1879-1891 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD NOV PY 2011 VL 152 IS 5 BP 723 EP 729 DI 10.1016/j.ajo.2011.06.022 PG 7 WC Ophthalmology SC Ophthalmology GA 840BK UT WOS:000296413100004 PM 21917235 ER PT J AU Robertson, BD McCoy, RL Nelson, MR Haymore, BR AF Robertson, Brian D. McCoy, Robert L. Nelson, Michael R. Haymore, Bret R. TI Effect of allergen immunotherapy practice parameters on cat extract prescribing patterns, 1993-2009 SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Article ID DOUBLE-BLIND PLACEBO; DOG-DANDER EXTRACTS; EFFICACY; ASTHMA AB Background: Cat extract allergen immunotherapy (AIT) is an effective treatment for cat allergy. The prescribed dose for cat AIT varies among prescribers, despite published data supporting an effective dose range. The original practice parameter published in December 1996 did not recommend a dose of cat allergen, but updates in January 2003 and September 2007 recommend cat extract dose ranges of 2,000 to 3,000 BAU and 1,000 to 4,000 BAU, respectively. Objective: To describe the prescribing patterns for cat AIT among practicing allergists in a large health care system and the effect of practice parameters on these patterns. Methods: A total of 27,788 prescriptions were analyzed to determine the date and amount of maintenance dose cat allergen prescribed. The data were subdivided into periods before and after the 3 published AIT practice parameters. Results: From January 2003 to September 2007, 1,810 prescriptions (18.0%) were written in the recommended range. From September 2007 to May 2009, 3,143 prescriptions (82.6%) were written in the recommended range. Cat AIT maintenance doses were 1,000 to 4,000 BAU 22.1% of the time before January 2003, 61.8% from January 2003 to September 2007, and 82.6% from September 2007 to May 2009. Conclusions: In this large systemic evaluation of cat AIT prescribing patterns, maintenance dose recommendations in the AIT practice parameters were associated with changes in the prescribing patterns for cat AIT. Most prescriptions for cat AIT were inconsistent with recommended doses in the AIT practice parameters between 2003 and 2007. Dosing within recommended ranges improved after 2007, in part due to a widening of the recommended dose range. Ann Allergy Asthma Immunol. 2011;107:437-440. C1 [Robertson, Brian D.] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. RP Robertson, BD (reprint author), Walter Reed Army Med Ctr, Dept Allergy Immunol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM brian.robertson@amedd.army.mil NR 20 TC 4 Z9 4 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD NOV PY 2011 VL 107 IS 5 BP 437 EP 440 DI 10.1016/j.anai.2011.06.012 PG 4 WC Allergy; Immunology SC Allergy; Immunology GA 845LZ UT WOS:000296825500010 PM 22018616 ER PT J AU Sarici, AM Shah, SU Shields, CL Birdsong, RH Shields, JA AF Sarici, Ahmet M. Shah, Sanket U. Shields, Carol L. Birdsong, Richard H. Shields, Jerry A. TI Cutaneous Halo Nevi Following Plaque Radiotherapy for Uveal Melanoma SO ARCHIVES OF OPHTHALMOLOGY LA English DT Letter ID VITILIGO C1 [Sarici, Ahmet M.; Shah, Sanket U.; Shields, Carol L.; Shields, Jerry A.] Thomas Jefferson Univ, Dept Ocular Oncol, Wills Eye Inst, Philadelphia, PA 19107 USA. [Birdsong, Richard H.] Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. RP Shields, CL (reprint author), Thomas Jefferson Univ, Dept Ocular Oncol, Wills Eye Inst, 840 Walnut St,Ste 1440, Philadelphia, PA 19107 USA. EM carol.shields@shieldsoncology.com NR 8 TC 4 Z9 4 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD NOV PY 2011 VL 129 IS 11 BP 1499 EP 1501 PG 4 WC Ophthalmology SC Ophthalmology GA 848JK UT WOS:000297047600020 PM 22084224 ER PT J AU Figueiredo, TH Aroniadou-Anderjaska, V Qashu, F Apland, JP Pidoplichko, V Stevens, D Ferrara, TM Braga, MFM AF Figueiredo, T. H. Aroniadou-Anderjaska, V. Qashu, F. Apland, J. P. Pidoplichko, V. Stevens, D. Ferrara, T. M. Braga, M. F. M. TI Neuroprotective efficacy of caramiphen against soman and mechanisms of its action SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Article DE caramiphen; nerve agents; soman; neuropathology; neurodegeneration; NMDA receptors; GABA(A) receptors; GABAergic inhibition; anticonvulsants; neuroprotectants ID HIPPOCAMPAL PYRAMIDAL NEURONS; ORGANOPHOSPHORUS NERVE AGENTS; SARIN-INDUCED SEIZURES; INDUCED BRAIN-DAMAGE; SIGMA-SITE LIGANDS; NONOPIOID ANTITUSSIVES; ANTICONVULSANT TREATMENT; ANTICHOLINERGIC DRUGS; COGNITIVE DYSFUNCTION; EPILEPTIFORM ACTIVITY AB BACKGROUND AND PURPOSE Caramiphen is a muscarinic antagonist with potent anticonvulsant properties. Here, we investigated the efficacy of caramiphen against behavioural seizures and neuropathology induced by the nerve agent soman, and revealed two mechanisms that may underlie the anticonvulsant efficacy of caramiphen. EXPERIMENTAL APPROACH Rats were given caramiphen at 30 or 60 min after treatment with soman. Neuronal loss in the basolateral amygdala (BLA) and neuronal degeneration in the amygdala, hippocampus, piriform cortex, entorhinal cortex and neocortex, were investigated 24 h after soman, using design-based stereology and FluoroJade-C staining. The effects of caramiphen on NMDA-, AMPA- and GABA-evoked currents were studied in the BLA region of in vitro brain slices from un-treated rats, using whole-cell recordings. KEY RESULTS Caramiphen given either 30 min or 60 min after soman, suppressed behavioural seizures within 10 min, but required 1 similar to 4.5 h for complete cessation of seizures. Neuronal loss and degeneration were significantly reduced in the caramiphen-treated, soman-exposed rats. Postsynaptic currents evoked by puff-application of NMDA on BLA principal cells were reduced by caramiphen in a dose-dependent manner (100 mu M, 300 mu M and 1 mM), while GABA-evoked currents were facilitated by 100 mu M and 300 mu M, but depressed by 1 mM caramiphen. AMPA-evoked currents were not affected by caramiphen. CONCLUSIONS AND IMPLICATIONS Caramiphen offered partial protection against soman-induced seizures and neuropathology, even when given 60 min after soman. NMDA receptor antagonism and facilitation of GABAergic inhibition in the BLA may play a key role in the anticonvulsive and neuroprotective properties of caramiphen. C1 [Figueiredo, T. H.; Aroniadou-Anderjaska, V.; Qashu, F.; Pidoplichko, V.; Stevens, D.; Braga, M. F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Aroniadou-Anderjaska, V.; Braga, M. F. M.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. [Apland, J. P.; Ferrara, T. M.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, F Edward Hebert Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mbraga@usuhs.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [1.E0021_07_US_C]; National Institutes of Health Office of the Director through the National Institute of Neurological Disorders and Stroke [U01 NS058162-01] FX This work was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (grant # 1.E0021_07_US_C), and the CounterACT Program, National Institutes of Health Office of the Director through the National Institute of Neurological Disorders and Stroke (award # U01 NS058162-01). NR 44 TC 21 Z9 21 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD NOV PY 2011 VL 164 IS 5 BP 1495 EP 1505 DI 10.1111/j.1476-5381.2011.01427.x PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 840WK UT WOS:000296472300011 PM 21486285 ER PT J AU Deweber, K Lynch, JH AF deWeber, Kevin Lynch, James H. TI Sideline Acupuncture for Acute Pain Control: A Case Series SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID AURICULAR ACUPUNCTURE; CANCER PAIN C1 [deWeber, Kevin] Uniformed Serv Univ Hlth Sci, Dept FAP, Bethesda, MD 20814 USA. [Lynch, James H.] USA, Med Corps, Ft Bragg, NC USA. RP Deweber, K (reprint author), Uniformed Serv Univ Hlth Sci, Dept FAP, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM kdeweber@usuhs.mil NR 10 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD NOV-DEC PY 2011 VL 10 IS 6 BP 320 EP 323 DI 10.1249/JSR.0b013e318237be0f PG 4 WC Sport Sciences SC Sport Sciences GA 845XB UT WOS:000296859400004 PM 22071391 ER PT J AU Bergeron, MF Nindl, BC Deuster, PA Baumgartner, N Kane, SF Kraemer, WJ Sexauer, LR Thompson, WR O'Connor, FG AF Bergeron, Michael F. Nindl, Bradley C. Deuster, Patricia A. Baumgartner, Neal Kane, Shawn F. Kraemer, William J. Sexauer, Lisa R. Thompson, Walter R. O'Connor, Francis G. TI Consortium for Health and Military Performance and American College of Sports Medicine Consensus Paper on Extreme Conditioning Programs in Military Personnel SO CURRENT SPORTS MEDICINE REPORTS LA English DT Review ID SICKLE-CELL TRAIT; PHYSICAL-ACTIVITY; EXERCISE; RHABDOMYOLYSIS; PREVENTION; INJURIES; FATIGUE; STRESS; RETURN AB A potential emerging problem associated with increasingly popularized extreme conditioning programs (ECPs) has been identified by the military and civilian communities. That is, there is an apparent disproportionate musculoskeletal injury risk from these demanding programs, particularly for novice participants, resulting in lost duty time, medical treatment, and extensive rehabilitation. This is a significant and costly concern for the military with regard to effectively maintaining operational readiness of the Force. While there are certain recognized positive aspects of ECPs that address a perceived and/or actual unfulfilled conditioning need for many individuals and military units, these programs have limitations and should be considered carefully. Moreover, certain distinctive characteristics of ECPs appear to violate recognized accepted standards for safely and appropriately developing muscular fitness and are not uniformly aligned with established and accepted training doctrine. Accordingly, practical solutions to improve ECP prescription and implementation and reduce injury risk are of paramount importance. C1 [Bergeron, Michael F.] Sanford USD Med Ctr, Natl Inst Athlet Hlth & Performance, Sioux Falls, SD 57104 USA. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [O'Connor, Francis G.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Baumgartner, Neal] HQ AETC A3TH, AETC Force Fitness, Randolph Air Force Base, TX USA. [Kane, Shawn F.] Family Sports Med, Ft Bragg, NC USA. [Kraemer, William J.] Univ Connecticut, Human Performance Lab, Dept Kinesiol, Unit 1110, Storrs, CT USA. [Sexauer, Lisa R.] USN, Installat Command, Washington, DC USA. [Thompson, Walter R.] Georgia State Univ, Dept Kinesiol & Hlth, Atlanta, GA 30303 USA. RP Bergeron, MF (reprint author), Sanford USD Med Ctr, Natl Inst Athlet Hlth & Performance, 1210 W 18th St,Suite 204, Sioux Falls, SD 57104 USA. EM michael.bergeron@sanfordhealth.org RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 FU USU-CHAMP; ACSM FX The authors acknowledge that the DoD-ACSM workshop involved more than 50 professionals including not only speakers and the writing group but also experts and other guests from both the military and civilian sports medicine and training communities. A special thanks to Mr. James R. Whitehead, ACSM Executive Vice President/CEO, as well as conference coordinators Ms. Jane Senior, ACSM Assistant Executive Vice President, Research Administration and Programs, Ms. Stephanie Garwood, ACSM Meetings Manager, and Stacey Zeno, Program Manager, CHAMP, USU. This DoD-ACSM workshop was made possible by educational support from the USU-CHAMP and ACSM. NR 27 TC 24 Z9 24 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1537-890X J9 CURR SPORT MED REP JI Curr. Sport. Med. Rep. PD NOV-DEC PY 2011 VL 10 IS 6 BP 383 EP 389 DI 10.1249/JSR.0b013e318237bf8a PG 7 WC Sport Sciences SC Sport Sciences GA 845XB UT WOS:000296859400013 PM 22071400 ER PT J AU Kish, LB Chang, HC King, MD Kwan, C Jensen, JO Schmera, G Smulko, J Gingl, Z Granqvist, CG AF Kish, Laszlo B. Chang, Hung C. King, Maria D. Kwan, Chiman Jensen, James O. Schmera, Gabor Smulko, Janusz Gingl, Zoltan Granqvist, Claes G. TI Fluctuation-Enhanced Sensing for Biological Agent Detection and Identification SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE Bacterium identification; biological sensing; fluctuation-enhanced sensing (FES); spore identification; stochastic signals ID GAS SENSORS; NOISE; SPECTRA AB We survey and show our earlier results about three different ways of fluctuation-enhanced sensing of bio agent, 1) the phage-based method for bacterium detection published earlier; 2) sensing and evaluating the odors of microbes; and 3) spectral and amplitude distribution analysis of noise in light scattering to identify spores based on their diffusion coefficient. C1 [Kish, Laszlo B.; Chang, Hung C.] