FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Somerville, SM
   Gordon, RK
AF Somerville, Shahza M.
   Gordon, Richard K.
TI The effect of the pro-drug of 2-PAM, pro-2-PAM, on SH-SY5Y Neuroblastoma
   Cells
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Somerville, Shahza M.; Gordon, Richard K.] Walter Reed Army Inst Res, DRA, Regulated Labs, Silver Spring, MD USA.
NR 0
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U1 0
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PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708404731
ER

PT J
AU Srinivasan, S
   Bintu, S
   Miller, SA
   Muhie, S
   Hammamieh, R
   Meyerhoff, J
   Jett, M
AF Srinivasan, Seshamalini
   Bintu, Sowe
   Miller, Stacy-Ann
   Muhie, Seid
   Hammamieh, Rasha
   Meyerhoff, James
   Jett, Marti
TI Studying the epigenetic regulations of posttraumatic stress disorder
   (PTSD) using a social defeat mouse model
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Srinivasan, Seshamalini; Bintu, Sowe; Miller, Stacy-Ann; Muhie, Seid; Hammamieh, Rasha; Meyerhoff, James; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 2
U2 4
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708402617
ER

PT J
AU Stauss, HM
   Liaboe, FO
   Ingram, R
   Leon, LR
   Kregel, KC
AF Stauss, Harald Martin
   Liaboe, Frederick O.
   Ingram, Robert
   Leon, Lisa R.
   Kregel, Kevin C.
TI Cardiovascular, thermoregulatory, and autonomic effects of pretreatment
   with clonidine (C) or lisinopril (L) on recovery from exertional heat
   stress (ExHs) in rats
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Stauss, Harald Martin; Liaboe, Frederick O.; Ingram, Robert; Kregel, Kevin C.] Univ Iowa, Iowa City, IA USA.
   [Leon, Lisa R.] USA, Thermal Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708400753
ER

PT J
AU Stote, KS
   Carrico, P
   Cole, R
AF Stote, Kim S.
   Carrico, Pauline
   Cole, Renee
TI Assessing adults' dietary intake, utilizing the National Cancer
   Institute's automated self-administered 24-hour dietary recall, in
   virtual learning environments
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Stote, Kim S.; Carrico, Pauline] SUNY Empire State Coll, Saratoga Springs, NY 12866 USA.
   [Cole, Renee] USA, Acad Hlth Sci, Med Dept Ctr, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708403286
ER

PT J
AU Tharion, WJ
   Buller, MJ
   Karis, AJ
   Yokota, M
   Hoyt, RW
AF Tharion, William J.
   Buller, Mark J.
   Karis, Anthony J.
   Yokota, Miyo
   Hoyt, Reed W.
TI Seasonal differences in the performance and physiology of participants
   in a physically demanding military road march
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Tharion, William J.; Buller, Mark J.; Karis, Anthony J.; Yokota, Miyo; Hoyt, Reed W.] USA, Biophys & Biomed Modeling Div, Environm Med Res Inst, Natick, MA 01760 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708400757
ER

PT J
AU Uyehara, CFT
   Sato, AK
   Murata, LA
   Hernandez, CA
   Wong, TJ
   Ichimura, WM
AF Uyehara, Catherine F. T.
   Sato, Aileen K.
   Murata, Lee-Ann
   Hernandez, Claudia A.
   Wong, Thomas J.
   Ichimura, Wayne M.
TI Vasopressin Pituitary Stores Acutely Released in Vasodilatory and
   Hypovolemic Shock Are Not Immediately Restored With Prolonged
   Hypotension
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Uyehara, Catherine F. T.; Sato, Aileen K.; Murata, Lee-Ann; Hernandez, Claudia A.; Wong, Thomas J.; Ichimura, Wayne M.] Tripler Army Med Ctr, Dept Clin Investigat, Tripler, HI USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708401096
ER

PT J
AU Wang, XY
   Bynum, J
   Bowman, PD
AF Wang, Xinyu
   Bynum, James
   Bowman, Phillip D.
TI Time Course and Network Analysis of
   1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidizole (CDDO-IM)
   Induction of Cytoprotective Genes in Human Umbilical Vein Endothelial
   Cells (HUVEC) Against Oxidant Stress
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Wang, Xinyu] PCOM Sch Pharm, Suwanee, GA USA.
   [Bynum, James; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708401196
ER

PT J
AU Ward, JA
   DeLorenzo, RA
   Rubal, BJ
   Jordan, BS
   Medina, JS
   Holbrook-Emmons, VL
   Hanson, CE
AF Ward, John A.
   DeLorenzo, Robert A.
   Rubal, Bernard J.
   Jordan, Bryan S.
   Medina, Juanita S.
   Holbrook-Emmons, Victoria L.
   Hanson, Chris E.
TI Phase relationships between mean arterial pressure and intraosseous (IO)
   pressure
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Ward, John A.; DeLorenzo, Robert A.; Rubal, Bernard J.; Medina, Juanita S.; Holbrook-Emmons, Victoria L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
   [Jordan, Bryan S.; Hanson, Chris E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708403797
ER

PT J
AU Zindel, K
   Wiewel, K
   McGivern, M
   Mendis, C
   Jett, M
AF Zindel, Kristin
   Wiewel, Kurstin
   McGivern, Meghan
   Mendis, Chanaka
   Jett, Marti
TI Early Intervention by Targeting inhibitors of Multiple Signal
   Transduction Pathways in LPS induced Human PBMCs
SO FASEB JOURNAL
LA English
DT Meeting Abstract
CT Experimental Biology Meeting 2011
CY APR 09-13, 2011
CL Washington, DC
SP Amer Assoc Anatomists (AAA), Amer Physiolog Soc (APS), Amer Soc Biochem & Mol Biol (ASBMB), Amer Soc Investigat Pathol (ASIP), Amer Soc Nutrit (ASN), Amer Soc Pharmacol & Expt Therapeut (ASPET)
C1 [Zindel, Kristin; Wiewel, Kurstin; McGivern, Meghan; Mendis, Chanaka] Univ Wisconsin Platteville, Platteville, WI USA.
   [Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2011
VL 25
PG 1
WC Biochemistry & Molecular Biology; Biology; Cell Biology
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 032IE
UT WOS:000310708406732
ER

PT J
AU Burtnick, MN
   Brett, PJ
   Harding, SV
   Ngugi, SA
   Ribot, WJ
   Chantratita, N
   Scorpio, A
   Milne, TS
   Dean, RE
   Fritz, DL
   Peacock, SJ
   Prior, JL
   Atkins, TP
   DeShazer, D
AF Burtnick, Mary N.
   Brett, Paul J.
   Harding, Sarah V.
   Ngugi, Sarah A.
   Ribot, Wilson J.
   Chantratita, Narisara
   Scorpio, Angelo
   Milne, Timothy S.
   Dean, Rachel E.
   Fritz, David L.
   Peacock, Sharon J.
   Prior, Joanne L.
   Atkins, Timothy P.
   DeShazer, David
TI The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant
   in Burkholderia pseudomallei
SO INFECTION AND IMMUNITY
LA English
DT Article
ID RAW-264.7 MURINE MACROPHAGES; MALLEI; MELIOIDOSIS; CELLS; MUTANTS;
   IDENTIFICATION; MUTAGENESIS; EXPRESSION; GLANDERS; BACTERIA
AB The Burkholderia pseudomallei K96243 genome encodes six type VI secretion systems (T6SSs), but little is known about the role of these systems in the biology of B. pseudomallei. In this study, we purified recombinant Hcp proteins from each T6SS and tested them as vaccine candidates in the BALB/c mouse model of melioidosis. Recombinant Hcp2 protected 80% of mice against a lethal challenge with K96243, while recombinant Hcp1, Hcp3, and Hcp6 protected 50% of mice against challenge. Hcp6 was the only Hcp constitutively produced by B. pseudomallei in vitro; however, it was not exported to the extracellular milieu. Hcp1, on the other hand, was produced and exported in vitro when the VirAG two-component regulatory system was overexpressed in trans. We also constructed six hcp deletion mutants (Delta hcp1 through Delta hcp6) and tested them for virulence in the Syrian hamster model of infection. The 50% lethal doses (LD(50)s) for the Delta hcp2 through Delta hcp6 mutants were indistinguishable from K96243 (< 10 bacteria), but the LD50 for the Delta hcp1 mutant was > 10(3) bacteria. The hcp1 deletion mutant also exhibited a growth defect in RAW 264.7 macrophages and was unable to form multinucleated giant cells in this cell line. Unlike K96243, the Delta hcp1 mutant was only weakly cytotoxic to RAW 264.7 macrophages 18 h after infection. The results suggest that the cluster 1 T6SS is essential for virulence and plays an important role in the intracellular lifestyle of B. pseudomallei.
C1 [Ribot, Wilson J.; Fritz, David L.; DeShazer, David] USA, Bacteriol Div, MRIID, Frederick, MD 21702 USA.
   [Burtnick, Mary N.; Brett, Paul J.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA.
   [Harding, Sarah V.; Ngugi, Sarah A.; Milne, Timothy S.; Dean, Rachel E.; Prior, Joanne L.; Atkins, Timothy P.] Def Sci & Technol Lab, Dept Biomed Sci, Salisbury SP4 0JQ, Wilts, England.
   [Chantratita, Narisara] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, Bangkok, Thailand.
   [Chantratita, Narisara] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand.
   [Scorpio, Angelo] Natl Biodef Anal & Countermeasures Ctr, Frederick, MD 21702 USA.
   [Peacock, Sharon J.] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QQ, England.
RP DeShazer, D (reprint author), USA, Bacteriol Div, MRIID, Frederick, MD 21702 USA.
EM david.deshazer@us.army.mil
FU Defense Threat Reduction Agency (DTRA)/Joint Science and Technology
   Office for Chemical and Biological Defense (JSTO-CBD) [2.10018_06_RD_B];
   UK Ministry of Defense; DTRA/JSTO-CBD [CBS.MEDBIO.02.10.RD.034]; U.S.
   Department of Homeland Security for the management and operation of the
   National Biodefense Analysis and Countermeasures Center (NBACC)
   [HSHQDC-07-C-00020]
FX D.D. conducted research on this project at Dstl Porton Down for 9 months
   as part of The Technical Cooperation Program (TTCP). The sabbatical
   leave and research was funded by the Defense Threat Reduction Agency
   (DTRA)/Joint Science and Technology Office for Chemical and Biological
   Defense (JSTO-CBD) (proposal number 2.10018_06_RD_B) and by the UK
   Ministry of Defense. This project also received support from
   DTRA/JSTO-CBD proposal number CBS.MEDBIO.02.10.RD.034 (to D.D.) and
   agreement no. HSHQDC-07-C-00020 awarded by the U.S. Department of
   Homeland Security for the management and operation of the National
   Biodefense Analysis and Countermeasures Center (NBACC).
NR 42
TC 97
Z9 101
U1 4
U2 29
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
EI 1098-5522
J9 INFECT IMMUN
JI Infect. Immun.
PD APR
PY 2011
VL 79
IS 4
BP 1512
EP 1525
DI 10.1128/IAI.01218-10
PG 14
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 736YX
UT WOS:000288532300013
PM 21300775
ER

PT J
AU Man, YG
   Mason, J
   Harley, R
   Kim, YH
   Zhu, K
   Gardner, WA
AF Man, Yan-gao
   Mason, Jeffrey
   Harley, Russell
   Kim, Yeon Ho
   Zhu, Kangmin
   Gardner, William A.
TI Leukocyte-Mediated Cell Dissemination and Metastasis: Findings From
   Multiple Types of Human Tumors
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE TUMOR METASTASIS; TUMOR INVASION; TUMOR STEM CELL; LYMPHOCYTES;
   LEUKOCYTES; INTERCELLULAR JUNCTIONS; SURFACE ADHESION MOLECULES
ID RESULTANT AUTO-IMMUNOREACTIONS; CANCER STEM-CELLS; BREAST-CANCER; FOCAL
   DEGENERATION; LAYER DISRUPTIONS; MAMMARY-TUMORS; INVASION; PROGRESSION;
   INFILTRATION; MACROPHAGES
AB Our previous studies revealed that leukocyte infiltration could trigger human breast and prostate tumor invasion through focal disruptions of the tumor capsule, which selectively favors monoclonal proliferation of tumor progenitors or a biologically more aggressive cell clone overlying the focal disruptions. Our current study, involving multiple types of human tumors, further shows that leukocyte infiltration could also trigger tumor metastasis through the following pathways: [1] more leukocytes migrate to focally disrupted tumor capsules, which forms leukocyte aggregates surrounding newly formed tumor cell clusters, [2] the physical movement of leukocytes into proliferating tumor cells disrupts the intercellular junctions and cell-surface adhesion molecules, causing the disassociation of tumor cells from the tumor core, [3] leukocytes are conjoined with some of these tumor cells through plasma membrane fusion, creating tumor cell-leukocyte chimeras (TLCs), and [4] the leukocyte of TLCs impart migratory capacity to associated tumor cell partners, physically dragging them to different tissue sites. Our findings suggest a novel pathway for tumor cell dissemination from the primary sites and the subsequent journey to new sites. Our findings also provide a unique explanation for the cellular mechanism of leukocytes on tumor invasion and metastasis. If confirmed, our hypothesis and technical approach may significantly facilitate early detection and intervention of tumor invasion and metastasis. J. Cell. Biochem. 112: 1154-1167, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Man, Yan-gao] Armed Forces Inst Pathol, Dept Gynecol & Breast Pathol, Washington, DC 20306 USA.
   [Man, Yan-gao; Mason, Jeffrey; Harley, Russell; Gardner, William A.] Amer Registry Pathol, Washington, DC 20306 USA.
   [Kim, Yeon Ho] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20306 USA.
   [Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20850 USA.
   [Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20850 USA.
RP Man, YG (reprint author), Armed Forces Inst Pathol, Dept Gynecol & Breast Pathol, 6825 16th St, Washington, DC 20306 USA.
EM man@afip.osd.mil
FU Congressionally Medical Research Programs [DAMD17-01-1-0129,
   DAMD17-01-1-0130, PC051308]; Susan G. Komen Breast Cancer Foundation
   [BCTR0706983]; Ministry of Chinese Science and Technology Department
   [2006CB910505]; US Military Cancer Institute; Henry M. Jackson
   Foundation [2008-02]
FX Grant sponsor: Congressionally Medical Research Programs; Grant numbers:
   DAMD17-01-1-0129, DAMD17-01-1-0130, PC051308; Grant sponsor: The Susan
   G. Komen Breast Cancer Foundation; Grant number: BCTR0706983; Grant
   sponsor: Ministry of Chinese Science and Technology Department; Grant
   number: 2006CB910505; Grant sponsor: US Military Cancer Institute and
   Henry M. Jackson Foundation; Grant number: 2008-02.
NR 40
TC 13
Z9 13
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD APR
PY 2011
VL 112
IS 4
BP 1154
EP 1167
DI 10.1002/jcb.23035
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 735DQ
UT WOS:000288394000017
PM 21312236
ER

PT J
AU Taylor, JC
   Gauer, R
   Rideout, S
AF Taylor, Jonathan C.
   Gauer, Robert
   Rideout, Stacy
TI Ureteral calculi: What should you consider before intervening?
SO JOURNAL OF FAMILY PRACTICE
LA English
DT Editorial Material
ID PASSAGE
C1 [Taylor, Jonathan C.; Gauer, Robert] Womack Family Med Residency Clin, Ft Bragg, NC USA.
   [Rideout, Stacy] Wake Area Hlth Educ Ctr, Med Lib, Raleigh, NC USA.
RP Taylor, JC (reprint author), Womack Family Med Residency Clin, Ft Bragg, NC USA.
NR 4
TC 0
Z9 0
U1 0
U2 1
PU DOWDEN HEALTH MEDIA
PI MONTVALE
PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA
SN 0094-3509
J9 J FAM PRACTICE
JI J. Fam. Pract.
PD APR
PY 2011
VL 60
IS 4
BP 232
EP 233
PG 2
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 930II
UT WOS:000303131900014
PM 21472155
ER

PT J
AU Kim, A
   Hartman, I
   Lanar, D
   Boronina, T
   Cole, R
   Sadegh-Nasseri, S
AF Kim, Ae
   Hartman, Isamu
   Lanar, David
   Boronina, Tatiana
   Cole, Robert
   Sadegh-Nasseri, Scheherazade
TI Presentation of immunodominant epitopes from mixture of protein antigens
   is hierarchial
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Kim, Ae; Sadegh-Nasseri, Scheherazade] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA.
   [Hartman, Isamu] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
   [Lanar, David] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA.
   [Boronina, Tatiana] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA.
   [Cole, Robert] Johns Hopkins Univ, Sch Med, Inst Basic Biomed Sci, Mass Spectrometry & Prote Facil, Baltimore, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR
PY 2011
VL 186
SU 1
MA 100.21
PG 2
WC Immunology
SC Immunology
GA V44LY
UT WOS:000209751703054
ER

PT J
AU Moser, J
   Sassano, E
   Muerrle, C
   Waag, D
   Wittman, V
AF Moser, Janice
   Sassano, Emily
   Muerrle, Christopher
   Waag, David
   Wittman, Vaughan
TI Analysis of a live attenuated bacterial vaccine for tularemia in the
   MIMIC (R) (Modular Immune In vitro Construct) System
SO JOURNAL OF IMMUNOLOGY
LA English
DT Meeting Abstract
C1 [Moser, Janice; Sassano, Emily; Muerrle, Christopher; Wittman, Vaughan] Sanofi Pasteur VaxDesign Campus, Orlando, FL USA.
   [Waag, David] US Army Med Res Inst Infect Dis, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR
PY 2011
VL 186
SU 1
MA 52.6
PG 1
WC Immunology
SC Immunology
GA V44LY
UT WOS:000209751701015
ER

PT J
AU Gilbert, PB
   Berger, JO
   Stablein, D
   Becker, S
   Essex, M
   Hammer, SM
   Kim, JH
   DeGruttola, VG
AF Gilbert, Peter B.
   Berger, James O.
   Stablein, Donald
   Becker, Stephen
   Essex, Max
   Hammer, Scott M.
   Kim, Jerome H.
   DeGruttola, Victor G.
TI Statistical Interpretation of the RV144 HIV Vaccine Efficacy Trial in
   Thailand: A Case Study for Statistical Issues in Efficacy Trials
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID RANDOMIZED CLINICAL-TRIALS; COVARIATE ADJUSTMENT; DOUBLE-BLIND;
   EFFICIENCY; INFECTION; ALVAC
AB Recently, the RV144 randomized, double-blind, efficacy trial in Thailand reported that a prime-boost human immunodeficiency virus (HIV) vaccine regimen conferred similar to 30% protection against HIV acquisition. However, different analyses seemed to give conflicting results, and a heated debate ensued as scientists and the broader public struggled with their interpretation. The lack of accounting for statistical principles helped flame the debate, and we leverage these principles to provide a more scientific interpretation. We first address interpretation of frequentist results, including interpretation of P values, synthesis of results from multiple analyses (ie, intention-to-treat versus per-protocol/fully immunized), and accounting for external efficacy trials. Second, we address how Bayesian statistics, which provide clearly interpretable statements about probabilities that the vaccine efficacy takes certain values, provide more information for weighing the evidence about efficacy than do frequentist statistics alone. Third, we evaluate RV144 for completeness of end point ascertainment and integrity of blinding, necessary tasks for establishing robustly interpretable results.
C1 [Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine Infect Dis Div, Seattle, WA 98109 USA.
   [Gilbert, Peter B.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
   [Becker, Stephen] Bill & Melinda Gates Fdn, Seattle, WA USA.
   [Berger, James O.] Duke Univ, Dept Stat Sci, Durham, NC USA.
   [Stablein, Donald] EMMES Corp, Rockville, MD USA.
   [Kim, Jerome H.] US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Dept Mol Virol & Pathogenesis, Rockville, MD USA.
   [Essex, Max] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Harvard Sch Publ Hlth AIDS Initiat, Boston, MA 02115 USA.
   [DeGruttola, Victor G.] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
   [Hammer, Scott M.] Columbia Univ, Coll Phys & Surg, Div Infect Dis, New York, NY USA.
RP Gilbert, PB (reprint author), Fred Hutchinson Canc Res Ctr, Vaccine Infect Dis Div, 1100 Fairview Ave N,POB 19024, Seattle, WA 98109 USA.
EM pgilbert@scharp.org
RI Berger, James/C-6067-2013
OI Berger, James/0000-0002-6413-2876
FU National Institutes of Health [2R37AI054165-08, UO1 AI069470]; National
   Science Foundation [DMS-1007773]; U.S. Army Medical Research and
   Materiel Command (USAMRMC) [Y1-AI-2642-15]; National Institutes of
   Allergy and Infectious Diseases [Y1-AI-2642-15]; Henry M. Jackson
   Foundation for the Advancement of Military Medicine, Inc.
   [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]
FX P.B.G. and S. M. H. were supported by the National Institutes of Health
   (2R37AI054165-08 and UO1 AI069470, respectively). J.O.B. was supported
   by National Science Foundation (DMS-1007773). USMHRP (J.H.K., D. M. S.)
   is supported in part by an Interagency Agreement Y1-AI-2642-15 between
   U.S. Army Medical Research and Materiel Command (USAMRMC) and the
   National Institutes of Allergy and Infectious Diseases. In addition this
   work was supported by a cooperative agreement (W81XWH-07-2-0067) between
   the Henry M. Jackson Foundation for the Advancement of Military
   Medicine, Inc., and the U.S. Department of Defense (DOD).
NR 29
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U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD APR 1
PY 2011
VL 203
IS 7
BP 969
EP 975
DI 10.1093/infdis/jiq152
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 737FF
UT WOS:000288553800012
PM 21402548
ER

PT J
AU Zhou, J
   Enewold, L
   Peoples, GE
   McLeod, DG
   Potter, JF
   Steele, SR
   Clive, KS
   Stojadinovic, A
   Zhu, KM
AF Zhou, Jing
   Enewold, Lindsey
   Peoples, George E.
   McLeod, David G.
   Potter, John F.
   Steele, Scott R.
   Clive, Kevin S.
   Stojadinovic, Alexander
   Zhu, Kangmin
TI Colorectal, Prostate, and Skin Cancer Screening Among Hispanic and White
   Non-Hispanic Men, 2000-2005
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE cancer; screening; Latinos; men's health; health promotion; endoscopy
ID SERVICES TASK-FORCE; HEALTH INTERVIEW SURVEY; PREVENTIVE SERVICES;
   UNITED-STATES; ETHNIC-GROUPS; ANTIGEN TEST; DISPARITIES; RISK;
   SURVEILLANCE; INFORMATION
AB Background: Hispanic men have lower colorectal, prostate, and skin cancer screening rates than white non-Hispanic men. Programs designed to increase screening rates, including the national Screen for Life campaign specifically for promoting colorectal cancer (CRC) screening, regional educational/research programs, and state cancer control programs, have been launched. Screen for Life and some intervention programs included educational materials in Spanish as well as English.
   Objective: To assess whether CRC as well as prostate and skin cancer screening rates among Hispanic and white non-Hispanic men changed between 2000 and 2005. Methods: Cancer screening rates were compared between 2000 and 2005 using the National Health Interview Survey data. The age ranges of the study subjects and definitions of cancer screening were site specific and based on the American Cancer Society recommendations.
   Results: Hispanic men were less likely to comply with cancer screening guidelines than white non-Hispanic men. However, significant increases in CRC endoscopic screening were observed in both ethnic groups. It increased 2.1-fold and 2.4-fold for Hispanics and white non-Hispanics, respectively (P < .05). In contrast, the use of home fecal occult blood tests decreased among white non-Hispanics but remained similar among Hispanics. Prostate-specific antigen screening remained stable, while the use of skin cancer screening tended to increase among both groups.
   Conclusion: Although cancer screening rates may be affected by multiple factors, our study suggested the intervention programs such as the Centers for Disease Control and Prevention's national Screen for Life campaign may have raised CRC screening awareness and may contributed to the increase in endoscopic screening rates among both ethnic groups.
C1 [Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
   [Zhou, Jing; Enewold, Lindsey; Potter, John F.; Zhu, Kangmin] US Mil Canc Inst, Washington, DC USA.
   [Peoples, George E.; Clive, Kevin S.] Ft Sam, Brooke Army Med Ctr, Houston, TX USA.
   [McLeod, David G.; Stojadinovic, Alexander] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   [Steele, Scott R.] Madigan Army Med Ctr, Washington, DC USA.
RP Zhu, K (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM kangmin.zhu@amedd.army.mil
FU US Military Cancer Institute via the Uniformed Services University of
   the Health Sciences under the auspices of the Henry M. Jackson
   Foundation for the Advancement of Military Medicine
FX This research was supported by the US Military Cancer Institute via the
   Uniformed Services University of the Health Sciences under the auspices
   of the Henry M. Jackson Foundation for the Advancement of Military
   Medicine.
NR 52
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U1 2
U2 4
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD APR
PY 2011
VL 103
IS 4
BP 343
EP 350
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 781DW
UT WOS:000291911800006
PM 21805813
ER

PT J
AU Shah, A
   Shah, S
   Mani, G
   Wenke, J
   Agrawal, M
AF Shah, Amita
   Shah, Sarita
   Mani, Gopinath
   Wenke, Joseph
   Agrawal, Mauli
TI Endothelial cell behaviour on gas-plasma-treated PLA surfaces: the roles
   of surface chemistry and roughness
SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
LA English
DT Article
DE endothelial cells; polylactic acid; gas-plasma treatment; surface
   characterization; cell viability; cell attachment
ID GLOW-DISCHARGE; FUNCTIONAL-GROUPS; POLY D,L-LACTIDE; ADHESION; OXYGEN;
   SCAFFOLDS; POLYTETRAFLUOROETHYLENE; BIOCOMPATIBILITY; WETTABILITY;
   ADSORPTION
AB Glow-discharge gas-plasma (GP) treatment has been shown to induce surface modifications such that cell adhesion and growth are enhanced. However, it is not known which gas used in GP treatment is optimal for endothelial cell function. Polylactic acid (PLA) films treated oxygen, argon, or nitrogen GP were characterized using contact angles, scanning electron microscopy, atomic force microscopy, optical profilometry, and x-ray photoelectron spectroscopy. All three GP treatments decreased the carbon atomic concentration and surface roughness and increased the oxygen atomic concentration. Human umbilical vein endothelial cells were cultured on the PLA films for up to 7 days. Based on proliferation and live/dead assays, surface chemistry was shown to have the greatest effect on the attachment, proliferation, and viability of these cells, while roughness did not have a significant influence. Of the different gases, endothelial cell viability, attachment and proliferation were most significantly increased on PLA surfaces treated with oxygen and argon gas plasma. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Shah, Amita; Mani, Gopinath; Agrawal, Mauli] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA.
   [Shah, Amita; Shah, Sarita; Wenke, Joseph] USA, Dept Regenerat Med, Inst Surg Res, San Antonio, TX USA.
   [Shah, Amita] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78229 USA.
RP Agrawal, M (reprint author), Univ Texas San Antonio, Dept Biomed Engn, 1 UTSA Circle, San Antonio, TX 78249 USA.
EM mauli.agrawal@utsa.edu
FU Department of the Army [W81XWH-07-1-0717]; US Army Medical Research
   Acquisition Activity
FX Special thanks to Dr Denes Marton for performing XPS and Dr Joel
   Michalek for performing the proliferation study statistical analysis.
   Optical profilometry was performed at the University of Colorado-CAPT
   Laboratory. Work for this study was sponsored by the Department of the
   Army (Grant No. W81XWH-07-1-0717). The US Army Medical Research
   Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014,
   USA, is the awarding and administering acquisition office. The opinions
   or assertions contained herein are the private views of the authors and
   are not to be construed as official or as reflecting the views of the
   Department of the Army or the Department of Defense.
NR 26
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U1 4
U2 23
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1932-6254
J9 J TISSUE ENG REGEN M
JI J. Tissue Eng. Regen. Med.
PD APR
PY 2011
VL 5
IS 4
BP 301
EP 312
DI 10.1002/term.316
PG 12
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
   Biology; Engineering, Biomedical
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering
GA 737HD
UT WOS:000288558800012
PM 21413158
ER

PT J
AU Basu, A
   Li, B
   Mills, DM
   Panchal, RG
   Cardinale, SC
   Butler, MM
   Peet, NP
   Majgier-Baranowska, H
   Williams, JD
   Patel, I
   Moir, DT
   Bavari, S
   Ray, R
   Farzan, MR
   Rong, LJ
   Bowlin, TL
AF Basu, Arnab
   Li, Bing
   Mills, Debra M.
   Panchal, Rekha G.
   Cardinale, Steven C.
   Butler, Michelle M.
   Peet, Norton P.
   Majgier-Baranowska, Helena
   Williams, John D.
   Patel, Ishan
   Moir, Donald T.
   Bavari, Sina
   Ray, Ranjit
   Farzan, Michael R.
   Rong, Lijun
   Bowlin, Terry L.
TI Identification of a Small-Molecule Entry Inhibitor for Filoviruses
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID EBOLA-VIRUS GLYCOPROTEIN; HEMORRHAGIC-FEVER ARENAVIRUSES; RESPIRATORY
   SYNCYTIAL VIRUS; FOLATE RECEPTOR-ALPHA; DENDRITIC CELLS; MEASLES-VIRUS;
   ENDOTHELIAL-CELLS; MAMMALIAN-CELLS; TARGET SITE; VIRAL ENTRY
AB Ebola virus (EBOV) causes severe hemorrhagic fever, for which therapeutic options are not available. Preventing the entry of EBOV into host cells is an attractive antiviral strategy, which has been validated for HIV by the FDA approval of the anti-HIV drug enfuvirtide. To identify inhibitors of EBOV entry, the EBOV envelope glycoprotein (EBOV-GP) gene was used to generate pseudotype viruses for screening of chemical libraries. A benzodiazepine derivative (compound 7) was identified from a high-throughput screen (HTS) of small-molecule compound libraries utilizing the pseudotype virus. Compound 7 was validated as an inhibitor of infectious EBOV and Marburg virus (MARV) in cell-based assays, with 50% inhibitory concentrations (IC(50)s) of 10 mu M and 12 mu M, respectively. Time-of-addition and binding studies suggested that compound 7 binds to EBOV-GP at an early stage during EBOV infection. Preliminary Schrodinger SiteMap calculations, using a published EBOV-GP crystal structure in its prefusion conformation, suggested a hydrophobic pocket at or near the GP1 and GP2 interface as a suitable site for compound 7 binding. This prediction was supported by mutational analysis implying that residues Asn69, Leu70, Leu184, Ile185, Leu186, Lys190, and Lys191 are critical for the binding of compound 7 and its analogs with EBOV-GP. We hypothesize that compound 7 binds to this hydrophobic pocket and as a consequence inhibits EBOV infection of cells, but the details of the mechanism remain to be determined. In summary, we have identified a novel series of benzodiazepine compounds that are suitable for optimization as potential inhibitors of filoviral infection.
C1 [Basu, Arnab; Li, Bing; Mills, Debra M.; Cardinale, Steven C.; Butler, Michelle M.; Peet, Norton P.; Majgier-Baranowska, Helena; Williams, John D.; Patel, Ishan; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA.
   [Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
   [Ray, Ranjit] St Louis Univ, Dept Internal Med, St Louis, MO 63110 USA.
   [Farzan, Michael R.] Harvard Univ, Sch Med, Dept Mol Biol & Genet, Southborough, MA 01772 USA.
   [Rong, Lijun] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
RP Basu, A (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA.
EM abasu@microbiotix.com
FU DHHS/NIH from the National Institutes of Health [1R43AI071450-01,
   1R01AI089590-01, 5U01AI077767-02]
FX This research was supported by DHHS/NIH grants 1R43AI071450-01,
   1R01AI089590-01, and 5U01AI077767-02 from the National Institutes of
   Health.
NR 64
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U1 0
U2 17
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD APR
PY 2011
VL 85
IS 7
BP 3106
EP 3119
DI 10.1128/JVI.01456-10
PG 14
WC Virology
SC Virology
GA 734WT
UT WOS:000288373000007
PM 21270170
ER

PT J
AU Lofts, LL
   Wells, JB
   Bavari, S
   Warfield, KL
AF Lofts, Loreen L.
   Wells, Jay B.
   Bavari, Sina
   Warfield, Kelly L.
TI Key Genomic Changes Necessary for an In Vivo Lethal Mouse Marburgvirus
   Variant Selection Process
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID MATRIX PROTEIN VP40; EBOLA-VIRUS; HEMORRHAGIC-FEVER; MESSENGER-RNA;
   MEASLES-VIRUS; ADENOSINE DEAMINASES; UNTRANSLATED REGIONS; REPLICATION;
   SEQUENCE; MICE
AB Marburgvirus (MARV) infections are generally lethal in humans and nonhuman primates but require in vivo lethal mouse variant selection by the serial transfer (passage) of the nonlethal virus into naive mice to propagate a lethal infection. The passage of progenitor (wild-type) MARV or Ravn virus (RAVV) from infected scid BALB/c mouse liver homogenates into immunocompetent BALB/c mice results in the selection of lethal mouse viruses from within the quasispecies sufficient to establish lethality in immunocompetent mice. Genomic analysis in conjunction with the passage history of each mutation detailed the altered primary and secondary structures of the viral genomic RNA throughout the process. Key findings included the following: (i) a VP40:D184N mutation previously identified in the lethal guinea pig MARV genome was the first mutation to occur during the passage of both the MARV and RAVV variants; (ii) there was biased hypermutagenesis in the RAVV variant genome; (iii) there were two identical mutations in lethal mouse MARV and RAVV variants, VP40:Y19H in the PPPY motif and VP40:D184N in a loop structure between the two VP40 domains; (iv) the passage of wild-type MARV and RAVV in mice resulted in the selection of viral variants from among the quasispecies with different genotypes than those of the wild-type viruses; and (v) a lethal mouse RAVV variant had different tissue tropisms distinct from those of its wild-type virus. These studies provide insights into how marburgviruses manipulate the host for enzymes, metabolites, translation regulators, and effectors of the innate immune response to serve as potential viral countermeasures.
C1 [Lofts, Loreen L.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA.
RP Lofts, LL (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Frederick, MD 21702 USA.
EM loreen.lofts@us.army.mil
FU USAMRIID [03-4-4J-012]; Defense Threat Reduction Agency [KK004_07_RD_B]
FX This work was supported by USAMRIID project plan number 03-4-4J-012 and
   the Defense Threat Reduction Agency (KK004_07_RD_B).
NR 51
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U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD APR
PY 2011
VL 85
IS 8
BP 3905
EP 3917
DI 10.1128/JVI.02372-10
PG 13
WC Virology
SC Virology
GA 736ZV
UT WOS:000288536100019
PM 21289122
ER

PT J
AU Douglas, TA
   Fortier, D
   Shur, YL
   Kanevskiy, MZ
   Guo, LD
   Cai, YH
   Bray, MT
AF Douglas, Thomas A.
   Fortier, Daniel
   Shur, Yuri L.
   Kanevskiy, Mikhail Z.
   Guo, Laodong
   Cai, Yihua
   Bray, Matthew T.
TI Biogeochemical and Geocryological Characteristics of Wedge and
   Thermokarst-Cave Ice in the CRREL Permafrost Tunnel, Alaska
SO PERMAFROST AND PERIGLACIAL PROCESSES
LA English
DT Article
DE permafrost; thermokarst-cave ice; organic carbon storage; Alaska
ID CRYOSTRATIGRAPHIC OBSERVATIONS; ORGANIC-CARBON; CLIMATE; FOX;
   DEGRADATION; ECOSYSTEMS; FAIRBANKS; DRAINAGE; GROWTH; ISLAND
AB Partially eroded ice wedges and lenticularly shaped bodies of massive thermokarst-cave ice in ice-rich syngenetic permafrost (yedoma) are exposed in the CRREL tunnel near Fairbanks, Alaska. The ice wedges, which formed 25 000 - 40 000 years ago, were subsequently affected by localised thermal erosion, resulting in underground cavities that filled with surface water infiltrating through a network of conduits. This water froze inward from the walls of the cavity. We report the biogeochemical characteristics of one of these thermokarst-cave ice features and four nearby ice wedges. The thermokarst-cave ice has 30 times the dissolved organic carbon concentration, 20 times the total dissolved nitrogen concentration and five to 20 times the inorganic solute concentrations of the surrounding (original) ice wedge material. Based on these results we present a schematic model to describe how the thermokarst-cave ice was formed and preserved and what processes led to its current biogeochemical characteristics. Current estimates of soluble solutes stored in permafrost may underestimate the total carbon and nutrient load where wedge material has been extensively replaced by surface water rich in organic carbon, nutrients or inorganic solutes. Published in 2011 by John Wiley & Sons, Ltd. This article is a US Government work and is in the public domain in the USA.
C1 [Douglas, Thomas A.] Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA.
   [Fortier, Daniel; Kanevskiy, Mikhail Z.] Univ Alaska, Inst No Engn, Fairbanks, AK 99701 USA.
   [Shur, Yuri L.; Bray, Matthew T.] Univ Alaska, Dept Civil & Environm Engn, Fairbanks, AK 99701 USA.
   [Guo, Laodong] Univ So Mississippi, Dept Marine Sci, Stennis Space Ctr, MS USA.
   [Cai, Yihua] Xiamen Univ, Coll Oceanog & Environm Sci, Xiamen, Fujian, Peoples R China.
RP Douglas, TA (reprint author), Cold Reg Res & Engn Lab, POB 35170, Ft Wainwright, AK 99703 USA.
EM thomas.a.douglas@usace.army.mil
RI Guo, Laodong/F-6045-2010
OI Guo, Laodong/0000-0002-5010-1630
FU National Science Foundation Office of Polar Programs [0454939]
FX The constructive comments of Hugh French, three reviewers and the Editor
   Antoni Lewkowicz greatly strengthened the manuscript. This project was
   funded by the National Science Foundation Office of Polar Programs
   (#0454939).
NR 40
TC 16
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U1 0
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1045-6740
J9 PERMAFROST PERIGLAC
JI Permafrost Periglacial Process.
PD APR-JUN
PY 2011
VL 22
IS 2
BP 120
EP 128
DI 10.1002/ppp.709
PG 9
WC Geography, Physical; Geology
SC Physical Geography; Geology
GA 784BZ
UT WOS:000292129900002
ER

PT J
AU Helgeson, MD
   Lehman, RA
   Cooper, P
   Frisch, M
   Andersen, RC
   Bellabarba, C
AF Helgeson, Melvin D.
   Lehman, Ronald A., Jr.
   Cooper, Patrick
   Frisch, Michael
   Andersen, Romney C.
   Bellabarba, Carlo
TI Retrospective Review of Lumbosacral Dissociations in Blast Injuries
SO SPINE
LA English
DT Review
DE combat-related lumbosacral dissociation injury; high-energy trauma; zone
   III sacral fracture
ID TRAUMATIC SPONDYLOPELVIC DISSOCIATION; SACRAL FRACTURE-DISLOCATIONS;
   BILATERAL FRACTURE; STABILIZATION
AB Study Design. Retrospective review of medical records and radiographs.
   Objective. We assessed the clinical outcomes of lumbosacral dissociation (LSD) after traumatic, combat-related injuries, and to review our management of these distinct injuries and report our preliminary follow-up.
   Summary of Background Data. LSD injuries are an anatomic separation of the pelvis from the spinal column, and are the result of high-energy trauma. A relative increase in these injuries has been seen in young healthy combat casualties subjected to high-energy blast trauma.
   Methods. We performed a retrospective review of inpatient/outpatient medical records and radiographs for all patients treated at our institution with combat-related lumbosacral dissociations. Twenty-three patients met inclusion criteria of combat-related lumbosacral dissociations with one-year follow-up. Patients were treated as follows: no fixation (9), sacroiliac screw fixation (8), posterior spinal fusion (5) and sacral plate (1). All patients with radiographic evidence of a zone III sacral fracture, in addition to associated lumbar fractures indicating loss of the iliolumbar ligamentous complex integrity were included.
   Results. In 15 patients, the sacral fracture were an H or U type zone III fracture, whereas in the remaining nine, the sacral fracture was severely comminuted and unable to classify (six open fractures). There was no difference in visual analog scale (VAS) between treatment modalities. Two open injuries had residual infections. One patient treated with an L4-ilium posterior spinal fusion with instrumentation required instrumentation removal for infection. At a mean follow-up of 1.71 years (range, 1-4.5), 11 patients (48%) still reported residual pain and the mean VAS at latest follow-up was 1.7 (range, 0 7).
   Conclusion. Operative stabilization promoted healing and earlier mobilization, but carries a high-postoperative risk of infection. Nonoperative management should be considered in patients whose comorbidities prevent safe stabilization.
C1 [Helgeson, Melvin D.; Lehman, Ronald A., Jr.; Frisch, Michael; Andersen, Romney C.] Walter Reed Natl Mil Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC USA.
   [Lehman, Ronald A., Jr.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Cooper, Patrick] Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA.
   [Bellabarba, Carlo] Mission Med Associates, Dept Orthopaed, Asheville, NC USA.
   [Bellabarba, Carlo] Univ Washington, Spine Surg Serv, Seattle, WA 98195 USA.
RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, 6900 Georgia Ave,Bldg 2,5th Floor Orthopaed Surg, Washington, DC 20307 USA.
EM armyspine@yahoo.com
NR 15
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U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD APR 1
PY 2011
VL 36
IS 7
BP E469
EP E475
DI 10.1097/BRS.0b013e3182077fd7
PG 7
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 737AH
UT WOS:000288537800003
PM 21358474
ER

PT J
AU Yang, Y
   Berry, AA
   Lee, WC
   Garnett, JA
   Marchant, J
   Levine, JA
   Simpson, PJ
   Fogel, SA
   Varney, KM
   Matthews, SJ
   Nataro, JP
   Inman, KG
AF Yang, Yi
   Berry, Andrea A.
   Lee, Wei-Chao
   Garnett, James A.
   Marchant, Jan
   Levine, Jonathan A.
   Simpson, Peter J.
   Fogel, Sarah A.
   Varney, Kristen M.
   Matthews, Steven J.
   Nataro, James P.
   Inman, Keith G.
TI Complete H-1, C-13 and N-15 NMR assignments for donor-strand
   complemented AafA, the major pilin of aggregative adherence fimbriae
   (AAF/II) from enteroaggregative E. coli
SO BIOMOLECULAR NMR ASSIGNMENTS
LA English
DT Article
DE AafA; Aggregative adherence fimbriae; Adhesin; Donor strand;
   Enteroaggregative; NMR resonance assignment
ID ESCHERICHIA-COLI; PROTEINS; ADHESIN
AB Aggregative adherence fimbriae (AAF) are the primary adhesive factors of enteroaggregative Escherichia coli (EAEC) and are required for intestinal colonization. They mediate binding to extracellular matrix proteins of the enteric mucosa and display proinflammatory effects on epithelial cells in vitro. Among the simplest of bacterial fimbriae, these passive hairlike appendages are composed primarily of a single 16-kDa structural and adhesive subunit, AafA. Oligomerization occurs by incorporating the N-terminal strand of each AafA subunit into an otherwise incomplete beta-sheet of an adjacent AafA subunit. We have engineered a highly soluble AafA monomer by positioning the N-terminal "donor strand" at the C-terminus, following a turn and short linker that were introduced to allow access of the donor strand to the recipient cleft of the same subunit. The resulting "donor-strand complemented" AafA subunit, or AafA-dsc folds autonomously, is monodisperse in solution, and yields high quality NMR spectral data. Here, we report the H-1, C-13, and N-15 chemical shift assignments for AafA-dsc.
C1 [Inman, Keith G.] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA.
   [Yang, Yi; Lee, Wei-Chao; Garnett, James A.; Marchant, Jan; Simpson, Peter J.; Matthews, Steven J.] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, Dept Life Sci, London SW7 2AZ, England.
   [Berry, Andrea A.; Garnett, James A.; Fogel, Sarah A.; Nataro, James P.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Div Infect Dis & Trop Pediat, Baltimore, MD 21201 USA.
   [Varney, Kristen M.] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA.
RP Inman, KG (reprint author), Walter Reed Army Med Ctr, Dept Clin Invest, Bldg 7,Room 203,6900 Georgia Ave NW, Washington, DC 20307 USA.
EM inman.kg@gmail.com
FU University of Maryland School of Medicine Department of Pediatrics
FX KGI acknowledges support from the University of Maryland School of
   Medicine Department of Pediatrics. The current employer of KGI requires
   the following statement: "The views expressed in this article are those
   of the authors and do not reflect the official policy of the Department
   of Army, Department of Defense, or U.S. Government."
NR 13
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U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1874-2718
J9 BIOMOL NMR ASSIGN
JI Biomol. NMR Assign.
PD APR
PY 2011
VL 5
IS 1
BP 1
EP 5
DI 10.1007/s12104-010-9252-7
PG 5
WC Biophysics; Spectroscopy
SC Biophysics; Spectroscopy
GA 730ZO
UT WOS:000288076300001
PM 20814767
ER

PT J
AU Williams, TN
   Newman, JC
   Gullett, PM
AF Williams, T. N.
   Newman, J. C., Jr.
   Gullett, P. M.
TI Crack-surface displacements for cracks emanating from a circular hole
   under various loading conditions
SO FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES
LA English
DT Article
DE circular hole; crack; displacements; stress-intensity factor
ID CLOSURE
AB The purpose of this paper is to calculate and develop equations for crack-surface displacements for two-symmetric cracks emanating from a circular hole in an infinite plate for use in strip-yield crack-closure models. In particular, the displacements were determined under two loading conditions: (1) remote applied stress and (2) uniform stress applied to a segment of the crack surface (partially loaded crack). The displacements were calculated by an integral-equation method based on accurate stress-intensity factor equations for concentrated forces applied to the crack surfaces and those for remote applied stress or for a partially loaded crack surface. A boundary-element code was also used to calculate crack-surface displacements for some selected cases. Comparisons made with crack-surface displacement equations previously developed for the same crack configuration and loading showed significant differences near the location where the crack intersected the hole surface. However, the previous equations were fairly accurate near the crack-tip location. Herein an improved crack-surface displacement equation was developed for the case of remote applied stress. For the partially loaded crack case, only numerical comparisons were made between the previous equations and numerical integration. A rapid algorithm, based on the integral-equation method, was developed to calculate these displacements. Because cracks emanating from a hole are quite common in the aerospace industry, accurate displacement solutions are crucial for improving life-prediction methods based on the strip-yield crack-closure models.
C1 [Newman, J. C., Jr.] Mississippi State Univ, Dept Aerosp Engn, Mississippi State, MS 39762 USA.
   [Williams, T. N.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Gullett, P. M.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
RP Newman, JC (reprint author), Mississippi State Univ, Dept Aerosp Engn, Mississippi State, MS 39762 USA.
EM j.c.newman.jr@ae.msstate.edu
FU Mississippi State University; Department of Energy [DE-FC26-06NT42755]
FX T. N. W. thanks the Center for Advanced Vehicular Systems (CAVS) at
   Mississippi State University for providing the computational resources
   used in this research; J.C.N. thanks Drs. Bal Annigeri and Rick Pettit,
   Pratt-Whitney Corporation, for providing partially financial support for
   his research at Mississippi State University; and the work of P. M. G.
   was performed under contract number DE-FC26-06NT42755 for the Department
   of Energy.
NR 12
TC 7
Z9 9
U1 1
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 8756-758X
J9 FATIGUE FRACT ENG M
JI Fatigue Fract. Eng. Mater. Struct.
PD APR
PY 2011
VL 34
IS 4
BP 250
EP 259
DI 10.1111/j.1460-2695.2010.01512.x
PG 10
WC Engineering, Mechanical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA 731RS
UT WOS:000288127600003
ER

PT J
AU Tsukamoto, T
   Antonic, V
   El Hajj, II
   Stojadinovic, A
   Binion, DG
   Izadjoo, MJ
   Yokota, H
   Pape, HC
   Bauer, AJ
AF Tsukamoto, T.
   Antonic, V.
   El Hajj, I. I.
   Stojadinovic, A.
   Binion, D. G.
   Izadjoo, M. J.
   Yokota, H.
   Pape, H. C.
   Bauer, A. J.
TI Novel model of peripheral tissue trauma-induced inflammation and
   gastrointestinal dysmotility
SO NEUROGASTROENTEROLOGY AND MOTILITY
LA English
DT Article
DE gastrointestinal motility; ileus; inflammation; tissue injury; trauma;
   wound fluid
ID MURINE POSTOPERATIVE ILEUS; MULTIPLE ORGAN FAILURE; NITRIC-OXIDE
   SYNTHASE; LUNG INJURY; HYALURONAN FRAGMENTS; HEMORRHAGIC-SHOCK;
   RESUSCITATION; COMPONENTS; LIVER
AB Background
   Trauma is a leading cause of death and although the gut is recognized as the 'motor' of post-traumatic systemic inflammatory response syndrome and multiple organ failure, studies on the gastrointestinal (GI) tract are few. Our objectives were to create a precisely controllable tissue injury model in which GI motility, systemic inflammation and wound fluid can be analyzed.
   Methods
   A non-narcotic murine trauma model was developed by the subcutaneous dorsal trans-implantation of a devitalized donor syngeneic harvested tissue-bone matrix (TBX), which was precisely adjusted to % total body weight and studied after 21 h. Gastrointestinal transit histograms were plotted after the oral administration of non-digestible FITC-dextran and geometric centers calculated. Organ bath evaluated jejunal circular muscle contractility. Multiplex electrochemiluminescence measurements of serum and TBX wound fluid inflammatory mediators were performed.
   Key Results
   Increasing TBX amounts progressively delayed transit, whereas TBX heat denaturation or decellularization prevented ileus and death. In the TBX(17.5%) model, jejunal muscle contractility was suppressed and a systemic inflammatory response developed as significant serum elevations in IL-6, keratinocyte cytokine and IL-10 compared to sham. In addition, inflammatory responses within the wound fluid showed elevated levels of preformed IL-1 beta and TNF-alpha, whereas, 21 h after implantation IL-1 beta, IL-6 and keratinocyte cytokine were significantly increased in the wound.
   Conclusions & Inferences
   A novel donor tissue-bone matrix trauma model was developed that is precisely adjustable and recapitulates important clinical phenomena. The non-narcotic model demonstrated that increasing tissue injury progressively caused ileus, initiated a systemic inflammatory response and developed inflammatory changes within the wound.
C1 [Tsukamoto, T.; El Hajj, I. I.; Binion, D. G.; Pape, H. C.; Bauer, A. J.] Univ Pittsburgh, Dept Med Gastroenterol, Pittsburgh, PA 15261 USA.
   [Antonic, V.; Stojadinovic, A.] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA.
   [Izadjoo, M. J.] Armed Forces Inst Pathol, Div Wound Biol & Translat Res, Washington, DC 20306 USA.
   [Tsukamoto, T.; Yokota, H.] Nippon Med Sch, Dept Emergency & Crit Care Med, Tokyo 113, Japan.
RP Bauer, AJ (reprint author), Univ Pittsburgh, Dept Med Gastroenterol, S-849 Scaife Hall,3550 Terrace St, Pittsburgh, PA 15261 USA.
EM tbauer@pitt.edu
FU National Institutes of Health [R01-GM58241, R01-DK068610, P50-GM-53789,
   DK02488]; Congressional Combat Wound Initiative Program; Henry M.
   Jackson Foundation for the Advancement of Military Medicine
FX The authors thank Dr. Annette Wilson for her technical assistance in the
   decellularization of the TBX, the National Institutes of Health for the
   following funding: (R01-GM58241, R01-DK068610, P50-GM-53789, and
   DK02488), the Congressional Combat Wound Initiative Program, and the
   Henry M. Jackson Foundation for the Advancement of Military Medicine.
   Both civilian and military personnel involved in this study are
   dedicated to improving the lives of those who have been placed in harm's
   way for the good of our nation.
NR 25
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U1 0
U2 0
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1350-1925
J9 NEUROGASTROENT MOTIL
JI Neurogastroenterol. Motil.
PD APR
PY 2011
VL 23
IS 4
DI 10.1111/j.1365-2982.2011.01675.x
PG 9
WC Gastroenterology & Hepatology; Clinical Neurology; Neurosciences
SC Gastroenterology & Hepatology; Neurosciences & Neurology
GA 733KR
UT WOS:000288262100014
ER

PT J
AU Spevak, C
   Buckenmaier, C
AF Spevak, Christopher
   Buckenmaier, Chester, III
TI Catastrophizing and Pain in Military Personnel
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
DE Pain; Catastrophizing; Trauma; Injuries; Posttraumatic stress disorder;
   Cognitive therapy; Behavioral therapy; Hypervigilance; Mental defeat;
   Coping
ID OPERATION IRAQI FREEDOM; BRIGADE COMBAT TEAM; QUALITY-OF-LIFE;
   POSTOPERATIVE PAIN; POSTSURGICAL PAIN; SOLDIERS; INJURY; HEALTH;
   EPIDEMIOLOGY; MECHANISMS
AB Combat-related injuries have been well documented for centuries. More recently, injuries suffered by US service members in Iraq and Afghanistan have resulted in a high number of survivable conditions. Polytrauma care in this setting must take into account both the physical and psychological injuries suffered by returning wounded warriors. Catastrophizing may occur when previously healthy individuals are faced with impairment and disfigurement. This is compounded with repeated operative procedures. Early detection and treatment of catastrophizing contributes to improved care of the wounded warrior. This article describes our experiences at Walter Reed Army Medical Center with catastrophizing in US service members returning from the current military operations in Iraq and Afghanistan.
C1 [Spevak, Christopher] Georgetown Univ Hosp, Washington, DC 20007 USA.
   [Buckenmaier, Chester, III] Walter Reed Army Med Ctr, Acute Pain Med Serv, Washington, DC 20307 USA.
RP Spevak, C (reprint author), Georgetown Univ Hosp, Washington, DC 20007 USA.
EM cs25@Georgetown.edu; Chester.Buckenmaier@us.army.mil
OI Buckenmaier III, Chester/0000-0003-3623-5525
NR 33
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U1 0
U2 5
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1531-3433
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD APR
PY 2011
VL 15
IS 2
BP 124
EP 128
DI 10.1007/s11916-011-0173-7
PG 5
WC Clinical Neurology
SC Neurosciences & Neurology
GA 729CT
UT WOS:000287926600009
PM 21267678
ER

PT J
AU Compton, JR
   Legler, PM
   Clingan, BV
   Olson, MA
   Millard, CB
AF Compton, Jaimee R.
   Legler, Patricia M.
   Clingan, Benjamin V.
   Olson, Mark A.
   Millard, Charles B.
TI Introduction of a disulfide bond leads to stabilization and
   crystallization of a ricin immunogen
SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
LA English
DT Article
DE aggregation; unfolding; subunit vaccine; toxin; protein engineering;
   crystal packing
ID RIBOSOME-INACTIVATING PROTEIN; A-CHAIN; HODGKINS LYMPHOMA;
   GLOBULAR-PROTEINS; CELL EPITOPE; T4 LYSOZYME; STABILITY; VACCINE;
   SUBTILISIN; DISPLAY
AB RTA1-33/44-198 is a catalytically inactive, single-domain derivative of the ricin toxin A-chain (RTA) engineered to serve as a stable protein scaffold for presentation of native immunogenic epitopes (Olson et al., Protein Eng Des Sel 2004; 17: 391-397). To improve the stability and solubility of RTA1-33/44-198 further, we have undertaken the design challenge of introducing a disulfide (SS) bond. Nine pairs of residues were selected for placement of the SS-bond based on molecular dynamics simulation studies of the modeled single-domain chain. Disulfide formation at either of two positions (R48C/T77C or V49C/E99C) involving a specific surface loop (44-55) increased the protein melting temperature by similar to 5 degrees C compared with RTA1-33/44-198 and by similar to 13 degrees C compared with RTA. Prolonged stability studies of the R48C/T77C variant (> 60 days at 37 degrees C, pH 7.4) confirmed a > 40% reduction in self-aggregation compared with RTA1-33/44-198 lacking the SS-bond. The R48C/T77C variant retained affinity for anti-RTA antibodies capable of neutralizing ricin toxin, including a monoclonal that recognizes a human B-cell epitope. Introduction of either R48C/T77C or V49C/E99C promoted crystallization of RTA1-33/44-198, and the X-ray structures of the variants were solved to 2.3 angstrom or 2.1 angstrom resolution, respectively. The structures confirm formation of an intramolecular SS-bond, and reveal a single-domain fold that is significantly reduced in volume compared with RTA. Loop 44 to 55 is partly disordered as predicted by simulations, and is positioned to form self-self interactions between symmetry-related molecules. We discuss the importance of RTA loop 34 to 55 as a nucleus for unfolding and aggregation, and draw conclusions for ongoing structure-based minimalist design of RTA-based immunogens.
C1 [Millard, Charles B.] USA, Med Res & Mat Command, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
   [Compton, Jaimee R.; Legler, Patricia M.; Clingan, Benjamin V.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Millard, CB (reprint author), USA, Med Res & Mat Command, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM charles.b.millard@us.army.mil
FU U.S. Defense Threat Reduction Agency [S.S.0003_06_WR_B]; National
   Institutes of Health [U01 A1082120-01]
FX Grant sponsor: U.S. Defense Threat Reduction Agency JSTO award (to
   C.B.M.); Grant number: S.S.0003_06_WR_B; Grant sponsor: National
   Institutes of Health (to C.B.M.); Grant number: U01 A1082120-01.
NR 58
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U1 2
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-3585
EI 1097-0134
J9 PROTEINS
JI Proteins
PD APR
PY 2011
VL 79
IS 4
BP 1048
EP 1060
DI 10.1002/prot.22933
PG 13
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 731VY
UT WOS:000288138700003
PM 21387408
ER

PT J
AU Marsh, CP
   Stynoski, PB
   Carlson, TA
   Arnett, C
   Newcomb, B
   Strano, MS
   Welch, CR
AF Marsh, Charles P.
   Stynoski, Peter B.
   Carlson, Thomas A.
   Arnett, Clint
   Newcomb, Brad
   Strano, Michael S.
   Welch, Charles R.
TI Experimental demonstration of meso-scale carbon nanotube self-assembled
   tube structures
SO CARBON
LA English
DT Article
ID GROWTH; DECOMPOSITION; FIBERS; ARRAYS; FLOW
AB In addition to numerous other properties of interest, carbon nanotubes (CNT) promise to form a basis for new materials of extraordinary strength owing mainly to the very high carbon-carbon bond energies and their unique tubular structure at the molecular scale. In the area of materials development, the guiding concept of bio-inspired hierarchical structures combined with controlled fabrication at multiple scales has the potential to result in substantially improved mechanical performance. Here we show examples of a multiple-scale self-assembled tube structure, which are themselves composed of multi-wall CNTs, while also demonstrating some important aspects of their nucleation and growth. These hierarchical and self-assembled objects strongly indicate the feasibility of controlled synthesis of macroscopic CNT structures and CNT-reinforced materials for use in various engineering applications. These applications could encompass the areas of structures, thermal transfer, electronics, fluid dynamics, and micro-fluidics. Published by Elsevier Ltd.
C1 [Marsh, Charles P.; Stynoski, Peter B.; Carlson, Thomas A.; Arnett, Clint; Newcomb, Brad; Welch, Charles R.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Marsh, Charles P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA.
   [Strano, Michael S.] MIT, Dept Chem Engn 66 566, Cambridge, MA 02139 USA.
RP Marsh, CP (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Charles.P.Marsh@usace.army.mil
RI Zhou, Charlie/N-5376-2015
FU US Army Corps of Engineers Research, Development, Testing, and
   Evaluation; US Department of Energy; ERDC-CERL
FX This research was funded by the US Army Corps of Engineers Research,
   Development, Testing, and Evaluation 6.2 funding. This research was
   carried out in part at the Frederick Seitz Materials Research Laboratory
   Central Facilities, University of Illinois at Urbana-Champaign, which is
   partially supported by the US Department of Energy. This research was
   also supported in part by an appointment to the Postgraduate Research
   Participation Program at the U.S. Army Engineer Research and Development
   Center, Construction Engineering Research Laboratory, administered by
   the Oak Ridge Institute for Science and Education through an interagency
   agreement between the US Department of Energy and ERDC-CERL. The authors
   would like to acknowledge Ryan J. Franks for his contributions during
   the early stages of this research, reviewing relevant literature and
   selecting experimental components.
NR 28
TC 2
Z9 2
U1 2
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-6223
J9 CARBON
JI Carbon
PD APR
PY 2011
VL 49
IS 4
BP 1235
EP 1242
DI 10.1016/j.carbon.2010.11.040
PG 8
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA 717NR
UT WOS:000287055200023
ER

PT J
AU DuBois, TG
   Nieh, S
AF DuBois, Terry G.
   Nieh, Sen
TI Selection and performance comparison of jet fuel surrogates for
   autothermal reforming
SO FUEL
LA English
DT Article
DE Surrogate fuel; Partial oxidation; Autothermal reforming; Jet fuel; Fuel
   cell
ID CATALYTIC PARTIAL OXIDATION; REFERENCE COMPONENTS; HIGHER HYDROCARBONS;
   JP-8; MIXTURES; SYNGAS; SULFUR; SCALE
AB Three fuel mixtures were investigated as possible surrogates for low-sulfur JP-8. The selected fuel mixtures were chosen based on a desire to match hydrocarbon chemical composition classes found in real jet fuels. The surrogate fuels selected consisted of single, binary and tertiary-component mixtures of n-dodecane, decalin and toluene in liquid volume ratios of 10: 0: 0, 9: 1: 0 and 7:1:2. The hydrocarbon components selected represented the largest chemical classes within JP-8 of normal paraffin, cyclo-paraffin and aromatic. The surrogate fuels and individual surrogate fuel components were reacted in an atmospheric pressure autothermal reformer with noble metal catalysts under conditions of steam-to-carbon ratio of 2.0, fuel equivalency energy flow of 3.3 kW thermal, space velocities of 21,000-28,000 h(-1) and variable oxygen-to-carbon ratios of 0.8-1.2. For all fuels investigated fuel conversion of greater than 96% could be achieved. The single component n-dodecane proved to be the least reactive resulting in lower hydrogen yields, lower reforming efficiency and increased olefin products in the reformate. The binary mixture of n-dodecane and decalin resulted in a closer match with JP-8, but did not correlate well in terms of fuel conversion and hydrogen yield. Aliphatic mixtures also exhibited greater olefin production. The three-component mixture of n-dodecane/decalin/toluene provided the best correlation to JP-8 and appears to be a good three-component surrogate fuel, particularly over the operating range of oxygen to carbon ratio of 0.95-1.10. Published by Elsevier Ltd.
C1 [DuBois, Terry G.] USA, Res Dev & Engn Command, Ft Belvoir, VA 22060 USA.
   [Nieh, Sen] Catholic Univ Amer, Dept Mech Engn, Washington, DC 20064 USA.
RP DuBois, TG (reprint author), USA, Res Dev & Engn Command, 10125 Gratiot Rd, Ft Belvoir, VA 22060 USA.
EM terry.dubois@us.army.mil
FU US Army Communications-Electronics RDE Center
FX The authors gratefully acknowledge the US Army
   Communications-Electronics RDE Center's support in the form of an
   In-House Independent Laboratory Research (ILIR) program that funded this
   research.
NR 41
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Z9 17
U1 1
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0016-2361
EI 1873-7153
J9 FUEL
JI Fuel
PD APR
PY 2011
VL 90
IS 4
BP 1439
EP 1448
DI 10.1016/j.fuel.2010.12.040
PG 10
WC Energy & Fuels; Engineering, Chemical
SC Energy & Fuels; Engineering
GA 725NN
UT WOS:000287652300015
ER

PT J
AU Hakre, S
   Brett-Major, D
   Singer, DE
   O'Connell, RJ
   Sateren, WB
   Sanchez, JL
   Agan, BK
   Michael, NL
   Scott, PT
AF Hakre, Shilpa
   Brett-Major, David
   Singer, Darrell E.
   O'Connell, Robert J.
   Sateren, Warren B.
   Sanchez, Jose L.
   Agan, Brian K.
   Michael, Nelson L.
   Scott, Paul T.
TI Medical Encounter Characteristics of HIV Seroconverters in the US Army
   and Air Force, 2000-2004
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
ID DEPARTMENT-OF-DEFENSE; UNITED-STATES-ARMY; MISSED OPPORTUNITIES;
   PREVENTION PROGRAMS; VIRAL LOAD; INFECTION; DIAGNOSIS; ADULTS; MILITARY;
   CARE
AB Background and Methods: Active duty US Army and Air Force military personnel undergo mandatory biennial HIV antibody screening. We compared pre- and post-HIV seroconversion health status by conducting a case-control study, which evaluated all medical encounters and sociodemographic factors among incident HIV seroconverters and HIV-negative controls from June 2000 through February 2004.
   Results: A total of 274 HIV seroconverters and 6205 HIV-negative personnel were included. In multivariate analysis restricted to male personnel (cases = 261, controls = 5801), single marital status (adjusted odds ratio [AOR] = 14.37), clinical indicators or symptoms within four years of HIV diagnosis (AOR = 6.22), black race (AOR = 5.88), nonindicator clinical syndromes within 2 years of HIV diagnosis (AOR = 3.31), any mental disorder within 4 years of HIV diagnosis (AOR = 3.04), increasing service-connected time (AOR = 1.69), and older age (AOR = 1.12) were associated with HIV diagnosis among males. A prior history of a sexually transmitted infection (STI) was associated with post-HIV seroconversion STI (OR(M-H) = 4.10). Similarly, a prior history of mental disorder was associated with post-HIV seroconversion mental disorder (OR(M-H) = 4.98). Forty-seven (18%) male cases were hospitalized at least once after HIV diagnosis; infectious diseases, and mental disorders made up 53% of initial admissions.
   Conclusions: HIV seroconversion was associated with increased health care-seeking behavior, STIs, and mental disorders, some of which may be amenable to screening. The higher STI rate after HIV diagnosis may partially be a consequence of monitoring, but secondary transmission of STI and possibly HIV require further definition and subsequent tailored preventive interventions.
C1 [Hakre, Shilpa] US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA.
   [Brett-Major, David] USN, US Mil Trop Med, Med Manpower Personnel Training & Educ Command, Bethesda, MD USA.
   [Brett-Major, David] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
   [Singer, Darrell E.; O'Connell, Robert J.; Sateren, Warren B.; Michael, Nelson L.; Scott, Paul T.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA.
   [Sanchez, Jose L.] Armed Forces Hlth Surveillance Ctr, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD USA.
   [Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
RP Hakre, S (reprint author), US Mil HIV Res Program, Dept Epidemiol & Threat Assessment, Henry M Jackson Fdn Adv Mil Med, 1 Taft Ct Suite 250, Rockville, MD 20850 USA.
EM shakre@hivresearch.org
OI Agan, Brian/0000-0002-5114-1669
FU Military Infectious Disease Research Program [1A0001_06_WR_OC]
FX This work was supported by funds from the Military Infectious Disease
   Research Program (Proposal 1A0001_06_WR_OC) and approved by the Walter
   Reed Army Institute of Research Institutional Review Board (#1109).
NR 43
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Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1525-4135
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR
PY 2011
VL 56
IS 4
BP 372
EP 385
DI 10.1097/QAI.0b013e31820a7f4d
PG 14
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 726QH
UT WOS:000287740700021
PM 21266911
ER

PT J
AU Pankow, M
   Justusson, B
   Salvi, A
   Waas, AM
   Yen, CF
   Ghiorse, S
AF Pankow, M.
   Justusson, B.
   Salvi, A.
   Waas, A. M.
   Yen, Chian-Fong
   Ghiorse, Seth
TI Shock response of 3D woven composites: An experimental investigation
SO COMPOSITE STRUCTURES
LA English
DT Article
DE Shock loading; Matrix micro-cracking; High strain rate; 3D woven;
   Bending; Material characterization
ID WAVE-LOADED PLATES; DAMAGE
AB A modified shock tube was used to determine the effect of shock wave loading on 3D woven composite panels. The shock wave, which produces a short duration steeply rising pressure pulse when impacting the panel, was used to load the panels. The out of plane deformation response was measured using a full field Digital Image Correlation (DIC) technique. The results allow for measurements of full field displacements and strains in the samples. Three distinct textile composite architectures, corresponding to different amounts of Z-fiber (fiber tows that bind the different textile layers together) were investigated. Two separate shock intensities were used. Matrix micro-cracking was observed to be the mechanism by which failure is initiated, and this micro-cracking was found to occur closest to the center of the panel where the outer-surface straining is highest. Fiber tow failure was absent in the shock strengths studied in the present work. The results suggest that the 6% Z-fiber architecture provided the largest panel stiffness and the least amount of damage. This result suggests that this may be the optimal architecture and density for orthogonally woven 2-fiber reinforced composites, however due to the complex nature of the problem the same architecture with a different tow (and fiber) volume fraction may yield different results. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Pankow, M.; Justusson, B.; Salvi, A.; Waas, A. M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA.
   [Yen, Chian-Fong; Ghiorse, Seth] USA, Res Lab, Aberdeen Proving Ground, MD USA.
RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA.
EM dcw@umich.edu
FU US Army Research Laboratories, Aberdeen proving grounds, MD
FX The authors would like to thank the US Army Research Laboratories,
   Aberdeen proving grounds, MD, for their continued financial support.
NR 17
TC 8
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U1 1
U2 23
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-8223
J9 COMPOS STRUCT
JI Compos. Struct.
PD APR
PY 2011
VL 93
IS 5
BP 1337
EP 1346
DI 10.1016/j.compstruct.2010.10.021
PG 10
WC Materials Science, Composites
SC Materials Science
GA 718HC
UT WOS:000287110700003
ER

PT J
AU Pankow, M
   Waas, AM
   Yen, CF
   Ghiorse, S
AF Pankow, M.
   Waas, A. M.
   Yen, Chian-Fong
   Ghiorse, Seth
TI Shock loading of 3D woven composites: A validated finite element
   investigation
SO COMPOSITE STRUCTURES
LA English
DT Article
DE Shock loading; Matrix micro-cracking; High strain rate; Shock modeling;
   Material characterization; Finite elements
ID WAVE-LOADED PLATES; FAILURE; IMPACT; DAMAGE; BEHAVIOR
AB In a companion paper in this issue (Pankow et al., 2010 [1]), experimental results for the deformation response of 3D glass fiber textile composites subjected to shock wave pulse pressure loading were presented. In this paper, finite element models are developed to simulate the deformation response and damage development observed in the experiments. Two levels of models are presented, with the first focused on a layered, homogenous orthotropic model that examined the bulk macroscopic deformation response. In the second model, each layer is represented to capture the interactions between fiber tows and matrix, taking into account the discrete non-homogeneous material distribution in each layer. Both models incorporated a user defined subroutine within the commercial software ABAQUS to capture matrix micro-cracking, which is responsible for damage development and growth. Results from the computational models correlated well with experimental results and observed locations of matrix microcracking. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Pankow, M.; Waas, A. M.] Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, Ann Arbor, MI 48109 USA.
   [Yen, Chian-Fong; Ghiorse, Seth] USA, Res Lab, Aberdeen Proving Ground, MD USA.
RP Waas, AM (reprint author), Univ Michigan, Dept Aerosp Engn, Composite Struct Lab, 1320 Beal St, Ann Arbor, MI 48109 USA.
EM dcw@umich.edu
FU Army Research Laboratory
FX The authors would like to thank the Army Research Laboratory for their
   continued financial support.
NR 27
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U1 2
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-8223
J9 COMPOS STRUCT
JI Compos. Struct.
PD APR
PY 2011
VL 93
IS 5
BP 1347
EP 1362
DI 10.1016/j.compstruct.2010.11.001
PG 16
WC Materials Science, Composites
SC Materials Science
GA 718HC
UT WOS:000287110700004
ER

PT J
AU Kott, A
   Singh, R
   McEneaney, WM
   Milks, W
AF Kott, Alexander
   Singh, Rajdeep
   McEneaney, William M.
   Milks, Wes
TI Hypothesis-driven information fusion in adversarial, deceptive
   environments
SO INFORMATION FUSION
LA English
DT Article
DE Information fusion; Military intelligence; Risk-sensitive control;
   Adversarial reasoning; Deception analysis
ID RISK-SENSITIVE CONTROL; INFINITE TIME HORIZON; PORTFOLIO OPTIMIZATION;
   DIFFERENTIAL-GAMES; STATE; MODEL
AB The problem domain addressed in this work is urban, armed engagement against a guerilla force. The paper focuses particularly on the algorithm developed to combine incomplete and potentially deceptive observations of the opponent forces and actions into a fused estimate of the opponent's actual positions and strengths. The algorithm generates and maintains a set of hypotheses, and evaluates each hypothesis in a manner that combines ongoing observations with recognition of the opponent's efforts to conceal its forces and to deceive. The theoretical foundations of the proposed approach derive primarily from the theory of risk-sensitive control. The paper describes an implementation of the proposed approach that approximates theoretical constructs with heuristics for the sake of computational feasibility in applications that require near-real-time generation of fused estimates. Multiple realistic experiments, including live force experiments, demonstrated quantitatively that the resulting tools are capable of producing estimates at least comparable in accuracy to those produced by competent humans. The paper also discusses the potential incorporation of the tools into operational battle command systems. Published by Elsevier B.V.
C1 [Singh, Rajdeep] IS&GS Lockheed Martin, San Diego, CA 92121 USA.
   [Kott, Alexander] USA, Res Lab, Adelphi, MD 20783 USA.
   [McEneaney, William M.] Univ Calif San Diego, La Jolla, CA 92093 USA.
   [Milks, Wes] Lockheed Martin, Orlando, FL 32825 USA.
RP Singh, R (reprint author), IS&GS Lockheed Martin, San Diego, CA 92121 USA.
EM alexander.kott1@us.army.mil; rajdeep.singh@lmco.com;
   wmceneaney@ucsd.edu; wesley.milks@lmco.com
FU United States Defense Advanced Research Programs Agency (DARPA)
FX The authors thank the United States Defense Advanced Research Programs
   Agency (DARPA) for providing support to this research and for granting
   the permission to publish certain results (approved for public release,
   distribution unlimited). We are also grateful to numerous colleagues who
   contributed to the development of the RAID tool and to the experiments.
NR 57
TC 5
Z9 5
U1 1
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-2535
J9 INFORM FUSION
JI Inf. Fusion
PD APR
PY 2011
VL 12
IS 2
BP 131
EP 144
DI 10.1016/j.inffus.2010.09.001
PG 14
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
   Methods
SC Computer Science
GA 720MU
UT WOS:000287285600007
ER

PT J
AU Torrieri, D
AF Torrieri, D.
TI Simple formulas for SIMO and MISO ergodic capacities
SO ELECTRONICS LETTERS
LA English
DT Article
AB Simple formulas for the SIMO and MISO ergodic capacities of independent Rayleigh fading channels with uniform power distribution are derived. These formulas are closed-form solutions of integrals if the special functions are included among the well-known functions.
C1 USA, Res Lab, Adelphi, MD 20783 USA.
RP Torrieri, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
NR 1
TC 2
Z9 2
U1 0
U2 2
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 0013-5194
J9 ELECTRON LETT
JI Electron. Lett.
PD MAR 31
PY 2011
VL 47
IS 7
BP 468
EP 468
DI 10.1049/el.2010.3597
PG 1
WC Engineering, Electrical & Electronic
SC Engineering
GA 741VH
UT WOS:000288893100034
ER

PT J
AU Vatamanu, J
   Borodin, O
   Smith, GD
AF Vatamanu, Jenel
   Borodin, Oleg
   Smith, Grant D.
TI Molecular Simulations of the Electric Double Layer Structure,
   Differential Capacitance, and Charging Kinetics for
   N-Methyl-N-propylpyrrolidinium Bis(fluorosulfonyl)imide at Graphite
   Electrodes
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID TEMPERATURE IONIC LIQUIDS; 2-DIMENSIONAL PERIODICITY; 3-DIMENSIONAL
   SYSTEMS; RAPID CALCULATION; DYNAMICS SIMULATIONS; COMPUTER-SIMULATION;
   NANOPOROUS CARBON; COULOMB COMPONENT; SURFACE-CHARGE; STRESS TENSOR
AB Molecular dynamics simulations were performed on N-methyl-N-propylpyrrolidinium bis(fluorosulfonyl)imide (pyr(13)FSI) room temperature ionic liquid (RTIL) confined between graphite electrodes as a function of applied potential at 393 and 453 K using an accurate force field developed in this work. The electric double layer (EDL) structure and differential capacitance (DC) of pyr(13)FSI was compared with the results of the previous study of a similar RTIL pyr(13)bis(trifluoromethanesulfonyl)imide (pyr(13)TFSI) with a significantly larger anion [Vatamanu, J.; Borodin, O.; Smith, G. D. J. Am. Chem. Soc. 2010, 132, 14825]. Intriguingly, the smaller size of the FSI anion compared to TFSI did not result in a significant increase of the DC on the positive electrode. Instead, a 30% higher DC was observed on the negative electrode for pyr(13)FSI compared to pyr(13)TFSI. The larger DC observed on the negative electrode for pyr(13)FSI compared to pyr(13)TFSI was associated with two structural features of the EDL: (a) a closer approach of FSI compared to TFSI to the electrode surface and (b) a faster rate (vs potential decrease) of anion desorption from the electrode surface for FSI compared to TFSI. Additionally, the limiting behavior of DC at large applied potentials was investigated. Finally, we show that constant potential simulations indicate time scales of hundreds of picoseconds required for electrode charge/discharge and EDL formation.
C1 [Vatamanu, Jenel; Borodin, Oleg; Smith, Grant D.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
   [Borodin, Oleg] Wasatch Mol Inc, Salt Lake City, UT 84108 USA.
   [Borodin, Oleg] USA, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
RP Vatamanu, J (reprint author), Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
RI Borodin, Oleg/B-6855-2012; Vatamanu, Jenel/I-7638-2012
OI Borodin, Oleg/0000-0002-9428-5291; Vatamanu, Jenel/0000-0003-0825-1608
FU Department of Energy [DE-SC0001912]; Air Force Office of Scientific
   Research, Department of the Air Force [FA9550-09-C-0110]; Office of
   Science of the U.S. Department of Energy [DE-AC02-05CH11231]
FX The authors are grateful to the Department of Energy for contract grant
   DE-SC0001912 to the University of Utah. The united atom force field
   development was supported by the Air Force Office of Scientific
   Research, Department of the Air Force contract no. FA9550-09-C-0110 to
   Wasatch Molecular Inc. and University of Utah. This research used
   resources of the National Energy Research Scientific Computing Center,
   which is supported by the Office of Science of the U.S. Department of
   Energy under Contract No. DE-AC02-05CH11231.
NR 76
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U1 6
U2 72
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD MAR 31
PY 2011
VL 115
IS 12
BP 3073
EP 3084
DI 10.1021/jp2001207
PG 12
WC Chemistry, Physical
SC Chemistry
GA 738MU
UT WOS:000288644700045
PM 21384838
ER

PT J
AU Okusaga, O
   Adles, EJ
   Levy, EC
   Zhou, W
   Carter, GM
   Menyuk, CR
   Horowitz, M
AF Okusaga, O.
   Adles, E. J.
   Levy, E. C.
   Zhou, W.
   Carter, G. M.
   Menyuk, C. R.
   Horowitz, M.
TI Spurious mode reduction in dual injection-locked optoelectronic
   oscillators
SO OPTICS EXPRESS
LA English
DT Article
ID PHASE-NOISE
AB Optoelectronic oscillators (OEOs) are promising sources of low phase noise radio frequency (RF) signals. However, at X-band frequencies, the long optical fiber delay line required for a high oscillator Q also leads to spurious modes (spurs) spaced too narrowly to be filtered by RF filters. The dual injection-locked OEO (DIL-OEO) has been proposed as a solution to this problem. In this work, we describe in detail the construction of a DIL-OEO. We also present experimental data from our systematic study of injection-locking in DIL-OEOs. With this data, we optimize the DIL-OEO, achieving both low phase noise and low spurs. Finally, we present data demonstrating a 60 dB suppression of the nearest-neighbor spur without increasing the phase noise within 1 kHz of the 10 GHz central oscillating mode. c 2011 Optical Society of America
C1 [Okusaga, O.; Adles, E. J.; Zhou, W.] USA, Res Lab, Adelphi, MD 20783 USA.
   [Okusaga, O.; Carter, G. M.; Menyuk, C. R.] Univ Maryland Baltimore Cty, Baltimore, MD 21228 USA.
   [Levy, E. C.; Horowitz, M.] Technion Israel Inst Technol, Haifa, Israel.
RP Okusaga, O (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM olukayode.okusaga@us.army.mil
NR 14
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U1 1
U2 6
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAR 28
PY 2011
VL 19
IS 7
BP 5839
EP 5854
DI 10.1364/OE.19.005839
PG 16
WC Optics
SC Optics
GA 741GR
UT WOS:000288852700014
PM 21451609
ER

PT J
AU Karl, JP
   Young, AJ
   Montain, SJ
AF Karl, J. Philip
   Young, Andrew J.
   Montain, Scott J.
TI Eating rate during a fixed-portion meal does not affect postprandial
   appetite and gut peptides or energy intake during a subsequent meal
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Eating rate; Satiety; Cholecystokinin; Glucagon-like peptide-1;
   Pancreatic polypeptide; Peptide-YY
ID FOOD-INTAKE; MENSTRUAL-CYCLE; HEALTHY HUMANS; NORMAL-WEIGHT; BITE SIZE;
   WOMEN; CARBOHYDRATE; SATIETY; LEPTIN; HORMONES
AB Eating rate has recently been shown to influence energy intake and appetite during an ad libitum meal, and alter postprandial secretion of glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) following a fixed-portion meal. Whether these effects influence satiety, as measured by energy intake at the subsequent meal, is unclear. We manipulated eating rate during a fixed-portion meal in order to examine how eating behavior and associated periprandial and postprandial responses of putative endocrine mediators of appetite would affect energy intake at the following meal in fifteen non-obese (BMI < 25 kg/m(2)) and ten obese (BMI >= 30 kg/m(2)) healthy adult men and women. In random order, each participant consumed a standardized, fixed-portion meal in 7 (FM), 14 (MM) or 28 (SM) minutes. Fullness, measured by the Satiety Labeled Intensity Magnitude (SLIM) scale, serum insulin, glucose, leptin, pancreatic polypeptide (PP), PYY, GLP-1, neuropeptide-Y, and plasma cholecystokinin (CCK) were measured for 3 h following the fixed-portion meal. Ad libitum energy intake at the next meal was then measured. Eating slowly delayed time to peak fullness (P <= 0.05), but did not alter peak fullness. Peak PP concentrations were attenuated during FM compared to MM and SM (P <= 0.05) and were reached earlier during MM compared to SM (P <= 0.05). A meal-by-time interaction (P <= 0.05), but no differences in AUC, peak, or time to peak were observed for CCK. No additional between meal differences in AUC, peak or time to peak for any endocrine mediator of appetite was observed.Ad libitum energy intake was not different between trials. In conclusion, the rate at which a fixed-portion meal is consumed does not appear to alter satiety despite a small effect on PP and CCK responses. Published by Elsevier Inc.
C1 [Karl, J. Philip; Young, Andrew J.; Montain, Scott J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
RP Karl, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
EM james.p.karl@us.army.mil
OI Karl, J. Philip/0000-0002-5871-2241
FU US Army Medical Research and Materiel Command
FX The authors wish to acknowledge the volunteers who participated in this
   research. Michael Stanger, SSG Jay O'Hara, SGT Ryan Regalia and SSG
   Bryan Wiley all made significant technical contributions to the
   experiments detailed in this manuscript. Finally, the authors wish to
   acknowledge Dr. Jennifer Rood and her team at the Pennington Biomedical
   Research Center for performance of the assays. Research funded by US
   Army Medical Research and Materiel Command.
NR 39
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U1 3
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAR 28
PY 2011
VL 102
IS 5
BP 524
EP 531
DI 10.1016/j.physbeh.2011.01.007
PG 8
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA 737QC
UT WOS:000288582300014
PM 21238470
ER

PT J
AU Adams, BL
   Bentley, WE
   Valdes, JJ
AF Adams, Bryn L.
   Bentley, William E.
   Valdes, James J.
TI Modulating bacterial signal processing through the directed evolution of
   the AI-2 global regulator protein, LsrR
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Biol Res Ctr, Inst Biosci & Biotechnol Res, College Pk, MD USA.
   Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
   USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 322-BIOT
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982802007
ER

PT J
AU Anton, CM
   Sumner, JJ
   Finch, AS
AF Anton, Christopher M.
   Sumner, James J.
   Finch, Amethist S.
TI DNA architechtures for templated material growth
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 [Anton, Christopher M.; Sumner, James J.; Finch, Amethist S.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD USA.
RI Finch, Amethist/H-9510-2013
OI Finch, Amethist/0000-0002-4650-6301
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 510-COLL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982803710
ER

PT J
AU Bristol, SK
   Hark, RR
   Harmon, RS
   Remus, JJ
AF Bristol, Samantha K.
   Hark, Richard R.
   Harmon, Russell S.
   Remus, Jeremiah J.
TI Analysis of historical volcanic rocks using laser-induced breakdown
   spectroscopy (LIBS)
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA.
   ARL Army Res Off, Durham, NC USA.
   Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY USA.
NR 0
TC 0
Z9 0
U1 2
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 249-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982801314
ER

PT J
AU Chaudhury, S
   Olson, MA
   Tawa, G
   Wallqvist, A
   Lee, MS
AF Chaudhury, Sidhartha
   Olson, Mark A.
   Tawa, Gregory
   Wallqvist, Anders
   Lee, Michael S.
TI Efficient conformational sampling in explicit solvent using a hybrid
   replica exchange molecular dynamics method
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 USA, Biotechnol High Performance Comp Software Applica, Med Res & Mat Command, Frederick, MD USA.
   USA, Dept Cell Biol & Biochem, Med Res Inst Infect Dis, Frederick, MD USA.
   USA, Computat Sci & Engn Branch, Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 268-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982804045
ER

PT J
AU Friedlander, JA
   Gutteridge, CE
   O'Neil, MT
AF Friedlander, J. Alan
   Gutteridge, Clare E.
   O'Neil, Michael T.
TI Development of a novel chemical series with activity against the malaria
   parasite Plasmodium falciparum
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 USN Acad, Dept Chem, Annapolis, MD 21402 USA.
   Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 753-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982800721
ER

PT J
AU Izvekov, S
   Chung, PW
   Rice, BM
AF Izvekov, Sergey
   Chung, Peter W.
   Rice, Betsy M.
TI Coarse-grain modeling of energetic materials
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 [Izvekov, Sergey; Chung, Peter W.; Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD USA.
NR 3
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 16-COMP
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982803993
ER

PT J
AU Jenkins, AL
   Ellzy, MW
   Buettner, LC
AF Jenkins, Amanda L.
   Ellzy, Michael W.
   Buettner, Leonard C.
TI Molecularly imprinted polymer sensors for detection in the gas, liquid
   and vapor phase
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Ask Inc, Hebron, MD USA.
   US Army, ECBC, Gunpowder, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 19-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982807287
ER

PT J
AU Koo, D
   Wiley, A
   Sadler, JM
   La Scala, JJ
   Palmese, GR
AF Koo, Donghun
   Wiley, Alyssa
   Sadler, Joshua M.
   La Scala, John J.
   Palmese, Giuseppe R.
TI Synthesis and characterization of thermosetting isosorbide-based resins
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Drexel Univ, Philadelphia, PA 19104 USA.
   USA, Res Labs, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 22-CELL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982802501
ER

PT J
AU Lambeth, RH
   Rinderspacher, BC
   Andzelm, JW
   Rawlett, AM
AF Lambeth, Robert H.
   Rinderspacher, B. Christopher
   Andzelm, Jan W.
   Rawlett, Adam M.
TI Supramolecular materials from side chain bisbenzimidazoyl pyridine
   acrylic copolymers
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 [Lambeth, Robert H.; Rinderspacher, B. Christopher; Andzelm, Jan W.; Rawlett, Adam M.] USA, Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 8-PMSE
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982806898
ER

PT J
AU Mao, JD
   Cao, XY
   Chappell, MA
   Schimmelmann, A
   Mastalerz, M
   Li, Y
AF Mao, Jingdong
   Cao, Xiaoyan
   Chappell, Mark A.
   Schimmelmann, Arndt
   Mastalerz, Maria
   Li, Yuan
TI Chemical structural changes in kerogen from bituminous coal in response
   to dike intrusions as investigated by advanced C-13 solid-state NMR
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 39180 USA.
   USA, Corps Engineers, Environm Lab, Vicksburg, MS 47405 USA.
   Indiana Univ, Dept Geol Sci, Bloomington, IN USA.
   Indiana Geol Survey, Bloomington, IN USA.
RI Cao, Xiaoyan/E-3492-2012
OI Cao, Xiaoyan/0000-0001-7571-6482
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 337-FUEL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982804753
ER

PT J
AU Sadler, JM
   Nguyen, AP
   Kayea, RV
   La Scala, JJ
AF Sadler, Joshua M.
   Nguyen, Anh-Phuong
   Kayea, Ronald V., III
   La Scala, John J.
TI Synthesis, formulation, and characterizationi of biobased unsaturated
   polyester resin
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 [Sadler, Joshua M.; Nguyen, Anh-Phuong; Kayea, Ronald V., III; La Scala, John J.] Army Res Lab, Aberdeen Proving Ground, MD USA.
NR 0
TC 1
Z9 1
U1 1
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 148-CELL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982802574
ER

PT J
AU Servinsky, MD
   Byrd, CM
   Sumner, JJ
   Bentley, WE
AF Servinsky, Matthew D.
   Byrd, Christopher M.
   Sumner, James J.
   Bentley, William E.
TI Understanding intercellular signaling of biofilms in logistics fluids
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 USA, Sensors & Elect Devices Div, Res Lab, Adelphi, MD USA.
   Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
   Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, College Pk, MD 20742 USA.
   Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 222-BIOT
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982802105
ER

PT J
AU Shughrue, KM
   Hark, RR
   Remus, JJ
   Harmon, R
   Wise, MA
   East, LJ
   Gonzalez, J
   Oropeza, DD
AF Shughrue, Katrina M.
   Hark, Richard R.
   Remus, Jeremiah J.
   Harmon, Russell
   Wise, Michael A.
   East, Lucille J.
   Gonzalez, Jhanis
   Oropeza, Dayana D.
TI Analysis of the "conflict mineral" columbite-tantalite using
   laser-induced breakdown spectroscopy (LIBS) and laser ablation
   inductively coupled plasma mass spectrometry (LA-ICP-MS)
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Juniata Coll, Dept Chem, Huntingdon, PA 16652 USA.
   Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY USA.
   USA, Res Off, Res Lab, Res Triangle Pk, NC 27709 USA.
   Smithsonian Inst, Div Mineral, Washington, DC 20560 USA.
   Appl Spectra Inc, Fremont, CA USA.
   Univ Calif Berkeley, Lawrence Berkeley Lab, Environm Energy Technol Div, Berkeley, CA 94720 USA.
NR 0
TC 0
Z9 0
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 60-ANYL
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982801261
ER

PT J
AU Shur, O
   Szilvay, GR
   Blenner, MA
   Cropek, DM
   Banta, SA
AF Shur, Oren
   Szilvay, Geza R.
   Blenner, Mark A.
   Cropek, Donald M.
   Banta, Scott A.
TI Beta roll motifs as a novel scaffold for engineering biomolecular
   recognition
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Columbia Univ, New York, NY USA.
   Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA USA.
   Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
   USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61824 USA.
   VTT Tech Res Ctr, Espoo, Finland.
NR 0
TC 0
Z9 0
U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 511-BIOT
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982801961
ER

PT J
AU Stanzione, JF
   Strawhcker, KE
   Wool, RP
AF Stanzione, Joseph F., III
   Strawhcker, Kenneth E.
   Wool, Richard P.
TI Experimental observation of the Twinkling Fractal Theory of the glass
   transition
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Univ Delaware, Dept Chem Engn, Newark, DE USA.
   USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD USA.
NR 0
TC 1
Z9 1
U1 3
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 138-POLY
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982807337
ER

PT J
AU Sund, CJ
   Servinsky, MD
   Kiel, JT
   Sumner, JJ
AF Sund, Christian J.
   Servinsky, Matthew D.
   Kiel, James T.
   Sumner, James J.
TI Transcriptional analysis of pectin utilization in Clostridium
   acetobutylicum
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 [Sund, Christian J.; Servinsky, Matthew D.; Kiel, James T.; Sumner, James J.] USA, RDRL SEE O, Res Lab, Adelphi, MD USA.
RI sund, christian/G-3424-2013
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 224-BIOT
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982802107
ER

PT J
AU Swayze, MD
   Riegner, DE
   Thomas, MA
   Lachance, ZT
   Kaplan, SE
AF Swayze, Michael D.
   Riegner, Dawn E.
   Thomas, Mary Ann
   Lachance, Zach T.
   Kaplan, Sarah E.
TI Chemical warfare agent (CWA) surrogate detection by metal-organic
   frameworks as solid-phase microextraction (SPME) material
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 [Swayze, Michael D.; Riegner, Dawn E.; Thomas, Mary Ann; Lachance, Zach T.; Kaplan, Sarah E.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
NR 0
TC 0
Z9 0
U1 0
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 281-CHED
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982800304
ER

PT J
AU Wu, HC
   Tsao, CY
   Valdes, JJ
   Payne, GF
   Muro, S
   Bentley, WE
AF Wu, Hsuan-Chen
   Tsao, Chen-Yu
   Valdes, James J.
   Payne, Gregory F.
   Muro, Silvia
   Bentley, William E.
TI Toward a bacterial dirigible: Autonomous localization and actuation
SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Meeting Abstract
CT 241st National Meeting and Exposition of the American-Chemical-Society
   (ACS)
CY MAR 27-31, 2011
CL Anaheim, CA
SP Amer Chem Soc
C1 Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.
   Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
   Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA.
   USA, Engn Res & Dev Ctr, Edgewood, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0065-7727
J9 ABSTR PAP AM CHEM S
JI Abstr. Pap. Am. Chem. Soc.
PD MAR 27
PY 2011
VL 241
MA 155-BIOT
PG 1
WC Chemistry, Multidisciplinary
SC Chemistry
GA 782BO
UT WOS:000291982801984
ER

PT J
AU Miyata, T
   Harakuni, T
   Sugawa, H
   Sattabongkot, J
   Kato, A
   Tachibana, M
   Torii, M
   Tsuboi, T
   Arakawa, T
AF Miyata, Takeshi
   Harakuni, Tetsuya
   Sugawa, Hideki
   Sattabongkot, Jetsumon
   Kato, Aki
   Tachibana, Mayumi
   Torii, Motomi
   Tsuboi, Takafumi
   Arakawa, Takeshi
TI Adenovirus-vectored Plasmodium vivax ookinete surface protein, Pvs25, as
   a potential transmission-blocking vaccine
SO VACCINE
LA English
DT Article
DE Malaria transmission-blocking vaccine; Human adenovirus
ID MALARIA VACCINE; VIRAL VECTORS; MICE; IMMUNOGENICITY; IMMUNIZATION;
   ERADICATION; ANTIBODIES; FALCIPARUM; CANDIDATE; PROSPECTS
AB Adjuvants or delivery vehicles are essential components to expedite malaria vaccine development. In this study, replication-defective human adenovirus serotype 5 (rAd) was genetically engineered to express the Plasmodium vivax ookinete surface protein (OSP), Pvs25 (AdPvs25). BALB/c mice immunized with the AdPvs25 through various routes including intramuscular, subcutaneous and intranasal routes were analyzed for induction of antigen-specific transmission-blocking immunity. Parenteral but not mucosal immunization induced high serum immunoglobulin G (IgG) responses specific to P. vivax ookinetes isolated from P. vivax volunteer patients from Thailand. The membrane feeding assay revealed that antisera conferred a transmission blockade of up to 99% reduction in the average oocyst numbers per mosquito, while immunization with a rAd expressing Pfs25 from Plasmodium falciparum, a homolog of Pvs25, conferred only a background level of blockade, suggesting that a species-specific transmission-blocking immunity was induced. Vaccine efficacy of AdPvs25 was slightly higher than to a recombinant Pvs25 protein mixed with aluminum hydroxide, but less efficacious than the protein emulsified with incomplete Freund's adjuvant. This study, the first preclinical evaluation of adenovirus-vectored malaria OSPs, implicates a potential inclusion of malaria transmission-blocking vaccine antigens in viral vector systems. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Miyata, Takeshi; Harakuni, Tetsuya; Sugawa, Hideki; Arakawa, Takeshi] Univ Ryukyus, Trop Biosphere Res Ctr, COMB, Mol Microbiol Grp,Dept Trop Infect Dis, Okinawa 9030213, Japan.
   [Sugawa, Hideki] AMBiS Corp, Okinawa 9011202, Japan.
   [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
   [Kato, Aki; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan.
   [Tachibana, Mayumi; Torii, Motomi] Ehime Univ, Grad Sch Med, Dept Mol Parasitol, Toon, Ehime 7910295, Japan.
   [Arakawa, Takeshi] Univ Ryukyus, Grad Sch Med, Div Host Def & Vaccinol, Okinawa 9030213, Japan.
RP Arakawa, T (reprint author), Univ Ryukyus, Trop Biosphere Res Ctr, COMB, Mol Microbiol Grp,Dept Trop Infect Dis, 1 Senbaru, Okinawa 9030213, Japan.
EM tarakawa@comb.u-ryukyu.ac.jp
FU Founding Research Centers for Emerging and Reemerging Infectious
   Diseases from The Ministry of Education, Culture, Sports, Science and
   Technology, Japan (MEXT) [19406009, 20590425, 21022034]; Okinawa
   Industry Promotion Public Corporation; Institute of Tropical Medicine,
   Nagasaki University
FX We thank the staff of the Armed Forces Research Institute of Medical
   Sciences in Bangkok. Thailand, for their technical assistance. This work
   was supported by grants from the Program of Founding Research Centers
   for Emerging and Reemerging Infectious Diseases from The Ministry of
   Education, Culture, Sports, Science and Technology, Japan (MEXT);
   Grants-in-Aid for Scientific Research (19406009 and 20590425) and
   Scientific Research on Priority Areas (21022034) from MEXT; a grant from
   the Okinawa Industry Promotion Public Corporation; and the Cooperative
   Research Grant of the Institute of Tropical Medicine, Nagasaki
   University.
NR 38
TC 11
Z9 12
U1 2
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD MAR 24
PY 2011
VL 29
IS 15
BP 2720
EP 2726
DI 10.1016/j.vaccine.2011.01.083
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 745CE
UT WOS:000289140700011
PM 21315699
ER

PT J
AU Pang, YP
   Park, JG
   Wang, SH
   Vummenthala, A
   Mishra, RK
   McLaughlin, JE
   Di, R
   Kahn, JN
   Tumer, NE
   Janosi, L
   Davis, J
   Millard, CB
AF Pang, Yuan-Ping
   Park, Jewn Giew
   Wang, Shaohua
   Vummenthala, Anuradha
   Mishra, Rajesh K.
   McLaughlin, John E.
   Di, Rong
   Kahn, Jennifer Nielsen
   Tumer, Nilgun E.
   Janosi, Laszlo
   Davis, Jon
   Millard, Charles B.
TI Small-Molecule Inhibitor Leads of Ribosome-Inactivating Proteins
   Developed Using the Doorstop Approach
SO PLOS ONE
LA English
DT Article
ID RICIN-A-CHAIN; ESCHERICHIA-COLI O157-H7; SHIGA-LIKE TOXINS;
   X-RAY-STRUCTURE; TRANSITION-STATE; FIREFLY LUCIFERASE; ACTIVE-SITE;
   AMINO-ACIDS; LOOP RNA; IDENTIFICATION
AB Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the alpha-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis. Shiga-like toxins (Stx1 and Stx2), produced by Escherichia coli, are RIPs that cause outbreaks of foodborne diseases with significant morbidity and mortality. Ricin, produced by the castor bean plant, is another RIP lethal to mammals. Currently, no US Food and Drug Administration-approved vaccines nor therapeutics exist to protect against ricin, Shiga-like toxins, or other RIPs. Development of effective small-molecule RIP inhibitors as therapeutics is challenging because strong electrostatic interactions at the RIP center dot SRL interface make drug-like molecules ineffective in competing with the rRNA for binding to RIPs. Herein, we report small molecules that show up to 20% cell protection against ricin or Stx2 at a drug concentration of 300 nM. These molecules were discovered using the doorstop approach, a new approach to protein center dot polynucleotide inhibitors that identifies small molecules as doorstops to prevent an active-site residue of an RIP (e.g., Tyr80 of ricin or Tyr77 of Stx2) from adopting an active conformation thereby blocking the function of the protein rather than contenders in the competition for binding to the RIP. This work offers promising leads for developing RIP therapeutics. The results suggest that the doorstop approach might also be applicable in the development of other protein center dot polynucleotide inhibitors as antiviral agents such as inhibitors of the Z-DNA binding proteins in poxviruses. This work also calls for careful chemical and biological characterization of drug leads obtained from chemical screens to avoid the identification of irrelevant chemical structures and to avoid the interference caused by direct interactions between the chemicals being screened and the luciferase reporter used in screening assays.
C1 [Pang, Yuan-Ping; Park, Jewn Giew; Wang, Shaohua; Vummenthala, Anuradha; Mishra, Rajesh K.] Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN 55905 USA.
   [McLaughlin, John E.; Di, Rong; Kahn, Jennifer Nielsen; Tumer, Nilgun E.] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol & Pathol, New Brunswick, NJ 08903 USA.
   [Janosi, Laszlo; Davis, Jon; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA.
RP Pang, YP (reprint author), Mayo Clin, Comp Aided Mol Design Lab, Rochester, MN 55905 USA.
EM pang@mayo.edu; tumer@aesop.rutgers.edu; charles.b.millard@us.army.mil
RI McLaughlin, John/D-6966-2011; 
OI Pang, Yuan-Ping/0000-0003-0838-2560
FU United States Army Medical Research and Materiel Command
   [W81XWH-04-2-0001]; Mayo Foundation for Medical Education and Research;
   United States National Institute of Allergy and Infectious Diseases
   [1U01AI082120-01, R01AI072425]
FX This work was supported by the United States Army Medical Research and
   Materiel Command (W81XWH-04-2-0001 to YPP), the Mayo Foundation for
   Medical Education and Research (to YPP), and the United States National
   Institute of Allergy and Infectious Diseases (1U01AI082120-01 to YPP,
   NET and CBM; R01AI072425 to NET). The computational studies were
   supported in part by the University of Minnesota Supercomputing
   Institute. The funders had no role in the study design, data collection
   and analysis, decision to publish, or preparation of the manuscript. The
   opinions or assertions contained herein belong to the authors and are
   not necessarily the official views of the funders.
NR 70
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Z9 18
U1 1
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 24
PY 2011
VL 6
IS 3
AR e17883
DI 10.1371/journal.pone.0017883
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 740RG
UT WOS:000288811500012
PM 21455295
ER

PT J
AU Michalkova, A
   Gorb, L
   Hill, F
   Leszczynski, J
AF Michalkova, A.
   Gorb, L.
   Hill, F.
   Leszczynski, J.
TI Can the Gibbs Free Energy of Adsorption Be Predicted Efficiently and
   Accurately: An M05-2X DFT Study
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; ACTIVATED CARBON; ORGANIC POLLUTANTS;
   AQUEOUS-SOLUTIONS; INTERMOLECULAR COMPLEXES; NONCOVALENT INTERACTIONS;
   THERMOCHEMICAL KINETICS; SORPTION; SOOT; WATER
AB This study presents new insight into the prediction of partitioning of organic compounds between a carbon surface (soot) and water, and it also sheds light on the sluggish desorption of interacting molecules from activated and nonactivated carbon surfaces. This paper provides details about the structure and interactions of benzene, polycyclic aromatic hydrocarbons, and aromatic nitrocompounds with a carbon surface modeled by coronene using a density functional theory approach along with the M05-2X functional. The adsorption was studied in vacuum and from water solution. The molecules studied are physisorbed on the carbon surface. While the intermolecular interactions of benzene and hydrocarbons are governed by dispersion forces, nitrocompounds are adsorbed also due to quite strong electrostatic interactions with all types of carbon surfaces. On the basis of these results, we conclude that the method of prediction presented in this study allows one to approach the experimental level of accuracy in predicting thermodynamic parameters of adsorption on a carbon surface from the gas phase. The empirical modification of the polarized continuum model leads also to a quantitative agreement with the experimental data for the Gibbs free energy values of the adsorption from water solution.
C1 [Michalkova, A.; Leszczynski, J.] Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, Jackson, MS 39217 USA.
   [Gorb, L.] Badger Tech Serv LLC, Vicksburg, MS USA.
   [Hill, F.; Leszczynski, J.] USA, ERDC, Vicksburg, MS USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Interdisciplinary Nanotox Ctr, Dept Chem & Biochem, 1400 Lynch St,POB 17910, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
FU High Performance Computing Major Shared Resource Center at the ERDC
   (Vicksburg, MS); Office of Naval Research [N00034-03-1-0116]
FX This work was facilitated by support from the High Performance Computing
   Major Shared Resource Center at the ERDC (Vicksburg, MS) and the Office
   of Naval Research Grant No. N00034-03-1-0116. The use of trade, product,
   or firm names in this report is for descriptive purposes only and does
   not imply endorsement by the U.S. Government. Results in this study were
   funded and obtained from research conducted under the Environmental
   Quality Technology Program of the United States Army Corps of Engineers
   by the U.S. Army ERDC. Permission was granted by the Chief of Engineers
   to publish this information. The findings of this report are not to be
   construed as an official Department of the Army position unless so
   designated by other authorized documents.
NR 44
TC 13
Z9 13
U1 1
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD MAR 24
PY 2011
VL 115
IS 11
BP 2423
EP 2430
DI 10.1021/jp112240d
PG 8
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 735GH
UT WOS:000288400900041
PM 21361266
ER

PT J
AU Sahoo, S
   Husale, S
   Karna, S
   Nayak, SK
   Ajayan, PM
AF Sahoo, Sangeeta
   Husale, Sudhir
   Karna, Shashi
   Nayak, Saroj K.
   Ajayan, Pulickel M.
TI Controlled Assembly of Ag Nanoparticles and Carbon Nanotube Hybrid
   Structures for Biosensing
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID SILVER NANOPARTICLES; METAL NANOPARTICLES; SENSORS; ELECTRODEPOSITION;
   COMPOSITES; DECORATION; DEPOSITION; NANOWIRES; NETWORKS; CATALYST
AB Here we report a chemical-free, simple, and novel method in which a part from a silver-based anode is controllably used in a straightforward manner to produce silver nanoparticles (Ag NPs) in order to fabricate a controlled assembly of Ag NPs and single walled carbon nanotube (SWCNT) hybrid structures. The attachment and distribution of Ag NPs along SWCNTs have been investigated and characterized by field emission scanning electron microscopy (FESEM). We have achieved the decoration of SWCNTs with different densities of Ag NPs by changing the deposition time, the applied voltage, and the location of carbon nanotubes with respect to the anode. At low voltage, single silver nanoparticle is successfully attached at the open ends of SWCNTs whereas at high voltage, intermediate and full coverage densities of Ag NPs are observed. As voltage is further increased, fractals of Ag NPs along SWCNTs are observed. In addition, a device based on a Ag NPs SWNT hybrid structure is used for the label-free molecules immobilized on it. We believe that the proposed method can be used to decorate and/or assemble metal nanoparticles or fractal patterns along SWCNTs with different novel metals such as gold, silver, and copper and can be exploited in various sensitive applications for fundamental research and nanotechnology.
C1 [Sahoo, Sangeeta] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
   [Husale, Sudhir] Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02142 USA.
   [Karna, Shashi] USA, Res Lab, AMSRD ARL WM BD, Weapons & Mat Directorate, Aberdeen Proving Ground, MD 21005 USA.
   [Nayak, Saroj K.] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA.
   [Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA.
RP Sahoo, S (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
EM san_sahoo@yahoo.com; S.C.Husale@tnw.utwente.nl
FU RPI; IFC New York at RPI; Army Research Lab; NSF NSEC
FX Financial support was received from RPI, the IFC New York at RPI, Army
   Research Lab, and the NSF NSEC to pursue this work and is highly
   appreciated.
NR 27
TC 46
Z9 48
U1 2
U2 99
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD MAR 23
PY 2011
VL 133
IS 11
BP 4005
EP 4009
DI 10.1021/ja1093327
PG 5
WC Chemistry, Multidisciplinary
SC Chemistry
GA 741UF
UT WOS:000288889900059
PM 21348448
ER

PT J
AU Peterson, AM
   Jensen, RE
   Palmese, GR
AF Peterson, Amy M.
   Jensen, Robert E.
   Palmese, Giuseppe R.
TI Thermoreversible and remendable glass-polymer interface for
   fiber-reinforced composites
SO COMPOSITES SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Coupling agents; Functional composites; Fiber/matrix bond; Interphase
ID DIELS-ALDER REACTION; CHEMISTRY; INTERPHASE; THERMOSETS; STRENGTH;
   MATRIX; AGENTS; FURANS
AB Adhesion of the reinforcement to the polymer matrix is essential for load transfer from the polymer matrix to the reinforcement material in fiber-reinforced composites. The reversible Diels-Alder reaction between a furan-functionalized epoxy-amine thermosetting matrix with a maleimide-functionalized glass fiber was used to impart remendability at the polymer-glass interface for potential application in glass fiber-reinforced composites. At room temperature the Diels-Alder adduct is formed spontaneously and above 90 degrees C the adduct breaks apart to reform the original furan and maleimide moieties. Healing of the interface was investigated with single fiber microdroplet pull-out testing. Following complete failure of this interface, significant healing was observed, with some specimens recovering over 100% of the initial properties. Healing efficiency was not affected by the distance of displacement, with an overall average of 41% healing efficiency. Up to five healing cycles were successfully achieved. It is expected that a glass fiber-reinforced composite of maleimide-sized glass within a furan-functionalized network will demonstrate extension of fatigue life. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Peterson, Amy M.; Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
   [Jensen, Robert E.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, 3141 Chestnut St, Philadelphia, PA 19104 USA.
EM palmese@coe.drexel.edu
RI Peterson, Amy/A-2945-2012
OI Peterson, Amy/0000-0002-4612-0062
FU US Army Research Laboratory under the Army Materials Center of
   Excellence [W911NF-06-2-0013]; National Science Foundation
FX The authors from Drexel University wish to acknowledge the US Army
   Research Laboratory for financial support under the Army Materials
   Center of Excellence Program, Contract W911NF-06-2-0013. Amy Peterson is
   supported in part by a National Science Foundation Graduate Research
   Fellowship. The authors thank the US Army Research laboratory for use of
   the microdroplet single fiber pull-out testing apparatus.
NR 33
TC 35
Z9 35
U1 3
U2 44
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0266-3538
J9 COMPOS SCI TECHNOL
JI Compos. Sci. Technol.
PD MAR 22
PY 2011
VL 71
IS 5
BP 586
EP 592
DI 10.1016/j.compscitech.2010.11.022
PG 7
WC Materials Science, Composites
SC Materials Science
GA 745AU
UT WOS:000289137100003
ER

PT J
AU Cohen, SP
   Brown, C
   Kurihara, C
   Plunkett, A
   Nguyen, C
   Strassels, SA
AF Cohen, Steven P.
   Brown, Charlie
   Kurihara, Connie
   Plunkett, Anthony
   Conner Nguyen
   Strassels, Scott A.
TI Diagnoses and factors associated with medical evacuation and return to
   duty among nonmilitary personnel participating in military operations in
   Iraq and Afghanistan
SO CANADIAN MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; NONCARDIAC CHEST-PAIN; WORK; INJURY; WAR;
   CASUALTIES
AB Background: Nonmilitary personnel play an increasingly critical role in modern wars. Stark differences exist between the demographic characteristics, training and missions of military and nonmilitary members. We examined the differences in types of injury and rates of returning to duty among nonmilitary and military personnel participating in military operations in Iraq and Afghanistan.
   Methods: We collected data for nonmilitary personnel medically evacuated from military operations in Iraq and Afghanistan between 2004 and 2007. We compared injury categories and return-to-duty rates in this group with previously published data for military personnel and identified factors associated with return to duty.
   Results: Of the 2155 medically evacuated nonmilitary personnel, 74.7% did not return to duty. War-related injuries in this group accounted for 25.6% of the evacuations, the most common causes being combat-related injuries (55.4%) and musculoskeletal/spinal injuries (22.9%). Among individuals with nonwar-related injuries, musculoskeletal injuries accounted for 17.8% of evacuations. Diagnoses associated with the highest return-to-duty rates in the group of nonmilitary personnel were psychiatric diagnoses (15.6%) among those with war-related injuries and noncardiac chest or abdominal pain (44.0%) among those with non-war-related injuries. Compared with military personnel, nonmilitary personnel with war-related injuries were less likely to return to duty (4.4% v. 5.9%, p = 0.001) but more likely to return to duty after non-war-related injuries (32.5% v. 30.7%, p = 0.001).
   Interpretation: Compared with military personnel, nonmilitary personnel were more likely to be evacuated with non-war-related injuries but more likely to return to duty after such injuries. For evacuations because of war-related injuries, this trend was reversed.
C1 [Cohen, Steven P.; Brown, Charlie] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD 21218 USA.
   [Cohen, Steven P.; Kurihara, Connie] Walter Reed Army Med Ctr, Dept Surg, Anesthesia Serv, Washington, DC 20307 USA.
   [Plunkett, Anthony] 31st Combat Support Hosp, Dept Surg, Camp Dwyer, Afghanistan.
   [Conner Nguyen] Landstuhl Reg Med Ctr, Dept Surg, Landstuhl, Germany.
   [Strassels, Scott A.] Univ Texas Austin, Div Pharm Practice, Austin, TX 78712 USA.
RP Cohen, SP (reprint author), Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD 21218 USA.
EM scohen40@jhmi.edu
FU John P. Murtha Neuroscience and Pain Institute; US Army; Army Regional
   Anesthesia and Pain Medicine Initiative; US Department of Defense
FX This study was funded in part by a congressional grant from the John P.
   Murtha Neuroscience and Pain Institute, the US Army and the Army
   Regional Anesthesia and Pain Medicine Initiative.; Steven Cohen was paid
   for expert testimony in a lawsuit defending the US Department of Defense
   and has received speaker fees for a presentation at the Hong Kong
   Orthopedic Association 2010 annual meeting. No competing interests
   declared by the other authors.
NR 23
TC 5
Z9 5
U1 0
U2 3
PU CMA-CANADIAN MEDICAL ASSOC
PI OTTAWA
PA 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 3Y6, CANADA
SN 0820-3946
J9 CAN MED ASSOC J
JI Can. Med. Assoc. J.
PD MAR 22
PY 2011
VL 183
IS 5
BP E289
EP E295
DI 10.1503/cmaj.100244
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 742OL
UT WOS:000288953900015
PM 21324873
ER

PT J
AU Yildirim, ED
   Pappas, D
   Guceri, S
   Sun, W
AF Yildirim, Eda D.
   Pappas, Daphne
   Gueceri, Selcuk
   Sun, Wei
TI Enhanced Cellular Functions on Polycaprolactone Tissue Scaffolds by O-2
   Plasma Surface Modification
SO PLASMA PROCESSES AND POLYMERS
LA English
DT Article
DE osteoblast differentiation; oxygen plasma surface modification;
   polycaprolactone; surfaces; three-dimensional scaffolds; tissue
   engineering
ID ENGINEERING APPLICATIONS; OSTEOBLAST ADHESION; PROLIFERATION;
   DIFFERENTIATION; DEPOSITION; GROWTH; ATTACHMENT; PHENOTYPE; MEMBRANES;
   POLYMERS
AB This paper reports a study of using an oxygen-based plasma modification to alter physicochemical properties of three-dimensional (3D) PCL scaffolds and to improve mouse osteoblast cells attachment, proliferation, and osteoblastic differentiation. Different plasma modification times (1, 3, and 5-min) and their effects on surface physicochemical properties were measured by contact angle measurement, surface energy calculation (Owens-Wendth Method), surface chemistry (XPS), and the surface topography (AFM). The effect of oxygen-based plasma modification on attachment, proliferation, and osteoblastic differentiation were examined by shear flow assay, alamarBlue assay, scanning electron microscopy (SEM), and osteoblastic differentiation markers. Results of the contact angle measurement, total solid surface energy, surface chemistry, and roughness revealed that oxygen-based plasma modification increased surface hydrophilicity, total surface energy, total amount of oxygen containing groups, and the surface roughness. A positive effect of plasma modification on cell proliferation on 3D PCL scaffolds was observed at the osteoblastic differentiation stage which was evaluated by the alkaline phosphatase (ALP) activity, osteocalcin protein secretion, and calcium mineralization. The higher ALP activity and osteocalcin secretion were detected from the cells on 3-min plasma modified PCL surface compared to unmodified samples. The calcium mineralization and SEM micrographs data also showed that there was a higher mineralized matrix deposition on 3-min plasma modified PCL scaffolds compared to unmodified scaffolds. These results suggest that the 3-min plasma modification can accelerate differentiation phase of osteoblast through improving cell scaffold interaction.
C1 [Yildirim, Eda D.; Gueceri, Selcuk; Sun, Wei] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
   [Pappas, Daphne] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sun, W (reprint author), Drexel Univ, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA.
EM sunwei@drexel.edu
RI Luong-Van, Emma/A-8685-2012; 
OI Pappas, Daphne/0000-0002-5746-8873
NR 35
TC 31
Z9 32
U1 5
U2 22
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1612-8850
J9 PLASMA PROCESS POLYM
JI Plasma Process. Polym.
PD MAR 22
PY 2011
VL 8
IS 3
BP 256
EP 267
DI 10.1002/ppap.201000009
PG 12
WC Physics, Applied; Physics, Fluids & Plasmas; Physics, Condensed Matter;
   Polymer Science
SC Physics; Polymer Science
GA 743NK
UT WOS:000289024800010
ER

PT J
AU Rasko, DA
   Worsham, PL
   Abshire, TG
   Stanley, ST
   Bannan, JD
   Wilson, MR
   Langham, RJ
   Decker, RS
   Jiang, LX
   Read, TD
   Phillippy, AM
   Salzberg, SL
   Pop, M
   Van Ert, MN
   Kenefic, LJ
   Keim, PS
   Fraser-Liggett, CM
   Ravel, J
AF Rasko, David A.
   Worsham, Patricia L.
   Abshire, Terry G.
   Stanley, Scott T.
   Bannan, Jason D.
   Wilson, Mark R.
   Langham, Richard J.
   Decker, R. Scott
   Jiang, Lingxia
   Read, Timothy D.
   Phillippy, Adam M.
   Salzberg, Steven L.
   Pop, Mihai
   Van Ert, Matthew N.
   Kenefic, Leo J.
   Keim, Paul S.
   Fraser-Liggett, Claire M.
   Ravel, Jacques
TI Bacillus anthracis comparative genome analysis in support of the
   Amerithrax investigation
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
ID ASPARTYL-PHOSPHATE PHOSPHATASES; NUMBER TANDEM REPEATS; UNITED-STATES;
   SPORULATION; SUBTILIS; SEQUENCE; AMES; PLASMID; POLYMORPHISMS;
   TRANSCRIPTION
AB Before the anthrax letter attacks of 2001, the developing field of microbial forensics relied on microbial genotyping schemes based on a small portion of a genome sequence. Amerithrax, the investigation into the anthrax letter attacks, applied high-resolution whole-genome sequencing and comparative genomics to identify key genetic features of the letters' Bacillus anthracis Ames strain. During systematic microbiological analysis of the spore material from the letters, we identified a number of morphological variants based on phenotypic characteristics and the ability to sporulate. The genomes of these morphological variants were sequenced and compared with that of the B. anthracis Ames ancestor, the progenitor of all B. anthracis Ames strains. Through comparative genomics, we identified four distinct loci with verifiable genetic mutations. Three of the four mutations could be directly linked to sporulation pathways in B. anthracis and more specifically to the regulation of the phosphorylation state of Spo0F, a key regulatory protein in the initiation of the sporulation cascade, thus linking phenotype to genotype. None of these variant genotypes were identified in single-colony environmental B. anthracis Ames isolates associated with the investigation. These genotypes were identified only in B. anthracis morphotypes isolated from the letters, indicating that the variants were not prevalent in the environment, not even the environments associated with the investigation. This study demonstrates the forensic value of systematic microbiological analysis combined with whole-genome sequencing and comparative genomics.
C1 [Rasko, David A.; Jiang, Lingxia; Ravel, Jacques] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Inst Genome Sci, Baltimore, MD 21201 USA.
   [Worsham, Patricia L.; Abshire, Terry G.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
   [Stanley, Scott T.; Langham, Richard J.; Decker, R. Scott] Fed Bur Invest, Washington Field Off, Washington, DC 20535 USA.
   [Bannan, Jason D.; Wilson, Mark R.] Fed Bur Invest Lab, Quantico, VA 22134 USA.
   [Read, Timothy D.] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30322 USA.
   [Phillippy, Adam M.; Salzberg, Steven L.; Pop, Mihai] Univ Maryland, Dept Comp Sci, College Pk, MD 20742 USA.
   [Van Ert, Matthew N.; Kenefic, Leo J.; Keim, Paul S.] No Arizona Univ, Flagstaff, AZ 86011 USA.
   [Van Ert, Matthew N.; Kenefic, Leo J.; Keim, Paul S.] Translat Genom Res Inst, Flagstaff, AZ 85004 USA.
   [Fraser-Liggett, Claire M.] Univ Maryland, Sch Med, Dept Med, Inst Genome Sci, Baltimore, MD 21201 USA.
RP Ravel, J (reprint author), Univ Maryland, Sch Med, Dept Microbiol & Immunol, Inst Genome Sci, Baltimore, MD 21201 USA.
EM jravel@som.umaryland.edu
RI Keim, Paul/A-2269-2010; Read, Timothy/E-6240-2011; Salzberg,
   Steven/F-6162-2011; Pop, Mihai/A-7987-2013; 
OI Salzberg, Steven/0000-0002-8859-7432; Pop, Mihai/0000-0001-9617-5304;
   Ravel, Jacques/0000-0002-0851-2233; Fraser, Claire/0000-0003-1462-2428;
   David, Rasko/0000-0002-7337-7154
FU Department of Justice [J-FBI-02-016]; National Institute of Allergy and
   Infectious Diseases, National Institutes of Health [N01-AI15447];
   National Science Foundation [MCB-202304]
FX This work was jointly supported by federal funds from the Department of
   Justice under Contract J-FBI-02-016; the National Institute of Allergy
   and Infectious Diseases, National Institutes of Health, under Contract
   N01-AI15447; and National Science Foundation Small Grant for Exploratory
   Research MCB-202304.
NR 35
TC 70
Z9 75
U1 1
U2 17
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAR 22
PY 2011
VL 108
IS 12
BP 5027
EP 5032
DI 10.1073/pnas.1016657108
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 739JC
UT WOS:000288712200064
PM 21383169
ER

PT J
AU Dhawan, A
   Du, Y
   Batchelor, D
   Wang, HN
   Leonard, D
   Misra, V
   Ozturk, M
   Gerhold, MD
   Vo-Dinh, T
AF Dhawan, Anuj
   Du, Yan
   Batchelor, Dale
   Wang, Hsin-Neng
   Leonard, Donovon
   Misra, Veena
   Ozturk, Mehmet
   Gerhold, Michael D.
   Vo-Dinh, Tuan
TI Hybrid Top-Down and Bottom-Up Fabrication Approach for Wafer-Scale
   Plasmonic Nanoplatforms
SO SMALL
LA English
DT Article
ID ENHANCED RAMAN-SCATTERING; SILVER ELECTRODE; SURFACE; SPECTROSCOPY;
   NANOPARTICLES; MOLECULES; PYRIDINE; SPECTRA; ARRAYS
C1 [Dhawan, Anuj; Wang, Hsin-Neng; Vo-Dinh, Tuan] Duke Univ, Dept Biomed Engn, Fitzpatrick Inst Photon, Durham, NC 27706 USA.
   [Dhawan, Anuj; Wang, Hsin-Neng; Vo-Dinh, Tuan] Duke Univ, Dept Chem, Fitzpatrick Inst Photon, Durham, NC 27706 USA.
   [Du, Yan; Misra, Veena; Ozturk, Mehmet] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
   [Batchelor, Dale] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
   [Leonard, Donovon] Appalachian State Univ, Dept Phys & Astron, Boone, NC 28608 USA.
   [Dhawan, Anuj; Gerhold, Michael D.] USA, Div Elect, Res Off, Durham, NC USA.
RP Vo-Dinh, T (reprint author), Duke Univ, Dept Biomed Engn, Fitzpatrick Inst Photon, Durham, NC 27706 USA.
EM tuan.vodinh@duke.edu
RI Wang, Hsin-Neng/D-9631-2013
FU US Army Research Office; National Research Council; National Institutes
   of Health [R01 EB006201, R01 ES014774]
FX The authors would like to thank the sponsors of this work - US Army
   Research Office, National Research Council, and the National Institutes
   of Health (Grants R01 EB006201 and R01 ES014774). We would also like to
   thank Dr. Harris at SEMATECH consortia for providing support for this
   work.
NR 18
TC 9
Z9 9
U1 2
U2 10
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1613-6810
J9 SMALL
JI Small
PD MAR 21
PY 2011
VL 7
IS 6
BP 727
EP 731
DI 10.1002/smll.201002186
PG 5
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 738AZ
UT WOS:000288613000004
PM 21425456
ER

PT J
AU DeSilva, AW
   Vunni, GB
AF DeSilva, A. W.
   Vunni, G. B.
TI Electrical conductivity of dense Al, Ti, Fe, Ni, Cu, Mo, Ta, and W
   plasmas
SO PHYSICAL REVIEW E
LA English
DT Article
ID ALUMINUM PLASMAS; TUNGSTEN; RESISTIVITY; TRANSITION; COPPER; METALS;
   STATE
AB We report measurements of electrical conductivity of eight metals in the plasma state at densities ranging from 0.002 to 0.5 times solid density, and with internal energy from 2 to 30 kJ/gm. Data are presented as functions of internal energy and specific volume. Conductivity is observed to fall as the plasma expands for fixed internal energy, and for all but tantalum and titanium shows a minimum at approximately 0.01 times solid density, followed by an increase as the density decreases further.
C1 [DeSilva, A. W.] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA.
   [Vunni, G. B.] USA, Res Lab, Aberdeen Proving Ground, MD 20005 USA.
RP DeSilva, AW (reprint author), Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA.
FU US Army Research Laboratory, Aberdeen, MD
FX This work was supported by the US Army Research Laboratory, Aberdeen,
   MD.
NR 18
TC 17
Z9 18
U1 0
U2 8
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1539-3755
J9 PHYS REV E
JI Phys. Rev. E
PD MAR 18
PY 2011
VL 83
IS 3
AR 037402
DI 10.1103/PhysRevE.83.037402
PN 2
PG 4
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA 737AM
UT WOS:000288538600009
PM 21517633
ER

PT J
AU Hemmert, AC
   Otto, TC
   Chica, RA
   Wierdl, M
   Edwards, JS
   Lewis, SL
   Edwards, CC
   Tsurkan, L
   Cadieux, CL
   Kasten, SA
   Cashman, JR
   Mayo, SL
   Potter, PM
   Cerasoli, DM
   Redinbo, MR
AF Hemmert, Andrew C.
   Otto, Tamara C.
   Chica, Roberto A.
   Wierdl, Monika
   Edwards, Jonathan S.
   Lewis, Steven L.
   Edwards, Carol C.
   Tsurkan, Lyudmila
   Cadieux, C. Linn
   Kasten, Shane A.
   Cashman, John R.
   Mayo, Stephen L.
   Potter, Philip M.
   Cerasoli, Douglas M.
   Redinbo, Matthew R.
TI Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism
   Enzyme
SO PLOS ONE
LA English
DT Article
ID ANHYDRIDE HYDROLASE ACTIVITY; HUMAN BUTYRYLCHOLINESTERASE;
   ACETYLCHOLINESTERASE; INHIBITION; KINETICS; CARBOXYLESTERASES;
   REACTIVATION; EXPRESSION; CATALYSIS; TARGETS
AB Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activity into the human drug metabolism enzyme carboxylesterase 1. Using crystal structures of the target enzyme in complex with nerve agent as a guide, a pair of histidine and glutamic acid residues were designed proximal to the enzyme's native catalytic triad. The resultant variant protein demonstrated significantly increased rates of reactivation following exposure to sarin, soman, and cyclosarin. Importantly, the addition of these residues did not alter the high affinity binding of nerve agents to this protein. Thus, using two amino acid substitutions, a novel enzyme was created that efficiently converted a group of hemisubstrates, compounds that can start but not complete a reaction cycle, into bona fide substrates. Such approaches may lead to novel countermeasures for nerve agent poisoning.
C1 [Hemmert, Andrew C.; Edwards, Jonathan S.; Lewis, Steven L.; Redinbo, Matthew R.] Univ N Carolina, Dept Biochem Biophys & Chem, Chapel Hill, NC 27515 USA.
   [Otto, Tamara C.; Cadieux, C. Linn; Kasten, Shane A.; Cerasoli, Douglas M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Chica, Roberto A.; Mayo, Stephen L.] CALTECH, Dept Biol & Chem, Pasadena, CA 91125 USA.
   [Wierdl, Monika; Edwards, Carol C.; Tsurkan, Lyudmila; Potter, Philip M.] St Jude Childrens Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA.
   [Cashman, John R.] Human BioMol Res Inst, San Diego, CA USA.
RP Hemmert, AC (reprint author), Univ N Carolina, Dept Biochem Biophys & Chem, Chapel Hill, NC 27515 USA.
EM redinbo@unc.edu
RI Potter, Philip/J-4515-2013
FU National Institutes of Health through National Institute of Neurological
   Disorders and Stroke [UO1 NS58089, UO1 NS058038]; American Lebanese and
   Syrian Associated Charities (ALSAC); St. Jude Children's Research
   Hospital
FX This work was funded by the National Institutes of Health CounterACT
   Program through the National Institute of Neurological Disorders and
   Stroke (UO1 NS58089, MRR; UO1 NS058038, JRC). This work was also
   supported by the American Lebanese and Syrian Associated Charities
   (ALSAC) and St. Jude Children's Research Hospital. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
NR 30
TC 8
Z9 8
U1 3
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 18
PY 2011
VL 6
IS 3
AR e17441
DI 10.1371/journal.pone.0017441
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 737CD
UT WOS:000288545100014
PM 21445272
ER

PT J
AU Cory, MG
   Taylor, DE
   Bunte, SW
   Runge, K
   Vasey, JL
   Burns, DS
AF Cory, Marshall G.
   Taylor, DeCarlos E.
   Bunte, Steven W.
   Runge, Keith
   Vasey, Joseph L.
   Burns, Douglas S.
TI Theoretical Methodology for Prediction of Tropospheric Oxidation of
   Dimethyl Phosphonate and Dimethyl Methylphosphonate
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID GAS-PHASE REACTIONS; DIRECT DYNAMICS CALCULATIONS; MOLECULAR-ORBITAL
   METHODS; RATE-CONSTANT; APPROXIMATION; SURFACES; HYDROGEN
AB Rate constants for the reactions of OH radicals with dimethyl phosphonate [DMHP, (CH(3)O)(2)P(O)H] and dimethyl methylphosphonate [DMMP, (CH(3)O)(2)P(O)CH(3)] have been calculated by ab initio structural methods and semiclassical dynamics modeling and compared with experimental measurements over the temperature range 250-350 K. The structure and energetics of reactants and transition structures are determined for all hydrogen atom abstraction pathways that initiate the atmospheric oxidation mechanism. Structures are obtained at the CCSD/6-31++G** level of chemical theory, and the height of the activation barrier is determined by a variant of the G2MP2 method. A Transfer Hamiltonian is used to compute the minimum energy path in the neighborhood of the transition state (TS). This calculation provides information about the curvature of the potential energy surface in the neighborhood of the TS, as well as the internal forces that are needed by the semiclassical flux-flux autocorrelation function (SCFFAF) dynamics model used to compute the temperature-dependent reaction rate constants for the various possible abstraction pathways. The computed temperature-dependent rate curves frequently lie within the experimental error bars.
C1 [Cory, Marshall G.; Vasey, Joseph L.; Burns, Douglas S.] ENSCO Inc, Melbourne, FL 32940 USA.
   [Taylor, DeCarlos E.; Bunte, Steven W.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA.
   [Runge, Keith] BWD Associates LLC, Gainesville, FL 32653 USA.
RP Burns, DS (reprint author), ENSCO Inc, 4849 N Wickham Rd, Melbourne, FL 32940 USA.
EM burns.douglas@ensco.com
FU United States Air Force
FX This work was supported by the United States Air Force. While this
   research has been funded by this agency, the results and content of this
   publication do not necessarily reflect the views and opinions of the
   funding agency.
NR 34
TC 3
Z9 3
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD MAR 17
PY 2011
VL 115
IS 10
BP 1946
EP 1954
DI 10.1021/jp107804m
PG 9
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 731NE
UT WOS:000288113200023
PM 21338166
ER

PT J
AU Kaittanis, C
   Santra, S
   Santiesteban, OJ
   Henderson, TJ
   Perez, JM
AF Kaittanis, Charalambos
   Santra, Santimukul
   Santiesteban, Oscar J.
   Henderson, Terry J.
   Perez, J. Manuel
TI The Assembly State between Magnetic Nanosensors and Their Targets
   Orchestrates Their Magnetic Relaxation Response
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID GOLD NANOPARTICLE PROBES; MOLECULAR-INTERACTIONS; COLORIMETRIC
   DETECTION; SILVER NANOPARTICLES; BACILLUS-ANTHRACIS; CHOLERA-TOXIN;
   ONE-STEP; DNA; SEQUENCES; POLYNUCLEOTIDES
AB The target-induced clustering of magnetic nanoparticles is typically used for the identification of clinically relevant targets and events. A decrease in the water proton transverse NMR relaxation time, or T(2), is observed upon clustering, allowing the sensitive and accurate detection of target molecules. We have discovered a new mechanistically unique nanoparticle-target interaction resulting in a T(2) increase and demonstrate herein that this increase, and its associated r(2) relaxivity decrease, are also observed upon the interaction of the nanoparticles with ligands or molecular entities. Small molecules, proteins, and a 15-bp nucleic acid sequence were chemically conjugated to polyacrylic-acid-coated iron oxide nanoparticles, and all decreased the original nanoparticle r(2) value. Further experiments established that the r(2) decrease was inversely proportional to the number of ligands bound to the nanoparticle and the molecular weight of the bound ligand. Additional experiments revealed that the T(2)-increasing mechanism was kinetically faster than the conventional clustering mechanism. Most importantly, under conditions that result in T(2) increases, as little as 5.3 fmol of Bacillus anthracis plasmid DNA (pX01 and pX02), 8 pmol of the cholera toxin B subunit (Ctb), and even a few cancer cells in blood were detected. Transition from the binding to the clustering mechanism was observed in the carbohydrate-, Ctb-, and DNA-sensing systems, simply by increasing the target concentration significantly above the nanoparticle concentration, or using Ctb in its pentameric form as opposed to its monomer. Collectively, these results demonstrate that the molecular architectures resulting from the interaction between magnetic nanosensors and their targets directly govern water proton NMR relaxation. We attribute the observed T(2) increases to the bound target molecules partially obstructing the diffusion of solvent water molecules through the superparamagnetic iron oxide nanoparticles' outer relaxation spheres. Finally, we anticipate that this novel interaction can be incorporated into new clinical and field detection applications, due to its faster kinetics relative to the conventional nanoparticle-clustering assays.
C1 [Kaittanis, Charalambos; Santra, Santimukul; Perez, J. Manuel] Univ Cent Florida, Coll Med, Nanosci Technol Ctr, Orlando, FL 32826 USA.
   [Santiesteban, Oscar J.] Univ Cent Florida, Coll Med, Dept Chem, Orlando, FL 32826 USA.
   [Perez, J. Manuel] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32826 USA.
   [Henderson, Terry J.] USA, Edgewood Chem Biol Ctr, Biosci Div, Aberdeen Proving Ground, MD 21010 USA.
RP Perez, JM (reprint author), Univ Cent Florida, Coll Med, Nanosci Technol Ctr, 12424 Res Pkwy,Suite 400, Orlando, FL 32826 USA.
EM jmperez@mail.ucf.edu
FU NIH [GM084331]
FX This study was supported by the NIH grant GM084331 awarded to J.M.P.
NR 52
TC 25
Z9 25
U1 4
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD MAR 16
PY 2011
VL 133
IS 10
BP 3668
EP 3676
DI 10.1021/ja1109584
PG 9
WC Chemistry, Multidisciplinary
SC Chemistry
GA 735JK
UT WOS:000288410100067
PM 21341659
ER

PT J
AU Pawlowski, DR
   Metzger, DJ
   Raslawsky, A
   Howlett, A
   Siebert, G
   Karalus, RJ
   Garrett, S
   Whitehouse, CA
AF Pawlowski, David R.
   Metzger, Daniel J.
   Raslawsky, Amy
   Howlett, Amy
   Siebert, Gretchen
   Karalus, Richard J.
   Garrett, Stephanie
   Whitehouse, Chris A.
TI Entry of Yersinia pestis into the Viable but Nonculturable State in a
   Low-Temperature Tap Water Microcosm
SO PLOS ONE
LA English
DT Article
ID NON-CULTURABLE STATE; ESCHERICHIA-COLI; VIBRIO-VULNIFICUS;
   RESUSCITATION; BACTERIA; SURVIVAL; CELLS; STARVATION; VIRULENCE; PLAGUE
AB Yersinia pestis, the causative agent of plague, has caused several pandemics throughout history and remains endemic in the rodent populations of the western United States. More recently, Y. pestis is one of several bacterial pathogens considered to be a potential agent of bioterrorism. Thus, elucidating potential mechanisms of survival and persistence in the environment would be important in the event of an intentional release of the organism. One such mechanism is entry into the viable but non-culturable (VBNC) state, as has been demonstrated for several other bacterial pathogens. In this study, we showed that Y. pestis became nonculturable by normal laboratory methods after 21 days in a low-temperature tap water microcosm. We further show evidence that, after the loss of culturability, the cells remained viable by using a variety of criteria, including cellular membrane integrity, uptake and incorporation of radiolabeled amino acids, and protection of genomic DNA from DNase I digestion. Additionally, we identified morphological and ultrastructural characteristics of Y. pestis VBNC cells, such as cell rounding and large periplasmic spaces, by electron microscopy, which are consistent with entry into the VBNC state in other bacteria. Finally, we demonstrated resuscitation of a small number of the non-culturable cells. This study provides compelling evidence that Y. pestis persists in a low-temperature tap water microcosm in a viable state yet is unable to be cultured under normal laboratory conditions, which may prove useful in risk assessment and remediation efforts, particularly in the event of an intentional release of this organism.
C1 [Pawlowski, David R.; Raslawsky, Amy; Howlett, Amy; Siebert, Gretchen; Karalus, Richard J.] CUBRC Inc, Buffalo, NY USA.
   [Garrett, Stephanie; Whitehouse, Chris A.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
   [Pawlowski, David R.; Metzger, Daniel J.; Karalus, Richard J.] SUNY Buffalo, Dept Microbiol & Immunol, Buffalo, NY 14260 USA.
RP Pawlowski, DR (reprint author), CUBRC Inc, Buffalo, NY USA.
EM pawlowski@cubrc.org
FU CUBRC [00291.01]; USAMRIID [114509]; Oak Ridge Institute for Science and
   Education
FX The authors acknowledge the CUBRC Internal Research and Development
   program (no. 00291.01) and the USAMRIID In-House Laboratory Research
   program (no. 114509) for financial support. This research was supported
   in part by an appointment to the Student Research Participation Program
   at USAMRIID by the Oak Ridge Institute for Science and Education through
   an interagency agreement between the U.S. Department of Energy and the
   United States Army Medical Research and Materiel Command. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
NR 44
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U1 3
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 16
PY 2011
VL 6
IS 3
AR e17585
DI 10.1371/journal.pone.0017585
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 736SI
UT WOS:000288514000003
PM 21436885
ER

PT J
AU Burgess, EB
AF Burgess, Edwin B.
TI Nothing Less Than War: A New History of America's Entry into World War
   I.
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD MAR 15
PY 2011
VL 136
IS 5
BP 124
EP 125
PG 2
WC Information Science & Library Science
SC Information Science & Library Science
GA 735LR
UT WOS:000288416600147
ER

PT J
AU Mantey, K
   Nayfeh, MH
   Al-Hreish, B
   Boparai, J
   Kumar, A
   Stephenson, LD
   Nelson, AJ
   Alrokayan, SA
   Abu-Salah, KM
AF Mantey, Kevin
   Nayfeh, Munir H.
   Al-Hreish, Bahjat
   Boparai, Jack
   Kumar, Ashok
   Stephenson, Larry D.
   Nelson, Andrew J.
   Alrokayan, Salman A.
   Abu-Salah, Khalid M.
TI Silicon nanoparticle-functionalized fiberglass pads for sampling
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID FILMS; COMPOSITES
AB We used wet treatment to immobilize luminescent silicon nanoparticles on industrial glass fibers to impart optical and chemical functions to the fiber. Carpets or pads consisting of thousands of fibers are processed in parallel, enhancing the sensitivity of detection and the sampled volume. Treated pads exhibit strong luminescence, characteristic of the luminescence of the particles; showing no shift, broadening, or reduction of quantum efficiency. We demonstrate that drawing material by the pad due to physical adsorption can be reversed. We also demonstrate that allylamine can be covalently attached by photoinduced irradiation reactions, which results in imprinting the amine emission spectrum, providing spectral recognition. The imprint accompanied with a blue-shifting of the luminescence spectrum of the probe, allowing examination of the effect of termination on the nanoparticle structure. The shift is found to be consistent with an increase in the bandgap of the Si nanoparticle and is consistent with Quantum Monte Carlo calculations. In addition to sampling, the nano probe pad has the potential to enable a variety of biomedical applications through subsequent attachment. (C) 2011 American Institute of Physics. [doi:10.1063/1.3563535]
C1 [Mantey, Kevin; Nayfeh, Munir H.] Univ Illinois, Dept Phys, Urbana, IL 61801 USA.
   [Al-Hreish, Bahjat; Boparai, Jack] Nanosi Adv Technoloies Inc, Champaign, IL 61820 USA.
   [Kumar, Ashok; Stephenson, Larry D.; Nelson, Andrew J.] ERDC CERL, Champaign, IL 61826 USA.
   [Alrokayan, Salman A.; Abu-Salah, Khalid M.] KSU, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia.
RP Nayfeh, MH (reprint author), Univ Illinois, Dept Phys, 1110 W Green St, Urbana, IL 61801 USA.
EM m-nayfeh@uiuc.edu
FU NSF [ATM 08-02-499]; ERDC-CERL; Centre of Excellence in Biotechnology
   Research of King Saud University [CEBR 02]
FX This work was supported partially by the NSF (Grant ATM 08-02-499), the
   ERDC-CERL and the Centre of Excellence in Biotechnology Research of King
   Saud University, (Research Project No. CEBR 02).
NR 13
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U1 2
U2 15
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD MAR 15
PY 2011
VL 109
IS 6
AR 064321
DI 10.1063/1.3563535
PG 4
WC Physics, Applied
SC Physics
GA 745EY
UT WOS:000289149900127
ER

PT J
AU Groh, D
   Slough, WJ
   Pandey, R
   Karna, SP
   Dandekar, D
AF Groh, David
   Slough, William J.
   Pandey, Ravindra
   Karna, Shashi P.
   Dandekar, Dattatraya
TI Elastic properties of MgxTi1-xB2(0 <= x <= 1) studied by
   first-principles calculations
SO PHYSICAL REVIEW B
LA English
DT Article
ID EQUATION-OF-STATE; TITANIUM DIBORIDE; ELECTRONIC-PROPERTIES;
   SUPERCONDUCTING MGB2; RAY-DIFFRACTION; SHOCK-WAVE; AB-INITIO; TIB2;
   CONSTANTS; TEMPERATURE
AB The elastic properties, including elastic constants, bulk, and shear moduli, and anisotropic index of hexagonal MgxTi1-xB2 (0 <= x <= 1) are obtained using a first-principles density-functional-theory method. A difference in chemical bonding occurs between Ti-rich and Mg-rich diborides, leading to significantly different elastic properties: a small elastic anisotropy with relatively large bulk and shear moduli for Ti-rich diborides with x < 0.25, and a large elastic anisotropy and relatively small bulk and shear moduli for Mg-rich diborides with x > 0.25. The calculated results reveal a dominant role of the interplanar metal-metal bonds in predicting the extent of shear elastic anisotropy in MgxTi1-xB2 (0 <= x <= 1).
C1 [Groh, David; Slough, William J.; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
   [Karna, Shashi P.; Dandekar, Dattatraya] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Groh, D (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA.
EM pandey@mtu.edu; datta.dandekar@us.army.mil
FU RDECOM-ARL: Army Research Laboratory [W911NF-07-D-0001,
   W911NF-09-2-0026]
FX Helpful discussions with Manuel Recio are acknowledged. This work was
   partially supported by the RDECOM-ARL: Army Research Laboratory through
   Contracts No. W911NF-07-D-0001 and No. W911NF-09-2-0026.
NR 60
TC 8
Z9 8
U1 2
U2 15
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 1098-0121
J9 PHYS REV B
JI Phys. Rev. B
PD MAR 15
PY 2011
VL 83
IS 11
AR 115122
DI 10.1103/PhysRevB.83.115122
PG 6
WC Physics, Condensed Matter
SC Physics
GA 735BB
UT WOS:000288387300003
ER

PT J
AU Valiyaveettil, M
   Alamneh, Y
   Rezk, P
   Biggemann, L
   Perkins, MW
   Sciuto, AM
   Doctor, BP
   Nambiar, MP
AF Valiyaveettil, Manojkumar
   Alamneh, Yonas
   Rezk, Peter
   Biggemann, Lionel
   Perkins, Michael W.
   Sciuto, Alfred M.
   Doctor, Bhupendra P.
   Nambiar, Madhusoodana P.
TI Protective efficacy of catalytic bioscavenger, paraoxonase 1 against
   sarin and soman exposure in guinea pigs
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Chemical warfare nerve agents; Sarin; Soman; Catalytic bioscavenger;
   Paraoxonase 1
ID HUMAN SERUM PARAOXONASE; MICROINSTILLATION INHALATION EXPOSURE;
   ORGANOPHOSPHATE TOXICITY; PON1 STATUS; ACETYLCHOLINESTERASE ACTIVITY;
   RESPIRATORY DYNAMICS; NERVE AGENTS; EXPRESSION; RABBIT; PURIFICATION
AB Human paraoxonase 1 (PON1) has been portrayed as a catalytic bioscavenger which can hydrolyze large amounts of chemical warfare nerve agents (CWNAs) and organophosphate (OP) pesticides compared to the stoichiometric bioscavengers such as butyrylcholinesterase. We evaluated the protective efficacy of purified human and rabbit serum PON1 against nerve agents sarin and soman in guinea pigs. Catalytically active PON1 purified from human and rabbit serum was intravenously injected to guinea pigs, which were 30 min later exposed to 1.2 x LCt(50) sarin or soman using a microinstillation inhalation exposure technology. Pre-treatment with 5 units of purified human and rabbit serum PON1 showed mild to moderate increase in the activity of blood PON1, but significantly increased the survival rate with reduced symptoms of CWNA exposure. Although PON1 is expected to be catalytic, satin and soman exposure resulted in a significant reduction in blood PON1 activity. However, the blood levels of PON1 in pre-treated animals after exposure to nerve agent were higher than that of untreated control animals. The activity of blood acetylcholinesterase and butyrylcholinesterase and brain acetylcholinesterase was significantly higher in PON1 pre-treated animals and were highly correlated with the survival rate. Blood O(2) saturation, pulse rate and respiratory dynamics were normalized in animals treated with PON1 compared to controls. These results demonstrate that purified human and rabbit serum PON1 significantly protect against satin and soman exposure in guinea pigs and support the development of PON1 as a catalytic bioscavenger for protection against lethal exposure to CWNAs. Published by Elsevier Inc.
C1 [Valiyaveettil, Manojkumar; Alamneh, Yonas; Biggemann, Lionel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
   [Rezk, Peter; Perkins, Michael W.; Sciuto, Alfred M.] USA, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
RP Valiyaveettil, M (reprint author), Walter Reed Army Inst Res, Closed Head Injury Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM m.valiyaveettil@amedd.army.mil; madhu-soodana.nambiar@amedd.army.mil
FU Defense Threat Reduction Agency (DTRA) [1.D0017_08_WR_C]
FX This work was supported by funding from Defense Threat Reduction Agency
   (DTRA) Grant #1.D0017_08_WR_C.
NR 60
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U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAR 15
PY 2011
VL 81
IS 6
BP 800
EP 809
DI 10.1016/j.bcp.2010.12.024
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 730AX
UT WOS:000287996900012
PM 21219877
ER

PT J
AU D'Amore, DV
   Bonzey, NS
   Berkowitz, J
   Ruegg, J
   Bridgham, S
AF D'Amore, David V.
   Bonzey, Nicholas S.
   Berkowitz, Jacob
   Rueegg, Janine
   Bridgham, Scott
TI Holocene soil-geomorphic surfaces influence the role of salmon-derived
   nutrients in the coastal temperate rainforest of Southeast Alaska
SO GEOMORPHOLOGY
LA English
DT Article
DE Soils; Alluvial terrace; Pedology; Salmon-derived nutrients; Nitrogen
   isotopes
ID ELEMENTS TRANSPORTED UPSTREAM; NORTH PACIFIC COAST; RIPARIAN FOREST;
   STREAM PRODUCTIVITY; TERRESTRIAL ECOSYSTEMS; DELTA-C-13 EVIDENCE;
   WESTERN WASHINGTON; BRITISH-COLUMBIA; LATE-PLEISTOCENE; GLACIER BAY
AB The influence of salmon-derived nutrients (SDN) is widely accepted as a potential factor in the maintenance of aquatic and terrestrial productivity in North American Coastal rainforests. Holocene alluvial landforms are intimately connected with the return of anadromous salmon, but the influence of the soils that occupy these landforms and support this important terrestrial-aquatic ecological coupling have not been examined in SDN studies. We used paleo-ecologic information, soil resource inventories and measurements of soil morphology to construct a soil-geomorphic model for alluvial landforms along salmon spawning channels on Prince of Wales Island, Southeast Alaska, USA. Post-glacial sea-level rise, crustal uplift and subsidence combined with Holocene sediment deposition have formed alluvial terraces and floodplains along rivers on Prince of Wales Island. These alluvial landforms have soils that are mapped as Entisols (Tonowek soil series) and Spodosols (Tuxekan soil series). We propose a soil-geomorphic model where the Spodosols located on terraces are estimated to derive from sediments deposited after the stabilization of landscape approximately 8 kybp to 6 kybp. The stability of these soils is reflected through mature soil development with organic matter accumulation and podzolization. Our model identifies Entisols on floodplains developed from alluvial deposition in the latter Holocene that have soil morphologic features consistent with recent deposition and limited soil development. We used this soil-geomorphic model to test the hypothesis that the terrestrial end-member value commonly used to quantify nitrogen (N) loading on soils through stable isotope analysis differs by soil type and found that the two soil types had significantly different N isotopic (delta N-15) values more consistent with soil development than SON loading. The use of a soil-geomorphic model provides a means to stratify alluvial landforms and constrain the natural variability encountered in studies of riparian nutrient cycles associated with the feedbacks between SON and terrestrial ecosystems to improve estimates of the fate of SDN in soils and vegetation. Published by Elsevier B.V.
C1 [D'Amore, David V.] US Forest Serv, USDA, Pacific NW Res Stn, Juneau, AK 99801 USA.
   [Bonzey, Nicholas S.] Virginia Polytech Inst & State Univ, Dept Forest Resources & Environm Conservat, Blacksburg, VA 24601 USA.
   [Berkowitz, Jacob] US Army Corps Engineers, Environm Res & Dev Ctr, Vicksburg, MS USA.
   [Rueegg, Janine] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA.
   [Bridgham, Scott] Univ Oregon, Ctr Ecol & Evolutionary Biol, Eugene, OR USA.
   [Bridgham, Scott] Univ Oregon, Environm Studies Program, Eugene, OR USA.
RP D'Amore, DV (reprint author), US Forest Serv, USDA, Pacific NW Res Stn, Juneau, AK 99801 USA.
EM ddamore@fs.fed.us; nbonzey@vt.edu; jacob.f.berkowitz@usace.army.mil;
   jrueegg@nd.edu; bridgham@uoregon.edu
FU USDA-CSREES [2006-35101-16566]
FX We would like to acknowledge the comments and suggestions of Joe
   Wheaton, Jack Vitek, and two anonymous reviewers who helped to greatly
   improve this manuscript. We would also like to thank our colleagues at
   the Forestry Sciences Laboratory in Juneau, Alaska, Rick Edwards and
   Erik Norberg for field and laboratory assistance, and Frances Bites for
   assistance with Fig. 1. We would also like to thank the salmon research
   team from the University of Notre Dame for assistance in this research
   including Dom Chaloner, Scott Tiegs, Peter Levi, and Gary Lamberti. Jim
   Baichtal's consultation on paleo-landscape development was extremely
   helpful in developing the soil-geomorphic model, and his contributions
   are gratefully acknowledged. This project was partially supported by the
   USDA-CSREES National Research Initiative Competitive Grants Program
   (Ecosystem Science Program 2006-35101-16566).
NR 71
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U1 1
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-555X
EI 1872-695X
J9 GEOMORPHOLOGY
JI Geomorphology
PD MAR 15
PY 2011
VL 126
IS 3-4
SI SI
BP 377
EP 386
DI 10.1016/j.geomorph.2010.04.014
PG 10
WC Geography, Physical; Geosciences, Multidisciplinary
SC Physical Geography; Geology
GA 734AR
UT WOS:000288306100009
ER

PT J
AU Sedory, DM
   Crawford, JJ
   Topp, RF
AF Sedory, David M.
   Crawford, John J.
   Topp, Raymond F.
TI The Reliability of the Ball-Tipped Probe for Detecting Pedicle Screw
   Tract Violations Prior to Instrumenting the Thoracic and Lumbar Spine
SO SPINE
LA English
DT Article
DE pedicle screws; cadaver study; probing; reliability; pedicle violation;
   ball-tipped probe
ID COMPUTED-TOMOGRAPHY; RADIATION-EXPOSURE; IMAGE GUIDANCE; EVOKED EMG;
   PLACEMENT; ACCURACY; FLUOROSCOPY; INSERTION; FIXATION; SAFE
AB Study Design. Cadaveric.
   Objective: To determine the confidence with which surgeons should rely on a flexible ball-tipped probe to detect pedicle breeches in the thoracic and lumbar spine.
   Summary of Background Data. The reliability of a ball-tipped probe for detecting cortical violations of the pedicle tract has not been studied among fellowship-trained surgeons.
   Methods. A total of 134 pedicles were randomized to have pedicle screw tracts with one of six possible options: no violation, anterior, superior, inferior, medial, or lateral violations. Five fellowship-trained spine surgeons examined each pedicle, using a standard flexible ball-tipped probe on three nonsequential occasions. The percentage of correctly identified violations, sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the surgeons as a group and individually. The Cohen kappa coefficient was used to assess the accuracy of the observers and the interobserver and intraobserver agreement. Finally, we analyzed our results by spinal region to see whether this impacted the surgeons' ability to detect a pedicle violation.
   Results. The surgeons were able to correctly identify 81% of intact pedicles, 39% of superior, 68% of medial, 74% of lateral, 62% of anterior, and 50% of inferior violations. The sensitivity varied considerably by breech location and surgeon with a range of 18% to 85%. Positive predictive value for each breech location ranged from 12% to 20%. The specificity was 81% and negative predictive value 98% overall. The intraobserver reliability was moderate and interobserver reliability was low in this series. The ability to detect a pedicle violation was significantly better in the lower thoracic region (T6-T12) than in other areas of the spine.
   Conclusion. The standard ball-tipped probe was much less reliable than expected. This technique can be used to confirm an intact pedicle but has an unacceptably high false-positive rate and should be used with caution. Our study suggests that overconfidence in pedicle probing might be dangerous.
C1 [Sedory, David M.; Topp, Raymond F.] US Army Med Corps, Houston, TX USA.
   [Sedory, David M.; Topp, Raymond F.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Houston, TX USA.
   [Crawford, John J.] Knoxville Orthopaed Clin, Knoxville, TN USA.
RP Sedory, DM (reprint author), Winn Army Community Hosp, Dept Orthopaed, 1061 Harmon Ave, Ft Stewart, GA 31314 USA.
EM david.sedory@amedd.army.mil
NR 43
TC 3
Z9 3
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0362-2436
J9 SPINE
JI SPINE
PD MAR 15
PY 2011
VL 36
IS 6
BP E447
EP E453
DI 10.1097/BRS.0b013e3181dbfe40
PG 7
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 730BW
UT WOS:000288005700012
PM 21178848
ER

PT J
AU Meyers, RE
   Deacon, KS
   Shih, YH
AF Meyers, Ronald E.
   Deacon, Keith S.
   Shih, Yanhua
TI Turbulence-free ghost imaging
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID QUANTUM
AB Atmospheric turbulence is a serious problem for satellite and aircraft-to-ground based classical imaging. Taking advantage of the natural, nonfactorizable, point-to-point correlation of thermal light, this experiment demonstrated turbulence-free ghost imaging, which will be extremely useful for these applications. In addition, this observation suggests that the nontrivial intensity-intensity correlation of thermal light cannot be caused by the statistical correlation of intensity fluctuations. (C) 2011 American Institute of Physics.
C1 [Meyers, Ronald E.; Deacon, Keith S.] USA, Res Lab, Adelphi, MD 20783 USA.
   [Shih, Yanhua] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA.
RP Meyers, RE (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM ronald.meyers1@us.army.mil
FU ARL; Army Research Office Quantum Imaging MURI [W911NF-05-1-0197]; Air
   Force Office of Scientific Research [FA9550-09-1-0489]
FX R. Meyers and K. Deacon thank ARL for support. Y. H. Shih thanks Army
   Research Office Quantum Imaging MURI, W911NF-05-1-0197 and the Air Force
   Office of Scientific Research, FA9550-09-1-0489, for support.
NR 20
TC 72
Z9 74
U1 4
U2 37
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD MAR 14
PY 2011
VL 98
IS 11
AR 111115
DI 10.1063/1.3567931
PG 3
WC Physics, Applied
SC Physics
GA 737LC
UT WOS:000288569300088
ER

PT J
AU Zhang, J
   Fromzel, V
   Dubinskii, M
AF Zhang, Jun
   Fromzel, Viktor
   Dubinskii, Mark
TI Resonantly cladding-pumped Yb-free Er-doped LMA fiber laser with record
   high power and efficiency
SO OPTICS EXPRESS
LA English
DT Article
ID OUTPUT POWER
AB We report the results of our power scaling experiments with resonantly cladding-pumped Er-doped eye-safe large mode area (LMA) fiber laser. While using commercial off-the-shelf LMA fiber we achieved over 88 W of continuous-wave (CW) single transverse mode power at similar to 1590 nm while pumping at 1532.5 nm. Maximum observed optical-to-optical efficiency was 69%. This result presents, to the best of our knowledge, the highest power reported from resonantly-pumped Yb-free Er-doped LMA fiber laser, as well as the highest efficiency ever reported for any cladding-pumped Er-doped laser, either Yb-co-doped or Yb-free. (C)2011 Optical Society of America
C1 [Zhang, Jun; Fromzel, Viktor; Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA.
RP Zhang, J (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM mdubinskiy@arl.army.mil
NR 9
TC 38
Z9 39
U1 1
U2 16
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD MAR 14
PY 2011
VL 19
IS 6
BP 5574
EP 5578
DI 10.1364/OE.19.005574
PG 5
WC Optics
SC Optics
GA 741NV
UT WOS:000288871300096
PM 21445196
ER