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. [King, Maria D.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. [Kwan, Chiman] Signal Proc Inc, Rockville, MD 20850 USA. [Jensen, James O.] USA, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Edgewood, MD 21040 USA. [Schmera, Gabor] Space & Naval Warfare Syst Ctr, San Diego, CA 92152 USA. [Smulko, Janusz] Gdansk Univ Technol, PL-80952 Gdansk, Poland. [Gingl, Zoltan] Univ Szeged, Dept Expt Phys, H-6720 Szeged, Hungary. [Granqvist, Claes G.] Uppsala Univ, Angstrom Lab, SE-75121 Uppsala, Sweden. RP Kish, LB (reprint author), Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. EM laszlo@ece.tamu.edu; hungchih@neo.tamu.edu; mdking@neo.tamu.edu; chiman.kwan@signalpro.net; jim.jensen@us.army.mil; schmera@spawar.navy.mil; jsmulko@eti.pg.gda.pl; gingl@physx.u-szeged.hu; claes-goran.granqvist@angstrom.uu.se RI Gingl, Zoltan/E-8262-2011; Smulko, Janusz/P-6814-2014 OI Gingl, Zoltan/0000-0001-6570-2685; Smulko, Janusz/0000-0003-1459-4199 FU Army Research Office [W911NF-08-C-0031] FX This work was supported in part by the Army Research Office under Contract W911NF-08-C-0031. The review of this paper was arranged by Associate Editor D. L. Woolard. NR 26 TC 6 Z9 6 U1 1 U2 13 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD NOV PY 2011 VL 10 IS 6 BP 1238 EP 1242 DI 10.1109/TNANO.2011.2105277 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 844JA UT WOS:000296742300007 ER PT J AU Kallstrom, G Chang, T Albertson, M Morilla, D Fisher, MA Eberly, B AF Kallstrom, George Chang, Tom Albertson, Marc Morilla, Daniel Fisher, Mark A. Eberly, Bardwell TI Recovery of a Catalase-Negative Staphylococcus epidermidis Strain in Blood and Urine Cultures from a Patient with Pyelonephritis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID AUREUS STRAIN; ANAEROBIUS; MUTATIONS; SUBSP; GENE AB This report describes a 60-year-old patient with bilateral nephrolithiasis. A catalase-negative Staphylococcus epidermidis strain was recovered from both urine and blood cultures. Although rare, isolates of catalase-negative Staphylococcus spp., including Staphylococcus aureus, have been reported. Here, we describe the first report of a catalase-negative S. epidermidis strain. C1 [Kallstrom, George] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. [Fisher, Mark A.] ARUP Labs, Salt Lake City, UT USA. RP Kallstrom, G (reprint author), Tripler Army Med Ctr, Dept Pathol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM george.kallstrom@us.army.mil NR 6 TC 3 Z9 3 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD NOV PY 2011 VL 49 IS 11 BP 4018 EP 4019 DI 10.1128/JCM.01031-11 PG 2 WC Microbiology SC Microbiology GA 842RM UT WOS:000296617300057 PM 21900516 ER PT J AU Naylor, J Mines, P Anderson, A Kwon, D AF Naylor, Justin Mines, Pete Anderson, Alfred Kwon, David TI The Use of Guided Tissue Regeneration Techniques among Endodontists: A Web-based Survey SO JOURNAL OF ENDODONTICS LA English DT Article DE Endodontic surgery; guided tissue regeneration; root-end surgery ID PERIRADICULAR SURGERY; LESIONS; MEMBRANE; MANAGEMENT AB Introduction: The purpose of this study was to determine factors and clinical situations that influence an endodontist's decision to use guided tissue regeneration (GTR) techniques during endodontic root-end surgery. Methods: An invitation to participate in a web-based survey was e-mailed to 3,750 members of the American Association of Endodontists. Data were collected from 1,129 participants, representing a 30.1% completion rate. The number of questions varied from 3 to 11 depending on individual responses. Results: 40.7% of respondents who perform root-end surgeries also use GTR techniques. The clinical situation in which GTR techniques are used most often is for transosseous lesions. Barrier membranes and bone replacement grafts are each used by more than 85% of respondents using GTR techniques. Insufficient training and insufficient evidence in support of its use were selected as the predominant reasons for not using GTR techniques at 42.4% and 32%, respectively. Conclusions: Although over 40% of respondents are currently using GTR techniques in conjunction with their root-end surgeries, a majority of those who do not use GTR indicated they would consider using these techniques with better evidence and available training. (J Endod 2011;37: 1495-1498) C1 [Naylor, Justin; Mines, Pete; Anderson, Alfred; Kwon, David] USA, Endodont Residency Program, Ft Bragg, NC USA. RP Naylor, J (reprint author), Bldg D3836 Ardennes Rd, Ft Bragg, NC 28310 USA. EM justin.naylor@us.army.mil NR 20 TC 3 Z9 4 U1 1 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0099-2399 J9 J ENDODONT JI J. Endod. PD NOV PY 2011 VL 37 IS 11 BP 1495 EP 1498 DI 10.1016/j.joen.2011.08.017 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 847AM UT WOS:000296944300002 PM 22000450 ER PT J AU Fresconi, F AF Fresconi, Frank TI Guidance and Control of a Projectile with Reduced Sensor and Actuator Requirements SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article ID GUIDED PROJECTILE; CONTROL MECHANISM; ROCKET; DESIGN AB Successfully guiding a projectile launched from a gun is an extremely challenging task. Striking a balance between performance and affordability requires innovative solutions. This paper introduces a unique guidance and control strategy that enables precision and trajectory shaping with reduced Sensor and actuator needs. The derivation of this guidance and control algorithm is based on flight dynamics. Flight experiments were conducted to verify that the algorithm guided the projectile to the target and to demonstrate its application to different airframes. Features of the algorithm (such as expected precision, maneuver conservation, and trajectory shaping) were investigated through modeling and simulation. Position bias errors drove the precision; errors due to the guidance and control algorithm were on the order of 0.1 m. An analysis was conducted on the lateral acceleration available from the airframe, lateral acceleration required for this algorithm, and lateral acceleration required for classic proportional navigation. For control-authority-limited munitions proportional navigation was unable to intercept the target point, whereas the current guidance algorithm successfully hit the target. Trajectory shaping with this algorithm is demonstrated through simulation. C1 USA, Res Lab, Precis & Guided Flight Dynam Team, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21015 USA. RP Fresconi, F (reprint author), USA, Res Lab, Precis & Guided Flight Dynam Team, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21015 USA. NR 25 TC 26 Z9 27 U1 4 U2 11 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD NOV-DEC PY 2011 VL 34 IS 6 BP 1757 EP 1766 DI 10.2514/1.53584 PG 10 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 845LT UT WOS:000296824900014 ER PT J AU Britch, SC Linthicum, KJ Walker, TW Farooq, M Gordon, SW Clark, JW Ngere, F Ngonga, D Chepchieng, C AF Britch, Seth C. Linthicum, Kenneth J. Walker, Todd W. Farooq, Muhammad Gordon, Scott W. Clark, Jeffrey W. Ngere, Francis Ngonga, Daniel Chepchieng, Clifford TI Evaluation of ULV Applications Against Old World Sand Fly (Diptera: Psychodidae) Species in Equatorial Kenya SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Marigat; Kenya; phlebotomine sand fly; Fyfanon; Duet; Deployed War Fighter Protection Program ID BARINGO DISTRICT; VECTOR CONTROL; CUTANEOUS LEISHMANIASIS; PHLEBOTOMINE SANDFLIES; BARRIER TREATMENTS; MOSQUITO-CONTROL; ANIMAL BURROWS; INSECTICIDES; MILITARY; MARIGAT AB Reducing populations of phlebotomine sand flies in areas prevalent for human leishmaniases is of ongoing importance to United States military operations and civilian populations in endemic regions. However, not enough is known regarding the efficacy of Department of Defense-approved pesticides and equipment against sand flies; specifically, the potential for ultra-low volume (ULV) pesticide applications to control Old World sand fly vectors. In this study we examine two sprayers, the Terminator ULV and the Grizzly ULV, with UV-labeled Duet and Fyfanon in four combinations against caged Phlebotomus duboscqi (Neveu-Lemaire) and wild sand fly populations in a natural environment in western Kenya. All equipment and Fyfanon have United States military National Stock Numbers and both pesticides are registered with the United States Environmental Protection Agency. Caged sand flies were reared from local P. duboscqi and the area has long been studied because of high incidences of human cutaneous and visceral Leishmania. Patterns of mortality across grids of caged sand flies showed greater efficacy from the Grizzly ULV regardless of chemical. The Terminator ULV performed well with Duet but with a less uniform and overall lower rate of mortality across the spray grid. Sampling of wild populations before and after treatments suggested local population suppression from ULV treatments, as well as a possible repellent effect in nearby untreated areas. Surprisingly, ULV active ingredient deposition inferred from patterns of UV-labeled droplets captured on cotton ribbons adjacent to sand fly cages in spray plots did not match patterns of mortality. We discuss the implications of this study, the first of its kind, for future military preventive medicine activities, including relative performance costs and benefits of larger or smaller sprayers, and the relative stability of ULV-induced mortality patterns in varied or sub-optimal conditions. C1 [Britch, Seth C.; Linthicum, Kenneth J.] ARS, USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA. [Walker, Todd W.; Farooq, Muhammad] USN, Navy Entomol Ctr Excellence, Air Stn, Jacksonville, FL 32212 USA. [Gordon, Scott W.; Clark, Jeffrey W.; Ngere, Francis; Ngonga, Daniel; Chepchieng, Clifford] USA, Med Res Unit Kenya, Unit 64109, Dpo, AE 09831 USA. RP Britch, SC (reprint author), ARS, USDA, Ctr Med Agr & Vet Entomol, 1600 SW 23rd Dr, Gainesville, FL 32608 USA. EM seth.britch@ars.usda.gov FU Department of Defense (DoD); U.S. Department of Agriculture (USDA)-Agricultural Research Service; U.S. Army Medical Research Unit-Kenya (USAMRU-K) FX This research was supported by the Department of Defense (DoD) through the Deployed War Fighter Protection Program, and the U.S. Department of Agriculture (USDA)-Agricultural Research Service. The