PT J
AU Opsenica, I
   Burnett, JC
   Gussio, R
   Opsenica, D
   Todorovic, N
   Lanteri, CA
   Sciotti, RJ
   Gettayacamin, M
   Basilico, N
   Taramelli, D
   Nuss, JE
   Wanner, L
   Panchal, RG
   Solaja, BA
   Bavari, S
AF Opsenica, Igor
   Burnett, James C.
   Gussio, Rick
   Opsenica, Dejan
   Todorovic, Nina
   Lanteri, Charlotte A.
   Sciotti, Richard J.
   Gettayacamin, Montip
   Basilico, Nicoletta
   Taramelli, Donatella
   Nuss, Jonathan E.
   Wanner, Laura
   Panchal, Rekha G.
   Solaja, Bogdan A.
   Bavari, Sina
TI A Chemotype That Inhibits Three Unrelated Pathogenic Targets: The
   Botulinum Neurotoxin Serotype A Light Chain, P. falciparum Malaria, and
   the Ebola Filovirus
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID IN-VITRO; ANTIMALARIAL-DRUGS; PROTEOLYTIC ACTIVITY; VIRUS; CHLOROQUINE;
   TOXIN; 4-AMINOQUINOLINE; METALLOPROTEASE; PHARMACOPHORE; MECHANISMS
AB A 1,7-bis(alkylamino)diazachrysene-based small molecule was previously identified as an inhibitor of the botulinum neurotoxin serotype A light chain metalloprotease. Subsequently, a variety of derivatives of this chemotype were synthesized to develop structure activity relationships, and all are inhibitors of the BoNT/A LC. Three-dimensional analyses indicated that half of the originally discovered 1,7-DAAC structure superimposed well with 4-amino-7-chloroquinolinebased antimalarial agents. This observation led to the discovery that several of the 1,7-DAAC derivatives are potent in vitro inhibitors of Plasmodium falciparum and, in general, are more efficacious against CQ-resistant strains than against CQ-susceptible strains. In addition, by inhibiting beta-hematin formation, the most efficacious 1,7-DAAC-based antimalarials employ a mechanism of action analogous to that of 4,7-ACQ-based antimalarials and are well tolerated by normal cells. One candidate was also effective when administered orally in a rodent-based malaria model. Finally, the 1,7-DAAC-based derivatives were examined for Ebola filovirus inhibition in an assay employing Vero76 cells, and three provided promising antiviral activities and acceptably low toxicities.
C1 [Burnett, James C.] SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Natl Canc Inst Frederick, Frederick, MD 21702 USA.
   [Opsenica, Igor; Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11158, Serbia.
   [Gussio, Rick] Natl Canc Inst Frederick, Dev Therapeut Program, Frederick, MD 21702 USA.
   [Opsenica, Dejan; Todorovic, Nina] Inst Chem Technol & Met, Belgrade, Serbia.
   [Lanteri, Charlotte A.; Sciotti, Richard J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
   [Gettayacamin, Montip] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand.
   [Basilico, Nicoletta; Taramelli, Donatella] Univ Milan, Dipartimento Sanita Pubbl Microbiol Virol, I-20133 Milan, Italy.
   [Nuss, Jonathan E.; Wanner, Laura; Panchal, Rekha G.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Burnett, JC (reprint author), SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Natl Canc Inst Frederick, POB B, Frederick, MD 21702 USA.
EM burnettjames@mail.nih.gov; bsolaja@chem.bg.ac.rs;
   sina.bavari@us.army.mil
RI Sciotti, Richard/A-9069-2011; Opsenica, Igor/P-5308-2016; 
OI Opsenica, Igor/0000-0003-4942-4042; Solaja, Bogdan/0000-0002-9975-2725
FU NATO's Public Diplomacy Division [SfP983638]; Defense Threat Reduction
   Agency [3.10084_09_RD_B, Y3CM 100505]; Ministry of Science and
   Technological Development of Serbia [172008]; Serbian Academy of
   Sciences and Arts; National Cancer Institute, National Institutes of
   Health [HHSN261200800001E]
FX This research was supported by: (1) NATO's Public Diplomacy Division in
   the framework of "Science for Peace" project SfP983638, (2) Defense
   Threat Reduction Agency project 3.10084_09_RD_B (and also Agreement Y3CM
   100505 (MR-MC and NCI, National Institutes of Health), and (3) the
   Ministry of Science and Technological Development of Serbia (grant: no.
   172008) and the Serbian Academy of Sciences and Arts. The content of
   this publication does not necessarily reflect the views or policies of
   the U.S. Department of Health and Human Services, nor does the mention
   of trade names, commercial products, or organizations imply endorsement
   by the U.S. Government or the U.S. Army, The contents of this manuscript
   have been reviewed by the Walter Reed Army Institute of Research. There
   is no objection to its presentation or publication. The opinions or
   assertions contained herein are the private views of the authors and are
   not to be construed as official or as reflecting true views of the U.S.
   Department of the Army, Department of Defense, or National Institutes of
   Health. For J. C.B., in accordance with SAIC-Frederick, Inc. contractual
   requirements, the following statement must be included: this project has
   been funded in whole or in part with federal funds from the National
   Cancer Institute, National Institutes of Health, under contract no.
   HHSN261200800001E.
NR 74
TC 23
Z9 25
U1 0
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD MAR 10
PY 2011
VL 54
IS 5
BP 1157
EP 1169
DI 10.1021/jm100938u
PG 13
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 727WJ
UT WOS:000287833300004
PM 21265542
ER

PT J
AU Pollard, KA
   Blumstein, DT
AF Pollard, Kimberly A.
   Blumstein, Daniel T.
TI Social Group Size Predicts the Evolution of Individuality
SO CURRENT BIOLOGY
LA English
DT Article
ID SPERMOPHILUS-RICHARDSONII; ALARM CALLS; SQUIRRELS SPERMOPHILUS;
   POPULATION-DYNAMICS; KIN RECOGNITION; BEHAVIOR; SIGNALS; REPRODUCTION;
   INFORMATION; COMPLEXITY
AB Discriminating among individuals is a critical social behavior in humans and many other animals [1-3] and is often required for offspring and mate recognition, territorial or coalitional behaviors, signaler reliability assessment, and social hierarchies [4-9]. Being individually discriminated is more difficult in larger groups, and large group size may select for increased individuality-signature information-in social signals, to facilitate discrimination [4, 10-14]. Small-scale studies suggest that more social species have greater individuality in their social signals, such as contact calls [4,12,13]. However, this relationship has not been evaluated in a broader-scale evolutionary context or in social signals other than contact calls. It is not yet known whether social group size may be viewed as a general evolutionary driver of individuality. Here we show a strong positive evolutionary link between social group size in sciurid rodents and individuality in their social alarm calls. Social group size explained over 88% of the variation in vocal individuality in phylogenetic independent contrasts. Species living in larger groups, but not in more complex groups, had more signature information in their calls. Our results suggest that social group size may promote the evolution of individual signatures and that the sociality-individuality relationship may be a general phenomenon in nature.
C1 [Pollard, Kimberly A.; Blumstein, Daniel T.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA 90095 USA.
RP Pollard, KA (reprint author), USA, Human Res & Engn Directorate, Visual & Auditory Proc Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM kpollard@ucla.edu
RI Blumstein, Daniel/B-6199-2012; 
OI Blumstein, Daniel/0000-0001-5793-9244
FU American Philosophical Society; American Society of Mammalogists; Animal
   Behavior Society; Explorers Club; Mildred Mathias/UC Reserves; National
   Science Foundation; Sigma Xi; UCLA
FX We thank Suzanne Griffin for recordings of Olympic marmots and James
   Hare for recordings of Richardson's ground squirrels. We thank Olivier
   Munos for measurements of yellow-bellied marmot calls. For access to
   sites and animals, we thank Abby Benson, Dean Biggins, David Eads, John
   Hoogland, Jill Mateo, Dan Salkeld, Arapaho National Wildlife Refuge,
   Assiniboine Park Zoo, Olympic National Park, Rock Creek and the Sierra
   Nevada Aquatic Research Laboratory, Rocky Mountain Biological
   Laboratory, Sedgwick Reserve, Shortgrass Steppe Long-Term Ecological
   Research Station, UL Bend National Wildlife Refuge, and their personnel.
   We thank our laboratory and field assistants: Dalal Farsakh, Erik
   Tanaka, Nina Ben, Anh Thu Iran, Aya Satoh, Nina Mahoney, Yeshika Sharma,
   Asal Askarinam, John Mina, Aaron Nichols, Facundo Bermudez, Pontea
   Niaki, Christine Guenzi, Hao Li, Kathy Law, Rebecca Lee, Shabnum Patel,
   Liz Devietti, Rashad Mansour, Sahar Askarinam, Grace Li, and Cory
   Pender. We thank Peter Nonacs, Greg Grether, Joan Silk, Ben Rossi, and
   reviewers for comments on previous versions of this manuscript. K.A.P.
   was funded by the American Philosophical Society, the American Society
   of Mammalogists, the Animal Behavior Society, the Explorers Club,
   Mildred Mathias/UC Reserves, the National Science Foundation's Graduate
   Research Fellowship Program, Sigma Xi, a UCLA George Bartholomew
   Research Fellowship, a UCLA Holmes O. Miller Fellowship, and a UCLA
   Quality of Graduate Education Fellowship.
NR 47
TC 41
Z9 42
U1 0
U2 38
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0960-9822
J9 CURR BIOL
JI Curr. Biol.
PD MAR 8
PY 2011
VL 21
IS 5
BP 413
EP 417
DI 10.1016/j.cub.2011.01.051
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA 733XX
UT WOS:000288298900023
PM 21333537
ER

PT J
AU Hulten, EA
   Carbonaro, S
   Petrillo, SP
   Mitchell, JD
   Villines, TC
AF Hulten, Edward A.
   Carbonaro, Salvatore
   Petrillo, Sara P.
   Mitchell, Joshua D.
   Villines, Todd C.
TI Prognostic Value of Cardiac Computed Tomography Angiography A Systematic
   Review and Meta-Analysis
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE angiography; cardiac; computed tomography; meta-analysis; prognosis
ID CORONARY-ARTERY-DISEASE; EMERGENCY-DEPARTMENT PATIENTS; MULTIDETECTOR CT
   ANGIOGRAPHY; DIAGNOSTIC-TEST ACCURACY; ACUTE CHEST-PAIN; AMBULATORY
   PATIENTS; MAGNETIC-RESONANCE; HEART-DISEASE; ATHEROSCLEROSIS;
   PERFORMANCE
AB Objectives The purpose of this study was to systematically review and perform a meta-analysis of the ability of cardiac computed tomography angiography (CCTA) to predict future cardiovascular events and death.
   Background The diagnostic accuracy of CCTA is well reported. The prognostic value of CCTA has been described in several studies, but many were underpowered. Pooling outcomes increases the power to predict rare events.
   Methods We searched multiple databases for longitudinal studies of CCTA with at least 3 months follow-up of symptomatic patients with suspected coronary artery disease (CAD) reporting major adverse cardiovascular events (MACE), consisting of death, myocardial infarction (MI), and revascularization. Annualized event rates were pooled using a bivariate mixed-effects binomial regression model to calculate summary likelihood ratios and receiver-operating characteristic curves.
   Results Eighteen studies evaluated 9,592 patients with a median follow-up of 20 months. The pooled annualized event rate for obstructive (any vessel with > 50% luminal stenosis) versus normal CCTA was 8.8% versus 0.17% per year for MACE (p < 0.05) and 3.2% versus 0.15% for death or MI (p < 0.05). The pooled negative likelihood ratio for MACE after normal CCTA findings was 0.008 (95% confidence interval [CI]: 0.0004 to 0.17, p < 0.001), the positive likelihood ratio was 1.70 (95% CI: 1.42 to 2.02, p < 0.001), sensitivity was 0.99 (95% CI: 0.93 to 1.00, p < 0.001), and specificity was 0.41 (95% CI: 0.31 to 0.52, p < 0.001). Stratifying by no CAD, nonobstructive CAD (worst stenosis < 50%), or obstructive CAD, there were incrementally increasing adverse events.
   Conclusions Adverse cardiovascular events among patients with normal findings on CCTA are rare. There are incrementally increasing future MACE with increasing CAD by CCTA. (J Am Coll Cardiol 2011;57:1237-47) (C) 2011 by the American College of Cardiology Foundation
C1 [Hulten, Edward A.; Carbonaro, Salvatore; Villines, Todd C.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA.
   [Mitchell, Joshua D.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA.
   [Petrillo, Sara P.] Mid Atlantic Permanente Grp, Rockville, MD USA.
RP Hulten, EA (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM edward.hulten@us.army.mil
RI 刘, 李陆/H-8469-2015; 
OI Villines, Todd/0000-0003-2674-3702; Hulten, Edward/0000-0001-9281-0032
NR 67
TC 202
Z9 206
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 8
PY 2011
VL 57
IS 10
BP 1237
EP 1247
DI 10.1016/j.jacc.2010.10.011
PG 11
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA 729PI
UT WOS:000287962500011
PM 21145688
ER

PT J
AU Kumar, K
   Desai, V
   Cheng, L
   Khitrov, M
   Grover, D
   Satya, RV
   Yu, CG
   Zavaljevski, N
   Reifman, J
AF Kumar, Kamal
   Desai, Valmik
   Cheng, Li
   Khitrov, Maxim
   Grover, Deepak
   Satya, Ravi Vijaya
   Yu, Chenggang
   Zavaljevski, Nela
   Reifman, Jaques
TI AGeS: A Software System for Microbial Genome Sequence Annotation
SO PLOS ONE
LA English
DT Article
ID RAPID ANNOTATION; RNA GENES; PREDICTION; DATABASE; RESOURCE; INTERPRO;
   PROGRAM; SERVER; TOOL; DNA
AB Background: The annotation of genomes from next-generation sequencing platforms needs to be rapid, high-throughput, and fully integrated and automated. Although a few Web-based annotation services have recently become available, they may not be the best solution for researchers that need to annotate a large number of genomes, possibly including proprietary data, and store them locally for further analysis. To address this need, we developed a standalone software application, the Annotation of microbial Genome Sequences (AGeS) system, which incorporates publicly available and in-house-developed bioinformatics tools and databases, many of which are parallelized for high-throughput performance.
   Methodology: The AGeS system supports three main capabilities. The first is the storage of input contig sequences and the resulting annotation data in a central, customized database. The second is the annotation of microbial genomes using an integrated software pipeline, which first analyzes contigs from high-throughput sequencing by locating genomic regions that code for proteins, RNA, and other genomic elements through the Do-It-Yourself Annotation (DIYA) framework. The identified protein-coding regions are then functionally annotated using the in-house-developed Pipeline for Protein Annotation (PIPA). The third capability is the visualization of annotated sequences using GBrowse. To date, we have implemented these capabilities for bacterial genomes. AGeS was evaluated by comparing its genome annotations with those provided by three other methods. Our results indicate that the software tools integrated into AGeS provide annotations that are in general agreement with those provided by the compared methods. This is demonstrated by a > 94% overlap in the number of identified genes, a significant number of identical annotated features, and a > 90% agreement in enzyme function predictions.
C1 [Kumar, Kamal; Desai, Valmik; Cheng, Li; Khitrov, Maxim; Grover, Deepak; Satya, Ravi Vijaya; Yu, Chenggang; Zavaljevski, Nela; Reifman, Jaques] USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD USA.
RP Kumar, K (reprint author), USA, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD USA.
EM jaques.reifman@us.army.mil
OI Kumar, Kamal/0000-0002-9470-6682
FU United States Department of Defense High-Performance Computing
   Modernization Program (HPCMP) office, under the High-Performance
   Computing Software Applications Institutes (HSAI) Initiative
FX This work was partially sponsored by the United States Department of
   Defense High-Performance Computing Modernization Program (HPCMP) office,
   under the High-Performance Computing Software Applications Institutes
   (HSAI) Initiative. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. No additional external funding was received for this study.
NR 37
TC 13
Z9 13
U1 1
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 7
PY 2011
VL 6
IS 3
AR e17469
DI 10.1371/journal.pone.0017469
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 731IP
UT WOS:000288099800014
PM 21408217
ER

PT J
AU Burke, RL
   Vest, KG
   Eick, AA
   Sanchez, JL
   Johns, MC
   Pavlin, JA
   Jarman, RG
   Mothershead, JL
   Quintana, M
   Palys, T
   Cooper, MJ
   Guan, J
   Schnabel, D
   Waitumbi, J
   Wilma, A
   Daniels, C
   Brown, ML
   Tobias, S
   Kasper, MR
   Williams, M
   Tjaden, JA
   Oyofo, B
   Styles, T
   Blair, PJ
   Hawksworth, A
   Montgomery, JM
   Razuri, H
   Laguna-Torres, A
   Schoepp, RJ
   Norwood, DA
   MacIntosh, VH
   Gibbons, T
   Gray, GC
   Blazes, DL
   Russell, KL
AF Burke, Ronald L.
   Vest, Kelly G.
   Eick, Angelia A.
   Sanchez, Jose L.
   Johns, Matthew C.
   Pavlin, Julie A.
   Jarman, Richard G.
   Mothershead, Jerry L.
   Quintana, Miguel
   Palys, Thomas
   Cooper, Michael J.
   Guan, Jian
   Schnabel, David
   Waitumbi, John
   Wilma, Alisa
   Daniels, Candelaria
   Brown, Matthew L.
   Tobias, Steven
   Kasper, Matthew R.
   Williams, Maya
   Tjaden, Jeffrey A.
   Oyofo, Buhari
   Styles, Timothy
   Blair, Patrick J.
   Hawksworth, Anthony
   Montgomery, Joel M.
   Razuri, Hugo
   Laguna-Torres, Alberto
   Schoepp, Randal J.
   Norwood, David A.
   MacIntosh, Victor H.
   Gibbons, Thomas
   Gray, Gregory C.
   Blazes, David L.
   Russell, Kevin L.
CA AFHSC-GEIS Influenza Surveillance
TI Department of Defense influenza and other respiratory disease
   surveillance during the 2009 pandemic
SO BMC PUBLIC HEALTH
LA English
DT Review
ID PERSONNEL
AB The Armed Forces Health Surveillance Center's Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) supports and oversees surveillance for emerging infectious diseases, including respiratory diseases, of importance to the U. S. Department of Defense (DoD). AFHSC-GEIS accomplishes this mission by providing funding and oversight to a global network of partners for respiratory disease surveillance. This report details the system's surveillance activities during 2009, with a focus on efforts in responding to the novel H1N1 Influenza A (A/H1N1) pandemic and contributions to global public health. Active surveillance networks established by AFHSC-GEIS partners resulted in the initial detection of novel A/H1N1 influenza in the U. S. and several other countries, and viruses isolated from these activities were used as seed strains for the 2009 pandemic influenza vaccine. Partners also provided diagnostic laboratory training and capacity building to host nations to assist with the novel A/H1N1 pandemic global response, adapted a Food and Drug Administration-approved assay for use on a ruggedized polymerase chain reaction platform for diagnosing novel A/H1N1 in remote settings, and provided estimates of seasonal vaccine effectiveness against novel A/H1N1 illness. Regular reporting of the system's worldwide surveillance findings to the global public health community enabled leaders to make informed decisions on disease mitigation measures and controls for the 2009 A/H1N1 influenza pandemic. AFHSC-GEIS's support of a global network contributes to DoD's force health protection, while supporting global public health.
C1 [Burke, Ronald L.; Vest, Kelly G.; Eick, Angelia A.; Sanchez, Jose L.; Johns, Matthew C.; Blazes, David L.; Russell, Kevin L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
   [Pavlin, Julie A.; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Mothershead, Jerry L.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Ctr Disaster & Humanitarian Assistance Med, Bethesda, MD 20814 USA.
   [Quintana, Miguel] Publ Hlth Reg S, Ft Sam Houston, TX 78234 USA.
   [Palys, Thomas] Landstuhl Reg Med Ctr, Dept Pathol & Area Lab Serv, CMR 402, APO, AE 09180 USA.
   [Cooper, Michael J.] Publ Hlth Reg Europe, CMR 402, APO, AE 09180 USA.
   [Guan, Jian] Publ Hlth Reg Pacific, Unit 45006, APO, AE USA.
   [Schnabel, David; Waitumbi, John] Attent MRU, US Embassy, Nairobi 00621, Kenya.
   [Wilma, Alisa; Daniels, Candelaria] US Dept Def, Vet Food Anal & Diagnost Lab, Ft Sam Houston, TX 78234 USA.
   [Brown, Matthew L.] USAMEDDAC Korea, Microbiol Sect, Unit 15244, APO, AP 96205 USA.
   [Tobias, Steven; Kasper, Matthew R.; Williams, Maya] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia.
   [Tjaden, Jeffrey A.; Oyofo, Buhari] Naval Med Res Unit 3, Cairo 11517, Egypt.
   [Styles, Timothy] USN, Environm Prevent Med Unit 2, Norfolk, VA 23511 USA.
   [Blair, Patrick J.; Hawksworth, Anthony] USN, Hlth Res Ctr, San Diego, CA 92106 USA.
   [Montgomery, Joel M.; Razuri, Hugo; Laguna-Torres, Alberto] Ctr Med Naval CMST, Naval Med Res Ctr Detachment, Lima, Peru.
   [Schoepp, Randal J.; Norwood, David A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
   [MacIntosh, Victor H.; Gibbons, Thomas] USAF, Sch Aerosp Med, Brooks City Base, TX 78235 USA.
   [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL 32610 USA.
   Walter Reed Army Inst Res, Emerging Infect Dis Res Unit, Silver Spring, MD 20910 USA.
   Australian Army Malaria Inst, Enoggera, Qld 4051, Australia.
   Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
   USN, Portsmouth, VA 23708 USA.
   [AFHSC-GEIS Influenza Surveillance] Marine Corps Publ Hlth Ctr, Portsmouth, VA 23708 USA.
   Univ Buea, Lab Emerging Infect Dis, Buea, Cameroon.
   Global Viral Proc Initiat, San Francisco, CA 94104 USA.
RP Burke, RL (reprint author), USAF, Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Ronald.L.Burke@us.army.mil
RI Razuri, Hugo/C-1542-2013; Valle, Ruben/A-7512-2013; Chiang, Vincent,
   Ming-Hsien/D-4312-2016; Shanks, George Dennis/F-4056-2014
OI Razuri, Hugo/0000-0003-4571-5520; Chiang, Vincent,
   Ming-Hsien/0000-0002-2029-7863; Shanks, George
   Dennis/0000-0001-5763-8660
NR 19
TC 6
Z9 7
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S6
DI 10.1186/1471-2458-11-S2-S6
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900006
PM 21388566
ER

PT J
AU Fukuda, MM
   Klein, TA
   Kochel, T
   Quandelacy, TM
   Smith, BL
   Villinski, J
   Bethell, D
   Tyner, S
   Se, Y
   Lon, C
   Saunders, D
   Johnson, J
   Wagar, E
   Walsh, D
   Kasper, M
   Sanchez, JL
   Witt, CJ
   Cheng, Q
   Waters, N
   Shrestha, SK
   Pavlin, JA
   Lescano, AG
   Graf, PCF
   Richardson, JH
   Durand, S
   Rogers, WO
   Blazes, DL
   Russell, KL
AF Fukuda, Mark M.
   Klein, Terry A.
   Kochel, Tadeusz
   Quandelacy, Talia M.
   Smith, Bryan L.
   Villinski, Jeff
   Bethell, Delia
   Tyner, Stuart
   Se, Youry
   Lon, Chanthap
   Saunders, David
   Johnson, Jacob
   Wagar, Eric
   Walsh, Douglas
   Kasper, Matthew
   Sanchez, Jose L.
   Witt, Clara J.
   Cheng, Qin
   Waters, Norman
   Shrestha, Sanjaya K.
   Pavlin, Julie A.
   Lescano, Andres G.
   Graf, Paul C. F.
   Richardson, Jason H.
   Durand, Salomon
   Rogers, William O.
   Blazes, David L.
   Russell, Kevin L.
CA AFHSC-GEIS Malaria & Vector Borne
TI Malaria and other vector-borne infection surveillance in the US
   Department of Defense Armed Forces Health Surveillance Center-Global
   Emerging Infections Surveillance program: review of 2009 accomplishments
SO BMC PUBLIC HEALTH
LA English
DT Review
ID UNCOMPLICATED FALCIPARUM-MALARIA; PLASMODIUM-FALCIPARUM; RESISTANT
   MALARIA; HANTAVIRUS; CAMBODIA; DISEASES; DENGUE; VIRUS; KOREA;
   COMBINATIONS
AB Vector-borne infections (VBI) are defined as infectious diseases transmitted by the bite or mechanical transfer of arthropod vectors. They constitute a significant proportion of the global infectious disease burden. United States (U. S.) Department of Defense (DoD) personnel are especially vulnerable to VBIs due to occupational contact with arthropod vectors, immunological naivete to previously unencountered pathogens, and limited diagnostic and treatment options available in the austere and unstable environments sometimes associated with military operations. In addition to the risk uniquely encountered by military populations, other factors have driven the worldwide emergence of VBIs. Unprecedented levels of global travel, tourism and trade, and blurred lines of demarcation between zoonotic VBI reservoirs and human populations increase vector exposure. Urban growth in previously undeveloped regions and perturbations in global weather patterns also contribute to the rise of VBIs. The Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) and its partners at DoD overseas laboratories form a network to better characterize the nature, emergence and growth of VBIs globally. In 2009 the network tested 19,730 specimens from 25 sites for Plasmodium species and malaria drug resistance phenotypes and nearly another 10,000 samples to determine the etiologies of non-Plasmodium species VBIs from regions spanning from Oceania to Africa, South America, and northeast, south and Southeast Asia. This review describes recent VBI-related epidemiological studies conducted by AFHSC-GEIS partner laboratories within the OCONUS DoD laboratory network emphasizing their impact on human populations.
C1 [Fukuda, Mark M.; Quandelacy, Talia M.; Sanchez, Jose L.; Witt, Clara J.; Blazes, David L.; Russell, Kevin L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
   [Klein, Terry A.] Force Hlth Protect & Prevent Med, Med Brigade 65, Unit 15281, APO, AP 96205 USA.
   [Kochel, Tadeusz; Lescano, Andres G.; Graf, Paul C. F.; Durand, Salomon] Ctr Med Naval CMST, US Naval Med Res Ctr Detachment NMRCD, Lima, Peru.
   [Bethell, Delia; Tyner, Stuart; Se, Youry; Lon, Chanthap; Saunders, David; Shrestha, Sanjaya K.; Pavlin, Julie A.; Richardson, Jason H.] USA, Med Component Armed Forces Res Inst Med Sci, APO, AP 96546 USA.
   [Villinski, Jeff; Johnson, Jacob] US Embassy, US Army Med Res Unit Kenya, ATTN MRU, Nairobi 00621, Kenya.
   [Wagar, Eric; Walsh, Douglas] US Naval Med Res Unit, Cairo 11517, Egypt.
   [Kasper, Matthew; Rogers, William O.] US Embassy, US Navy Med Res Unit 2, Unit 8166, APO, AP 96546 USA.
   [Cheng, Qin; Waters, Norman] Australian Army Malaria Inst, Enoggera, Qld 4051, Australia.
   [AFHSC-GEIS Malaria & Vector Borne] USN, Med Res Ctr, Silver Spring, MD 20910 USA.
RP Fukuda, MM (reprint author), USAF, Hlth Surveillance Ctr, 2900 Linden Lane, Silver Spring, MD 20910 USA.
EM mark.m.fukuda@us.army.mil
RI Lescano, Andres/B-8479-2008; Richardson, Jason/A-9441-2011; Valle,
   Ruben/A-7512-2013; Shanks, George Dennis/F-4056-2014; 
OI Lescano, Andres/0000-0001-9779-633X; Graf, Paul/0000-0002-1094-7498;
   Shanks, George Dennis/0000-0001-5763-8660; durand,
   salomon/0000-0002-5923-8879
FU FIC NIH HHS [D43 TW007393, D43 TW007393-06]
NR 33
TC 7
Z9 7
U1 0
U2 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S9
DI 10.1186/1471-2458-11-S2-S9
PG 11
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900009
PM 21388569
ER

PT J
AU Johns, MC
   Burke, RL
   Vest, KG
   Fukuda, M
   Pavlin, JA
   Shrestha, SK
   Schnabel, DC
   Tobias, S
   Tjaden, JA
   Montgomery, JM
   Faix, DJ
   Duffy, MR
   Cooper, MJ
   Sanchez, JL
   Blazes, DL
AF Johns, Matthew C.
   Burke, Ronald L.
   Vest, Kelly G.
   Fukuda, Mark
   Pavlin, Julie A.
   Shrestha, Sanjaya K.
   Schnabel, David C.
   Tobias, Steven
   Tjaden, Jeffrey A.
   Montgomery, Joel M.
   Faix, Dennis J.
   Duffy, Mark R.
   Cooper, Michael J.
   Sanchez, Jose L.
   Blazes, David L.
CA AFHSC-GEIS Outbreak Response
TI A growing global network's role in outbreak response: AFHSC-GEIS
   2008-2009
SO BMC PUBLIC HEALTH
LA English
DT Review
ID COUNTRIES
AB A cornerstone of effective disease surveillance programs comprises the early identification of infectious threats and the subsequent rapid response to prevent further spread. Effectively identifying, tracking and responding to these threats is often difficult and requires international cooperation due to the rapidity with which diseases cross national borders and spread throughout the global community as a result of travel and migration by humans and animals. From Oct. 1, 2008 to Sept. 30, 2009, the United States Department of Defense's (DoD) Armed Forces Health Surveillance Center Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) identified 76 outbreaks in 53 countries. Emerging infectious disease outbreaks were identified by the global network and included a wide spectrum of support activities in collaboration with host country partners, several of which were in direct support of the World Health Organization's (WHO) International Health Regulations (IHR) (2005). The network also supported military forces around the world affected by the novel influenza A/H1N1 pandemic of 2009. With IHR (2005) as the guiding framework for action, the AFHSC-GEIS network of international partners and overseas research laboratories continues to develop into a far-reaching system for identifying, analyzing and responding to emerging disease threats.
C1 [Johns, Matthew C.; Burke, Ronald L.; Vest, Kelly G.; Fukuda, Mark; Sanchez, Jose L.; Blazes, David L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20904 USA.
   [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Shrestha, Sanjaya K.] US Embassy, Walter Reed AFRIMS Res Unit Nepal, Kathmandu, Nepal.
   [Schnabel, David C.] US Embassy, Attn MRU, Nairobi 00621, Kenya.
   [Tobias, Steven] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia.
   [Tjaden, Jeffrey A.] Naval Med Res Unit 3, Cairo, Egypt.
   [Montgomery, Joel M.] Ctr Med Naval CMST, Naval Med Res Ctr Detachment Peru, Lima, Peru.
   [Faix, Dennis J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA.
   [Duffy, Mark R.] USAF, Sch Aerosp Med, Epidemiol Consult Serv, Brooks City Base, TX 78235 USA.
   [Cooper, Michael J.; AFHSC-GEIS Outbreak Response] US Publ Hlth Command Provis Publ Hlth Reg Europe, Landstuhl, Germany.
RP Johns, MC (reprint author), USAF, Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20904 USA.
EM Matthew.C.Johns@us.army.mil
RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014
OI Bulimo, Wallace/0000-0001-8475-0586
NR 21
TC 2
Z9 3
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S3
DI 10.1186/1471-2458-11-S2-S3
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900003
PM 21388563
ER

PT J
AU Meyer, WG
   Pavlin, JA
   Hospenthal, D
   Murray, CK
   Jerke, K
   Hawksworth, A
   Metzgar, D
   Myers, T
   Walsh, D
   Wu, M
   Ergas, R
   Chukwuma, U
   Tobias, S
   Klena, J
   Nakhla, I
   Talaat, M
   Maves, R
   Ellis, M
   Wortmann, G
   Blazes, DL
   Lindler, L
AF Meyer, William G.
   Pavlin, Julie A.
   Hospenthal, Duane
   Murray, Clinton K.
   Jerke, Kurt
   Hawksworth, Anthony
   Metzgar, David
   Myers, Todd
   Walsh, Douglas
   Wu, Max
   Ergas, Rosa
   Chukwuma, Uzo
   Tobias, Steven
   Klena, John
   Nakhla, Isabelle
   Talaat, Maha
   Maves, Ryan
   Ellis, Michael
   Wortmann, Glenn
   Blazes, David L.
   Lindler, Luther
TI Antimicrobial resistance surveillance in the AFHSC-GEIS network
SO BMC PUBLIC HEALTH
LA English
DT Review
ID SUSCEPTIBILITIES; LEPTOSPIRA
AB International infectious disease surveillance has been conducted by the United States (U. S.) Department of Defense (DoD) for many years and has been consolidated within the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) since 1998. This includes activities that monitor the presence of antimicrobial resistance among pathogens. AFHSC-GEIS partners work within DoD military treatment facilities and collaborate with host-nation civilian and military clinics, hospitals and university systems. The goals of these activities are to foster military force health protection and medical diplomacy. Surveillance activities include both community-acquired and health care-associated infections and have promoted the development of surveillance networks, centers of excellence and referral laboratories. Information technology applications have been utilized increasingly to aid in DoD-wide global surveillance for diseases significant to force health protection and global public health. This section documents the accomplishments and activities of the network through AFHSC-GEIS partners in 2009.
C1 [Meyer, William G.; Blazes, David L.; Lindler, Luther] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20904 USA.
   [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Hospenthal, Duane] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
   [Jerke, Kurt] Landstuhl Reg Med Ctr, Dept Immunol, CMR 402, APO, AE 09180 USA.
   [Hawksworth, Anthony; Metzgar, David] USN, Hlth Res Ctr, San Diego, CA 92106 USA.
   [Myers, Todd] Natl Naval Med Ctr, Bethesda, MD 20889 USA.
   [Walsh, Douglas; Wu, Max] US Embassy, US Army Med Res Unit Kenya, ATTN MRU, Nairobi 00621, Kenya.
   [Ergas, Rosa; Chukwuma, Uzo] USN, Portsmouth, VA 23708 USA.
   [Ergas, Rosa; Chukwuma, Uzo] Marine Corps Publ Hlth Ctr, Portsmouth, VA 23708 USA.
   [Tobias, Steven] Kompleks Pergudangan DEPKES RI, US Naval Med Res Unit 2, Jakarta 10560, Indonesia.
   [Klena, John; Nakhla, Isabelle; Talaat, Maha] US Naval Med Res Unit 3, Cairo 11517, Egypt.
   [Maves, Ryan] Ctr Med Naval CMST, US Naval Med Res Ctr Detachment, Lima, Peru.
   [Ellis, Michael; Wortmann, Glenn] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Meyer, WG (reprint author), USAF, Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20904 USA.
EM william.meyer6@us.army.mil
RI Valle, Ruben/A-7512-2013
NR 21
TC 6
Z9 7
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S8
DI 10.1186/1471-2458-11-S2-S8
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900008
PM 21388568
ER

PT J
AU Otto, JL
   Baliga, P
   Sanchez, JL
   Johns, MC
   Gray, GC
   Grieco, J
   Lescano, AG
   Mothershead, JL
   Wagar, EJ
   Blazes, DL
AF Otto, Jean L.
   Baliga, Priya
   Sanchez, Jose L.
   Johns, Matthew C.
   Gray, Gregory C.
   Grieco, John
   Lescano, Andres G.
   Mothershead, Jerry L.
   Wagar, Eric J.
   Blazes, David L.
CA AFHSC-GEIS Training Writing Grp
TI Training initiatives within the AFHSC-Global Emerging Infections
   Surveillance and Response System: support for IHR (2005)
SO BMC PUBLIC HEALTH
LA English
DT Review
AB Training is a key component of building capacity for public health surveillance and response, but has often been difficult to quantify. During fiscal 2009, the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) supported 18 partner organizations in conducting 123 training initiatives in 40 countries for 3,130 U.S. military, civilian and host-country personnel. The training assisted with supporting compliance with International Health Regulations, IHR (2005). Training activities in pandemic preparedness, outbreak investigation and response, emerging infectious disease (EID) surveillance and pathogen diagnostic techniques were expanded significantly. By engaging local health and other government officials and civilian institutions, the U.S. military's role as a key stakeholder in global public health has been strengthened and has contributed to EID-related surveillance, research and capacity-building initiatives specified elsewhere in this issue. Public health and emerging infections surveillance training accomplished by AFHSC-GEIS and its Department of Defense (DoD) partners during fiscal 2009 will be tabulated and described.
C1 [Otto, Jean L.; Baliga, Priya; Sanchez, Jose L.; Johns, Matthew C.; Blazes, David L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20904 USA.
   [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL 32610 USA.
   [Lescano, Andres G.] Ctr Med Naval CMST, Naval Med Res Ctr Detachment, Lima, Peru.
   [Mothershead, Jerry L.] Uniformed Serv Univ Hlth Sci, Ctr Disaster & Humanitarian Assistance Med, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
   [Wagar, Eric J.] Attent MRU, US Embassy, Nairobi 00621, Kenya.
   Makerere Univ, Walter Reed Project, Influenza Res Programme, Kampala, Uganda.
   Univ Iowa, Ctr Emerging Infect Dis, Coralville, IA 52241 USA.
   USN, Hlth Res Ctr, San Diego, CA 92106 USA.
   Med Brigade USAMEDDAC Korea, Unit 15281, APO, AP 96205 USA.
   Publ Hlth Reg Europe, CMR 402, APO, AE 09180 USA.
   USN, Environm Prevent Med Unit 2, Norfolk, VA 23511 USA.
   Pacific AF, Hickam AFB, HI 96853 USA.
   USAF, Sch Aerosp Med, Epidemiol Consult Serv, Brooks City Base, TX 78235 USA.
   Naval Med Res Unit 3, Cairo 11517, Egypt.
   Univ Buea, Dept Biochem & Microbiol, Fac Sci, Buea, South Western, Cameroon.
   Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   Publ Hlth Reg S, Ft Sam Houston, TX 78234 USA.
   [AFHSC-GEIS Training Writing Grp] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia.
RP Baliga, P (reprint author), USAF, Hlth Surveillance Ctr, 11800 Tech Rd, Silver Spring, MD 20904 USA.
EM priya.baliga@us.army.mil
RI Lescano, Andres/B-8479-2008; Valle, Ruben/A-7512-2013; Bulimo,
   Wallace/B-1982-2014
OI Lescano, Andres/0000-0001-9779-633X; Bulimo, Wallace/0000-0001-8475-0586
FU FIC NIH HHS [D43 TW007393, D43 TW007393-06]
NR 13
TC 0
Z9 0
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S5
DI 10.1186/1471-2458-11-S2-S5
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900005
PM 21388565
ER

PT J
AU Sanchez, JL
   Johns, MC
   Burke, RL
   Vest, KG
   Fukuda, MM
   Yoon, IK
   Lon, C
   Quintana, M
   Schnabel, DC
   Pimentel, G
   Mansour, M
   Tobias, S
   Montgomery, JM
   Gray, GC
   Saylors, K
   Ndip, LM
   Lewis, S
   Blair, PJ
   Sjoberg, PA
   Kuschner, RA
   Russell, KL
   Blazes, DL
AF Sanchez, Jose L.
   Johns, Matthew C.
   Burke, Ronald L.
   Vest, Kelly G.
   Fukuda, Mark M.
   Yoon, In-Kyu
   Lon, Chanthap
   Quintana, Miguel
   Schnabel, David C.
   Pimentel, Guillermo
   Mansour, Moustafa
   Tobias, Steven
   Montgomery, Joel M.
   Gray, Gregory C.
   Saylors, Karen
   Ndip, Lucy M.
   Lewis, Sheri
   Blair, Patrick J.
   Sjoberg, Paul A.
   Kuschner, Robert A.
   Russell, Kevin L.
   Blazes, David L.
CA AFHSC-GEIS Capacity Bldg Writing
TI Capacity-building efforts by the AFHSC-GEIS program
SO BMC PUBLIC HEALTH
LA English
DT Review
ID HEALTH; SYSTEM
AB Capacity-building initiatives related to public health are defined as developing laboratory infrastructure, strengthening host-country disease surveillance initiatives, transferring technical expertise and training personnel. These initiatives represented a major piece of the Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System (AFHSC-GEIS) contributions to worldwide emerging infectious disease (EID) surveillance and response. Capacity-building initiatives were undertaken with over 80 local and regional Ministries of Health, Agriculture and Defense, as well as other government entities and institutions worldwide. The efforts supported at least 52 national influenza centers and other country-specific influenza, regional and U.S.-based EID reference laboratories (44 civilian, eight military) in 46 countries worldwide. Equally important, reference testing, laboratory infrastructure and equipment support was provided to over 500 field sites in 74 countries worldwide from October 2008 to September 2009. These activities allowed countries to better meet the milestones of implementation of the 2005 International Health Regulations and complemented many initiatives undertaken by other U.S. government agencies, such as the U.S. Department of Health and Human Services, the U.S. Agency for International Development and the U.S. Department of State.
C1 [Sanchez, Jose L.; Johns, Matthew C.; Burke, Ronald L.; Vest, Kelly G.; Fukuda, Mark M.; Russell, Kevin L.; Blazes, David L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
   [Fukuda, Mark M.; Yoon, In-Kyu; Lon, Chanthap] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Quintana, Miguel] USA, Publ Hlth Command Reg S, Ft Sam Houston, TX 78234 USA.
   [Schnabel, David C.] US Embassy, US Army Med Res Unit Kenya, Attn MRU, Nairobi 00621, Kenya.
   [Pimentel, Guillermo; Mansour, Moustafa] Naval Med Res Unit 3, Cairo 11517, Egypt.
   [Tobias, Steven] Kompleks Pergudangan DEPKES RI, Naval Med Res Unit 2, Jakarta 10560, Indonesia.
   [Montgomery, Joel M.] Ctr Med Naval CMST, Naval Med Res Ctr Detachment Peru, Lima, Peru.
   [Gray, Gregory C.] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Environm & Global Hlth, Gainesville, FL 32610 USA.
   [Saylors, Karen] Global Viral Forecasting Initiat, San Francisco, CA 94104 USA.
   [Ndip, Lucy M.] Univ Buea, Dept Biochem & Microbiol, Fac Sci, Buea, South Western, Cameroon.
   [Lewis, Sheri] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
   [Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92106 USA.
   [Sjoberg, Paul A.] USAF, Sch Aerosp Med, Publ Hlth & Prevent Med Dept, Brooks City Base, TX 78235 USA.
   [Kuschner, Robert A.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
   Kenya Govt Med Res Ctr, Nairobi 00200, Kenya.
   Landstuhl Reg Med Ctr, CMR 402, APO, AE 09180 USA.
   Makerere Univ, Walter Reed Project, Kampala, Uganda.
   Makerere Univ, Fac Vet Med & Med, Kampala, Uganda.
   USN, Environm & Prevent Med Unit, Norfolk, VA 23511 USA.
   PharmAccess Fdn, Dar Es Salaam, Tanzania.
   Tanzania Peoples Def Forces, Def Forces Headquarters Med Serv, Dar Es Salaam, Tanzania.
   USA, Med Dept Act & Med Brigade 65, Unit 15281, APO, AP 96205 USA.
   USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
   USA, Publ Hlth Command Reg Europe, APO, AE 09180 USA.
   [AFHSC-GEIS Capacity Bldg Writing] USA, Publ Hlth Command Reg Pacific, Unit 45006, APO, AP 96343 USA.
RP Sanchez, JL (reprint author), USAF, Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Toti.Sanchez@us.army.mil
RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014; 
OI Bulimo, Wallace/0000-0001-8475-0586; Pimentel,
   Guillermo/0000-0003-2464-1526
NR 19
TC 6
Z9 7
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S4
DI 10.1186/1471-2458-11-S2-S4
PG 9
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900004
PM 21388564
ER

PT J
AU Witt, CJ
   Richards, AL
   Masuoka, PM
   Foley, DH
   Buczak, AL
   Musila, LA
   Richardson, JH
   Colacicco-Mayhugh, MG
   Rueda, LM
   Klein, TA
   Anyamba, A
   Small, J
   Pavlin, JA
   Fukuda, MM
   Gaydos, J
   Russell, KL
AF Witt, Clara J.
   Richards, Allen L.
   Masuoka, Penny M.
   Foley, Desmond H.
   Buczak, Anna L.
   Musila, Lillian A.
   Richardson, Jason H.
   Colacicco-Mayhugh, Michelle G.
   Rueda, Leopoldo M.
   Klein, Terry A.
   Anyamba, Assaf
   Small, Jennifer
   Pavlin, Julie A.
   Fukuda, Mark M.
   Gaydos, Joel
   Russell, Kevin L.
CA AFHSC-GEIS Predictive Surveillance
TI The AFHSC-Division of GEIS Operations Predictive Surveillance Program: a
   multidisciplinary approach for the early detection and response to
   disease outbreaks
SO BMC PUBLIC HEALTH
LA English
DT Review
ID REPUBLIC-OF-KOREA; RIFT-VALLEY; CUTANEOUS LEISHMANIASIS; BARINGO
   DISTRICT; UNITED-STATES; GEOGRAPHIC DISTRIBUTIONS; VISCERAL
   LEISHMANIASIS; CLIMATE-CHANGE; KENYA; HANTAVIRUS
AB The Armed Forces Health Surveillance Center, Division of Global Emerging Infections Surveillance and Response System Operations (AFHSC-GEIS) initiated a coordinated, multidisciplinary program to link data sets and information derived from eco-climatic remote sensing activities, ecologic niche modeling, arthropod vector, animal disease-host/reservoir, and human disease surveillance for febrile illnesses, into a predictive surveillance program that generates advisories and alerts on emerging infectious disease outbreaks. The program's ultimate goal is pro-active public health practice through pre-event preparedness, prevention and control, and response decision-making and prioritization. This multidisciplinary program is rooted in over 10 years experience in predictive surveillance for Rift Valley fever outbreaks in Eastern Africa. The AFHSC-GEIS Rift Valley fever project is based on the identification and use of disease-emergence critical detection points as reliable signals for increased outbreak risk. The AFHSC-GEIS predictive surveillance program has formalized the Rift Valley fever project into a structured template for extending predictive surveillance capability to other Department of Defense (DoD)-priority vector-and water-borne, and zoonotic diseases and geographic areas. These include leishmaniasis, malaria, and Crimea-Congo and other viral hemorrhagic fevers in Central Asia and Africa, dengue fever in Asia and the Americas, Japanese encephalitis (JE) and chikungunya fever in Asia, and rickettsial and other tick-borne infections in the U. S., Africa and Asia.
C1 [Witt, Clara J.; Fukuda, Mark M.; Gaydos, Joel; Russell, Kevin L.] USAF, Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
   [Richards, Allen L.] USN, Med Res Ctr, Dept Rickettsial Dis Res Program, Silver Spring, MD 20910 USA.
   [Richards, Allen L.; Masuoka, Penny M.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
   [Foley, Desmond H.; Colacicco-Mayhugh, Michelle G.; Rueda, Leopoldo M.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, Silver Spring, MD 20910 USA.
   [Buczak, Anna L.] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
   [Musila, Lillian A.] Kenya Govt Med Res Ctr, Ctr Virus Res, Nairobi, Kenya.
   [Musila, Lillian A.] USA, Med Res Unit Kenya, Nairobi Unit 64109, APO, AE 09831 USA.
   [Richardson, Jason H.; Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Klein, Terry A.] Force Hlth Protect & Prevent Med, Med Brigade 65, Unit 15281, APO, AP 96205 USA.
   [Anyamba, Assaf; Small, Jennifer] NASA, Goddard Space Flight Ctr, Biospher Sci Branch, GIMMS Grp, Greenbelt, MD 20771 USA.
   USN, Portsmouth, VA 23708 USA.
   Marine Corps Public Hlth Ctr, Portsmouth, VA 23708 USA.
   USDA, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA.
   Naval Med Res Unit 3, Cairo 11517, Egypt.
   USA, Med Res Unit Kenya, Dept Entomol & Vector Borne Dis, Kisumu Unit 8900, APO, AE 09831 USA.
   [AFHSC-GEIS Predictive Surveillance] Komplek P2M PLP LITBANGKES JI, Naval Med Res Unit 2, Jakarta 10560, Indonesia.
   US Naval Med Res Ctr Detachment, Ctr Med Naval CEMENA, Lima, Peru.
   Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA.
RP Witt, CJ (reprint author), USAF, Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM clara.witt@us.army.mil
RI Richardson, Jason/A-9441-2011; Valle, Ruben/A-7512-2013; 
OI Foley, Desmond/0000-0001-7525-4601
NR 48
TC 7
Z9 7
U1 3
U2 28
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 4
PY 2011
VL 11
SU 2
AR S10
DI 10.1186/1471-2458-11-S2-S10
PG 16
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA 759WT
UT WOS:000290279900010
PM 21388561
ER

PT J
AU Danielson, KT
   O'Daniel, JL
AF Danielson, Kent T.
   O'Daniel, James L.
TI Reliable second-order hexahedral elements for explicit methods in
   nonlinear solid dynamics
SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
LA English
DT Article
DE nonlinear solid dynamics; second-order finite elements; explicit time
   integration; mass matrix diagonalization; mass lumping
ID FINITE-ELEMENT; HOURGLASS CONTROL; MICROPLANE MODEL; STRAIN; CONCRETE;
   STRESS; ELASTICITY; QUADRATURE
AB Second-order hexahedral elements are common in static and implicit dynamic finite element codes for nonlinear solid mechanics. Although probably not as popular as first-order elements, they can perform better in many circumstances, particularly for modeling curved shapes and bending without artificial hourglass control or incompatible modes. Nevertheless, second-order brick elements are not contained in typical explicit solid dynamic programs and unsuccessful attempts to develop reliable ones have been reported. In this paper, 27-node formulations, one for compressible and one for nearly incompressible materials, are presented and evaluated using non-uniform row summation mass lumping in a wide range of nonlinear example problems. The performance is assessed in standard benchmark problems and in large practical applications using various hyperelastic and inelastic material models and involving very large strains/deformations, severe distortions, and contact-impact. Comparisons are also made with several first-order elements and other second-order hexahedral formulations. The offered elements are the only second-order ones that performed satisfactorily in all examples, and performed generally at least as well as mass lumped first-order bricks. It is shown that the row summation lumping is vital for robust performance and selection of Lagrange over serendipity elements and high-order quadrature rules are more crucial with explicit than with static/implicit methods. Whereas the reliable performance is frequently attained at significant computational expense compared with some first-order brick types, these elements are shown to be computationally competitive in flexure and with other first-order elements. These second-order elements are shown to be viable for large practical applications, especially using today's parallel computers. Published in 2010 by John Wiley & Sons, Ltd.
C1 [Danielson, Kent T.] USA, Impact & Explos Effects Branch, Attn CEERD GM 1, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [O'Daniel, James L.] USA, Struct Mech Branch, Attn CEERD GS M, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Danielson, KT (reprint author), USA, Impact & Explos Effects Branch, Attn CEERD GM 1, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Kent.T.Danielson@us.army.mil
FU DOD at the ERDC DOD Supercomputing Resource Center (DSRC)
FX The permission to publish was granted by the Director, Geotechnical and
   Structures Laboratory. The work was supported in part by grants of
   computer time from the DOD High Performance Computing Modernization
   Program at the ERDC DOD Supercomputing Resource Center (DSRC).
NR 52
TC 4
Z9 4
U1 2
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0029-5981
J9 INT J NUMER METH ENG
JI Int. J. Numer. Methods Eng.
PD MAR 4
PY 2011
VL 85
IS 9
BP 1073
EP 1102
DI 10.1002/nme.3003
PG 30
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
   Applications
SC Engineering; Mathematics
GA 718VR
UT WOS:000287155100001
ER

PT J
AU Nie, X
   Cheng, JI
   Chen, WNW
   Weerasooriya, T
AF Nie, Xu
   Cheng, Jen-I
   Chen, Weinong W.
   Weerasooriya, Tusit
TI Dynamic Tensile Response of Porcine Muscle
SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
LA English
DT Article
DE biological tissue; porcine muscle; dynamic behavior; impact
   biomechanics; split Hopkinson tension bar; stress-strain; strain rate
ID SPLIT HOPKINSON BAR; SOFT MATERIALS; TISSUE; STRAIN; BIOMECHANICS;
   COMPRESSION; FIBERS; THORAX; RATES; RAW
AB The stress-strain response of a porcine muscle along and perpendicular to the muscle fiber direction was characterized over a wide range of strain rates under uniaxial tension. A modified Kolsky tension bar was used to conduct the experiments at high strain rates. Tubular specimen geometry was used to achieve uniform loading within the specimen and to minimize lateral inertia effect. Loading pulse was controlled to facilitate constant strain rates and dynamic stress equilibrium. Quasi-static experiments were also performed to explore the rate effects over a wider range of strain rates. The results show that the nonlinear tensile stress-strain responses in both directions along and perpendicular to the fibers are highly sensitive to strain rates. Compared with high-rate compression response, the strain rate sensitivity in the tensile test is less dependent on the fiber orientation to the loading direction. [DOI: 10.1115/1.4002580]
C1 [Nie, Xu; Chen, Weinong W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
   [Cheng, Jen-I; Chen, Weinong W.] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA.
   [Weerasooriya, Tusit] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Nie, X (reprint author), Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
EM xnie@purdue.edu
FU U.S. Army Research Laboratory (ARL) through Purdue University
FX This research was supported by U.S. Army Research Laboratory (ARL)
   through a collaborative research agreement with Purdue University.
NR 29
TC 7
Z9 7
U1 2
U2 18
PU ASME-AMER SOC MECHANICAL ENG
PI NEW YORK
PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0021-8936
J9 J APPL MECH-T ASME
JI J. Appl. Mech.-Trans. ASME
PD MAR
PY 2011
VL 78
IS 2
AR 021009
DI 10.1115/1.4002580
PG 5
WC Mechanics
SC Mechanics
GA 866LD
UT WOS:000298381300009
ER

PT J
AU Fuller, T
   Thomassen, HA
   Mulembakani, PM
   Johnston, SC
   Lloyd-Smith, JO
   Kisalu, NK
   Lutete, TK
   Blumberg, S
   Fair, JN
   Wolfe, ND
   Shongo, RL
   Formenty, P
   Meyer, H
   Wright, LL
   Muyembe, JJ
   Buermann, W
   Saatchi, SS
   Okitolonda, E
   Hensley, L
   Smith, TB
   Rimoin, AW
AF Fuller, Trevon
   Thomassen, Henri A.
   Mulembakani, Prime M.
   Johnston, Sara C.
   Lloyd-Smith, James O.
   Kisalu, Neville K.
   Lutete, Timothee K.
   Blumberg, Seth
   Fair, Joseph N.
   Wolfe, Nathan D.
   Shongo, Robert L.
   Formenty, Pierre
   Meyer, Hermann
   Wright, Linda L.
   Muyembe, Jean-Jacques
   Buermann, Wolfgang
   Saatchi, Sassan S.
   Okitolonda, Emile
   Hensley, Lisa
   Smith, Thomas B.
   Rimoin, Anne W.
TI Using Remote Sensing to Map the Risk of Human Monkeypox Virus in the
   Congo Basin
SO ECOHEALTH
LA English
DT Article
DE monkeypox; orthopoxvirus; smallpox vaccination; epidemiology; active
   surveillance; human transmission
ID ECOLOGICAL NICHE; SPECIES DISTRIBUTIONS; DISTRIBUTION MODELS;
   TRANSMISSION; POPULATION; AFRICA; MAXENT; ZAIRE
AB Although the incidence of human monkeypox has greatly increased in Central Africa over the last decade, resources for surveillance remain extremely limited. We conducted a geospatial analysis using existing data to better inform future surveillance efforts. Using active surveillance data collected between 2005 and 2007, we identified locations in Sankuru district, Democratic Republic of Congo (DRC) where there have been one or more cases of human monkeypox. To assess what taxa constitute the main reservoirs of monkeypox, we tested whether human cases were associated with (i) rope squirrels (Funisciurus sp.), which were implicated in monkeypox outbreaks elsewhere in the DRC in the 1980s, or (ii) terrestrial rodents in the genera Cricetomys and Graphiurus, which are believed to be monkeypox reservoirs in West Africa. Results suggest that the best predictors of human monkeypox cases are proximity to dense forests and associated habitat preferred by rope squirrels. The risk of contracting monkeypox is significantly greater near sites predicted to be habitable for squirrels (OR = 1.32; 95% CI 1.08-1.63). We recommend that semi-deciduous rainforests with oil-palm, the rope squirrel's main food source, be prioritized for monitoring.
C1 [Lloyd-Smith, James O.; Blumberg, Seth; Rimoin, Anne W.] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
   [Fuller, Trevon; Thomassen, Henri A.; Buermann, Wolfgang; Saatchi, Sassan S.; Smith, Thomas B.] Univ Calif Los Angeles, Inst Environm, Ctr Trop Res, Los Angeles, CA 90095 USA.
   [Mulembakani, Prime M.; Lutete, Timothee K.; Okitolonda, Emile] Kinshasa Sch Publ Hlth, Kinshasa, Zaire.
   [Johnston, Sara C.; Hensley, Lisa] USA, Med Res Inst Infect Dis, Frederick, MD USA.
   [Lloyd-Smith, James O.; Blumberg, Seth; Smith, Thomas B.] Univ Calif Los Angeles, Dept Ecol & Evolutionary Biol, Los Angeles, CA USA.
   [Kisalu, Neville K.] Univ Calif Los Angeles, Dept Microbiol, Los Angeles, CA 90024 USA.
   [Fair, Joseph N.; Wolfe, Nathan D.] Global Viral Forecasting Initiat, San Francisco, CA USA.
   [Shongo, Robert L.] Minist Hlth, Kinshasa, Zaire.
   [Formenty, Pierre] WHO, Dept Global Alert & Response, CH-1211 Geneva, Switzerland.
   [Meyer, Hermann] Bundeswehr Inst Microbiol, Munich, Germany.
   [Wright, Linda L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
   [Muyembe, Jean-Jacques] Natl Inst Biomed Res, Kinshasa, Zaire.
   [Buermann, Wolfgang] Univ Calif Los Angeles, Dept Atmospher & Ocean Sci, Los Angeles, CA USA.
   [Saatchi, Sassan S.] CALTECH, Jet Prop Lab, Radar Sci & Engn Sect, Radar Sci Tech Grp, Pasadena, CA USA.
   [Rimoin, Anne W.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
RP Rimoin, AW (reprint author), NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA.
EM arimoin@ucla.edu
RI Lloyd-Smith, James/K-4080-2012; Valle, Ruben/A-7512-2013
OI Lloyd-Smith, James/0000-0001-7941-502X; 
FU Faucett Family Foundation; National Institutes of Health, National
   Institute of Child Health and Human Development, Bethesda, MD, USA;
   National Science Foundation-National Institutes of Health [EF-0430146];
   RAPIDD of the Science and Technology Directorate, Department of Homeland
   Security; Fogarty International Center, National Institutes of Health;
   National Institute of Allergy and Infectious Diseases
   [EID-1R01AI074059-01]
FX This work was made possible by the generous support of the Faucett
   Family Foundation. We respectfully thank the DRC Ministry of Health and
   local health workers who were responsible for specimen collection and
   case investigation. Additional support for this study was provided by
   the National Institutes of Health, National Institute of Child Health
   and Human Development, Bethesda, MD, USA, by the joint National Science
   Foundation-National Institutes of Health Ecology of Infectious Diseases
   Program (grant number EF-0430146), by the RAPIDD program of the Science
   and Technology Directorate, Department of Homeland Security, by the
   Fogarty International Center, National Institutes of Health, and by the
   National Institute of Allergy and Infectious Diseases (grant number
   EID-1R01AI074059-01). We thank two anonymous reviewers for comments that
   improved the manuscript.
NR 40
TC 14
Z9 15
U1 1
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1612-9202
J9 ECOHEALTH
JI EcoHealth
PD MAR
PY 2011
VL 8
IS 1
BP 14
EP 25
DI 10.1007/s10393-010-0355-5
PG 12
WC Biodiversity Conservation; Ecology; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 862PI
UT WOS:000298105300002
PM 21069425
ER

PT J
AU Harrison, SA
   Abdurakhmanov, D
   Shiffman, ML
   Bakulin, I
   Mazur, W
   Rodriguez-Torres, M
   Silva, GF
   Cheinquer, H
   Messinger, D
   Mckenna, M
   Tatsch, F
   Reddy, KR
AF Harrison, S. A.
   Abdurakhmanov, D.
   Shiffman, M. L.
   Bakulin, I.
   Mazur, W.
   Rodriguez-Torres, M.
   Silva, G. F.
   Cheinquer, H.
   Messinger, D.
   Mckenna, M.
   Tatsch, F.
   Reddy, K. R.
CA PROGRESS Investigators
TI SVR RATES ARE HIGHER AMONG HCV G1 PATIENTS WITH ELEVATED LOW-DENSITY
   LIPOPROTEIN (LDL) LEVELS WHEN TREATED WITH INTENSIFIED DOSES OF
   PEGINTERFERON ALFA-2A (PEGASYS (R)) PLUS RIBAVIRIN
SO JOURNAL OF HEPATOLOGY
LA English
DT Meeting Abstract
CT 46th Annual Meeting of the
   European-Association-for-the-Study-of-the-Liver (EASL)
CY 2011
CL Berlin, GERMANY
SP European Assoc Study Liver (EASL)
C1 [Harrison, S. A.] Brooke Army Med Ctr, Houston, TX USA.
   [Abdurakhmanov, D.] Moscow Med Acad, Moscow, Russia.
   [Shiffman, M. L.] Bon Secours Hlth Syst, Liver Inst Virginia, Newport News, VA USA.
   [Bakulin, I.] Minist Def Russian Federat, State Postgrad Med Inst, Moscow, Russia.
   [Mazur, W.] Med Univ Silesia, Chorzow, Poland.
   [Rodriguez-Torres, M.] Fdn Invest Diego, Santurce, PR USA.
   [Silva, G. F.] Botucatu Sch Med, Botucatu, SP, Brazil.
   [Cheinquer, H.] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Messinger, D.] IST GmbH, Mannheim, Germany.
   [Mckenna, M.] Roche, Welwyn Garden City, England.
   [Tatsch, F.] Roche, Basel, Switzerland.
   [Reddy, K. R.] Univ Penn, Philadelphia, PA 19104 USA.
EM stephen.a.harrison@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2011
VL 54
SU 1
MA 431
BP S175
EP S175
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 856GC
UT WOS:000297625601011
ER

PT J
AU Khattab, M
   Shatat, M
   Eslam, M
   Mayada, A
   Hussein, A
   Gaber, S
   Harrison, S
AF Khattab, M.
   Shatat, M.
   Eslam, M.
   Mayada, A.
   Hussein, A.
   Gaber, S.
   Harrison, S.
TI ASSOCIATION OF SERUM ADIPOCYTOKINES WITH LIVER INJURY IN PATIENTS WITH
   CHRONIC HEPATITIS C GENOTYPE 4
SO JOURNAL OF HEPATOLOGY
LA English
DT Meeting Abstract
CT 46th Annual Meeting of the
   European-Association-for-the-Study-of-the-Liver (EASL)
CY MAR 30-APR 03, 2011
CL Berlin, GERMANY
SP European Assoc Study Liver (EASL)
C1 [Khattab, M.] Menia Univ, El Minia, Egypt.
   [Shatat, M.; Eslam, M.; Mayada, A.; Hussein, A.; Gaber, S.] Menia Univ, Al Minya, Egypt.
   [Harrison, S.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
EM mkhattabmed@hotmail.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2011
VL 54
SU 1
MA 1161
BP S458
EP S459
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 856GC
UT WOS:000297625602300
ER

PT J
AU Khattab, M
   Shatat, MS
   Eslam, M
   Mayada, A
   Hussein, A
   Gaber, S
   Harrison, SA
AF Khattab, M.
   Shatat, M. S.
   Eslam, M.
   Mayada, A.
   Hussein, A.
   Gaber, S.
   Harrison, S. A.
TI INSULIN RESISTANCE IN HEPATITIS C GENOTYPE 4 IS PARTIALLY MEDIATED BY
   VIRUS-SPECIFIC CHANGES IN ADIPOCYTOKINES
SO JOURNAL OF HEPATOLOGY
LA English
DT Meeting Abstract
CT 46th Annual Meeting of the
   European-Association-for-the-Study-of-the-Liver (EASL)
CY MAR 30-APR 03, 2011
CL Berlin, GERMANY
SP European Assoc Study Liver (EASL)
C1 [Khattab, M.] Menia Univ, El Minia, Egypt.
   [Shatat, M. S.; Eslam, M.; Mayada, A.; Hussein, A.; Gaber, S.; Harrison, S. A.] Menia Univ, Al Minya, Egypt.
   [Harrison, S. A.] Brooke Army Med Ctr, Dept Med 4, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA.
EM mkhattabmed@hotmail.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2011
VL 54
SU 1
MA 1160
BP S458
EP S458
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 856GC
UT WOS:000297625602299
ER

PT J
AU Sulkowski, MS
   Poordad, F
   Manns, MP
   Bronowicki, JP
   Reddy, KR
   Harrison, SA
   Afdhal, NH
   Boparai, N
   Sniukiene, V
   Burroughs, M
   Albrecht, JK
   Brass, CA
   Jacobson, IM
AF Sulkowski, M. S.
   Poordad, F.
   Manns, M. P.
   Bronowicki, J. -P.
   Reddy, K. R.
   Harrison, S. A.
   Afdhal, N. H.
   Boparai, N.
   Sniukiene, V.
   Burroughs, M.
   Albrecht, J. K.
   Brass, C. A.
   Jacobson, I. M.
TI ANEMIA DURING TREATMENT WITH PEGINTERFERON ALFA-2B/RIBAVIRIN WITH OR
   WITHOUT BOCEPREVIR IS ASSOCIATED WITH HIGHER SVR RATES: ANALYSIS OF
   PREVIOUSLY UNTREATED AND PREVIOUS-TREATMENT-FAILURE PATIENTS
SO JOURNAL OF HEPATOLOGY
LA English
DT Meeting Abstract
CT 46th Annual Meeting of the
   European-Association-for-the-Study-of-the-Liver (EASL)
CY 2011
CL Berlin, GERMANY
SP European Assoc Study Liver (EASL)
C1 [Sulkowski, M. S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Poordad, F.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
   [Manns, M. P.] Hannover Med Sch, D-3000 Hannover, Germany.
   [Bronowicki, J. -P.] Univ Henri Poincare Nancy, Vandoeuvre Les Nancy, France.
   [Reddy, K. R.] Univ Penn, Philadelphia, PA 19104 USA.
   [Harrison, S. A.] Brooke Army Med Ctr, San Antonio, TX USA.
   [Afdhal, N. H.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA.
   [Boparai, N.; Sniukiene, V.; Burroughs, M.; Albrecht, J. K.; Brass, C. A.] Merck, Whitehouse Stn, NJ USA.
   [Jacobson, I. M.] Weill Cornell Med Coll, New York, NY USA.
EM msulkowski@jhmi.edu
NR 0
TC 15
Z9 18
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2011
VL 54
SU 1
MA 476
BP S194
EP S195
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 856GC
UT WOS:000297625601056
ER

PT J
AU Torres, D
   Jones, FJ
   Shaw, J
   Williams, C
   Ward, JA
   Harrison, SA
AF Torres, D.
   Jones, F. J.
   Shaw, J.
   Williams, C.
   Ward, J. A.
   Harrison, S. A.
TI OPEN-LABEL PROSPECTIVE RANDOMIZED 48 WEEK CLINICAL TRIAL: ROSIGLITAZONE
   VERSUS ROSIGLITAZONE AND METFORMIN (AVANDAMET) VERSUS ROSIGLITAZONE AND
   LOSARTAN IN THE TREATMENT OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)
SO JOURNAL OF HEPATOLOGY
LA English
DT Meeting Abstract
CT 46th Annual Meeting of the
   European-Association-for-the-Study-of-the-Liver (EASL)
CY 2011
CL Berlin, GERMANY
SP European Assoc Study Liver (EASL)
C1 [Torres, D.] Walter Reed Army Med Ctr, Washington, DC USA.
   [Jones, F. J.; Shaw, J.; Williams, C.] Wilford Hall USAF Med Ctr, San Antonio, TX USA.
   [Ward, J. A.; Harrison, S. A.] Brooke Army Med Ctr, San Antonio, TX USA.
EM frances.jones1@us.army.mil
NR 0
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2011
VL 54
SU 1
MA 15
BP S7
EP S8
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 856GC
UT WOS:000297625600016
ER

PT J
AU Dietz, JS
AF Dietz, Jeffrey S.
TI BREAKING THE GROUND BARRIER: EQUAL PROTECTION ANALYSIS OF THE US
   MILITARY'S DIRECT GROUND COMBAT EXCLUSION OF WOMEN
SO MILITARY LAW REVIEW
LA English
DT Article
C1 USA, Off Judge Advocate Gen, Washington, DC 20310 USA.
RP Dietz, JS (reprint author), USA, Off Judge Advocate Gen, Washington, DC 20310 USA.
NR 98
TC 0
Z9 0
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2011
VL 207
BP 86
EP 154
PG 69
WC Law
SC Government & Law
GA 840ZV
UT WOS:000296482400002
ER

PT J
AU Linneweber, EC
AF Linneweber, Edward C.
TI TO TARGET, OR NOT TO TARGET: WHY 'TIS NOBLER TO THWART THE AFGHAN
   NARCOTICS TRADE WITH NONLETHAL MEANS
SO MILITARY LAW REVIEW
LA English
DT Article
C1 [Linneweber, Edward C.] USA, Washington, DC USA.
NR 73
TC 2
Z9 2
U1 0
U2 1
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2011
VL 207
BP 155
EP 202
PG 48
WC Law
SC Government & Law
GA 840ZV
UT WOS:000296482400003
ER

PT J
AU Ford, CM
AF Ford, Christopher M.
TI FROM NADIR TO ZENITH: THE POWER TO DETAIN IN WAR
SO MILITARY LAW REVIEW
LA English
DT Article
ID COMMANDER-IN-CHIEF; EXECUTIVE POWER; LOWEST EBB; TERRORISM; LAW
C1 USA, Washington, DC 20310 USA.
RP Ford, CM (reprint author), USA, Washington, DC 20310 USA.
NR 102
TC 2
Z9 2
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2011
VL 207
BP 203
EP 252
PG 50
WC Law
SC Government & Law
GA 840ZV
UT WOS:000296482400004
ER

PT J
AU Berg, EW
AF Berg, Edward W.
TI VIDEOTAPING CONFESSIONS: IT'S TIME
SO MILITARY LAW REVIEW
LA English
DT Article
ID CUSTODIAL INTERVIEWS
C1 [Berg, Edward W.] USA, Washington, DC USA.
RP Berg, EW (reprint author), 4 25th Airborne Brigade Combat Team, Ft Richardson, AK USA.
NR 19
TC 1
Z9 1
U1 0
U2 0
PU JUDGE ADVOCATE GENERALS SCHOOL
PI CHARLOTTESVILLE
PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA
SN 0026-4040
J9 MIL LAW REV
JI Milit. Law Rev.
PD SPR
PY 2011
VL 207
BP 253
EP 274
PG 22
WC Law
SC Government & Law
GA 840ZV
UT WOS:000296482400005
ER

PT J
AU Lesho, E
   Gleeson, T
   Summers, A
   Kirkup, B
   Chahine, M
   Babel, B
   Waterman, P
   Craft, D
AF Lesho, Emil
   Gleeson, Todd
   Summers, Amy
   Kirkup, Benjamin
   Chahine, Mohamad
   Babel, Britta
   Waterman, Paige
   Craft, David
TI Joint Collaboration Enhances Infection Control at Home and Abroad: The
   Maiden Voyage of the Multidrug-Resistant Organism Repository and
   Surveillance Network
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID FAVORABLE IMPACT; TECHNOLOGY; PATHOGENS
C1 [Lesho, Emil; Summers, Amy; Kirkup, Benjamin; Chahine, Mohamad; Waterman, Paige; Craft, David] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
   [Gleeson, Todd] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Babel, Britta] Natl Naval Med Ctr, Bethesda, MD 20814 USA.
RP Lesho, E (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RI Kirkup, Benjamin/C-3610-2009
OI Kirkup, Benjamin/0000-0002-8722-6218
NR 11
TC 5
Z9 5
U1 1
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2011
VL 176
IS 3
BP 241
EP 243
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BN
UT WOS:000295246000001
PM 21456346
ER

PT J
AU Graham, RF
   Hoskins, JD
   Cortijo, MP
   Barbee, GA
   Folio, LR
   Lutz, CC
AF Graham, Ross F.
   Hoskins, Jason D.
   Cortijo, Michael P.
   Barbee, George A.
   Folio, Les R.
   Lutz, Clifford C.
TI A Casualty Tracking System Modeled After Air Traffic Control Methodology
   Employed in a Combat Support Hospital in Iraq
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Graham, Ross F.; Hoskins, Jason D.] Uniformed Serv Univ Hlth Sci, Sch Med, Bethesda, MD 20814 USA.
   [Cortijo, Michael P.] USA, Emergency Med Technician Sect, Dept Emergency Med, Winn Army Community Hosp,CSH 47, Ft Stewart, GA 31314 USA.
   [Barbee, George A.] USA, Womack Army Med Ctr, MCXC DOEM, CSH 47, Ft Bragg, NC 28310 USA.
   [Folio, Les R.] NIH, Bethesda, MD 20892 USA.
   [Lutz, Clifford C.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA.
RP Graham, RF (reprint author), Uniformed Serv Univ Hlth Sci, Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
OI Barbee, George/0000-0002-9509-952X
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2011
VL 176
IS 3
BP 244
EP 245
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BN
UT WOS:000295246000002
PM 21456347
ER

PT J
AU Wallace, RF
   Wahi, MM
   Hill, OT
   Kay, AB
AF Wallace, Robert F.
   Wahi, Monika M.
   Hill, Owen T.
   Kay, Ashley B.
TI Rates of Ankle and Foot Injuries in Active-Duty US Army Soldiers,
   2000-2006
SO MILITARY MEDICINE
LA English
DT Article
ID STRESS-FRACTURE; RISK-FACTORS; ATHLETIC POPULATION; GENDER-DIFFERENCES;
   MILITARY RECRUITS; PHYSICAL-FITNESS; FEMALE RECRUITS; EPIDEMIOLOGY;
   YOUNG; SUSCEPTIBILITY
AB Ankle and foot injuries (AFI) are a major cause of Active-Duty Army (ADA) soldiers' time lost from training and combat operations. We used the Total Army Injury and Health Outcomes Database to compute the rates of AFI to identify high-risk ADA groups for the years 2000-2006. During this time, 16% of soldiers were clinically seen at least once for an AFI. Yearly, 60% to 70% of ADA soldiers with AFI had an ankle sprain/strain, and ankle sprain/strain had the highest 7-year rate of all AFIs (103 per 1,000). From 2000 to 2006, all AFI rates declined; however, enlisted male soldiers <= 30 years of age without an advanced degree were at highest risk. A history of an AFI in the previous 2 years increased AFI rates by 93% to 160%. Our findings provide preliminary evidence for identifying specific ADA groups at high risk of AFI; these groups should be targeted for preventive interventions.
C1 [Wallace, Robert F.; Wahi, Monika M.; Hill, Owen T.] USA, Environm Med Res Inst, Mil Performance Div, Injury Epidemiol Sect, Natick, MA 01760 USA.
   [Kay, Ashley B.] Social Sect Dev Strategies, Boston, MA 02118 USA.
RP Wallace, RF (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Injury Epidemiol Sect, 42 Kansas St, Natick, MA 01760 USA.
RI Hill, Owen/E-3643-2013
FU U.S. Army Research Institute of Environmental Medicine
FX This project was internally funded by the U.S. Army Research Institute
   of Environmental Medicine.
NR 29
TC 9
Z9 10
U1 0
U2 4
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2011
VL 176
IS 3
BP 283
EP 290
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BN
UT WOS:000295246000009
PM 21456354
ER

PT J
AU Keiser, PB
   Hamilton, L
   Broderick, M
AF Keiser, Paul B.
   Hamilton, Lanette
   Broderick, Michael
TI US Military Fatalities due to Neisseria meningitidis: Case Reports and
   Historical Perspective
SO MILITARY MEDICINE
LA English
DT Article
ID C MENINGOCOCCAL POLYSACCHARIDES; HUMAN IMMUNITY; UNITED-STATES; GROUP-B;
   DISEASE; INFECTIONS; VACCINES
AB Meningococcal disease has historically been associated with military populations, particularly during periods of mobilization. Although the U.S. military has now been engaged in conflicts for nearly a decade, the incidence of meningococcal disease in the U.S. population as a whole has reached historic lows. Despite vaccination of all service members in basic military training, the risk of meningococcal disease appears to be equal to or greater than that of the civilian population. These 3 case reports of recent fatalities in the U.S. military and their historic contexts illustrate the circumstances under which meningococcus can strike and highlight the need for continued vigilance in military populations.
C1 [Keiser, Paul B.] Walter Reed Army Inst Res, Dept Meningococcal Vaccines, Silver Spring, MD 20910 USA.
   [Hamilton, Lanette] Tripler Army Med Ctr, Dept Microbiol Serv, Honolulu, HI 96859 USA.
   [Broderick, Michael] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92106 USA.
RP Keiser, PB (reprint author), Walter Reed Army Inst Res, Dept Meningococcal Vaccines, 503 Robert Grant Rd,Room 3A16, Silver Spring, MD 20910 USA.
RI Valle, Ruben/A-7512-2013
NR 23
TC 1
Z9 1
U1 0
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2011
VL 176
IS 3
BP 308
EP 311
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BN
UT WOS:000295246000013
PM 21456358
ER

PT J
AU Jordan, NN
   Lee, SE
   Nowak, G
   Johns, NM
   Gaydos, JC
AF Jordan, Nikki N.
   Lee, Seung-eun
   Nowak, Gosia
   Johns, Natalie M.
   Gaydos, Joel C.
TI Chlamydia trachomatis Reported Among US Active Duty Service Members,
   2000-2008
SO MILITARY MEDICINE
LA English
DT Article
ID SEXUALLY-TRANSMITTED-DISEASES; PELVIC-INFLAMMATORY-DISEASE;
   UNITED-STATES MILITARY; FEMALE ARMY RECRUITS; INFECTION; PREVENTION;
   DIAGNOSES; SOLDIERS; WOMEN; RATES
AB Objectives: To review reported chlamydia infection trends in the U.S. military and identify reasons for differences. Methods: Defense Medical Surveillance System 2000-2008 reports for nondeployed, active duty members were studied. Incidence, rate ratios, and confidence intervals were generated. Age- and gender-specific rates were compared with US national rates. Screening and reporting policies and procedures were reviewed. Results: Overall incidence was 922 cases per 100,000 person-years, with considerable service variability (392-1,431 cases per 100,000 person-years in the Navy and Army, respectively). Navy-Marine Corps rates increased more than 2 fold in 2008. Rates were higher among women, minorities, and members under 25 years. Military rates exceeded national rates. Conclusions: The 2008 increase in Navy-Marine Corps rates may be due to the implementation of web-based reporting. Demographic differences were consistent with published reports. The civilian military disparity may reflect higher percentages of military at-risk women screened.
C1 [Jordan, Nikki N.] USA, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA.
   [Lee, Seung-eun; Gaydos, Joel C.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
   [Nowak, Gosia] USN, Marine Corps Publ Hlth Ctr, Portsmouth, VA 23708 USA.
   [Johns, Natalie M.] USAF, Med Support Agcy, Arlington, VA 22209 USA.
RP Jordan, NN (reprint author), USA, Publ Hlth Command Provis, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
NR 33
TC 9
Z9 11
U1 0
U2 8
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2011
VL 176
IS 3
BP 312
EP 319
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BN
UT WOS:000295246000014
PM 21456359
ER

PT J
AU Smith, AE
   Vedder, TG
   Hunter, PK
   Carr, MR
   Studer, MA
AF Smith, Ashley E.
   Vedder, Timothy G.
   Hunter, Patrick K.
   Carr, Michael R.
   Studer, Matthew A.
TI The Use of Newborn Screening Pulse Oximetry to Detect Cyanotic
   Congenital Heart Disease: A Survey of Current Practice at Army, Navy,
   and Air Force Hospitals
SO MILITARY MEDICINE
LA English
DT Article
ID DIAGNOSIS; MALFORMATIONS; CHILDREN; SURGERY; INFANCY
AB Objective: To determine the prevalence of newborn screening pulse oximetry (+POx) among military hospitals, including barriers to instituting protocols. Methods: An internet-based questionnaire was forwarded to the senior pediatricians at military hospitals worldwide supporting newborn deliveries. Results: Forty seven of 53 hospitals (88%) supporting deliveries responded to the survey. Thirty percent of hospitals utilize a +POx protocol. Eight centers cited no problems with implementation. All hospitals screened at >= 24 hours of life. The site of recording, positive values, and follow-up for positive screens varied. Cardiology consult and echocardiograin were not mandated. Most hospitals (34/47) are unable to obtain a pediatric cardiology consult without transfer. Few hospitals (9/47) utilize a telemedicine system. Seventy-five percent (24/32) of hospitals not utilizing a protocol are interested in instituting one. Conclusion: Though slightly less than one-third of military hospitals use a +POx, there is a greater interest in its use. More reliable consultative services and a robust telemedicine system may aid its implementation.
C1 [Smith, Ashley E.; Vedder, Timothy G.; Hunter, Patrick K.; Studer, Matthew A.] Tripler Army Med Ctr, Honolulu, HI 96819 USA.
   [Carr, Michael R.] USN, Med Ctr Portsmouth, Portsmouth, VA 23708 USA.
RP Smith, AE (reprint author), Tripler Army Med Ctr, 1 Jarret White Rd, Honolulu, HI 96819 USA.
NR 18
TC 1
Z9 1
U1 1
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD MAR
PY 2011
VL 176
IS 3
BP 343
EP 346
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BN
UT WOS:000295246000020
PM 21456365
ER

PT J
AU Imray, CHE
   Richards, P
   Greeves, J
   Castellani, JW
AF Imray, C. H. E.
   Richards, P.
   Greeves, J.
   Castellani, J. W.
TI Nonfreezing Cold-Induced Injuries
SO JOURNAL OF THE ROYAL ARMY MEDICAL CORPS
LA English
DT Article
ID IMMERSION FOOT SYNDROME; TRENCH FOOT; NERVE-CONDUCTION;
   PERIPHERAL-NERVE; FROSTBITE; ENHANCEMENT; TEMPERATURE; HYPOTHERMIA;
   DAMAGE; MODEL
AB Non-freezing cold injury (NFCI) is the Cinderella of thermal injuries and is a clinical syndrome that occurs when tissues are exposed to cold temperatures close to freezing point for sustained periods. NFCI is insidious in onset, often difficult to recognize and problematic to treat, and yet the condition accounts for significant morbidity in both military and civilians who work in cold conditions. Consequently recognition of those at risk, limiting their exposure and the appropriate and timely use of suitable protective equipment are essential steps in trying to reduce the impact of the condition. This review addresses the issues surrounding NFCI.
C1 [Imray, C. H. E.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwick Med Sch, Coventry CV2 2DX, W Midlands, England.
   [Imray, C. H. E.] UCL, Ctr Altitude Space & Extreme Environm Med, Inst Child Hlth, London WC1E 6BT, England.
   [Richards, P.; Greeves, J.] Trenchard Lines, Dept Occupat Med, Pewsey, Wilts, England.
   [Castellani, J. W.] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
RP Imray, CHE (reprint author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwick Med Sch, Coventry CV2 2DX, W Midlands, England.
EM Christopher.imray@uhcw.nhs.uk
NR 63
TC 15
Z9 15
U1 2
U2 6
PU RAMC JOURNAL PUBLICATIONS
PI CAMBERELY SURREY
PA HQ AMS, FASC, SLIM RD, CAMBERELY SURREY, GU15 4NP, ENGLAND
SN 0035-8665
J9 J ROY ARMY MED CORPS
JI J. R. Army Med. Corps
PD MAR
PY 2011
VL 157
IS 1
BP 79
EP 84
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 812FN
UT WOS:000294276600015
PM 21465916
ER

PT J
AU Florin, DA
   Davies, SJ
   Olsen, C
   Lawyer, P
   Lipnick, R
   Schultz, G
   Rowton, E
   Wilkerson, R
   Keep, L
AF Florin, David A.
   Davies, Stephen J.
   Olsen, Cara
   Lawyer, Phillip
   Lipnick, Robert
   Schultz, George
   Rowton, Edgar
   Wilkerson, Richard
   Keep, Lisa
TI Morphometric and Molecular Analyses of the Sand Fly Species Lutzomyia
   shannoni (Diptera: Psychodidae: Phlebotominae) Collected From Seven
   Different Geographical Areas in the Southeastern United States
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE Lutzomyia shannoni; canonical discriminant analysis; principal component
   analysis; internal transcribed spacer 2; cytochrome c oxidase subunit I
ID ITS2 RDNA SEQUENCES; PHYLOGENETIC-RELATIONSHIPS; MITOCHONDRIAL
   PSEUDOGENES; GENETIC-VARIABILITY; MADAGASCAR DIPTERA; OSSABAW ISLAND;
   FLIES DIPTERA; AEDES-AEGYPTI; NUCLEAR-DNA; N. SP
AB A morphometric and molecular study of adult male and female Lutzomyia shannoni (Dyar 1929) collected at seven different locations within the southeastern United States was conducted to assess the degree of divergence between the grouped specimens from each location. The collection locations were as follows: Fort Bragg, NC; Fort Campbell, KY; Fort Rucker, AL; Ossabaw Island, GA; Patuxent National Wildlife Research Refuge, MD; Suwannee National Wildlife Refuge, FL; and Baton Rouge, LA. Forty males and forty females from each location were analyzed morphometrically from 54 and 49 character measurements, respectively. In addition, the molecular markers consisting of the partial cytochrome c oxidase subunit I (from 105 sand flies: 15 specimens/collection site) and the partial internal transcribed spacer 2 (from 42 sand flies: six specimens/collection site) were compared. Multivariate analyses indicate that the low degree of variation between the grouped specimens from each collection site prevents the separation of any collection site into an entity that could be interpreted as a distinct population. The molecular analyses were in concordance with the morphometric study as no collection location grouped into a separate population based on the two partial markers. The grouped specimens from each collection site appear to be within the normal variance of the species, indicating a single population in the southeast United States. It is recommended that additional character analyses of L. shannoni based on more molecular markers, behavioral, ecological, and physiological characteristics, be conducted before ruling out the possibility of populations or a cryptic species complex within the southeastern United States.
C1 [Florin, David A.; Davies, Stephen J.; Olsen, Cara; Schultz, George; Keep, Lisa] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
   [Lawyer, Phillip] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA.
   [Lipnick, Robert] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA.
   [Rowton, Edgar; Wilkerson, Richard] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
RP Florin, DA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM david.florin@usuhs.mil
RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011
OI Rowton, Edgar/0000-0002-1979-1485
FU Uniformed Services University of the Health Sciences [R087WB]
FX We thank T. Mascari of Louisana State University and P. Obenauer of the
   United States Navy for providing sand flies from Baton Rouge, LA, and
   San Felasco Hammock State Preserve, FL, respectively. We also
   acknowledge F. Ruiz, Walter Reed Army Institute of Research, and Mike
   Flora, Uniformed Services University of the Health Sciences, for
   technical assistance. This work was supported by Uniformed Services
   University of the Health Sciences Intramural Grant R087WB: Risk for
   domestic transmission of leishmaniasis acquired by United States service
   members in Iraq/Afghanistan.
NR 69
TC 9
Z9 9
U1 1
U2 6
PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAR
PY 2011
VL 48
IS 2
BP 154
EP 166
DI 10.1603/ME10199
PG 13
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 810JM
UT WOS:000294121600007
PM 21485350
ER

PT J
AU Frances, SP
   Sithiprasasna, R
   Linthicum, KJ
AF Frances, Stephen P.
   Sithiprasasna, Ratana
   Linthicum, Kenneth J.
TI Laboratory Evaluation of the Response of Aedes aegypti and Aedes
   albopictus Uninfected and Infected With Dengue Virus to Deet
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE N, N-diethyl-3-methylbenzamide; Aedes aegypti; Aedes albopictus; dengue;
   Thailand
ID VALLEY FEVER VIRUS; FEEDING-BEHAVIOR; MOSQUITOS; REPELLENTS; CULICIDAE;
   DIPTERA
AB Laboratory studies were conducted to compare the response of Aedes aegypti (L.) and Aedes albopictus (Skuse) adults, uninfected and infected with four serotypes of dengue virus to a repellent containing 5% N, N-diethyl-3-methylbenzamide (deet). The results showed that mosquitoes infected with the four serotypes of dengue responded similarly to uninfected mosquitoes.
C1 [Frances, Stephen P.; Sithiprasasna, Ratana; Linthicum, Kenneth J.] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand.
RP Frances, SP (reprint author), Australian Army Malaria Inst, Enoggera, Qld 4051, Australia.
EM steve.frances@defence.gov.au
NR 18
TC 10
Z9 10
U1 2
U2 5
PU ENTOMOLOGICAL SOC AMER
PI LANHAM
PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA
SN 0022-2585
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD MAR
PY 2011
VL 48
IS 2
BP 334
EP 336
DI 10.1603/ME10120
PG 3
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA 810JM
UT WOS:000294121600027
PM 21485370
ER

PT J
AU Holthoff, EL
   Stratis-Cullum, DN
   Hankus, ME
AF Holthoff, Ellen L.
   Stratis-Cullum, Dimitra N.
   Hankus, Mikella E.
TI A Nanosensor for TNT Detection Based on Molecularly Imprinted Polymers
   and Surface Enhanced Raman Scattering
SO SENSORS
LA English
DT Article
DE molecular imprinting; surface enhanced Raman scattering; sensor;
   explosives detection
ID MOBILITY SPECTROMETRY; EXPLOSIVES; SENSORS; TRINITROTOLUENE; FILMS;
   MICROCANTILEVER; SPECTROSCOPY; XEROGELS
AB We report on a new sensor strategy that integrates molecularly imprinted polymers (MIPs) with surface enhanced Raman scattering (SERS). The sensor was developed to detect the explosive, 2,4,6-trinitrotoluene (TNT). Micron thick films of sol gel-derived xerogels were deposited on a SERS-active surface as the sensing layer. Xerogels were molecularly imprinted for TNT using non-covalent interactions with the polymer matrix. Binding of the TNT within the polymer matrix results in unique SERS bands, which allow for detection and identification of the molecule in the MIP. This MIP-SERS sensor exhibits an apparent dissociation constant of (2.3 +/- 0.3) x 10(-5) M for TNT and a 3 mu M detection limit. The response to TNT is reversible and the sensor is stable for at least 6 months. Key challenges, including developing a MIP formulation that is stable and integrated with the SERS substrate, and ensuring the MIP does not mask the spectral features of the target analyte through SERS polymer background, were successfully met. The results also suggest the MIP-SERS protocol can be extended to other target analytes of interest.
C1 [Holthoff, Ellen L.; Stratis-Cullum, Dimitra N.; Hankus, Mikella E.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA.
RP Holthoff, EL (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM ellen.holthoff@us.army.mil; dimitra.stratiscullum1@us.army.mil;
   mikella.hankus@us.army.mil
RI Hankus, Mikella/A-9005-2012; Stratis-Cullum, Dimitra/F-9363-2013
OI Stratis-Cullum, Dimitra/0000-0002-4832-6945
FU Army Research Laboratory Director's Research Initiative [DRI
   FY09-SED-13]
FX This research was supported by the Army Research Laboratory Director's
   Research Initiative (DRI FY09-SED-13).
NR 33
TC 79
Z9 82
U1 16
U2 159
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD MAR
PY 2011
VL 11
IS 3
BP 2700
EP 2714
DI 10.3390/s110302700
PG 15
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA 740IT
UT WOS:000288786900023
PM 22163761
ER

PT J
AU Roffman, K
AF Roffman, Karin
TI The Art of Self-Education in John Ashbery's Childhood Diaries
SO RARITAN-A QUARTERLY REVIEW
LA English
DT Article
C1 US Mil Acad, West Point, NY 10996 USA.
RP Roffman, K (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU RARITAN-A QUARTERLY REVIEW
PI NEW BRUNSWICK
PA RUTGERS UNIV, 31 MINE ST, NEW BRUNSWICK, NJ 08903 USA
SN 0275-1607
J9 RARITAN
JI Raritan-Q. Rev.
PD SPR
PY 2011
VL 30
IS 4
BP 94
EP 116
PG 23
WC Literary Reviews
SC Literature
GA 774GS
UT WOS:000291374300008
ER

PT J
AU Teyhen, DS
   George, SZ
   Dugan, JL
   Williamson, J
   Neilson, BD
   Childs, JD
AF Teyhen, Deydre S.
   George, Steven Z.
   Dugan, Jessica L.
   Williamson, Jared
   Neilson, Brett D.
   Childs, John D.
TI Inter-Rater Reliability of Ultrasound Imaging of the Trunk Musculature
   Among Novice Raters
SO JOURNAL OF ULTRASOUND IN MEDICINE
LA English
DT Article
DE internal oblique; lumbar multifidus; rectus abdominis; transversus
   abdominis; ultrasound
ID LOW-BACK-PAIN; LUMBAR MULTIFIDUS MUSCLE; LEG RAISE TEST; MOTOR CONTROL
   EXERCISE; POSTERIOR PELVIC PAIN; ABDOMINAL-MUSCLES; TRANSVERSUS
   ABDOMINIS; DRAWING-IN; MEASUREMENT ERROR; HEALTHY-SUBJECTS
AB Objective-The purpose of this study was to determine the inter-rater reliability of ultrasound imaging for assessing trunk muscle morphologic characteristics at rest and while contracted among different pairs of novice raters. The secondary purpose was to compare 3 different measurement techniques for assessing lateral abdominal muscle thickness.
   Methods-A single-group repeated measures reliability study was conducted on 21 healthy participants (mean +/- SD, 21.5 +/- 4.4 years; 5 female and 16 male) without low back pain. Ultrasound images of the transversus abdominis, internal oblique, rectus abdominis, and lumbar multifidus muscles were obtained by different pairs of novice raters in a counterbalanced order. All raters received a standardized training program before obtaining measurements.
   Results-The intraclass correlation coefficient (1,3) point estimates ranged from 0.86 to 0.94; the standard error of the measurement ranged from 0.04 to 0.16 cm for the thickness values and 0.67 cm(2) for the cross-sectional area of the rectus abdominis muscle. There was no meaningful difference between the different measurement techniques used to analyze the lateral abdominal muscles.
   Conclusions-Good to excellent reliability was obtained for all measures by novice raters. Minimal differences in reliability were noted between the different measurement techniques to assess lateral abdominal muscle thickness.
C1 [Teyhen, Deydre S.] Baylor Univ, USA, Dept Phys Therapy, Attn MCCS HGE PT,Med Dept Ctr & Sch,Doctrol Progr, Ft Sam Houston, TX 78234 USA.
   [Teyhen, Deydre S.; Dugan, Jessica L.] Ctr Phys Therapy Res, San Antonio, TX USA.
   [George, Steven Z.] Univ Florida, Ctr Pain Res & Behav Hlth, Dept Phys Therapy, Gainesville, FL USA.
   [Williamson, Jared] 75th Ranger Regiment, Battal 2, Ft Lewis, WA USA.
   [Neilson, Brett D.] Evidence Mot, Louisville, KY USA.
RP Teyhen, DS (reprint author), Baylor Univ, USA, Dept Phys Therapy, Attn MCCS HGE PT,Med Dept Ctr & Sch,Doctrol Progr, 3150 Stanley Rd,Room 1303, Ft Sam Houston, TX 78234 USA.
EM deydre.teyhen@amedd.army.mil
FU US Department of Defense [PR054098]; Congressionally Directed
   Peer-Reviewed Medical Research Program, Fort Detrick, Maryland
   [W81XWH-06-1-0564]
FX We thank Alison Wright, DPT, CPT Nicole Hall, DPT, CPT Sonrie Gervacio,
   DPT, CPT Joseph Lopez, DPT, Jason Mitchler, DPT, LT Joshua Shumway, SPT,
   LT Brittany Mc-Cright, SPT, John May, DPT, Elizabeth Sampey, DPT, and
   Alexandria Gentles, DPT, for their contributions to image acquisition
   and measurement. We also thank the physical therapy students at the
   University of Texas Health Science Center and at the US Army-Baylor
   University for their support of this research study. The Prevention of
   Low Back Pain in the Military trial is supported by the peer-review
   medical research program of the US Department of Defense (PR054098),
   Congressionally Directed Peer-Reviewed Medical Research Program
   (W81XWH-06-1-0564), Fort Detrick, Maryland. The views expressed herein
   are those of the authors and do not reflect the official policy or
   position of Brooke Army Medical Center, the US Army Medical Department,
   the US Army Office of the Surgeon General, the Department of the Army,
   the Department of the Air Force, the Department of Defense, or the US
   Government.
NR 50
TC 16
Z9 17
U1 1
U2 7
PU AMER INST ULTRASOUND MEDICINE
PI LAUREL
PA SUBSCRIPTION DEPT, 14750 SWEITZER LANE, STE 100, LAUREL, MD 20707-5906
   USA
SN 0278-4297
EI 1550-9613
J9 J ULTRAS MED
JI J. Ultrasound Med.
PD MAR
PY 2011
VL 30
IS 3
BP 347
EP 356
PG 10
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA 770ZJ
UT WOS:000291126700009
PM 21357556
ER

PT J
AU Bayless, ER
   Mandell, WA
   Ursic, JR
AF Bayless, E. R.
   Mandell, Wayne A.
   Ursic, James R.
TI Accuracy of Flowmeters Measuring Horizontal Groundwater Flow in an
   Unconsolidated Aquifer Simulator
SO GROUND WATER MONITORING AND REMEDIATION
LA English
DT Article
ID BOREHOLE FLOWMETER; WATER FLOW
AB Borehole flowmeters that measure horizontal flow velocity and direction of groundwater flow are being increasingly applied to a wide variety of environmental problems. This study was carried out to evaluate the measurement accuracy of several types of flowmeters in an unconsolidated aquifer simulator. Flowmeter response to hydraulic gradient, aquifer properties, and well-screen construction was measured during 2003 and 2005 at the U.S. Geological Survey Hydrologic Instrumentation Facility in Bay St. Louis, Mississippi. The flowmeters tested included a commercially available heat-pulse flowmeter, an acoustic Doppler flowmeter, a scanning colloidal borescope flowmeter, and a fluid-conductivity logging system. Results of the study indicated that at least one flowmeter was capable of measuring borehole flow velocity and direction in most simulated conditions. The mean error in direction measurements ranged from 15.1 degrees to 23.5 degrees and the directional accuracy of all tested flowmeters improved with increasing hydraulic gradient. The range of Darcy velocities examined in this study ranged 4.3 to 155 ft/d. For many plots comparing the simulated and measured Darcy velocity, the squared correlation coefficient (r2) exceeded 0.92. The accuracy of velocity measurements varied with well construction and velocity magnitude. The use of horizontal flowmeters in environmental studies appears promising but applications may require more than one type of flowmeter to span the range of conditions encountered in the field. Interpreting flowmeter data from field settings may be complicated by geologic heterogeneity, preferential flow, vertical flow, constricted screen openings, and nonoptimal screen orientation.
C1 [Bayless, E. R.] US Geol Survey, Indiana Water Sci Ctr, Indianapolis, IN 46278 USA.
   [Mandell, Wayne A.] USA, Ctr Environm, Aberdeen Proving Ground, MD USA.
   [Ursic, James R.] US EPA, Chicago, IL USA.
RP Bayless, ER (reprint author), US Geol Survey, Indiana Water Sci Ctr, Indianapolis, IN 46278 USA.
EM ebayless@usgs.gov
NR 30
TC 8
Z9 8
U1 3
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1069-3629
J9 GROUND WATER MONIT R
JI Ground Water Monit. Remediat.
PD SPR
PY 2011
VL 31
IS 2
BP 48
EP 62
DI 10.1111/j.1745-6592.2010.01324.x
PG 15
WC Water Resources
SC Water Resources
GA 763FT
UT WOS:000290541500003
ER

PT J
AU Linkov, F
   Bovbjerg, D
   Delany, J
   Goodpaster, B
   Jakicic, J
   Lenzner, D
   Lin, Y
   Maxwell, G
   Felix, A
   Lokshin, A
AF Linkov, F.
   Bovbjerg, D.
   Delany, J.
   Goodpaster, B.
   Jakicic, J.
   Lenzner, D.
   Lin, Y.
   Maxwell, G.
   Felix, A.
   Lokshin, A.
TI Longitudinal evaluation of cancer-associated biomarkers before and after
   weight loss in RENEW study participants: Implications for cancer risk
   reduction
SO GYNECOLOGIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Linkov, F.; Bovbjerg, D.; Delany, J.; Jakicic, J.; Lenzner, D.; Lin, Y.; Felix, A.; Lokshin, A.] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
   [Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2011
VL 121
IS 1
SU 1
MA 86
BP S38
EP S38
DI 10.1016/j.ygyno.2010.12.093
PG 1
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 760AF
UT WOS:000290292300087
ER

PT J
AU Rungruang, B
   Miller, A
   Richard, S
   Hamilton, C
   Rodriguez, N
   Bookman, M
   Maxwell, G
   Krivak, T
   Horowitz, N
AF Rungruang, B.
   Miller, A.
   Richard, S.
   Hamilton, C.
   Rodriguez, N.
   Bookman, M.
   Maxwell, G.
   Krivak, T.
   Horowitz, N.
TI Should stage IIIC ovarian cancer be further stratified by
   intraperitoneal versus retroperitoneal-only disease? A Gynecologic
   Oncology Group study
SO GYNECOLOGIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Rungruang, B.; Richard, S.; Krivak, T.] UPMC, Magee Womens Hosp, Pittsburgh, PA USA.
   [Miller, A.] Gynecol Oncol Grp, Buffalo, NY USA.
   [Hamilton, C.; Maxwell, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   [Rodriguez, N.; Horowitz, N.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Bookman, M.] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2011
VL 121
IS 1
SU 1
MA 29
BP S13
EP S14
DI 10.1016/j.ygyno.2010.12.036
PG 2
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 760AF
UT WOS:000290292300030
ER

PT J
AU Ziebarth, A
   Durst, J
   Subramaniam, A
   Nguyen, N
   Smith, H
   Killian, E
   Kim, K
   Leath, C
   Straughn, J
   Alvarez, R
AF Ziebarth, A.
   Durst, J.
   Subramaniam, A.
   Nguyen, N.
   Smith, H.
   Killian, E.
   Kim, K.
   Leath, C.
   Straughn, J.
   Alvarez, R.
TI Completed versus aborted radical hysterectomy for node-positive stage I
   cervical cancer
SO GYNECOLOGIC ONCOLOGY
LA English
DT Meeting Abstract
C1 [Ziebarth, A.; Durst, J.; Subramaniam, A.; Nguyen, N.; Smith, H.; Killian, E.; Kim, K.; Straughn, J.; Alvarez, R.] Univ Alabama, Birmingham, AL USA.
   [Leath, C.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0090-8258
J9 GYNECOL ONCOL
JI Gynecol. Oncol.
PD MAR
PY 2011
VL 121
IS 1
SU 1
MA 245
BP S106
EP S106
DI 10.1016/j.ygyno.2010.12.252
PG 1
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 760AF
UT WOS:000290292300246
ER

PT J
AU Suzuki, R
   Goebert, D
   Ahmed, I
   Lu, B
AF Suzuki, Rika
   Goebert, Deborah
   Ahmed, Iqbal
   Lu, Brett
TI Cultural Differences in Perceptions of Dementia Among Asian Ethnic
   Minorities in Hawaii
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Association-of-Geriatric-Psychiatry
CY MAR 18-21, 2011
CL San Antonio, TX
SP Amer Assoc Geriat Psychiat
C1 [Suzuki, Rika; Goebert, Deborah; Lu, Brett] Univ Hawaii, John A Burns Sch Med, Dept Psychiat, Honolulu, HI 96822 USA.
   [Ahmed, Iqbal] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-7481
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD MAR
PY 2011
VL 19
IS 3
SU 1
BP S91
EP S92
PG 2
WC Geriatrics & Gerontology; Gerontology; Psychiatry
SC Geriatrics & Gerontology; Psychiatry
GA 753PD
UT WOS:000289791000098
ER

PT J
AU McLain, DE
   Horn, TL
   Detrisac, CJ
   Lindsey, CY
   Smith, LA
AF McLain, Daniel E.
   Horn, Thomas L.
   Detrisac, Carol J.
   Lindsey, Changhong Y.
   Smith, Leonard A.
TI Progress in Biological Threat Agent Vaccine Development: A Repeat-Dose
   Toxicity Study of a Recombinant Ricin Toxin A-Chain (rRTA) 1-33/44-198
   Vaccine (RVEc) in Male and Female New Zealand White Rabbits
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE ricin toxin; biological threat agent; recombinant vaccine; NOAEL
ID VASCULAR LEAK SYNDROME; LECTINS; MICE; CELL; VALIDATION; INCREASES;
   PROTEINS; PLANTS; ABRIN
AB A recombinant ricin toxin A-chain 1-33/44-198 vaccine (RVEc) was administered to male and female New Zealand white (NZW) rabbits (10/sex/group) in a repeat-dose toxicity study. The RVEc vaccine was administered on study days 1, 29, 57, and 85 via intramuscular (IM) injection (0, 100, or 200 mu g/dose). All study animals were observed throughout treatment until euthanized and submitted for necropsy on study day 88 or 99 (recovery period). There were no treatment-related or toxicologically significant effects observed. There were no statistically significant differences noted in the antibody titers and/or concentrations in 100 mu g RVEc-treated animals when compared to 200 mu g RVEc-treated animals, suggesting that both doses produced comparable antibody titers/concentrations during the study. The highest immune response was observed on study day 99 (ie, 2 weeks after the last dose). The immune response observed demonstrated that RVEc is biologically active in the rabbit model, with no apparent marked sex differences.
C1 [Lindsey, Changhong Y.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
   [McLain, Daniel E.] Walker Downey & Associates Inc, Verona, WI USA.
   [Horn, Thomas L.] IIT Res Inst, Chicago, IL USA.
   [Detrisac, Carol J.] Pathol Associates Inc, Charles River Labs, Chicago, IL USA.
RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM Leonard.Smith@amedd.army.mil
FU Joint Science and Technology Office for Chemical-Biological defense,
   Defense Threat Reduction Agency
FX The author(s) disclosed receipt of the following financial support for
   the research and/or authorship of this article: the Joint Science and
   Technology Office for Chemical-Biological defense, Defense Threat
   Reduction Agency.
NR 34
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Z9 12
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD MAR
PY 2011
VL 30
IS 2
BP 143
EP 152
DI 10.1177/1091581810396730
PG 10
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 757UR
UT WOS:000290113700001
PM 21378370
ER

PT J
AU Reed, CW
   Brown, ME
   Sanchez, A
   Wu, WM
   Buttolph, AM
AF Reed, Christopher W.
   Brown, Mitchell E.
   Sanchez, Alejandro
   Wu, Weiming
   Buttolph, Adele M.
TI The Coastal Modeling System Flow Model (CMS-Flow): Past and Present
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Coastal hydrodynamics; sediment transport; morphodynamic modeling
AB CMS-Flow is a coupled time-dependent circulation, sediment transport and morphodynamic model based on the numerical solution of the mass, momentum and transport equations on a Cartesian (quad-tree) grid network with both explicit and implicit solvers. It has been developed and is currently supported under the Coastal Inlets Research Program (CIRP) conducted at the U.S. Army Engineer Research and Development Center (ERDC), Coastal and Hydraulics Laboratory (CHL). The model's primary function is to support multi-disciplinary research teams and conduct practical projects at coastal inlets. CMS-Flow has been designed with a relatively simple code structure which allows for rapid development and inclusion of new sediment transport algorithms, while always being accessible to the general modeling community, including both USACE and commercial users. Today, CMS-Flow is an integral component of the CIRP, providing technology for simulating hydrodynamics, waves, sediment transport and morphology for short and long timeframes in coastal inlets, adjacent beaches, navigation channels and bays.
C1 [Reed, Christopher W.] URS Corp, Tallahassee, FL 32317 USA.
   [Brown, Mitchell E.; Sanchez, Alejandro] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Wu, Weiming] Univ Mississippi, Natl Ctr Computat Hydrosci & Engn, University, MS 38677 USA.
   [Buttolph, Adele M.] Coastal Anal LLC, Enterprise, OR 97828 USA.
RP Reed, CW (reprint author), URS Corp, 1625 Summit Lake Dr, Tallahassee, FL 32317 USA.
EM Chris_reed@urscorp.com
NR 9
TC 4
Z9 4
U1 0
U2 6
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 1
EP 6
DI 10.2112/SI59-001.1
PG 6
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500002
ER

PT J
AU Lin, L
   Demirbilek, Z
   Mase, H
AF Lin, Lihwa
   Demirbilek, Zeki
   Mase, Hajime
TI Recent Capabilities of CMS-Wave: A Coastal Wave Model for Inlets and
   Navigation Projects
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Navigation; coastal inlets; numerical wave modeling; nearshore wave
   processes
ID ENERGY-BALANCE-EQUATION; TRANSFORMATION
AB The Coastal Inlets Research Program (CIRP) of the U.S. Army Engineer Research and Development Center (ERDC), Coastal and Hydraulics Laboratory (CHL) has developed a nearshore spectral wave transformation numerical, model to address needs of the U.S. Army Corps of Engineers (USACE) navigation projects. The model is called. CMS-Wave and is part of Coastal Modeling System (CMS) for wave estimates in the vicinity of coastal and estuarine navigation channels. It can simulate important wave processes at coastal inlets including wave diffraction, refraction, reflection, wave breaking and dissipation mechanisms, wave-current interaction, and wave generation and :growth. This paper describes recent improvements in CMS-Wave that include semi-empirical estimates of wave run-up and overtopping, nonlinear wave-wave interactions, and wave dissipation over muddy bottoms. CMS-Wave may be used with nested grids and variable rectangular cells in a rapid mode to assimilate full-plane wave generation for circulation and sediment transport models. A brief description of these recent capabilities is provided.
C1 [Lin, Lihwa; Demirbilek, Zeki] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Mase, Hajime] Kyoto Univ, Disaster Prevent Res Inst, Kyoto 6110011, Japan.
RP Lin, L (reprint author), USA, Engineer Res & Dev Ctr, 3909Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Lihwa.Lin@usace.army.mil
NR 25
TC 2
Z9 3
U1 0
U2 0
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 7
EP 14
DI 10.2112/SI59-002.1
PG 8
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500003
ER

PT J
AU Wu, WM
   Sanchez, A
   Zhang, ML
AF Wu, Weiming
   Sanchez, Alejandro
   Zhang, Mingliang
TI An Implicit 2-D Shallow Water Flow Model on Unstructured Quadtree
   Rectangular Mesh
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Shallow water flow equations; two-dimensional; finite volume; numerical
   model; quadtree rectangular mesh
ID FLUID-FLOWS; ALGORITHM; GMRES
AB An implicit finite volume scheme is developed to solve the depth-averaged 2-D shallow water flow equations. The computational mesh consists of rectangular cells, with quadtree technology incorporated to locally refine the mesh around structures of interest or where the topography and/or flow properties change sharply. The grid nodes are numbered by means of an unstructured index system for more flexibility. The governing equations are solved using the SIMPLEC algorithm on non-staggered grid to handle the coupling of water level and velocity. In this non-staggered system, primary variables u-, v-velocity, and water level are stored on the same set of grid points, and fluxes at cell faces are determined using the Rhie and Chow's momentum interpolation method to avoid spurious checkerboard oscillations. The discretized algebraic equations are solved iteratively using the GMRES method. The model has been tested against measurement data for steady flow around a spur-dyke in a laboratory flume and tidal flows in Gironde Estuary, France and Grays Harbor, USA. The model reasonably well reproduces the temporal and spatial variations of water level and current speed observed in the measurements. The laboratory test has demonstrated that the quadtree mesh is cost-effective, while the two field cases have shown that the model is very stable and handles wetting and drying efficiently.
C1 [Wu, Weiming; Zhang, Mingliang] Univ Mississippi, Natl Ctr Computat Hydrosci & Engn, University, MS 38677 USA.
   [Sanchez, Alejandro] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Wu, WM (reprint author), Univ Mississippi, Natl Ctr Computat Hydrosci & Engn, University, MS 38677 USA.
FU ERDC, US Army Corps of Engineers, Vicksburg
FX This study is supported by the Coastal Inlets Research Program, ERDC, US
   Army Corps of Engineers, Vicksburg, MS. Drs. Nicholas C. Kraus, Julie D.
   Rosati, Lihwa Lin, Chris Reed, Alan K. Zundel, Mr. Mitchell Brown and
   other colleagues in the CIRP group are acknowledged for their valuable
   comments and suggestions.
NR 38
TC 7
Z9 7
U1 0
U2 5
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 15
EP 26
DI 10.2112/SI59-003.1
PG 12
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500004
ER

PT J
AU Sanchez, A
   Wu, WM
AF Sanchez, Alejandro
   Wu, Weiming
TI A Non-Equilibrium Sediment Transport Model for Coastal Inlets and
   Navigation Channels
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Sediment transport; coastal inlet; channel infilling; finite volume;
   numerical model
ID SUSPENDED SEDIMENT; UNIFIED VIEW; CURRENTS; WAVES; FLOW
AB This paper presents a depth-averaged sediment transport model with emphasis on morphodynamic processes near coastal inlets and navigation channels. The model solves the depth-averaged two-dimensional non-equilibrium transport equation of total-load sediment, considering bed-material hiding and exposure, avalanching and sediment transport over hard bottoms. The model is coupled with a depth-averaged circulation model and a spectral wave transformation model. Predicted bed changes are compared with measurements for two laboratory experiments of channel infilling and in a field study at Shinnecock Inlet, Long Island, NY. The results indicate that the model is capable of predicting the general trends of morphology change and provides a useful tool for engineering applications such as coastal sediment management, navigation channel maintenance, and beach erosion protection.
C1 [Sanchez, Alejandro] USA, Corps Engineers Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
   [Wu, Weiming] Univ Mississippi, Natl Ctr Computat Hydrosci & Engn, University, MS 38677 USA.
RP Sanchez, A (reprint author), USA, Corps Engineers Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Alejandro.Sanchez@usace.army.mil
FU U.S. Army Corps of Engineers
FX This work was conducted in part through funding from the Coastal
   Modeling System work unit of the Coastal Inlets Research Program (CIRP)
   of the U.S. Army Corps of Engineers. Permission was granted by the
   Chief, U. S. Army Corps of Engineers, to publish this information. We
   appreciate the help and support of Dr. Nicholas C. Kraus, Dr. Julie D.
   Rosati, Dr. Lihwa Lin, Mr. Mitch Brown, Dr. Alan Zundel, and others in
   CIRP group.
NR 47
TC 3
Z9 4
U1 1
U2 6
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 39
EP 48
DI 10.2112/SI59-005.1
PG 10
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500006
ER

PT J
AU Wang, P
   Beck, TM
   Roberts, TM
AF Wang, Ping
   Beck, Tanya M.
   Roberts, Tiffany M.
TI Modeling Regional-Scale Sediment Transport and Medium-Term Morphology
   Change at a Dual-Inlet System Examined with the Coastal Modeling System
   (CMS): A Case Study at Johns Pass and Blind Pass, West-Central Florida
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Nearshore sediment transport; coastal morphology; numerical modeling;
   dredging; tidal inlets; ebb tidal delta; channel infilling; tides;
   waves; Florida
ID RANDOM WAVE TRANSFORMATION; ENERGY-BALANCE-EQUATION; BAY
AB The Coastal Modeling System (CMS), developed by the US Army Engineer Research and Development Center's (ERDC) Coastal Inlets Research Program (CIRP), is applied to model morphology change at a dual-inlet system, the Johns Pass and Blind Pass system in West-Central Florida. The CMS combines computation of current, wave, and sediment transport, leading to the prediction of morphology change at tidal inlets and the surrounding beaches. Medium-term CMS runs, with simulated times of 1.2 to 1.6 years, were completed and compared with extensive field data. Stronger tidal flow through the dominating Johns Pass and weaker flow through the secondary Blind Pass were calculated, indicating that the model reproduced an essential aspect of this interactive two-inlet system. The complicated wave refraction and breaking over the ebb tidal deltas and along the adjacent shorelines were accurately modeled, leading to a realistic representation of the wave-current interaction. Wave-breaking induced elevated sediment suspension and transport were described by the model. The predicted morphology change agreed well with field data. The CMS captured several key spatial trends of morphology change, e.g., erosion along the downdrift beach and accretion at the attachment point. The computed 32,000 m(3)/yr sedimentation volume in the dredge pit at the updrift side of Blind Pass matched the measured value of 35,000 m(3)/yr with a similar spatial distribution pattern, suggesting that the calculated net longshore sediment transport rates are accurate. The computed sedimentation rate of 60,000 m(3)/yr at a designed dredge pit on Johns Pass ebb-delta agrees with the generally accepted gross longshore transport rate. Rapid and large morphology change in response to high wave-energy events is predicted and is consistent with field observations.
C1 [Wang, Ping; Roberts, Tiffany M.] Univ S Florida, Dept Geol, Tampa, FL 33620 USA.
   [Beck, Tanya M.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Wang, P (reprint author), Univ S Florida, Dept Geol, Tampa, FL 33620 USA.
FU US Army Engineer Research and Development Center's (ERDC); Pinellas
   County Florida; University of South Florida
FX This study was supported by US Army Engineer Research and Development
   Center's (ERDC) Coastal Inlet Research Program (CIRP), Pinellas County
   Florida, and the University of South Florida. Permission was granted by
   Headquarters, U.S. Army Corps of Engineers, to publish this information.
NR 31
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U1 0
U2 2
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 49
EP 60
DI 10.2112/SI59-006.1
PG 12
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500007
ER

PT J
AU Kana, TW
   Rosati, JD
   Traynum, SB
AF Kana, Timothy W.
   Rosati, Julie D.
   Traynum, Steven B.
TI Lack of Evidence for Onshore Sediment Transport from Deep Water at
   Decadal Time Scales: Fire Island, New York
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Coastal erosion; sediment budget; Fire Island; depth of closure;
   cross-shore transport; longshore transport; sediment source; offshore
   shoals; beach profile; littoral sediment; tidal inlets; ebb tidal delta;
   mesoscale
ID INNER-CONTINENTAL-SHELF; LONG-ISLAND; GEOLOGIC FRAMEWORK;
   SOUTH-CAROLINA; ATLANTIC SHELF; COMBINED WAVE; SHOREFACE; EVOLUTION;
   COAST; SHORELINE
AB Fire Island, New York, is a 50-kilometer-long barrier island that has remained positionally stable without any formation of breach inlets for nearly 200 years. Some researchers have attributed its stability to a major supply of sand moving onshore from relatively deep water (i.e.,> 10 m depths). Others have demonstrated via sediment budgets that the principal sand sources at decadal to century time scales arc littoral sediments derived from eroding beaches, bluffs, and cannibalization of inlet shoals in shallower depths (i.e., <= 10 m). Published sediment budgets indicate that the quantity in question is of the order 105 m(3)/yr. The possibility that this deep-water source of sand is significant, active, and persistent at decadal to century time scales has led to reluctance to mine deep-water shoals for beach nourishment of Fire Island. Herein, the authors review five factors related to the potential for a significant deep-water sand source in this setting: (1) spatial and temporal frames of reference necessary for this flux of sand; (2) studies of scour and sediment transport over offshore features; (3) sediment size distribution across the foreshore; (4) depth of closure (DOC); and (5) contribution of abandoned inlet shoals. The authors conclude that evidence for an onshore flux of sediment (i.e., order of 10(5) m3/yr) is lacking and suggest that reluctance to mine the offshore for beach nourishment is unfounded.
C1 [Kana, Timothy W.; Traynum, Steven B.] Coastal Sci & Engn Inc, Columbia, SC 29202 USA.
   [Rosati, Julie D.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Mobile, AL 36628 USA.
RP Kana, TW (reprint author), Coastal Sci & Engn Inc, POB 8056, Columbia, SC 29202 USA.
EM tkana@coastalscience.com
FU U.S. Army Corps of Engineers [DACW51-81-C-0030]; New York State Coastal
   Partnership to Coastal Science & Engineering, Inc.; U.S. Army Engineer
   Research and Development Center (ERDC)
FX This study is an offshoot of independent work by the authors in
   connection with the USACE Fire Island to Montauk Point Reformulation
   Study and related research of the south shore of Long Island. The first
   author's work was funded by the U.S. Army Corps of Engineers (Contract
   DACW51-81-C-0030, T. Kana, co-principal investigator) and a grant from
   the New York State Coastal Partnership to Coastal Science & Engineering,
   Inc. The second author was funded in original work by the Reformulation
   Study as well as the Coastal Inlets Research Program of the U.S. Army
   Engineer Research and Development Center (ERDC). The authors thank three
   anonymous reviewers for their helpful comments on the manuscript. Dr.
   Rosati acknowledges permission granted by the Headquarters, U.S. Army
   Corps of Engineers, to publish this paper. The views expressed in the
   paper are those of the authors, and are not to be construed as official
   positions of their respective organiza Lions.
NR 70
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PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 61
EP 75
DI 10.2112/SI59-007.1
PG 15
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500008
ER

PT J
AU Williams, DD
   Kraus, NC
AF Williams, Deidre D.
   Kraus, Nicholas C.
TI Seasonal Change in Nearshore and Channel Morphology at Packery Channel,
   A New Inlet Serving Corpus Christi, Texas
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Shoreline change; tidal inlet; tidal current; Hurricane Ike;
   seasonality; wind fronts; beach profile; beach nourishment; seawall
AB Packery Channel is an artificial inlet that occupies a historic ephemeral pathway between Corpus Christi Bay and the Gulf of Mexico. In 2005, the inlet was opened by Hurricane Emily during its construction and has remained open and navigable for more than 4 years. The shallow-draft channel has not required maintenance dredging despite episodic shoaling during storms, including Hurricane Ike. Stability of the inlet and adjacent beach is attributed to location in the southeast corner of Corpus Christi Bay, receiving augmented ebb flow by wind setup accompanying winter fronts. The ebb current, with speed sometimes exceeding 1.0 m/s, scours sediment deposited during the summer months, thereby maintaining channel depth adequate for water exchange and navigation. After the channel opened, a deposition basin initially served as the main sediment repository for sediment scoured from the bay side. Entrance channel shoaling began to increase in 2008, initiated by 15,000 m(3) of beach sand that entered the channel during Hurricane Ike. Subsequent shoaling is attributed to unrestricted wind-blown transport enhanced by drought. Since completion of the 430-m long dual jetties in 2006, an ebb-tidal delta has not formed. Ebb delta development is suppressed by a strong longshore current and longshore bar formation that alternates in direction seasonally, and by strong bursts of ebb flow during winter. The inlet is located in a region of nearly balanced longshore sediment transport, indicated by near-symmetric shoreline response at each jetty. The shoreline within a 1-km zone of the inlet advanced at a rate of 7.5 m/yr, whereas along the 18-km monitoring area it receded at a rate of 1.6 m/yr, reflecting in part the influence of Hurricane Ike. Channel performance tracks closely with that reported in the original design, with stability to date exceeding those 1997 predictions.
C1 [Williams, Deidre D.] Texas A&M Univ, Conrad Blucher Inst Surveying & Sci, Div Nearshore Res, Corpus Christi, TX 78412 USA.
   [Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Williams, DD (reprint author), Texas A&M Univ, Conrad Blucher Inst Surveying & Sci, Div Nearshore Res, 6300 Ocean Dr, Corpus Christi, TX 78412 USA.
EM Williams@lighthouse.tamucc.edu
NR 20
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PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 86
EP 97
DI 10.2112/SI59-009.1
PG 12
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500010
ER

PT J
AU Beck, TM
   Kraus, NC
AF Beck, Tanya M.
   Kraus, Nicholas C.
TI New Ebb-Tidal Delta at an Old Inlet, Shark River Inlet, New Jersey
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Tidal inlet; sediment bypassing; sediment transport; dredging; channel
   infilling; morphologic modeling; inlet processes
AB Shark River Inlet, located on the north New Jersey coast, is served by a federal navigation channel that has until recently required little maintenance dredging. Although possessing a small estuary, the inlet is hydraulically efficient because of the small width to depth ratio of its entrance that is stabilized by parallel jetties. After placement of approximately 4.8 million rn(3) of beach nourishment to the north and south of the inlet as part of an erosion-control project conducted in the late 1990s, inlet maintenance increased beyond that anticipated. Analysis of channel and nearshore surveys indicates that an ebb-tidal delta is forming where none had existed previously, attributed to the recent availability of sand from the beach nourishment and a lack of sand prior to that construction. Jetty tip shoals also encroach on the channel, dependent on season, with longshore transport directed primarily to the north during summer (the predominant direction of transport) and to the south during winter. Formation of the ebb delta must be accounted for in the sand budget of the adjacent beaches. After conducting a GIS analysis of ebb delta growth to understand geomorphic trends, the Coastal Modeling System (CMS) was established to numerically simulate waves, current, sand transport, and morphology change. The CMS reproduced observed trends in ebb-delta growth, and multi-year simulations indicate the time scale of approach to dynamic equilibrium of the ebb delta and establishment of natural sand bypassing at the inlet.
C1 [Beck, Tanya M.; Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Beck, TM (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Tanya.M.Beck@usace.army.mil
FU U.S. Army Engineer District, New York; U.S Army Engineer Research and
   Development Center
FX This study was jointly funded by the U.S. Army Engineer District, New
   York, and the Coastal Inlet Research Program (CIRP) at the U.S Army
   Engineer Research and Development Center. Discussions with and
   information provided by New York District staff Lynn M. Bocamazo, Adam
   B. Devenyi, Jessica Fischer, Gerlyn T. Perlas, John F. Tavolaro, and
   Edward Wrocenski are greatly appreciated. Permission was granted by
   Headquarters, U.S. Army Corps of Engineers, to publish this information.
NR 26
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U1 1
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PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 98
EP 110
DI 10.2112/SI59-010.1
PG 13
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500011
ER

PT J
AU Bokuniewicz, HJ
   Kraus, NC
   Munger, S
   Slattery, M
   Coffey, R
AF Bokuniewicz, Henry J.
   Kraus, Nicholas C.
   Munger, Sophie
   Slattery, Michael
   Coffey, Ruth
TI Monitoring Incipient Breaching at an Artificial Inlet: Georgica Pond,
   New York
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Beach; tide gauge; salinity
AB Georgica Pond, on Long Island's ocean coast in East Hampton, NY, is normally separated from the ocean by a beach about 100 m wide, but mechanically opened to the Atlantic Ocean. Observations of the breach were made for three days, until it closed naturally. A channel 6 m wide was dug on April 23, 2008. The water level in the Pond was initially 1.46 m higher than the ocean. Upon completion of the channel, pond water rushed seaward through the new inlet at a speed reaching 3.7 m/sec. The flow was supercritical with a hydraulic jump forming at the inlet mouth. The cut widened in an hour by the progressive, sudden collapse of steep sections of bank along its length, growing at a rate of about 0.2 m/min, then slowing to about 0.1 m/min, eventually stabilizing at a width of 43 m. Forty-two hours after opening, the salinity in the pond suddenly jumped from 7 to 19. Pond salinity reached 26 about four clays after the inlet opened. Over the course of five days, the water level in the pond fell 0.5 m, draining 530,000 m(3) of water into the ocean. About 3,800 m(3) of sand formed an ephemeral ebb shoal that was gradually swept to the west and back into the western beaches by wave-induced longshore transport. The inlet closed by April 28. On May 2, 8.5 days after the opening, salinity dropped to 13 and continued to fall slowly as freshwater drained into the pond.
C1 [Bokuniewicz, Henry J.; Slattery, Michael; Coffey, Ruth] SUNY Stony Brook, Sch Marine & Atmospher Sci, Stony Brook, NY 11794 USA.
   [Kraus, Nicholas C.; Munger, Sophie] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Bokuniewicz, HJ (reprint author), SUNY Stony Brook, Sch Marine & Atmospher Sci, Stony Brook, NY 11794 USA.
EM hbokuniewicz@notes.cc.sunysb.edu
FU U.S. Army Corps of Engineers (USACE)
FX This project was done with the cooperation of Diane McNally, Clerk, and
   the Trustees of the Town of East Hampton as well as with assistance of
   Larry Penny, Department of Natural Resources, Town of East Hampton. We
   were aided in the field work by Dr. Frank S. Buonaiuto and Michael J.
   Morgan, U.S. Army Corps of Engineers, New York District; Dr. Charlie
   Flagg and Zak Duval from Stony Brook University; Tim Miller of George
   Walbridge Surveyors PC, East Hampton, NY; Rory MacNish from Cornell
   Cooperative Extension; and Henry Feldman and Dan Hoffman, Stony Brook
   University. Chris Schubert of the U. S. Geological Survey maintains the
   Georgica Pond tide gauge. Aerial photography was taken by Aram
   Terchunian of First Coastal Corporation. This work was supported by the
   Coastal Inlets Research Program of the U.S. Army Corps of Engineers
   (USACE). Permission was granted by HQ, USACE, to publish this
   information.
NR 15
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U1 2
U2 6
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 111
EP 117
DI 10.2112/SI59-011.1
PG 7
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500012
ER

PT J
AU Hanson, H
   Kraus, NC
AF Hanson, Hans
   Kraus, Nicholas C.
TI Long-Term Evolution of a Long-Term Evolution Model
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Shoreline change; shoreline response; Cascade; GENESIS; beach fill;
   groins; detached breakwaters; jetties; SBEACH
ID NUMERICAL-SIMULATION; DUNE EROSION; BEACH; TRANSPORT
AB This paper reviews the 25-plus year history of significant developments of the GENESIS shoreline response model. Topics discussed are line sources and sinks of sand, representation of shore-normal structures including natural sand bypassing, wave transmission by and shoreline response to shore-parallel structures, seawalls, migrating longshore sand waves, seasonal variation by cross-shore sand transport, sand transport due to tidal and wind-generated currents, preservation of the regional shape of the shoreline, and the interaction between the beach berm and the dunes behind it. Such developments have been done in a consistent way, based on thorough literature reviews, beta testing, comparison to beach behavior, and quality control. The challenges have been not only to represent the features themselves, but to be consistent to the basic assumptions of shoreline modeling theory. Through these added capabilities, GENESIS has evolved to meet the challenges of modern, multi-scale, long-term coastal engineering applications.
C1 [Hanson, Hans] Lund Univ, Dept Water Resources Engn, S-22100 Lund, Sweden.
   [Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Hanson, H (reprint author), Lund Univ, Dept Water Resources Engn, Box 118, S-22100 Lund, Sweden.
EM Hans.Hanson@tvrl.lth.se
FU Swedish Council for Building Research
FX We would like to acknowledge collaboration and discussions with
   colleague Dr. Magnus Larson, University of Lund, over the years. We
   would also like to thank Mr. Mark Gravens for contributing to the
   administration and quality control of model development over the years,
   and for review of a draft of this paper. Funding for the 25+ years of
   research and development of GENESIS originated from several U.S. Army
   Corps of Engineers research programs. Initial funding of HH for GENESIS
   development was provided by the Swedish Council for Building Research.
   This paper was produced as an activity of the Geomorphic Evolution work
   unit of the Coastal Inlets Research Program administered at the U.S.
   Army Engineer Research and Development Center, Coastal and Hydraulics
   Laboratory. Permission was granted by Headquarters, U.S. Army Corps of
   Engineers, to publish this information.
NR 61
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U1 0
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PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 118
EP 129
DI 10.2112/SI59-012.1
PG 12
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500013
ER

PT J
AU Reed, CW
   Lin, L
AF Reed, Christopher W.
   Lin, Lihwa
TI Analysis of Packery Channel Public Access Boat Ramp Shoreline Failure
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Coastal hydrodynamics; flow modeling; wave modeling; Packery Channel
AB The shoreline stabilization adjacent to the public access boat ramp in the Packery Channel basin has been damaged in two separate events. For the shoreline damage at the boat ramp bulkhead, toe scour is the likely mechanism for failure. Typical sources of hydrodynamic forcing that can lead to toe erosion include storm currents, locally generated storm waves, and offshore storm waves propagating into the basin through Packery Channel. Quantitative analysis of storm induced wind generated waves and currents eliminated them as possible causes of the damage. However, photographic and movie evidence indicate the presence of low-frequency low-amplitude waves propagated into the basin and impacted the boat ramp. The Coastal System Model (CMS) was used to simulate a range of these low-frequency low-amplitude waves and the results demonstrated that these waves could produce sufficient flows in the vicinity of the boat ramp shoreline to cause the damage. Subsequent modeling was used to develop design criteria for additional shoreline stabilization.
C1 [Reed, Christopher W.] URS Corp, Tallahassee, FL 32317 USA.
   [Lin, Lihwa] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Reed, CW (reprint author), URS Corp, 1625 Summit Lake Dr, Tallahassee, FL 32317 USA.
EM Chris_reed@urscorp.com
NR 5
TC 0
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U1 0
U2 0
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 150
EP 155
DI 10.2112/SI59-015.1
PG 6
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500016
ER

PT J
AU Grzegorzewski, AS
   Cialone, MA
   Wamsley, TV
AF Grzegorzewski, Alison Sleath
   Cialone, Mary A.
   Wamsley, Ty V.
TI Interaction of Barrier Islands and Storms: Implications for Flood Risk
   Reduction in Louisiana and Mississippi
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Barrier islands; storm surge; coastal restoration; numerical modeling
ID WAVE CONTINUITY EQUATION; SHALLOW-WATER EQUATIONS; SOUTHERN LOUISIANA;
   HURRICANE KATRINA; SURGE
AB Coastal barrier islands are natural lines of defense and an integral part of a comprehensive flood risk reduction and management plan. A high resolution numerical modeling system capable of representing complicated coastal landscapes and simulating all the primary relevant physical processes is applied to better understand the influence of barrier island restoration on hurricane surge propagation. Model results indicate that barrier island restoration may significantly alter surge pathways and flood volumes of surge reaching inland coastal areas as open water passes become the dominant flow mechanism during a storm event. However, the exclusion of the morphologic evolution of a barrier island during a storm's passage is a significant limitation with the existing numerical models and is currently under development. The results in this paper demonstrate the need to include morphologic changes to fully evaluate the impact barrier islands have on water levels at the mainland coast.
C1 [Grzegorzewski, Alison Sleath; Cialone, Mary A.; Wamsley, Ty V.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Grzegorzewski, AS (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
FU U.S. Army Engineer District, New Orleans; MOdeling Relevant PHysics Of
   Systems (MORPHOS) Work Unit of the Flood; U.S. Army Corps of Engineers
FX This work was performed as part of a study supported by the U.S. Army
   Engineer District, New Orleans, with additional support provided by the
   MOdeling Relevant PHysics Of Systems (MORPHOS) Work Unit of the Flood
   and Coastal Research Program, U.S. Army Corps of Engineers. The authors
   express sincere gratitude to Dr. Alex McCorquodale of the University of
   New Orleans and Dr. Roy Messaros of USACE New York District for
   providing feedback on this paper. Permission to publish this paper was
   granted by the Office, Chief of Engineers, US Army Corps of Engineers.
NR 40
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PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 156
EP 164
DI 10.2112/SI59-016.1
PG 9
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500017
ER

PT J
AU Silveira, TM
   Kraus, NC
   Psuty, NP
   Andrade, F
AF Silveira, Tanya M.
   Kraus, Nicholas C.
   Psuty, Norbert P.
   Andrade, Francisco
TI Beach Nourishment on Troia Peninsula, Portugal
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Beach fill design; Regional sediment management; beneficial use
AB Troia peninsula, located on the western coast of Portugal, is undergoing tourism development, including construction of a marina. The marina basin was created by dredging a coastal stretch on the northern terminus of the peninsula on the estuarine side, making available beach-quality sediment for nourishment. A study was carried out to identify potential applications and opportunities to place the dredged sand in a beneficial manner. Many variables were considered in the study design in incorporating pre-project beach profile surveys and sediment sampling. Beach-fill design and placement procedures were proposed according to the purpose and constraints of the particular site, while recognizing the implications of the nourishment in a regional sediment management context. Between October 2006 and March 2007, 286,000 m(3) of sand was placed along four beach sectors with a total alongshore extent of 1,700 in in the vicinity of the new marina and the Troia Roman Ruins archeological site. The emplacements included dune, beach berm, and beach face nourishment, providing restoration of beaches and dunes and also increased buffering capacity in an area of damage to cultural resources of the peninsula. A monitoring program was deployed to assess performance and impacts of the nourishment on adjacent areas, and to identify problems and their causes. The surveys of August 2007 indicate that a significant part of the emplaced sand had been mobilized alongshore promoting the spreading of the fill material to down-drift areas while inducing a general reduction in the beach face slope, and attaining a more natural beach profile.
C1 [Silveira, Tanya M.; Psuty, Norbert P.] Rutgers State Univ, Inst Marine & Coastal Sci, Highlands, NJ 07732 USA.
   [Andrade, Francisco] Univ Lisbon, Fac Ciencias, Ctr Oceanog, Lab Maritimo Guia, P-2750374 Cascais, Portugal.
   [Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Silveira, TM (reprint author), Rutgers State Univ, Inst Marine & Coastal Sci, 74 Magruder Rd,Unit 3, Highlands, NJ 07732 USA.
EM mendes@marine.rutgers.edu
RI Silveira, Tanya/C-9011-2013; Mendes Silveira, Tanya/M-7007-2013
OI Mendes Silveira, Tanya/0000-0003-4465-0542
FU Luso-American Foundation (FLAD)/Institute of Marine Research (IMAR)
FX Data were obtained in the framework of the "Environmental monitoring
   program for the marina and new ferry dock of the Troiaresort," conducted
   by the Institute of Marine Research (IMAR) for SONAE turismo. Tanya
   Mendes Silveira was funded by the Luso-American Foundation
   (FLAD)/Institute of Marine Research (IMAR), to travel to the United
   States and spend time at the Coastal and Hydraulics Laboratory, US Army
   Corps of Engineers in Vicksburg, MS, and at the Institute of Marine and
   Coastal Sciences, Rutgers University, NJ.
NR 18
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PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 173
EP 180
DI 10.2112/SI59-018.1
PG 8
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500019
ER

PT J
AU Bocamazo, LM
   Grosskopf, WG
   Buonuiato, FS
AF Bocamazo, Lynn M.
   Grosskopf, William G.
   Buonuiato, Frank S.
TI Beach Nourishment, Shoreline Change, and Dune Growth at Westhampton
   Beach, New York, 1996-2009
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Beachfill; renourishment; Long Island; groin modifications
AB Westhampton Beach is located on the barrier island between Moriches Inlet and Shinnecock Inlet, along the south shore of Long Island, New York. This vulnerable area has been subject to a number of beach erosion control measures under the authority of the Fire Island to Montauk Point, New York Beach Erosion and Hurricane Protection (FIMP) project as well as the related Westhampton Interim Project The Westhampton Interim Project, initiated in 1996, provided for beachfill placement, dune construction west of the groin field, periodic beachfill renourishment until 2027, and a tapering of the groins at the western edge of the groin field in order to provide a smooth transition to the downdrift barrier beaches. Project coastal processes monitoring since 1996 has shown that the shoreline position in the project area has been stable and there has been volumetric growth of the dune field west of the groin field. The 10-year average volumetric loss in the project area of 180,000 cubic yards per year is very similar to the 759,000 cubic yards (190,000 cubic yards per year) renourishment volume placed in 2005 after a four-year renourishment cycle. The largest rate of dune growth west of the groin field from initial construction to February 2009 is approximately 2.0 cy/ft-yr while the average rate of growth is 1.25 cy/ft-yr. Good stewardship of the beach and dune system will allow the Westhampton Interim Project to be maintained and provide the storm damage reduction purposes for which it was designed.
C1 [Bocamazo, Lynn M.; Buonuiato, Frank S.] US Army Engineer Dist, New York, NY 10278 USA.
   [Grosskopf, William G.] Offshore & Coastal Technol Inc, Chadds Ford, PA 19317 USA.
RP Bocamazo, LM (reprint author), US Army Engineer Dist, 26 Fed Plaza, New York, NY 10278 USA.
EM lynn.m.bocamazo@usace.army.mil
NR 20
TC 6
Z9 6
U1 2
U2 17
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 181
EP 191
DI 10.2112/SI59-019.1
PG 11
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500020
ER

PT J
AU Wamsley, TV
   Waters, JP
   King, DB
AF Wamsley, Ty V.
   Waters, Jeffery P.
   King, David B.
TI Performance of Experimental Low Volume Beach Fill and Clay Core Dune
   Shore Protection Project
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Jefferson County Texas; Tropical cyclone; Hurricane Ivan
AB An experimental shoreline protection project in Jefferson County, TX was constructed and monitored as part of the National Shoreline Erosion Control Development and Demonstration Program. The project determined the effectiveness of a nontraditional, low volume beach fill at reducing erosion of underlying clay layers and evaluated the performance of a clay core dune compared with that of a sand filled dune. Four cells were constructed on the beach face having 0.18 or 0.25 mm sand and fill volumes of 6 or 12 cy/ft. A fifth control cell had no fill. A 2500 ft long dune was constructed, with half being composed entirely of sand and half being composed of a clay core and sand cap. The project was constructed during the summer of 2004 and was impacted by Hurricane Ivan in September 2004 and later by the same storm as Tropical Storm Ivan in October 2004. An evaluation of profiles and other data taken before, between, and after these storms shows that the clay core dune survived the storms much more intact than the dune constructed entirely of sand. The clay core dune suffered minor scarping at its seaward toe, while up to the seaward half of the sand dune was removed in some sections. The results of the low volume beach fill were also promising. The fill performed well by protecting the underlying clay layer from erosion, but interpretation of the results is complicated by the presence of geotextile tube groins that were placed to contain the fill.
C1 [Wamsley, Ty V.; Waters, Jeffery P.; King, David B.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Wamsley, TV (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM ty.v.wamsley@usace.army.mil
FU National Shoreline Erosion Control Development and Demonstration Program
FX Project funding was provided by the National Shoreline Erosion Control
   Development and Demonstration Program.
NR 13
TC 0
Z9 0
U1 2
U2 6
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 202
EP 210
DI 10.2112/SI59-021.1
PG 9
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500022
ER

PT J
AU Rosati, JD
   Lawton, C
AF Rosati, Julie Dean
   Lawton, Crorey
TI Channel Shoaling with Deepening of Houma Navigation Channel at Cat
   Island Pass, Louisiana
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Shoaling; infilling; sediment transport; sediment budget; regional
   sediment management; channel deepening and widening
ID MISSISSIPPI RIVER DELTA; TIDAL INLET; EVOLUTION; MODEL
AB ROSATI, J.D. and LAWTON, C., 2011. Channel Shoaling with Deepening of Houma Navigation Channel at Cat Island Pass, Louisiana. In: Roberts, T.M., Rosati, J.D., and Wang, P. (eds.), Proceedings, Symposium to Honor Dr. Nicholas C. Kraus, Journal of Coastal Research, Special Issue, No. 59, pp. 256-265. West Palm Beach (Florida), ISSN 0749-0208.
   This study evaluated the potential increase in shoaling and associated sources of sediment as a result of proposed channel improvements for the Houma Navigation Channel in the vicinity of Cat Island Pass, Louisiana. Using morphologic change data and historical maintenance dredging rates, historical and forecasted with-deepening sediment budgets were developed. Conclusions from this study were that deepening the channel from 5.5 m to 6.1 m relative to Mean Low Gulf, a local low water datum, would increase the shoaling rate from the present 191,000 m(3)/year to 220,000 m(3)/year, and the likely source of shoaling would be sediment that is presently bypassed naturally. It was recommended that all environmentally-acceptable sediment dredged from Cat Island Pass be placed on the downdrift barrier island, East Island, part of the Isle Dernieres barrier island system. Clays and silts should be placed on the bayside of the island and sand similar to or coarser than the existing beach sand should be placed downdrift of the nodal zone on the Gulf side of East Island. Historically, sediment dredged from Cat Island Pass has been placed in designated dredged material disposal sites located 760 m west of the channel. Based on morphologic change in the region from 1980 to 2006, it appears that sediment may be transported from this placement site to deposit back into the channel. It is recommended that, if sediment cannot be placed on either East Island or Timbalier Island, that the dredged material disposal site be moved further to the west, away from the channel. Finally, based on movement of Timbalier Island and Cat Island Pass over the past 100 years, it is recommended that the channel be moved further to the west to avoid future impingement by Timbalier Island. Based on the results of this and other studies of the Houma Navigation Channel, channel realignment was approved in 2009, and authorization of the deepened channel is being requested during 2010.
C1 [Rosati, Julie Dean] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Mobile, AL 36628 USA.
   [Lawton, Crorey] USA, Corps Engn, New Orleans, LA 70118 USA.
RP Rosati, JD (reprint author), USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 109 St Joseph St, Mobile, AL 36628 USA.
EM Julie.D.Rosati@usace.army.mil
FU U.S. Army Engineer District, New Orleans; U.S Army Engineer Research and
   Development Center
FX This study was jointly funded by the U.S. Army Engineer District, New
   Orleans, and the Coastal Inlet Research Program (CIRP) at the U.S Army
   Engineer Research and Development Center. Mr. Darin Lee at the Louisiana
   Office of Coastal Protection and Restoration graciously provided
   historical bathymetric and shoreline data from the Barrier Island
   Comprehensive Monitoring Program, which was used in formulating the
   sediment budget. Thank you to Mr. James Rosati III and Dr. David B. King
   for helpful review comments. Permission was granted by Headquarters,
   U.S. Army Corps of Engineers, to publish this information.
NR 43
TC 0
Z9 0
U1 2
U2 7
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 59
BP 256
EP 265
DI 10.2112/SI59-027.1
PG 10
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YW
UT WOS:000290126500028
ER

PT J
AU Evans, R
   Negus, C
   Antczak, A
   Hadid, A
   Arbel, Y
   Yanovich, R
   Moran, D
AF Evans, Rachel
   Negus, Charles
   Antczak, Amanda
   Hadid, Amir
   Arbel, Yael
   Yanovich, Ran
   Moran, Dani
TI MALE RECRUITS WITH STRESS REACTION OF THE TIBIA EXHIBIT HIGHER DENSITY
   AND SMALLER GEOMETRY THAN UNINJURED RECRUITS
SO OSTEOPOROSIS INTERNATIONAL
LA English
DT Meeting Abstract
CT 1st IOF-ESCEO Pre-Clinical Symposium
CY MAR 23-26, 2011
CL Valencia, SPAIN
C1 [Evans, Rachel; Antczak, Amanda] USA, Environm Med Res Inst, Natick, MA 01760 USA.
   [Evans, Rachel] Brooke Army Med Ctr, Ctr Intrepid, San Antonio, TX USA.
   [Negus, Charles] L3 Jaycor, San Diego, CA USA.
   [Hadid, Amir; Arbel, Yael; Yanovich, Ran; Moran, Dani] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel.
   [Moran, Dani] Ariel Univ, Ctr Samaria, Ariel, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-941X
J9 OSTEOPOROSIS INT
JI Osteoporosis Int.
PD MAR
PY 2011
VL 22
SU 1
BP 317
EP 317
PG 1
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 738SI
UT WOS:000288662000571
ER

PT J
AU Reif, MK
   Macon, CL
   Wozencraft, JM
AF Reif, Molly K.
   Macon, Christopher L.
   Wozencraft, Jennifer M.
TI Post-Katrina Land-Cover, Elevation, and Volume Change Assessment along
   the South Shore of Lake Pontchartrain, Louisiana, USA
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article
DE Hurricane Katrina; LIDAR; topography; land cover; recovery; change
   detection; Lake Pontchartrain; New Orleans; Joint Airborne LIDAR
   Bathymetry Technical Center of Expertise
ID REMOTELY-SENSED DATA; HURRICANE-KATRINA; LIDAR DATA; CLASSIFICATION;
   VEGETATION; COASTAL; FUSION; MISSISSIPPI; ALABAMA; IMAGERY
AB Advances in remote-sensing technology have led to its increased use for posthurricane disaster response and assessment; however, the use of the technology is underutilized in the recovery phase of the disaster management cycle. This study illustrates an example of a postdisaster recovery assessment by detecting coastal land cover, elevation, and volume changes using 3 years of post-Katrina hyperspectral and light detection and ranging data collected along the south shore of Lake Pontchartrain, Louisiana. Digital elevation models and basic land-cover classifications were generated for a 34-km(2) study area for 2005, 2006, and 2007. A change detection method was used to assess postdisaster land-cover, elevation, and volume changes. Results showed that the vegetation classes had area increases, whereas bare ground/roads and structures classes had area decreases. Overall estimated volume changes included a net volume decrease of 1.6 x 10(6) m(3) in 2005 to 2006 and a net volume decrease of 2.1 x 10(6) m(3) in 2006 to 2007 within the study area. More specifically, low vegetation and bare ground/roads classes had net volume increases, whereas medium and tall vegetation and structures classes had net volume decreases. These changes in land cover, elevation, and volume illustrate some of the major physical impacts of the disaster and ensuing recovery. This study demonstrates an innovative image fusion approach to assess physical changes and postdisaster recovery in a residential, coastal environment.
C1 [Reif, Molly K.] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Joint Airborne LIDAR Bathymetry Tech Ctr EXpertis, Kiln, MS 39556 USA.
   [Wozencraft, Jennifer M.] US Army Corps Engineers, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Joint Airborne LIDAR Bathymetry Tech Ctr EXpertis, Kiln, MS 39556 USA.
RP Reif, MK (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Joint Airborne LIDAR Bathymetry Tech Ctr EXpertis, 7225 Stennis Airport Rd,Suite 100, Kiln, MS 39556 USA.
EM Molly.k.Reif@usace.army.mil
FU USACE Headquarters; System-Wide Water Resources Program (SWWRP)
FX The projects, analysis, and resulting data described herein, unless
   otherwise noted, were obtained from work performed by the JALBTCX and
   funded by USACE Headquarters and the System-Wide Water Resources Program
   (SWWRP). The use of trade names does not constitute an endorsement in
   the use of these products by the U.S. Government. Permission was granted
   by the Chief of Engineers to publish this work.
NR 48
TC 2
Z9 2
U1 2
U2 15
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
EI 1551-5036
J9 J COASTAL RES
JI J. Coast. Res.
PD SPR
PY 2011
SI 62
BP 30
EP 39
DI 10.2112/SI_62_4
PG 10
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 757YX
UT WOS:000290126600004
ER

PT J
AU Champagne, VK
   Helfritch, DJ
   Dinavahi, SPG
   Leyman, PF
AF Champagne, Victor K.
   Helfritch, Dennis J.
   Dinavahi, Surya P. G.
   Leyman, Phillip F.
TI Theoretical and Experimental Particle Velocity in Cold Spray
SO JOURNAL OF THERMAL SPRAY TECHNOLOGY
LA English
DT Article
DE aluminum; CFD; modeling; nozzle; velocity measurement
ID DEPOSITION; DESIGN; NOZZLE; DRAG
AB In an effort to corroborate theoretical and experimental techniques used for cold spray particle velocity analysis, two theoretical and one experimental methods were used to analyze the operation of a nozzle accelerating aluminum particles in nitrogen gas. Two-dimensional (2D) axi-symmetric computations of the flow through the nozzle were performed using the Reynolds averaged Navier-Stokes code in a computational fluid dynamics platform. 1D, isentropic, gas-dynamic equations were solved for the same nozzle geometry and initial conditions. Finally, the velocities of particles exiting a nozzle of the same geometry and operated at the same initial conditions were measured by a dual-slit velocimeter. Exit plume particle velocities as determined by the three methods compared reasonably well, and differences could be attributed to frictional and particle distribution effects.
C1 [Champagne, Victor K.] USA, Res Lab, Aberdeen, MD USA.
   [Helfritch, Dennis J.] Dynam Sci, Aberdeen, MD USA.
   [Dinavahi, Surya P. G.] Lockheed Martin Co, Army Res Lab, Aberdeen Proving Ground, MD USA.
   [Leyman, Phillip F.] Data Matrix Solut, Sterling, VA USA.
RP Champagne, VK (reprint author), USA, Res Lab, Aberdeen, MD USA.
EM surya.dinavahi@us.army.mil
NR 14
TC 11
Z9 11
U1 2
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9630
J9 J THERM SPRAY TECHN
JI J. Therm. Spray Technol.
PD MAR
PY 2011
VL 20
IS 3
BP 425
EP 431
DI 10.1007/s11666-010-9530-z
PG 7
WC Materials Science, Coatings & Films
SC Materials Science
GA 754JH
UT WOS:000289850400004
ER

PT J
AU Ravanes, JM
   Cellona, RV
   Balagon, M
   Abalos, RM
   Walsh, GP
   Walsh, DS
AF Ravanes, Jesus M.
   Cellona, Roland V.
   Balagon, Marivic
   Abalos, Rodolfo M.
   Walsh, Gerald P.
   Walsh, Douglas S.
TI LONGITUDINAL OCULAR SURVEY OF 202 FILIPINO PATIENTS WITH MULTI-BACILLARY
   (MB) LEPROSY TREATED WITH 2 YEAR WHO-MULTIPLE DRUG THERAPY
SO SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
LA English
DT Article
DE leprosy; lepra reactions; ocular disease; WHO multi-drug therapy (MDT)
ID MULTIBACILLARY LEPROSY; BLINDNESS; COMPLICATIONS; CLOFAZIMINE; MORBIDITY
AB The aim of this study was to describe the ocular conditions in multi-bacillary (MB) leprosy patients treated with 2 year WHO multiple drug therapy (MDT), consisting of dapsone, clofazimine and rifampin, a regimen expected to reduce ocular complications of leprosy. We conducted comprehensive eye examinations in 202 Filipino MB leprosy patients before, during, and after WHO 2 year MDT. Assessments were carried out for at least 5 years. Inflammatory "lepra" reactions occurred in 62% (reversal reaction, 52%; erythema nodosum leprosum, 10%); most were mild. Eye abnormalities consisted mostly of diminished corneal sensitivity before MDT (6%) and lagopthalmos (n = 7,3.4%). Six of 7 lagopthalmos cases occurred in a subset of 132 patients with facial patches (5%). Visual acuity scores, intra-ocular pressures and pupil cycle times were unremarkable. Bacillary invasion, keratitis, episcleritis, iridocyclitis, ectropion, synechiae, glaucoma and cataract formation were not detected. Scleral clofazimine pigmentation was frequent, resolving in most within 3 years of treatment cessation. Facial patches at presentation may denote a higher risk for lagopthalmos. We propose the generally low rates of ocular problems reflected mild lepra reactions, due to anti-inflammatory properties of clofazimine, a relatively young cohort, and a readily accessible community-based clinic permitting earlier diagnosis and prompt treatment.
C1 [Walsh, Douglas S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Ravanes, Jesus M.; Cellona, Roland V.; Balagon, Marivic; Abalos, Rodolfo M.; Walsh, Gerald P.] Leonard Wood Mem Ctr Leprosy Res, Cebu, Philippines.
RP Walsh, DS (reprint author), Armed Forces Res Inst Med Sci, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand.
EM douglas.walsh@afrims.org
FU World Health Organization; American Leprosy Missions, Greenville, South
   Carolina, USA
FX The World Health Organization and The American Leprosy Missions,
   Greenville, South Carolina, USA, provided financial support. We thank
   Paul Courtright, MD, Sundar Rao, MD, and Ebenezer Daniel, MD for
   support. Rico Abella, Mary Grace Ares, and Junie Abellana provided
   clinical assistance. Guillerma Lim and Pris Reed provided administrative
   support.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU SOUTHEAST ASIAN MINISTERS EDUC ORGANIZATION
PI BANGKOK
PA SEAMEO-TROPMED, 420-6 RAJVITHI RD,, BANGKOK 10400, THAILAND
SN 0125-1562
J9 SE ASIAN J TROP MED
JI Southeast Asian J. Trop. Med. Public Health
PD MAR
PY 2011
VL 42
IS 2
BP 323
EP 330
PG 8
WC Public, Environmental & Occupational Health; Infectious Diseases;
   Tropical Medicine
SC Public, Environmental & Occupational Health; Infectious Diseases;
   Tropical Medicine
GA 754NN
UT WOS:000289862000012
PM 21710853
ER

PT J
AU Wilken, J
   Rao, S
   Saltzman, C
   Yack, HJ
AF Wilken, Jason
   Rao, Smita
   Saltzman, Charles
   Yack, H. John
TI The effect of arch height on kinematic coupling during walking
SO CLINICAL BIOMECHANICS
LA English
DT Article
DE Arch height; Coupling; Multi-segment
ID STANCE PHASE; PLANTAR APONEUROSIS; FOOT MOTION; PES PLANUS; REAR-FOOT;
   FOREFOOT; GAIT; INJURIES; MODEL
AB The purpose of the current study was to assess kinematic coupling within the foot in individuals across a range of arch heights. Seventeen subjects participated in this study. Weight-bearing lateral radiographs were used to measure the arch height, defined as angle between the 1st metatarsal and the calcaneus. A kinematic model including the 1st metatarsal, lateral forefoot, calcaneus and tibia was used to assess foot kinematics during walking. Four coupling ratios were calculated: calcaneus frontal to forefoot transverse plane motion (Calcaneal EV/Forefoot AB), calcaneus frontal to transverse plane motion (Calcaneus EV/AB), forefoot sagittal to transverse plane motion (Forefoot DF/AB), and 1st metatarsal sagittal to transverse plane motion (1st Metatarsal DF/AB). Pearson product moment correlations were used to assess the relationship between arch height and coupling ratios. Mean (SD) radiographic arch angles of 129.8 (12.1) degrees with a range from 114 to 153 were noted, underscoring the range of arch heights in this cohort. Arch height explained approximately 3%, 38%, 12% and 1% of the variance in Calcaneal EV/Forefoot AB, Calcaneus EV/AB, Forefoot DF/AB and 1st Metatarsal DF/AB respectively. Calcaneal EV/Forefoot AB, Calcaneus EV/AB, Forefoot DF/AB and 1st Metatarsal DF/AB coupling ratios of 1.84 +/- 0.80, 0.56 +/- 0.35, 0.96 +/- 0.27 and 0.43 +/- 0.21 were noted, consistent with the twisted foot plate model, windlass mechanism and midtarsal locking mechanisms. Arch height had a small and modest relationship with kinematic coupling ratios during walking. (c) 2010 Elsevier Ltd. All rights reserved.
C1 [Rao, Smita] NYU, Dept Phys Therapy, New York, NY 10012 USA.
   [Wilken, Jason] Brooke Army Med Ctr, Ctr Intrepid, Mil Performance Lab, Ft Sam Houston, TX 78234 USA.
   [Saltzman, Charles] Univ Utah, Sch Med, Dept Orthopaed, Salt Lake City, UT USA.
   [Yack, H. John] Univ Iowa, Grad Program Phys Therapy & Rehabil Sci, Iowa City, IA USA.
RP Rao, S (reprint author), NYU, Dept Phys Therapy, 380 2nd Ave,4th Floor, New York, NY 10012 USA.
EM Smita.rao@nyu.edu
OI Wilken, Jason/0000-0002-5556-7667
NR 31
TC 11
Z9 11
U1 8
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0268-0033
EI 1879-1271
J9 CLIN BIOMECH
JI Clin. Biomech.
PD MAR
PY 2011
VL 26
IS 3
BP 318
EP 323
DI 10.1016/j.clinbiomech.2010.10.005
PG 6
WC Engineering, Biomedical; Orthopedics; Sport Sciences
SC Engineering; Orthopedics; Sport Sciences
GA 747PM
UT WOS:000289331900016
PM 21074913
ER

PT J
AU Zielinski, A
   Watt, T
   Motes, D
AF Zielinski, A.
   Watt, T.
   Motes, D.
TI Disrupting Armature Ejecta and Its Effects on Rail Damage in
   Solid-Armature Railguns
SO IEEE TRANSACTIONS ON PLASMA SCIENCE
LA English
DT Article
DE Armature ejecta; contact modifications; rail erosion; railgun
ID CONDUCTORS; COPPER
AB Material ejected from aluminum armatures at the rail-armature interface has been identified as a mechanism that degrades both rails and insulators in a railgun, significantly reducing the bore lifetime. With the goal of controlling the onset of armature ejecta, a series of single-shot tests was conducted in a small railgun with a bore cross section of 22 x 44 mm. The tests utilized channels of various sizes and geometries machined into the rail contact surface of the armatures to see if ejecta could be controlled. These tests identified several channel patterns as having the potential to delay the onset of armature ejecta. A series of multiple-shot tests was subsequently conducted in a larger railgun having a bore cross section of 38 x 76 mm. The goal of these experiments was to see if the channel patterns that delayed armature ejecta had a significant impact on rail erosion at start-up. Three test series were conducted. In the first series, three armatures with a nested circular channel pattern were tested. In the second series, three armatures with a large centrally located channel were tested. Both armature designs used equivalent contact areas. These results were then compared to a standard armature contact face with no modifications in a third test series.
C1 [Zielinski, A.] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA.
   [Watt, T.; Motes, D.] Univ Texas Austin, Inst Adv Technol, Austin, TX 78759 USA.
RP Zielinski, A (reprint author), USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM zielinsk@arl.army.mil; trevor_watt@iat.utexas.edu;
   doyle_motes@iat.utexas.edu
FU U.S. Army Research Laboratory [W911QX-07-D-0002]
FX Manuscript received April 19, 2010; revised September 10, 2010; accepted
   October 2, 2010. Date of publication January 20, 2011; date of current
   version March 9, 2011. The research reported in this paper was performed
   in connection with Contract number W911QX-07-D-0002 with the U.S. Army
   Research Laboratory. The views and conclusions contained in this paper
   are those of the authors and should not be interpreted as presenting the
   official policies or position, either expressed or implied, of the U.S.
   Army Research Laboratory or the U.S. Government unless so designated by
   other authorized documents. Citation of manufacturers or trade names
   does not constitute an official endorsement or approval of the use
   thereof. The U.S. Government is authorized to reproduce and distribute
   reprints for government purposes notwithstanding any copyright notation
   hereon.
NR 12
TC 4
Z9 5
U1 0
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0093-3813
EI 1939-9375
J9 IEEE T PLASMA SCI
JI IEEE Trans. Plasma Sci.
PD MAR
PY 2011
VL 39
IS 3
BP 941
EP 946
DI 10.1109/TPS.2010.2099241
PG 6
WC Physics, Fluids & Plasmas
SC Physics
GA 749QT
UT WOS:000289484600021
ER

PT J
AU Borowicz, DT
   Bank, LC
AF Borowicz, David T.
   Bank, Lawrence C.
TI Behavior of Pultruded Fiber-Reinforced Polymer Beams Subjected to
   Concentrated Loads in the Plane of the Web
SO JOURNAL OF COMPOSITES FOR CONSTRUCTION
LA English
DT Article
DE FRP; Pultruded beams; Concentrated loads; Shear failure; Bearing plates
ID SLENDER PLATE GIRDERS; FLANGE JUNCTIONS; FAILURE; STRENGTH; PROFILES
AB Results of the behavior of pultruded fiber-reinforced polymer (FRP) I-shaped beams subjected to concentrated loads in the plane of the web are presented. Twenty beams with nominal depths from 152.4 to 304.8 mm were tested in three-point bending with a span-to-depth ratio of four. Load was applied to the top flange directly above the web-12 without bearing plates and 8 with bearing plates of varying width and thickness. All test specimens failed with a wedgelike shear failure at the upper web-flange junction. Finite-element results support experimental findings from strain gauge and digital image correlation data. Bearing plates increased beam capacity by 35% or more as a function of bearing plate width and thickness. Bearing plates increased average shear stress in the web at failure from 17.4 to 27.2 MPa-below the accepted value of in-plane shear strength (69 MPa). A design equation is presented, and predicted capacities are compared with experimental results. The average value of experimental capacity to predicted capacity is 1.12 with a standard deviation of 0.11 and coefficient of variation (COV) of 0.10 for sections up to 304.8 mm deep. DOI: 10.1061/(ASCE)CC.1943-5614.0000082. (C) 2011 American Society of Civil Engineers.
C1 [Borowicz, David T.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
   [Borowicz, David T.; Bank, Lawrence C.] Univ Wisconsin, Dept Civil & Environm Engn, Madison, WI 53706 USA.
   [Bank, Lawrence C.] CUNY City Coll, New York, NY 10031 USA.
RP Borowicz, DT (reprint author), US Mil Acad, Dept Civil & Mech Engn, Mahan Hall 331,752 Thayer Rd, West Point, NY 10996 USA.
EM david.borowicz@usma.edu; lbank2@ccny.cuny.edu
NR 24
TC 12
Z9 12
U1 0
U2 8
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1090-0268
EI 1943-5614
J9 J COMPOS CONSTR
JI J. Compos. Constr.
PD MAR-APR
PY 2011
VL 15
IS 2
SI SI
BP 229
EP 238
DI 10.1061/(ASCE)CC.1943-5614.0000082
PG 10
WC Engineering, Civil; Mechanics; Materials Science, Composites
SC Engineering; Mechanics; Materials Science
GA 750VD
UT WOS:000289575200011
ER

PT J
AU Guda, T
   Walker, JA
   Pollot, BE
   Appleford, MR
   Oh, S
   Ong, JL
   Wenke, JC
AF Guda, Teja
   Walker, John A.
   Pollot, Beth E.
   Appleford, Mark R.
   Oh, Sunho
   Ong, Joo L.
   Wenke, Joseph C.
TI In vivo performance of bilayer hydroxyapatite scaffolds for bone tissue
   regeneration in the rabbit radius
SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
LA English
DT Article
ID CALCIUM-PHOSPHATE CERAMICS; MORPHOGENETIC PROTEIN-2; POROUS
   HYDROXYAPATITE; GRAFT SUBSTITUTES; DEFECT; MACROPOROSITY; OSTEOGENESIS;
   RESTORATION; ALLOGRAFT; AUTOGRAFT
AB The objective of this study was to investigate the in vivo biomechanical performance of bone defects implanted with novel bilayer hydroxyapatite (HAp) scaffolds that mimic the cortical and cancellous organization of bone. The scaffolds maintained architectural continuity in a rabbit radius segmental defect model and were compared to an untreated defect group (negative control) and autologous bone grafts (positive control). Micro-CT evaluations indicated total bone and scaffold volume in the experimental group was significantly greater than the defect group but lesser than the autologous bone graft treatment. The flexural toughness of the scaffold and the autograft groups was significantly greater than the flexural toughness of the defect group. Interestingly, the absolute density of the bone mineral as well as calcium to phosphorus (Ca/P) ratio in that mineral for the scaffold and autograft contralateral bones was significantly higher than those for the defect contralaterals suggesting that the scaffolds contributed to calcium homeostasis. It was concluded from this study that new bone regenerated in the bilayer HAp scaffolds was comparable to the empty defects and while the HAp scaffolds provided significant increase in modulus when compared to empty defect and their flexural toughness was comparable to autografts after 8 weeks of implantation.
C1 [Guda, Teja; Walker, John A.; Wenke, Joseph C.] USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA.
   [Guda, Teja; Pollot, Beth E.; Appleford, Mark R.; Oh, Sunho; Ong, Joo L.] Univ Texas San Antonio, Dept Biomed Engn, San Antonio, TX 78249 USA.
   [Guda, Teja] Wake Forest Univ Hlth Sci, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA.
RP Guda, T (reprint author), USA, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
EM teja.guda@gmail.com
RI Guda, Teja/A-7286-2009
OI Guda, Teja/0000-0002-3218-2916
FU Department of Defense; Orthopaedic Extremity Trauma Research Program
   [W81XWH-08-1-0393, W81XWH-07-1-0717]
FX This study was supported in part by the Department of Defense funds and
   the Orthopaedic Extremity Trauma Research Program grants (USAMRMC #
   W81XWH-08-1-0393 and W81XWH-07-1-0717). The opinions or assertions
   contained herein are the private views of the author and are not to be
   construed as official or as reflecting the views of the Department of
   the Army or the Department of Defense.
NR 29
TC 14
Z9 17
U1 2
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-4530
EI 1573-4838
J9 J MATER SCI-MATER M
JI J. Mater. Sci.-Mater. Med.
PD MAR
PY 2011
VL 22
IS 3
BP 647
EP 656
DI 10.1007/s10856-011-4241-7
PG 10
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA 747EH
UT WOS:000289302600023
PM 21287244
ER

PT J
AU Proctor, P
AF Proctor, Pat
TI MESSAGE VERSUS PERCEPTION DURING THE AMERICANIZATION OF THE VIETNAM WAR
SO HISTORIAN
LA English
DT Article
C1 [Proctor, Pat] USA, Infantry Div 1, Washington, DC 20310 USA.
RP Proctor, P (reprint author), Kansas State Univ, Manhattan, KS 66506 USA.
NR 69
TC 1
Z9 1
U1 1
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0018-2370
J9 HISTORIAN
JI Historian
PD SPR
PY 2011
VL 73
IS 1
BP 88
EP 112
DI 10.1111/j.1540-6563.2010.00287.x
PG 25
WC History
SC History
GA 732TP
UT WOS:000288212900005
ER

PT J
AU McDaniel, MA
   Psotka, J
   Legree, PJ
   Yost, AP
   Week, JA
AF McDaniel, Michael A.
   Psotka, Joseph
   Legree, Peter J.
   Yost, Amy Powell
   Week, Jeff A.
TI Toward an Understanding of Situational Judgment Item Validity and Group
   Differences
SO JOURNAL OF APPLIED PSYCHOLOGY
LA English
DT Article
DE situational judgment test; extreme responding; racial differences;
   validity
ID RESPONSE STYLES; ADVERSE IMPACT; TESTS; SELECTION
AB This paper evaluates 2 adjustments to common scoring approaches for situational judgment tests (SJTs). These adjustments can result in substantial improvements to item validity, reductions in mean racial differences, and resistance to coaching designed to improve scores. The first adjustment, applicable to SJTs that use Likert scales, controls for elevation and scatter (Cronbach & Gleser, 1953). This adjustment improves item validity. Also, because there is a White Black mean difference in the preference for extreme responses on Likert scales (Bachman & O'Malley, 1984), these adjustments substantially reduce White Black mean score differences. Furthermore, this adjustment often eliminates the score elevation associated with the coaching strategy of avoiding extreme responses (Cullen, Sackett, & Lievens, 2006). Item validity is shown to have a U-shaped relationship with item means. This holds both for SJTs with Likert score response formats and for SJTs where respondents identify the best and worst response option. Given the U-shaped relationship, the second adjustment is to drop items with midrange item means. This permits the SJT to be shortened, sometimes dramatically, without necessarily harming validity.
C1 [McDaniel, Michael A.] Virginia Commonwealth Univ, Sch Business, Richmond, VA 23284 USA.
   [Psotka, Joseph; Legree, Peter J.] USA, Res Inst Behav & Social Sci, Arlington, VA USA.
   [Yost, Amy Powell] Capital One, Tampa, FL USA.
   [Week, Jeff A.] Kenexa, Frisco, TX USA.
RP McDaniel, MA (reprint author), Virginia Commonwealth Univ, Sch Business, 301 W Main St,POB 844000, Richmond, VA 23284 USA.
EM mamcdani@vcu.edu
NR 27
TC 14
Z9 15
U1 3
U2 35
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0021-9010
J9 J APPL PSYCHOL
JI J. Appl. Psychol.
PD MAR
PY 2011
VL 96
IS 2
BP 327
EP 336
DI 10.1037/a0021983
PG 10
WC Psychology, Applied; Management
SC Psychology; Business & Economics
GA 737QX
UT WOS:000288584400008
PM 21261409
ER

PT J
AU Angie, AD
   Davis, JL
   Allen, MT
   Byrne, CL
   Ruark, GA
   Cunningham, CB
   Hoang, TS
   Bernard, DR
   Hughes, MG
   Connelly, S
   O'Hair, HD
   Mumford, MD
AF Angie, Amanda D.
   Davis, Josh L.
   Allen, Matthew T.
   Byrne, Cristina L.
   Ruark, Gregory A.
   Cunningham, Cory B.
   Hoang, Toni S.
   Bernard, Daniel R.
   Hughes, Michael G.
   Connelly, Shane
   O'Hair, H. Dan
   Mumford, Michael D.
TI Studying Ideological Groups Online: Identification and Assessment of
   Risk Factors for Violence
SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY
LA English
DT Article
ID COMPUTER-MEDIATED COMMUNICATION; SELF-ESTEEM; HATE CRIME; INTERNET;
   IDENTITY; METAANALYSIS; SKINHEADS; ANONYMITY; BEHAVIOR; BIAS
AB Recent acts of violence have demonstrated the impact of violent ideological groups worldwide. However, the systematic study of these groups is somewhat limited. The Internet is a valuable tool for investigating ideological group behavior because it is easily accessible and commonly used by these groups. This study attempted to extend previous research by examining online message boards to assess processes particular to ideological group membership. A content analysis was conducted on several group process variables using 29 groups with message boards. A Kruskal-Wallis test with follow-up pairwise comparisons was used to find that violent ideological groups differed from nonviolent ideological and nonviolent nonideological groups on 7 group process variables and 3 content variables. Implications are discussed.
C1 [Angie, Amanda D.; Davis, Josh L.; Byrne, Cristina L.; Cunningham, Cory B.; Hoang, Toni S.; Bernard, Daniel R.; Hughes, Michael G.; Connelly, Shane; O'Hair, H. Dan; Mumford, Michael D.] Univ Oklahoma, Norman, OK 73019 USA.
   [Allen, Matthew T.] Human Resources Res Org HumRRO, Alexandria, VA USA.
   [Ruark, Gregory A.] USA, Res Inst Behav & Social Sci ARI, Ft Leavenworth, KS USA.
RP Angie, AD (reprint author), 247 Tennessee Ave, Alexandria, VA 22305 USA.
EM Amanda.D.Angie@gmail.com
NR 58
TC 7
Z9 7
U1 1
U2 16
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-9029
J9 J APPL SOC PSYCHOL
JI J. Appl. Soc. Psychol.
PD MAR
PY 2011
VL 41
IS 3
BP 627
EP 657
DI 10.1111/j.1559-1816.2011.00730.x
PG 31
WC Psychology, Social
SC Psychology
GA 739HC
UT WOS:000288704400007
ER

PT J
AU Rees, DI
   Sabia, JJ
AF Rees, Daniel I.
   Sabia, Joseph J.
TI The Effect of Migraine Headache on Educational Attainment
SO JOURNAL OF HUMAN RESOURCES
LA English
DT Article
ID TENSION-TYPE HEADACHE; PROPENSITY-SCORE; UNITED-STATES; RISK-FACTORS;
   PREVALENCE; POPULATION; EPIDEMIOLOGY; BURDEN; IMPACT; LIFE
AB Despite the fact that migraine headaches are common and debilitating, little is known about their effect on educational attainment. Using data drawn from the National Longitudinal Study of Adolescent Health, we estimate the relationship between migraine headache and three outcomes: high school grade point average, the probability of graduating high school, and the probability of attending college. Our results provide evidence that migraine headache negatively impacts human capital accumulation. The relationship between migraine headache and educational attainment is explained, in part, through its effect on school absences and the respondent's self-reported ability to pay attention in class and complete homework.
C1 [Rees, Daniel I.] Univ Colorado Denver, Denver, CO 80202 USA.
   [Sabia, Joseph J.] US Mil Acad, West Point, NY 10996 USA.
RP Rees, DI (reprint author), Univ Colorado Denver, Denver, CO 80202 USA.
NR 26
TC 12
Z9 13
U1 0
U2 1
PU UNIV WISCONSIN PRESS
PI MADISON
PA JOURNAL DIVISION, 1930 MONROE ST, 3RD FL, MADISON, WI 53711 USA
SN 0022-166X
J9 J HUM RESOUR
JI J. Hum. Resour.
PD SPR
PY 2011
VL 46
IS 2
BP 317
EP 332
PG 16
WC Economics; Industrial Relations & Labor
SC Business & Economics
GA 743TB
UT WOS:000289040500004
ER

PT J
AU Do, NV
   Barnhil, R
   Heermann-Do, KA
   Salzman, KL
   Gimbel, RW
AF Do, Nhan V.
   Barnhil, Rick
   Heermann-Do, Kimberly A.
   Salzman, Keith L.
   Gimbel, Ronald W.
TI The military health system's personal health record pilot with Microsoft
   HealthVault and Google Health
SO JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
LA English
DT Article
AB Objective To design, build, implement, and evaluate a personal health record (PHR), tethered to the Military Health System, that leverages Microsoft (R) Health Vault and Google (R) Health infrastructure based on user preference.
   Materials and methods A pilot project was conducted in 2008-2009 at Madigan Army Medical Center in Tacoma, Washington. Our PHR was architected to a flexible platform that incorporated standards-based models of Continuity of Document and Continuity of Care Record to map Department of Defense-sourced health data, via a secure Veterans Administration data broker, to Microsoft (R) HealthVault and Google (R) Health based on user preference. The project design and implementation were guided by provider and patient advisory panels with formal user evaluation.
   Results The pilot project included 250 beneficiary users. Approximately 73.2% of users were <65 years of age, and 38.4% were female. Of the users, 169 (67.6%) selected Microsoft (R) HealthVault, and 81 (32.4%) selected Google (R) Health as their PHR of preference. Sample evaluation of users reflected 100% (n=60) satisfied with convenience of record access and 91.7% (n=55) satisfied with overall functionality of PHR.
   Discussion Key lessons learned related to data-transfer decisions (push vs pull), purposeful delays in reporting sensitive information, understanding and mapping PHR use and clinical workflow, and decisions on information patients may choose to share with their provider.
   Conclusion Currently PHRs are being viewed as empowering tools for patient activation. Design and implementation issues (eg, technical, organizational, information security) are substantial and must be thoughtfully approached. Adopting standards into design can enhance the national goal of portability and interoperability.
C1 [Do, Nhan V.] Walter Reed Army Med Ctr, Clin Informat Dept, Washington, DC 20307 USA.
   [Barnhil, Rick; Salzman, Keith L.] Madigan Army Med Ctr, Clin Informat Dept, Tacoma, WA 98431 USA.
   [Heermann-Do, Kimberly A.] Off Surg Gen, Off Chief Med Informat Officer, Falls Church, VA USA.
   [Gimbel, Ronald W.] Uniformed Serv Univ Hlth Sci, Biomed Informat Dept, Bethesda, MD USA.
RP Do, NV (reprint author), 5109 Leesburg Pike, Falls Church, VA 22041 USA.
EM nhan.do@us.army.mil
FU DoD; TRICARE Management Activity [02EA3TTAUJ]
FX Project funding was received from the DoD (Health Affairs) and the
   TRICARE Management Activity, project # 02EA3TTAUJ.
NR 31
TC 15
Z9 15
U1 2
U2 13
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1067-5027
J9 J AM MED INFORM ASSN
JI J. Am. Med. Inf. Assoc.
PD MAR
PY 2011
VL 18
IS 2
BP 118
EP 124
DI 10.1136/jamia.2010.004671
PG 7
WC Computer Science, Information Systems; Computer Science,
   Interdisciplinary Applications; Information Science & Library Science;
   Medical Informatics
SC Computer Science; Information Science & Library Science; Medical
   Informatics
GA 739LJ
UT WOS:000288718400004
PM 21292705
ER

PT J
AU Janelidze, N
   Jaiani, E
   Lashkhi, N
   Tskhvediani, A
   Kokashvili, T
   Gvarishvili, T
   Jgenti, D
   Mikashavidze, E
   Diasamidze, R
   Narodny, S
   Obiso, R
   Whitehouse, CA
   Huq, A
   Tediashvili, M
AF Janelidze, N.
   Jaiani, E.
   Lashkhi, N.
   Tskhvediani, A.
   Kokashvili, T.
   Gvarishvili, T.
   Jgenti, D.
   Mikashavidze, E.
   Diasamidze, R.
   Narodny, S.
   Obiso, R.
   Whitehouse, C. A.
   Huq, A.
   Tediashvili, M.
TI Microbial water quality of the Georgian coastal zone of the Black Sea
SO MARINE POLLUTION BULLETIN
LA English
DT Article
DE Water quality; Black Sea; Fecal pollution; Microbial indicators;
   Vibrios; Bacteriophage
ID FECAL INDICATOR; KEY-LARGO; GASTROENTERITIS; ECOSYSTEMS; PATHOGENS;
   POLLUTION; CHOLERA; UKRAINE; VIRUSES; FLORIDA
AB From 2006 to 2008, microbial water quality was monitored along the Georgian coast of the Black Sea. Temperature, pH, salinity, and dissolved oxygen were measured, along with a variety of aquatic microbial parameters, including heterotrophic plate count (HPC), total culturable bacterial count (TCBC), and chlorophyll a (Chl-a) concentration. Total and fecal coliforms and total enterococci counts were recorded as indicators of fecal pollution. Vibrio bacteria, and Escherichia coli- and Vibrio-specific bacteriophages were isolated and enumerated to determine their relationships to standard marine pollution indicators.
   Persistent microbial pollution was observed, particularly in the summer months, with a higher rate of contamination in estuaries. Microbial indicators generally showed seasonal dependence, suggesting that temperature may influence bacterial dynamics in this environment. No correlation was apparent between fecal pollution indicators and physical-chemical and aquatic microbial parameters, although there were significant relationships amongst the indicators themselves, as well as with the prevalence of Vibrio bacteria and phage. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Janelidze, N.; Jaiani, E.; Lashkhi, N.; Tskhvediani, A.; Kokashvili, T.; Tediashvili, M.] George Eliava Inst Bacteriophage Microbiol & Viro, GE-0160 Tbilisi, Rep of Georgia.
   [Gvarishvili, T.; Jgenti, D.; Mikashavidze, E.; Diasamidze, R.] Natl Environm Agcy Georgia, Black Sea Monitoring Inst, GE-6010 Batumi, Rep of Georgia.
   [Whitehouse, C. A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
   [Huq, A.] Univ Maryland, Maryland Pathogen Res Inst, College Pk, MD 20742 USA.
   [Narodny, S.] Bechtel Natl Corp, Frederick, MD 21703 USA.
   [Obiso, R.] Microbe Co, Christiansburg, VA 24073 USA.
RP Tediashvili, M (reprint author), George Eliava Inst Bacteriophage Microbiol & Viro, 3 Gotua St, GE-0160 Tbilisi, Rep of Georgia.
EM m_tediash.ibmv@caucasus.net
FU U.S. Defense Threat Reduction Agency [GG-13]
FX Financial support for the research was provided by the U.S. Defense
   Threat Reduction Agency under the Cooperative Biological Research
   Program project GG-13.
NR 36
TC 7
Z9 7
U1 1
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0025-326X
EI 1879-3363
J9 MAR POLLUT BULL
JI Mar. Pollut. Bull.
PD MAR
PY 2011
VL 62
IS 3
BP 573
EP 580
DI 10.1016/j.marpolbul.2010.11.027
PG 8
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA 742WZ
UT WOS:000288977300024
PM 21195436
ER

PT J
AU Murray, CPTW
AF Murray, C. P. T. William
TI Sacroiliac Joint Dysfunction A Case Study
SO ORTHOPAEDIC NURSING
LA English
DT Article
AB Pain is a widespread issue in the United States. Nine of 10 Americans regularly suffer from pain, and nearly every person will experience low back pain at one point in their lives. Undertreated or unrelieved pain costs more than $60 billion a year from decreased productivity, lost income, and medical expenses. The ability to diagnose and provide appropriate medical treatment is imperative. This case study examines a 23-year-old Active Duty woman who is preparing to be involuntarily released from military duty for an easily correctable medical condition. She has complained of chronic low back pain that radiates into her hip and down her leg since experiencing a work-related injury. She has been seen by numerous providers for the previous 11 months before being referred to the chronic pain clinic. Upon the first appointment to the chronic pain clinic, she has been diagnosed with sacroiliac joint dysfunction. This case study will demonstrate the importance of a quality lower back pain assessment.
C1 USA, Nurse Corps, Kailua, HI USA.
RP Murray, CPTW (reprint author), USA, Nurse Corps, Kailua, HI USA.
NR 8
TC 1
Z9 1
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0744-6020
J9 ORTHOP NURS
JI Orthop. Nurs.
PD MAR-APR
PY 2011
VL 30
IS 2
BP 126
EP 131
DI 10.1097/NOR.0b013e31820f513e
PG 6
WC Nursing; Orthopedics
SC Nursing; Orthopedics
GA 738PZ
UT WOS:000288655500007
ER

PT J
AU Perkins, MW
   Pierre, Z
   Rezk, P
   Song, JA
   Marshall, S
   Oguntayo, S
   Morthole, V
   Sciuto, AM
   Doctor, BP
   Nambiar, MP
AF Perkins, Michael W.
   Pierre, Zdenka
   Rezk, Peter
   Song, Jian
   Marshall, Seema
   Oguntayo, Samuel
   Morthole, Venee
   Sciuto, Alfred M.
   Doctor, Bhupendra P.
   Nambiar, Madhusoodana P.
TI Endotracheal aerosolization of atropine sulfate protects against
   soman-induced acute respiratory toxicity in guinea pigs
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Organophosphates; chemical warfare; atropine sulfate; respiratory
   toxicity; cholinesterases; neuroprotection; inhalation exposure; central
   nervous system; nerve agents
ID NONNEURONAL CHOLINERGIC SYSTEM; ACUTE LUNG INJURY; INHALATION EXPOSURE;
   ANTIOXIDANT ENZYMES; NERVE AGENTS; TISSUE CHOLINESTERASE; SEIZURE
   ACTIVITY; EFFICACY; RAT; DEPRESSION
AB The efficacy of endotracheal aerosolization of atropine sulfate for protection against soman (GD)-induced respiratory toxicity was investigated using microinstillation technique in guinea pigs. GD (841 mg/m(3), 1.3 LCt(50) or 1121 mg/m(3), 1.7 LCt(50)) was aerosolized endotracheally to anesthetized male guinea pigs that were treated with atropine sulfate (5.0 mg/kg) 30 s postexposure by endotracheal microinstillation. Animals exposed to 841 mg/m3 and 1121 mg/m(3)GD resulted in 31 and 13% while treatment with atropine sulfate resulted in 100 and 50% survival, respectively. Cholinergic symptoms and increased body weight loss were reduced in atropine-treated animals compared to GD controls. Diminished pulse rate and blood O(2) saturation in GD-exposed animals returned to normal levels after atropine treatment. Increased cell death, total cell count and protein in the bronchoalveolar fluid (BALF) in GD-exposed animals returned to normal levels following atropine treatment. GD exposure increased glutathione and superoxide dismutase levels in BALF and that were reduced in animals treated with atropine. Respiratory parameters measured by whole-body barometric plethysmography revealed that treatment with atropine sulfate resulted in normalization of respiratory frequency, tidal volume, time of expiration, time of inspiration, end expiratory pause, pseudo lung resistance (Penh) and pause at 4 and 24 h post 841 mg/m(3) GD exposure. Lung histopathology showed that atropine treatment reduced bronchial epithelial subepithelial inflammation and multifocal alveolar septal edema. These results suggest that endotracheal aerosolization of atropine sulfate protects against respiratory toxicity and lung injury induced by microinstillation inhalation exposure to lethal doses of GD.
C1 [Song, Jian; Marshall, Seema; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Closed Head Injury Branch, Silver Spring, MD 20910 USA.
   [Perkins, Michael W.; Pierre, Zdenka; Rezk, Peter; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Morthole, Venee] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA.
   [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Closed Head Injury Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Madhusoodana.Nambiar@amedd.army.mil
FU Defense Threat Reduction Agency
FX The project was supported by Defense Threat Reduction Agency. Its
   contents, opinions and assertions contained herein are private views of
   the authors and are not to be construed as official or reflecting the
   views of the Department of the Army or the Department of Defense.
NR 50
TC 3
Z9 3
U1 0
U2 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0895-8378
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD MAR
PY 2011
VL 23
IS 4
BP 182
EP 195
DI 10.3109/08958378.2011.554458
PG 14
WC Toxicology
SC Toxicology
GA 745KG
UT WOS:000289163700002
PM 21456952
ER

PT J
AU Ekimov, A
   Sabatier, JM
AF Ekimov, Alexander
   Sabatier, James M.
TI Rhythm analysis of orthogonal signals from human walking
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
AB In physical terms, periodic movements of a human body resulting from walking produce a pulse sequence with repetition time T(1) (instant cadence frequency, 1/T(1)) and duration time T(2). Footstep forces generate periodic T(1) broadband seismic and sound signals due to the dynamic forces between the foot and the ground/floor with duration time T(2), which is equal to the time interval for a single footstep from heel strike to toe slap and weight transfer. In a human gait study (for normal speeds of walking), T(1) was detected as 0.5-0.69 s and double limb support takes up about 12% of the gait cycle (2T(1)), so T(2) is greater than 0.12-0.17 s. Short range (of about 50 m) signatures for 30 humans were recorded simultaneously by four orthogonal sensor types at two locations. The sensor types were active Doppler sonar/radar and passive seismic/acoustics. Analysis of signals from these four sensors collected for walking humans showed temporal synchronization and stability of the cadence frequencies, and the cadence frequency from each sensor was equivalent. The time delay between signals from these sensors due to the differences in speeds of propagation for seismic, sound, and electromagnetic waves allows calculation of the distance from a walker to the sensor suite. (C) 2011 Acoustical Society of America. [DOI: 10.1121/1.3533694]
C1 [Ekimov, Alexander; Sabatier, James M.] Univ Mississippi, Natl Ctr Phys Acoust, University, MS 38677 USA.
   [Sabatier, James M.] USA, Army Res Lab, Adelphi, MD 20783 USA.
RP Ekimov, A (reprint author), Univ Mississippi, Natl Ctr Phys Acoust, 1 Coliseum Dr, University, MS 38677 USA.
EM aekimov@olemiss.edu
FU Department of the Army, Army Research Office [W911NF-04-1-0190,
   W911NF-08-1-0389]; Army Armament Research, Development, and Engineering
   Center [W15QKN-09-C-0163]
FX This work was supported by Department of the Army, Army Research Office
   Contracts W911NF-04-1-0190 and W911NF-08-1-0389 and Army Armament
   Research, Development, and Engineering Center Contract W15QKN-09-C-0163.
   Any opinions, findings and conclusions, or recommendations expressed in
   this material are those of the authors and do not necessarily reflect
   the views of the sponsors.
NR 20
TC 3
Z9 3
U1 0
U2 3
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD MAR
PY 2011
VL 129
IS 3
BP 1306
EP 1314
DI 10.1121/1.3533694
PG 9
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA 743GW
UT WOS:000289007000027
PM 21428494
ER

PT J
AU Gupta, N
   Ashe, PR
   Tan, SS
AF Gupta, Neelam
   Ashe, Philip R.
   Tan, Songsheng
TI Miniature snapshot multispectral imager
SO OPTICAL ENGINEERING
LA English
DT Article
DE snapshot; multispectral; Fabry-Perot filter; Bragg stack mirrors;
   shortwave infrared; indium gallium arsenide focal plane array;
   micro-optic assembly
ID SPECTROMETER; FABRICATION; MIRRORS
AB We present a miniature snapshot multispectral imager based on using a monolithic filter array that operates in the short wavelength infrared spectral region and has a number of defense and commercial applications. The system is low-weight, portable with a miniature platform, and requires low power. The imager uses a 4x4 Fabry-Perot filter array operating from 1487 to 1769 nm with a spectral bandpass similar to 10 nm. The design of the filters is based on using a shadow mask technique to fabricate an array of Fabry-Perot etalons with two multilayer dielectric mirrors. The filter array is installed in a commercial handheld InGaAs camera, replacing the imaging lens with a custom designed 4x4 microlens assembly with telecentric imaging performance in each of the 16 subimaging channels. We imaged several indoor and outdoor scenes. The microlens assembly and filter design is quite flexible and can be tailored for any wavelength region from the ultraviolet to the longwave infrared, and the spectral bandpass can also be customized to meet sensing requirements. In this paper we discuss the design and characterization of the filter array, the microlens optical assembly, and imager and present imaging results. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3552665]
C1 [Gupta, Neelam] USA, Res Lab, Adelphi, MD 20783 USA.
   [Ashe, Philip R.; Tan, Songsheng] Smart Syst Technol & Commercializat Ctr, Canandaigua, NY 14424 USA.
RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM neelam.gupta@us.army.mil
RI Gupta, Neelam/B-8702-2013
NR 14
TC 7
Z9 7
U1 1
U2 13
PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 0091-3286
J9 OPT ENG
JI Opt. Eng.
PD MAR
PY 2011
VL 50
IS 3
AR 033203
DI 10.1117/1.3552665
PG 9
WC Optics
SC Optics
GA 742KW
UT WOS:000288943200008
ER

PT J
AU Endy, TP
   Anderson, KB
   Nisalak, A
   Yoon, IK
   Green, S
   Rothman, AL
   Thomas, SJ
   Jarman, RG
   Libraty, DH
   Gibbons, RV
AF Endy, Timothy P.
   Anderson, Kathryn B.
   Nisalak, Ananda
   Yoon, In-Kyu
   Green, Sharone
   Rothman, Alan L.
   Thomas, Stephen J.
   Jarman, Richard G.
   Libraty, Daniel H.
   Gibbons, Robert V.
TI Determinants of Inapparent and Symptomatic Dengue Infection in a
   Prospective Study of Primary School Children in Kamphaeng Phet, Thailand
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER; VIRUS-INFECTION; DISEASE; IDENTIFICATION;
   EPIDEMIOLOGY; CIRCULATION; BANGKOK; COHORT; ASSAY
AB Background: Dengue viruses are a major cause of morbidity in tropical and subtropical regions of the world. Inapparent dengue is an important component of the overall burden of dengue infection. It provides a source of infection for mosquito transmission during the course of an epidemic, yet by definition is undetected by health care providers. Previous studies of inapparent or subclinical infection have reported varying ratios of symptomatic to inapparent dengue infection.
   Methodology/Principal Findings: In a prospective study of school children in Northern Thailand, we describe the spatial and temporal variation of the symptomatic to inapparent (S:I) dengue illness ratio. Our findings indicate that there is a wide fluctuation in this ratio between and among schools in a given year and within schools over several dengue seasons. The most important determinants of this S:I ratio for a given school were the incidence of dengue infection in a given year and the incidence of infection in the preceding year. We found no association between the S:I ratio and age in our population.
   Conclusions/Significance: Our findings point to an important aspect of virus-host interactions at either a population or individual level possibly due to an effect of heterotypic cross-reactive immunity to reduce dengue disease severity. These findings have important implications for future dengue vaccines.
C1 [Endy, Timothy P.] SUNY Syracuse, Div Infect Dis, Upstate Med Univ, Syracuse, NY USA.
   [Anderson, Kathryn B.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Nisalak, Ananda; Yoon, In-Kyu; Thomas, Stephen J.; Jarman, Richard G.; Gibbons, Robert V.] US Army Med Component, Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand.
   [Green, Sharone; Rothman, Alan L.; Libraty, Daniel H.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA.
RP Endy, TP (reprint author), SUNY Syracuse, Div Infect Dis, Upstate Med Univ, Syracuse, NY USA.
EM endyt@upstate.edu
FU National Institutes of Health (NIH) [P01 AI34533]; United States Army
   Medical Research and Materiel Command, Ft. Detrick, MD
FX This project and publication was made possible by National Institutes of
   Health (NIH) Grant P01 AI34533 and the United States Army Medical
   Research and Materiel Command, Ft. Detrick, MD. The funders had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 21
TC 83
Z9 86
U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAR
PY 2011
VL 5
IS 3
AR e975
DI 10.1371/journal.pntd.0000975
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 742KI
UT WOS:000288940800009
PM 21390158
ER

PT J
AU Wichmann, O
   Yoon, IK
   Vong, S
   Limkittikul, K
   Gibbons, RV
   Mammen, MP
   Ly, S
   Buchy, P
   Sirivichayakul, C
   Buathong, R
   Huy, R
   Letson, GW
   Sabchareon, A
AF Wichmann, Ole
   Yoon, In-Kyu
   Vong, Sirenda
   Limkittikul, Kriengsak
   Gibbons, Robert V.
   Mammen, Mammen P.
   Ly, Sowath
   Buchy, Philippe
   Sirivichayakul, Chukiat
   Buathong, Rome
   Huy, Rekol
   Letson, G. William
   Sabchareon, Arunee
TI Dengue in Thailand and Cambodia: An Assessment of the Degree of
   Underrecognized Disease Burden Based on Reported Cases
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID ADJUSTED LIFE YEARS; PUERTO-RICO; SURVEILLANCE; CHILDREN; INFECTIONS
AB Background: Disease incidence data are needed to guide decision-making for public health interventions. Although dengue is a reportable disease in Thailand and Cambodia, the degree that reported incidence underrecognizes true disease burden is unknown. We utilized dengue incidence calculated from laboratory-confirmed outpatient and inpatient cases in prospective cohort studies to estimate the magnitude of dengue underrecognition and to establish more accurate disease burden estimates for these countries.
   Methods and Findings: Cohort studies were conducted among children aged < 15 years by members of a dengue field site consortium over at least 2 dengue seasons. Age-group specific multiplication factors (MFs) were computed by comparing data from three cohort studies to national surveillance data in the same province and year. In Thailand, 14,627 person-years of prospective cohort data were obtained in two provinces and 14,493 person-years from one province in Cambodia. Average annual incidence of laboratory-confirmed dengue was 23/1,000 and 25/1,000 in Thailand, and 41/1,000 in Cambodia. Calculated MFs in these provinces varied by age-group and year (range 0.4-29). Average age-group specific MFs were then applied to country-level reporting data and indicated that in Thailand a median 229,886 (range 210,612-331,236) dengue cases occurred annually during 2003-2007 and a median 111,178 (range 80,452-357,135) cases occurred in Cambodia in children < 15 years of age. Average underrecognition of total and inpatient dengue cases was 8.7 and 2.6-fold in Thailand, and 9.1 and 1.4-fold in Cambodia, respectively. During the high-incidence year 2007, > 95,000 children in Thailand and > 58,000 children in Cambodia were estimated to be hospitalized due to dengue.
   Conclusion: Calculating MFs by comparing prospective cohort study data to locally-reported national surveillance data is one approach to more accurately assess disease burden. These data indicate that although dengue is regularly reported in many countries, national surveillance data significantly underrecognize the true burden of disease.
C1 [Wichmann, Ole; Letson, G. William] Int Vaccine Inst, Pediat Dengue Vaccine Initiat, Seoul, South Korea.
   [Yoon, In-Kyu; Gibbons, Robert V.; Mammen, Mammen P.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Vong, Sirenda; Ly, Sowath; Buchy, Philippe] Inst Pasteur Cambodia, Phnom Penh, Cambodia.
   [Limkittikul, Kriengsak; Sirivichayakul, Chukiat; Sabchareon, Arunee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
   [Buathong, Rome] Minist Publ Hlth, Bur Epidemiol, Nonthaburi, Thailand.
   [Huy, Rekol] Minist Hlth, Natl Dengue Control Program, Phnom Penh, Cambodia.
RP Wichmann, O (reprint author), Int Vaccine Inst, Pediat Dengue Vaccine Initiat, Seoul, South Korea.
EM WichmannO@rki.de
OI Wichmann, Ole/0000-0003-2353-7188
FU Bill and Melinda Gates Foundation [23197]; National Institutes of Health
   [P01-AI034533]; Military Infectious Diseases Research Program (MIDRP)
   [S0016_04_AF]; PDVI; Thai Ministry of Public Health; KOICA (Korea
   International Cooperation Agency); Provincial Public Health Offices in
   Kamphaeng Phet; Provincial Public Health Offices in Ratchaburi;
   Provincial Public Health Offices in Kampong Cham
FX The Pediatric Dengue Vaccine Initiative (PDVI) received funds from the
   Bill and Melinda Gates Foundation (grant number 23197). The Kamphaeng
   Phet study was supported by funds from the National Institutes of Health
   (grant number P01-AI034533) and the Military Infectious Diseases
   Research Program (MIDRP) (grant number S0016_04_AF), the Ratchaburi
   study was supported by funds from PDVI and the Thai Ministry of Public
   Health, and the Kampong Cham study received funds from PDVI and KOICA
   (Korea International Cooperation Agency). Except PDVI, the funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.; The authors thank all field,
   department, and laboratory staff who performed the case surveillance,
   data collection, data entry and diagnostic testing for the cohort
   studies. They also acknowledge the support of the Provincial Public
   Health Offices in Kamphaeng Phet, in Ratchaburi, and in Kampong Cham.
NR 28
TC 38
Z9 38
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1935-2727
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD MAR
PY 2011
VL 5
IS 3
AR e996
DI 10.1371/journal.pntd.0000996
PG 9
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 742KI
UT WOS:000288940800027
PM 21468308
ER

PT J
AU Leggit, JC
AF Leggit, Jeffrey C.
TI Evaluation and Treatment of GERD and Upper GI Complaints in Athletes
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID GASTROESOPHAGEAL-REFLUX DISEASE; PLACEBO-CONTROLLED TRIAL; PROTON PUMP
   INHIBITORS; ESOPHAGEAL DISORDERS; ACID REFLUX; MANAGEMENT; THERAPY;
   ASTHMA; RISK; GUIDELINES
AB Athletes are susceptible to upper gastrointestinal complaints just like the general population. The most common etiologies are gastroesophageal reflux disease (GERD) and functional heartburn. If the signs and symptoms are compatible with GERD and the clinician has considered more serious pathology unlikely, a therapeutic trial with a proton pump inhibitor (PPI) can be initiated without further evaluation. The treatment for pure exertional GERD is similar but is guided by expert opinion only. Surgery has a limited role, but new techniques are evolving that may change the risk-to-benefit ratio. Chronic PPI therapy generally is safe, but there is a small risk of osteoporosis with concomitant fracture. There is no evidence for routine endoscopic screening for Barrett's esophagus or esophageal adenocarcinoma. For those who do not respond to treatment, the most likely diagnosis is functional heartburn. This is a diagnosis of exclusion, and referral to gastroenterology is warranted for diagnostic testing.
C1 USA, Med Corps, Frederick, MD 21704 USA.
RP Leggit, JC (reprint author), USA, Med Corps, 9706 Ethan Ridge Ave, Frederick, MD 21704 USA.
EM Jeffrey.c.leggit@us.army.mil
NR 35
TC 0
Z9 0
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1537-890X
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD MAR-APR
PY 2011
VL 10
IS 2
BP 109
EP 114
DI 10.1249/JSR.0b013e31820f31ca
PG 6
WC Sport Sciences
SC Sport Sciences
GA 736YP
UT WOS:000288531300011
PM 21623293
ER

PT J
AU Shurtleff, AC
   Warren, TK
   Bavari, S
AF Shurtleff, Amy C.
   Warren, Travis K.
   Bavari, Sina
TI Nonhuman primates as models for the discovery and development of
   ebolavirus therapeutics
SO EXPERT OPINION ON DRUG DISCOVERY
LA English
DT Review
DE animal model; antiviral; cynomolgus; ebolavirus; FDA Animal Efficacy
   rule; filoviruses; hemorrhagic fever; in vivo; nonhuman primate;
   prophylaxis; rhesus; therapeutics; therapy; treatment
ID VIRUS-INFECTED PATIENTS; HEMORRHAGIC-FEVER; RHESUS-MONKEYS; DENDRITIC
   CELLS; POSTEXPOSURE PROTECTION; MORPHOLINO OLIGOMERS; MARBURG VIRUSES;
   FILOVIRUS INFECTIONS; CYNOMOLGUS MACAQUES; IMMUNE-RESPONSES
AB Introduction: Ebolaviruses are human pathogenic Category A priority pathogens for which no vaccines or therapeutics are currently licensed; however, several therapeutic agents have shown promising efficacy in nonhuman primate models of infection and are potential candidates for use in humans. Demonstration of efficacy in nonhuman primate models of ebolavirus infection will probably be central to the development and eventual licensure of ebolavirus medical countermeasures given the ethical and feasibility constraints of human efficacy assessments.
   Areas covered: The authors describe ebolavirus hemorrhagic fever (EHF), with an emphasis on comparing human and nonhuman primate pathophysiology. Published data examining human and animal clinical disease parameters, histopathological findings, and immune responses in fatal and nonfatal cases are synthesized and evaluated. Importantly, the authors also introduce and describe the FDA Animal Efficacy Rule as well as recent advances in antiviral drug development strategies for the treatment of EHF.
   Expert opinion: Well-characterized models of ebolavirus infection are currently under development and scrutiny as to their accuracy and utility for modeling fatal infection in humans. The advanced development and eventual licensure of therapeutic agents will require demonstration that mechanisms conferring protection in nonhuman primate models of infection are predictive of protective responses in humans.
C1 [Shurtleff, Amy C.; Warren, Travis K.; Bavari, Sina] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD 21702 USA.
RP Bavari, S (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Frederick, MD 21702 USA.
EM sina.bavari@us.army.mil
FU US Defense Threat Reduction Agency [1.1C003_08_RD_B]; Transformational
   Medical Technologies [TMTIO048_09_RD_T]
FX Support for filovirus evaluations has been provided by the US Defense
   Threat Reduction Agency (1.1C003_08_RD_B) and by Transformational
   Medical Technologies (TMTIO048_09_RD_T). S Bavari claims intellectual
   property regarding PMOs for the treatment of filovirus infections.
NR 100
TC 13
Z9 13
U1 0
U2 2
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1746-0441
EI 1746-045X
J9 EXPERT OPIN DRUG DIS
JI Expert. Opin. Drug Discov.
PD MAR
PY 2011
VL 6
IS 3
BP 233
EP 250
DI 10.1517/17460441.2011.554815
PG 18
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 738MR
UT WOS:000288644400003
PM 22647202
ER

PT J
AU Darwish, AM
   Hung, HA
AF Darwish, Ali M.
   Hung, H. Alfred
TI Improving Thermal Reliability of FETs and MMICs
SO IEEE TRANSACTIONS ON DEVICE AND MATERIALS RELIABILITY
LA English
DT Article
DE Integrated circuit reliability; monolithic microwave integrated circuit
   (MMIC) reliability; semiconductor device reliability; thermal resistance
ID GAASPHEMTS; DEGRADATION; TRANSISTORS; RESISTANCE; STRESS
AB The constant need for higher speed leads to the requirement of field effect transistors (FETs) with shorter gate lengths, smaller gate widths, and narrower gate-finger pitches. The relationship between various FET parameters and the device lifetime is not readily determined due to the complexity of the problem, along with the elaborate, time-consuming process, and expense of the measurements to establish reliability. This paper presents analytical expressions relating FET reliability [the change in the mean-time-to-failure (MTTF)] to its gate length, width, pitch, substrate thickness, thermal conductivity, and dissipated power. Experimental observations support the model's conclusions. The expressions and results are useful to device/circuit designers to assess the projected MTTF value in their device/MMIC designs.
C1 [Darwish, Ali M.; Hung, H. Alfred] USA, Res Lab, Adelphi, MD 20783 USA.
RP Darwish, AM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM darwish@alum.mit.edu; hahung@alum.mit.edu
NR 29
TC 4
Z9 4
U1 1
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1530-4388
J9 IEEE T DEVICE MAT RE
JI IEEE Trans. Device Mater. Reliab.
PD MAR
PY 2011
VL 11
IS 1
BP 164
EP 170
DI 10.1109/TDMR.2010.2102024
PG 7
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA 735XT
UT WOS:000288454700024
ER

PT J
AU Darwish, AM
   Hung, HA
   Bayba, AJ
   El-Kinawi, K
AF Darwish, Ali M.
   Hung, H. Alfred
   Bayba, Andrew J.
   El-Kinawi, Khaled
TI Accurate Calculation of Junction Temperature of HBTs
SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
LA English
DT Article
DE Heterojunction bipolar transistors (HBTs); reliability; thermal
   resistance
ID THERMAL-RESISTANCE; BIPOLAR-TRANSISTORS; DEVICES
AB Heterojunction bipolar transistors (HBTs) offer high power and linearity for microwave and mixed-signal applications. The large-signal performance of an HBT is frequently limited by the maximum operating current, which is set by thermal considerations. Hence, an accurate determination of the junction temperature in HBT devices and the corresponding microwave/millimeter-wave monolithic integrated circuits (MMICs)/DAC is critical to achieving maximum performance while maintaining reliable operation. An original accurate closed-form expression is presented for the thermal resistance of HBT structures from which the maximum junction temperature can be determined. The model's validity is verified by numerical simulations and experimental data. The model agrees with two sets of experimental data to within 2% and 6%. The closed-form solution offers device and MMIC designers a fast assessment of the performance and reliability of devices and circuits. Circuit optimization for required performance can be achieved efficiently.
C1 [Darwish, Ali M.; Hung, H. Alfred; Bayba, Andrew J.] USA, Res Lab, Adelphi, MD 20783 USA.
   [Darwish, Ali M.; El-Kinawi, Khaled] Amer Univ Cairo, Dept Elect Engn, New Cairo 11835, Egypt.
RP Darwish, AM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM darwish@alum.mit.edu; hahung@alum.mit.edu; an-drew.j.bayba@us.army.mil;
   khaled.kinawi@gmail.com
NR 30
TC 4
Z9 4
U1 0
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9480
J9 IEEE T MICROW THEORY
JI IEEE Trans. Microw. Theory Tech.
PD MAR
PY 2011
VL 59
IS 3
BP 652
EP 659
DI 10.1109/TMTT.2010.2103231
PG 8
WC Engineering, Electrical & Electronic
SC Engineering
GA 735ZY
UT WOS:000288460500017
ER

PT J
AU Newhouse, RP
   Morlock, L
   Pronovost, P
   Sproat, SB
AF Newhouse, Robin P.
   Morlock, Laura
   Pronovost, Peter
   Sproat, Sara Breckenridge
TI Rural Hospital Nursing Results of a National Survey of Nurse Executives
SO JOURNAL OF NURSING ADMINISTRATION
LA English
DT Article
ID UNITED-STATES; QUALITY; IMPLEMENTATION
AB Objective: The objective of the study was to describe nursing characteristics in small and larger rural hospitals and determine whether differences exist in market, hospital, and nursing characteristics.
   Background: A better description of nursing in rural settings is needed to understand the work context.
   Methods: A national sample of rural hospital nurse executives (n = 280) completed the Nurse Environment Survey and Essentials of Magnetism instrument.
   Results: Larger rural hospitals are more likely than small hospitals to have a clinical ladder (32.4% vs 19.4%), more baccalaureate-prepared RNs (20.8% vs 17.1%), greater perceived economic (mean, 9.5 vs 8.5) and external influences (mean, 41.1 vs 39.8), lower shared vision among hospital staff (mean, 18.4 vs 19.4), and higher levels of quality and safety engagement (mean, 16.9 vs 16.1). Most nurses employed in rural hospitals are educated at the associate degree (77.4%) level.
   Conclusions: Contextual differences exist between small and larger rural hospitals. To promote the best patient outcomes, attention to contextual differences is needed to tailor nursing interventions to fit the resources, environment, and patient needs in a given healthcare setting.
C1 [Newhouse, Robin P.] Univ Maryland, Sch Nursing, Doctor Nursing Practice Program, Baltimore, MD 21201 USA.
   [Morlock, Laura] Johns Hopkins Univ, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, Baltimore, MD 21218 USA.
   [Pronovost, Peter] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Ctr Innovat Qual Patient Care, Baltimore, MD 21205 USA.
   [Sproat, Sara Breckenridge] US Army Nurse Corps, Walter Reed Army Med Ctr, Washington, DC USA.
RP Newhouse, RP (reprint author), Univ Maryland, Sch Nursing, Doctor Nursing Practice Program, 655 W Lombard St,Suite 516B, Baltimore, MD 21201 USA.
EM newhouse@son.umaryland.edu
FU Agency for Healthcare Research and Quality [KO8HS015548]
FX This study was supported by grant KO8HS015548 from the Agency for
   Healthcare Research and Quality.
NR 34
TC 9
Z9 9
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0002-0443
J9 J NURS ADMIN
JI J. Nurs. Adm.
PD MAR
PY 2011
VL 41
IS 3
BP 129
EP 137
DI 10.1097/NNA.0b013e31820c7212
PG 9
WC Nursing
SC Nursing
GA 723AV
UT WOS:000287479300007
PM 21336041
ER

PT J
AU Chappell, MG
   Koeller, CA
   Hall, SI
AF Chappell, Mark G.
   Koeller, Craig A.
   Hall, Shannan I.
TI Differences in Postsurgical Recovery of CF1 Mice after Intraperitoneal
   Implantation of Radiotelemetry Devices through a Mid line or Flank
   Surgical Approach
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID SMALL LABORATORY-ANIMALS; BODY-TEMPERATURE; TRANSMITTER IMPLANTATION;
   POSTOPERATIVE RECOVERY; TELEMETRY; OVARIOHYSTERECTOMY; REFINEMENT;
   ANALGESIA; IMPACT; MODEL
AB Minimizing the pain or discomfort of research animals through refinement of surgical techniques is inherent in the humane use of animals in investigative studies. The current approach for intraperitoneal implantation of radiotelemetry devices in mice is a ventral midline incision. An optional surgical approach is a flank incision. We used multidimensional analysis to compare midline and flank approaches for implantation of radiotelemetry devices in regard to time of surgery, activity, temperature, food intake, gel intake, body weight, and vitality scores. A third group was used to evaluate the effects of buprenorphine in healthy mice. The study demonstrated positive benefits related to the flank approach, including quicker surgery times, improved activity levels, more stable temperature homeostasis, smaller losses in body weight, and quicker return to presurgical baseline levels of food intake. In addition, direct effects of buprenorphine included decreases in food intake and body weight, with the effects on body weight lasting approximately 8 d after treatment. Collectively, these results suggest that implantation of intraperitoneal radiotelemetry devices by using a flank approach is beneficial to mice.
C1 [Chappell, Mark G.; Koeller, Craig A.; Hall, Shannan I.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Chappell, MG (reprint author), USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM mark.chappell@us.army.mil
NR 33
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U1 0
U2 2
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD MAR
PY 2011
VL 50
IS 2
BP 227
EP 237
PG 11
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA 738MJ
UT WOS:000288643600011
PM 21439217
ER

PT J
AU Hakre, S
   Peel, SA
   O'Connell, RJ
   Sanders-Buell, EE
   Jagodzinski, LL
   Eggleston, JC
   Myles, O
   Waterman, PE
   McBride, RH
   Eader, SA
   Davis, KW
   Rentas, FJ
   Sateren, WB
   Naito, NA
   Tobler, SK
   Tovanabutra, S
   Petruccelli, BP
   McCutchan, FE
   Michael, NL
   Cersovsky, SB
   Scott, PT
AF Hakre, Shilpa
   Peel, Sheila A.
   O'Connell, Robert J.
   Sanders-Buell, Eric E.
   Jagodzinski, Linda L.
   Eggleston, John C.
   Myles, Otha
   Waterman, Paige E.
   McBride, Richard H.
   Eader, Scott A.
   Davis, Kenneth W.
   Rentas, Francisco J.
   Sateren, Warren B.
   Naito, Neal A.
   Tobler, Steven K.
   Tovanabutra, Sodsai
   Petruccelli, Bruno P.
   McCutchan, Francine E.
   Michael, Nelson L.
   Cersovsky, Steven B.
   Scott, Paul T.
TI Transfusion-transmissible viral infections among US military recipients
   of whole blood and platelets during Operation Enduring Freedom and
   Operation Iraqi Freedom
SO TRANSFUSION
LA English
DT Article
ID HEPATITIS-C VIRUS; PREVALENCE; SYSTEM; WAR
AB BACKGROUND: Current US military clinical practice guidelines permit emergency transfusions of non-Food and Drug Administration (FDA)-compliant freshly collected blood products in theaters of war. This investigation aimed to characterize the risks of transfusion-transmitted infections (TTIs) associated with battlefield transfusions of non-FDA-compliant blood products.
   STUDY DESIGN AND METHODS: US Service members who received emergency transfusion products in Iraq and Afghanistan (March 1, 2002-September 30, 2007) were tested for hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) infections using reposed pre- and posttransfusion sera. Selected regions of viral genomes from epidemiologically linked infected recipients and their donors were sequenced and compared.
   RESULTS: Of 761 US Service members who received emergency transfusion products, 475 were tested for HCV, 472 for HIV, and 469 for HBV. One transfusion-transmitted HCV infection (incidence rate of 2.1/1000 persons) was identified. The pretransfusion numbers (prevalence per 1000 persons) were HCV-four (8/1000), HIV-zero (0/1000), chronic HBV-two (4/1000), and naturally immune (antibody to HBV core antigen)-nine (19/1000).
   CONCLUSION: One HCV TTI was determined to be associated with emergency blood product use. The pretransfusion HCV and HBV prevalence in transfusion recipients, themselves members of the potential donor population, indicates better characterization of the deployed force's actual donor population, and further investigations of the TTI prevalence in these donors are needed. These data will inform countermeasure development and clinical decision making.
C1 Armed Serv Blood Program Off, Falls Church, VA USA.
   USA, Blood Program, Falls Church, VA USA.
   USN, Bur Med & Surg, Washington, DC USA.
   US Cent Command, Joint Blood Program Off, Tampa, FL USA.
   [Hakre, Shilpa] Henry M Jackson Fdn Advancement Mil Med, US Mil HIV Res Program, Rockville, MD 20850 USA.
   US Publ Hlth Command Provis, Aberdeen Proving Ground, MD USA.
   US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Hakre, S (reprint author), Henry M Jackson Fdn Advancement Mil Med, US Mil HIV Res Program, 1 Taft Court,Suite 100, Rockville, MD 20850 USA.
EM shakre@hivresearch.org
FU United States Public Health Command (Provisional), formerly the United
   States Army Center for Health Promotion and Preventive Medicine
FX This work was supported by funds from the United States Public Health
   Command (Provisional), formerly the United States Army Center for Health
   Promotion and Preventive Medicine.
NR 22
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U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD MAR
PY 2011
VL 51
IS 3
BP 473
EP 485
DI 10.1111/j.1537-2995.2010.02906.x
PG 13
WC Hematology
SC Hematology
GA 732DZ
UT WOS:000288166200007
PM 20946199
ER

PT J
AU Lotufo, GR
AF Lotufo, Guilherme R.
TI Whole-body and body-part-specific bioconcentration of explosive
   compounds in sheepshead minnows
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Explosives; TNT; RDX; TNT; Bioconcentration; Sheepshead minnow;
   Cyprinodon variegatus
ID CATFISH ICTALURUS-PUNCTATUS; TISSUE DISTRIBUTION; TRINITROTOLUENE TNT;
   AQUATIC ORGANISMS; COVALENT BINDING; ACCUMULATION;
   2,4,6-TRINITROTOLUENE; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE;
   TOXICITY; FISH
AB Sheepshead minnows (Cyprinodon variegatus) were exposed to radiolabeled isotopes of the explosives 2,4,6-trinitrotoluene (TNT), exahydro-1,3,5-trinitro-1,3,5-triazine (commonly known as RDX), and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (commonly known as HMX), yielding the bioconcentration factors (BCF) of 3.3, 0.7, and 0.1 L kg(-1), respectively. For TNT, the body residue of transformation product exceeded that of the parent compound by factors of 1, 8, and 16 for total aminonitrotoluenes, total extractable compounds, and total transformation products, respectively, with substantial bioaccumulation of both non-identified extractable and unextractable (i.e., tissue-bound), compounds. In comparison, the sum body residues of RDX and HMX transformation products were < 4 times higher than for parent compounds. The concentrations of RDX and HMX and their transformation products were similar among liver, viscera (excluding liver), gills, and body remains (integument and muscles), while 46% of the TNT transformation products resided in the liver, and 64% of the parent compound was in the viscera. Published by Elsevier Inc.
C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Lotufo, GR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM guilherme.lotufo@usace.army.mil
FU US Navy; U.S. Army
FX The US Navy's Environmental Sustainability Development to Integration
   Program and the Environmental Quality Technology Research Program of the
   U.S. Army supported this research. Permission to publish this study was
   granted by the Chief of Naval Operations (N456) and the Chief of
   Engineers. The authors thank Daniel Farrar for high performance liquid
   chromatography analyses. We are grateful to Gunther Rosen, Alan Kennedy,
   and M. John Cullinane and Elizabeth Ferguson for their review of this
   manuscript.
NR 25
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U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD MAR
PY 2011
VL 74
IS 3
BP 301
EP 306
DI 10.1016/j.ecoenv.2010.07.039
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 732YX
UT WOS:000288226700013
PM 21255837
ER

PT J
AU Laczek, J
   Flasar, M
   Goldberg, E
   Darwin, P
AF Laczek, Jeffrey
   Flasar, Mark
   Goldberg, Eric
   Darwin, Peter
TI Contrast Does Not Affect Cholangioscope Image Quality
SO GUT AND LIVER
LA English
DT Article
DE Bile ducts; Endoscopes; Cholangiopancreatography; Endoscopic retrograde
AB Background/Aims: Peroral cholangioscopy is a rapidly evolving technique that allows direct examination of the bile duct. We sought to determine if there was a difference in image quality with the cholangioscope immersed in normal saline compared with radiologic contrast or a mixture of contrast and normal saline. Methods: Images were captured using the SpyGlase (R) cholangioscope system (Boston Scientific Corp.) immersed in solutions ranging from 0 to 100% contrast. The images were then reviewed in a blinded fashion by a panel of 9 endoscopists with experience using the SpyGlase (R) system. The reviewers scored the quality of each image based on a scale of 0 (extremely poor) to 10 (excellent). Results: With the cholangioscope immersed in saline and 100% contrast, the mean image quality scores were 7.6 (95% confidence interval [CI], 6.7-8.5) and 6.9 (95% CI, 5.8-8.0), respectively. The highest mean image quality score was 7.8 (95% CI, 6.7-8.9), obtained in 70% contrast. No significant difference was noted in mean image quality scores using a one way analysis of variance technique (p=0.414). Conclusions: Although there are limitations to ex vivo studies, we encourage endoscopists to use intraductal contrast prior to peroral cholangioscopy, if needed for lesion localization. (Gut Liver 2011;5:115-116)
C1 [Laczek, Jeffrey] Walter Reed Army Med Ctr, Div Gastroenterol, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA.
   [Flasar, Mark; Goldberg, Eric; Darwin, Peter] Univ Maryland, Div Gastroenterol, Med Ctr, Baltimore, MD 21201 USA.
RP Laczek, J (reprint author), Walter Reed Army Med Ctr, Div Gastroenterol, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA.
EM Jeffrey.laczek@us.army.mil
FU schurrer family funds
FX Financial assistance was provided by the schurrer family funds.
NR 2
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U1 0
U2 0
PU EDITORIAL OFFICE GUT & LIVER
PI SEOUL
PA 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL,
   135-839, SOUTH KOREA
SN 1976-2283
J9 GUT LIVER
JI Gut Liver
PD MAR
PY 2011
VL 5
IS 1
BP 115
EP 116
DI 10.5009/gnl.2011.5.1.115
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA 737LG
UT WOS:000288569700020
PM 21461085
ER

PT J
AU Duarte, FJ
   Taylor, TS
   Black, AM
   Davenport, WE
   Varmette, PG
AF Duarte, F. J.
   Taylor, T. S.
   Black, A. M.
   Davenport, W. E.
   Varmette, P. G.
TI N-slit interferometer for secure free-space optical communications: 527
   m intra interferometric path length
SO JOURNAL OF OPTICS
LA English
DT Article
DE aviation; beam expansion; clear air turbulence; Dirac notation;
   free-space; propagation; interferometric character; interferometric
   imaging; N-slit interference; N-slit interferometer; N-slit
   interferometry; natural fibers
ID INTERFERENCE; REFRACTION
AB The N-slit interferometer is demonstrated to function with an intra interferometric propagation path length of 527.33 m. Interferograms representing several interferometric characters, corresponding to N = 2, 3, 4, and 5, were recorded at the interferometric plane located at the end of an open air propagation range. Interferometric computations, based on the application of Dirac's notation, were successfully used to predict the structure and divergence of the propagating interferograms. These measurements were carried out during an unusual mild-temperature, low-humidity, summer night in northern Alabama. In the laboratory, at an intra interferometric propagation path length of 7.235 m, the N-slit interferometer was also used to successfully detect the intrusion of microscopic fibers into the intra interferometric propagation path. These experiments led to the detection of diffraction patterns superimposed over the interferograms.
C1 [Duarte, F. J.] Interferometr Opt, Rochester, NY 14626 USA.
   [Duarte, F. J.] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
   [Taylor, T. S.; Black, A. M.] USA, Space & Missile Def Command, Ctr Tech, Technol Directorate,Directed Energy Div, Huntsville, AL 35807 USA.
   [Davenport, W. E.] USA, Aviat & Missile Command, Weap Sci Directorate, Redstone Arsenal, AL 35898 USA.
   [Varmette, P. G.] Sci Applicat Int Corp, Huntsville, AL 35806 USA.
RP Duarte, FJ (reprint author), Interferometr Opt, Rochester, NY 14626 USA.
FU US Army High Energy Laser Laboratory
FX This a US Army High Energy Laser Laboratory project funded through a
   subcontract to BAE Systems.
NR 13
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U1 1
U2 6
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 2040-8978
J9 J OPT-UK
JI J. Opt.
PD MAR
PY 2011
VL 13
IS 3
AR 035710
DI 10.1088/2040-8978/13/3/035710
PG 5
WC Optics
SC Optics
GA 737VT
UT WOS:000288598100032
ER

PT J
AU Chang, WW
   Hromadka, TV
   Chang, HH
AF Chang, Wayne W.
   Hromadka, Theodore V.
   Chang, Howard H.
TI Calibrating the USLE P-factor using program FLUVIAL-12
SO JOURNAL OF SOIL AND WATER CONSERVATION
LA English
DT Editorial Material
ID SOIL LOSS
C1 [Hromadka, Theodore V.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
   [Hromadka, Theodore V.] Calif State Univ Fullerton, Dept Math, Fullerton, CA 92634 USA.
   [Hromadka, Theodore V.] Calif State Univ Fullerton, Dept Geol Sci, Fullerton, CA 92634 USA.
   [Hromadka, Theodore V.] Calif State Univ Fullerton, Dept Environm Studies, Fullerton, CA 92634 USA.
   [Chang, Howard H.] San Diego State Univ, Dept Civil & Environm Engn, San Diego, CA 92182 USA.
   [Chang, Wayne W.; Chang, Howard H.] Chang Consultants, Rancho Santa Fe, CA 92067 USA.
RP Chang, WW (reprint author), Chang Consultants, Rancho Santa Fe, CA 92067 USA.
NR 18
TC 1
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U1 1
U2 5
PU SOIL WATER CONSERVATION SOC
PI ANKENY
PA 945 SW ANKENY RD, ANKENY, IA 50023-9723 USA
SN 0022-4561
J9 J SOIL WATER CONSERV
JI J. Soil Water Conserv.
PD MAR-APR
PY 2011
VL 66
IS 2
BP 40A
EP 44A
DI 10.2489/jswc.66.2.40A
PG 5
WC Ecology; Soil Science; Water Resources
SC Environmental Sciences & Ecology; Agriculture; Water Resources
GA 737SM
UT WOS:000288588500003
ER

PT J
AU Kipshidze, G
   Hosoda, T
   Sarney, WL
   Shterengas, L
   Belenky, G
AF Kipshidze, Gela
   Hosoda, Takashi
   Sarney, Wendy L.
   Shterengas, Leon
   Belenky, Gregory
TI High-Power 2.2-mu m Diode Lasers With Metamorphic Arsenic-Free
   Heterostructures
SO IEEE PHOTONICS TECHNOLOGY LETTERS
LA English
DT Article
DE Diode laser; GaSb; infrared; metamorphic
ID QUANTUM-WELL LASERS; MU-M; TEMPERATURE; LAYERS; PARAMETERS; BUFFER
AB Metamorphic Ga(0.84) In(0.16) Sb virtual substrates with lattice constants 0.9% larger than those of GaSb were developed by solid-source molecular beam epitaxy. The mismatch between the parent GaSb and the virtual substrate was accommodated by a network of misfit dislocations formed in GaInSb buffer layers with linearly graded indium and gallium compositions. Arsenic-free laser heterostructures emitting at 2.2 mu m room temperature were grown on virtual substrates. The antimony was the only group V element used in growth. These novel diode lasers operate at room temperature and generate above 1.4 W of continuous-wave (CW) power.
C1 [Kipshidze, Gela; Hosoda, Takashi; Shterengas, Leon; Belenky, Gregory] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
   [Kipshidze, Gela] Power Photon Corp, Stony Brook, NY 11790 USA.
   [Sarney, Wendy L.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Kipshidze, G (reprint author), SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
EM gela@ece.sunysb.edu; thosoda@ece.sunysb.edu; wendy.l.sarney@us.army.mil;
   leon@ece.sunysb.edu; garik@ece.sunysb.edu
FU U.S. Air Force Office of Scientific Research [FA95500810458]; National
   Science Foundation [DMR0710154]; U.S. Army Research Office
   [W911NF0610399]
FX Manuscript received October 28, 2010; revised December 01, 2010;
   accepted December 18, 2010. Date of publication December 30, 2010; date
   of current version February 24, 2011. This work was supported by the
   U.S. Air Force Office of Scientific Research under contract
   FA95500810458, by the National Science Foundation under Grant
   DMR0710154, and by the U.S. Army Research Office under Contract
   W911NF0610399.
NR 15
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U1 4
U2 14
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1041-1135
J9 IEEE PHOTONIC TECH L
JI IEEE Photonics Technol. Lett.
PD MAR 1
PY 2011
VL 23
IS 5
BP 317
EP 319
DI 10.1109/LPT.2010.2103053
PG 3
WC Engineering, Electrical & Electronic; Optics; Physics, Applied
SC Engineering; Optics; Physics
GA 732CK
UT WOS:000288160600015
ER

PT J
AU West, KE
   Jablonski, MR
   Warfield, B
   Cecil, KS
   James, M
   Ayers, MA
   Maida, J
   Bowen, C
   Sliney, DH
   Rollag, MD
   Hanifin, JP
   Brainard, GC
AF West, Kathleen E.
   Jablonski, Michael R.
   Warfield, Benjamin
   Cecil, Kate S.
   James, Mary
   Ayers, Melissa A.
   Maida, James
   Bowen, Charles
   Sliney, David H.
   Rollag, Mark D.
   Hanifin, John P.
   Brainard, George C.
TI Blue light from light-emitting diodes elicits a dose-dependent
   suppression of melatonin in humans
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE pineal; light-emitting diode
ID SEASONAL AFFECTIVE-DISORDER; SHORT-WAVELENGTH LIGHT; HUMAN CIRCADIAN
   SYSTEM; HIGH-SENSITIVITY; ACTION SPECTRUM; GANGLION-CELLS;
   PHOTORECEPTORS; RHYTHMS; NIGHT; ROD
AB West KE, Jablonski MR, Warfield B, Cecil KS, James M, Ayers MA, Maida J, Bowen C, Sliney DH, Rollag MD, Hanifin JP, Brainard GC. Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans. J Appl Physiol 110: 619-626, 2011. First published December 16, 2010; doi:10.1152/japplphysiol.01413.2009.-Light suppresses melatonin in humans, with the strongest response occurring in the short-wavelength portion of the spectrum between 446 and 477 nm that appears blue. Blue monochromatic light has also been shown to be more effective than longer-wavelength light for enhancing alertness. Disturbed circadian rhythms and sleep loss have been described as risk factors for astronauts and NASA ground control workers, as well as civilians. Such disturbances can result in impaired alertness and diminished performance. Prior to exposing subjects to short-wavelength light from light-emitting diodes (LEDs) (peak lambda = 469 nm; 1/2 peak bandwidth = 26 nm), the ocular safety exposure to the blue LED light was confirmed by an independent hazard analysis using the American Conference of Governmental Industrial Hygienists exposure limits. Subsequently, a fluence-response curve was developed for plasma melatonin suppression in healthy subjects (n = 8; mean age of 23.9 +/- 0.5 years) exposed to a range of irradiances of blue LED light. Subjects with freely reactive pupils were exposed to light between 2: 00 and 3: 30 AM. Blood samples were collected before and after light exposures and quantified for melatonin. The results demonstrate that increasing irradiances of narrowband blue-appearing light can elicit increasing plasma melatonin suppression in healthy subjects (P < 0.0001). The data were fit to a sigmoidal fluence-response curve (R(2) = 0.99; ED(50) = 14.19 mu W/cm(2)). A comparison of mean melatonin suppression with 40 mu W/cm(2) from 4,000 K broadband white fluorescent light, currently used in most general lighting fixtures, suggests that narrow bandwidth blue LED light may be stronger than 4,000 K white fluorescent light for suppressing melatonin.
C1 [West, Kathleen E.; Jablonski, Michael R.; Warfield, Benjamin; Cecil, Kate S.; James, Mary; Ayers, Melissa A.; Rollag, Mark D.; Hanifin, John P.; Brainard, George C.] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA.
   [Maida, James; Bowen, Charles] NASA, Lyndon B Johnson Space Ctr, Habitabil & Human Factors Branch, Houston, TX 77058 USA.
   [Sliney, David H.] USA, Environm Hyg Agcy, Aberdeen Proving Ground, Aberdeen, MD USA.
RP Brainard, GC (reprint author), Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA.
EM george.brainard@jefferson.edu
FU National Space Biomedical Research Institute through NASA [NCC 9-58]
FX This work is supported by the National Space Biomedical Research
   Institute through NASA NCC 9-58.
NR 61
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U1 4
U2 43
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAR
PY 2011
VL 110
IS 3
BP 619
EP 626
DI 10.1152/japplphysiol.01413.2009
PG 8
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 731RN
UT WOS:000288127100008
PM 21164152
ER

PT J
AU Cox, DW
   Ghahramanlou-Holloway, M
   Szeto, EH
   Greene, FN
   Engel, C
   Wynn, GH
   Bradley, J
   Grammer, G
AF Cox, Daniel W.
   Ghahramanlou-Holloway, Marjan
   Szeto, Edwin H.
   Greene, Farrah N.
   Engel, Charles
   Wynn, Gary H.
   Bradley, John
   Grammer, Geoffrey
TI Gender Differences on Documented Trauma Histories Inpatients Admitted to
   a Military Psychiatric Unit for Suicide-related Thoughts or Behaviors
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Suicide; trauma; gender; military; inpatient
ID CHILDHOOD SEXUAL-ABUSE; RISK-FACTORS; PREVALENCE; VETERANS; BEHAVIOR;
   MORTALITY; IDEATION; NEGLECT; SAMPLE; WOMEN
AB Suicide is a leading cause of death among men and women in the United States Military. Using a retrospective chart review design, the current study investigated gender differences on documented traumas for people admitted to a military inpatient psychiatric unit for suicide-related thoughts or behaviors (N = 656). Men more often had no documented lifetime traumas and women more often had 2 or more trauma types. Women had significantly more documented incidences of childhood sexual abuse, adulthood sexual assault, adulthood physical assault, and pregnancy loss. The gender gap in documented trauma types for childhood and adulthood traumas persisted even after adjusting for demographic variables, psychiatric diagnoses, and comorbid trauma types (i.e., trauma types other than the one being used as the dependent variable). Given the observed gender differences in documented traumas, professionals working with military women admitted for suicide-related thoughts or behaviors need to consider trauma in the context of treatment.
C1 [Cox, Daniel W.; Ghahramanlou-Holloway, Marjan; Szeto, Edwin H.; Greene, Farrah N.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Engel, Charles; Bradley, John; Grammer, Geoffrey] Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA.
   [Wynn, Gary H.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA.
RP Ghahramanlou-Holloway, M (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd,B3050, Bethesda, MD 20814 USA.
EM mholloway@usuhs.mil
FU Uniformed Services University of the Health Sciences
FX Funding for this study was provided by the Uniformed Services University
   of the Health Sciences in the form of a new faculty startup package for
   Dr. Marjan Ghahramanlou-Holloway.
NR 42
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U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3018
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD MAR
PY 2011
VL 199
IS 3
BP 183
EP 190
DI 10.1097/NMD.0b013e31820c71c9
PG 8
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 726CG
UT WOS:000287695400008
PM 21346489
ER

PT J
AU Riviere, LA
   Edens, EN
   Adler, AB
   Bliese, PD
   Klocko, RP
   Hoge, CW
AF Riviere, Lyndon A.
   Edens, Edward N.
   Adler, Amy B.
   Bliese, Paul D.
   Klocko, Robert P.
   Hoge, Charles W.
TI Modifying Instructions on the Posttraumatic Stress Disorder Checklist
   for Military Populations Does Not Change Symptom Reporting
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Posttraumatic stress disorder checklist; PTSD prevalence; PTSD symptoms;
   soldiers
ID MENTAL-HEALTH PROBLEMS; IRAQ; PREVALENCE; COMBAT; AFGHANISTAN; PTSD;
   CARE
AB This study investigates whether modifying the instructions of the Posttraumatic Stress Disorder Checklist (PCL) for military survey research changes posttraumatic stress disorder (PTSD) symptom reporting or prevalence. The sample consisted of 1691 soldiers who were randomly assigned to complete 1 of 3 versions of the PCL, which differed only in the wording of the instructions. Group differences in demographic variables, combat exposure, mean PTSD symptoms, and PTSD prevalence estimates were examined. Results showed that there were no statistically significant differences in the outcomes across the PCL versions. The findings indicate that researchers may make modifications to the PCL instructions to meet research needs without affecting PTSD symptom reporting or prevalence estimates.
C1 [Riviere, Lyndon A.; Edens, Edward N.; Bliese, Paul D.; Klocko, Robert P.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
   [Adler, Amy B.] USA, Med Res Unit Europe, Heidelberg, Germany.
RP Riviere, LA (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM lyndon.riviere@amedd.army.mil
FU Military Operational Medicine Research Area Directorate, U.S. Army
   Medical Research and Materiel Command, Fort Detrick, MD
FX Supported by the Military Operational Medicine Research Area
   Directorate, U.S. Army Medical Research and Materiel Command, Fort
   Detrick, MD.
NR 14
TC 12
Z9 12
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-3018
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD MAR
PY 2011
VL 199
IS 3
BP 199
EP 202
DI 10.1097/NMD.0b013e31820caee4
PG 4
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA 726CG
UT WOS:000287695400011
PM 21346492
ER

PT J
AU Gill, NW
   Konitzer, LN
   Hoppes, CW
AF Gill, Norman W.
   Konitzer, Lisa N.
   Hoppes, Carrie W.
TI Lumbar Total Disc Replacement
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Gill, Norman W.; Konitzer, Lisa N.] Army Baylor Univ, San Antonio, TX USA.
   [Gill, Norman W.; Konitzer, Lisa N.] Brooke Army Med Ctr, San Antonio, TX USA.
   [Hoppes, Carrie W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Gill, NW (reprint author), Army Baylor Univ, San Antonio, TX USA.
NR 2
TC 0
Z9 0
U1 0
U2 1
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD MAR
PY 2011
VL 41
IS 3
BP 200
EP 200
DI 10.2519/jospt.2011.0405
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 732LL
UT WOS:000288186500010
PM 21364289
ER

PT J
AU Masini, BD
   Stinner, DJ
   Waterman, SM
   Wenke, JC
AF Masini, Brendan D.
   Stinner, Daniel J.
   Waterman, Scott M.
   Wenke, Joseph C.
TI Bacterial Adherence to Suture Materials
SO JOURNAL OF SURGICAL EDUCATION
LA English
DT Article
DE suture; infection; bacterial adherence; wound complication
ID SURGICAL SUTURES; INFECTION; MODEL
AB BACKGROUND: Wound infections may be problematic for physicians. Whether a practitioner is managing complex penetrating trauma or a skin biopsy, there may be a need for suture closure. Suture material is an operator dependent variable and while little objective data exist to guide the choice of suture, it may play a role in wound infection. This study evaluates bacterial adherence to commonly used suture materials with a bio-luminescent in vitro model.
   METHODS: In all, 11 strands of size 2-0 poliglecaprone suture (Monocryl; Ethicon, Inc, Somerville, New Jersey), polypropylene suture (Prolene; Ethicon, Inc), silk suture (Ethicon, Inc), polyglycolic acid suture (Vicryl; Ethicon, Inc), and antimicrobial polyglycolic acid suture treated with triclosan (VicrylPlus; Ethicon, Inc) were immersed in a broth of Staphylococcus aureus engineered to emit photons. After biofilm formation, the suture strands were irrigated and imaged with a photon-capturing camera system yielding a total photon count that correlates with residual bacteria.
   RESULTS: The Vicryl suture had the highest counts and was statistically significant in bacterial adherence versus all other sutures. No other suture material was significantly different from any other.
   CONCLUSIONS: This study gives data to guide the selection of suture materials. Absorbable braided suture should not be used in closure of contaminated wounds or wounds at risk for developing infection. The antibiotic impregnated absorbable braided suture was similar to the other suture types; however, it is at risk for reverting to the properties of its untreated counterpart over time. The bacterial adherence of suture materials should be taken into account by all practitioners when closing wounds or debriding infected wounds. (J Surg 68: 101-104. (c) 2011 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.)
C1 [Masini, Brendan D.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
   [Waterman, Scott M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Masini, BD (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Brendam.Masini@amedd.army.mil
OI Stinner, Daniel/0000-0002-8981-6262
NR 11
TC 34
Z9 34
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1931-7204
J9 J SURG EDUC
JI J. Surg. Educ.
PD MAR-APR
PY 2011
VL 68
IS 2
BP 101
EP 104
DI 10.1016/j.jsurg.2010.09.015
PG 4
WC Education, Scientific Disciplines; Surgery
SC Education & Educational Research; Surgery
GA 731YG
UT WOS:000288146100004
PM 21338964
ER

PT J
AU Balkin, TJ
   Horrey, WJ
   Graeber, RC
   Czeisler, CA
   Dinges, DF
AF Balkin, Thomas J.
   Horrey, William J.
   Graeber, R. Curtis
   Czeisler, Charles A.
   Dinges, David F.
TI The challenges and opportunities of technological approaches to fatigue
   management
SO ACCIDENT ANALYSIS AND PREVENTION
LA English
DT Article
DE Fatigue management; Technology; Driver/operator monitoring; User
   acceptance; Fitness-for-duty
ID OPTICAL COMPUTER RECOGNITION; DRIVER FATIGUE; ADAPTIVE AUTOMATION;
   SLEEP-APNEA; PERFORMANCE; COUNTERMEASURES; ALERTNESS; AWARENESS;
   WORKLOAD; SYSTEMS
AB There are a number of different strategies to mitigate the effects of fatigue in transportation and other occupational settings. Many are centered on regulatory or organizational approaches, such as work scheduling restriction and employer screening practices. While these generally benefit safety and productivity, there are clearly limitations to these approaches. Technologies that objectively detect or predict operator fatigue may be used to effectively complement or even supplant organizational or regulatory approaches. Over the past decade and a half, there have been considerable advances in relevant technologies, including onboard devices that monitor drivers' state or level of performance as well as devices that predict fatigue in advance of a work cycle or trip. In this paper, we discuss the challenges and opportunities for technological approaches to fatigue management, beginning with a discussion of the "ideal" system, followed by some of the general issues and limitations of current technologies. We also discuss some of the critical and outstanding issues related to the human interaction with these systems, including user acceptance and compliance. Finally, we discuss future directions in next generation technology for fatigue management. (C) 2010 Published by Elsevier Ltd.
C1 [Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA.
   [Horrey, William J.] Liberty Mutual Res Inst Safety, Hopkinton, MA USA.
   [Graeber, R. Curtis] Graeber Grp Ltd, Seattle, WA USA.
   [Czeisler, Charles A.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
   [Dinges, David F.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
RP Balkin, TJ (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave,Room 2A26, Silver Spring, MD 20910 USA.
EM thomas.balkin@us.army.mil
NR 61
TC 33
Z9 33
U1 4
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0001-4575
J9 ACCIDENT ANAL PREV
JI Accid. Anal. Prev.
PD MAR
PY 2011
VL 43
IS 2
SI SI
BP 565
EP 572
DI 10.1016/j.aap.2009.12.006
PG 8
WC Ergonomics; Public, Environmental & Occupational Health; Social
   Sciences, Interdisciplinary; Transportation
SC Engineering; Public, Environmental & Occupational Health; Social
   Sciences - Other Topics; Transportation
GA 725AI
UT WOS:000287617200006
PM 21130217
ER

PT J
AU Friedl, KE
AF Friedl, Karl E.
TI Size matters
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Editorial Material
ID OVERWEIGHT; OBESITY
C1 USA, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Friedl, KE (reprint author), USA, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
EM karl.friedl@us.army.mil
OI Friedl, Karl/0000-0002-3134-8427
NR 8
TC 1
Z9 1
U1 1
U2 3
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
   USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2011
VL 93
IS 3
BP 485
EP 486
DI 10.3945/ajcn.110.011122
PG 2
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 722ZN
UT WOS:000287475000004
PM 21270381
ER

PT J
AU Packnett, ER
   Niebuhr, DW
   Bedno, SA
   Cowan, DN
AF Packnett, Elizabeth R.
   Niebuhr, David W.
   Bedno, Sheryl A.
   Cowan, David N.
TI Body mass index, medical qualification status, and discharge during the
   first year of US Army service
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID RISK-FACTORS; MILITARY PERSONNEL; AIR-FORCE; OBESITY EPIDEMIC;
   PHYSICAL-FITNESS; INJURIES; ASSOCIATION; OVERWEIGHT; ATTRITION; TRENDS
AB Background: The high prevalence of overweight and obesity in military recruits and in the US population as a whole necessitates understanding the health effects of body composition and associated morbidity.
   Objective: In this study, we examined the effect of body mass index (BMI; in kg/m(2)) and medical status on premature discharge from the US Army in a large cohort of first-time-enlisted, active-duty soldiers.
   Design: We determined the odds ratios (ORs) associated with BMI and medical status at enlistment by using a retrospective cohort of first-time, active-duty army recruits.
   Results: ORs for BMI, calculated by using 24-24.9 as a reference, exhibited a U-shaped pattern. Soldiers with a BMI > 34 had the highest ORs for all-cause (OR: 1.47; 95% CI: 1.32, 1.64) and medical (OR: 1.68; 95% CI: 1.46, 1.93) discharges. A BMI < 17 was 1.35 times as likely (95% CI: 1.02, 1.80) to result in an all-cause discharge and 1.45 times as likely (95% CI: 1.01, 2.08) to result in a medical discharge. ORs for soldiers who required a medical reexamination did not vary when all-cause discharge (OR: 1.10; 95% CI: 1.06, 1.14) and medical discharge (OR: 1.10; 95% CI: 1.05, 1.15) were compared. The medical discharge OR for soldiers who required a medical waiver to enter the army (OR: 1.56; 95% CI: 1.48, 1.64) was higher than the OR for all-cause discharge (OR: 1.27; 95% CI: 1.22, 1.32).
   Conclusion: Enlistment BMI and medical qualification status play an important role in early discharge and may provide a valuable tool in the development of fitness, nutrition, and injury-prevention interventions in higher-risk groups. Am J Clin Nutr 2011;93:608-14.
C1 [Packnett, Elizabeth R.; Niebuhr, David W.; Bedno, Sheryl A.; Cowan, David N.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA.
   [Packnett, Elizabeth R.; Cowan, David N.] Allied Technol Grp Inc, Rockville, MD USA.
   [Bedno, Sheryl A.] Dwight D Eisenhower Army Med Ctr, Occupat Hlth Clin, Ft Gordon, GA USA.
RP Packnett, ER (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM elizabeth.packnett1@us.army.mil
FU Department of the Army; US Military Entrance Processing Command; US Army
   Accessions Command
FX Supported by the Department of the Army. The Assessment of Recruit
   Motivation and Strength Study and Program were funded by the US Military
   Entrance Processing Command and the US Army Accessions Command,
   respectively.
NR 44
TC 16
Z9 17
U1 1
U2 5
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
   USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2011
VL 93
IS 3
BP 608
EP 614
DI 10.3945/ajcn.110.007070
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 722ZN
UT WOS:000287475000021
PM 21248187
ER

PT J
AU Felt, SA
   Wasfy, MO
   El-Tras, WF
   Samir, A
   Rahaman, BA
   Boshra, M
   Parker, TM
   Hatem, ME
   El-Bassiouny, AA
   Murray, CK
   Pimentel, G
AF Felt, Stephen A.
   Wasfy, Momtaz O.
   El-Tras, Wael F.
   Samir, Ahmed
   Rahaman, Bassem Abdel
   Boshra, Marie
   Parker, Tina M.
   Hatem, Mahmoud Essam
   El-Bassiouny, Ahmed Ahmed
   Murray, Clinton K.
   Pimentel, Guillermo
TI Cross-Species Surveillance of Leptospira in Domestic and Pen-Domestic
   Animals in Mahalla City, Gharbeya Governorate, Egypt
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID ACUTE FEBRILE ILLNESS; PATHOGENIC LEPTOSPIRES; CANINE LEPTOSPIROSIS;
   INFECTION; SHEEP; EAST; FARM; DOGS; PCR
AB A survey of 179 animals (black rats, dogs, sheep, buffaloes, cattle, donkeys, weasels, and cats) for Leptospira infection was conducted in Mahalla City (Lower Egypt). Blood, urine, and kidney were collected and tested by culture, microscopic agglutination test (MAT), and/or polymerase chain reaction (PCR). Among rats, 26% were positive by PCR, including 7% that were also positive by culture for L. interrogans serovars Grippotyphosa, Pyrogenes, and Icterohaemorrhagiae. L. borpetersenii serovar Polonica was isolated for the first time in Egypt in three rats. MAT titers >= 1:800 were observed in 11% of rats and 12% of dogs. L. interrogans serovar Grippotyphosa was detected in one cat. Sheep and donkeys were negative for leptospirosis by all methods. Buffaloes and cattle were seropositive in 20% and 44% of animals, respectively. Data indicate that several pathogenic serovars are circulating in the animals, which may pose exposure risks and account for high rates of acute febrile illness.
C1 [Wasfy, Momtaz O.; Rahaman, Bassem Abdel; Boshra, Marie; Pimentel, Guillermo] USN, Med Res Unit 3, Lab Unit, Cairo 11517, Egypt.
   [Felt, Stephen A.] Stanford Univ, Dept Comparat Med, Stanford, CA 94305 USA.
   [Parker, Tina M.] NIAID, TB Leprosy & Other Mycobacterial Dis Resp Dis Bra, DMID, NIH,DHHS, Bethesda, MD 20892 USA.
   [El-Tras, Wael F.; El-Bassiouny, Ahmed Ahmed] Kafr El Sheik Univ, Fac Vet Med, Dept Hyg & Prevent Med, Kafr Al Sheikh, Egypt.
   [Samir, Ahmed] Cairo Univ, Fac Vet, Dept Microbiol, Coll Med, Cairo, Egypt.
   [Hatem, Mahmoud Essam] Cairo Univ, Fac Vet Med, Dept Microbiol, Cairo, Egypt.
   [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
RP Wasfy, MO (reprint author), USN, Med Res Unit 3, Lab Unit, 3A Imtidad Ramses St, Cairo 11517, Egypt.
EM felt@stanford.edu; momtaz.wasfy.eg@med.navy.mil; wael_tras@yahoo.com;
   ahmedsamir121@hotmail.com; bassem.abdel-rahman.eg@med.navy.mil;
   marie.boshra@gmail.com; parkerti@niaid.nih.gov; essamhatem@yahoo.com;
   bassiounya@yahoo.com; clinton.murray@us.army.mil
OI El-Tras, Wael/0000-0003-1276-7164; Pimentel,
   Guillermo/0000-0003-2464-1526
FU Global Emerging Infections Surveillance (GEIS); Institutional Animal
   Care and Use Committee of the US Naval Medical Research Unit-3 (NAMU-3);
   Accreditation of the International Association of Assessment of
   Laboratory Animal Care (AAALAC)
FX The opinions and assertions contained herein are the private ones of the
   authors and are not to be construed as official or reflecting the views
   of the US Navy Department or Egypt. Copyright statement: some of the
   authors are employees of the US Government, and this work was prepared
   as part of their official duties. Title 17 U.S.C. 105 provides that
   "copyright protection under this title is not available for any work of
   the United States Government." Title 17 U.S.C. 001 defines a US
   Government work as a work prepared by a military service member or
   employee of the US Government as part of that person's official duties.
   This work was funded by Global Emerging Infections Surveillance (GEIS)
   in compliance with the regulations of the Institutional Animal Care and
   Use Committee of the US Naval Medical Research Unit-3 (NAMU-3) and
   Accreditation of the International Association of Assessment of
   Laboratory Animal Care (AAALAC).
NR 39
TC 16
Z9 16
U1 0
U2 7
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD MAR
PY 2011
VL 84
IS 3
BP 420
EP 425
DI 10.4269/ajtmh.2011.10-0393
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 730AK
UT WOS:000287995600011
PM 21363980
ER

PT J
AU Mansi, IA
AF Mansi, Ishak A.
TI The Effect of Financial Incentives on Hospitals That Serve Poor Patients
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Letter
ID HEART-FAILURE; OUTCOMES
C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Mansi, IA (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
NR 5
TC 0
Z9 0
U1 1
U2 3
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD MAR 1
PY 2011
VL 154
IS 5
BP 370
EP 370
DI 10.7326/0003-4819-154-5-201103010-00013
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 727LA
UT WOS:000287799900010
PM 21357915
ER

PT J
AU McBride, M
   Tran, P
   Letowski, T
   Patrick, R
AF McBride, Maranda
   Tran, Phuong
   Letowski, Tomasz
   Patrick, Rafael
TI The effect of bone conduction microphone locations on speech
   intelligibility and sound quality
SO APPLIED ERGONOMICS
LA English
DT Article
DE Bone conduction microphone; Communication; Speech intelligibility; Sound
   quality
ID PAIRED-COMPARISON JUDGMENTS; ACQUISITION TEST CAT; BACKGROUND-NOISE;
   SENSITIVITY; LISTENERS; HEAD
AB This paper presents the results of three studies of intelligibility and quality of speech recorded through a bone conduction microphone (BCM). All speech signals were captured and recorded using a Temco HG-17 BCM. Twelve locations on or close to the skull were selected for the BCM placement. In the first study, listeners evaluated the intelligibility and quality of the bone conducted speech signals presented through traditional earphones. Listeners in the second study evaluated the intelligibility and quality of signals presented through a loudspeaker. In the third study the signals were reproduced through a bone conduction headset: however, signal evaluation was limited to speech intelligibility only. In all three studies, the Forehead and Temple BCM locations yielded the highest intelligibility and quality rating scores. The Collarbone location produced the least intelligible and lowest quality signals across all tested BCM locations. (C) 2010 Elsevier Ltd and The Ergonomics Society. All rights reserved.
C1 [McBride, Maranda; Patrick, Rafael] Embry Riddle Aeronaut Univ, Dept Human Factors & Syst, Daytona Beach, FL 32114 USA.
   [Tran, Phuong; Letowski, Tomasz] USA, Auditory Res Grp, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP McBride, M (reprint author), N Carolina Agr & Tech State Univ, Dept Management, 1601 E Market St, Greensboro, NC 27411 USA.
EM mcbride@ncat.edu; ptran@arl.army.mil; trl2@arl.army.mil;
   patri39b@erau.edu
FU United States Army Research Laboratory - Human Research and Engineering
   Directorate (Aberdeen, MD); Embry-Riddle Aeronautical University
   (Daytona Beach, FL)
FX This research was funded by the United States Army Research Laboratory -
   Human Research and Engineering Directorate (Aberdeen, MD) and
   Embry-Riddle Aeronautical University (Daytona Beach, FL).
NR 31
TC 8
Z9 8
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0003-6870
J9 APPL ERGON
JI Appl. Ergon.
PD MAR
PY 2011
VL 42
IS 3
BP 495
EP 502
DI 10.1016/j.apergo.2010.09.004
PG 8
WC Engineering, Industrial; Ergonomics; Psychology, Applied
SC Engineering; Psychology
GA 713BL
UT WOS:000286709900012
PM 20934172
ER

PT J
AU Ahantarig, A
   Chauvatcharin, N
   Ruang-areerate, T
   Baimai, V
   Kittayapong, P
AF Ahantarig, Arunee
   Chauvatcharin, Nopmanee
   Ruang-areerate, Toon
   Baimai, Visut
   Kittayapong, Pattamaporn
TI Infection Incidence and Relative Density of the Bacteriophage WO-B in
   Aedes albopictus Mosquitoes from Fields in Thailand
SO CURRENT MICROBIOLOGY
LA English
DT Article
ID CULEX-PIPIENS; WOLBACHIA-PIPIENTIS; VARIABILITY; INCOMPATIBILITY;
   TRANSMISSION; ENDOSYMBIONT; INSECTS
AB We have used real-time quantitative PCR to measure, for the first time, the relative phage WO-B orf7 density and infection incidence in Aedes albopictus mosquitoes from fields in Thailand. Our results showed that the infection incidence of phage WO-B in this mosquito, sampled from geographically different places in Thailand, was 97.9%. Average relative densities of the offspring were different when collected from diverse parts and reared under the same conditions in the laboratory. Our results also revealed that geographical differences within Thailand did not influence the maternal transmission rate of bacteriophage WO-B. In addition, the orf7 loci might not be strictly associated with Wolbachia, because less than 100% of them were maternally inherited. This discovery does not support the hypothesis that bacteriophage WO-B is involved in Aedes albopictus' cytoplasmic incompatibility. Whether this bacteriophage actually is involved in Wolbachia-induced cytoplasmic incompatibility in this mosquito thus needs further investigation, and additional densities of phage WO-B loci should be integrated.
C1 [Ahantarig, Arunee; Chauvatcharin, Nopmanee; Ruang-areerate, Toon; Baimai, Visut; Kittayapong, Pattamaporn] Mahidol Univ Salaya, Fac Sci, Ctr Excellence Vectors & Vector Borne Dis, Nakhon Pathom 73170, Thailand.
   [Ahantarig, Arunee; Baimai, Visut; Kittayapong, Pattamaporn] Mahidol Univ, Fac Sci, Dept Biol, Bangkok 10400, Thailand.
   [Ruang-areerate, Toon] Armed Forces Res Inst Med Sci, Div Res, Epidemiol Sect, Bangkok 10400, Thailand.
RP Kittayapong, P (reprint author), Mahidol Univ Salaya, Fac Sci, Ctr Excellence Vectors & Vector Borne Dis, Phutthamonthon 4 Rd, Nakhon Pathom 73170, Thailand.
EM scaah@mahidol.ac.th; grpkt@mahidol.ac.th
NR 21
TC 3
Z9 3
U1 2
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0343-8651
EI 1432-0991
J9 CURR MICROBIOL
JI Curr. Microbiol.
PD MAR
PY 2011
VL 62
IS 3
BP 816
EP 820
DI 10.1007/s00284-010-9769-0
PG 5
WC Microbiology
SC Microbiology
GA 726VL
UT WOS:000287754500019
PM 20981548
ER

PT J
AU Sherburn, JA
   Horstemeyer, MF
   Bammann, DJ
   Baumgardner, JR
AF Sherburn, J. A.
   Horstemeyer, M. F.
   Bammann, D. J.
   Baumgardner, J. R.
TI Application of the Bammann inelasticity internal state variable
   constitutive model to geological materials
SO GEOPHYSICAL JOURNAL INTERNATIONAL
LA English
DT Article
DE Transient deformation; Plasticity, diffusion, and creep; Creep and
   deformation; Mechanics, theory, and modelling; Rheology: mantle
ID IRREVERSIBLE-PROCESSES; RECIPROCAL RELATIONS; LOAD RELAXATION;
   ALKALI-HALIDES; CREEP; DEFORMATION; FLOW; METALS; THERMODYNAMICS;
   RHEOLOGY
AB P>We describe how the Bammann internal state variable (ISV) constitutive approach, which has proven highly successful in modelling deformation processes in metals, can be applied with great benefit to silicate rocks and other geological materials in modelling their deformation dynamics. In its essence, ISV theory provides a constitutive framework to account for changing history states that arise from inelastic dissipative microstructural evolution of a polycrystalline solid. In this paper, we restrict our attention to a Bammann ISV elastic-viscoplastic model with temperature and strain rate dependence and use isotropic hardening and anisotropic hardening as our two ISVs. We show the Bammann model captures the inelastic behaviour of olivine aggregates (with and without water), lherzolite (with and without water), Carrara marble and rock salt using some experimental data found in the literature. These examples illustrate that when more experimental stress-strain data are gathered on other rock materials, much more realistic numerical simulation of rock behaviour becomes feasible. Though not available in the literature, we outline a set of experiments to obtain unique Bammann ISV model constants.
C1 [Sherburn, J. A.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Horstemeyer, M. F.; Bammann, D. J.] Mississippi State Univ, Ctr Adv Vehicular Syst, Starkville, MS 39759 USA.
   [Horstemeyer, M. F.; Bammann, D. J.] Mississippi State Univ, Mississippi State, MS 39762 USA.
   [Baumgardner, J. R.] Logos Res Associates, Santa Ana, CA 92704 USA.
RP Sherburn, JA (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM jesse.a.sherburn@usace.army.mil
OI Horstemeyer, Mark/0000-0003-4230-0063
NR 48
TC 5
Z9 7
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0956-540X
J9 GEOPHYS J INT
JI Geophys. J. Int.
PD MAR
PY 2011
VL 184
IS 3
BP 1023
EP 1036
DI 10.1111/j.1365-246X.2010.04917.x
PG 14
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 721NV
UT WOS:000287362500004
ER

PT J
AU Iwakami, M
   Reeves, WK
AF Iwakami, Masahiro
   Reeves, Will K.
TI Mosquito and biting fly surveillance on Camp Zama Army Base, Kanagawa
   Prefecture, Japan
SO JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
LA English
DT Article
DE Culicidae; Simulium; Culicoides; Japan; Tabanus
AB Camp Zama, Japan, and the associated military housing and depot storage areas have been occupied by the US military for over 50 years. The military base has experienced less urbanization and development during those 50 years when compared to the surrounding cities of Zama and Sagamihara. We present an annotated comparative checklist of historical records of biting flies (mosquitoes, black flies, biting midges, stable flies, and horse flies) with recent collections. Overall 24 species of biting flies have been reported from Camp Zama, with 17 of these species collected during the last 5 years. Vectors of human and veterinary pathogens were collected including Anopheles sinensis, Aedes albopictus, Culex tritaeniorhynchus, and Simulium bidentatum. (C) Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society, 2010. Published by Elsevier B.V. All rights reserved.
C1 [Reeves, Will K.] USAG J, Unit 45013, APO, AP 96338 USA.
   [Iwakami, Masahiro] USA, Ctr Hlth Promot & Prevent Med Pacific, Unit MCHB AJ TLD 45006, Dept Army, APO, AP 96343 USA.
RP Reeves, WK (reprint author), USAG J, Unit 45013, Box 2582, APO, AP 96338 USA.
EM wkreeves@gmail.com
NR 22
TC 0
Z9 0
U1 1
U2 4
PU KOREAN SOC APPLIED ENTOMOLOGY
PI SUWON
PA NATL INST AGRICULTURAL SCIENCE & TECHNOLOGY, DIVISION ENTOMOLOGY, RDA,
   249 SEODUN-DONG, SUWON, 441-707, SOUTH KOREA
SN 1226-8615
J9 J ASIA-PAC ENTOMOL
JI J. Asia-Pac. Entomol.
PD MAR
PY 2011
VL 14
IS 1
BP 75
EP 77
DI 10.1016/j.aspen.2010.08.003
PG 3
WC Entomology
SC Entomology
GA 727HH
UT WOS:000287788400014
ER

PT J
AU Bubulac, LO
   Benson, JD
   Jacobs, RN
   Stoltz, AJ
   Jaime-Vasquez, M
   Almeida, LA
   Wang, A
   Wang, L
   Hellmer, R
   Golding, T
   Dinan, JH
   Carmody, M
   Wijewarnasuriya, PS
   Lee, MF
   Vilela, MF
   Peterson, J
   Johnson, SM
   Lofgreen, DF
   Rhiger, D
AF Bubulac, L. O.
   Benson, J. D.
   Jacobs, R. N.
   Stoltz, A. J.
   Jaime-Vasquez, M.
   Almeida, L. A.
   Wang, A.
   Wang, L.
   Hellmer, R.
   Golding, T.
   Dinan, J. H.
   Carmody, M.
   Wijewarnasuriya, P. S.
   Lee, M. F.
   Vilela, M. F.
   Peterson, J.
   Johnson, S. M.
   Lofgreen, D. F.
   Rhiger, D.
TI The Distribution Tail of LWIR HgCdTe-on-Si FPAs: a Hypothetical Physical
   Mechanism
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE HgCdTe; discrete species; Si; FPA; dislocation; enhanced diffusion;
   diffusion pipes
ID MOLECULAR-BEAM EPITAXY
AB A model is proposed to explain disparities found in the operability values and histograms for long-wavelength infrared HgCdTe focal-plane arrays fabricated on Si substrates compared with those fabricated on CdZnTe. The starting point for the model is the close agreement between the aerial density of discrete species (particles, contamination spots, crystalline defects on Si surface) in various interfaces in the HgCdTe/CdTe/Si structure and the density of failed pixels in the array. The density of discrete species is acquired by applying a newly developed variation of the secondary-ion mass spectrometry( SIMS) depth-profiling technique to samples that have been deuterated to enhance detection. A mechanism of selective activation of threading dislocations in a HgCdTe layer on Si is proposed to link discrete species with failed detector pixels.
C1 [Bubulac, L. O.; Benson, J. D.; Jacobs, R. N.; Stoltz, A. J.; Jaime-Vasquez, M.; Almeida, L. A.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA.
   [Bubulac, L. O.] RAND Corp, Santa Monica, CA USA.
   [Wang, A.; Wang, L.] Evans Analyt Grp, Sunnyvale, CA USA.
   [Hellmer, R.; Golding, T.; Dinan, J. H.] Amethyst, Ardmore, OK USA.
   [Carmody, M.] EPIR Technol, Chicago, IL USA.
   [Wijewarnasuriya, P. S.] USA, Res Lab, Adelphi, MD USA.
   [Lee, M. F.; Vilela, M. F.; Peterson, J.; Johnson, S. M.; Lofgreen, D. F.; Rhiger, D.] Raytheon Vis Syst, Goleta, CA USA.
RP Bubulac, LO (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA.
EM lucia.bubulac@gmail.com
NR 15
TC 16
Z9 16
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD MAR
PY 2011
VL 40
IS 3
BP 280
EP 288
DI 10.1007/s11664-010-1505-9
PG 9
WC Engineering, Electrical & Electronic; Materials Science,
   Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA 728GS
UT WOS:000287863200006
ER

PT J
AU Mahajan, A
   Alexander, LS
   Seabolt, BS
   Catrambone, DE
   McClung, JP
   Odle, J
   Pfeiler, TW
   Loboa, EG
   Stahl, CH
AF Mahajan, Avanika
   Alexander, Lindsey S.
   Seabolt, Brynn S.
   Catrambone, Daniel E.
   McClung, James P.
   Odle, Jack
   Pfeiler, T. Wayne
   Loboa, Elizabeth G.
   Stahl, Chad H.
TI Dietary Calcium Restriction Affects Mesenchymal Stem Cell Activity and
   Bone Development in Neonatal Pigs
SO JOURNAL OF NUTRITION
LA English
DT Article
ID MARROW STROMAL CELLS; 1,25-DIHYDROXYVITAMIN D-3; ADIPOCYTE
   DIFFERENTIATION; PARATHYROID-HORMONE; GENE-EXPRESSION; DEFICIENT RATS;
   VITAMIN-D; RECEPTOR; RESORPTION; TURNOVER
AB The effects of dietary calcium (Ca) deficiency on skeletal integrity are well characterized in growing and mature mammals; however, less is known about Ca nutrition during the neonatal period. In this study, we examined the effects of neonatal Ca nutrition on bone integrity, endocrine hormones, and mesenchymal stem cell (MSC) activity. Neonatal pigs (24 +/- 6 h of age) received either a Ca-adequate (1.2 g/100 g) or an similar to 40% Ca-deficient diet for 18 d. Ca deficiency reduced (P < 0.05) bone flexural strength and bone mineral density without major differences in plasma indicators of Ca status. There were no meaningful differences in plasma Ca, phosphate (PO(4)), parathyroid hormone, or 1,25-dihydroxycholecalciferol due to Ca nutrition throughout the study. Calcium deficiency also reduced (P < 0.05) the in vivo proliferation of MSC by similar to 50%. In vitro studies utilizing homologous sera demonstrated that MSC activity was affected (P < 0.05) by both the Ca status of the pig and the sera as well as by their interaction. The results indicate that neonatal Ca nutrition is crucial for bone integrity and suggest that early-life Ca restriction may have long-term effects on bone integrity via programming of MSC. J. Nutr. 141: 373-379, 2011.
C1 [Mahajan, Avanika; Alexander, Lindsey S.; Seabolt, Brynn S.; Odle, Jack; Stahl, Chad H.] N Carolina State Univ, Dept Anim Sci, Lab Dev Nutr, Raleigh, NC 27695 USA.
   [Catrambone, Daniel E.; McClung, James P.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
   [Catrambone, Daniel E.; McClung, James P.] USA, Environm Med Res Inst, Div Nutr, Natick, MA 01760 USA.
   [Pfeiler, T. Wayne; Loboa, Elizabeth G.] N Carolina State Univ, Raleigh, NC 27695 USA.
   [Pfeiler, T. Wayne; Loboa, Elizabeth G.] Univ N Carolina Chapel Hill, Joint Dept Biomed Engn, Raleigh, NC 27695 USA.
RP Stahl, CH (reprint author), N Carolina State Univ, Dept Anim Sci, Lab Dev Nutr, Box 7621, Raleigh, NC 27695 USA.
EM chad_stahl@ncsu.edu
RI McClung, James/A-1989-2009; 
OI Odle, Jack/0000-0003-4965-2096
FU North Carolina Agricultural Research Service; NICHD
FX Supported in part by the North Carolina Agricultural Research Service.
   The opinions or assertions contained herein are the private views of the
   authors and are not to be construed as official or as reflecting the
   views of the Army or the Department of Defense. Any citations of
   commercial organizations and trade names in this report do not
   constitute an official Department of the Army endorsement of approval of
   the products or services of these organizations.; The anti-BrdU antibody
   developed by S.J. Kaufmann was obtained from the Developmental Studies
   Hybridoma Bank developed under the auspices of the NICHD and maintained
   by The University of Iowa, Department of Biological Sciences. A.M.,
   J.P.M., and C.H.S. designed research; all authors conducted research;
   A.M. and C.H.S. analyzed data; A.M. and C.H.S. wrote the paper; and
   C.H.S. had primary responsibility for final content. All authors read
   and approved the final manuscript.
NR 46
TC 6
Z9 6
U1 1
U2 5
PU AMER SOC NUTRITIONAL SCIENCE
PI BETHESDA
PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD MAR
PY 2011
VL 141
IS 3
BP 373
EP 379
DI 10.3945/jn.110.131193
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA 726LU
UT WOS:000287724600004
PM 21248192
ER

PT J
AU Pandey, P
   Bodhidatta, L
   Lewis, M
   Murphy, H
   Shlim, DR
   Cave, W
   Rajah, R
   Springer, M
   Batchelor, T
   Sornsakrin, S
   Mason, CJ
AF Pandey, Prativa
   Bodhidatta, Ladaporn
   Lewis, Michael
   Murphy, Holly
   Shlim, David R.
   Cave, William
   Rajah, Ramachandran
   Springer, Martin
   Batchelor, Trish
   Sornsakrin, Siriporn
   Mason, Carl J.
TI Travelers' Diarrhea in Nepal: An Update on the Pathogens and Antibiotic
   Resistance
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
ID ENTEROTOXIGENIC ESCHERICHIA-COLI; UNITED-STATES; DEVELOPING-COUNTRIES;
   FOREIGN RESIDENTS; EPIDEMIOLOGY; THAILAND; IDENTIFICATION; PREVENTION;
   INFECTION; ORGANISM
AB Methods. A total of 381 cases and 176 controls were enrolled between March 2001 and 2003 in a case-control study. Enrollees were over age 18 years from high socioeconomic countries visiting or living in Nepal. Stool samples were assessed by microbiologic, molecular identification, and enzyme immunoassay (EIA) methods, and antimicrobial susceptibility was determined by disk diffusion. Risk factors were assessed by questionnaires.
   Results. At least one enteropathogen was identified in 263 of 381 (69%) cases and 47 of 176 (27%) controls (p < 0.001). Pathogens significantly detected among cases were Campylobacter (17%), enterotoxigenic Escherichia coli (ETEC) (15%), Shigella (13%), and Giardia (11%). Cyclospora was detected only in cases (8%) mainly during monsoon season. Although 71% of Campylobacter isolates were resistant to ciprofloxacin, 80% of bacterial isolates overall were sensitive to either ciprofloxacin or azithromycin while 20% were intermediately sensitive or resistant. No bacterial isolates were resistant to both drugs.
   Conclusions. The most common pathogens causing TD in Nepal were Campylobacter, ETEC, and Shigella. Because resistance to fluoroquinolone or azithromycin was similar, one of these drugs could be used as empiric therapy for TD with the other reserved for treatment failures.
C1 [Pandey, Prativa; Murphy, Holly; Rajah, Ramachandran] Travel Med Ctr, CIWEC Clin, Kathmandu, Nepal.
   [Bodhidatta, Ladaporn; Sornsakrin, Siriporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand.
   [Lewis, Michael] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Shlim, David R.] Jackson Hole Travel & Trop Med, Kelly, WY USA.
   [Cave, William] Fleet St Clin, London, England.
   [Springer, Martin] Beijing United Family Hosp & Clin, Beijing, Peoples R China.
   [Batchelor, Trish] Travel Doctor Clin, Auckland, New Zealand.
RP Pandey, P (reprint author), Travel Med Ctr, CIWEC Clin, POB 12895, Kathmandu, Nepal.
EM pandey@mos.com.np
OI MASON, CARL/0000-0002-3676-2811
FU Global Emerging Infections Surveillance and Response System, a Division
   of the Armed Forces Health Surveillance Center, Washington, DC, USA
FX The study was supported by the Global Emerging Infections Surveillance
   and Response System, a Division of the Armed Forces Health Surveillance
   Center, Washington, DC, USA. The authors wish to thank Ms Somporn
   Krasaesub for her statistical consultation; Ms Pavinee Srisawatampai for
   her assistance on manuscript preparation; the staff of the CIWEC clinic
   in Kathmandu, Nepal, for their support on enrollment and specimen
   processing; and the staff of the Department of Enteric Diseases, AFRIMS,
   Bangkok, Thailand, for their support on logistic, administration, and
   all laboratory assays.
NR 35
TC 14
Z9 14
U1 0
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1195-1982
J9 J TRAVEL MED
JI J. Travel Med.
PD MAR-APR
PY 2011
VL 18
IS 2
BP 102
EP 108
DI 10.1111/j.1708-8305.2010.00475.x
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA 729CO
UT WOS:000287925900006
PM 21366793
ER

PT J
AU Mascari, TM
   Clark, J
   Gordon, S
   Mitchell, MA
   Rowton, ED
   Stout, R
   Foil, LD
AF Mascari, T. M.
   Clark, J.
   Gordon, S.
   Mitchell, M. A.
   Rowton, E. D.
   Stout, R.
   Foil, L. D.
TI Oral treatment of rodents with insecticides for control of sand flies
   (Diptera: Psychodidae) and the fluorescent tracer technique (FTT) as a
   tool to evaluate potential sand fly control methods
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Feed-through; systemic insecticide; sand fly; Phlebotomus papatasi;
   control
ID PHLEBOTOMUS-PAPATASI DIPTERA; FEED-THROUGH INSECTICIDE; LABORATORY
   EVALUATION; GROWTH-REGULATORS; IVERMECTIN; NOVALURON; MOSQUITOS;
   SANDFLIES; TOXICITY
AB In laboratory studies, insecticides (diflubenzuron, novaluron, methoprene and, pyriproxyfen) that have been incorporated into rodent diets were effective as feed-throughs against sand fly larvae. Novaluron also was effective against sand fly larvae at low concentrations and under simulated field conditions. Ivermectin has been shown to be effective as a systemic insecticide, killing 100% of blood-feeding sand flies for up to seven d after rodents were treated. The fluorescent tracer technique (FTT) is the use of certain fluorescent dyes (rhodamine B or uranine O) as feed-through transtadial biomarkers for phlebotomine sand flies, systemic biomarkers for blood-feeding sand flies, and permanent markers for nectar-feeding sand flies. The results of these laboratory studies provide proof of concept for the FTT and indicate that the FTT could be used to delineate specific foci with rodent/sand fly associations that would be susceptible to control by using feed-through or systemic insecticides, or foci where insecticide-treated sugar baits could be used against sand flies.
C1 [Mascari, T. M.; Foil, L. D.] Louisiana State Univ, Dept Entomol, AgCtr, Baton Rouge, LA 70803 USA.
   [Clark, J.; Gordon, S.] USA, Med Res Unit Kenya, Dpo, AE USA.
   [Mitchell, M. A.] Univ Illinois, Dept Vet Clin Med, Urbana, IL 61801 USA.
   [Rowton, E. D.] Walter Reed Army Inst Res, Silver Spring, MD USA.
   [Stout, R.] Louisiana State Univ, Dept Lab Anim Med, Baton Rouge, LA 70803 USA.
RP Mascari, TM (reprint author), Louisiana State Univ, Dept Entomol, AgCtr, Baton Rouge, LA 70803 USA.
RI Gordon, Scott/B-8875-2011; Rowton, Edgar/A-4474-2012; Rowton,
   Edgar/A-1975-2011
OI Rowton, Edgar/0000-0002-1979-1485
NR 28
TC 6
Z9 6
U1 1
U2 7
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD MAR
PY 2011
VL 36
SU 1
SI SI
BP S132
EP S137
DI 10.1111/j.1948-7134.2011.00122.x
PG 6
WC Entomology
SC Entomology
GA 729CZ
UT WOS:000287927300017
PM 21366765
ER

PT J
AU Wasserberg, G
   Poche, R
   Miller, D
   Chenault, M
   Zollner, G
   Rowton, ED
AF Wasserberg, Gideon
   Poche, Richard
   Miller, David
   Chenault, Michelle
   Zollner, Gabriela
   Rowton, Edgar D.
TI Imidacloprid as a potential agent for the systemic control of sand flies
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Systemic control; sand fly larva control; imidacloprid; sand rat;
   feed-through
ID CALIFORNIA GROUND-SQUIRRELS; FEED-THROUGH INSECTICIDE; IMPREGNATED DOG
   COLLARS; CUTANEOUS LEISHMANIASIS; PHLEBOTOMINE SANDFLIES; LABORATORY
   EVALUATION; CANINE LEISHMANIASIS; PSYCHODIDAE; DIPTERA; CERATOPHYLLIDAE
AB Our goal was to study the effectiveness of the insecticide imidacloprid as a systemic control agent. First, to evaluate the blood-feeding effect, we fed adult female Phlebotomus papatasi with imidacloprid-treated rabbit blood and monitored blood-feeding success and survival. Second, to evaluate the feed-through effectiveness of this insecticide, we fed laboratory rats and sand rats with insecticide-treated food and evaluated the survival of sand fly larvae feeding on rodents' feces. In the blood-feeding experiment, 89.8% mortality was observed with the higher dose (5 mg/ml) and 81.3% with the lower dose (1 mg/ml). In the larvicide experiments, both sand fly species demonstrated a typical dose-response curve with the strongest lethal effect for the 250 ppm samples. Lutzomyia longipalpis larvae, however, were less sensitive. In all experiments, 1st instar larvae were more sensitive than the older stages. First instar P. papatasi larvae feeding on sand rat feces passed the larvicidal threshold of 90% mortality at doses higher than 50 ppm. In comparison, in older stages 90% mortality was obtained with a dose of only 250 ppm. Overall, results support the feasibility of imidacloprid as a systemic control agent that takes advantage of the tight ecological association between the reservoir host and the sand fly vector.
C1 [Wasserberg, Gideon; Zollner, Gabriela; Rowton, Edgar D.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
   [Poche, Richard; Miller, David] Genesis Labs, Wellington, CO 80549 USA.
   [Chenault, Michelle] US FDA, Silver Spring, MD 20993 USA.
RP Wasserberg, G (reprint author), Univ N Carolina, Dept Biol, Greensboro, NC 27402 USA.
RI Rowton, Edgar/A-1975-2011
OI Rowton, Edgar/0000-0002-1979-1485
FU U.S. Department of Defense through Armed Forces Pest Management Board
FX This research was funded by a grant from the U.S. Department of Defense,
   Deployed War Fighter Protection Program, through the Armed Forces Pest
   Management Board. Studies were conducted while G. Wasserberg held a
   National Research Council (NRC) Research Associateship at the Walter
   Reed Army Institute of Research. The opinions or assertions contained
   herein are the private views of the author, and are not to be construed
   as official, or as reflecting true views of the Department of the Army
   or the Department of Defense. Research was conducted in compliance with
   the Animal Welfare Act and other federal statutes and regulations
   relating to animals and experiments involving animals and adheres to
   principles stated in the Guide for the Care and Use of Laboratory
   Animals, MRC Publication, 1996 edition.
NR 37
TC 5
Z9 5
U1 0
U2 7
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD MAR
PY 2011
VL 36
SU 1
SI SI
BP S148
EP S156
DI 10.1111/j.1948-7134.2011.00125.x
PG 9
WC Entomology
SC Entomology
GA 729CZ
UT WOS:000287927300020
PM 21366768
ER

PT J
AU Zollner, G
   Orshan, L
AF Zollner, Gabriela
   Orshan, Laor
TI Evaluation of a metofluthrin fan vaporizer device against phlebotomine
   sand flies (Diptera: Psychodidae) in a cutaneous leishmaniasis focus in
   the Judean Desert, Israel
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Sand fly; Phlebotomus; spatial repellent; fan vaporizer; metofluthrin
ID IMPREGNATED PLASTIC STRIPS; HYRAXES PROCAVIA-CAPENSIS; SPATIAL
   REPELLENCY; FIELD-EVALUATION; AEDES-AEGYPTI; PAPER STRIP; MOSQUITOS;
   ANOPHELES; INDONESIA; TROPICA
AB The OFF! Clip-On fan vaporizer device releasing metofluthrin was evaluated against phletobomine sand flies in the Judean Desert, Israel, in October, 2009. A total of 76,400 sand flies was collected, with male flies representing 98.3% Phlebotomus sergenti and 1.7% P. papatasi. Females comprised 43.0% of the total catch and included 6.7% blood-fed females. Similar proportions of flies were collected in both suction and sticky traps. In trials with unbaited suction traps, similar numbers of sand flies were collected in traps with a metofluthrin device, blank device, or no device (i.e., suction only). In suction traps baited with CO(2), higher numbers of P. sergenti males and blood-fed females were collected in traps with a blank device compared to traps with a metofluthrin device. In sticky traps baited with CO(2), there were no significant differences between catches in traps with a metofluthrin device, blank device, or no device. The results suggest metofluthrin from the device is not repellent against sand flies in a field environment despite showing insecticidal activity against flies collected in suction traps.
C1 [Zollner, Gabriela] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA.
   [Orshan, Laor] Minist Hlth, Entomol Lab, Jerusalem, Israel.
RP Zollner, G (reprint author), Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA.
FU U.S. Army Medical Research and Material Command (USAMRMC) [U30015-08-WR]
FX We thank Prof. Avi Israeli, Director General, Israel Ministry of Health
   (MOH), for his continuous support and encouragement. We also thank Liora
   Studenski in the Laboratory of Entomology, Israel MOH, for assisting
   with sand fly identification and laboratory work. We gratefully
   acknowledge the cooperation of the residents of Kfar Adummim. The study
   was funded by the U.S. Army Medical Research and Material Command
   (USAMRMC) Military Infectious Disease Research Program (MIDRP
   #U30015-08-WR). The opinions and assertions contained herein are those
   of the authors and are not to be construed as official or reflecting the
   views of the Department of the Army or the Department of Defense.
NR 26
TC 2
Z9 2
U1 1
U2 4
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD MAR
PY 2011
VL 36
SU 1
SI SI
BP S157
EP S165
DI 10.1111/j.1948-7134.2011.00126.x
PG 9
WC Entomology
SC Entomology
GA 729CZ
UT WOS:000287927300021
PM 21366769
ER

PT J
AU Sano, T
   Randow, CL
AF Sano, Tomoko
   Randow, Charles L.
TI The Effect of Twins on the Mechanical Behavior of Boron Carbide
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
   MATERIALS SCIENCE
LA English
DT Article; Proceedings Paper
CT Symposium on Cost Affordable Titanium III held at the 2010 TMS Annual
   Meeting
CY FEB 14-18, 2010
CL Seattle, WA
SP Minerals, Met & Mat Soc
ID CERAMICS; ARMOR
AB The microstructure and mechanical properties of boron carbide (B4C) samples processed by slip casting were compared with those processed by the conventional hot-pressing technique. Although the quasi-static and dynamic mechanical experiments showed comparable results between the slip-cast and hot-pressed B4C, scanning electron microscopy and electron backscattered diffraction of the B4C samples revealed significant differences in the microstructure. A notable difference was the and consisted of 35 pct of the boundary population in the slip-cast B4C but only 1 pct of the boundary population in the hot-pressed B4C. It was hypothesized that the presence of twins will cause a different failure mechanism. The effect of the twins on the stress state was examined by finite-element simulations and will also be discussed.
C1 [Sano, Tomoko; Randow, Charles L.] USA, Weap & Mat Res Directorate, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sano, T (reprint author), USA, Weap & Mat Res Directorate, Mat & Mfg Sci Div, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM tomoko.sano@us.army.mil
NR 11
TC 9
Z9 9
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD MAR
PY 2011
VL 42A
IS 3
BP 570
EP 574
DI 10.1007/s11661-010-0548-0
PG 5
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
   Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 714UO
UT WOS:000286834700007
ER

PT J
AU Flanner, MG
   Shell, KM
   Barlage, M
   Perovich, DK
   Tschudi, MA
AF Flanner, M. G.
   Shell, K. M.
   Barlage, M.
   Perovich, D. K.
   Tschudi, M. A.
TI Radiative forcing and albedo feedback from the Northern Hemisphere
   cryosphere between 1979 and 2008
SO NATURE GEOSCIENCE
LA English
DT Article
ID ARCTIC SEA-ICE; CLIMATE FEEDBACKS; SURFACE; VARIABILITY; SATELLITE;
   MODELS; COVER; CLOUD
AB The extent of snow cover(1) and sea ice(2) in the Northern Hemisphere has declined since 1979, coincident with hemispheric warming and indicative of a positive feedback of surface reflectivity on climate. This albedo feedback of snow on land has been quantified from observations at seasonal timescales(3-6), and century-scale feedback has been assessed using climate models(7-10). However, the total impact of the cryosphere on radiative forcing and albedo feedback has yet to be determined from measurements. Here we assess the influence of the Northern Hemisphere cryosphere on Earth's radiation budget at the top of the atmosphere-termed cryosphere radiative forcing-by synthesizing a variety of remote sensing and field measurements. We estimate mean Northern Hemisphere forcing at -4.6 to -2.2 W m(-2), with a peak in May of -9.0 +/- 2.7 W m(-2). We find that cyrospheric cooling declined by 0.45 W m(-2) from 1979 to 2008, with nearly equal contributions from changes in land snow cover and sea ice. On the basis of these observations, we conclude that the albedo feedback from the Northern Hemisphere cryosphere falls between 0.3 and 1 : 1 W m(-2) K-1, substantially larger than comparable estimates obtained from 18 climate models.
C1 [Flanner, M. G.] Univ Michigan, Dept Atmospher Ocean & Space Sci, Ann Arbor, MI 48109 USA.
   [Shell, K. M.] Oregon State Univ, Coll Ocean & Atmospher Sci, Corvallis, OR 97331 USA.
   [Barlage, M.] Natl Ctr Atmospher Res, Boulder, CO 80307 USA.
   [Perovich, D. K.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA.
   [Tschudi, M. A.] Univ Colorado, Colorado Ctr Astrodynam Res, Boulder, CO 80309 USA.
RP Flanner, MG (reprint author), Univ Michigan, Dept Atmospher Ocean & Space Sci, Ann Arbor, MI 48109 USA.
EM flanner@umich.edu
RI Shell, Karen/C-5161-2009; Flanner, Mark/C-6139-2011
OI Shell, Karen/0000-0002-9059-6842; Flanner, Mark/0000-0003-4012-174X
FU NSF [ATM-0852775, ATM-0904092]
FX We thank C. Fowler and J. Maslanik for providing multi-year sea-ice
   data, T. Estilow and M. J. Brodzik for providing snow and sea-ice data
   and advice, and S. Warren for reviewing the manuscript. MODIS data are
   distributed by the Land Processes Distributed Active Archive Center,
   located at the US Geological Survey Earth Resources Observation and
   Science Center (lpdaac.usgs.gov). The ISCCP D2 data were obtained from
   the International Satellite Cloud Climatology Project web site
   (http://isccp.giss.nasa.gov) maintained by the ISCCP research group at
   NASA Goddard Institute for Space Studies. We acknowledge the modelling
   groups, the Program for Climate Model Diagnosis and Intercomparison and
   the WCRP's Working Group on Coupled Modelling for their roles in making
   available the WCRP CMIP3 multi-model data set. Research was supported by
   NSF ATM-0852775 (M.G.F.) and ATM-0904092 (K.M.S.).
NR 32
TC 99
Z9 102
U1 7
U2 86
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1752-0894
EI 1752-0908
J9 NAT GEOSCI
JI Nat. Geosci.
PD MAR
PY 2011
VL 4
IS 3
BP 151
EP 155
DI 10.1038/NGEO1062
PG 5
WC Geosciences, Multidisciplinary
SC Geology
GA 727LU
UT WOS:000287802300012
ER

PT J
AU Folio, LR
   Fischer, TV
   Shogan, PJ
   Frew, MI
   Kang, PS
   Bunger, R
   Provenzale, JM
AF Folio, Les R.
   Fischer, Tatjana V.
   Shogan, Paul J.
   Frew, Michael I.
   Kang, Pil S.
   Bunger, Rolf
   Provenzale, James M.
TI CT-based Ballistic Wound Path Identification and Trajectory Analysis in
   Anatomic Ballistic Phantoms
SO RADIOLOGY
LA English
DT Article
ID BULLET
AB Purpose: To evaluate the accuracy of computed tomography (CT)-based ballistic wound path identification in phantoms by determining the agreement between actual shooting angles and both trajectory angles measured with a picture archiving and communication system (PACS) angle tool and angles calculated from x, y, z coordinates of the entrance and exit points.
   Materials and Methods: In this institutional review board-approved model study, two simulated legs were shot by a trained marksman from 50 yards at six clinometer-measured angles with a 0.30-06 rifle and then scanned at multidetector CT. Radiologists measured the wound path angles on paracoronal reformations by using a PACS angle tool. Observers determined the Cartesian coordinates of the entrance and exit points of the wound paths on axial CT images by using detailed instructions. Angles were calculated from these coordinates by using a computer arctangent function. Agreement between the angles was evaluated with Bland-Altman plots. Means, ranges, and standard deviations of the angles also were determined.
   Results: Radiologists identified all six wound paths on the CT images. The PACS tool-based measured and coordinate-based calculated angles were within 5 degrees of the shooting angles. Results indicated that in larger study populations, one can be 91% confident that future coordinate-based angle calculations will differ from the actual shooting angle by no more than 5 degrees and 95% confident that PACS tool-based angle measurements will differ from the actual shooting angles by no more than 4.5 degrees. One can be 95% confident that future coordinate-based angle calculations will differ from PACS angle measurements by no more than 4.02 degrees.
   Conclusion: Study results demonstrated the feasibility of consistent wound path identification and the accuracy of trajectory angle determination in models with use of multidetector CT.
C1 [Folio, Les R.] Uniformed Serv Univ Hlth Sci, Dept Radiol, Bethesda, MD 20814 USA.
   [Bunger, Rolf] Uniformed Serv Univ Hlth Sci, Dept Anat, Bethesda, MD 20814 USA.
   [Bunger, Rolf] Uniformed Serv Univ Hlth Sci, Dept Physiol, Bethesda, MD 20814 USA.
   [Bunger, Rolf] Uniformed Serv Univ Hlth Sci, Dept Genet, Bethesda, MD 20814 USA.
   [Fischer, Tatjana V.] Tech Univ Munich, Dept Clin Radiol, Munich, Germany.
   [Shogan, Paul J.; Frew, Michael I.; Kang, Pil S.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA.
   [Provenzale, James M.] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA.
RP Folio, LR (reprint author), Uniformed Serv Univ Hlth Sci, Dept Radiol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM les.folio@nih.gov
NR 12
TC 11
Z9 11
U1 0
U2 1
PU RADIOLOGICAL SOC NORTH AMERICA
PI OAK BROOK
PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA
SN 0033-8419
J9 RADIOLOGY
JI Radiology
PD MAR
PY 2011
VL 258
IS 3
BP 923
EP 929
DI 10.1148/radiol.10100534
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 724JX
UT WOS:000287573100029
PM 21224425
ER

PT J
AU Casper, AF
   Dixon, B
   Earls, J
   Gore, JA
AF Casper, A. F.
   Dixon, B.
   Earls, J.
   Gore, J. A.
TI LINKING A SPATIALLY EXPLICIT WATERSHED MODEL (SWAT) WITH AN IN-STREAM
   FISH HABITAT MODEL (PHABSIM): A CASE STUDY OF SETTING MINIMUM FLOWS AND
   LEVELS IN A LOW GRADIENT, SUB-TROPICAL RIVER
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE spatially explicit watershed modelling; hydraulic fish habitat; resource
   management
ID SENSITIVITY; MANAGEMENT; RESOLUTION; RESOURCES; TOOL; GIS
AB As changes in landuse and the demand for water accelerate, regulators and resource managers are increasingly asked to evaluate water allocation against the need for protection of in-stream habitat. In the United States, only a small number of river basins have the long-term hydrograph data needed to make these assessments. This paper presents an example of how to bridge the conceptual and physical divide between GIS-based watershed modelling of basin-discharge and in-stream hydraulic habitat models. Specifically, we used a Soil and Water Assessment Tool (SWAT) model for the Hillsborough River to produce data for use in a Physical HABitat SIMulation (PHABSIM) model of the same river. This coupling of models allowed us to develop long-term discharge data in ungauged river systems based on watershed characteristics and precipitation records. However this approach is not without important limitations. Results confirm that accuracy of the SWAT-predicted hydrograph declines significantly when either the DEM resolution becomes too coarse or if DEM data are resampled to a coarser or finer resolution. This is due to both changes in the size and shape of the river basin with the varying DEMs and subsequent shifts in the proportions of land use, soils and elevation. Results show the use of 30 m DEMs produced hydrographic patterns amenable for using in-stream habitat protocols like PHABSIM model, especially where little or no hydrographic and land use information exists. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Casper, A. F.] US Army Corps Engn, Engn Res & Dev Ctr, Environm Lab, Aquat Ecol & Invas Species Branch, Vicksburg, MS 39180 USA.
   [Dixon, B.; Earls, J.] Univ S Florida, Geospatial Analyt Lab, Environm Sci Policy & Geog Program, St Petersburg, FL 33701 USA.
   [Gore, J. A.] Univ Tampa, Dept Biol, Tampa, FL 33606 USA.
   [Gore, J. A.] Univ Tampa, Coll Nat & Hlth Sci, Tampa, FL 33606 USA.
RP Casper, AF (reprint author), US Army Corps Engn, Engn Res & Dev Ctr, Environm Lab, Aquat Ecol & Invas Species Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM andrew.f.casper@usace.asrmy.mil
FU USEPA-Office of Research and Development; University of South Florida
   St. Petersburg's Center for Science and Policy in the Coastal
   Environment; Southwest Water Management District
FX This work was funded through combined support from a grant from the
   USEPA-Office of Research and Development and the University of South
   Florida St. Petersburg's Center for Science and Policy in the Coastal
   Environment to Barnali Dixon and James Gore and a Southwest Water
   Management District contract to James Gore.
NR 35
TC 4
Z9 4
U1 3
U2 28
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1535-1459
J9 RIVER RES APPL
JI River Res. Appl.
PD MAR
PY 2011
VL 27
IS 3
BP 269
EP 282
DI 10.1002/rra.1355
PG 14
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA 731AN
UT WOS:000288078800001
ER

PT J
AU Knox, JB
   Dai, JM
   Orchowski, JR
AF Knox, Jeffrey B.
   Dai, Joseph M., III
   Orchowski, Joseph R.
TI Superior segment facet joint violation and cortical violation after
   minimally invasive pedicle screw placement
SO SPINE JOURNAL
LA English
DT Article
DE Minimally invasive; Lumbar spine; Cortical violation; Pedicle screw
ID LUMBAR INTERBODY FUSION; TRANSPEDICULAR INSTRUMENTATION; FIXATION; SPINE
AB BACKGROUND CONTEXT: Minimally invasive approaches to the lumbar spine allow for pedicle screw placement through a muscle-splitting paraspinal approach. These techniques are highly dependent on fluoroscopy and do not allow for direct visualization of anatomic landmarks. The effect of this on the accuracy of pedicle screw placement is not well described. The purpose of this study was to evaluate the rate of violation of the superior segment facet joint and rates of cortical violation after minimally invasive pedicle screw placement.
   PURPOSE: To evaluate the rate of cortical violation and involvement of the superior segment facet after minimally invasive pedicle screw placement.
   STUDY DESIGN/SETTING: Retrospective chart review.
   PATIENT SAMPLE: Patients who underwent minimally invasive pedicle screw placement by a single surgeon between January 2004 and July 2009.
   OUTCOME MEASURES: Violation of the superior segment facet joint or cortical violation identified on computed tomography (CT).
   METHODS: This study consisted of a consecutive series of adult patients undergoing minimally invasive pedicle screw placement by a single surgeon for degenerative lumbar spinal conditions. Routine postoperative CT was obtained and evaluated for involvement of the superior segment facet joint and for cortical violation.
   RESULTS: Sixty-one consecutive patients (282 pedicle screws) met the study criteria and were included in the study, including 42 single-level fusions and 19 two-level fusions. Seven cortical breaches were identified for a rate of 2.48%. Seven patients had involvement of the superior-level facet for an incidence of 11.48%. One patient required revision for a malpositioned pedicle screw.
   CONCLUSIONS: This study revealed a low rate of superior segment facet violation and cortical violation after minimally invasive pedicle screw placement. This rate of superior-level facet involvement is significantly lower than previously reported after open procedures. The rate of cortical violation is similar to previous reports in the literature with a low revision rate. Published by Elsevier Inc.
C1 [Knox, Jeffrey B.; Dai, Joseph M., III; Orchowski, Joseph R.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI USA.
RP Knox, JB (reprint author), Tripler Army Med Ctr, Orthopaed Surg Serv, 1 Jarrett White Rd, Honolulu, HI USA.
EM Jeffrey.bruce.knox@us.army.mil
NR 20
TC 11
Z9 13
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
J9 SPINE J
JI Spine Journal
PD MAR
PY 2011
VL 11
IS 3
BP 213
EP 217
DI 10.1016/j.spinee.2011.01.024
PG 5
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 730DP
UT WOS:000288013200011
PM 21377603
ER

PT J
AU Helgeson, MD
   Lehman, RA
   Sasso, RC
   Dmitriev, AE
   Mack, AW
   Riew, D
AF Helgeson, Melvin D.
   Lehman, Ronald A., Jr.
   Sasso, Rick C.
   Dmitriev, Anton E.
   Mack, Andrew W.
   Riew, Daniel
TI Biomechanical analysis of occipitocervical stability afforded by three
   fixation techniques
SO SPINE JOURNAL
LA English
DT Article
DE Occipitocervical; Occipital condyle; Keel plate; Instrumentation;
   Biomechanics
ID INSTRUMENTATION
AB BACKGROUND CONTEXT: Occipital condyle screws appear to be a novel technique that demands biomechanical consideration. It has the potential to achieve fixation anterior to the axis of rotation while offering a point of fixation in line with the C1/C2 screws.
   PURPOSE: To compare the segmental stability and range of motion (ROM) of standard occipitocervical (OC) screw/rod and plate constructs versus a new technique that incorporates occipital condyle fixation.
   STUDY DESIGN: Human cadaveric biomechanical analysis.
   METHODS: After intact analysis, 10 fresh-frozen human cadaveric OC spine specimens were instrumented bilaterally with C1 lateral mass screws and C2 pedicle screws. Additional occipital instrumentation was tested in random order under the following conditions: standard occipitocervical plate/rod system (Vertex Max; Medtronic, Inc., Minneapolis, MN, USA); occipital condyle screws alone; and occipital condyle screws with the addition of an eyelet screw placed into the occiput bilaterally. After nondestructive ROM testing, specimens were evaluated under computed tomography (CT) and underwent destructive forward flexion failure comparing Group 1 to Group 3.
   RESULTS: There was no significant difference in OC (Occiput-C1) axial rotation and flexion/extension ROM between the standard occipitocervical plate/rod system (Group 1) and the occipital condyle screws with one eyelet screw bilaterally (Group 3). Furthermore, the occipital condyle screws alone (Group 2) did allow significantly more flexion/extension compared with Group 1. Interestingly, the two groups with occipital condyle screws (Groups 2 and 3) had significantly less lateral bending compared with Group 1. During CT analysis, the mean occipital condyle width was 10.8 mm (range, 9.1-12.7 mm), and the mean condylar length was 24.3 mm (range, 20.2-28.5). On destructive testing, there was no significant difference in forward flexion failure between Groups 1 and 3.
   CONCLUSIONS: With instrumentation across the mobile OC junction, our results indicate that similar stability can be achieved with occipital condyle screws/eyelet screws compared with the standard occipitocervical plate/rod system. Published by Elsevier Inc.
C1 [Helgeson, Melvin D.; Mack, Andrew W.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA.
   [Lehman, Ronald A., Jr.; Dmitriev, Anton E.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Spine Res Lab, Washington, DC 20307 USA.
   [Sasso, Rick C.] Indiana Univ Sch Med, Dept Orthopaed Surg, Indiana Spine Grp, Indianapolis, IN 46201 USA.
   [Riew, Daniel] Washington Univ, Sch Med, Dept Orthopaed Surg, Cerv Spine Serv, St Louis, MO 63110 USA.
RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 1528 Blue Meadow Rd, Potomac, MD 20854 USA.
EM armyspine@yahoo.com
FU SpinemedicaMedtronic
FX AED (other relationships, Medtronic); RCS (royalties, Medtronic; stock
   ownership, including options and warrants, Biomet; research support:
   staff/materials, Medtronic, Stryker, Cerapedics, Smith and Nephew); KDR
   (royalties, Biomet, Osprey, Medtronic; stock ownership, including
   options and warrants, Osprey, Expanding Orthopedics, Spineology, Spine
   Medica, Spinal Kinetics, Nexgen Spine, Amedica, Vertiflex, Benvenue,
   Paradigm Spine, PSD; consulting, Spine Medica; speaking/teaching
   arrangements, Medtronic; board of directors, Korean Association of
   Spinal Surgeons, Cervical Spine Research Society; scientific advisory
   board, Spine Medica; grants, SpinemedicaMedtronic; other relationships,
   Medtronic).
NR 7
TC 8
Z9 11
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
J9 SPINE J
JI Spine Journal
PD MAR
PY 2011
VL 11
IS 3
BP 245
EP 250
DI 10.1016/j.spinee.2011.01.021
PG 6
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA 730DP
UT WOS:000288013200016
PM 21377608
ER

PT J
AU Sagripanti, JL
   Lytle, CD
AF Sagripanti, Jose-Luis
   Lytle, C. David
TI Sensitivity to ultraviolet radiation of Lassa, vaccinia, and Ebola
   viruses dried on surfaces
SO ARCHIVES OF VIROLOGY
LA English
DT Article
DE Ebola; Lassa; Vaccinia; Smallpox; Biodefense; UVC radiation;
   Environmental inactivation; Microbial fate; Viral persistence
ID HOST-CELL REACTIVATION; MAMMALIAN-CELLS; INACTIVATION; IRRADIATION;
   SURVIVAL; SMALLPOX; FEVER
AB Germicidal UV (also known as UVC) provides a means to decontaminate infected environments as well as a measure of viral sensitivity to sunlight. The present study determined UVC inactivation slopes (and derived D-37 values) of viruses dried onto nonporous (glass) surfaces. The data obtained indicate that the UV resistance of Lassa virus is higher than that of Ebola virus. The UV sensitivity of vaccinia virus (a surrogate for variola virus) appeared intermediate between that of the two virulent viruses studied. In addition, the three viruses dried on surfaces showed a relatively small but significant population of virions (from 3 to 10 % of virus in the inoculum) that appeared substantially more protected by their environment from the effect of UV than the majority of virions tested. The findings reported in this study should assist in estimating the threat posed by the persistence of virus in environments contaminated during epidemics or after an accidental or intentional release.
C1 [Sagripanti, Jose-Luis; Lytle, C. David] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD USA.
RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD USA.
EM joseluis.sagripanti@us.army.mil
FU Research and Technology Directorate, Edgewood Chemical Biological
   Center, Research Development and Engineering Command, US Army
FX This work was supported by the In-House Laboratory Independent Research
   (ILIR) funds from the Research and Technology Directorate, Edgewood
   Chemical Biological Center, Research Development and Engineering
   Command, US Army. The valuable assistance with Ebola and Lassa viruses
   provided under U. S. Federal contract by Dr. Ricardo Carrion at the
   Southwest Foundation for Biomedical Research (San Antonio, Texas) is
   highly appreciated.
NR 22
TC 30
Z9 31
U1 0
U2 26
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0304-8608
EI 1432-8798
J9 ARCH VIROL
JI Arch. Virol.
PD MAR
PY 2011
VL 156
IS 3
BP 489
EP 494
DI 10.1007/s00705-010-0847-1
PG 6
WC Virology
SC Virology
GA 726TM
UT WOS:000287749100015
PM 21104283
ER

PT J
AU Friedman, BE
   Lathi, RB
   Henne, MB
   Fisher, SL
   Milki, AA
AF Friedman, Brooke E.
   Lathi, Ruth B.
   Henne, Melinda B.
   Fisher, Stephanie L.
   Milki, Amin A.
TI The effect of air bubble position after blastocyst transfer on pregnancy
   rates in IVF cycles
SO FERTILITY AND STERILITY
LA English
DT Article
DE Blastocyst transfer; air bubble position; pregnancy rates
ID IN-VITRO FERTILIZATION; EMBRYO-TRANSFER; UTERINE CAVITY; TRANSFER
   CATHETER; IMPLANTATION; DEPTH; REPLACEMENT; IMPACT
AB Objective: To investigate the relationship between air bubble position after blastocyst transfer (BT) and pregnancy rates (PRs).
   Design: Retrospective cohort study.
   Setting: University-based infertility center.
   Patient(s): Three hundred fifteen consecutive nondonor BTs by a single provider.
   Intervention(s): Catheters were loaded with 25 mu L of culture media, 20 mu L of air, 25 mu L of media containing the blastocysts, 20 mu L of air, and a small amount of additional media. The distance from the air bubble to the fundus, as seen on abdominal ultrasound examination, was measured at the time of transfer. Air bubble location was categorized as <10 mm, 10-20 mm, and >20 mm from the fundus.
   Main Outcome Measure(s): Clinical pregnancy rate.
   Result(s): After controlling for age, parity, FSH and frozen transfers, and accounting for repeated cycles per patient, the PRs for both the >20-mm (38.3%) and the 10-20-mm (42.0%) from the fundus group were significantly reduced compared with the group in which the bubble was <10 mm from the fundus (62.5%).
   Conclusion(s): This study is the first to suggest that BT closer to the fundus is associated with higher PR. Although no ectopic pregnancies occurred in the <10-mm group, this outcome should be monitored closely in larger studies. (Fertil Steril (R) 2011; 95: 944-7. (C) 2011 by American Society for Reproductive Medicine.)
C1 [Friedman, Brooke E.; Lathi, Ruth B.; Milki, Amin A.] Stanford Fertil & Reprod Med Ctr, Palo Alto, CA 94304 USA.
   [Fisher, Stephanie L.] Stanford Univ, Med Ctr, Dept Obstet & Gynecol, Palo Alto, CA 94304 USA.
   [Henne, Melinda B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Friedman, BE (reprint author), Stanford Fertil & Reprod Med Ctr, 900 Welch Rd,Suite 350, Palo Alto, CA 94304 USA.
EM Brookef1@Stanford.edu
NR 19
TC 14
Z9 14
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
J9 FERTIL STERIL
JI Fertil. Steril.
PD MAR
PY 2011
VL 95
IS 3
BP 944
EP 947
DI 10.1016/j.fertnstert.2010.07.1063
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 723BD
UT WOS:000287480300019
PM 20810105
ER

PT J
AU Chen, X
   Yu, ZZA
   Hoyos, S
   Sadler, BM
   Silva-Martinez, J
AF Chen, Xi
   Yu, Zhuizhuan
   Hoyos, Sebastian
   Sadler, Brian M.
   Silva-Martinez, Jose
TI A Sub-Nyquist Rate Sampling Receiver Exploiting Compressive Sensing
SO IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
LA English
DT Article
DE Analog-to-information converters; compressive sensing (CS); low-noise
   analog circuits; low-power circuits; RF current mode circuits;
   sub-Nyquist analog-to-digital conversion (ADC); wideband receiver
ID COGNITIVE RADIO; WIRELESS COMMUNICATIONS; CMOS; CONVERSION; CIRCUITS;
   DESIGN; ADC
AB This paper presents a sub-Nyquist rate sampling receiver architecture that exploits signal sparsity by employing compressive sensing (CS) techniques. The receiver serves as an analog-to-information conversion system that works at sampling rates much lower than the Nyquist rate. A parallel-path structure that employs current mode sampling techniques is used. The receiver performance is quantified analytically. Useful and fundamental design guidelines that are unique to CS are provided based on the analytical tools. Simulations with a 90-nm CMOS process verify the theoretical derivations and the circuit implementations. Based on these results, it is shown that an instantaneous receiver signal bandwidth of 1.5 GHz and a signal-to-noise-plus-distortion ratio of 44 dB are achievable. The receiver power consumption is estimated to be 120.8 mW. A comparison with state-of-the-art high-speed analog-to-digital conversions reveals that the proposed approach improves the figure of merit by a factor of three if the signal exhibits a 4% sparsity.
C1 [Chen, Xi; Yu, Zhuizhuan; Hoyos, Sebastian; Silva-Martinez, Jose] Texas A&M Univ, Analog & Mixed Signal Ctr, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
   [Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Chen, X (reprint author), Texas A&M Univ, Analog & Mixed Signal Ctr, Dept Elect & Comp Engn, College Stn, TX 77843 USA.
EM berlaniontamu@neo.tamu.edu; zyu@neo.tamu.edu; hoyos@mail.ece.tamu.edu;
   bsadler@arl.army.mil; jsilva@mail.ece.tamu.edu
RI Yu, Zhuizhuan/B-7042-2014
FU Defense Advanced Research Projects Agency [W911NF-08-2-0047]; Army
   Research Laboratory Cooperative Technology Alliance [DAAD-19-01-2-0011]
FX Manuscript received October 14, 2009; revised February 23, 2010 and May
   14, 2010; accepted June 30, 2010. Date of publication December 30, 2010;
   date of current version February 24, 2011. This work was supported in
   part by the Defense Advanced Research Projects Agency under the
   Analog-to-Information Receiver Development Program (Army Research
   Laboratory Cooperative Agreement no. W911NF-08-2-0047) and in part by
   the Army Research Laboratory Cooperative Technology Alliance under
   Contract DAAD-19-01-2-0011. This paper was recommended by Associate
   Editor Y. Massoud.
NR 30
TC 30
Z9 32
U1 1
U2 11
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1549-8328
J9 IEEE T CIRCUITS-I
JI IEEE Trans. Circuits Syst. I-Regul. Pap.
PD MAR
PY 2011
VL 58
IS 3
BP 507
EP 520
DI 10.1109/TCSI.2010.2072430
PG 14
WC Engineering, Electrical & Electronic
SC Engineering
GA 725QF
UT WOS:000287660000007
ER

PT J
AU Garcia, RD
   Brown, A
AF Garcia, Richard D.
   Brown, Ainsmar
TI Control and Limitations of Navigating a Tail Rotor/Actuator Failed
   Unmanned Helicopter
SO JOURNAL OF INTELLIGENT & ROBOTIC SYSTEMS
LA English
DT Article
DE Helicopter reliability; Safety; Helicopter control
AB According to Federal Aviation Administration (FAA) statistics on mechanical failures, tail rotor failure is the third highest cause of fatal accidents in helicopters. Tail rotor failure represents a serious hazard to personnel and mission objectives and can create high fiscal loss. This is especially true for unmanned helicopters, which cannot be equipped with the fail-safes standard on manned counterparts. This work provides an overview of how a helicopter can be controlled after a tail rotor failure and its applicability to both manned and unmanned vehicles. This work specifically details some of the limitations of this type of software failure control.
C1 [Garcia, Richard D.] Motile Robot Inc, Joppa, MD 21085 USA.
   [Brown, Ainsmar] USA, Res Lab, Aberdeen, MD 21005 USA.
RP Garcia, RD (reprint author), Motile Robot Inc, Joppa, MD 21085 USA.
EM richard.garcia@motilerobotics.com; ainsmar.brown@arl.army.mil
NR 8
TC 1
Z9 1
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-0296
J9 J INTELL ROBOT SYST
JI J. Intell. Robot. Syst.
PD MAR
PY 2011
VL 61
IS 1-4
SI SI
BP 5
EP 13
DI 10.1007/s10846-010-9512-x
PG 9
WC Computer Science, Artificial Intelligence; Robotics
SC Computer Science; Robotics
GA 714AC
UT WOS:000286778100002
ER

PT J
AU Kragh, JF
   Wade, CE
   Baer, DG
   Jones, JA
   Walters, TJ
   Hsu, JR
   Wenke, JC
   Blackbourne, LH
   Holcomb, JB
AF Kragh, John F., Jr.
   Wade, Charles E.
   Baer, David G.
   Jones, John A.
   Walters, Thomas J.
   Hsu, Joseph R.
   Wenke, Joseph C.
   Blackbourne, Lorne H.
   Holcomb, John B.
TI Fasciotomy Rates in Operations Enduring Freedom and Iraqi Freedom:
   Association with Injury Severity and Tourniquet Use
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE hemorrhage control; compartment syndrome; ischemia; reperfusion;
   resuscitation
ID BURNED MILITARY CASUALTIES; COMPARTMENT SYNDROME; FLUID RESUSCITATION;
   SURVIVAL; OUTCOMES; WOUNDS; TRAUMA; SCORE; CARE
AB Objective: To compare fasciotomy rates and Injury Severity Scores (ISSs) before and after tourniquets were fielded for combat casualties in March 2005.
   Methods: A military trauma registry was used to identify 4332 casualties with limb injury between 2003 and 2006. Descriptive statistics and regression analysis were used to compare changes in ISSs, limb Abbreviated Injury Scale (AIS) scores, and fasciotomy rates. An item of specific interest was whether changes in fasciotomy rates occurred before and after March 2005, when tourniquets were fielded. Therefore, this time point served as a specific comparator in the statistical analyses.
   Results: Among the 4332 limb casualties, 669 (15%) underwent fasciotomy. The ISS doubled (100% increase) during the study. Limb AIS increased 35%. The increase in limb AIS constituted most of the increase in ISS. Monthly fasciotomy rates increased 500%(5% to 30%) during the study. When controlling injury severity (both AIS and ISS), fasciotomy rates tripled (200% increase); but when comparing fasciotomy before and after tourniquet fielding by AIS and ISS, rates only doubled (100% increase). On logistic regression for predicting fasciotomy, the model was unable to determine a good fit for the data because the variables were not significant except weakly for injury severity.
   Conclusions: During the period of the study, fasciotomy rates increased as a result of a combination of factors: increasing injury severity, increasing use of tourniquets, and increased awareness of the need to perform prophylactic fasciotomy. Further research should be aimed at determining what the optimum rate of fasciotomy is in such an environment.
C1 [Kragh, John F., Jr.; Wade, Charles E.; Baer, David G.; Jones, John A.; Walters, Thomas J.; Hsu, Joseph R.; Wenke, Joseph C.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Holcomb, John B.] Univ Texas Houston, Sch Med, Houston, TX USA.
RP Kragh, JF (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611,Room 282-4, Ft Sam Houston, TX 78234 USA.
EM john.kragh1@us.army.mil
FU Department of Defense; KCI
FX Dr. Kragh is an employee of the US Government and has consulted at no
   cost with Composite Resources Inc, Delfi Medical Innovations Inc, North
   American Rescue Products LLC, H & H Associates Inc, Blackhawk Products
   Group, and Hemaclear. He has received honoraria for work for the Food
   and Drug Administration and for the nonprofit Musculoskeletal Transplant
   Foundation. Dr. Kragh has no other financial disclosures that might
   relate to the manuscript. He has no financial involvement with companies
   that directly compete with products in the manuscript. Dr. Wenke is an
   employee of the US Government and has had grant support from the
   Department of Defense. He has received funds from KCI in direct support
   to do a study. Smith & Nephew has allowed Dr. Wenke to borrow medical
   devices. Dr. Wenke has no other financial disclosures that might relate
   to the manuscript. He has no financial involvement with companies that
   directly compete with products in the manuscript. Authors Wade, Baer,
   Walters, Hsu, Jones, Holcomb, and Blackbourne have no conflicts of
   interest. They report no financial disclosures that might relate to the
   manuscript.
NR 26
TC 13
Z9 13
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0890-5339
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD MAR
PY 2011
VL 25
IS 3
BP 134
EP 139
DI 10.1097/BOT.0b013e3181e52333
PG 6
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA 721LA
UT WOS:000287354500014
PM 21321506
ER