Grizzly ULV and Duet were kindly provided by Clarke Mosquito Control, Inc.; Mention of trade names or commercial products in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the U.S. Department of Agriculture, the DoD, the U.S. Navy, or the U.S. Army. Technicians from the U.S. Army Medical Research Unit-Kenya (USAMRU-K) provided expert assistance and support in the field. USDA is an equal opportunity provider and employer. NR 37 TC 9 Z9 9 U1 1 U2 2 PU ENTOMOLOGICAL SOC AMER PI ANNAPOLIS PA 3 PARK PLACE, STE 307, ANNAPOLIS, MD 21401-3722 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2011 VL 48 IS 6 BP 1145 EP 1159 DI 10.1603/ME11025 PG 15 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 849QK UT WOS:000297140000007 PM 22238873 ER PT J AU Lutomiah, JL Koka, H Mutisya, J Yalwala, S Muthoni, M Makio, A Limbaso, S Musila, L Clark, JW Turell, MJ Kioko, E Schnabel, D Sang, RC AF Lutomiah, Joel L. Koka, Hellen Mutisya, James Yalwala, Santos Muthoni, Milka Makio, Albina Limbaso, Samson Musila, Lillian Clark, Jeffrey W. Turell, Michael J. Kioko, Elizabeth Schnabel, David Sang, Rosemary C. TI Ability of Selected Kenyan Mosquito (Diptera: Culicidae) Species to Transmit West Nile Virus Under Laboratory Conditions SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Kenya; transmission; vector competence ID RIFT-VALLEY-FEVER; VECTOR COMPETENCE; CULEX-UNIVITTATUS; SINDBIS VIRUSES; DISSEMINATION; DISEASE; PIPIENS AB West Nile virus (WNV) is currently active in Kenya as evidenced by the detection of antibodies in birds bled as part of an avian influenza surveillance program in 2009. Although WNV has been isolated from several mosquito species in Kenya, no studies have ever been conducted to determine which of these species are competent vectors of this virus. Therefore, we allowed Kenyan mosquitoes to feed on 2- or 3-d-old chickens that had been infected with a Lineage one strain of WNV 24-48 h earlier. These mosquitoes were tested approximate to 2 wk later to determine infection, dissemination, and transmission rates. All five species [Culex quinquefasciatus Say, Culex univittatus Theobald, Culex vansomereni Edwards, Mansonia africana (Theobald), and Mansonia uniformis (Theobald)] were susceptible to infection, but disseminated infections were detected only in the three Culex, and not the two Mansonia species. Culex mosquitoes with a disseminated infection readily transmitted virus by bite, but even when inoculated with WNV, the two Mansonia failed to transmit virus, indicating a salivary gland barrier. These studies indicate that the three Culex species may play a role in the transmission of WNV in Kenya. C1 [Turell, Michael J.] USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Lutomiah, Joel L.; Muthoni, Milka; Limbaso, Samson; Sang, Rosemary C.] Kenya Govt Med Res Ctr, Nairobi, Kenya. [Koka, Hellen; Mutisya, James; Makio, Albina; Musila, Lillian; Schnabel, David] USA, Med Res Unit Kenya, Nairobi, Kenya. [Yalwala, Santos; Clark, Jeffrey W.; Kioko, Elizabeth] USA, Med Res Unit Kenya, Kisumu, Kenya. RP Turell, MJ (reprint author), USA, Div Virol, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@amedd.army.mi RI Valle, Ruben/A-7512-2013 FU USAMRU-K, Global Emerging Infections Surveillance and Response (GEIS) FX We thank Dunstone Beti and Reuben Lugalia (KEMRI) for assisting in the collection of the mosquitoes from the field and for identifying the mosquitoes; Johnston Ingonga and Francis Mulwa (KEMRI) for their assistance in rearing the mosquitoes; the ICIPE for providing the Cx. quinquefasciatus mosquitoes from their colony for use in this study, and Caroline Ochieng (Walter Reed Project-GEIS program) for sequencing the strain of WNV used in this study. We also thank Kathy Kenyon (USAMRIID) for editorial suggestions. This study was made possible through the financial support provided for by USAMRU-K, Global Emerging Infections Surveillance and Response (GEIS), whom we also thank. NR 25 TC 14 Z9 14 U1 0 U2 5 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2011 VL 48 IS 6 BP 1197 EP 1201 DI 10.1603/ME11062 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 849QK UT WOS:000297140000013 PM 22238879 ER PT J AU Kim, HC Klein, TA Takhampunya, R Evans, BP Mingmongkolchai, S Kengluecha, A Grieco, J Masuoka, P Kim, MS Chong, ST Lee, JK Lee, WJ AF Kim, Heung Chul Klein, Terry A. Takhampunya, Ratree Evans, Brian P. Mingmongkolchai, Sirima Kengluecha, Ampornpan Grieco, John Masuoka, Penny Kim, Myung-Soon Chong, Sung-Tae Lee, Jong-Koo Lee, Won-Ja TI Japanese Encephalitis Virus in Culicine Mosquitoes (Diptera: Culicidae) Collected at Daeseongdong, a Village in the Demilitarized Zone of the Republic of Korea SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Arbovirus; Culex tritaertiorhynchus; Culex bitaeniorhynchus; Korea ID INFECTION; SURVEILLANCE; AMERICANS; THAILAND; ANTIBODY AB In total, 22,846 (17,793 culicines and 5,053 Anopheles spp.) female mosquitoes were captured by a Mosquito Magnet trap at Daeseongdong, a small village adjacent to the military demarcation line (center of the demilitarized zone) in northern Gyeonggi Province, Republic of Korea (ROK). Culicine mosquitoes were identified to species, placed in pools of up to 30 mosquitoes each, and screened for flavivirus using a SYBR Green I-based real-time polymerase chain reaction. In total, 51/660 pools positive for flaviviruses and confirmed by DNA sequencing of the NS5 region, were positive for Japanese encephalitis virus (family Flaviviridae, genus Flavivirus, JEV) (50 Culex tritaeniorhynchus Giles and one Culex bitaeniorhynchus Giles). The JEV maximum likelihood estimations (MLEs) (estimated number of viral RNA-positive mosquitoes per 1,000) for Cx. tritaeniorhynchus and Cx. bitaeniorhynchus were 9.7 and 0.9, respectively. This is the first report of a Cx. bitaeniorhynchus positive for JEV in the ROK. JEV is a local civilian and military health threat and a significant concern for nonimmune (unvaccinated) U.S. soldiers, civilians, and family members deployed to the ROK. C1 [Lee, Jong-Koo; Lee, Won-Ja] Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Cheongwon Gun 363951, Chungbuk Provin, South Korea. [Kim, Heung Chul; Kim, Myung-Soon; Chong, Sung-Tae] 65th Med Brigade, Med Detachment 5, Multifunct Med Battal 168, Unit 15247, Seoul, South Korea. [Klein, Terry A.] 65th Med Brigade USAMEDDAC Korea, Force Hlth Protect & Prevent Med, Seoul, South Korea. [Takhampunya, Ratree; Evans, Brian P.; Mingmongkolchai, Sirima; Kengluecha, Ampornpan] Armed Forces Res Inst Med Sci, Dept Entomol, Mol Biol Sect, Bangkok 10400, Thailand. [Grieco, John; Masuoka, Penny] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Lee, WJ (reprint author), Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Cheongwon Gun 363951, Chungbuk Provin, South Korea. EM wonja@nih.go.kr RI LEE, Jong-koo/E-4166-2012; Valle, Ruben/A-7512-2013 FU Force Health Protection and Preventive Medicine, 65th Medical Brigade; Uniformed Services University, Bethesda, MD; AFHSC-GEIS, Silver Spring, MD; National Center for Medical Intelligence; Korea Centers for Disease Control and Prevention, Osong, Chungbuk Province, ROK; Korea National Institute of Health, Osong, Chungbuk Province, ROK; Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; 65th Medical Brigade, ROK FX We thank COL Hee-Choon S. Lee, Chief of Force Health Protection and Preventive Medicine, 65th Medical Brigade, for his support. Special thanks to Dong-Chan Kim (Daeseongdong village mayor), the ROK Army Commander, and ROK Army soldiers at JSA (provide security for Daeseongdong), for their assistance in mosquito collections. We also thank CAPT Clair Witt and Joel Gaydos, Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response System (AFHSC-GEIS), Silver Spring, MD, for administrative and technical support. This work was supported through the joint partnership between the Uniformed Services University, Bethesda, MD; the AFHSC-GEIS, Silver Spring, MD; the National Center for Medical Intelligence, the Korea Centers for Disease Control and Prevention, Osong, Chungbuk Province, ROK; the Korea National Institute of Health, Osong, Chungbuk Province, ROK; the Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand, and the 65th Medical Brigade, ROK. NR 44 TC 8 Z9 8 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2011 VL 48 IS 6 BP 1250 EP 1256 DI 10.1603/ME11091 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 849QK UT WOS:000297140000021 PM 22238887 ER PT J AU Staley, CS Morris, CJ Thiruvengadathan, R Apperson, SJ Gangopadhyay, K Gangopadhyay, S AF Staley, C. S. Morris, C. J. Thiruvengadathan, R. Apperson, S. J. Gangopadhyay, K. Gangopadhyay, S. TI Silicon-based bridge wire micro-chip initiators for bismuth oxide-aluminum nanothermite SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article ID POROUS SILICON; MICROTHRUSTER; CONDUCTIVITY; COMPOSITES AB We present a micro-manufacturing process for fabricating silicon-based bridge wire micro-chip initiators with the capacity to liberate joules of chemical energy at the expense of micro joules of input electrical energy. The micro-chip initiators are assembled with an open material reservoir utilizing a novel 47 degrees C melting point solder alloy bonding procedure and integrated with a bismuth oxide-aluminum nanothermite energetic composite. The electro-thermal conversion efficiency of the initiators is enhanced by the use of a nanoporous silicon bed which impedes thermal coupling between the bridge wire and bulk silicon substrate while maintaining the structural integrity of the device. Electrical behaviors of the ignition elements are investigated to extract minimum input power and energy requirements of 382.4 mW and 26.51 mu J, respectively, both in the absence and presence of an injected bismuth oxide-aluminum nanothermite composition. Programmed combustion of bismuth oxide-aluminum nanothermite housed within these initiators is demonstrated with a success rate of 100% over a 30 to 80 mu J range of firing energies and ignition response times of less than 2 mu s are achieved in the high input power operation regime. The micro-initiators reported here are intended for use in miniaturized actuation technologies. C1 [Staley, C. S.; Thiruvengadathan, R.; Apperson, S. J.; Gangopadhyay, K.; Gangopadhyay, S.] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. [Staley, C. S.; Apperson, S. J.; Gangopadhyay, K.] NEMS MEMS Works LLC, Columbia, MO 65202 USA. [Morris, C. J.] USA, Sensors & Electron Devices Directorate, Res Lab, AMSRD ARL SE RL, Adelphi, MD 20783 USA. RP Staley, CS (reprint author), Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA. EM cssdh8@mail.missouri.edu; christopher.j.morris58.civ@mail.mil; gangopadhyays@missouri.edu OI Thiruvengadathan, Rajagopalan/0000-0001-9609-3245 FU Leonard Wood Institute [LWI 400-044] FX This research is supported by the Leonard Wood Institute under LWI sub award number LWI 400-044. The authors appreciatively credit the US Army Research Laboratory for providing the resources necessary for device fabrication and thank Mr Brian Isaacson for technical assistance during wafer processing. NR 27 TC 20 Z9 21 U1 1 U2 14 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD NOV PY 2011 VL 21 IS 11 AR 115015 DI 10.1088/0960-1317/21/11/115015 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 844TX UT WOS:000296771900015 ER PT J AU Bradley, ML AF Bradley, Mark L. TI The Great Task Remaining Before Us: Reconstruction as America's Continuing Civil War. SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review C1 [Bradley, Mark L.] USA, Ctr Mil Hist, Washington, DC USA. RP Bradley, ML (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSOC PI ATHENS PA UNIV GEORGIA, HISTORY DEPT, ATHENS, GA 30602 USA SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD NOV PY 2011 VL 77 IS 4 BP 993 EP 995 PG 3 WC History SC History GA 848UV UT WOS:000297081500087 ER PT J AU Darlington, DN Delgado, AV Kheirabadi, BS Fedyk, CG Scherer, MR Pusateri, AE Wade, CE Cap, AP Holcomb, JB Dubick, MA AF Darlington, Daniel N. Delgado, Angel V. Kheirabadi, Bijan S. Fedyk, Chriselda G. Scherer, Michael R. Pusateri, Anthony E. Wade, Charles E. Cap, Andrew P. Holcomb, John B. Dubick, Michael A. TI Effect of Hemodilution on Coagulation and Recombinant Factor VIIa Efficacy in Human Blood In Vitro SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Meeting on Advanced Technology Applications for Combat Casualty Care (ATACCC) CY AUG 16-19, 2010 CL St Pete Beach, FL DE Hemorrhage; Coagulopathy; Hemodilution; Hemostasis; PT; aPTT; TEG ID ACTIVATED FACTOR-VII; NATURAL COLLOID RESUSCITATION; REQUIRING MASSIVE TRANSFUSION; COMBAT-RELATED CASUALTIES; DILUTIONAL COAGULOPATHY; HYDROXYETHYL STARCH; TRAUMA PATIENTS; TISSUE FACTOR; INCREASING HEMORRHAGE; FLUID RESUSCITATION AB Background: This study evaluates the effect of hemodilution by various common resuscitation fluids, and the efficacy of activated recombinant factor VII (rFVIIa) on coagulation parameters in human blood in vitro. Methods: Samples from normal healthy volunteers (n = 9) were hemodiluted from 0% to 90% with normal saline, or 0%, 40%, 60%, and 80% with 5% albumin, Hespan, Hextend, normal saline, or lactated Ringer's, and incubated at 37 degrees C +/- 1 degrees C for 30 minutes with and without rFVIIa (1.26 mu g/mL). Results: There was a strong correlation between the dilution of hemoglobin (Hb), platelets, or fibrinogen and coagulation parameters. Hemodilution 0% to 90% changed coagulation parameters (prothrombin time [PT], activated partial thromboplastin time [aPTT], and thromboelastography) in an exponential fashion; the greatest changes occurred after hemodilution lowered Hb <6 mg/dL, platelet count < 100,100/mm(3), and fibrinogen concentration <200 mg/dL. PT and aPTT were significantly prolonged after 60% and 80% dilution for all fluids. Hemodilution of 60% and 80% significantly decreased clot strength (maximum amplitude) and the kinetics of clot development (alpha angle) and increased the clot formation time (K). Hemodilution with Hextend and Hespan decreased maximum amplitude and alpha angle >5% albumin, lactated Ringer's, or normal saline. rFVIIa significantly improved PT at 60% and 80% dilutions, and aPTT at 80% dilution. There was a significant effect of dilution, but not fluid type, on the efficacy of rFVIIa to change PT and aPTT, and the onset of clotting (R). Conclusions: We have strong in vitro evidence that Hb >6 mg/dL, platelet count <100,000/mm(3), and fibrinogen concentration <200 mg/dL can be used as indexes of hemodilution-induced coagulopathy. This study also shows that Hextend and Hespan tend to decrease the clotting ability >5% albumin or the crystalloids. rFVIIa significantly decreased PT at all dilutions and aPTT at the highest dilution. The effectiveness of rFVIIa on PT and aPTT was significantly affected by the degree of dilution, but not by the type of fluid. C1 USA, Damage Control Resuscitat Program, Inst Surg Res, San Antonio, TX USA. USA, Blood Program, Inst Surg Res, San Antonio, TX USA. RP Darlington, DN (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM daniel.darlington@amedd.army.mil NR 64 TC 20 Z9 20 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2011 VL 71 IS 5 BP 1152 EP 1163 DI 10.1097/TA.0b013e318215178c PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 849IG UT WOS:000297118600018 PM 21610535 ER PT J AU Darlington, DN Kheirabadi, BS Delgado, AV Scherer, MR Martini, WZ Dubick, MA AF Darlington, Daniel N. Kheirabadi, Bijan S. Delgado, Angel V. Scherer, Michael R. Martini, Wenjun Z. Dubick, Michael A. TI Coagulation Changes to Systemic Acidosis and Bicarbonate Correction in Swine SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Meeting on Advanced Technology Applications for Combat Casualty Care (ATACCC) CY AUG 16-19, 2010 CL St Pete Beach, FL DE Coagulophathy; Thromboelastography; Thrombin generation; Activated clotting time; Rotational thromboelastogram ID BLOOD-VOLUME; INDEPENDENT CONTRIBUTIONS; MASSIVE TRANSFUSION; VASCULAR-RESISTANCE; COAGULOPATHY; HEMORRHAGE; TRAUMA; HYPOTHERMIA; DEATH; PIGS AB Background: As part of our overall interest in the mechanisms and treatment related to the development of the lethal triad of hypothermia, acidosis, and coagulopathy seen in trauma patients, the purpose of this study was to determine whether acidosis, inducible either by HCl infusion or hemorrhage/hypoventilation, leads to coagulopathy, and if correction of the acidosis will alleviate this coagulopathy. Methods: In two separate experiments, acidosis was induced in anesthetized swine by (1) HCl infusion (n = 10) or (2) hemorrhage/hypoventilation (n = 8). Arterial blood samples were taken before HCl infusion or hemorrhage (arterial pH 7.4), after HCl infusion or hemorrhage (pH 7.1), and after bicarbonate infusion to return pH to 7.4. Arterial pH and blood gases were measured every 15 minutes. Results: Acidosis (arterial pH 7.1) led to a hypocoagulation as measured by several coagulation parameters. In both experiments, acidosis was associated with a significant decrease in the maximum strength of the clot and the rate at which the clot formed. There was a significant decrease in endogenous thrombin potential and maximum thrombin concentration after acidosis in both groups (thrombin generation assay). However, the activated clotting time, prothrombin time, and activated partial thromboplastin time were significantly elevated only in the HCl-infused group. Fibrinogen concentration and platelet count were significantly reduced in both groups after acidosis. The hypocoagulation that was induced by either hemorrhage/hypoventilation or HCl infusion was not immediately corrected after returning pH to 7.4 with bicarbonate injection. Conclusions: These data suggest that acidosis induced by HCl infusion or by hemorrhage/hypoventilation leads to hypocoagulation. Simple correction of the arterial pH with bicarbonate is not sufficient to correct this coagulopathy. C1 [Darlington, Daniel N.; Kheirabadi, Bijan S.; Delgado, Angel V.; Scherer, Michael R.; Martini, Wenjun Z.; Dubick, Michael A.] USA, Inst Surg Res, Damage Control Resuscitat Program, Ft Sam Houston, TX 78234 USA. RP Darlington, DN (reprint author), USA, Inst Surg Res, Damage Control Resuscitat Program, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM darlington@amedd.army.mil NR 28 TC 15 Z9 17 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2011 VL 71 IS 5 BP 1271 EP 1277 DI 10.1097/TA.0b013e318214f522 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 849IG UT WOS:000297118600036 PM 21502874 ER PT J AU White, JM Cannon, JW Stannard, A Burkhardt, GE Spencer, JR Williams, K Oh, JS Rasmussen, TE AF White, Joseph M. Cannon, Jeremy W. Stannard, Adam Burkhardt, Gabriel E. Spencer, Jerry R. Williams, Ken Oh, John S. Rasmussen, Todd E. TI Direct Vascular Control Results in Less Physiologic Derangement Than Proximal Aortic Clamping in a Porcine Model of Noncompressible Extrathoracic Torso Hemorrhage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 24th Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 25-29, 2011 CL Naples, FL SP Eastern Assoc Surg Trauma DE Emergency thoracotomy; Resuscitative thoracotomy; Aortic cross-clamp; Hemorrhagic shock; Noncompressible hemorrhage; Vascular injury; Exsanguination; "Scoop and run" ID EMERGENCY-DEPARTMENT THORACOTOMY; LIFE-THREATENING COAGULOPATHY; FRESH-FROZEN PLASMA; RED-BLOOD-CELLS; ABDOMINAL EXSANGUINATION; LACTATE CLEARANCE; STILL USEFUL; OCCLUSION; RESUSCITATION; SHOCK AB Background: The optimal method of vascular control and resuscitation in patients with life-threatening, extrathoracic torso hemorrhage remains debated. Guidelines recommend emergency department thoracotomy (EDT) with aortic clamping, although transabdominal aortic clamping followed by vascular control and direct vascular control (DVC) without aortic clamping are alternatives. The objective of this study is to compare the effectiveness of three approaches to extrathoracic torso hemorrhage in a large animal model. Methods: Adolescent swine (Sus Scrofa) (mean weight = 80.9 kg) were randomized into three groups all of which had class IV shock established by hemorrhage from an iliac artery injury. Group 1: EDT with thoracic aortic clamping (N = 6); group 2: transabdominal supraceliac aortic clamping (SCC; N = 6); and group 3: DVC of bleeding site without aortic clamping (N = 6). After hemorrhage, EDT or SCC was performed in groups 1 and 2, respectively, with subsequent exploration of the bleeding site and placement of a temporary vascular shunt (TVS). Group 3 (DVC) underwent direct exploration of the injury and placement of a TVS. All groups were resuscitated to predefined physiologic endpoints over 6 hours with repeated measures of central and cerebral perfusion and end-organ function at standardized time points. Postmortem tissue analysis was performed to quantify injury to critical tissue beds. Results: There was no difference in mortality among the groups and no TVS failures. Central aortic pressure, carotid flow, and partial pressure brain tissue oximetry, all demonstrated increases in EDT and SCC after application of the aortic clamp relative to DVC (p < 0.05). During resuscitation, serum lactate levels were higher in EDT compared with SCC and DVC (6.85 vs. 3.08 and 2.15, respectively; p < 0.05) and serum pH in EDT reflected greater acidosis than SCC and DVC (7.24 vs. 7.36 and 7.39, respectively; p < 0.05). EDT and SCC required more intravenous fluid than DVC (2,166 mL and 2,166 mL vs. 667 mL, respectively; p < 0.05) and more vasopressors were used in EDT and SCC compared with DVC (52.1 mu g and 43.5 mu g vs. 12.4 mu g, respectively; p < 0.05). Brain and myocardial tissue stains demonstrated the same degree of acute ischemic changes in all groups. Conclusion: Although aortic clamping increases central and cerebral perfusion, DVC results in less physiologic derangement. The optimal method of aortic control would incorporate the benefits of maintained central pressure with less associated morbidity. Clinical studies evaluating DVC are warranted. C1 [White, Joseph M.; Stannard, Adam; Burkhardt, Gabriel E.; Spencer, Jerry R.; Rasmussen, Todd E.] USA, Inst Surg Res, Houston, TX 78236 USA. [Cannon, Jeremy W.] Brooke Army Med Ctr, Dept Surg, Houston, TX USA. [White, Joseph M.; Stannard, Adam; Burkhardt, Gabriel E.; Spencer, Jerry R.; Williams, Ken; Rasmussen, Todd E.] Clin Res Squadron, Lackland AFB, TX USA. [Stannard, Adam] Royal Ctr Def Med, Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. [Oh, John S.] Landstuhl Reg Med Ctr, Dept Surg, Landstuhl, Germany. [Cannon, Jeremy W.