PT J
AU Kennedy, AJ
   Vasudevan, R
   Pappas, DD
   Weiss, CA
   Hendrix, SH
   Baney, RH
AF Kennedy, Alan J.
   Vasudevan, Ravikumar
   Pappas, Daphne D.
   Weiss, Charles A.
   Hendrix, Sara H.
   Baney, Ronald H.
TI Efficacy of non-toxic surfaces to reduce bioadhesion in terrestrial
   gastropods
SO PEST MANAGEMENT SCIENCE
LA English
DT Article
DE biomimic; gastropod; invasive species; adhesion control
ID ENGINEERED ANTIFOULING MICROTOPOGRAPHIES; ARIOLIMAX-COLUMBIANUS; PEDAL
   MUCUS; ALGA ULVA; COATINGS; ZOOSPORES; ADHESIVE; ATTACHMENT; SETTLEMENT;
   BEHAVIOR
AB BACKGROUND: Invasive species are described as the greatest threat to biodiversity, after habitat destruction and climate change, potentially imposing economic impacts and indigenous species impairment. Commonly applied chemical controls present the potential for legacy contamination and non-target organism injury. This study investigated the effects of different substrates and novel topographical surfaces on the behavioral and mechanical associations of the terrestrial gastropod Otala lactea.
   RESULTS: The gastropod preferentially aestivated on rough glass (61% increase, P < 0.01) relative to smooth glass but avoided a cross-patterned surface tessellation on silicone (82% reduction, P < 0.01) relative to smooth silicone. Significant deviations in turning behavior were found on the cross-patterned topographical surface and hydrophobic Teflon surfaces. The strongest correlation with gastropod adhesion strength to surfaces was found for surface elastic modulus (R = 0.88, P = 0.03), followed by hydrophobicity (R = 0.71, P = 0.14), but no relationship with roughness (P = 0.36).
   CONCLUSION: Preliminary data suggest surface roughness controlled aestivation behavior while elastic modulus (surface flexibility) controlled adhesion strength. In spite of greater adhesion to high-modulus materials, surface modulus was not a statistically significant controlling factor on gastropod aestivation preference. Understanding and exploiting the behavioral and mechanistic cues that organisms use while attaching to surfaces may lead to more environmentally benign control approaches. Published 2010 by John Wiley & Sons, Ltd.
C1 [Kennedy, Alan J.; Hendrix, Sara H.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
   [Vasudevan, Ravikumar; Baney, Ronald H.] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA.
   [Pappas, Daphne D.] USA, Res Lab, Aberdeen Proving Ground, MD USA.
   [Weiss, Charles A.] USA, Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS USA.
RP Kennedy, AJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
EM AlanJ.Kennedy@usace.army.mil
OI Pappas, Daphne/0000-0002-5746-8873
NR 43
TC 2
Z9 2
U1 2
U2 16
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 1526-498X
J9 PEST MANAG SCI
JI Pest Manag. Sci.
PD MAR
PY 2011
VL 67
IS 3
BP 318
EP 327
DI 10.1002/ps.2068
PG 10
WC Agronomy; Entomology
SC Agriculture; Entomology
GA 725XK
UT WOS:000287680000009
PM 21308957
ER

PT J
AU Paul, MA
   Gray, GW
   Lieberman, HR
   Love, RJ
   Miller, JC
   Trouborst, M
   Arendt, J
AF Paul, Michel A.
   Gray, Gary W.
   Lieberman, Harris R.
   Love, Ryan J.
   Miller, James C.
   Trouborst, Matthew
   Arendt, Josephine
TI Phase advance with separate and combined melatonin and light treatment
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Jet lag; Dim light melatonin onset; Circadian phase shift; Circadian
   desynchrony; Shift work
ID WESTWARD TRAVEL PREPARATION; BRIGHT LIGHT; JET-LAG; PLASMA MELATONIN;
   RESPONSE CURVE; CIRCADIAN-RHYTHMS; EASTWARD FLIGHT; SHIFT WORK; SLEEP;
   REENTRAINMENT
AB Melatonin and light treatment are recommended for hastening adaptation to time zone change. We evaluated an afternoon regimen of 3 mg sustained release (SR) melatonin with and without next morning green light treatment for circadian phase advance. Effects of melatonin and light were tested separately and then combined to determine if the total phase change is additive or synergistic.
   For each condition (melatonin, placebo, light, melatonin plus light), 11 subjects spent from Tuesday evening until Friday afternoon in the laboratory. For all four conditions, the following sleep schedule was maintained: night 1, 2345 to 0630 hours, night 2, 1600 to 0530 hours, and night 3, 2345 to 0700 hours. For the light-only condition, light treatment was administered between 0700 and 0800 hours on Thursday. For melatonin-only or placebo conditions, capsules were administered at 1600 hours on Wednesday. For the combined condition, melatonin was administered at 1600 hours on Wednesday with light treatment between 0600 and 0700 hours on Thursday. Circadian phase was assessed by calculating dim light melatonin onset (DLMO) from salivary melatonin, using a mean baseline +2 standard deviations (BL + 2 SD) threshold. For all four conditions, pre-treatment and post-treatment DLMO assessments were on Tuesday and Thursday evenings, respectively.
   Phase advances were: melatonin at 1600 hours, 0.72 h p < 0.005, light treatment from 0700 to 0800 hours, 0.31 h, non-significant, and the combined treatment, 1.04 h p < 0.0002.
   The phase advance from the combination of afternoon melatonin with next morning light is additive.
C1 [Paul, Michel A.; Gray, Gary W.] Def Res & Dev Canada, Toronto, ON M3M 3B9, Canada.
   [Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA.
   [Love, Ryan J.] McMaster Univ, Sch Biomed Engn, Hamilton, ON, Canada.
   [Miller, James C.] Millergonomics, San Antonio, TX USA.
   [Trouborst, Matthew] Univ Waterloo, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada.
   [Arendt, Josephine] Univ Surrey, Fac Hlth & Med Sci, Ctr Chronobiol, Neuroendocrinol Grp, Guildford GU2 5XH, Surrey, England.
RP Paul, MA (reprint author), Def Res & Dev Canada, 1133 Sheppard Ave W,POB 2000, Toronto, ON M3M 3B9, Canada.
EM michel.paul@drdc-rddc.gc.ca
RI Love, Ryan/I-8597-2012; 
OI Love, Ryan/0000-0003-1759-2957; Miller, James/0000-0002-3897-8376
FU Canadian Forces
FX The views, opinions, and/or findings in this report are those of the
   authors and should not be construed as an official Defence Research &
   Development Canada (DRDC), Department of National Defence (DND) Canada,
   or U.S. Department of Defense (DoD) position, policy or decisions,
   unless so designated by other official documentation. Citations of
   commercial organizations and trade names in this report do not
   constitute an official DRDC, DND Canada, or U.S. DoD endorsement or
   approval of the products or services of these organizations. Funding for
   this research was provided by the Canadian Forces.
NR 37
TC 18
Z9 18
U1 1
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD MAR
PY 2011
VL 214
IS 2
BP 515
EP 523
DI 10.1007/s00213-010-2059-5
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 726XE
UT WOS:000287759500013
PM 21069516
ER

PT J
AU Oldenburg, EW
   Colotelo, AH
   Brown, RS
   Eppard, MB
AF Oldenburg, Eric W.
   Colotelo, Alison H.
   Brown, Richard S.
   Eppard, M. Brad
TI Holding of juvenile salmonids for surgical implantation of electronic
   tags: a review and recommendations
SO REVIEWS IN FISH BIOLOGY AND FISHERIES
LA English
DT Review
DE Holding; Telemetry; Stress; Surgical implantation; Metabolic scope
ID TROUT ONCORHYNCHUS-MYKISS; GASTRIC EVACUATION RATES; DIEL FEEDING
   CHRONOLOGY; TRUTTA L. SMOLTS; CHINOOK SALMON; ATLANTIC SALMON;
   RAINBOW-TROUT; SWIMMING PERFORMANCE; ACOUSTIC TRANSMITTERS; RADIO
   TRANSMITTERS
AB Many telemetry-based studies require that fish be sampled from the wild and then held both prior to and after the implantation of an electronic tag. However, the effects of such holding (or the lack thereof) have yet to be studied intensively. Pre-surgical holding often occurs to facilitate logistical needs of research projects and as an attempt to minimize negative physiological effects due to capture and handling stress. Further, post-surgical holding time and conditions greatly influence the physiological state of fish prior to being returned to the wild. This paper reviews pertinent studies pertaining to the effects of surgical holding on the behavior, physiology, and survival of fishes, with particular emphasis on juvenile salmonids. The effects of individual aspects of surgical holding such as handling, water quality, light conditions, holding density, metabolic scope, and duration of holding are reviewed. Recommendations regarding certain aspects of surgical holding are offered with a goal of reducing bias related to the surgical process.
C1 [Oldenburg, Eric W.; Colotelo, Alison H.; Brown, Richard S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
   [Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA.
RP Oldenburg, EW (reprint author), Pacific NW Natl Lab, Ecol Grp, MSIN K6-85,POB 999, Richland, WA 99352 USA.
EM eric.oldenburg@pnl.gov
FU US Army Corps of Engineers, Portland District; Battelle for the US
   Department of Energy [DE-AC05-76RL01830]
FX Funding for this review was provided by US Army Corps of Engineers,
   Portland District. We thank Andrew Gingerich, Eric Hockersmith, Andrea
   Currie and three anonymous reviewers for their comments on previous
   drafts. We appreciate the technical assistance of Jill Janak and Andrea
   Lebarge. The Pacific Northwest National Laboratory is operated by
   Battelle for the US Department of Energy under Contract
   DE-AC05-76RL01830.
NR 59
TC 5
Z9 5
U1 2
U2 22
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0960-3166
EI 1573-5184
J9 REV FISH BIOL FISHER
JI Rev. Fish. Biol. Fish.
PD MAR
PY 2011
VL 21
IS 1
SI SI
BP 35
EP 42
DI 10.1007/s11160-010-9186-2
PG 8
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 726WG
UT WOS:000287756700004
ER

PT J
AU Braue, EH
   Smith, KH
   Doxzon, BF
   Lumpkin, HL
   Clarkson, ED
AF Braue, Ernest H., Jr.
   Smith, Kelly H.
   Doxzon, Bryce F.
   Lumpkin, Horace L.
   Clarkson, Edward D.
TI Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin
   Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure
   Reduction Paste Against Chemical Warfare Agents, Part 1: Guinea pigs
   challenged with VX
SO CUTANEOUS AND OCULAR TOXICOLOGY
LA English
DT Article
DE decontamination; personnel decontamination; skin decontamination;
   delayed decontamination; barrier skin creams; Skin Exposure Reduction
   Paste Against Chemical Warfare Agents; chemical warfare agents; nerve
   agents; VX
ID PROTECTION; STAGEWISE
AB Methods: In all experiments, guinea pigs were close-clipped and given anesthesia. In the decontamination experiments, the animals were challenged with VX and decontaminated after a 2-minute delay for the standard procedure or at longer times for the delayed-decontamination experiments. Skin Exposure Reduction Paste Against Chemical Warfare Agents was applied as a thin coating (0.1 mm thick), allowed to dry for 15 minutes, and challenged with VX. After a 2-hour challenge, any remaining VX was blotted off the animal, but no additional decontamination was done. Positive control animals were challenged with VX in the same manner as the treated animals, except that they received no treatment. In addition, the positive control animals were always challenged with 5% VX in isopropyl alcohol (IPA) solution, whereas the treatment animals received either neat (undiluted) VX or 5% VX in IPA solution. All animals were observed during the first 4 hours and again at 24 hours after exposure for signs of toxicity and death. The protective ratio (PR, defined as the median lethal dose [LD(50)] of the treatment group divided by the LD(50) of the untreated positive control animals) was calculated from the probit dose--response curves established for each treatment group and nontreated control animals. Significance in this report was defined as p < .05.
   Results: In the standard 2-minute neat VX decontamination experiments, the calculated PRs for Reactive Skin Decontamination Lotion (RSDL), 0.5% bleach, 1% soapy water, and the M291 Skin Decontamination Kit (SDK) were 66, 17, 16, and 1.1, respectively. Reactive Skin Decontamination Lotion was by far the most effective decontamination product tested and was significantly better than any of the other products. Bleach and soapy water provided equivalent and good (PR > 5) protection. They were both significantly better than the M291 SDK. The M291 SDK did not provide significant protection compared with positive controls. In the neat VX delayed-decontamination experiments, the calculated LT(50) (the delayed-decontamination time at which 50% of the animals died in the test population following a 5-LD(50) challenge) values for RSDL, 0.5% bleach, and 1% soapy water were 31, 48, and 26 minutes, respectively. The results showed that SERPACWA provided significant, but modest (PR < 5), protection against neat VX, with a PR of 2.1.
   Conclusions: Several conclusions can be drawn from this study: 1) RSDL provided superior protection against VX compared with the other products tested; 2) 0.5% bleach and 1% soapy water were less effective than RSDL, but still provided good protection against VX; 3) the M291 SDK was the least effective decontamination product and did not provide significant protection against VX; 4) the agent was observed to streak when using the M291 SDK, and efficacy may improve if the agent is first blotted, followed by wiping with a new or clean part of the M291 SDK pad; 5) RSDL, 0.5% bleach, and 1% soapy water provided significant protection against a 5-LD(50) challenge of VX, even when decontamination was delayed for up to about 30 minutes; and 6) SERPACWA provided significant, but modest, protection against VX.
C1 [Braue, Ernest H., Jr.; Smith, Kelly H.; Doxzon, Bryce F.; Lumpkin, Horace L.; Clarkson, Edward D.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Braue, EH (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM ernest.braue@us.army.mil
NR 36
TC 14
Z9 15
U1 0
U2 14
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1556-9527
J9 CUTAN OCUL TOXICOL
JI Cutan. Ocul. Toxicol.
PD MAR
PY 2011
VL 30
IS 1
BP 15
EP 28
DI 10.3109/15569527.2010.515280
PG 14
WC Ophthalmology; Toxicology
SC Ophthalmology; Toxicology
GA 719ZG
UT WOS:000287249400003
PM 20942572
ER

PT J
AU Braue, EH
   Smith, KH
   Doxzon, BF
   Lumpkin, HL
   Clarkson, ED
AF Braue, Ernest H., Jr.
   Smith, Kelly H.
   Doxzon, Bryce F.
   Lumpkin, Horace L.
   Clarkson, Edward D.
TI Efficacy studies of Reactive Skin Decontamination Lotion, M291 Skin
   Decontamination Kit, 0.5% bleach, 1% soapy water, and Skin Exposure
   Reduction Paste Against Chemical Warfare Agents, Part 2: Guinea pigs
   challenged with soman
SO CUTANEOUS AND OCULAR TOXICOLOGY
LA English
DT Article
DE decontamination; personnel decontamination; skin decontamination;
   delayed decontamination; barrier skin creams; Skin Exposure Reduction
   Paste Against Chemical Warfare Agents; chemical warfare agents; nerve
   agents; soman
AB Methods: In all experiments, guinea pigs were close-clipped and given anesthesia. In the decontamination experiments, the animals were challenged with GD and decontaminated after a 2-minute delay for the standard procedure or at longer times for the delayed-decontamination experiments. Positive control animals were challenged with GD in the same manner as the treated animals, except that they received no treatment. All animals were observed during the first 4 hours and again at 24 hours after exposure for signs of toxicity and death. The protective ratio (PR, defined as the median lethal dose [LD(50)] of the treatment group divided by the LD(50) of the untreated positive control animals) was calculated from the derived probit dose--response curves established for each treatment group and nontreated control animals. SERPACWA was applied as a thin coating (0.1 mm thick), allowed to dry for 15 minutes, and challenged with GD. After a 2-hour challenge, any remaining GD was blotted off the animal, but no additional decontamination was done. Significance in this report is defined as p <.05. Neat (undiluted) GD was used to challenge all animals in these studies.
   Results: In the standard 2-minute GD decontamination experiments, the calculated PRs for RSDL, 0.5% bleach, 1% soapy water, and M291 SDK were 14, 2.7, 2.2, and 2.6, respectively. RSDL was by far the most effective decontamination product tested and significantly better than any of the other products. Bleach, soapy water, and the M291 SDK provided equivalent and modest protection. Since only RSDL provided at least good protection (PR > 5), it was the only decontamination product evaluated for delayed decontamination. In the GD delayed-decontamination experiments, the calculated LT(50) (the delayed-decontamination time at which 50% of the animals die in the test population following a 5-LD(50) challenge) value for RSDL was only 4.0 minutes.
   Conclusions: Several conclusions can be drawn from this study: 1) Reactive Skin Decontamination Lotion provided superior protection against GD compared with the other products tested; 2) The 0.5% bleach solution, the 1% soapy water solution, and the M291 SDK were less effective than RSDL, but still provided modest (2 < PR < 5) protection against GD; 3) Reactive Skin Decontamination Lotion, the best product tested, did not provide significant protection against GD when decontamination was delayed for more than 3 minutes; 4) Skin Exposure Reduction Paste Against Chemical Warfare Agents provided significant, but modest, protection against GD; 5) There was good correlation between using the rabbit model and the guinea pig model for decontamination efficacy evaluations; and 6) Soman (GD) is an agent of real concern because it is very difficult to decontaminate and the effects ofexposure are difficult to treat.
C1 [Braue, Ernest H., Jr.; Smith, Kelly H.; Doxzon, Bryce F.; Lumpkin, Horace L.; Clarkson, Edward D.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Braue, EH (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM ernest.braue@us.army.mil
NR 10
TC 7
Z9 7
U1 0
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1556-9527
J9 CUTAN OCUL TOXICOL
JI Cutan. Ocul. Toxicol.
PD MAR
PY 2011
VL 30
IS 1
BP 29
EP 37
DI 10.3109/15569527.2010.515281
PG 9
WC Ophthalmology; Toxicology
SC Ophthalmology; Toxicology
GA 719ZG
UT WOS:000287249400004
PM 20964500
ER

PT J
AU Cordier, C
   Folco, L
   Taylor, S
AF Cordier, Carole
   Folco, Luigi
   Taylor, Susan
TI Vestoid cosmic spherules from the South Pole Water Well and
   Transantarctic Mountains (Antarctica): A major and trace element study
SO GEOCHIMICA ET COSMOCHIMICA ACTA
LA English
DT Article
ID MARTIAN METEORITE; PARENT BODIES; CHONDRITIC METEORITES; MINERAL
   CHEMISTRY; ACCRETION RATE; SHERGOTTITE; OXYGEN; MICROMETEORITES;
   PETROLOGY; EUCRITES
AB We present major and trace element data of five glass cosmic spherules (CS) with differentiated compositions recovered in the South Pole Water Well and the Transantarctic Mountains, Antarctica. The differentiated CS were first identified using Fe/Mg and Fe/Mn ratios and we have now added high Rare Earth Element concentrations (5 < REE(N) < 14), and low siderophile element abundances (e.g. Ni = 25 +/- 27 ppm) as characteristics. We propose that the siderophile depletions observed in differentiated CS result from the segregation of these elements into the core of their parent body during differentiation. Then, the high Fe/Mg ratios of differentiated CS result from their low MgO contents. Combined with their high level of REE enrichment, this indicates that the precursors formed through basaltic melt extraction from the asteroid/planetary source. As Fe/Mn and Fe/Mg ratios cannot distinguish between a Martian or Vestoid origin, we measured trace elements (zinc, cobalt, and vanadium) whose chemical behavior depends on oxidation state, known to be higher in the Martian than in the Vestoid environment. The compositions of the differentiated CS studied in this work share the characteristics of eucrites for all these indicators, providing further evidence that these differentiated CS are samples of a Vesta-like asteroid. However, their precursors show a considerable diversity in their mineralogy when compared to eucrites, that results in a wider range of major (Ca and Al) and trace element (Ba, Sr, Sc, and V) composition in differentiated CS. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Cordier, Carole; Folco, Luigi] Univ Siena, Museo Nazl Antartide, I-53100 Siena, Italy.
   [Taylor, Susan] Cold Reg Res & Engn Lab CRREL, Hanover, NH 03755 USA.
RP Cordier, C (reprint author), Univ Siena, Museo Nazl Antartide, Via Laterina 8, I-53100 Siena, Italy.
EM cordier@unisi.it
OI Cordier, Carole/0000-0002-6100-4393
FU Programma Nazionale delle Ricerche in Antartide (PNRA); European Union
   [35519]
FX This work was supported by the Programma Nazionale delle Ricerche in
   Antartide (PNRA). CC and LF were also supported by the European Union
   through the Marie Curie Actions-RTNs ORIGINS Project (ID: 35519).
   Authors are grateful to Raul Carampin, Massimo Tiepolo, and Andrea
   Cavallo for their help during EPMA, LA-ICP-MS, and FEG-SEM analytical
   sessions, respectively. P. Buchanan and an anonymous reviewer are kindly
   acknowledged for their reviews, and C. Koeberl for editorial assistance.
NR 83
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Z9 20
U1 1
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0016-7037
J9 GEOCHIM COSMOCHIM AC
JI Geochim. Cosmochim. Acta
PD MAR 1
PY 2011
VL 75
IS 5
BP 1199
EP 1215
DI 10.1016/j.gca.2010.11.024
PG 17
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA 720OE
UT WOS:000287289200003
ER

PT J
AU Wegner, W
   Worner, G
   Harmon, RS
   Jicha, BR
AF Wegner, Wencke
   Woerner, Gerhard
   Harmon, Russell S.
   Jicha, Brian R.
TI Magmatic history and evolution of the Central American Land Bridge in
   Panama since Cretaceous times
SO GEOLOGICAL SOCIETY OF AMERICA BULLETIN
LA English
DT Article
ID OXYGEN-ISOTOPE FRACTIONATION; NORTHWESTERN SOUTH-AMERICA; BENEATH
   CENTRAL-AMERICA; LARGE IGNEOUS PROVINCE; COSTA-RICA; OCEANIC PLATEAU;
   WESTERN PANAMA; VOLCANIC-ROCKS; MANTLE PLUME; TECTONIC HISTORY
AB Chemical compositions for 310 igneous rocks from the Cordillera de Panama and the Sona and Azuero peninsulas were supplemented by (40)Ar/(39)Ar dating and Sr-, Nd-, Pb-, and O-isotope analysis to determine the magmatic evolution and oceanic plate inter actions over the past 100 Ma in western Panama. An initial phase of intraplate magmatism, having geochemical characteristics of the Galapagos hotspot, formed the oceanic basement of the Caribbean large igneous province from 139 to 69 Ma. Younger accreted terranes with enriched trace element patterns (accreted ocean island basalt [OIB]) were amalgamated between 70 and 20 Ma. A second magmatic phase in the Azuero and Sona peninsulas has trace element patterns (Sona-Azuero arc) suggesting the initiation of subduction at 71-69 Ma. Arc magmatism continued in the Chagres basin region (Chagres-Bayano arc) from 68 to 40 Ma. A third phase formed discrete volcanic centers across the Cordillera de Panama (Cordilleran arc) from 19 to 5 Ma. The youngest phase consists of isolated volcanic centers of adakitic composition (Adakite suite) in the Cordillera de Panama that developed over the past 2 million years.
   Initiation of arc magmatism at 71 Ma coincides with the cessation of Galapagos plateau formation, suggesting a causal link. The transition from intraplate to arc magmatism occurred relatively quickly and introduced a new enriched mantle source. The arc magmatism involved progressive transition to more homogeneous intermediate mantle wedge compositions through mixing and homogenization of subarc magma sources through time and/or the replacement of the mantle wedge by a homogeneous, relatively undeleted asthenospheric mantle. Adakite volcanism started after a magmatic gap, enabled by the formation of a slab window.
C1 [Wegner, Wencke; Woerner, Gerhard] Univ Gottingen, Geosci Ctr, Div Geochem, D-37077 Gottingen, Germany.
   [Harmon, Russell S.] USA, Res Lab, Army Res Off, Durham, NC 27703 USA.
   [Harmon, Russell S.] N Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
   [Jicha, Brian R.] Univ Wisconsin, Dept Geol & Geophys, Madison, WI 53706 USA.
RP Wegner, W (reprint author), Univ Gottingen, Geosci Ctr, Div Geochem, D-37077 Gottingen, Germany.
EM wwegner1@gwdg.de
FU Army Research Laboratory; Deutsche Forschungsgemeinschaft [WO 362/27-2]
FX We thank the following organizations and people for their logistical
   assistance and help in collection of samples across Panama from 2001 to
   2006: Thomas Exenberger and Thomas Jakits of Helipan Panama; Lance
   Vander Zyl of U.S. Army Yuma Proving Ground Tropic Regions Test Center;
   Eric Nicolaisen, Ricardo Martinez, and Alonso Iglesias of TRAX
   Evaluacion Ambiental, S.A. The Volcan Baru samples were collected and
   partially analyzed by S. Rausch as a part of her Master's thesis at
   Gottingen University. G. Hartmann, R. Przybilla, I. Reuber, I.
   Schonberg, and K. Simon assisted with geochemical and isotopic
   analytical work. We thank B. Hansen and A. Pack for access to the
   thermal ionization mass spectrometer and stable isotope laboratories.
   Financial support for the fieldwork came from an Army Research
   Laboratory fellow stipend to R. S. H. and from the Deutsche
   Forschungsgemeinschaft project WO 362/27-2 to G.W. Constructive comments
   by K. Hoernle and E. Gazel are greatly appreciated.
NR 95
TC 49
Z9 51
U1 1
U2 25
PU GEOLOGICAL SOC AMER, INC
PI BOULDER
PA PO BOX 9140, BOULDER, CO 80301-9140 USA
SN 0016-7606
J9 GEOL SOC AM BULL
JI Geol. Soc. Am. Bull.
PD MAR-APR
PY 2011
VL 123
IS 3-4
BP 703
EP 724
DI 10.1130/B30109.1
PG 22
WC Geosciences, Multidisciplinary
SC Geology
GA 712KJ
UT WOS:000286665300018
ER

PT J
AU Enquist, BJ
   Enquist, CAF
AF Enquist, Brian J.
   Enquist, Carolyn A. F.
TI Long-term change within a Neotropical forest: assessing differential
   functional and floristic responses to disturbance and drought
SO GLOBAL CHANGE BIOLOGY
LA English
DT Review
DE climate change; community ecology; drought; El Nino; long-term forest
   dynamics; Pacific Decadal Oscillation; Tropical dry forest
ID TROPICAL DRY-FOREST; GENERAL QUANTITATIVE THEORY; RAIN-FOREST;
   COSTA-RICA; CLIMATE-CHANGE; SPECIES DISTRIBUTIONS; HABITAT ASSOCIATIONS;
   AMAZONIAN FORESTS; CENTRAL-AMERICA; TREE TURNOVER
AB Disentangling the relative roles of biotic and abiotic forces influencing forest structure, function, and local community composition continues to be an important goal in ecology. Here, utilizing two forest surveys 20-year apart from a Central American dry tropical forest, we assess the relative role of past disturbance and local climatic change in the form of increased drought in driving forest dynamics. We observe: (i) a net decrease in the number of trees; (ii) a decrease in total forest biomass by 7.7 Mg ha-1 but when calculated on subquadrat basis the biomass per unit area did not change indicating scale sensitivity of forest biomass measures; (iii) that the decrease in the number of stems occurred mainly in the smallest sizes, and in more moist and evergreen habitats; (iv) that there has been an increase in the proportion of trees that are deciduous, compound leaved and are canopy species, and a concomitant reduction in trees that are evergreen, simple-leaved, and understory species. These changes are opposite to predictions based on recovery from disturbance, and have resulted in (v) a uniform multivariate shift from a more mesic to a more xeric forest. Together, our results show that over relatively short time scales, community composition and the functional dominance may be more responsive to climate change than recovery to past disturbances. Our findings point to the importance of assessing proportional changes in forest composition and not just changes in absolute numbers. Our findings are also consistent with the hypothesis that tropical tree species exhibit differential sensitivity to changes in precipitation. Predicted future decreases in rainfall may result in quick differential shifts in forest function, physiognomy, and species composition. Quantifying proportional functional composition offers a basis for a predictive framework for how the structure, and diversity of tropical forests will respond to global change.
C1 [Enquist, Brian J.] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA.
   [Enquist, Brian J.] Santa Fe Inst, Santa Fe, NM 87501 USA.
   [Enquist, Carolyn A. F.] Univ Arizona, Sch Nat Resources & Environm, Tucson, AZ 85721 USA.
   [Enquist, Carolyn A. F.] USA, Natl Phenol Network, Tucson, AZ 85719 USA.
   [Enquist, Carolyn A. F.] Wildlife Soc, Bethesda, MD 20814 USA.
RP Enquist, BJ (reprint author), Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA.
EM benquist@email.arizona.edu
OI Enquist, Brian/0000-0002-6124-7096
FU shoestring budget; Fulbright Fellowship; Nature Conservancy graduate
   student Fellowship; Tinker Foundation; University of New Mexico's SRAC;
   GRAC
FX We thank George C. Stevens and Steve P. Hubbell for allowing us to
   retrieve, revive, and resurvey the San Emilio plot. This project would
   not be possible if it were not for their vision, assistance and
   guidance. G. C. Stevens provided critical help with the original data
   retrieval and logistics associated with the remap. In addition, we are
   particularly indebted to: N. Zamora, D. H. Janzen, R. Blanco, M.
   Chavaria, A. Masis, C. Camargo, L. Rose, T. Gillispie, O. Espinoza, R.
   Franco, J. Klemens who provided logistical and botanical assistance. Our
   field assistant Leticia B. Brown assisted us in remapping the forest.
   Also, D. Sax, T. Keitt, C. Camargo, J. J. Sullivan, A. Masis, L. Brown,
   T. F. Wright, and D. Benitez also assisted in remapping the SEFDP and L.
   Rose T. Gillispie, A. Masis, J. J. Sullivan, L. Moles, D. Sax, 'Huesos,'
   and C. Camargo all provided much needed intellectual support. This
   manuscript benefited from comments from J. H. Brown, and M. Moles. Also,
   we wish to acknowledge the use of the facilities of the Instituto
   Nacional de Biodiversidad (INBIO), and the National Herbarium of Costa
   Rica for allowing us to access their specimens, and to the University of
   New Mexico (UNM) and University of Arizona Herbarium for assisting in
   mounting and databasing our specimen collections from the SEFDP. We
   thank the staff of Sector Santa Rosa for support and inspiration, most
   notably R. Blanco for logistically enabling our work. N. Swenson
   provided additional key support. This work was funded on a shoestring
   budget including a Fulbright Fellowship and a Nature Conservancy
   graduate student Fellowship to B. J. E. Funding from the Tinker
   Foundation and University of New Mexico's SRAC and GRAC supported both
   CAFE and B. J. E.
NR 121
TC 45
Z9 48
U1 5
U2 68
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1354-1013
J9 GLOBAL CHANGE BIOL
JI Glob. Change Biol.
PD MAR
PY 2011
VL 17
IS 3
BP 1408
EP 1424
DI 10.1111/j.1365-2486.2010.02326.x
PG 17
WC Biodiversity Conservation; Ecology; Environmental Sciences
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 714VU
UT WOS:000286837900013
ER

PT J
AU Bhattarai, R
   Kalita, PK
   Yatsu, S
   Howard, HR
   Svendsen, NG
AF Bhattarai, Rabin
   Kalita, Prasanta K.
   Yatsu, Shotaro
   Howard, Heidi R.
   Svendsen, Niels G.
TI Evaluation of compost blankets for erosion control from disturbed lands
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Environmental management; Runoff; Sediment; Soil
ID SOIL-EROSION; WATER-RETENTION; RUNOFF; RAINFALL; QUALITY; LOSSES; MULCH
AB Soil erosion due to water and wind results in the loss of valuable top soil and causes land degradation and environmental quality problems. Site specific best management practices (BMP) are needed to curb erosion and sediment control and in turn, increase productivity of lands and sustain environmental quality. The aim of this study was to investigate the effectiveness of three different types of biodegradable erosion control blankets-fine compost, mulch, and 50-50 mixture of compost and mulch, for soil erosion control under field and laboratory-scale experiments. Quantitative analysis was conducted by comparing the sediment load in the runoff collected from sloped and tilled plots in the field and in the laboratory with the erosion control blankets. The field plots had an average slope of 3.5% and experiments were conducted under natural rainfall conditions, while the laboratory experiments were conducted at 4, 8 and 16% slopes under simulated rainfall conditions. Results obtained from the field experiments indicated that the 50-50 mixture of compost and mulch provides the best erosion control measures as compared to using either the compost or the mulch blanket alone. Laboratory results under simulated rains indicated that both mulch cover and the 50-50 mixture of mulch and compost cover provided better erosion control measures compared to using the compost alone. Although these results indicate that the 50-50 mixtures and the mulch in laboratory experiments are the best measures among the three erosion control blankets, all three types of blankets provide very effective erosion control measures from bare-soil surface. Results of this study can be used in controlling erosion and sediment from disturbed lands with compost mulch application. Testing different mixture ratios and types of mulch and composts, and their efficiencies in retaining various soil nutrients may provide more quantitative data for developing erosion control plans. (c) 2010 Elsevier Ltd. All rights reserved.
C1 [Bhattarai, Rabin; Kalita, Prasanta K.; Yatsu, Shotaro] Univ Illinois, Dept Agr & Biol Engn, Urbana, IL 61801 USA.
   [Howard, Heidi R.; Svendsen, Niels G.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Kalita, PK (reprint author), Univ Illinois, Dept Agr & Biol Engn, 1304 W Penn Ave, Urbana, IL 61801 USA.
EM rbhatta2@illinois.edu; pkalita@illinois.edu
OI Bhattarai, Rabin/0000-0002-3433-299X
NR 28
TC 7
Z9 11
U1 4
U2 17
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD MAR
PY 2011
VL 92
IS 3
BP 803
EP 812
DI 10.1016/j.jenvman.2010.10.028
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 714BR
UT WOS:000286782400049
PM 21036461
ER

PT J
AU Oceguera-Figueroa, A
   Phillips, AJ
   Pacheco-Chaves, B
   Reeves, WK
   Siddall, ME
AF Oceguera-Figueroa, Alejandro
   Phillips, Anna J.
   Pacheco-Chaves, Bernald
   Reeves, Will K.
   Siddall, Mark E.
TI Phylogeny of macrophagous leeches (Hirudinea, Clitellata) based on
   molecular data and evaluation of the barcoding locus
SO ZOOLOGICA SCRIPTA
LA English
DT Article
ID ERPOBDELLA-OCTOCULATA HIRUDINEA; OXIDASE SUBUNIT-I; EVOLUTION; FAMILY;
   GENERA; ARHYNCHOBDELLIDA; OLIGOCHAETA; PRIMERS; WORLD; DIET
AB The phylogenetic relationships of macrophagous leech species are studied using two mitochondrial [cytochrome c oxidase subunit I (COI) and 12S rDNA] and two nuclear (28S rDNA and 18S rDNA) markers. The complete dataset analysed in this study included 49 terminals and 5540 aligned characters. Phylogenetic analyses were performed under two optimality criteria: Maximum Parsimony and Maximum Likelihood. The monophyly of the two currently recognized families (i.e. Erpobdellidae and Salifidae) is confirmed and well supported. The phylogenetic position of Gastrostomobdellidea is studied for the first time and found to be sister to family Salifidae nested well within Erpobdelliformes. Previously recognized taxonomic arrangements were evaluated and discarded through successive constraint analyses. Correlation between morphology and phylogeny was notable in Salifidae but not in Erpobdellidae. Variability of COI, the barcoding locus, was examined across species leading to the recognition of the invasive Barbronia weberi in Mexico, Costa Rica, Germany, South Africa and Taiwan.
C1 [Oceguera-Figueroa, Alejandro; Phillips, Anna J.] Amer Museum Nat Hist, Div Invertebrate Zool, New York, NY 10024 USA.
   [Oceguera-Figueroa, Alejandro; Phillips, Anna J.] CUNY, Grad Ctr, Dept Biol, New York, NY 10024 USA.
   [Pacheco-Chaves, Bernald] Univ Costa Rica, Escuela Biol, San Jose 115012060, Costa Rica.
   [Reeves, Will K.] USA, Publ Hlth Command Reg, Pacific Unit 45006, Mchb Aj Tld Apo, AP 96343 USA.
   [Reeves, Will K.] US Army Japan, Publ Hlth Command, Okinawa, Japan.
   [Siddall, Mark E.] Amer Museum Nat Hist, Sackler Inst Comparat Genom, New York, NY 10024 USA.
RP Oceguera-Figueroa, A (reprint author), Amer Museum Nat Hist, Div Invertebrate Zool, Cent Pk W & 79th St, New York, NY 10024 USA.
EM aoceguera@amnh.org; ajphillips@amnh.org; bernald.pacheco@gmail.com;
   will.reeves@us.army.mil; siddall@amnh.org
OI Phillips, Anna/0000-0003-4883-0022
FU National Science Foundation [DEB 0640436]; CONACyT, Mexico; Theodore
   Roosevelt Memorial Grant (AMNH); Graduate Center Science Fellowship
   (CUNY)
FX This project was supported by the National Science Foundation (DEB
   0640436). AOF thanks CONACyT, Mexico, the Theodore Roosevelt Memorial
   Grant (AMNH) and the Graduate Center Science Fellowship (CUNY) for
   financial support. Thanks to the Willi Hennig Society for making TNT
   freely available. Sebastian Kvist, Colleen Ingram and Maria Teresa
   Aguado provided important commentaries on early versions of this paper.
   Lorenzo Prendini, Wayne Van Devender, Rex Vanderford, Chris Obrien,
   Daniel Munana and Leonard Kalihangabo collected leech specimens
   presented in this paper. Jethro Edubagwa Odanga (College of Conservation
   and Environmental Management), Francois Bizimungu (Rwanda Office of
   Tourism and National Parks), Tony Mudakikwa (Vet-Unit Manager and Cites
   Scientific Authority, ORTPN) and Rosette Chantal Rugamba (General
   Director, ORTPN) provided logistic support during field-work in Rwanda.
NR 51
TC 15
Z9 16
U1 2
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0300-3256
J9 ZOOL SCR
JI Zool. Scr.
PD MAR
PY 2011
VL 40
IS 2
BP 194
EP 203
DI 10.1111/j.1463-6409.2010.00465.x
PG 10
WC Evolutionary Biology; Zoology
SC Evolutionary Biology; Zoology
GA 722AR
UT WOS:000287401700007
ER

PT J
AU Goodin, JL
   Powell, BS
   Enama, JT
   Raab, RW
   McKown, RL
   Coffman, GL
   Andrews, GP
AF Goodin, Jeremy L.
   Powell, Bradford S.
   Enama, Jeff T.
   Raab, Ronald W.
   McKown, Robert L.
   Coffman, George L.
   Andrews, Gerard P.
TI Purification and characterization of a recombinant Yersinia pestis V-F1
   "Reversed" fusion protein for use as a new subunit vaccine against
   plague
SO PROTEIN EXPRESSION AND PURIFICATION
LA English
DT Article
DE Yersinia pestis; Vaccine; F1-V; F1S-V-F1; caf1
ID PERIPLASMIC CHAPERONE CAF1M; ESCHERICHIA-COLI; PNEUMONIC PLAGUE;
   SALMONELLA-TYPHIMURIUM; F1 ANTIGEN; SURFACE; EXPRESSION; PROTECTION;
   DISPLAY; BIOGENESIS
AB We previously developed a unique recombinant protein vaccine against plague composed of a fusion between the Fraction 1 capsular antigen (F1) and the V antigen. To determine if overall expression, solubility, and recovery of the F1-V fusion protein could be enhanced, we modified the original fusion. Standard recombinant DNA techniques were used to reverse the gene order such that the V antigen coding sequence was fused at its C-terminus to the N-terminus of F1. The F1 secretion signal sequence (F1S) was subsequently fused to the N-terminus of V. This new fusion protein, designated F1S-V-F1, was then co-expressed with the Y. pestis Caf1M periplasmic chaperone protein in BL21-Star Escherichia coli. Recombinant strains expressing F1-V. F1S-F1-V, or F1S-V-F1 were compared by cell fractionation, SDS-PAGE, Western blotting, and suspension immunolabelling. F1S-V-F1 exhibited enhanced solubility and secretion when co-expressed with Caf1M resulting in a recombinant protein that is processed in a similar manner to the native F1 protein. Purification of F1S-V-F1 was accomplished by anion-exchange and hydrophobic interaction chromatography. The purification method produced greater than 1 mg of purified soluble protein per liter of induced culture. F1S-V-F1 polymerization characteristics were comparable to the native F1. The purified F1S-V-F1 protein appeared equivalent to F1-V in its ability to be recognized by neutralizing antibodies. Published by Elsevier Inc.
C1 [Goodin, Jeremy L.; Powell, Bradford S.; Enama, Jeff T.] US Army, Bacteriol Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
   [Raab, Ronald W.; McKown, Robert L.; Coffman, George L.] James Madison Univ, Dept Integrated Sci & Technol, Harrisonburg, VA 22807 USA.
   [Andrews, Gerard P.] Univ Wyoming, Dept Vet Sci, Laramie, WY 82070 USA.
RP Goodin, JL (reprint author), DD Eisenhower Army Med Ctr, Dept Clin Invest, BLDG 38705, Ft Gordon, GA 30905 USA.
EM jeremy.goodin@amedd.army.mil
FU USAMRIID [403-4-5A-013]; James Madison University
FX The authors wish to thank Dale Isaak for his critical review with this
   manuscript, and Jessie Payne for her administrative assistance. The
   research described herein was sponsored by USAMRIID project
   #03-4-5A-013, and a Cooperative Research and Development Agreement
   (CRADA) between the U.S. Army Medical Research Institute for Infectious
   Diseases and James Madison University.
NR 30
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Z9 3
U1 1
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-5928
J9 PROTEIN EXPRES PURIF
JI Protein Expr. Purif.
PD MAR
PY 2011
VL 76
IS 1
BP 136
EP 144
DI 10.1016/j.pep.2010.10.011
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 705WH
UT WOS:000286170900020
PM 21055471
ER

PT J
AU Levin, GA
   Jones, WA
   Novak, KA
   Barnes, PN
AF Levin, G. A.
   Jones, W. A.
   Novak, K. A.
   Barnes, P. N.
TI The effects of superconductor-stabilizer interfacial resistance on
   quenching of a pancake coil made out of coated conductor
SO SUPERCONDUCTOR SCIENCE & TECHNOLOGY
LA English
DT Article
AB We present the results of numerical analysis of normal zone propagation in a stack of YBa(2)Cu(3)O(7-x) coated conductors which imitates a pancake coil. Our main purpose is to determine whether the quench protection quality of such coils can be substantially improved by increased contact resistance between the superconducting film and the stabilizer. We show that with increased contact resistance the speed of normal zone propagation increases, the detection of a normal zone inside the coil becomes possible earlier, when the peak temperature inside the normal zone is lower, and stability margins shrink. Thus, increasing contact resistance may become a viable option for improving the prospects of coated conductors for high T(c) magnet applications.
C1 [Levin, G. A.; Jones, W. A.; Barnes, P. N.] USAF, Res Lab, Prop Directorate, Wright Patterson AFB, OH 45433 USA.
   [Novak, K. A.] USAF, Inst Technol, Dept Math, Wright Patterson AFB, OH 45433 USA.
   [Barnes, P. N.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Levin, GA (reprint author), USAF, Res Lab, Prop Directorate, Wright Patterson AFB, OH 45433 USA.
FU Air Force Office of Scientific Research
FX This work was supported in part by an Air Force Office of Scientific
   Research contract.
NR 15
TC 9
Z9 9
U1 1
U2 4
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 0953-2048
J9 SUPERCOND SCI TECH
JI Supercond. Sci. Technol.
PD MAR
PY 2011
VL 24
IS 3
AR 035015
DI 10.1088/0953-2048/24/3/035015
PG 10
WC Physics, Applied; Physics, Condensed Matter
SC Physics
GA 709FF
UT WOS:000286422600016
ER

PT J
AU Bode, DV
   Roberts, TA
AF Bode, David V.
   Roberts, Timothy A.
TI Self-Injurious Behavior in an Adolescent
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Editorial Material
ID COMMUNITY SAMPLE; SUICIDE; WOMEN; ABUSE
C1 [Bode, David V.; Roberts, Timothy A.] Brooke Army Med Ctr, Div Adolescent Med, Ft Sam Houston, TX 78234 USA.
RP Bode, DV (reprint author), Brooke Army Med Ctr, Div Adolescent Med, Ft Sam Houston, TX 78234 USA.
EM dave.bode@us.army.mil
NR 13
TC 0
Z9 0
U1 0
U2 1
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAR 1
PY 2011
VL 83
IS 5
BP 609
EP 611
PG 3
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 979ZG
UT WOS:000306862800016
PM 21391529
ER

PT J
AU Miettinen, M
   Wang, ZF
   Paetau, A
   Tan, SH
   Dobi, A
   Srivastava, S
   Sesterhenn, I
AF Miettinen, Markku
   Wang, Zeng-Feng
   Paetau, Anders
   Tan, Shyh-Han
   Dobi, Albert
   Srivastava, Shiv
   Sesterhenn, Isabell
TI ERG Transcription Factor as an Immunohistochemical Marker for Vascular
   Endothelial Tumors and Prostatic Carcinoma
SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY
LA English
DT Article
DE ETS-family transcription factor; ERG; angiosarcoma;
   hemangioendothelioma; hemangioma; immunohistochemistry; prostate
   carcinoma
ID ACUTE MYELOID-LEUKEMIA; MONOCLONAL-ANTIBODY; EXPRESSION; CELL;
   DIAGNOSIS; CANCER; CD34; GENE; OVEREXPRESSION; ANGIOSARCOMAS
AB ERG, an ETS family transcription factor, is known to be expressed in endothelial cells, and oncogenic ERG gene fusions occur in subsets of prostatic carcinoma, acute myeloid leukemia, and Ewing sarcoma. In this study, we immunohistochemically investigated nuclear ERG expression using a new monoclonal antibody, CPDR ERG-MAb, that is highly specific for detecting ERG protein and ERG-expressing prostate carcinomas. A broad range of vascular endothelial (n = 250), other mesenchymal (n = 973), and epithelial tumors (n = 657) was examined to determine the use of ERG immunohistochemistry in surgical pathology. Only immunostains with ERG-positive normal endothelia (internal control) were considered valid, and only nuclear staining was considered to be positive. In adult tissues, ERG was restricted to endothelial cells and to a subset of bone marrow precursors, but early fetal mesenchyme and subpopulations of fetal cartilage were also positive. In vascular tumors, ERG was expressed in endothelia of all hemangiomas and lymphangiomas, and typically extensively expressed in 96 of 100 angiosarcomas, 42 of 43 epithelioid hemangioendotheliomas, and all 26 Kaposi sarcomas. Among nonvascular mesenchymal tumors, only blastic extramedullary myeloid tumors (7 of 10) and rare Ewing sarcomas (2 of 29) were positive. Among epithelial tumors, 30 of 66 prostatic adenocarcinomas showed focal-to-extensive ERG positivity, with no immunoreactivity in the normal prostate. Other carcinomas and epithelial tumors (n= 643) were ERG negative, with the exception of 1 of 42 large cell undifferentiated pulmonary carcinomas and 1 of 27 mesotheliomas, each of which showed focal nuclear ERG positivity. On the basis of the above observations, ERG is a highly specific new marker for benign and malignant vascular tumors. Among epithelial tumors, ERG shows a great promise as a marker to identify prostatic carcinoma in both primary and metastatic settings.
C1 [Miettinen, Markku; Wang, Zeng-Feng; Sesterhenn, Isabell] Armed Forces Inst Pathol, Washington, DC 20306 USA.
   [Tan, Shyh-Han; Dobi, Albert; Srivastava, Shiv] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC USA.
   [Tan, Shyh-Han; Dobi, Albert; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Rockville, MD USA.
   [Paetau, Anders] Helsinki Univ Hosp, Helsinki, Finland.
RP Miettinen, M (reprint author), Armed Forces Inst Pathol, 6825 16th St,NW Bldg 54,Rm G090, Washington, DC 20306 USA.
EM miettinen@afip.osd.mil
RI Tan, Shyh-Han/I-7037-2013
OI Tan, Shyh-Han/0000-0001-8250-7005
NR 33
TC 124
Z9 129
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0147-5185
J9 AM J SURG PATHOL
JI Am. J. Surg. Pathol.
PD MAR
PY 2011
VL 35
IS 3
BP 432
EP 441
DI 10.1097/PAS.0b013e318206b67b
PG 10
WC Pathology; Surgery
SC Pathology; Surgery
GA 722OD
UT WOS:000287441200014
PM 21317715
ER

PT J
AU Roach, MJ
   Harrington, A
   Powell, H
   Nemunaitis, G
AF Roach, Mary Joan
   Harrington, Amanda
   Powell, Heather
   Nemunaitis, Gregory
TI Cell Telephone Ownership and Social Integration in Persons With Spinal
   Cord Injury
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Article
DE Cell telephones; Rehabilitation; Spinal cord injuries; Social
   interaction; Technology
ID WIRELESS TECHNOLOGIES; MOBILE PHONES; INTERNET USE; REHABILITATION;
   DISABILITIES; PEOPLE
AB Objectives: To describe the prevalence and demographic characteristics associated with cell telephone ownership and to investigate whether cell telephone ownership has a positive relationship with social integration.
   Design: Cross-sectional.
   Setting: Spinal Cord Injury (SCI) Model Systems.
   Participants: Participants (N=7696) with traumatic SCI who were entered into the National SCI Database and completed a follow-up interview from April 2004 through April 2009.
   Interventions: None.
   Main Outcome Measures: Cell telephone ownership; Craig Handicap Assessment Reporting Technique Social Integration subscale.
   Results: A total of 73% of participants owned a cell telephone. Persons who were younger, employed, achieved education beyond grade school, and had computer and e-mail access were more likely to own cell telephones. Not owning a cell telephone decreased the likelihood of belonging to the high-social-integration group compared with the low-integration group (odds ratio, .509; 95% confidence interval,.396-.654). Persons with low or medium social integration scores were less likely to own a cell telephone than those who had high social integration scores.
   Conclusion: In this study, most participants owned a cell telephone, although 27% did not compared with 13% nonowners in the general population. Owning a cell telephone increased the likelihood of being more socially integrated compared with non-cell telephone ownership.
C1 [Roach, Mary Joan; Nemunaitis, Gregory] Case Western Reserve Univ, Metrohlth Med Ctr, Cleveland, OH 44109 USA.
   [Roach, Mary Joan; Nemunaitis, Gregory] Case Western Reserve Univ, Cleveland, OH 44106 USA.
   [Roach, Mary Joan] Ctr Hlth Res & Policy, Cleveland, OH USA.
   [Harrington, Amanda] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA.
   [Powell, Heather] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Roach, MJ (reprint author), Case Western Reserve Univ, Metrohlth Med Ctr, 2500 MetroHlth Dr,Rammelkamp R222A, Cleveland, OH 44109 USA.
EM mroach@metrohealth.org
FU National Institute on Disability and Rehabilitation Research
   [H133N060017]
FX Supported by the National Institute on Disability and Rehabilitation
   Research (grant no. H133N060017).
NR 20
TC 4
Z9 4
U1 1
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD MAR
PY 2011
VL 92
IS 3
BP 472
EP 476
DI 10.1016/j.apmr.2010.09.030
PG 5
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 732NF
UT WOS:000288191400020
PM 21353829
ER

PT J
AU Pan, YL
   Hill, SC
   Pinnick, RG
   House, JM
   Flagan, RC
   Chang, RK
AF Pan, Yong-Le
   Hill, Steven C.
   Pinnick, Ronald G.
   House, James M.
   Flagan, Richard C.
   Chang, Richard K.
TI Dual-excitation-wavelength fluorescence spectra and elastic scattering
   for differentiation of single airborne pollen and fungal particles
SO ATMOSPHERIC ENVIRONMENT
LA English
DT Article
DE Real-time classification; Pollen; Fungal; Two-excitation-wavelength;
   Fluorescence spectra; Elastic scattering
ID REAL-TIME MEASUREMENT; BIOLOGICAL PARTICLES; ATMOSPHERIC AEROSOL;
   IMAGE-ANALYSIS; MICROSCOPY; CLASSIFICATION; AUTOFLUORESCENCE;
   BIOAEROSOLS; GRAINS; SPECTROMETER
AB Fluorescence spectra of aerosolized pollen (12 species or subspecies) and fungal (4 species) samples measured using a Dual-excitation-wavelength Particle Fluorescence Spectrometer (DPFS) are reported. The DPFS records two fluorescence spectra and two elastic scattering intensities from single airborne particles as they flow through an optical cell. Each particle is illuminated sequentially, first with a pulse from a 263-nm wavelength laser, followed by a second pulse from a 351-nm laser. The two dispersed fluorescence spectra (from 280 nm-700 nm) and elastic scattering intensities are measured by a single 32-anode photomultiplier tube. Principal component analysis (PCA) of the spectra is used to examine differences in the spectra. Plots of several principal components show that samples of pollens and fungal materials can largely be differentiated. These preliminary results suggest that fluorescence spectra and elastic scattering may be useful for real-time discrimination among a variety of airborne pollens, fungal materials, and other airborne particles. Published by Elsevier Ltd.
C1 [Pan, Yong-Le; Hill, Steven C.; Pinnick, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA.
   [House, James M.; Flagan, Richard C.] CALTECH, Pasadena, CA 91125 USA.
   [Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06511 USA.
RP Pan, YL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
EM yongle.pan@arl.army.mil
FU U.S. Army Research Laboratory
FX This research was supported by the U.S. Army Research Laboratory mission
   funds.
NR 52
TC 38
Z9 39
U1 1
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1352-2310
J9 ATMOS ENVIRON
JI Atmos. Environ.
PD MAR
PY 2011
VL 45
IS 8
BP 1555
EP 1563
DI 10.1016/j.atmosenv.2010.12.042
PG 9
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA 734OW
UT WOS:000288346100008
ER

PT J
AU Hutinec, A
   Rupcic, R
   Ziher, D
   Smith, KS
   Milhous, W
   Ellis, W
   Ohrt, C
   Schonfeld, ZI
AF Hutinec, Antun
   Rupcic, Renata
   Ziher, Dinko
   Smith, Kirsten S.
   Milhous, Wilbur
   Ellis, William
   Ohrt, Colin
   Schoenfeld, Zrinka Ivezic
TI An automated, polymer-assisted strategy for the preparation of urea and
   thiourea derivatives of 15-membered azalides as potential antimalarial
   chemotherapeutics
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Antimalarial; Azalide; Ureas; Thiourea; Automated parallel synthesis;
   Plasmodium falciparum
ID PLASMODIUM-FALCIPARUM MALARIA; DOUBLE-BLIND; QINGHAOSU ARTEMISININ;
   BIOLOGICAL-ACTIVITY; PROTECTING GROUP; DRUG-RESISTANCE; VIVAX MALARIA;
   IN-VITRO; AZITHROMYCIN; TRIAL
AB A series of 15-membered azalide urea and thiourea derivatives has been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive (D6), chloroquine/pyremethamine resistant (W2) and multidrug resistant (TM91C235) strains of Plasmodium falciparum. We have developed an effective automated synthetic strategy for the rapid synthesis of urea/thiourea libraries of a macrolide scaffold. Compounds have been synthesized using a solution phase strategy with overall yields of 50-80%. Most of the synthesized compounds had inhibitory effects. The top 10 compounds were 30-65 times more potent than azithromycin, an azalide with antimalarial activity, against all three strains. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Hutinec, Antun; Rupcic, Renata; Ziher, Dinko; Schoenfeld, Zrinka Ivezic] GlaxoSmithKline Res Ctr Zagreb Ltd, Zagreb 10000, Croatia.
   [Smith, Kirsten S.; Milhous, Wilbur; Ellis, William; Ohrt, Colin] Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC USA.
RP Hutinec, A (reprint author), Galapagos Res Ctr Zagreb Ltd, Prilaz Baruna Filipovica 29, Zagreb 10000, Croatia.
EM antun.hutinec@glpg.com
NR 38
TC 9
Z9 9
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAR 1
PY 2011
VL 19
IS 5
BP 1692
EP 1701
DI 10.1016/j.bmc.2011.01.030
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 726QC
UT WOS:000287740200013
PM 21316974
ER

PT J
AU Cassenti, DN
   Kerick, SE
   McDowell, K
AF Cassenti, Daniel N.
   Kerick, Scott E.
   McDowell, Kaleb
TI Observing and modeling cognitive events through event-related potentials
   and ACT-R
SO COGNITIVE SYSTEMS RESEARCH
LA English
DT Article
DE Cognition; Cognitive modeling; Neuropsychology; Event-related
   potentials; ACT-R; Mental chronometry
ID MENTAL CHRONOMETRY; P300; LATENCY; MEMORY; TIME; MIND
AB The study of cognition is generally thought to rely on techniques for inferring cognitive processes that are unobservable. One approach to cognitive science is to leverage an understanding of structure and function of the nervous system based on observable neurological events to determine mental processing. Event-related potential (ERP) research offers one technique to objectively measure cortical responses that are believed to be associated with perceptual and cognitive processes. Here, two ACT-R (Adaptive Control of Thought - Rational) models of mental processing are adapted based on the results of two ERP experiments. The models provide both a sequence of mental steps required to complete each task and a greater specificity of time course of mental events than traditional ACTR models. We conclude with implications of this research for cognitive theory and ACT-R as well as future work to be conducted. Published by Elsevier B.V.
C1 [Cassenti, Daniel N.] USA, RDRL HRS E, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
   [Kerick, Scott E.] USA, RDRL HRS D, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
   [McDowell, Kaleb] USA, RDRL HRS C, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Cassenti, DN (reprint author), USA, RDRL HRS E, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM dcassenti@arl.army.mil; skerick@arl.army.mil; kmcdowell@arl.army.mil
RI McDowell, Kaleb/A-3410-2009
NR 25
TC 4
Z9 4
U1 2
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-0417
J9 COGN SYST RES
JI Cogn. Syst. Res.
PD MAR
PY 2011
VL 12
IS 1
BP 56
EP 65
DI 10.1016/j.cogsys.2010.01.002
PG 10
WC Computer Science, Artificial Intelligence; Neurosciences; Psychology,
   Experimental
SC Computer Science; Neurosciences & Neurology; Psychology
GA 670OV
UT WOS:000283437600005
ER

PT J
AU Williams, LR
   Aroniadou-Anderjaska, V
   Qashu, F
   Finne, H
   Pidoplichko, V
   Bannon, DI
   Braga, MFM
AF Williams, Larry R.
   Aroniadou-Anderjaska, Vassiliki
   Qashu, Felicia
   Finne, Huckelberry
   Pidoplichko, Volodymyr
   Bannon, Desmond I.
   Braga, Maria F. M.
TI RDX Binds to the GABA(A) Receptor-Convulsant Site and Blocks GABA(A)
   Receptor-Mediated Currents in the Amygdala: A Mechanism for RDX-Induced
   Seizures
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE amygdala; GABA(A) currents; GABA(A) receptors; RDX; seizures
ID BASOLATERAL AMYGDALA; CYCLOTRIMETHYLENETRINITRAMINE RDX; STATUS
   EPILEPTICUS; IN-VITRO; RAT; EPILEPSY; METABOLISM; IONOPHORE; NEURONS;
   BRAIN
AB BACKGROUND: Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a high-energy, trinitrated cyclic compound that has been used worldwide since World War II as an explosive in both military and civilian applications. RDX can be released in the environment by way of waste streams generated during the manufacture, use, and disposal of RDX-containing munitions and can leach into ground-water from unexploded munitions found on training ranges. For > 60 years, it has been known that exposure to high doses of RDX causes generalized seizures, but the mechanism has remained unknown.
   OBJECTIVE: We investigated the mechanism by which RDX induces seizures.
   METHODS AND RESULTS: By screening the affinity of RDX for a number of neurotransmitter receptors, we found that RDX binds exclusively to the picrotoxin convulsant site of the.-aminobutyric acid type A (GABA(A)) ionophore. Whole-cell in vitro recordings in the rat basolateral amygdala (BLA) showed that RDX reduces the frequency and amplitude of spontaneous GABA(A) receptor-mediated inhibitory postsynaptic currents and the amplitude of GABA-evoked post-synaptic currents. In extracellular field recordings from the BLA, RDX induced prolonged, seizure-like neuronal discharges.
   CONCLUSIONS: These results suggest that binding to the GABAA receptor convulsant site is the primary mechanism of seizure induction by RDX and that reduction of GABAergic inhibitory transmission in the amygdala is involved in the generation of RDX-induced seizures. Knowledge of the molecular site and the mechanism of RDX action with respect to seizure induction can guide therapeutic strategies, allow more accurate development of safe thresholds for exposures, and help prevent the development of new explosives or other munitions that could pose similar health risks.
C1 [Aroniadou-Anderjaska, Vassiliki; Qashu, Felicia; Pidoplichko, Volodymyr; Braga, Maria F. M.] USUHS, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
   [Williams, Larry R.; Bannon, Desmond I.] USA, Publ Hlth Command Provis, Aberdeen Proving Ground, MD USA.
   [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] USUHS, Dept Psychiat, Bethesda, MD 20814 USA.
   [Aroniadou-Anderjaska, Vassiliki; Finne, Huckelberry; Braga, Maria F. M.] USUHS, Neurosci Program, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
RP Braga, MFM (reprint author), USUHS, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM mbraga@usuhs.mil
FU CounterACT Program; National Institutes of Health Office of the Director
   through National Institute of Neurological Disorders and Stroke [U01
   NS058162-01]; Defense Brain and Spinal Cord Injury Program [F170TM];
   National Defense Center for Energy and Environment through the
   Concurrent Technologies Corp.; Office of the Assistant Secretary of the
   Army through the National Defense Center for Energy and Environment
   [W74V8H-04-D-0005 Task 0615-A1]
FX This work was supported by the CounterACT Program, National Institutes
   of Health Office of the Director through National Institute of
   Neurological Disorders and Stroke award U01 NS058162-01, Defense Brain
   and Spinal Cord Injury Program award F170TM, and the National Defense
   Center for Energy and Environment through the Concurrent Technologies
   Corp. Additional funding came from the Office of the Assistant Secretary
   of the Army ( Installations and Environment) and conducted under
   contract W74V8H-04-D-0005 Task 0615-A1 through the National Defense
   Center for Energy and Environment, which is operated by the Concurrent
   Technologies Corp.
NR 49
TC 21
Z9 21
U1 0
U2 5
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2011
VL 119
IS 3
BP 357
EP 363
DI 10.1289/ehp.1002588
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 729CU
UT WOS:000287926700025
PM 21362589
ER

PT J
AU Smith, TEM
   Trowbridge, ER
   Pastore, LM
   Smith, SC
   Brennan, MC
   Dooley, Y
   Matthews, CK
   Ozel, B
   Sutkin, G
   Hullfish, KL
AF Smith, Tovia E. Martirosian
   Trowbridge, Elisa R.
   Pastore, Lisa M.
   Smith, Steven C.
   Brennan, Matthew C.
   Dooley, Yashika
   Matthews, Catherine K.
   Oezel, Beguem
   Sutkin, Gary
   Hullfish, Kathie L.
TI Multicenter Urogynecology Study on Education: Medical Student
   Educational Experiences and Knowledge Outcomes During the OBGYN
   Clerkship
SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
LA English
DT Article
DE medical education; female pelvic medicine
AB Objective: The objective of this study was to describe self-assessed student knowledge of female pelvic medicine (FPM) during the OBGYN clerkship.
   Methods: Students at 6 sites scored their knowledge of 12 FPM topics and 4 procedures both before and after their clerkship. Analysis included Wilcoxon tests, Spearman correlation, and univariate and multivariate models.
   Results: A total of 323 students completed paired surveys. Mean knowledge scores (KSs) across FPM topics (1.40 +/- 0.12; 95% confidence interval) and procedures (0.77 +/- 0.08) increased significantly, with larger increases for topics (P < 0.001). Topic and procedure KSs were correlated (r(s) = 0.32, P < 0.0001). Mean KSs were significantly related to number and number of types of learning experiences (r(2) = 0.13 and 0.08, both P < 0.001). Learning through text and inpatient encounters had independent effects on KS change in multivariate analysis (P = 0.01 and 0.007).
   Conclusions: Students reported increased knowledge although less for procedures than for topics. Text and inpatient learning independently increased students' self-assessed change in knowledge.
C1 [Smith, Tovia E. Martirosian; Trowbridge, Elisa R.; Pastore, Lisa M.; Hullfish, Kathie L.] Univ Virginia Hlth Syst, Dept Obstet & Gynaecol, Charlottesville, VA USA.
   [Smith, Steven C.; Hullfish, Kathie L.] Univ Virginia Hlth Syst, Dept Urol, Charlottesville, VA USA.
   [Brennan, Matthew C.] Univ New Mexico, Dept Obstet & Gynecol, Albuquerque, NM 87131 USA.
   [Dooley, Yashika] Brooke Army Med Ctr, Dept Obstet & Gynecol, San Antonio, TX USA.
   [Matthews, Catherine K.] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC USA.
   [Oezel, Beguem] Univ So Calif, Keck Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90033 USA.
   [Sutkin, Gary] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA.
RP Smith, TEM (reprint author), Univ Michigan Hosp, Dept Obstet & Gynecol, Womens Hosp L4000, 1500 E Med Ctr Dr,SPC 5276, Ann Arbor, MI 48109 USA.
EM toviasmith@gmail.com
FU American Urogynecologic Society's Educational Multi-Center Research
   Initiative
FX The authors thank research support from the American Urogynecologic
   Society's Educational Multi-Center Research Initiative. The authors also
   thank the contributions in data entry of Robin Stevens, from the Office
   of Medical Education of the University of Virginia School of Medicine,
   and of Xin Q. Wang of the Division of Biostatistics and Epidemiology,
   Department of Public Health Sciences, University of Virginia.
NR 20
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2151-8378
J9 FEMALE PELVIC MED RE
JI Female Pelvic Med. Reconstr. Surg.
PD MAR-APR
PY 2011
VL 17
IS 2
BP 100
EP 104
DI 10.1097/SPV.0b013e31820e9df3
PG 5
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA V35WN
UT WOS:000209176100010
ER

PT J
AU Duysen, EG
   Parikh, K
   Aleti, V
   Manne, V
   Lockridge, O
   Chilukuri, N
AF Duysen, E. G.
   Parikh, K.
   Aleti, V.
   Manne, V.
   Lockridge, O.
   Chilukuri, N.
TI Adenovirus-mediated human paraoxonase1 gene transfer to provide
   protection against the toxicity of the organophosphorus pesticide
   toxicant diazoxon
SO GENE THERAPY
LA English
DT Article
DE gene delivery; adenovirus; paraoxonase1; organophosphorus pesticides;
   chemical warfare nerve agents
ID HUMAN SERUM PARAOXONASE; RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; NERVE
   AGENT TOXICITY; IN-VIVO; OXIDATIVE STRESS; ENZYME-ACTIVITY; SOMAN;
   ATHEROSCLEROSIS; INTOXICATION; PURIFICATION
AB Human paraoxonase1 (hPON1) is a potential therapeutic against the toxicity of organophosphorus (OP) pesticides and chemical warfare nerve agents. We tested whether PON1 gene transfer using adenovirus provides protection against the toxicity of the OP diazoxon. Using an adenovirus construct containing hPON1 gene, we showed elevated levels of recombinant hPON1 in vitro in 293A cells and in vivo in mice. The recombinant enzyme was secreted by 293A cells into culture medium and into the systemic circulation of mice. Western blotting revealed that the virally expressed hPON1 had the expected molecular weight of 45 kDa. Recombinant hPON1 in mice was in complex with mouse high-density lipoprotein (HDL) and migrated more slowly than endogenous hPON1 in the human HDL complex. Mice injected with adenovirus expressed PON1 at 600-3480 U ml(-1) on day 5 post-treatment, which is 8-50-fold above endogenous. Six mice expressing hPON1 survived 2LD(50) doses of diazoxon. Four of the six mice survived a second dose of diazoxon (for a total of 4LD(50)) administered 24 h later. In contrast, none of the three mice in the control group survived one 2LD(50) dose. These results show that hPON1 in mice functions as a prophylactic and offers significant protection against lethal doses of diazoxon. Gene Therapy (2011) 18, 250-257; doi:10.1038/gt.2010.136; published online 28 October 2010
C1 [Duysen, E. G.; Lockridge, O.] Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE USA.
   [Parikh, K.; Aleti, V.; Manne, V.; Chilukuri, N.] Walter Reed Army Inst Res, Div Biochem, Dept Mol Pharmacol, Silver Spring, MD USA.
RP Chilukuri, N (reprint author), USA, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM nageswararao.chilukuri@US.army.mil
OI Duysen, Ellen/0000-0002-0128-9032
FU Defense Threat Reduction Agency (DTRA), Department of Defense
   [1.D003_09_WR_C]; US Army Medical and Materiel Command
   [W81XWH-07-2-0034]
FX This work was supported by funds from Defense Threat Reduction Agency
   (DTRA), Department of Defense (Project No. 1.D003_09_WR_C to Dr
   Chilukuri) and US Army Medical and Materiel Command W81XWH-07-2-0034 (to
   Dr Oksana Lockridge). We also thank Dr Gregory E Garcia (Division of
   Biochemistry, WRAIR) for valuable suggestions with the manuscript.
NR 41
TC 17
Z9 21
U1 2
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0969-7128
J9 GENE THER
JI Gene Ther.
PD MAR
PY 2011
VL 18
IS 3
BP 250
EP 257
DI 10.1038/gt.2010.136
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity; Medicine, Research & Experimental
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity; Research & Experimental Medicine
GA 732QL
UT WOS:000288203600006
PM 20981111
ER

PT J
AU Waddell, SR
AF Waddell, Steve R.
TI Danger's Hour: The Story of the USS Bunker Hill and the Kamikaze Pilot
   Who Crippled Her
SO HISTORIAN
LA English
DT Book Review
C1 [Waddell, Steve R.] US Mil Acad, West Point, NY 10996 USA.
RP Waddell, SR (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0018-2370
J9 HISTORIAN
JI Historian
PD SPR
PY 2011
VL 73
IS 1
BP 146
EP 147
DI 10.1111/j.1540-6563.2010.00288_25.x
PG 2
WC History
SC History
GA 732TP
UT WOS:000288212900030
ER

PT J
AU Mann, EA
   Jones, JA
   Wolf, SE
   Wade, CE
AF Mann, Elizabeth A.
   Jones, John A.
   Wolf, Steven E.
   Wade, Charles E.
TI Computer Decision Support Software Safely Improves Glycemic Control in
   the Burn Intensive Care Unit: A Randomized Controlled Clinical Study
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID CRITICALLY-ILL PATIENTS; INSULIN THERAPY; GLUCOSE CONTROL;
   BLOOD-GLUCOSE; SEVERE HYPOGLYCEMIA; HYPERGLYCEMIA; MORTALITY; IMPACT;
   ASSOCIATION; GLUCOMETERS
AB The optimal method for glycemic control in the critically burned patient is unknown. The purpose of this randomized controlled study was to determine the safety and efficacy of computer decision support software (CDSS) to control serum glucose concentration in a burn intensive care unit. Eighteen adult burn/trauma patients receiving continuous insulin infusion were initially randomized to receive glucose management by a traditional paper protocol or a computer protocol (CP) for 72 hours and then crossed over to the alternate method for an additional 72 hours. Time in target glucose range (range: 80-110 mg/dl) was higher in the CP group (47 +/- 17% vs 41 +/- 16.6%; P <= 05); time over target range was not significantly reduced in the CP group (49 +/- 17.8% vs 54 +/- 17.1%; P = .08); and no difference was noted in time under target range of 80 mg/dl (CP: 4.5 +/- 2.8%, paper protocol: 4.8 +/- 3.3%; P = .8), less than 60 mg/dl (P = .7), and less than 40 mg/dl (P = 1.0). Severe hypoglycemic events (< 40 mg/dl) did not differ from the CP group compared with historical controls for patients receiving no insulin (P = .6). More glucose measurements were performed in the CP group (P = .0003), and nursing staff compliance with CP recommendations was greater (P < .0001). Glycemic control using CDSS is safe and effective for the critically burned patient. Time in target range improved without increase in hypoglycemic events. CDSS enhanced consistency in practice, providing standardization among nursing staff. (J Burn Care Res 2011; 32: 246-255)
C1 [Mann, Elizabeth A.; Jones, John A.; Wolf, Steven E.; Wade, Charles E.] USA, Burn Ctr, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA.
RP Mann, EA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
OI Wolf, Steven/0000-0003-2972-3440
FU National Institutes of Health [1 R01 GM063120-04]; Technologies for
   Metabolic Monitoring (TMM)/Julia Weaver Fund; Combat Casualty Care
   Division, United States Army Medical Research and Materiel Command
FX Supported by The National Institutes of Health (1 R01 GM063120-04); The
   Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund, A
   Congressionally Directed Program Jointly Managed by the USA MRMC, NIH,
   NASA, and the Juvenile Diabetes Research Foundation; and Combat Casualty
   Care Division, United States Army Medical Research and Materiel Command.
NR 30
TC 10
Z9 10
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2011
VL 32
IS 2
BP 246
EP 255
DI 10.1097/BCR.0b013e31820aaebf
PG 10
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA 722ZO
UT WOS:000287475100016
PM 21240001
ER

PT J
AU Dahagam, CK
   Mora, A
   Wolf, SE
   Wade, CE
AF Dahagam, Chaitanya K.
   Mora, Alejandra
   Wolf, Steven E.
   Wade, Charles E.
TI Diabetes Does Not Influence Selected Clinical Outcomes in Critically Ill
   Burn Patients
SO JOURNAL OF BURN CARE & RESEARCH
LA English
DT Article
ID INTENSIVE-CARE-UNIT; INJURED TRAUMA PATIENTS; ACUTE
   MYOCARDIAL-INFARCTION; EARLY HYPERGLYCEMIC CONTROL; HOSPITAL MORTALITY;
   GLUCOSE CONTROL; ADMISSION HYPERGLYCEMIA; GLYCEMIC CONTROL; INSULIN
   THERAPY; HEMOGLOBIN A1C
AB The purpose of this study was to evaluate glucose control and clinical outcomes in diabetic burn intensive care unit (ICU) patients. The authors reviewed 462 civilian patients admitted to the burn ICU over 4 years. Exclusion criteria were age <18 years, admission because of skin infection, incomplete records, and military patients. Subjects were labeled as diabetic if they had a diagnosis of diabetes documented in their medical records. Otherwise, they were labeled as nondiabetic. Diabetic patients (n = 57) were compared with nondiabetic patients (n = 405). Admission glucose levels were obtained from chemistries. Point-of-care devices provided the remaining glucose values. While in the burn ICU, hyperglycemia for all patients was treated using intensive insulin therapy with a target blood glucose level of 80 to 110 mg/dl. Mann-Whitney U test, chi(2) test, and multivariate regressions were used for statistical analysis (P <= .05). Diabetic patients were older (60 +/- 15 vs 44 +/- 17 years) with higher admission glucose (196 +/- 81 vs 133 +/- 52 mg/dl), mean glucose (147 +/- 37 vs 122 +/- 24 mg/dl), glucose variability (30 +/- 11 vs 22 +/- 11%), and fewer ICU-free days (18 +/- 12 vs 20 +/- 11). After multivariate regression analyses, age, injury severity score, TBSA, admission glucose, and mean glucose significantly affected the number of ventilator-free days, ICU-free days, and hospital-free days. Glucose variability was associated with hospital-free days only. Age, injury severity score, and TBSA significantly influenced mortality, whereas a preexisting diagnosis of diabetes was not associated with any clinical outcomes. Admission blood glucose is higher, and blood glucose is more difficult to control in diabetic burn ICU patients. A preexisting diagnosis of diabetes does not influence clinical outcomes in critically ill burn patients. (J Burn Care Res 2011; 32: 256-262)
C1 [Dahagam, Chaitanya K.; Mora, Alejandra; Wolf, Steven E.; Wade, Charles E.] USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
   [Dahagam, Chaitanya K.; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Burn & Trauma Surg, San Antonio, TX 78229 USA.
RP Dahagam, CK (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA.
OI Wolf, Steven/0000-0003-2972-3440
FU National Institutes of Health [1 R01 GM063120-04]; Technologies for
   Metabolic Monitoring (TMM)/Julia Weaver Fund; Combat Casualty Care
   Division, United States Army Medical Research and Materiel Command
FX Supported by grants from The National Institutes of Health (1 R01
   GM063120-04); The Technologies for Metabolic Monitoring (TMM)/Julia
   Weaver Fund, A Congressionally Directed Program Jointly Managed by the
   USA MRMC, NIH, NASA, and the Juvenile Diabetes Research Foundation; and
   Combat Casualty Care Division, United States Army Medical Research and
   Materiel Command.
NR 54
TC 8
Z9 8
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1559-047X
J9 J BURN CARE RES
JI J. Burn Care Res.
PD MAR-APR
PY 2011
VL 32
IS 2
BP 256
EP 262
DI 10.1097/BCR.0b013e31820aaf68
PG 7
WC Emergency Medicine; Dermatology; Surgery
SC Emergency Medicine; Dermatology; Surgery
GA 722ZO
UT WOS:000287475100017
PM 21228710
ER

PT J
AU Min, JK
   Dunning, A
   Lin, FY
   Achenbach, S
   Al-Mallah, MH
   Berman, DS
   Budoff, MJ
   Cademartiri, F
   Callister, TQ
   Chang, HJ
   Cheng, V
   Chinnaiyan, KM
   Chow, B
   Delago, A
   Hadamitzky, M
   Hausleiter, J
   Karlsberg, RP
   Kaufmann, P
   Maffei, E
   Nasir, K
   Pencina, MJ
   Raff, GL
   Shaw, LJ
   Villines, TC
AF Min, James K.
   Dunning, Allison
   Lin, Fay Y.
   Achenbach, Stephan
   Al-Mallah, Mouaz H.
   Berman, Daniel S.
   Budoff, Matthew J.
   Cademartiri, Filippo
   Callister, Tracy Q.
   Chang, Hyuk-Jae
   Cheng, Victor
   Chinnaiyan, Kavitha M.
   Chow, Benjamin
   Delago, Augustin
   Hadamitzky, Martin
   Hausleiter, Jorg
   Karlsberg, Ronald P.
   Kaufmann, Philipp
   Maffei, Erica
   Nasir, Khurram
   Pencina, Michael J.
   Raff, Gilbert L.
   Shaw, Leslee J.
   Villines, Todd C.
TI Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN
   For Clinical Outcomes: An InteRnational Multicenter) Registry
SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
LA English
DT Article
DE Computed tomography; Atherosclerosis; Prognosis; Coronary disease;
   Nonobstructive
AB BACKGROUND: Coronary computed tomographic angiography (CCTA) of 64-detector rows or greater represents a novel noninvasive anatomic method for evaluation of patients with suspected coronary artery disease (CAD). Early studies suggest a potential for prognostic risk assessment by CCTA findings but were limited by small patient cohorts or single centers. The CONFIRM (COronary CTAngiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry is a large, prospective, multinational dynamic observational study of patients undergoing CCTA. The primary aim of CONFIRM is to determine the prognostic value of CCTA findings for the prediction of future adverse CAD events.
   METHODS: The CONFIRM registry currently represents 27,125 consecutive patients at 12 cluster sites in 6 countries in North America, Europe, and Asia. CONFIRM sites were chosen on the basis of adequate CCTA volume, site CCTA proficiency, and local demographic characteristics and medical facilities to ensure a broad-based sample of patients. Patients comprising the present CONFIRM cohort include those with suspected but without known CAD, with known CAD, or asymptomatic persons undergoing CAD evaluation. A data dictionary comprising a wide array of demographic, clinical, and CCTA findings was developed by the CONFIRM investigators and is uniformly used for all patients. Patients are followed up after CCTA performance to identify adverse CAD events, including death, myocardial infarction, unstable angina, target vessel revascularization, and CAD-related hospitalization.
   CONCLUSIONS: From a number of countries worldwide, the information collected from the CONFIRM registry will add incremental and important insights into CCTA findings that confer prognostic value beyond demographic and clinical characteristics. The results of the CONFIRM registry will provide valuable information about the optimal methods for using CCTA findings. (C) 2011 Society of Cardiovascular Computed Tomography. All rights reserved.
C1 [Min, James K.; Lin, Fay Y.] Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA.
   [Min, James K.] Weill Cornell Med Coll, Dept Radiol, New York, NY 10021 USA.
   [Dunning, Allison] Weill Cornell Med Coll, Dept Publ Hlth, New York, NY 10021 USA.
   [Dunning, Allison] New York Presbyterian Hosp, New York, NY 10021 USA.
   [Achenbach, Stephan] Univ Ehrlangen, Dept Med, Ehrlangen, Germany.
   [Al-Mallah, Mouaz H.] Wayne State Univ, Dept Med, Henry Ford Hosp, Detroit, MI 48202 USA.
   [Berman, Daniel S.; Cheng, Victor] Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA.
   [Budoff, Matthew J.] Harbor UCLA Med Ctr, Dept Med, Los Angeles, CA USA.
   [Cademartiri, Filippo; Maffei, Erica] Univ Hosp Parma, Dept Radiol, Parma, Italy.
   [Callister, Tracy Q.] Tennessee Heart & Vasc Inst, Hendersonville, TN USA.
   [Chang, Hyuk-Jae] Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
   [Chinnaiyan, Kavitha M.; Raff, Gilbert L.] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA.
   [Chow, Benjamin] Univ Ottawa, Dept Med & Radiol, Ottawa, ON K1N 6N5, Canada.
   [Delago, Augustin] Capital Cardiol Associates, Albany, NY USA.
   [Hadamitzky, Martin; Hausleiter, Jorg] Univ Munich, Div Cardiol, Munich, Germany.
   [Karlsberg, Ronald P.] Univ Calif Los Angeles, David Geffen Sch Med, Cardiovasc Res Fdn, Beverly Hills, CA USA.
   [Kaufmann, Philipp] Univ Zurich Hosp, CH-8091 Zurich, Switzerland.
   [Nasir, Khurram] Yale Univ, Sch Med, New Haven, CT USA.
   [Pencina, Michael J.] Harvard Clin Res Inst, Boston, MA USA.
   [Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
   [Villines, Todd C.] Walter Reed Army Med Ctr, Dept Internal Med, Serv Cardiol, Washington, DC 20307 USA.
RP Min, JK (reprint author), Weill Cornell Med Coll, Dept Med, New York, NY 10021 USA.
EM jkm2001@med.cornell.edu
RI Cademartiri, Filippo/H-7336-2015; Maffei, Erica/J-2370-2016; 
OI Cademartiri, Filippo/0000-0002-0579-3279; Maffei,
   Erica/0000-0002-0388-4433; Villines, Todd/0000-0003-2674-3702;
   Al-Mallah, Mouaz/0000-0003-2348-0484
FU Siemens; Bayer Schering Pharma; AHA; BCBS Foundation of Michigan;
   Astellas; GE Healthcare; Bayer Pharma; Blue Cross Blue Shield Blue Care
   MI; Pfizer; AstraZeneca; Siemens Medical Systems; Swiss National Science
   Foundation
FX S.A. has received grant support from Siemens and Bayer Schering Pharma
   and is a consultant for Servier. M.A.-M. has received support from AHA,
   BCBS Foundation of Michigan, and Astellas. M.J.B. has received modest
   compensation from the speakers bureau of GE Healthcare. F.C. has
   received grant support from GE Healthcare. K.C. has received grant
   support from Bayer Pharma, Blue Cross Blue Shield Blue Care MI. B.C. has
   received research and fellowship support from GE Healthcare and research
   support from Pfizer and AstraZeneca and educational support from
   TeraRecon. J.H. has received research support from Siemens Medical
   Systems. P.K. has received institutional research support from GE
   Healthcare and grant support from Swiss National Science Foundation.
   E.M. has received grant support from GE Healthcare. J.K.M. has received
   modest compensation from the speakers bureau and medical advisory board
   and significant research support from GE Healthcare. G.L.R. has received
   grant support from Siemens, Blue Cross Blue Shield Blue Care MI, and
   Bayer Pharma. The other authors report no conflicts of interest.
NR 22
TC 55
Z9 55
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-5925
J9 J CARDIOVASC COMPUT
JI J. Cardiovasc. Comput. Tomogr.
PD MAR-APR
PY 2011
VL 5
IS 2
BP 84
EP 92
DI 10.1016/j.jcct.2011.01.007
PG 9
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA V34CH
UT WOS:000209064000003
PM 21477786
ER

PT J
AU Cheezum, MK
   Hulten, EA
   Taylor, AJ
   Gibbs, BT
   Hinds, SR
   Feuerstein, IM
   Stack, AL
   Villines, TC
AF Cheezum, Michael K.
   Hulten, Edward A.
   Taylor, Allen J.
   Gibbs, Barnett T.
   Hinds, Sidney R.
   Feuerstein, Irwin M.
   Stack, Aaron L.
   Villines, Todd C.
TI Cardiac CT angiography compared with myocardial perfusion stress testing
   on downstream resource utilization
SO JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
LA English
DT Article
DE Cardiac computed tomography; Myocardial perfusion stress; Single photon
   emission computed tomography; Coronary artery disease; Resource
   utilization
AB BACKGROUND: Nuclear myocardial perfusion stress (MPS) testing and cardiac computed tomographic angiography (CCTA) are commonly used noninvasive tests. Limited studies exist comparing their clinical and cost outcomes.
   OBJECTIVES: We compared the clinical and cost outcomes of MPS with CCTA in a symptomatic cohort.
   METHODS: We retrospectively identified 241 symptomatic patients without known coronary artery disease (CAD) who underwent MPS between May 2006 and April 2008. A comparison group of 252 age-and sex-matched symptomatic patients without known CAD underwent 64-slice CCTA during the same period. The primary outcome was the per-patient rate of posttest clinical evaluations and cardiac testing for the presenting symptom. Total direct costs were also compared.
   RESULTS: The group consisted of 44% women of mean age 53 +/- 10 years. There were no differences in risk factors or pretest probability of obstructive CAD (83% intermediate risk) between groups. During mean follow-up of 30 +/- 7 months, we found no difference between CCTA and MPS in per-patient rates of any posttest evaluation or testing, 24.6% versus 27.7% (P = 0.44), respectively. CCTA patients had lower utilization of invasive angiography (3.3% vs 8.1%; P = 0.02) and a nonsignificant trend toward reduced downstream cardiac testing (11.5% vs 17.0%; P = 0.08). Including the evaluation of significant incidental findings (7.1% in CCTA), mean direct costs were significantly lower using CCTA ($808; 95% CI, $611-$1005) compared with MPS ($1315; 95% CI, $1105-$ 1525; P <0.001).
   CONCLUSIONS: Low-intermediate risk patients without known CAD who underwent CCTA, compared with MPS, had similar rates of posttest evaluations, fewer invasive catheterizations, and lower overall evaluation costs. Published by Elsevier Inc on behalf of Society of Cardiovascular Computed Tomography.
C1 [Cheezum, Michael K.; Hulten, Edward A.; Gibbs, Barnett T.; Villines, Todd C.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA.
   [Taylor, Allen J.] Washington Hosp Ctr, Serv Cardiol, Washington, DC 20010 USA.
   [Hinds, Sidney R.; Stack, Aaron L.] Walter Reed Army Med Ctr, Dept Nucl Med, Washington, DC 20307 USA.
   [Feuerstein, Irwin M.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA.
RP Villines, TC (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Bldg 2,Room 4A-34A,6900 Georgia Ave NW, Washington, DC 20307 USA.
EM todd.villines@amedd.army.mil
OI Villines, Todd/0000-0003-2674-3702; Hulten, Edward/0000-0001-9281-0032
NR 25
TC 17
Z9 17
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-5925
J9 J CARDIOVASC COMPUT
JI J. Cardiovasc. Comput. Tomogr.
PD MAR-APR
PY 2011
VL 5
IS 2
BP 101
EP 109
DI 10.1016/j.jcct.2010.11.005
PG 9
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA V34CH
UT WOS:000209064000005
PM 21256102
ER

PT J
AU Bauer, AJ
AF Bauer, Andrew J.
TI Approach to the Pediatric Patient with Graves' Disease: When Is
   Definitive Therapy Warranted?
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID DIFFERENTIATED THYROID-CANCER; ANTITHYROID DRUG-THERAPY;
   PARATHYROID-HORMONE; JUVENILE THYROTOXICOSIS; AUTOIMMUNE
   HYPERTHYROIDISM; CHILDHOOD THYROTOXICOSIS; PREPUBERTAL CHILDREN; MEDICAL
   THERAPY; ADOLESCENTS; MANAGEMENT
AB Pediatric Graves' disease accounts for 10-15% of thyroid disorders in patients less than 18 yr of age. The onset of symptoms may be insidious and subsequently associated with a delay in diagnosis. Decreased concentration and poor school performance are frequent complaints and can be quite frustrating for the patient and family. Severe ophthalmopathy is uncommon. The diagnosis is established by the findings of an increased heart rate and goiter in the setting of a suppressed TSH and elevated T-3 and/or T-4. The majority of pediatric patients are initially placed on antithyroid medications and maintained on these medications for prolonged periods of time in hopes of achieving remission. Unfortunately, for many children and adolescents remission is unattainable, ultimately occurring in only 15-30% of patients. Several recent studies have suggested that the age of the patient, the degree of thyrotoxicosis at diagnosis, the initial response to therapy, and the level of TSH receptor antibodies serve as reasonable predictors of remission and relapse. However, a consensus on the utility of these markers has not been reached. The present clinical case describes an adolescent with Graves' disease and highlights the negative impact that prolonged medical therapy can have on quality of life and school performance; it reviews pertinent data on the diagnosis, comorbidities, and treatment options; and it identifies gaps in knowledge for when definitive therapy should be pursued. The case serves as a reminder that earlier discussion and decision for definitive therapy should be more commonplace in caring for our pediatric patients with Graves' disease. (J Clin Endocrinol Metab 96: 580-588, 2011)
C1 [Bauer, Andrew J.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA.
   [Bauer, Andrew J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Bauer, Andrew J.] Childrens Hosp Philadelphia, Thyroid Ctr, Div Endocrinol, Philadelphia, PA 19104 USA.
RP Bauer, AJ (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
EM abauer@usuhs.mil
NR 65
TC 13
Z9 14
U1 1
U2 2
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2011
VL 96
IS 3
BP 580
EP 588
DI 10.1210/jc.2010-0898
PG 9
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 730GA
UT WOS:000288020600021
PM 21378220
ER

PT J
AU Chan, JK
   Sherman, AE
   Kapp, DS
   Zhang, RX
   Osann, KE
   Maxwell, L
   Chen, LM
   Deshmukh, H
AF Chan, John K.
   Sherman, Alexander E.
   Kapp, Daniel S.
   Zhang, Ruxi
   Osann, Kathryn E.
   Maxwell, Larry
   Chen, Lee-May
   Deshmukh, Harshal
TI Influence of Gynecologic Oncologists on the Survival of Patients With
   Endometrial Cancer
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID EPITHELIAL OVARIAN-CANCER; UTERINE-CANCER; CARE; CARCINOMA; OUTCOMES;
   TRIAL; LYMPHADENECTOMY; PATHOLOGISTS; RADIOTHERAPY; DIAGNOSIS
AB Purpose Despite a lack of evidence for survival benefit, the American College of Obstetrics and Gynecology has recommendations for referral to gynecologic oncologists for the treatment of endometrial cancer. Therefore, we propose to determine the influence of gynecologic oncologists on the treatment and survival of patients with endometrial cancer.
   Patients and Methods Data were obtained from Medicare and Surveillance, Epidemiology, and End Results (SEER) databases from 1988 to 2005. Kaplan-Meier and Cox proportional hazard methods were used for analyses.
   Results Of 18,338 women, 21.4% received care from gynecologic oncologists (group A) while 78.6% were treated by others (group B). Women in group A were older (age > 71 years: 49.6% v 44%; P < .001), had more lymph nodes (> 16) removed (22% v 17%; P < .001), presented with more advanced (stages III to IV) cancers (21.9% v 14.6%; P < .001), had higher-grade tumors (P < .001), and were more likely to receive chemotherapy for advanced disease (22.6% v 12.4%; P < .001). In those with stages II to IV disease, the 5-year disease-specific survival (DSS) of group A was 79% versus 73% in group B (P = .001). Moreover, in advanced-stage (III to IV) disease, group A had 5-year DSS of 72% versus 64% in group B (P < .001). However, no association with DSS was identified in stage I cancers. On multivariable analysis, younger age, early stage, lower grade, and treatment by gynecologic oncologists were independent prognostic factors for improved survival.
   Conclusion Patients with endometrial cancer treated by gynecologic oncologists were more likely to undergo staging surgery and receive adjuvant chemotherapy for advanced disease. Care provided by gynecologic oncologists improved the survival of those with high-risk cancers. J Clin Oncol 29:832-838. (C) 2011 by American Society of Clinical Oncology
C1 [Chan, John K.] Univ Calif San Francisco, Sch Med, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA.
   Univ Calif Irvine, Irvine Med Ctr, Chao Family Comprehens Canc Ctr, Orange, CA 92668 USA.
   Stanford Univ, Sch Med, Stanford Canc Ctr, Stanford, CA USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Chan, JK (reprint author), Univ Calif San Francisco, Sch Med, Helen Diller Family Comprehens Canc Ctr, 1600 Divisadero St,Box 1702, San Francisco, CA 94143 USA.
EM chanjohn@obgyn.ucsf.edu
FU Stanford Cancer Center; John A. Kerner Research Funding in Gynecologic
   Oncology
FX Supported by a Stanford Cancer Center Developmental Research Award
   (J.K.C.) and John A. Kerner Research Funding in Gynecologic Oncology.
NR 26
TC 37
Z9 38
U1 0
U2 2
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAR 1
PY 2011
VL 29
IS 7
BP 832
EP 838
DI 10.1200/JCO.2010.31.2124
PG 7
WC Oncology
SC Oncology
GA 726NO
UT WOS:000287729900023
PM 21263082
ER

PT J
AU Summers, RM
   Baecher, N
   Yao, JH
   Liu, JM
   Pickhardt, PJ
   Choi, JR
   Hill, S
AF Summers, Ronald M.
   Baecher, Nicolai
   Yao, Jianhua
   Liu, Jiamin
   Pickhardt, Perry J.
   Choi, J. Richard
   Hill, Suvimol
TI Feasibility of Simultaneous Computed Tomographic Colonography and Fully
   Automated Bone Mineral Densitometry in a Single Examination
SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
LA English
DT Article
DE radiology; population studies; bone densitometry; bone QCT; osteoporosis
ID OLDER US ADULTS; CT COLONOGRAPHY; COLORECTAL ADENOMAS; AIDED DETECTION;
   CALCIUM SUPPLEMENTATION; QUANTITATIVE CT; 2ND READER; NHANES-III;
   DENSITY; OSTEOPOROSIS
AB Purpose: To show the feasibility of calculating the bone mineral density (BMD) from computed tomographic colonography (CTC) scans using fully automated software.
   Materials and Methods: Automated BMD measurement software was developed that measures the BMD of the first and second lumbar vertebrae on computed tomography and calculates the mean of the 2 values to provide a per patient BMD estimate. The software was validated in a reference population of 17 consecutive women who underwent quantitative computed tomography and in a population of 475 women from a consecutive series of asymptomatic patients enrolled in a CTC screening trial conducted at 3 medical centers.
   Results: The mean (SD) BMD was 133.6 (34.6) mg/mL (95% confidence interval, 130.5-136.7; n = 475). In women aged 42 to 60 years (n = 316) and 61 to 79 years (n = 159), the mean (SD) BMDs were 143.1 (33.5) and 114.7 (28.3) mg/mL, respectively (P < 0.0001). Fully automated BMD measurements were reproducible for a given patient with 95% limits of agreement of -9.79 to 8.46 mg/mL for the mean difference between paired assessments on supine and prone CTC.
   Conclusions: Osteoporosis screening can be performed simultaneously with screening for colorectal polyps.
C1 [Summers, Ronald M.; Baecher, Nicolai; Yao, Jianhua; Liu, Jiamin; Hill, Suvimol] NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bethesda, MD 20892 USA.
   [Pickhardt, Perry J.] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA.
   [Choi, J. Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Summers, RM (reprint author), NIH, Imaging Biomarkers & Comp Aided Diag Lab, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10,Room 1C224D MSC 1182, Bethesda, MD 20892 USA.
EM rms@nih.gov
FU iCAD; E-Z-EM; National Institutes of Health Clinical Center
FX This article was supported in part by the Intramural Research Program of
   the National Institutes of Health Clinical Center.; Authors Summers and
   Yao have pending and/or awarded patents for the subject matter described
   in the article and receive royalty income for a patent license from
   iCAD. Author Summers is a Johnson & Johnson stockholder. His laboratory
   is supported in part by a cooperative research and development agreement
   with iCAD. Viatronix supplied the V3D Colon software to National
   Institutes of Health free of charge. Author Pickhardt is on the medical
   advisory boards of Viatronix, Inc and Medicsight, Inc, a consultant to
   Philips, and cofounder of VirtuoCTC. Author Choi is on the medical
   advisory boards of Viatronix, Inc and QI and has received research
   support from E-Z-EM. All other authors have no conflicts of interest.
NR 36
TC 26
Z9 26
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0363-8715
EI 1532-3145
J9 J COMPUT ASSIST TOMO
JI J. Comput. Assist. Tomogr.
PD MAR-APR
PY 2011
VL 35
IS 2
BP 212
EP 216
DI 10.1097/RCT.0b013e3182032537
PG 5
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 736MM
UT WOS:000288498800009
PM 21412092
ER

PT J
AU Withrow, RA
   Shenenberger, D
   Kalish, VB
   Krivda, S
AF Withrow, Ryan A.
   Shenenberger, Donald
   Kalish, Virginia B.
   Krivda, Stephen
TI Cellulitis unresponsive to antibiotics
SO JOURNAL OF FAMILY PRACTICE
LA English
DT Editorial Material
ID FEBRILE NEUTROPHILIC DERMATOSIS; SWEETS-SYNDROME
C1 [Withrow, Ryan A.] Womack Family Med Residency Program, Ft Bragg, NC USA.
   [Shenenberger, Donald] Navy Med E, Portsmouth, VA USA.
   [Krivda, Stephen] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   [Kalish, Virginia B.] Dewitt Army Community Hosp Family Med Residency, Natl Capital Consortium, Ft Belvoir, VA USA.
RP Withrow, RA (reprint author), Family Med Residency Clin, 4-2807 Reilly Rd, Ft Bragg, NC 28314 USA.
EM ryan.withrow@us.army.mil
NR 6
TC 1
Z9 1
U1 0
U2 0
PU DOWDEN HEALTH MEDIA
PI MONTVALE
PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA
SN 0094-3509
J9 J FAM PRACTICE
JI J. Fam. Pract.
PD MAR
PY 2011
VL 60
IS 3
BP 149
EP 151
PG 3
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 930IH
UT WOS:000303131700012
PM 21369557
ER

PT J
AU Herbert, JM
AF Herbert, Joseph M.
TI From Santa Elena to St. Augustine: Indigenous Ceramic Variability (AD
   1400-1700)
SO JOURNAL OF FIELD ARCHAEOLOGY
LA English
DT Book Review
C1 [Herbert, Joseph M.] Colorado State Univ, Ctr Environm Management Mil Lands, Cultural Resources Management Program, IMSE BRG DPW, Ft Bragg, NC 28310 USA.
RP Herbert, JM (reprint author), Colorado State Univ, Ctr Environm Management Mil Lands, Cultural Resources Management Program, IMSE BRG DPW, 2175 Reilly Rd, Ft Bragg, NC 28310 USA.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0093-4690
EI 2042-4582
J9 J FIELD ARCHAEOL
JI J. Field Archaeol.
PD MAR
PY 2011
VL 36
IS 1
BP 66
EP 70
PG 5
WC Archaeology
SC Archaeology
GA 745HH
UT WOS:000289156000010
ER

PT J
AU Nderitu, L
   Lee, JS
   Omolo, J
   Omulo, S
   O'Guinn, ML
   Hightower, A
   Mosha, F
   Mohamed, M
   Munyua, P
   Nganga, Z
   Hiett, K
   Seal, B
   Feikin, DR
   Breiman, RF
   Njenga, MK
AF Nderitu, Leonard
   Lee, John S.
   Omolo, Jared
   Omulo, Sylvia
   O'Guinn, Monica L.
   Hightower, Allen
   Mosha, Fausta
   Mohamed, Mohamed
   Munyua, Peninah
   Nganga, Zipporah
   Hiett, Kelli
   Seal, Bruce
   Feikin, Daniel R.
   Breiman, Robert F.
   Njenga, M. Kariuki
TI Sequential Rift Valley Fever Outbreaks in Eastern Africa Caused by
   Multiple Lineages of the Virus
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID RECENT COMMON ANCESTRY; SAUDI-ARABIA; KENYA; LIVESTOCK; MAURITANIA;
   ALIGNMENT; HUMANS
AB Methods. Following confirmation of the RVF epidemic in Kenya on 19 December 2006 and in Tanzania on 2 February 2007, teams were sent to the field for case finding. Human, livestock, and mosquito specimens were collected and viruses isolated. The World Health Organization response team in Kenya worked with the WHO's polio surveillance team inside Somalia to collect information and specimens from Somalia.
   Results. Seven geographical foci that reported hundreds of livestock and > 25 cases in humans between December 2006 and June 2007 were identified. The onset of RVF cases in each epidemic focus was preceded by heavy rainfall and flooding for at least 10 days. Full-length genome analysis of 16 RVF virus isolates recovered from humans, livestock, and mosquitoes in 5 of the 7 outbreak foci revealed 3 distinct lineages of the viruses within and across outbreak foci.
   Conclusion. The findings indicate that the sequential RVF epidemics in the region were caused by multiple lineages of the RVF virus, sometimes independently activated or introduced in distinct outbreak foci.
C1 [Nderitu, Leonard; Omulo, Sylvia; Hightower, Allen; Munyua, Peninah; Feikin, Daniel R.; Breiman, Robert F.; Njenga, M. Kariuki] US Ctr Dis Control & Prevent Kenya, Global Dis Detect Div, Nairobi, Kenya.
   [Lee, John S.; O'Guinn, Monica L.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
   [Omolo, Jared] Kenya Minist Publ Hlth & Sanitat, Nairobi, Kenya.
   [Mosha, Fausta; Mohamed, Mohamed] Tanzania Minist Hlth & Social Work, Dar Es Salaam, Tanzania.
   [Nganga, Zipporah] Jomo Kenyatta Univ Agr & Technol, Nairobi, Kenya.
   [Hiett, Kelli; Seal, Bruce] ARS, USDA, Athens, GA USA.
RP Njenga, MK (reprint author), Ctr Dis Control & Prevent Kenya, Global Dis Detect Program, Unit 8900,Box 6610, Dpo, AE 09831 USA.
EM knjenga@ke.cdc.gov
FU US government through the Centers for Disease Control and Prevention; US
   Army Medical Research Institute of Infectious Diseases
FX For this work was provided by the US government through the Centers for
   Disease Control and Prevention and the US Army Medical Research
   Institute of Infectious Diseases.
NR 28
TC 22
Z9 23
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD MAR 1
PY 2011
VL 203
IS 5
BP 655
EP 665
DI 10.1093/infdis/jiq004
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 717FD
UT WOS:000287028000012
PM 21282193
ER

PT J
AU Awasthi, S
   Brown, K
   King, C
   Awasthi, V
   Bondugula, R
AF Awasthi, Shanjana
   Brown, Kevin
   King, Catherine
   Awasthi, Vibhudutta
   Bondugula, Rajkumar
TI A Toll-Like Receptor-4-Interacting Surfactant Protein-A-Derived Peptide
   Suppresses Tumor Necrosis Factor-alpha Release from Mouse JAWS II
   Dendritic Cells
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID PULMONARY SURFACTANT; SIGNALING PATHWAYS; BINDING-PROTEIN; LUNG;
   EXPRESSION; RECEPTOR-4; TLR4; LIPOPOLYSACCHARIDE; INFECTION; DOCKING
AB Surfactant protein-A (SP-A) and Toll-like receptor-4 (TLR4) proteins are recognized as pathogen-recognition receptors. An exaggerated activation of TLR4 induces inflammatory response, whereas SP-A protein down-regulates inflammation. We hypothesized that SP-A-TLR4 interaction may lead to inhibition of inflammation. In this study, we investigated interaction between native baboon lung SP-A and baboon and human TLR4-MD2 proteins by coimmunoprecipitation/immunoblotting and microwell-based methods. The interaction between SP-A and TLR4-MD2 proteins was then analyzed using a bioinformatics approach. In the in silico model of SP-A-TLR4-MD2 complex, we identified potential binding regions and amino acids at the interface of SP-A-TLR4. Using this information, we synthesized a library of human SP-A-derived peptides that contained interacting amino acids. Next, we tested whether the TLR4-interacting SP-A peptides would suppress inflammatory cytokines. The peptides were screened for any changes in the tumor necrosis factor-alpha (TNF-alpha) response against lipopolysaccharide (LPS) stimuli in the mouse JAWS II dendritic cell line. Different approaches used in this study suggested binding between SP-A and TLR4-MD2 proteins. In cells pretreated with peptides, three of seven peptides increased TNF-alpha production against LPS. However, two of these peptides (SPA4: GDFRYSDGTPVNYTNWYRGE and SPA5: YVGLTEGPSPGDFRYSDFTP) decreased the TNF-alpha production in LPS-challenged JAWS II dendritic cells; SPA4 peptide showed more pronounced inhibitory effect than SPA5 peptide. In conclusion, we identify a human SP-A-derived peptide (SPA4 peptide) that interacts with TLR4-MD2 protein and inhibits the LPS-stimulated release of TNF-alpha in JAWS II dendritic cells.
C1 [Awasthi, Shanjana; Brown, Kevin; King, Catherine; Awasthi, Vibhudutta] Univ Oklahoma, Dept Pharmaceut Sci, Hlth Sci Ctr, Oklahoma City, OK 73117 USA.
   [Bondugula, Rajkumar] USA, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD USA.
RP Awasthi, S (reprint author), Univ Oklahoma, Dept Pharmaceut Sci, Hlth Sci Ctr, 1110 N Stonewall Ave, Oklahoma City, OK 73117 USA.
EM shanjana-awasthi@ouhsc.edu
RI Awasthi, Shanjana/B-4042-2012
FU National Institutes of Health National Center for Research Resources
   [P40-RR012317]; Presbyterian Health Foundation [PHF1539]; University of
   Oklahoma Health Science Center, Oklahoma City [PSXA1]
FX This work was supported by the National Institutes of Health National
   Center for Research Resources [Grant P40-RR012317]; the Presbyterian
   Health Foundation [Grant PHF1539]; and the College of Pharmacy Seed
   Grant Program, University of Oklahoma Health Science Center, Oklahoma
   City [Grant PSXA1].
NR 40
TC 12
Z9 12
U1 1
U2 4
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD MAR
PY 2011
VL 336
IS 3
BP 672
EP 681
DI 10.1124/jpet.110.173765
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 723AI
UT WOS:000287477200010
PM 21159752
ER

PT J
AU Zhang, SS
   Read, J
AF Zhang, Sheng S.
   Read, Jeffrey
TI Partially fluorinated solvent as a co-solvent for the non-aqueous
   electrolyte of Li/air battery
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Fluorinated solvent; Tris(2,2,2-trifluoroethyl) phosphite; Non-aqueous
   electrolyte; Ionic conductivity; Viscosity; Li/air battery
ID LI-AIR BATTERIES; ORGANIC ELECTROLYTE; LITHIUM/OXYGEN BATTERY;
   LITHIUM/AIR BATTERIES; ENERGY DENSITY; OXYGEN; DISCHARGE; MODEL
AB In this work we study methyl nonafluorobutyl ether (MFE) and tris(2,2,2-trifluoroethyl) phosphite (TTFP), respectively, as a co-solvent for the non-aqueous electrolyte of Li-air battery. Results show that in certain solvent ratios, both solvents are able to increase the specific capacity of carbon in Li/O(2) and Li/air cells. More interestingly, the improvement in discharge performance of the Li/air cells increases with discharge current density. These results cannot be explained by the ionic conductivity and viscosity data of the electrolytes since the participation of fluorinated co-solvents hardly changes viscosity of the solvent blends while reversely reduces ionic conductivity of the electrolyte. In particular, we find that a 30 wt.% (vs. solvent) addition of TTFP into a 0.2 m (molality) LiSO(3)CF(3) PC electrolyte can significantly improve the discharge performance of Li/air cells, and that the resultant electrolyte is able to support long-term operation of Li/air cells in dry ambient environments due to its low volatility. We believe that the observed performance improvement is associated with the increased dissolution kinetics and solubility of oxygen in fluorinated solvent containing electrolyte. Published by Elsevier B.V.
C1 [Zhang, Sheng S.; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
EM szhang@arl.army.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 31
TC 41
Z9 44
U1 2
U2 61
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD MAR 1
PY 2011
VL 196
IS 5
BP 2867
EP 2870
DI 10.1016/j.jpowsour.2010.11.021
PG 4
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
   Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 712ZP
UT WOS:000286705100060
ER

PT J
AU Laver, R
   Miller, SK
AF Laver, Richard
   Miller, Sheila K.
TI Left division in the free left distributive algebra on one generator
SO JOURNAL OF PURE AND APPLIED ALGEBRA
LA English
DT Article
ID ELEMENTARY EMBEDDINGS; BRAID-GROUPS
AB Let A be the free algebra on one generator satisfying the left distributive law a(bc) = (ab)(ac). Using a division algorithm for elements of an extension P of A, we prove some facts about left division in A, one consequence of which is a conjecture of J. Moody: If a, b, c, d is an element of A, ab = cd, a and b have no common left divisors, and c and d have no common left divisors, then a = c and b = d. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Miller, Sheila K.] US Mil Acad, Dept Math Sci, MADN MATH, West Point, NY 10996 USA.
   [Laver, Richard] Univ Colorado, Dept Math, Boulder, CO 80309 USA.
RP Miller, SK (reprint author), US Mil Acad, Dept Math Sci, MADN MATH, 646 Swift Rd, West Point, NY 10996 USA.
EM laver@euclid.colorado.edu; sheila.miller@colorado.edu
NR 19
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-4049
J9 J PURE APPL ALGEBRA
JI J. Pure Appl. Algebr.
PD MAR
PY 2011
VL 215
IS 3
BP 276
EP 282
DI 10.1016/j.jpaa.2010.04.019
PG 7
WC Mathematics, Applied; Mathematics
SC Mathematics
GA 687BO
UT WOS:000284749000008
ER

PT J
AU Emery, H
AF Emery, Homer
TI TEJANOS IN GRAY: Civil War Letters of Captains Joseph Rafael de la Garza
   and Manuel Yturri
SO JOURNAL OF THE WEST
LA English
DT Book Review
C1 [Emery, Homer] USA, LTC, San Antonio, TX USA.
RP Emery, H (reprint author), USA, LTC, San Antonio, TX USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ABC-CLIO
PI SANTA BARBARA
PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA
SN 0022-5169
J9 J WEST
JI J. West
PD SPR
PY 2011
VL 50
IS 2
BP 86
EP 86
PG 1
WC History
SC History
GA 973WX
UT WOS:000306392100010
ER

PT J
AU Emery, HC
AF Emery, Homer C.
TI GOODBYE WIFES AND DAUGHTERS
SO JOURNAL OF THE WEST
LA English
DT Book Review
C1 [Emery, Homer C.] USA, LTC, San Antonio, TX USA.
RP Emery, HC (reprint author), USA, LTC, San Antonio, TX USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ABC-CLIO
PI SANTA BARBARA
PA 130 CREMONA DR, SANTA BARBARA, CA 93117 USA
SN 0022-5169
J9 J WEST
JI J. West
PD SPR
PY 2011
VL 50
IS 2
BP 87
EP 87
PG 1
WC History
SC History
GA 973WX
UT WOS:000306392100014
ER

PT J
AU Pappas, D
AF Pappas, Daphne
TI Status and potential of atmospheric plasma processing of materials
SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A
LA English
DT Review
ID DIELECTRIC-BARRIER-DISCHARGE; FLUOROCARBON THIN-FILMS; ATOMIC-EMISSION
   SOURCE; SILICON DIOXIDE FILMS; WORKING GAS SYSTEMS; OPEN-AIR DEPOSITION;
   PRESSURE PE-CVD; GLOW-DISCHARGE; SURFACE MODIFICATION; SILENT DISCHARGE
AB This paper is a review of the current status and potential of atmospheric plasma technology for materials processing. The main focus is the recent developments in the area of dielectric barrier discharges with emphasis in the functionalization of polymers, deposition of organic and inorganic coatings, and plasma processing of biomaterials. A brief overview of both the equipment being used and the physicochemical reactions occurring in the gas phase is also presented. Atmospheric plasma technology offers major industrial, economic, and environmental advantages over other conventional processing methods. At the same time there is also tremendous potential for future research and applications involving both the industrial and academic world. (C) 2011 American Vacuum Society. [DOI: 10.1116/1.3559547]
C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Pappas, D (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM daphne.pappas@us.army.mil
OI Pappas, Daphne/0000-0002-5746-8873
NR 164
TC 68
Z9 69
U1 8
U2 74
PU A V S AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0734-2101
EI 1520-8559
J9 J VAC SCI TECHNOL A
JI J. Vac. Sci. Technol. A
PD MAR-APR
PY 2011
VL 29
IS 2
AR 020801
DI 10.1116/1.3559547
PG 17
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA 730IW
UT WOS:000288028000001
ER

PT J
AU Wasserberg, G
   Rowton, ED
AF Wasserberg, Gideon
   Rowton, Edgar D.
TI Sub-additive effect of conspecific eggs and frass on oviposition rate of
   Lutzomyia longipalpis and Phlebotomus papatasi
SO JOURNAL OF VECTOR ECOLOGY
LA English
DT Article
DE Sand fly; oviposition behavior; attractants; stimulants; leishmaniasis;
   control
ID CHEMICAL ECOLOGY; LETHAL OVITRAP; PSYCHODIDAE; DIPTERA; PHEROMONE;
   SEMIOCHEMICALS; IDENTIFICATION; ATTRACTANTS; MOSQUITOS; SANDFLIES
AB Oviposition behavior is a fairly neglected aspect in our understanding of the biology of sand flies. In this study, we used a comparative approach using both new- and old-world species (Lutzomyia longipalpis and Phlebotomus papatasi) in choice and no-choice oviposition chambers to evaluate the effect of old sand fly colony remains (frass), conspecific eggs, and their combination on oviposition rates of these sand flies. We also tested the effect of egg washing with de-ionized water on oviposition rates. In both choice and no-choice experiments, sand fly species laid more eggs on a substrate containing frass. The effect of eggs alone was not significant but showed a positive trend. Furthermore, for both sand fly species, the effect of the combined treatment was sub-additive suggesting a potential inhibitory effect of one factor on the other. Egg washing did not have a significant effect. The choice and no-choice experimental designs did not differ in their outcomes suggesting the choice-design could serve as an effective high throughput method for screening oviposition attractants/stimulants.
C1 [Wasserberg, Gideon; Rowton, Edgar D.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
RP Wasserberg, G (reprint author), Univ N Carolina, Dept Biol, 235 Eberhart Bldg, Greensboro, NC 27402 USA.
RI Rowton, Edgar/A-1975-2011
OI Rowton, Edgar/0000-0002-1979-1485
FU MIDRP, U.S. Department of Defense
FX This research was funded by a grant through the MIDRP, U.S. Department
   of Defense. Studies were conducted while G. Wasserberg held a NRC
   research Associateship at the Walter Reed Army Institute of Research.
   Special thanks to Kushagra Shamra who assisted in conducting many of the
   bioassays, and to Dr. Coby Schal for helpful discussion and comments.
   The opinions or assertions contained herein are the private views of the
   author, and are not to be construed as official, or as reflecting true
   views of the Department of the Army or the Department of Defense.
   Research was conducted in compliance with the Animal Welfare Act and
   other federal statutes and regulations relating to animals and
   experiments involving animals and adheres to principles stated in the
   Guide for the Care and Use of Laboratory Animals, MRC Publication, 1996
   edition.
NR 27
TC 5
Z9 6
U1 0
U2 8
PU SOC VECTOR ECOLOGY
PI CORONA
PA 1966 COMPTON AVE, CORONA, CA 92881 USA
SN 1081-1710
J9 J VECTOR ECOL
JI J. Vector Ecol.
PD MAR
PY 2011
VL 36
SU 1
SI SI
BP S138
EP S143
DI 10.1111/j.1948-7134.2011.00123.x
PG 6
WC Entomology
SC Entomology
GA 729CZ
UT WOS:000287927300018
PM 21366766
ER

PT J
AU Morris, CJ
   Isaacson, B
   Grapes, MD
   Dubey, M
AF Morris, Christopher J.
   Isaacson, Brian
   Grapes, Michael D.
   Dubey, Madan
TI Self-Assembly of Microscale Parts through Magnetic and Capillary
   Interactions
SO MICROMACHINES
LA English
DT Article
DE self-assembly; solder; magnetic forces
AB Self-assembly is a promising technique to overcome fundamental limitations with integrating, packaging, and general handling of individual electronic-related components with characteristic lengths significantly smaller than 1 mm. Here we describe the use of magnetic and capillary forces to self-assemble 280 mu m sized silicon building blocks into interconnected structures which approach a three-dimensional crystalline configuration. Integrated permanent magnet microstructures provided magnetic forces, while a low-melting-point solder alloy provided capillary forces. A finite element model of forces between the magnetic features demonstrated the utility of magnetic forces at this size scale. Despite a slight departure from designed dimensions in the actual fabricated parts, the combination of magnetic and capillary forces improved the assembly yield to 8%, over approximately 0.1% achieved previously with capillary forces alone.
C1 [Morris, Christopher J.; Isaacson, Brian; Grapes, Michael D.; Dubey, Madan] US Army, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
   [Grapes, Michael D.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
RP Morris, CJ (reprint author), US Army, Sensors & Electron Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM christopher.morris17@arl.army.mil; brian.isaacson@us.army.mil;
   mike.grapes@gmail.com; madan.dubey@us.army.mil
NR 42
TC 6
Z9 6
U1 1
U2 11
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-666X
J9 MICROMACHINES-BASEL
JI Micromachines
PD MAR
PY 2011
VL 2
IS 1
BP 69
EP 81
DI 10.3390/mi2010069
PG 13
WC Nanoscience & Nanotechnology; Instruments & Instrumentation
SC Science & Technology - Other Topics; Instruments & Instrumentation
GA V29XR
UT WOS:000208781600004
ER

PT J
AU Welton, MD
AF Welton, Mark D.
TI In the Shadow of Sectarianism: Law, Shi'ism, and the Making of Modern
   Lebanon
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Welton, Mark D.] US Mil Acad, West Point, NY 10996 USA.
RP Welton, MD (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 1
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
J9 MIDDLE EAST J
JI Middle East J.
PD SPR
PY 2011
VL 65
IS 2
BP 338
EP 339
PG 2
WC Area Studies
SC Area Studies
GA V31XH
UT WOS:000208915800014
ER

PT J
AU Krzywinski, J
   Li, C
   Morris, M
   Conn, JE
   Lima, JB
   Povoa, MM
   Wilkerson, RC
AF Krzywinski, Jaroslaw
   Li, Cong
   Morris, Marion
   Conn, Jan E.
   Lima, Jose B.
   Povoa, Marinete M.
   Wilkerson, Richard C.
TI Analysis of the evolutionary forces shaping mitochondrial genomes of a
   Neotropical malaria vector complex
SO MOLECULAR PHYLOGENETICS AND EVOLUTION
LA English
DT Article
DE Comparative genomics; Mitochondrial genome evolution; Replication
   origin; Introgressive hybridization; Malaria vectors
ID POLYMERASE-CHAIN-REACTION; NYSSORHYNCHUS ALBITARSIS DIPTERA;
   ANOPHELES-GAMBIAE; GENE-SEQUENCES; PHYLOGENETIC-RELATIONSHIPS; REACTION
   IDENTIFICATION; MOLECULAR PHYLOGENY; CULICIDAE COMPLEX; DNA-SEQUENCE;
   INTROGRESSION
AB Many vectors of human malaria belong to complexes of morphologically indistinguishable cryptic species. Here we report the analysis of the newly sequenced complete mitochondrial DNA molecules from six recognized or putative species of one such group, the Neotropical Anopheles albitarsis complex. The molecular evolution of these genomes had been driven by purifying selection, particularly strongly acting on the RNA genes. Directional mutation pressure associated with the strand-asynchronous asymmetric mtDNA replication mechanism may have shaped a pronounced DNA strand asymmetry in the nucleotide composition in these and other Anopheles species. The distribution of sequence polymorphism, coupled with the conflicting phylogenetic trees inferred from the mitochondrial DNA and from the published white gene fragment sequences, indicates that the evolution of the complex may have involved ancient mtDNA introgression. Six protein coding genes (nad5, nad4, cox3, atp6, cox1 and nad2) have high levels of sequence divergence and are likely informative for population genetics studies. Finally, the extent of the mitochondrial DNA variation within the complex supports the notion that the complex consists of a larger number of species than until recently believed. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Krzywinski, Jaroslaw; Morris, Marion] Univ Liverpool, Liverpool Sch Trop Med, Vector Grp, Liverpool L3 5QA, Merseyside, England.
   [Li, Cong; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA.
   [Li, Cong; Wilkerson, Richard C.] Smithsonian Inst, Museum Support Ctr, Walter Reed Biosystemat Unit, WRAIR,MRC 534, Suitland, MD 20746 USA.
   [Conn, Jan E.] New York State Dept Hlth, Wadsworth Ctr, Griffin Lab, Slingerlands, NY 12159 USA.
   [Conn, Jan E.] SUNY Albany, Sch Publ Hlth, Dept Biomed Sci, Albany, NY 12201 USA.
   [Lima, Jose B.] Fundacao Oswaldo Cruz, Dept Entomol, Rio De Janeiro, Brazil.
   [Povoa, Marinete M.] Inst Evandro Chagas, Secao Parasitol, Lab Malaria, BR-67030000 Ananindeua, PA, Brazil.
RP Krzywinski, J (reprint author), Univ Liverpool, Liverpool Sch Trop Med, Vector Grp, Liverpool L3 5QA, Merseyside, England.
EM jarek@liv.ac.uk
OI Conn, Jan/0000-0002-5301-7020
FU National Institutes of Health (USA) [2R01AI54139]; Liverpool School of
   Tropical Medicine
FX We are grateful to Martin Donnelly for a constructive discussion on the
   issue of potential introgression. Comments and suggestions made by two
   anonymous reviewers and Stephen Cameron improved the shape of the
   manuscript. We thank John F. Ruiz for providing the An. albitarsis G
   white gene sequence for the current analysis. We also thank Laboratorio
   de Pesquisas Basicas at Instituto Evandro Chagas, Belem, Para state,
   Brazil for logistical support in the field. This study was funded by
   National Institutes of Health (USA) Grant 2R01AI54139 to JEC and by
   start-up funds from the Liverpool School of Tropical Medicine to JK.
   Material has been reviewed by the Walter Reed Army Institute of
   Research. There is no objection to its presentation and/or publication.
   The opinions or assertions contained herein are the private views of the
   author, and are not to be construed as official, or as reflecting true
   views of the Department of the Army or the Department of Defense. Parts
   of this research were performed at the Smithsonian Institution under a
   Memorandum of Understanding between the Walter Reed Army Institute of
   Research and the Smithsonian Institution, with institutional support
   provided by both organizations.
NR 68
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U1 1
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1055-7903
J9 MOL PHYLOGENET EVOL
JI Mol. Phylogenet. Evol.
PD MAR
PY 2011
VL 58
IS 3
BP 469
EP 477
DI 10.1016/j.ympev.2011.01.003
PG 9
WC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics &
   Heredity
SC Biochemistry & Molecular Biology; Evolutionary Biology; Genetics &
   Heredity
GA 731ZX
UT WOS:000288151000006
PM 21241811
ER

PT J
AU Lee, GL
   Dobi, A
   Srivastava, S
AF Lee, George Leighton
   Dobi, Albert
   Srivastava, Shiv
TI Diagnostic performance of the PCA3 urine test
SO NATURE REVIEWS UROLOGY
LA English
DT Editorial Material
ID PROSTATE-CANCER; REPEAT BIOPSY; MEN; ASSAY; GENE
AB The potential of the prostate cancer antigen 3 (PCA3) urine assay to aid prostate cancer diagnosis and minimize unnecessary biopsies has been extensively studied. Results from three recent studies that compared the performance of PCA3 with PSA underscore the advancement and future challenges for this new diagnostic biomarker.
C1 [Dobi, Albert; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA.
   [Lee, George Leighton] Walter Reed Army Med Ctr, Urol Serv, Dept Surg, Washington, DC 20307 USA.
RP Dobi, A (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20852 USA.
EM adobi@cpdr.org
NR 9
TC 56
Z9 64
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4812
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD MAR
PY 2011
VL 8
IS 3
BP 123
EP 124
DI 10.1038/nrurol.2011.10
PG 2
WC Urology & Nephrology
SC Urology & Nephrology
GA 733CQ
UT WOS:000288238400001
PM 21394175
ER

PT J
AU Yancosek, KE
   Howell, D
AF Yancosek, Kathleen E.
   Howell, Dana
TI Systematic Review of Interventions to Improve or Augment Handwriting
   Ability in Adult Clients
SO OTJR-OCCUPATION PARTICIPATION AND HEALTH
LA English
DT Review
DE handwriting; intervention; hand dominance; systematic review
ID CONSTRAINT-INDUCED MOVEMENT; THERAPY; STROKE; SCHOOL; RELIABILITY;
   PERFORMANCE; CHILDREN; STUDENTS; SCALE; HAND
AB This systematic review examined research related to interventions that addressed handwriting deficits in adults with impaired upper limb motor coordination resulting from central and peripheral nervous system injury or illness. The clinical question was, "Based on current research, what is/are the recommended intervention(s) to improve, augment, or replace handwriting skills among adult clients with upper limb motor deficits?" A research protocol was followed, which was modified to include pediatric literature after an initial search of interventions for adults proved limited. Four studies related to adults and 10 related to pediatrics were included in the review and all were evaluated for quality using standardized procedures. The adult studies addressed the use of voice recognition software and hand dominance transfer training. Available evidence for interventions with children with handwriting deficits centered around these clinical options: Cognition Orientation to Daily Occupational Performance, task-orientated self-instruction, ergonomic modifications to a desk, school-based intervention (emphasis on visual motor skills and practice), sensory diet with therapeutic listening, therapeutic practice, and a graphomotor program. Improvement in handwriting skill emerged from seven of the 10 pediatric studies. Direct practice of handwriting tasks was common to all successful studies and missing in studies that failed to show skill improvement. It may be logical to conclude that intervention strategies should include direct practice of handwriting, whether the client is an adult or a child. Further research on handwriting intervention programs specifically for adult clients and the inclusion of direct practice as intervention is warranted.
C1 [Yancosek, Kathleen E.] USA, Washington, DC 20310 USA.
   [Howell, Dana] Eastern Kentucky Univ, Dept Occupat Therapy, Richmond, KY 40475 USA.
RP Yancosek, KE (reprint author), USA, Washington, DC 20310 USA.
EM Kathleen.yancosek@us.army.mil
NR 36
TC 4
Z9 4
U1 3
U2 16
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1539-4492
J9 OTJR-OCCUP PART HEAL
JI OTJR-Occup. Particip. Health
PD SPR
PY 2011
VL 31
IS 2
BP 55
EP 63
DI 10.3928/15394492-20100722-03
PG 9
WC Rehabilitation
SC Rehabilitation
GA 746SY
UT WOS:000289268800003
ER

PT J
AU Moffett, MC
   Schultz, MK
   Schwartz, JE
   Stone, MF
   Lumley, LA
AF Moffett, Mark C.
   Schultz, Mark K.
   Schwartz, Julia E.
   Stone, Michael F.
   Lumley, Lucille A.
TI Impaired auditory and contextual fear conditioning in soman-exposed rats
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Soman; Fear conditioning; Thalamus; Hippocampus; Amygdala
ID SCHEDULE-CONTROLLED BEHAVIOR; LONG-TERM CONSEQUENCES; BRAIN
   ACETYLCHOLINESTERASE; EMOTIONAL BEHAVIOR; AMYGDALOID NUCLEUS; STATUS
   EPILEPTICUS; MOLECULAR-FORMS; MICE; MEMORY; NEUROPATHOLOGY
AB Exposure to soman (GD) can result in prolonged seizures and subsequent neuropathology in a variety of brain regions including the amygdala and hippocampus. Both regions are believed to play important roles in the development and expression of fear conditioning. The purpose of this experiment was to test these conditioning tasks as a possible behavioral correlate of the observed neuropathology. Male rats were exposed to GD (1.0 or 1.2 x LD(50)) or saline followed with injections of atropine sulfate, the oxime HI-6 and diazepam. Fear conditioning was conducted on post-exposure day (FED) 8 followed by measuring freezing to contextual and auditory conditioned stimuli on FED 9 and 10 respectively. Contextual and auditory fear conditioning was severely impaired in both the 1.0 x LD(50) and 1.2 x LD(50) GD groups. Both GD groups spent less time freezing than controls when returned to the context in which conditioning occurred. The 1.0 x LD(50) and 1.2 x LD(50) groups had very low levels of freezing following presentation of the auditory conditioned stimulus. Neuronal fiber degeneration was present in the piriform cortex, thalamus, and amygdala in GD-exposed animals regardless of dose. The present study suggests that contextual and auditory fear conditioning is impaired in GD-exposed rats possibly due to neuropathology observed in the hippocampus, amygdala and thalamus. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Moffett, Mark C.; Schultz, Mark K.; Schwartz, Julia E.; Stone, Michael F.; Lumley, Lucille A.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
RP Moffett, MC (reprint author), USAMRICD, APG EA, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM mark.moffett1@us.army.mil
FU Defense Threat Reduction Agency - Joint Science and Technology Office,
   Medical S&T Division & Physical Science Division
FX This research was supported by the Defense Threat Reduction Agency -
   Joint Science and Technology Office, Medical S&T Division & Physical
   Science Division (PI: Dr. Lucille Lumley).
NR 66
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U1 1
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD MAR
PY 2011
VL 98
IS 1
BP 120
EP 129
DI 10.1016/j.pbb.2010.11.022
PG 10
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA 735MY
UT WOS:000288420300017
PM 21144858
ER

PT J
AU Garcia-Rodriguez, C
   Geren, IN
   Lou, J
   Conrad, F
   Forsyth, C
   Wen, W
   Chakraborti, S
   Zao, H
   Manzanarez, G
   Smith, TJ
   Brown, J
   Tepp, WH
   Liu, N
   Wijesuriya, S
   Tomic, MT
   Johnson, EA
   Smith, LA
   Marks, JD
AF Garcia-Rodriguez, C.
   Geren, I. N.
   Lou, J.
   Conrad, F.
   Forsyth, C.
   Wen, W.
   Chakraborti, S.
   Zao, H.
   Manzanarez, G.
   Smith, T. J.
   Brown, J.
   Tepp, W. H.
   Liu, N.
   Wijesuriya, S.
   Tomic, M. T.
   Johnson, E. A.
   Smith, L. A.
   Marks, J. D.
TI Neutralizing human monoclonal antibodies binding multiple serotypes of
   botulinum neurotoxin
SO PROTEIN ENGINEERING DESIGN & SELECTION
LA English
DT Article
DE botulism; botulinum neurotoxin; molecular evolution; single-chain Fv;
   yeast display
ID TOXIN TYPE-A; MOLECULAR EVOLUTION; SURFACE DISPLAY; AFFINITY; PHAGE;
   LIBRARIES; DOMAIN; IDENTIFICATION; DIVERSITY; RECEPTOR
AB Botulism, a disease of humans characterized by prolonged paralysis, is caused by botulinum neurotoxins (BoNTs), the most poisonous substances known. There are seven serotypes of BoNT (A-G) which differ from each other by 34-64% at the amino acid level. Each serotype is uniquely recognized by polyclonal antibodies, which originally were used to classify serotypes. To determine if there existed monoclonal antibodies (mAbs) capable of binding two or more serotypes, we evaluated the ability of 35 yeast-displayed single-chain variable fragment antibodies generated from vaccinated humans or mice for their ability to bind multiple BoNT serotypes. Two such clonally related human mAbs (1B18 and 4E17) were identified that bound BoNT serotype A (BoNT/A) and B or BoNT/A, B, E and F, respectively, with high affinity. Using molecular evolution techniques, it proved possible to both increase affinity and maintain cross-serotype reactivity for the 4E17 mAb. Both 1B18 and 4E17 bound to a relatively conserved epitope at the tip of the BoNT translocation domain. Immunoglobulin G constructed from affinity matured variants of 1B18 and 4E17 were evaluated for their ability to neutralize BoNT/B and E, respectively, in vivo. Both antibodies potently neutralized BoNT in vivo demonstrating that this epitope is functionally important in the intoxication pathway. Such cross-serotype binding and neutralizing mAbs should simplify the development of antibody-based BoNT diagnostics and therapeutics.
C1 [Garcia-Rodriguez, C.; Geren, I. N.; Lou, J.; Conrad, F.; Forsyth, C.; Wen, W.; Chakraborti, S.; Zao, H.; Manzanarez, G.; Marks, J. D.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Anesthesia & Pharmaceut Chem, San Francisco, CA 94110 USA.
   [Smith, T. J.; Brown, J.; Smith, L. A.] USA, Integrated Toxicol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
   [Tepp, W. H.; Johnson, E. A.] Univ Wisconsin, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA.
   [Liu, N.; Wijesuriya, S.; Tomic, M. T.] XOMA US LLC, Berkeley, CA 94710 USA.
RP Marks, JD (reprint author), Univ Calif San Francisco, San Francisco Gen Hosp, Dept Anesthesia & Pharmaceut Chem, Rm 3C-38,1001 Potrero Ave, San Francisco, CA 94110 USA.
EM marksj@anesthesia.ucsf.edu
FU NIAID [U01 AI056493 (HHSN272200800028C)]; DoD [HDTRA1-07-C-0030];
   Centers for Disease Control and Prevention [200-2006-16697]
FX This work was partially supported by NIAID cooperative agreement U01
   AI056493 (HHSN272200800028C), DoD (HDTRA1-07-C-0030) and Centers for
   Disease Control and Prevention (200-2006-16697).
NR 42
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U1 1
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1741-0126
J9 PROTEIN ENG DES SEL
JI Protein Eng. Des. Sel.
PD MAR
PY 2011
VL 24
IS 3
BP 321
EP 331
DI 10.1093/protein/gzq111
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 723DM
UT WOS:000287486500010
PM 21149386
ER

PT J
AU Buchler, NG
   Faunce, P
   Light, LL
   Gottfredson, N
   Reder, LM
AF Buchler, Norbou G.
   Faunce, Paige
   Light, Leah L.
   Gottfredson, Nisha
   Reder, Lynne M.
TI Effects of Repetition on Associative Recognition in Young and Older
   Adults: Item and Associative Strengthening
SO PSYCHOLOGY AND AGING
LA English
DT Article
DE aging; associative recognition; recollection; familiarity; resource
   model
ID RECALL-TO-REJECT; RECEIVER-OPERATING CHARACTERISTICS; REMEMBER-KNOW
   JUDGMENTS; DUAL-PROCESS ACCOUNT; MEMORY PERFORMANCE; PREFRONTAL CORTEX;
   AGE-DIFFERENCES; RELATIONAL INFORMATION; DIVIDED ATTENTION; EPISODIC
   MEMORY
AB Young and older adults studied word pairs and later discriminated studied pairs from various types of foils including recombined word-pairs and foil pairs containing one or two previously unstudied words. We manipulated how many times a specific word pair was repeated (1 or 5) and how many different words were associated with a given word (1 or 5) to tease apart the effects of item familiarity from recollection of the association. Rather than making simple old/new judgments, subjects chose one of five responses: (a) Old-Old (original), (b) Old-Old (rearranged), (c) Old-New, (d) New-Old, (e) New-New. Veridical recollection was impaired in old age in all memory conditions. There was evidence for a higher rate of false recollection of rearranged pairs following exact repetition of study pairs in older but not younger adults. In contrast, older adults were not more susceptible to interference than young adults when one or both words of the pair had multiple competing associates. Older adults were just as able as young adults to use item familiarity to recognize which word of a foil was old. This pattern suggests that recollection problems in advanced age are because of a deficit in older adults' formation or retrieval of new associations in memory. A modeling simulation provided good fits to these data and offers a mechanistic explanation based on an age-related reduction of working memory.
C1 [Buchler, Norbou G.] USA, RDRL HRS E, Res Lab, Cognit Sci Branch, Aberdeen Proving Ground, MD 21005 USA.
   [Buchler, Norbou G.; Faunce, Paige; Reder, Lynne M.] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Light, Leah L.; Gottfredson, Nisha] Pitzer Coll, Dept Psychol, Claremont, CA 91711 USA.
RP Buchler, NG (reprint author), USA, RDRL HRS E, Res Lab, Cognit Sci Branch, Aberdeen Proving Ground, MD 21005 USA.
EM norbou.buchler@arl.army.mil
FU NIMH NIH HHS [MH052808-08, R01 MH052808, R01 MH052808-03,
   5T32-MH019983-07, T32 MH019983]; PHS HHS [AGO 2452]
NR 76
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Z9 10
U1 3
U2 8
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0882-7974
EI 1939-1498
J9 PSYCHOL AGING
JI Psychol. Aging
PD MAR
PY 2011
VL 26
IS 1
BP 111
EP 126
DI 10.1037/a0020816
PG 16
WC Gerontology; Psychology, Developmental
SC Geriatrics & Gerontology; Psychology
GA 737TJ
UT WOS:000288590800011
PM 20973609
ER

PT J
AU Gadisetti, C
   Shoji, Y
   Maxwell, GL
   Risinger, JI
AF Gadisetti, Chandramouli
   Shoji, Yutaka
   Maxwell, G. Larry
   Risinger, John I.
TI The miR-342-5p micro RNA Is Associated with Obesity in Endometrial
   Cancer
SO REPRODUCTIVE SCIENCES
LA English
DT Meeting Abstract
C1 [Gadisetti, Chandramouli; Shoji, Yutaka; Risinger, John I.] Michigan State Univ, Grand Rapids, MI USA.
   [Maxwell, G. Larry] Walter Reed Army Med Ctr, Div Gynecol Oncol, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
J9 REPROD SCI
JI Reprod. Sci.
PD MAR
PY 2011
VL 18
IS 3
SU S
MA T304
BP 157A
EP 157A
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 778RE
UT WOS:000291721700306
ER

PT J
AU Segrest, S
AF Segrest, Scott
TI Human Rights, Legitimacy, and the Use of Force
SO REVIEW OF METAPHYSICS
LA English
DT Book Review
C1 [Segrest, Scott] US Mil Acad, West Point, NY 10996 USA.
RP Segrest, S (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU CATHOLIC UNIV AMER PRESS
PI WASHINGTON
PA 620 MICHIGAN AVENUE NE ADMIN BLDG ROOM 303, WASHINGTON, DC 20064 USA
SN 0034-6632
J9 REV METAPHYS
JI Rev. Metaphys.
PD MAR
PY 2011
VL 64
IS 3
BP 630
EP 632
PG 3
WC Philosophy
SC Philosophy
GA 746CN
UT WOS:000289219800012
ER

PT J
AU Brown, RS
   Eppard, MB
   Murchie, KJ
   Nielsen, JL
   Cooke, SJ
AF Brown, Richard S.
   Eppard, M. Brad
   Murchie, Karen J.
   Nielsen, Jennifer L.
   Cooke, Steven J.
TI An introduction to the practical and ethical perspectives on the need to
   advance and standardize the intracoelomic surgical implantation of
   electronic tags in fish
SO REVIEWS IN FISH BIOLOGY AND FISHERIES
LA English
DT Editorial Material
DE Surgery; Tagging; Transmitter; Telemetry
ID TELEMETRY TRANSMITTERS; BIOTELEMETRY; RESEARCHERS; RETENTION; OPINIONS;
   BEHAVIOR; ECOLOGY; SALMON
AB The intracoelomic surgical implantation of electronic tags (including radio and acoustic telemetry transmitters, passive integrated transponders and archival biologgers) is frequently used for conducting studies on fish. Electronic tagging studies provide information on the spatial ecology, behavior and survival of fish in marine and freshwater systems. However, any surgical procedure, particularly one where a laparotomy is performed and the coelomic cavity is opened, has the potential to alter the survival, behavior or condition of the animal which can impair welfare and introduce bias. Given that management, regulatory and conservation decisions are based on the assumption that fish implanted with electronic tags have similar fates and behavior relative to untagged conspecifics, it is critical to ensure that best surgical practices are being used. Also, the current lack of standardized surgical procedures and reporting of specific methodological details precludes cross-study and cross-year analyses which would further progress the field of fisheries science. This compilation of papers seeks to identify the best practices for the entire intracoelomic tagging procedure including pre- and post-operative care, anesthesia, wound closure, and use of antibiotics. Although there is a particular focus on salmonid smolts given the large body of literature available on that group, other life-stages and species of fish are discussed where there is sufficient knowledge. Additional papers explore the role of the veterinarian in fish surgeries, the need for minimal standards in the training of fish surgeons, providing a call for more complete and transparent procedures, and identifying trends in procedures and research needs. Collectively, this body of knowledge should help to improve data quality (including comparability and repeatability), enhance management and conservation strategies, and maintain the welfare status of tagged fish.
C1 [Brown, Richard S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
   [Eppard, M. Brad] US Army Corps Engineers, Portland, OR 97208 USA.
   [Murchie, Karen J.; Cooke, Steven J.] Carleton Univ, Dept Biol, Fish Ecol & Conservat Physiol Lab, Ottawa, ON K1S 5B6, Canada.
   [Murchie, Karen J.; Cooke, Steven J.] Carleton Univ, Inst Environm Sci, Ottawa, ON K1S 5B6, Canada.
   [Nielsen, Jennifer L.] US Geol Survey, Alaska Sci Ctr, Anchorage, AK 99508 USA.
RP Brown, RS (reprint author), Pacific NW Natl Lab, Ecol Grp, 902 Battelle Blvd,POB 999,MSIN K6-85, Richland, WA 99352 USA.
EM rich.brown@pnl.gov
RI Cooke, Steven/F-4193-2010
OI Cooke, Steven/0000-0002-5407-0659
NR 34
TC 10
Z9 10
U1 2
U2 30
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0960-3166
EI 1573-5184
J9 REV FISH BIOL FISHER
JI Rev. Fish. Biol. Fish.
PD MAR
PY 2011
VL 21
IS 1
SI SI
BP 1
EP 9
DI 10.1007/s11160-010-9183-5
PG 9
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 726WG
UT WOS:000287756700001
ER

PT J
AU Cooke, SJ
   Woodley, CM
   Eppard, MB
   Brown, RS
   Nielsen, JL
AF Cooke, Steven J.
   Woodley, Christa M.
   Eppard, M. Brad
   Brown, Richard S.
   Nielsen, Jennifer L.
TI Advancing the surgical implantation of electronic tags in fish: a gap
   analysis and research agenda based on a review of trends in
   intracoelomic tagging effects studies
SO REVIEWS IN FISH BIOLOGY AND FISHERIES
LA English
DT Review
DE Surgery; Biotelemetry; Behavior; Electronic tags
ID JUVENILE CHINOOK SALMON; PASSIVE INTEGRATED TRANSPONDERS; IMPLANTING
   RADIO TRANSMITTERS; DUMMY ACOUSTIC TRANSMITTERS; ATLANTIC BLUEFIN TUNA;
   CARP CYPRINUS-CARPIO; HYBRID STRIPED BASS; LONG-TERM RETENTION; SWIMMING
   PERFORMANCE; RAINBOW-TROUT
AB Early approaches to surgical implantation of electronic tags in fish were often through trial and error, however, in recent years there has been an interest in using scientific research to identify techniques and procedures that improve the outcome of surgical procedures and determine the effects of tagging on individuals. Here we summarize the trends in 108 peer-reviewed electronic tagging effect studies focused on intracoleomic implantation to determine opportunities for future research. To date, almost all of the studies have been conducted in freshwater, typically in laboratory environments, and have focused on biotelemetry devices. The majority of studies have focused on salmonids, cyprinids, ictalurids and centrarchids, with a regional bias towards North America, Europe and Australia. Most studies have focused on determining whether there is a negative effect of tagging relative to control fish, with proportionally fewer that have contrasted different aspects of the surgical procedure (e.g., methods of sterilization, incision location, wound closure material) that could advance the discipline. Many of these studies included routine endpoints such as mortality, growth, healing and tag retention, with fewer addressing sublethal measures such as swimming ability, predator avoidance, physiological costs, or fitness. Continued research is needed to further elevate the practice of electronic tag implantation in fish in order to ensure that the data generated are relevant to untagged conspecifics (i.e., no long-term behavioural or physiological consequences) and the surgical procedure does not impair the health and welfare status of the tagged fish. To that end, we advocate for (1) rigorous controlled manipulations based on statistical designs that have adequate power, account for inter-individual variation, and include controls and shams, (2) studies that transcend the laboratory and the field with more studies in marine waters, (3) incorporation of knowledge and techniques emerging from the medical and veterinary disciplines, (4) addressing all components of the surgical event, (5) comparative studies that evaluate the same surgical techniques on multiple species and in different environments, (6) consideration of how biotic factors (e.g., sex, age, size) influence tagging outcomes, and (7) studies that cover a range of endpoints over ecologically relevant time periods.
C1 [Cooke, Steven J.] Carleton Univ, Dept Biol, Fish Ecol & Conservat Physiol Lab, Ottawa, ON K1S 5B6, Canada.
   [Cooke, Steven J.] Carleton Univ, Inst Environm Sci, Ottawa, ON K1S 5B6, Canada.
   [Woodley, Christa M.; Brown, Richard S.] Pacific NW Natl Lab, Ecol Grp, Richland, WA 99352 USA.
   [Eppard, M. Brad] US Army Corps Engineers, Portland Dist Off, Portland, OR USA.
   [Nielsen, Jennifer L.] US Geol Survey, Alaska Sci Ctr, Anchorage, AK 99508 USA.
RP Cooke, SJ (reprint author), Carleton Univ, Dept Biol, Fish Ecol & Conservat Physiol Lab, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada.
EM Steven_Cooke@carleton.ca
RI Cooke, Steven/F-4193-2010
OI Cooke, Steven/0000-0002-5407-0659
FU United States Army Corps of Engineers, Portland District under Pacific
   Northwest National Laboratory [DE-AC05-76RL01830]
FX Cooke was supported by the United States Army Corps of Engineers,
   Portland District under contract from the Pacific Northwest National
   Laboratory (Contract # DE-AC05-76RL01830). Additional support was
   provided by Carleton University, the Canada Research Chairs Program, and
   the Ocean Telemetry Network Canada. Chris Holbrook, Karen Murchie and an
   anonymous referee kindly provided comments on the manuscript. Any
   reference to trade names does not indicate endorsement by the US Federal
   Government.
NR 134
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U1 2
U2 52
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0960-3166
EI 1573-5184
J9 REV FISH BIOL FISHER
JI Rev. Fish. Biol. Fish.
PD MAR
PY 2011
VL 21
IS 1
SI SI
BP 127
EP 151
DI 10.1007/s11160-010-9193-3
PG 25
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA 726WG
UT WOS:000287756700012
ER

PT J
AU Maddox, WT
   Glass, BD
   Zeithamova, D
   Savarie, ZR
   Bowen, C
   Matthews, MD
   Schnyer, DM
AF Maddox, W. Todd
   Glass, Brian D.
   Zeithamova, Dagmar
   Savarie, Zachary R.
   Bowen, Christopher
   Matthews, Michael D.
   Schnyer, David M.
TI The Effects of Sleep Deprivation on Dissociable Prototype Learning
   Systems
SO SLEEP
LA English
DT Article
DE Prototype learning; perceptual learning; episodic memory; sleep
   deprivation; attention
ID FUNCTIONAL MRI; PROACTIVE-INTERFERENCE; CATEGORY; CATEGORIZATION;
   PERFORMANCE; FATIGUE; MEMORY; RECOGNITION; MECHANISMS; DISEASE
AB Background: The cognitive neural underpinnings of prototype learning are becoming clear. Evidence points to 2 different neural systems, depending on the learning parameters. A/not-A (AN) prototype learning is mediated by posterior brain regions that are involved in early perceptual learning, whereas A/B (AB) is mediated by frontal and medial temporal lobe regions.
   Study Objectives: To investigate the effects of sleep deprivation on AN and AB prototype learning and to use established prototype models to provide insights into the cognitive-processing locus of sleep-deprivation deficits.
   Design: Participants performed an AN and an AB prototype learning task twice, separated by a 24-hour period, with or without sleep between testing sessions.
   Participants: Eighteen West Point cadets participated in the sleep-deprivation group, and 17 West Point cadets participated in a control group.
   Measurements and Results: Sleep deprivation led to an AN, but not an AB, performance deficit. Prototype model analyses indicated that the AN deficit was due to changes in attentional focus and a decrease in confidence that is reflected in an increased bias to respond non-A.
   Conclusions: The findings suggest that AN, but not AB, prototype learning is affected by sleep deprivation. Prototype model analyses support the notion that the effect of sleep deprivation on AN is consistent with lapses in attentional focus that are more detrimental to AN than to AB. This finding adds to a growing body of work that suggests that different performance changes associated with sleep deprivation can be attributed to a common mechanism of changes in simple attention and vigilance.
C1 [Maddox, W. Todd; Glass, Brian D.; Schnyer, David M.] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.
   [Maddox, W. Todd; Zeithamova, Dagmar; Schnyer, David M.] Univ Texas Austin, Inst Neurosci, Austin, TX 78712 USA.
   [Maddox, W. Todd] Univ Texas Austin, Ctr Perceptual Syst, Austin, TX 78712 USA.
   [Savarie, Zachary R.; Bowen, Christopher; Matthews, Michael D.] US Mil Acad, West Point, NY 10996 USA.
RP Maddox, WT (reprint author), Univ Texas Austin, Dept Psychol, 1 Univ Stn A8000, Austin, TX 78712 USA.
EM maddox@psy.utexas.edu
FU NIH [R01 MH077708]; Center for Strategic and Innovative Technologies at
   The University of Texas at Austin [W911NF-07-2-0023]
FX This research was supported by NIH Grant R01 MH077708 to WTM and the
   Army Grant W911NF-07-2-0023, through The Center for Strategic and
   Innovative Technologies at The University of Texas at Austin, to WTM and
   DMS. We thank Andrea Bozoki for providing us with the basis for the
   stimulus sets and Sean Maddox, Borami Lee, and Cristina Benavides for
   developing the rest of the stimulus sets.
NR 44
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Z9 5
U1 2
U2 4
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 0161-8105
J9 SLEEP
JI Sleep
PD MAR 1
PY 2011
VL 34
IS 3
BP 253
EP 260
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA 729AK
UT WOS:000287917600005
PM 21358842
ER

PT J
AU Wolters, MS
   Martin, CO
AF Wolters, Monica S.
   Martin, Chester O.
TI Observations of Parturition in Rafinesque's Big-eared Bats (Corynorhinus
   rafinesquii) Beneath a Concrete Bridge
SO SOUTHEASTERN NATURALIST
LA English
DT Article
ID LOUISIANA; SELECTION
AB We report on observations of parturition and maternal behavior of Corynorhinus rafinesquii (Rafinesque's Big-eared Bat) at a bridge in west-central Mississippi. Rafinesque's Big-eared Bats formed a maternity colony beneath the bridge in March, and parturition occurred from late May to early June. On 28 May 2004, a female Rafinesque's Big-eared Bat was observed giving birth in the breech position, which has not been previously reported for the species. On the same day, another adult female and her pup were found struggling on the ground due to entanglement of the umbilical cord around the mother's wing, and a third female was observed biting her pup. While important data were obtained during our observations, we emphasize the necessity of using extreme care when conducting repeated surveys at maternity roost sites.
C1 [Martin, Chester O.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Wolters, Monica S.] Mississippi Coll, Dept Educ, Clinton, MS 39056 USA.
RP Martin, CO (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM chester.o.martin@usace.army.mil
NR 14
TC 0
Z9 0
U1 2
U2 11
PU HUMBOLDT FIELD RESEARCH INST
PI STEUBEN
PA PO BOX 9, STEUBEN, ME 04680-0009 USA
SN 1528-7092
J9 SOUTHEAST NAT
JI Southeast. Nat.
PD MAR
PY 2011
VL 10
IS 1
BP 178
EP 180
DI 10.1656/058.010.0115
PG 3
WC Biodiversity Conservation; Ecology
SC Biodiversity & Conservation; Environmental Sciences & Ecology
GA 976RB
UT WOS:000306600900015
ER

PT J
AU Wei, G
   Lu, XCM
   Shear, DA
   Yang, XF
   Tortella, FC
AF Wei, Guo
   Lu, Xi-Chun M.
   Shear, Deborah A.
   Yang, Xiaofang
   Tortella, Frank C.
TI Neuroprotection of Selective Brain Cooling After Penetrating
   Ballistic-like Brain Injury in Rats
SO THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT
LA English
DT Article
AB Induced hypothermia has been reported to provide neuroprotection against traumatic brain injury. We recently developed a novel method of selective brain cooling (SBC) and demonstrated its safety and neuroprotection efficacy in a rat model of ischemic brain injury. The primary focus of the current study was to evaluate the potential neuroprotective efficacy of SBC in a rat model of penetrating ballistic-like brain injury (PBBI) with a particular focus on the acute cerebral pathophysiology, neurofunction, and cognition. SBC (34 degrees C) was induced immediately after PBBI, and maintained for 2 hours, followed by a spontaneous re-warming. Intracranial pressure (ICP) and regional cerebral blood flow were monitored continuously for 3 hours, and the ICP was measured again at 24 hours postinjury. Brain swelling, blood-brain barrier permeability, intracerebral hemorrhage, lesion size, and neurological status were assessed at 24 hours postinjury. Cognitive abilities were evaluated in a Morris water maze task at 12-16 days postinjury. Results showed that SBC significantly attenuated PBBI-induced elevation of ICP (PBBI = 33.2 +/- 10.4; PBBI + SBC = 18.8 +/- 6.7 mmHg) and reduced brain swelling, blood-brain barrier leakage, intracerebral hemorrhage, and lesion volume by 40%-45% for each matrix, and significantly improved neurologic function. However, these acute neuroprotective benefits of SBC did not translate into improved cognitive performance in the Morris water maze task. These results indicate that 34 degrees C SBC is effective in protecting against acute brain damage and related neurological dysfunction. Further studies are required to establish the optimal treatment conditions (i.e., duration of cooling and/or combined therapeutic approaches) needed to achieve significant neurocognitive benefits.
C1 [Wei, Guo; Lu, Xi-Chun M.; Shear, Deborah A.; Yang, Xiaofang; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA.
RP Wei, G (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM guo.wei@us.army.mil
FU U.S. Army Medical Research and Materiel Command, Combat Casualty Care
   Research Program
FX This work was supported by core funding provided by the U.S. Army
   Medical Research and Materiel Command, Combat Casualty Care Research
   Program.
NR 61
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U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-7658
EI 2153-7933
J9 THER HYPOTHERMIA TEM
JI Ther. Hypothermia Temp. Manag.
PD MAR 1
PY 2011
VL 1
IS 1
BP 33
EP 42
DI 10.1089/ther.2010.0007
PG 10
WC Critical Care Medicine
SC General & Internal Medicine
GA V38PS
UT WOS:000209355900002
PM 24716886
ER

PT J
AU Ruthel, G
   Burnett, JC
   Nuss, JE
   Wanner, LM
   Tressler, LE
   Torres-Melendez, E
   Sandwick, SJ
   Retterer, CJ
   Bavari, S
AF Ruthel, Gordon
   Burnett, James C.
   Nuss, Jonathan E.
   Wanner, Laura M.
   Tressler, Lyal E.
   Torres-Melendez, Edna
   Sandwick, Sarah J.
   Retterer, Cary J.
   Bavari, Sina
TI Post-Intoxication Inhibition of Botulinum Neurotoxin Serotype A within
   Neurons by Small-Molecule, Non-Peptidic Inhibitors
SO TOXINS
LA English
DT Article
DE botulinum neurotoxin; small molecule non-peptidic inhibitor;
   neutralizing antibody; Bafilomycin A1
ID TOXIN; IDENTIFICATION; EXOCYTOSIS
AB Botulinum neurotoxins (BoNTs) comprise seven distinct serotypes that inhibit the release of neurotransmitter across neuromuscular junctions, resulting in potentially fatal flaccid paralysis. BoNT serotype A (BoNT/A), which targets synaptosomal-associated protein of 25kDa (SNAP-25), is particularly long-lived within neurons and requires a longer time for recovery of neuromuscular function. There are currently no treatments available to counteract BoNT/A after it has entered the neuronal cytosol. In this study, we examined the ability of small molecule non-peptidic inhibitors (SMNPIs) to prevent SNAP-25 cleavage post-intoxication of neurons. The progressive cleavage of SNAP-25 observed over 5 h following 1 h BoNT/A intoxication was prevented by addition of SMNPIs. In contrast, anti-BoNT/A neutralizing antibodies that strongly inhibited SNAP-25 cleavage when added during intoxication were completely ineffective when added post-intoxication. Although Bafilomycin A1, which blocks entry of BoNT/A into the cytosol by preventing endosomal acidification, inhibited SNAP-25 cleavage post-intoxication, the degree of inhibition was significantly reduced versus addition both during and after intoxication. Post-intoxication application of SMNPIs, on the other hand, was nearly as effective as application both during and after intoxication. Taken together, the results indicate that competitive SMNPIs of BoNT/A light chain can be effective within neurons post-intoxication.
C1 [Ruthel, Gordon; Nuss, Jonathan E.; Wanner, Laura M.; Tressler, Lyal E.; Torres-Melendez, Edna; Sandwick, Sarah J.; Retterer, Cary J.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
   [Burnett, James C.] NCI, SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA.
RP Ruthel, G (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA.
EM gordon.ruthel@amedd.army.mil; burnettjames@mail.nih.gov;
   jonathan.nuss@amedd.army.mil; laura.wanner@amedd.army.mil;
   lyal.tressler@amedd.army.mil; edna.torres-melendez@amedd.army.mil;
   sarah.sandwick@uni-wuerzburg.de; cary.retterer@amedd.army.mil;
   sina.bavari@amedd.army.mil
FU Joint Science and Technology Office, Defense Threat Reduction Agency
   [3.10084_09_RD_B]; National Cancer Institute, National Institutes of
   Health [HHSN261200800001E]
FX This research was funded by the Joint Science and Technology Office,
   Defense Threat Reduction Agency (Project 3.10084_09_RD_B). Opinions,
   interpretations, conclusions, and recommendations are those of the
   authors and are not necessarily endorsed by the U.S. Army. Furthermore,
   for JCB, in compliance with SAIC-Frederick, Inc. contractual
   requirements: this project has been funded in part with federal funds
   from the National Cancer Institute, National Institutes of Health, under
   Contract No. HHSN261200800001E. The content of this publication does not
   necessarily reflect the views or policies of the Department of Health
   and Human Services, nor does mention of trade names, commercial
   products, or organizations imply endorsement by the U.S. Government or
   the U.S. Army.
NR 17
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U1 0
U2 2
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD MAR
PY 2011
VL 3
IS 3
BP 207
EP 217
DI 10.3390/toxins3030207
PG 11
WC Toxicology
SC Toxicology
GA 994ZP
UT WOS:000307975400005
PM 22069707
ER

PT J
AU Goldberg, L
   McIntosh, C
   Cole, B
AF Goldberg, Lew
   McIntosh, Chris
   Cole, Brian
TI VCSEL end-pumped passively Q-switched Nd:YAG laser with adjustable pulse
   energy
SO OPTICS EXPRESS
LA English
DT Article
ID SURFACE-EMITTING LASERS; ND-YAG LASER; SATURABLE ABSORBER; MODEL
AB A compact, passively Q-switched Nd:YAG laser utilizing a Cr4+:YAG saturable absorber, is end-pumped by the focused emission from an 804 nm vertical-cavity surface-emitting laser (VCSEL) array. By changing the VCSEL operating current, we demonstrated 2x adjustability in the laser output pulse energy, from 9 mJ to 18 mJ. This energy variation was attributed to changes in the angular distribution of VCSEL emission with drive current, resulting in a change in the pump intensity distribution generated by a pump-light-focusing lens. (C) 2011 Optical Society of America
C1 [Goldberg, Lew; McIntosh, Chris; Cole, Brian] USA, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
RP Goldberg, L (reprint author), USA, RDECOM CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM lew.goldberg@us.army.mil
NR 17
TC 17
Z9 19
U1 1
U2 4
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD FEB 28
PY 2011
VL 19
IS 5
BP 4261
EP 4267
DI 10.1364/OE.19.004261
PG 7
WC Optics
SC Optics
GA 741NL
UT WOS:000288870300049
PM 21369256
ER

PT J
AU VanLeeuwen, BK
   Darling, KA
   Koch, CC
   Scattergood, RO
AF VanLeeuwen, Brian K.
   Darling, Kristopher A.
   Koch, Carl C.
   Scattergood, Ron O.
TI Novel technique for the synthesis of ultra-fine porosity metal foam via
   the inclusion of condensed argon through cryogenic mechanical alloying
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
   MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Metal foam; Cryogenic temperatures; Mechanical milling; Copper; Porosity
ID DUCTILE CELLULAR SOLIDS; AL-MG ALLOY; POROUS NITI; FILLED PORES;
   SUPERPLASTIC EXPANSION; ALUMINUM FOAMS; TRANSFORMATION BEHAVIOR; THERMAL
   HISTORY; GRAIN-GROWTH; PART II
AB It was discovered that mechanical milling of metal powders in an ultra high purity argon atmosphere at cryogenic temperatures can result in argon being incorporated into the metal. This incorporated argon causes expansion by increasing the porosity when the material is annealed. The resulting annealed material can be classified as metal foam due to its highly porous nature. The most porous samples were measured to have nearly 50% porosity. This effect was observed in nominally pure copper and an alloy of 81 at% palladium and 19 at% zirconium. (C) 2010 Elsevier B.V. All rights reserved.
C1 [VanLeeuwen, Brian K.; Koch, Carl C.; Scattergood, Ron O.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
   [Darling, Kristopher A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
RP VanLeeuwen, BK (reprint author), Penn State Univ, 121 Steidle Bldg, University Pk, PA 16802 USA.
EM bkv5016@psu.edu
FU National Science Foundation [0504286]
FX The authors thank the National Science Foundation for support (DMR Grant
   no. 0504286). The authors also thank Mark Atwater for providing some of
   the initial cryomilled copper powder and Dr. David Dunand and Dr. Scott
   Oppenhiemer for their advice and discussions.
NR 48
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U1 2
U2 9
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD FEB 25
PY 2011
VL 528
IS 4-5
BP 2192
EP 2195
DI 10.1016/j.msea.2010.11.057
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
   Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
   Metallurgical Engineering
GA 716UL
UT WOS:000286998900037
ER

PT J
AU Zheng, BL
   Ertorer, O
   Li, Y
   Zhou, YZ
   Mathaudhu, SN
   Tsao, CYA
   Lavernia, EJ
AF Zheng, Baolong
   Ertorer, Osman
   Li, Ying
   Zhou, Yizhang
   Mathaudhu, Suveen N.
   Tsao, Chi Y. A.
   Lavernia, Enrique J.
TI High strength, nano-structured Mg-Al-Zn alloy
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
   MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Magnesium alloys; Nanocrystalline microstructure; Mechanical milling;
   Sintering
ID MECHANICAL-PROPERTIES; PLASTIC-DEFORMATION; MAGNESIUM ALLOYS;
   GRAIN-GROWTH; MICROSTRUCTURAL EVOLUTION; NANOSTRUCTURED MATERIALS;
   BEHAVIOR; TEMPERATURE; ULTRAFINE; BOUNDARY
AB The mechanical behavior and microstructure of nanocrystalline (nc) Mg AZ80 alloy, synthesized via a cryomilling and spark plasma sintering (SPS) approach are reported and discussed. The effects of cryomilling processing on chemistry, particle morphology, and microstructure of the Mg alloy powder are described and discussed. The experimental results show that cryomilling for 8 h yields nc Mg agglomerates. approximately 30 mu m in size, with an internal average grain size of approximately 40 nm. The mechanisms that are thought to be responsible for deformation twins that were observed in the cryomilled AZ80 powder are discussed. The cryomilled Mg powder was subsequently consolidated using SPS at 250, 300 and 350 degrees C. The consolidated material consisted of a bimodal microstructure with nc fine and coarse grains formed in the SPS'ed Mg AZ80 microstructure. Inside of the coarse grains, nano-sized Mg(17)Al(12) precipitates were observed. A maximum microhardness of 140 HV, compressive yield strength of 442.3 MPa, and ultimate strength of 546 MPa are measured, which compare favorably to published values for conventional Mg alloys. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Zheng, Baolong; Ertorer, Osman; Li, Ying; Zhou, Yizhang; Lavernia, Enrique J.] Univ Calif Davis, Dept Chem Eng Mater Sci, Davis, CA 95616 USA.
   [Mathaudhu, Suveen N.] USA, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
   [Tsao, Chi Y. A.] Natl Cheng Kung Univ, Dept Mater Sci Eng, Tainan 70101, Taiwan.
   [Tsao, Chi Y. A.] Natl Cheng Kung Univ, Frontier Mat & Micro Nano Sci & Technol Ctr, Tainan 70101, Taiwan.
RP Lavernia, EJ (reprint author), Univ Calif Davis, Dept Chem Eng Mater Sci, 1 Shields Ave, Davis, CA 95616 USA.
EM lavernia@ucdavis.edu
RI Li, Ying/G-3908-2010; Mathaudhu, Suveen/B-4192-2009; Lavernia,
   Enrique/I-6472-2013
OI Li, Ying/0000-0003-3738-9307; Lavernia, Enrique/0000-0003-2124-8964
FU US Army Research Office [W911NF-06-1-0230]
FX The authors acknowledge the financial support provided by the US Army
   Research Office (Grant No. W911NF-06-1-0230).
NR 67
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U1 7
U2 50
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD FEB 25
PY 2011
VL 528
IS 4-5
BP 2180
EP 2191
DI 10.1016/j.msea.2010.11.073
PG 12
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
   Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
   Metallurgical Engineering
GA 716UL
UT WOS:000286998900036
ER

PT J
AU Choudhury, N
   Walizer, L
   Lisenkov, S
   Bellaiche, L
AF Choudhury, Narayani
   Walizer, Laura
   Lisenkov, Sergey
   Bellaiche, L.
TI Geometric frustration in compositionally modulated ferroelectrics
SO NATURE
LA English
DT Article
ID CHOLESTERIC BLUE PHASE; SUPERCONDUCTIVITY; SUPERLATTICES; MULTIFERROICS;
   CURVATURE; DIAGRAMS; GLASSES; PHYSICS; OXIDES; STATE
AB Geometric frustration is a broad phenomenon that results from an intrinsic incompatibility between some fundamental interactions and the underlying lattice geometry(1-7). Geometric frustration gives rise to new fundamental phenomena and is known to yield intriguing effects such as the formation of exotic states like spin ice, spin liquids and spin glasses(1-17). It has also led to interesting findings of fractional charge quantization and magnetic monopoles(5,6). Mechanisms related to geometric frustration have been proposed to understand the origins of relaxor and multiferroic behaviour, colossal magneto-capacitive coupling, and unusual and novel mechanisms of high-transition-temperature superconductivity(3-5,12,16). Although geometric frustration has been particularly well studied in magnetic systems in the past 20 years or so, its manifestation in the important class formed by ferroelectric materials (which are compounds with electric rather than magnetic dipoles) is basically unknown. Here we show, using a technique based on first principles, that compositionally graded ferroelectrics possess the characteristic 'fingerprints' associated with geometric frustration. These systems have a highly degenerate energy surface and display critical phenomena. They further reveal exotic orderings with novel stripe phases involving complex spatial organization. These stripes display spiral states, topological defects and curvature. Compositionally graded ferroelectrics can thus be considered the 'missing link' that brings ferroelectrics into the broad category of materials able to exhibit geometric frustration. Our ab initio calculations allow deep microscopic insight into this novel geometrically frustrated system.
C1 [Choudhury, Narayani; Bellaiche, L.] Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA.
   [Walizer, Laura] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Lisenkov, Sergey] Univ S Florida, Dept Phys, Tampa, FL 33620 USA.
RP Choudhury, N (reprint author), Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA.
EM narayani@uark.edu
RI Lisenkov, Sergey/C-4337-2012
FU US National Science Foundation; Office of Naval Research; Department of
   Energy
FX This work was supported by the US National Science Foundation, Office of
   Naval Research and Department of Energy. We gratefully acknowledge
   extensive use of the supercomputing resources of the University of
   Arkansas High Performance Computing Center as well as the Center for
   Piezoelectrics by Design, College of William and Mary, Virginia. We
   thank A. Apon, D. Chaffin, J. Pummill and E. J. Walter for computational
   support.
NR 30
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U1 11
U2 112
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
J9 NATURE
JI Nature
PD FEB 24
PY 2011
VL 470
IS 7335
BP 513
EP 517
DI 10.1038/nature09752
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 725NT
UT WOS:000287652900037
PM 21307851
ER

PT J
AU McAndrew, PM
   Wilken, JM
   Dingwell, JB
AF McAndrew, Patricia M.
   Wilken, Jason M.
   Dingwell, Jonathan B.
TI Dynamic stability of human walking in visually and mechanically
   destabilizing environments
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Walking; Dynamic stability; Optic flow; Walking surface; Perturbation;
   Virtual reality
ID LATERAL STABILIZATION; GAIT STABILITY; VARIABILITY; BALANCE; ADULTS;
   SPEED; SENSITIVITY; LOCOMOTION; KINEMATICS; SURFACE
AB Understanding how humans remain stable during challenging locomotor activities is critical to developing effective tests to diagnose patients with increased fall risk. This study determined if different continuous low-amplitude perturbations would induce specific measureable changes in measures of dynamic stability during walking. We applied continuous pseudo-random oscillations of either the visual scene or support surface in either the anterior-posterior or mediolateral directions to subjects walking in a virtual environment with speed-matched optic flow. Floquet multipliers and short-term local divergence exponents both increased (indicating greater instability) during perturbed walking. These responses were generally much stronger for body movements occurring in the same directions as the applied perturbations. Likewise, subjects were more sensitive to both visual and mechanical perturbations applied in the mediolateral direction than to those applied in the anterior-posterior direction, consistent with previous experiments and theoretical predictions. These responses were likewise consistent with subjects' anecdotal perceptions of which perturbation conditions were most challenging. Contrary to the Floquet multipliers and short-term local divergence exponents, which both increased, long-term local divergence exponenets decreased during perturbed walking. However, this was consistent with specific changes in the mean log divergence curves, which indicated that subjects' movements reached their maximum local divergence limits more quickly during perturbed walking. Overall, the Floquet multipliers were less sensitive, but reflected greater specificity in their responses to the different perturbation conditions. Conversely, the short-term local divergence exponents exhibited less specificity in their responses, but were more sensitive measures of instability in general. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
   [McAndrew, Patricia M.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA.
   [Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA.
RP Dingwell, JB (reprint author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
EM jdingwell@mail.utexas.edu
OI Wilken, Jason/0000-0002-5556-7667; Dingwell,
   Jonathan/0000-0001-6990-4153
FU Military Amputee Research Program; National Institutes of Health
   [1-R21-EB007638, 1-R01-HD059844]
FX Support provided by the Military Amputee Research Program (to JMW) and
   by National Institutes of Health Grants 1-R21-EB007638 and
   1-R01-HD059844 (to JBD).
NR 28
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U1 3
U2 23
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
J9 J BIOMECH
JI J. Biomech.
PD FEB 24
PY 2011
VL 44
IS 4
BP 644
EP 649
DI 10.1016/j.jbiomech.2010.11.007
PG 6
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA 738KQ
UT WOS:000288639100011
PM 21094944
ER

PT J
AU Picchioni, D
   Horovitz, SG
   Fukunaga, M
   Carr, WS
   Meltzer, JA
   Balkin, TJ
   Duyn, JH
   Braun, AR
AF Picchioni, Dante
   Horovitz, Silvina G.
   Fukunaga, Masaki
   Carr, Walter S.
   Meltzer, Jed A.
   Balkin, Thomas J.
   Duyn, Jeff H.
   Braun, Allen R.
TI Infraslow EEG oscillations organize large-scale cortical-subcortical
   interactions during sleep: A combined EEG/fMRI study
SO BRAIN RESEARCH
LA English
DT Article
DE Biological rhythms and sleep; Cortical oscillations; EEG; fMRI; Systems
   consolidation
ID SLOW-WAVE SLEEP; RESTING HUMAN BRAIN; FUNCTIONAL CONNECTIVITY; DEFAULT
   MODE; ALPHA-RHYTHM; SPINDLE ACTIVITY; POWER-DENSITY; FMRI; NETWORK; MRI
AB Infraslow (<0.1 Hz) oscillations of brain activity, measured by EEG and other methods, have become a subject of increasing interest. While their prominence during sleep has been established, the functional significance of these oscillations for sleep physiology is unknown. To clarify this role, we examined correlations between infraslow EEG oscillations and BOLD fMRI during the course of natural sleep in healthy volunteers. Infraslow EEG oscillations appear to organize a broad dissociation of activity in cortical and subcortical regions: in general, correlations between power in the infraslow EEG band and BOLD were positive in subcortical regions and negative in the cortex. Robust negative correlations were found principally in paramedian heteromodal cortices whereas positive correlations were seen in cerebellum, thalamus, basal ganglia, lateral neocortices and hippocampus. This pattern of correlations suggests a mechanism by which infraslow oscillations may organize sleep-dependent neuroplastic processes including consolidation of episodic memory. Published by Elsevier B.V.
C1 [Picchioni, Dante] Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA.
   [Horovitz, Silvina G.; Fukunaga, Masaki; Duyn, Jeff H.] Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD 20892 USA.
   [Carr, Walter S.; Meltzer, Jed A.; Braun, Allen R.] Natl Inst Deafness & Other Commun Disorders, NIH, Bethesda, MD 20892 USA.
RP Picchioni, D (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM dante.picchioni@amedd.army.mil
RI Fukunaga, Masaki/F-6441-2013; 
OI Fukunaga, Masaki/0000-0003-1010-2644; Meltzer, Jed/0000-0002-4301-1901
FU Intramural NIH HHS [Z99 DC999999]
NR 49
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U1 1
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD FEB 16
PY 2011
VL 1374
BP 63
EP 72
DI 10.1016/j.brainres.2010.12.035
PG 10
WC Neurosciences
SC Neurosciences & Neurology
GA 725DA
UT WOS:000287624200008
PM 21168395
ER

PT J
AU Clarisse, O
   Dimock, B
   Hintelmann, H
   Best, EPH
AF Clarisse, Olivier
   Dimock, Brian
   Hintelmann, Holger
   Best, Elly P. H.
TI Predicting Net Mercury Methylation in Sediments Using Diffusive Gradient
   in Thin Films Measurements
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID IN-SITU MEASUREMENTS; TRACE-METALS; LAVACA BAY; DGT; METHYLMERCURY;
   FLUXES; SPECIATION; PROFILES; ISOTOPES; WATERS
AB Diffusive gradient in thin film (DGT) sediment probes for methylmercury (MMHG) were successfully deployed for up to 30 h in three mudflat sediments in San Francisco Bay for measuring labile fractions of dissolved MMHg in pore water. Our calculations show that the local DGT-induced depletion of MMHg in sediment pore waters should be fully compensated by the natural in situ MMHg production and its subsequent remobilization from the solid phase. DGT results were interpreted in terms of labile pore water concentration and provide MATHg concentration depth profiles with a centimeter resolution. Average concentrations of DGT-labile MMEg were 2.10 +/- 0.29 and 1.64 +/- 0.30 ng L(-1) at China Camp and Hamilton Army Airfield sediment pore waters, respectively, while the riverine location at Petaluma showed a distinct peak of 7.1 ng L(-1) near the sediment surface. Using isotope-enriched mercury species, high resolution depth profiles of MMHg net production rates ranging from 0.2 to 9.8 ng g(-1) d(-1) were obtained in parallel sediment cores sampled closely to DGT deployment sites. A positive, linear relationship between MATHg net production rates and labile MMHg concentrations acquired through DGT measurements was found and explained 79% of the variability in the data set. The latter illustrates that mercury methylation, a biogeochemical process, strongly affected the quantity of MMEg accumulated by the DGT device in the sediment and suggests that DGT measurements have the potential to predict net methylation rates.
C1 [Clarisse, Olivier; Dimock, Brian; Hintelmann, Holger] Trent Univ, Dept Chem, Peterborough, ON K9J 7B8, Canada.
   [Clarisse, Olivier] Univ Moncton, Dept Chim & Biochim Moncton, Moncton, NB E1A 3E9, Canada.
   [Best, Elly P. H.] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
   [Best, Elly P. H.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
RP Clarisse, O (reprint author), Trent Univ, Dept Chem, 1600 W Bank Dr, Peterborough, ON K9J 7B8, Canada.
EM olivier.clarisse@umoncton.ca
OI Hintelmann, Holger/0000-0002-5287-483X
FU Long Term Management Strategy
FX This research was supported by the Long Term Management Strategy,
   administered by the U.S. Army Corps of Engineers (USACE) San Francisco
   District, awarded for the project 'Development of Diffusive Gradient in
   Thin Film (DGT) Sentinels for Monitoring Methylmercury (MMHg)
   Production' to H.H.
NR 29
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U1 3
U2 46
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD FEB 15
PY 2011
VL 45
IS 4
BP 1506
EP 1512
DI 10.1021/es102730n
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 718LI
UT WOS:000287122400050
PM 21222459
ER

PT J
AU Mohamed, AA
   Tan, SH
   Sun, C
   Shaheduzzaman, S
   Hu, Y
   Petrovics, G
   Chen, YM
   Sesterhenn, IA
   Li, H
   Sreenath, T
   McLeod, DG
   Dobi, A
   Srivastava, S
AF Mohamed, Ahmed A.
   Tan, Shyh-Han
   Sun, Chen
   Shaheduzzaman, Syed
   Hu, Ying
   Petrovics, Gyorgy
   Chen, Yongmei
   Sesterhenn, Isabell A.
   Li, Hua
   Sreenath, Taduru
   McLeod, David G.
   Dobi, Albert
   Srivastava, Shiv
TI ERG oncogene modulates prostaglandin signaling in prostate cancer cells
SO CANCER BIOLOGY & THERAPY
LA English
DT Article
DE prostate; cancer; ETS; ERG; TMPRSS2; oncogene; HPGD; tumor suppressor;
   prostaglandin; inflammation
ID NAD(+)-DEPENDENT 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE; TRANSCRIPTION
   FACTORS; TMPRSS2-ERG FUSION; COLORECTAL-CANCER; BREAST-CANCER; GENE
   FUSION; EXPRESSION; ETS; PROGRESSION; DIFFERENTIATION
AB Androgen dependent induction of the ETS related gene (ERG) expression in more than half of all prostate cancers results from gene fusions involving regulatory sequence of androgen regulated genes (i.e., TMPRSS2, SLC45A3 and NDRG1) and protein coding sequence of the ERG. Emerging studies in experimental models underscore the functions of ERG in prostate tumorigenesis. However, biological and biochemical functions of ERG in prostate cancer (CaP) remain to be elucidated. This study suggests that ERG activation plays a role in prostaglandin signaling because knockdown of ERG expression in TMPRSS2-ERG fusion containing CaP cells leads to altered levels of the 15-hydroxy-prostaglandin dehydrogenase (HPGD), a tumor suppressor and prostaglandin catabolizing enzyme and prostaglandin E(2) (PGE(2)). We demonstrate that HPGD expression is regulated by the binding of the ERG protein to the core promoter of this gene. Moreover, prostaglandin E(2) dependent cell growth and urokinase-type plasminogen activator (uPA) expression are also affected by ERG knockdown. Together, these data imply that the ERG oncoprotein in CaP cells positively influence prostaglandin mediated signaling, which may contribute to tumor progression.
C1 [Mohamed, Ahmed A.; Tan, Shyh-Han; Sun, Chen; Shaheduzzaman, Syed; Hu, Ying; Petrovics, Gyorgy; Chen, Yongmei; Li, Hua; Sreenath, Taduru; McLeod, David G.; Dobi, Albert; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD USA.
   [Sesterhenn, Isabell A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA.
   [Sesterhenn, Isabell A.; McLeod, David G.; Dobi, Albert; Srivastava, Shiv] US Mil Canc Inst, Washington, DC USA.
   [McLeod, David G.] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Urol Serv, Washington, DC 20307 USA.
RP Dobi, A (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD USA.
EM adobi@cpdr.org; ssrivastava@cpdr.org
RI Tan, Shyh-Han/I-7037-2013
OI Tan, Shyh-Han/0000-0001-8250-7005
FU US Army Medical Research and Material Command, NIH [RO1 DK065977]
FX This research was supported by the Center for Prostate Disease Research
   Program through an ongoing grant from the US Army Medical Research and
   Material Command, NIH Grant, RO1 DK065977 to Shiv Srivastava and Gyorgy
   Petrovics. The authors would like to thank Ms. Tia Morris for editing
   the manuscript and Mr. Stephen Doyle for graphics design. The views
   expressed in this manuscript are those of the authors and do not reflect
   the official policy of the Department of the Army, Department of Defense
   or the US Government. Released for publication by the WRAMC Public
   Affairs Office. The authors declare no competing financial interest.
NR 49
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U1 0
U2 2
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1538-4047
J9 CANCER BIOL THER
JI Cancer Biol. Ther.
PD FEB 15
PY 2011
VL 11
IS 4
BP 410
EP 417
DI 10.4161/cbt.11.4.14180
PG 8
WC Oncology
SC Oncology
GA 721MI
UT WOS:000287358500005
PM 21178489
ER

PT J
AU Hawley, JS
   Robottom, BJ
   Weiner, WJ
AF Hawley, Jason S.
   Robottom, Bradley J.
   Weiner, William J.
TI A Tale of Two Tauopathies
SO NEUROLOGY
LA English
DT Article
ID PROGRESSIVE SUPRANUCLEAR PALSY; CORTICOBASAL DEGENERATION; DIAGNOSIS;
   PSP
C1 [Robottom, Bradley J.; Weiner, William J.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Hawley, Jason S.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Robottom, BJ (reprint author), Univ Maryland, Sch Med, 110 S Paca St 3-S-128, Baltimore, MD 21201 USA.
EM brobottom@som.umaryland.edu
FU Chelsea Therapeutics; Solvay Pharmaceuticals, Inc./Abbott
   Pharmaceuticals; Novartis; Santhera Pharmaceuticals; Boehringer
   Ingelheim
FX Dr. Hawley is an active duty officer currently serving in the United
   States Army. Dr. Robottom receives research support from Chelsea
   Therapeutics and Solvay Pharmaceuticals, Inc./Abbott Pharmaceuticals.
   Dr. Weiner has served on scientific advisory boards for Santhera
   Pharmaceuticals and Rexahn Pharmaceuticals, Inc.; serves on the
   editorial boards of Parkinsonism and Related Disorders and Neurological
   Reviews, and as Editor of Treatment Options in Neurology; receives
   royalties from the publication of Neurology for the Non-Neurologist (6th
   edition, Kluwers/Lippincott, 2010), Parkinson's Disease: A Complete
   Guide for Patients and Family (2nd edition, Hopkins University Press,
   2007), and Handbook of Clinical Neurology Hyperkinetic Disorders
   (Elsevier, 2011); has received research support from Novartis, Santhera
   Pharmaceuticals, and 'Boehringer Ingelheim; and has provided expert
   testimony and served as a subject matter expert in legal proceedings.
NR 7
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U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0028-3878
J9 NEUROLOGY
JI Neurology
PD FEB 15
PY 2011
VL 76
IS 7
SU 2
BP S67
EP S68
DI 10.1212/WNL.0b013e31820d57d9
PG 2
WC Clinical Neurology
SC Neurosciences & Neurology
GA 721NT
UT WOS:000287362300013
PM 21321357
ER

PT J
AU Brantley, ST
   Zinnert, JC
   Young, DR
AF Brantley, Steven T.
   Zinnert, Julie C.
   Young, Donald R.
TI Application of hyperspectral vegetation indices to detect variations in
   high leaf area index temperate shrub thicket canopies
SO REMOTE SENSING OF ENVIRONMENT
LA English
DT Article
DE Canopy architecture; Canopy chlorophyll; Plant stress detection;
   Elaeagnus umbellata; Morella cerifera; Woody encroachment
ID NET PRIMARY PRODUCTION; LIGHT-USE EFFICIENCY; CHLOROPHYLL FLUORESCENCE;
   PHYSIOLOGICAL-RESPONSES; STRESS DETECTION; SALINITY STRESS;
   MYRICA-CERIFERA; MESIC GRASSLAND; DROUGHT STRESS; RED EDGE
AB Accurate measurement of leaf area index (LAI), an important characteristic of plant canopies directly linked to primary production, is essential for monitoring changes in ecosystem C stocks and other ecosystem level fluxes. Direct measurement of LAI is labor intensive, impractical at large scales and does not capture seasonal or annual variations in canopy biomass. The need to monitor canopy related fluxes across landscapes makes remote sensing an attractive technique for estimating LAI. Many vegetation indices, such as Normalized Difference Vegetation Index (NDVI), tend to saturate at LAI levels >4 although tropical and temperate forested ecosystems often exceed that threshold. Using two monospecific shrub thickets as model systems, we evaluated the potential of a variety of algorithms specifically developed to improve accuracy of LAI estimates in canopies where LAI exceeds saturation levels for other indices. We also tested the potential of indices developed to detect variations in canopy chlorophyll to estimate LAI because of the direct relationship between total canopy chlorophyll content and LAI. Indices were evaluated based on data from direct (litterfall) and indirect measurements (LAI-2000) of LAI. Relationships between results of direct and indirect ground-sampling techniques were also evaluated. For these two canopies, the indices that showed the highest potential to accurately differentiate LAI values >4 were derivative indices based on red-edge spectral reflectance. Algorithms intended to improve accuracy at high LAI values in agricultural systems were insensitive when LAI exceeded 4 and offered little or no improvement over NDVI. Furthermore, indirect ground-sampling techniques often used to evaluate the potential of vegetation indices also saturate when LAI exceeds 4. Comparisons between hyperspectral vegetation indices and a saturated LAI value from indirect measurement may overestimate accuracy and sensitivity of some vegetation indices in high LAI communities. We recommend verification of indirect measurements of LAI with direct destructive sampling or litterfall collection, particularly in canopies with high LAI. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Brantley, Steven T.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
   [Zinnert, Julie C.] USA, ERDC Fluorescence Spect Lab, Alexandria, VA 22315 USA.
RP Brantley, ST (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA.
EM brantleyst@vcu.edu
FU United States Army Research Office; NSF [DEB-008031]
FX This research was supported, in part, by a grant to Donald R. Young from
   the United States Army Research Office. Additional support was provided
   by NSF grant DEB-008031 to the University of Virginia for LTER-related
   work at the Virginia Coast Reserve. Spencer Bissett and Kati Rubis
   provided assistance with field work and laboratory analysis. The
   Virginia Coast Reserve LTER staff assisted with island logistics.
NR 53
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U1 3
U2 56
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0034-4257
J9 REMOTE SENS ENVIRON
JI Remote Sens. Environ.
PD FEB 15
PY 2011
VL 115
IS 2
BP 514
EP 523
DI 10.1016/j.rse.2010.09.020
PG 10
WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic
   Technology
SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science &
   Photographic Technology
GA 714BS
UT WOS:000286782500022
ER

PT J
AU Lin, JL
   Sproul, WD
   Moore, JJ
   Lee, S
   Myers, S
AF Lin, Jianliang
   Sproul, William D.
   Moore, John J.
   Lee, Sabrina
   Myers, Sterling
TI High rate deposition of thick CrN and Cr2N coatings using modulated
   pulse power (MPP) magnetron sputtering
SO SURFACE & COATINGS TECHNOLOGY
LA English
DT Article
DE Modulated pulse power (MPP); High power pulsed magnetron sputtering
   (HPPMS); High power impulse magnetron sputtering (HIPIMS); Thick
   coating; CrN coating; Cr2N coating; Wear
ID HARD COATINGS; NITRIDE FILMS; CHROMIUM; BEHAVIOR; SUBSTRATE; ADHESION;
   PLASMA; MICROSTRUCTURE; TEMPERATURE; TOUGHNESS
AB As a variation of high power pulsed magnetron sputtering technique, modulated pulse power (MPP) magnetron sputtering can achieve a high deposition rate while at the same time achieving a high degree of ionization of the sputtered material with low ion energies. These advantages of the MPP technique can be utilized to obtain dense coatings with a small incorporation of the residual stress and defect density for the thick coating growth. In this study, the MPP technique has been utilized to reactively deposit thick Cr2N and CrN coatings (up to 55 mu m) on AISI 440C steel and cemented carbide substrates in a closed field unbalanced magnetron sputtering system. High deposition rates of 15 and 10 mu m per hour have been measured for the Cr2N and CrN coating depositions, respectively, using a 3 kW average target power (16.7 W/cm(2) average target power density), a 50 mm substrate to target distance and an Ar/N-2 gas flow ratio of 3:1 and 1:1. The CrN coatings showed a denser microstructure than the Cr2N coatings, whereas the Cr2N coatings exhibited a smaller grain size and surface roughness than those of the CrN coatings for the same coating thickness. The compressive residual stresses in the CrN and Cr2N coatings increased as the coating thickness increased to 30 mu m and 20 mu m, respectively, but for thicker coatings, the stress gradually decreased as the coating thickness increased. The CrN coatings exhibited an increase in the scratch test critical load as the thickness was increased. Both CrN and Cr2N coatings showed a decrease in the hardness and an increase in the sliding coefficient of friction as the coating thickness increased from 2.5 to 55 mu m. However, the wear rate of the CrN coatings decreased significantly as the coating thickness was increased to 10 mu m or higher. The 10-55 mu m CrN coating exhibited low wear rates in the range of 3.5-5 x 10(-7) mm(3) N-1 m(-1). To the contrary, the Cr2N coating exhibited relatively low wear resistance in that high wear rates in the range of 3.5 to 7.5 x 10(-6) mm(3) N-1 m(-1) observed for different thicknesses. Published by Elsevier B.V.
C1 [Lin, Jianliang; Sproul, William D.; Moore, John J.; Myers, Sterling] Colorado Sch Mines, Dept Met & Mat Engn, ACSEL, Golden, CO 80401 USA.
   [Sproul, William D.] React Sputtering Inc, San Marcos, CA 92078 USA.
   [Lee, Sabrina] USA, ARDEC Benet Labs, Watervliet, NY 12189 USA.
RP Sproul, WD (reprint author), Colorado Sch Mines, Dept Met & Mat Engn, ACSEL, Golden, CO 80401 USA.
EM jlin@mines.edu; bsproul@cox.net
RI Lin, Jianliang/F-8405-2012
FU US Army
FX Support of this research program from the US Army is gratefully
   acknowledged. Dr. Zhili Wu at Dalian University of Technology, China, is
   acknowledged for help with the EPMA measurement.
NR 48
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U1 8
U2 57
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0257-8972
J9 SURF COAT TECH
JI Surf. Coat. Technol.
PD FEB 15
PY 2011
VL 205
IS 10
BP 3226
EP 3234
DI 10.1016/j.surfcoat.2010.11.039
PG 9
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA 715FQ
UT WOS:000286866400015
ER

PT J
AU Evans, RA
   Smith, WL
   Nguyen, NP
   Crouse, KL
   Crouse, CL
   Norman, SD
   Jakubowski, EM
AF Evans, Ronald A.
   Smith, Wendy L.
   Nguyen, Nam-Phuong
   Crouse, Kathy L.
   Crouse, Charles L.
   Norman, Steven D.
   Jakubowski, E. Michael
TI Quantification of VX Vapor in Ambient Air by Liquid Chromatography
   Isotope Dilution Tandem Mass Spectrometric Analysis of Glass Bead Filled
   Sampling Tubes
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID ACCIDENTAL EXPOSURE
AB An analysis method has been developed for determining low parts-per-quadrillion by volume (ppqv) concentrations of nerve agent VX vapor actively sampled from ambient air. The method utilizes glass bead filled depot area air monitoring system (DAAMS) sampling tubes with isopropyl alcohol extraction and isotope dilution using liquid chromatography coupled with a triple-quadrupole mass spectrometer (LC/MS/MS) with positive ion electrospray ionization for quantitation. The dynamic range was from one-tenth of the worker population limit (WPL) to the short-term exposure limit (STEL) for a 24 L air sample taken over a 1 h period. The precision and accuracy of the method were evaluated using liquid-spiked tubes, and the collection characteristics of the DAAMS tubes were assessed by collecting trace level vapor generated in a 1000 L continuous flow chamber. The method described here has significant improvements over currently employed thermal desorption techniques that utilize a silver fluoride pad during sampling to convert VX to a higher volatility G-analogue for gas chromatographic analysis. The benefits of this method are the ability to directly analyze VX with improved selectivity and sensitivity, the injection of a fraction of the extract, quantitation using an isotopically labeled internal standard, and a short instrument cycle time.
C1 [Evans, Ronald A.; Crouse, Kathy L.; Jakubowski, E. Michael] USA, Analyt Toxicol Branch, RDCB DRT T, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
   [Smith, Wendy L.; Nguyen, Nam-Phuong; Norman, Steven D.] USA, Environm Monitoring Branch, RDCB DPO M, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
   [Crouse, Charles L.] SAIC, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Evans, RA (reprint author), USA, Analyt Toxicol Branch, RDCB DRT T, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM ronald.a.evans@us.army.mil
FU U.S. Army Edgewood Chemical Biological Center Monitoring Branch; U.S.
   Army Edgewood Chemical Biological Center Analytical Toxicology Branch
FX The authors thank the U.S. Army Edgewood Chemical Biological Center
   Monitoring Branch and Analytical Toxicology Branch for supporting this
   project.
NR 14
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U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD FEB 15
PY 2011
VL 83
IS 4
BP 1315
EP 1320
DI 10.1021/ac1024683
PG 6
WC Chemistry, Analytical
SC Chemistry
GA 719CK
UT WOS:000287176900023
PM 21235231
ER

PT J
AU Zhang, LA
   Sathunuru, R
   Luong, T
   Melendez, V
   Kozar, MP
   Lin, AJ
AF Zhang, Liang
   Sathunuru, Ramadas
   Luong, ThuLan
   Melendez, Victor
   Kozar, Michael P.
   Lin, Ai J.
TI New imidazolidinedione derivatives as antimalarial agents
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Antimalarials; Imidazolidinedione; Preparation; Metabolic stability
ID PLASMODIUM-FALCIPARUM; INVITRO; DESIGN
AB A series of new N-alky- and N-alkoxy-imidazolidinediones was prepared and assessed for prophylactic and radical curative activities in mouse and Rhesus monkey models. New compounds are generally metabolically stable, weakly active in vitro against Plasmodium falciparum clones (D6 and W2) and in mice infected with Plasmodium berghei sporozoites. Representative compounds 8e and 9c showed good causal prophylactic activity in Rhesus monkeys dosed 30 mg/kg/day for 3 consecutive days by IM, delayed patency for 19-21 days and 54-86 days, respectively, as compared to the untreated control. By oral, 9c showed only marginal activity in causal prophylactic and radical curative tests at 50 mg/kg/day x 3 and 30 mg/kg/day x 7 plus chloroquine 10 mg/kg for 7 days, respectively. Published by Elsevier Ltd.
C1 [Zhang, Liang; Sathunuru, Ramadas; Luong, ThuLan; Melendez, Victor; Kozar, Michael P.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
EM ai.lin@us.army.mil
RI Kozar, Michael/A-9155-2011; Luong, Thu-Lan/A-9160-2011
FU Military Infections Diseases Research Program [A40191_09_WR]; Peer
   Reviewed Medical Research Program (PRMRP) [PR054609]; US Army Medical
   Research and Material Command, Department of Defense, USA.; Medicines
   for Malaria Venture, Geneva, Switzerland [MMV 04/0013]; National Science
   Foundation/Department of Energy [CHE-0535644]; US Department of Energy,
   Office of Science, Office of Basic Energy Sciences [DE-AC02-06CH11357]
FX Material has been reviewed by the Walter Reed Army Institute of
   Research. There is no objection to its presentation and/or publications.
   The opinions or assertions contained herein are the private views of the
   authors, and are not to be construed as official, or as reflecting true
   views of the Department of the Army or the Department of Defense. This
   research is supported in part by funding from Military Infections
   Diseases Research Program (A40191_09_WR), US Army Medical Research and
   Material Command, Department of Defense, USA., Peer Reviewed Medical
   Research Program (PRMRP) (Grant # PR054609), and Medicines for Malaria
   Venture (MMV 04/0013), Geneva, Switzerland. ChemMatCARS Sector 15 is
   principally supported by the National Science Foundation/Department of
   Energy under grant number CHE-0535644. Use of the Advanced Photon Source
   was supported by the US Department of Energy, Office of Science, Office
   of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357.
NR 16
TC 7
Z9 7
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD FEB 15
PY 2011
VL 19
IS 4
BP 1541
EP 1549
DI 10.1016/j.bmc.2010.12.028
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 724QU
UT WOS:000287592100021
PM 21282058
ER

PT J
AU Newburgh, GA
   Word-Daniels, A
   Michael, A
   Merkle, LD
   Ikesue, A
   Dubinskii, M
AF Newburgh, G. A.
   Word-Daniels, Akil
   Michael, Arocksiamy
   Merkle, Larry D.
   Ikesue, Akio
   Dubinskii, Mark
TI Resonantly diode-pumped Ho3+:Y2O3 ceramic 2.1 mu m laser
SO OPTICS EXPRESS
LA English
DT Article
ID HO-YAG LASER; Y2O3; IONS
AB We report what is believed to be the first laser operation based on Ho3(+)-doped Y2O3. The Ho3+:Y2O3 ceramic was resonantly diode-pumped at similar to 1.93 mu m to produce up to 2.5 W of continuous wave (CW) output power at similar to 2.12 mu m. The laser had a slope efficiency of similar to 35% with respect to absorbed power and a beam propagation factor of M-2 similar to 1.1. We have measured the absorption and stimulated emission cross sections of Ho3+:Y2O3 at 77 K and 300 K and present the calculated gain cross section spectrum at 77 K for different excited state inversion levels. (C) 2011 Optical Society of America
C1 [Newburgh, G. A.; Michael, Arocksiamy; Merkle, Larry D.; Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA.
   [Word-Daniels, Akil] Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA.
   [Ikesue, Akio] World Lab Co Ltd, Atsuta Ku, Nagoya, Aichi 4560023, Japan.
RP Newburgh, GA (reprint author), USA, Res Lab, RDRL SEE O 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM gnewburgh@arl.army.mil
FU High Energy Laser Joint Technology Office
FX This work was supported by the High Energy Laser Joint Technology
   Office.
NR 21
TC 32
Z9 32
U1 2
U2 32
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD FEB 14
PY 2011
VL 19
IS 4
BP 3604
EP 3611
DI 10.1364/OE.19.003604
PG 8
WC Optics
SC Optics
GA 741JM
UT WOS:000288860000080
PM 21369184
ER

PT J
AU Clark, DV
   Ismayilov, A
   Bakhishova, S
   Hajiyev, H
   Nuriyev, T
   Piraliyev, S
   Bagirov, S
   Aslanova, A
   Qasimov, M
   Hepburn, MJ
AF Clark, Danielle V.
   Ismayilov, Afrail
   Bakhishova, Sevinj
   Hajiyev, Huseyn
   Nuriyev, Tahir
   Piraliyev, Saleh
   Bagirov, Sadigulla
   Aslanova, Afag
   Qasimov, Maqsud
   Hepburn, Matthew J.
TI Under-utilization of health care services for infectious diseases
   syndromes in rural Azerbaijan: A cross-sectional study
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
ID DEPRESSION; PREVALENCE; STATES
AB Background: Infectious diseases present a potentially substantial yet undefined burden on the health of the adult Azerbaijani population. Efforts to quantify this burden in Azerbaijan are currently based almost exclusively on passive disease surveillance, and therefore hinge on the health utilization practices of the population. Understanding the prevalence of infectious syndromes and health utilization practices is paramount to disease surveillance, public health planning, and health care system reform.
   Methods: A two-stage, probability proportional to size sampling design was used to select a representative sample of three regions of northern Azerbaijan with village populations less than 500 people. Demographic, clinical, and epidemiologic parameters were assessed using prevalence odds ratios, chi-squared, and the Fisher exact test. Associations with p < 0.10 were included in the regression analysis and removed by backward elimination. Respondents included 796 adults from 39 villages.
   Results: Self-medication with antibiotics was the predominant utilization practice reported (19.4%). Only 1.3% of respondents reported seeing a health care provider for an infection, and 3.4% missed work or stayed in bed during the day in the last 5 years. In contrast, 338 illness episodes were reported in a 5 year period. Antibiotic use was significantly associated with gender, region, history of febrile illness, sleep disturbances, and arthritis controlling for age, ethnicity, and education. Influenza-like illness was the most prevalent infectious syndrome reported (33.3%).
   Conclusions: We observed a remarkably low utilization of health services, despite reported symptoms that would merit use. Widespread availability of antibiotics may deter health care use, and may contribute to the development of antibiotic resistance in this population. Information on utilization of health services during an infection is essential for development of effective intervention strategies, and data on the prevalence of infectious syndromes provides information not otherwise available in populations with low health care utilization.
C1 [Clark, Danielle V.] Walter Reed Army Inst Res, Silver Spring, MD USA.
   [Ismayilov, Afrail; Bakhishova, Sevinj; Hajiyev, Huseyn; Qasimov, Maqsud] Antiplague Stn, Baku, Azerbaijan.
   [Nuriyev, Tahir; Piraliyev, Saleh; Bagirov, Sadigulla] Ctr Hyg & Epidemiol, Baku, Azerbaijan.
   [Aslanova, Afag] Raytheon Tech Serv Co, Baku, Azerbaijan.
   [Hepburn, Matthew J.] USA, Res Inst Infect Dis, Ft Detrick, MD USA.
RP Clark, DV (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA.
EM dvclark@gmail.com
FU US Department of Defense
FX Funding for this project was provided by the US Department of Defense
   Cooperative Threat Reduction Program, implemented by the US Defense
   Threat Reduction Agency. The views expressed are those of the authors
   and should not be construed to represent the positions of the Department
   of the Army or Department of Defense. This information was presented in
   part at the American Society of Tropical Medicine and Hygiene annual
   meeting, Washington DC, USA, 19-22 November 2009.
NR 14
TC 5
Z9 5
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD FEB 11
PY 2011
VL 11
AR 32
DI 10.1186/1472-6963-11-32
PG 8
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA 730JL
UT WOS:000288029500001
PM 21314916
ER

PT J
AU Furey, J
   Morgan, C
AF Furey, John
   Morgan, Cliff
TI Quartic collimator design for high-energy gamma rays
SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS
   SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
LA English
DT Article
DE Gamma ray; Collimation; Quartic
ID PENETRATION
AB In a gamma ray detection system, the only rays that need to be shielded from a detector are those that could have entered unwanted. Gamma rays that could not have encountered the detector do not need shielding. This simple optimization principle leads to a quartic shape for a full aperture collimator of minimal volume for a generic detector. Both cylindrical and spherical cases are derived, and the results compare very favorably with other common configurations and collimator shapes, such as standard cylindrical apertures and parallel-hole masks. For one example of collimating 2.615 MeV gamma rays, a quartic collimator reduces the required volume by over 70% from a standard cylindrical collimator. Published by Elsevier B.V.
C1 [Furey, John; Morgan, Cliff] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Furey, J (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM john.s.furey@usace.army.mil
FU US Army Engineer Research and Development Center, Vicksburg, MS
FX This research was supported by the US Army Engineer Military Engineering
   Research Program at the US Army Engineer Research and Development
   Center, Vicksburg, MS.
NR 18
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-9002
J9 NUCL INSTRUM METH A
JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc.
   Equip.
PD FEB 11
PY 2011
VL 629
IS 1
BP 202
EP 205
DI 10.1016/j.nima.2010.10.075
PG 4
WC Instruments & Instrumentation; Nuclear Science & Technology; Physics,
   Nuclear; Physics, Particles & Fields
SC Instruments & Instrumentation; Nuclear Science & Technology; Physics
GA 724DK
UT WOS:000287556100032
ER

PT J
AU Balu, R
   Byrd, EFC
   Rice, BM
AF Balu, Radhakrishnan
   Byrd, Edward F. C.
   Rice, Betsy M.
TI Assessment of Dispersion Corrected Atom Centered Pseudopotentials:
   Application to Energetic Molecular Crystals
SO JOURNAL OF PHYSICAL CHEMISTRY B
LA English
DT Article
ID DENSITY-FUNCTIONAL-THEORY; INTERMOLECULAR FORCES; AB-INITIO; POTENTIALS;
   DIMERS; DFT; APPROXIMATIONS; APPLICABILITY; BIOMOLECULES; SYSTEMS
AB A comparative study of the structural features of molecular crystals 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX), cyclotrimethylenetrinitramine (RDX), 2,4,6-trinitro-1,3,5-benzenetriamine (TATB), and pentaerythritol tetranitrate (PETN) at ambient pressure were calculated using density functional theory (DFT) and dispersion corrected atom centered pseudopotentials (DCACPs). While the molecular structural parameters showed little dependence on the pseudopotential used, the overall volume and lattice vector lengths were substantially improved by the use of DCACPs. DCACP predictions of lattice vector lengths are within 1.3% of experiment, corresponding to an approximately 2% error in density. Conversely, DFT underestimates crystal densities by 5-10%. The results indicate that DCACPs substantially compensate for the inadequate description of van der Waals interaction:; in DFT. Additionally, comparison of DCACP predictions with analogous calculations using an alternate dispersion corrected DFT method indicate while both show an improvement over traditional DFT methods in describing van der Waals interactions for the molecular crystals in this study, the DCACP method is more accurate in predicting lattice vectors.
C1 [Balu, Radhakrishnan; Byrd, Edward F. C.; Rice, Betsy M.] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Byrd, EFC (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM edward.fc.byrd@us.army.mil
FU U.S. Department of Energy; USARL
FX Calculations were performed using the DOD Supercomputing Resource
   Centers (DSRCs) located at the U.S. Army Research Laboratory, the U.S.
   Army Engineer Research and Development Center, and the Air Force
   Research Laboratory. R.B. was supported by an appointment to the
   Internship/Research Participation Program for the U.S. Army Research
   Laboratory administered by the Oak Ridge Institute for Science and
   Education through an agreement between the U.S. Department of Energy and
   the USARL.
NR 62
TC 20
Z9 20
U1 2
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1520-6106
J9 J PHYS CHEM B
JI J. Phys. Chem. B
PD FEB 10
PY 2011
VL 115
IS 5
BP 803
EP 810
DI 10.1021/jp107760k
PG 8
WC Chemistry, Physical
SC Chemistry
GA 714HF
UT WOS:000286797700005
PM 21250728
ER

PT J
AU Arun, P
   Aleti, V
   Parikh, K
   Manne, V
   Chilukuri, N
AF Arun, Peethambaran
   Aleti, Vineela
   Parikh, Kalpana
   Manne, Veeraswamy
   Chilukuri, Nageswararao
TI Senescence Marker Protein 30 (SMP30) Expression in Eukaryotic Cells:
   Existence of Multiple Species and Membrane Localization
SO PLOS ONE
LA English
DT Article
ID REGUCALCIN TRANSGENIC RATS; EPITHELIAL NRK52E CELLS; HEP G2 CELLS;
   DIISOPROPYL PHOSPHOROFLUORIDATE; NUCLEAR-LOCALIZATION; ENDOGENOUS
   REGUCALCIN; OXIDATIVE STRESS; SOLUBLE FRACTION; LIVER NUCLEUS;
   PROTEOLYSIS
AB Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical warfare nerve agents. In our goal to investigate the activity of SMP30 for the detoxification of nerve agents, we have produced a recombinant adenovirus expressing human SMP30 as a fusion protein with a hemaglutinin tag (Ad-SMP30-HA). Ad-SMP30-HA transduced the expression of SMP30-HA and two additional forms of SMP30 with molecular sizes similar to 28 kDa and 24 kDa in HEK-293A and C3A liver cells in a dose and time-dependent manner. Intravenous administration of Ad-SMP30-HA in mice results in the expression of all the three forms of SMP30 in the liver and diaphragm. LC-MS/MS results confirmed that the lower molecular weight 28 kDa and 24 kDa proteins are related to the 34 kDa SMP30. The 28 kDa and 24 kDa SMP30 forms were also detected in normal rat liver and mice injected with Ad-SMP30-HA suggesting that SMP30 does exist in multiple forms under physiological conditions. Time course experiments in both cell lines suggest that the 28 kDa and 24 kDa SMP30 forms are likely generated from the 34 kDa SMP30. Interestingly, the 28 kDa and 24 kDa SMP30 forms appeared initially in the cytosol and shifted to the particulate fraction. Studies using small molecule inhibitors of proteolytic pathways revealed the potential involvement of beta and gamma-secretases but not calpains, lysosomal proteases, proteasome and caspases. This is the first report describing the existence of multiple forms of SMP30, their preferential distribution to membranes and their generation through proteolysis possibly mediated by secretase enzymes.
C1 [Arun, Peethambaran; Aleti, Vineela; Parikh, Kalpana; Manne, Veeraswamy; Chilukuri, Nageswararao] Walter Reed Army Inst Res, Dept Mol Pharmacol, Div Biochem, Silver Spring, MD 20910 USA.
RP Arun, P (reprint author), Walter Reed Army Inst Res, Dept Mol Pharmacol, Div Biochem, Silver Spring, MD 20910 USA.
EM nageswararao.chilukuri@us.army.mil
FU Defense Threat Reduction Agency (DTRA) [D0024_07_WR_C]
FX The work is supported by funds from Defense Threat Reduction Agency
   (DTRA, Project # D0024_07_WR_C). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 45
TC 13
Z9 13
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 9
PY 2011
VL 6
IS 2
AR e16545
DI 10.1371/journal.pone.0016545
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 721NN
UT WOS:000287361700020
PM 21347421
ER

PT J
AU Woo, HJ
   Wallqvist, A
AF Woo, Hyung-June
   Wallqvist, Anders
TI Nonequilibrium Phase Transitions Associated with DNA Replication
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID MODEL
AB Thermodynamics governing the synthesis of DNA and RNA strands under a template is considered analytically and applied to the population dynamics of competing replicators. We find a nonequilibrium phase transition for high values of polymerase fidelity in a single replicator, where the two phases correspond to stationary states with higher elongation velocity and lower error rate than the other. At the critical point, the susceptibility linking velocity to thermodynamic force diverges. The overall behavior closely resembles the liquid-vapor phase transition in equilibrium. For a population of self-replicating macromolecules, Eigen's error catastrophe transition precedes this thermodynamic phase transition during starvation. For a given thermodynamic force, the fitness of replicators increases with increasing polymerase fidelity above a threshold.
C1 [Woo, Hyung-June; Wallqvist, Anders] USA, Med Res & Mat Command, Biotechnol High Performance Comp Software Appl In, Telemed Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Woo, HJ (reprint author), USA, Med Res & Mat Command, Biotechnol High Performance Comp Software Appl In, Telemed Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM woo@bioanalysis.org
OI wallqvist, anders/0000-0002-9775-7469
FU Department of Defense High Performance Computing (HPC) Modernization
   Program Office under the HPC Software Applications Institute Initiative;
   U.S. Army Medical Research and Materiel Command
FX Funding support came from the Department of Defense High Performance
   Computing (HPC) Modernization Program Office under the HPC Software
   Applications Institute Initiative, the U.S. Army Medical Research and
   Materiel Command.
NR 21
TC 9
Z9 9
U1 0
U2 4
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD FEB 9
PY 2011
VL 106
IS 6
AR 060601
DI 10.1103/PhysRevLett.106.060601
PG 4
WC Physics, Multidisciplinary
SC Physics
GA 718OX
UT WOS:000287135400002
PM 21405451
ER

PT J
AU Gu, SH
   Kang, HJ
   Baek, LJ
   Noh, JY
   Kim, HC
   Klein, TA
   Yanagihara, R
   Song, JW
AF Gu, Se Hun
   Kang, Hae Ji
   Baek, Luck Ju
   Noh, Ji Yun
   Kim, Heung-Chul
   Klein, Terry A.
   Yanagihara, Richard
   Song, Jin-Won
TI Genetic diversity of Imjin virus in the Ussuri white-toothed shrew
   (Crocidura lasiura) in the Republic of Korea, 2004-2010
SO VIROLOGY JOURNAL
LA English
DT Article
ID FIRING POINTS 10; SMALL MAMMALS; GYEONGGI PROVINCE; UNITED-STATES; SCRUB
   TYPHUS; SIN-NOMBRE; HANTAVIRUS; LEPTOSPIROSIS; SURVEILLANCE; POPULATIONS
AB Recently, Imjin virus (MJNV), a genetically distinct hantavirus, was isolated from lung tissues of the Ussuri white toothed shrew (Crocidura lasiura) captured near the demilitarized zone in the Republic of Korea. To clarify the genetic diversity of MJNV, partial M-and L-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-MJNV IgG antibody-positive Ussuri white-toothed shrews captured between 2004 and 2010. A 531-nucleotide region of the M segment (coordinates 2,255 to 2,785) revealed that the 12 MJNV strains differed by 0-12.2% and 0-2.3% at the nucleotide and amino acid levels, respectively. A similar degree of nucleotide (0.2-11.9%) and amino acid (0-3.8%) difference was found in a 632-nucleotide length of the L segment (coordinates 962 to 1,593) of nine MJNV strains. Phylogenetic analyses, based on the partial M and L segments of MJNV strains generated by the neighbor-joining and maximum likelihood methods, showed geographic-specific clustering, akin to the phylogeography of rodent-borne hantaviruses.
C1 [Gu, Se Hun; Kang, Hae Ji; Baek, Luck Ju; Noh, Ji Yun; Song, Jin-Won] Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea.
   [Gu, Se Hun; Kang, Hae Ji; Baek, Luck Ju; Noh, Ji Yun; Song, Jin-Won] Korea Univ, Inst Viral Dis, Seoul 136705, South Korea.
   [Kang, Hae Ji; Yanagihara, Richard] Univ Hawaii Manoa, John A Burns Sch Med, Dept Pediat & Trop Med, Honolulu, HI 96813 USA.
   [Kang, Hae Ji; Yanagihara, Richard] Univ Hawaii Manoa, John A Burns Sch Med, Dept Med Microbiol, Honolulu, HI 96813 USA.
   [Kang, Hae Ji; Yanagihara, Richard] Univ Hawaii Manoa, John A Burns Sch Med, Dept Pharmacol, Honolulu, HI 96813 USA.
   [Kim, Heung-Chul; Klein, Terry A.] USA, MEDDAC Korea, APO, AP 96205 USA.
RP Song, JW (reprint author), Korea Univ, Coll Med, Dept Microbiol, 5-Ga Anam Dong, Seoul 136705, South Korea.
EM jwsong@korea.ac.kr
RI Valle, Ruben/A-7512-2013
FU National Institute of Allergy and Infectious Diseases [R01AI075057];
   National Center for Research Resources, National Institutes of Health
   [P2RR018727, G12RR003061]; U.S Department of Defense; Armed Forces
   Medical Intelligence Center (AFMIC)
FX This work was supported in part by U.S. Public Health Service grants
   from the National Institute of Allergy and Infectious Diseases
   (R01AI075057) and the National Center for Research Resources (P2RR018727
   and G12RR003061), National Institutes of Health, and grants from the U.S
   Department of Defense, Global Emerging Infectious Surveillance and
   Response System (GEIS), and the Armed Forces Medical Intelligence Center
   (AFMIC).
NR 24
TC 7
Z9 7
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD FEB 8
PY 2011
VL 8
AR 56
DI 10.1186/1743-422X-8-56
PG 6
WC Virology
SC Virology
GA 729SS
UT WOS:000287971800001
PM 21303516
ER

PT J
AU Deng, YP
   Meyer, SA
   Guan, X
   Escalon, BL
   Ai, JM
   Wilbanks, MS
   Welti, R
   Garcia-Reyero, N
   Perkins, EJ
AF Deng, Youping
   Meyer, Sharon A.
   Guan, Xin
   Escalon, Barbara Lynn
   Ai, Junmei
   Wilbanks, Mitchell S.
   Welti, Ruth
   Garcia-Reyero, Natalia
   Perkins, Edward J.
TI Analysis of Common and Specific Mechanisms of Liver Function Affected by
   Nitrotoluene Compounds
SO PLOS ONE
LA English
DT Article
ID BOBWHITE COLINUS-VIRGINIANUS; P-32 POSTLABELING ANALYSIS;
   DRUG-METABOLIZING-ENZYMES; OXIDATIVE DNA-DAMAGE; HEMOGLOBIN ADDUCTS;
   2,4,6-TRINITROTOLUENE TNT; PEROXISOME PROLIFERATOR; ACTIVATED RECEPTORS;
   LIPID-METABOLISM; BINDING-PROTEIN
AB Background: Nitrotoluenes are widely used chemical manufacturing and munitions applications. This group of chemicals has been shown to cause a range of effects from anemia and hypercholesterolemia to testicular atrophy. We have examined the molecular and functional effects of five different, but structurally related, nitrotoluenes on using an integrative systems biology approach to gain insight into common and disparate mechanisms underlying effects caused by these chemicals.
   Methodology/Principal Findings: Sprague-Dawley female rats were exposed via gavage to one of five concentrations of one of five nitrotoluenes [2,4,6-trinitrotoluene (TNT), 2-amino-4,6-dinitrotoluene (2ADNT) 4-amino-2,6-dinitrotoulene (4ADNT), 2,4-dinitrotoluene (2,4DNT) and 2,6-dinitrotoluene (2,6DNT)] with necropsy and tissue collection at 24 or 48 h. Gene expression profile results correlated well with clinical data and liver histopathology that lead to the concept that hematotoxicity was followed by hepatotoxicity. Overall, 2,4DNT, 2,6DNT and TNT had stronger effects than 2ADNT and 4ADNT. Common functional terms, gene expression patterns, pathways and networks were regulated across all nitrotoluenes. These pathways included NRF2-mediated oxidative stress response, aryl hydrocarbon receptor signaling, LPS/IL-1 mediated inhibition of RXR function, xenobiotic metabolism signaling and metabolism of xenobiotics by cytochrome P450. One biological process common to all compounds, lipid metabolism, was found to be impacted both at the transcriptional and lipid production level.
   Conclusions/Significance: A systems biology strategy was used to identify biochemical pathways affected by five nitroaromatic compounds and to integrate data that tie biochemical alterations to pathological changes. An integrative graphical network model was constructed by combining genomic, gene pathway, lipidomic, and physiological endpoint results to better understand mechanisms of liver toxicity and physiological endpoints affected by these compounds.
C1 [Deng, Youping] Rush Univ, Dept Internal Med, Ctr Canc, Med Ctr, Chicago, IL 60612 USA.
   [Meyer, Sharon A.] Univ Louisiana Monroe, Monroe, LA USA.
   [Guan, Xin] SpecProc Inc, Vicksburg, MS USA.
   [Escalon, Barbara Lynn; Wilbanks, Mitchell S.; Perkins, Edward J.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA.
   [Ai, Junmei] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39406 USA.
   [Welti, Ruth] Kansas State Univ, Div Biol Sci, Manhattan, KS 66506 USA.
   [Garcia-Reyero, Natalia] Jackson State Univ, Jackson, MS USA.
RP Deng, YP (reprint author), Rush Univ, Dept Internal Med, Ctr Canc, Med Ctr, Chicago, IL 60612 USA.
EM youping_deng@rush.edu
OI Welti, Ruth/0000-0003-4373-2538
FU US Army [W912HZ-05-P-0145]; SpecPro Inc.
FX This project was supported by US Army Environmental Quality Program
   (contract #W912HZ-05-P-0145) and SpecPro Inc. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
NR 76
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Z9 14
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 8
PY 2011
VL 6
IS 2
AR e14662
DI 10.1371/journal.pone.0014662
PG 26
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 717WH
UT WOS:000287077600001
PM 21346803
ER

PT J
AU Das, L
   Mateo, J
   Bandyopadhyay, S
   Bandyopadhyay, S
   Edwards, JD
   Anderson, J
AF Das, Lopamudra
   Mateo, Jennette
   Bandyopadhyay, Saumil
   Bandyopadhyay, Supriyo
   Edwards, Jarrod D.
   Anderson, John
TI Motional modes in bulk powder and few-molecule clusters of
   tris(8-hydroxyquinoline aluminum) and their relation to spin dephasing
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID FILMS
AB The ensemble averaged spin dephasing rate of localized electrons in the organic molecule tris(8-hydroxyquinoline aluminum) or Alq(3) has been found to be significantly larger in bulk powder than in single-or few-molecule clusters confined within 1-2 nm sized nanocavities [B. Kanchibotla et al., Phys. Rev. B 78, 193306 (2008)]. To understand this observation, we have compared the midinfrared absorption spectra of bulk powder and single-or few-molecule clusters. It appears that molecules have additional vibrational modes in bulk powder possibly due to multimerization. Their coupling with spin may be responsible for the increased spin dephasing rate in bulk powder. (C) 2011 American Institute of Physics. [doi:10.1063/1.3554753]
C1 [Das, Lopamudra; Mateo, Jennette; Bandyopadhyay, Saumil; Bandyopadhyay, Supriyo] Virginia Commonwealth Univ, Dept Elect & Comp Engn, Richmond, VA 23284 USA.
   [Edwards, Jarrod D.; Anderson, John] USA, Engn Res & Dev Ctr, Alexandria, VA 22315 USA.
RP Das, L (reprint author), Virginia Commonwealth Univ, Dept Elect & Comp Engn, Med Coll Virginia Campus, Richmond, VA 23284 USA.
EM sbandy@vcu.edu; sbandy@vcu.edu
NR 15
TC 2
Z9 2
U1 0
U2 6
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 0003-6951
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD FEB 7
PY 2011
VL 98
IS 6
AR 063109
DI 10.1063/1.3554753
PG 3
WC Physics, Applied
SC Physics
GA 719WL
UT WOS:000287242100050
ER

PT J
AU Yeh, IC
   Wallqvist, A
AF Yeh, In-Chul
   Wallqvist, Anders
TI On the proper calculation of electrostatic interactions in
   solid-supported bilayer systems
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; PERIODIC BOUNDARY-CONDITIONS; ATOMISTIC
   SIMULATIONS; HYDROPHILIC SURFACES; LIQUID WATER; INTERFACE; ADSORPTION;
   TRANSPORT; CHARMM; EWALD
AB Modeling systems that are not inherently isotropic, e. g., extended bilayers, using molecular simulation techniques poses a potential problem. Since these methods rely on a finite number of atoms and molecules to describe the system, periodic boundary conditions are implemented to avoid edge effects and capture long-range electrostatic interactions. Systems consisting of a solvated bilayer adsorbed on a solid surface and exposed to an air/vacuum interface occur in many experimental settings and present some unique challenges in this respect. Here, we investigated the effects of implementing different electrostatic boundary conditions on the structural and electrostatic properties of [quartz/water/vacuum interface and [similar quartz-supported hydrated lipid bilayer exposed to vacuum. Since these interfacial systems have [net polarization, implementing the standard Ewald summation with the conducting boundary condition for the electrostatic long-range interactions introduced an artificial periodicity in the out-of-plane dimension. In particular, abnormal orientational polarizations of water were observed with the conducting boundary condition. Implementing the Ewald summation technique with the planar vacuum boundary condition and calculating electrostatic properties compatible with the implemented electrostatic boundary condition removed these inconsistencies. This formulation is generally applicable to similar interfacial systems in bulk solution. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3548836]
C1 [Yeh, In-Chul; Wallqvist, Anders] USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Yeh, IC (reprint author), USA, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
EM icy@bioanalysis.org
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Assistant Secretary of the Army for Acquisition, Logistics,
   and Technology (ASAALT); Department of Defense (DoD) High Performance
   Computing (HPC) Modernization Program Office, under the HPC Software
   Applications Institute initiative; U.S. Army Medical Research and
   Materiel Command
FX We thank Dr. Ramanathan Nagarajan and Dr. Hyung-June Woo for their
   helpful suggestions and discussions. This project was funded in part by
   a competitive In-house Laboratory Independent Research (ILIR) grant by
   the U.S. Army Assistant Secretary of the Army for Acquisition,
   Logistics, and Technology (ASAALT). Funding support for this work also
   came from the Department of Defense (DoD) High Performance Computing
   (HPC) Modernization Program Office, under the HPC Software Applications
   Institute initiative, the U.S. Army Medical Research and Materiel
   Command. Computational time was provided by the U. S. Army Research
   Laboratory and Navy DoD Supercomputing Resource Centers. The opinions or
   assertions contained herein are the private views of the authors and are
   not to be construed as official or as reflecting the views of the U. S.
   Army or of the U. S. Department of Defense. This paper has been approved
   for public release.
NR 37
TC 10
Z9 10
U1 1
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 0021-9606
J9 J CHEM PHYS
JI J. Chem. Phys.
PD FEB 7
PY 2011
VL 134
IS 5
AR 055109
DI 10.1063/1.3548836
PG 9
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 718BT
UT WOS:000287095500085
PM 21303169
ER

PT J
AU McNutt, P
   Celver, J
   Hamilton, T
   Mesngon, M
AF McNutt, Patrick
   Celver, Jeremy
   Hamilton, Tracey
   Mesngon, Mariano
TI Embryonic stem cell-derived neurons are a novel, highly sensitive tissue
   culture platform for botulinum research
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Embryonic stem cells; Embryonic stem-cell-derived neurons; Botulinum
   neurotoxin; In vitro neurotoxicology
ID IN-VITRO; NEUROTOXIN; TOXIN; IDENTIFICATION; PERSISTENCE; ANTAGONISTS;
   GENERATION; RELEASE; ASSAY
AB There are no pharmacological treatments to rescue botulinum neurotoxin (BoNT)-mediated paralysis of neuromuscular signaling. In part, this failure can be attributed to the lack of a cell culture model system that is neuron-based, allowing detailed elucidation of the mechanisms underlying BoNT pathogenesis, yet still compatible with modern cellular and molecular approaches. We have developed a method to derive highly enriched, glutamatergic neurons from suspension-cultured murine embryonic stem (ES) cells. Hypothesizing that ES cell-derived neurons (ESNs) might comprise a novel platform to investigate the neurotoxicology of BoNTs, we evaluated the susceptibility of ESNs to BoNT/A and BoNT/E using molecular and functional assays. ESNs express neuron-specific proteins, develop synapses and release glutamate in a calcium-dependent manner under depolarizing conditions. They express the BoNT substrate SNARE proteins SNAP25, VAMP2 and syntaxin, and treatment with BoNT/A and BoNT/E holotoxin results in proteolysis of SNAP25 within 24 h with EC50s of 0.81 and 68.6 pM, respectively. Intoxication with BoNT/A results in the functional inhibition of potassium-induced, calcium-dependent glutamate release. ESNs remain viable and susceptible to intoxication for up to 90 days after plating, enabling longitudinal screens exploring toxin-specific mechanisms underlying persistence of synaptic blockade. The evidence suggests that derived neurons are a novel, biologically relevant model system that combines the verisimilitude of primary neurons with the genetic tractability and scalable expansion of a continuous cell line, and thus should significantly accelerate BoNT research and drug discovery while dramatically decreasing animal use. Published by Elsevier Inc.
C1 [McNutt, Patrick; Hamilton, Tracey; Mesngon, Mariano] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
   [Celver, Jeremy] Univ Rhode Isl, Kingston, RI 02881 USA.
RP McNutt, P (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM patrick.mcnutt@us.army.mil
OI McNutt, Patrick/0000-0002-5703-4565
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
   Medical ST Division [3.10037_08_RC_B]
FX We great appreciate the advice and support of Mike Adler, Jim Apland,
   Maya Leonetti (USAMRICD, MD) and Heidi Cederholm (Duke University, NC);
   and Dr. Joe Larson, Dr. Erin Reichert and the Defense Threat Reduction
   Agency-Joint Science and Technology Office, Medical S&T Division
   (proposal 3.10037_08_RC_B). The opinions, interpretations, conclusions,
   and recommendations are those of the author and are not necessarily
   endorsed by the U.S. Army or the Department of Defense.
NR 27
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U1 2
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD FEB 4
PY 2011
VL 405
IS 1
BP 85
EP 90
DI 10.1016/j.bbrc.2010.12.132
PG 6
WC Biochemistry & Molecular Biology; Biophysics
SC Biochemistry & Molecular Biology; Biophysics
GA 721EQ
UT WOS:000287336800016
PM 21215258
ER

PT J
AU Keiser, PB
   Biggs-Cicatelli, S
   Moran, EE
   Schmiel, DH
   Pinto, VB
   Burden, RE
   Miller, LB
   Moon, JE
   Bowden, RA
   Cummings, JF
   Zollinger, WD
AF Keiser, P. B.
   Biggs-Cicatelli, S.
   Moran, E. E.
   Schmiel, D. H.
   Pinto, V. B.
   Burden, R. E.
   Miller, L. B.
   Moon, J. E.
   Bowden, R. A.
   Cummings, J. F.
   Zollinger, W. D.
TI A phase 1 study of a meningococcal native outer membrane vesicle vaccine
   made from a group B strain with deleted lpxL1 and synX, over-expressed
   factor H binding protein, two PorAs and stabilized OpcA expression
SO VACCINE
LA English
DT Article
DE Vaccine; Neisseria meningitidis; NOMV; lpxL1; Lipopolysaccharide; LOS
ID NONTYPABLE HAEMOPHILUS-INFLUENZAE; NEISSERIA-MENINGITIDIS; BACTERICIDAL
   ACTIVITY; ANTIBODIES; IMMUNOGENICITY; INCREASES; ADJUVANT; MICE
AB This phase I clinical trial assessed the safety and immunogenicity of a native outer membrane vesicle (NOMV) vaccine prepared from an lpxL1(-)synX(-)mutant of strain 8570(B:4:P1.19,15:L8-5) of Neisseria meningitidis. Additional mutations enhance the expression of factor H binding protein variant 1 (fHbp v.1), stabilize expression of OpcA and introduce a second PorA (P1.22,14). Thirty-six volunteers were assigned to one of four dose groups (10, 25, 50 and 75 mcg, based on protein content) to receive three intramuscular injections at six week intervals with aluminum hydroxide adjuvant. Specific local and systemic adverse events were solicited by diary and at visits on days 2, 7, and 14 after each vaccination. Blood chemistries, complete blood count, and coagulation studies were measured on each vaccination day and again 2 and 14 days later. Blood for ELISA and serum bactericidal assays was drawn two and six weeks after each vaccination.
   The proportion of volunteers who developed a fourfold or greater increase in bactericidal activity to the wild type parent of the vaccine strain at two weeks after the third dose was 27 out of 34 (0.79, 95% C.I. 0.65-0.93). Against four other group B strains the response rate ranged from 41% to 82% indicating a good cross reactive antibody response. Depletion assays show contributions to bactericidal activity from antibodies to lipooligosaccharide (LOS), fHbp v.1 and OpcA. Published by Elsevier Ltd.
C1 [Keiser, P. B.; Biggs-Cicatelli, S.; Moran, E. E.; Schmiel, D. H.; Pinto, V. B.; Burden, R. E.; Miller, L. B.; Moon, J. E.; Bowden, R. A.; Cummings, J. F.; Zollinger, W. D.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Keiser, PB (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM paul.keiser@us.army.mil
RI Schmiel, Deborah/B-2875-2011; Moon, James/B-6810-2011
OI Moon, James/0000-0002-9274-4554
NR 33
TC 71
Z9 74
U1 2
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD FEB 4
PY 2011
VL 29
IS 7
BP 1413
EP 1420
DI 10.1016/j.vaccine.2010.12.039
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 727DJ
UT WOS:000287777500010
PM 21199704
ER

PT J
AU Palmer, JC
   Moore, JD
   Brennan, JK
   Gubbins, KE
AF Palmer, Jeremy C.
   Moore, Joshua D.
   Brennan, John K.
   Gubbins, Keith E.
TI Simulating Local Adsorption Isotherms in Structurally Complex Porous
   Materials: A Direct Assessment of the Slit Pore Model
SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS
LA English
DT Article
ID SIZE DISTRIBUTION ANALYSIS; DENSITY-FUNCTIONAL THEORY; MONTE-CARLO
   METHOD; ACTIVATED CARBON; PHASE-TRANSITIONS; GLASSES; METHANE
AB A fundamental understanding of the behaviour of fluids confined in structurally complex nanoporous materials is crucial to the development of improved technologies for environmental remediation and energy storage. We present a computational method for assessing the impact that confinement has on the properties of fluids in model porous materials. The proposed method is demonstrated by calculating pore size specific adsorption isotherms and adsorption selectivites in a structurally heterogeneous nanoporous carbo (NPC) model. The results from this method are used to test the predictions made by the ubiquitous slit pore (SP) model. In general, we find that the SP model does not qualitative capture the behaviour of the pore-size specific adsorption isotherms and selectivites in the NPC structure. These qualitative differences provide significant insight into the origins of the well-known deficiencies of the SP model to predict the adsorption behaviour of real NPCs.
C1 [Palmer, Jeremy C.; Gubbins, Keith E.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
   [Moore, Joshua D.; Brennan, John K.] USA, Weap & Mat Res Directorate, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Palmer, JC (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, 911 Partners Way, Raleigh, NC 27695 USA.
EM jcpalmer@ncsu.edu
FU U.S. Defense Threat Reduction Agency [AA07CBT011]; National Science
   Foundation [CBET-0932656, TG-CHE080046N]; U.S. Army Research Laboratory;
   U.S. Department of Energy; USARL [201003211]
FX We gratefully acknowledge support from the U.S. Defense Threat Reduction
   Agency (Project ID: AA07CBT011) and from the National Science Foundation
   (Grants CBET-0932656 and TG-CHE080046N). J.D.M. gratefully acknowledges
   support, in part, by an appointment to the Internship/Research
   Participation Program for the U.S. Army Research Laboratory administered
   by the Oak Ridge Institute for Science and Education through an
   agreement between the U.S. Department of Energy and USARL (Project ID:
   201003211).
NR 21
TC 10
Z9 10
U1 0
U2 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7185
J9 J PHYS CHEM LETT
JI J. Phys. Chem. Lett.
PD FEB 3
PY 2011
VL 2
IS 3
BP 165
EP 169
DI 10.1021/jz1015668
PG 5
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
   Multidisciplinary; Physics, Atomic, Molecular & Chemical
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 717LX
UT WOS:000287048800007
ER

PT J
AU Reddy, G
   Song, JA
   Kirby, P
   Lent, EM
   Crouse, LCB
   Johnson, MS
AF Reddy, Gunda
   Song, Jian
   Kirby, Paul
   Lent, Emily M.
   Crouse, Lee C. B.
   Johnson, Mark S.
TI Genotoxicity assessment of an energetic propellant compound, 3-nitro-1,2
   4-triazol-5-one (NTO)
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE 3-Nitro-1,2,4-triazol-5-one; CAS No. 932-64-9; Genotoxicity;
   Mutagenicity; Rat micronucleus; Flow cytometry
ID PERIPHERAL-BLOOD RETICULOCYTES; FLOW-CYTOMETRIC ANALYSIS; RAT-LIVER
   MICROSOMES; HAMSTER OVARY CELLS; C-14-LABELED
   5-NITRO-1,2,4-TRIAZOL-3-ONE; MUTAGENICITY TEST; MICRONUCLEI; CHEMICALS;
   VALIDATION; METABOLISM
AB 3-Nitro-1,2,4-triazol-5-one (NTO) is an energetic explosive proposed for use in weapon systems, to reduce the sensitivity of warheads. In order to develop toxicity data for safety assessment, we investigated the genotoxicity of NTO, using a battery of genotoxicity tests, which included the Ames test, Chinese Hamster Ovary (CHO) cell chromosome aberration test, L5178Y TK+/- mouse lymphoma mutagenesis test and rat micronucleus test. NTO was not mutagenic in the Ames test or in Escherichia coli (WP2uvrA). NTO did not induce chromosomal aberrations in CHO cells, with or without metabolic activation. In the L5178Y TK+/- mouse lymphoma mutagenesis test, all of the NTO-treated cultures had mutant frequencies that were similar to the average frequencies of solvent control-treated cultures, indicating a negative result. Confirmatory tests for the three in vitro tests also produced negative results. The potential in vivo clastogenicity and aneugenicity of NTO was evaluated using the rat peripheral blood micronucleus test. NTO was administered by oral gavage to male and female Sprague-Dawley rats for 14 days at doses up to 2 g/kg/day. Flow cytometric analysis of peripheral blood demonstrated no significant induction of micronucleated reticulocytes relative to the vehicle control (PEG-200). These studies reveal that NTO was not genotoxic in either in vitro or in vivo tests and suggest a low risk of genetic hazards associated with exposure. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Reddy, Gunda; Lent, Emily M.; Crouse, Lee C. B.; Johnson, Mark S.] USA, Publ Hlth Command, Aberdeen Proving Ground, MD 21005 USA.
   [Song, Jian; Kirby, Paul] SITEK Res Labs, Rockville, MD USA.
RP Reddy, G (reprint author), USA, Publ Hlth Command, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21005 USA.
EM gunda.reddy@us.army.mil
FU U.S. Army Research, Development and Engineering Command (RDECOM)
FX This work was funded by the U.S. Army Environmental Quality Technology
   (EQT) Ordnance Environmental Program (OEP) of the U.S. Army Research,
   Development and Engineering Command (RDECOM), Environmental Acquisition
   and Logistics Sustainment Program. We would like to thank Erick
   Hangeland and Chandrark Patel for their continued interest and support
   of this effort.
NR 39
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U1 1
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD FEB 3
PY 2011
VL 719
IS 1-2
BP 35
EP 40
DI 10.1016/j.mrgentox.2010.11.004
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 717NY
UT WOS:000287055900006
PM 21094274
ER

PT J
AU McFarland, CA
   Quinn, MJ
   Boyce, J
   LaFiandra, EM
   Bazar, MA
   Talent, LG
   Johnson, MS
AF McFarland, Craig A.
   Quinn, Michael J., Jr.
   Boyce, John
   LaFiandra, Emily M.
   Bazar, Matthew A.
   Talent, Larry G.
   Johnson, Mark S.
TI Toxic effects of oral 2-amino-4,6-dinitrotoluene in the Western fence
   lizard (Sceloporus occidentalis)
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Reptiles; Explosives; Amino-dinitrotoluene; Toxicity; Lizard
ID 2,4,6-TRINITROTOLUENE EXPOSURE; NITROAROMATIC COMPOUNDS;
   TRANSDIFFERENTIATION; SOIL; BIODEGRADATION; METABOLITES; DEGRADATION;
   FATE
AB The compound 2-amino-4,6-dinitrotoluene (2A-DNT) was evaluated under laboratory conditions in the Western fence lizard (Sceloporus occidentalis) to assess the potential for reptile toxicity. Oral LD(50) values were 1406 and 1867 mg/kg for male and female lizards, respectively. Based on responses from a 14-day subacute study, a 60-day subchronic experiment followed where lizards were orally dosed at 0, 5,15, 20, 25, 30 mg/kg-d. At day 60, number of days and survivors, food consumption, and change in body weight were inversely related to dose. Signs of toxicity were characterized by anorexia and generalized cachexia. Significant adverse histopathology was observed in hepatic tissue at >= 15 mg/kg-d, consistent with hepatocellular transdifferentiation. Based on survival, loss of body weight, diminished food intake, changes in liver, kidney, and testes, and increased blood urea nitrogen, these data suggest a LOAEL of 15 mg/kg-d and a NOAEL of 5 mg/kg-d in S. occidentalis. Published by Elsevier Ltd.
C1 [McFarland, Craig A.; Quinn, Michael J., Jr.; LaFiandra, Emily M.; Bazar, Matthew A.; Johnson, Mark S.] USA, Publ Hlth Command Prov, Aberdeen Proving Ground, MD 21010 USA.
   [Boyce, John] Biotechnics LLC, Hillsborough, NC 27278 USA.
   [Talent, Larry G.] Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA.
RP McFarland, CA (reprint author), USA, Publ Hlth Command Prov, Aberdeen Proving Ground, MD 21010 USA.
EM craig.a.mcfarland@us.army.mil
FU Strategic Environmental Research and Development Program (SERDP)
   [ER-1420]
FX We thank Dr's Guy Ampleman and Sonia Thiboutot of Valcartier, Canada for
   the synthesis of the parent compound used in the present study. We also
   thank Pat Beall, Robyn Lee, Dr. Gunda Reddy, and Dr. Rogely Waite Boyce
   for their advice and technical assistance during the course of this
   study. The funding for this work was provided through the Strategic
   Environmental Research and Development Program (SERDP ER-1420). The
   views expressed in this paper are those of the authors and do not
   reflect the official policy or position of the Department of Army.
   Department of Defense, or the U.S. Government. Mention of trade names or
   commercial products does not constitute endorsement or recommendation
   for use.
NR 36
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U1 1
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD FEB 2
PY 2011
VL 159
IS 2
BP 466
EP 473
DI 10.1016/j.envpol.2010.10.018
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA 716IT
UT WOS:000286963000016
PM 21067851
ER

PT J
AU Laubach, SS
   McKinney, K
AF Laubach, S. S.
   McKinney, K.
TI High Systemic Reaction Rate Using Cluster Build-up Schedule for
   Aeroallergen Immunotherapy
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Meeting Abstract
CT American-Academy-of-Allergy-Asthma-and-Immunology Annual Meeting
CY MAR 18-22, 2011
CL San Francisco, CA
SP Amer Acad Allergy Asthma & Immunol
C1 [Laubach, S. S.; McKinney, K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD FEB
PY 2011
VL 127
IS 2
SU S
BP AB49
EP AB49
DI 10.1016/j.jaci.2010.12.204
PG 1
WC Allergy; Immunology
SC Allergy; Immunology
GA 832YI
UT WOS:000295846400188
ER

PT J
AU Niebuhr, DW
   Krampf, RL
   Mayo, JA
   Blandford, CD
   Levin, LI
   Cowan, DN
AF Niebuhr, David W.
   Krampf, Rebekah L.
   Mayo, Jonathan A.
   Blandford, Caitlin D.
   Levin, Lynn I.
   Cowan, David N.
TI Risk Factors for Disability Retirement Among Healthy Adults Joining the
   U.S. Army
SO MILITARY MEDICINE
LA English
DT Article
ID MAXIMAL AEROBIC CAPACITY; PERSIAN-GULF-WAR; US-ARMY; AGE; MEN; INJURIES;
   EPIDEMIOLOGY; DISCHARGE; VETERANS; SOLDIERS
AB Objective: From 2001 10 2006, the Army deployed over 717,000 personnel to Iraq and Afghanistan, with over 15,000 troops wounded. Little is known about the impact of military and demographic factors, particularly deployment, occupation, and pre-existing medical status, on disability retirement. Methods: A nested case control study of first time, active duty personnel entering from 1997 to 2004. Cases, individuals granted a medical disability retirement from 1997 to 2006, were identified by the Army Physical Disability Agency. Five controls were matched by year of entrance to each case. Results: Several factors were associated with increased risk of disability retirement, including sex, age, Hispanic ethnicity, body mass index, and military occupation; deployment was associated with a lower risk. Conclusions: The reasons for increased risk among some groups are unknown. The decreased risk associated with deployment probably reflects a "healthy warrior effect," whereas the increased risk for combat arms may reflect combat exposures among the deployed and more rigorous training among the nondeployed.
C1 [Niebuhr, David W.; Krampf, Rebekah L.; Mayo, Jonathan A.; Blandford, Caitlin D.; Levin, Lynn I.; Cowan, David N.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA.
   [Mayo, Jonathan A.; Blandford, Caitlin D.; Cowan, David N.] Allied Technol Grp INC, Rockville, MD 20850 USA.
RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, 503 Robert Grant Rd, Silver Spring, MD 20910 USA.
FU US Army
FX The authors thank Ms Janice Gary of the Walter Reed Army Institute of
   Research, Department of Epidemiology, and Dr David Armitage (deceased),
   formerly of the Army Physical Disability Agency, for helpful review and
   comments. This research was funded by the US Army.
NR 29
TC 21
Z9 21
U1 2
U2 6
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2011
VL 176
IS 2
BP 170
EP 175
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BL
UT WOS:000295245800012
PM 21366079
ER

PT J
AU Patrick, V
   Critchfield, E
   Vaccaro, T
   Campbell, J
AF Patrick, Vijayalakshmy
   Critchfield, Edan
   Vaccaro, Thomas
   Campbell, Jason
TI The Relationship of Childhood Abuse and Early Separation From the
   Military Among Army Advanced Individual Trainees
SO MILITARY MEDICINE
LA English
DT Article
ID SEXUAL-ABUSE; US ARMY; ATTRITION; TRAUMA; DISORDERS; SOLDIERS; NAVY
AB Objective: To identify the prevalence rates and gender differences of childhood physical, sexual, and emotional abuse among advanced individual trainees and to determine if soldiers with a history of abuse increasingly separated from the Army before completing the training. Methods: Archival medical records of trainees presented to a military outpatient mental health clinic were analyzed for a history of abuse and separation from the Army. Results: A significant number of soldiers with a history of abuse were discharged from the Army without completing training. Females reported a higher prevalence of abuse than males; however, there was no significant relationship between gender and separation rates. The types of separations differed, with males more likely to be separated for conduct and females more often separated for medical reasons. Conclusion: Childhood abuse had a significant relationship on attrition rates among Army trainees and should be addressed to improve adaptation to the military.
C1 [Patrick, Vijayalakshmy; Critchfield, Edan; Campbell, Jason] Brooke Army Med Ctr, Dept Behav Med, Ft Sam Houston, TX 78234 USA.
   [Vaccaro, Thomas] Carl R Darnall Army Med Ctr, Resilience & Restorat Ctr, Ft Hood, TX 76544 USA.
RP Patrick, V (reprint author), Brooke Army Med Ctr, Dept Behav Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 15
TC 3
Z9 3
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2011
VL 176
IS 2
BP 182
EP 185
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BL
UT WOS:000295245800014
PM 21366081
ER

PT J
AU Funari, TS
   Gentzler, K
   Wyssling, PW
   Schoneboom, BA
AF Funari, Tamara S.
   Gentzler, Kevin
   Wyssling, Philip W.
   Schoneboom, Bruce A.
TI Building Adaptive Nurse Leaders for Future Army Full Spectrum Operations
SO MILITARY MEDICINE
LA English
DT Article
AB The Army Nurse Corps (ANC) life cycle model outlines major milestones that are required, expected, or recommended to be achieved to prepare Army Nurses to become senior leaders. Army nurses must be prepared to function in uncertain future full spectrum operational environment. The purpose of this study was to determine specific education and developmental experiences that will assist in developing ANC officers to become adaptive leaders through a review of literature and qualitative study. Fifteen interviews were conducted with senior ANC officers. Purposive sampling was used, yielding a sample population with a variety of experiences, to include deployments, recruiting, command, and joint operational assignments. Results indicated that the major themes for senior leader preparation are military education, field experience, and the need to add a new career pathway to ensure equal opportunity of advancement for both clinicians and administrators.
C1 [Funari, Tamara S.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
   [Gentzler, Kevin] Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS 66027 USA.
   [Wyssling, Philip W.] Command & Gen Staff Coll, Dept Logist & Resource Operat, Ft Leavenworth, KS 66027 USA.
   [Schoneboom, Bruce A.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA.
RP Funari, TS (reprint author), Brooke Army Med Ctr, 3851 Rodger Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 11
TC 0
Z9 1
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2011
VL 176
IS 2
BP 186
EP 191
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BL
UT WOS:000295245800015
PM 21366082
ER

PT J
AU Niven, AS
   Dezee, KJ
   Rinard, J
   Peterson, CK
   Roth, BJ
AF Niven, Alexander S.
   DeZee, Kent J.
   Rinard, John
   Peterson, Cecily K.
   Roth, Bernard J.
TI Impact of Practice Environment on Procedures Performed by U.S. Army
   General Internists
SO MILITARY MEDICINE
LA English
DT Article
ID MEDICINE
AB Background: A recent survey reported that U.S. general internists are performing fewer procedures, although practice environment heavily influences this experience. Objective: To determine the procedures performed by U.S. Army general internists. Design: Cross-sectional cohort study. Methods: A modified questionnaire was distributed to all active duty U.S. Army internists. Respondents were asked to indicate their practice setting and the procedures they had performed in the previous year. Analysis of variance, t-tests, and Fisher's exact test were used for statistical comparisons, and Bonferroni's correction was used for multiple comparisons. Results: Eighty-two internists responded to the survey (55% response rate). Army internists performed a greater variety of procedures than the civilian benchmark (10.8 vs. 6.5, p <0.001. t-test). Internists at Army community hospitals performed more types of procedures than individuals practicing in a tertiary care facility or troop clinic (13.8, 10.0, 9.0, respectively, p < 0.05, analysis of variance). Deployed internists performed more chest tube placements and endotracheal intubations, and internists at home were more likely to perform thoracentesis, paracentesis, graded exercise tests, and spirometry (p < 0.0012). Conclusions: U.S. Army internists perform a greater variety of procedures than their civilian colleagues. Our findings underline the importance of procedure training in military graduate and continuing medical education.
C1 [Niven, Alexander S.; Rinard, John; Peterson, Cecily K.; Roth, Bernard J.] Madigan Army Med Ctr, Dept Med, Tacoma, WA 98431 USA.
   [DeZee, Kent J.] Walter Reed Army Med Ctr, Dept Med, Gen Med Serv, Washington, DC 20507 USA.
RP Niven, AS (reprint author), Madigan Army Med Ctr, Dept Med, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA.
NR 7
TC 0
Z9 0
U1 0
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
J9 MIL MED
JI Milit. Med.
PD FEB
PY 2011
VL 176
IS 2
BP 192
EP 196
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA 825BL
UT WOS:000295245800016
PM 21366083
ER

PT J
AU Mohamed, A
   Sreenath, T
   Tan, SH
   Sun, C
   Shaheduzzaman, S
   Hu, Y
   Petrovics, G
   Chen, Y
   McLeod, D
   Dobi, A
   Srivastava, S
   Sesterhenn, I
AF Mohamed, A.
   Sreenath, T.
   Tan, S-H
   Sun, C.
   Shaheduzzaman, S.
   Hu, Y.
   Petrovics, G.
   Chen, Y.
   McLeod, D.
   Dobi, A.
   Srivastava, S.
   Sesterhenn, I.
TI ERG-Mediated Repression of HPGD in Prostate Tumorigenesis.
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the United States and
   Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP Canadian Acad Pathol
C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Rockville, MD USA.
   Armed Forces Inst Pathol, Washington, DC 20306 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2011
VL 91
SU 1
MA 893
BP 211A
EP 211A
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA 773CQ
UT WOS:000291285000333
ER

PT J
AU Russell, D
   Lee, GL
   Parker, P
   Furusato, B
   Young, DY
   Chen, Y
   Sreenath, T
   Dobi, A
   Mcleod, DG
   Srivastava, S
   Sesterhenn, IA
   Moncur, JT
AF Russell, D.
   Lee, G. L.
   Parker, P.
   Furusato, B.
   Young, D. Y.
   Chen, Y.
   Sreenath, T.
   Dobi, A.
   Mcleod, D. G.
   Srivastava, S.
   Sesterhenn, I. A.
   Moncur, J. T.
TI Diagnostic Value of ERG Oncoprotein Detection in Biopsy Specimens
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the United States and
   Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP Canadian Acad Pathol
C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Rockville, MD USA.
   Armed Forces Inst Pathol, Washington, DC 20306 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2011
VL 91
SU 1
MA 932
BP 221A
EP 221A
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA 773CQ
UT WOS:000291285000372
ER

PT J
AU Sesterhenn, IA
   Tan, SH
   Dobi, A
   Srivastava, S
   McLeod, DG
   Brassell, SA
   Furusato, B
AF Sesterhenn, I. A.
   Tan, S-H
   Dobi, A.
   Srivastava, S.
   McLeod, D. G.
   Brassell, S. A.
   Furusato, B.
TI Clinicopathological Correlation of ERG Protein Expression in Single
   Focus Prostate Cancer
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the United States and
   Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP Canadian Acad Pathol
C1 Armed Forces Inst Pathol, Washington, DC 20306 USA.
   Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2011
VL 91
SU 1
MA 941
BP 223A
EP 223A
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA 773CQ
UT WOS:000291285000381
ER

PT J
AU Keller, SD
AF Keller, Steven D.
TI Wire-Frame Monocone Antenna for Direction-Finding Applications on
   Unmanned Aerial Vehicle Platform
SO IEEE ANTENNAS AND PROPAGATION MAGAZINE
LA English
DT Article
DE Conical antennas; unmanned aerial vehicles; FEKO; simulation;
   electromagnetic measurements; wing; direction finding; blade antennas;
   monocone antennas
AB A detailed design for a loaded wire-frame monocone antenna for direction-finding applications on an Army UAV platform is presented. This was used to compare simulation and measurement results of radiation-pattern and gain measurements for a scaled prototype mounted on a UAV wing, using the FEKO electromagnetic-simulation software. The results indicated that this antenna design offers bandwidth and gain performance that is far superior to many other passive antenna candidates. The results also confirm the accuracy and efficiency of using FEKO for modeling candidate antennas integrated onto large-scale Army platforms.
C1 USA, Res Lab, RDRL SER M, Adelphi, MD 20783 USA.
RP Keller, SD (reprint author), USA, Res Lab, RDRL SER M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM steven.keller4@us.army.mil
NR 8
TC 1
Z9 1
U1 0
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1045-9243
EI 1558-4143
J9 IEEE ANTENN PROPAG M
JI IEEE Antennas Propag. Mag.
PD FEB
PY 2011
VL 53
IS 1
BP 56
EP 65
DI 10.1109/MAP.2011.5773568
PG 10
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 769WI
UT WOS:000291048600007
ER

PT J
AU Driscoll, JJ
   Minter, A
   Driscoll, DA
   Burris, JK
AF Driscoll, James J.
   Minter, Alex
   Driscoll, Daniel A.
   Burris, Jason K.
TI The Ubiquitin plus Proteasome Protein Degradation Pathway as a
   Therapeutic Strategy in the Treatment of Solid Tumor Malignancies
SO ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
LA English
DT Article
DE Ubiquitin; Proteasome; Bortezomib; Solid Tumors
ID KINASE INHIBITOR P27; MULTIPLE-MYELOMA CELLS; CANCER-THERAPY;
   PI3K/AKT/MTOR PATHWAY; MOLECULAR-BASIS; LUNG-CANCER; KAPPA-B;
   BORTEZOMIB; RESISTANCE; TARGET
AB A concept that currently steers the development of cancer therapies has been that agents directed against specific proteins that facilitate tumorigenesis or maintain a malignant phenotype will have greater efficacy, less toxicity and a more sustained response relative to traditional cytotoxic chemotherapeutic agents. The clinical success of the targeted agent Imatinib mesylate as an inhibitor of the tyrosine kinase associated with the breakpoint cluster region-Abelson oncogene locus (BCR-ABL) in the treatment of Philadelphia-positive chronic myelogenous leukemia (CML) has served as a paradigm. While intellectually gratifying, the selective targeting of a single driver event by a small molecule, e. g., kinase inhibitor, to dampen a tumor-promoting pathway in the treatment of solid tumors is limited by many factors. Focus can alternatively be placed on targeting fundamental cellular processes that regulate multiple events, e. g., protein degradation, through the Ubiquitin (Ub)+Proteasome System (UPS). The UPS plays a critical role in modulating numerous cellular proteins to regulate cellular processes such as signal transduction, growth, proliferation, differentiation and apoptosis. Clinical success with the proteasome inhibitor bortezomib revolutionized treatment of B-cell lineage malignancies such as Multiple Myeloma (MM). However, many patients harbor primary resistance and do not respond to bortezomib and those that do respond inevitably develop resistance (secondary resistance). The lack of clinical efficacy of proteasome inhibitors in the treatment of solid tumors may be linked mechanistically to the resistance detected during treatment of hematologic malignancies. Potential mechanisms of resistance and means to improve the response to proteasome inhibitors in solid tumors are discussed.
C1 [Driscoll, James J.; Minter, Alex; Burris, Jason K.] NCI, Med Oncol Branch, Magnuson Canc Ctr, NIH, Bethesda, MD 20892 USA.
   [Minter, Alex; Burris, Jason K.] Walter Reed Army Med Ctr, Dept Med, Hematol Oncol Serv, Washington, DC 20307 USA.
   [Driscoll, Daniel A.] Harvard Univ, Cambridge, MA 02138 USA.
RP Driscoll, JJ (reprint author), NCI, Med Oncol Branch, Magnuson Canc Ctr, NIH, 10 Ctr Dr,12N-226, Bethesda, MD 20892 USA.
EM driscollj@mail.nih.gov
NR 61
TC 13
Z9 15
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5206
J9 ANTI-CANCER AGENT ME
JI Anti-Cancer Agents Med. Chem.
PD FEB
PY 2011
VL 11
IS 2
BP 242
EP 246
PG 5
WC Oncology; Chemistry, Medicinal
SC Oncology; Pharmacology & Pharmacy
GA 764EY
UT WOS:000290613000010
PM 21355840
ER

PT J
AU Eichhorn, JH
   Crothers, BA
   Wilbur, DC
AF Eichhorn, J. H.
   Crothers, B. A.
   Wilbur, D. C.
TI Gynecologic Telecytology Using Automated Local Image Selection with
   Remote Interpretation: The Results of a Phase 2 Prospective Trial
SO MODERN PATHOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting United States-and-Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP United States Canadian Acad Pathol
C1 Massachusetts Gen Hosp, Boston, MA 02114 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0893-3952
J9 MODERN PATHOL
JI Mod. Pathol.
PD FEB
PY 2011
VL 24
SU 1
MA 364
BP 89A
EP 89A
PG 1
WC Pathology
SC Pathology
GA 720LN
UT WOS:000287282300366
ER

PT J
AU Mohamed, A
   Sreenath, T
   Tan, SH
   Sun, C
   Shaheduzzaman, S
   Hu, Y
   Petrovics, C
   Chen, Y
   McLeod, D
   Dobi, A
   Srivastava, S
   Sesterhenn, I
AF Mohamed, A.
   Sreenath, T.
   Tan, S-H
   Sun, C.
   Shaheduzzaman, S.
   Hu, Y.
   Petrovics, C.
   Chen, Y.
   McLeod, D.
   Dobi, A.
   Srivastava, S.
   Sesterhenn, I.
TI ERG-Mediated Repression of HPGD in Prostate Tumorigenesis
SO MODERN PATHOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting United States-and-Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP United States Canadian Acad Pathol
C1 Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Rockville, MD USA.
   Armed Forces Inst Pathol, Washington, DC 20306 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0893-3952
J9 MODERN PATHOL
JI Mod. Pathol.
PD FEB
PY 2011
VL 24
SU 1
MA 893
BP 211A
EP 211A
PG 1
WC Pathology
SC Pathology
GA 720LN
UT WOS:000287282301048
ER

PT J
AU Russell, D
   Lee, GL
   Parker, P
   Furusato, B
   Young, DY
   Chen, Y
   Sreenath, T
   Dobi, A
   Mcleod, DG
   Srivastava, S
   Sesterhenn, IA
   Moncur, JT
AF Russell, D.
   Lee, G. L.
   Parker, P.
   Furusato, B.
   Young, D. Y.
   Chen, Y.
   Sreenath, T.
   Dobi, A.
   Mcleod, D. G.
   Srivastava, S.
   Sesterhenn, I. A.
   Moncur, J. T.
TI Diagnostic Value of ERG Oncoprotein Detection in Biopsy Specimens
SO MODERN PATHOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting United States-and-Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP United States Canadian Acad Pathol
C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Rockville, MD USA.
   Armed Forces Inst Pathol, Washington, DC 20306 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0893-3952
J9 MODERN PATHOL
JI Mod. Pathol.
PD FEB
PY 2011
VL 24
SU 1
MA 932
BP 221A
EP 221A
PG 1
WC Pathology
SC Pathology
GA 720LN
UT WOS:000287282301087
ER

PT J
AU Sesterhenn, IA
   Tan, SH
   Dobi, A
   Srivastava, S
   McLeod, DG
   Brassell, SA
   Furusato, B
AF Sesterhenn, I. A.
   Tan, S-H
   Dobi, A.
   Srivastava, S.
   McLeod, D. G.
   Brassell, S. A.
   Furusato, B.
TI Clinicopathological Correlation of ERG Protein Expression in Single
   Focus Prostate Cancer
SO MODERN PATHOLOGY
LA English
DT Meeting Abstract
CT 100th Annual Meeting United States-and-Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP United States Canadian Acad Pathol
C1 Armed Forces Inst Pathol, Washington, DC 20306 USA.
   Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0893-3952
J9 MODERN PATHOL
JI Mod. Pathol.
PD FEB
PY 2011
VL 24
SU 1
MA 941
BP 223A
EP 223A
PG 1
WC Pathology
SC Pathology
GA 720LN
UT WOS:000287282301096
ER

PT J
AU Scott, BA
   Barnes, CM
AF Scott, Brent A.
   Barnes, Christopher M.
TI A MULTILEVEL FIELD INVESTIGATION OF EMOTIONAL LABOR, AFFECT, WORK
   WITHDRAWAL, AND GENDER
SO ACADEMY OF MANAGEMENT JOURNAL
LA English
DT Article
ID SELF-REGULATION; MODERATING ROLE; SEX-DIFFERENCES; EXPERIENCE; SERVICE;
   CONSEQUENCES; EXPRESSION; JOB; MODEL; MEDIATION
AB Using experience-sampling methodology, we examined within-individual relationships among emotional labor, negative and positive affective states, and work withdrawal, as well as the moderating role of gender. Fifty-eight bus drivers completed two daily surveys over a two-week period, producing 415 matched surveys. Results of hierarchical linear models revealed that affective states worsened when employees engaged in surface acting but improved when they engaged in deep acting. Surface acting was positively associated with work withdrawal, and state negative affect mediated this relationship. Results also revealed moderating effects of gender: the within-individual relationships were stronger for females than for males.
C1 [Scott, Brent A.] Michigan State Univ, Eli Broad Coll Business, E Lansing, MI 48824 USA.
   [Barnes, Christopher M.] US Mil Acad, Ctr Army Profess & Eth, West Point, NY USA.
RP Scott, BA (reprint author), Michigan State Univ, Eli Broad Coll Business, E Lansing, MI 48824 USA.
EM scott@bus.msu.edu; christopher.barnes@usma.edu
RI Barnes, Christopher/O-4814-2014
OI Barnes, Christopher/0000-0003-2520-6200
NR 80
TC 71
Z9 72
U1 12
U2 79
PU ACAD MANAGEMENT
PI BRIARCLIFF MANOR
PA PACE UNIV, PO BOX 3020, 235 ELM RD, BRIARCLIFF MANOR, NY 10510-8020 USA
SN 0001-4273
EI 1948-0989
J9 ACAD MANAGE J
JI Acad. Manage. J.
PD FEB
PY 2011
VL 54
IS 1
BP 116
EP 136
PG 21
WC Business; Management
SC Business & Economics
GA 743LR
UT WOS:000289020300006
ER

PT J
AU Valente, JJ
   King, SL
   Wilson, RR
AF Valente, Jonathon J.
   King, Sammy L.
   Wilson, R. Randy
TI Distribution and Habitat Associations of Breeding Secretive Marsh Birds
   in Louisiana's Mississippi Alluvial Valley
SO WETLANDS
LA English
DT Article
DE Bittern; Rail; Wetland
ID SITE-OCCUPANCY; SOUTHWESTERN LOUISIANA; COMMON MOORHEN; YELLOW RAILS;
   KING RAILS; NEW-YORK; RIVER; CONSERVATION; WATERBIRDS; ABUNDANCE
AB Populations of many North American secretive marsh birds (SMBs) have declined in recent decades, partially as a function of wetland loss. Protecting and restoring appropriate habitat for these species is contingent upon understanding the habitat features they utilize. We investigated breeding distributions of SMBs in northeast Louisiana at 118 wetlands in 2007 and 2008 and modeled species occupancy (psi) as a function of habitat variables measured at local (<= 100 m) and landscape (<= 1 km) scales. Common Moorhens (Gallinula chloropus), Least Bitterns (Ixobrychus exilis), and Purple Gallinules (Porphyrula martinica) were the most commonly detected species, whereas breeding King Rails (Rallus elegans) and American Coots (Fulica americana) were rare. Local habitat features consistently played a greater role in predicting psi than landscape features for the three most common species. The proportion of local wetland area dominated by robust emergent vegetation (i.e., Typha spp. and Zizaniopsis miliacea) positively influenced psi for all species, while other wetland vegetation types tended to have a minimal or negative effect. Our results suggest the habitat characteristics preferred by breeding SMBs differ from those used by migrating shorebirds and wintering waterfowl and management and restoration objectives for those species may be inadequate for enhancing SMB habitat.
C1 [Valente, Jonathon J.] Louisiana State Univ, Sch Renewable Nat Resources, Baton Rouge, LA 70803 USA.
   [King, Sammy L.] Louisiana State Univ, US Geol Survey, Louisiana Cooperat Fish & Wildlife Res Unit, Sch Renewable Nat Resources 124, Baton Rouge, LA 70803 USA.
   [Wilson, R. Randy] US Fish & Wildlife Serv, Jackson, MS 39213 USA.
RP Valente, JJ (reprint author), USA, Environm Lab, Engn Res & Dev Ctr, Louisville, KY 40204 USA.
EM Jonathon.J.Valente@gmail.com
FU U.S. Fish & Wildlife Service State Wildlife [T-41-R]
FX This project was funded by U.S. Fish & Wildlife Service State Wildlife
   Grant T-41-R which was administered by the Louisiana Department of
   Wildlife and Fisheries. The use of trade, product, or industry firm
   names or products is for informative purposes only and does not
   constitute an endorsement by the U.S. Government or the U.S. Geological
   Survey. We thank J. A. Nyman, P. Stouffer, K. McCarter, B. Strader, M.
   Kaller, S. Pierluissi, T. Cooper and the late R. Helm for their
   intellectual contributions. We also thank C. Duplechain, D. Crawford, E.
   DeLeon, T. Gancos, E. Hunter, J. Unger, J. Keiser, M. Osinskie, J.
   Russell, R. Villani, H. Gee, B. Pickens, P. Newell, S. R. Kang, for
   their logistical assistance. Lastly, this research would not have been
   possible without the support and resources provided by numerous
   individuals working for the Louisiana Department of Wildlife and
   Fisheries, U.S. Fish and Wildlife Service, and Natural Resources
   Conservation Service.
NR 51
TC 9
Z9 10
U1 5
U2 33
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0277-5212
EI 1943-6246
J9 WETLANDS
JI Wetlands
PD FEB
PY 2011
VL 31
IS 1
BP 1
EP 10
DI 10.1007/s13157-010-0138-3
PG 10
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA 741ZO
UT WOS:000288907700001
ER

PT J
AU Clifton, GT
   Sears, AK
   Clive, KS
   Holmes, JP
   Mittendorf, EA
   Ioannides, CG
   Ponniah, S
   Peoples, GE
AF Clifton, Guy T.
   Sears, Alan K.
   Clive, Kevin S.
   Holmes, Jarrod P.
   Mittendorf, Elizabeth A.
   Ioannides, Constantine G.
   Ponniah, Sathibalan
   Peoples, George E.
TI Folate receptor alpha A storied past and promising future in
   immunotherapy
SO HUMAN VACCINES
LA English
DT Review
DE folate receptor alpha; folate binding protein; immunotherapy
ID MONOCLONAL-ANTIBODY MOV18; CYTOTOXIC T-LYMPHOCYTE; CARCINOMA-ASSOCIATED
   ANTIGENS; OVARIAN-CANCER PATIENTS; BINDING-PROTEIN; TUMOR-CELLS;
   ANTITUMOR-ACTIVITY; DENDRITIC CELLS; BREAST-CANCER; PHASE-I
AB Folate receptor alpha (FR alpha) is a membrane-bound transport protein with several features which make it an attractive target for cancer immunotherapy. FR alpha is largely shielded from the immune system in normal tissue but exposed while expressed on a variety of malignancies; it is functionally active in cancer pathogenesis; and it is immunogenic. A variety of different immunotherapeutic methods targeting FR alpha are being explored to treat cancer. Passive immunotherapy includes monoclonal antibodies, antibodies modified to deliver treatments and modified T cell therapy. Active immunotherapy has focused on using FR alpha to increase the immunogenicity of cancer or to generate active FR alpha-directed immunity through a range of vaccination techniques. We will review the rationale behind targeting immunotherapy to FR alpha and cover the various techniques designed to do this.
   Folate Receptor alpha (FR alpha) is a unique tumor-associated antigen (TAA) with many characteristics that make it an attractive target for immunotherapy in cancer. Many different immunotherapeutic modalities utilizing FR alpha are being explored to treat cancer. The research is in various stages: some are just beyond conception, others have been tried and abandoned, and others still are progressing through human clinical trials. This review will cover immunotherapeutic methods, both active and passive, that target FR alpha.
C1 [Clifton, Guy T.; Sears, Alan K.; Clive, Kevin S.; Peoples, George E.] Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, Ft Sam Houston, TX 78234 USA.
   [Holmes, Jarrod P.] USN, Dept Med, Div Hematol & Med Oncol, San Diego Med Ctr, San Diego, CA 92152 USA.
   [Ioannides, Constantine G.] UTMD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX USA.
   [Mittendorf, Elizabeth A.] UTMD Anderson Canc Ctr, Dept Surg, Houston, TX USA.
   [Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD 20814 USA.
RP Peoples, GE (reprint author), Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, Ft Sam Houston, TX 78234 USA.
EM george.peoples@us.army.mil
NR 89
TC 8
Z9 9
U1 1
U2 6
PU LANDES BIOSCIENCE
PI AUSTIN
PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA
SN 1554-8600
J9 HUM VACCINES
JI Hum. Vaccines
PD FEB
PY 2011
VL 7
IS 2
BP 183
EP 190
DI 10.4161/hv.7.2.13784
PG 8
WC Biotechnology & Applied Microbiology; Immunology
SC Biotechnology & Applied Microbiology; Immunology
GA 743BQ
UT WOS:000288990900007
PM 21321484
ER

PT J
AU Terrio, HP
   Nelson, LA
   Betthauser, LM
   Harwood, JE
   Brenner, LA
AF Terrio, Heidi P.
   Nelson, Lonnie A.
   Betthauser, Lisa M.
   Harwood, Jeri E.
   Brenner, Lisa A.
TI Postdeployment Traumatic Brain Injury Screening Questions: Sensitivity,
   Specificity, and Predictive Values in Returning Soldiers
SO REHABILITATION PSYCHOLOGY
LA English
DT Article
DE concussion; military; postdeployment; screening; traumatic brain injury
ID POSTTRAUMATIC-STRESS-DISORDER; IRAQ; IDENTIFICATION; RELIABILITY;
   AFGHANISTAN; POPULATION; DEPRESSION; DEPLOYMENT; SYMPTOMS; VALIDITY
AB Objective: To evaluate the sensitivity, specificity, and predictive values of Post-Deployment Health Assessment traumatic brain injury (TBI) screening questions employed by the Department of Defense (DOD). Participants: Complete data was obtained from 3,072 soldiers upon return from a 15-month deployment to Iraq. Method: Comparisons were made between responses to the DOD four-item screener and a brief structured clinical interview for likely deployment-related TBI history. The interview process was facilitated using responses to the Warrior Administered Retrospective Casualty Assessment Tool (WARCAT). Results: The sensitivity and specificity of the DOD screening tool (positive response to all four items) in comparison to the clinician-confirmed diagnosis was 60% and 96%, respectively. The sensitivity increased to 80%, with a slight decrease in specificity to 93%, for positive TBI screening when affirmative responses to questions 1 and 2 only were included. Conclusions: Affirmative responses to questions 1 and 2 of the DOD TBI screening tool demonstrated higher sensitivity for clinician-diagnosed deployment-related TBI. These two items perform better than positive responses to all four questions; the criteria presently being used for documentation and referral of a deployment-related TBI. These findings support further exploration of TBI screening and assessment procedures.
C1 [Terrio, Heidi P.] Evans Army Community Hosp, Def & Vet Brain Injury Ctr, Dept Deployment Hlth, Ft Carson, CO USA.
   [Betthauser, Lisa M.] Univ Colorado Denver, Mental Illness Res Educ & Clin Ctr, Denver VA Med Ctr, Denver, CO USA.
   [Harwood, Jeri E.] Univ Colorado Denver, Dept Pediat, Sch Med, Denver, CO USA.
   [Brenner, Lisa A.] Univ Colorado Denver, Dept Vet Affairs, Mental Illness Res Educ & Clin Ctr, Sch Med, Denver, CO USA.
   [Brenner, Lisa A.] Univ Colorado Denver, Dept Psychiat, Sch Med, Denver, CO USA.
   [Brenner, Lisa A.] Univ Colorado Denver, Dept Neurol, Sch Med, Denver, CO USA.
   [Brenner, Lisa A.] Univ Colorado Denver, Dept Phys Med & Rehabil, Sch Med, Denver, CO USA.
RP Terrio, HP (reprint author), USA, Western Reg Med Command, Bldg 2006,Liggett Ave,Room 317,Mail Stop 109,Box, Jblm, WA 98433 USA.
EM heidi.terrio@amedd.army.mil
NR 32
TC 21
Z9 21
U1 0
U2 1
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 0090-5550
J9 REHABIL PSYCHOL
JI Rehabil. Psychol.
PD FEB
PY 2011
VL 56
IS 1
BP 26
EP 31
DI 10.1037/a0022685
PG 6
WC Psychology, Clinical; Rehabilitation
SC Psychology; Rehabilitation
GA 735LZ
UT WOS:000288417400003
PM 21401283
ER

PT J
AU Grady, JL
   Entin, EB
   Entin, EE
   Brunye, TT
AF Grady, Janet L.
   Entin, Eileen B.
   Entin, Elliot E.
   Brunye, Tad T.
TI Using message framing to achieve long-term behavioral changes in persons
   with diabetes
SO APPLIED NURSING RESEARCH
LA English
DT Article
ID GAIN-FRAMED MESSAGES; SELF-MANAGEMENT; FOOT ULCERS; ATTITUDES; WOMEN
AB This study examines how the framing of educational information affects changes in health-related knowledge, attitudes, and behavior. Patients with diabetes viewed either a gain- or a loss-framed informational video about proper foot care and its importance for the prevention of health-threatening problems. The gain-framed messages sustained long-term positive behavioral change. Regression analyses showed that changes in attitudes were predicted by changes in knowledge and that both framing and attitudes were predictors of long-term behavior. This study is important for nurses and certified diabetes educators in that it demonstrates that gain-framed messages are effective in sustaining health-promoting behavior. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Entin, Eileen B.; Entin, Elliot E.] Aptima Inc, Woburn, MA 01801 USA.
   [Grady, Janet L.] Univ Pittsburgh, Johnstown, PA 15904 USA.
   [Brunye, Tad T.] USA, NSRDEC, Natick, MA 01760 USA.
RP Entin, EB (reprint author), Aptima Inc, Woburn, MA 01801 USA.
EM ebe@aptima.com
FU Office of Naval Research [N00014-04-1-0825]; Conemaugh Diabetes
   Institute, Johnstown, PA; Telehealth Department, Mount Aloysius College,
   Cresson, PA
FX This study was funded as part of Office of Naval Research Award No.
   N00014-04-1-0825 and administered by the Henry M. Jackson Foundation,
   Rockville, MD. The authors gratefully acknowledge the support of (a)
   Carol Harding, RN, manager; Antoinette Frank, RN, CDE; and the Conemaugh
   Diabetes Institute, Johnstown, PA; (b) J. Brad Ummer, Flipside Media,
   Inc., Glenshaw, PA; and the (c) Telehealth Department, Mount Aloysius
   College, Cresson, PA. The opinions expressed in this article represent
   the opinions of the authors and in no way reflect the endorsement or
   official positions of the Office of Naval Research or the Department of
   Defense.
NR 25
TC 3
Z9 3
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0897-1897
EI 1532-8201
J9 APPL NURS RES
JI Appl. Nurs. Res.
PD FEB
PY 2011
VL 24
IS 1
BP 22
EP 28
DI 10.1016/j.apnr.2009.03.007
PG 7
WC Nursing
SC Nursing
GA 722WG
UT WOS:000287465400004
PM 20974059
ER

PT J
AU Louise, M
   Pitt, M
AF Louise, M.
   Pitt, M.
TI Symp IIIc Aerobiology and Toxicology Exposure Studies With Nonhuman
   Primate Models
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Meeting Abstract
CT 31st Annual Meeting of the American-College-of-Toxicology
CY NOV 07-10, 2010
CL Baltimore, MD
SP Amer Coll Toxicol
DE aerosol; nonhuman primate models; animal rule
C1 [Louise, M.; Pitt, M.] USA, Res Inst Infect Dis, Frederick, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD FEB
PY 2011
VL 30
IS 1
BP 118
EP 118
PG 1
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 733RJ
UT WOS:000288280200081
ER

PT J
AU Jiang, RZ
   Rong, C
   Chu, DR
AF Jiang, Rongzhong
   Rong, Charles
   Chu, Deryn
TI Surface coverage of Pt atoms on PtCo nanoparticles and catalytic
   kinetics for oxygen reduction
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE Metal nanoparticle; Oxygen reduction kinetics; Microemulsion; Catalysts
ID METHANOL FUEL-CELLS; PLATINUM-RUTHENIUM NANOPARTICLES; MICROEMULSION
   METHOD; ACIDIC MEDIA; PT3CO ALLOY; ELECTROCHEMICAL METHODS;
   ELECTRODE-KINETICS; NANOCAPSULE METHOD; MESOPOROUS CARBON; REVERSE
   MICELLE
AB The surface coverage of Pt atoms on PtCo nanoparticles and its effect on catalytic kinetics for oxygen reduction were investigated. The PtCo nanoparticles with different surface coverage of Pt atoms were synthesized with various methods, including normal chemical method, microemulsion synthesis, and ultrasound-assisted microemulsion. A model of Pt atoms filling into a spherical nanoparticle was proposed to explain the relationship of surface metal atoms and nanoparticle size. The catalytic activity of the PtCo nano-particles is highly dependent on the synthetic methods, even if they have the same chemical composition. The PtCo nano-particles synthesized with ultrasound-assisted microemulsion showed the highest activity, which is attributed to an increase of active surface coverage of Pt atoms on the metal nanoparticles. The rate of oxygen reduction at 0.5 V (vs. SCE) catalyzed by the PtCo synthesized with ultrasound-assisted micro-emulsion was about four times higher than that of the PtCo synthesized with normal chemical method. As demonstrated with rotating-ring disk electrode measurement, the PtCo nano-particles can catalyze oxygen 4-electron reduction to water without intermediate H(2)O(2) detected. Published by Elsevier Ltd.
C1 [Jiang, Rongzhong; Rong, Charles; Chu, Deryn] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Jiang, RZ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM rongzhong.jiang@us.army.mil
FU U.S. Army Research Laboratory
FX The authors wish to thank Professor Chunsheng Wang and Dr. Li-Chung Lai
   at University of Maryland for assisting TEM analysis, Dr. Cynthia
   Lundgren for helpful discussions, and the Director's Research Initiative
   Program of the U.S. Army Research Laboratory for financial support. In
   addition, we would like to thank the reviewers for giving very useful
   comments.
NR 66
TC 10
Z9 10
U1 2
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD FEB 1
PY 2011
VL 56
IS 5
BP 2532
EP 2540
DI 10.1016/j.electacta.2010.11.060
PG 9
WC Electrochemistry
SC Electrochemistry
GA 732YZ
UT WOS:000288227800087
ER

PT J
AU Benavides, LC
   Sears, AK
   Gates, JD
   Clifton, GT
   Clive, KS
   Carmichael, MG
   Holmes, JP
   Mittendorf, EA
   Ponniah, S
   Peoples, GE
AF Benavides, Linda C.
   Sears, Alan K.
   Gates, Jeremy D.
   Clifton, Guy T.
   Clive, Kevin S.
   Carmichael, Mark G.
   Holmes, Jarrod P.
   Mittendorf, Elizabeth A.
   Ponniah, Sathibalan
   Peoples, George E.
TI Comparison of different HER2/neu vaccines in adjuvant breast cancer
   trials: implications for dosing of peptide vaccines
SO EXPERT REVIEW OF VACCINES
LA English
DT Review
DE AE37 peptide; dose reduction; E75 peptide; GM-CSF; GP2 peptide; HER2/neu
   peptide vaccine
ID GROUP-STUDY I-01; T-CELL IMMUNITY; I CLINICAL-TRIAL; E75 VACCINE;
   PROSTATE-CANCER; INVARIANT CHAIN; RECURRENCE; RESPONSES; EPITOPE;
   IMMUNIZATION
AB We have performed multiple adjuvant clinical trials using immunogenic peptides from the HER2/neu protein (AE37/E75/GP2) plus (GM-CSF) given intradermally to breast cancer patients. Four trials were performed with similar dose-escalation design with increasing doses of peptide (AE37/E75/GP2) and varying amounts of GM-CSF. Dose reductions (DRs) were made for significant local and/or systemic toxicity by decreasing GM-CSF for subsequent inoculations. Ex vivo and in vivo immunologic responses were used to compare groups. Of 132 patients, 39 required DR (30 for robust local reactions [DR-L]). DR patients, particularly DR-L, had greater immune responses both ex vivo and in vivo. Postvaccine delayed-type hypersensitivity in DR-L patients compared with all others was larger for E75 (p = 0.001), AE37 (p = 0.077) and GP2 (p = 0.076). All three peptide vaccines were safe and well-tolerated. These findings have led to a clinically relevant optimal vaccine dosing strategy, which may be applicable to other peptide-based cancer vaccines.
C1 [Benavides, Linda C.; Sears, Alan K.; Gates, Jeremy D.; Clifton, Guy T.; Clive, Kevin S.; Peoples, George E.] Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, Houston, TX 78234 USA.
   [Carmichael, Mark G.; Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Dept Surg, United States Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA.
   [Holmes, Jarrod P.] USN, San Diego Med Ctr, Dept Hematol & Med Oncol, San Diego, CA 92134 USA.
   [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77230 USA.
RP Peoples, GE (reprint author), Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, 3851 Roger Brooke Dr, Houston, TX 78234 USA.
EM george.peoples@us.army.mil
FU United States Military Cancer Institute; Department of Surgery;
   Uniformed Services University of the Health Sciences; Department of
   Clinical Investigation, Walter Reed Army Medical Center, Washington DC,
   USA; Antigen Express, Inc., Worchester, MA, USA [I-01, I-02, I-03]
FX Supported by the United States Military Cancer Institute, Department of
   Surgery, Uniformed Services University of the Health Sciences, and the
   Department of Clinical Investigation, Walter Reed Army Medical Center,
   Washington DC, USA. Study I-01 and I-02 are primarily funded by the
   Clinical Breast Care Project. Study I-03 is funded by Antigen Express,
   Inc., Worchester, MA, USA. This work represents original research that
   has not been submitted elsewhere for publication. George E Peoples has
   partial inventor rights to all three vaccines which have been licensed
   for commercial development based on these results. George E Peoples is
   entitled to financial proceeds associated with these licenses per
   Federal policy and may assist these companies in the development of the
   vaccines. The authors have no other relevant affiliations or financial
   involvement with any organization or entity with a financial interest in
   or financial conflict with the subject matter or materials discussed in
   the manuscript apart from those disclosed.
NR 31
TC 12
Z9 16
U1 1
U2 8
PU EXPERT REVIEWS
PI LONDON
PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB,
   ENGLAND
SN 1476-0584
J9 EXPERT REV VACCINES
JI Expert Rev. Vaccines
PD FEB
PY 2011
VL 10
IS 2
BP 201
EP 210
DI 10.1586/ERV.10.167
PG 10
WC Immunology
SC Immunology
GA 732NM
UT WOS:000288192200012
PM 21332269
ER

PT J
AU Romero, SA
   Moralez, G
   Rickards, CA
   Ryan, KL
   Convertino, VA
   Fogt, DL
   Cooke, WH
AF Romero, Steven A.
   Moralez, Gilbert
   Rickards, Caroline A.
   Ryan, Kathy L.
   Convertino, Victor A.
   Fogt, Donovan L.
   Cooke, William H.
TI Control of cerebral blood velocity with furosemide-induced hypovolemia
   and upright tilt
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE orthostatic intolerance; hypovolemia; cerebral hemodynamics
ID HEAD-DOWN-TILT; ORTHOSTATIC STRESS; BAROREFLEX SENSITIVITY; INSPIRATORY
   RESISTANCE; FLOW VELOCITY; HUMANS; AUTOREGULATION; VASOCONSTRICTION;
   FLUCTUATIONS; DEHYDRATION
AB The purpose of this study was to test the hypothesis that exacerbated reductions of cerebral blood velocity (CBV) during upright tilt with dehydration are associated with impaired cerebrovascular control. Nine healthy men were tilted head-up (HUT) to 70 degrees for 10 min on two occasions separated by 7 days under euhydration (EUH) and dehydration (DEH; 40 mg of furosemide and water restriction) conditions. Beat-by-beat arterial pressures and CBV were measured during a 5-min supine baseline and during the first (T1) and last (T2) 5 min of HUT. Cerebral autoregulation and arterial baroreflex sensitivity were assessed in the frequency domain with cross-spectral techniques. DEH reduced plasma volume by 10% (P = 0.008) and supine mean CBV (CBV(mean)) by 11% (P = 0.002). Mean arterial pressure (MAP), stroke volume, and baroreflex sensitivity decreased during HUT (P <= 0.002), but absolute reductions were similar between hydration conditions, with the exception of stroke volume, which was lower at T1 during DEH than EUH (P = 0.04). CBV(mean) during DEH was lower (7 cm/s) over the course of the entire 10 min of HUT (P <= 0.004) than during EUH. Low-frequency oscillations (0.07-0.2 Hz) of MAP and CBV(mean) and MAP-CBV(mean) coherence were higher during DEH than EUH at T1 (P <= 0.02), but not at T2. Our results suggest that increased coherence between arterial pressure and CBV with the combination of DEH and HUT are indicative of altered cerebrovascular control. Increased CBV oscillations with DEH may reflect acute protective mechanisms to ensure adequate cerebral perfusion under conditions of reduced central blood volume.
C1 [Romero, Steven A.; Moralez, Gilbert; Rickards, Caroline A.; Fogt, Donovan L.; Cooke, William H.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA.
   [Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Cooke, WH (reprint author), Univ Texas San Antonio, Dept Hlth & Kinesiol, 1 UTSA Circle, San Antonio, TX 78249 USA.
EM william.cooke@utsa.edu
FU Texas Chapter of the American College of Sports Medicine
FX LThis study was funded by a Student Research Development Grant from the
   Texas Chapter of the American College of Sports Medicine (to S. A.
   Romero).
NR 38
TC 14
Z9 14
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD FEB
PY 2011
VL 110
IS 2
BP 492
EP 498
DI 10.1152/japplphysiol.01060.2010
PG 7
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA 732RO
UT WOS:000288207100024
PM 21109596
ER

PT J
AU De Luigi, AJ
   Fitzpatrick, KF
AF De Luigi, Arthur J.
   Fitzpatrick, Kevin F.
TI Physical Examination in Radiculopathy
SO PHYSICAL MEDICINE AND REHABILITATION CLINICS OF NORTH AMERICA
LA English
DT Article
DE physical examination; Radiculopathy; Lumbar; Cervical
ID LOW-BACK-PAIN; LUMBAR DISC HERNIATION; LEG RAISING TEST; NERVE ROOT
   COMPRESSION; 2000-2010 TASK-FORCE; CERVICAL RADICULOPATHY; NECK PAIN;
   CLINICAL-EVALUATION; SURGICAL-MANAGEMENT; BRACHIAL-PLEXUS
AB History and physical examination is the cornerstone in the appropriate diagnosis and treatment of any patient. A comprehensive physical examination is necessary to aid in determining distributions of symptoms and to lead one to the site of pathology. The aim of this article is to aid the clinician in distinguishing radiculopathy from other causes of neck and low back pain. Physical examination of the patient with suspected radiculopathy needs to be thorough and complete to make the most accurate diagnosis. Thorough knowledge of the evidence-based literature is beneficial in maximizing patient care, particularly in the light of health care reform.
C1 [De Luigi, Arthur J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Phys Med & Rehabil Serv, Washington, DC 20307 USA.
   [De Luigi, Arthur J.; Fitzpatrick, Kevin F.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
RP De Luigi, AJ (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Phys Med & Rehabil Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM arthur.deluigi@us.army.mil
NR 137
TC 9
Z9 9
U1 1
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1047-9651
J9 PHYS MED REH CLIN N
JI Phys. Med. Rehabil. Clin. N. Am.
PD FEB
PY 2011
VL 22
IS 1
BP 7
EP +
DI 10.1016/j.pmr.2010.10.003
PG 35
WC Rehabilitation
SC Rehabilitation
GA 732ZH
UT WOS:000288228700004
PM 21292143
ER

PT J
AU Riviere, LA
   Kendall-Robbins, A
   McGurk, D
   Castro, CA
   Hoge, CW
AF Riviere, Lyndon A.
   Kendall-Robbins, Athena
   McGurk, Dennis
   Castro, Carl A.
   Hoge, Charles W.
TI Coming home may hurt: risk factors for mental ill health in US
   reservists after deployment in Iraq
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; NATIONAL-GUARD SOLDIERS; SOCIAL SUPPORT;
   GULF-WAR; VIETNAM VETERANS; ACTIVE-DUTY; COMBAT; UNEMPLOYMENT; SYMPTOMS;
   CARE
AB Background
   Little research has been conducted on the factors that may explain the higher rates of mental health problems in United States National Guard soldiers who have deployed to the Iraq War.
   Aims
   To examine whether financial hardship, job loss, employer support and the effect of deployment absence on co-workers were associated with depression and post-traumatic stress disorder (PTSD).
   Method
   Cross-sectional data were obtained from 4034 National Guard soldiers at two time points. All measures were assessed by self-report.
   Results
   The four factors were associated with depression and PTSD, with variability based on outcome and time point. For example, job loss increased the odds of meeting criteria for depression at 3 and 12 months and for PTSD at 12 months; the negative effect of deployment absence on co-workers increased the likelihood of meeting criteria for PTSD, but not depression, at both time points.
   Conclusions
   The findings demonstrate that National Guard soldiers have unique post-deployment social and material concerns that impair their mental health.
C1 [Riviere, Lyndon A.; Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Silver Spring, MD 20910 USA.
   [Kendall-Robbins, Athena] Def Ctr Excellence, Def & Vet Brain Injury Ctr, Rockville, MD USA.
   [McGurk, Dennis] USA, Med Res Unit Europe, Heidelberg, Germany.
   [Castro, Carl A.] USA, Med Res & Mat Command, Ft Detrick, MD USA.
RP Riviere, LA (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM lyndon.riviere@amedd.army.mil
RI Schueter, nicos/A-3625-2014
NR 33
TC 32
Z9 32
U1 3
U2 11
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
   ENGLAND
SN 0007-1250
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD FEB
PY 2011
VL 198
IS 2
BP 136
EP 142
DI 10.1192/bjp.bp.110.084863
PG 7
WC Psychiatry
SC Psychiatry
GA 719BE
UT WOS:000287173400011
PM 21282784
ER

PT J
AU Sloop, JC
   Boyle, PD
   Fountain, AW
   Pearman, WF
   Swann, JA
AF Sloop, Joseph C.
   Boyle, Paul D.
   Fountain, Augustus W.
   Pearman, William F.
   Swann, Jacob A.
TI Electron-Deficient Aryl beta-Diketones: Synthesis and Novel Tautomeric
   Preferences
SO EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
LA English
DT Article
DE Ketones; Enols; Tautomerism; Keto-enol equilibrium; 1,3-Diketones
ID SPECTROSCOPY; C-13
AB Fluorinated aryl beta-diketones were prepared using Claisen and electrophilic fluorination methods. The keto-enol and enol-enol tautomerism of these compounds were examined in the solid state, as neat liquids and in polar, aprotic solution by crystallography and spectroscopy. Neat-liquid spectroscopic measurements as well as single crystal X-ray crystallographic results for selected electron-deficient aryl beta-diketones suggest a single, chelated cis-enol isomer that is conjugated with the aryl ring. In polar aprotic solvents, nonfluorinated aryl beta-diketones equilibrate rapidly from the chelated cis-enol form to a tautomeric mixture of cis-chelated enol and a substantial proportion of the diketone form, tri-fluoromethylated aryl beta-diketones show only limited equilibration from the chelated cis-enol to the diketone form, with 2-fluoro-1-aryl beta-diketones again displaying only the diketonic form.
C1 [Sloop, Joseph C.] Georgia Gwinnett Coll, Sch Sci & Technol, Lawrenceville, GA 30043 USA.
   [Boyle, Paul D.] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA.
   [Fountain, Augustus W.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
   [Pearman, William F.; Swann, Jacob A.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
RP Sloop, JC (reprint author), Georgia Gwinnett Coll, Sch Sci & Technol, 1000 Univ Ctr Lane, Lawrenceville, GA 30043 USA.
EM jsloop@ggc.edu
OI Sloop, Joseph/0000-0001-7639-0234
FU Georgia Gwinnett College (GGC); USMA
FX The authors would like to thank the Georgia Gwinnett College (GGC) and
   USMA Faculty Research Funds for providing financial support for this
   work, USMA Photonics Research Center for Raman support and the NCSU
   X-ray facility for crystallographic support. The views expressed in this
   academic research paper are those of the authors and do not necessarily
   reflect the official policy or position of the U.S. Government, the
   Department of Defense, or any of its agencies.
NR 15
TC 8
Z9 8
U1 0
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1434-193X
J9 EUR J ORG CHEM
JI Eur. J. Org. Chem.
PD FEB
PY 2011
IS 5
BP 936
EP 941
DI 10.1002/ejoc.201001451
PG 6
WC Chemistry, Organic
SC Chemistry
GA 718YU
UT WOS:000287163400012
ER

PT J
AU Zhang, ZL
   Chatterjee, A
   Grein, C
   Ciani, AJ
   Chung, PW
AF Zhang, Zhenli
   Chatterjee, Alok
   Grein, Christoph
   Ciani, Anthony J.
   Chung, Peter W.
TI Molecular Dynamics Simulation of MBE Growth of CdTe/ZnTe/Si
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE CdTe/ZnTe/Si; MBE; molecular dynamics; simulations
ID FOCAL-PLANE ARRAYS; BEAM EPITAXIAL-GROWTH; KINETIC MONTE-CARLO;
   NANOSTRUCTURED MATERIALS; HETEROEPITAXIAL FILMS; SUBSTRATE ORIENTATION;
   CDTE HETEROEPITAXY; ELASTIC-ANISOTROPY; HGCDTE; SILICON
AB We simulate in three dimensions molecular beam epitaxial (MBE) growth of CdTe/ZnTe/Si using classical molecular dynamics. Atomic interactions are simulated with Stillinger-Weber potentials, whose parameters are obtained by fitting to experimental data or density function theory-calculated distortion energies of the component crystals. The effects of substrate temperature and atomic species flux ratios on epilayer morphology are investigated. The agreement between simulations and experiments suggests that this model has reasonable ability to predict the microstructures of CdTe/ZnTe/Si grown by MBE.
C1 [Zhang, Zhenli; Chatterjee, Alok; Grein, Christoph] EPIR Technol Inc, Bolingbrook, IL 60440 USA.
   [Ciani, Anthony J.; Chung, Peter W.] USA, Res Lab, Aberdeen, MD USA.
RP Zhang, ZL (reprint author), EPIR Technol Inc, Bolingbrook, IL 60440 USA.
EM zlzhang@epir.com
FU SBIR [W911QX-07-C-0092]
FX This work was supported by Army SBIR Contract No. W911QX-07-C-0092. We
   thank Dr. Richard Kodama, Dr. James Garland, and Dr. Michael Carmody for
   helpful discussions. Computing resources from the DoD Supercomputing
   Resource Center at the U.S. Army Research Laboratory are gratefully
   acknowledged.
NR 65
TC 4
Z9 4
U1 2
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD FEB
PY 2011
VL 40
IS 2
BP 109
EP 121
DI 10.1007/s11664-010-1422-y
PG 13
WC Engineering, Electrical & Electronic; Materials Science,
   Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA 728GF
UT WOS:000287861900002
ER

PT J
AU Joh, J
   del Alamo, JA
   Langworthy, K
   Xie, SJ
   Zheleva, T
AF Joh, Jungwoo
   del Alamo, Jesus A.
   Langworthy, Kurt
   Xie, Sujing
   Zheleva, Tsvetanka
TI Role of stress voltage on structural degradation of GaN
   high-electron-mobility transistors
SO MICROELECTRONICS RELIABILITY
LA English
DT Article; Proceedings Paper
CT Workshop on Reliability of Compound Semiconductors (ROCS)
CY MAY 17, 2010
CL Portland, OR
AB In GaN high-electron-mobility transistors, electrical degradation due to high-voltage stress is characterized by a critical voltage at which irreversible degradation starts to take place. Separately, cross-sectional TEM analysis has revealed significant crystallographic damage for severely degraded devices. Furthermore, a close correlation between the degree of drain current degradation and material degradation has been reported. However, the role of the critical voltage in physical degradation has not been explored. In this work, we investigate the connection between electrical degradation that occurs around and beyond the critical voltage and the formation of crystallographic defects through detailed electrical and TEM analysis, respectively. We find that a groove in the GaN cap starts to be generated around the critical voltage. At higher voltages, a pit develops that penetrates into the AlGaN barrier. The size of the pit increases with stress voltage. We also observe a good correlation between electrical and material degradation. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Joh, Jungwoo; del Alamo, Jesus A.] MIT, Microsyst Technol Labs, Cambridge, MA 02139 USA.
   [Langworthy, Kurt] Univ Oregon, CAMCOR, Eugene, OR 97403 USA.
   [Xie, Sujing; Zheleva, Tsvetanka] USA, Res Lab, Adelphi, MD USA.
RP Joh, J (reprint author), 60 Vassar St,Rm 39-615, Cambridge, MA 02139 USA.
EM jungwoo@mit.edu
NR 22
TC 26
Z9 27
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0026-2714
J9 MICROELECTRON RELIAB
JI Microelectron. Reliab.
PD FEB
PY 2011
VL 51
IS 2
BP 201
EP 206
DI 10.1016/j.microrel.2010.08.021
PG 6
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
   Physics, Applied
SC Engineering; Science & Technology - Other Topics; Physics
GA 722UK
UT WOS:000287460300004
ER

PT J
AU Pamuk, ON
   Lapchak, PH
   Rani, P
   Pine, P
   Dalle Luca, JJ
   Tsokos, GC
AF Pamuk, Omer Nuri
   Lapchak, Peter H.
   Rani, Poonam
   Pine, Polly
   Dalle Luca, Jurandir J.
   Tsokos, George C.
TI SPLEEN TYROSINE KINASE INHIBITION PREVENTS TISSUE DAMAGE AFTER ISCHAEMIA
   REPERFUSION INJURY
SO RHEUMATOLOGY
LA English
DT Meeting Abstract
CT Conference on Excellence in Rheumatology
CY FEB 17-19, 2011
CL Istanbul, TURKEY
C1 [Pamuk, Omer Nuri; Lapchak, Peter H.; Rani, Poonam; Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Rheumatol, Boston, MA 02215 USA.
   [Pamuk, Omer Nuri] Trakya Univ, Sch Med, Edirne, Turkey.
   [Pine, Polly] Rigel Pharmaceut, San Francisco, CA USA.
   [Dalle Luca, Jurandir J.] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-0324
J9 RHEUMATOLOGY
JI RHEUMATOLOGY
PD FEB
PY 2011
VL 50
SU 2
BP ii1
EP ii2
DI 10.1093/rheumatology/ker092
PG 2
WC Rheumatology
SC Rheumatology
GA 716RL
UT WOS:000286991100003
ER

PT J
AU DeZee, KJ
   Maurer, D
   Colt, R
   Shimeall, W
   Mallory, R
   Powers, J
   Durning, SJ
AF DeZee, Kent J.
   Maurer, Douglas
   Colt, Ross
   Shimeall, William
   Mallory, Renee
   Powers, John
   Durning, Steven J.
TI Effect of Financial Remuneration on Specialty Choice of Fourth-Year US
   Medical Students
SO ACADEMIC MEDICINE
LA English
DT Article
ID CONTROLLABLE LIFE-STYLE; PRIMARY-CARE; INTERNAL-MEDICINE; PERCEPTIONS;
   PHYSICIAN; SELECTION; FUTURE; TRENDS; INCOME
AB Purpose
   To investigate whether financial incentives could reverse the trend of declining interest in primary care specialties among U.S. medical students.
   Method
   An electronic survey was sent to all U.S. fourth-year MD and DO medical students in 2009 with a Department of Defense service obligation. Students not selecting a primary care residency were asked if a hypothetical bonus paid before and after residency or an increase in annual salary of attendings in primary care specialties would have resulted in these students selecting primary care. Logistic regression was used to determine student characteristics associated with accepting a financial incentive.
   Results
   The survey response rate was 56% (447/797). Sixty-six percent of students did not apply for a primary care residency. Of these, 30% would have applied for primary care if they had been given a median bonus of $27,500 (interquartile range [IQR] $15,000-$50,000) before and after residency. Forty-one percent of students would have considered applying for primary care for a median military annual salary after residency of $175,000 (IQR $150,000-$200,000). Students who considered primary care but chose a controllable lifestyle specialty (e.g., radiology) were nearly four times more likely to name an influential hypothetical salary than were students who did not consider primary care and chose a noncontrollable lifestyle specialty (e.g., surgery) (67% versus 17%, P < .0001).
   Conclusions
   U.S. medical students, particularly those considering primary care but selecting controllable lifestyle specialties, are more likely to consider applying for a primary care specialty if provided a financial incentive.
C1 [DeZee, Kent J.; Durning, Steven J.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA.
   [Maurer, Douglas] Carl R Darnall Army Med Ctr, Family Med Residency Program, Ft Hood, TX USA.
   [Colt, Ross] Vicenza Hlth Clin, Clin Serv, Vicenza, Italy.
   [Shimeall, William] Natl Naval Med Ctr, Bethesda, MD USA.
   [Mallory, Renee] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   [Powers, John] Off Surg Gen, Directorate Med Educ, Falls Church, VA USA.
RP DeZee, KJ (reprint author), 4301 Jones Bridge Rd EDP, Bethesda, MD 20814 USA.
EM kent.dezee@us.army.mil
RI liu, jing/D-9482-2012
NR 24
TC 21
Z9 21
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-2446
J9 ACAD MED
JI Acad. Med.
PD FEB
PY 2011
VL 86
IS 2
BP 187
EP 193
DI 10.1097/ACM.0b013e3182045ec9
PG 7
WC Education, Scientific Disciplines; Health Care Sciences & Services
SC Education & Educational Research; Health Care Sciences & Services
GA 726BH
UT WOS:000287692000015
PM 21169785
ER

PT J
AU Fulco, CS
   Muza, SR
   Beidleman, BA
   Demes, R
   Staab, JE
   Jones, JE
   Cymerman, A
AF Fulco, Charles S.
   Muza, Stephen R.
   Beidleman, Beth A.
   Demes, Robby
   Staab, Janet E.
   Jones, Juli E.
   Cymerman, Allen
TI Effect of repeated normobaric hypoxia exposures during sleep on acute
   mountain sickness, exercise performance, and sleep during exposure to
   terrestrial altitude
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE ventilatory acclimatization; physical performance; hypobaric hypoxia;
   arterial oxygen saturation
ID SEA-LEVEL; VENTILATORY ACCLIMATIZATION; ENDURANCE PERFORMANCE; HYPOBARIC
   HYPOXIA; HUMANS; ERYTHROPOIETIN; 4,300-M; ASCENT
AB Fulco CS, Muza SR, Beidleman BA, Demes R, Staab JE, Jones JE, Cymerman A. Effect of repeated normobaric hypoxia exposures during sleep on acute mountain sickness, exercise performance, and sleep during exposure to terrestrial altitude. Am J Physiol Regul Integr Comp Physiol 300: R428-R436, 2011. First published December 1, 2010; doi: 10.1152/ajpregu.00633.2010.-There is an expectation that repeated daily exposures to normobaric hypoxia (NH) will induce ventilatory acclimatization and lessen acute mountain sickness (AMS) and the exercise performance decrement during subsequent hypobaric hypoxia (HH) exposure. However, this notion has not been tested objectively. Healthy, unacclimatized sea-level (SL) residents slept for 7.5 h each night for 7 consecutive nights in hypoxia rooms under NH [n = 14, 24 +/- 5 (SD) yr] or "sham" (n = 9, 25 +/- 6 yr) conditions. The ambient percent O(2) for the NH group was progressively reduced by 0.3% [150 m equivalent (equiv)] each night from 16.2% (2,200 m equiv) on night 1 to 14.4% (3,100 m equiv) on night 7, while that for the ventilatory- and exercise-matched sham group remained at 20.9%. Beginning at 25 h after sham or NH treatment, all subjects ascended and lived for 5 days at HH (4,300 m). End-tidal PCO(2), O(2) saturation (SaO(2)), AMS, and heart rate were measured repeatedly during daytime rest, sleep, or exercise (11.3-km treadmill time trial). From pre- to posttreatment at SL, resting end- tidal PCO(2) decreased (P < 0.01) for the NH (from 39 +/- 3 to 35 +/- 3 mmHg), but not for the sham (from 39 +/- 2 to 38 +/- 3 mmHg), group. Throughout HH, only sleep SaO(2) was higher (80 +/- 1 vs. 76 +/- 1%, P +/- 0.05) and only AMS upon awakening was lower (0.34 +/- 0.12 vs. 0.83 +/- 0.14, P +/- 0.02) in the NH than the sham group; no other between-group rest, sleep, or exercise differences were observed at HH. These results indicate that the ventilatory acclimatization induced by NH sleep was primarily expressed during HH sleep. Under HH conditions, the higher sleep SaO(2) may have contributed to a lessening of AMS upon awakening but had no impact on AMS or exercise performance for the remainder of each day.
C1 [Fulco, Charles S.; Muza, Stephen R.; Beidleman, Beth A.; Demes, Robby; Staab, Janet E.; Jones, Juli E.; Cymerman, Allen] USA, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
RP Fulco, CS (reprint author), USARIEM, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA.
EM Charles.fulco@us.army.mil
NR 28
TC 28
Z9 28
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD FEB
PY 2011
VL 300
IS 2
BP R428
EP R436
DI 10.1152/ajpregu.00633.2010
PG 9
WC Physiology
SC Physiology
GA 715JS
UT WOS:000286881400024
PM 21123763
ER

PT J
AU Javitt, MC
AF Javitt, Marcia C.
TI Preventable and Self-Inflicted Disease in Women: Hippocrates Redux
SO AMERICAN JOURNAL OF ROENTGENOLOGY
LA English
DT Editorial Material
ID PREVALENCE; MORTALITY; YEAR-2000; OBESITY
C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Javitt, MC (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 42
TC 0
Z9 0
U1 0
U2 3
PU AMER ROENTGEN RAY SOC
PI RESTON
PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA
SN 0361-803X
J9 AM J ROENTGENOL
JI Am. J. Roentgenol.
PD FEB
PY 2011
VL 196
IS 2
BP 245
EP 248
DI 10.2214/AJR.10.5019
PG 4
WC Radiology, Nuclear Medicine & Medical Imaging
SC Radiology, Nuclear Medicine & Medical Imaging
GA 718OZ
UT WOS:000287135600003
PM 21257871
ER

PT J
AU Turbyville, J
   Gada, S
   Payne, K
   Laubach, S
   Callahan, CW
   Nelson, M
AF Turbyville, Joseph
   Gada, Satyen
   Payne, Kathryn
   Laubach, Susan
   Callahan, Charles W.
   Nelson, Michael
TI Posttussive emesis as a symptom of asthma in children
SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
LA English
DT Article
ID GASTROESOPHAGEAL-REFLUX; AIRWAY-OBSTRUCTION; VALIDATION; PERTUSSIS
AB Background: Emesis can be triggered by cough in children, and cough is a common symptom of asthma.
   Objective: To explore the association between posttussive emesis and asthma in the pediatric population.
   Methods: A questionnaire was distributed to parents of children between the ages of 2 and 17 years in the pediatric and allergy-immunology clinics at our institution from August 16 through November 3, 2008. Prevalence of posttussive emesis was determined and compared among children with physician-diagnosed asthma, children with no evidence of asthma, and those not formally diagnosed as having asthma but with surrogate markers suggestive of asthma. The predictive value of posttussive emesis was compared with those of known markers of asthma. The prevalence of gastroesophageal reflux and pertussis was evaluated because these conditions might also cause posttussive emesis.
   Results: The prevalence of posttussive emesis was 33% in our study population of 500 children. Among those with physician-diagnosed asthma (n = 122), 56% reported a history of posttussive emesis. For patients not formally diagnosed as having asthma but with surrogate markers suggestive of asthma (n = 62), 71% had a history of posttussive emesis. Both of these were significantly higher than in those with no evidence of asthma (n = 316), in whom 16% reported a history of posttussive emesis (P < .0005). Children with posttussive emesis were significantly more likely to have asthma than those without posttussive emesis (odds ratio, 7.9; 95% confidence interval, 5.2-12). Neither pertussis nor gastroesophageal reflux accounted for the degree of posttussive emesis reported.
   Conclusions: Posttussive emesis is more common among children with asthma than among nonasthmatic children. In children with cough and a history of posttussive emesis, asthma should be strongly considered in the differential diagnosis. Ann Allergy Asthma Immunol. 2011;106:140 145.
C1 [Turbyville, Joseph; Gada, Satyen; Payne, Kathryn; Laubach, Susan; Callahan, Charles W.; Nelson, Michael] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
RP Turbyville, J (reprint author), Ireland Army Community Hosp, Dept Allergy Immunol, 851 Ireland Loop, Ft Knox, KY USA.
EM joseph.c.turbyville@us.army.mil
OI Gada, Satyen/0000-0003-3539-5543
NR 21
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1081-1206
J9 ANN ALLERG ASTHMA IM
JI Ann. Allergy Asthma Immunol.
PD FEB
PY 2011
VL 106
IS 2
BP 140
EP 145
DI 10.1016/j.anai.2010.11.012
PG 6
WC Allergy; Immunology
SC Allergy; Immunology
GA 721VU
UT WOS:000287386700010
PM 21277515
ER

PT J
AU Louie, A
   Heine, HS
   VanScoy, B
   Eichas, A
   Files, K
   Fikes, S
   Brown, DL
   Liu, W
   Kinzig-Schippers, M
   Sorgel, F
   Drusano, GL
AF Louie, A.
   Heine, H. S.
   VanScoy, B.
   Eichas, A.
   Files, K.
   Fikes, S.
   Brown, D. L.
   Liu, W.
   Kinzig-Schippers, M.
   Soergel, F.
   Drusano, G. L.
TI Use of an In Vitro Pharmacodynamic Model To Derive a Moxifloxacin
   Regimen That Optimizes Kill of Yersinia pestis and Prevents Emergence of
   Resistance
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID BACILLUS-ANTHRACIS; PNEUMONIC PLAGUE; INFECTION MODEL; MURINE THIGH;
   CIPROFLOXACIN; FLUOROQUINOLONE; DOXYCYCLINE; THERAPY; PHARMACOKINETICS;
   GATIFLOXACIN
AB Yersinia pestis, the causative agent of bubonic, septicemic, and pneumonic plague, is classified as a CDC category A bioterrorism pathogen. Streptomycin and doxycycline are the "gold standards" for the treatment of plague. However, streptomycin is not available in many countries, and Y. pestis isolates resistant to streptomycin and doxycycline occur naturally and have been generated in laboratories. Moxifloxacin is a fluoroquinolone antibiotic that demonstrates potent activity against Y. pestis in in vitro and animal infection models. However, the dose and frequency of administration of moxifloxacin that would be predicted to optimize treatment efficacy in humans while preventing the emergence of resistance are unknown. Therefore, dose range and dose fractionation studies for moxifloxacin were conducted for Y. pestis in an in vitro pharmacodynamic model in which the half-lives of moxifloxacin in human serum were simulated so as to identify the lowest drug exposure and the schedule of administration that are linked with killing of Y. pestis and with the suppression of resistance. In the dose range studies, simulated moxifloxacin regimens of >= 175 mg/day killed drug-susceptible bacteria without resistance amplification. Dose fractionation studies demonstrated that the AUC (area under the concentration-time curve)/MIC ratio predicted kill of drug-susceptible Y. pestis, while the C(max) (maximum concentration of the drug in serum)/MIC ratio was linked to resistance prevention. Monte Carlo simulations predicted that moxifloxacin at 400 mg/day would successfully treat human infection due to Y. pestis in 99.8% of subjects and would prevent resistance amplification. We conclude that in an in vitro pharmacodynamic model, the clinically prescribed moxifloxacin regimen of 400 mg/day is predicted to be highly effective for the treatment of Y. pestis infections in humans. Studies of moxifloxacin in animal models of plague are warranted.
C1 [Louie, A.; VanScoy, B.; Eichas, A.; Files, K.; Fikes, S.; Brown, D. L.; Liu, W.; Drusano, G. L.] Ordway Res Inst, Albany, NY 12208 USA.
   [Heine, H. S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
   [Kinzig-Schippers, M.; Soergel, F.] Inst Biomed & Pharmaceut Res, Nurnberg, Germany.
RP Louie, A (reprint author), Ordway Res Inst, 150 New Scotland Ave, Albany, NY 12208 USA.
EM alouie@ordwayresearch.org
FU National Institute of Allergy and Infectious Diseases [P01AI060908]
FX This work was supported by grant P01AI060908 from the National Institute
   of Allergy and Infectious Diseases.
NR 43
TC 9
Z9 10
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD FEB
PY 2011
VL 55
IS 2
BP 822
EP 830
DI 10.1128/AAC.00818-10
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 709FE
UT WOS:000286422500048
PM 21115791
ER

PT J
AU Melendrez, MC
   Lange, RK
   Cohan, FM
   Ward, DM
AF Melendrez, Melanie C.
   Lange, Rachel K.
   Cohan, Frederick M.
   Ward, David M.
TI Influence of Molecular Resolution on Sequence-Based Discovery of
   Ecological Diversity among Synechococcus Populations in an Alkaline
   Siliceous Hot Spring Microbial Mat
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID GRADIENT GEL-ELECTROPHORESIS; YELLOWSTONE-NATIONAL-PARK; RNA-DEFINED
   POPULATIONS; NONPARAMETRIC-ESTIMATION; CYANOBACTERIAL ECOTYPES;
   BACTERIAL SYSTEMATICS; SPECIES DEFINITION; FUNDAMENTAL UNITS; TYPING
   DATA; COMMUNITY
AB Previous research has shown that sequences of 16S rRNA genes and 16S-23S rRNA internal transcribed spacer regions may not have enough genetic resolution to define all ecologically distinct Synechococcus populations (ecotypes) inhabiting alkaline, siliceous hot spring microbial mats. To achieve higher molecular resolution, we studied sequence variation in three protein-encoding loci sampled by PCR from 60 degrees C and 65 degrees C sites in the Mushroom Spring mat (Yellowstone National Park, WY). Sequences were analyzed using the ecotype simulation (ES) and AdaptML algorithms to identify putative ecotypes. Between 4 and 14 times more putative ecotypes were predicted from variation in protein-encoding locus sequences than from variation in 16S rRNA and 16S-23S rRNA internal transcribed spacer sequences. The number of putative ecotypes predicted depended on the number of sequences sampled and the molecular resolution of the locus. Chao estimates of diversity indicated that few rare ecotypes were missed. Many ecotypes hypothesized by sequence analyses were different in their habitat specificities, suggesting different adaptations to temperature or other parameters that vary along the flow channel.
C1 [Melendrez, Melanie C.; Lange, Rachel K.; Ward, David M.] Montana State Univ, Bozeman, MT 59717 USA.
   [Cohan, Frederick M.] Wesleyan Univ, Dept Biol, Middletown, CT 06459 USA.
RP Melendrez, MC (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM melendrezmc@afrims.org
OI Melendrez, Melanie/0000-0002-4811-4467
FU National Science Foundation [EF-0328698]; National Aeronautics and Space
   Administration Exobiology Program [NAG5-8807]; U.S. Department of Energy
   (DOE), Office of Biological and Environmental Research (BER); GSP
   Foundational Scientific Focus Area (FSFA) at the Pacific Northwest
   National Laboratory (PNNL) [112443]
FX This research was supported by the National Science Foundation Frontiers
   in Integrative Biology Research Program (EF-0328698), the National
   Aeronautics and Space Administration Exobiology Program (NAG5-8807), and
   the U.S. Department of Energy (DOE), Office of Biological and
   Environmental Research (BER), as part of BER's Genomic Science Program
   (GSP). This contribution originates from the GSP Foundational Scientific
   Focus Area (FSFA) at the Pacific Northwest National Laboratory (PNNL),
   contract no. 112443.
NR 58
TC 23
Z9 24
U1 0
U2 13
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD FEB
PY 2011
VL 77
IS 4
BP 1359
EP 1367
DI 10.1128/AEM.02032-10
PG 9
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 717WM
UT WOS:000287078100025
PM 21169433
ER

PT J
AU Ely, BR
   Ely, MR
   Cheuvront, SN
AF Ely, Brett R.
   Ely, Matthew R.
   Cheuvront, Samuel N.
TI Marginal Effects of a Large Caffeine Dose on Heat Balance During
   Exercise-Heat Stress
SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
LA English
DT Article
DE body temperature; thermoregulation; epinephrine
ID MEAN BODY-TEMPERATURE; BLOOD-PRESSURE; PERFORMANCE; FLUID; INGESTION;
   RESPONSES; ILLNESS; HUMANS
AB The use of caffeine supplements in athletic and military populations has increased in recent years. Excessive caffeine consumption in conjunction with exercise in a hot environment may predispose individuals to heat illness. Purpose: To examine heat balance induced by a large dose of caffeine during exercise in a hot environment. Methods: Ten men, not heat acclimated and not habitual caffeine users, consumed either caffeine (CAF; 9 mg/kg) or placebo (PLA) before performing cycle-ergometer exercise for 30 min at 50% VO2peak in a 40 degrees C, 25% relative humidity environment while body temperature (core and skin) and ratings of thermal comfort (TC) were monitored. Heat-exchange variables were calculated using partitional calorimetry and thermometry. Results: Mean body temperature (T-b) was higher (p < .05) with CAF (37.18 +/- 0.15 degrees C) than with PLA (36.93 +/- 0.15 degrees C) at the start of exercise. Heat production was slightly higher (similar to 8 W, p < .05) with CAF. There were no differences in heat storage, dry heat gains, TC, or T-b during exercise. Conclusions: A caffeine dose of 9 mg/kg does not appreciably alter heat balance during work in a hot environment. The small increase in T-b observed with CAF was undetected by the participants and is unlikely to increase physiological strain sufficiently to affect endurance performance or risk of heat illness.
C1 [Ely, Brett R.; Ely, Matthew R.; Cheuvront, Samuel N.] Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA.
RP Ely, BR (reprint author), Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA.
NR 37
TC 8
Z9 8
U1 1
U2 11
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1526-484X
J9 INT J SPORT NUTR EXE
JI Int. J. Sport Nutr. Exerc. Metab.
PD FEB
PY 2011
VL 21
IS 1
BP 65
EP 70
PG 6
WC Nutrition & Dietetics; Sport Sciences
SC Nutrition & Dietetics; Sport Sciences
GA 721UG
UT WOS:000287382700009
PM 21411837
ER