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers,Suite B, Houston, TX 78236 USA. EM todd.rasmussen@amedd.army.mil NR 28 TC 6 Z9 6 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2011 VL 71 IS 5 BP 1278 EP 1286 DI 10.1097/TA.0b013e318225052f PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 849IG UT WOS:000297118600037 PM 22071929 ER PT J AU Feathers, T Stinner, D Kirk, K Kirby, J Hsu, JR AF Feathers, Todd Stinner, Daniel Kirk, Kevin Kirby, Jess Hsu, Joseph R. CA Brooke Army Med Ctr TI Effectiveness of the Saline Load Test in Diagnosis of Traumatic Elbow Arthrotomies SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT Annual Meeting of the Society-of-Military-Orthopaedic-Surgeons CY DEC 19, 2009 CL Honolulu, HI SP Soc Mil Orthopaed Surg DE Saline load test; Periarticular elbow lacerations; Traumatic Arthrotomies ID OPEN JOINT INJURIES; KNEE; MANAGEMENT AB Objectives: The purpose of this study was to investigate the amount of fluid required and the sensitivity of the saline load test to identify an intra-articular arthrotomy of the elbow. Methods: A cadaveric study was conducted using 36 thawed, fresh-frozen forequarter amputations. An elbow arthrotomy was made in the posterocentral arthroscopic portal site with a 4.5-mm trochar. To confirm intra-articular location of the arthrotomy, the trochar was trapped in the ulnohumeral joint. The elbow joint was then loaded with saline mixed with methylene blue. During the injection, the known arthrotomy site was observed for leakage. If no leakage occurred after loading 20 mL of fluid, the elbow was taken through a range of motion. If still no leakage was appreciated at the arthrotomy site, the elbow was again infused with fluid in 2 mL increments until outflow. All injections were confirmed as intra-articular by demonstrating methylene blue staining of the anterior joint by open exploration. Results: A positive result was obtained in 26 of the 36 elbows (72% sensitivity) with injection of 20 mL of fluid, and with the addition of range of motion, another 5 elbows demonstrated leakage, raising the sensitivity to 86%. However, to identify 95% of arthrotomies, a total of 40 mL of fluid had to be injected. Conclusions: Our results demonstrate that 40 mL of fluid must be injected to identify the majority of traumatic arthrotomies about the elbow. Moreover, adding range of motion after the injection increases the detection rate. C1 [Feathers, Todd; Stinner, Daniel; Kirk, Kevin; Hsu, Joseph R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Kirby, Jess] Ryder Trauma Ctr, Miami, FL USA. RP Feathers, T (reprint author), 6967 Caribou Creek, San Antonio, TX 78244 USA. EM toddfeathers@aol.com OI Stinner, Daniel/0000-0002-8981-6262 NR 15 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2011 VL 71 IS 5 BP E110 EP E113 DI 10.1097/TA.0b013e3182127840 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 849IG UT WOS:000297118600002 PM 21768902 ER PT J AU Cannon, DW McCollum, J AF Cannon, David W. McCollum, Jeffery TI Army Medical Department Lessons Learned Program Marks 25th Anniversary SO MILITARY MEDICINE LA English DT Article AB The year 2010 marked the 25th anniversary of the Center for Army Lessons Learned (CALL) as well as the Army Medical Department (AMEDD) Center and School's Lessons Learned Division. In the aftermath of Operation Urgent Fury in 1983, the Army recognized the need to create an organization whose sole purpose was to collect, review, and analyze lessons learned and created the CALL in 1985 at Fort Leavenworth, Kansas. The AMEDD followed suit and established the Medical Information System/AMEDD Lessons Learned office under the Directorate of Evaluation and Standardization to research and compile lessons learned as the AMEDD's point of contact for the CALL program. Over these past 25 years the AMEDD Center and School Lessons Learned program evolved and underwent organizational realignments, but the overall mission continues to promote changes either directly or indirectly in the AMEDD's Doctrine, Organizations, Training, Leader Development, Materiel, Personnel and Facilities domains and capabilities to provide combat health service support on the battlefield. C1 [Cannon, David W.; McCollum, Jeffery] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Cannon, DW (reprint author), USA, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1212 EP 1214 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300003 PM 22165647 ER PT J AU Marshall, RC Doperak, M Milner, MM Motsinger, C Newton, T Padden, M Pastoor, S Hughes, CL LeFurgy, J Mun, SK AF Marshall, Robert C. Doperak, Martin Milner, Maj Michelle Motsinger, Charles Newton, Terry Padden, Maureen Pastoor, Sara Hughes, Cortney L. LeFurgy, Jennifer Mun, Seong K. TI Patient-Centered Medical Home: An Emerging Primary Care Model and the Military Health System SO MILITARY MEDICINE LA English DT Article ID TEAMLET MODEL; TRANSFORMATION AB The Patient-Centered Medical Home (PCMH) is a primary care model that aims to provide quality care that is coordinated, comprehensive, and cost-effective. PCMH is hinged upon building a strong patient provider relationship and using a team-based approach to care to increase continuity and access. It is anticipated that PCMH can curb the growth of health care costs through better preventative medicine and lower utilization of services. The Navy, Air Force, and Army are implementing versions of PCMH, which includes the use of technologies for improved documentation, better disease management, improved communication between the care teams and patients, and increased access to care. This article examines PCMH in the Military Health System by providing examples of the transition from each of the branches. The authors argue that the military must overcome unique challenges to implement and sustain PCMH that civilian providers may not face because of the deployment of patients and staff, the military's mission of readiness, and the use of both on-base and off-base care by beneficiaries. Our objective is to lay out these considerations and to provide ways that they have been or can be addressed within the transition from traditional primary care to PCMH. C1 [Marshall, Robert C.; Padden, Maureen] USN, Bur Med & Surg, Washington, DC 20372 USA. [Doperak, Martin] HQDA, Off Surg Gen Army, Dept Def, Falls Church, VA 22041 USA. [Milner, Maj Michelle] Malcolm Grow Hosp, Andrews AFB, MD 20762 USA. [Motsinger, Charles; Newton, Terry] MACH, Dept Family Med, Benning, GA 31905 USA. [Pastoor, Sara] Brooke Army Med Ctr, San Antonio, TX 78234 USA. [Hughes, Cortney L.; LeFurgy, Jennifer; Mun, Seong K.] Virginia Tech, Arlington Innovat Ctr Hlth Res, Arlington, VA 22203 USA. RP Marshall, RC (reprint author), USN, Bur Med & Surg, 2300 E St NW, Washington, DC 20372 USA. FU HighView Cooperative Research and Development Agreement [W81XWH-08-2-0173]; Telemedicine and Advanced Technology Research Center; U.S. Army Medical Research and Materiel Command FX The authors would particularly like to thank Jennifer LeFurgy and Kenneth Wong for their organization of the Medical Home workshop on June 30, 2010 at the George Washington Masonic Temple in Alexandria, VA. This work is in part supported by HighView Cooperative Research and Development Agreement, W81XWH-08-2-0173, Telemedicine and Advanced Technology Research Center, and U.S. Army Medical Research and Materiel Command. NR 24 TC 4 Z9 4 U1 0 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1253 EP 1259 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300008 PM 22165652 ER PT J AU Grier, TL Morrison, S Knapik, JJ Canham-Chervak, M Jones, BH AF Grier, Tyson L. Morrison, Stephanie Knapik, Joseph J. Canham-Chervak, Michelle Jones, Bruce H. TI Risk Factors for Injuries in the U.S. Army Ordnance School SO MILITARY MEDICINE LA English DT Article ID SMOKELESS TOBACCO USE; EXERCISE-RELATED INJURIES; PHYSICAL-FITNESS; US-ARMY; CIGARETTE-SMOKING; YOUNG MEN; WOMEN; HISTORY; SMOKERS; SOCCER AB Objective: To investigate risk factors for time-loss injuries among soldiers attending U.S. Army Ordnance School Advanced Individual Training. Methods: Injuries were obtained from an injury surveillance system. A health questionnaire provided data on age, race, rank, current self-reported injury and illness, and tobacco use. Fitness data was obtained from operations office. Results: Cumulative time-loss injury incidence was 31% for men and 54% for women. For men, higher risk of injury was associated with race, a current self-reported injury, smoking before entering the Army, lower sit-up performance, and slower 2-mile run times. For women, higher risk of injury was associated with race, a current self-reported injury, and slower 2-mile run times. Conclusion: Smoking cessation and fitness training before entry are potential strategies to reduce injuries among soldiers in the Ordnance School. C1 [Grier, Tyson L.; Morrison, Stephanie; Knapik, Joseph J.; Canham-Chervak, Michelle; Jones, Bruce H.] USA, Publ Hlth Command, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Grier, TL (reprint author), USA, Publ Hlth Command, Directorate Epidemiol & Dis Surveillance, 5158 Blackhawk Rd,Bldg 1570, Aberdeen Proving Ground, MD 21010 USA. NR 40 TC 9 Z9 9 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1292 EP 1299 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300015 PM 22165659 ER PT J AU Folio, L Fischer, T Shogan, PJ Frew, M Bunger, R Provenzale, JM AF Folio, Les Fischer, Tatjana Shogan, Paul J. Frew, Michael Bunger, Rolf Provenzale, James M. TI Cartesian Positioning System for Localization of Blast and Ballistic Fragments: A Phantom-Based Pilot Study SO MILITARY MEDICINE LA English DT Article ID BULLET AB Our purpose was to demonstrate the consistency of radiologists' three-dimensional measurements of simulated blast fragment locations in vitro in an effort to objectively localize retained fragments and wound paths. We designed a phantom consisting of 10 nail heads (simulating blast fragments) glued to wooden pegs that were randomly situated at distances from a reference point within a plastic tub. The x, y, and z coordinates of simulated fragments were recorded in Cartesian 3-space relative to the reference point. Computed tomography images of the phantom were acquired. Differences in x, y, and z positions as determined by three observers were summed for each fragment. Agreement between recordings of coordinates across readers was assessed using the intraclass correlation coefficient. Summed differences in coordinate positions as determined by readers ranged between 0.00 and 1.204 cm (mean: 0.732 cm). Across readers, the intraclass correlation coefficient for each dimension was >0.99. We found excellent agreement among readers with minimal discrepancy of measured locations of simulated fragments. Our results provide a foundation for trajectory analysis necessary to lead to automated organ damage reporting for immediate assessment in the emergency department and for forensic investigation and long-term epidemiological analysis. C1 [Folio, Les] NIH, Bethesda, MD 20892 USA. [Fischer, Tatjana] Tech Univ Munich, D-80333 Munich, Germany. [Shogan, Paul J.] Walter Reed Army Med Ctr, Natl Capital Consortium, Dept Radiol, Washington, DC 20307 USA. [Shogan, Paul J.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA. [Provenzale, James M.] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27705 USA. [Provenzale, James M.] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA. [Provenzale, James M.] Emory Univ, Sch Med, Dept Biomed Engn, Atlanta, GA 30322 USA. [Provenzale, James M.] Emory Univ, Sch Med, Dept Oncol, Atlanta, GA 30322 USA. RP Folio, L (reprint author), NIH, 10 Ctr Dr, Bethesda, MD 20892 USA. NR 13 TC 3 Z9 3 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1300 EP 1305 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300016 PM 22165660 ER PT J AU Bui-Mansfield, LT Cressler, DK AF Bui-Mansfield, Liem T. Cressler, Dana K. TI Imaging of Hemorrhagic Fever With Renal Syndrome: A Potential Bioterrorism Agent of Military Significance SO MILITARY MEDICINE LA English DT Article ID HANTAVIRUS-PULMONARY-SYNDROME; TO-PERSON TRANSMISSION; ACUTE-PANCREATITIS; ARGENTINA; KIDNEY; CT; MANIFESTATIONS; INVOLVEMENT; INFECTION; OUTBREAK AB Hemorrhagic fever with renal syndrome (HFRS) is a potentially fatal infectious disease with worldwide distribution. Its etiologic agents are viruses of the genus Hantavirus of the virus family Bunyaviridae. Hypothetical ease of production and distribution of these agents, with their propensity to incapacitate victims and overwhelm health care resources, lend themselves as significant potential biological agents of terrorism. HFRS has protean clinical manifestations, which may mimic upper respiratory tract infection, nephrolithiasis, and Hantavirus pulmonary syndrome and may delay proper treatment. Sequelae of HFRS, such as hemorrhage, acute renal failure, retroperitoneal edema, pancreatitis, pulmonary edema, and neurologic symptoms, can be detected by different imaging modalities. Medical providers caring for HFRS patients must be aware of its radiologic features, which may help to confirm its clinical diagnosis. In this article, the authors review the epidemiology, pathophysiology, clinical presentation, diagnosis, treatment, and complications of HFRS. C1 [Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. [Bui-Mansfield, Liem T.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Nucl Med, Bethesda, MD 20814 USA. [Cressler, Dana K.] Wilford Hall USAF Med Ctr, Dept Radiol, Lackland AFB, TX 78236 USA. RP Bui-Mansfield, LT (reprint author), Brooke Army Med Ctr, Dept Radiol, 3851 Rodger Brook Dr, Ft Sam Houston, TX 78234 USA. NR 34 TC 2 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1327 EP 1334 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300021 PM 22165665 ER PT J AU Rittenhouse, B Hill-Pryor, CD McConathy, A Parker, P Franco, N Toussaint, E Barker, D Prasad, B Pizarro, JM AF Rittenhouse, Bradley Hill-Pryor, Crystal D. McConathy, Adam Parker, Peter Franco, Nelson Toussaint, Esra Barker, Darrell Prasad, Balakrishna Pizarro, Jose M. TI Effect of Combined Nicotine and Shrapnel Exposure on Pain Measures and Gait After Nerve Injury SO MILITARY MEDICINE LA English DT Article ID RAT; HYPERSENSITIVITY; MILITARY; BEHAVIOR; IMPACT AB A significant fraction of military soldiers sustain nerve injury and use tobacco or nicotine containing products. Healing of nerve injuries is influenced by many factors, such as degree of original injury, healing potential of the nerve, and general health of patient. However, recently, it has been demonstrated that the presence of retained insoluble metal fragments decreases healing. The effects of systemic nicotine administration, with or without metal fragments at the site of nerve injury, were evaluated. Both the nicotine-administered groups (nicotine, nicotine + shrapnel) showed significant increase in the peroneal function compared with untreated controls, as assessed by paw area (p < 0.05). Furthermore, to test possible role of altered sensory function, we used the hot plate assay. Latency to withdraw paw from a hot plate was significantly shorter in nicotine groups (p < 0.05). These data indicate that nicotine improves sensory and motor aspects of nerve function, in the presence or absence of shrapnel. C1 [Rittenhouse, Bradley; Barker, Darrell] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. [Hill-Pryor, Crystal D.; McConathy, Adam; Parker, Peter; Franco, Nelson; Toussaint, Esra; Prasad, Balakrishna; Pizarro, Jose M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA. RP Rittenhouse, B (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. FU Uniformed Services University of the Health Sciences [60042-300392-14.0] FX This project was supported by a grant from Uniformed Services University of the Health Sciences (Award No. 60042-300392-14.0). NR 19 TC 1 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2011 VL 176 IS 11 BP 1335 EP 1340 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 845NR UT WOS:000296830300022 PM 22165666 ER PT J AU Nguyen, H Ivanova, VS Kavandi, L Rodriguez, GC Maxwell, GL Syed, V AF Huyen Nguyen Ivanova, Vessela S. Kavandi, Leyla Rodriguez, Gustavo C. Maxwell, George L. Syed, Viqar TI Progesterone and 1,25-Dihydroxyvitamin D-3 Inhibit Endometrial Cancer Cell Growth by Upregulating Semaphorin 3B and Semaphorin 3F SO MOLECULAR CANCER RESEARCH LA English DT Article ID LUNG-CANCER; ORAL-CONTRACEPTIVES; TUMOR PROGRESSION; OVARIAN-CARCINOMA; EXPRESSION; APOPTOSIS; RECEPTOR; SEMA3F; MICE; RISK AB Class 3 semaphorins (SEMA), SEMA3B and SEMA3F, are secreted proteins that regulate angiogenesis, tumor growth, and metastasis by binding to their transmembrane receptor complex consisting of plexins and neuropilins (NP). Expression of SEMAs and their receptors was assessed in tissue microarrays by immunohistochemistry. SEMA3B, SEMA3F, and plexin A3 were expressed strongly in normal endometrial tissues, whereas grade-dependent decreases were found in endometrial carcinomas. No change was observed in the expression of plexin A1, NP1, and NP2 in normal versus endometrial cancer tissues. Endometrial cancer cells showed decreased expression of SEMA3B, SEMA3F, and plexin A3 compared with their normal counterparts. Treatment of cancer cells with progesterone (P4) and 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3] for a period of 72 hours induced a significant upregulation of SEMA3B and SEMA3F as well as inhibited growth of cancer cells by increasing caspase-3 activity. Cotreatment of cell lines with P4 or 1,25(OH)(2)D-3 and their respective antagonists confirmed the specificity of their actions. Transfection of siRNA-targeting SEMA3B and SEMA3F in endometrial cancer cells attenuated P4 or 1,25(OH)(2)D-3-induced growth inhibition. Restoration of SEMA3B or SEMA3F expression in cancer cells caused growth inhibition, reduced soft agar colony formation, and cell invasiveness by inhibiting expression of matrix metalloproteinase-2 (MMP-2), MMP-9, integrin alpha v beta 3, and proangiogenic genes and by upregulating antiangiogenic genes. Thus, we have identified two new P4 and 1,25(OH)(2)D-3-regulated antitumor genes for endometrial cancer. These results suggest that the loss of SEMAs contribute to the malignant phenotype of endometrial cancer cells and that reexpression of SEMAs by ectopic expression or with anticancer agents P4 or 1,25(OH)(2)D-3 can be a promising therapeutic treatment against endometrial cancer. Mol Cancer Res; 9(11); 1479-92. (C) 2011 AACR. C1 [Huyen Nguyen; Ivanova, Vessela S.; Kavandi, Leyla; Syed, Viqar] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. [Rodriguez, Gustavo C.] Univ Chicago, Div Gynecol Oncol, NorthShore Univ HealthSyst, Chicago, IL 60637 USA. [Maxwell, George L.] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. [Maxwell, George L.] Inova Hlth Syst, Womens Hlth Integrated Res Ctr, Annandale, VA USA. RP Syed, V (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Room A-3080,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM viqar.syed@usuhs.mil FU NIH [CA123558]; Uniformed Services University of the Health Science, Bethesda, Maryland FX This study was supported, in part, by NIH grant CA123558 (to V. Syed) and startup funds from the Uniformed Services University of the Health Science, Bethesda, Maryland. NR 51 TC 15 Z9 16 U1 0 U2 7 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1541-7786 J9 MOL CANCER RES JI Mol. Cancer Res. PD NOV PY 2011 VL 9 IS 11 BP 1479 EP 1492 DI 10.1158/1541-7786.MCR-11-0213 PG 14 WC Oncology; Cell Biology SC Oncology; Cell Biology GA 850QH UT WOS:000297211100006 PM 21933904 ER PT J AU Wilson, DJ Parada, SA Slevin, JM Arrington, ED AF Wilson, David J. Parada, Stephen A. Slevin, John M. Arrington, Edward D. TI Intrasubstance Ruptures of the Biceps Brachii: Diagnosis and Management SO ORTHOPEDICS LA English DT Review ID TRAUMATIC CLOSED TRANSECTION; ELECTROMYOGRAPHIC ANALYSIS; SHORT HEAD; MUSCLE; INJURIES; PARACHUTISTS; ELBOW AB Traumatic intrasubstance ruptures of the biceps brachii are rare and historically specific to military static line parachute jumps; however, these injuries have recently been reported in the civilian literature. Diagnosis is made by history, clinical weakness in supination and elbow flexion, extensive ecchymosis and edema, and a palpable defect. Ultrasound and magnetic resonance imaging are useful to confirm the diagnosis and injury severity. Nonoperative treatment involves splinting in acute flexion. Percutaneous hematoma aspiration has been described. Early surgical intervention with primary repair has been shown to be more successful than late reconstruction. Studies comparing operative and nonoperative treatment are lacking. C1 [Wilson, David J.; Parada, Stephen A.; Slevin, John M.; Arrington, Edward D.] USA, Dept Orthopaed Surg, Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Arrington, ED (reprint author), USA, Dept Orthopaed Surg, Madigan Army Med Ctr, 9040A Fitzsimmons Dr, Tacoma, WA 98431 USA. EM edward.arrington@us.army.mil NR 20 TC 3 Z9 3 U1 0 U2 2 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD NOV PY 2011 VL 34 IS 11 BP 890 EP 896 DI 10.3928/01477447-20110922-25 PG 7 WC Orthopedics SC Orthopedics GA 846YX UT WOS:000296940200015 PM 22050257 ER PT J AU Cozza, KL Wynn, GH AF Cozza, Kelly L. Wynn, Gary H. TI SRIs and Bleeding; Transporters; Metformin and Olanzapine SO PSYCHOSOMATICS LA English DT Editorial Material C1 [Cozza, Kelly L.; Wynn, Gary H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Cozza, Kelly L.] Walter Reed Natl Mil Med Ctr, Dept Psychiat, Bethesda, MD USA. [Wynn, Gary H.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA. RP Cozza, KL (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. NR 3 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD NOV-DEC PY 2011 VL 52 IS 6 BP 589 EP 592 PG 4 WC Psychiatry; Psychology SC Psychiatry; Psychology GA 849PJ UT WOS:000297137300017 ER PT J AU Burns, JW Baer, LA Jones, JA Dubick, MA Wade, CE AF Burns, John W. Baer, Lisa A. Jones, John A. Dubick, Michael A. Wade, Charles E. TI Severe controlled hemorrhage resuscitation with small volume poloxamer 188 in sedated miniature swine SO RESUSCITATION LA English DT Article DE 60% hemorrhage; Thromboelastogram (TEG); Survival; Surfactant; Metabolic acidosis; Hypotension; Coagulopathy ID PLURONIC F-68; PURIFIED POLOXAMER-188; 6-PERCENT DEXTRAN; FEMALE-PATIENTS; SHOCK; MODEL; INJURY; SURVIVAL; HYPERCOAGULABILITY; COAGULATION AB Background: The surfactant poloxamer 188 (P188) has been shown to improve survival following hemorrhage. This study used P188 as a small volume resuscitation product in a sedated, sexually mature, male miniature swine severe hemorrhage model for potential improvement in rate and time of survival. Methods: Fourteen swine were anesthetized, catheterized for hemorrhage and resuscitation and allowed to recover from anesthesia. The animals were sedated and hemorrhaged 60% of estimated blood volume (similar to 39 ml kg(-1)) exponentially over 1 h. Following hemorrhage the animals were treated with either 1.33 ml kg(-1) of P188 (150 mg ml(-1); 7 swine) or the P188 citrate vehicle (7 swine) given as an i.v. infusion over 2 min without additional resuscitation fluids. The data were compared with control data from sedated swine similarly hemorrhaged, but with no resuscitation (untreated; n = 16). Results: Median (95% CI) survival time for the untreated control swine was 55.8 (36.5-86) min with a 6% survival at 180 min. Median survival time of 161 (80-180) min for the P188 swine was significantly greater than control (p = 0.0186), whereas the citrate vehicle median survival time of 91 (32-180) min was not significantly different from control or P188. At the survival target time of 180 min, survival rates were not significantly different among the three groups. TEG data from swine demonstrated anti-coagulant properties of P188. This was confirmed with human blood ex vivo. Conclusion: In the presence of severe controlled hemorrhage, P188 improved median survival time. However, retardation of blood clotting raises concerns as to its use in the presence of uncontrolled hemorrhage. Published by Elsevier Ireland Ltd. C1 [Burns, John W.; Baer, Lisa A.; Jones, John A.; Dubick, Michael A.