PT J
AU Gao, YH
   Chen, MK
   Yin, S
   Ruffin, P
   Brantley, C
   Edwards, E
AF Gao, Yaohui
   Chen, Meng-ku
   Yin, Stuart
   Ruffin, Paul
   Brantley, Christina
   Edwards, Eugene
TI Terahertz enhancement from terahertz-radiation-assisted large aperture
   photoconductive antenna
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID IMPACT IONIZATION; PULSES; ZNTE; GENERATION; EMISSION; EMITTERS
AB The observation of enhanced terahertz (THz) wave generation from the large aperture photoconductive (PC) antenna excited by both a femtosecond pump beam and a collinearly propagating ZnTe-pregenerated THz wave is reported within this paper. An analysis based on both the calculated and experimental results demonstrated that the superposition acts as the main physical mechanism of this THz enhancement effect due to the dominant contribution from the rapid change in photoexcited carrier density. A prerequisite for the THz enhancement requires that the polarization of the applied bias and the ZnTe-pregenerated THz should be identical in order to have a constructive superposition. Therefore, this observation introduces the possibility of recycling the unused portion of the pump beam to further improve the THz radiation. The enhancement effect could be optimized by changing the thickness of ZnTe, which could affect the photoexcited-free-carrier absorption of THz in the PC antenna and the bandwidth of final enhanced THz radiation. (C) 2011 American Institute of Physics. [doi:10.1063/1.3544044]
C1 [Gao, Yaohui; Chen, Meng-ku; Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
   [Ruffin, Paul; Brantley, Christina; Edwards, Eugene] US Army Aviat & Missile Res, Ctr Dev & Engn, Redstone Arsenal, AL 35898 USA.
RP Gao, YH (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
EM sxy105@psu.edu
FU ONR [N000140810538]
FX Authors greatly acknowledge the partial financial support of this work
   by an ONR basic research program (N000140810538).
NR 18
TC 5
Z9 5
U1 0
U2 13
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD FEB 1
PY 2011
VL 109
IS 3
AR 033108
DI 10.1063/1.3544044
PG 5
WC Physics, Applied
SC Physics
GA 721PC
UT WOS:000287366000009
ER

PT J
AU Asarias, JR
   Nguyen, PT
   Mings, JR
   Gehrich, AP
   Pierce, LM
AF Asarias, Jennifer R.
   Nguyen, Phuoc T.
   Mings, Jamie R.
   Gehrich, Alan P.
   Pierce, Lisa M.
TI Influence of Mesh Materials on the Expression of Mediators Involved in
   Wound Healing
SO JOURNAL OF INVESTIGATIVE SURGERY
LA English
DT Article; Proceedings Paper
CT 2010 Clinical Congress on American-Coll3ege-of-Surgeons
CY OCT 03-07, 2010
CL Washington, DC
SP Amer Coll Surg
DE synthetic mesh; hernia repair; differential expression; inflammatory
   cytokines; matrix metalloproteinase; wound healing; polypropylene;
   polyester; polytetrafluoroethylene
ID SMALL-INTESTINAL SUBMUCOSA; FOREIGN-BODY REACTION; HERNIA REPAIR;
   INCISIONAL HERNIA; RAT MODEL; BIOMATERIALS; METALLOPROTEINASES;
   CYTOKINES
AB The use of synthetic mesh for ventral hernia repair is widely accepted, but mesh-induced inflammatory responses may lead to postoperative complications. Molecular mechanisms that direct the extent of the foreign body reaction to implanted materials are poorly understood. This study compares the influence of three macroporous meshes on the expression of genes critical for wound healing and extracellular matrix remodeling in a rat model. Full thickness abdominal wall defects were corrected with polypropylene, polyester, polytetrafluoroethylene (PTFE), or suture repair with no mesh. Explants were harvested 7 or 90 days after repair and were divided for histological, immunohistochemical, and mRNA analyses. Real-time quantitative polymerase chain reaction arrays were used to profile the expression of 84 genes involved in angiogenesis at the tissue--mesh interface. Evaluation of gene expression profiles and histologic specimens revealed that polypropylene and polyester induced a greater and more persistent inflammatory response than PTFE, which elicited a response most similar to that induced by suture repair. Mesh implantation induced the differential expression (> 3-fold change and p < .01) of genes encoding inflammatory cytokines, growth factors, and extracellular matrix proteins relative to suture repair without mesh. Genes most markedly upregulated included the neutrophil chemoattractant CXCL2 and matrix metalloproteinases 3 and 9. Polyester induced the greatest number of differentially expressed genes relative to suture repair both at 7 and 90 days after implantation. Results from this study suggest that the particular type of mesh used in a hernia repair may affect the patient's wound healing response and clinical outcome.
C1 [Pierce, Lisa M.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
   [Asarias, Jennifer R.; Nguyen, Phuoc T.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA.
   [Mings, Jamie R.] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA.
   [Gehrich, Alan P.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA.
RP Pierce, LM (reprint author), Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM Lisa.Pierce@amedd.army.mil
NR 30
TC 26
Z9 28
U1 0
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0894-1939
J9 J INVEST SURG
JI J. Invest. Surg.
PD FEB
PY 2011
VL 24
IS 2
BP 87
EP 98
DI 10.3109/08941939.2010.548904
PG 12
WC Surgery
SC Surgery
GA 725UM
UT WOS:000287671600007
PM 21345009
ER

PT J
AU Lee, I
   Choi, KK
   Noh, Y
   Zhao, L
   Gorsich, D
AF Lee, Ikjin
   Choi, K. K.
   Noh, Yoojeong
   Zhao, Liang
   Gorsich, David
TI Sampling-Based Stochastic Sensitivity Analysis Using Score Functions for
   RBDO Problems With Correlated Random Variables
SO JOURNAL OF MECHANICAL DESIGN
LA English
DT Article
DE stochastic sensitivity analyses; score functions; Monte Carlo
   simulation; copula; surrogate model; RBDO
ID DIMENSION-REDUCTION METHOD; ROBUST DESIGN OPTIMIZATION; ENERGY
   FINITE-ELEMENT; MULTIDIMENSIONAL INTEGRATION; SIDE IMPACT; RELIABILITY;
   CRASHWORTHINESS; APPROXIMATION; MECHANICS; SURROGATE
AB This study presents a methodology for computing stochastic sensitivities with respect to the design variables, which are the mean values of the input correlated random variables. Assuming that an accurate surrogate model is available, the proposed method calculates the component reliability, system reliability, or statistical moments and their sensitivities by applying Monte Carlo simulation to the accurate surrogate model. Since the surrogate model is used, the computational cost for the stochastic sensitivity analysis is affordable compared with the use of actual models. The copula is used to model the joint distribution of the correlated input random variables, and the score function is used to derive the stochastic sensitivities of reliability or statistical moments for the correlated random variables. An important merit of the proposed method is that it does not require the gradients of performance functions, which are known to be erroneous when obtained from the surrogate model, or the transformation from X-space to U-space for reliability analysis. Since no transformation is required and the reliability or statistical moment is calculated in X-space, there is no approximation or restriction in calculating the sensitivities of the reliability or statistical moment. Numerical results indicate that the proposed method can estimate the sensitivities of the reliability or statistical moments very accurately, even when the input random variables are correlated. [DOI:10.1115/1.4003186]
C1 [Lee, Ikjin; Choi, K. K.; Noh, Yoojeong; Zhao, Liang] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
   [Gorsich, David] USA, RDECOM TARDEC, Warren, MI 48397 USA.
RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA.
EM ilee@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu;
   noh@engineering.uiowa.edu; liazhao@engineering.uiowa.edu;
   david.gorsich@us.army.mil
RI Zhao, Liang/F-3495-2012; Lee, IkJin/I-4722-2013; Choi,
   Kyung/B-1512-2008; Noh, Yoojeong/E-9833-2015
OI Choi, Kyung/0000-0003-2384-6220; 
FU Automotive Research Center, U.S. Army TARDEC; ARO [W911NF-09-1-0250]
FX This research is jointly supported by the Automotive Research Center,
   which is sponsored by the U.S. Army TARDEC, and ARO Project No.
   W911NF-09-1-0250. This support is greatly appreciated.
NR 45
TC 18
Z9 18
U1 0
U2 9
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1050-0472
J9 J MECH DESIGN
JI J. Mech. Des.
PD FEB
PY 2011
VL 133
IS 2
AR 021003
DI 10.1115/1.4003186
PG 10
WC Engineering, Mechanical
SC Engineering
GA 718CD
UT WOS:000287096600004
ER

PT J
AU Reddy, ALM
   Kumar, A
   Currano, LJ
   Churaman, W
   Dubey, M
   Ajayan, PM
AF Reddy, Arava Leela Mohana
   Kumar, Ashavani
   Currano, Luke J.
   Churaman, Wayne
   Dubey, Madan
   Ajayan, Pulickel M.
TI Thermal Decomposition Properties of NaClO4 Functionalized CNT Arrays
SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
LA English
DT Article
DE Multi-Walled Carbon Nanotubes (MWNT); Chemical Vapor Deposition; Thermal
   Properties; Functionalization and Sodiumperchlorate
ID SINGLE-WALLED NANOTUBES; CARBON NANOTUBES; COMPOSITE; NANOCRYSTALLINE;
   MANAGEMENT
AB Aligned CNT mats were prepared by thermal chemical vapor deposition (CVD) method by exposing a mixture of ferrocene and xylene vapor to the SiO2/Si substrates. Aligned CNT mats functionalized with reactive chemicals without disturbing CNT alignment were characterized by SEM, XRD, FT-IR, FT-Raman and XPS. The thermal stability of the CNT, CNT-OH and CNT-NaClO4 are investigated using TG-DSC analysis. Oxidation and combustion temperatures of CNT mats were found to be decreased by functionalizing the CNT mats with NaClO4.
C1 [Reddy, Arava Leela Mohana; Kumar, Ashavani; Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA.
   [Currano, Luke J.; Churaman, Wayne; Dubey, Madan] USN, Res Lab, Adelphi, MD 20783 USA.
RP Reddy, ALM (reprint author), Rice Univ, Dept Mech Engn & Mat Sci, 6100 Main St, Houston, TX 77005 USA.
RI Arava, Leela Mohana Reddy/J-3180-2015
FU US Army Research Laboratory; Rice University
FX The authors acknowledge funding support from the US Army Research
   Laboratory and Rice University.
NR 20
TC 0
Z9 0
U1 0
U2 4
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1533-4880
J9 J NANOSCI NANOTECHNO
JI J. Nanosci. Nanotechnol.
PD FEB
PY 2011
VL 11
IS 2
BP 1111
EP 1116
DI 10.1166/jnn.2011.3054
PG 6
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 718ZZ
UT WOS:000287167900029
PM 21456147
ER

PT J
AU Liacouras, P
   Garnes, J
   Roman, N
   Petrich, A
   Grant, GT
AF Liacouras, Peter
   Garnes, Jonathan
   Roman, Norberto
   Petrich, Anton
   Grant, Gerald T.
TI DESIGNING AND MANUFACTURING AN AURICULAR PROSTHESIS USING COMPUTED
   TOMOGRAPHY, 3-DIMENSIONAL PHOTOGRAPHIC IMAGING, AND ADDITIVE
   MANUFACTURING: A CLINICAL REPORT
SO JOURNAL OF PROSTHETIC DENTISTRY
LA English
DT Article
ID DEVELOPING FACIAL PROSTHESES; CAD/CAM TECHNIQUES; FABRICATION; EAR;
   INTEGRATION; CAD
AB The method of fabricating an auricular prosthesis by digitally positioning a mirror image of the soft tissue, then designing and using rapid prototyping to produce the mold, can reduce the steps and time needed to create a prosthesis by the traditional approach of sculpting either wax or clay. The purpose of this clinical report is to illustrate how the use of 3-dimensional (3-D) photography, computer technology, and additive manufacturing can extensively reduce many of the preliminary procedures currently used to create an auricular prosthesis. (J Prosthet Dent 2011;105:78-82)
C1 [Liacouras, Peter] Walter Reed Army Med Ctr, Med Applicat Ctr 3D, Dept Radiol, Washington, DC 20307 USA.
   [Petrich, Anton] USN, Sch Postgrad Dent, Natl Naval Med Ctr, Maxillofacial Prosthet Dept, Bethesda, MD 20084 USA.
   [Grant, Gerald T.] Natl Naval Med Ctr, Dept Radiol, Bethesda, MD USA.
RP Liacouras, P (reprint author), Walter Reed Army Med Ctr, Med Applicat Ctr 3D, Dept Radiol, Bldg 2,Room 1X36,6900 Georgia Ave, Washington, DC 20307 USA.
EM Peter.liacouras@amedd.army.mil
NR 11
TC 18
Z9 22
U1 2
U2 23
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3913
J9 J PROSTHET DENT
JI J. Prosthet. Dent.
PD FEB
PY 2011
VL 105
IS 2
BP 78
EP 82
DI 10.1016/S0022-3913(11)60002-4
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA 727GC
UT WOS:000287784900002
PM 21262404
ER

PT J
AU Jabbour, RE
   Deshpande, SV
   Stanford, MF
   Wick, CH
   Zulich, AW
   Snyder, AP
AF Jabbour, Rabih E.
   Deshpande, Samir V.
   Stanford, Michael F.
   Wick, Charles H.
   Zulich, Alan W.
   Snyder, A. Peter
TI A Protein Processing Filter Method for Bacterial Identification by Mass
   Spectrometry-Based Proteomics
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE Protein extraction; proteomics; microbial identification; database
   search; bacteria; liquid chromatography-mass spectrometry
ID DESORPTION-IONIZATION-TIME; BACILLUS-CEREUS GROUP;
   LIQUID-CHROMATOGRAPHY; GEL-FREE; MEMBRANE; COLI; CELL; CLASSIFICATION;
   FRACTIONATION; AUTOMATION
AB A "one-pot" alternative method for processing proteins and isolating peptide mixtures from bacterial samples is presented for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis and data reduction. The conventional in-solution digestion of the protein contents of bacteria is compared to a small disposable filter unit placed inside a centrifuge vial for processing and digestion of bacterial proteins. Each processing stage allows filtration of excess reactants and unwanted byproduct while retaining the proteins. Upon addition of trypsin, the peptide mixture solution is passed through the filter while retaining the trypsin enzyme. The peptide mixture is then analyzed by LC-MS/MS with an in-house BACid algorithm for a comparison of the experimental unique peptides to a constructed proteome database of bacterial genus, specie, and strain entries. The concentration of bacteria was varied from 10 x 10(7) to 3.3 x 10(3) cfu/mL for analysis of the effect of concentration on the ability of the sample processing, LC-MS/MS, and data analysis methods to identify bacteria. The protein processing method and dilution procedure result in reliable identification of pure suspensions and mixtures at high and low bacterial concentrations.
C1 [Jabbour, Rabih E.] SAIC, Aberdeen Proving Ground, MD 21010 USA.
   [Deshpande, Samir V.] Sci & Technol Corp, Edgewood, MD 21040 USA.
   [Stanford, Michael F.; Wick, Charles H.; Zulich, Alan W.; Snyder, A. Peter] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Jabbour, RE (reprint author), SAIC, Aberdeen Proving Ground, MD 21010 USA.
EM rabih.jabbour@us.army.mil
FU Defense Threat Reduction Agency (DTRA)
FX We thank Dr. Ilya Elashvili at the Defense Threat Reduction Agency
   (DTRA) for funding the research presented herein.
NR 30
TC 6
Z9 6
U1 0
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
J9 J PROTEOME RES
JI J. Proteome Res.
PD FEB
PY 2011
VL 10
IS 2
BP 907
EP 912
DI 10.1021/pr101086a
PG 6
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA 715GI
UT WOS:000286868500050
PM 21126090
ER

PT J
AU Henning, JS
   Firoz, B
   Schwendiman, M
AF Henning, J. Scott
   Firoz, Bahar
   Schwendiman, Mark
TI The prevalence of nonmelanoma skin cancer associated with UV nail light
   exposure
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the American-Academy-of-Dermatology
CY FEB 04-08, 2011
CL New Orleans, LA
SP Amer Acad Dermatol
C1 [Henning, J. Scott] Brooke Army Med Ctr, San Antonio Mil Med Ctr, San Antonio, TX USA.
   [Schwendiman, Mark] SAMMC Dermatol, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD FEB
PY 2011
VL 64
IS 2
SU 1
BP AB123
EP AB123
PG 1
WC Dermatology
SC Dermatology
GA 714AY
UT WOS:000286780500485
ER

PT J
AU Henning, JS
AF Henning, J. Scott
TI CASH as a method for teaching dermoscopy
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Meeting Abstract
CT 69th Annual Meeting of the American-Academy-of-Dermatology
CY FEB 04-08, 2011
CL New Orleans, LA
SP Amer Acad Dermatol
C1 [Henning, J. Scott] Brooke Army Med Ctr, San Antonio Mil Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD FEB
PY 2011
VL 64
IS 2
SU 1
BP AB118
EP AB118
PG 1
WC Dermatology
SC Dermatology
GA 714AY
UT WOS:000286780500464
ER

PT J
AU Plackett, TP
   Fleurat, J
   Putty, B
   Demetriades, D
   Plurad, D
AF Plackett, Timothy P.
   Fleurat, Jonathan
   Putty, Brad
   Demetriades, Demetrios
   Plurad, David
TI Selective Nonoperative Management of Anterior Abdominal Stab Wounds:
   1992-2008
SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
LA English
DT Article; Proceedings Paper
CT 23rd Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma
CY JAN 19-23, 2010
CL Phoenix, AZ
SP Eastern Assoc Surg Trauma
DE Nonoperative; Stab wound; Penetrating; Mortality; Morbidity
ID PHYSICAL-EXAMINATION; PERITONEAL-LAVAGE; TRAUMA; LAPAROTOMY;
   COMPLICATIONS; EXPLORATION; OPERATION; INJURIES; ORGAN
AB Background: The use of selective nonoperative management for anterior abdominal stab wounds has evolved into a readily accepted practice. Multiple reports have shown this strategy to be both safe and effective. However, there is a paucity of long-term studies.
   Methods: A retrospective review was performed of all trauma patients presenting for anterior abdominal stab wounds at a Level I trauma center during a 17-year time period. Primary outcomes were the percentage of patients undergoing an exploratory laparotomy and the negative laparotomy rate.
   Results: A total of 7,033 patients sustained a stab wound with 1,961 involving the anterior abdomen. The percentage of patients undergoing exploratory laparotomy decreased during the study period from 64.8% to 37.6% (overall 45.8%). The negative laparotomy rate decreased from 21.3% to 8.6% (overall 18.7%). The negative laparotomy rate of patients who underwent exploratory laparotomy immediately did not change over time (13.8%), whereas the negative laparotomy rate of those patients who underwent exploratory laparotomy in a delayed fashion decreased from 25.0% to 6.25%. The overall mortality was 1.9%, with 6.2% mortality for patients undergoing an immediate laparotomy, 0.7% for patients undergoing a delayed laparotomy, and 0.0% for patients managed nonoperatively (p < 0.04). The mean length of hospital stay was 6.6 days +/- 0.5 days, with a mean of 9.4 days +/- 0.9 days in patients undergoing an immediate laparotomy, 8.1 days +/- 0.5 days in patients undergo a delayed laparotomy, and 3.8 days +/- 0.2 days in patients managed nonoperatively (p < 0.001).
   Conclusions: Selective nonoperative management for stab wounds to the anterior abdomen is associated with a decreased operative rate and decreased negative laparotomy rate over time. Selective nonoperative management is both safe and effective for anterior abdominal stab wounds.
C1 [Plurad, David] LAC USC Med Ctr, Dept Surg, Div Trauma & Crit Care, Los Angeles, CA 90033 USA.
   [Plackett, Timothy P.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
RP Plurad, D (reprint author), LAC USC Med Ctr, Dept Surg, Div Trauma & Crit Care, 1200 N State St,Room 6341, Los Angeles, CA 90033 USA.
EM plurad@usc.edu
NR 18
TC 7
Z9 9
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0022-5282
J9 J TRAUMA
JI J. Trauma-Injury Infect. Crit. Care
PD FEB
PY 2011
VL 70
IS 2
BP 408
EP 413
DI 10.1097/TA.0b013e31820b5eb7
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA 719FV
UT WOS:000287187700033
PM 21307742
ER

PT J
AU Eichhorn, JH
   Crothers, BA
   Wilbur, DC
AF Eichhorn, J. H.
   Crothers, B. A.
   Wilbur, D. C.
TI Gynecologic Telecytology Using Automated Local Image Selection with
   Remote Interpretation: The Results of a Phase 2 Prospective Trial
SO LABORATORY INVESTIGATION
LA English
DT Meeting Abstract
CT 100th Annual Meeting of the United States and
   Canadian-Academy-of-Pathology
CY FEB 26-MAR 04, 2011
CL San Antonio, TX
SP Canadian Acad Pathol
C1 Massachusetts Gen Hosp, Boston, MA 02114 USA.
   Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2011
VL 91
SU 1
MA 364
BP 89A
EP 89A
PG 1
WC Medicine, Research & Experimental; Pathology
SC Research & Experimental Medicine; Pathology
GA 716ZG
UT WOS:000287011400366
ER

PT J
AU Teyhen, DS
AF Teyhen, Deydre S.
TI Rehabilitative ultrasound imaging for assessment and treatment of
   musculoskeletal conditions
SO MANUAL THERAPY
LA English
DT Article
DE Low back pain; Physical therapy; Rehabilitation; Ultrasound imaging
ID PAIN
C1 Baylor Univ, USA, ATTN MCCS HGE PT LTC Teyhen, Ft Sam Houston, TX 78234 USA.
RP Teyhen, DS (reprint author), Baylor Univ, USA, ATTN MCCS HGE PT LTC Teyhen, 3151 Scott Rd,Room 1301, Ft Sam Houston, TX 78234 USA.
EM deydre.teyhen@us.army.mil
NR 7
TC 4
Z9 5
U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1356-689X
J9 MANUAL THER
JI Man. Ther.
PD FEB
PY 2011
VL 16
IS 1
BP 44
EP 45
DI 10.1016/j.math.2010.06.012
PG 2
WC Rehabilitation
SC Rehabilitation
GA 715DA
UT WOS:000286859400010
PM 20678956
ER

PT J
AU Meirom, RA
   Alsem, DH
   Romasco, AL
   Clark, T
   Polcawich, RG
   Pulskamp, JS
   Dubey, M
   Ritchie, RO
   Muhlstein, CL
AF Meirom, Roi A.
   Alsem, Daan Hem
   Romasco, Amber L.
   Clark, Trevor
   Polcawich, Ronald G.
   Pulskamp, Jeffrey S.
   Dubey, Madan
   Ritchie, Robert O.
   Muhlstein, Christopher L.
TI Fatigue-induced grain coarsening in nanocrystalline platinum films
SO ACTA MATERIALIA
LA English
DT Article
DE Fatigue; Thin films; Platinum group
ID CRACK-PROPAGATION; METALS; COPPER; BEHAVIOR; MECHANISMS; FRICTION;
   TENSILE; DUCTILE
AB Mechanisms to explain the unique mechanical behavior of nanograined metals focus primarily on grain and grain boundary mobility. In most nanograined metal materials systems (both pure and alloyed) it has not been possible to decouple these time- and cycle-dependent contributions. In contrast, the 460 nm thick, (1 1 1) textured, nanograined platinum thin films evaluated in this work have robust grain morphologies that allow us to uniquely identify the fatigue damage accumulation processes. Unlike other reports of face-centered cubic metal behavior, the platinum films exhibited a particularly limited range of fatigue crack growth (<3 MPa root m) with extremely large (similar to 10.5) power law exponents typically associated with fatigue of structural ceramics and ordered intermetallics. Transmission electron microscopy and fatigue crack growth data suggest that the crack growth mechanism appears to be intrinsic in origin and dislocation mediated. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Meirom, Roi A.; Romasco, Amber L.; Clark, Trevor; Muhlstein, Christopher L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
   [Meirom, Roi A.; Romasco, Amber L.; Clark, Trevor; Muhlstein, Christopher L.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA.
   [Alsem, Daan Hem; Dubey, Madan; Ritchie, Robert O.] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Mat Sci, Berkeley, CA 94720 USA.
   [Alsem, Daan Hem] Univ Calif Berkeley, Lawrence Berkeley Lab, Natl Ctr Electron Microscopy, Berkeley, CA 94720 USA.
   [Polcawich, Ronald G.; Pulskamp, Jeffrey S.] USA, Res Lab, Adelphi, MD USA.
RP Muhlstein, CL (reprint author), Penn State Univ, Dept Mat Sci & Engn, 202B Steidle Bldg, University Pk, PA 16802 USA.
EM clm28@psu.edu
RI Ritchie, Robert/A-8066-2008
OI Ritchie, Robert/0000-0002-0501-6998
FU CAREER: Education and Research in Nanomaterial Degradation The Road to
   Molecular Fatigue Studies; NSF [NSF DMR-0449684]; US Army Research
   Office [ARO W911NF-05-1-00640]; Pennsylvania State University Materials
   Research Institute NanoFabrication Network; National Science Foundation
   [0335765, CMS-0528234]; National Nanotechnology Infrastructure Network;
   Cornell University; Director, Office of Science, Office of Basic Energy
   Sciences, Division of Materials Sciences and Engineering, of the US
   Department of Energy [DE-AC02-05CH11231]; US Department of Energy
FX Support for RAM and CLM was through "CAREER: Education and Research in
   Nanomaterial Degradation The Road to Molecular Fatigue Studies". NSF
   CAREER Award (NSF DMR-0449684) and US Army Research Office (ARO
   W911NF-05-1-00640, Program manager Dr. Bruce LaMattina). This work was
   also supported by the Pennsylvania State University Materials Research
   Institute NanoFabrication Network and the National Science Foundation
   Cooperative Agreement No. 0335765 under Contract CMS-0528234, National
   Nanotechnology Infrastructure Network, with Cornell University. Support
   for D.H.A. and R.O.R. was from the Director, Office of Science, Office
   of Basic Energy Sciences, Division of Materials Sciences and
   Engineering, of the US Department of Energy under Contract No.
   DE-AC02-05CH11231. The authors would like to thank the staff, and are
   grateful for the use of the facilities, of the National Center for
   Electron Microscopy, Lawrence Berkeley National Laboratory, which is
   supported by the US Department of Energy under the same contract number.
   The authors would like to thank Joel Martin, Brian Power, Prashant
   Ranade and Richard Piekarz for their assistance in fabrication of the Pt
   specimens.
NR 35
TC 25
Z9 25
U1 3
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
J9 ACTA MATER
JI Acta Mater.
PD FEB
PY 2011
VL 59
IS 3
BP 1141
EP 1149
DI 10.1016/j.actamat.2010.10.047
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
   Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 712TW
UT WOS:000286690100029
ER

PT J
AU Stojadinovic, A
   Nissan, A
   Eberhardt, J
   Chua, TC
   Pelz, JOW
   Esquivel, J
AF Stojadinovic, Alexander
   Nissan, Aviram
   Eberhardt, John
   Chua, Terence C.
   Pelz, Joerg O. W.
   Esquivel, Jesus
TI Development of a Bayesian Belief Network Model for Personalized
   Prognostic Risk Assessment in Colon Carcinomatosis
SO AMERICAN SURGEON
LA English
DT Article
ID LONG-TERM SURVIVAL; COLORECTAL-CANCER; PERITONEAL CARCINOMATOSIS;
   INTRAPERITONEAL CHEMOTHERAPY; PROSTATE-CANCER; NOMOGRAM; RECURRENCE;
   RESECTION; SURGERY; GENE
AB Multimodality therapy in selected patients with peritoneal carcinomatosis is gaining acceptance. Treatment-directing decision support tools are needed to individualize care and select patients best suited for cytoreductive surgery +/- hyperthermic intraperitoneal chemotherapy (CRS +/- HEPEC). The purpose of this study is to develop a predictive model that could support surgical decisions in patients with colon carcinomatosis. Fifty-three patients were enrolled in a prospective study collecting 31 clinical-pathological, treatment-related, and outcome data. The population was characterized by disease presentation, performance status, extent of peritoneal cancer (Peritoneal Cancer Index, PCI), primary tumor histology, and nodal staging. These preoperative parameters were analyzed using step-wise machine-learned Bayesian Belief Networks (BBN) to develop a predictive model for overall survival (OS) in patients considered for CRS +/- HIPEC. Area-under-the-curve from receiver-operating-characteristics curves of OS predictions was calculated to determine the model's positive and negative predictive value. Model structure defined three predictors of OS: severity of symptoms (performance status), PCI, and ability to undergo CRS +/- HPEC. Patients with PCI < 10, resectable disease, and excellent performance status who underwent CRS HIPEC had 89 per cent probability of survival compared with 4 per cent for those with poor performance status, PCI > 20, who were not considered surgical candidates. Cross validation of the BBN model robustly classified OS (area-under-the-curve = 0.71). The model's positive predictive value and negative predictive value are 63.3 per cent and 68.3 per cent, respectively. This exploratory study supports the utility of Bayesian classification for developing decision support tools, which assess case-specific relative risk for a given patient for oncological outcomes based on clinically relevant classifiers of survival. Further prospective studies to validate the BBN model-derived prognostic assessment tool are warranted.
C1 [Stojadinovic, Alexander; Nissan, Aviram; Esquivel, Jesus] US Mil Canc Inst, Washington, DC 20307 USA.
   [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA.
   [Nissan, Aviram] Hadassah Hebrew Univ Med Ctr, Dept Surg, Div Surg Oncol, Jerusalem, Israel.
   [Eberhardt, John] DecisionQ Corp, Washington, DC USA.
   [Chua, Terence C.] Univ New S Wales, Dept Surg, St George Hosp, Sydney, NSW, Australia.
   [Pelz, Joerg O. W.] Univ Wurzburg, Dept Surg, D-97070 Wurzburg, Germany.
   [Esquivel, Jesus] St Agnes Hosp, Dept Surg, Peritoneal Surface Malignancy Program, Baltimore, MD USA.
RP Stojadinovic, A (reprint author), US Mil Canc Inst, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA.
EM alexander.stojadinovic@amedd.army.mil
NR 20
TC 11
Z9 12
U1 1
U2 6
PU SOUTHEASTERN SURGICAL CONGRESS
PI ATLANTA
PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA
SN 0003-1348
J9 AM SURGEON
JI Am. Surg.
PD FEB
PY 2011
VL 77
IS 2
BP 221
EP 230
PG 10
WC Surgery
SC Surgery
GA 716XB
UT WOS:000287005700018
PM 21337884
ER

PT J
AU Gribok, AV
   Chen, XX
   Reifman, J
AF Gribok, Andrei V.
   Chen, Xiaoxiao
   Reifman, Jaques
TI A Robust Method to Estimate Instantaneous Heart Rate from Noisy
   Electrocardiogram Waveforms
SO ANNALS OF BIOMEDICAL ENGINEERING
LA English
DT Article
DE Heart rate estimation; Least squares; Regularization; Confidence
   intervals
ID QRS DETECTION ALGORITHMS; RATE TIME-SERIES; RESPIRATORY RATE;
   RATE-VARIABILITY; ECG
AB We propose a new algorithm for real-time estimation of instantaneous heart rate (HR) from noise-laden electrocardiogram (ECG) waveforms typical of unstructured, ambulatory field environments. The estimation of HR from ECG waveforms is an indirect measurement problem that requires differencing, which invariably amplifies high-frequency noise. We circumvented noise amplification by considering the estimation of HR as the solution of a weighted regularized least squares problem, which, in addition, directly provided analytically based confidence intervals (CIs) for the estimated HRs. To evaluate the performance of the proposed algorithm, we applied it to simulated data and to noise-laden ECG records that were collected during helicopter transport of trauma-injured patients to a trauma center. We compared the proposed algorithm with HR estimates produced by a widely used vital-sign travel monitor and a standard HR estimation technique, followed by postprocessing with Kalman filtering or spline smoothing. The simulation results indicated that our algorithm consistently produced more accurate HR estimates, with estimation errors as much as 67% smaller than those attained by the postprocessing methods, while the results with the field-collected data showed that the proposed algorithm produced much smoother and reliable HR estimates than those obtained by the vital-sign monitor. Moreover, the obtained CIs reflected the amount of noise in the ECG recording and could be used to statistically quantify uncertainties in the HR estimates. We conclude that the proposed method is robust to different types of noise and is particularly suitable for use in ambulatory environments where data quality is notoriously poor.
C1 [Gribok, Andrei V.; Chen, Xiaoxiao; Reifman, Jaques] USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, Med Res & Mat Command, ATTN MCMR TT, Ft Detrick, MD 21702 USA.
   [Gribok, Andrei V.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA.
RP Reifman, J (reprint author), USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, Med Res & Mat Command, ATTN MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman@us.army.mil
FU War Supplemental competitive grant
FX We thank Y. Lu, S. Rajaraman, and C. Meng for providing stimulating
   feedback. This study was supported by a War Supplemental competitive
   grant managed by the Combat Casualty Care Directorate of the U S. Army
   Medical Research and Materiel Command, Fort Detrick, MD.
NR 31
TC 4
Z9 5
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-6964
EI 1573-9686
J9 ANN BIOMED ENG
JI Ann. Biomed. Eng.
PD FEB
PY 2011
VL 39
IS 2
BP 824
EP 834
DI 10.1007/s10439-010-0204-2
PG 11
WC Engineering, Biomedical
SC Engineering
GA 719OD
UT WOS:000287213300019
PM 21103932
ER

PT J
AU Summers, SM
AF Summers, Shane Michael
TI Personal Experience and Reflections on Providing Health Care for
   Detainees in Support of Operation Iraqi Freedom
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Editorial Material
C1 Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA.
RP Summers, SM (reprint author), Brooke Army Med Ctr, Dept Emergency Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM shanemsummers@yahoo.com
NR 3
TC 0
Z9 0
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD FEB
PY 2011
VL 57
IS 2
BP 172
EP 173
DI 10.1016/j.annemergmed.2010.03.009
PG 2
WC Emergency Medicine
SC Emergency Medicine
GA 722WB
UT WOS:000287464900021
PM 21251526
ER

PT J
AU Crabtree, SJ
   Robertson, JL
   Chung, KK
   Renz, EM
   Wolf, SE
   Hospenthal, DR
   Murray, CK
AF Crabtree, Scott J.
   Robertson, Janelle L.
   Chung, Kevin K.
   Renz, Evan M.
   Wolf, Steven E.
   Hospenthal, Duane R.
   Murray, Clinton K.
TI Clostridium difficile infections in patients with severe burns
SO BURNS
LA English
DT Article
DE Burn; Diarrhea; Clostridium difficile; Clostridial; Colitis
ID DISEASE; CARE; ICU; DIARRHEA; SEPSIS
AB With improved survival in burn patients, Clostridium difficile infection (CDI) remains a significant potential complication. The incidence of, risk factors for, and outcomes of CDI in severely burned patients are poorly studied and remain unclear. This study involves retrospective case control and cohort studies using electronic medical records from February 1, 2002 to January 31, 2009 at the US Department of Defense's only burn unit. Demographic, risk factor, and outcome data were collected for all C. difficile toxin positive patients in the burn, medical, and surgical intensive care units and the hospital's step down unit along with an additional analysis of a 2:1 matched control of C. difficile toxin negative to positive burn patients. In the burn intensive care unit (BICU) population there was an incidence of 7.9 cases per 10,000 patient days; less than the non-burn unit rate of 15.2 cases (p-value < 0.01). The BICU patients were young males with a median 42% total body surface area burns. There were higher frequencies of operations and prior aminoglycoside use, with longer unit stays and times until death or discharge. There was no difference in treatments, morbidity, or mortality. The comparison of patients with positive and negative C. difficile toxin among those in the BICU revealed few significant differences in risk factors or outcomes. Differences in risk factors between burn and non-burn patients were likely markers of the populations rather than independent risk factors for CDI in the burn population with overall lower rates likely reflective of younger, healthier patients in the BICU and more aggressive infection control practices. Published by Elsevier Ltd and ISBI
C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA.
   [Robertson, Janelle L.; Renz, Evan M.; Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Chung, Kevin K.; Renz, Evan M.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Wolf, Steven E.; Hospenthal, Duane R.; Murray, Clinton K.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Clinton.Murray@amedd.army.mil
OI Wolf, Steven/0000-0003-2972-3440
NR 16
TC 7
Z9 7
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
J9 BURNS
JI Burns
PD FEB
PY 2011
VL 37
IS 1
BP 42
EP 48
DI 10.1016/j.burns.2010.06.008
PG 7
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA 717UL
UT WOS:000287072800005
PM 21050662
ER

PT J
AU Zhou, J
   Enewold, L
   Zahm, SH
   Devesa, SS
   Anderson, WF
   Potter, JF
   McGlynn, KA
   Zhu, KM
AF Zhou, Jing
   Enewold, Lindsey
   Zahm, Shelia H.
   Devesa, Susan S.
   Anderson, William F.
   Potter, John F.
   McGlynn, Katherine A.
   Zhu, Kangmin
TI Melanoma Incidence Rates among Whites in the U.S. Military
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID NONMELANOMA SKIN-CANCER; VITAMIN-D; CUTANEOUS MELANOMA;
   MALIGNANT-MELANOMA; SUN PROTECTION; UNITED-STATES; TANNING BEDS;
   RISK-FACTORS; EPIDEMIOLOGY; PREVENTION
AB Background: The U. S. Military and general populations may differ in the exposure to sunlight and other risk factors for melanoma and therefore the incidence rates of melanoma may be different in these two populations. However, few studies have compared melanoma incidence rates and trends over time between the military and the general population.
   Methods: Melanoma incidence rates from 1990 to 2004 among white active-duty military personnel and the general U. S. population were compared using data from the Department of Defense Automated Central Tumor Registry and the National Cancer Institute Surveillance, Epidemiology, and End Results program.
   Results: Age-adjusted melanoma rates overall were significantly lower in the military than in the general population; the incidence rate ratio was 0.75 for men and 0.56 for women. Age-specific rates, however, were significantly lower among individuals younger than 45 years, but significantly higher among those 45 years or older (P < 0.05). Melanoma incidence increased from 1990-1994 to 2000-2004 in both populations, with the most rapid increase (40%) among younger men in the military. Melanoma incidence rates also varied by branch of military service; rates were highest in the air force.
   Conclusion: These results suggest that melanoma incidence rate patterns differ between the military and the general population.
   Impact: Further studies of risk factors for melanoma in the military are needed to explain these findings. Cancer Epidemiol Biomarkers Prev; 20(2); 318-23. (C)2010 AACR.
C1 [Zhou, Jing; Enewold, Lindsey; Potter, John F.; Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA.
   [Zahm, Shelia H.; Devesa, Susan S.; Anderson, William F.; McGlynn, Katherine A.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
   [Potter, John F.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Zhu, KM (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Bldg 1,Suite A-109,6900 Georgia Ave NW, Washington, DC 20307 USA.
EM Kangmin.zhu@amedd.army.mil
RI Zahm, Shelia/B-5025-2015
FU United States Military Cancer Institute via the Uniformed Services
   University of the Health Sciences under the auspices of the Henry M.
   Jackson Foundation for the Advancement of Military Medicine; Division of
   Cancer Epidemiology and Genetics (DCEG), National Cancer Institute
FX This research was supported by the United States Military Cancer
   Institute via the Uniformed Services University of the Health Sciences
   under the auspices of the Henry M. Jackson Foundation for the
   Advancement of Military Medicine and by the Division of Cancer
   Epidemiology and Genetics (DCEG), National Cancer Institute.
NR 44
TC 4
Z9 5
U1 0
U2 8
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD FEB
PY 2011
VL 20
IS 2
BP 318
EP 323
DI 10.1158/1055-9965.EPI-10-0869
PG 6
WC Oncology; Public, Environmental & Occupational Health
SC Oncology; Public, Environmental & Occupational Health
GA 717CU
UT WOS:000287021400014
PM 21148122
ER

PT J
AU Kuhnle, MD
   Ryan, DS
   Coe, CD
   Eaddy, J
   Kuzmowych, C
   Edwards, J
   Howard, RS
   Bower, KS
AF Kuhnle, Matthew D.
   Ryan, Denise S.
   Coe, Charles D.
   Eaddy, Jennifer
   Kuzmowych, Chrystyna
   Edwards, Jayson
   Howard, Robin S.
   Bower, Kraig S.
TI Oral gabapentin for photorefractive keratectomy pain
SO JOURNAL OF CATARACT AND REFRACTIVE SURGERY
LA English
DT Article
ID VISUAL ANALOG SCALE; POSTOPERATIVE PAIN; HERPES-ZOSTER; 0.1-PERCENT
AB PURPOSE: To compare the efficacy of oral gabapentin versus placebo for the control of severe pain after photorefractive keratectomy (PRK).
   SETTING: Center for Refractive Surgery, Walter Reed Army Medical Center, Washington, DC, USA.
   DESIGN: Randomized masked clinical trial.
   METHODS: This single-center clinical trial comprised active-duty United States Army soldiers aged 21 years or older having bilateral PRK for myopia with or without astigmatism. Patients received gabapentin 300 mg or placebo 3 times daily for 7 days beginning 2 days before and continuing for 4 days after surgery. Current and maximum pain levels were assessed using the Visual Analog Pain scale 2 hours after surgery and then daily on days 1 through 4. Repeated-measures analysis of variance (ANOVA) was used to compare the current and maximum pain scores over time between the gabapentin group and the placebo group. The Fisher exact test was used to determine whether there was a difference in severe pain (>7/10) between the 2 groups.
   RESULTS: Forty-two patients received gabapentin and 41 patients, placebo. The repeated-measures ANOVA showed no significant difference between the 2 groups in current pain (P=.84) or in maximum pain over time (P=.35). Oxycodone acetaminophen use in the gabapentin group was significantly higher than in the placebo group 1 day postoperatively (P=.034).
   CONCLUSION: When added to a standardized postoperative pain regimen, gabapentin use led to no additional improvement in PRK pain control compared with a placebo at the dose and the time intervals tested.
C1 [Kuhnle, Matthew D.; Ryan, Denise S.; Coe, Charles D.; Eaddy, Jennifer; Kuzmowych, Chrystyna; Bower, Kraig S.] Walter Reed Army Med Ctr, Ctr Refract Surg, Washington, DC 20307 USA.
   [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Biostat Serv, Washington, DC 20307 USA.
   [Edwards, Jayson] Univ Florida, Coll Med, Dept Ophthalmol, Jacksonville, FL USA.
RP Kuhnle, MD (reprint author), Carl R Darnall Army Med Ctr, Ophthalmol Serv, 36000 Darnall Loop, Ft Hood, TX 76544 USA.
EM matthew.kuhnle@us.army.mil
NR 22
TC 9
Z9 10
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0886-3350
J9 J CATARACT REFR SURG
JI J. Cataract. Refract. Surg.
PD FEB
PY 2011
VL 37
IS 2
BP 364
EP 369
DI 10.1016/j.jcrs.2010.08.041
PG 6
WC Ophthalmology; Surgery
SC Ophthalmology; Surgery
GA 716FE
UT WOS:000286953700023
PM 21241922
ER

PT J
AU Teyhen, DS
   Stoltenberg, BE
   Eckard, TG
   Doyle, PM
   Boland, DM
   Feldtmann, JJ
   McPoil, T
   Christie, DS
   Molloy, JM
   Goffar, SL
AF Teyhen, Deydre S.
   Stoltenberg, Brian E.
   Eckard, Timothy G.
   Doyle, Peter M.
   Boland, David M.
   Feldtmann, Jess J.
   McPoil, Thomas
   Christie, Douglas S.
   Molloy, Joseph M.
   Goffar, Stephen L.
TI Static Foot Posture Associated With Dynamic Plantar Pressure Parameters
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE anthropometrics; arch height; foot; foot posture index; podography
ID ARCH HEIGHT INDEX; OVERUSE INJURY; RISK-FACTORS; RELIABILITY; PATTERNS;
   RUNNERS; SYSTEM; PAIN; VALIDATION; MORPHOLOGY
AB STUDY DESIGN: Controlled laboratory study.
   OBJECTIVE: To explore potential associations between foot posture index (FPI-6) composite scores and dynamic plantar pressure measurements, and to describe each of the 6 subscales and the FPI-6 composite scores across our sample.
   BACKGROUND: The FPI-6 is a static foot posture assessment comprised of 6 observations. Extreme scores have been associated with increased injury risk. However, knowledge describing the relationship between FPI-6 scores and plantar pressure distributions during gait is limited.
   METHODS: Participants (n = 1000:566 males, 434 females) were predominantly active adults (mean +/- SD age, 30.6 +/- 8.0 years; body mass index, 26.2 +/- 3.7 kg/m(2)), who ran 3.1 +/- 1.4 d/wk. Static and dynamic foot characteristics were compared using the FPI-6 and a capacitance-based pressure platform. Correlation and hierarchical stepwise regression analyses were performed to determine the most parsimonious set of dynamic pressure data associated with FPI-6 scores.
   RESULTS: The mean +/- SD FPI-6 score was 3.4 +/- 2.9 (range, -6.0 to 11.0). Only 31 participants received a score of -2 (supinated foot) on any FPI-6 subscale. Classification of a pronated foot was 2.4 times more likely than a supinated foot. A 5-variable model (R = 0.57, R(2) = 0.32) was developed to describe the association between dynamic plantar pressures and FPI-6 scores.
   CONCLUSION: The multivariate model associated with FPI-6 scores comprised clinically plausible variables which inform the association between static and dynamic foot postures. Different cutoff values may be required when using the FPI-6 to screen for individuals with supinated feet, given the limited number of high-arched participants identified by FPI-6 classifications. J Orthop Sports Phys Ther 2011;41(2):100-107, Epub 22 October 2010. doi:10.2519/jospt.2011.3412
C1 [Teyhen, Deydre S.; Christie, Douglas S.; Goffar, Stephen L.] USA, Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX USA.
   [Teyhen, Deydre S.] Ctr Phys Therapy Res, San Antonio, TX USA.
   [Stoltenberg, Brian E.] Irwin Army Community Hosp, Ft Riley, KS USA.
   [Eckard, Timothy G.] Madigan Army Med Ctr, Ft Lewis, WA USA.
   [Doyle, Peter M.; Boland, David M.] DeWitt Army Community Hosp, Ft Belvoir, VA USA.
   [Feldtmann, Jess J.] Phys Therapy Serv, Sinai, Egypt.
   [McPoil, Thomas] Regis Univ, Denver, CO USA.
   [Molloy, Joseph M.] Brooke Army Med Ctr, Phys Therapy Serv, San Antonio, TX USA.
RP Teyhen, DS (reprint author), USA, Med Dept Ctr & Sch, Dept Phys Therapy, 3150 Stanley Rd,Room 1303,ATTN MCCS HGE PT, Ft Sam Houston, TX 78234 USA.
EM deydre.teyhen@amedd.army.mil
FU Office of the Assistant Secretary of the Amy (Installations and
   Environmental); National Dense Center for Energy and Environment (NDCEE)
   [W74V8H-04-D-0005]
FX We thank Keith M Collinsworth, Crystal L. Giesel, Drew G. Williams, and
   Cyrus H. Kardouni for their time and contributions to this study. This
   work was funded through the Office of the Assistant Secretary of the Amy
   (Installations and Environmental) and the National Dense Center for
   Energy and Environment (NDCEE), and conducted under contract
   W74V8H-04-D-0005 Task 0427
NR 41
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U1 4
U2 24
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD FEB
PY 2011
VL 41
IS 2
BP 100
EP 107
DI 10.2519/jospt.2011.3412
PG 8
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 718ZG
UT WOS:000287164600009
PM 20972342
ER

PT J
AU Molloy, JM
   Paschall, JC
   Bui-Mansfield, LT
AF Molloy, Joseph M.
   Paschall, Jeffrey C.
   Bui-Mansfield, Liem T.
TI Acromioclavicular Joint Synovial Chondromatosis
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Molloy, Joseph M.] USA, Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
   [Bui-Mansfield, Liem T.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA.
   [Paschall, Jeffrey C.] Blanchfield Army Community Hosp, Ft Campbell, KY USA.
RP Molloy, JM (reprint author), USA, Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD FEB
PY 2011
VL 41
IS 2
BP 118
EP 118
DI 10.2519/jospt.2011.0403
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 718ZG
UT WOS:000287164600011
PM 21285526
ER

PT J
AU Hair, LC
   Deyle, G
AF Hair, Leslie C.
   Deyle, Gail
TI Eosinophilic Granuloma in a Patient With Hip Pain
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Hair, Leslie C.] USN, Special Warfare Grp 4, Virginia Beach, VA USA.
   [Deyle, Gail] Baylor Univ, Grad Sch, Ft Sam Houston, TX USA.
   [Deyle, Gail] Army Baylor Univ, Ft Sam Houston, TX USA.
   [Deyle, Gail] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Hair, LC (reprint author), USN, Special Warfare Grp 4, Virginia Beach, VA USA.
NR 0
TC 1
Z9 1
U1 0
U2 1
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD FEB
PY 2011
VL 41
IS 2
BP 119
EP 119
DI 10.2519/jospt.2011.0404
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA 718ZG
UT WOS:000287164600012
PM 21285527
ER

PT J
AU Fridman, M
   Nixon, M
   Dubinskii, M
   Friesem, AA
   Davidson, N
AF Fridman, Moti
   Nixon, Micha
   Dubinskii, Mark
   Friesem, Asher A.
   Davidson, Nir
TI Principal modes in fiber amplifiers
SO OPTICS LETTERS
LA English
DT Article
ID POLARIZATION DISPERSION; SINGLE-MODE; CLAD FIBER; BIREFRINGENCE;
   TEMPERATURE; STATES; CABLE
AB The dynamics of the state of polarization in multimode fiber amplifiers is presented. The experimental results reveal that although the state of polarizations at the output can vary over a large range when changing the temperatures of the fiber amplifiers, the variations are significantly reduced when resorting to the principal states of polarization in single-mode fiber amplifiers and principal modes in multimode fiber amplifiers. (C) 2011 Optical Society of America
C1 [Fridman, Moti; Nixon, Micha; Friesem, Asher A.; Davidson, Nir] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel.
   [Dubinskii, Mark] USA, Res Lab, Adelphi, MD 20783 USA.
RP Fridman, M (reprint author), Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel.
EM moti.fridman@weizmann.ac.il
NR 18
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Z9 2
U1 0
U2 2
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
J9 OPT LETT
JI Opt. Lett.
PD FEB 1
PY 2011
VL 36
IS 3
BP 388
EP 390
DI 10.1364/OL.36.000388
PG 3
WC Optics
SC Optics
GA 713HO
UT WOS:000286726900027
PM 21283199
ER

PT J
AU Perkins, JG
   Cap, AP
   Spinella, PC
   Shorr, AF
   Beekley, AC
   Grathwohl, KW
   Rentas, FJ
   Wade, CE
   Holcomb, JB
AF Perkins, Jeremy G.
   Cap, Andrew P.
   Spinella, Philip C.
   Shorr, Andrew F.
   Beekley, Alec C.
   Grathwohl, Kurt W.
   Rentas, Francisco J.
   Wade, Charles E.
   Holcomb, John B.
CA 31st Combat Support Hosp Res Grp
TI Comparison of platelet transfusion as fresh whole blood versus apheresis
   platelets for massively transfused combat trauma patients (CME)
SO TRANSFUSION
LA English
DT Article
ID LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL HEMATOLOGY; RED-CELL
   STORAGE; FROZEN PLASMA; IMPROVED SURVIVAL; EXSANGUINATION PROTOCOL;
   CARDIOPULMONARY BYPASS; PRODUCT UTILIZATION; CARDIAC OPERATIONS; IMPACT
AB BACKGROUND:
   At major combat hospitals, the military is able to provide blood products to include apheresis platelets (aPLT), but also has extensive experience using fresh whole blood (FWB). In massively transfused trauma patients, we compared outcomes of patients receiving FWB to those receiving aPLT.
   STUDY DESIGN AND METHODS:
   This study was a retrospective review of casualties at the military hospital in Baghdad, Iraq, between January 2004 and December 2006. Patients requiring massive transfusion (>= 10 units in 24 hr) were divided into two groups: those receiving FWB (n = 85) or aPLT (n = 284) during their resuscitation. Admission characteristics, resuscitation, and survival were compared between groups. Multivariate regression analyses were performed comparing survival of patients at 24 hours and at 30 days. Secondary outcomes including adverse events and causes of death were analyzed.
   RESULTS:
   Unadjusted survival between groups receiving aPLT and FWB was similar at 24 hours (84% vs. 81%, respectively; p = 0.52) and at 30 days (60% versus 57%, respectively; p = 0.72). Multivariate regression failed to identify differences in survival between patients receiving PLT transfusions either as FWB or as aPLT at 24 hours or at 30 days.
   CONCLUSIONS:
   Survival for massively transfused trauma patients receiving FWB appears to be similar to patients resuscitated with aPLT. Prospective trials will be necessary before consideration of FWB in the routine management of civilian trauma. However, in austere environments where standard blood products are unavailable, FWB is a feasible alternative.
C1 [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
   USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   Connecticut Childrens Med Ctr, Hartford, CT USA.
   Washington Hosp Ctr, Washington, DC 20010 USA.
   Madigan Army Med Ctr, Tacoma, WA 98431 USA.
   Brooke Army Med Ctr, San Antonio, TX USA.
   Armed Serv Blood Program Off, Falls Church, VA USA.
   Univ Texas Hlth Sci Ctr, Houston, TX USA.
RP Perkins, JG (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM Jeremy.perkins1@us.army.mil
NR 61
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U1 1
U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0041-1132
J9 TRANSFUSION
JI Transfusion
PD FEB
PY 2011
VL 51
IS 2
BP 242
EP 252
DI 10.1111/j.1537-2995.2010.02818.x
PG 11
WC Hematology
SC Hematology
GA 719IW
UT WOS:000287199400004
PM 20796254
ER

PT J
AU Musser, JE
   Ernest, AJ
   Thibault, GP
   McMann, LP
AF Musser, John E.
   Ernest, Alexander J.
   Thibault, Gregory P.
   McMann, Leah P.
TI Primary Adenocarcinoma of the Rete Testis: Improved Staging Accuracy
   With CT-PET
SO UROLOGY
LA English
DT Editorial Material
C1 [Musser, John E.] Tripler Army Med Ctr, Dept Surg, Urol Sect, Honolulu, HI 96859 USA.
RP Musser, JE (reprint author), Tripler Army Med Ctr, Dept Surg, Urol Sect, Jarrett White Rd, Honolulu, HI 96859 USA.
EM john.e.musser@us.army.mil
NR 3
TC 3
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
J9 UROLOGY
JI Urology
PD FEB
PY 2011
VL 77
IS 2
DI 10.1016/j.urology.2010.02.035
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA 715XG
UT WOS:000286927700020
PM 20451971
ER

PT J
AU Rahman, KM
   El Arifeen, S
   Zaman, K
   Rahman, M
   Raqib, R
   Yunus, M
   Begum, N
   Islam, MS
   Sohel, BM
   Rahman, M
   Venkatesan, M
   Hale, TL
   Isenbarger, DW
   Sansonetti, PJ
   Black, RE
   Baqui, AH
AF Rahman, Kazi Mizanur
   El Arifeen, Shams
   Zaman, K.
   Rahman, Mahbubur
   Raqib, Rubhana
   Yunus, Mohammad
   Begum, Nazma
   Islam, Md. Shaheenul
   Sohel, Badrul Munir
   Rahman, Muntasirur
   Venkatesan, Malabi
   Hale, Thomas L.
   Isenbarger, Daniel W.
   Sansonetti, Philippe J.
   Black, Robert E.
   Baqui, Abdullah H.
TI Safety, dose, immunogenicity, and transmissibility of an oral live
   attenuated Shigella flexneri 2a vaccine candidate (SC602) among healthy
   adults and school children in Matlab, Bangladesh
SO VACCINE
LA English
DT Article
DE Shigella vaccine; SC602; Randomized controlled trial; Bangladesh
ID CHOLERA VACCINE; VOLUNTEERS; DIARRHEA; BURDEN
AB In double-blind trials in Bangladesh, 88 adults, and 79 children (8-10 years) were randomized to receive either a single oral dose of 1 x 10(4), 1 x 10(5) or 1 x 10(6) CFU of SC602 (a live, attenuated Shigella flexneri 2a strain vaccine) or placebo. In the adult outpatient 1 x 10(6) CFU group, severe joint pain and body aches were reported by one and two vaccinees respectively. In the adult inpatient trial, SC602 was isolated from 3 volunteers, pre-vaccination antibody titers were high, and fourfold increases in serum IgG anti-LPS responses were observed in 2 of 5 subjects of the 1 x 10(6) CFU group. None of the volunteers developed diarrhea. Overall, SC602 was found to be associated with minimal vaccine shedding, minimal reactogenicity, no transmission risk, and low immune stimulation. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Rahman, Kazi Mizanur] ICDDR B, Div Publ Hlth Sci, Child Hlth Unit, Dhaka 1212, Bangladesh.
   [Black, Robert E.; Baqui, Abdullah H.] JHU, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
   [Venkatesan, Malabi; Hale, Thomas L.; Isenbarger, Daniel W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
   [Sansonetti, Philippe J.] Inst Pasteur, INSERM, U786, Unite Pathogenie Microbienne Mol, F-75724 Paris 15, France.
RP Rahman, KM (reprint author), ICDDR B, Div Publ Hlth Sci, Child Hlth Unit, 68 Shaheed Tajuddin Ahmed Sarani, Dhaka 1212, Bangladesh.
EM mizan@icddrb.org
OI Black, Robert/0000-0001-9926-7984; Raqib, Rubhana/0000-0002-8116-4511
FU Walter Reed Army Institute of Research (WRAIR), USA; National Vaccine
   Program (NVP), USA
FX This research study was funded by Walter Reed Army Institute of Research
   (WRAIR), USA and National Vaccine Program (NVP), USA. The opinions or
   assertions contained herein are the private views of the authors, and
   are not to be construed as official, or as reflecting true views of the
   Department of the Army or the Department of Defense. The authors are
   grateful to Dr. David Taylor for his comments and suggestions. ICDDR,B
   acknowledges with gratitude the commitment of WRAIR and NVP to the
   Centre's research efforts.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD FEB 1
PY 2011
VL 29
IS 6
BP 1347
EP 1354
DI 10.1016/j.vaccine.2010.10.035
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 721FU
UT WOS:000287339800034
PM 21040694
ER

PT J
AU Nyakatawa, EZ
   Mays, DA
   Britton, R
   Pacumbaba, RO
   Howard, HR
   Svendsen, NG
AF Nyakatawa, Ermson Z.
   Mays, David A.
   Britton, Rhonda
   Pacumbaba, Rudolfo O., Jr.
   Howard, H. R.
   Svendsen, N. G.
TI Nitrogen and phosphorus transport in runoff from compost berms on a
   simulated military training landscape
SO WASTE MANAGEMENT & RESEARCH
LA English
DT Article
DE Ammonium N; land degradation; nitrate N; orthophosphate; soil erosion;
   total dissolved solids
ID MUNICIPAL SOLID-WASTE; CENTRAL NEGEV; VEGETATION; SOIL; ENVIRONMENT;
   PATTERNS; IMPACTS; EROSION; LOSSES; ISRAEL
AB Compost mulches have potential to significantly offset on-and off-site environmental impacts resulting from mechanical soil disturbances and training manoeuvres on military training ranges. N and P transport was investigated in runoff from compost mulch berms made from various organic waste materials in combination with each other and with soil on a simulated military training landscape in north Alabama in 2007 and 2008. Berms were constructed using composted municipal yard waste (YW), wood chips (WC), pine bark fines (PB), and soil (SL) mixed in eight different proportions. Berms made from 100% soil which had a cumulative runoff PO4-P content of 12 mg L(-1) posed the greatest threat of negatively impacting the environment from inorganic P transport. Using compost mulch material with 40% soil to build berms reduced the potential for yard waste and wood chips to cause off-site negative environmental impacts from total dissolved solids, N, and P transport. Berms made from 100% pine bark fines which had cumulative runoff values of 760, 9, 22 and 5mg L(-1), respectively, of TDS, NH(4)-N, NO(3)-N, and PO(4)-P had the least potential to cause negative off-site environmental impact. To prevent negative impacts of nutrient transport in runoff from berms on training landscapes, the sites need to be well buffered to hydrologically isolate them from adjoining ecosystems.
C1 [Nyakatawa, Ermson Z.; Mays, David A.; Britton, Rhonda; Pacumbaba, Rudolfo O., Jr.] Alabama A&M Univ, Dept Nat Resources & Environm Sci, Normal, AL 35762 USA.
   [Howard, H. R.; Svendsen, N. G.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA.
RP Nyakatawa, EZ (reprint author), Alabama A&M Univ, Dept Nat Resources & Environm Sci, POB 1208, Normal, AL 35762 USA.
EM ermson.nyakatawa@aamu.edu
FU US Army, Engineer Research and Development Center - Construction
   Engineering Research Laboratory (ERDC -CERL), Champaign, Illinois, USA
   [COE-W9132T 06 R 0018]
FX This work was supported by the US Army, Engineer Research and
   Development Center - Construction Engineering Research Laboratory (ERDC
   -CERL), Champaign, Illinois, USA [Contract number COE-W9132T 06 R 0018].
NR 27
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U1 1
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0734-242X
J9 WASTE MANAGE RES
JI Waste Manage. Res.
PD FEB
PY 2011
VL 29
IS 2
BP 188
EP 196
DI 10.1177/0734242X10368304
PG 9
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 717DB
UT WOS:000287022200009
PM 20406749
ER

PT J
AU Guicheteau, J
   Christesen, S
   Emge, D
   Wilcox, P
   Fountain, AW
AF Guicheteau, Jason
   Christesen, Steven
   Emge, Darren
   Wilcox, Phillip
   Fountain, Augustus W., III
TI Assessing Metal Nanofabricated Substrates for Surface-Enhanced Raman
   Scattering (SERS) Activity and Reproducibility
SO APPLIED SPECTROSCOPY
LA English
DT Article
DE Surface-enhanced Raman spectroscopy; SERS; Nanoparticle substrates;
   Raman spectroscopy; Reproducibility; Spectral discrimination;
   Standardized testing protocols; Substrate performance
ID SILVER ELECTRODE; SINGLE-MOLECULE; SPECTROSCOPY; SENSITIVITY
AB Surface-enhanced Raman spectroscopy (SERS) has been shown to be an effective technique for increasing the detection sensitivity in chemical and biological applications. SERS has a distinct advantage over normal Raman spectroscopy, with enhancements typically greater than 10(4) over the normal Raman signal; however, this advantage in sensitivity comes with a caveat: controlling the spectroscopic reproducibility and enhancement activity of metal nanostructured substrates can be difficult. We present a survey and subsequent data analysis performed on several nanostructured substrates designed for SEAS, including silver and gold colloids, silver nanorods, gold nanoshells, and commercially manufactured gold nanostructures.
C1 [Guicheteau, Jason; Christesen, Steven; Emge, Darren; Wilcox, Phillip; Fountain, Augustus W., III] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
RP Fountain, AW (reprint author), USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA.
EM augustus.w.fountain@us.army.mil
NR 29
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U1 0
U2 16
PU SOC APPLIED SPECTROSCOPY
PI FREDERICK
PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA
SN 0003-7028
J9 APPL SPECTROSC
JI Appl. Spectrosc.
PD FEB
PY 2011
VL 65
IS 2
BP 144
EP 151
DI 10.1366/10-06080
PG 8
WC Instruments & Instrumentation; Spectroscopy
SC Instruments & Instrumentation; Spectroscopy
GA 710XE
UT WOS:000286549500003
ER

PT J
AU Holmes, JP
   Clifton, GT
   Patil, R
   Benavides, LC
   Gates, JD
   Stojadinovic, A
   Mittendorf, EA
   Ponniah, S
   Peoples, GE
AF Holmes, Jarrod P.
   Clifton, Guy T.
   Patil, Ritesh
   Benavides, Linda C.
   Gates, Jeremy D.
   Stojadinovic, Alexander
   Mittendorf, Elizabeth A.
   Ponniah, Sathibalan
   Peoples, George E.
TI Use of Booster Inoculations to Sustain the Clinical Effect of an
   Adjuvant Breast Cancer Vaccine From US Military Cancer Institute
   Clinical Trials Group Study I-01 and I-02
SO CANCER
LA English
DT Article
DE breast cancer; HER-2/neu peptide vaccine; E75; booster
ID T-CELL MEMORY; COLONY-STIMULATING FACTOR; HER2/NEU E75 VACCINE; PHASE-II
   TRIAL; ANTITUMOR IMMUNITY; MELANOMA VACCINE; PEPTIDE VACCINE; DENDRITIC
   CELLS; OVARIAN-CANCER; IN-VIVO
AB BACKGROUND: The authors are conducting clinical trials of the HER-2/neu E75-peptide vaccine in clinically disease-free breast cancer (BC) patients. Their phase 1-2 trials revealed that the E75 + granulocyte-macrophage colony-stimulating factor (GM-CSF) vaccine is safe and effective in stimulating clonal expansion of E75-specific CD8(+) T cells. They assessed the need for and response to a booster after completion of primary vaccination series. METHODS: BC patients enrolled in the E75 vaccine trials who were >= 6 months from completion of their primary vaccination series were offered boosters with E75 + GM-CSF. Patients were monitored for toxicity. E75-specific CD8(+) T cells were quantified using the human leukocyte antigen-A2: immunoglobulin G dimer before and after boosting. RESULTS: Fifty-three patients received the vaccine booster. Median time from primary vaccination series was 9 months (range, 6-35 months), and median residual E75-specific immunity was 0.70% (range, 0-3.49%) CD8(+) lymphocytes. Elevated residual immunity (ERI) (CD8(+) E75-specific T cells >0.5%) was seen in 94.4% of patients at 6 months from primary vaccination series versus 48% of patients at >6 months (P = .002). The booster was well tolerated, with only grade 1 and 2 toxicity observed. Local reactions were more robust in patients receiving the booster at 6 months from primary vaccination series compared with those at >6 months (99.4 +/- 6.1 mm vs 81.8 +/- 4.1 mm, P = .01). In patients lacking ERI, 85% had increased ERI after vaccination (P = .0014). CONCLUSIONS: The HER-2/neu E75 peptide vaccine E75 stimulates specific immunity in disease-free BC patients. However, immunity wanes with time. A vaccine booster is safe and effective in stimulating E75-specific immunity in those patients without ERI. These results suggest that the booster may be most effective at 6 months after completion of the primary vaccination series. Cancer 2011;117:463-71. Published 2010 by the American Cancer Society.*
C1 [Clifton, Guy T.; Benavides, Linda C.; Gates, Jeremy D.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA.
   [Holmes, Jarrod P.] USN, Dept Hematol & Med Oncol, San Diego Med Ctr, San Diego, CA 92152 USA.
   [Patil, Ritesh] Joyce Murtha Breast Canc Ctr, Windber, PA USA.
   [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
   [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
   [Ponniah, Sathibalan; Peoples, George E.] US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD USA.
   [Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM george.peoples@amedd.army.mil
FU United States Military Cancer Institute, Department of Surgery,
   Uniformed Services University of the Health Sciences; Department of
   Clinical Investigation, Walter Reed Army Medical Center
FX Supported by the United States Military Cancer Institute, Department of
   Surgery, Uniformed Services University of the Health Sciences, and the
   Department of Clinical Investigation, Walter Reed Army Medical Center.
   Dr. Peoples has inventor rights. The E75 vaccine is licensed to Apthera,
   Inc.
NR 35
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Z9 20
U1 0
U2 4
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0008-543X
J9 CANCER-AM CANCER SOC
JI Cancer
PD FEB 1
PY 2011
VL 117
IS 3
BP 463
EP 471
DI 10.1002/cncr.25586
PG 9
WC Oncology
SC Oncology
GA 709JC
UT WOS:000286433300010
PM 20845479
ER

PT J
AU Walizer, LE
   Peters, JF
AF Walizer, Laura E.
   Peters, John F.
TI A bounding box search algorithm for DEM simulation
SO COMPUTER PHYSICS COMMUNICATIONS
LA English
DT Article
DE Algorithm theory; Contact search; Discrete element; Particle size;
   Polydisperse
ID CONTACT DETECTION ALGORITHM; SIZES
AB In Discrete Element Method (DEM) simulations, the most costly operation performed by the program in terms of CPU time is often the process of identifying which pairs of particles are potentially in contact. Program performance can especially be degraded when the relative size difference between the smallest and largest discrete elements is greater than a factor of 2 to 5. Recently, particle-based searches with a hierarchy of cell spaces were proposed to eliminate the size-dependence problem (Peters et al. (2009) [1]), He et al. (2007) PI. Both methods allowed the cell size to be based on the diameter of the smallest particles, and the methods were found to be effective. In this paper, the authors evaluate the performance of a related but simpler algorithm dubbed the 'bounding box search method'. The bounding box method entails identifying all cells which any part of a target particle may occupy, listing the target particle as present in those cells, and searching for potential contacts over the same set of cells (the 'bounding box'). Where the hierarchy methods improve performance by creating multiple cell spaces based on particle sizes, the bounding box method uses only a single cell space, but allows the cell size to be based on the smallest particles, rather than the largest. To evaluate the performance of the bounding box algorithm, timed simulations were performed on systems with varying numbers of particles and particle size distributions, and runtimes were compared to identical systems simulated using a so-called 'basic' search algorithm, which places a target particle in a single cell and searches over all neighboring cells. Results presented herein show the bounding box approach to yield improved performance relative to the simple search method for most systems, especially those with the largest numbers of particles and least uniform size distributions. The effect of selected cell size is also examined, and it is shown that cell sizes between one and two times the smallest particle diameter yielded the best performance. Published by Elsevier B.V.
C1 [Walizer, Laura E.; Peters, John F.] USA, Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Walizer, LE (reprint author), USA, Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM laura.walizer@usace.army.mil
FU DoD High Performance Computing Modernization Office; US Army Engineer
   Research and Development Center, Vicksburg, MS
FX The work described in this paper was performed as part of the software
   development under the Common High Performance Computing Software Support
   Initiative program of the DoD High Performance Computing Modernization
   Office. Permission to publish this paper was granted by the Director of
   the Geotechnical and Structures Laboratory of the US Army Engineer
   Research and Development Center, Vicksburg, MS. Any use of trade names
   is for descriptive purposes only and does not imply endorsement by the
   U.S. Government. The authors would like to thank those who reviewed the
   paper for their valuable comments.
NR 12
TC 2
Z9 2
U1 1
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0010-4655
J9 COMPUT PHYS COMMUN
JI Comput. Phys. Commun.
PD FEB
PY 2011
VL 182
IS 2
BP 281
EP 288
DI 10.1016/j.cpc.2010.09.008
PG 8
WC Computer Science, Interdisciplinary Applications; Physics, Mathematical
SC Computer Science; Physics
GA 699KF
UT WOS:000285661600001
ER

PT J
AU Douglas, TA
   Walsh, ME
   McGrath, CJ
   Weiss, CA
   Jaramillo, AM
   Trainor, TP
AF Douglas, Thomas A.
   Walsh, Marianne E.
   McGrath, Christian J.
   Weiss, Charles A.
   Jaramillo, Ashley Marie
   Trainor, Thomas P.
TI DESORPTION OF NITRAMINE AND NITROAROMATIC EXPLOSIVE RESIDUES FROM SOILS
   DETONATED UNDER CONTROLLED CONDITIONS
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Explosive residues; TNT; RDX; HMX
ID CLAY-MINERALS; COMPOSITION-B; SANDY SOIL; LIVE-FIRE; RDX; ADSORPTION;
   TNT; DISSOLUTION; 2,4,6-TRINITROTOLUENE; TRANSPORT
AB Potentially toxic nitroaromatic and nitramine compounds are introduced onto soils during detonation of explosives. The present study was conducted to investigate the desorption and transformation of explosive compounds loaded onto three soils through controlled detonation. The soils were proximally detonated with Composition B, a commonly Used military explosive containing 2,4,6-trinitrotoluene (TNT), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), and octahydro 1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX). Gas-exchangeable surface areas were measured from pristine and detonated soils. Aqueous batches of detonated soils were prepared by mixing each soil with ultrapure water. Samples were collected for 141 d and concentrations of Composition B compounds and TNT transformation products 2-amino-4,6-dinitrotoluene (2ADNT), 4-amino-2,6-dinitrotoluene (4ADNT), and I,3,5-trinitrobenzene (1,3,5-TNB) were measured. The RDX, HMX, and TNT concentrations in detonated soil batches exhibited first-order physical desorption for the first, roughly, 10 d and then reached steady state apparent equilibrium within 40 d. An aqueous batch containing powdered Composition B in water was sampled over time to quantify TNT, RDX, and HMX dissolution from undetonated Composition B particles. The TNT, RDX, and HMX concentrations in aqueous batches of pure Composition B reached equilibrium within 6, 11, and 20 d, respectively. Detonated soils exhibited lower gas-exchangeable surface areas than their pristine counterparts. This is likely due to an explosive residue coating on detonated soil surfaces, shock-induced compaction, sintering, and/or partial fusion of soil particles under the intense heat associated with detonation. Our results suggest that explosive compounds loaded to soils through detonation take longer to reach equilibrium concentrations in aqueous batches than soils loaded with explosive residues through aqueous addition. This is likely due to the heterogeneous interactions between explosive residues and soil particle surfaces. Environ. Toxicol. Chem. 2011;30:345-353. (C) 2010 SETAC
C1 [Douglas, Thomas A.; Jaramillo, Ashley Marie] USA, Engn Res & Dev Ctr, Ft Wainwright, AK 99703 USA.
   [Walsh, Marianne E.] USA, Engn Res & Dev Ctr, Hanover, NH USA.
   [McGrath, Christian J.; Weiss, Charles A.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA.
   [Jaramillo, Ashley Marie; Trainor, Thomas P.] Univ Alaska Fairbanks, Dept Chem, Fairbanks, AK USA.
RP Douglas, TA (reprint author), USA, Engn Res & Dev Ctr, Ft Wainwright, AK 99703 USA.
EM thomas.a.douglas@usace.army.mil
NR 40
TC 6
Z9 6
U1 0
U2 11
PU SETAC PRESS
PI PENSACOLA
PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2011
VL 30
IS 2
BP 345
EP 353
DI 10.1002/etc.383
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 710DB
UT WOS:000286490000011
PM 21038362
ER

PT J
AU Schulmeister, K
   Stuck, BE
   Lund, DJ
   Sliney, DH
AF Schulmeister, Karl
   Stuck, Bruce E.
   Lund, David J.
   Sliney, David H.
TI REVIEW OF THRESHOLDS AND RECOMMENDATIONS FOR REVISED EXPOSURE LIMITS FOR
   LASER AND OPTICAL RADIATION FOR THERMALLY INDUCED RETINAL INJURY
SO HEALTH PHYSICS
LA English
DT Review
DE laser; optics; radiation, non-ionizing; radiation damage
ID DAMAGE THRESHOLDS
AB Exposure limits (ELs) for laser and optical broadband radiation that are derived to protect the retina from adverse thermally-induced effects vary as a function of wavelength, exposure duration, and retinal irradiance diameter (spot size) expressed as the angular subtense alpha. A review of ex vivo injury threshold data shows that, in the ns regime, the microcavitation-induced damage mechanism results in retinal injury thresholds below thermal denaturation-induced thresholds. This appears to be the reason that the injury thresholds for retinal spot sizes of about 80 mu m (alpha = 6 mrad) and pulse durations of about 5 ns in the green wavelength range are very close to current ELs, calling for a reduction of the EL in the ns regime. The ELs, expressed in terms of retinal radiant exposure or radiance dose, currently exhibit a 1/alpha dependence up to a retinal spot size of 100 mrad, referred to as alpha max. For alpha >= alpha max, the EL is a constant retinal radiant exposure (no alpha dependence) for any given exposure duration. Recent ex vivo, computer model, and non-human primate in vivo threshold data provide a more complete assessment of the retinal irradiance diameter dependence for a wide range of exposure durations. The transition of the 1/alpha dependence to a constant retinal radiant exposure (or constant radiance dose) is not a constant alpha(max) but varies as a function of the exposure duration. The value of alpha max of 100 mrad reflects the spot size dependence of the injury thresholds only for longer duration exposures. The injury threshold data suggest that alpha max could increase as a function of the exposure duration, starting in the range of 5 mrad in the mu s regime, which would increase the EL for pulsed exposure and extended sources by up to a factor of 20, while still assuring an appropriate reduction factor between the injury threshold and the exposure limit. Health Phys. 100(2):210-220; 2011
C1 [Schulmeister, Karl] Seibersdorf Lab GmbH, A-2444 Seibersdorf, Austria.
   [Stuck, Bruce E.; Lund, David J.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Schulmeister, K (reprint author), Seibersdorf Lab GmbH, A-2444 Seibersdorf, Austria.
EM karl.schulmeister@seibersdorf-laboratories.at
NR 27
TC 15
Z9 16
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0017-9078
EI 1538-5159
J9 HEALTH PHYS
JI Health Phys.
PD FEB
PY 2011
VL 100
IS 2
BP 210
EP 220
DI 10.1097/HP.0b013e3181ea51e3
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical
   Imaging
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Nuclear Science & Technology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 700BR
UT WOS:000285707600011
PM 21399437
ER

PT J
AU Brett, PJ
   Burtnick, MN
   Heiss, C
   Azadi, P
   DeShazer, D
   Woods, DE
   Gherardini, FC
AF Brett, Paul J.
   Burtnick, Mary N.
   Heiss, Christian
   Azadi, Parastoo
   DeShazer, David
   Woods, Donald E.
   Gherardini, Frank C.
TI Burkholderia thailandensis oacA Mutants Facilitate the Expression of
   Burkholderia mallei-Like O Polysaccharides
SO INFECTION AND IMMUNITY
LA English
DT Article
ID VIRULENCE DETERMINANT; MURINE MACROPHAGES; PSEUDOMALLEI;
   LIPOPOLYSACCHARIDE; ACETYLATION; GLANDERS; ANTIGEN; IDENTIFICATION;
   MELIOIDOSIS; STRATEGIES
AB Previous studies have shown that the O polysaccharides (OPS) expressed by Burkholderia mallei are similar to those produced by Burkholderia thailandensis except that they lack the 4-O-acetyl modifications on their 6-deoxy-alpha-L-talopyranosyl residues. In the present study, we describe the identification and characterization of an open reading frame, designated oacA, expressed by B. thailandensis that accounts for this phenomenon. Utilizing the B. thailandensis and B. mallei lipopolysaccharide (LPS)-specific monoclonal antibodies Pp-PS-W and 3D11, Western immunoblot analyses demonstrated that the LPS antigens expressed by the oacA mutant, B. thailandensis ZT0715, were antigenically similar to those produced by B. mallei ATCC 23344. In addition, immunoblot analyses demonstrated that when B. mallei ATCC 23344 was complemented in trans with oacA, it synthesized B. thailandensis-like LPS antigens. To elucidate the structure of the OPS moieties expressed by ZT0715, purified samples were analyzed via nuclear magnetic resonance spectroscopy. As predicted, these studies demonstrated that the loss of OacA activity influenced the O acetylation phenotype of the OPS moieties. Unexpectedly, however, the results indicated that the O methylation status of the OPS antigens was also affected by the loss of OacA activity. Nonetheless, it was revealed that the LPS moieties expressed by the oacA mutant reacted strongly with the B. mallei LPS-specific protective monoclonal antibody 9C1-2. Based on these findings, it appears that OacA is required for the 4-O acetylation and 2-O methylation of B. thailandensis OPS antigens and that ZT0715 may provide a safe and cost-effective source of B. mallei-like OPS to facilitate the synthesis of glanders subunit vaccine candidates.
C1 [Brett, Paul J.; Burtnick, Mary N.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA.
   [Heiss, Christian; Azadi, Parastoo] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA.
   [DeShazer, David] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
   [Woods, Donald E.] Univ Calgary, Hlth Sci Ctr, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada.
   [Gherardini, Frank C.] NIAID, Lab Zoonot Pathogens, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA.
RP Brett, PJ (reprint author), Univ S Alabama, Dept Microbiol & Immunol, 5851 USA Dr N, Mobile, AL 36688 USA.
EM pbrett@jaguar1.usouthal.edu
FU NIH, National Institute of Allergy and Infectious Diseases; Department
   of Energy [DE-FG09-93ER-20097]; University of South Alabama
FX This research was supported in part by the Intramural Research Program
   of the NIH, National Institute of Allergy and Infectious Diseases, the
   Department of Energy-funded (DE-FG09-93ER-20097) Center for Plant and
   Microbial Complex Carbohydrates, and lab start-up funds from the
   University of South Alabama.
NR 43
TC 12
Z9 12
U1 0
U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0019-9567
J9 INFECT IMMUN
JI Infect. Immun.
PD FEB
PY 2011
VL 79
IS 2
BP 961
EP 969
DI 10.1128/IAI.01023-10
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA 709SP
UT WOS:000286462000043
PM 21115721
ER

PT J
AU Felix, AS
   Linkov, F
   Maxwell, GL
   Ragin, C
   Taioli, E
AF Felix, Ashley Sinclair
   Linkov, Faina
   Maxwell, George Larry
   Ragin, Camille
   Taioli, Emanuela
TI Racial Disparities in Risk of Second Primary Cancers in Patients With
   Endometrial Cancer Analysis of SEER Data
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
LA English
DT Article
DE Black; White; Endometrial cancer; Outcomes; Second primary cancer
ID DIABETES-MELLITUS; UTERINE CORPUS; P53 OVEREXPRESSION;
   COLORECTAL-CANCER; RADIATION-THERAPY; PHYSICAL-ACTIVITY;
   AFRICAN-AMERICAN; LEISURE-TIME; CARCINOMA; STAGE
AB Introduction: Endometrial cancer (EC) is the most common gynecologic cancer in the United States. Racial disparities in the incidence and mortality of this cancer are apparent; black women are less likely to develop this malignancy and yet are more likely to die when diagnosed. Racial differences of second primary cancer (SPC) have not been examined, and the goal of this study was to examine these differences.
   Methods: With the use of the National Cancer Institute's Surveillance, Epidemiology, and End Results database, SPC risk in white patients and black patients with EC was compared to the general population and to women with other primary cancers. Standardized incidence ratios (SIRs) of SPC (overall and by tumor site) with 95% confidence intervals were calculated. Poisson regression was used to estimate the race-specific risk of SPC in EC cases treated with radiotherapy versus nonirradiated cases.
   Results: The analysis included 11,047 patients with EC diagnosed between 1973 and 2007 that developed an SPC. Overall risk of SPC in white women with EC was significantly lower than that in the general population (SIR = 0.85; 95% CI, 0.84-0.87) but significantly higher in black women with EC (SIR = 1.19; 95% CI, 1.08-1.31). White women with EC treated with radiotherapy were more likely to develop SPC compared with nonirradiated cases (incidence rate ratio [IRR], 1.18; 95% CI, 1.14-1.23).
   Conclusions: This is the first analysis of race-specific SPC risk in EC cases, and it suggests differences between white women and black women with EC. Although exploratory, these data provide important clues about the etiology of SPC in patients with EC. This analysis also highlights the need for careful monitoring after diagnosis and treatment of EC.
C1 [Felix, Ashley Sinclair; Linkov, Faina] Univ Pittsburgh, Div Canc Prevent & Populat Sci, Inst Canc, Pittsburgh, PA 15232 USA.
   [Felix, Ashley Sinclair; Linkov, Faina] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15232 USA.
   [Maxwell, George Larry] Walter Reed Army Med Ctr, Gynecol Canc Ctr, Washington, DC 20307 USA.
   [Ragin, Camille; Taioli, Emanuela] Suny Downstate Med Ctr, Dept Epidemiol & Biostat, Brooklyn, NY 11203 USA.
RP Felix, AS (reprint author), Univ Pittsburgh, Div Canc Prevent & Populat Sci, Inst Canc, Suite 4C,5150 Ctr Ave, Pittsburgh, PA 15232 USA.
EM asf23@pitt.edu
FU National Institutes of Health [R25-CA057703]
FX This research was supported by a National Institutes of Health grant
   R25-CA057703.
NR 29
TC 2
Z9 2
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1048-891X
J9 INT J GYNECOL CANCER
JI Int. J. Gynecol. Cancer
PD FEB
PY 2011
VL 21
IS 2
BP 309
EP 315
DI 10.1097/IGC.0b013e318206a098
PG 7
WC Oncology; Obstetrics & Gynecology
SC Oncology; Obstetrics & Gynecology
GA 711XV
UT WOS:000286626200018
PM 21528021
ER

PT J
AU Lee, SY
   Hamlet, AF
   Fitzgerald, CJ
   Burges, SJ
AF Lee, Se-Yeun
   Hamlet, Alan F.
   Fitzgerald, Carolyn J.
   Burges, Stephen J.
TI Methodology for Developing Flood Rule Curves Conditioned on El
   Nino-Southern Oscillation Classification1
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE ENSO climate variability; ENSO-conditioned flood control curves;
   Columbia River Basin; Optimization-Simulation Model; )
ID COLUMBIA RIVER-BASIN; WESTERN UNITED-STATES; CLIMATE VARIABILITY;
   WATER-RESOURCES; DECADAL VARIABILITY; PACIFIC-NORTHWEST; STREAMFLOW;
   ENSO; INDICATORS; AUSTRALIA
AB Regional climate varies on interannual and decadal time scales that in turn affect annual streamflows, flood risks, and reservoir storage deficits in mid-summer. However, these variable elements of the climate system are generally not included in water resources operating policies that attempt to preserve a balance between flood risk and other water resources system objectives. A methodology for incorporating El Nino-Southern Oscillation (ENSO) information in designing flood control curves is investigated. An optimization-simulation procedure is used to develop a set of ENSO-conditioned flood control rule curves that relate streamflow forecasts to flood control evacuation requirements. ENSO-conditioned simulated flood risk and storage deficits under current operating policy are used to calibrate a unique objective function for each ENSO classification. Using a case study for the Columbia River Basin, we demonstrate that ENSO-conditioned flood control curves constructed using the optimization-simulation procedure consistently reduce storage deficits at a number of interrelated projects without increasing flood risk. For the Columbia Basin, the overall improvements in reservoir operations are relatively modest, and (in isolation) might not motivate a restructuring of flood control operations. However, the technique is widely applicable to a wide range of water resources systems and/or different climate indices.
C1 [Lee, Se-Yeun; Hamlet, Alan F.; Burges, Stephen J.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA.
   [Hamlet, Alan F.] Univ Washington, Climate Impacts Grp, Seattle, WA 98195 USA.
   [Hamlet, Alan F.] Univ Washington, CSES Climate Impacts Grp, Seattle, WA 98195 USA.
   [Fitzgerald, Carolyn J.] USA, Corps Engineers, Hydrol & Hydraul Branch, Seattle, WA 98134 USA.
RP Lee, SY (reprint author), Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98195 USA.
EM leesy@u.washington.edu
NR 38
TC 3
Z9 3
U1 1
U2 9
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1093-474X
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD FEB
PY 2011
VL 47
IS 1
BP 81
EP 92
DI 10.1111/j.1752-1688.2010.00490.x
PG 12
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
   Resources
SC Engineering; Geology; Water Resources
GA 711ZA
UT WOS:000286629700009
ER

PT J
AU Steers, NJ
   Currier, JR
   Kijak, GH
   di Targiani, RC
   Saxena, A
   Marovich, MA
   Kim, JH
   Michael, NL
   Alving, CR
   Rao, M
AF Steers, Nicholas J.
   Currier, Jeffrey R.
   Kijak, Gustavo H.
   di Targiani, Robert C.
   Saxena, Ashima
   Marovich, Mary A.
   Kim, Jerome H.
   Michael, Nelson L.
   Alving, Carl R.
   Rao, Mangala
TI Cell Type-Specific Proteasomal Processing of HIV-1 Gag-p24 Results in an
   Altered Epitope Repertoire
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID MHC-CLASS-I; IMMUNODEFICIENCY-VIRUS TYPE-1; ANTIGEN PRESENTATION;
   DENDRITIC CELLS; T-CELLS; TRIPEPTIDYL-PEPTIDASE; QUANTITATIVE-ANALYSIS;
   CROSS-PRESENTATION; 20S PROTEASOME; VIRAL LOAD
AB Proteasomes are critical for the processing of antigens for presentation through the major histocompatibility complex (MHC) class I pathway. HIV-1 Gag protein is a component of several experimental HIV-1 vaccines. Therefore, understanding the processing of HIV-1 Gag protein and the resulting epitope repertoire is essential. Purified proteasomes from mature dendritic cells (DC) and activated CD4(+) T cells from the same volunteer were used to cleave full-length Gag-p24 protein, and the resulting peptide fragments were identified by mass spectrometry. Distinct proteasomal degradation patterns and peptide fragments were unique to either mature DC or activated CD4(+) T cells. Almost half of the peptides generated were cell type specific. Two additional differences were observed in the peptides identified from the two cell types. These were in the HLA-B35-Px epitope and the HLA-B27-KK10 epitope. These epitopes have been linked to HIV-1 disease progression. Our results suggest that the source of generation of precursor MHC class I epitopes may be a critical factor for the induction of relevant epitope-specific cytotoxic T cells.
C1 [Rao, Mangala] US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA.
   [Steers, Nicholas J.; Currier, Jeffrey R.; Kijak, Gustavo H.] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20850 USA.
   [di Targiani, Robert C.; Saxena, Ashima] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA.
RP Rao, M (reprint author), US Mil HIV Res Program, Dept Adjuvant & Antigen Res, Div Retrovirol, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA.
EM mrao@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
   Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD)
   [W81XWH-07-2-0067]
FX This work was supported by a cooperative agreement (W81XWH-07-2-0067)
   between the Henry M. Jackson Foundation for the Advancement of Military
   Medicine, Inc., and the U.S. Department of Defense (DOD).
NR 71
TC 12
Z9 12
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD FEB
PY 2011
VL 85
IS 4
BP 1541
EP 1553
DI 10.1128/JVI.01790-10
PG 13
WC Virology
SC Virology
GA 709EP
UT WOS:000286420900012
PM 21106750
ER

PT J
AU Simpson-Holley, M
   Kedersha, N
   Dower, K
   Rubins, KH
   Anderson, P
   Hensley, LE
   Connor, JH
AF Simpson-Holley, M.
   Kedersha, N.
   Dower, K.
   Rubins, K. H.
   Anderson, P.
   Hensley, L. E.
   Connor, J. H.
TI Formation of Antiviral Cytoplasmic Granules during Orthopoxvirus
   Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID DOUBLE-STRANDED-RNA; MAMMALIAN STRESS GRANULES; UNFOLDED PROTEIN
   RESPONSE; VACCINIA VIRUS ANKARA; HOST-RANGE; TRANSLATIONAL CONTROL;
   BINDING-PROTEINS; MESSENGER-RNA; MEDIATED PHOSPHORYLATION;
   GENE-EXPRESSION
AB Vaccinia virus (VV) mutants lacking the double-stranded RNA (dsRNA)-binding E3L protein (Delta E3L mutant VV) show restricted replication in most cell types, as dsRNA produced by VV activates protein kinase R (PKR), leading to eIF2 alpha phosphorylation and impaired translation initiation. Here we show that cells infected with Delta E3L mutant VV assemble cytoplasmic granular structures which surround the VV replication factories at an early stage of the nonproductive infection. These structures contain the stress granule-associated proteins G3BP, TIA-1, and USP10, as well as poly(A)-containing RNA. These structures lack large ribosomal subunit proteins, suggesting that they are translationally inactive. Formation of these punctate structures correlates with restricted replication, as they occur in >80% of cells infected with Delta E3L mutant VV but in only 10% of cells infected with wild-type VV. We therefore refer to these structures as antiviral granules (AVGs). Formation of AVGs requires PKR and phosphorylated eIF2 alpha, as mouse embryonic fibroblasts (MEFs) lacking PKR displayed reduced granule formation and MEFs lacking phosphorylatable eIF2 alpha showed no granule formation. In both cases, these decreased levels of AVG formation correlated with increased Delta E3L mutant VV replication. Surprisingly, MEFs lacking the AVG component protein TIA-1 supported increased replication of Delta E3L mutant VV, despite increased eIF2 alpha phosphorylation and the assembly of AVGs that lacked TIA-1. These data indicate that the effective PKR-mediated restriction of Delta E3L mutant VV replication requires AVG formation subsequent to eIF2 alpha phosphorylation. This is a novel finding that supports the hypothesis that the formation of subcellular protein aggregates is an important component of the successful cellular antiviral response.
C1 [Simpson-Holley, M.; Dower, K.; Connor, J. H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
   [Kedersha, N.; Anderson, P.] Brigham & Womens Hosp, Div Rheumatol Immunol & Allergy, Boston, MA 02115 USA.
   [Rubins, K. H.] Nine Cambridge Ctr, Whitehead Inst Biomed Res, Cambridge, MA USA.
   [Hensley, L. E.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA.
RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, 72 E Concord St, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Connor, John/0000-0002-8867-7256
FU NIH [R01 (AI 033600), R01 (AR 051472)]
FX This work was supported by grants NIH R01 (AI 033600) and R01 (AR
   051472) awarded to P.A. J.H.C. was supported in part by the Peter Paul
   Career Development Professorship.
NR 53
TC 33
Z9 33
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD FEB
PY 2011
VL 85
IS 4
BP 1581
EP 1593
DI 10.1128/JVI.02247-10
PG 13
WC Virology
SC Virology
GA 709EP
UT WOS:000286420900016
PM 21147913
ER

PT J
AU Wichit, S
   Jittmittraphap, A
   Hidari, KIPJ
   Thaisomboonsuk, B
   Petmitr, S
   Ubol, S
   Aoki, C
   Itonori, S
   Morita, K
   Suzuki, T
   Suzuki, Y
   Jampangern, W
AF Wichit, Sineewanlaya
   Jittmittraphap, Akanitt
   Hidari, Kazuya I. P. J.
   Thaisomboonsuk, Butsaya
   Petmitr, Songsak
   Ubol, Sukathida
   Aoki, Chie
   Itonori, Saki
   Morita, Koichi
   Suzuki, Takashi
   Suzuki, Yasuo
   Jampangern, Wipawee
TI Dengue virus type 2 recognizes the carbohydrate moiety of neutral
   glycosphingolipids in mammalian and mosquito cells
SO MICROBIOLOGY AND IMMUNOLOGY
LA English
DT Article
DE dengue virus; MALDI-TOF; MS; TLC; virus-binding assay; viral receptors
ID HUMAN DENDRITIC CELLS; ENVELOPE PROTEIN; CALLIPHORA-VICINA; CHEMICAL
   STRUCTURES; LIVER-CELLS; IDENTIFICATION; BINDING; INFECTION; RECEPTOR;
   INSECTS
AB Dengue viruses infect cells by attaching to a surface receptor which remains unknown. The putative receptor molecules of dengue virus type 2 on the surface of mosquito (AP-61) and mammalian (LLC-MK2) cell lines were investigated. The immunochemical detection and structural analysis of carbohydrates demonstrated that the neutral glycosphingolipids, L-3 (GlcNAc beta 1-3Man beta 1-4Glc beta 1-1'Cer) in AP-61 cells, and nLc(4)Cer (Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1'Cer) in LLC-MK2 cells were recognized by the virus. These findings strongly suggest that neutral glycosphingolipids share the key determinant for virus binding and that the beta-GlcNAc residue may play an important role in dengue virus binding to the host cell surface.
C1 [Wichit, Sineewanlaya; Jittmittraphap, Akanitt; Jampangern, Wipawee] Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, Bangkok 10400, Thailand.
   [Petmitr, Songsak] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, Bangkok 10400, Thailand.
   [Wichit, Sineewanlaya; Thaisomboonsuk, Butsaya] Mahidol Univ, Armed Forces Res Inst Med Sci, US Army Med Component, Dept Virol, Bangkok 10400, Thailand.
   [Ubol, Sukathida] Mahidol Univ, Dept Microbiol, Fac Sci, Bangkok 10400, Thailand.
   [Hidari, Kazuya I. P. J.; Aoki, Chie; Suzuki, Takashi] Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Shizuoka 4228526, Japan.
   [Itonori, Saki] Shiga Univ, Fac Liberal Arts & Educ, Dept Chem, Shiga, Japan.
   [Morita, Koichi] Nagasaki Univ, Inst Trop Med, Dept Virol, Nagasaki, Japan.
   [Suzuki, Yasuo] Chubu Univ, Coll Life & Hlth Sci, Dept Biomed Sci, Kasugai, Aichi 487, Japan.
   [Hidari, Kazuya I. P. J.; Suzuki, Takashi; Suzuki, Yasuo] Univ Shizuoka, Global Ctr Excellence, Program Innovat Human Hlth Sci, Shizuoka 4228526, Japan.
   [Aoki, Chie] Univ Tokyo, Res Ctr Asian Infect Dis, Inst Med Sci, Beijing, Peoples R China.
RP Jampangern, W (reprint author), Mahidol Univ, Fac Trop Med, Dept Microbiol & Immunol, 420-6 Ratchavithi Rd, Bangkok 10400, Thailand.
EM suzukiy@isc.chubu.ac.jp; tmwus@mahidol.ac.th
FU Mahidol University; Southeast Asian Ministers of Education
   Organization/Regional Tropical Medicine and Public Health scholarship;
   Core Research and Technology (Japan Science and Technology Agency),
   Japan; Department of Virology, Armed Forces Research Institute of
   Medical Sciences, Thailand
FX This paper was supported and funded by Mahidol University and a
   Southeast Asian Ministers of Education Organization/Regional Tropical
   Medicine and Public Health scholarship. Part of this work was supported
   by Core Research and Technology (Japan Science and Technology Agency),
   Japan and the Department of Virology, Armed Forces Research Institute of
   Medical Sciences, Thailand.
NR 25
TC 9
Z9 9
U1 0
U2 10
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0385-5600
J9 MICROBIOL IMMUNOL
JI Microbiol. Immunol.
PD FEB
PY 2011
VL 55
IS 2
BP 135
EP 140
DI 10.1111/j.1348-0421.2010.00293.x
PG 6
WC Immunology; Microbiology
SC Immunology; Microbiology
GA 711UU
UT WOS:000286617700010
PM 21265875
ER

PT J
AU Shaltz, AT
   Leath, CA
   Wiedenhoefer, JF
   Sundborg, MJ
AF Shaltz, Abigail T.
   Leath, Charles A., III
   Wiedenhoefer, James F.
   Sundborg, Michael J.
TI Reaction to a Surgical Implant Foreign Body Masquerading as Recurrent
   Uterine Sarcoma
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
AB BACKGROUND: Multiple products to prevent adhesions or lessen the risk of soft tissue attachments are commercially available. The long-term nature of these products is unknown, and they may cause foreign body reactions masquerading as recurrent disease in patients with cancer.
   CASE: A perimenopausal female underwent a hysterectomy and placement of a surgical implant, polylactic acid. Final pathology revealed stage IA low-grade endometrial stromal sarcoma. Areas suspicious for recurrence were noted on radiographic imaging 1 year later, resulting in exploratory surgery. The suspicious areas were found to be foreign body reactions. Mass spectrometry identified the main component of the reactions as polylactic acid.
   CONCLUSION: Adhesion barriers and other surgical implants may not always be completely metabolized and should be used with caution in patients with cancer. (Obstet Gynecol 2011; 117: 450-2) DOI: 10.1097/AOG.0b013e3181f70bf0
C1 Brooke Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Ft Sam Houston, TX 78234 USA.
   Brooke Army Med Ctr, Dept Diagnost Radiol, Ft Sam Houston, TX 78234 USA.
   Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA.
RP Leath, CA (reprint author), Dept OB GYN, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM charles.leath@amedd.army.mil
OI Leath III, Charles/0000-0002-4034-6845
NR 8
TC 4
Z9 4
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD FEB
PY 2011
VL 117
IS 2
SU S
BP 450
EP 452
DI 10.1097/AOG.0b013e3181f70bf0
PN 2
PG 3
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA 714KQ
UT WOS:000286808900009
PM 21252785
ER

PT J
AU Wei, CM
   Kaplan, LM
   Burks, SD
   Blum, RS
AF Wei, Chuanming
   Kaplan, Lance M.
   Burks, Stephen D.
   Blum, Rick S.
TI Diffuse Prior Monotonic Likelihood Ratio Test for Evaluation of Fused
   Image Quality Measures
SO IEEE TRANSACTIONS ON IMAGE PROCESSING
LA English
DT Article
DE Fused image quality measures (FIQM); hypothesis test; image fusion;
   monotonic correlation (MC)
ID FUSION; PERFORMANCE; INFORMATION
AB This paper introduces a novel method to score how well proposed fused image quality measures (FIQMs) indicate the effectiveness of humans to detect targets in fused imagery. The human detection performance is measured via human perception experiments. A good FIQM should relate to perception results in a monotonic fashion. The method computes a new diffuse prior monotonic likelihood ratio (DPMLR) to facilitate the comparison of the H-1 hypothesis that the intrinsic human detection performance is related to the FIQM via a monotonic function against the null hypothesis that the detection and image quality relationship is random. The paper discusses many interesting properties of the DPMLR and demonstrates the effectiveness of the DPMLR test via Monte Carlo simulations. Finally, the DPMLR is used to score FIQMs with test cases considering over 35 scenes and various image fusion algorithms.
C1 [Wei, Chuanming; Blum, Rick S.] Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA.
   [Kaplan, Lance M.] USA, Res Lab, Adelphi, MD 20783 USA.
   [Burks, Stephen D.] Night Vis & Elect Sensors Directorate, Ctr Dev & Engn, Ft Belvoir, VA 22060 USA.
RP Wei, CM (reprint author), Lehigh Univ, Dept Elect & Comp Engn, Bethlehem, PA 18015 USA.
EM chw207@lehigh.edu; lance.m.kaplan@us.army.mil;
   stephen.burks1@us.army.mil; rblum@ece.lehigh.edu
FU Air Force Research Laboratory [FA9550-09-1-0576]; U.S. Army Research
   Laboratory [W911NF-06-2-0020]; National Science Foundation
   [CCF-0829958]; U.S. Army Research Office [W911NF-08-1-0449];
   Commonwealth of Pennsylvania, Department of Community and Economic
   Development
FX This work was supported by the Air Force Research Laboratory under
   agreement FA9550-09-1-0576, by the U.S. Army Research Laboratory under
   Grant W911NF-06-2-0020, by the National Science Foundation under Grant
   CCF-0829958, by the U.S. Army Research Office under Grant
   W911NF-08-1-0449, and by a grant from the Commonwealth of Pennsylvania,
   Department of Community and Economic Development. The associate editor
   coordinating the review of this manuscript and approving it for
   publication was Dr. Zhou Wang.
NR 42
TC 3
Z9 3
U1 0
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1057-7149
J9 IEEE T IMAGE PROCESS
JI IEEE Trans. Image Process.
PD FEB
PY 2011
VL 20
IS 2
BP 327
EP 344
DI 10.1109/TIP.2010.2060344
PG 18
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
   Electronic
SC Computer Science; Engineering
GA 708TR
UT WOS:000286387700003
PM 20656657
ER

PT J
AU Grujicic, M
   Arakere, G
   Pandurangan, B
   Hariharan, A
   Yen, CF
   Cheeseman, BA
AF Grujicic, M.
   Arakere, G.
   Pandurangan, B.
   Hariharan, A.
   Yen, C. -F.
   Cheeseman, B. A.
TI Development of a Robust and Cost-Effective Friction Stir Welding Process
   for Use in Advanced Military Vehicles
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE aluminum; automotive; joining; welding
ID MECHANICAL-PROPERTIES; 6061-T6 ALUMINUM; WELDED-JOINTS; MICROSTRUCTURE;
   ALLOY; SIMULATION; EVOLUTION
AB To respond to the advent of more lethal threats, recently designed aluminum-armor-based military-vehicle systems have resorted to an increasing use of higher strength aluminum alloys (with superior ballistic resistance against armor piercing (AP) threats and with high vehicle-light weighing potential). Unfortunately, these alloys are not very amenable to conventional fusion-based welding technologies and in-order to obtain high-quality welds, solid-state joining technologies such as Friction stir welding (FSW) have to be employed. However, since FSW is a relatively new and fairly complex joining technology, its introduction into advanced military vehicle structures is not straight forward and entails a comprehensive multi-step approach. One such (three-step) approach is developed in the present work. Within the first step, experimental and computational techniques are utilized to determine the optimal tool design and the optimal FSW process parameters which result in maximal productivity of the joining process and the highest quality of the weld. Within the second step, techniques are developed for the identification and qualification of the optimal weld joint designs in different sections of a prototypical military vehicle structure. In the third step, problems associated with the fabrication of a sub-scale military vehicle test structure and the blast survivability of the structure are assessed. The results obtained and the lessons learned are used to judge the potential of the current approach in shortening the development time and in enhancing reliability and blast survivability of military vehicle structures.
C1 [Grujicic, M.; Arakere, G.; Pandurangan, B.; Hariharan, A.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
   [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
EM mica.grujicic@ces.clemson.edu
FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; Army
   Research Office [W911NF-09-1-0513]
FX The material presented in this article is based on work supported by the
   U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and
   W911NF-06-2-0042 and by the Army Research Office sponsored Grant
   W911NF-09-1-0513.
NR 34
TC 24
Z9 24
U1 2
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD FEB
PY 2011
VL 20
IS 1
BP 11
EP 23
DI 10.1007/s11665-010-9650-0
PG 13
WC Materials Science, Multidisciplinary
SC Materials Science
GA 706IV
UT WOS:000286212500002
ER

PT J
AU Headley, SA
   Henry, K
   Nindl, BC
   Thompson, BA
   Kraemer, WJ
   Jones, MT
AF Headley, Samuel A.
   Henry, Kelley
   Nindl, Bradley C.
   Thompson, Brian A.
   Kraemer, William J.
   Jones, Margaret T.
TI EFFECTS OF LIFTING TEMPO ON ONE REPETITION MAXIMUM AND HORMONAL
   RESPONSES TO A BENCH PRESS PROTOCOL
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE cadence; endocrine; metabolic; plasma volume change; 1RM
ID RESISTANCE EXERCISE; PLASMA-VOLUME; STRENGTH; ADAPTATIONS; BLOOD
AB Headley, SA, Henry, K, Nindl, BC, Thompson, BA, Kraemer, WJ, and Jones, MT. Effects of lifting tempo on one repetition maximum and hormonal responses to a bench press protocol. J Strength Cond Res 25(2): 406-413, 2011-This study was carried out in 2 parts: part 1 was designed to measure the 1 repetition maximum (1RM) bench press with 2 different moderate-velocity tempos (2/0/2) vs. (2/0/4) in male lifters while part 2 compared the hormonal responses at the same tempos as described in part 1. In both parts 1 and 2, the 1RMs (lbs) were higher on the 2/0/2 tempo than on the 2/0/4 tempo. The change in plasma volume (PV) was greater after the 2/0/4 tempo (-5.7 +/- 1.7% vs. 0.96 +/- 1.2%, p < 0.05). All blood parameters were significantly (p < 0.05) higher post-exercise compared with baseline. With PV corrected, insulin-like growth factor 1 (IGF-1) (ng.mL(-1)) was higher with the 2/0/2 tempo only (pre-exercise: 277.4 +/- 21.8, post-exercise: 308.1 +/- 22.9; 2/0/4 tempo pre-exercise: 277.2 +/- 17.6, post-exercise: 284.8 +/- 21.2). In conclusion, heavier loads can be lifted and more total work can be performed using a (2/0/2) tempo compared with a slower (2/0/4) tempo, but with the exception of IGF-1, the hormonal responses are similar. Individuals may get the same metabolic responses to training by using different tempos, but they will need to use less weight at a slower tempo.
C1 [Headley, Samuel A.; Thompson, Brian A.; Jones, Margaret T.] Springfield Coll, Dept Exercise Sci & Sport Studies, Springfield, MA USA.
   [Henry, Kelley] Texas Womens Univ, Dept Kinesiol, Denton, TX USA.
   [Nindl, Bradley C.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA.
   [Kraemer, William J.] Univ Connecticut, Dept Kinesiol, Human Performance Lab, Storrs, CT USA.
RP Headley, SA (reprint author), Springfield Coll, Dept Exercise Sci & Sport Studies, Springfield, MA USA.
EM sheadley@spfldcol.edu
FU Springfield College; School of Health, Physical Education and Recreation
   at Springfield College
FX This work was funded by Buxton Grants from Springfield College.; The
   authors thank the subjects who volunteered to participate in these
   studies. Without their contribution, this study would not have been
   possible. We would also like to thank Sekeena Bacchus and Sarah Cahill
   for their assistance with data collection and Dr. Tracey Matthews for
   her help with the statistical analyses. Finally, we acknowledge the
   support of the School of Health, Physical Education and Recreation at
   Springfield College for the Buxton Award, which supplied the funds to
   complete these studies.
NR 24
TC 8
Z9 9
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD FEB
PY 2011
VL 25
IS 2
BP 406
EP 413
DI 10.1519/JSC.0b013e3181bf053b
PG 8
WC Sport Sciences
SC Sport Sciences
GA 709SI
UT WOS:000286461300017
PM 20351575
ER

PT J
AU Alisangco, JB
AF Alisangco, Jason Bravo
TI Transient New Left Bundle Branch Block in Acute Pancreatitis
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Meeting Abstract
C1 [Alisangco, Jason Bravo] Dwight D Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0038-4348
J9 SOUTH MED J
JI South.Med.J.
PD FEB
PY 2011
VL 104
IS 2
BP 159
EP 159
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 709RY
UT WOS:000286460300029
ER

PT J
AU DiPiro, C
   Kam, Y
   Ali, S
   Lanham, J
AF DiPiro, C.
   Kam, Y.
   Ali, S.
   Lanham, J.
TI Itching for Delivery: A Case of Papular Dermatitis of Pregnancy
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Meeting Abstract
C1 [DiPiro, C.; Kam, Y.; Ali, S.; Lanham, J.] Dwight D Eisenhower Army Med Ctr, Dept Family Med, Ft Gordon, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0038-4348
J9 SOUTH MED J
JI South.Med.J.
PD FEB
PY 2011
VL 104
IS 2
BP 160
EP 160
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA 709RY
UT WOS:000286460300032
ER

PT J
AU Chen, G
   Ployhart, RE
   Thomas, HC
   Anderson, N
   Bliese, PD
AF Chen, Gilad
   Ployhart, Robert E.
   Thomas, Helena Cooper
   Anderson, Neil
   Bliese, Paul D.
TI THE POWER OF MOMENTUM: A NEW MODEL OF DYNAMIC RELATIONSHIPS BETWEEN JOB
   SATISFACTION CHANGE AND TURNOVER INTENTIONS
SO ACADEMY OF MANAGEMENT JOURNAL
LA English
DT Article
ID ORGANIZATIONAL CITIZENSHIP BEHAVIORS; EMPLOYEE TURNOVER; UNFOLDING
   MODEL; TIME; SOCIALIZATION; GROWTH; COMMITMENT; IMPACT; WORK;
   CONSEQUENCES
AB This study offers a new theoretical perspective on the unique nature and function of job satisfaction change, or systematic improvement or decline in job satisfaction over time. Using four diverse samples, we show that differences in the extent to which job satisfaction systematically improves or declines account for change in employees' "turnover intentions" left unexplained by absolute (average) levels of job satisfaction. Further, we show that future-oriented work expectations partially mediate this relationship, and organizational tenure moderates the relationship between job satisfaction change and future-oriented work expectations. These findings provide new insights into the dynamic processes leading to turnover decisions.
C1 [Chen, Gilad] Univ Maryland, Robert H Smith Sch Business, College Pk, MD 20742 USA.
   [Ployhart, Robert E.] Univ S Carolina, Dept Management, Moore Sch Business, Columbia, SC 29208 USA.
   [Thomas, Helena Cooper] Univ Auckland, Dept Psychol, Auckland 1, New Zealand.
   [Anderson, Neil] Brunel Univ, Brunel Business Sch, Uxbridge UB8 3PH, Middx, England.
   [Bliese, Paul D.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA.
RP Chen, G (reprint author), Univ Maryland, Robert H Smith Sch Business, College Pk, MD 20742 USA.
EM giladchen@rhsmith.umd.edu; ployhart@moore.sc.edu;
   h.cooper-thomas@auckland.ac.nz; neil.anderson@brunel.ac.uk;
   paul.bliese@us.army.mil
RI pinto, rosiele/G-3761-2014
OI pinto, rosiele/0000-0003-3017-6683
NR 59
TC 83
Z9 93
U1 24
U2 155
PU ACAD MANAGEMENT
PI BRIARCLIFF MANOR
PA PACE UNIV, PO BOX 3020, 235 ELM RD, BRIARCLIFF MANOR, NY 10510-8020 USA
SN 0001-4273
EI 1948-0989
J9 ACAD MANAGE J
JI Acad. Manage. J.
PD FEB
PY 2011
VL 54
IS 1
BP 159
EP 181
PG 23
WC Business; Management
SC Business & Economics
GA 743LR
UT WOS:000289020300008
ER

PT J
AU Guo, JJ
   Wang, K
   Fujita, T
   McCauley, JW
   Singh, JP
   Chen, MW
AF Guo, J. J.
   Wang, K.
   Fujita, T.
   McCauley, J. W.
   Singh, J. P.
   Chen, M. W.
TI Nanoindentation characterization of deformation and failure of aluminum
   oxynitride
SO ACTA MATERIALIA
LA English
DT Article
DE Nanoindentation; Plasticity; Transmission electron microscopy; Fracture
   toughness
ID DYNAMIC COMPRESSIVE FAILURE; FRACTURE-TOUGHNESS; MECHANICAL-PROPERTIES;
   SPHERICAL INDENTERS; ELASTIC-MODULUS; BORON-CARBIDE; INDENTATION;
   CERAMICS; PLASTICITY; SILICON
AB A systematic study of the mechanical deformation and failure of transparent ceramic aluminum oxynitride (AlON) has been conducted using a depth-sensitive nanoindentation technique combined with transmission electron microscopy (TEM) and Raman spectroscopy. Although discrete displacement bursts appear in the load depth profiles at high applied forces, a detectable high-pressure phase transition has not been found by means of micro-Raman spectroscopy and TEM. Instead, a high density of dissociated < 1 1 0 > dislocations can be observed underneath the nanoindenters, suggesting that extensive plastic deformation takes place in the brittle ceramic at high contact pressures. Moreover, nanoindentation-induced micro-cracks oriented along well-defined crystallographic planes can also be observed, consistent with the low fracture toughness of AlON evaluated by an indentation method using Laugier's equation. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Guo, J. J.; Wang, K.; Fujita, T.; Chen, M. W.] Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan.
   [McCauley, J. W.] USA, Res Lab, Aberdeen Proving Ground, MD 21078 USA.
   [Singh, J. P.] US Army Int Technol Ctr, Tokyo 1060032, Japan.
   [Chen, M. W.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
RP Chen, MW (reprint author), Tohoku Univ, WPI Adv Inst Mat Res, Sendai, Miyagi 9808577, Japan.
EM mwchen@wpi-aimr.tohoku.ac.jp
RI Fujita, Takeshi/B-1867-2009; Wang, Ke/C-8021-2011; Chen,
   Mingwei/A-4855-2010; guo, junjie/I-3189-2012
OI Fujita, Takeshi/0000-0002-2318-0433; Chen, Mingwei/0000-0002-2850-8872;
   guo, junjie/0000-0002-3414-3734
FU "Global COE for Materials Research and Education", MEXT, Japan; US Army
   International Technology Center Pacific (ITC-PAC) of Tokyo; US Army
   Research Lab through Johns Hopkins University
FX This work is sponsored by "Global COE for Materials Research and
   Education", MEXT, Japan, US Army International Technology Center Pacific
   (ITC-PAC) of Tokyo, and US Army Research Lab through Johns Hopkins
   University.
NR 40
TC 18
Z9 19
U1 3
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
J9 ACTA MATER
JI Acta Mater.
PD FEB
PY 2011
VL 59
IS 4
BP 1671
EP 1679
DI 10.1016/j.actamat.2010.11.034
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
   Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 720FE
UT WOS:000287265100035
ER

PT J
AU Lu, F
   Lim, CS
   Nam, DH
   Kim, K
   Lin, K
   Kim, TS
   Lee, HW
   Chen, JH
   Wang, Y
   Sattabongkot, J
   Han, ET
AF Lu, Feng
   Lim, Chae Seung
   Nam, Deok-Hwa
   Kim, Kwonkee
   Lin, Khin
   Kim, Tong-Soo
   Lee, Hyeong-Woo
   Chen, Jun-Hu
   Wang, Yue
   Sattabongkot, Jetsumon
   Han, Eun-Taek
TI Genetic polymorphism in pvmdr1 and pvcrt-o genes in relation to in vitro
   drug susceptibility of Plasmodium vivax isolates from malaria-endemic
   countries
SO ACTA TROPICA
LA English
DT Article
DE Plasmodium vivax; Drug resistance gene; pvmdr1; pvcrt-o; Single
   nucleotide polymorphisms (SNPs); Copy number; In vitro drug
   susceptibility
ID CHLOROQUINE RESISTANCE; WESTERN BORDER; FALCIPARUM; THAILAND; KOREA;
   SENSITIVITY; CHEMOPROPHYLAXIS; AMPLIFICATION; MUTATIONS; PARASITES
AB Treatment failure of chloroquine for Plasmodium vivax infection has increased in endemic countries. However, the molecular mechanisms for resistance and in vitro susceptibility of P. vivax to chloroquine remain elusive. We investigated the prevalence of mutations in the pvmdr1 and pvcrt-o genes, and the copy number of the pvmdr1 gene in isolates from the Republic of Korea (ROK), Thailand, the Union of Myanmar (Myanmar), and Papua New Guinea (PNG). We also measured in vitro susceptibility of Korean isolates to antimalarial drugs. The pvmdr1 analysis showed that mutations at amino acid position Y976F of pvmdr1 were found in isolates from Thailand (17.9%), Myanmar (13.3%), and PNG (100%), but none from the ROK, and mutation at position F1076L was present in isolates from the ROK (100%), Thailand (60.7%), and Myanmar (46.7%). One copy of the pvmdr1 gene was observed in most isolates and double copy numbers of the gene were observed in two Thai isolates. In the exons of the pvcrt-o gene that were sequenced, a K10 insertion was present in isolates from Thailand (56.0%) and Myanmar (46.2%), and the wild type was found in all Korean isolates. The results suggest that gene polymorphisms and copy number variation was observed in isolates of P. vivax from Southeast Asian countries. In Korean isolates polymorphism as limited to the F1076L variant, and no isolates with high level of resistance were found by in vitro susceptibility determinations. Moreover, our results provide a baseline for future prospective drug studies in malaria-endemic areas. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Lu, Feng; Chen, Jun-Hu; Wang, Yue; Han, Eun-Taek] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, Gangwon Do, South Korea.
   [Lu, Feng] Jiangsu Inst Parasit Dis, Wuxi 214064, Peoples R China.
   [Lim, Chae Seung; Nam, Deok-Hwa] Korea Univ, Coll Med, Dept Lab Med, Seoul 152703, South Korea.
   [Kim, Kwonkee] Gachon Univ, Cheorwon Gil Hosp, Dept Internal Med, Cheorwon 269800, South Korea.
   [Chen, Jun-Hu; Wang, Yue] Zhejiang Acad Med Sci, Inst Parasit Dis, Hangzhou 310013, Zhejiang, Peoples R China.
   [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
   [Lin, Khin] Minist Hlth, Dept Hlth, Vector Borne Dis Control Project, Mandalay, Myanmar.
   [Kim, Tong-Soo] Inha Univ, Dept Parasitol, Sch Med, Inchon 400712, South Korea.
   [Lee, Hyeong-Woo] Korea Ctr Dis Control & Prevent, Dept Malaria & Parasite Dis, Natl Inst Hlth, Seoul 122701, South Korea.
   [Lee, Hyeong-Woo] Univ Florida, Dept Pathol, Gainesville, FL 32610 USA.
RP Han, ET (reprint author), Kangwon Natl Univ, Coll Med, Dept Parasitol, Hyoja2 Dong, Chunchon 200701, Gangwon Do, South Korea.
EM ethan@kangwon.ac.kr
FU Korean Government [KRF-2008-314-E00075]
FX This work received financial support from a National Research Foundation
   of Korea Grant funded by the Korean Government (KRF-2008-314-E00075).
NR 34
TC 18
Z9 20
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0001-706X
J9 ACTA TROP
JI Acta Trop.
PD FEB
PY 2011
VL 117
IS 2
BP 69
EP 75
DI 10.1016/j.actatropica.2010.08.011
PG 7
WC Parasitology; Tropical Medicine
SC Parasitology; Tropical Medicine
GA 718EP
UT WOS:000287104200002
PM 20933490
ER

PT J
AU Palmer, JC
   Moore, JD
   Brennan, JK
   Gubbins, KE
AF Palmer, Jeremy C.
   Moore, Joshua D.
   Brennan, John K.
   Gubbins, Keith E.
TI Adsorption and diffusion of argon in disordered nanoporous carbons
SO ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY
LA English
DT Article
DE Anomalous diffusion; Single-file diffusion; Nanoporous carbons;
   Simulation; Adsorption; Molecular dynamics; Activated carbons
ID REVERSE MONTE-CARLO; MOLECULAR-DYNAMICS SIMULATIONS; DENSITY-FUNCTIONAL
   THEORY; POROUS CARBONS; ACTIVE CARBONS; MICROPOROUS CARBONS;
   SELF-DIFFUSION; MODELS; EQUILIBRIUM; ETHYLENE
AB Application-specific optimization of disordered nanoporous carbons remains a formidable challenge due to the difficulty in accurately characterizing their microstructures with current empirical methods. Using molecular simulation techniques, we investigated the adsorptive and diffusive behavior of argon in three models of disordered nanoporous carbons. We found that the structural and morphological differences between these models gave rise to distinct phenomenological properties. The adsorptive behavior of argon in both the low and high pressure regimes was enhanced dramatically in the models with more crystalline microstructures. As for dynamic properties, we found that the adsorbent's structure and energetic topology significantly alters the rates of diffusion as well as the characteristics of the underlying diffusion mechanisms.
C1 [Palmer, Jeremy C.; Moore, Joshua D.; Gubbins, Keith E.] N Carolina State Univ, Inst Computat Sci & Engn, Raleigh, NC 27695 USA.
   [Palmer, Jeremy C.; Moore, Joshua D.; Gubbins, Keith E.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
   [Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Palmer, JC (reprint author), N Carolina State Univ, Inst Computat Sci & Engn, Raleigh, NC 27695 USA.
EM jcpalmer@ncsu.edu
FU US Defense Threat Reduction Agency [AA07CBT011]; U.S. National Science
   Foundation [CBET-0932656, CHE080046N]
FX J.C.P. gratefully acknowledges support from the US Defense Threat
   Reduction Agency (Project ID: AA07CBT011). J.D.M. benefited from support
   from the U.S. National Science Foundation (grant number CBET-0932656).
   Computational time was provided through a Teragrid Research Allocation
   by the U.S. National Science Foundation (grant No. CHE080046N).
NR 65
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U1 5
U2 32
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0929-5607
J9 ADSORPTION
JI Adsorpt.-J. Int. Adsorpt. Soc.
PD FEB
PY 2011
VL 17
IS 1
BP 189
EP 199
DI 10.1007/s10450-010-9308-0
PG 11
WC Chemistry, Physical; Engineering, Chemical
SC Chemistry; Engineering
GA 712KK
UT WOS:000286665400020
ER

PT J
AU Menjivar, J
AF Menjivar, Jorge
TI NURSING IN A COMBAT ZONE
SO AMERICAN JOURNAL OF NURSING
LA English
DT Letter
C1 US Army Reserve, Ft Benning, GA USA.
RP Menjivar, J (reprint author), US Army Reserve, Ft Benning, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0002-936X
J9 AM J NURS
JI Am. J. Nurs.
PD FEB
PY 2011
VL 111
IS 2
BP 12
EP 12
DI 10.1097/01.NAJ.0000394268.31814.92
PG 1
WC Nursing
SC Nursing
GA 711WT
UT WOS:000286622800004
ER

PT J
AU Jarman, RG
   Nisalak, A
   Anderson, KB
   Klungthong, C
   Thaisomboonsuk, B
   Kaneechit, W
   Kalayanarooj, S
   Gibbons, RV
AF Jarman, Richard G.
   Nisalak, Ananda
   Anderson, Kathryn B.
   Klungthong, Chonticha
   Thaisomboonsuk, Butsaya
   Kaneechit, Winai
   Kalayanarooj, Siripen
   Gibbons, Robert V.
TI Factors Influencing Dengue Virus Isolation by C6/36 Cell Culture and
   Mosquito Inoculation of Nested PCR-Positive Clinical Samples
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID LINKED-IMMUNOSORBENT-ASSAY; POLYMERASE CHAIN-REACTION;
   HEMORRHAGIC-FEVER; VIRAL LOAD; TOXORHYNCHITES MOSQUITOS; JAPANESE
   ENCEPHALITIS; PROPAGATE DENGUE; DISEASE SEVERITY; RAPID DIAGNOSIS;
   INFECTIONS
AB Dengue viral isolation is necessary for definitive diagnosis, pathogenesis and evolutionary research, vaccine candidates, and diagnostic materials. Using standardized techniques, we analyzed isolation rates of 1,544 randomly selected polymerase chain reaction (PCR)-positive samples, representing all four dengue serotypes, from patients with serologically confirmed dengue infections and evaluated Whether clinical and laboratory results could be predictive of isolation using standard and mosquito isolation techniques. Viruses were isolated from 62.5% of the samples by direct application to C6/36 cells and increased to 79.4% when amplifying C6/36 negative samples by intrathorasic inoculation in Toxyrhynchites splendens mosquitoes. High viremia, measured by reverse transcriptase (RT)-PCR, was a strong predictor for viral isolation by either method. Isolation was most successful in samples collected early in the disease, had low antibody levels, temperatures greater than 38 degrees C, and had a final clinical diagnosis of dengue fever. Dengue serotypes also played a role in the success of viral isolation.
C1 [Jarman, Richard G.; Nisalak, Ananda; Klungthong, Chonticha; Thaisomboonsuk, Butsaya; Kaneechit, Winai; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, US Army Med Component, Bangkok 10400, Thailand.
   [Anderson, Kathryn B.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
RP Jarman, RG (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, US Army Med Component, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM richard.jarman@afrims.org; AnandaN@afrims.org;
   kbander@LearnLink.Emory.Edu; ChontichaK@afrims.org; butsayaT@afrims.org;
   WinaiK@afrims.org; siripenk@gmail.com; robert.gibbons@afrims.org
FU United States Army Medical Research and Materiel Command (Fort Detrick,
   Frederick, MD)
FX This work was supported by the United States Army Medical Research and
   Materiel Command (Fort Detrick, Frederick, MD).
NR 35
TC 15
Z9 15
U1 0
U2 5
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2011
VL 84
IS 2
BP 218
EP 223
DI 10.4269/ajtmh.2011.09-0798
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 716WJ
UT WOS:000287003900006
PM 21292887
ER

PT J
AU Wang, Y
   Kaneko, O
   Sattabongkot, J
   Chen, JH
   Lu, F
   Chai, JY
   Takeo, S
   Tsuboi, T
   Ayala, FJ
   Chen, Y
   Lim, CS
   Han, ET
AF Wang, Yue
   Kaneko, Osamu
   Sattabongkot, Jetsumon
   Chen, Jun-Hu
   Lu, Feng
   Chai, Jong-Yil
   Takeo, Satoru
   Tsuboi, Takafumi
   Ayala, Francisco J.
   Chen, Yong
   Lim, Chae Seung
   Han, Eun-Taek
TI Genetic Polymorphism of Plasmodium vivax msp1p, a Paralog of Merozoite
   Surface Protein 1, from Worldwide Isolates
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID HUMAN MALARIA PARASITE; LOW-COMPLEXITY REGIONS; DIVERSITY; FALCIPARUM;
   POPULATIONS; SEARCH
AB Plasmodium vivax msp1p, a paralog of the candidate vaccine antigen P vivax merozoite surface protein I, possesses a signal peptide at its N-terminus and two epidermal growth factor like domains at its C-terminus with a glycosylphosphatidylinositol attachment site. The msp1p gene locus may have originated by a duplication of the msp1 gene locus in a common ancestor of the analyzed Plasmodium species and lost from P yoelii, P berghei, and P falciparum during their evolutionary history. Full-length sequences of the msp1 p gene were generally highly conserved; they had a few amino acid substitutions, one highly polymorphic E/Q-rich region, and a single-to-triple hepta-peptide repeat motif. Twenty-one distinguishable allelic types (A1-A21) of the E/Q-rich region were identified from worldwide isolates. Among them, four types were detected in isolates from South Korea. The length polymorphism of the E/Q-rich region might be useful as a genetic marker for population structure studies in malaria-endemic areas.
C1 [Wang, Yue; Chen, Jun-Hu] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, Gangwon Do, South Korea.
   [Wang, Yue; Chen, Jun-Hu] Zhejiang Acad Med Sci, Inst Parasit Dis, Hangzhou 310013, Zhejiang, Peoples R China.
   [Kaneko, Osamu] Nagasaki Univ, Dept Protozool, Inst Trop Med, Nagasaki 852, Japan.
   [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
   [Lu, Feng] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, Gangwon Do, South Korea.
   [Lu, Feng] Jiangsu Inst Parasit Dis, Wuxi 214064, Peoples R China.
   [Chai, Jong-Yil] Seoul Natl Univ, Coll Med, Dept Parasitol & Trop Med, Seoul, South Korea.
   [Takeo, Satoru] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan.
   [Ayala, Francisco J.] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA USA.
   [Chen, Yong] Zhejiang Acad Med Sci, Hangzhou 310013, Zhejiang, Peoples R China.
   [Lim, Chae Seung] Korea Univ, Coll Med, Dept Lab Med, Seoul 152703, South Korea.
   [Han, Eun-Taek] Kangwon Natl Univ, Dept Parasitol, Coll Med, Chunchon 200701, Gangwon Do, South Korea.
RP Han, ET (reprint author), Kangwon Natl Univ, Coll Med, Dept Parasitol, Hyoja2 Dong, Chunchon 200701, Gangwon Do, South Korea.
EM wangyuerr@yahoo.com.cn; okaneko@nagasaki-u.ac.jp; JetsumonP@afrims.org;
   hzjunhuchen@yahoo.com.cn; lufeng981@hotmail.com; cjy@snu.ac.kr;
   stakeo@ccr.ehime-u.ac.jp; tsuboi@ccr.ehime-u.ac.jp; fjayala@uci.edu;
   cyong93@yahoo.com.cn; malarim@korea.ac.kr; ethan@kangwon.ac.kr
RI Chai, Jong-Yil/D-5751-2012
FU National Research Foundation of Korea, Korean government [2009-075103]
FX This study was supported by National Research Foundation of Korea grant
   (2009-075103) from the Korean government.
NR 29
TC 3
Z9 3
U1 0
U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD FEB
PY 2011
VL 84
IS 2
BP 292
EP 297
DI 10.4269/ajtmh.2011.10-0432
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 716WJ
UT WOS:000287003900020
PM 21292901
ER

PT J
AU McGrath, SP
   Ryan, KL
   Wendelken, SM
   Rickards, CA
   Convertino, VA
AF McGrath, Susan P.
   Ryan, Kathy L.
   Wendelken, Suzanne M.
   Rickards, Caroline A.
   Convertino, Victor A.
TI Pulse Oximeter Plethysmographic Waveform Changes in Awake, Spontaneously
   Breathing, Hypovolemic Volunteers
SO ANESTHESIA AND ANALGESIA
LA English
DT Article
ID BODY NEGATIVE-PRESSURE; OPERATION IRAQI FREEDOM; ARTERIAL
   BLOOD-PRESSURE; 110 MM HG; IMPEDANCE CARDIOGRAPHY; REDEFINING
   HYPOTENSION; EARLY INDICATOR; FINGER; HUMANS; RESPONSES
AB BACKGROUND: The primary objective of this study was to determine whether alterations in the pulse oximeter waveform characteristics would track progressive reductions in central blood volume. We also assessed whether changes in the pulse oximeter waveform provide an indication of blood loss in the hemorrhaging patient before changes in standard vital signs.
   METHODS: Pulse oximeter data from finger, forehead, and ear pulse oximeter sensors were collected from 18 healthy subjects undergoing progressive reduction in central blood volume induced by lower body negative pressure (LBNP). Stroke volume measurements were simultaneously recorded using impedance cardiography. The study was conducted in a research laboratory setting where no interventions were performed. Pulse amplitude, width, and area under the curve (AUC) features were calculated from each pulse wave recording. Amalgamated correlation coefficients were calculated to determine the relationship between the changes in pulse oximeter waveform features and changes in stroke volume with LBNP.
   RESULTS: For pulse oximeter sensors on the ear and forehead, reductions in pulse amplitude, width, and area were strongly correlated with progressive reductions in stroke volume during LBNP (R-2 >= 0.59 for all features). Changes in pulse oximeter waveform features were observed before profound decreases in arterial blood pressure. The best correlations between pulse features and stroke volume were obtained from the forehead sensor area (R-2 = 0.97). Pulse oximeter waveform features returned to baseline levels when central blood volume was restored.
   CONCLUSIONS: These results support the use of pulse oximeter waveform analysis as a potential diagnostic tool to detect clinically significant hypovolemia before the onset of cardiovascular decompensation in spontaneously breathing patients. (Anesth Analg 2011;112:368-74)
C1 [McGrath, Susan P.; Wendelken, Suzanne M.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
   [Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, San Antonio, TX USA.
RP McGrath, SP (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
EM susan.p.mcgrath@dartmouth.edu
FU United States Army Medical Research and Materiel Command Combat Casualty
   Care Research Program [W81XWH-06-1-0509]
FX Supported by funding from the United States Army Medical Research and
   Materiel Command Combat Casualty Care Research Program (US Army Contract
   W81XWH-06-1-0509) to Dartmouth College.
NR 29
TC 29
Z9 34
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0003-2999
EI 1526-7598
J9 ANESTH ANALG
JI Anesth. Analg.
PD FEB
PY 2011
VL 112
IS 2
BP 368
EP 374
DI 10.1213/ANE.0b013e3181cb3f4a
PG 7
WC Anesthesiology
SC Anesthesiology
GA 711GV
UT WOS:000286576000014
PM 20103539
ER

PT J
AU Guo, HT
   Pan, XB
   Mao, RC
   Zhang, XC
   Wang, LJ
   Lu, XY
   Chang, JH
   Guo, JT
   Passic, S
   Krebs, FC
   Wigdahl, B
   Warren, TK
   Retterer, CJ
   Bavari, S
   Xu, XD
   Cuconati, A
   Block, TM
AF Guo, Haitao
   Pan, Xiaoben
   Mao, Richeng
   Zhang, Xianchao
   Wang, Lijuan
   Lu, Xuanyong
   Chang, Jinhong
   Guo, Ju-Tao
   Passic, Shendra
   Krebs, Fred C.
   Wigdahl, Brian
   Warren, Travis K.
   Retterer, Cary J.
   Bavari, Sina
   Xu, Xiaodong
   Cuconati, Andrea
   Block, Timothy M.
TI Alkylated Porphyrins Have Broad Antiviral Activity against
   Hepadnaviruses, Flaviviruses, Filoviruses, and Arenaviruses
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID HEPATITIS-B-VIRUS; REVERSE-TRANSCRIPTASE; DNA; CHLOROPHYLLIN; AFLATOXIN;
   ENVELOPE; CHEMOPREVENTION; INDIVIDUALS; REPLICATION; INHIBITION
AB We screened similar to 2,200 compounds known to be safe in people for the ability to reduce the amount of virion-associated hepatitis B virus (HBV) DNA in the culture medium of producer cells. These efforts led to the discovery of an alkylated porphyrin, chlorophyllide, as the compound that achieved the greatest reduction in signal. Here we report that chlorophyllide directly and quantitatively disrupted HBV virions at micromolar concentrations, resulting in the loss of all detectable virion DNA, without detectably affecting cell viability or intracellular viral gene products. Chemophores of chlorophyllide were also tested. Chlorin e6, a metal-free chlorophyllide-like molecule, showed the strongest antiviral activity against HBV as well as profound antiviral effects on other enveloped viruses, such as hepatitis C virus (HCV), human immunodeficiency virus (HIV), dengue virus (DENV), Marburg virus (MARV), Tacaribe virus (TCRV), and Junin viruses (JUNV). Remarkably, chlorin e6 inactivated DENV at subnanomolar-level concentrations. However, the compound had no antiviral effect against encephalomyocarditis virus and adenovirus, suggesting that chlorin e6 may be less active or inactive against nonenveloped viruses. Although other porphyrin derivatives have been previously reported to possess antiviral activity, this is the first analysis of the biochemical impact of chlorophyllide and chlorin e6 against HBV and of the dramatic anti-infectivity impact upon DENV. The possible application of this family of compounds as antiviral agents, as microbicides and systemic virus neutralizing agents, is discussed.
C1 [Guo, Haitao; Pan, Xiaoben; Mao, Richeng; Zhang, Xianchao; Wang, Lijuan; Lu, Xuanyong; Chang, Jinhong; Guo, Ju-Tao; Block, Timothy M.] Drexel Univ, Inst Biotechnol & Virol Res, Dept Microbiol & Immunol, Coll Med, Doylestown, PA 18902 USA.
   [Passic, Shendra; Krebs, Fred C.; Wigdahl, Brian] Drexel Univ, Dept Microbiol & Immunol, Coll Med, Philadelphia, PA 19104 USA.
   [Passic, Shendra; Krebs, Fred C.; Wigdahl, Brian] Drexel Univ, Ctr Mol Therapeut & Resistance, Ctr Sexually Transmitted Dis, Inst Mol Med & Infect Dis,Coll Med, Philadelphia, PA 19104 USA.
   [Warren, Travis K.; Retterer, Cary J.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA.
   [Mao, Richeng; Xu, Xiaodong; Cuconati, Andrea; Block, Timothy M.] Hepatitis B Fdn, Inst Hepatitis & Virus Res, Doylestown, PA 18902 USA.
RP Block, TM (reprint author), Drexel Univ, Inst Biotechnol & Virol Res, Dept Microbiol & Immunol, Coll Med, 3805 Old Easton Rd, Doylestown, PA 18902 USA.
EM Timothy.Block@drexelmed.edu
FU National Institutes of Health [AI061441]; Hepatitis B Foundation;
   Department of Microbiology and Immunology; Institute for Molecular
   Medicine and Infectious Disease, Drexel University College of Medicine;
   Joint Science and Technology Office Transformational Medical
   Technologies Initiative [TMTI0048_09_RD_T]; Defense Threat Reduction
   Agency [4.10022_08_RD_B]
FX This work was supported by a grant from the National Institutes of
   Health (AI061441) and by the Hepatitis B Foundation through an
   appropriation of the Commonwealth of Pennsylvania. Work in Fred Krebs'
   laboratory was supported by research development funds provided by the
   Department of Microbiology and Immunology and the Institute for
   Molecular Medicine and Infectious Disease, Drexel University College of
   Medicine. Work in Sina Bavari's laboratory was supported by a grant from
   the Joint Science and Technology Office Transformational Medical
   Technologies Initiative (TMTI0048_09_RD_T) and Defense Threat Reduction
   Agency (4.10022_08_RD_B). Haitao Guo is the Bruce Witte Fellow of the
   Hepatitis B Foundation.
NR 33
TC 25
Z9 25
U1 1
U2 8
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD FEB
PY 2011
VL 55
IS 2
BP 478
EP 486
DI 10.1128/AAC.00989-10
PG 9
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA 709FE
UT WOS:000286422500003
PM 21135183
ER

PT J
AU Kalb, SR
   Baudys, J
   Egan, C
   Smith, TJ
   Smith, LA
   Pirkle, JL
   Barr, JR
AF Kalb, Suzanne R.
   Baudys, Jakub
   Egan, Christina
   Smith, Theresa J.
   Smith, Leonard A.
   Pirkle, James L.
   Barr, John R.
TI Different Substrate Recognition Requirements for Cleavage of
   Synaptobrevin-2 by Clostridium baratii and Clostridium botulinum Type F
   Neurotoxins
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID SEROTYPE-A; NEUROTRANSMITTER RELEASE; B NEUROTOXIN; MASS-SPECTROMETRY;
   UNITED-STATES; ENDOPEP-MS; TOXIN; SNAP-25; VAMP/SYNAPTOBREVIN;
   IDENTIFICATION
AB Botulinum neurotoxins (BoNTs) cause botulism, which can be fatal if it is untreated. BoNTs cleave proteins necessary for nerve transmission, resulting in paralysis. The in vivo protein target has been reported for all seven serotypes of BoNT, i.e., serotypes A to G. Knowledge of the cleavage sites has led to the development of several assays to detect BoNT based on its ability to cleave a peptide substrate derived from its in vivo protein target. Most serotypes of BoNT can be subdivided into subtypes, and previously, we demonstrated that three of the currently known subtypes of BoNT/F cleave a peptide substrate, a shortened version of synaptobrevin-2, between Q58 and K59. However, our research indicated that Clostridium baratii type F toxin did not cleave this peptide. In this study, we detail experiments demonstrating that Clostridium baratii type F toxin cleaves recombinant synaptobrevin-2 in the same location as that cleaved by proteolytic F toxin. In addition, we demonstrate that Clostridium baratii type F toxin can cleave a peptide substrate based on the sequence of synaptobrevin-2. This peptide substrate is an N-terminal extension of the original peptide substrate used for detection of other BoNT/F toxins and can be used to detect four of the currently known BoNT/F subtypes by mass spectrometry.
C1 [Kalb, Suzanne R.; Pirkle, James L.; Barr, John R.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, Atlanta, GA 30341 USA.
   [Baudys, Jakub] Ctr Dis Control & Prevent, Battelle Mem Inst, Atlanta, GA 30341 USA.
   [Egan, Christina] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12208 USA.
   [Smith, Theresa J.; Smith, Leonard A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Barr, JR (reprint author), Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Div Sci Lab, 4770 Buford Hwy NE, Atlanta, GA 30341 USA.
EM jbarr@cdc.gov
OI Kalb, Suzanne/0000-0002-8067-136X
NR 46
TC 13
Z9 13
U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD FEB
PY 2011
VL 77
IS 4
BP 1301
EP 1308
DI 10.1128/AEM.01662-10
PG 8
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA 717WM
UT WOS:000287078100018
PM 21169446
ER

PT J
AU Cooper, JB
   Larkin, CM
   Schmitigal, J
   Morris, RE
   Abdelkader, MF
AF Cooper, John B.
   Larkin, Christopher M.
   Schmitigal, Joel
   Morris, Robert E.
   Abdelkader, Mohamed F.
TI Rapid Analysis of Jet Fuel Using a Handheld Near-Infrared (NIR) Analyzer
SO APPLIED SPECTROSCOPY
LA English
DT Article
DE Jet fuel; Multivariate analysis; Partial least squares; PLS;
   Near-infrared spectroscopy; NIR spectroscopy; Handheld instrumentation
ID PARTIAL LEAST-SQUARES; SPECTROSCOPY DATA; MULTIVARIATE CALIBRATION;
   GASOLINE CLASSIFICATION; QUALITY; MODELS; PREDICTION; REGRESSION;
   SPECTRA; VISCOSITY
AB A handheld near-infrared (NIR) analyzer was used to build partial least squares (PLS) models relating jet fuel properties to the spectral data (880-1570 nm). The properties included: API gravity, % aromatics, cetane index, density, 10%/50%/90% recovered distillation temperatures, freezing point, flashpoint, hydrogen content, and % saturates. The models were validated using leave-one-out validation of the training sets and by predicting an independent test set of fuels. The repeatability of the developed NIR methods was determined by performing replicate measurements on a single master analyzer. The reproducibility of the NIR methods was determined by performing measurements on multiple samples using five different analyzers. The results indicate that the NIR methods are useful for rapid monitoring of jet fuel quality at commercial airports during transport, storage, and distribution.
C1 [Cooper, John B.; Abdelkader, Mohamed F.] Old Dominion Univ, Dept Chem, Norfolk, VA 23529 USA.
   [Larkin, Christopher M.] Bruker Opt, The Woodlands, TX 77381 USA.
   [Schmitigal, Joel] USA, RDECOM TARDEC, Warren, MI 48397 USA.
   [Morris, Robert E.] USN, Res Lab, Washington, DC 20375 USA.
RP Cooper, JB (reprint author), Old Dominion Univ, Dept Chem, Norfolk, VA 23529 USA.
EM jbc@brukeroptics.com
NR 53
TC 7
Z9 7
U1 2
U2 17
PU SOC APPLIED SPECTROSCOPY
PI FREDERICK
PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA
SN 0003-7028
J9 APPL SPECTROSC
JI Appl. Spectrosc.
PD FEB
PY 2011
VL 65
IS 2
BP 187
EP 192
DI 10.1366/10-06076
PG 6
WC Instruments & Instrumentation; Spectroscopy
SC Instruments & Instrumentation; Spectroscopy
GA 710XE
UT WOS:000286549500009
ER

PT J
AU Bannon, DI
   Parsons, PJ
   Centeno, JA
   Lal, S
   Xu, HN
   Rosencrance, AB
   Dennis, WE
   Johnson, MS
AF Bannon, Desmond I.
   Parsons, Patrick J.
   Centeno, Jose A.
   Lal, Simina
   Xu, Hanna
   Rosencrance, Alan B.
   Dennis, William E.
   Johnson, Mark S.
TI Lead and Copper in Pigeons (Columbia livia) Exposed to a Small
   Arms-Range Soil
SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
ID COLINUS-VIRGINIANUS; SHOOTING RANGES; MOURNING DOVES; METAL LEVELS;
   FEATHERS; BLOOD; BIRDS; BIOAVAILABILITY; PASSERINES; GEOPHAGY
AB Small arms-range (SAR) soils can be contaminated with metals from spent copper (Cu)-jacketed bullets. Avian species are particularly at risk because they are exposed to lead (Pb) through ingestion of grit, soil intake from preening, or ingestion of contaminated food near ranges. Examination of the effects of Pb on birds at ranges have mainly focused on intake and toxicity of Pb shot pellets or fragments; however, Pb in soils may be an important pathway of exposure. To evaluate the uptake and effects of Pb from an actual range, the soil fraction (< 250 mu m) from a contaminated SAR soil was used to dose pigeons (Columbia livia) for 14 days at low (2700 mu g Pb and 215 mu g Cu/d) and high (5400 mu g Pb and 430 mu g Cu/d) doses. At the end of the study, blood Pb and erythrocyte protoporphyrin were determined, and tissues were analyzed for Pb and Cu. Results showed that Pb was absorbed in a dose-response manner in blood, tissues, and feathers, and erythrocyte protoporphyrin, a biomarker of early Pb effect, was increased at blood Pb levels > 50 mu g/dL. Four tissues showed differential retention of Pb, with kidney having the highest concentration followed by liver, brain, and heart, whereas Cu levels were not changed. To examine possible interactions with other metals, amendments of either Cu or tungstate were made to the soil sample. Although these amendments seemed to decrease the absorption of Pb, the results were ambiguous compared with sodium chloride controls. Overall, this study showed that intake of SAR soils contaminated with Pb and Cu causes an increase in Pb body burdens in birds and that the response can be modulated by amending soils with salts of metals.
C1 [Bannon, Desmond I.; Johnson, Mark S.] USA, Hlth Effects Res Program, Directorate Toxicol, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA.
   [Centeno, Jose A.; Lal, Simina; Xu, Hanna] USA, Div Biophys Toxicol, Dept Environm & Infect Dis Sci, Armed Forces Inst Pathol, Washington, DC 20306 USA.
   [Parsons, Patrick J.] New York State Dept Hlth, Lab Inorgan & Nucl Chem, Div Environm Hlth Sci, Wadsworth Ctr, Albany, NY 12201 USA.
   [Parsons, Patrick J.] SUNY Albany, Sch Publ Hlth, Dept Environm Hlth Sci, Albany, NY 12201 USA.
   [Rosencrance, Alan B.; Dennis, William E.] USA, Dept Chem, Ctr Environm Hlth Res, Ft Detrick, MD 21702 USA.
RP Bannon, DI (reprint author), USA, Hlth Effects Res Program, Directorate Toxicol, Publ Hlth Command Provis, Aberdeen Proving Ground, MD 21010 USA.
EM desmond.bannon@us.army.mil
OI Parsons, Patrick/0000-0001-9133-875X
NR 37
TC 6
Z9 6
U1 3
U2 32
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-4341
J9 ARCH ENVIRON CON TOX
JI Arch. Environ. Contam. Toxicol.
PD FEB
PY 2011
VL 60
IS 2
BP 351
EP 360
DI 10.1007/s00244-010-9540-3
PG 10
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 711OK
UT WOS:000286601100017
PM 20523978
ER

PT J
AU Ji, ZQ
   Li, YJ
   Pritchett, TM
   Makarov, NS
   Haley, JE
   Li, ZJ
   Drobizhev, M
   Rebane, A
   Sun, WF
AF Ji, Zhiqiang
   Li, Yunjing
   Pritchett, Timothy M.
   Makarov, Nikolay S.
   Haley, Joy E.
   Li, Zhongjing
   Drobizhev, Mikhail
   Rebane, Aleksander
   Sun, Wenfang
TI One-Photon Photophysics and Two-Photon Absorption of
   4-[9,9-Di(2-ethylhexyl)-7-diphenylaminofluoren-2-yl]-2,2 ':6 ',2
   ''-terpyridine and Their Platinum Chloride Complexes
SO CHEMISTRY-A EUROPEAN JOURNAL
LA English
DT Article
DE luminescence; nonlinear optics; photophysics; platinum; two-photon
   absorption
ID INTRAMOLECULAR CHARGE-TRANSFER; CONJUGATED PORPHYRIN DIMERS;
   CROSS-SECTIONS; OPTICAL-PROPERTIES; DERIVATIVES; FLUORESCENCE;
   MOLECULES; LUMINESCENCE; MICROFABRICATION; PHTHALOCYANINES
AB The synthesis, one-photon photophysics and two-photon absorption (2PA) of three dipolar D-pi-A 4-[9,9-di(2-ethylhexyl)-7-diphenylaminofluoren-2-yl]-2,2':6',2 ''-terpyridine and their platinum chloride complexes with different linkers between the donor and acceptor are reported. All ligands exhibit (1)pi,pi* transition in the UV and (1)pi,pi*/(1)ICT (intramolecular charge transfer) transition in the visible regions, while the complexes display a lower-energy (1)pi,pi*/(1)CT (charge trans-fer) transition in the visible region in addition to the high-energy (1)pi,pi* transitions. All ligands and the complexes are emissive at room temperature and 77 K, with the emitting excited state assigned as the mixed (1)pi,pi* and (1)CT states at RT. Transient absorption from the ligands and the complexes were ob-served. 2PA was investigated for all ligands and complexes. The two-photon absorption cross-sections (sigma(2)) of the complexes (600-2000 GM) measured by Z-scan experiment are much larger than those of their corresponding ligands measured by the two-photon induced fluorescence method. The ligand and the complex with the ethynylene linker show much stronger 2PA than those with the vinylene linker.
C1 [Ji, Zhiqiang; Li, Yunjing; Li, Zhongjing; Sun, Wenfang] N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA.
   [Pritchett, Timothy M.] USA, Res Lab, AMSRD SE EM, Adelphi, MD 20783 USA.
   [Makarov, Nikolay S.; Drobizhev, Mikhail; Rebane, Aleksander] Montana State Univ, Dept Phys, Bozeman, MT 59717 USA.
   [Haley, Joy E.] USAF, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA.
   [Haley, Joy E.] Universal Energy Syst Inc, Dayton, OH 45432 USA.
RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Biochem, Fargo, ND 58108 USA.
EM Wenfang.Sun@ndsu.edu
RI ji, zhiqiang/A-2372-2010; li, zhongjing/H-4945-2014
OI li, zhongjing/0000-0002-0125-9693
FU National Science Foundation [CHE-0449598]; Army Research Laboratory
   [W911NF-06-2-0032]
FX W.S. acknowledges the financial support from the National Science
   Foundation (CAREER CHE-0449598) and the Army Research Laboratory
   (W911NF-06-2-0032).
NR 48
TC 46
Z9 47
U1 1
U2 43
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0947-6539
J9 CHEM-EUR J
JI Chem.-Eur. J.
PD FEB
PY 2011
VL 17
IS 8
BP 2479
EP 2491
DI 10.1002/chem.201001449
PG 13
WC Chemistry, Multidisciplinary
SC Chemistry
GA 731HL
UT WOS:000288096800025
PM 21264958
ER

PT J
AU Garcia-Reyero, N
   Perkins, EJ
AF Garcia-Reyero, Natalia
   Perkins, Edward J.
TI SYSTEMS BIOLOGY: LEADING THE REVOLUTION IN ECOTOXICOLOGY
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article; Proceedings Paper
CT 30th Annual Meeting of SETAC-North -America
CY NOV 19-23, 2009
CL New Orleans, LA
SP SETAC N Amer
DE Omics; Genomics; Systems biology; Aquatic toxicology; Ecotoxicology
ID MINNOW PIMEPHALES-PROMELAS; ZEBRAFISH DANIO-RERIO; FLOUNDER
   PLATICHTHYS-FLESUS; EXPRESSION PROFILES; FATHEAD MINNOWS; ENVIRONMENTAL
   METABOLOMICS; BIOCHEMICAL RESPONSES; COMPUTATIONAL MODEL; RAINBOW-TROUT;
   END-POINTS
AB The rapid development of new technologies such as transcriptomics, proteomics, and metabolomics (Omics) are changing the way ecotoxicology is practiced. The data deluge has begun with genomes of over 65 different aquatic species that are currently being sequenced, and many times that number with at least some level of transcriptome sequencing. Integrating these top-down methodologies is an essential task in the field of systems biology. Systems biology is a biology-based interdisciplinary field that focuses on complex interactions in biological systems, with the intent to model and discover emergent properties of the system. Recent studies demonstrate that Omics technologies provide valuable insight into ecotoxicity, both in laboratory exposures with model organisms and with animals exposed in the field. However, these approaches require a context of the whole animal and population to be relevant. Powerful approaches using reverse engineering to determine interacting networks of genes, proteins, or biochemical reactions are uncovering unique responses to toxicants. Modeling efforts in aquatic animals are evolving to interrelate the interacting networks of a system and the flow of information linking these elements. Just as is happening in medicine, systems biology approaches that allow the integration of many different scales of interaction and information are already driving a revolution in understanding the impacts of pollutants on aquatic systems. Environ. Toxicol. Chem. 2011;30:265-273. (C) 2010 SETAC
C1 [Garcia-Reyero, Natalia] Jackson State Univ, Jackson, MS 39217 USA.
   [Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Garcia-Reyero, N (reprint author), Jackson State Univ, Jackson, MS 39217 USA.
EM natalia@icnanotox.org
NR 75
TC 44
Z9 45
U1 7
U2 59
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD FEB
PY 2011
VL 30
IS 2
BP 265
EP 273
DI 10.1002/etc.401
PG 9
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA 710DB
UT WOS:000286490000002
PM 21072840
ER

PT J
AU Subhash, G
   Liu, Q
   Moore, DF
   Ifju, PG
   Haile, MA
AF Subhash, G.
   Liu, Q.
   Moore, D. F.
   Ifju, P. G.
   Haile, M. A.
TI Concentration Dependence of Tensile Behavior in Agarose Gel Using
   Digital Image Correlation
SO EXPERIMENTAL MECHANICS
LA English
DT Article
DE Agarose gel; Soft materials; Digital image correlation; Tensile response
ID MECHANICAL-PROPERTIES; HYDRAULIC PERMEABILITY; IDENTIFICATION;
   CARTILAGE; INSIGHT; TISSUES
AB Tensile testing of soft, slippery biological materials is a challenging task due to the difficulties associated with the gripping method and accurate measurement of axial and lateral strains. In this manuscript, the above issues were effectively resolved by using a shoulder-supported tensile specimen and digital image correlation (DIC) technique, respectively. The tensile response of agarose gel with concentration ranging from 1.5 to 4.0 wt% was determined using the above method. Unlike the previous literature where the tensile strain was obtained from machine crosshead displacement, the DIC technique utilized a speckle pattern introduced into the gage area to obtain full-field maps of axial and lateral strains. It is found that the tensile strength and modulus of agarose gel increases linearly with an increase in agarose concentration. The Poisson's ratio was determined to be around 0.5 for virgin specimens and it decreased slightly with axial strain, possibly due to the loss of water during deformation.
C1 [Subhash, G.; Liu, Q.; Ifju, P. G.; Haile, M. A.] Univ Florida, Dept Mech & Aerosp, Gainesville, FL 32611 USA.
   [Liu, Q.; Moore, D. F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA.
RP Subhash, G (reprint author), Univ Florida, Dept Mech & Aerosp, Gainesville, FL 32611 USA.
EM Subhash@ufl.edu
FU Massachusetts Institute of Technology-Institute for Soldier
   Nanotechnology, US Army Research Office; JIEDDO; CDMRP; Henry M. Jackson
   Foundation
FX This work was supported by a grant from Massachusetts Institute of
   Technology-Institute for Soldier Nanotechnology, US Army Research Office
   and JIEDDO. Qunli Liu sincerely acknowledges support from CDMRP and
   Henry M. Jackson Foundation Fellowship.
NR 30
TC 7
Z9 8
U1 2
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0014-4851
J9 EXP MECH
JI Exp. Mech.
PD FEB
PY 2011
VL 51
IS 2
BP 255
EP 262
DI 10.1007/s11340-010-9354-2
PG 8
WC Materials Science, Multidisciplinary; Mechanics; Materials Science,
   Characterization & Testing
SC Materials Science; Mechanics
GA 711VF
UT WOS:000286618800010
ER

PT J
AU Gregory, SM
   Headley, SA
   Germain, M
   Flyvbjerg, A
   Frystyk, J
   Coughlin, MA
   Milch, CM
   Sheila, S
   Nindl, BC
AF Gregory, Sara M.
   Headley, Samuel A.
   Germain, Michael
   Flyvbjerg, Allan
   Frystyk, Jan
   Coughlin, Mary Ann
   Milch, Charles M.
   Sullivan, Sheila
   Nindl, Bradley C.
TI Lack of circulating bioactive and immunoreactive IGF-I changes despite
   improved fitness in chronic kidney disease patients following 48 weeks
   of physical training
SO GROWTH HORMONE & IGF RESEARCH
LA English
DT Article
DE Exercise; Insulin-like growth factor binding proteins; KIRA; Renal
   disease
ID GROWTH-FACTOR-I; SYSTEM RESPONSES; ENERGY-BALANCE; FACTOR (IGF)-I;
   RENAL-DISEASE; INSULIN; EXERCISE; RESISTANCE; WOMEN; CATABOLISM
AB Objective: As known abnormalities exist in the insulin-like growth factor (IGF) system in chronic kidney disease (CKD) patients, the measurement of bioactive IGF-I may provide further insight into the therapeutic potential of long-term exercise training.
   Design: Patients (N = 21) with stages 3 and 4 CKD were recruited from a local nephrology practice in Springfield, MA and randomized into matched treatment and control groups. The treatment group participated in 48 weeks of supervised, progressive exercise training and dietary counseling, while the control group received only usual care. Treadmill testing, anthropometric measurements, and blood samples for analysis of immunoreactive IGF-I, IGF-II, IGFBP-1 and -2, and bioactive IGF-I were taken at baseline, 24 weeks, and 48 weeks.
   Results: There were no significant differences in any of the components of the IGF system (all p-values > 0.05). Immunoreactive IGF-I levels correlated significantly with bioactive IGF-I at baseline (r = 0.50, p = 0.02) and at 48 weeks (r = 0.64, p = 0.01). There was a significant interaction between group and time for both VO(2peak) (p = 0.03) and total treadmill time TT (p < 0.01).
   Conclusions: Despite improvements in physical performance, a 48-week training program did not affect any of the circulating IGF system measurements. Disparities between these findings and those of other researchers reporting a biphasic response to long-term training may be explained by differences in study groups and exercise programs. (C) 2010 Growth Hormone Research Society. Published by Elsevier Ltd. All rights reserved.
C1 [Gregory, Sara M.; Headley, Samuel A.; Coughlin, Mary Ann; Sullivan, Sheila] Springfield Coll, Exercise Sci Program, Dept Exercise Sci & Sports Studies, Springfield, MA 01109 USA.
   [Germain, Michael] Pioneer Valley Dialysis Ctr, W Springfield, MA 01089 USA.
   [Flyvbjerg, Allan; Frystyk, Jan] Aarhus Univ Hosp, Inst Clin Med, Med Res Labs, DK-8000 Aarhus, Denmark.
   [Milch, Charles M.] Springfield Coll, Sch Hlth Sci & Rehabil Studies, Phys Assistant Program, Springfield, MA 01109 USA.
   [Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
RP Gregory, SM (reprint author), Springfield Coll, Exercise Sci Program, Dept Exercise Sci & Sports Studies, Springfield, MA 01109 USA.
EM sgregory@spfldcol.edu
FU Baystate Medical Center
FX We would like to acknowledge the effort and commitment of the subjects
   who participated in the study, the student trainers who supervised the
   training sessions, and the staff at the Springfield College Wellness
   Center and at Western New England Renal and Transplant Associates
   (WNERTA) for their accommodation and assistance. We would like to thank
   Mrs. Lone Kvist, Elsebeth Horneman, Kirsten Nyborg, and Susanne Sorensen
   for skilled laboratory measurements with the IGF-measurements. This
   study was funded by the Baystate Medical Center Incubator Fund.
NR 28
TC 10
Z9 10
U1 1
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1096-6374
J9 GROWTH HORM IGF RES
JI Growth Horm. IGF Res.
PD FEB
PY 2011
VL 21
IS 1
BP 51
EP 56
DI 10.1016/j.ghir.2010.12.005
PG 6
WC Cell Biology; Endocrinology & Metabolism
SC Cell Biology; Endocrinology & Metabolism
GA 736EW
UT WOS:000288474500008
PM 21251861
ER

PT J
AU Cupul-Uicab, LA
   Baird, DD
   Skjaerven, R
   Saha-Chaudhuri, P
   Haug, K
   Longnecker, MP
AF Cupul-Uicab, L. A.
   Baird, D. D.
   Skjaerven, R.
   Saha-Chaudhuri, P.
   Haug, K.
   Longnecker, M. P.
TI In utero exposure to maternal smoking and women's risk of fetal loss in
   the Norwegian Mother and Child Cohort (MoBa)
SO HUMAN REPRODUCTION
LA English
DT Article
DE tobacco smoking; in utero exposure; miscarriage; pregnancy; stillbirth
ID EARLY-PREGNANCY; BIRTH-WEIGHT; HABITS; CESSATION
AB BACKGROUND: Whether in utero exposure to tobacco smoke increases a woman's risk of fetal loss later in life is unknown, though data on childhood exposure suggest an association may exist. This study evaluated the association between in utero exposure to tobacco smoke and fetal loss in the Norwegian Mother and Child Cohort Study (MoBa), which enrolled similar to 40% of the pregnant women in Norway from 1999 to 2008.
   METHODS: Information on exposure to tobacco smoke in utero, the woman's own smoking behavior during pregnancy and other factors was obtained by a questionnaire completed at similar to 17 weeks of gestation. Subsequent late miscarriage (fetal death < 20 weeks) and stillbirth (fetal death >= 20 weeks) were ascertained from the Norwegian Medical Birth Registry. This analysis included 76 357 pregnancies (MoBa data set version 4.301) delivered by the end of 2008; 59 late miscarriages and 270 stillbirths occurred. Cox proportional hazards models were fit for each outcome and for all fetal deaths combined.
   RESULTS: The adjusted hazard ratio (HR) of late miscarriage was 1.23 [95% confidence interval (CI), 0.72-2.12] in women with exposure to maternal tobacco smoke in utero when compared with non-exposed women. The corresponding adjusted HR for stillbirths was 1.11 (95% CI, 0.85-1.44) and for all fetal deaths combined, it was 1.12 (95% CI, 0.89-1.43).
   CONCLUSIONS: The relatively wide CI around the HR for miscarriage reflected the limited power to detect an association, due to enrollment around 17 weeks of gestation. However, for in utero exposure to tobacco smoke and risk of stillbirth later in life, where the study power was adequate, our data provided little support for an association.
C1 [Cupul-Uicab, L. A.; Baird, D. D.; Longnecker, M. P.] NIEHS, Epidemiol Branch, NIH, DHHS,USA, Res Triangle Pk, NC 27709 USA.
   [Skjaerven, R.] Univ Bergen, Sect Med Stat, Bergen, Norway.
   [Skjaerven, R.] Univ Bergen, Med Birth Registry Norway, Bergen, Norway.
   [Saha-Chaudhuri, P.] NIEHS, Biostat Branch, NIH, DHHS,USA, Res Triangle Pk, NC 27709 USA.
   [Haug, K.] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
RP Cupul-Uicab, LA (reprint author), NIEHS, Epidemiol Branch, NIH, DHHS,USA, MD A3-05,111 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM cupuluicabl@niehs.nih.gov
RI Saha Chaudhuri, Paramita/F-3835-2010; Baird, Donna/D-5214-2017; CUPUL
   UICAB, LEA/C-8699-2014; 
OI Baird, Donna/0000-0002-5544-2653; CUPUL UICAB, LEA/0000-0001-6190-4474;
   Longnecker, Matthew/0000-0001-6073-5322; Saha Chaudhuri,
   Paramita/0000-0003-1987-320X
FU Intramural Research Program; National Institute of Environmental Health
   Sciences (NIEHS); National Institutes of Health (NIH); Norwegian
   Ministry of Health [ES044008]; National Institute of Environmental
   Health Sciences, NIH/NIEHS [N01-ES-85433]; NIH/NINDS [1 UO1 NS
   047537-01]; Norwegian Research Council/FUGE [151918/S10]
FX This study was supported, in part, by the Intramural Research Program,
   the National Institute of Environmental Health Sciences (NIEHS) and the
   National Institutes of Health (NIH). The Norwegian Mother and Child
   Cohort Study is supported by the Norwegian Ministry of Health, contract
   ES044008 with the National Institute of Environmental Health Sciences,
   NIH/NIEHS (grant no N01-ES-85433), NIH/NINDS (grant no. 1 UO1 NS
   047537-01) and the Norwegian Research Council/FUGE (grant no.
   151918/S10).
NR 40
TC 6
Z9 6
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
J9 HUM REPROD
JI Hum. Reprod.
PD FEB
PY 2011
VL 26
IS 2
BP 458
EP 465
DI 10.1093/humrep/deq334
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA 709VW
UT WOS:000286470500025
PM 21147823
ER

PT J
AU Wang, F
   Tian, Z
   Sadler, BM
AF Wang, Feng
   Tian, Zhi
   Sadler, Brian M.
TI Weighted Energy Detection for Noncoherent Ultra-Wideband Receiver Design
SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS
LA English
DT Article
DE Ultra-wideband (UWB); weighted energy detection; channel estimation;
   synchronization; decision direction
AB For ultra-wideband (UWB) impulse radios, noncoherent energy detectors are motivated for their simple circuitry and effective capture of multipath energy. A major performance-degrading factor in energy detection is the noise floor, which is aggravated for low-duty-cycle UWB signals with a large time-bandwidth product. In this paper, weighted energy detection (WED) techniques are developed for effective noise suppression. The received signal is processed by a set of parallel integrators, each corresponding to a different integration time-window within a symbol period. The outputs of these integrators are weighted and linearly combined to generate decision statistics, while the weights are determined by the signal power collected from the corresponding integrators to improve the effective signal to noise ratio. The WED principle is applied to all phases of receiver processing, including signal detection, timing synchronization and data demodulation. For each phase, the optimal linear detector parameters, including decision thresholds and weighting coefficients, are derived analytically. Simulations show that the proposed noncoherent WED receiver enhances the bit-error-rate performance compared to conventional energy detectors.
C1 [Tian, Zhi] Michigan Technol Univ, Dept Elect & Comp Engn, Houghton, MI 49931 USA.
   [Sadler, Brian M.] USA, Res Lab, Adelphi, MD USA.
RP Wang, F (reprint author), Arizona State Univ, Tempe, AZ 85287 USA.
EM fwang28@asu.edu; ztian@mtu.edu
FU U.S. NSF [CCR-0238174]
FX Part of this work was presented at the IEEE SPAWC Conf. in 2005. Z. Tian
   was supported by U.S. NSF Grant No. CCR-0238174.
NR 21
TC 28
Z9 31
U1 0
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1536-1276
J9 IEEE T WIREL COMMUN
JI IEEE Trans. Wirel. Commun.
PD FEB
PY 2011
VL 10
IS 2
BP 710
EP 720
DI 10.1109/TWC.2010.120310.101390
PG 11
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA 721BB
UT WOS:000287325300037
ER

PT J
AU Lim, J
   Hong, J
   Chen, WNW
   Weerasooriya, T
AF Lim, Jaeyoung
   Hong, Jihye
   Chen, Weinong W.
   Weerasooriya, Tusit
TI Mechanical response of pig skin under dynamic tensile loading
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Kolsky bar; SHTB; Dynamic tension; Mechanical response; Porcine skin
ID HOPKINSON PRESSURE BAR; PULSE SHAPING TECHNIQUES; SOFT MATERIALS; SOLIDS
AB Uniaxial tensile experiments were performed on pig skin to investigate the tensile stress strain response at both quasi-static and dynamic rates of deformation. A Kolsky tension bar, also called a split Hopkinson tension bar (SHTB), was modified to conduct the dynamic experiments. Semiconductor strain gages were used to measure the low levels of the transmitted signal from pig skin. A pulse shaper technique was used for generating a suitable incident pulse to ensure stress equilibrium and approximate constant strain rate in the specimen of a thin skin sheet wrapped around the ends of the bars for minimizing radial inertia. In order to investigate the strain-rate effect over a wide range of strain rates, quasi-static tests were also performed. The experimental results show that pig skin exhibits rate-sensitive, orthotropic, and non-linear behavior. The response along the spine direction is stiffer at lower rate but is less rate sensitive than the perpendicular direction. An Ogden model with two material constants is adopted to describe the rate-sensitive tensile behavior of the pig skin. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Lim, Jaeyoung; Hong, Jihye; Chen, Weinong W.] Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA.
   [Lim, Jaeyoung; Hong, Jihye; Chen, Weinong W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA.
   [Weerasooriya, Tusit] USA, Res Lab, Aberdeen Proving Ground, MD 20005 USA.
RP Chen, WNW (reprint author), Purdue Univ, Sch Aeronaut Astronaut, W Lafayette, IN 47907 USA.
EM wchen@purdue.edu
NR 24
TC 24
Z9 25
U1 3
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD FEB-MAR
PY 2011
VL 38
IS 2-3
BP 130
EP 135
DI 10.1016/j.ijimpeng.2010.09.003
PG 6
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA 701LX
UT WOS:000285820500008
ER

PT J
AU Fuller, CD
   Nijkamp, J
   Duppen, JC
   Rasch, CRN
   Thomas, CR
   Wang, SJ
   Okunieff, P
   Jones, WE
   Baseman, D
   Patel, S
   Demandante, CGN
   Harris, AM
   Smith, BD
   Katz, AW
   McGann, C
   Harper, JL
   Chang, DT
   Smalley, S
   Marshall, DT
   Goodman, KA
   Papanikolaou, N
   Kachnic, LA
AF Fuller, Clifton D.
   Nijkamp, Jasper
   Duppen, Joop C.
   Rasch, Coen R. N.
   Thomas, Charles R., Jr.
   Wang, Samuel J.
   Okunieff, Paul
   Jones, William E., III
   Baseman, Daniel
   Patel, Shilpen
   Demandante, Carlo G. N.
   Harris, Anna M.
   Smith, Benjamin D.
   Katz, Alan W.
   McGann, Camille
   Harper, Jennifer L.
   Chang, Daniel T.
   Smalley, Stephen
   Marshall, David T.
   Goodman, Karyn A.
   Papanikolaou, Niko
   Kachnic, Lisa A.
CA Radiation Oncology Comm SW Oncolog
TI PROSPECTIVE RANDOMIZED DOUBLE-BLIND PILOT STUDY OF SITE-SPECIFIC
   CONSENSUS ATLAS IMPLEMENTATION FOR RECTAL CANCER TARGET VOLUME
   DELINEATION IN THE COOPERATIVE GROUP SETTING
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Article
DE Target volume delineation; Cooperative group; Conformal radiotherapy;
   Atlas; Consensus guideline
ID HEAD-AND-NECK; CONFORMAL RADIOTHERAPY; RADIATION ONCOLOGY; LUNG-CANCER;
   IMAGE REGISTRATION; OBSERVER VARIATION; BREAST-CANCER; DUMMY RUN;
   DEFINITION; IMPACT
AB Purpose: Variations in target volume delineation represent a significant hurdle in clinical trials involving conformal radiotherapy. We sought to determine the effect of a consensus guideline-based visual atlas on contouring the target volumes.
   Methods and Materials: A representative case was contoured (Scan 1) by 14 physician observers and a reference expert with and without target volume delineation instructions derived from a proposed rectal cancer clinical trial involving conformal radiotherapy. The gross tumor volume (GTV), and two clinical target volumes (CTVA, including the internal iliac, presacral, and perirectal nodes, and CTVB, which included the external iliac nodes) were contoured. The observers were randomly assigned to receipt (Group A) or nonreceipt (Group B) of a consensus guideline and atlas for anorectal cancers and then instructed to recontour the same case/images (Scan 2). Observer variation was analyzed volumetrically using the conformation number (CN, where CN = 1 equals total agreement).
   Results: Of 14 evaluable contour sets (1 expert and 7 Group A and 6 Group B observers), greater agreement was found for the GTV (mean CN, 0.75) than for the CTVs (mean CN, 0.46-0.65). Atlas exposure for Group A led to significantly increased interobserver agreement for CTVA (mean initial CN, 0.68, after atlas use, 0.76; p = .03) and increased agreement with the expert reference (initial mean CN, 0.58; after atlas use, 0.69; p = .02). For the GTV and CTVB, neither the interobserver nor the expert agreement was altered after atlas exposure.
   Conclusion: Consensus guideline atlas implementation resulted in a detectable difference in interobserver agreement and a greater approximation of expert volumes for the CTVA but not for the GTV or CTVB in the specified case. Visual atlas inclusion should be considered as a feature in future clinical trials incorporating conformal RT. (C) 2011 Elsevier Inc.
C1 [Fuller, Clifton D.; Jones, William E., III; Baseman, Daniel; Demandante, Carlo G. N.; Harris, Anna M.; Papanikolaou, Niko] Univ Texas San Antonio, Hlth Sci Ctr San Antonio, Dept Radiat Oncol, San Antonio, TX USA.
   [Fuller, Clifton D.; Papanikolaou, Niko] Univ Texas San Antonio, Grad Div Radiol Sci, Dept Radiol, San Antonio, TX USA.
   [Fuller, Clifton D.; Thomas, Charles R., Jr.; Wang, Samuel J.] Oregon Hlth & Sci Univ, Dept Radiat Med, Portland, OR 97201 USA.
   [Nijkamp, Jasper; Duppen, Joop C.; Rasch, Coen R. N.] Netherlands Canc Inst, Dept Radiotherapy, Amsterdam, Netherlands.
   [Okunieff, Paul; Katz, Alan W.] Univ Rochester, Dept Radiat Oncol, Rochester, NY USA.
   [Patel, Shilpen] Univ Washington, Med Ctr, Dept Radiat Oncol, Seattle, WA 98195 USA.
   [Demandante, Carlo G. N.] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA.
   [Smith, Benjamin D.] Univ Texas Houston, MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA.
   [Smith, Benjamin D.; McGann, Camille] Brooke Army Med Ctr, Dept Radiat Oncol, San Antonio, TX USA.
   [Harper, Jennifer L.; Marshall, David T.] Med Univ S Carolina, Dept Radiat Oncol, Charleston, SC 29425 USA.
   [Chang, Daniel T.] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA.
   [Smalley, Stephen] Univ Kansas, Dept Radiat Oncol, Kansas City, KS USA.
   [Smalley, Stephen] Radiat Oncol Ctr Olathe, Olathe, KS USA.
   [Goodman, Karyn A.] Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY 10021 USA.
   [Kachnic, Lisa A.] Boston Univ, Med Ctr, Dept Radiat Oncol, Boston, MA USA.
   [Kachnic, Lisa A.] Massachusetts Gen Hosp, Ctr Canc, Boston, MA USA.
RP Fuller, CD (reprint author), Univ Texas San Antonio, Hlth Sci Ctr San Antonio, Dept Radiat Oncol, 7703 Floyd Curl Dr,MSC7889, San Antonio, TX USA.
EM fullercd@uthscsa.edu
OI Nijkamp, Jasper/0000-0001-7523-5881; Fuller,
   Clifton/0000-0002-5264-3994; Smith, Benjamin/0000-0001-7866-1093
FU National Institutes of Health/National Institute of Biomedical Imaging
   and Bioengineering [5T32EB000817-04]; European Society for Therapeutic
   Radiology and Oncology; Society for Imaging Informatics in Medicine
FX C. D. Fuller was supported by a training grant from the National
   Institutes of Health/National Institute of Biomedical Imaging and
   Bioengineering, "Multidisciplinary Training Program in Human Imaging"
   (Grant 5T32EB000817-04), a Technology Transfer Grant from the European
   Society for Therapeutic Radiology and Oncology, and the Product Support
   Development Grant from the Society for Imaging Informatics in Medicine.
NR 42
TC 22
Z9 22
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PD FEB 1
PY 2011
VL 79
IS 2
BP 481
EP 489
DI 10.1016/j.ijrobp.2009.11.012
PG 9
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA 709OW
UT WOS:000286451000023
PM 20400244
ER

PT J
AU Mernild, SH
   Liston, GE
   Hiemstra, CA
   Christensen, JH
   Stendel, M
   Hasholt, B
AF Mernild, Sebastian H.
   Liston, Glen E.
   Hiemstra, Christopher A.
   Christensen, Jens H.
   Stendel, Martin
   Hasholt, Bent
TI Surface Mass Balance and Runoff Modeling Using HIRHAM4 RCM at
   Kangerlussuaq (Sondre Stromfjord), West Greenland, 1950-2080
SO JOURNAL OF CLIMATE
LA English
DT Article
ID RESOLUTION REGIONAL CLIMATE; COMPLEX SNOW DISTRIBUTIONS; ICE-SHEET;
   SOUTHEAST GREENLAND; AMMASSALIK ISLAND; MELT; SIMULATIONS; PERSPECTIVE;
   GLACIER; SYSTEM
AB A regional atmospheric model, the HIRHAM4 regional climate model (RCM) using boundary conditions front the ECHAM5 atmosphere-ocean general circulation model (AOGCM), was downscaled to a 500-m gridcell increment using SnowModel to simulate 131 yr (1950-2080) of hydrologic cycle evolution in west Greenland's Kangerlussuaq drainage. Projected changes in the Greenland Ice Sheet (GrIS) surface mass balance (SMB) and runoff are relevant for potential hydropower production and prediction of ecosystem changes in sensitive Kangerlussuaq Fjord systems. Mean annual surface air temperatures and precipitation in the Kangerlussuaq area were simulated to increase by 3.4 degrees C and 95 mm water equivalent (w.eq.), respectively, between 1950 and 2080. The local Kangerlussuaq warming was less than the average warming of 4.8 degrees C simulated for the entire GrIS. The Kangerlussuaq SMB loss increased by an average of 0.3 km(3) because of a 0.4 km(3) rise in precipitation, 0.1 km(3) rise in evaporation and sublimation, and 0.6 km(3) gain in runoff (1950-2080). By 2080, the spring runoff season begins approximately three weeks earlier. The average modeled SMB and runoff is approximately -0.1 and 1.2 km(3) yr(-1), respectively, indicating that similar to 10% of the Kangerlussuaq runoff is explained by the GrIS SMB net loss. The cumulative net volume loss (1950-2080) front SMB was 15.9 km(3), and runoff was 151.2 km(3) w.eq. This runoff volume is expected to have important hydrodynamic and ecological impacts on the stratified salinity in the Kangerlussuaq Fjord and on the transport of freshwater to the ocean.
C1 [Mernild, Sebastian H.] Los Alamos Natl Lab, Climate Ocean & Sea Ice Modeling Grp, Computat Phys & Methods CCS 2, Los Alamos, NM 87545 USA.
   [Liston, Glen E.; Hiemstra, Christopher A.] Colorado State Univ, Cooperat Inst Res Atmosphere, Ft Collins, CO 80523 USA.
   [Hiemstra, Christopher A.] Cold Reg Res & Engn Lab, Fairbanks, AK USA.
   [Christensen, Jens H.; Stendel, Martin] Danish Meteorol Inst, Danish Climate Ctr, Copenhagen, Denmark.
   [Christensen, Jens H.; Stendel, Martin] Greenland Climate Res Ctr, Nuuk, Greenland.
   [Hasholt, Bent] Univ Copenhagen, Dept Geog & Geol, Copenhagen, Denmark.
RP Mernild, SH (reprint author), Los Alamos Natl Lab, Climate Ocean & Sea Ice Modeling Grp, Computat Phys & Methods CCS 2, Mail Stop B296, Los Alamos, NM 87545 USA.
EM mernild@lanl.gov
RI Christensen, Jens/C-4162-2013
OI Christensen, Jens/0000-0002-9908-8203
FU U.S. Department of Energy's Office of Science; National Nuclear Security
   Administration of the United States; Kommissionen for Videnskabelige
   Undersogelser i Gronland (KVUG) Kangerlussuaq (CRIK) [272-07-0645,
   2138-08-0003]; Greenland Climate Research Centre in Nuuk, Greenland
FX Very special thanks to the three anonymous reviewers for their
   insightful critique of this article. This work was supported by the
   Climate Change Prediction Program of the U.S. Department of Energy's
   Office of Science. Los Alamos National Laboratory is operated under the
   auspices of the National Nuclear Security Administration of the United
   States. This work was also supported by the Kommissionen for
   Videnskabelige Undersogelser i Gronland (KVUG) project Climatic Record
   in Kangerlussuaq (CRIK; Grant 272-07-0645) and by KVUG (Grant
   2138-08-0003). Christensen and Stendel acknowledge the financial support
   from the Greenland Climate Research Centre in Nuuk, Greenland. Very
   special thanks to Dr. William H. Lipscomb of Los Alamos National
   Laboratory for his insightful critique of this article. Thanks are given
   to the Cooperative Institute for Research in the Atmosphere, Colorado
   State University, for hosting the first author during November and
   December 2009.
NR 69
TC 22
Z9 23
U1 3
U2 8
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0894-8755
EI 1520-0442
J9 J CLIMATE
JI J. Clim.
PD FEB 1
PY 2011
VL 24
IS 3
BP 609
EP 623
DI 10.1175/2010JCLI3560.1
PG 15
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 734AB
UT WOS:000288304500003
ER

PT J
AU Paolino, K
   Sande, J
   Perez, E
   Loechelt, B
   Jantausch, B
   Painter, W
   Anderson, M
   Tippin, T
   Lanier, ER
   Fry, T
   DeBiasi, RL
AF Paolino, Kris
   Sande, Jane
   Perez, Evelio
   Loechelt, Brett
   Jantausch, Barbara
   Painter, Wendy
   Anderson, Margaret
   Tippin, Tim
   Lanier, E. Randall
   Fry, Terry
   DeBiasi, Roberta L.
TI Eradication of disseminated adenovirus infection in a pediatric
   hematopoietic stem cell transplantation recipient using the novel
   antiviral agent CMX001
SO JOURNAL OF CLINICAL VIROLOGY
LA English
DT Article
DE Adenovirus; Stem-cell transplantation; Antiviral therapy
ID MARROW TRANSPLANTS; CIDOFOVIR; DISEASE; BLOOD
AB Adenovirus infection is a serious and often fatal complication in hematopoietic stem cell transplant patients. There are currently no FDA-approved therapies for adenovirus infection, with only anecdotal, off-label uses described for a variety of anti-viral agents or immune therapies. We report the first case of successful eradication of disseminated adenovirus infection by the novel antiviral agent CMX001 in a severely immunocompromised pediatric stem cell transplant recipient following failure to respond to intravenous cidofovir. Complete clinical and virologic response was documented; virologic and pharmacokinetic data are reported. CMX001 is a promising new oral antiviral agent under development for the prophylaxis and treatment of severe infections caused by double-stranded DNA viruses including adenovirus in immunocompromised patients. (C) 2010 Elsevier B.V. All rights reserved.
C1 [DeBiasi, Roberta L.] George Washington Univ, Childrens Natl Med Ctr, Sch Med, Div Infect Dis, Washington, DC 20010 USA.
   [Paolino, Kris] Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20307 USA.
   [Sande, Jane; Perez, Evelio; Loechelt, Brett; Fry, Terry] Childrens Natl Med Ctr, Div Blood & Marrow Transplantat, Washington, DC 20010 USA.
   [Painter, Wendy; Anderson, Margaret; Tippin, Tim; Lanier, E. Randall] Chimerix Inc, Durham, NC USA.
   [DeBiasi, Roberta L.] George Washington Univ, Dept Pediat, Sch Med, Washington, DC 20010 USA.
RP DeBiasi, RL (reprint author), George Washington Univ, Childrens Natl Med Ctr, Sch Med, Div Infect Dis, 111 Michigan Ave NW,WW 3-5, Washington, DC 20010 USA.
EM rdebiasi@cnmc.org
RI Paolino, Kristopher/G-1859-2012; 
OI Perez-Albuerne, Evelio/0000-0001-6159-9510
NR 15
TC 37
Z9 40
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1386-6532
J9 J CLIN VIROL
JI J. Clin. Virol.
PD FEB
PY 2011
VL 50
IS 2
BP 167
EP 170
DI 10.1016/j.jcv.2010.10.016
PG 4
WC Virology
SC Virology
GA 711KP
UT WOS:000286590600017
PM 21094081
ER

PT J
AU Ubol, S
   Suksatu, A
   Modhiran, N
   Sangma, C
   Thitithanyanont, A
   Fukuda, M
   Juthayothin, T
AF Ubol, Sukathida
   Suksatu, Ampa
   Modhiran, Naphak
   Sangma, Chak
   Thitithanyanont, Arunee
   Fukuda, Mark
   Juthayothin, Tada
TI Intra-host diversities of the receptor-binding domain of stork
   faeces-derived avian H5N1 viruses and its significance as predicted by
   molecular dynamic simulation
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID INFLUENZA-VIRUS; EVOLUTIONARY DYNAMICS; POSITIVE SELECTION;
   HEMAGGLUTININ
AB Virus evolution facilitates the emergence of viruses with unpredictable impacts on human health. This study investigated intra-host variations of the receptor-binding domain (RBD) of the haemagglutinin (HA) gene of the avian H5N1 viruses obtained from the 2004 and 2005 epidemics. The results showed that the mutation frequency of the RBD ranged from 0.3 to 0.6 %. The mutations generated one consensus and several minor populations. The consensus population of the 2004 epidemic was transmitted to the 2005 outbreak with increased frequency (39 and 45%, respectively). Molecular dynamics simulation was applied to predict the significance of the variants. The results revealed that the consensus sequence (E218K/V248I) interacted unstably with sialic acid (SA) with an alpha 2,6 linkage (SA alpha 2,6Gal). Although the mutated K140R/E218K1V2481 and Y191C/E218K/V2481 sequences decreased the HA binding capacity to alpha 2,3-linked SA, they were shown to bind a2,6-linked SA with increased affinity. Moreover, the substitutions at aa 140 and 191 were positive-selection sites. These data suggest that the K140R and Y191C mutations may represent a step towards human adaptation of the avian H5N1 virus.
C1 [Ubol, Sukathida; Suksatu, Ampa; Modhiran, Naphak; Thitithanyanont, Arunee] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand.
   [Sangma, Chak] Kasetsart Univ, Fac Sci, Dept Chem, Bangkok, Thailand.
   [Fukuda, Mark] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
   [Juthayothin, Tada] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Bangkok, Thailand.
RP Ubol, S (reprint author), Mahidol Univ, Fac Sci, Dept Microbiol, 272 Rama 6 Rd, Bangkok 10400, Thailand.
EM scsul@mahidol.ac.th
FU National Science and Technology Development Agency
   [BT-B-01-MG-14-50092]; National Institute of Health; National Institute
   of Allergy and Infectious Diseases [YI-AI-5026-01]; Thailand Graduate
   Institute of Science and Technology (TGIST)
FX This work was supported by research grants from the National Science and
   Technology Development Agency (BT-B-01-MG-14-50092) to S. U., from the
   National Institute of Health and the National Institute of Allergy and
   Infectious Diseases (YI-AI-5026-01) to M. F. and from the Thailand
   Graduate Institute of Science and Technology (TGIST) to A. S., who
   received a scholarship and financial support during graduate study.
NR 27
TC 3
Z9 3
U1 1
U2 2
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
   BERKS, ENGLAND
SN 0022-1317
J9 J GEN VIROL
JI J. Gen. Virol.
PD FEB
PY 2011
VL 92
BP 307
EP 314
DI 10.1099/vir.0.025973-0
PN 2
PG 8
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA 725IQ
UT WOS:000287638800008
PM 20980529
ER

PT J
AU Thomas, SJ
AF Thomas, Stephen J.
TI The Necessity and Quandaries of Dengue Vaccine Development
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Editorial Material
ID FLAVIVIRUS-NAIVE ADULTS; T-LYMPHOCYTE RESPONSES; CELL-MEDIATED-IMMUNITY;
   US MILITARY PERSONNEL; ATTENUATED DENGUE; HEMORRHAGIC-FEVER;
   VIRUS-VACCINE; MEXICO BORDER; DISEASE PATHOGENESIS; HUMAN VOLUNTEERS
C1 Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand.
RP Thomas, SJ (reprint author), Armed Forces Res Inst Med Sci, US Army Med Component, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM stephen.thomas@afrims.org
NR 100
TC 25
Z9 28
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD FEB 1
PY 2011
VL 203
IS 3
BP 299
EP 303
DI 10.1093/infdis/jiq060
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 711SN
UT WOS:000286611800002
PM 21208919
ER

PT J
AU Maas, AIR
   Harrison-Felix, CL
   Menon, D
   Adelson, PD
   Balkin, T
   Bullock, R
   Engel, DC
   Gordon, W
   Langlois-Orman, J
   Lew, HL
   Robertson, C
   Temkin, N
   Valadka, A
   Verfaellie, M
   Wainwright, M
   Wright, DW
   Schwab, K
AF Maas, Andrew I. R.
   Harrison-Felix, Cynthia L.
   Menon, David
   Adelson, P. David
   Balkin, Tom
   Bullock, Ross
   Engel, Doortje C.
   Gordon, Wayne
   Langlois-Orman, Jean
   Lew, Henry L.
   Robertson, Claudia
   Temkin, Nancy
   Valadka, Alex
   Verfaellie, Mieke
   Wainwright, Mark
   Wright, David W.
   Schwab, Karen
TI Standardizing Data Collection in Traumatic Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE clinical studies; common data elements; data coding; data collection;
   standardization; traumatic brain injury
ID COMMON DATA ELEMENTS; WORKING GROUP; RECOMMENDATIONS; MODERATE;
   CLASSIFICATION; RELIABILITY; THERAPIES; VALIDITY; CARE
AB Collaboration among investigators, centers, countries, and disciplines is essential to advancing the care for traumatic brain injury (TBI). It is thus important that we "speak the same language.'' Great variability, however, exists in data collection and coding of variables in TBI studies, confounding comparisons between and analysis across different studies. Randomized controlled trials can never address the many uncertainties concerning treatment approaches in TBI. Pooling data from different clinical studies and high-quality observational studies combined with comparative effectiveness research may provide excellent alternatives in a cost-efficient way. Standardization of data collection and coding is essential to this end. Common data elements (CDEs) are presented for demographics and clinical variables applicable across the broad spectrum of TBI. Most recommendations represent a consensus derived from clinical practice. Some recommendations concern novel approaches, for example assessment of the intensity of therapy in severely injured patients. Up to three levels of detail for coding data elements were developed: basic, intermediate, and advanced, with the greatest level of detail attained in the advanced version. More detailed codings can be collapsed into the basic version. Templates were produced to summarize coding formats, explanation of choices, and recommendations for procedures. Endorsement of the recommendations has been obtained from many authoritative organizations. The development of CDEs for TBI should be viewed as a continuing process; as more experience is gained, refinement and amendments will be required. This proposed process of standardization will facilitate comparative effectiveness research and encourage high-quality meta-analysis of individual patient data.
C1 [Maas, Andrew I. R.] Univ Antwerp Hosp, Antwerp, Belgium.
   [Harrison-Felix, Cynthia L.] Craig Hosp, Englewood, CO USA.
   [Menon, David] Univ Cambridge, Cambridge, England.
   [Adelson, P. David] Phoenix Childrens Neurosci Inst, Phoenix, AZ USA.
   [Balkin, Tom] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Washington, DC 20307 USA.
   [Bullock, Ross] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Engel, Doortje C.] Univ Heidelberg Hosp, Heidelberg, Germany.
   [Gordon, Wayne] Mt Sinai Sch Med, New York, NY USA.
   [Langlois-Orman, Jean] USA, Inst Surg Res, San Antonio, TX USA.
   [Lew, Henry L.] Virginia Commonwealth Univ, Dept Phys Med & Rehabil, Richmond, VA USA.
   [Lew, Henry L.] Virginia Commonwealth Univ, Def & Vet Brain Injury Ctr, Richmond, VA USA.
   [Robertson, Claudia] Baylor Coll Med, Houston, TX 77030 USA.
   [Temkin, Nancy] Univ Washington, Seattle, WA 98195 USA.
   [Valadka, Alex] Seton Brain & Spine Inst, Austin, TX USA.
   [Verfaellie, Mieke] Boston VA Hlth Care Syst, Boston, MA USA.
   [Verfaellie, Mieke] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Wainwright, Mark] Northwestern Univ, Chicago, IL 60611 USA.
   [Wright, David W.] Emory Univ, Sch Med, Atlanta, GA USA.
   [Schwab, Karen] Def & Vet Brain Injury Ctr, Washington, DC USA.
RP Maas, AIR (reprint author), Univ Antwerp Hosp, Dept Neurosurg, Wilrijkstr 10, B-2650 Edegem, Belgium.
EM andrew.maas@uza.be
RI Maas, Andrew/C-5584-2013; Wright, David/F-1209-2013; 
OI Maas, Andrew/0000-0003-1612-1264; Wright, David/0000-0002-7145-9105;
   Verfaellie, Mieke/0000-0001-5535-4584
FU National Institutes of Health (NIH)-NINDS [NS 042691]; National
   Institute on Disability and Rehabilitation Research; Department of
   Veterans Affairs; Defense and Veterans Brain Injury Center; Defense
   Centers of Excellence
FX The meetings and activities of the working group "Demographics and
   Clinical Assessment'' were supported by funding in the context of the
   interagency initiative towards "an integrated approach to Research in
   Psychological Health and Traumatic Brain Injury'' (National Institutes
   of Health (NIH)-NINDS; the National Institute on Disability and
   Rehabilitation Research; the Department of Veterans Affairs; the Defense
   and Veterans Brain Injury Center; and the Defense Centers of
   Excellence). The development of CDEs was further supported by a
   supplemental grant from NIH-NINDS (NS 042691). The authors greatly
   acknowledge the input and advice obtained from these international
   experts: Giuseppe Citerio (Italy), Peter Hutchinson (U.K.), Bertil
   Romner (Denmark), Juan Sahuquillo (Spain), Franco Servadei (Italy), and
   Nino Stocchetti (Italy). We are grateful to Nele Kleisz and Anne-Claire
   van Harderwijk for administrative support in developing the common data
   elements and templates, and in preparing this manuscript.
NR 32
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U2 5
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
J9 J NEUROTRAUM
JI J. Neurotrauma
PD FEB
PY 2011
VL 28
IS 2
BP 177
EP 187
DI 10.1089/neu.2010.1617
PG 11
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA 719UE
UT WOS:000287234700002
PM 21162610
ER

PT J
AU Patrician, PA
   Loan, L
   McCarthy, M
   Fridman, M
   Donaldson, N
   Bingham, M
   Brosch, LR
AF Patrician, Patricia A.
   Loan, Lori
   McCarthy, Mary
   Fridman, Moshe
   Donaldson, Nancy
   Bingham, Mona
   Brosch, Laura R.
TI The Association of Shift-Level Nurse Staffing With Adverse Patient
   Events
SO JOURNAL OF NURSING ADMINISTRATION
LA English
DT Article
ID ACUTE-CARE; OUTCOMES; QUALITY
AB Objective: The objective of this study was to demonstrate the association between nurse staffing and adverse events at the shift level.
   Background: Despite a growing body of research linking nurse staffing and patient outcomes, the relationship of staffing to patient falls and medication errors remains equivocal, possibly due to dependence on aggregated data.
   Methods: Thirteen military hospitals participated in creating a longitudinal nursing outcomes database to monitor nurse staffing, patient falls and medication errors, and other outcomes. Unit types were analyzed separately to stratify patient and nurse staffing characteristics. Bayesian hierarchical logistic regression modeling was used to examine associations between staffing and adverse events.
   Results: RN skill mix, total nursing care hours, and experience, measured by a proxy variable, were associated with shift-level adverse events.
   Conclusions: Consideration must be given to nurse staffing and experience levels on every shift.
C1 [Patrician, Patricia A.] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL 35294 USA.
   [McCarthy, Mary] Madigan Army Med Ctr, Nursing Res Serv, Tacoma, WA 98431 USA.
   [Fridman, Moshe] AMF Consulting Inc, Los Angeles, CA USA.
   [Donaldson, Nancy] Univ Calif San Francisco, Sch Nursing, Ctr Res & Innovat Patient Care, San Francisco, CA 94143 USA.
   [Bingham, Mona] Brooke Army Med Ctr, Nursing Res Serv, Ft Sam Houston, TX 78234 USA.
   [Brosch, Laura R.] USA, ORP, Med Res & Mat Command, Frederick, MD USA.
   [Brosch, Laura R.] USA, ORP Human Res Protect Off, Med Res & Mat Command, Frederick, MD USA.
RP Patrician, PA (reprint author), Univ Alabama Birmingham, Sch Nursing, NB324,1530 3rd Ave S, Birmingham, AL 35294 USA.
EM ppatrici@uab.edu
FU Uniformed Services University of the Health Sciences [N03-P07]
FX This project was funded by the TriService Nursing Research Program,
   Uniformed Services University of the Health Sciences (grant N03-P07);
   however, the information or content and conclusions do not necessarily
   represent the official position or policy of, nor should any official
   endorsement be inferred by, the TriService Nursing Research Program,
   Uniformed Services University of the Health Sciences, the Department of
   Defense, or the US Government.
NR 20
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U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0002-0443
J9 J NURS ADMIN
JI J. Nurs. Adm.
PD FEB
PY 2011
VL 41
IS 2
BP 64
EP 70
DI 10.1097/NNA.0b013e31820594bf
PG 7
WC Nursing
SC Nursing
GA 711IT
UT WOS:000286584700005
PM 21266884
ER

PT J
AU Figueiredo, TH
   Qashu, F
   Apland, JP
   Aroniadou-Anderjaska, V
   Souza, AP
   Braga, MFM
AF Figueiredo, Taiza H.
   Qashu, Felicia
   Apland, James P.
   Aroniadou-Anderjaska, Vassiliki
   Souza, Adriana P.
   Braga, Maria F. M.
TI The GluK1 (GluR5)
   Kainate/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
   Receptor Antagonist LY293558 Reduces Soman-Induced Seizures and
   Neuropathology
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID ORGANOPHOSPHORUS NERVE AGENTS; KAINATE RECEPTORS; STATUS EPILEPTICUS;
   BASOLATERAL AMYGDALA; GABA(A) RECEPTORS; ANTICONVULSANT TREATMENT; RAT;
   INTERNEURONS; HIPPOCAMPUS; TOPIRAMATE
AB The possibility of mass exposure to nerve agents by a terrorist attack necessitates the availability of antidotes that can be effective against nerve agent toxicity even when administered at a relatively long latency after exposure, because medical assistance may not be immediately available. Nerve agents induce status epilepticus (SE), which can cause brain damage or death. Antagonists of kainate receptors that contain the GluK1 (formerly known as GluR5) subunit (GluK1Rs) are emerging as a new potential treatment for SE and epilepsy from animal research, whereas clinical trials to treat pain have shown that the GluK1/alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 [(3S, 4aR, 6R, 8aR)-6-[2(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid] is safe and well tolerated. Therefore, we tested whether LY293558 is effective against soman-induced seizures and neuropathology, when administered 1 h after soman exposure, in rats. LY293558 stopped seizures induced by soman and reduced the total duration of SE, monitored by electroencephalographic recordings within a 24 h-period after exposure. In addition, LY293558 prevented neuronal loss in the basolateral amygdala (BLA) and the CA1 hippocampal area on both days 1 and 7 after soman exposure and reduced neuronal degeneration in the CA1, CA3, and hilar hippocampal regions, entorhinal cortex, amygdala, and neocortex on day 1 after exposure and in the CA1, CA3, amygdala, and neocortex on day 7 after exposure. It also prevented the delayed loss of glutamic acid decarboxylase-67 immuno-stained BLA interneurons on day 7 after exposure. LY293558 is a potential new emergency treatment for nerve agent exposure that can be expected to be effective against seizures and brain damage even with late administration.
C1 [Figueiredo, Taiza H.; Qashu, Felicia; Aroniadou-Anderjaska, Vassiliki; Souza, Adriana P.; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
   [Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA.
   [Apland, James P.] USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Aberdeen, MD USA.
RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM mbraga@usuhs.mil
FU CounterACT Program; National Institutes of Health Office of the Director
   through the National Institute of Neurological Disorders and Stroke
   [U01-NS058162-01]; Defense Threat Reduction Agency-Joint Science and
   Technology Office, Medical Science and Technology Division
   [1.E0021_07_US_C]
FX This work was supported by the CounterACT Program, National Institutes
   of Health Office of the Director through the National Institute of
   Neurological Disorders and Stroke [Award U01-NS058162-01], and the
   Defense Threat Reduction Agency-Joint Science and Technology Office,
   Medical Science and Technology Division [Grant 1.E0021_07_US_C].
NR 43
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U2 2
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD FEB
PY 2011
VL 336
IS 2
BP 303
EP 312
DI 10.1124/jpet.110.171835
PG 10
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA 707TA
UT WOS:000286309800002
PM 20962029
ER

PT J
AU Nousiainen, T
   Munoz, O
   Lindqvist, H
   Mauno, P
   Videen, G
AF Nousiainen, Timo
   Munoz, Olga
   Lindqvist, Hannakaisa
   Mauno, Paivi
   Videen, Gorden
TI Light scattering by large Saharan dust particles: Comparison of modeling
   and experimental data for two samples
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Light scattering; Mineral dust; Modeling; Measurements; Ray-optics
   approximation
ID RAY OPTICS APPROXIMATION; MINERAL DUST; RADIATIVE PROPERTIES;
   AEROSOL-PARTICLES; ICE CRYSTALS; MATRIX; SPHEROIDS
AB Light scattering by large mineral-dust particles with small-scale surface roughness is investigated by comparing model simulations with laboratory-measured scattering Matrices of two distinct dust samples collected from the Sahara desert. The samples have been chosen on the basis of their large effective radii, and the simulations are based on their measured size distributions. Size parameters larger than about 30 are modeled using a modified ray-optics model RODS (Ray optics with diffuse and specular interactions), while smaller particles are simulated with a T-matrix model. RODS allows us to mimic the surface roughness of large dust particles by covering the particle surface by a thin layer of external scatterers with specific single-scattering properties. The Gaussian-random-sphere geometry is used for the shapes of large dust particles. Small particles are modeled as an axial-ratio distribution of spheroids with smooth surfaces. One of the samples consists wholly of large particles and its scattering matrix can be reproduced very well by the RODS model, except for the phase function. The incorporation of wavelength-scale roughness is, however, necessary for good fits. The other sample, consisting of both small and large particles, proves more challenging to match with simulations. The analysis indicates, however, that the difficulties arise at least partially from the small-particle contribution, while RODS results are consistent with the measurements. Further, the results imply that the agreement with measurements would improve if roughness could also be accounted for in the small-particle simulations. Overall, the RODS method seems promising for modeling the optical properties of mineral-dust particles much larger than the wavelength. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Nousiainen, Timo; Lindqvist, Hannakaisa; Mauno, Paivi] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland.
   [Munoz, Olga] CSIC, Inst Astrofis Andalucia, E-18080 Granada, Spain.
   [Videen, Gorden] USA, Res Lab, Adelphi, MD 20783 USA.
RP Nousiainen, T (reprint author), Univ Helsinki, Dept Phys, POB 48, FI-00014 Helsinki, Finland.
EM timo.nousiainen@helsinki.fi
RI Nousiainen, Timo/A-7982-2008; 
OI Nousiainen, Timo/0000-0002-6569-9815; Munoz, Olga/0000-0002-5138-3932
FU Academy of Finland [125180, 121482]
FX This work was supported by the Academy of Finland (Contracts 125180 and
   121482). K. Muinonen and M. Mishchenko are acknowledged for making
   available the light-scattering models used in this study. We are also
   thankful for the constructive comments given by the two anonymous
   referees.
NR 38
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U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD FEB
PY 2011
VL 112
IS 3
BP 420
EP 433
DI 10.1016/j.jqsrt.2010.09.003
PG 14
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA 716HP
UT WOS:000286960000005
ER

PT J
AU Boonnak, K
   Dambach, KM
   Donofrio, GC
   Tassaneetrithep, B
   Marovich, MA
AF Boonnak, Kobporn
   Dambach, Kaitlyn M.
   Donofrio, Gina C.
   Tassaneetrithep, Boonrat
   Marovich, Mary A.
TI Cell Type Specificity and Host Genetic Polymorphisms Influence
   Antibody-Dependent Enhancement of Dengue Virus Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HUMAN DENDRITIC CELLS; BLOOD MONONUCLEAR-CELLS; FC-GAMMA RECEPTORS; ROSS
   RIVER VIRUS; HEMORRHAGIC-FEVER; T-CELLS; PROMOTER POLYMORPHISMS;
   CYTOKINE PRODUCTION; DISEASE SEVERITY; HUMAN-MONOCYTES
AB Antibody-dependent enhancement (ADE) is implicated in severe, usually secondary, dengue virus (DV) infections. Preexisting heterotypic antibodies, via their Fc-gamma receptor (Fc gamma R) interactions, may increase disease severity through enhanced target cell infection. Greater numbers of infected target cells may contribute to higher viremia and excess cytokine levels often observed in severe disease. Monocytes, macrophages, and immature and mature dendritic cells (DC) are considered major cellular targets of DV. Apheresis of multiple donors allowed isolation of autologous primary myeloid target cell types for head-to-head comparison of infection rates, viral output, and cytokine production under direct infection (without antibody) or ADE conditions (with antibody). All studied cell types except immature DC supported ADE. All cells undergoing ADE secreted proinflammatory cytokines (interleukin-6 [IL-6] and tumor necrosis factor alpha [TNF-alpha]) at enhancement titers, but distinct cell-type-specific patterns were observed for other relevant proteins (alpha/beta interferon [IFN-alpha/beta] and IL-10). Macrophages produced type I interferons (IFN-alpha/beta) that were modulated by ADE. Mature DC mainly secreted IFN-beta. Interestingly, only monocytes secreted IL-10, and only upon antibody-enhanced infection. While ADE infection rates were remarkably consistent in monocytes (10 to 15%) across donors, IL-10 protein levels varied according to previously described regulatory single nucleotide polymorphisms (SNPs) in the IL-10 promoter region. The homozygous GCC haplotype was associated with high-level IL-10 secretion, while the ACC and ATA haplotypes produced intermediate and low levels of IL-10, respectively. Our data suggest that ADE effects are cell type specific, are influenced by host genetics, and, depending on relative infection rates, may further contribute to the complexity of DV pathogenesis.
C1 [Marovich, Mary A.] Uniformed Serv Univ Hlth Sci, Dept Med, Div Retrovirol, Dept Vaccine R&D,Walter Reed Army Inst Res, Rockville, MD 20850 USA.
   [Boonnak, Kobporn; Dambach, Kaitlyn M.; Donofrio, Gina C.; Tassaneetrithep, Boonrat; Marovich, Mary A.] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD 20850 USA.
   [Marovich, Mary A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
   [Tassaneetrithep, Boonrat] Mahidol Univ, Off Res & Dev, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand.
RP Marovich, MA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Div Retrovirol, Dept Vaccine R&D,Walter Reed Army Inst Res, 13 Taft Ct,Suite 200, Rockville, MD 20850 USA.
EM mmarovich@hivresearch.org
FU Pediatric Dengue Vaccine Initiative; Army Medical Research and Materiel
   Command [DAMD17-98-2-8007]; Henry M. Jackson Foundation for the
   Advancement of Military Medicine [DAMD17-98-2-8007]; Military Infectious
   Disease Research Program [DAMD17-98-2-8007]
FX This work was supported by the Pediatric Dengue Vaccine Initiative and
   in part by the cooperative agreement DAMD17-98-2-8007 between the U.S.
   Army Medical Research and Materiel Command, the Henry M. Jackson
   Foundation for the Advancement of Military Medicine, and the Military
   Infectious Disease Research Program.
NR 59
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U1 0
U2 11
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
J9 J VIROL
JI J. Virol.
PD FEB
PY 2011
VL 85
IS 4
BP 1671
EP 1683
DI 10.1128/JVI.00220-10
PG 13
WC Virology
SC Virology
GA 709EP
UT WOS:000286420900025
PM 21123382
ER

PT J
AU Kim, HS
   Mall, S
   Ghoshal, A
AF Kim, Heung Soo
   Mall, Shankar
   Ghoshal, Anindya
TI Two-Dimensional and Three-Dimensional Finite Element Analysis of Finite
   Contact Width on Fretting Fatigue
SO MATERIALS TRANSACTIONS
LA English
DT Article
DE fretting fatigue; contact; stick-slip; finite element analysis;
   three-dimensional effects; traction distribution; hybrid layer method
ID RECIPROCATING SLIDING CONDITIONS; CRACK INITIATION; TI-6AL-4V; STRESSES;
   BEHAVIOR; MECHANICS; WEAR; PAD
AB Three-dimensional effects of finite contact width fretting fatigue were investigated using the combination of full three-dimensional finite element model and two-dimensional plane strain finite element model, named as a hybrid layer method. Free edge boundary effect in finite contact width fretting fatigue problem required full three-dimensional finite element analysis to obtain accurate stress state and relative displacement in contact zone. To save the computational cost with sufficient accuracy, traction distributions obtained from coarse three-dimensional finite element analysis was applied to the two-dimensional plane strain finite element model. The key idea of this hybrid layer method was that traction distributions converged faster than the stresses. The proposed hybrid layer method predicted the free edge boundary effects of finite contact width fretting fatigue less than eight percent error bound and reduce the execution time to 5 percent of three-dimensional submodeling technique. [doi: 10.2320/matertrans.M2010268]
C1 [Kim, Heung Soo] Dongguk Univ Seoul, Dept Mech Robot & Energy Eng, Seoul 100715, South Korea.
   [Mall, Shankar] USAF, Dept Aeronaut & Astronaut, Inst Technol, Wright Patterson AFB, OH 45433 USA.
   [Ghoshal, Anindya] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Kim, HS (reprint author), Dongguk Univ Seoul, Dept Mech Robot & Energy Eng, Seoul 100715, South Korea.
EM heungsoo@dongguk.edu
RI Kim, Heung Soo /F-6611-2011
OI Kim, Heung Soo /0000-0001-7057-5174
FU Dongguk University
FX This work was supported by the Dongguk University Research Fund of 2010.
NR 25
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U1 1
U2 15
PU JAPAN INST METALS
PI SENDAI
PA 1-14-32, ICHIBANCHO, AOBA-KU, SENDAI, 980-8544, JAPAN
SN 1345-9678
EI 1347-5320
J9 MATER TRANS
JI Mater. Trans.
PD FEB
PY 2011
VL 52
IS 2
BP 147
EP 154
DI 10.2320/matertrans.M2010268
PG 8
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
   Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA 745SS
UT WOS:000289186800006
ER

PT J
AU Ersal, T
   Brudnak, M
   Salvi, A
   Stein, JL
   Filipi, Z
   Fathy, HK
AF Ersal, Tulga
   Brudnak, Mark
   Salvi, Ashwin
   Stein, Jeffrey L.
   Filipi, Zoran
   Fathy, Hosam K.
TI Development and model-based transparency analysis of an
   Internet-distributed hardware-in-the-loop simulation platform
SO MECHATRONICS
LA English
DT Article
DE Real-time hardware-in-the-loop simulation; Internet-distributed
   simulation; Transparency
ID BILATERAL TELEOPERATION; TIME-DELAY; SYSTEMS
AB This paper summarizes efforts to integrate, for the first time, two geographically dispersed hardware-in-the-loop simulation setups over the Internet in an observer-free way for an automotive application. The two setups are the engine-in-the-loop simulation setup at the University of Michigan (UM) in Ann Arbor, MI, USA, and the driver-in-the-loop ride motion simulator at the US Army Tank-Automotive Research, Development and Engineering Center (TARDEC) in Warren, MI, USA. The goal of such integration is to increase the fidelity of experiments and to enable concurrent geographically dispersed systems engineering. First, experiments with the actual hardware are presented. The concept of transparency is discussed, and the infeasibility of performing a baseline experiment with ideally integrated hardware is presented as a challenge to characterize the transparency of the experimental setup. This motivates the second half of the paper, in which a model-based approach is taken to analyze the transparency of the system. The conclusion is that an observer-free solution is feasible for integrating the two pieces of hardware over the Internet in a transparent manner, even if the nominal delay is increased by four times. It is also found that different signals in the system can exhibit different levels of transparency. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Ersal, Tulga; Salvi, Ashwin; Stein, Jeffrey L.; Filipi, Zoran; Fathy, Hosam K.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
   [Brudnak, Mark] US Army Tank Automot Res, Ctr Dev & Engn, Warren, MI USA.
RP Fathy, HK (reprint author), Univ Michigan, Dept Mech Engn, 1231 Beal Ave, Ann Arbor, MI 48109 USA.
EM hfathy@umich.edu
RI Ersal, Tulga/B-5169-2008
OI Ersal, Tulga/0000-0002-6811-8529
FU ILIR program at TARDEC
FX This work was supported by a grant from the ILIR program at TARDEC to
   Dr. Hosam K. Fathy. The authors gratefully acknowledge this support, and
   would also like to thank Fernando Tavares and Rajit Johri for their help
   with the experiments.
NR 58
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U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0957-4158
J9 MECHATRONICS
JI Mechatronics
PD FEB
PY 2011
VL 21
IS 1
BP 22
EP 29
DI 10.1016/j.mechatronics.2010.08.002
PG 8
WC Automation & Control Systems; Computer Science, Artificial Intelligence;
   Engineering, Electrical & Electronic; Engineering, Mechanical
SC Automation & Control Systems; Computer Science; Engineering
GA 724AI
UT WOS:000287548100003
ER

PT J
AU Becker, CR
   Apperson, S
   Morris, CJ
   Gangopadhyay, S
   Currano, LJ
   Churaman, WA
   Stoldt, CR
AF Becker, Collin R.
   Apperson, Steven
   Morris, Christopher J.
   Gangopadhyay, Shubhra
   Currano, Luke J.
   Churaman, Wayne A.
   Stoldt, Conrad R.
TI Galvanic Porous Silicon Composites for High-Velocity Nanoenergetics
SO NANO LETTERS
LA English
DT Article
DE Porous silicon; nanoenergetics; nanoparticles; MEMS
ID ENERGETIC MATERIALS; PORE STRUCTURE; FUEL-CELLS; REACTIVITY; LAYER
AB Porous silicon (PS) films similar to 65-95 mu thick composed of pores with diameters less than 3 run-were fabricated using a galvanic etching approach that does not require an external power, supply. A highly reactive, nano-energetic composite was then created by impregnating the nanoscale pores with the strong oxidizer, sodium perchlorate (NaClO4). The combustion propagation velocity of the energetic composite was measured using microfabricated diagnostic devices in conjunction with high-speed optical imaging up to 930000 frames per second. Combustion, velocities averaging 3050 m/s were observed for PS films with specific surface areas of similar to 840 m(2)/g and porosities of 65-67%.
C1 [Becker, Collin R.; Stoldt, Conrad R.] Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
   [Becker, Collin R.; Morris, Christopher J.; Currano, Luke J.; Churaman, Wayne A.] USA, Res Lab, Adelphi, MD 20783 USA.
   [Apperson, Steven; Gangopadhyay, Shubhra] Univ Missouri, Dept Elect & Comp Engn, Columbia, MO 65211 USA.
RP Stoldt, CR (reprint author), Univ Colorado, Dept Mech Engn, Boulder, CO 80309 USA.
EM Conrad.stoldt@colorado.edu
FU Department of Defense; U.S. Army Research Office [W911NF-06-1-0342]
FX Collin Becker is funded by a Department of Defense SMART fellowship and
   is grateful to the U.S. Army Research Lab for hosting his research.
   Funding for galvanic PS research was provided under U.S. Army Research
   Office Grant No. W911NF-06-1-0342. The authors thank Brian Isaacson for
   assistance in wafer processing.
NR 27
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Z9 47
U1 1
U2 42
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
J9 NANO LETT
JI Nano Lett.
PD FEB
PY 2011
VL 11
IS 2
BP 803
EP 807
DI 10.1021/nl104115u
PG 5
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 717LZ
UT WOS:000287049100083
PM 21182311
ER

PT J
AU Goff, BJ
   Walker, GA
   Gloystein, DM
AF Goff, Brandon Jesse
   Walker, Geoffrey A.
   Gloystein, David M.
TI Combat Soldier Loads: Implications for Cumulative Overuse Injuries and
   Chronic Pain
SO PM&R
LA English
DT Editorial Material
ID MEDICAL ASPECTS; HEAVY LOADS; CARRIAGE
C1 [Goff, Brandon Jesse] Brooke Army Med Ctr, Outpatient Pain Serv, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA.
   [Gloystein, David M.] Carl R Darnall Army Med Ctr, Dept Orthopaed & Rehabil, Ft Hood, TX USA.
EM brandon.goff@us.army.mil
OI Goff, Brandon/0000-0002-5665-9395
NR 6
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1934-1482
J9 PM&R
JI PM&R
PD FEB
PY 2011
VL 3
IS 2
BP 183
EP 185
DI 10.1016/j.pmrj.2010.10.024
PG 3
WC Rehabilitation; Sport Sciences
SC Rehabilitation; Sport Sciences
GA 961AW
UT WOS:000305437300018
PM 21333959
ER

PT J
AU Dux, MP
   Huang, JC
   Barent, R
   Inan, M
   Swanson, ST
   Sinha, J
   Ross, JT
   Smith, LA
   Smith, TJ
   Henderson, I
   Meagher, MM
AF Dux, Michael P.
   Huang, Jicai
   Barent, Rick
   Inan, Mehmet
   Swanson, S. Todd
   Sinha, Jayanta
   Ross, John T.
   Smith, Leonard A.
   Smith, Theresa J.
   Henderson, Ian
   Meagher, Michael M.
TI Purification of a recombinant heavy chain fragment C vaccine candidate
   against botulinum serotype C neurotoxin [rBoNTC(H-c)] expressed in
   Pichia pastoris
SO PROTEIN EXPRESSION AND PURIFICATION
LA English
DT Article
DE Pichia pastoris; Botulinum toxin vaccine; Protein purification;
   Recombinant
ID PROTEOLYTIC DEGRADATION; SCALE-UP; FERMENTATION; TOXIN; PREVENTION
AB A purification process for the manufacture of a recombinant C-terminus heavy chain fragment from botulinum neurotoxin serotype C [rBoNTC(H-c)] a potential vaccine candidate has been defined and successfully scaled-up The rBoNTC(H-c) was produced intracellularly in Pichia pastoris X-33 using a three step fermentation process i e glycerol batch phase a glycerol fed-batch phase to achieve high cell densities followed by a methanol induction phase The rBoNTC(H-c) was captured from the soluble protein fraction of cell lysate using hydrophobic charge induction chromatography (HCIC MEP HyperCel (TM)) and then further purified using a CM 650M ion exchange chromatography step followed by a polishing step using HCIC once again Method development at the bench scale was achieved using 5-100 mL columns and the process was performed at the pilot scale using 06-1 6 L columns in preparation for technology transfer to cGMP manufacturing The process yielded approximately 2 5 g of rBoNTC(H-c)/kg wet cell weight (WCW) at the bench scale and 1 6 g rBoNTC(H-c)/kg WCW at the pilot scale The purified rBoNTC(H-c) was stable for at least 3 months at 5 and -80 degrees C as determined by reverse phase-HPLC and SDS-PAGE and was stable for 24 months at -80 degrees C based on mouse potency bioassay N-Terminal amino acid sequencing confirmed that the N terminus of the purified rBoNTC(H-c) was intact (C) 2010 Elsevier Inc All rights reserved
C1 [Dux, Michael P.; Huang, Jicai; Barent, Rick; Inan, Mehmet; Swanson, S. Todd; Sinha, Jayanta; Meagher, Michael M.] Univ Nebraska, BPDF, Coll Engn, Lincoln, NE 68588 USA.
   [Dux, Michael P.] Novartis Anim Hlth US Inc, Larchwood, IA 51241 USA.
   [Huang, Jicai] Nektar Therapeut, Huntsville, AL 35806 USA.
   [Barent, Rick] Intervet, Elkhorn, NE 68022 USA.
   [Inan, Mehmet] Alder Pharmaceut, Bothell, WA 98011 USA.
   [Henderson, Ian] A CSC Co, DynPort Vaccine Co DVC LLC, Frederick, MD 21702 USA.
   [Smith, Leonard A.] USA, Med Res & Materiel Command, Ft Detrick, MD 21702 USA.
   [Smith, Theresa J.] USAMRIID, Integrated Toxicol Div, Frederick, MD 21702 USA.
   [Henderson, Ian] Emergent Prod Dev Gaithersburg Inc, Gaithersburg, MD 20879 USA.
RP Meagher, MM (reprint author), Univ Nebraska, BPDF, Coll Engn, 304B Othmer Hall, Lincoln, NE 68588 USA.
RI Inan, Mehmet/D-9890-2012; 
OI Inan, Mehmet/0000-0003-1806-7927
FU National Institute of Allergy and Infectious Disease [1U01 AI
   056514-01]; The Medical Research and Materiel Command [DAMD17-02-C-0107]
FX This publication was made possible by Contract Number 1U01 AI 056514-01
   from National Institute of Allergy and Infectious Disease and its
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the National Institute of
   Allergy and Infectious Disease This work was also supported by The
   Medical Research and Materiel Command Contract No DAMD17-02-C-0107 We
   would like to thank the BPDF s Quality Control Group and Analytical
   Methods Laboratory for sample analysis through out this project Also we
   would like to thank the BPDF s Purification Development Laboratory staff
   for process development support throughout this project
NR 26
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U1 0
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-5928
J9 PROTEIN EXPRES PURIF
JI Protein Expr. Purif.
PD FEB
PY 2011
VL 75
IS 2
BP 177
EP 185
DI 10.1016/j.pep.2010.09.016
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Biotechnology & Applied Microbiology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 692BM
UT WOS:000285126500010
PM 20933089
ER

PT J
AU Wu, XL
   Youssef, KM
   Koch, CC
   Mathaudhu, SN
   Kecskes, LJ
   Zhu, YT
AF Wu, X. L.
   Youssef, K. M.
   Koch, C. C.
   Mathaudhu, S. N.
   Kecskes, L. J.
   Zhu, Y. T.
TI Deformation twinning in a nanocrystalline hcp Mg alloy
SO SCRIPTA MATERIALIA
LA English
DT Article
DE Twinning; Nanocrystalline; hcp; Mg; Alloying
ID STACKING-FAULT ENERGY; MOLECULAR-DYNAMICS SIMULATION; HIGH DUCTILITY;
   METALS; TWINS; MAGNESIUM; MECHANISM; STRENGTH; ALUMINUM; COPPER
AB Nanocrystalline (nc) hexagonal close-packed (hcp) metals are rarely observed to deform by twinning, which is contrary to face-centered cubic metals. Here we report that, after alloying Mg with 10 at% Ti, deformation twins are observed in an nc Mg Ti alloy processed by mechanical attrition. The formation of deformation twins is attributed to the alloying effect, which may change the energy path for twinning. These results point to a promising approach to design nc hcp alloys for superior mechanical properties. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Youssef, K. M.; Koch, C. C.; Zhu, Y. T.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
   [Wu, X. L.] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
   [Mathaudhu, S. N.; Kecskes, L. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Zhu, YT (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
EM ytzhu@ncsu.edu
RI Zhu, Yuntian/B-3021-2008; Mathaudhu, Suveen/B-4192-2009; Youssef,
   Khaled/F-4629-2010; Kecskes, Laszlo/F-6880-2014
OI Zhu, Yuntian/0000-0002-5961-7422; Youssef, Khaled/0000-0001-9850-5223;
   Kecskes, Laszlo/0000-0002-1342-3729
FU NSFC [11072243, 10721202]; 973 Project [2010CB631004, 2007CB613700];
   U.S. Army Research Office [W911NF-09-1-0427]; Army Research Laboratory
   [W911QX-08-C-0083]
FX X.L.W. acknowledges the support of NSFC Grant Nos. 11072243, 10721202,
   973 Project Grant Nos. 2010CB631004 and 2007CB613700. Other coauthors
   were supported by the U.S. Army Research Office (W911NF-09-1-0427) and
   the Army Research Laboratory (W911QX-08-C-0083).
NR 34
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U1 7
U2 83
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6462
J9 SCRIPTA MATER
JI Scr. Mater.
PD FEB
PY 2011
VL 64
IS 3
BP 213
EP 216
DI 10.1016/j.scriptamat.2010.10.024
PG 4
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
   Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
   Metallurgical Engineering
GA 694UA
UT WOS:000285323300001
ER

PT J
AU De Lucia, FC
   Gottfried, JL
AF De Lucia, Frank C., Jr.
   Gottfried, Jennifer L.
TI Influence of variable selection on partial least squares discriminant
   analysis models for explosive residue classification
SO SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY
LA English
DT Article
DE Laser-induced breakdown spectroscopy LIBS; Explosives; Partial least
   squares discriminant analysis; Multivariate analysis
ID INDUCED BREAKDOWN SPECTROSCOPY; NITROGEN-RICH; MULTIVARIATE-ANALYSIS;
   IDENTIFICATION; SPECTRA; EXAMPLE; SAMPLES; SALTS
AB Using a series of thirteen organic materials that includes novel high-nitrogen energetic materials, conventional organic military explosives, and benign organic materials, we have demonstrated the importance of variable selection for maximizing residue discrimination with partial least squares discriminant analysis (PLS-DA). We built several PLS-DA models using different variable sets based on laser induced breakdown spectroscopy (LIBS) spectra of the organic residues on an aluminum substrate under an argon atmosphere. The model classification results for each sample are presented and the influence of the variables on these results is discussed. We found that using the whole spectra as the data input for the PLS-DA model gave the best results. However, variables due to the surrounding atmosphere and the substrate contribute to discrimination when the whole spectra are used, indicating this may not be the most robust model. Further iterative testing with additional validation data sets is necessary to determine the most robust model. Published by Elsevier B.V.
C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.] USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA.
RP De Lucia, FC (reprint author), USA, Res Lab, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA.
EM frank.delucia@us.army.mil
RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012
NR 34
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U1 4
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0584-8547
J9 SPECTROCHIM ACTA B
JI Spectroc. Acta Pt. B-Atom. Spectr.
PD FEB
PY 2011
VL 66
IS 2
BP 122
EP 128
DI 10.1016/j.sab.2010.12.007
PG 7
WC Spectroscopy
SC Spectroscopy
GA 747OI
UT WOS:000289328900004
ER

PT J
AU Loose, B
   Schlosser, P
   Perovich, D
   Ringelberg, D
   Ho, DT
   Takahashi, T
   Richter-Menge, J
   Reynolds, CM
   McGillis, WR
   Tison, JL
AF Loose, B.
   Schlosser, P.
   Perovich, D.
   Ringelberg, D.
   Ho, D. T.
   Takahashi, T.
   Richter-Menge, J.
   Reynolds, C. M.
   McGillis, W. R.
   Tison, J-L.
TI Gas diffusion through columnar laboratory sea ice: implications for
   mixed-layer ventilation of CO2 in the seasonal ice zone
SO TELLUS SERIES B-CHEMICAL AND PHYSICAL METEOROLOGY
LA English
DT Article
ID SULFUR-HEXAFLUORIDE; PHASE DIFFUSION; VADOSE ZONE; WATER; COEFFICIENT;
   SEAWATER; OXYGEN; SOIL; SIMULATIONS; SOLUBILITY
AB Gas diffusion through the porous microstructure of sea ice represents a pathway for ocean-atmosphere exchange and for transport of biogenic gases produced within sea ice. We report on the experimental determination of the bulk gas diffusion coefficients, D, for oxygen (O-2) and sulphur hexafluoride (SF6) through columnar sea ice under constant ice thickness conditions for ice surface temperatures between -4 and -12 degrees C. Profiles of SF6 through the ice indicate decreasing gas concentration from the ice/water interface to the ice/air interface, with evidence for solubility partitioning between gas-filled and liquid-filled pore spaces. On average, D-SF6 was 1.3 x 10(-4) cm(2) s(-1) (+/- 40%) and was 3.9 x 10(-5) cm(2) s(-1) (+/- 41%). The preferential partitioning of SF6 to the gas phase, which is the dominant diffusion pathway produced the greater rate of SF6 diffusion. Comparing these estimates of D with an existing estimate of the air-sea gas transfer through leads indicates that ventilation of the mixed layer by diffusion through sea ice may be negligible, compared to air-sea gas exchange through fractures in the ice pack, even when the fraction of open water is less than 1%.
C1 [Loose, B.; Schlosser, P.; Takahashi, T.; McGillis, W. R.] Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA.
   [Loose, B.; Schlosser, P.; Takahashi, T.] Columbia Univ, Dept Earth & Environm Sci, Palisades, NY 10964 USA.
   [Loose, B.] Woods Hole Oceanog Inst, Dept Marine Chem & Geochem, Woods Hole, MA 02543 USA.
   [Schlosser, P.; McGillis, W. R.] Columbia Univ, Dept Earth & Environm Engn, New York, NY 10027 USA.
   [Perovich, D.; Ringelberg, D.; Richter-Menge, J.; Reynolds, C. M.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
   [Ho, D. T.] Univ Hawaii Manoa, Dept Oceanog, Honolulu, HI 96822 USA.
   [Tison, J-L.] Univ Libre Bruxelles, Lab Glaciol, B-1050 Brussels, Belgium.
RP Loose, B (reprint author), Columbia Univ, Lamont Doherty Earth Observ, 61 Route 9W, Palisades, NY 10964 USA.
EM brice@whoi.edu
RI Ho, David/A-3154-2011; Schlosser, Peter/C-6416-2012; Tison,
   Jean-Louis/F-4065-2015
OI Ho, David/0000-0002-0944-6952; Schlosser, Peter/0000-0002-6514-4203;
   Tison, Jean-Louis/0000-0002-9758-3454
FU Climate Center at the Lamont-Doherty Earth Observatory; NSF [OPP
   01-25523/ANT 04-40825]
FX We would like to thank Bruce Elder and Chris Polashenski for their
   technical support of this work at CRREL. Bill Smethie and Eugene Gorman
   contributed to the design of the SF<INF>6</INF> sampling and analysis
   procedures. Thanks to David Cole for help and advice in photographing
   sea ice thin sections and for letting us use his microscope. We
   gratefully acknowledge the insightful comments and suggestions of two
   reviewers; Rik Wanninkhof and Lisa Miller. Support for this work was
   provided by the Climate Center at the Lamont-Doherty Earth Observatory,
   an NSF IGERT Fellowship to BL and NSF Grant Nos. OPP 01-25523/ANT
   04-40825 (PS). LDEO Contribution No. 7402.
NR 43
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U1 0
U2 15
PU CO-ACTION PUBLISHING
PI JARFALLA
PA RIPVAGEN 7, JARFALLA, SE-175 64, SWEDEN
SN 0280-6509
J9 TELLUS B
JI Tellus Ser. B-Chem. Phys. Meteorol.
PD FEB
PY 2011
VL 63
IS 1
BP 23
EP 39
DI 10.1111/j.1600-0889.2010.00506.x
PG 17
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA 703SP
UT WOS:000286001900002
ER

PT J
AU Mazeh, H
   Mizrahi, I
   Halle, D
   Ilyayev, N
   Stojadinovic, A
   Trink, B
   Mitrani-Rosenbaum, S
   Roistacher, M
   Ariel, I
   Eid, A
   Freund, HR
   Nissan, A
AF Mazeh, Haggi
   Mizrahi, Ido
   Halle, David
   Ilyayev, Nadia
   Stojadinovic, Alexander
   Trink, Barry
   Mitrani-Rosenbaum, Stella
   Roistacher, Marina
   Ariel, Ilana
   Eid, Ahmed
   Freund, Herbert R.
   Nissan, Aviram
TI Development of a MicroRNA-Based Molecular Assay for the Detection of
   Papillary Thyroid Carcinoma in Aspiration Biopsy Samples
SO THYROID
LA English
DT Article
ID CANCER; EXPRESSION; TUMORS; MIR-222; MIR-146; TRENDS; GROWTH
AB Background: Although thyroid nodules are common and diagnosed in over 5% of the adult population, only 5% harbor malignancy. Patients with clinically suspicious thyroid nodules need to undergo fine-needle aspiration biopsy (FNAB). The main limitation of FNAB remains indeterminate cytopathology. Only 20%-30% of the indeterminate nodules harbor malignancy, and therefore up to 80% of patients undergo unnecessary thyroidectomy. The aim of this study was to identify and validate a panel of microRNAs (miRNAs) that could serve as a platform for an FNAB-based diagnostic for thyroid neoplasms.
   Methods: The study population included 27 consecutive patients undergoing total thyroidectomy for FNAB-based papillary thyroid cancer (n = 20) and benign disorders (n = 7). Aspiration biopsy was performed from the index lesion and from the opposite lobe normal tissue in all study patients at the time of operation. RNA was extracted from all aspiration biopsy samples. Quantitative polymerase chain reaction on a panel of previously selected miRNAs was performed. Polymerase chain reaction results were compared with final histopathology. miRNA from tumor tissues was amplified using the highest value of each miRNA expression in normal tissue as a threshold for malignancy detection.
   Results: Diagnostic characteristics were most favorable for mir-221 in differentiating benign from malignant thyroid pathology. mir-221 was overexpressed in 19 patients (p < 0.0001) with a sensitive yield of 95%. Specificity, negative and positive predictive value, and accuracy of the miRNA panel were 100%, 96%, 100%, and 98%, respectively.
   Conclusions: miRNA quantification for differential diagnosis of thyroid neoplasms within aspiration biopsy samples is feasible and may improve the accuracy of FNAB cytology.
C1 [Mazeh, Haggi; Mizrahi, Ido; Halle, David; Ilyayev, Nadia; Roistacher, Marina; Eid, Ahmed; Freund, Herbert R.; Nissan, Aviram] Hadassah Hebrew Univ Med Ctr, Dept Surg, Surg Oncol Lab, IL-91240 Jerusalem, Israel.
   [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA.
   [Stojadinovic, Alexander; Nissan, Aviram] US Mil Canc Inst, Washington, DC USA.
   [Trink, Barry] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Mitrani-Rosenbaum, Stella] Hadassah Hebrew Univ Med Ctr, Goldyne Savad Inst Gene Therapy, IL-91240 Jerusalem, Israel.
   [Ariel, Ilana] Hadassah Hebrew Univ Med Ctr, Dept Pathol, IL-91240 Jerusalem, Israel.
RP Nissan, A (reprint author), Hadassah Hebrew Univ Med Ctr, Dept Surg, Surg Oncol Lab, POB 24035, IL-91240 Jerusalem, Israel.
EM anissan@hadassah.org.il
FU Israel Cancer Association [20100122]
FX The study was supported by the Israel Cancer Association (no. 20100122).
NR 29
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U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1050-7256
EI 1557-9077
J9 THYROID
JI Thyroid
PD FEB
PY 2011
VL 21
IS 2
BP 111
EP 118
DI 10.1089/thy.2010.0356
PG 8
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA 712IN
UT WOS:000286660200004
PM 21275764
ER

PT J
AU Lee, WJ
   Kim, HH
   Hwang, SM
   Park, MY
   Kim, NR
   Cho, SH
   In, TS
   Kim, JY
   Sattabongkot, J
   Sohn, Y
   Kim, H
   Lee, JK
   Lee, HW
AF Lee, Won-Ja
   Kim, Hyung-Hwan
   Hwang, Soon-Mi
   Park, Mi-Young
   Kim, Nam-Ryul
   Cho, Shin-Hyeong
   In, Tae-Sook
   Kim, Jung-Yeon
   Sattabongkot, Jetsumon
   Sohn, Youngjoo
   Kim, Hyuck
   Lee, Jong-Koo
   Lee, Hyeong-Woo
TI Detection of an antibody against Plasmodium vivax in residents of
   Gimpo-si, South Korea, using an indirect fluorescent antibody test
SO MALARIA JOURNAL
LA English
DT Article
ID POLYMERASE-CHAIN-REACTION; MALARIA; RESPONSES
AB Background: First reemerged malaria case was reported in 1993 after two decades absent in South Korea. Thereafter, Plasmodium vivax spreads out near demilitarized zone (DMZ). This study investigated the prevalence of P. vivax after the malaria transmission season in Gimpo-si where adjacent to DMZ of South Korea. An indirect fluorescent antibody test (IFAT) was performed to evaluate anti-malaria antibodies in blood samples.
   Methods: Microscopic examinations were performed to identify the presence of malaria parasites. Antibodies against P. vivax were detected using IFAT, and blood samples from antibody-positive cases were tested using a polymerase chain reaction (PCR) assay that detects malaria parasites.
   Results: A total of 5,797 blood samples were collected from residents in Gimpo-si. The positivity rate by IFAT was 2.16% (n = 125). Yangchon-myeon (3.28%) had the highest positivity rate of the seven administrative districts tested. Positivity rates increased with age (P < 0.05). Sixteen of the IFAT positive samples (12.80%, n = 125) were positive for malaria DNA according to PCR. Blood samples with an antibody titer over 1: 256 had high positivity rates in the PCR analysis (P < 0.05).
   Conclusions: These results indicate that antibody titers obtained using IFAT may provide useful information about the prevalence of P. vivax in low endemic areas and could be used to detect asymptomatic patients. Finding asymptomatic patients is important in eliminating vivax malaria in South Korea.
C1 [Lee, Hyeong-Woo] Univ Florida, Dept Pathol, Gainesville, FL 32610 USA.
   [Lee, Won-Ja; Park, Mi-Young; Kim, Nam-Ryul; Cho, Shin-Hyeong; In, Tae-Sook; Kim, Jung-Yeon] Korea Ctr Dis Control & Prevent, Natl Inst Hlth, Div Malaria & Parasit Dis, Cheongwon Gun 363951, South Korea.
   [Kim, Hyung-Hwan] Harvard Univ, Brigham & Womens Hosp, Sch Med, Vasc Med Res Unit, Cambridge, MA 02139 USA.
   [Hwang, Soon-Mi] Publ Hlth Ctr, Gimpo 415730, South Korea.
   [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
   [Sohn, Youngjoo] Sangji Univ, Coll Oriental Med, Dept Gynecol, Wonju 220717, South Korea.
   [Kim, Hyung-Hwan; Kim, Hyuck] Jungwon Univ, Int Res Ctr Biosci & Biotechnol, Goesan 367805, South Korea.
   [Lee, Jong-Koo] Minist Hlth & Welf, Korea Ctr Dis Control & Prevent, Seoul 122701, South Korea.
RP Lee, HW (reprint author), Univ Florida, Dept Pathol, J-566,1600 SW Archer Rd, Gainesville, FL 32610 USA.
EM rainlee67@yahoo.co.kr
RI LEE, Jong-koo/E-4166-2012; Lee, JongGu/B-7384-2013
FU Korean National Institute of Health, Republic of Korea
FX We are grateful to all the blood donors and the staff at the Public
   Health Center in Gimpo-si, Gyeonggi-do, Republic of Korea. This work was
   supported by an internal research grant from the Korean National
   Institute of Health, Republic of Korea.
NR 28
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U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JAN 31
PY 2011
VL 10
AR 19
DI 10.1186/1475-2875-10-19
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 740RF
UT WOS:000288811400001
PM 21281481
ER

PT J
AU Sharma, A
   Gupta, P
   Glass, PJ
   Parker, MD
   Maheshwari, RK
AF Sharma, Anuj
   Gupta, Paridhi
   Glass, Pamela J.
   Parker, Michael D.
   Maheshwari, Radha K.
TI Safety and protective efficacy of INA-inactivated Venezuelan equine
   encephalitis virus: Implication in vaccine development
SO VACCINE
LA English
DT Article
DE VEEV; Inactivation; 1,5-Iodonaphthyl-azide
ID CANDIDATE STRAIN V3526; NONHUMAN-PRIMATES; ENCEPHALOMYELITIS-VIRUS;
   STRUCTURAL INTEGRITY; ATTENUATED VACCINES; AEROSOL CHALLENGE; LIPID
   BILAYER; ANIMAL-MODELS; VEE VACCINE; LIVE
AB We have previously shown that a hydrophobic alkylating compound, 1,5-iodonaphthyl-azide (INA) can efficiently inactivate the virulent strain of Venezuelan equine encephalitis virus (VEEV), V3000 in vitro. In this study, we have evaluated the safety of INA-inactivated V3000 and V3526 and the protective efficacy of INA-inactivated V3000. INA-inactivated V3000 and V3526 did not cause disease in suckling mice. RNA isolated from the INA-inactivated V3000 and V3526 was also not infectious. Immunization of adult mice with INA-inactivated V3000 induced an anti-VEEV antibody response and protected mice from virulent VEEV challenge. The protective efficacy of INA-inactivated V3000 increased with the use of adjuvants. Results suggest that inactivation of enveloped viruses by INA may occur by two independent mechanisms and the INA-inactivated VEEV elicit a protective antibody response in mice. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Maheshwari, Radha K.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Ctr Combat Casualty & Life Sustainment Res, Bethesda, MD 20814 USA.
   [Gupta, Paridhi] Birla Inst Technol & Sci, Pilani, Rajasthan, India.
   [Glass, Pamela J.; Parker, Michael D.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
RP Maheshwari, RK (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pathol, Ctr Combat Casualty & Life Sustainment Res, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM rmaheshwari@usuhs.mil
RI Glass, Pamela/G-1170-2011; 
OI Sharma, Anuj/0000-0001-6906-190X
FU Defense Threat Reduction Agency; USAMRIID [G174QH]
FX This work was supported in part by Grants from the Defense Threat
   Reduction Agency and USAMRIID contract No. G174QH. The opinions or
   assertions contained herein are the scientific views of the authors and
   should not be construed as official or necessarily reflecting the views
   or policies of the Uniformed Services University of the Health Sciences
   or the Department of Defense, USA.
NR 41
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U1 1
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JAN 29
PY 2011
VL 29
IS 5
BP 953
EP 959
DI 10.1016/j.vaccine.2010.11.033
PG 7
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 720QS
UT WOS:000287295800014
PM 21115048
ER

PT J
AU Rao, M
   Peachman, KK
   Li, Q
   Matyas, GR
   Shivachandra, SB
   Borschel, R
   Morthole, VI
   Fernandez-Prada, C
   Alving, CR
   Rao, VB
AF Rao, Mangala
   Peachman, Kristina K.
   Li, Qin
   Matyas, Gary R.
   Shivachandra, Sathish B.
   Borschel, Richard
   Morthole, Venee I.
   Fernandez-Prada, Carmen
   Alving, Carl R.
   Rao, Venigalla B.
TI Highly effective generic adjuvant systems for orphan or poverty-related
   vaccines
SO VACCINE
LA English
DT Article
DE Adjuvants; Liposomes; Monophosphoryl lipid A; Bacteriophage T4; Anthrax;
   Non-human primates
ID ANTHRAX PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; RHESUS MACAQUES;
   BACTERIOPHAGE-T4; PROTEINS; DELIVERY; DISPLAY; STRAIN
AB Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores. Published by Elsevier Ltd.
C1 [Rao, Mangala; Peachman, Kristina K.; Matyas, Gary R.; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Rockville, MD 20850 USA.
   [Peachman, Kristina K.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
   [Li, Qin; Shivachandra, Sathish B.; Rao, Venigalla B.] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA.
   [Borschel, Richard; Fernandez-Prada, Carmen] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA.
   [Morthole, Venee I.] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA.
RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA.
EM calving@hivresearch.org; rao@cua.edu
OI Matyas, Gary/0000-0002-2074-2373
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
   Inc. [W81XWH-07-2-0067]; U.S. Department of Defense; U.S. National
   Institute of Allergy and Infectious Diseases (VBR), National Institutes
   of Health, NIAID [U01-AI056443]
FX We gratefully acknowledge the assistance of Ms. Elaine Morrison for all
   the immunizations and sera collection; Ms. Sarah McCormack for
   performing the PA-specific IgG ELISAs; Ms. Stacy Banko, and PFC Allen J.
   Mueller for assistance with all the work conducted under BSL-3
   conditions; and Ms. Zhihong Zhang for assistance with the preparation of
   bacteriophage T4 displayed antigens. We thank Drs. Stephen Leppla, John
   Clements, and Conrad Quinn for providing valuable reagents (recombinant
   PA, HLT, and AVR801 antibody). This research was supported by a
   cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson
   Foundation for the Advancement of Military Medicine, Inc., and the U.S.
   Department of Defense. The research was funded, in part, by the U.S.
   National Institute of Allergy and Infectious Diseases (VBR), National
   Institutes of Health, NIAID Grant U01-AI056443.
NR 28
TC 11
Z9 11
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
J9 VACCINE
JI Vaccine
PD JAN 29
PY 2011
VL 29
IS 5
BP 873
EP 877
DI 10.1016/j.vaccine.2010.11.049
PG 5
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA 720QS
UT WOS:000287295800003
PM 21115053
ER

PT J
AU Liang, Y
   Jensen, RE
   Pappas, DD
   Palmese, GR
AF Liang, Y.
   Jensen, R. E.
   Pappas, D. D.
   Palmese, G. R.
TI Toughening vinyl ester networks with polypropylene meso-fibers:
   Interface modification and composite properties
SO POLYMER
LA English
DT Article
DE Toughening; Surface treatments; Mechanical properties
ID DIELECTRIC BARRIER DISCHARGE; SURFACE MODIFICATION; EPOXY COMPOSITE;
   PLASMA; MECHANISMS; MORPHOLOGY; MODIFIERS; ADHESION; FRACTURE; PARTICLE
AB Polymer polymer composites comprised of vinyl ester matrices (VE) and polypropylene (PP) fiber meshes were fabricated and tested in this investigation. Results indicated that PP fibers greatly enhanced fracture toughness; however, strength of the VE was significantly reduced as voids were observed at the interface of the PP and VE. A two-step surface modification, oxygen plasma treatment followed by grafting vinyltrimethoxysilane (VTMS), was conducted on PP fibers in an effort to improve interfacial strength. Interfacial discontinuities of composites were improved after surface modification of PP. The oxygen plasma treatment added hydrophilic functional groups but caused surface roughness. Surface treatment of PP slightly increased fracture toughness of the PP-VE composite by enhancing energy absorption capacity at the interface. However, mechanical strength and modulus did not significantly increase for the composite using VTMS grafted PP fibers due to the weak fiber material. Small PP fibers with higher strength may attain the expected improvement in mechanical properties after surface treatment. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Liang, Y.; Palmese, G. R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
   [Jensen, R. E.; Pappas, D. D.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Palmese, GR (reprint author), Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
EM palmese@coe.drexel.edu
FU U. S. Army Research Laboratory under the Army Materials Center of
   Excellence [W911NF-06-2-0013]
FX The authors from Drexel University wish to acknowledge the U.S. Army
   Research Laboratory for financial support under the Army Materials
   Center of Excellence Program, contract W911NF-06-2-0013.
NR 31
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U1 1
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
J9 POLYMER
JI Polymer
PD JAN 21
PY 2011
VL 52
IS 2
BP 510
EP 518
DI 10.1016/j.polymer.2010.12.006
PG 9
WC Polymer Science
SC Polymer Science
GA 709ZM
UT WOS:000286480100036
ER

PT J
AU Juang, YT
   Rauen, T
   Wang, Y
   Ichinose, K
   Benedyk, K
   Tenbrock, K
   Tsokos, GC
AF Juang, Yuang-Taung
   Rauen, Thomas
   Wang, Ying
   Ichinose, Kunihiro
   Benedyk, Konrad
   Tenbrock, Klaus
   Tsokos, George C.
TI Transcriptional Activation of the cAMP-responsive Modulator Promoter in
   Human T Cells Is Regulated by Protein Phosphatase 2A-mediated
   Dephosphorylation of SP-1 and Reflects Disease Activity in Patients with
   Systemic Lupus Erythematosus
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ELEMENT MODULATOR; IL-2 PRODUCTION; EXPRESSION; BINDING; CREM
AB Systemic lupus erythematosus (SLE) is a complex autoimmune disease with numerous abnormalities recorded at the cellular, molecular, and genetic level. Expression of the basic leucine zipper transcription factor cAMP-responsive element modulator (CREM)alpha was reported to be abnormally increased in T cells from SLE patients. CREM alpha suppresses IL-2 and T cell receptor xi chain gene transcription by direct binding to the respective promoters. Here, we show that increased CREM expression is the result of enhanced promoter activity. DNA binding analyses reveal direct binding of transcription factor specificity protein-1 (SP-1) to the CREM promoter resulting in enhanced transcriptional activity and increased CREM expression. Protein phosphatase 2A is known to activate SP-1 through dephosphorylation at its serine residue 59. Our results show that nuclei from SLE T cells contain lower levels of Ser(59)-phosphorylated SP-1 protein and a stronger SP-1 binding to the CREM promoter. We conclude that protein phosphatase 2A accounts for enhanced SP-1 dephosphorylation at Ser(59) in SLE T cells. More importantly, CREM promoter activity mirrors reliably disease activity in SLE patients, underscoring its potential role as a biomarker for the prediction of flares in SLE patients.
C1 [Juang, Yuang-Taung; Rauen, Thomas; Ichinose, Kunihiro; Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Div Rheumatol,Sch Med, Boston, MA 02115 USA.
   [Wang, Ying] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA.
   [Benedyk, Konrad; Tenbrock, Klaus] Univ Aachen, Rhein Westfael TH, Dept Pediat, D-52074 Aachen, Germany.
RP Tsokos, GC (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Div Rheumatol,Sch Med, CLS-937,330 Brookline Ave, Boston, MA 02115 USA.
EM gtsokos@bidmc.harvard.edu
FU National Institutes of Health [AI42269, AI68787]; Deutsche
   Forschungsgemeinschaft [RA1927-1/1]; Internationales Zentrum fur
   Klinische Forschung Munster [FG5]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants AI42269 and AI68787 (to G.C.T.). This work was also
   supported by Deutsche Forschungsgemeinschaft Grant RA1927-1/1 (to T.R.)
   and Internationales Zentrum fur Klinische Forschung Munster Grant FG5
   (to K.T.).
NR 20
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U1 1
U2 1
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 21
PY 2011
VL 286
IS 3
BP 1795
EP 1801
DI 10.1074/jbc.M110.166785
PG 7
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 706BV
UT WOS:000286191500019
PM 21097497
ER

PT J
AU Hale, M
   Oyler, G
   Swaminathan, S
   Ahmed, SA
AF Hale, Martha
   Oyler, George
   Swaminathan, Subramanyam
   Ahmed, S. Ashraf
TI Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A
   Botulinum Neurotoxin Protease Activity
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID SMALL-MOLECULE INHIBITORS; MAP KINASE PATHWAY; LIGHT-CHAIN;
   INTERNALIZATION MECHANISMS; PROTEOLYTIC ACTIVITY; SNAP-25 SUBSTRATE;
   PEPTIDE DRUGS; SEROTYPE-A; T-CELLS; IDENTIFICATION
AB Botulinum neurotoxins (BoNT) are the most potent of all toxins that cause flaccid muscle paralysis leading to death. They are also potential biothreat agents. A systematic investigation of various short peptide inhibitors of the BoNT protease domain with a 17-residue peptide substrate led to arginine-arginine-glycine-cysteine having a basic tetrapeptide structure as the most potent inhibitor. When assayed in the presence of dithiothreitol (DTT), the inhibitory effect was drastically reduced. Replacing the terminal cysteine with one hydrophobic residue eliminated the DTT effect but with two hydrophobic residues made the pentapeptide a poor inhibitor. Replacing the first arginine with cysteine or adding an additional cysteine at the N terminus did not improve inhibition. When assessed using mouse brain lysates, the tetrapeptides also inhibited BoNT/A cleavage of the endogenous SNAP-25. The peptides penetrated the neuronal cell lines, N2A and BE(2)-M17, without adversely affecting metabolic functions as measured by ATP production and P-38 phosphorylation. Biological activity of the peptides persisted within cultured chick motor neurons and rat and mouse cerebellar neurons for more than 40 h and inhibited BoNT/A protease action inside the neurons in a dose- and time-dependent fashion. Our results define a tetrapeptide as the smallest peptide inhibitor in the backdrop of a large substrate protein of 200+ amino acids having multiple interaction regions with its cognate enzyme. The inhibitors should also be valuable candidates for drug development.
C1 USA, Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Integrated Toxicol Div, Ft Detrick, MD 21702 USA.
   [Oyler, George] Synapt Res LLC, Baltimore, MD 21227 USA.
   [Swaminathan, Subramanyam] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA.
RP Ahmed, SA (reprint author), USAMRIID, Integrated Toxicol Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM syed.ahmed@amedd.army.mil
FU Defense Threat Reduction Agency-Joint Science and Technology Office for
   Chemical and Biological Defense [CBS. MEDBIO.01.10.RD.002,
   JSTOCBD3.10012_06_RD_B]
FX This work was supported by the Defense Threat Reduction Agency-Joint
   Science and Technology Office for Chemical and Biological Defense Grants
   CBS. MEDBIO.01.10.RD.002 and JSTOCBD3.10012_06_RD_B (to S.A.A.).
NR 59
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U1 0
U2 8
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 21
PY 2011
VL 286
IS 3
BP 1802
EP 1811
DI 10.1074/jbc.M110.146464
PG 10
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA 706BV
UT WOS:000286191500020
PM 20961849
ER

PT J
AU Izvekov, S
AF Izvekov, Sergei
TI Towards an understanding of many-particle effects in hydrophobic
   association in methane solutions
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID TEMPERATURE-DEPENDENCE; MEAN FORCE; MOLECULAR-DYNAMICS; FREE-ENERGY;
   WATER; SIMULATION; ENTROPY; PAIR; PROTEINS; SOLUTES
AB This paper applies the multiscale coarse-graining method [S. Izvekov and G. A. Voth, J. Phys. Chem. B 109, 2469 (2005); J. Chem. Phys. 123, 134105 (2005)] to analyze many-body effects in concentrated methane solutions. Pairwise decompositions of N-particle solute-solute potentials of mean force (PMFs), and the respective solvent cavity potentials, enthalpic, entropic, and heat capacity of hydrophobic association, are calculated directly from unconstrained molecular-dynamics simulations of methane solutions at different molar fractions, with the highest being 0.055. The many-body effects in hydrophobic hydration are further studied using N-methane PMFs, which are explicitly dependent on solvent coordinates. [doi:10.1063/1.3521480]
C1 [Izvekov, Sergei] Univ Utah, Ctr Biophys Modeling & Simulat, Salt Lake City, UT 84112 USA.
   [Izvekov, Sergei] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
RP Izvekov, S (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM sergiy.izvyekov@us.army.mil
FU National Science Foundation [CHE-0719522]; Office of Naval Research
FX The author is grateful to Greg Voth, Gary Ayton, Will Noid, Ian Thorpe,
   Betsy Rice, Peter Chung, and Sarah Ham-dan for helpful discussions. The
   research was supported by the National Science Foundation (Grant No.
   CHE-0719522) and the Office of Naval Research. Computational resources
   were provided by the ERDC or the Navy DoD Supercomputing Resource
   Centers (DSRCs).
NR 55
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U1 1
U2 16
PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 0021-9606
J9 J CHEM PHYS
JI J. Chem. Phys.
PD JAN 21
PY 2011
VL 134
IS 3
AR 034104
DI 10.1063/1.3521480
PG 9
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA 709WN
UT WOS:000286472200007
PM 21261327
ER

PT J
AU Nicoll, WS
   Sacci, JB
   Rodolfo, C
   Di Giacomo, G
   Piacentini, M
   Holland, ZJM
   Doerig, C
   Hollingdale, MR
   Lanar, DE
AF Nicoll, William S.
   Sacci, John B.
   Rodolfo, Carlo
   Di Giacomo, Giuseppina
   Piacentini, Mauro
   Holland, Zoe J. M.
   Doerig, Christian
   Hollingdale, Michael R.
   Lanar, David E.
TI Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue
   transglutaminase
SO MALARIA JOURNAL
LA English
DT Article
ID HEPATOMA-CELL LINE; MULTISTAGE VACCINE CANDIDATE; CHIMERIC HUMAN LIVERS;
   MALARIA PARASITES; EXOERYTHROCYTIC DEVELOPMENT; HOST HEPATOCYTES; GAMMA
   RESPONSES; INVITRO; PROTEIN; BERGHEI
AB Background: Plasmodium falciparum sporozoites injected by mosquitoes into the blood rapidly enter liver hepatocytes and undergo pre-erythrocytic developmental schizogony forming tens of thousands of merozoites per hepatocyte. Shortly after hepatocyte invasion, the parasite starts to produce Liver Stage Antigen-1 (LSA-1), which accumulates within the parasitophorous vacuole surrounding the mass of developing merozoites. The LSA-1 protein has been described as a flocculent mass, but its role in parasite development has not been determined.
   Methods: Recombinant N-terminal, C-terminal or a construct containing both the N- and C-terminal regions flanking two 17 amino acid residue central repeat sequences (LSA-NRC) were subjected to in vitro modification by tissue transglutaminase-2 (TG2) to determine if cross-linking occurred. In addition, tissue sections of P. falciparum-infected human hepatocytes were probed with monoclonal antibodies to the isopeptide epsilon-(gamma-glutamyl) lysine cross-bridge formed by TG2 enzymatic activity to determine if these antibodies co-localized with antibodies to LSA-1 in the growing liver schizonts.
   Results: This study identified a substrate motif for (TG2) and a putative casein kinase 2 phosphorylation site within the central repeat region of LSA-1. The function of TG2 is the post-translational modification of proteins by the formation of a unique isopeptide e-(g-glutamyl) lysine cross-bridge between glutamine and lysine residues. When recombinant LSA-1 protein was crosslinked in vitro by purified TG2 in a calcium dependent reaction, a flocculent mass of protein was formed that was highly resistant to degradation. The cross-linking was not detectably affected by phosphorylation with plasmodial CK2 in vitro. Monoclonal antibodies specific to the very unique TG2 catalyzed e-lysine cross-bridge co-localized with antibodies to LSA-1 in infected human hepatocytes providing visual evidence that LSA-1 was cross-linked in vivo.
   Conclusions: While the role of LSA-1 is still unknown these results suggest that it becomes highly cross-linked which may aid in the protection of the parasite as it develops.
C1 [Nicoll, William S.; Lanar, David E.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, US Mil Malaria Vaccine Program, Silver Spring, MD 20910 USA.
   [Sacci, John B.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
   [Rodolfo, Carlo; Di Giacomo, Giuseppina; Piacentini, Mauro] Univ Roma Tor Vergata, Dept Biol, I-00173 Rome, Italy.
   [Holland, Zoe J. M.; Doerig, Christian] Univ Glasgow, Wellcome Ctr Mol Parasitol, INSERM, U609, Glasgow, Lanark, Scotland.
   [Hollingdale, Michael R.] USMMVP, Malaria Dept, NMRC, Silver Spring, MD 20910 USA.
RP Hollingdale, MR (reprint author), USMMVP, Malaria Dept, NMRC, Silver Spring, MD 20910 USA.
EM mikedc110@gmail.com
RI Piacentini, Mauro/I-2411-2016; 
OI Piacentini, Mauro/0000-0003-2919-1296; Doerig,
   Christian/0000-0002-3188-094X
FU National Research Council at WRAIR; Military Infectious Disease Research
   Program; Malaria Vaccine Initiative, PATH, through a CRADA; WRAIR; AIRC;
   PRIN; Wellcome Trust; European Union; INSERM
FX M.R.H. wishes to thank Dr. Michal Theisen, Statens Serum Institute,
   Copenhagen, Denmark, for preliminary experiments. This work was
   performed while W.S.N. held a National Research Council Research
   Associate award at WRAIR and was supported by funds from the Military
   Infectious Disease Research Program and funds provided by the Malaria
   Vaccine Initiative, PATH, through a CRADA with WRAIR and also partially
   supported from AIRC and PRIN grants to M.P. Z.J.M.H is the recipient of
   a Wellcome Trust studentship. Work in C.D.'s laboratory is supported by
   the Framework Programme 6 of the European Union (SIGMAL and ANTIMAL
   projects) and by INSERM. Bader B. Fileta, Division of Clinical
   Investigations, Walter Reed Army Medical Center, performed the MALDI-TOF
   MS measurements. The views expressed here are those of the authors and
   should not be construed to represent those of the U.S. Department of the
   Army or the U.S. Department of Defense.
NR 55
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U1 2
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD JAN 21
PY 2011
VL 10
AR 14
DI 10.1186/1475-2875-10-14
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA 740QZ
UT WOS:000288810800001
PM 21255444
ER

PT J
AU Kissner, TL
   Ruthel, G
   Alam, S
   Ulrich, RG
   Fernandez, S
   Saikh, KU
AF Kissner, Teri L.
   Ruthel, Gordon
   Alam, Shahabuddin
   Ulrich, Robert G.
   Fernandez, Stefan
   Saikh, Kamal U.
TI Activation of MyD88 Signaling upon Staphylococcal Enterotoxin Binding to
   MHC Class II Molecules
SO PLOS ONE
LA English
DT Article
ID TOLL-LIKE RECEPTOR; BRUTONS-TYROSINE KINASE; TUMOR-NECROSIS-FACTOR;
   KAPPA-B ACTIVATION; FACTOR-ALPHA GENES; HUMAN-MONOCYTES; T-CELLS;
   HLA-DR; TRANSCRIPTIONAL ACTIVATION; CYTOKINE EXPRESSION
AB Ligands binding to Toll-like receptor (TLR), interleukin 1 receptor (IL-1R), or IFN-gamma R1 are known to trigger MyD88-mediated signaling, which activates pro-inflammatory cytokine responses. Recently we reported that staphylococcal enterotoxins (SEA or SEB), which bind to MHC class II molecules on APCs and cross link T cell receptors, activate MyD88-mediated proinflammatory cytokine responses. We also reported that MyD88(-/-) mice were resistant to SE-induced toxic shock and had reduced levels of serum cytokines. In this study, we investigated whether MHC class II-SE interaction by itself is sufficient to activate MyD88 in MHC class II(+) cells and induce downstream pro-inflammatory signaling and production of cytokines such as TNF-alpha and IL-1 beta. Here we report that human monocytes treated with SEA, SEB, or anti-MHC class II monoclonal antibodies up regulated MyD88 expression, induced activation of NF-kB, and increased expression of IL-1R1 accessory protein, TNF-alpha and IL-1 beta. MyD88 immunoprecipitated from cell extracts after SEB stimulation showed a greater proportion of MyD88 phosphorylation compared to unstimulated cells indicating that MyD88 was a component of intracellular signaling. MyD88 downstream proteins such as IRAK4 and TRAF6 were also up regulated in monocytes after SEB stimulation. In addition to monocytes, primary B cells up regulated MyD88 in response to SEA or SEB stimulation. Importantly, in contrast to primary B cells, MHC class II deficient T2 cells had no change of MyD88 after SEA or SEB stimulation, whereas MHC class II-independent activation of MyD88 was elicited by CpG or LPS. Collectively, these results demonstrate that MHC class II utilizes a MyD88-mediated signaling mechanism when in contact with ligands such as SEs to induce pro-inflammatory cytokines.
C1 [Kissner, Teri L.; Ruthel, Gordon; Alam, Shahabuddin; Ulrich, Robert G.; Fernandez, Stefan; Saikh, Kamal U.] USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA.
RP Kissner, TL (reprint author), USA, Med Res Inst Infect Dis, Dept Immunol, Frederick, MD 21702 USA.
EM kamal.saikh@amedd.army.mil
FU Defense Threat Reduction Agency (DTRA) [CBM.THRTOX.03.10.RD.006]
FX This work was supported by the Defense Threat Reduction Agency (DTRA;
   WWW.jpras.us) Grant CBM.THRTOX.03.10.RD.006 to Kamal U. Saikh. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
NR 48
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U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 20
PY 2011
VL 6
IS 1
AR e15985
DI 10.1371/journal.pone.0015985
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 710OX
UT WOS:000286522200021
PM 21283748
ER

PT J
AU Stojadinovic, A
   Potter, BK
   Eberhardt, J
   Shawen, SB
   Andersen, RC
   Forsberg, JA
   Shwery, C
   Ester, EA
   Schaden, W
AF Stojadinovic, Alexander
   Potter, Benjamin Kyle
   Eberhardt, John
   Shawen, Scott B.
   Andersen, Romney C.
   Forsberg, Jonathan A.
   Shwery, Clay
   Ester, Eric A.
   Schaden, Wolfgang
TI Development of a Prognostic Naive Bayesian Classifier for Successful
   Treatment of Nonunions
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID SHOCK-WAVE THERAPY; LOWER-EXTREMITY; FRACTURES; DISABILITY
AB Background: Predictive models permitting individualized prognostication for patients with fracture nonunion are lacking. The objective of this study was to train, test, and cross-validate a Bayesian classifier for predicting fracture-nonunion healing in a population treated with extracorporeal shock wave therapy.
   Methods: Prospectively collected data from 349 patients with delayed fracture union or a nonunion were utilized to develop a naive Bayesian belief network model to estimate site-specific fracture-nonunion healing in patients treated with extracorporeal shock wave therapy. Receiver operating characteristic curve analysis and tenfold cross-validation of the model were used to determine the clinical utility of the approach.
   Results: Predictors of fracture-healing at six months following shock wave treatment were the time between the fracture and the first shock wave treatment, the time between the fracture and the surgery, intramedullary stabilization, the number of bone-grafting procedures, the number of extracorporeal shock wave therapy treatments, work-related injury, and the bone involved (p < 0.05 for all comparisons). These variables were all included in the naive Bayesian belief network model.
   Conclusions: A clinically relevant Bayesian classifier was developed to predict the outcome after extracorporeal shock wave therapy for fracture nonunions. The time to treatment and the anatomic site of the fracture nonunion significantly impacted healing outcomes. Although this study population was restricted to patients treated with shock wave therapy, Bayesian-derived predictive models may be developed for application to other fracture populations at risk for nonunion.
C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA.
   AUVA Trauma Ctr, Vienna, Austria.
   DecisionQ Corp, Washington, DC 20007 USA.
   Natl Naval Med Ctr, Bethesda, MD 20889 USA.
RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Combat Wound Initiat Program, 6900 Georgia Ave NW,Room 5C27A, Washington, DC 20307 USA.
EM alexander.stojadinovic@amedd.army.mil
RI Forsberg, Jonathan/K-2116-2012; 
OI Potter, MD, Benjamin K./0000-0002-8771-0317
FU Congressional Combat Wound Initiative; Tissue Regeneration Technologies;
   DecisionQ Corporation; Walter Reed Medical Center, Washington, DC
FX In support of their research for or preparation of this work, one or
   more of the authors received, in any one year, outside funding or grants
   in excess of $10,000 from a Congressional Combat Wound Initiative Grant
   and of less than $10,000 from Tissue Regeneration Technologies. One or
   more of the authors, or a member of his or her immediate family,
   received, in any one year, payments or other benefits in excess of
   $10,000 or a commitment or agreement to provide such benefits from a
   commercial entity (DecisionQ Corporation).; Funding for this study was
   provided by the Combat Wound Initiative Program, Walter Reed Medical
   Center, Washington, DC (a Henry M. Jackson Foundation for the
   Advancement of Military Medicine program).
NR 28
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U1 0
U2 0
PU JOURNAL BONE JOINT SURGERY INC
PI NEEDHAM
PA 20 PICKERING ST, NEEDHAM, MA 02192 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD JAN 19
PY 2011
VL 93A
IS 2
BP 187
EP 194
DI 10.2106/JBJS.I.01649
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA 714CQ
UT WOS:000286785500009
PM 21248216
ER

PT J
AU Shackman, AJ
   Maxwell, JS
   McMenamin, BW
   Greischar, LL
   Davidson, RJ
AF Shackman, Alexander J.
   Maxwell, Jeffrey S.
   McMenamin, Brenton W.
   Greischar, Lawrence L.
   Davidson, Richard J.
TI Stress Potentiates Early and Attenuates Late Stages of Visual Processing
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID EVENT-RELATED POTENTIALS; WORKING-MEMORY TASK; HUMAN AMYGDALA; EMOTION;
   ANXIETY; ATTENTION; THREAT; CORTEX; MODULATION; SYSTEM
AB Stress can fundamentally alter neural responses to incoming information. Recent research suggests that stress and anxiety shift the balance of attention away from a task-directed mode, governed by prefrontal cortex, to a sensory-vigilance mode, governed by the amygdala and other threat-sensitive regions. A key untested prediction of this framework is that stress exerts dissociable effects on different stages of information processing. This study exploited the temporal resolution afforded by event-related potentials to disentangle the impact of stress on vigilance, indexed by early perceptual activity, from its impact on task-directed cognition, indexed by later postperceptual activity in humans. Results indicated that threat of shock amplified stress, measured using retrospective ratings and concurrent facial electromyography. Stress also double-dissociated early sensory-specific processing from later task-directed processing of emotionally neutral stimuli: stress amplified N1 (184-236 ms) and attenuated P3 (316-488 ms) activity. This demonstrates that stress can have strikingly different consequences at different processing stages. Consistent with recent suggestions, stress amplified earlier extrastriate activity in a manner consistent with vigilance for threat (N1), but disrupted later activity associated with the evaluation of task-relevant information (P3). These results provide a novel basis for understanding how stress can modulate information processing in everyday life and stress-sensitive disorders.
C1 [Shackman, Alexander J.; Greischar, Lawrence L.; Davidson, Richard J.] Univ Wisconsin, Dept Pathol, Madison, WI 53706 USA.
   [Greischar, Lawrence L.; Davidson, Richard J.] Univ Wisconsin, Lab Affect Neurosci, Madison, WI 53706 USA.
   [Shackman, Alexander J.; Davidson, Richard J.] Univ Wisconsin, Dept Psychiat, Wisconsin Psychiat Inst & Clin, Madison, WI 53719 USA.
   [Davidson, Richard J.] Univ Wisconsin, HealthEmot Res Inst, Madison, WI 53719 USA.
   [Davidson, Richard J.] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI 53705 USA.
   [Davidson, Richard J.] Univ Wisconsin, Ctr Investigating Healthy Minds, Madison, WI 53705 USA.
   [Maxwell, Jeffrey S.] USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
   [McMenamin, Brenton W.] Univ Minnesota Twin Cities, Dept Psychol, Minneapolis, MN 55455 USA.
   [McMenamin, Brenton W.] Univ Minnesota Twin Cities, Ctr Cognit Sci, Minneapolis, MN 55455 USA.
RP Shackman, AJ (reprint author), Univ Wisconsin, Dept Pathol, 1202 W Johnson St, Madison, WI 53706 USA.
EM shackman@wisc.edu; jeffsmaxwell@gmail.com; rjdavids@wisc.edu
FU Department of Defense, Army Research Laboratory Director's Strategic
   Initiative; National Institutes of Health [F31-MH070110, P50-MH52354,
   R37-MH43454, T32-HD007151, T32-MH18931]; National Science Foundation
FX This work was supported by the Department of Defense (National Defense
   Science and Engineering Graduate Fellowship to J.S.M.; Army Research
   Laboratory Director's Strategic Initiative to J.S.M.), National
   Institutes of Health (F31-MH070110 to J.S.M.; P50-MH52354 and
   R37-MH43454 to R.J.D.; and support of B. W. M. and A.J.S. through
   T32-HD007151 and T32-MH18931), and National Science Foundation (Graduate
   Research Fellowship to A.J.S.). We thank K. Berling, S. Blume, D. Cole,
   I. Dolski, L. Friedman, J. Koger, J. Nichols, and A. Teche for
   assistance; and A. Fox, A. Heller, J. Oler, J. E. Shackman, H. Slagter,
   and two anonymous reviewers for critical feedback.
NR 52
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U1 5
U2 26
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD JAN 19
PY 2011
VL 31
IS 3
BP 1156
EP 1161
DI 10.1523/JNEUROSCI.3384-10.2011
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA 708OS
UT WOS:000286373700040
PM 21248140
ER

PT J
AU Rubins, KH
   Hensley, LE
   Relman, DA
   Brown, PO
AF Rubins, Kathleen H.
   Hensley, Lisa E.
   Relman, David A.
   Brown, Patrick O.
TI Stunned Silence: Gene Expression Programs in Human Cells Infected with
   Monkeypox or Vaccinia Virus
SO PLOS ONE
LA English
DT Article
ID DOUBLE-STRANDED-RNA; BROAD SPECIES-SPECIFICITY; DEPENDENT
   PROTEIN-KINASE; HUMAN HELA-CELLS; E3L GENE; OLIGONUCLEOTIDE ARRAYS;
   INTERFERON-ALPHA; BINDING-PROTEINS; ANKARA INFECTION; IMMUNE EVASION
AB Poxviruses use an arsenal of molecular weapons to evade detection and disarm host immune responses. We used DNA microarrays to investigate the gene expression responses to infection by monkeypox virus (MPV), an emerging human pathogen, and Vaccinia virus (VAC), a widely used model and vaccine organism, in primary human macrophages, primary human fibroblasts and HeLa cells. Even as the overwhelmingly infected cells approached their demise, with extensive cytopathic changes, their gene expression programs appeared almost oblivious to poxvirus infection. Although killed (gamma-irradiated) MPV potently induced a transcriptional program characteristic of the interferon response, no such response was observed during infection with either live MPV or VAC. Moreover, while the gene expression response of infected cells to stimulation with ionomycin plus phorbol 12-myristate 13-acetate (PMA), or poly (I-C) was largely unimpaired by infection with MPV, a cluster of pro-inflammatory genes were a notable exception. Poly(I-C) induction of genes involved in alerting the innate immune system to the infectious threat, including TNF-alpha, IL-1 alpha and beta, CCL5 and IL-6, were suppressed by infection with live MPV. Thus, MPV selectively inhibits expression of genes with critical roles in cell-signaling pathways that activate innate immune responses, as part of its strategy for stealthy infection.
C1 [Rubins, Kathleen H.; Relman, David A.] Stanford Univ, Sch Med, Dept Microbiol, Stanford, CA 94305 USA.
   [Rubins, Kathleen H.; Relman, David A.] Stanford Univ, Sch Med, Dept Immunol, Stanford, CA 94305 USA.
   [Rubins, Kathleen H.; Brown, Patrick O.] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA.
   [Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Frederick, MD USA.
   [Relman, David A.] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.
   [Relman, David A.] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA.
   [Brown, Patrick O.] Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA.
RP Rubins, KH (reprint author), Stanford Univ, Sch Med, Dept Microbiol, Stanford, CA 94305 USA.
EM pbrown@stanford.edu
FU Howard Hughes Medical Institute; National Institutes of Health [CA77097,
   AI54922]; Thomas C. and Joan M. Merigan Endowment at Stanford University
FX This investigation was supported by the Howard Hughes Medical Institute
   (POB), National Institutes of Health Grants CA77097 (POB) and AI54922
   (DAR); and the Thomas C. and Joan M. Merigan Endowment at Stanford
   University (DAR). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 18
PY 2011
VL 6
IS 1
AR e15615
DI 10.1371/journal.pone.0015615
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 710NW
UT WOS:000286519500024
PM 21267444
ER

PT J
AU Gust, KA
   Wilbanks, MS
   Guan, X
   Pirooznia, M
   Habib, T
   Yoo, L
   Wintz, H
   Vulpe, CD
   Perkins, EJ
AF Gust, Kurt A.
   Wilbanks, Mitchell S.
   Guan, Xin
   Pirooznia, Mehdi
   Habib, Tanwir
   Yoo, Leslie
   Wintz, Henri
   Vulpe, Chris D.
   Perkins, Edward J.
TI Investigations of transcript expression in fathead minnow (Pimephales
   promelas) brain tissue reveal toxicological impacts of RDX exposure
SO AQUATIC TOXICOLOGY
LA English
DT Article
DE Genomics; Microarray analysis; Pimephales promelas; Fathead minnow;
   Explosives
ID BOBWHITE COLINUS-VIRGINIANUS; UBIQUITIN-DEPENDENT DEGRADATION;
   ELONGATION-FACTOR EF-1-ALPHA; NORTHERN BOBWHITE; GENE-EXPRESSION;
   HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; ISOCITRATE DEHYDROGENASE;
   OXIDATIVE STRESS; NERVOUS-SYSTEM; PROTEIN
AB Production, usage and disposal of the munitions constituent (MC) cyclotrimethylenetrinitramine (RDX) has led to environmental releases on military facilities. The chemical attributes of RDX are conducive for leaching to surface water which may put aquatic organisms at risk of exposure. Because RDX has been observed to cause aberrant neuromuscular effects across a wide range of animal phyla, we assessed the effects of RDX on central nervous system (CNS) functions in the representative aquatic ecotoxicological model species, fathead minnow (Pimephales promelas). We developed a fathead minnow brain-tissue cDNA library enriched for transcripts differentially expressed in response to RDX and trinitrotoluene (TNT) exposure. All 4,128 cDNAs were sequenced, quality filtered and assembled yielding 2230 unique sequences and 945 significant blastx matches (E <= 10(-5)). The cDNA library was leveraged to create custom-spotted microarrays for use in transcript expression assays. The impact of RDX on transcript expression in brain tissue was examined in fathead minnows exposed to RDX at 0.625, 2.5, 5, 10 mg/L or an acetone-spike control for 10 days. Overt toxicity of RDX in fathead minnow occurred only at the highest exposure concentration resulting in 50% mortality and weight loss. Conversely, Bayesian analysis of microarray data indicated significant changes in transcript expression at concentrations as low as 0.625 mg/L. In total, 154 cDNAs representing 44 unique transcripts were differentially expressed in RDX exposures, the majority of which were validated by reverse transcriptase-quantitative PCR (RT-qPCR). Investigation of molecular pathways, gene ontology (GO) and individual gene functions affected by RDX exposures indicated changes in metabolic processes involved in: oxygen transport, neurological function, calcium binding/signaling, energy metabolism, cell growth/division, oxidative stress and ubiquitination. In total, our study indicated that RDX exposure affected molecular processes critical to CNS function in fathead minnow. Published by Elsevier B.V.
C1 [Gust, Kurt A.; Wilbanks, Mitchell S.; Perkins, Edward J.] USA, Corps Engineers, Environm Lab EP P, Vicksburg, MS 39180 USA.
   [Guan, Xin; Habib, Tanwir] SpecPro Inc, ERDC USACE EL EP P, Vicksburg, MS 39180 USA.
   [Pirooznia, Mehdi] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA.
   [Yoo, Leslie; Vulpe, Chris D.] Perennial Environm Serv LLC, Houston, TX 77092 USA.
   [Wintz, Henri] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA.
RP Gust, KA (reprint author), USA, Corps Engineers, Environm Lab EP P, Vicksburg, MS 39180 USA.
EM kurt.a.gust@erdc.usace.army.mil
OI Pirooznia, Mehdi/0000-0002-4210-6458
FU US Army Environmental Quality Technology
FX We thank the anonymous peer reviewers for their comments which greatly
   improved the final version of this paper. This work was supported by the
   US Army Environmental Quality Technology Research Program. Permission
   was granted by the Chief of Engineers to publish this information.
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U1 1
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-445X
EI 1879-1514
J9 AQUAT TOXICOL
JI Aquat. Toxicol.
PD JAN 17
PY 2011
VL 101
IS 1
BP 135
EP 145
DI 10.1016/j.aquatox.2010.09.011
PG 11
WC Marine & Freshwater Biology; Toxicology
SC Marine & Freshwater Biology; Toxicology
GA 715BR
UT WOS:000286855900015
PM 20965580
ER

PT J
AU Rinaldi, RG
   Hsieh, AJ
   Boyce, MC
AF Rinaldi, R. G.
   Hsieh, A. J.
   Boyce, M. C.
TI Tunable Microstructures and Mechanical Deformation in Transparent
   Poly(urethane urea)s
SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS
LA English
DT Article
DE blast application; intermolecular interaction; permeation; phase mixing;
   strain-rate dependency; transparent poly(urethane urea)s
ID STRESS-STRAIN BEHAVIOR; STRUCTURE-PROPERTY RELATIONSHIPS;
   X-RAY-SCATTERING; MICROPHASE-SEPARATED STRUCTURE; THERMOPLASTIC
   POLYURETHANES; SEGMENTED POLYURETHANES; CONFORMATIONAL ISOMERS;
   MOLECULAR-WEIGHT; ELASTOMERS; MORPHOLOGY
AB Transparent poly(urethane urea) (TPUU) materials offer an avenue to enable material designs with potential to achieve simultaneous enhancements in both physical and mechanical properties. To optimize the performance required for each application, the molecular features that influence the microstructure, the glass transition temperature (T(g)), the deformation mechanisms, and the mechanical deformation behavior must be understood and exploited. In this work, a comprehensive materials characterization of select model PUUs with tunable microstructures is addressed. Increasing the hard segment (HS) content increases the stiffness and flow stress levels, whereas altering the soft segment (SS) molecular weight from 2000 to 1000 g/mol leads to an enhanced phase mixing with a SS T(g) shifted similar to 17 degrees K toward higher temperatures as well as broadening of the SS relaxation closer to room temperature. As a result, the 1K TPUU materials display greater rate-dependent stiffening and strain hardening on mechanical deformation over the broad range of strain rates covered in this work (10(-3) to 10(4) s(-1)). In such case of similar urea-based HS content, the molar content of the urethane linkages, per stoichiometric requirements, is much higher in the 1K TPUUs than the 2K TPUUs. These additional urethane moieties lead to an increase in the extent of intermolecular interactions, via hydrogen bonding between the HS and the SS, providing not only further phase mixing and stronger rate sensitivity but also provide 1K TPUUs with drastically improved barrier properties. (C) 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 123-135, 2011
C1 [Rinaldi, R. G.; Boyce, M. C.] MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
   [Hsieh, A. J.] MIT, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA.
   [Hsieh, A. J.] USA, Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
RP Rinaldi, RG (reprint author), MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
EM rrinaldi@engineering.ucsb.edu
FU U.S. Army through Institute for Soldier Nanotechnologies (ISN)
   [W911NF-07-D-0004]; Army; ONR [N00014-04-1-0469, N00014-09-1-0591]
FX This research was supported by the U.S. Army through the Institute for
   Soldier Nanotechnologies (ISN), under Contract W911NF-07-D-0004. A. J.
   Hsieh acknowledges the TPUU materials provided by N. Rice of Triton
   Systems, Inc., through an ISN 6.2 project funded by the Army. A. J.
   Hsieh also thanks F. L. Beyer and J. M. Sloan of Army Research
   Laboratory for providing assistance with SAXS and FTIR-ATR measurements,
   respectively. The authors are grateful to K. C. Krogman of MIT/ISN for
   assistance with permeation measurements. M. C. Boyce and R. Rinaldi also
   acknowledge support from ONR through grants N00014-04-1-0469 and
   N00014-09-1-0591.
NR 38
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U1 4
U2 26
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-6266
J9 J POLYM SCI POL PHYS
JI J. Polym. Sci. Pt. B-Polym. Phys.
PD JAN 15
PY 2011
VL 49
IS 2
BP 123
EP 135
DI 10.1002/polb.22128
PG 13
WC Polymer Science
SC Polymer Science
GA 708ZO
UT WOS:000286403200005
ER

PT J
AU Campanella, A
   La Scala, JJ
   Wool, RP
AF Campanella, Alejandrina
   La Scala, John J.
   Wool, R. P.
TI Fatty Acid-Based Comonomers as Styrene Replacements in Soybean and
   Castor Oil-Based Thermosetting Polymers
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE vegetable oils; fatty acids; lignin; renewable resources; thermosets;
   mechanical properties
ID MAGNETIC-RESONANCE-SPECTROSCOPY; LIQUID MOLDING RESINS; METHYL-ESTERS;
   YIELD DETERMINATION; LIGNIN; EPOXIDATION; MONOMERS; POLYMERIZATION;
   ACRYLATION; KINETICS
AB In this study, a fatty acid-based comonomer is employed as a styrene replacement for the production of triglyceride-based thermosetting resins. Styrene is a hazardous pollutant and a volatile organic compound. Given their low volatility, fatty acid monomers, such as methacrylated lauric acid (MLA), are attractive alternatives in reducing or eliminating styrene usage. Different triglyceride-derived cross-linkers resins were produced for this purpose: acrylated epoxidized soybean oil (AESO), maleinated AESO (MAESO), maleinated soybean oil monoglyceride (SOMG/MA) and maleinated castor oil monoglyceride (COMG/MA). The mechanical properties of the bio-based polymers and the viscosities of bio-based resins were analyzed. The viscosities of the resins using MLA were higher than that of resins with styrene. Decreasing the content of MLA increased the glass transition temperature (T(g)). In fact, the T(g) of bio-based resin/MLA polymers were on the order of 60 degrees C, which was significantly lower than the bio-based resin/styrene polymers. Ternary blends of SOMG/MA and COMG/MA with MLA and styrene improved the mechanical properties and reduced the resin viscosity to acceptable values. Lastly, butyrated kraft lignin was incorporated into the bio-based resins, ultimately leading to improved mechanical properties of this thermoset but with unacceptable increases in viscosity. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 119: 1000-1010, 2011
C1 [Campanella, Alejandrina; Wool, R. P.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA.
   [Campanella, Alejandrina; Wool, R. P.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
   [La Scala, John J.] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MC, Aberdeen Proving Ground, MD 21005 USA.
RP Wool, RP (reprint author), Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA.
EM wool@udel.edu
FU ARL (Army Research Laboratory) through the Army Materials Center of
   Excellence in Composite Materials at the University of Delaware
FX The authors would like to thank ARL (Army Research Laboratory) for
   financial support of this research through the Army Materials Center of
   Excellence in Composite Materials at the University of Delaware. The
   authors also thank M. Zeberkiewicz for helping in the preparation of the
   modified lignin and the Wagner Research Group at the University of
   Delaware, Department of Chemical Engineering for the use of their
   Rheometer.
NR 41
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Z9 30
U1 5
U2 52
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0021-8995
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD JAN 15
PY 2011
VL 119
IS 2
BP 1000
EP 1010
DI 10.1002/app.32810
PG 11
WC Polymer Science
SC Polymer Science
GA 680BQ
UT WOS:000284206900047
ER

PT J
AU Gutteridge, CE
   Hoffman, MM
   Bhattacharjee, AK
   Milhous, WK
   Gerena, L
AF Gutteridge, Clare E.
   Hoffman, Marshall M.
   Bhattacharjee, Apurba K.
   Milhous, Wilbur K.
   Gerena, Lucia
TI In vitro efficacy of 7-benzylamino-1-isoquinolinamines against
   Plasmodium falciparum related to the efficacy of chalcones
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Plasmodium; Malaria; In vitro efficacy; Quinolinamine; Chalcone
ID ANTIMALARIAL ACTIVITY; MALARIA; DERIVATIVES; LICOCHALCONE; ANTAGONISTS;
   AGENTS; DRUGS; MODEL; VIVO
AB A series of 1,7-diaminoisoquinolinamines, that are expected to mediate antimalarial activity by the same mechanism employed by the chalcones, were produced. Six 7-benzylamino-1-isoquinolinamines were found to be submicromolar inhibitors in vitro of drug-resistant Plasmodium falciparum, with the best possessing activity comparable to chloroquine. Despite being developed from a lead that is a DHFR inhibitor, these compounds do not mediate their antimalarial effects by inhibition of DHFR. Published by Elsevier Ltd.
C1 [Gutteridge, Clare E.; Hoffman, Marshall M.] USN Acad, Dept Chem, Annapolis, MD 21402 USA.
   [Bhattacharjee, Apurba K.; Milhous, Wilbur K.; Gerena, Lucia] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Gutteridge, CE (reprint author), USN Acad, Dept Chem, Annapolis, MD 21402 USA.
EM gutterid@usna.edu
FU Military Infectious Diseases Research Program; Office of Naval Research;
   United States Naval Academy; Naval Academy Research Council
FX We are grateful for support of this work by the Military Infectious
   Diseases Research Program; the Office of Naval Research; and the United
   States Naval Academy, including from the Naval Academy Research Council.
   Research was conducted in compliance with the U.S. Animal Welfare Act
   and other federal statutes and regulations relating to animals and
   experiments involving animals and adheres to principles stated in the
   Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996
   edition. Material has been reviewed by the Walter Reed Army Institute of
   Research. There is no objection to its publication. The opinions or
   assertions contained herein are the private views of the authors and are
   not to be construed as official, or reflecting true views of the
   Department of the Army or the Department of Defense.
NR 26
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U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD JAN 15
PY 2011
VL 21
IS 2
BP 786
EP 789
DI 10.1016/j.bmcl.2010.11.099
PG 4
WC Chemistry, Medicinal; Chemistry, Organic
SC Pharmacology & Pharmacy; Chemistry
GA 703RC
UT WOS:000285998000037
PM 21168330
ER

PT J
AU Du, K
   Rood, MJ
   Welton, EJ
   Varma, RM
   Hashmonay, RA
   Kim, BJ
   Kemme, MR
AF Du, Ke
   Rood, Mark J.
   Welton, Ellsworth J.
   Varma, Ravi M.
   Hashmonay, Ram A.
   Kim, Byung J.
   Kemme, Michael R.
TI Optical Remote Sensing To Quantify Fugitive Particulate Mass Emissions
   from Stationary Short-Term and Mobile Continuous Sources: Part I. Method
   and Examples
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DUST; VISIBILITY
AB The emissions of particulate matter (PM) from anthropogenic sources raise public concern. A new method is described here that was developed to complete in situ rapid response measurements of PM mass emissions from fugitive dust sources by use of optical remote sensing (ORS) and an anemometer. The ORS system consists of one ground-based micropulse light detection and ranging (MPL) device that was mounted on a positioner, two open path-Fourier transform infrared (OP-FTIR) spectrometers, and two open path-laser transmissometers (OP-LT). An algorithm was formulated to compute PM light extinction profiles along each of the plume's cross sections that were determined with the MPL Size-specific PM mass emission factors were then calculated by integrating the light extinction profiles with particle mass extinction efficiencies (determined with the OP-FTIRs/OP-LTs) and the wind's speed and direction. This method also quantifies the spatial and temporal variability of the plume's PM mass concentrations across each of the plume's cross sections. Example results from three field studies are also described to demonstrate how this new method is used to determine mass emission factors as well as characterize the dust plumes' horizontal and vertical dimensions
C1 [Du, Ke] Chinese Acad Sci, Inst Urban Environm, Xiamen, Peoples R China.
   [Rood, Mark J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
   [Welton, Ellsworth J.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA.
   [Varma, Ravi M.] Natl Inst Technol Calicut, Dept Phys, Calicut 673601, Kerala, India.
   [Hashmonay, Ram A.] Environ, Chapel Hill, NC 27514 USA.
   [Kim, Byung J.; Kemme, Michael R.] US Army, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61826 USA.
RP Du, K (reprint author), Chinese Acad Sci, Inst Urban Environm, Xiamen, Peoples R China.
EM kdu@iue.ac.cn
RI Du, Ke/A-6649-2012; Welton, Ellsworth/A-8362-2012; Varma,
   Ravi/A-9640-2009
FU Strategic Environmental Research and Development Program [SI-1400];
   Fujian Science and Technology Commission [2010Y0056]; Xiamen
   Distinguished Young Scholar Award [3502Z20105008]; NSFC [41005081]
FX The authors thank the supporting staff from Yuma Proving Ground and
   Yakima Training Center for coordinating the field campaigns, and the
   following agencies that provided funds/support for this research:
   Strategic Environmental Research and Development Program (Project
   SI-1400), Fujian Science and Technology Commission (No. 2010Y0056),
   Xiamen Distinguished Young Scholar Award (No. 3502Z20105008), and the
   NSFC (No. 41005081).
NR 19
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U1 1
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 15
PY 2011
VL 45
IS 2
BP 658
EP 665
DI 10.1021/es101904q
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 704YB
UT WOS:000286090500050
PM 21142142
ER

PT J
AU Du, K
   Yuen, W
   Wang, W
   Rood, MJ
   Varma, RM
   Hashmonay, RA
   Kim, BJ
   Kemme, MR
AF Du, Ke
   Yuen, Wangki
   Wang, Wei
   Rood, Mark J.
   Varma, Ravi M.
   Hashmonay, Ram A.
   Kim, Byung J.
   Kemme, Michael R.
TI Optical Remote Sensing to Quantify Fugitive Particulate Mass Emissions
   from Stationary Short-Term and Mobile Continuous Sources: Part II. Field
   Applications
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID DUST; VISIBILITY
AB Quantification of emissions of fugitive particulate matter (PM) into the atmosphere from military training operations is of interest by the United States Department of Defense. A new range-resolved optical remote sensing (ORS) method was developed to quantify fugitive PM emissions from puff sources (i.e., artillery back blasts), ground-level mobile sources (i.e., movement of tracked vehicles), and elevated mobile sources (i.e., airborne helicopters) in desert areas that are prone to generating fugitive dust plumes. Real-time, in situ mass concentration profiles for PM mass with particle diameters <10 mu m (PM(10)) and <2.5 mu m (PM(2.5)) were obtained across the dust plumes that were generated by these activities with this new method. Back blasts caused during artillery firing were characterized as a stationary short-term puff source whose plumes typically dispersed to <10 m above the ground with durations of 10-30 s. Fugitive PM emissions caused by artillery back blasts were related to the zone charge and ranged from 51 to 463 g PM/firing for PM(10) and 9 to 176 g PM/firing for PM(2.5). Movement of tracked vehicles and flying helicopters was characterized as mobile continuous sources whose plumes typically dispersed 30-50 m above the ground with durations of 100-200 s. Fugitive PM emissions caused by moving tracked vehicles ranged from 8.3 to 72.5 kg PM/km for PM(10) and 1.1 to 17.2 kg PM/km for PM(2.5), and there was no obvious correlation between PM emission and vehicle speed. The emission factor for the helicopter flying at 3 m above the ground ranged from 14.5 to 114.1 kg PM/km for PK(10) and 5.0 to 39.5 kg PM/km for PM(2.5), depending on the velocity of the helicopter and type of soil it flies over. Fugitive PM emissions by an airborne helicopter were correlated with helicopter speed for a particular soil type. The results from this range-resolved ORS method were also compared with the data obtained with another path-integrated ORS method and a Flux Tower method.
C1 [Du, Ke] Chinese Acad Sci, Inst Urban Environm, Xiamen, Peoples R China.
   [Yuen, Wangki; Wang, Wei; Rood, Mark J.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61820 USA.
   [Varma, Ravi M.] Natl Inst Technol, Dept Phys, Calicut 673601, Kerala, India.
   [Hashmonay, Ram A.] ENVIRON, Chapel Hill, NC 27514 USA.
   [Kim, Byung J.; Kemme, Michael R.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Du, K (reprint author), Chinese Acad Sci, Inst Urban Environm, Xiamen, Peoples R China.
EM kdu@iue.ac.cn
RI Varma, Ravi/A-9640-2009; Du, Ke/A-6649-2012
OI Yuen, Wangki/0000-0001-7612-7524; 
FU Strategic Environmental Research and Development Program [SI-1400];
   Fujian Science and Technology Commission [2010Y0056]; Xiamen
   Distinguished Young Scholar Award [3502Z20105008]; NSFC [41005081]
FX The authors thank the supporting staff from Yuma Proving Ground and
   Yakima Training Center for coordinating the field campaigns, and the
   following agencies that provided funds/support for this research:
   Strategic Environmental Research and Development Program (Project
   SI-1400); Fujian Science and Technology Commission (No. 2010Y0056),
   Xiamen Distinguished Young Scholar Award (No. 3502Z20105008), and the
   NSFC (No. 41005081).
NR 17
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U1 1
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD JAN 15
PY 2011
VL 45
IS 2
BP 666
EP 672
DI 10.1021/es101906v
PG 7
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 704YB
UT WOS:000286090500051
PM 21142143
ER

PT J
AU Wamkam, CT
   Opoku, MK
   Hong, HP
   Smith, P
AF Wamkam, Carine Tchamakam
   Opoku, Michael Kwabena
   Hong, Haiping
   Smith, Pauline
TI Effects of pH on heat transfer nanofluids containing ZrO2 and TiO2
   nanoparticles
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID THERMAL-CONDUCTIVITY ENHANCEMENT; CARBON NANOTUBE; SUSPENSIONS
AB In this paper, pH influences of zeta potential, particle size distribution, rheology, viscosity, and stability on heat transfer nanofluids are studied. Significant enhancement of thermal conductivity (TC) (>20%) containing 3 wt % zirconium dioxide (ZrO2) and titanium dioxide (TiO2) are observed near the isoelectric point (IEP). Meanwhile, at this IEP (pH), particle sizes, and viscosities of these nanofluids demonstrate a significant increase to maximum values. Experimental results also indicate that the stabilities of these nanofluids are influenced by pH values. The reasonable explanation for these interesting phenomena is that at this IEP, the repulsive forces among metal oxides are zero and nanoparticles coagulate together at this pH value. According to the Derjaguin-Landau- Verwey-Overbeek theory, when the pH is equal to or close to the IEP, nanoparticles tend to be unstable, form clusters, and precipitate. The resulting big clusters will trap water and the structures of trapped water are varied due to the strong atomic force among nanoparticles. Water is packed well inside and volume fraction of the nanoparticles will be larger. In addition, shapes of clusters containing trapped water will not be spherical but rather has irregular structure (like chains). Such structure favors thermal transport because they provide a long link. Therefore, overall TC of nanofluids is enhanced. Some literature results and conclusions related to pH effects of nanofluids are discussed and analyzed. Understanding pH effects may enable exploration of fundamental nature of nanofluids. (C) 2011 American Institute of Physics. [doi:10.1063/1.3532003]
C1 [Wamkam, Carine Tchamakam; Opoku, Michael Kwabena; Hong, Haiping] S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA.
   [Smith, Pauline] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Wamkam, CT (reprint author), S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA.
EM haiping.hong@sdsmt.edu
FU Army Research Laboratory [W911NF-08-2-0022]; NASA EPSCoR [NNX09AU83A]
FX The financial support of Army Research Laboratory (Cooperative Agreement
   No. W911NF-08-2-0022) and NASA EPSCoR (Award No. NNX09AU83A) are
   acknowledged.
NR 23
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PU AMER INST PHYSICS
PI MELVILLE
PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1,
   MELVILLE, NY 11747-4501 USA
SN 0021-8979
J9 J APPL PHYS
JI J. Appl. Phys.
PD JAN 15
PY 2011
VL 109
IS 2
AR 024305
DI 10.1063/1.3532003
PG 5
WC Physics, Applied
SC Physics
GA 715PM
UT WOS:000286896400085
ER

PT J
AU Butkus, MA
   Johnson, MC
AF Butkus, Michael A.
   Johnson, Marie C.
TI Influence of phosphate on the transport properties of lead in sand
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Lead; Breakthrough curve; Temporal moment analysis; DLVO; Phosphate
ID SATURATED POROUS-MEDIA; SHOOTING-RANGE SOILS; EXPERIMENTAL-VERIFICATION;
   COLLOIDAL PARTICLES; CONTAMINATED SOILS; SOLUTE TRANSPORT; SURFACE; PB;
   NANOMATERIALS; SPECTROSCOPY
AB Temporal moment analysis was used to examine the transport of lead species in sand columns. The influence of sodium phosphate (PO(4(aq))) and hydroxyapatite (HA) on lead transport was also evaluated. Transport properties of lead microparticles (diameter > 0.45 mu m) were a function of electrophoretic mobility: those particles with electrophoretic mobility less than -1 x 10(-8) m(2)/V s exhibited significantly lower dimensionless first temporal moment (theta) and second temporal moment (sigma(2)(theta)). The forms of lead investigated in this work had a tendency to move in sand over a wide pH range. Although the PO(4(aq)) amendment substantially reduced lead mass recoveries in the sand column effluent, lead microparticles were formed that had a tendency to move rapidly and with minimal dispersion when compared with controls. Treatments with HA provided limited reduction in lead mass recovery and minimal changes in lead transport properties. A colloid stability model was used to predict attachment of lead particles in sand. Published by Elsevier B.V.
C1 [Butkus, Michael A.; Johnson, Marie C.] US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA.
RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA.
EM Michael.Butkus@usma.edu
FU US Army Corps of Engineers Engineer Research Development Center (ERDC)
FX The technical assistance of Mr. Anand Shetty, Major Phil Dacunto,
   Colonel Jason Lynch and Major James Jordano, Department of Geography and
   Environmental Engineering, United States Military Academy is greatly
   appreciated. This project was supported by grants from the US Army Corps
   of Engineers Engineer Research Development Center (ERDC). Although the
   research presented in this paper has been undertaken by personnel
   employed by US Military Academy, it does not necessarily reflect the
   views of the Academy or the US Army.
NR 49
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U1 1
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD JAN 15
PY 2011
VL 185
IS 1
BP 275
EP 280
DI 10.1016/j.jhazmat.2010.09.030
PG 6
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 749EP
UT WOS:000289446700039
PM 20934809
ER

PT J
AU Qiu, HW
   Stepanov, V
   Di Stasio, AR
   Chou, TM
   Lee, WY
AF Qiu, Hongwei
   Stepanov, Victor
   Di Stasio, Anthony R.
   Chou, Tsengming
   Lee, Woo Y.
TI RDX-based nanocomposite microparticles for significantly reduced shock
   sensitivity
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE RDX; Nanocomposite microparticles; Spray drying; Explosives; Insensitive
   munitions
ID ENERGETIC MATERIALS; DRUG-DELIVERY; IMPACT; PARTICLES; NANOPARTICLES;
   EXPLOSIVES; INITIATION; IGNITION
AB Cyclotrimethylenetrinitramine (RDX)-based nanocomposite microparticles were produced by a simple, yet novel spray drying method. The microparticles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and high performance liquid chromatography (HPLC), which shows that they consist of small RDX crystals (similar to 0.1-1 mu m) uniformly and discretely dispersed in a binder. The microparticles were subsequently pressed to produce dense energetic materials which exhibited a markedly lower shock sensitivity. The low sensitivity was attributed to small crystal size as well as small void size (similar to 250 nm). The method developed in this work may be suitable for the preparation of a wide range of insensitive explosive compositions. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Qiu, Hongwei; Chou, Tsengming; Lee, Woo Y.] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA.
   [Stepanov, Victor; Di Stasio, Anthony R.] USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
RP Qiu, HW (reprint author), Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ 07030 USA.
EM hqiu@stevens.edu
RI Qiu, Hongwei/F-5635-2012
FU U.S. Army, ARDEC [W15QKN-05-D-0011]
FX The authors thank the U.S. Army, ARDEC for funding this project under
   the contract of W15QKN-05-D-0011. We also thank Ted Dolch and Gerard
   Gillen for assistance with shock sensitivity testing.
NR 30
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3894
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD JAN 15
PY 2011
VL 185
IS 1
BP 489
EP 493
DI 10.1016/j.jhazmat.2010.09.058
PG 5
WC Engineering, Environmental; Engineering, Civil; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA 749EP
UT WOS:000289446700066
PM 20940087
ER

PT J
AU Michelow, IC
   Lear, C
   Scully, C
   Prugar, LI
   Longley, CB
   Yantosca, LM
   Ji, X
   Karpel, M
   Brudner, M
   Takahashi, K
   Spear, GT
   Ezekowitz, RAB
   Schmidt, EV
   Olinger, GG
AF Michelow, Ian C.
   Lear, Celli
   Scully, Corinne
   Prugar, Laura I.
   Longley, Clifford B.
   Yantosca, L. Michael
   Ji, Xin
   Karpel, Marshall
   Brudner, Matthew
   Takahashi, Kazue
   Spear, Gregory T.
   Ezekowitz, R. Alan B.
   Schmidt, Emmett V.
   Olinger, Gene G.
TI High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
ID PHASE-I SAFETY; STAPHYLOCOCCUS-AUREUS
AB Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although recombinant human MBL (rhMBL) trials have focused on reconstitution therapy, safety studies have identified no barriers to its use at higher levels. Ebola viruses cause fatal hemorrhagic fevers for which no treatment exists and that are feared as potential biothreat agents. We found that mice whose rhMBL serum concentrations were increased >= 7-fold above average human levels survived otherwise. fatal Ebola virus infections and became immune to virus rechallenge. Because Ebola glycoproteins potentially model other glycosylated viruses, rhMBL may offer a novel broad-spectrum antiviral approach.
C1 [Schmidt, Emmett V.] Massachusetts Gen Hosp, Canc Res Ctr, Boston, MA 02114 USA.
   [Michelow, Ian C.; Yantosca, L. Michael; Karpel, Marshall; Brudner, Matthew; Takahashi, Kazue; Ezekowitz, R. Alan B.] Harvard Univ, Sch Med, Dept Pediat, Massachusetts Gen Hosp,Programs Dev Immunol, Boston, MA 02115 USA.
   [Lear, Celli; Scully, Corinne; Prugar, Laura I.; Olinger, Gene G.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA.
   [Longley, Clifford B.] Enzon Pharmaceut, Bridgewater, NJ USA.
   [Ji, Xin; Spear, Gregory T.] Rush Univ, Med Ctr, Dept Immunol & Microbiol, Chicago, IL 60612 USA.
RP Schmidt, EV (reprint author), Massachusetts Gen Hosp, Canc Res Ctr, Boston, MA 02114 USA.
EM eschmidt@partners.org
OI Olinger, Gene/0000-0001-7338-0292
FU National Institutes of Health (NIH) [U01-AI070330, ROI CA112021, 1UO1
   AI074503, 1R21 AI077081]; Defense Threat Reduction Agency Medical
   Biological Defense Research [4.10007_08_RD_B]
FX This study was supported by grant U01-AI070330 to E.V.S. from the
   National Institutes of Health (NIH). E.V.S. was additionally supported
   by NIH grant ROI CA112021. G.G.O. was additionally supported by the
   Defense Threat Reduction Agency Medical Biological Defense Research
   Program, Therapeutic Research Program 4.10007_08_RD_B. K.T. received
   additional support from NIH grants 1UO1 AI074503 and 1R21 AI077081.
NR 15
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U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-1899
J9 J INFECT DIS
JI J. Infect. Dis.
PD JAN 15
PY 2011
VL 203
IS 2
BP 175
EP 179
DI 10.1093/infdis/jiq025
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA 705XB
UT WOS:000286172900007
PM 21288816
ER

PT J
AU Stanzione, JF
   Strawhecker, KE
   Wool, RP
AF Stanzione, J. F., III
   Strawhecker, K. E.
   Wool, R. P.
TI Observing the twinkling fractal nature of the glass transition
SO JOURNAL OF NON-CRYSTALLINE SOLIDS
LA English
DT Article
DE Glass transition; Dynamic fractal networks; Percolation; Solid-state
   structure; Atomic force microscopy
ID FORMING LIQUIDS; AMORPHOUS SOLIDS; TEMPERATURE; FLUCTUATIONS;
   RELAXATION; DEPENDENCE; NETWORKS
AB A fundamental understanding of the nature and structure of the glass transition in amorphous materials is currently seen as a major unsolved problem in solid-state physics. A new conceptual approach to understanding the glass transition temperature (T-g) of glass-forming liquids called the twinkling fractal theory (TFT) has been proposed in order to solve this problem. The main idea underlying the TFT is the development of dynamic rigid percolating solid fractal structures near T-g, which are said to be in dynamic equilibrium with the surrounding liquid. This idea is coupled with the concept of the Boltzmann population of excited vibrational states in the anharmonic intermolecular potential between atoms in the energy landscape. Solid and liquid clusters interchange or "twinkle" at a cluster size dependent frequency omega(TF), which is controlled by the population of intermolecular oscillators in excited energy levels. The solid-to-liquid cluster transitions are in accord with the Orbach vibrational density of states for a particular fractal cluster g(omega)similar to omega(df) (-) (1) where the fracton dimension d(f)=4/3. To an observer, these clusters would appear to be "twinkling." In this paper, experimental evidence supporting the TFT is presented. The twinkling fractal characteristics of amorphous, atactic polystyrene have been captured via atomic force microscopy (AFM). Successive two-dimensional height AFM images reveal that the percolated solid fractal clusters exist for longer time scales at lower temperatures and have lifetimes that are cluster size dependent. The computed fractal dimensions, approximate to 1.88, are shown to be in excellent agreement with the theory of the fractal nature of percolating clusters in accord with the TFT. The twinkling dynamics of polystyrene within its glass transition region are captured with time-lapse one-dimensional AFM phase images. The autocorrelation cluster relaxation function was found to behave as C(t) - t(-4/3) and the cluster lifetimes tau versus width R were found to be in excellent agreement with the TFT via tau similar to R-1.42. This paper provides compelling new experimental evidence for the twinkling fractal nature of the glass transition. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Stanzione, J. F., III; Wool, R. P.] Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA.
   [Stanzione, J. F., III; Wool, R. P.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA.
   [Strawhecker, K. E.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Wool, RP (reprint author), Univ Delaware, Dept Chem Engn, Newark, DE 19716 USA.
EM wool@udel.edu
FU U.S. Army Research Laboratory [W911NF-06-2-011]
FX The authors are grateful to the U.S. Army Research Laboratory for
   financial support under the Army Materials Center of Excellence Program,
   contract W911NF-06-2-011. The author J.F. Stanzione III is also grateful
   for generous mentorship of Dr. Kenneth Strawhecker and Dr. David Webb
   from the ARL-APG.
NR 36
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U1 4
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-3093
EI 1873-4812
J9 J NON-CRYST SOLIDS
JI J. Non-Cryst. Solids
PD JAN 15
PY 2011
VL 357
IS 2
SI SI
BP 311
EP 319
DI 10.1016/j.jnoncrysol.2010.06.041
PG 9
WC Materials Science, Ceramics; Materials Science, Multidisciplinary
SC Materials Science
GA 725JK
UT WOS:000287640800014
ER

PT J
AU Murphey, YL
   Chen, ZH
   Kiliaris, L
   Masrur, MA
AF Murphey, Yi L.
   Chen, ZhiHang
   Kiliaris, Leonidas
   Masrur, M. Abul
TI Intelligent power management in a vehicular system with multiple power
   sources
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Electric power management; Vehicular power system; Energy management;
   Power demand duty cycle
ID PARALLEL HYBRID VEHICLE; OPTIMIZATION; STRATEGIES; DESIGN; AGENT
AB This paper presents an optimal online power management strategy applied to a vehicular power system that contains multiple power sources and deals with largely fluctuated load requests. The optimal online power management strategy is developed using machine learning and fuzzy logic. A machine learning algorithm has been developed to learn the knowledge about minimizing power loss in a Multiple Power Sources and Loads (M_PS&LD) system. The algorithm exploits the fact that different power sources used to deliver a load request have different power losses under different vehicle states. The machine learning algorithm is developed to train an intelligent power controller, an online fuzzy power controller, FPC_MPS, that has the capability of finding combinations of power sources that minimize power losses while satisfying a given set of system and component constraints during a drive cycle. The FPC_MPS was implemented in two simulated systems, a power system of four power sources, and a vehicle system of three power sources. Experimental results show that the proposed machine learning approach combined with fuzzy control is a promising technology for intelligent vehicle power management in a M_PS&LD power system. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Murphey, Yi L.; Chen, ZhiHang; Kiliaris, Leonidas] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA.
   [Masrur, M. Abul] USA, RDECOM TARDE, Warren, MI USA.
RP Chen, ZH (reprint author), Univ Michigan, Dept Elect & Comp Engn, 4901 Evergreen Rd, Dearborn, MI 48128 USA.
EM zhchen@umich.edu
FU U.S. Army RDECOM-TARDEC [DAAEO7-03-C-L098]
FX This work was supported in part by the U.S. Army RDECOM-TARDEC under the
   contract DAAEO7-03-C-L098.
NR 32
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U1 3
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
J9 J POWER SOURCES
JI J. Power Sources
PD JAN 15
PY 2011
VL 196
IS 2
SI SI
BP 835
EP 846
DI 10.1016/j.jpowsour.2010.07.052
PG 12
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
   Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA 663ZU
UT WOS:000282929500034
ER

PT J
AU Shiraki, H
   Kozar, MP
   Melendez, V
   Hudson, TH
   Ohrt, C
   Magill, AJ
   Lin, AJ
AF Shiraki, Hiroaki
   Kozar, Michael P.
   Melendez, Victor
   Hudson, Thomas H.
   Ohrt, Colin
   Magill, Alan J.
   Lin, Ai J.
TI Antimalarial Activity of Novel 5-Aryl-8-Aminoquinoline Derivatives
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID INDUCED HEMOLYTIC-ANEMIA; TROPHOZOITE-INDUCED INFECTIONS;
   IMIDAZOLIDINEDIONE DERIVATIVES; PLASMODIUM-FALCIPARUM; PRIMAQUINE;
   DRUGS; ERYTHROCYTE; MALARIA; INVITRO; 6-METHOXY-8-HYDROXYLAMINOQUINOLINE
AB In an attempt to separate the antimalarial activity of tafenoquine (3) from its hemolytic side effects in glucose-6-phosphate dehydrogenase (G6PD) deficiency patients, a series of 5-aryl-8-aminoquinoline derivative, was prepared and assessed for antimalarial activities The new compounds were found metabolically stable in human and mouse microsomal preparations, with t(1/2) > 60 mm, and were equal to or more potent than primaquine (2) and 3 against Plasmodium falciparum cell growth The new agents were more active against the chloroquine (CQ) resistant clone than to the CQ-sensitive clone Analogues with electron donating groups showed better activity than those with electron withdrawing substituents Compounds 4bc, 4bd, and 4be showed comparable therapeutic index (TI) to that of 2 and 3, with TI ranging from 5 to 8 based on IC(50) data The new compounds showed no significant causal prophylactic activity in mice infected with Plasmodium berghei sporozoites, but are substantially less toxic than 2 and 3 in mouse tests
C1 [Shiraki, Hiroaki; Kozar, Michael P.; Melendez, Victor; Hudson, Thomas H.; Ohrt, Colin; Magill, Alan J.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RI Kozar, Michael/A-9155-2011; Hudson, Thomas/A-9152-2011
FU Walter Reed Army Institute of Research
FX Material has been reviewed by the Walter Reed Army Institute of Research
   There is no objection to its presentation and/or publications The
   opinions or assertions contained het em are the private views of the
   authors and are not to be constitued as official or as reflecting true
   views of the Department of the Army or the Department of Defense This
   research was performed while Dr Hiroaki Shiraki held a National Research
   Council Research Associateship Award at the Walter Reed Army Institute
   of Research
NR 41
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U1 0
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
J9 J MED CHEM
JI J. Med. Chem.
PD JAN 13
PY 2011
VL 54
IS 1
BP 131
EP 142
DI 10.1021/jm100911f
PG 12
WC Chemistry, Medicinal
SC Pharmacology & Pharmacy
GA 701KY
UT WOS:000285818000010
PM 21141892
ER

PT J
AU Chen, ZY
   Lu, XCM
   Shear, DA
   Dave, JR
   Davis, AR
   Evangelista, CA
   Duffy, D
   Tortella, FC
AF Chen, Zhiyong
   Lu, X. -C. May
   Shear, Deborah A.
   Dave, Jitendra R.
   Davis, Angela R.
   Evangelista, Clifford A.
   Duffy, Danelle
   Tortella, Frank C.
TI Synergism of human amnion-derived multipotent progenitor (AMP) cells and
   a collagen scaffold in promoting brain wound recovery: Pre-clinical
   studies in an experimental model of penetrating ballistic-like brain
   injury
SO BRAIN RESEARCH
LA English
DT Article
DE Human amnion; Progenitor cells; Traumatic brain injury; Penetrating
   ballistic-like brain injury; Axon degeneration; Collagen scaffold
ID TRAUMATIC BRAIN; EPITHELIAL-CELLS; RAT MODEL; NEURAL TRANSPLANTATION;
   FUNCTIONAL RECOVERY; SPINAL-CORD; STEM-CELLS; DIFFERENTIATION;
   IMPLANTATION; DISEASE
AB One of the histopathological consequences of a penetrating ballistic brain injury is the formation of a permanent cavity. In a previous study using the penetrating ballistic-like brain injury (PBBI) model, engrafted human amnion-derived multipotent progenitor (AMP) cells failed to survive when injected directly in the injury tract, suggesting that the cell survival requires a supportive matrix. In this study, we seated AMP cells in a collagen-based scaffold, injected into the injury core, and investigated cell survival and neuroprotection following PBBI. AMP cells suspended in AMP cell conditioned medium (ACCS) or in a liquefied collagen matrix were injected immediately after a PBBI along the penetrating injury tract. Injured control rats received only liquefied collagen matrix. All animals were allowed to survive two weeks. Consistent with our previous results, AMP cells suspended in ACCS failed to survive; likewise, no collagen was identified at the injury site when injected alone. In contrast, both AMP cells and the collagen were preserved in the injury cavity when injected together. In addition, AMP cells/collagen treatment preserved some apparent brain tissue in the injury cavity, and there was measurable infiltration of endogenous neural progenitor cells and astrocytes into the preserved brain tissue. AMP cells were also found to, have migrated into the subventricular zone and the corpus callosum. Moreover, the AMP cell/collagen treatment significantly attenuated the PBBI-induced axonal degeneration in the corpus callosum and ipsilateral thalamus and improved motor impairment on rotarod performance. Overall, collagen-based scaffold provided a supportive matrix for AMP cell survival, migration, and neuroprotection. Published by Elsevier B.V.
C1 [Chen, Zhiyong; Lu, X. -C. May; Shear, Deborah A.; Dave, Jitendra R.; Davis, Angela R.; Evangelista, Clifford A.; Tortella, Frank C.] Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA.
   [Duffy, Danelle] Stemnion Inc, Pittsburgh, PA USA.
RP Chen, ZY (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Zhiyong.chen@amedd.army.mil
RI Shear, Deborah/B-3607-2011; Dave, Jitendra/A-8940-2011
FU DOD [W81XWH-08-2-0127]
FX Funding for this project was provided by DOD CDMRP Grant
   W81XWH-08-2-0127. The material has been reviewed by the Walter Reed Army
   Institute of Research. There is no objection to its presentation and/or
   publication. The opinions or assertions contained herein are the private
   views of the authors, and are not to be construed as official, or as
   reflecting true views of the Department of the Army or Department of
   Defense. The authors have no conflict of interest.
NR 36
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U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
J9 BRAIN RES
JI Brain Res.
PD JAN 12
PY 2011
VL 1368
BP 71
EP 81
DI 10.1016/j.brainres.2010.10.028
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA 714ZJ
UT WOS:000286849900009
PM 20951684
ER