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Burns, John W.] PCMS, Atlanta, GA USA. RP Dubick, MA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM jburns@beecreek.net; lisa.baer@uth.tmc.edu; john.jones@amedd.army.mil; michael.dubick@amedd.army.mil; charles.e.wade@uth.tmc.edu NR 31 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD NOV PY 2011 VL 82 IS 11 BP 1453 EP 1459 DI 10.1016/j.resuscitation.2011.06.007 PG 7 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA 849DD UT WOS:000297104800021 PM 21733612 ER PT J AU De Martino, RR Brewster, LP Kokkosis, AA Glass, C Boros, M Kreishman, P Kauvar, DA Farber, A AF De Martino, Randall R. Brewster, L. P. Kokkosis, A. A. Glass, C. Boros, M. Kreishman, P. Kauvar, D. A. Farber, A. TI The Perspective of the Vascular Surgery Trainee on New ACGME Regulations, Fatigue, Resident Training, and Patient Safety SO VASCULAR AND ENDOVASCULAR SURGERY LA English DT Article DE duty hours; vascular training; ACGME ID INSTITUTE-OF-MEDICINE; HOURS ENHANCING SLEEP; DUTY HOUR REFORM; 80-HOUR WORKWEEK; SUPERVISION; MORTALITY; CARE; ASSOCIATION; DEPRIVATION; PERFORMANCE AB Objective: To assess the opinions of vascular surgery trainees on the new Accreditation Council for Graduate Medical Education (ACGME) guidelines. Methods: A questionnaire was developed and electronically distributed to trainee members of the Society for Vascular Surgery. Results: Of 238 eligible vascular trainees, 38 (16%) participated. Respondents were predominantly 30 to 35 years of age (47%), male (69%), in 2-year fellowship (73%), and at large academic centers (61%). Trainees report occasionally working while fatigued (63%). Fellows were more likely to report for duty while fatigued (P = .012) than integrated vascular residents. Respondents thought further work-hour restrictions would not improve patient care or training (P < .05) and may not lead to more sleep or improved quality of life. Respondents reported that duty hours should vary by specialty (81%) and allow flexibility in the last years of training (P < .05). Conclusions: Vascular surgery trainees are concerned about further duty-hour restrictions on patient care, education, and training and fatigue mitigation has to be balanced against the need to adequately train vascular surgeons. C1 [De Martino, Randall R.] Dartmouth Hitchcock Med Ctr, Vasc Surg Sect, Lebanon, NH 03766 USA. [Brewster, L. P.] Emory Clin, Dept Surg, Decatur, GA USA. [Kokkosis, A. A.] Mt Sinai Med Ctr, Dept Surg, New York, NY 10029 USA. [Glass, C.] Univ Rochester, Med Ctr, Dept Surg, Rochester, NY 14642 USA. [Boros, M.] Munson Med Ctr, Traverse City, MI USA. [Kreishman, P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Kauvar, D. A.] Univ Utah, Div Vasc Surg, Salt Lake City, UT USA. [Farber, A.] Boston Med Ctr, Sect Vasc & Endovasc Surg, Boston, MA USA. RP De Martino, RR (reprint author), Dartmouth Hitchcock Med Ctr, Vasc Surg Sect, 1 Med Ctr Dr,3V, Lebanon, NH 03766 USA. EM randall.r.de.martino@hitchcock.org OI Kokkosis, Angela A/0000-0002-2408-3010 NR 31 TC 4 Z9 4 U1 1 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 1538-5744 J9 VASC ENDOVASC SURG JI Vasc. Endovasc. Surg. PD NOV PY 2011 VL 45 IS 8 BP 697 EP 702 DI 10.1177/1538574411418130 PG 6 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 846TL UT WOS:000296926000003 PM 22262113 ER PT J AU Enewold, LR Zhou, J Devesa, SS de Gonzalez, AB Anderson, WF Zahm, SH Stojadinovic, A Peoples, GE Marrogi, AJ Potter, JF McGlynn, KA Zhu, KM AF Enewold, Lindsey R. Zhou, Jing Devesa, Susan S. de Gonzalez, Amy Berrington Anderson, William F. Zahm, Shelia H. Stojadinovic, Alexander Peoples, George E. Marrogi, Aizenhawar J. Potter, John F. McGlynn, Katherine A. Zhu, Kangmin TI Thyroid Cancer Incidence among Active Duty US Military Personnel, 1990-2004 SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID REPRODUCTIVE FACTORS; INCREASING INCIDENCE; UNITED-STATES; TIME TRENDS; CARCINOMA; POPULATION; EXPOSURE; RATES; PAPILLARY; DISEASE AB Background: Increases in thyroid papillary carcinoma incidence rates have largely been attributed to heightened medical surveillance and improved diagnostics. We examined papillary carcinoma incidence in an equal-access health care system by demographics that are related to incidence. Methods: Incidence rates during 1990-2004 among white and black individuals aged 20 to 49 years in the military, and the general U. S. population were compared using data from the Department of Defense's Automated Central Tumor Registry and the National Cancer Institute's Surveillance Epidemiology and End Results (SEER-9) program. Results: Incidence was significantly higher in the military than in the general population among white women [incidence rate ratio (IRR) = 1.42; 95% confidence interval (CI), 1.25-1.61], black women (IRR = 2.31; 95% CI, 1.70-2.99), and black men (IRR = 1.69, 95% CI, 1.10-2.50). Among whites, differences between the two populations were confined to rates of localized tumors (women: IRR = 1.73, 95% CI, 1.47-2.00; men: IRR = 1.51, 95% CI, 1.30-1.75), which may partially be due to variation in staging classification. Among white women, rates were significantly higher in the military regardless of tumor size and rates rose significantly over time both for tumors <= 2 cm (military: IRR = 1.64, 95% CI, 1.18-2.28; general population: IRR = 1.55, 95% CI, 1.45-1.66) and >2 cm (military: IRR = 1.74, 95% CI, 1.07-2.81; general population: IRR = 1.48, 95% CI, 1.27-1.72). Among white men, rates increased significantly only in the general population. Incidence also varied by military service branch. Conclusions: Heightened medical surveillance does not appear to fully explain the differences between the two populations or the temporal increases in either population. Impact: These findings suggest the importance of future research into thyroid cancer etiology. Cancer Epidemiol Biomarkers Prev; 20(11); 2369-76. (C) 2011 AACR. C1 [Enewold, Lindsey R.; Zhou, Jing; Stojadinovic, Alexander; Peoples, George E.; Marrogi, Aizenhawar J.; Potter, John F.; Zhu, Kangmin] Henry M Jackson Fdn, US Mil Canc Inst, Walter Reed Army Med Ctr, Rockville, MD 20852 USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Marrogi, Aizenhawar J.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Marrogi, Aizenhawar J.] Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. [Devesa, Susan S.; de Gonzalez, Amy Berrington; Anderson, William F.; Zahm, Shelia H.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Potter, John F.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Enewold, LR (reprint author), Henry M Jackson Fdn, US Mil Canc Inst, Walter Reed Army Med Ctr, 11300 Rockville Pike,Suite 1215, Rockville, MD 20852 USA. EM lenewold@hjfresearch.org RI Zahm, Shelia/B-5025-2015 FU United States Military Cancer Institute (USMCI) via Uniformed Services University of the Health Sciences under Henry M. Jackson Foundation for the Advancement of Military Medicine; Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute FX This research was supported by the United States Military Cancer Institute (USMCI) via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine and by the Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute. NR 48 TC 16 Z9 20 U1 0 U2 6 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD NOV PY 2011 VL 20 IS 11 BP 2369 EP 2376 DI 10.1158/1055-9965.EPI-11-0596 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 844RO UT WOS:000296765200005 PM 21914838 ER PT J AU Farrington, HL Petren, K AF Farrington, Heather L. Petren, Kenneth TI A CENTURY OF GENETIC CHANGE AND METAPOPULATION DYNAMICS IN THE GALAPAGOS WARBLER FINCHES (CERTHIDEA) SO EVOLUTION LA English DT Article DE Gene flow; genetic monitoring; museum specimens; natural history collections; population genetics; SSR ID EFFECTIVE POPULATION-SIZE; MAXIMUM-LIKELIHOOD-ESTIMATION; ALLELE FREQUENCY DATA; DARWINS FINCHES; MIGRATION RATES; ANCIENT DNA; HABITAT FRAGMENTATION; COALESCENT APPROACH; TROUT POPULATIONS; MUSEUM SPECIMENS AB Populations that are connected by immigrants play an important role in evolutionary and conservation biology, yet we have little direct evidence of how such metapopulations change genetically over evolutionary time. We compared historic (1894-1906) to modern (1988-2006) genetic variation in 11 populations of warbler finches at 14 microsatellite loci. Although several lines of evidence suggest that Darwin's finches may be in decline, we found that the genetic diversity of warbler finches has not generally declined, and broad-scale patterns of variation remained similar over time. Contrary to expectations, inferred population sizes have generally increased over time (6-8%) as have immigration rates (8-16%), which may reflect a recent increase in the frequency and intensity of El Nino events. Individual island populations showed significant declines (18-19%) and also substantial gains (18-20%) in allelic richness over time. Changes in genetic diversity were correlated with changes in immigration rates, but did not correspond to population size or human disturbance. These results reflect the expected stabilizing properties of whole metapopulations over time. However, the dramatic and unpredictable changes observed in individual populations during this short time interval suggests that care should be taken when monitoring individual population fragments with snapshots of genetic variation. C1 [Farrington, Heather L.; Petren, Kenneth] Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA. [Farrington, Heather L.] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Farrington, HL (reprint author), Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA. EM Heather.L.Farrington@usace.army.mil FU National Science Foundation [DEB-0317687]; Sigma Xi; American Ornithologists' Union; University of Cincinnati University Research Council FX We thank T. Chesser and J. Cracraft of the American Museum of Natural History, J. Dumbacher, M. Flannery, D. Long, and L. Baptista of the California Academy of Sciences and R. Prys-Jones from the British Natural History Museum for access to valuable historical specimens. We thank the Galapagos National Parks and Charles Darwin Research Station for field support. We thank K. Short, J. Niedzwiecki, and E. Ristagno for laboratory and field assistance and H. Lisle Gibbs, T. Culley, S. Matter, R. DeBry, L. Kubatko and two anonymous reviewers for constructive comments. This work was partially supported by the National Science Foundation (DEB-0317687 to KP), Sigma Xi, The American Ornithologists' Union and the University of Cincinnati University Research Council and Wieman-Wendell grant funds. NR 83 TC 5 Z9 5 U1 3 U2 35 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0014-3820 J9 EVOLUTION JI Evolution PD NOV PY 2011 VL 65 IS 11 BP 3148 EP 3161 DI 10.1111/j.1558-5646.2011.01385.x PG 14 WC Ecology; Evolutionary Biology; Genetics & Heredity SC Environmental Sciences & Ecology; Evolutionary Biology; Genetics & Heredity GA 843VK UT WOS:000296702800011 PM 22023582 ER PT J AU Shen-Gunther, J Yu, X AF Shen-Gunther, Jane Yu, Xin TI HPV molecular assays: Defining analytical and clinical performance characteristics for cervical cytology specimens SO GYNECOLOGIC ONCOLOGY LA English DT Article DE HPV; HPV genotyping; HPV primers; PCR; Quantitative PCR ID HUMAN-PAPILLOMAVIRUS HPV; GENERAL PRIMERS; PCR; DNA; DIVERSITY; CANCER; METAANALYSIS; PREVALENCE; GUIDELINES; EVOLUTION AB Objective. To compare the analytical and clinical performance characteristics of 3 different primer sets targeting the human papillomavirus (HPV) L1 gene for detection and genotyping of HPV. Methods. Liquid-based cytology was obtained prospectively from 90 colposcopy clinic patients. After automated extraction, cellular DNA was subjected to SYBR Green quantitative polymerase chain reaction (qPCR) using GP5+/6+ primers and conventional PCR with MY09/11 and FAP59/64 primers. The resulting SYBR Green counts and melting temperatures (T(m)) were used for quantification of HPV genomes and discrimination between presence and absence of amplicons. qPCR and PCR products were resolved by gel electrophoresis. HPV + amplicons were sequenced directly and BLAST (R) aligned for genotype identification. Results. Of the 90 samples, 57 (63%) were qPCR + with a range of HPV viral load detected from 191 to 3.4 million genomes (similar to 5 Log(10)). Only HPV-positives exhibited characteristic T(m) (75-80 degrees C). The dynamic range of detection was similar for MY and FAP. Clinical net sensitivity was highest with simultaneous testing using all primer sets (93%) instead of individual primer pairs (GP (67%), MY (62%), FAP (49%)). Of the 27 HPV genotypes identified among 64 sequenced samples, the 3 most prevalent were HPV-16 (20%), -53 (9%), -31 (6%). The 4th rank included HPV-6, -33, -58, -66 (4.7% each). Conclusion. The performance characteristics of 3 leading PCR-based HPV assays revealed qPCR to be sensitive and specific for HPV detection and quantification. Parallel PCR testing using the 3 primers and direct sequencing offered the greatest clinical sensitivity and breadth of detection for known HPV types. Published by Elsevier Inc. C1 [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, Ft Sam Houston, TX 78234 USA. RP Shen-Gunther, J (reprint author), Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM jane.shengunther@us.army.mil FU U.S. Army at Brooke Army Medical Center, Fort Sam Houston, Texas FX This work was supported by the U.S. Army Graduate Medical Education-Clinical Research Fellowship Program at Brooke Army Medical Center, Fort Sam Houston, Texas. NR 32 TC 12 Z9 12 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2011 VL 123 IS 2 BP 263 EP 271 DI 10.1016/j.ygyno.2011.07.017 PG 9 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 839ZJ UT WOS:000296407700017 PM 21839499 ER PT J AU Shen-Gunther, J Shank, JJ Ta, V AF Shen-Gunther, Jane Shank, Jessica J. Ta, Vulihn TI Gardasil (TM) HPV vaccination: Surveillance of vaccine usage and adherence in a military population SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY NOV 15-18, 2009 CL Honolulu, HI SP Amer Coll Obstetricians & Gynecologists, Armed Forces Dist DE Papillomavirus infections; Papillomavirus vaccines; Viral vaccines; Vaccination; Human papillomavirus ID HUMAN-PAPILLOMAVIRUS; COMPLETION; TIMELINESS; TRIAL AB Objectives. To investigate the usage patterns and adherence rates with the quadrivalent HPV (qHPV) vaccine at Naval Medical Center San Diego. Methods. This retrospective, cross-sectional study was conducted by using AHLTA (Electronic Health Record of DoD) to identify all qHPV recipients between 2006 and 2009. Charts were reviewed to extract demographic variables and immunization schedules for association analysis. Subjects were assigned intention-to-treat (ITT) if they initiated the series and reached the 1-year anniversary after dose-1 or in-progress (IP) if the series was incomplete and within 1-year. ITT subjects were designated non-adherent or adherent based on 1-2 or 3 doses received. Results. 6792 females and 46 males with respective mean ages (years) of 19 (95% Cl: 10-29) and 27 (95% Cl: 946) initiated the qHPV series. The evaluable ITT population consisted of 5088 females and 31 males. The adherence rate for females was 32% (1656/5088) versus 3% (1/31) for males. For females, adherence declined from 45%, 24%, to 14% with respect to increasing age: 8-17, 18-26,27-50 years. Adherence declined accordingly by beneficiary status: dependent daughters (43%), spouses (21%) and active duty (16%); and by clinic of vaccine initiation: Pediatrics/Adolescent (45%), Primary Care (38%), Immunization (21%), and OB/GYN (9%). Males were predominantly active duty 84%, vaccinated through immunization clinics 84%, and poorly adherent 3%. Conclusions. Optimal HPV immunization efficacy is derived from vaccine adherence and HPV naivety. This study of qHPV adherence has provided insight into real-world suboptimal use post-marketing. Usage pattems and adherence rates were significantly associated with demographic characteristics. Published by Elsevier Inc. C1 [Shen-Gunther, Jane] USN, Gynecol Oncol Serv, San Diego Med Ctr, San Diego, CA 92152 USA. [Shank, Jessica J.] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA. [Ta, Vulihn] USN, Hosp Twentynine Palms, Dept Obstet & Gynecol, Twentynine Palms, CA USA. RP Shen-Gunther, J (reprint author), Brooke Army Med Ctr, Dept Clin Invest, ATTN MCHE CI, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM jane.shengunther@us.army.mil NR 28 TC 8 Z9 8 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2011 VL 123 IS 2 BP 272 EP 277 DI 10.1016/j.ygyno.2011.07.094 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 839ZJ UT WOS:000296407700018 PM 21864887 ER PT J AU Torres, DM Jones, FJ Shaw, JC Williams, CD Ward, JA Harrison, SA AF Torres, Dawn M. Jones, Frances J. Shaw, Janet C. Williams, Christopher D. Ward, John A. Harrison, Stephen A. TI Rosiglitazone Versus Rosiglitazone and Metformin Versus Rosiglitazone and Losartan in the Treatment of Nonalcoholic Steatohepatitis in Humans: A 12-Month Randomized, Prospective, Open-Label Trial SO HEPATOLOGY LA English DT Article ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; TYPE-1 RECEPTOR BLOCKER; HISTOLOGICAL SEVERITY; INSULIN SENSITIVITY; VITAMIN-E; FIBROSIS; PIOGLITAZONE; TELMISARTAN; RISK AB Medication combinations that improve the efficacy of thiazolidinediones or ameliorate weight-gain side effects of therapy represent an attractive potential treatment for (NASH). The aim of this randomized, open-label trial was to assess the efficacy of rosiglitazone and metformin in combination versus rosiglitazone and losartan, compared to rosiglitazone alone, after 48 weeks of therapy. A total of 137 subjects with biopsy-proven NASH were enrolled and randomly assigned to receive either 4 mg twice-daily of rosiglitazone, 4 mg of rosiglitazone and 500 mg of metformin twice-daily, or 4 mg of rosiglitazone twice-daily and 50 mg of losartan once-daily for 48 weeks. Patients were screened for other etiologies of chronic liver disease, including daily alcohol intake in excess of 20 g. Repeat liver biopsy was performed after 48 weeks of therapy and reviewed in a blinded fashion by a single expert hepatopathologist. The primary aim of the study was to assess for differences between treatment groups in the improvement of steatosis, hepatocellular inflammation, and fibrosis. In total, 108 subjects completed the trial. Primary outcome revealed no significant difference between treatment groups in all histologic parameters (steatosis, P 5 0.137; hepatocellular inflammation, P = 0.320; fibrosis, P = 0.229). Overall improvement in steatosis, hepatocellular inflammation, ballooning degeneration, and fibrosis was observed (P <= 0.001). Serum aminotransferases were reduced in all three groups (P < 0.001 within treatment, P > 0.05 between groups). Metformin did not significantly mitigate weight gain (P = 0.051). Conclusions: Forty-eight weeks of combination therapy with rosiglitazone and metformin or rosiglitazone and losartan confers no greater benefit than rosiglitazone alone with respect to histopathology. (HEPATOLOGY 2011;54:1631-1639) C1 [Torres, Dawn M.] Walter Reed Army Med Ctr, Dept Med, Div Gastroenterol, Washington, DC 20307 USA. [Jones, Frances J.; Williams, Christopher D.] Wilford Hall USAF Med Ctr, Dept Med, Div Gastroenterol, San Antonio, TX USA. [Shaw, Janet C.] Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX USA. [Ward, John A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil FU Mochida; Rottapharm FX Dr. Harrison advises Amylin. He received grants from Mochida and Rottapharm. Dr. Williams is on the speakers' bureau of Vertex and Kadman. NR 31 TC 61 Z9 62 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD NOV PY 2011 VL 54 IS 5 BP 1631 EP 1639 DI 10.1002/hep.24558 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 840LX UT WOS:000296443100017 PM 21748770 ER PT J AU Gobern, JM Novak, CM Lockrow, EG AF Gobern, Joseph M. Novak, Christopher M. Lockrow, Ernest G. TI Survey of Robotic Surgery Training in Obstetrics and Gynecology Residency SO JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY LA English DT Article DE Resident; Robotic surgery; Robotic training ID TOTAL LAPAROSCOPIC HYSTERECTOMY; SURGICAL OUTCOMES AB To examine the status of resident training in robotic surgery in obstetrics and gynecology programs in the United States, an online survey was emailed to residency program directors of 247 accredited programs identified through the Accreditation Council for Graduate Medical Education website. Eighty-three of 247 program directors responded, representing a 34% response rate. Robotic surgical systems for gynecologic procedures were used at 65 (78%) institutions. Robotic surgery training was part of residency curriculum at 48 (58%) residency programs. Half of respondents were undecided on training effectiveness. Most program directors believed the role of robotic surgery would increase and play a more integral role in gynecologic surgery. Robotic surgery was widely reported in residency training hospitals with limited availability of effective resident training. Robotic surgery training in obstetrics and gynecology residency needs further assessment and may benefit from a structured curriculum. Journal of Minimally Invasive Gynecology (2011) 18,755-760 Published by Elsevier Inc. on behalf of AAGL. C1 [Gobern, Joseph M.; Lockrow, Ernest G.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Novak, Christopher M.] Uniformed Serv Univ Hlth Sci, Uniformed Serv Residency Obstet & Gynecol, Natl Capital Consortium, Bethesda, MD 20814 USA. RP Gobern, JM (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Joseph.m.gobern@us.army.mil NR 19 TC 14 Z9 14 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1553-4650 J9 J MINIM INVAS GYN JI J. Mimim. Invasive Gynecol. PD NOV-DEC PY 2011 VL 18 IS 6 BP 755 EP 760 DI 10.1016/j.jmig.2011.08.004 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 846ZQ UT WOS:000296942100013 PM 22024262 ER EF