PT J
AU Convertino, M
   Elsner, JB
   Munoz-Carpena, R
   Kiker, GA
   Martinez, CJ
   Fischer, RA
   Linkov, I
AF Convertino, Matteo
   Elsner, James B.
   Munoz-Carpena, Rafael
   Kiker, Gregory A.
   Martinez, Christopher J.
   Fischer, Richard A.
   Linkov, Igor
TI Do Tropical Cyclones Shape Shorebird Habitat Patterns? Biogeoclimatology
   of Snowy Plovers in Florida
SO PLOS ONE
LA English
DT Article
ID GULF-OF-MEXICO; CHARADRIUS-ALEXANDRINUS; BIRD POPULATIONS; NATAL
   DISPERSAL; CLIMATE-CHANGE; HURRICANES; FREQUENCY; AVIFAUNA; ISLANDS;
   IMPACT
AB Background: The Gulf coastal ecosystems in Florida are foci of the highest species richness of imperiled shoreline dependent birds in the USA. However environmental processes that affect their macroecological patterns, like occupancy and abundance, are not well unraveled. In Florida the Snowy Plover (Charadrius alexandrinus nivosus) is resident along northern and western white sandy estuarine/ocean beaches and is considered a state-threatened species.
   Methodology/Principal Findings: Here we show that favorable nesting areas along the Florida Gulf coastline are located in regions impacted relatively more frequently by tropical cyclones. The odds of Snowy Plover nesting in these areas during the spring following a tropical cyclone impact are seven times higher compared to the odds during the spring following a season without a cyclone. The only intensity of a tropical cyclone does not appear to be a significant factor affecting breeding populations.
   Conclusions/Significance: Nevertheless a future climate scenario featuring fewer, but more extreme cyclones could result in a decrease in the breeding Snowy Plover population and its breeding range. This is because the spatio-temporal frequency of cyclone events was found to significantly affect nest abundance. Due to the similar geographic range and habitat suitability, and no decrease in nest abundance of other shorebirds in Florida after the cyclone season, our results suggest a common bioclimatic feedback between shorebird abundance and tropical cyclones in breeding areas which are affected by cyclones.
C1 [Convertino, Matteo; Munoz-Carpena, Rafael; Kiker, Gregory A.; Martinez, Christopher J.] Univ Florida, IFAS, Dept Agr & Biol Engn, Gainesville, FL 32611 USA.
   [Convertino, Matteo; Linkov, Igor] USA, Corps Engineers, Engn Res & Dev Ctr ERDC, Risk & Decis Sci Grp, Concord, MA USA.
   [Elsner, James B.] Florida State Univ, Dept Geog, Tallahassee, FL 32306 USA.
   [Fischer, Richard A.] USA, Corps Engineers, Environm Lab, Engn Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
   [Linkov, Igor] Carnegie Mellon Univ, Dept Engn & Publ Policy, Pittsburgh, PA 15213 USA.
RP Convertino, M (reprint author), Univ Florida, IFAS, Dept Agr & Biol Engn, Gainesville, FL 32611 USA.
EM mconvertino@ufl.edu
RI Munoz-Carpena, Rafael/A-7588-2010
OI Munoz-Carpena, Rafael/0000-0003-2838-1514
FU United States Department of Defense [SI-1699, SI-1700]
FX This research was supported by the United States Department of Defense,
   through the Strategic Environmental Research and Development Program
   (SERDP), Projects SI-1699 and SI-1700. Permission was granted to publish
   this material by the United States Army Corps of Engineers (USACE) Chief
   of Engineers. The views and opinions expressed in this paper are those
   of the individual authors and not those of the United States Army or
   other sponsor organizations. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
NR 53
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U1 1
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 12
PY 2011
VL 6
IS 1
AR e15683
DI 10.1371/journal.pone.0015683
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA 710LX
UT WOS:000286514300002
PM 21264268
ER

PT J
AU Li, QG
   Hickman, M
AF Li, Qigui
   Hickman, Mark
TI Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and
   predict the neurotoxicity of artemisinins
SO TOXICOLOGY
LA English
DT Review
DE Neurotoxicity; Artemisinin derivatives; Dihydroartemisinin; Drug
   exposure level; Drug exposure time; Pharmacokinetic profiles; Animal
   species
ID BRAIN-STEM ENCEPHALOPATHY; FALCIPARUM-MALARIA; MACACA-MULATTA; ARTELINIC
   ACID; BREAST-CANCER; ARTEETHER; RATS; ARTEMETHER; ARTESUNATE;
   DIHYDROARTEMISININ
AB Studies with laboratory animals have demonstrated fatal neurotoxicity that is associated with administration of artemether (AM) and arteether (AE) intramuscularly or artelinic acid (AL) orally. Toxicokinetic studies showed oil-soluble artemisinins form a depot at the intramuscular injection sites, which is associated with fascia inflammation in muscles. Oral administration of AL induces a gastrointestinal toxicity that is linked with delayed gastric emptying. These effects suggest that the exposure time of artemisinins was extended due to drug accumulation in blood, and this in turn resulted in neurotoxicity. In the present report, the drug exposure time with a neurotoxic outcome (neurotoxic exposure time) was evaluated as a predictor of neurotoxicity in vivo. The neurotoxic exposure time represents a total time spent above a lowest observed neurotoxic effect levels (LONEL) in plasma. The dose of AE required to induce minimal neurotoxicity requires a 2-3 fold longer exposure time in rhesus monkeys (179.5 h) than in rats (67.1 h) and dogs (103.7 h) by using a daily dose of 6-12.5 mg/kg for 7-28 days, indicating that the safe dosing duration in monkeys should be longer than 7 days under the exposure. The neurotoxic exposure time of artemisinins could be longer in humans as the comparison of monkeys to humans is likely more relevant than from rodents or dogs. Oral AL required much longer exposure times (8-fold) than intramuscular AE to induce neurotoxicity, suggesting that water-soluble artemisinins appear to be much safer than oil-soluble artemisinins. Due to lower doses (2-4 mg/kg) used with current artemisinins and the more rare use of AE in treating humans the exposure time is much shorter in humans. Therefore, the current regimen of 3-5 days dosing duration should be quite safe. These findings support a recently published WHO guide for malaria treatment with artemisinin regimens, such as artemisinin-based combination therapies and injectable artesunate, to avoid neurotoxicity. Published by Elsevier Ireland Ltd.
C1 [Li, Qigui; Hickman, Mark] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
RP Li, QG (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Pharmacol, 503 Robert Grant Ave, Silver Spring, MD 20307 USA.
EM qigui.li@us.army.mil
FU United States Army Research and Materiel Command
FX This report was supported by the United States Army Research and
   Materiel Command. The opinions or assertions contained herein are the
   private views of the author and are not to be construed as official, or
   as reflecting true views of the Department of the Army or the Department
   of Defense.
NR 49
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U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD JAN 11
PY 2011
VL 279
IS 1-3
BP 1
EP 9
DI 10.1016/j.tox.2010.09.005
PG 9
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 718GU
UT WOS:000287109900001
PM 20863871
ER

PT J
AU Genovese, RF
   Benton, BJ
   Oubre, JL
   Byers, CE
   Jakubowski, EM
   Mioduszewski, RJ
   Settle, TJ
   Steinbach, TJ
AF Genovese, Raymond F.
   Benton, Bernard J.
   Oubre, John L.
   Byers, Christopher E.
   Jakubowski, E. Michael
   Mioduszewski, Robert J.
   Settle, Timothy J.
   Steinbach, Thomas J.
TI Determination of threshold adverse effect doses of percutaneous VX
   exposure in African green monkeys
SO TOXICOLOGY
LA English
DT Article
DE VX; Primate; Percutaneous; African green; SPR; AChE; Organophosphorus;
   Cognition
ID BODY VAPOR EXPOSURE; LOW-LEVEL; CHEMICAL WARFARE; DERMAL TOXICITY;
   DOMESTIC SWINE; NERVE AGENTS; GUINEA-PIGS; SARIN; SOMAN; ABSORPTION
AB Percutaneous exposure to the chemical warfare nerve agent VX was evaluated in African green monkeys (n = 9). Doses of VX (7.5-100 mu g/kg) were applied to the skin for 60 min and residual agent was quantified (before decontamination) to estimate the absorbed dose. Monkeys were evaluated for the presence or absence of clinical signs of toxicity and blood was sampled periodically (30 min-12 weeks) following exposure to measure the degree of circulating acetylcholinesterase (AChE) inhibition. Monkeys were also evaluated for behavioral changes from VX exposure using a serial probe recognition (SPR) task. The lowest observable adverse effect level (LOAEL) for the production of major clinical signs was determined to be 42.22 mu g/kg (absorbed dose estimate = 17.36 mu g/kg) and the LOAEL for AChE inhibition was 13.33 mu g/kg (absorbed dose estimate = 6.53 rig/kg). Behavioral performance was unaffected at doses that, while producing substantial AChE inhibition, did not produce clinical signs. VX represents a substantial threat as a contact hazard and these results complement previous studies using the percutaneous route of exposure with VX and extend the findings to a non-human primate species. Published by Elsevier Ireland Ltd.
C1 [Genovese, Raymond F.; Oubre, John L.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA.
   [Settle, Timothy J.] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD 20910 USA.
   [Steinbach, Thomas J.] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA.
   [Benton, Bernard J.; Mioduszewski, Robert J.] USA, Operat Toxicol Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
   [Byers, Christopher E.; Jakubowski, E. Michael] USA, Analyt Toxicol Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Raymond.Genovese@US.ARMY.MIL
FU Defense Threat Reduction Agency
FX This research was supported by the Defense Threat Reduction Agency.
NR 31
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U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD JAN 11
PY 2011
VL 279
IS 1-3
BP 65
EP 72
DI 10.1016/j.tox.2010.09.012
PG 8
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA 718GU
UT WOS:000287109900008
PM 20887765
ER

PT J
AU Vann, RD
   Butler, FK
   Mitchell, SJ
   Moon, RE
AF Vann, Richard D.
   Butler, Frank K.
   Mitchell, Simon J.
   Moon, Richard E.
TI Decompression illness
SO LANCET
LA English
DT Article
ID PATENT FORAMEN OVALE; ARTERIAL GAS EMBOLISM; TO-LEFT SHUNT;
   HYPERBARIC-OXYGEN THERAPY; INNER-EAR; BUBBLE FORMATION; PULMONARY-EDEMA;
   AIR-EMBOLISM; SCUBA-DIVERS; CEREBRAL PROTECTION
AB Decompression illness is caused by intravascular or extravascular bubbles that are formed as a result of reduction in environmental pressure (decompression). The term covers both arterial gas embolism, in which alveolar gas or venous gas emboli (via cardiac shunts or via pulmonary vessels) are introduced into the arterial circulation, and decompression sickness, which is caused by in-situ bubble formation from dissolved inert gas. Both syndromes can occur in divers, compressed air workers, aviators, and astronauts, but arterial gas embolism also arises from iatrogenic causes unrelated to decompression. Risk of decompression illness is affected by immersion, exercise, and heat or cold. Manifestations range From itching and minor pain to neurological symptoms, cardiac collapse, and death. First-aid treatment is 100% oxygen and definitive treatment is recompression to increased pressure, breathing 100% oxygen. Adjunctive treatment, including fluid administration and prophylaxis against venous thromboembolism in paralysed patients, is also recommended. Treatment is, in most cases, effective although residual deficits can remain in serious cases, even after several recompressions.
C1 [Vann, Richard D.; Moon, Richard E.] Duke Univ, Med Ctr, Ctr Hyperbar Med & Environm Physiol, Durham, NC 27710 USA.
   [Vann, Richard D.; Moon, Richard E.] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA.
   [Butler, Frank K.] USA, Inst Surg Res, San Antonio, TX USA.
   [Mitchell, Simon J.] Univ Auckland, Dept Anaesthesiol, Auckland 1, New Zealand.
RP Vann, RD (reprint author), Duke Univ, Med Ctr, Ctr Hyperbar Med & Environm Physiol, Box 3823, Durham, NC 27710 USA.
EM richard.vann@duke.edu
FU US Navy; Divers Alert Network
FX The authors received no revenue in support for this manuscript. RDV and
   REM received research grant funding from the US Navy. A portion of RDV's
   salary is paid by the Divers Alert Network. All other authors declare
   that they have no conflicts of interest.
NR 145
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U1 6
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0140-6736
J9 LANCET
JI Lancet
PD JAN 8
PY 2011
VL 377
IS 9760
BP 153
EP 164
DI 10.1016/S0140-6736(10)61085-9
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA 707NH
UT WOS:000286292800028
PM 21215883
ER

PT J
AU Wondmagegn, WT
   Satyala, NT
   Stiegler, HJ
   Quevedo-Lopez, MA
   Forsythe, EW
   Pieper, RJ
   Gnade, BE
AF Wondmagegn, W. T.
   Satyala, N. T.
   Stiegler, H. J.
   Quevedo-Lopez, M. A.
   Forsythe, E. W.
   Pieper, R. J.
   Gnade, B. E.
TI Simulation based performance comparison of transistors designed using
   standard photolithographic and coarse printing design specifications
SO THIN SOLID FILMS
LA English
DT Article
DE Photolithography; Inkjet printing; Pentacene; Performance; Switching
   speed; Channel on-resistance; Gate capacitance
ID THIN-FILM TRANSISTORS; FIELD-EFFECT TRANSISTORS; LARGE-AREA; POLYMER;
   ELECTRONICS; FABRICATION; INTEGRATION; RESISTANCE; RESOLUTION; PENTACENE
AB In this work a simulation based comparative study of organic field effect transistors designed using standard lithographic and printing designs is presented. The device simulations were performed using two-dimensional drift-diffusion equations with a Poole-Frenkel field dependent mobility model. Both photolithographic and coarse printing transistor designs employed common materials such as 150 nm thick pentacene, 150 nm thick parylene gate insulator, gold source-drain electrodes and aluminum gate electrodes. The major differences between the two fabrication specifications are the minimum source/drain line width and the transistor channel length. The typical specifications for the minimum line width and channel length were 2 mu m and 5 mu m for photolithography and 25 mu m and 20 mu m for coarse printing techniques, respectively. The gate, source, and drain capacitances and channel on-resistances at various channel lengths and gate overlaps have been extracted and presented specifically for both process schemes. Due to increased channel length and gate-source/drain overlap of printed electrodes relative to lithographic design, the resulting on-resistance and capacitances for coarse printing are significantly higher. These results demonstrate a substantial operating frequency reduction for printing design relative to photolithographic design. For the tested materials and designs it is shown that the cut-off frequency for the photolithographic process was 400 kHz but decreased to a much lower 26 kHz for the coarse printing process. Since printing technology uses various other materials, which typically have less performance than the ones used for this simulation, the actual printed device might have even lower performance than predicted here. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wondmagegn, W. T.; Satyala, N. T.; Pieper, R. J.] Univ Texas Tyler, Dept Elect Engn, Tyler, TX 75799 USA.
   [Stiegler, H. J.; Quevedo-Lopez, M. A.; Gnade, B. E.] Univ Texas Dallas Richardson, Dept Mat Sci & Engn, Richardson, TX 75080 USA.
   [Forsythe, E. W.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Wondmagegn, WT (reprint author), Univ Texas Tyler, Dept Elect Engn, 3900 Univ Blvd, Tyler, TX 75799 USA.
EM wwondmagegn@uttyler.edu
RI Gnade, Bruce/C-2327-2008
FU Department of Defense (Army Research Office) [W911NF-07-2-0059]
FX We gratefully acknowledge the Department of Defense for supporting this
   work (Army Research Office Contract W911NF-07-2-0059).
NR 47
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U1 1
U2 8
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0040-6090
J9 THIN SOLID FILMS
JI Thin Solid Films
PD JAN 3
PY 2011
VL 519
IS 6
BP 1943
EP 1949
DI 10.1016/j.tsf.2010.10.020
PG 7
WC Materials Science, Multidisciplinary; Materials Science, Coatings &
   Films; Physics, Applied; Physics, Condensed Matter
SC Materials Science; Physics
GA 721FM
UT WOS:000287339000030
ER

PT B
AU Carhart, T
AF Carhart, Tom
BE Burton, OV
   Podair, J
   Weber, JL
TI The Wrongful Court-Martial and Posthumous Presidential Pardon of
   Lieutenant Henry O. Flipper, USMA 1877
SO STRUGGLE FOR EQUALITY: ESSAYS ON SECTIONAL CONFLICT, THE CIVIL WAR, AND
   THE LONG RECONSTRUCTION
LA English
DT Article; Book Chapter
C1 USA, Washington, DC 20310 USA.
RP Carhart, T (reprint author), USA, Washington, DC 20310 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU UNIV PRESS VIRGINIA
PI CHARLOTTESVILLE
PA P O BOX 400318,, CHARLOTTESVILLE, VA 22904-4318 USA
BN 978-0-8139-3177-7
PY 2011
BP 183
EP 197
PG 15
WC History
SC History
GA BCH39
UT WOS:000310201500013
ER

PT S
AU Spradling, KD
   Dillman, JF
AF Spradling, Kimberly D.
   Dillman, James F., III
BE Fishbein, JC
TI THE MOLECULAR TOXICOLOGY OF CHEMICAL WARFARE NERVE AGENTS
SO ADVANCES IN MOLECULAR TOXICOLOGY, VOL 5
SE Advances in Molecular Toxicology
LA English
DT Article; Book Chapter
ID SOMAN-INDUCED SEIZURES; BLOOD-BRAIN-BARRIER; GENE-EXPRESSION PROFILES;
   TEMPORAL-LOBE EPILEPSY; RAT-BRAIN; OXIDATIVE STRESS; KAINIC ACID;
   PYRIDOSTIGMINE BROMIDE; MICROARRAY TECHNOLOGY; STATUS EPILEPTICUS
AB Chemical warfare nerve agents continue to be a threat to both military personnel and civilian populations. Organophosphorus nerve agents irreversibly inhibit the enzyme acetylcholinesterase, resulting in accumulation of high levels of the neurotransmitter acetylcholine (ACh) at muscarinic and nicotinic receptors. This accumulation of ACh induces clinical symptoms including myosis, difficulty in breathing, convulsions, seizures, and can result in death. Current medical countermeasures for treating nerve agent intoxication increase survival if administered rapidly after exposure but may not fully prevent brain injury. The downstream neurological damage induced by nerve agent exposure is not well characterized. Researchers are now utilizing molecular approaches to understand the molecular pathways involved in nerve agent-induced brain injury, with the goal of developing treatment strategies that are effective when administered after the onset of seizures and secondary responses that lead to nerve agent-induced brain injury.
C1 [Spradling, Kimberly D.; Dillman, James F., III] USA, Med Res Inst Chem Def, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Dillman, JF (reprint author), USA, Med Res Inst Chem Def, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA.
EM james.dillman@us.army.mil
NR 106
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U1 1
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1872-0854
BN 978-0-44-453865-9
J9 ADV MOLEC TOXICOL
PY 2011
VL 5
BP 111
EP 144
DI 10.1016/B978-0-444-53864-2.00003-7
PG 34
WC Biochemistry & Molecular Biology; Toxicology
SC Biochemistry & Molecular Biology; Toxicology
GA BCQ19
UT WOS:000310992300004
ER

PT J
AU Mei, YH
   Ibitayo, D
   Chen, X
   Lu, SS
   Lu, GQ
AF Mei, Yunhui
   Ibitayo, Dimeji
   Chen, Xu
   Lu, Susan
   Lu, Guo-Quan
BE Bi, K
   Shi, D
   Zhang, J
TI Migration of Sintered Nanosilver Die-attach Material on Alumina
   Substrate at High Temperatures
SO 2011 12TH INTERNATIONAL CONFERENCE ON ELECTRONIC PACKAGING TECHNOLOGY
   AND HIGH DENSITY PACKAGING (ICEPT-HDP)
LA English
DT Proceedings Paper
CT 12th International Conference on Electronic Packaging Technology and
   High Density Packaging (ICEPT-HDP)
CY AUG 08-11, 2011
CL Shanghai, PEOPLES R CHINA
SP IEEE, Chinese Inst Elect, IEEE Components, Packaging & Mfg Technol Soc (CPMT), Chinese Inst Elect, Elect Mfg & Packaging Technol Soc (EMPT), Shanghai Univ, ASTRI, Tsinghua Univ, Fudan Univ, Huazhong Univ Sci & Technol, Shanghai Jiao Tong Univ, Xidian Univ
DE High-temperature die-attach; Low-temperature sintering; Nanosilver
   paste; Silver migration
ID SILVER MIGRATION; PASTE; AG
AB A nanoscale silver paste that can be sintered at temperatures below 300 degrees C without external pressure is emerging as a promising die-attach material for implementing the low-temperature joining technology in high-temperature packaging. In this paper, we report our findings on silver migration in sintered nanosilver electrode-pair patterns on alumina substrate. The electrode pairs were biased at electric field ranging from 10 to 100 V/mm and at temperature between 250 degrees C and 400 degrees C in dry air. Leakage currents across the electrodes were measured as the silver patterns were tested in an oven. Silver dendrites formed across the electrode gap were observed under an optical microscope and analyzed using scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). Silver migration was found in samples tested at 400 degrees C, 350 degrees C, and 300 degrees C, and 250 degrees C. The measurements on leakage current vs. time were characterized by an initial incubation period, called "lifetime", followed by a sharp rise as silver dendrites were shorting the electrodes. A rapid rise in the "lifetime" with decreasing oxygen partial pressure was also found. A simple phenomenological model was derived to account for the observed dependence of "lifetime" on electric field temperature, and oxygen partial pressure. The reliability or sintered nanosilver die-attachment over silver migration in high temperature applications can be significantly improved through packaging or encapsulation to reduce oxygen exposure.
C1 [Mei, Yunhui] Tianjin Univ, Tianjin Key Lab Adv Joining Technol, Tianjin 300072, Peoples R China.
   [Mei, Yunhui] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China.
   [Ibitayo, Dimeji] US Army, Res Lab, Sch Chem Engn, Adelphi, MD USA.
   [Chen, Xu] Tianjin Univ, Sch Chem Engn, Tianjin, Peoples R China.
   [Lu, Susan] LLC, NBE Technol, Blacksburg, VA 24061 USA.
   [Lu, Guo-Quan] Virginia Polytech Inst State Univ, Dept Mat Sci & Engn, Blacksburg, VA USA.
RP Mei, YH (reprint author), Tianjin Univ, Tianjin Key Lab Adv Joining Technol, Tianjin 300072, Peoples R China.
EM gqlu@vt.edu
RI Lu, Guo-Quan/N-3661-2013; Mei, Yunhui/N-1095-2013
OI Mei, Yunhui/0000-0002-6508-4343
FU United States Army Research Laboratory [W911NF-07-R-000I]; Chinese
   National Science Foundation (NSFC) [50528506]
FX The authors are grateful to financial support provided by the United
   States Army Research Laboratory under Contract No. W911NF-07-R-000I and
   Chinese National Science Foundation (NSFC) (No. 50528506).
NR 25
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Z9 0
U1 0
U2 3
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4577-1768-0
PY 2011
BP 787
EP 792
PG 6
WC Engineering, Electrical & Electronic
SC Engineering
GA BCC84
UT WOS:000309781000171
ER

PT S
AU Scozzie, CJ
   Lelis, AJ
   Green, R
AF Scozzie, C. J.
   Lelis, A. J.
   Green, R.
BE Shenai, K
   Garg, R
   Ma, R
   Dudley, M
   Khan, A
TI Reliability-Driven SiC Power Device Development for Army Applications
SO GALLIUM NITRIDE AND SILICON CARBIDE POWER TECHNOLOGIES
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on GaN and SiC Power Technologies held during the 220th
   Meeting of the Electrochemical-Society
CY OCT 09-14, 2011
CL Boston, MA
SP Electrochem Soc, Dielect Sci & Technol, Elect & Photon
AB The Army is incorporating more and more electronic functionality into its vehicle platforms by converting many hydraulic functions to electronic to allow better power management, performance, and fuel efficiency. Because of high operating temperature (80 degrees-110 degrees C coolant), reliability, and efficiency requirements for these future power electronic systems, silicon carbide (SiC) technology has been under investigation by the Army since 1992. Since a recent demonstration by the Army Research Laboratory (ARL) of a 900-A power module implemented using 1200 V / 80 A SiC MOSFETs has confirmed SiC's high-temperature and high-efficiency advantage over silicon IGBT switches, the assessment of reliability and qualification of these SiC MOSFETs has become an imperative focus. Initial investigation of these large-area 80-A SiC MOSFET die shows that there is a threshold instability that is accelerated at junction temperatures of 150 degrees C and greater and may affect long-term reliability for 10,000-15,000 hr operation. Further, initial attempt at using Si industry reliability standards to qualify these SiC MOSFETs suggests that such standards may need to be modified.
C1 [Scozzie, C. J.; Lelis, A. J.; Green, R.] USA, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Scozzie, CJ (reprint author), USA, Sensor & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
NR 13
TC 0
Z9 0
U1 0
U2 4
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-262-2
J9 ECS TRANSACTIONS
PY 2011
VL 41
IS 8
BP 9
EP 15
DI 10.1149/1.3631481
PG 7
WC Electrochemistry; Engineering, Electrical & Electronic; Physics, Applied
SC Electrochemistry; Engineering; Physics
GA BCB39
UT WOS:000309600300002
ER

PT S
AU Lelis, A
   Green, R
   Habersat, D
AF Lelis, A.
   Green, R.
   Habersat, D.
BE Shenai, K
   Garg, R
   Ma, R
   Dudley, M
   Khan, A
TI Effect of Threshold-Voltage Instability on SiC Power MOSFET
   High-Temperature Reliability
SO GALLIUM NITRIDE AND SILICON CARBIDE POWER TECHNOLOGIES
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on GaN and SiC Power Technologies held during the 220th
   Meeting of the Electrochemical-Society
CY OCT 09-14, 2011
CL Boston, MA
SP Electrochem Soc (ECS), Dielect Sci & Technol, Elect & Photon
ID PERFORMANCE; DEPENDENCE; STRESS
AB A review of recent work on the effect of threshold-voltage instability on the reliability of SiC power MOSFETs is presented. Significant increases in the instability of the I-D-V-GS characteristics due to ON-state current stressing are similar in nature to increases caused by high-temperature bias stressing. Devices stressed by elevated temperature alone exhibited very little instability compared with devices stressed with both temperature and applied bias. These results, along with other results in the literature, suggest that this increase in threshold voltage instability at elevated temperature is due to the activation of additional near-interfacial gate oxide traps related to an O-vacancy defect known as an E' center. It is important to develop improved processing methods to decrease the number of precursor oxide defect sites, since an increased negative shift can give rise to increased leakage current in the OFF-state and potential device failure if proper precautions are not met to provide an adequate margin for the threshold voltage.
C1 [Lelis, A.; Green, R.; Habersat, D.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Lelis, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
NR 25
TC 11
Z9 11
U1 1
U2 6
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-262-2
J9 ECS TRANSACTIONS
PY 2011
VL 41
IS 8
BP 203
EP 214
DI 10.1149/1.3631498
PG 12
WC Electrochemistry; Engineering, Electrical & Electronic; Physics, Applied
SC Electrochemistry; Engineering; Physics
GA BCB39
UT WOS:000309600300019
ER

PT S
AU Green, R
   Lelis, AJ
   Habersat, D
AF Green, R.
   Lelis, A. J.
   Habersat, D.
BE Shenai, K
   Garg, R
   Ma, R
   Dudley, M
   Khan, A
TI Implications for Robust Reliability Testing of Power SiC MOSFETs
SO GALLIUM NITRIDE AND SILICON CARBIDE POWER TECHNOLOGIES
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on GaN and SiC Power Technologies held during the 220th
   Meeting of the Electrochemical-Society
CY OCT 09-14, 2011
CL Boston, MA
SP Electrochem Soc, Dielect Sci & Technol, Elect & Photon
ID PERFORMANCE
AB Threshold voltage (V-T) instability remains an important issue for the performance, reliability, and qualification of large-area SiC power MOSFET devices. The direct application of existing reliability test standards to SiC power MOSFETs can in some cases result in an inconsistent pass/fail response for a given device. Significant variations in the I-D-V-GS characteristics, with accompanying shift in V-T and change in leakage current, can result when these prescribed standards are applied as written. These variations are likely due to the complex time, temperature, and bias dependent nature of the charging and discharging of significant numbers of near-interfacial oxide traps that exists in as-processed SiC MOSFET devices. The significant increase in this V-T instability at elevated temperature may suggest the activation of additional performance limiting oxide defects. If the negative shift in V-T is large enough, it may increase the OFF-state drain leakage current and limit the long-term device reliability.
C1 [Green, R.; Lelis, A. J.; Habersat, D.] USA, Power Components Branch, Res Lab, Adelphi, MD 20783 USA.
RP Green, R (reprint author), USA, Power Components Branch, Res Lab, Adelphi, MD 20783 USA.
NR 11
TC 0
Z9 0
U1 1
U2 3
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-262-2
J9 ECS TRANSACTIONS
PY 2011
VL 41
IS 8
BP 215
EP 224
DI 10.1149/1.3631499
PG 10
WC Electrochemistry; Engineering, Electrical & Electronic; Physics, Applied
SC Electrochemistry; Engineering; Physics
GA BCB39
UT WOS:000309600300020
ER

PT S
AU Meyer, CD
   Bedair, SS
   Xue, L
   Dougherty, CM
   Bashirullah, R
   Arnold, DP
   Morgan, BC
AF Meyer, C. D.
   Bedair, S. S.
   Xue, L.
   Dougherty, C. M.
   Bashirullah, R.
   Arnold, D. P.
   Morgan, B. C.
BE Shenai, K
   Garg, R
   Ma, R
   Dudley, M
   Khan, A
TI Integrated Power Inductors and Capacitors Enabled by a Multilevel
   Molding Process
SO GALLIUM NITRIDE AND SILICON CARBIDE POWER TECHNOLOGIES
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on GaN and SiC Power Technologies held during the 220th
   Meeting of the Electrochemical-Society
CY OCT 09-14, 2011
CL Boston, MA
SP Electrochem Soc, Dielect Sci & Technol, Elect & Photon
AB We summarize here recent advancements toward integration of electronic passives for electrical power converters. Microscale inductors and capacitors with three-dimensional, free-standing copper traces are formed via a multi-layer molding and electroplating process. This capability creates two complementary routes for passives microfabrication: (a) high inductance density air-core inductors with vertically-stacked windings; and (b) inductors and capacitors with ferromagnetic and dielectric nanoparticles deposited through capillary-driven self-assembly. Several designs of air-core inductors are tested with inductance densities >100 nH/mm(2) and quality factors >20. A suspended transmission line is encapsulated in NiFe2O4 magnetic nanoparticles for 25% greater inductance and no detriment to the quality factor up to 100 MHz. Deposition of BaTiO3 dielectric nanoparticles between nested capacitor electrodes yields up to a 6x increase in capacitance.
C1 [Meyer, C. D.; Bedair, S. S.; Morgan, B. C.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Meyer, CD (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RI Bedair, Sarah/D-9130-2013; 
OI Dougherty, Christopher/0000-0001-7302-5573
NR 13
TC 0
Z9 0
U1 0
U2 4
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-262-2
J9 ECS TRANSACTIONS
PY 2011
VL 41
IS 8
BP 331
EP 340
DI 10.1149/1.3631509
PG 10
WC Electrochemistry; Engineering, Electrical & Electronic; Physics, Applied
SC Electrochemistry; Engineering; Physics
GA BCB39
UT WOS:000309600300030
ER

PT S
AU Borodin, O
   Jow, TR
AF Borodin, Oleg
   Jow, T. Richard
BE Lucht, B
   Henderson, WA
   Jow, TR
   Ue, M
TI Quantum Chemistry Studies of the Oxidative Stability of Carbonate,
   Sulfone and Sulfonate-Based Electrolytes Doped with BF4-, PF6- Anions
SO NON-AQUEOUS ELECTROLYTES FOR LITHIUM BATTERIES
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on Non-Aqueous Electrolytes for Lithium Batteries held during
   the 218th Meeting of the Electrochemical-Society
CY OCT 10-15, 2010
CL Las Vegas, NV
SP Electrochem Soc, Battery, Energy Technol
ID LITHIUM ION BATTERY; ELECTROCHEMICAL PROPERTIES; POTENTIALS; ADDITIVES;
   SOLVENTS; SALTS
AB Quantum chemistry studies of the oxidative stability of carbonate, sulfonate and sulfone-based solvents with and without BF4-, PF6- anions were performed using M05-2X Minnesota density functional and cc-pvTz basis set. Presence of BF4- and PF6- anions was found to significantly decrease oxidative stability of a number of carbonate solvents such as ethylene carbonate, dimethyl carbonate and propylene carbonate via HF formation. Oxidation of the tetramethyl sulfone/BF4- and propargyl methanesulfonate/PF6- complexes resulted in the fluorine transfer to the solvent. Oxidation of the tetramethyl sulfone/BF4- complex also resulted in a spontaneous ring opening. No water was needed to form PF5 and BF3 upon oxidation of the solvent/BF4- and solvent/PF6- complexes. Density functional estimates of the solvent/anion oxidative stability were found in good agreement with available experimental data for non-active electrodes after polarized continuum model was utilized to implicitly account for the surrounding solvent dielectric permittivity.
C1 [Borodin, Oleg; Jow, T. Richard] Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
RP Borodin, O (reprint author), Army Res Lab, Electrochem Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 16
TC 22
Z9 25
U1 1
U2 16
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-238-7
J9 ECS TRANSACTIONS
PY 2011
VL 33
IS 28
BP 77
EP 84
DI 10.1149/1.3563092
PG 8
WC Electrochemistry
SC Electrochemistry
GA BCA93
UT WOS:000309519200008
ER

PT S
AU Grinfeld, MA
   Segletes, SB
AF Grinfeld, Michael A.
   Segletes, Steven B.
BE Ouyang, H
TI Analogies between Theories of Phase Transformations and Damage in Velcro
   Modelling
SO 9TH INTERNATIONAL CONFERENCE ON DAMAGE ASSESSMENT OF STRUCTURES (DAMAS
   2011)
SE Journal of Physics Conference Series
LA English
DT Proceedings Paper
CT 9th International Conference on Damage Assessment of Structures (DAMAS)
CY JUL 11-13, 2011
CL Univ Oxford, St Annes Coll, Oxford, ENGLAND
HO Univ Oxford, St Annes Coll
ID MORPHOLOGICAL INSTABILITIES; BRITTLE-FRACTURE
AB There is a deep analogy between the theory of phase transformation and various theories of damage. The analogy is reflected in the corresponding mathematical techniques - both phenomena lead to a deeply nonlinear boundary value problem with free boundaries. This principal mechanism of nonlinearity occurs even for physically and mechanically linear equations of states. It can be understood and illustrated even on the particularly simple examples relating to unzipping in Velcro systems, which are of practical interest on their own.
C1 [Grinfeld, Michael A.; Segletes, Steven B.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Grinfeld, MA (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM mgreenfield@arl.army.mil; ssegletes@arl.army.mil
NR 17
TC 0
Z9 0
U1 2
U2 2
PU IOP PUBLISHING LTD
PI BRISTOL
PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND
SN 1742-6588
J9 J PHYS CONF SER
PY 2011
VL 305
AR 012036
DI 10.1088/1742-6596/305/1/012036
PG 10
WC Engineering, Mechanical; Physics, Applied
SC Engineering; Physics
GA BCB88
UT WOS:000309681100032
ER

PT S
AU Grew, KN
   Ren, XM
   Chu, DR
AF Grew, Kyle N.
   Ren, Xiaoming
   Chu, Deryn
BE Gasteiger, HA
   Weber, A
   Narayanan, SR
   Jones, D
   Strasser, P
   SwiderLyons, K
   Buchi, FN
   Shirvanian, P
   Nakagawa, H
   Uchida, H
   Mukerjee, S
   Schmidt, TJ
   Ramani, V
   Fuller, T
   Edmundson, M
   Lamy, C
   Mantz, R
TI Effect of CO2 on the Alkaline Membrane Fuel Cell
SO POLYMER ELECTROLYTE FUEL CELLS 11
SE ECS Transactions
LA English
DT Proceedings Paper
CT 11th Polymer Electrolyte Fuel Cell Symposium (PEFC) Under the Auspices
   of the 220th Meeting of the ECS
CY OCT, 2011
CL Boston, MA
SP ECS, Energy Technol (ETD), Phys & Analyt Electrochem (PAED), Battery (BATT), Ind Electrochem & Electrochem Engn (IEEE), Corros (CORR)
ID ANION-EXCHANGE MEMBRANES; METHANOL OXIDATION; MEDIA; PERFORMANCE;
   HYDROXIDE
AB Alkaline solutions can undergo the conversion of hydroxide (OH-) to carbonate (CO3=) and bicarbonate (HCO3-) in the presence of carbon dioxide (CO2). This presents a challenge to the Alkaline Membrane Fuel Cell (AMFC), where CO2 may be introduced via an atmospheric air oxidant and as a reaction product of alcohol fuels. CO2 has several implications on the AMFC, including the exchange of OH- counterions in the anion exchange (AE) membrane and ionomer for the larger, less mobile (bi)carbonates. The (bi)carbonates may be purged during operation; however, their presence can decrease the ionic conductivity and effect the thermodynamics and electrochemical kinetics. These processes make component and cell characterization difficult and subjective to the environmental and operational history of the materials and cells. The interactions of CO2 with the AE membrane are needed and examined in this work.
C1 [Grew, Kyle N.; Ren, Xiaoming; Chu, Deryn] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RP Grew, KN (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA.
RI Grew, Kyle/K-3982-2013
OI Grew, Kyle/0000-0002-1645-3835
NR 13
TC 1
Z9 1
U1 5
U2 15
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-255-4
J9 ECS TRANSACTIONS
PY 2011
VL 41
IS 1
BP 1979
EP 1985
DI 10.1149/1.3635727
PG 7
WC Electrochemistry; Energy & Fuels; Polymer Science
SC Electrochemistry; Energy & Fuels; Polymer Science
GA BCB37
UT WOS:000309598800189
ER

PT S
AU Shen, H
   Sampath, AV
   Zhou, Q
   Campbell, J
   Wraback, M
AF Shen, H.
   Sampath, A. V.
   Zhou, Q.
   Campbell, J.
   Wraback, M.
BE Overberg, ME
   LaRoche, J
   Mishra, K
   Johnson, W
TI Effect of Interface Polarization Charge on GaN/SiC Separate Absorption
   and Multiplication Avalanche Photodiodes
SO STATE-OF-THE-ART PROGRAM ON COMPOUND SEMICONDUCTORS 53 (SOTAPOCS 53)
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on State-of-the-Art Program on Compound Semiconductors 53
   (SOTAPOCS) held during the 220th Meeting of the Electrochemical-Society
   (ECS)
CY OCT 09-14, 2011
CL Boston, MA
SP Electrochem Soc (ECS), Elect & Photon, Luminescence & Display Mat
AB A III-Nitride/SiC separate absorption and multiplication avalanche photodiode (SAM-APD) offers a novel approach for fabricating high gain photodetectors with tunable absorption over a wide spectrum from the visible to deep ultraviolet. However, unlike conventional heterojunction SAM APDs, the formation of polarization-induced charge at the hetero-interface arising from spontaneous and piezoelectric polarization can dramatically affect the performance of this detector. In this paper we report on the role of this interface charge on the performance of GaN/SiC SAM APDs.
C1 [Shen, H.; Sampath, A. V.; Wraback, M.] USA, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA.
RP Shen, H (reprint author), USA, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
NR 7
TC 0
Z9 0
U1 2
U2 12
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-60768-260-8
J9 ECS TRANSACTIONS
PY 2011
VL 41
IS 6
BP 81
EP 87
DI 10.1149/1.3629956
PG 7
WC Electrochemistry; Nanoscience & Nanotechnology; Physics, Applied
SC Electrochemistry; Science & Technology - Other Topics; Physics
GA BCB08
UT WOS:000309536900008
ER

PT S
AU Boc, SJ
   Hathaway, KK
AF Boc, S. J.
   Hathaway, K. K.
BE Benassai, G
   Brebbia, CA
   Rodriguez, G
TI Pacific Island Land Ocean Typhoon (PILOT) experiment
SO COASTAL PROCESSES II
SE WIT Transactions on Ecology and the Environment
LA English
DT Proceedings Paper
CT 2nd International Conference on Physical Coastal Processes, Management
   and Engineering
CY APR 27-29, 2011
CL Naples, ITALY
SP Univ Las Palmas, Wessex Inst Technol, Univ Parthenope, WIT, Transact Ecol & Environm, ASCE UK Grp
DE reefs; waves; surge; wave setup; hurricane; wave-reef interaction
AB The PILOT program sponsored by the U.S. Army Corps of Engineers is designed to acquire data necessary to depict and better understand the physics of the wave-reef interaction. Field sites have been instrumented on the islands of Guam, Oahu and St. Croix. Guam and St. Croix were selected primarily because of their potential of being affected by tropical cyclones annually. In addition, they offer different reef characteristics with favourable physical and logistical settings to study waves, currents, and water levels over reefs. Data were collected from a nearby deep-water directional wave buoy, coastal water-level and meteorological stations, shallow water wave gauges on the reef flats, and a laser-based bathymetric survey. Two storm events were recorded during a St Croix deployment (10 August to 11 November 2008); the first, a swell event, and the second, a wind-sea event, were investigated for different wave transformations over the reef. The first even occurred 30 September-1 October 2008, with a large swell recorded at the offshore Waverider buoy and low wind speeds (similar to 7 mph E-ENE) measured at the St Croix airport. Incident wave heights peaked at 2.7 m with peak periods of approximately 15 s, and an incident direction of 47 degrees (compass direction from true north). This even produced the largest waves observed over the reef in this deployment. Mean water level (setup/surge) was about 0.2 m above normal. The second event occurred with the passing of Hurricane Omar on 16 October 2008. Incident waves (wind seas) peaked at 4.4 m with peak periods of nearly 8 s and directions from about 36 degrees. Although the incident waves were substantially higher, 4.4 m vs. 2.7 m, the peak wave heights over the reef were lower, 0.55 m vs. 0.72 m. Wave energy on the reef was primarily in the infragravity band (20 s-120 s). Surge and setup were similar and only about 0.2 m.
C1 [Boc, S. J.; Hathaway, K. K.] USA, Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
RP Boc, SJ (reprint author), USA, Corps Engineers, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA.
NR 5
TC 0
Z9 0
U1 0
U2 1
PU WIT PRESS
PI SOUTHAMPTON
PA ASHURST LODGE, SOUTHAMPTON SO40 7AA, ASHURST, ENGLAND
SN 1743-3541
BN 978-1-84564-534-2
J9 WIT TRANS ECOL ENVIR
JI WIT Trans. Ecol. Environ.
PY 2011
VL 149
BP 151
EP 162
DI 10.2495/CP110131
PG 12
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA BCA36
UT WOS:000309430200013
ER

PT S
AU Anton, CM
   Ervin, MH
AF Anton, C. M.
   Ervin, M. H.
BE Zaghib, K
   Julien, C
   Ramani, V
TI Flexible Carbon Nanotube and Paper Electrochemical Double Layer
   Capacitors using PVA-KOH Gel Electrolytes
SO ELECTROCHEMISTRY OF NOVEL MATERIALS FOR ENERGY STORAGE AND CONVERSION
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on Electrochemistry of Novel Materials for Energy Storage and
   Conversion held during the 218th Meeting of the Electrochemical-Society
CY OCT 10-15, 2010
CL Las Vegas, NV
SP Energy Technol, Electrochem Soc
ID SUPERCAPACITORS; POLYMER
AB Electrochemical double layer capacitors are fabricated using CNT/paper flexible electrodes. An extensive electrode fabrication study was conducted, resulting in single electrode specific capacitances in excess of 100 F/g. Surfactants and dispersants in the CNT suspension prior to CNT deposition onto paper substrates were found to be detrimental to electrode performance. Following electrode fabrication, three full cell packaged supercapacitor architectures were investigated. One architecture utilized a liquid KOH electrolyte, while the other two architectures used a PVA:KOH gel electrolyte. Devices were tested under static bending conditions, and proved to function under bending.
C1 [Anton, C. M.; Ervin, M. H.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Anton, CM (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
NR 13
TC 1
Z9 1
U1 2
U2 23
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-56677-885-5
J9 ECS TRANSACTIONS
PY 2011
VL 33
IS 27
BP 117
EP 128
DI 10.1149/1.3565508
PG 12
WC Electrochemistry
SC Electrochemistry
GA BCA88
UT WOS:000309515600014
ER

PT S
AU Jow, TR
   Marx, M
   Allen, JL
AF Jow, T. Richard
   Marx, Michelle
   Allen, Jan L.
BE Liaw, BY
   Kostecki, R
   Trulove, P
TI Distinguishing Li+ Charge Transfer Kinetics at 1. NCA/Electrolyte and
   Graphite/Electrolyte Interfaces, and 2. NCA/Electrolyte and
   LFP/Electrolyte Interfaces in Li-ion Cells
SO ELECTRODE-ELECTROLYTE INTERFACES IN LI-ION BATTERIES
SE ECS Transactions
LA English
DT Proceedings Paper
CT Symposium on Electrode-Electrolyte Interfaces in Li-Ion Batteries held
   during the 218th Meeting of the Electrochemical-Society (ECS)
CY OCT 10-15, 2010
CL Las Vegas, NV
SP Electrochem Soc (ECS), Battery, Phys & Analyt Electrochem
ID PULSED-LASER DEPOSITION; BATTERIES; ELECTROLYTES
AB In examining the Li+ charge transfer kinetics at the graphite anode and the lithium nickel cobalt aluminum oxide, LiNi0.80Co0.15Al0.05O2 (NCA), cathode in a complete cell, we found that the activation energy, E-a, for the charge transfer at the graphite/electrolyte interface is about 68 kJ/mol, which is consistent with the recently reported values. However, the E-a for the charge transfer at the NCA/electrolyte interface is about 50 kJ/mol, which is lower than that at the graphite anode. With desolvation as the predominate step for limiting the kinetics and both of the electrodes were subject to the same electrolyte, the difference in Ea suggests that the E-a is influenced greatly with respect to the nature of electrode materials and their associated SEIs. This is further confirmed by the examination of the LiFePO4 (LFP)/electrolyte and the graphite/electrolyte interfaces using a LFP/graphite complete cell.
C1 [Jow, T. Richard; Marx, Michelle; Allen, Jan L.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Jow, TR (reprint author), USA, Res Lab, Adelphi, MD 20783 USA.
NR 13
TC 0
Z9 0
U1 2
U2 13
PU ELECTROCHEMICAL SOC INC
PI PENNINGTON
PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA
SN 1938-5862
BN 978-1-56677-879-4
J9 ECS TRANSACTIONS
PY 2011
VL 33
IS 23
BP 1
EP 13
DI 10.1149/1.3557697
PG 13
WC Electrochemistry
SC Electrochemistry
GA BCA49
UT WOS:000309451600001
ER

PT J
AU Henning, JS
   Fazio, MG
AF Henning, Jeffrey S.
   Fazio, Michael G.
TI Yellowish Papules on a Middle-aged Man
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Editorial Material
ID ERUPTIVE XANTHOMAS
C1 [Henning, Jeffrey S.] San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA.
   [Fazio, Michael G.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Henning, JS (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA.
EM jeffrey.henning@amedd.army.mil
NR 8
TC 1
Z9 1
U1 0
U2 0
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD JAN 1
PY 2011
VL 83
IS 1
BP 73
EP 74
PG 2
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA 005UF
UT WOS:000308774900008
PM 21888131
ER

PT J
AU Solomon, NP
   Helou, LB
   Stojadinovic, A
AF Solomon, Nancy Pearl
   Helou, Leah B.
   Stojadinovic, Alexander
TI Clinical Versus Laboratory Ratings of Voice Using the CAPE-V
SO JOURNAL OF VOICE
LA English
DT Article
DE Perceptual ratings; Voice quality; Reliability; CAPE-V; Thyroidectomy
ID AUDITORY-PERCEPTUAL EVALUATION; VISUAL ANALOG SCALE; DYSPHONIC VOICE;
   GRBAS SCALE; THYROID-SURGERY; QUALITY; RELIABILITY; LISTENERS;
   EXPERIENCE
AB Objectives. Procedures used for auditory-perceptual assessment of voice in the clinical setting often differ from those used in research settings. This study examined whether ratings made with the knowledge of a patient's identity and clinical status are consistent with those made under randomized and blinded laboratory conditions.
   Study Design. Data derived from a prospective observational clinical trial were used in this mixed laboratory (blinded, randomized, anchored) and field (clinical) correlational study.
   Methods. Ninety-nine adults scheduled for thyroidectomy were evaluated by one of two speech-language pathologists (SLPs) using the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) before and up to three times after surgery over a 6-month period. Subsequently, voice recordings were played over headphones in randomized order within speaker to three experienced SLPs, including the two who conducted clinical ratings. Listeners were blinded to speaker identity and recording session, and were provided with auditory anchors for "moderate" dysphonia.
   Results. Each of the two SLPs who rated the speakers' voices clinically demonstrated moderately strong correlations with ratings of the same voices under laboratory conditions (r = 0.807 and 0.708 for overall severity), but clinical ratings tended to be higher (more severe) than laboratory ratings particularly when dysphonia was moderate to severe. Intraclass correlations across the three SLPs for laboratory ratings were moderate (r = 0.645 for overall severity). Correlations between clinical and the median of the three laboratory ratings across all sessions were moderate (r = 0.526-0.792), with the strongest correlation for overall severity.
   Conclusions. Clinical bias may play a role in observed discrepancies between clinical and laboratory ratings of dysphonia. Additionally, auditory anchors available during laboratory procedures may contribute to these discrepancies. These findings highlight the need to standardize procedures for clinical voice assessment.
C1 [Solomon, Nancy Pearl] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA.
RP Solomon, NP (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA.
EM nancy.p.solomon@us.army.mil
FU Army Regional Anesthesia and Pain Management Initiative; Department of
   Surgery at Walter Reed Army Medical Center
FX This project was funded in part by the Army Regional Anesthesia and Pain
   Management Initiative and the Department of Surgery at Walter Reed Army
   Medical Center. We are grateful to Alessandro Contreras-Grassi for
   computer programming, Amanda Gillespie for listening expertise, and
   Robin Howard for statistical consultation. The views expressed in this
   article are those of the authors and do not necessarily reflect the
   official policy or position of the Department of the Army or U.S.
   Government. This study was presented in June 2009 at the 38th Annual
   Voice Foundation Symposium: Care of the Professional Voice,
   Philadelphia, PA.
NR 24
TC 15
Z9 17
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0892-1997
J9 J VOICE
JI J. Voice
PD JAN
PY 2011
VL 25
IS 1
BP E7
EP E14
DI 10.1016/j.jvoice.2009.10.007
PG 8
WC Otorhinolaryngology
SC Otorhinolaryngology
GA 992LG
UT WOS:000307777000002
PM 20430573
ER

PT S
AU Sharp, MK
   Seda-Sanabria, Y
   Matheu, EE
AF Sharp, Michael K.
   Seda-Sanabria, Yazmin
   Matheu, Enrique E.
BE Cadoni, E
   DiPrisco, M
TI Recent efforts on blast damage mitigation for dams
SO PERFORMANCE, PROTECTION AND STRENGTHENING OF STRUCTURES UNDER EXTREME
   LOADING
SE Applied Mechanics and Materials
LA English
DT Proceedings Paper
CT 3rd International Workshop on Performance, Protection and Strengthening
   of Structures Under Extreme Loading
CY AUG 30-SEP 01, 2011
CL Lugano, SWITZERLAND
DE dam; lock; levee; blast; mitigation; threat; vulnerability; protection;
   recovery
AB This paper describes collaborative research efforts conducted between the U.S. Army Corps of Engineers (USACE) and the U.S. Department of Homeland Security (DHS). The USACE, through its U.S. Army Engineer Research and Development Center (ERDC), has focused efforts on the development of a collaborative research program to address technical gaps related to risk and blast mitigation for dams. These research efforts involve experimental and analytical tasks designed to improve blast damage prediction capabilities for dams, navigation locks, and levee systems resulting from vehicle and waterborne delivery scenarios. The outcomes from these efforts can inform USACE's priorities, which include refining the current understanding of the effects of potential attacks, the vulnerabilities and weaknesses of its critical assets to various threat conditions, and the local and regional consequences of those attacks in order to develop appropriate protective measures and recovery technologies.
C1 [Sharp, Michael K.] ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
   [Seda-Sanabria, Yazmin] SACE HQ, Washington 20314, DC USA.
   [Matheu, Enrique E.] Dept Homeland Secur, Arlington 20598, VA USA.
RP Sharp, MK (reprint author), ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Michael.K.Sharp@usace.army.mil; Yazmin.Seda-Sanabria@usace.army.mil;
   Enrique.Matheu@dhs.gov
NR 4
TC 4
Z9 4
U1 0
U2 1
PU TRANS TECH PUBLICATIONS LTD
PI DURNTEN-ZURICH
PA KREUZSTRASSE 10, 8635 DURNTEN-ZURICH, SWITZERLAND
SN 1660-9336
BN 978-3-03785-217-0
J9 APPL MECH MATER
PY 2011
VL 82
BP 428
EP +
DI 10.4028/www.scientific.net/AMM.82.428
PG 2
WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics
SC Engineering; Materials Science; Mechanics
GA BBB89
UT WOS:000306394700068
ER

PT S
AU Roppo, V
   Kalinowski, K
   Wang, W
   Cojocaru, C
   Trull, J
   Vilaseca, R
   Scalora, M
   Krolikowski, W
   Kivshar, Y
AF Roppo, V.
   Kalinowski, K.
   Wang, W.
   Cojocaru, C.
   Trull, J.
   Vilaseca, R.
   Scalora, M.
   Krolikowski, W.
   Kivshar, Yu
GP IEEE
TI Second-Harmonic Generation in Disordered Quadratic Media: Role of a
   Ferroelectric Domain Structure
SO 2010 12TH INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS
   (ICTON)
SE International Conference on Transparent Optical Networks-ICTON
LA English
DT Proceedings Paper
CT 12th International Conference on Transparent Optical Networks (ICTON)
CY JUN 27-JUL 01, 2010
CL Munich, GERMANY
SP IEEE, Tech Univ Munchen (TUM), IEEE Photon Soc, VDE, Informat Technol Soc (ITG)
DE nonlinear optics; harmonic generation; random media
ID SCATTERING; CRYSTALS
AB We study theoretically the second harmonic generation in a nonlinear quadratic crystal with random distribution of ferroelectric domains. We show that the specific features of disordered domain structure greatly affect the emission pattern of the generated harmonics. This phenomenon can be used to characterize the degree of disorder in nonlinear photonic structures.
C1 [Roppo, V.; Cojocaru, C.; Trull, J.; Vilaseca, R.] Univ Politecn Cataluna, ETSEIAT, Dept Fis & Engn Nucl, Colom 11, Barcelona 08222, Spain.
   [Roppo, V.; Kalinowski, K.; Wang, W.; Krolikowski, W.; Kivshar, Yu] Australian Natl Univ, Nonlinear Phys Ctr & Laser Phys Ctr, Res Sch Phys & Engn, Canberra, ACT 0200, Australia.
   [Scalora, M.] RDECOM, US Army Aviat & Missile Command, Res Facil, Redstone Arsenal, AL 35803 USA.
RP Roppo, V (reprint author), Univ Politecn Cataluna, ETSEIAT, Dept Fis & Engn Nucl, Colom 11, Barcelona 08222, Spain.
EM vito.roppo@upc.edu
RI Trull, Jose/L-9054-2014
OI Trull, Jose/0000-0002-5850-088X
NR 10
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 2162-7339
BN 978-1-4244-7798-2
J9 INT C TRANS OPT NETW
PY 2011
PG 3
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BBK10
UT WOS:000307108000216
ER

PT S
AU Lance, B
   Gordon, S
   Vettel, J
   Johnson, T
   Paul, V
   Manteuffel, C
   Jaswa, M
   Oie, K
AF Lance, Brent
   Gordon, Stephen
   Vettel, Jean
   Johnson, Tony
   Paul, Victor
   Manteuffel, Chris
   Jaswa, Matthew
   Oie, Kelvin
BE DMello, S
   Graesser, A
   Schuller, B
   Martin, JC
TI Classifying High-Noise EEG in Complex Environments for Brain-Computer
   Interaction Technologies
SO AFFECTIVE COMPUTING AND INTELLIGENT INTERACTION, PT II
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 4th Bi-Annual International Conference of the Humaine Association on
   Affective Computing and Intelligent Interaction (ACII 2011)
CY OCT 09-12, 2011
CL Memphis, TN
SP Univ Memphis, HUMAINE Assoc, FedEx Inst Techn, Inst Intelligent Syst, Aldebaran Robot
DE EEG; affect; self-relevant; classification; noise
ID INDEX; ATTENTION; SELF
AB Future technologies such as Brain-Computer Interaction Technologies (BCIT) or affective Brain Computer Interfaces (aBCI) will need to function in an environment with higher noise and complexity than seen in traditional laboratory settings, and while individuals perform concurrent tasks. In this paper, we describe preliminary results from an experiment in a complex virtual environment. For analysis, we classify between a subject hearing and reacting to an audio stimulus that is addressed to them, and the same subject hearing an irrelevant audio stimulus. We performed two offline classifications, one using BCILab [1], the other using LibSVM [2]. Distinct classifiers were trained for each individual in order to improve individual classifier performance [3]. The highest classification performance results were obtained using individual frequency bands as features and classifying with an SVM classifier with an RBF kernel, resulting in mean classification performance of 0.67, with individual classifier results ranging from 0.60 to 0.79.
C1 [Lance, Brent; Vettel, Jean; Oie, Kelvin] USA, Res Lab, Human Res & Engn Directorate, RDRL HRS C, Aberdeen Proving Ground, MD 20783 USA.
   [Gordon, Stephen; Johnson, Tony; Manteuffel, Chris; Jaswa, Matthew] DCS Corporation, Aberdeen Proving Ground, MD 20783 USA.
   [Paul, Victor] US Army, Tank & Automot Res, Ctr Dev & Engn, Aberdeen Proving Ground, MD 20783 USA.
RP Lance, B (reprint author), USA, Res Lab, Human Res & Engn Directorate, RDRL HRS C, Aberdeen Proving Ground, MD 20783 USA.
EM brent.j.lance@us.army.mil; sgordon@dcscorp.com; jean.vettel@us.army.mil;
   tjohnson@dcscorp.com; victor.paul@us.army.mil; cmanteuffel@dcscorp.com;
   mjaswa@dcscorp.com; kelvin.oie@us.army.mil
FU High-Definition Cognition for Operational Environments (HD-Cog) Army
   Technology Objective (ATO)
FX This work was funded under the High-Definition Cognition for Operational
   Environments (HD-Cog) Army Technology Objective (ATO).
NR 15
TC 1
Z9 1
U1 0
U2 3
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24570-1
J9 LECT NOTES COMPUT SC
PY 2011
VL 6975
BP 467
EP +
PN II
PG 3
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
   Methods
SC Computer Science
GA BBD30
UT WOS:000306503700059
ER

PT S
AU Sutthiwan, P
   Shi, YQ
   Zhao, H
   Ng, TT
   Su, W
AF Sutthiwan, Patchara
   Shi, Yun Q.
   Zhao, Hong
   Ng, Tian-Tsong
   Su, Wei
BE Shi, YQ
   Emmanuel, S
   Kankanhalli, MS
   Chang, SF
   Radhakrishnan, R
   Ma, RL
   Zhao, L
TI Markovian Rake Transform for Digital Image Tampering Detection
SO TRANSACTIONS ON DATA HIDING AND MULTIMEDIA SECURITY VI
SE Lecture Notes in Computer Science
LA English
DT Article; Book Chapter
DE Markovian rake transform; color image forgery detection; color image
   tampering detection
ID FORGERIES
AB An effective framework for passive-blind color image tampering detection is presented in this paper. The proposed image statistical features are generated by applying Markovian rake transform to image luminance component. Markovian rake transform is the application of Markov process to difference arrays which are derived from the quantized block discrete cosine transform 2-D arrays with multiple block sizes. The efficacy of thus generated features has been confirmed over a recently established large-scale image dataset designed for tampering detection, with which some relevant issues have been addressed and corresponding adjustment measures have been taken. The initial tests by using thus generated classifiers on some real-life forged images available in the Internet show signs of promise of the proposed features as well as the challenge encountered by the research community of image tampering detection.
C1 [Sutthiwan, Patchara; Shi, Yun Q.] New Jersey Inst Technol, ECE Dept, Newark, NJ 07102 USA.
   [Zhao, Hong] Fairleigh Dickinson Univ, Teaneck, NJ USA.
   [Ng, Tian-Tsong] Inst Infocomm Res, Singapore, Singapore.
   [Su, Wei] USA, CERDEC, Aberdeen Proving Ground, MD USA.
RP Sutthiwan, P (reprint author), New Jersey Inst Technol, ECE Dept, Newark, NJ 07102 USA.
EM ps249@njit.edu; shi@njit.edu; zhao@fdu.edu; ttng@i2r.astar.edu.sg;
   wei.su@us.army.mil; shi@njit.edu
NR 22
TC 7
Z9 7
U1 1
U2 2
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24555-8
J9 LECT NOTES COMPUT SC
PY 2011
VL 6730
BP 1
EP 17
D2 10.1007/978-3-642-24556-5
PG 17
WC Computer Science, Information Systems
SC Computer Science
GA BAE18
UT WOS:000303898500001
ER

PT S
AU Prekas, G
   Sabet, H
   Bhandari, HH
   Derderian, G
   Robertson, F
   Kudrolli, H
   Stapels, CJ
   Christian, J
   Kleinfelder, S
   Cool, S
   Aries, LJD
   Nagarkar, VV
AF Prekas, G.
   Sabet, H.
   Bhandari, H. H.
   Derderian, G.
   Robertson, F.
   Kudrolli, H.
   Stapels, C. J.
   Christian, J.
   Kleinfelder, S.
   Cool, S.
   Aries, L. J. D'
   Nagarkar, V. V.
GP IEEE
TI Direct and Indirect Detectors for X-Ray Photon Counting Systems
SO 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE
   (NSS/MIC)
SE IEEE Nuclear Science Symposium Conference Record
LA English
DT Proceedings Paper
CT IEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th
   International Workshop on Room-Temperature Semiconductor X-Ray and
   Gamma-Ray Detectors
CY OCT 23-29, 2011
CL Valencia, SPAIN
SP IEEE, Inst Elect & Elect Engineers Nucl & Plasma Sci Soc (IEEE NPSS)
ID PIXEL; PHOTODIODE; PET
AB Most currently available X-ray or gamma ray imaging detectors are based on energy integration over a certain period of time. We have been developing X-ray and gamma ray detectors based on the photon counting (with energy determination) concept using both direct and indirect radiation conversion, together with associated application-specific integrated circuits (ASICs). As an alternative to our ASIC design approach, we are also exploiting the potential of state-of-the-art silicon photomultipliers (SiPMs) and discrete electronics. In this paper we discuss the advantages and disadvantages of these two approaches and we report our latest results on our ASIC design efforts and our achievements on SiPMlCsI:Tl detector configurations. We will also discuss the potential uses and advantages that each offers to applications in medicine, imaging, homeland security and industry.
C1 [Prekas, G.; Sabet, H.; Bhandari, H. H.; Derderian, G.; Robertson, F.; Kudrolli, H.; Stapels, C. J.; Christian, J.; Cool, S.; Nagarkar, V. V.] Radiation Monitoring Devices Inc, Watertown, MA 02472 USA.
   [Kleinfelder, S.] Univ Calif Irvine, Henri Samueli Sch Engn, Irvine, CA 92697 USA.
   [Aries, L. J. D'] US Army, ARDEC, Picatinny Arsenal, NJ 07806 USA.
RP Prekas, G (reprint author), Radiation Monitoring Devices Inc, Watertown, MA 02472 USA.
EM VNagarkar@RMDInc.com
FU National Institutes of Health [lR43RR028153-01]; U.S. Department of
   Defense [W15QKN-09-C-0132]
FX This work was supported in part by National Institutes of Health under
   Grant No. lR43RR028153-01 and the U.S. Department of Defense under Grant
   No. W15QKN-09-C-0132.
NR 27
TC 1
Z9 1
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1082-3654
BN 978-1-4673-0120-6
J9 IEEE NUCL SCI CONF R
PY 2011
BP 1487
EP 1493
PG 7
WC Engineering, Electrical & Electronic; Physics, Applied; Imaging Science
   & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Physics; Imaging Science & Photographic Technology;
   Radiology, Nuclear Medicine & Medical Imaging
GA BAM64
UT WOS:000304755601144
ER

PT S
AU Kistenev, E
   Li, Z
   Sukhanov, A
AF Kistenev, E.
   Li, Z.
   Sukhanov, A.
GP IEEE
TI Novel Si sensors and readout for the compact high resolving power
   electromagnetic calorimeter
SO 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE
   (NSS/MIC)
SE IEEE Nuclear Science Symposium Conference Record
LA English
DT Proceedings Paper
CT IEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th
   International Workshop on Room-Temperature Semiconductor X-Ray and
   Gamma-Ray Detectors
CY OCT 23-29, 2011
CL Valencia, SPAIN
SP IEEE, Inst Elect & Elect Engineers Nucl & Plasma Sci Soc (IEEE NPSS)
AB Calorimetry is the most important single tool for electron, photon, and neutral pion measurements and still drives overall detector dimensions and cost. We report here on a development of a new Si detector with "integrated" readout which helps to keep calorimeter dimensions and cost under control simultaneously enhancing the multi-photon resolving power and implementing energy flow measurement capability in Si based calorimeter. The prototype electromagnetic Si-W calorimeter with high resolving power (FOCal) was recently built and tested I with funding provided by PHENIX and is now being upgraded to combine precision position measurements with energy flow measuring functionality (StriPad and MiniPad-structured sensors in every sampling layer). New sensors are made in p+/n/n+ configuration with segmented side being the p+. All devices are read by the 128 channels SVX4 strip readout chip developed at FNAL. Depending on the sensor layout the 128 readout channels are either (I) shared between 16 pixelated pads (15x15 mm(2) each) overlapping with 112 pixelated strips (similar to 0.54x62mm(2) each), or connected to (2) 128 strips (similar to 0.47x62mm(2) each) or (3) 128 minipads (similar to 1.8x15mm(2) each) implemented on a 62x62mm(2) silicon substrate. The sensors are laminated with readout cards which carry one or two (dual gain readout) SVX4 chips to form pluggable micromodules. Thus built micromodules take only 2 mm of longitudinal space in detector leading to dramatic improvement in detector compactness (small Moliere radius). Novel sensors supported by low power, high density fully digital readout allows to upgrade silicon based calorimeter for energy flow measurements at essentially no extra cost.
C1 [Kistenev, E.; Li, Z.; Sukhanov, A.] USA, Brookhaven Natl Lab, Upton, NY 11973 USA.
RP Kistenev, E (reprint author), USA, Brookhaven Natl Lab, Upton, NY 11973 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1082-3654
BN 978-1-4673-0120-6
J9 IEEE NUCL SCI CONF R
PY 2011
BP 1730
EP 1731
PG 2
WC Engineering, Electrical & Electronic; Physics, Applied; Imaging Science
   & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Physics; Imaging Science & Photographic Technology;
   Radiology, Nuclear Medicine & Medical Imaging
GA BAM64
UT WOS:000304755601196
ER

PT S
AU Jones, WF
   Breeding, JE
   Everman, J
   Reed, JH
   Luk, W
   Moor, A
   Casey, ME
AF Jones, W. F.
   Breeding, J. E.
   Everman, J.
   Reed, J. H.
   Luk, W.
   Moor, A.
   Casey, M. E.
GP IEEE
TI Tracking Coincidence Events in PET Even When Count Rates Are Extremely
   High: The Lost-Event Tally Packet Concept
SO 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE
   (NSS/MIC)
SE IEEE Nuclear Science Symposium Conference Record
LA English
DT Proceedings Paper
CT IEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th
   International Workshop on Room-Temperature Semiconductor X-Ray and
   Gamma-Ray Detectors
CY OCT 23-29, 2011
CL Valencia, SPAIN
SP IEEE, Inst Elect & Elect Engineers Nucl & Plasma Sci Soc (IEEE NPSS)
AB We describe techniques which extend the usefulness of real-time data-handling architectures designed for clinical PET - especially for instances of extremely high count rate. As is widely known, Rubidium-82 (82Rb) with a 1.3 minute half-life is often used in clinical PET. When used, 82Rb is more often applied for dynamic and/or gated studies - typically with little or no delay between tracer injection and start of acquisition. The use of 82Rb for short-duration-framed studies in clinical PET has its own set of challenges. Rapid decay means that later frames in a study collect far fewer counts. Increasing the dosage of 82Rb can help increase the counting statistics for short-duration frames. On the other hand, a larger (or too large) dose may temporarily exceed the acquisition throughput. When such saturation occurs, coincidence events are lost. In the case of 82Rb, such loss is typically short lived and limited to the count-rate peak. Such saturation also leads to a truncation of the count-rate profile - a truncation which often limits curve fitting essential for an accurate compartmental model across the entire study. The clinician may simply reduce the 82Rb dosage to avoid such saturation. But this reduction also limits the counts available in later frames - as stated. The techniques offered here help revolve this dilemma. By electronically keeping track of those events which are subject to saturation loss, the complete count-rate profile itself is preserved. Such tracking is done in real time with an accurate log of loss quantities added to the list-mode stream. This approach enables the clinician to raise the 82Rb dose without a specific concern over count-rate profile truncation. We describe a special 64-bit non-event (i.e. "tag") packet which is automatically inserted into the list-mode stream. The "Lost-Event Tally" tag packet stream enables a full recovery of the rate profile even when event packets are lost. During acquisition, this tag packet is repeatedly inserted into the stream to report the counted event-packet loss (up to 1048575) since the previous such tag packet was inserted.
C1 [Jones, W. F.; Breeding, J. E.; Everman, J.; Reed, J. H.; Luk, W.; Moor, A.; Casey, M. E.] USA, Siemens Med Solut, Knoxville, TN 37932 USA.
RP Jones, WF (reprint author), USA, Siemens Med Solut, Knoxville, TN 37932 USA.
EM william.f.jones@siemens.com; john.breeding@siemens.com;
   jimmy.everman@siemens.com; johnny.reed@siemens.com;
   wing.luk@siemens.com; andrew.moor@siemens.com;
   michael.e.casey@siemens.com
NR 6
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1082-3654
BN 978-1-4673-0120-6
J9 IEEE NUCL SCI CONF R
PY 2011
BP 3227
EP 3231
PG 5
WC Engineering, Electrical & Electronic; Physics, Applied; Imaging Science
   & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Physics; Imaging Science & Photographic Technology;
   Radiology, Nuclear Medicine & Medical Imaging
GA BAM64
UT WOS:000304755603102
ER

PT S
AU Bickley, AA
   Demaree, GK
   McClory, JW
   Miller, WH
   Oakes, TM
   Petrosky, JC
AF Bickley, Abigail A.
   Demaree, Grant K.
   McClory, John W.
   Miller, William H.
   Oakes, Thomas M.
   Petrosky, James C.
GP IEEE
TI Design Optimization of a Layered Boron Based Solid State Neutron
   Spectrometer
SO 2011 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE
   (NSS/MIC)
SE IEEE Nuclear Science Symposium Conference Record
LA English
DT Proceedings Paper
CT IEEE Nuclear Science Symposium/Medical Imaging Conference (NSS/MIC)/18th
   International Workshop on Room-Temperature Semiconductor X-Ray and
   Gamma-Ray Detectors
CY OCT 23-29, 2011
CL Valencia, SPAIN
SP IEEE, Inst Elect & Elect Engineers Nucl & Plasma Sci Soc (IEEE NPSS)
AB The high thermal neutron capture cross section of boron provides a unique opportunity for the construction of solid state neutron detectors with application to the identification of nuclear fuels and non-proliferation activities. The ionization resulting from the neutron capture products, B-10+n -> Li-7+alpha, is deposited within a short range of the initial interaction, thus allowing the location of the capture event to be determined. Construction of a system consisting of alternating layers of thin sensitive detector and moderating materials in a geometrically regular shape that allows coordinate dependence of neutron thermalization to be determined results in a novel solid state neutron spectrometer. A GEANT4 model has been developed to study neutron thermalization as a function of detector geometry, neutron moderation materials, and radial sensitivity. The simulation results indicate that a unique relationship exists between the incident neutron energy and the statistical pattern of energy deposition. This allows the geometrical configuration and moderator identity to be tuned to match the neutron energy spectrum of interest. The detector response is found empirically to match the shape of the Fisher statistic distribution allowing the incident neutron spectrum to be extracted without unfolding. Furthermore, the pattern of energy deposition is strongly dependent on the direction of incidence of the neutrons. Ultimately, this instrument can be used to spectroscopically differentiate localized neutron sources from a cosmic background.
C1 [Bickley, Abigail A.; McClory, John W.; Petrosky, James C.] USAF, Inst Technol, Dept Engn Phys, Wright Patterson AFB, OH 45433 USA.
   [Demaree, Grant K.] US Mil Acad, West Point, NY 10996 USA.
   [Miller, William H.; Oakes, Thomas M.] Univ Missouri, NUclear Sci & Engn Inst, Columbia, MO 65212 USA.
RP Bickley, AA (reprint author), USAF, Inst Technol, Dept Engn Phys, Wright Patterson AFB, OH 45433 USA.
EM abigail.bickley@afit.edu; grant.demaree@usma.edu; john.mcclory@afit.edu;
   millerw@missouri.edu; tmo6w3@mail.missouri.edu; james.petrosky@afit.edu
NR 5
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1082-3654
BN 978-1-4673-0120-6
J9 IEEE NUCL SCI CONF R
PY 2011
BP 4872
EP 4876
PG 5
WC Engineering, Electrical & Electronic; Physics, Applied; Imaging Science
   & Photographic Technology; Radiology, Nuclear Medicine & Medical Imaging
SC Engineering; Physics; Imaging Science & Photographic Technology;
   Radiology, Nuclear Medicine & Medical Imaging
GA BAM64
UT WOS:000304755605021
ER

PT S
AU Goldberg, BS
   Sottilare, RA
   Brawner, KW
   Holden, HK
AF Goldberg, Benjamin S.
   Sottilare, Robert A.
   Brawner, Keith W.
   Holden, Heather K.
BE DMello, S
   Graesser, A
   Schuller, B
   Martin, JC
TI Predicting Learner Engagement during Well-Defined and Ill-Defined
   Computer-Based Intercultural Interactions
SO AFFECTIVE COMPUTING AND INTELLIGENT INTERACTION, PT I
SE Lecture Notes in Computer Science
LA English
DT Proceedings Paper
CT 4th Bi-Annual International Conference of the Humaine Association on
   Affective Computing and Intelligent Interaction (ACII 2011)
CY OCT 09-12, 2011
CL Memphis, TN
SP Univ Memphis, HUMAINE Assoc, FedEx Inst Techn, Inst Intelligent Syst, Aldebaran Robot
DE learner engagement; well-defined tasks; ill-defined tasks; EEG
AB This article reviews the first of two experiments investigating the effect tailoring of training content has on a learner's perceived engagement, and to examine the influence the Big Five Personality Test and the Self-Assessment Manikin (SAM) mood dimensions have on these outcome measures. A secondary objective is to then correlate signals from physiological sensors and other variables of interest, and to develop a model of learner engagement. Self-reported measures were derived from the engagement index of the Independent Television Commission-Sense of Presence Inventory (ITC-SOPI). Physiological measures were based on the commercial Emotiv Epoc Electroencephalograph (EEG) brain-computer interface. Analysis shows personality factors to be reliable predictors of general engagement within well-defined and ill-defined tasks, and could be used to tailor instructional strategies where engagement was predicted to be non-optimal. It was also evident that Emotiv provides reliable measures of engagement and excitement in near real-time.
C1 [Goldberg, Benjamin S.; Sottilare, Robert A.; Brawner, Keith W.; Holden, Heather K.] USA, Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr, Orlando, FL 32826 USA.
RP Goldberg, BS (reprint author), USA, Res Lab, Human Res & Engn Directorate, Simulat & Training Technol Ctr, Orlando, FL 32826 USA.
EM benjamin.s.goldberg@us.army.mil; robert.sottilare@us.army.mil;
   keith.w.brawner@us.army.mil; heather.k.holden@us.army.mil
OI Sottilare, Robert/0000-0002-5278-2441
NR 20
TC 4
Z9 4
U1 0
U2 7
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0302-9743
BN 978-3-642-24599-2
J9 LECT NOTES COMPUT SC
PY 2011
VL 6974
BP 538
EP 547
PN I
PG 10
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
   Methods
SC Computer Science
GA BBD28
UT WOS:000306503500057
ER

PT J
AU Pamplin, JC
   Murray, SJ
   Chung, KK
AF Pamplin, Jeremy C.
   Murray, Sarah J.
   Chung, Kevin K.
TI Phases-of-illness paradigm: better communication, better outcomes
SO CRITICAL CARE
LA English
DT Article
ID INTENSIVE-CARE-UNIT; SAFETY
AB Communication failures are a significant contributor to medical errors that harm patients. Critical care delivery is a complex system of inter-professional work that is distributed across time, space, and multiple disciplines. Because health-care education and delivery remain siloed by profession, we lack a shared framework within which we discuss and subsequently optimize patient care. Furthermore, our disparate professional perspectives and interests often interfere with our ability to effectively prioritize individual care. It is important, therefore, to develop a cognitively shared framework for understanding a patient's severity of illness and plan of care across multiple, traditionally poorly communicating disciplines. We suggest that the 'phases-of-illness paradigm' will facilitate communication about critically ill patients and create a shared mental model for interdisciplinary patient care. In so doing, this paradigm may reduce communication errors, complications, and costs while improving resource utilization and trainee education. Additional research applications are feasible.
C1 [Pamplin, Jeremy C.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
   [Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Pamplin, JC (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM jeremy.pamplin@us.army.mil
NR 15
TC 2
Z9 2
U1 2
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1466-609X
J9 CRIT CARE
JI Crit. Care
PY 2011
VL 15
IS 6
AR 309
DI 10.1186/cc10335
PG 7
WC Critical Care Medicine
SC General & Internal Medicine
GA 969VJ
UT WOS:000306087200011
PM 22188663
ER

PT J
AU Iida, J
   Clancy, RL
   Lehman, JR
   Somiari, S
   Somiari, R
   Mural, RJ
   Shriver, CD
AF Iida, J.
   Clancy, R. L.
   Lehman, J. R.
   Somiari, S.
   Somiari, R.
   Mural, R. J.
   Shriver, C. D.
TI Development of DNA aptamers to CD44 that inhibit migration of breast
   cancer cells.
SO MOLECULAR BIOLOGY OF THE CELL
LA English
DT Meeting Abstract
CT Annual Meeting of the American-Society-for-Cell-Biology (ASCB)
CY DEC 03-07, 2011
CL Denver, CO
SP Amer Soc Cell Biol (ASCB)
C1 [Somiari, S.] Windber Res Inst, Tissue Bank, Windber, PA USA.
   [Somiari, R.] ITSI BioSci, Johnstown, PA USA.
   [Shriver, C. D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER SOC CELL BIOLOGY
PI BETHESDA
PA 8120 WOODMONT AVE, STE 750, BETHESDA, MD 20814-2755 USA
SN 1059-1524
J9 MOL BIOL CELL
JI Mol. Biol. Cell
PY 2011
VL 22
MA 1361
PG 2
WC Cell Biology
SC Cell Biology
GA 961YM
UT WOS:000305505502474
ER

PT J
AU Weichel, ED
   Eiseman, AS
   Casler, JD
   Bartley, GB
AF Weichel, Eric D.
   Eiseman, Andrew S.
   Casler, John D.
   Bartley, George B.
TI Rectus Abdominus Free Flap in the Reconstruction of the Orbit Following
   Subtotal Exenteration
SO OPHTHALMIC SURGERY LASERS & IMAGING
LA English
DT Article
ID INTERGROUP RHABDOMYOSARCOMA
AB An 18-year-old woman with recurrent embryonal rhabdomyosarcoma underwent a right subtotal exenteration sparing the eyelids and conjunctiva to remove the tumor. A rectus abdominus muscle free flap was secured to the right temporalis muscle. The temporalis muscle was then advanced into the temporal fossa defect and the rectus abdominus flap placed into the right orbital cavity and right maxillary sinus. An ocular conformer was then placed and a lateral tarsorrhaphy was performed. This surgical technique provides rapid socket rehabilitation with good cosmesis and enables the use of a standard ocular prosthesis. [Ophthalmic Surg Lasers Imaging 2011;42:83-86.]
C1 [Eiseman, Andrew S.] Walter Reed Army Med Ctr, Ophthalmol Serv, Dept Ophthalmol, Washington, DC 20307 USA.
   [Bartley, George B.] Mayo Clin, Dept Ophthalmol, Rochester, MN USA.
   [Casler, John D.] Mayo Clin, Dept Ophthalmol, Jacksonville, FL 32224 USA.
RP Eiseman, AS (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, Dept Ophthalmol, 6900 Georgia Ave, Washington, DC 20307 USA.
NR 7
TC 2
Z9 2
U1 0
U2 0
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1542-8877
J9 OPHTHAL SURG LAS IM
JI Ophthalmic Surg. Lasers Imaging
PD JAN-FEB
PY 2011
VL 42
IS 1
BP 83
EP 86
DI 10.3928/15428877-20110120-03
PG 4
WC Ophthalmology; Surgery
SC Ophthalmology; Surgery
GA 959PQ
UT WOS:000305325700014
PM 21229957
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI UNFINISHED BUSINESS An American Strategy for Iraq Moving Forward
   INTRODUCTION
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Editorial Material; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP 1
EP 10
PG 10
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800002
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI UNFINISHED BUSINESS An American Strategy for Iraq Moving Forward Preface
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Editorial Material; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP VII
EP +
PG 7
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800001
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI GOALS AND INFLUENCE
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Article; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP 11
EP 34
PG 24
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800003
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI POLITICS
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Article; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 1
Z9 1
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP 35
EP 60
PG 26
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800004
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI SECURITY
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Article; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP 61
EP 86
PG 26
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800005
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI GOVERNANCE AND ECONOMICS
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Article; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP 87
EP 104
PG 18
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800006
ER

PT J
AU Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
AF Pollack, Kenneth M.
   Alkadiri, Raad
   Carpenter, J. Scott
   Kagan, Frederick W.
   Kane, Sean
BA Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
BF Pollack, KM
   Alkadiri, R
   Carpenter, JS
   Kagan, FW
   Kane, S
TI REGIONAL ISSUES
SO UNFINISHED BUSINESS: AN AMERICAN STRATEGY FOR IRAQ MOVING FORWARD
LA English
DT Article; Book Chapter
C1 [Carpenter, J. Scott] Washington Inst Near E Policy, Washington, DC USA.
   [Carpenter, J. Scott] Coalit Provis Author, Governance Grp, Baghdad, Iraq.
   [Kagan, Frederick W.] US Mil Acad, West Point, NY USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU BROOKINGS INST
PI WASHINGTON
PA 1775 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
BN 978-0-81572-166-6
PY 2011
BP 105
EP 113
PG 9
WC International Relations; Political Science
SC International Relations; Government & Law
GA BZK56
UT WOS:000301850800007
ER

PT B
AU McNeal, G
AF McNeal, Greg
BE McIntyre, DH
   Hancock, WI
TI The legal impact of homeland security on business
SO BUSINESS CONTINUITY AND HOMELAND SECURITY, VOL 1: THE CHALLENGE OF THE
   NEW AGE
LA English
DT Article; Book Chapter
C1 [McNeal, Greg] Terrorism & Homeland Secur, Santa Monica, CA 90407 USA.
   [McNeal, Greg] Case Western Reserve Univ, Sch Law, Inst Global Secur Law & Policy, Cleveland, OH 44106 USA.
   [McNeal, Greg] American Univ, Sch Publ Affairs, Washington, DC 20016 USA.
   [McNeal, Greg] USA, Washington, DC USA.
RP McNeal, G (reprint author), Terrorism & Homeland Secur, Santa Monica, CA 90407 USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU EDWARD ELGAR PUBLISHING LTD
PI CHELTENHAM
PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND
BN 978-1-84720-250-5
PY 2011
BP 28
EP 37
PG 10
WC Business; Economics
SC Business & Economics
GA BYJ45
UT WOS:000299042100007
ER

PT B
AU Sherstyuk, A
   Vincent, D
   Berg, B
   Treskunov, A
AF Sherstyuk, Andrei
   Vincent, Dale
   Berg, Benjamin
   Treskunov, Anton
BE Furht, B
TI Mixed Reality Manikins for Medical Education
SO HANDBOOK OF AUGMENTED REALITY
LA English
DT Article; Book Chapter
ID TACTILE AUGMENTATION
AB In medical education, human patient simulators, or manikins, are a well established method of teaching medical skills. The current state of the art manikins are limited in their functions by a fixed number of in-built hardware devices, such as pressure sensors and motor actuators that control the manikin behaviors and responses.
   In this work, we review several research projects, where applied techniques from the fields of Augmented and Mixed Reality allowed to significantly expand manikin functionality. We will pay special attention to tactile augmentation, and describe in detail a fully functional "touch-enabled" human manikin, developed at SimTiki Medical Simulation Center, University of Hawaii. Also, we will outline possible extensions of the proposed touch-augmented human patient simulator and share our thoughts on the future directions in use of Augmented Reality in medical education.
C1 [Sherstyuk, Andrei] Avatar Real Inc, Honolulu, HI USA.
   [Berg, Benjamin] Univ Hawaii, SimTiki Simulat Ctr, Honolulu, HI 96822 USA.
   [Treskunov, Anton] Samsung Informat Syst Amer Inc SISA, San Jose, CA USA.
   [Vincent, Dale] Tripler Army Med Ctr, Internal Med Program, Honolulu, HI 96859 USA.
RP Sherstyuk, A (reprint author), Avatar Real Inc, Honolulu, HI USA.
EM andrei@avatar-reality.com; dale.vincent@amedd.army.mil;
   bwberg@hawaii.edu; anton.t@sisa.samsung.com
NR 24
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
BN 978-1-4614-0063-9
PY 2011
BP 479
EP 500
DI 10.1007/978-1-4614-0064-6_23
D2 10.1007/978-1-4614-0064-6
PG 22
WC Computer Science, Cybernetics; Imaging Science & Photographic Technology
SC Computer Science; Imaging Science & Photographic Technology
GA BYW48
UT WOS:000300642100023
ER

PT J
AU Ahroon, WA
   Hill, ME
   Goodes, DP
AF Ahroon, William A.
   Hill, Melinda E.
   Goodes, Dennis P.
TI Analysis of army-wide hearing conservation database for hearing profiles
   related to crew-served and individual weapon systems
SO NOISE & HEALTH
LA English
DT Article
DE Hearing loss; impulse; military occupational specialty; MOS; noise
ID IMPULSE NOISE
AB Damage-risk criteria (DRC) for noise exposures are designed to protect 95 of the exposed populations from hearing injuries caused by those noise exposures. The current DRC used by the US military follows OSHA guidelines for continuous noise. The current military DRC for impulse exposures follows the recommendations from the National Academy of Sciences - National Research Council Committee on Hearing, Bioacoustics, and Biomechanics (CHABA) and are contained in the current military standard, MIL-STD-1474D "Noise Limits." Suggesting that the MIL-STD for impulse exposure is too stringent, various individuals have proposed that the DRC for exposure to high-level impulses be relaxed. The purpose of this study is to evaluate the current hearing status of US Army Soldiers, some of whom can be, by their military occupational specialties (MOS), reasonably expected to be routinely exposed to high-level impulses from weapon systems. The Defense Occupational and Environmental Health Readiness System - Hearing Conservation (DOEHRS-HC) was queried for the hearing status of enlisted Soldiers of 32 different MOSs. The results indicated that less than 95 of the Soldiers in the DOEHRS-HC database were classified as having normal hearing. In other words, the goal of the DRC used for limiting noise injuries (from continuous and impulse exposures) was not stringent enough to prevent hearing injuries in all but the most susceptible Soldiers. These results suggest that the current military noise DRC should not be relaxed.
C1 [Ahroon, William A.; Hill, Melinda E.] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA.
   [Goodes, Dennis P.] Gen Dynam Informat Technol, Ft Detrick, MD 21702 USA.
RP Ahroon, WA (reprint author), USA, Aeromed Res Lab, 6901 Farrel Rd, Ft Rucker, AL 36362 USA.
EM william.ahroon@us.army.mil
NR 24
TC 2
Z9 2
U1 1
U2 11
PU MEDKNOW PUBLICATIONS
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 1463-1741
J9 NOISE HEALTH
JI Noise Health
PD JAN-FEB
PY 2011
VL 13
IS 50
BP 76
EP 83
DI 10.4103/1463-1741.73992
PG 8
WC Audiology & Speech-Language Pathology; Public, Environmental &
   Occupational Health
SC Audiology & Speech-Language Pathology; Public, Environmental &
   Occupational Health
GA 950SW
UT WOS:000304670300012
PM 21173491
ER

PT S
AU Deal, B
   Jenicek, E
   Goran, W
   Myers, N
   Fittipaldi, J
AF Deal, B.
   Jenicek, E.
   Goran, W.
   Myers, N.
   Fittipaldi, J.
BE Sinha, AK
   Arctur, D
   Jackson, I
   Gundersen, LC
TI Strategic Sustainability Assessment
SO SOCIETAL CHALLENGES AND GEOINFORMATICS
SE Geological Society of America Special Papers
LA English
DT Article; Book Chapter
ID SIMULATION; NITROGEN
AB New strategies for sustainability within the Department of Defense are focused on addressing present and future needs while strengthening community partnerships that improve operational abilities. This "across-the-fence line" strategic thinking requires innovative tools that can engage a broad segment of the community and a variety of military interest groups. These tools must provide a platform for understanding the challenges and realizing the goals of both private-and public-sector interests. They must tangibly represent many different potential futures, their implications, and policies that can help mobilize solutions quickly and easily in a uniform, consistent, and democratic manner. The Strategic Sustainability Assessment (SSA) consists of a series of complementary tools for forecasting and backcasting that provide regional stakeholders a unique perspective on potential sustainable regional policy and investment choices. Forecasting approaches use dynamic spatial modeling techniques to project potential future urban transformations and their implication to the social, environmental, and economic fabric of the region. Backcasting is used to determine critical sets of strategic interventions designed to offset the simulated future impacts. The results of the analysis are managed through the use of a Web-based GeoPortal. This helps to democratize the information by providing it to local stakeholders in a useable and accessible way. The hope is that greater and more direct access to models and the information they generate will help lead to better, more sustainable planning decisions in our military bases and in our communities.
C1 [Deal, B.] Univ Illinois, Dept Urban & Reg Planning, Champaign, IL 61820 USA.
   [Jenicek, E.; Goran, W.; Myers, N.] Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.
   [Fittipaldi, J.] USA, Environm Policy Inst, Arlington, VA 22202 USA.
RP Deal, B (reprint author), Univ Illinois, Dept Urban & Reg Planning, Champaign, IL 61820 USA.
NR 25
TC 1
Z9 1
U1 0
U2 3
PU GEOLOGICAL SOC AMER INC
PI BOULDER
PA 3300 PENROSE PL, PO BOX 9140, BOULDER, CO 80301 USA
SN 0072-1077
BN 978-0-8137-2482-9
J9 GEOL SOC AM SPEC PAP
PY 2011
VL 482
BP 41
EP 57
DI 10.1130/2011.2482(05)
D2 10.1130/9780813724829
PG 17
WC Geology
SC Geology
GA BYW18
UT WOS:000300632500006
ER

PT J
AU Kim, CS
   Lim, HS
   Cerco, CF
AF Kim, C. S.
   Lim, H. S.
   Cerco, C. F.
TI Three-Dimensional Water Quality Modelling for Tidal Lake and Coastal
   Waters with ROMS-ICM
SO JOURNAL OF COASTAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 11th International Coastal Symposium (ICS)
CY MAY 09-13, 2011
CL Szczecin, POLAND
SP Univ Szczecin, Inst Marine & Coastal Sci, Coastal Educ & Res Fdn, Univ Szczecinski (US), Cztowiek Nauka Srodowisko (CNS), ZMGM, Reg Dyrekcja Ochrony Srodowiska, Esri, Springer, Lotos, GA2 Syst, World Sci, Helmholtz-Zentrum Geesthacht, Nfosigm, Urzad Marszalkowski Wojewodztwa Zachodniopomorskiego, Wojewodzki Fundusz Ochrony Srodowiska I Gospodarki Wodnej W Gdansku
DE Sea dyke; Model coupling; Eutrophication; Nutrient; Hydrodynamics
ID KYUNGGI BAY; KOREA
AB We have developed a three-dimensional water quality model (ROMS-ICM) that consists of hydrodynamic model of ROMS and eutrophication model of CE-QUAL-ICM. The ROMS in structured grid has been linked with the unstructured CE-QUAL-ICM model by using the new linkage codes. To have more flexibility on computational resource and efficiency, the coupling of ROMS-ICM has been developed for the external linkage. The ROMS-ICM has been tested for the seasonal variation of state variables by applying to the Saemangeum tidal lake and coastal waters of Korea. The model performance has been calibrated with observed field data of water quality parameters such as temperature, salinity, chlorophyll, dissolved oxygen, phosphorus, and nitrogen. The data have been collected at more than 15 points in the tidal lake and coastal waters at every month in 2009. Major loadings of nutrients from river flows and controlling points at sea water gates of the tidal lake allow us to estimate the annual cycle of state variables. A process-based validation has been conducted by comparing the salinity budget estimated by using the ROMS alone and the ROMS-ICM. The calibration and validation results show a promising tool for understanding of existing condition and for predicting the future condition of the water quality in Saemangeum tidal lake and coastal waters.
C1 [Kim, C. S.; Lim, H. S.] Korea Ocean R&D Inst, Saemangeum Coastal Res Ctr, Ansan 426744, South Korea.
   [Cerco, C. F.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39108 USA.
RP Kim, CS (reprint author), Korea Ocean R&D Inst, Saemangeum Coastal Res Ctr, Ansan 426744, South Korea.
EM surfkim@kordi.re.kr; carl.f.cerco@usace.army.mil
FU Ministry of Land, Transport and Maritime Affairs, Korea
FX This research was a part of the project entitled "Saemangeum coastal
   system research for marine environment conservation" and "Development of
   Korea Operational Oceanographic System (KOOS)" funded by Ministry of
   Land, Transport and Maritime Affairs, Korea. Partial support by In-House
   Innovative Program and the project on functional improvement of Korea
   Ocean Satellite Center are greatly appreciated. The authors thank to the
   US Army Corps of Engineers (USAE ERDC) for the cooperative partnership
   with KORDI.
NR 9
TC 6
Z9 6
U1 1
U2 6
PU COASTAL EDUCATION & RESEARCH FOUNDATION
PI LAWRENCE
PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA
SN 0749-0208
EI 1551-5036
J9 J COASTAL RES
JI J. Coast. Res.
PY 2011
SI 64
BP 1068
EP 1072
PN 2
PG 5
WC Environmental Sciences; Geography, Physical; Geosciences,
   Multidisciplinary
SC Environmental Sciences & Ecology; Physical Geography; Geology
GA 926IR
UT WOS:000302825000007
ER

PT S
AU Sablon, KA
   Little, JW
   Mitin, V
   Sergeev, A
   Vagidov, N
   Reinhardt, K
AF Sablon, K. A.
   Little, J. W.
   Mitin, V.
   Sergeev, A.
   Vagidov, N.
   Reinhardt, K.
BE Tsakalakos, L
TI HIGH EFFICIENCY QUANTUM DOT SOLAR CELLS DUE TO INTER-DOT N-DOPING
SO NEXT GENERATION (NANO) PHOTONIC AND CELL TECHNOLOGIES FOR SOLAR ENERGY
   CONVERSION II
SE Proceedings of SPIE
LA English
DT Proceedings Paper
CT Conference on Next Generation (Nano) Photonic and Cell Technologies for
   Solar Energy Conversion II
CY AUG 21-23, 2011
CL San Diego, CA
SP SPIE
DE Quantum dots; solar cells; potential barrier; dot population; IR energy;
   harvesting
ID PHOTODETECTOR; ENHANCEMENT
AB We investigated the effects of doping on the photovoltaic efficiency in a GaAs reference cell, and in undoped, n-doped, and p-doped InAs/GaAs quantum-dot (QD) solar cells. We found that the photovoltaic efficiency of the undoped QD solar cell is almost the same as that of the reference cell. However, the efficiency improves monotonically with increasing inter-dot n-doping, while p-doping deteriorates the photovoltaic conversion. We observed a 50 % increase in photovoltaic efficiency in the device n-doped to provide approximately six electrons per dot as compared with the undoped QD cell. In this QD solar cell, the short circuit current density increases to 24.30 mA/cm(2) compared with 15.07 mA/cm(2) in the undoped QD solar cell without deterioration of the open circuit voltage. To identify the physical mechanisms that provide this improvement, we investigated the spectral characteristics of the photovoltaic response and photoluminescence of our QD solar cells. We found that the electron capture into QDs is substantially faster than the hole capture, which leads to an accumulation of electrons in QDs. The electrons trapped in dots enhance IR transitions. The built-in-dot electron charge together with charged dopants outside the dots creates potential barriers, which suppress the fast electron capture processes and at the larger scale form a potential profile which precludes degradation of the open circuit voltage. All of these factors lead to the enhanced harvesting of IR energy and a radical improvement of the QD solar cell efficiency. Higher efficiencies are anticipated with further increase of doping level and at higher radiation intensity. This makes the QD solar cells promising candidates for use with concentrators of solar radiation.
C1 [Sablon, K. A.; Little, J. W.] USA, Res Lab, Adelphi, MD 20783 USA.
RP Sablon, KA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
NR 20
TC 0
Z9 0
U1 1
U2 6
PU SPIE-INT SOC OPTICAL ENGINEERING
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
SN 0277-786X
BN 978-0-8194-8721-6
J9 PROC SPIE
PY 2011
VL 8111
AR 81110H
DI 10.1117/12.894618
PG 10
WC Energy & Fuels; Nanoscience & Nanotechnology; Optics
SC Energy & Fuels; Science & Technology - Other Topics; Optics
GA BAC53
UT WOS:000303797800008
ER

PT S
AU Gillich, D
   Shannon, M
   Kovanen, A
   Anderson, T
   Bright, K
   Edwards, R
   Danon, Y
   Moretti, B
   Musk, J
AF Gillich, Don
   Shannon, Mike
   Kovanen, Andrew
   Anderson, Tom
   Bright, Kevin
   Edwards, Ronald
   Danon, Yaron
   Moretti, Brian
   Musk, Jeffrey
BE McDaniel, FD
   Doyle, BL
TI Pyroelectric Crystal Accelerator In The Department Of Physics And
   Nuclear Engineering At West Point
SO APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: TWENTY-FIRST
   INTERNATIONAL CONFERENCE
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 21st International Conference on Application of Accelerators in Research
   and Industry (CAARI)
CY AUG 08-13, 2010
CL Ft Worth, TX
SP Univ N Texas, Sandia Natl Labs, Los Alamos Natl Lab, AccSys Technol Inc, High Voltage Engn Europa BV, Natl Electrostat Corp, TDK-Lambda Amer
DE Pyroelectric Crystal Accelerator; Educational Accelerator; Nuclear
   Fusion; Neutrons
AB The Nuclear Science and Engineering Research Center (NSERC), a Defense Threat Reduction Agency (DTRA) office located at the United States Military Academy (USMA), sponsors and manages cadet and faculty research in support of DTRA objectives. The NSERC has created an experimental pyroelectric crystal accelerator program to enhance undergraduate education at USMA in the Department of Physics and Nuclear Engineering. This program provides cadets with hands-on experience in designing their own experiments using an inexpensive tabletop accelerator. This device uses pyroelectric crystals to ionize and accelerate gas ions to energies of similar to 100 keV. Within the next year, cadets and faculty at USMA will use this device to create neutrons through the deuterium-deuterium (D-D) fusion process, effectively creating a compact, portable neutron generator. The double crystal pyroelectric accelerator will also be used by students to investigate neutron, x-ray, and ion spectroscopy.
C1 [Gillich, Don; Kovanen, Andrew; Anderson, Tom; Bright, Kevin; Edwards, Ronald; Moretti, Brian] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
   [Shannon, Mike; Musk, Jeffrey] Def Threat Reduct Agcy, Nucl Sci & Engn Res Ctr, West Point, NY 10996 USA.
   [Danon, Yaron] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA.
RP Gillich, D (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
NR 6
TC 0
Z9 0
U1 0
U2 6
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0891-3
J9 AIP CONF PROC
PY 2011
VL 1336
BP 763
EP 766
DI 10.1063/1.3586206
PG 4
WC Physics, Applied
SC Physics
GA BZT55
UT WOS:000302912900160
ER

PT S
AU Anderson, T
   Edwards, R
   Bright, K
   Kovanen, A
   Danon, Y
   Moretti, B
   Musk, J
   Shannon, M
   Gillich, D
AF Anderson, Tom
   Edwards, Ronald
   Bright, Kevin
   Kovanen, Andrew
   Danon, Yaron
   Moretti, Brian
   Musk, Jeffrey
   Shannon, Mike
   Gillich, Don
BE McDaniel, FD
   Doyle, BL
TI Preliminary Results from Pyroelectric Crystal Accelerator
SO APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: TWENTY-FIRST
   INTERNATIONAL CONFERENCE
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 21st International Conference on Application of Accelerators in Research
   and Industry (CAARI)
CY AUG 08-13, 2010
CL Ft Worth, TX
SP Univ N Texas, Sandia Natl Lab, Los Alamos Natl Labs, AccSys Technol Inc, High Voltage Engn Europa BV, Natl Electrostat Corp, TDK-Lambda Amer
DE Pyroelectric Crystal Accelerator; Educational Accelerator; Nuclear
   Fusion; Neutrons
AB The Nuclear Science and Engineering Research Center (NSERC), a Defense Threat Reduction Agency (DTRA) office located at the United States Military Academy (USMA), sponsors and manages cadet and faculty research in support of DTRA objectives. Cadets in the Department of Physics and Nuclear Engineering at USMA are using pyroelectric crystals to ionize and accelerate residual gas trapped inside a vacuum system. A system using two lithium tantalate crystals with associated diagnostics was designed and is now operational. X-ray energies of approximately 150 keV have been achieved. Future work will focus on developing a portable neutron generator using the D-D nuclear fusion process.
C1 [Anderson, Tom; Edwards, Ronald; Bright, Kevin; Kovanen, Andrew; Moretti, Brian; Gillich, Don] US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
RP Anderson, T (reprint author), US Mil Acad, Dept Phys & Nucl Engn, West Point, NY 10996 USA.
NR 5
TC 0
Z9 0
U1 0
U2 6
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0891-3
J9 AIP CONF PROC
PY 2011
VL 1336
BP 767
EP 769
DI 10.1063/1.3586207
PG 3
WC Physics, Applied
SC Physics
GA BZT55
UT WOS:000302912900161
ER

PT S
AU Mitin, V
   Sergeev, A
   Vagidov, N
   Sablon, KA
   Little, JW
AF Mitin, V.
   Sergeev, A.
   Vagidov, N.
   Sablon, K. A.
   Little, J. W.
BE Khodaparast, GA
   Santos, MB
   Stanton, CJ
TI Quantum Dot IR Photodetectors and Solar Cells Enhanced by Built-in
   Charge
SO 15TH INTERNATIONAL CONFERENCE ON NARROW GAP SYSTEMS (NGS15)
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 15th International Conference on Narrow Gap Systems (NGS)
CY AUG 01-05, 2011
CL Campus Virginia Tech, Blacksburg, VA
SP Virginia Tech, Bradley Dept Elect & Comp Engn, Dept Phys, Virginia Tech, Advance VT, Coll Sci, Dept Mat Sci & Engn, Virginia Tech, Off Vice President Res, Virginia Tech, Inst Crit Technol & Appl Sci (ICTAS), Univ Oklahoma, Coll Engn, BAE Syst, Coherent Inc, Oxford Instruments, Janis Res, Wiley, Cryo Industries, Nikon Instruments, STAIB Instruments, Pearson Educ, Amer Elements
HO Campus Virginia Tech
DE Quantum dots; built-in charge; solar cells; infrared detectors; capture
   processes
AB Electron transitions in the IR range, which correspond to transitions in the narrow bandgap semiconductors, are also realized in quantum-dot structures. Quantum-dot optoelectronic devices, which can replace devices based on narrow bandgap semiconductors, provide more flexibility for nanoscale engineering of photoelectron kinetics as well as improving coupling to IR radiation. Here, we report on radical improvement of quantum-dot solar cells and quantum-dot infrared photodetectors provided by Quantum dots with Built-In Charge (Q-BIC). We observed a 50% increase in the photovoltaic efficiency of n-doped Q-BIC solar cells with similar to 6 electrons per dot. In this cell, the short circuit current density increases up to 24.30 mA/cm(2), compared with 15.07 mA/cm(2) in an undoped cell, without deterioration of the open circuit voltage. We also observed similar to 25 times increase of the photoresponse of Q-BIC IR photodetector when the built-in charge increases from 1 electron to 6 electrons per dot.
C1 [Mitin, V.; Sergeev, A.; Vagidov, N.] SUNY Buffalo, 332 Bonner Hall, Buffalo, NY 14260 USA.
   [Sablon, K. A.; Little, J. W.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Mitin, V (reprint author), SUNY Buffalo, 332 Bonner Hall, Buffalo, NY 14260 USA.
FU ARL Extreme Energy
FX This work was partially supported by ARL Extreme Energy Grant
NR 2
TC 0
Z9 0
U1 0
U2 2
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0993-4
J9 AIP CONF PROC
PY 2011
VL 1416
BP 52
EP 55
DI 10.1063/1.3671696
PG 4
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA BZC63
UT WOS:000301110800012
ER

PT S
AU Sarney, WL
   Svensson, SP
   Hier, H
   Donetsky, D
   Wang, D
   Shterengas, L
   Suchalkin, S
   Belenky, G
AF Sarney, W. L.
   Svensson, S. P.
   Hier, H.
   Donetsky, D.
   Wang, D.
   Shterengas, L.
   Suchalkin, S.
   Belenky, G.
BE Khodaparast, GA
   Santos, MB
   Stanton, CJ
TI New Approaches to Direct Bandgap III-V Materials for LWIR Detector
   Applications
SO 15TH INTERNATIONAL CONFERENCE ON NARROW GAP SYSTEMS (NGS15)
SE AIP Conference Proceedings
LA English
DT Proceedings Paper
CT 15th International Conference on Narrow Gap Systems (NGS)
CY AUG 01-05, 2011
CL Campus Virginia Tech, Blacksburg, VA
SP Virginia Tech, Bradley Dept Elect & Comp Engn, Dept Phys, Virginia Tech, Advance VT, Coll Sci, Dept Mat Sci & Engn, Virginia Tech, Off Vice President Res, Virginia Tech, Inst Crit Technol & Appl Sci (ICTAS), Univ Oklahoma, Coll Engn, BAE Syst, Coherent Inc, Oxford Instruments, Janis Res, Wiley, Cryo Industries, Nikon Instruments, STAIB Instruments, Pearson Educ, Amer Elements
HO Campus Virginia Tech
DE Infrared detectors; III-V semiconductors; dilute nitrides; dilute
   bismides
AB Infrared (IR) detector materials based on III-V semiconductors are an affordable alternative to HgCdTe, which is the current material of choice for most high performance IR focal plane array systems fielded in the Army. Based on the assumption that III-V compounds do not have an inherently small bandgap enabling operation out to 10 mu m, the long wave infrared (LWIR) range, there has been substantial research investment in superlattice (SL) approaches. For this reason, quantum structures such as quantum well IR photodetectors (QWIPs) and typeII strained-layer superlattices (SLS) are grown to take advantage of confinement effects and to induce an effective bandgap in the desired range. The drawbacks of these approaches include inherently low quantum efficiencies and operating temperature for QWIPs, and very short minority carrier lifetimes for SLS detectors. In this presentation, we will discuss approaches for developing III-V, direct bandgap, dilute N and Bi alloys grown by molecular beam epitaxy (MBE) for LWIR applications.
C1 [Sarney, W. L.; Svensson, S. P.; Hier, H.] USA, Res Lab, RDRL SEE I, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
   [Donetsky, D.; Wang, D.; Shterengas, L.; Suchalkin, S.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
RP Sarney, WL (reprint author), USA, Res Lab, RDRL SEE I, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
FU Missile Defense Agency [W911NF0720086]
FX We acknowledge support by the Missile Defense Agency under contract
   W911NF0720086 for the dilute nitrides work.
NR 6
TC 3
Z9 3
U1 0
U2 7
PU AMER INST PHYSICS
PI MELVILLE
PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA
SN 0094-243X
BN 978-0-7354-0993-4
J9 AIP CONF PROC
PY 2011
VL 1416
BP 59
EP 61
DI 10.1063/1.3671698
PG 3
WC Engineering, Electrical & Electronic; Physics, Applied
SC Engineering; Physics
GA BZC63
UT WOS:000301110800014
ER

PT S
AU Emara, AM
   Berkman, EA
   Zavada, J
   El-Masry, NA
   Bedair, SM
AF Emara, Ahmed M.
   Berkman, E. Acar
   Zavada, J.
   El-Masry, Nadia A.
   Bedair, S. M.
BA Wetzel, C
   Khan, A
BF Wetzel, C
   Khan, A
TI Strain relaxation in InxGa1-xN/GaN quantum well structures
SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 8,
   NO 7-8
SE Physica Status Solidi C-Current Topics in Solid State Physics
LA English
DT Proceedings Paper
CT International Workshop on Nitride Semiconductors (IWN)/Fall Meeting of
   the European-Materials-Research-Society (E-MRS)/Symposium N/Symposium H
CY SEP 19-24, 2010
CL Tampa, FL
SP European Mat Res Soc (EMRS)
DE InGaN; strain relaxation; GaN-LED
ID GAN-ALN; FIELD; DEPENDENCE
AB We report on the thickness dependence of strain relaxation in InxGa1-xN/GaN for single and multiple quantum-well structures. For InGaN wells thicker than a certain value gradual relaxation occurs and can be presented by two relaxation mechanisms. The first is related to the relaxation of the InGaN well, and the second to the relaxation of the whole multiple quantum well structure. We have also found that the onset of relaxation of multiple quantum wells depends on the number of quantum wells. (C) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
C1 [Emara, Ahmed M.; Bedair, S. M.] North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
   [Berkman, E. Acar; El-Masry, Nadia A.] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
   US Army, Res Off, Res Triangle Pk, NC 27709 USA.
RP Bedair, SM (reprint author), North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
EM bedair@ncsu.edu
FU United State Army Research Office; NSF under the IR/D programs
FX The work is supported by the United State Army Research Office. NEM and
   JMZ acknowledge support from NSF under the IR/D programs. We would like
   to thank Aadhithya Hosalli for his help.
NR 14
TC 5
Z9 5
U1 0
U2 6
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY
SN 1862-6351
J9 PHYS STATUS SOLIDI C
PY 2011
VL 8
IS 7-8
DI 10.1002/pssc.201000984
PG 4
WC Materials Science, Multidisciplinary; Physics, Applied; Physics,
   Condensed Matter
SC Materials Science; Physics
GA BZG94
UT WOS:000301581500008
ER

PT S
AU Wright, J
   Moe, C
   Sampath, AV
   Garrett, GA
   Wraback, M
AF Wright, Jonathan
   Moe, Craig
   Sampath, Anand V.
   Garrett, Gregory A.
   Wraback, Michael
BA Wetzel, C
   Khan, A
BF Wetzel, C
   Khan, A
TI Fabrication of periodically poled AlN with sub-micron periods
SO PHYSICA STATUS SOLIDI C: CURRENT TOPICS IN SOLID STATE PHYSICS, VOL 8,
   NO 7-8
SE Physica Status Solidi C-Current Topics in Solid State Physics
LA English
DT Proceedings Paper
CT International Workshop on Nitride Semiconductors (IWN)/Fall Meeting of
   the European-Materials-Research-Society (E-MRS)/Symposium N/Symposium H
CY SEP 19-24, 2010
CL Tampa, FL
SP European Mat Res Soc (EMRS)
DE AlN; periodic poling; polarity inversion; UV
ID GAN; GENERATION; INVERSION; PLASMA
AB We report on the fabrication of periodically poled AlN structures using inductive coupled plasma (ICP) etching and plasma-assisted molecular beam epitaxy (PAMBE). Periodically poled AlN structures are fabricated by first depositing Al polar material on c-plane sapphire substrates and then inverting the polarity through Mg overdoping. Subsequently, a grating with periods between 250 and 750 nm is defined by e-beam lithography and etched into the film by inductive coupled plasma etching to expose stripes of Al-polar material. ICP etching was optimized to produce vertical sidewalls and smooth Al-polar regions. Finally, the patterned substrate is regrown by PAMBE to realize a periodically poled AlN structure. The sharpness of the interface between the Al and N polar regions is found to be dependent upon ICP etch conditions and III-V flux during regrowth. Under III-rich conditions, the alignment of the grating with crystallographic orientation has an important role in the final surface morphology. While lower III-V flux ratios prevent faceting, regrowth of Al-polar material is inhibited near the side-walls of trenches with high aspect ratios. (C) 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
C1 [Wright, Jonathan; Moe, Craig; Sampath, Anand V.; Garrett, Gregory A.; Wraback, Michael] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Wright, J (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
EM jonathan.wright17@us.army.mil
NR 9
TC 1
Z9 1
U1 2
U2 10
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA PAPPELALLEE 3, W-69469 WEINHEIM, GERMANY
SN 1862-6351
J9 PHYS STATUS SOLIDI C
PY 2011
VL 8
IS 7-8
DI 10.1002/pssc.201001163
PG 3
WC Materials Science, Multidisciplinary; Physics, Applied; Physics,
   Condensed Matter
SC Materials Science; Physics
GA BZG94
UT WOS:000301581500101
ER

PT S
AU Heard, WF
   Basu, PK
   Slawson, T
   Nordendale, NA
AF Heard, W. F.
   Basu, P. K.
   Slawson, T.
   Nordendale, N. A.
BE Guagliano, M
   Vergani, L
TI Characterization and performance optimization of a cementitious
   composite for quasi-static and dynamic loads
SO 11TH INTERNATIONAL CONFERENCE ON THE MECHANICAL BEHAVIOR OF MATERIALS
   (ICM11)
SE Procedia Engineering
LA English
DT Proceedings Paper
CT 11th International Conference on the Mechanical Behavior of Materials
   (ICM)
CY 2011
CL Como, ITALY
DE Material characterization; fiber reinforced concrete; geopolymer cement
AB The U.S. Army Engineer Research and Development Center has conducted multi-scale material research directed towards enhancing the response of a rapid-set, high-strength geopolymer cement under quasi-static and dynamic loads. Four unique tensile experiments were conducted to characterize and optimize material response of the fiber, matrix and interface. Single-fiber direct tension and single-fiber pull-out experiments were conducted with quasi-static and dynamic loads. Flexure from third-point loading and direct uniaxial tension of the fiber reinforced composite experiments were conducted with quasi-static loads. Initial results are presented for the ongoing research. (C) 2011 Published by Elsevier Ltd. Selection and peer-review under responsibility of ICM11
C1 [Heard, W. F.; Basu, P. K.; Nordendale, N. A.] Vanderbilt Univ, Dept Civil & Environm Engn, VU Stn B 351831,2301 Vanderbilt Pl, Nashville, TN 37235 USA.
   [Heard, W. F.; Slawson, T.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Nordendale, NA (reprint author), Vanderbilt Univ, Dept Civil & Environm Engn, VU Stn B 351831,2301 Vanderbilt Pl, Nashville, TN 37235 USA.
EM William.f.heard@usace.army.mil
FU Director, Geotechnical and Structures Laboratory
FX Permission to publish was granted by Director, Geotechnical and
   Structures Laboratory.
NR 4
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1877-7058
J9 PROCEDIA ENGINEER
PY 2011
VL 10
BP 3020
EP 3025
DI 10.1016/j.proeng.2011.04.500
PG 6
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA BYU61
UT WOS:000300451303009
ER

PT S
AU D'Aries, LJ
AF D'Aries, Lawrence J.
BE Guagliano, M
   Vergani, L
TI Design, development, testing and deployment of the world's first fully
   automated individual body armor x-ray inspection system
SO 11TH INTERNATIONAL CONFERENCE ON THE MECHANICAL BEHAVIOR OF MATERIALS
   (ICM11)
SE Procedia Engineering
LA English
DT Proceedings Paper
CT 11th International Conference on the Mechanical Behavior of Materials
   (ICM)
CY 2011
CL Como, ITALY
DE Non-Destructive Inspection; X-ray; Ceramics; Algorithms
AB With the onset of conflict and great troop deployments into South West Asia in 2003 during Operation Iraqi Freedom, the Radiography Laboratory at the US Army ARDEC was approached to investigate the feasibility of designing an automated inspection system to examine the integrity of all the Small Arms Protective Insert (SAP!) ceramic armor plates currently in service. This amounted to on the order of 1 million units so the need for a high-throughput,fully automated system was apparent; this included automated defect recognition (ADR) software and automated material handling (AMU).
   Among the most challenging imaging artifacts is the tine local variation that arises as a combination of imager noise, photon noise and as a result of the arrangement of the fibers themselves in the plate backing and cover material. In many of these cases, the crack indications are actually smaller than the level of interference imposed by the fine local variations. (C) 2011 Published by Elsevier Ltd. Selection and peer-review under responsibility of ICM11
C1 US Army, Qual Engn & Syst Assurance Directorate QE& SA, Radiog Lab, Armament Res Dev & Engn Ctr ARDEC, Picatinny Arsenal, NJ 07078 USA.
RP D'Aries, LJ (reprint author), US Army, Qual Engn & Syst Assurance Directorate QE& SA, Radiog Lab, Armament Res Dev & Engn Ctr ARDEC, Picatinny Arsenal, NJ 07078 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1877-7058
J9 PROCEDIA ENGINEER
PY 2011
VL 10
DI 10.1016/j.proene.2011.04.478
PG 4
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA BYU61
UT WOS:000300451302147
ER

PT S
AU Nordendale, NA
   Heard, WF
   Basu, PK
AF Nordendale, N. A.
   Heard, W. F.
   Basu, P. K.
BE Guagliano, M
   Vergani, L
TI Multi scale behavior of short-fiber reinforced cementitious material
   under ballistic impact
SO 11TH INTERNATIONAL CONFERENCE ON THE MECHANICAL BEHAVIOR OF MATERIALS
   (ICM11)
SE Procedia Engineering
LA English
DT Proceedings Paper
CT 11th International Conference on the Mechanical Behavior of Materials
   (ICM)
CY 2011
CL Como, ITALY
DE cementitious; impact; multiscale; short-fiber
AB Fiber reinforced cementitious material is optimized for improved ballistic impact resistance with respect to type and size of fiber, interfacial bond behavior, and volumetric ratio of fiber. Apart from laboratory testing, a multiscale modeling scheme is developed based on a series of problems devised for the purpose. (C) 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of ICM11
C1 [Nordendale, N. A.; Basu, P. K.] Vanderbilt Univ, Dept Civil & Environm Engn, VU Stn B 351831,2301 Vanderbilt Pl, Nashville, TN 37235 USA.
   [Heard, W. F.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Nordendale, NA (reprint author), Vanderbilt Univ, Dept Civil & Environm Engn, VU Stn B 351831,2301 Vanderbilt Pl, Nashville, TN 37235 USA.
EM p.k.basu@vanderbilt.edu
FU U.S. Army-ERDC
FX Research funding from U.S. Army-ERDC.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1877-7058
J9 PROCEDIA ENGINEER
PY 2011
VL 10
DI 10.1016/j.proeng.2011.04.044
PG 6
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA BYU61
UT WOS:000300451300041
ER

PT S
AU Bluman, J
   Klosky, JL
AF Bluman, James
   Klosky, J. Ledlie
GP IEEE
TI Jump-starting a Senior-level Capstone Project through Hands-on
   Laboratory Exercises
SO 2011 FRONTIERS IN EDUCATION CONFERENCE (FIE)
SE Frontiers in Education Conference
LA English
DT Proceedings Paper
CT 41st Annual Frontiers in Education Conference (FIE)
CY OCT 12-15, 2011
CL Rapid City, SD
SP IEEE Educ Soc, IEEE Comp Soc, Amer Soc Engn Educ (ASEE), Educl Res Methods (ERM), Inst Elect & Elect Engineers (IEEE), S Dakota Sch Mines & Technol
DE Capstone project management; active learning styles; small wind turbine
   design
AB Many universities incorporate either a senior-level thesis research requirement or a senior-level capstone design experience for their engineering majors. One of the biggest challenges in advising such projects is providing a means for students to make meaningful progress early in the project timeline, very often due to the steep learning curve associated with the technical details of the projects. This paper reports on a technique that requires students to complete a series of laboratory exercises designed to give them an operational awareness of the technical issues associated with small wind turbines. The three main efforts required of students were characterizing the efficiency of small generators, characterizing the efficiency of different wind turbine designs, and determining the charging characteristics of lead-acid batteries. This technique has been found to be much more effective than classroom-style instruction or pure literature review, most likely because it appeals to active, visual, and sequential learning styles. This technique, which is based on earlier work in this area, is broadly applicable to many engineering capstone design efforts. Survey data and project performance data will be presented and the effectiveness of the method is evaluated.
C1 [Bluman, James; Klosky, J. Ledlie] US Mil Acad, West Point, NY 10996 USA.
RP Bluman, J (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM james.bluman@us.army.mil; Ledlie.Klosky@usma.edu
NR 12
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 0190-5848
BN 978-1-61284-469-5
J9 PROC FRONT EDUC CONF
PY 2011
PG 6
WC Computer Science, Interdisciplinary Applications; Education, Scientific
   Disciplines; Engineering, Electrical & Electronic
SC Computer Science; Education & Educational Research; Engineering
GA BYZ96
UT WOS:000300879800115
ER

PT S
AU Bittel, BC
   Lenahan, PM
   Ryan, JT
   Fronheiser, J
   Lelis, AJ
AF Bittel, B. C.
   Lenahan, P. M.
   Ryan, J. T.
   Fronheiser, J.
   Lelis, A. J.
GP IEEE
TI Spin Dependent Charge Pumping: A New Tool for Reliability Studies
SO 2011 IEEE INTERNATIONAL INTEGRATED RELIABILITY WORKSHOP FINAL REPORT
   (IRW)
SE IEEE International Integrated Reliability Workshop Final Report
LA English
DT Proceedings Paper
CT IEEE International Integrated Reliability Workshop Final Report (IIRW)
CY OCT 16-20, 2011
CL S Lake Tahoe, CA
SP IEEE Electron Devices Soc, IEEE Reliabil Soc, Stanford Univ, Univ California Berkeley, IEEE
ID RECOMBINATION; INTERFACE; DEFECTS
AB We have developed a new technique, spin dependent charge (SDCP) pumping which combines the unrivaled analytical power of EPR to identify the atomic scale nature of point defects with charge pumping, a widely used electrical characterization technique used to study interface/near interface defects in MOSFETs. We demonstrate SDCP to be a very powerful tool with potential to be of widespread use to the MOSFET reliability community.
C1 [Bittel, B. C.; Lenahan, P. M.] Penn State Univ, University Pk, PA 16802 USA.
   [Ryan, J. T.] NIST, University Pk, PA 16802 USA.
   [Fronheiser, J.] GE Global Res, University Pk, PA 16802 USA.
   [Lelis, A. J.] US Army Res Lab, University Pk, PA 16802 USA.
RP Bittel, BC (reprint author), Penn State Univ, University Pk, PA 16802 USA.
EM bcb183@psu.edu
FU U.S. Department of Commerce [NIST 60NANB10D109]; US Army Research
   Laborator
FX This work was prepared with the support of the U.S. Department of
   Commerce under Award No. NIST 60NANB10D109 and the US Army Research
   Laborator
NR 13
TC 0
Z9 0
U1 0
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
SN 1930-8841
BN 978-1-4577-0115-3
J9 INT INTEG REL WRKSP
PY 2011
BP 142
EP 145
PG 4
WC Engineering, Electrical & Electronic
SC Engineering
GA BYV54
UT WOS:000300607100036
ER

PT J
AU Kanterakis, E
   Su, W
AF Kanterakis, Emmanuel
   Su, Wei
GP IEEE
TI OFDM Signal Classification in Frequency Selective Rayleigh Channels
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE OFDM; Blind; Estimation; Parameters
ID TIME
AB OFDM signal classification has become an important requirement in many cognitive radios and military systems. Implementing such a requirement under Frequency Selective Rayleigh fading is a challenging task. In this paper, we explore different blind OFDM parameter and channel estimation techniques based on Maximum Likelihood techniques and higher order signal processing to ascertain the reception of an OFDM waveform. The algorithms presented are robust to different channel fading and low signal to noise ratio environments.
C1 [Kanterakis, Emmanuel] CACI Int, Eatontown, NJ 07724 USA.
   [Su, Wei] US Army, RDECOM, CERDEC, Ft Monmouth, NJ 07703 USA.
RP Kanterakis, E (reprint author), CACI Int, Eatontown, NJ 07724 USA.
NR 6
TC 2
Z9 2
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1
EP 6
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500001
ER

PT J
AU Dunnegan, R
   Van Vechten, D
   Gupta, D
AF Dunnegan, Rick
   Van Vechten, Deborah
   Gupta, Deepnarayan
GP IEEE
TI Precision Polarized Bandwidth Expansion
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB The Armed Forces has a long standing requirement for a robust global communications infrastructure to support real time operations. The bandwidth elasticity continues to be tested as demand continues to grow in support of multiple theater events. The US Army CERDEC Space and Terrestrial Communications Directorate, coupled with the US Navy is doing relevant research and development in order to expand the boundaries within the physics that govern bandwidth usage today. Such bandwidth economizing will aid systems being developed in support of both MILSATCOM and commercial frequency bands at the data rates required to support the battlefield. High speed digitization coupled with carrier code identifiers will be used to achieve usage beyond the conventional means of operation. In the development of polarizing with precision, multiple sampling techniques at various frequency domains will be evaluated for best suited applications. The US Army CERDEC SATCOM laboratories located at Aberdeen Proving Ground, MD is working with the US Navy and industry to evaluate and determine the most effective approach in expanding polarization techniques. The focus of testing will primarily consist of data recovery with signals of interest operating on the same frequency in three or more different polarizations simultaneously. Results from such testing will be used to effect polarizing with precision and determine the predictability using discriminate line of site and long haul applications. Functional variables will include angle of arrival, geographical origin of emission versus destination of delivery. Discussions will be principally focused on accomplishing data recovery using multi variant polarization techniques.
C1 [Dunnegan, Rick] USA, C4ISR, CERDEC S&TCD, Aberdeen Proving Ground, MD USA.
   [Van Vechten, Deborah] US Navy, C4ISR, Off Naval Res, Aberdeen Proving Ground, MD USA.
   [Gupta, Deepnarayan] Hypres Inc, 175 Clearbrook Rd, Elmsford, NY 10523 USA.
RP Dunnegan, R (reprint author), USA, C4ISR, CERDEC S&TCD, Aberdeen Proving Ground, MD USA.
NR 8
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 45
EP 50
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500009
ER

PT J
AU Ferrett, T
   Valenti, MC
   Torrieri, D
AF Ferrett, Terry
   Valenti, Matthew C.
   Torrieri, Don
GP IEEE
TI Noncoherent Digital Network Coding Using Multi-tone CPFSK Modulation
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
ID FSK
AB Digital network coding is a relaying technique that increases throughput in two-way relay networks. In contrast with analog network coding, which relays received analog signals plus noise, digital network coding relays digital codewords. The digital codewords are created by demodulation, channel decoding, and re-encoding at the relay. By using FSK and noncoherent reception, the relay may operate without knowledge of the phases of the signals transmitted by the two source terminals. In this paper, previous work on binary FSK is extended to multi-tone FSK, where the number of tones may be any power of 2. The relay receiver is formulated for any number of tones that is a power of two. Binary FSK is compared against quaternary FSK, which requires no expansion of bandwidth compared with binary FSK. The comparison is made using two metrics: the simulated bit-error rate (both with and without an outer turbo code), and the binary information rate between the sources and relay. The results illustrate that the energy-efficiency advantage of quaternary FSK on a point-to-point link is magnified when it is applied to digital network coding.
C1 [Ferrett, Terry; Valenti, Matthew C.] West Virginia Univ, Morgantown, WV 26506 USA.
   [Torrieri, Don] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Ferrett, T (reprint author), West Virginia Univ, Morgantown, WV 26506 USA.
OI Valenti, Matthew/0000-0001-6089-0509
FU National Science Foundation [CNS-0750821]; United States Army Research
   Laboratory [W911NF-10-0109]
FX M.C. Valenti and T. Ferrett were sponsored by the National Science
   Foundation under Award No. CNS-0750821 and by the United States Army
   Research Laboratory under Contract W911NF-10-0109.
NR 9
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 299
EP 304
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500052
ER

PT J
AU Lu, JS
   Bertoni, HL
   Han, AX
   Chrysanthou, C
   Boksiner, J
AF Lu, Jonathan S.
   Bertoni, Henry L.
   Han, Alexander X.
   Chrysanthou, Chrysanthos
   Boksiner, Jeffery
GP IEEE
TI Dependence of Radio Channel Characteristics on Terrain Variability in
   Hilly/Mountainous Regions
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE path gain; path loss; tapped delay line; slow fading; Tirem; scattering;
   non-specular; mountain; rural propagation
AB This paper investigates how the temporal response and spatial fading statistics for mobile-to-mobile links in hilly and mountainous terrain depend on terrain variations. Fading statistics are generated from Monte Carlo simulations using several terrain databases. These simulations employ a computer code that accounts for diffraction over terrain obstacles and for non-specular scattering from terrain elements. Based on the simulations, we have developed path loss, slow fading, and tapped delay line models for use in the evaluation of communication systems.
C1 [Lu, Jonathan S.; Bertoni, Henry L.; Han, Alexander X.] NYU, Wireless Internet Ctr Adv Technol, Polytech Inst, Brooklyn, NY USA.
   [Chrysanthou, Chrysanthos; Boksiner, Jeffery] US Army, Dept Elect Res Dev & Engn Ctr, Aberdeen Proving Ground, MD 21005 USA.
RP Lu, JS (reprint author), NYU, Wireless Internet Ctr Adv Technol, Polytech Inst, Brooklyn, NY USA.
EM hbertoni@poly.edu
NR 5
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 441
EP 446
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500076
ER

PT J
AU Xu, JL
   Su, W
   Zhou, MC
AF Xu, Jefferson L.
   Su, Wei
   Zhou, Mengchu
GP IEEE
TI Asynchronous and High-Accuracy Digital Modulated Signal Detection by
   Sensor Networks
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE Modulation classification; maximum likelihood test; wireless sensor
   networks; equal gain combining; maximal-ratio combining; distributed
   detection
ID CLASSIFICATION; RADIO
AB Adaptive modulation can be used to significantly enhance the spectrum utilization for both civilian applications, e. g., cognitive radio, and military ones. It requires a receiver to follow the modulation variation of a transmitter dynamically and automatically. Binary automatic modulation detection technology has been applied to detect the modulation scheme for adaptive modulation. Modulation classification was proposed for a multi-sensor scenario in our prior work using a distributed algorithm to enhance the detection accuracy. In this paper, the function of blind detection by the wireless sensor network (WSN) is further extended to support multiple modulation hypotheses. Besides providing spatial diversities, distributed sensors perform complicated calculations of likelihood functions and use the master node (radio) for data fusion and maximum likelihood testing. The proposed method requires no synchronization across the network and works well with low transmission bandwidth. Both analytical and numerical results are presented to validate its effectiveness.
C1 [Xu, Jefferson L.] Cirrus Log Inc, Austin, TX 78746 USA.
   [Su, Wei] US Army RDECOM, Commun Elect RD&E Ctr, Aberdeen Proving Ground, MD 21005 USA.
   [Zhou, Mengchu] New Jersey Inst Technol, Dept ECE, Newark, NJ 07102 USA.
RP Xu, JL (reprint author), Cirrus Log Inc, Austin, TX 78746 USA.
EM jefferson.xu@cirrus.com; mengchu.zhou@njit.edu
NR 15
TC 6
Z9 6
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 589
EP 594
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500101
ER

PT J
AU Lai, HQ
   Chen, Y
   Liu, KJR
AF Lai, Hung-Quoc
   Chen, Yan
   Liu, K. J. Ray
GP IEEE
TI COALITION FORMATION GAMES FOR ENERGY-EFFICIENT WIRELESS NETWORK COCAST
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE Cooperative communications; wireless network cocast; coalition formation
   games; merge process; energy efficiency
AB Wireless network cocast (WNC) is a cooperative communication protocol that overcomes the issues of imperfect frequency and timing synchronization while achieving spatial diversity to substantially reduce transmit power over direct transmission (DTX). Due to additional processing power in receiving and retransmitting each other information, however, not all nodes and WNC networks result in energy efficiency. To ensure energy efficient WNC networks, a TDMA-based merge process based on coalition formation games is proposed to orderly form cooperative groups. A node is merged into a cooperative group if the merge leads to power saving without causing additional power burden to individual nodes. Simulation shows that WNC networks require much less power to provide comparable quality of service of DTX networks. In addition, WNC networks achieve even power distribution, which improves the network lifetime.
C1 [Lai, Hung-Quoc] USA, RDECOM CERDEC, RDER STA DS, Aberdeen Proving Ground, MD 21005 USA.
   [Lai, Hung-Quoc; Chen, Yan; Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA.
RP Lai, HQ (reprint author), USA, RDECOM CERDEC, RDER STA DS, Aberdeen Proving Ground, MD 21005 USA.
FU Natural Sciences and Engineering Research Council (NSERC) of Canada
FX This research is supported by the Natural Sciences and Engineering
   Research Council (NSERC) of Canada.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 741
EP 746
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500126
ER

PT J
AU Zheng, Q
   Cao, GH
   La Porta, T
   Swami, A
AF Zheng, Qiang
   Cao, Guohong
   La Porta, Tom
   Swami, Ananthram
GP IEEE
TI Detecting and Localizing Large-Scale Router Failures Using Active Probes
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB Detecting the occurrence of large-scale router failures and localizing the failed routers are critical to enhancing network reliability. We propose a two-phase approach for detecting and localizing large-scale router failures using traceroute-like active probes. To detect large-scale router failures, the detection phase is periodically invoked to probe all routers. When detecting large-scale router failures, the localization phase is triggered to identify the failed routers. We reduce the probing cost by avoiding three types of useless probes. For the routers whose status cannot be identified by probes, we develop a distance based method to estimate their failure probability. Experimental results based on ISP topologies show that the accuracy of our approach is higher than 96.5%, even when only 10% of routers are connected by end systems for probing. Compared with prior works, the proposed approach achieves much higher accuracy with lower probing cost.
C1 [Zheng, Qiang; Cao, Guohong; La Porta, Tom] Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
   [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA.
RP Zheng, Q (reprint author), Penn State Univ, Dept Comp Sci & Engn, University Pk, PA 16802 USA.
EM quz103@cse.psu.edu; gcao@cse.psu.edu; tlp@cse.psu.edu;
   ananthram.swami@us.army.mil
FU Defense Threat Reduction Agency [HDTRA1-10-1-0085]
FX This work was supported in part by the Defense Threat Reduction Agency
   under grant HDTRA1-10-1-0085.
NR 17
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1170
EP 1175
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500196
ER

PT J
AU Zhang, DF
   Yu, W
   Hardy, R
AF Zhang, Difan
   Yu, Wei
   Hardy, Rommie
GP IEEE
TI A Distributed Network-Sensor Based Intrusion Detection Framework in
   Enterprise Networks
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE Distributed Intrusion Detection; Network Sensors; Enterprise Networks
AB In this paper, we propose a distributed network sensor based intrusion detection framework to detect the emerging stealthy attacks, including malware propagation in enterprise networks. In this framework, we consider the distributed detection agents on hosts, which monitor network traffic and other anomalies on the hosts, efficiently process and aggregate detection data, and generates attack alerts. The control center collects information from the distributed detection agents and detects the attacks and compromised hosts. We develop techniques, including a deep packet inspection to process network traffic efficiently, detection algorithms (e. g., passive/ active discovery mechanisms to identify compromised hosts). To demonstrate the effectiveness of our proposed framework, we have implemented a proof-of-concept system and conducted real-world experiments. Our data show the effectiveness of our approach to detect attacks, including the malware propagation.
C1 [Zhang, Difan; Yu, Wei] Towson Univ, Dept Comp & Informat Sci, Towson, MD 21252 USA.
   [Hardy, Rommie] Army Res Lab, Adelphi, MD 20783 USA.
RP Zhang, DF (reprint author), Towson Univ, Dept Comp & Informat Sci, Towson, MD 21252 USA.
EM alex@osqdu.org; wyu@towson.edu; rhardy@arl.army.mil
FU ARL (Army Research Laboratory) [W911NF-11-1-0193]
FX Research was sponsored by the ARL (Army Research Laboratory) and was
   accomplished under the grant Number W911NF-11-1-0193. The views and
   conclusions contained in this document are those of the authors and
   should not be interpreted as representing the official policies, either
   expressed or implied, of the Army Research Laboratory or the U.S.
   Government. The U.S. Government is authorized to reproduce and
   distribute reprints for Government purposes notwithstanding any
   copyright notation here on.
NR 16
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1195
EP 1200
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500200
ER

PT J
AU Govindan, K
   Wang, XL
   Khan, M
   Dogan, G
   Zeng, K
   Powell, GM
   Brown, T
   Abdelzaher, T
   Mohapatra, P
AF Govindan, Kannan
   Wang, Xinlei
   Khan, Maifi
   Dogan, Gulustan
   Zeng, Kai
   Powell, Gerald M.
   Brown, Ted
   Abdelzaher, Tarekh
   Mohapatra, Prasant
GP IEEE
TI PRONET: Network Trust Assessment Based on Incomplete Provenance
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB This paper presents a tool ProNet, that is used to obtain the network trust based on incomplete provenance. We consider a multihop scenario where a set of source nodes observe an event and disseminate their observations as an information item through a multihop path to the command center. Nodes are assumed to embed their provenance details on the information content. Received provenance may not be complete at the command center due to attackers dropping provenance or the unavailability of provenance. We design ProNet, a tool which is at the command center that acts on the received information item to determine the information trust, node-level trust and sequence-level trust. ProNet contains three steps. In the first step it reconstructs the complete provenance details of received information from the available provenance. In the second step it employs a data classification scheme to classify the data into a good and bad pool. In the third step it employs pattern mining on the reconstructed provenance of bad data pools to determine the frequently appearing node and node sequence. This frequent appearance will quantify the trust level of nodes and node sequence. Now an information quality/trust level of newly received information can be determined based on the occurrences of these node/sequence patterns on the provenance data. We provide a detailed analysis on false positive and false negatives.
C1 [Govindan, Kannan; Wang, Xinlei; Zeng, Kai; Mohapatra, Prasant] Univ Calif Davis, Davis, CA 95616 USA.
   [Khan, Maifi; Abdelzaher, Tarekh] Univ Illinois, Urbana Champaign, Champaign, IL 60801 USA.
   [Dogan, Gulustan; Brown, Ted] CUNY, New York, NY 10003 USA.
   [Powell, Gerald M.] Army Res Lab, Adelphi, MD 20783 USA.
RP Govindan, K (reprint author), Univ Calif Davis, Davis, CA 95616 USA.
EM gkannan@cs.ucdavis.edu; oscar@cs.ucdavis.edu; maifi@cs.uiuc.edu;
   gulustan@gc.cuny.edu; kzeng@cs.ucdavis.edu; gerald.m.powell@us.army.mi;
   TBrown@gc.cuny.edu; zaher@cs.uiuc.edu; prasant@cs.ucdavis.edu
FU Army Research Laboratory [W911NF-09-2-0053]
FX This research was sponsored by the Army Research Laboratory and was
   accomplished under Cooperative Agreement Number W911NF-09-2-0053. The
   views and conclusions contained in this document are those of the
   authors and should not be interpreted as representing the official
   polices, either expressed or implied, of the Army Research Laboratory or
   the U.S. Government. The U.S Government is authorized to reproduce and
   distribute reprints for Government purposes not withstanding any copy
   right notation here on.
NR 11
TC 3
Z9 3
U1 1
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1213
EP 1218
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500203
ER

PT J
AU Cannon, CT
   Pellegrino, DA
   Hewett, TT
   Regli, WC
   Oddo, G
AF Cannon, Christopher T.
   Pellegrino, Donald A.
   Hewett, Thomas T.
   Regli, William C.
   Oddo, Giovanni
GP IEEE
TI Human-Centered Network Visualizer: Visual Abstractions of Network
   Operations in a Tactical Environment
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB We present visualization requirements and designs for the Human-Centered Network Visualizer (NetViz) to assist the US Army Brigade Signals Officer (S6) soldiers with their daily activities. These are based on interactions with both retired and active duty S6 soldiers. To assure information dominance it is increasingly important for the Army that the S6 and Network Operations Group are able to obtain and provide an accurate situational awareness from data received over the network. This paper addresses three challenges faced by the S6: (1) mentally integrating and correlating information from disparate tools, (2) processing and interpreting that information for a commander who may have limited technical knowledge, and (3) reducing the amount of downtime resulting from any disruption through the creation of a contingency plan. The NetViz designs abstract and unify data required by an S6 into a single view. They allow for the visualization of data to support S6 reporting during an update brief. Visual designs for "what if" scenarios and future events also facilitate planning for both the expected and the unexpected. This paper describes our interactions with S6 soldiers along with the resultant visualization enhancement based upon information provided. We also present sample visual abstractions based on these interactions along with definitions of their importance and illustrations of their potential use in field.
C1 [Cannon, Christopher T.; Pellegrino, Donald A.; Hewett, Thomas T.; Regli, William C.] Drexel Univ, AJ Drexel ACIN Inst, Philadelphia, PA 19104 USA.
   [Oddo, Giovanni] US Army, CERDEC, CECOM, Aberdeen Proving Ground, MD USA.
RP Cannon, CT (reprint author), Drexel Univ, AJ Drexel ACIN Inst, Philadelphia, PA 19104 USA.
EM ctc82@drexel.edu; st96wym4@drexel.edu; hewett@drexel.edu;
   regli@drexel.edu
NR 9
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1291
EP 1296
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500216
ER

PT J
AU Cho, JH
   Swami, A
   Cook, T
AF Cho, Jin-Hee
   Swami, Ananthram
   Cook, Trevor
GP IEEE
TI Combinatorial Auction-based Multiple Dynamic Mission Assignment
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE combinatorial auction; single-item auction; task assignment; dynamic
   mission; mobile ad hoc networks; auction bundle algorithm; single-minded
   auction
ID MANAGEMENT
AB This paper proposes a combinatorial auction based approach to solving a multiple dynamic mission assignment (MDMA) problem. The problem presents itself in scenarios in which mobile nodes perform multiple missions, and the missions are supported by multiple nodes in a mobile ad hoc network. In this scenario, missions may dynamically arrive, may have to be completed at different times, and different numbers of members may be required for mission execution. The proposed MDMA protocol aims to minimize communication overhead caused by the mission assignment while maximizing each node's utilization (i.e., minimizing its idle time) and maximizing the fraction of mission completion over the initial missions given. We compare the proposed MDMA protocol with baseline mechanisms such as a single-item auction or a single-minded auction based on the above performance metrics.
C1 [Cho, Jin-Hee; Swami, Ananthram; Cook, Trevor] USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
RP Cho, JH (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
EM jinhee.cho.civ@mail.mil; ananthram.swami.civ@mail.mil;
   trevor.j.cook.civ@mail.mil
NR 13
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1327
EP 1332
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500222
ER

PT J
AU Kant, L
   McAuley, A
   Manousakis, K
   Chadha, R
   Chiang, CJ
   Gottlieb, Y
   Graff, C
   Patel, M
   Bowcock, J
   Moeltner, K
   Yee, D
AF Kant, L.
   McAuley, A.
   Manousakis, K.
   Chadha, R.
   Chiang, C-J.
   Gottlieb, Y.
   Graff, C.
   Patel, M.
   Bowcock, J.
   Moeltner, K.
   Yee, D.
GP IEEE
TI On the Application of Cognitive Network Design to MANET Network
   Management
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE MANET Management; Cognitive Network Design; Robustness; Network
   Lifetime; Game Theoretic Topology Control; Network Maintenance Policies
AB The requirement for resilient networks of the types envisioned in the NCW paradigm underscores the need for both a systematic network design tool and an adaptive network management system that implements the design and ensures that the design continues to support mission requirements when the network is in operation. The Cognitive Network Engineering Design and Analysis Tool (C-NEDAT), jointly developed by Telcordia and CERDEC, is an analytic design tool rooted in formal network science based approaches that can be used to rapidly create robust survivable MANET designs. The TITAN (Tactical Information Technology for Assured Networks) Network Management System (NMS), jointly developed by Telcordia and CERDEC, is a policy-driven network management system that enables automated management of tactical networks based on a given mission description. Typically, networks are designed based on a maneuver plan and the NMS automates the management of the resulting network by reconfiguring the network in real time based on monitored information and root cause analysis. However due to the unpredictable dynamics inherent in the military networking environment (e.g., loss of mission critical nodes, drastic deviations from the mission plan, etc), the NMS will encounter situations where the specified reconfiguration actions cannot restore the network state to one where mission requirements are met. Such a situation calls for a dynamic re-design based on the actual network state to provide a new configuration that can meet the mission requirements, which can be instantiated by the NMS. We address this critical need and provide, in this paper, a novel real-time application of C-NEDAT to complement the network management function of TITAN by providing the ability to re-design the network in real-time in order to meet the mission requirements.
C1 [Kant, L.; McAuley, A.; Manousakis, K.; Chadha, R.; Chiang, C-J.; Gottlieb, Y.] Telcordia Technol Inc, Appl Res, Piscataway, NJ 08854 USA.
   [Graff, C.] US Army, CERDEC, Ft Monmouth, NJ USA.
   [Patel, M.; Bowcock, J.; Moeltner, K.; Yee, D.] US Army, CERDEC, Aberdeen, MD USA.
RP Kant, L (reprint author), Telcordia Technol Inc, Appl Res, Piscataway, NJ 08854 USA.
EM lkant@research.telcordia.com
FU <it>U.S. Army CERDEC</it> [<it>DAAD-19-01-C-0062</it>, W15P7T-08-C-P213]
FX <IT>This work was sponsored by U.S. Army CERDEC under contracts
   DAAD-19-01-C-0062 and W15P7T-08-C-P213</IT>
NR 3
TC 0
Z9 0
U1 1
U2 2
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1428
EP 1433
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500240
ER

PT J
AU Acosta, JC
   Medrano, JD
AF Acosta, Jaime C.
   Medrano, John D.
GP IEEE
TI Using a Novel Blending Method Over Multiple Network Connections for
   Secure Communication
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB In the field of computer security, covert communication is usually seen as adversarial, but from another perspective, it can be seen as a way to communicate securely by hiding data from a malicious third party, e.g., an inside attacker. In this light, instead of making data unreadable using encryption, it may be possible to hide from an adversary a secure network infrastructure (consisting of several node endpoints) in network traffic.
   In this paper we describe a novel blending technique that is capable of using as carriers the payload fields of multiple connections including audio, video, and voice over IP (VoIP) streams. The technique executes in three main phases. First the state of the network is analyzed. Next, insertion points are selected based on the protocols, data rates, and randomness characteristics of the network data. Finally, covert data are inserted into packets that are injected into the network. By analyzing the same network traffic the covert receiver identifies the insertion points and extracts the covert messages. In this paper, we evaluate the blending covert method with user datagram protocol (UDP) connections during two network loads. Our results show that our technique works with limited data loss. We also provide an analysis of the trade offs between throughput and detectability.
C1 [Acosta, Jaime C.; Medrano, John D.] USA, Res Lab, White Sands Missile Range, NM 88002 USA.
RP Acosta, JC (reprint author), USA, Res Lab, White Sands Missile Range, NM 88002 USA.
NR 15
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1460
EP 1465
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500245
ER

PT J
AU Dogan, G
   Brown, T
   Govindan, K
   Khan, MMH
   Abdelzaher, T
   Mohapatra, P
   Cho, JH
AF Dogan, Gulustan
   Brown, Theodore
   Govindan, Kannan
   Khan, Mohammad Maifi Hasan
   Abdelzaher, Tarek
   Mohapatra, Prasant
   Cho, Jin-Hee
GP IEEE
TI Evaluation of Network Trust Using Provenance Based on Distributed Local
   Intelligence
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE Provenance; Trust; Information Networks; Distributed Intelligence
AB Provenance can play a significant role in a military information system for supporting the calculation of information trust. A node's trust can change over time after its initial deployment due to various reasons such as energy loss, environmental conditions or exhausting sources. We introduce a node-level trust-enhancing mechanism for information networks using provenance. A unique characteristic of the proposed trust architecture presented here is the use of provenance through the path of the information from source to destination in determining the information trust. In this proposed architecture each node in the system has a trust and provenance vector. Each information item transmitted over the network has a trust value associated with it. Nodes reexamine and update the trust value associated with the information, creating a distributed system that is more flexible and more responsive. As our system allows reconfigurations, initiatives taken by the intermediate nodes such as replacement of untrusted nodes will enhance the network trust in mission critical situations faster than a centralized approach.
C1 [Dogan, Gulustan; Brown, Theodore] CUNY, New York, NY 10021 USA.
   [Govindan, Kannan; Khan, Mohammad Maifi Hasan; Abdelzaher, Tarek] Univ Illinois, Champaign, IL USA.
   [Abdelzaher, Tarek; Mohapatra, Prasant] Univ Calif Davis, Davis, CA USA.
   [Cho, Jin-Hee] US Army, Res Lab, Carlisle, PA USA.
RP Dogan, G (reprint author), CUNY, New York, NY 10021 USA.
EM gdogan@gc.cuny.edu; tbrown@gc.cuny.edu; gkannan@cs.ucdavis.edu;
   mmkhan2@illinois.edu; zaher@illinois.edu; prasant@cs.ucdavis.edu;
   jinhee.cho@us.army.mil
OI Govindan, Kannan/0000-0002-6962-7560
FU Army Research Laboratory; Cooperative Agreement [W911NF-09-2-0053]
FX This research was sponsored by the Army Research Laboratory and was
   accomplished under Cooperative Agreement Number W911NF-09-2-0053.
NR 16
TC 3
Z9 3
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1493
EP 1498
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500250
ER

PT J
AU Martin, MK
   Carley, KM
   Sauk, P
   Perrin, P
   O'Neill, D
   Woolley, A
AF Martin, Michael K.
   Carley, Kathleen M.
   Sauk, Paul
   Perrin, Patrick
   O'Neill, Daniel
   Woolley, Anni
GP IEEE
TI Tracking Commander's Intent in Dynamic Networks
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE BML; Net-Centric; Human Cognition; Meta-Network; Commander's Intent
AB A goal of the Tactical Human Integration of Networked Knowledge (THINK) Army Technology Objective (ATO) is to develop and test a proposed socio-cognitive network analytic method that aims to improve the effective understanding and execution of commander's intent (CI), for a given echelon, based on the interpretation of the operational order (OPORD) and the monitoring of the warfighters' activities, via their communications. Network Text Analysis is used to extract a meta-network model from OPORDs and operational discourse, such as email and chat logs. The contents of this meta-network model are coded using the Battle Management Language (BML), and Dynamic Network Analysis (DNA) techniques are then applied to the extracted data in order to determine the extent to which a Commander's Intent is being accurately followed and to identify points and bases for departure. This will lead to the establishment of new requirements for instrumentation of the net-centric environment for detection of human behavior.
C1 [Martin, Michael K.; Carley, Kathleen M.] Carnegie Mellon Univ, Inst Software Res, Pittsburgh, PA 15213 USA.
   [Sauk, Paul] MITRE, Bedford, MA USA.
   [Perrin, Patrick; O'Neill, Daniel; Woolley, Anni] US Army, RDECOM, CERDEC, C2D Battle Command Div,C2 Cognit Branch, Carlisle, PA USA.
RP Martin, MK (reprint author), Carnegie Mellon Univ, Inst Software Res, Pittsburgh, PA 15213 USA.
EM mkmartin@cs.cmu.edu; kathleen.carley@cs.cmu.edu; psauk@mitre.org;
   patrick.perrin1@us.army.mil; daniel.v.oneill@us.army.mil;
   anni.woolley@us.army.mil
OI Carley, Kathleen M/0000-0002-6356-0238
NR 7
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1517
EP 1522
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500254
ER

PT J
AU From, J
   Perrin, P
   O'Neill, D
   Yen, J
AF From, Jeffrey
   Perrin, Patrick
   O'Neill, Daniel
   Yen, John
GP IEEE
TI Supporting the Commander's Information Requirements: Automated Support
   for Battle Drill Processes Using R-CAST
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE MDMP automation; Battle Drill; R-CAST; Recognition-Primed Decision;
   Cognitive Agents; Information Requirements; Cognitive Performance
ID TEAMWORK; TASK
AB This paper discusses a novel approach that addresses the problem of supporting the Commander's dynamic information requirements through automation of the Military Decision-Making Process (MDMP) for time-constrained environments and training purposes, as part of the Tactical Human Integration of Networked Knowledge (THINK) Army Technology Objective - Research (ATO-R) initiative. We demonstrate this capability with automated user support for the execution of battle drills. Our approach is based on adapting the R-CAST cognitively-inspired agent architecture towards a context-aware anticipation of information requirements. R-CAST is a computational model of the Recognition-Primed Decision (RPD) model, which models human decision making under time stress. R-CAST agents support and collaborate with human decision making teams as both "smart aids" and "effective teammates" by anticipating, investigating, seeking, and interpreting information relevant to decision making. A key feature of R-CAST is that the proactive sharing of information relevant to decision making is automatically generated by the computational RPD model. The fundamental research question being addressed is whether the inclusion of R-CAST in Army staff processes improves said staff understanding and execution of battle tasks. We adapted R-CAST to Battle Drill #26 (i.e., responding to an IED event) as a proof of concept for team decision making under stress and constant switching of modalities. We demonstrate that the use of R-CAST cognitive agents effectively assists the Battle Manager in the S3 cell with auto-filling certain forms required by doctrine in response to the dynamism of the current state of the environment, improving cognitive performance in this task. Our novel approach integrates relevant context in communication, information, and socio-cognitive networks, coupled with cognitive modeling. We report initial findings that we can use the R-CAST cognitive framework to effectively and efficiently develop individual intelligent training tools that understand and support the dynamic information requirements of Commanders.
C1 [From, Jeffrey] USA, Combined Arms Ctr, Mission Command Battle Lab, Ft Leavenworth, KS 66027 USA.
   [Yen, John] Penn State Univ, Coll Informat Sci & Technol, University Pk, PA USA.
   [Perrin, Patrick; O'Neill, Daniel] US Army, RDECOM, CERDEC, Command & Control Cognit Branch, Aberdeen Proving Ground, MD USA.
RP From, J (reprint author), USA, Combined Arms Ctr, Mission Command Battle Lab, Ft Leavenworth, KS 66027 USA.
NR 15
TC 0
Z9 0
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1523
EP 1528
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500255
ER

PT J
AU Suri, N
   Pochet, L
   Sterling, J
   Kohler, R
   Casini, E
   Kovach, J
   Winkler, R
   Budulas, P
AF Suri, Niranjan
   Pochet, Louis
   Sterling, Josh
   Kohler, Ralph
   Casini, Enrico
   Kovach, Jesse
   Winkler, Robert
   Budulas, Peter
GP IEEE
TI Infrastructure, Middleware, and Applications for Portable Cellular
   Devices in Tactical Edge Networks
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE cellular networks; cellular mobile devices; smartphones; Android;
   tactical applications; middleware
ID ENVIRONMENTS OBSERVATIONS; EXPERIENCES
AB The tactical environment requires lightweight devices that are still sufficiently powerful to run a variety of applications to support dismounted soldiers. In the commercial market, competition and demand have driven the mobile phone platform to become a highly capable, programmable environment with devices that have excellent processing, storage, and display capabilities given their cost and size. The Android platform from Google has further increased access to these devices by providing an open source platform that can be programmed in Java and C++. This paper describes a set of middleware services designed to support tactical applications on Android devices, as well as improve communications capabilities from cellular devices. We also describe a candidate set of Android applications to support Tactical users.
C1 [Suri, Niranjan; Casini, Enrico] Florida Inst Human & Machine Cognit IHMC, Pensacola, FL 32502 USA.
   [Pochet, Louis] GMECI, LLC, Dayton, OH USA.
   [Sterling, Josh; Kohler, Ralph] US Air Force, Res Lab, Arlington, VA USA.
   [Kovach, Jesse; Winkler, Robert; Budulas, Peter] US Army, Res Lab, Carlisle, PA USA.
RP Suri, N (reprint author), Florida Inst Human & Machine Cognit IHMC, Pensacola, FL 32502 USA.
FU IHMC; GMECI in collaboration with the US Air Force Research Laboratory
   (AFRL); US Army Research Laboratory (ARL); AFRL [FA8750-11-2-0095]; ARL
   [W911NF-04-2-0013]
FX This effort has been performed jointly by IHMC and GMECI in
   collaboration with the US Air Force Research Laboratory (AFRL) and the
   US Army Research Laboratory (ARL). This effort has also been funded in
   part by AFRL under cooperative agreement FA8750-11-2-0095 and ARL under
   cooperative agreement W911NF-04-2-0013
NR 14
TC 2
Z9 2
U1 0
U2 1
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1541
EP 1546
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500258
ER

PT J
AU Mayk, I
   Regli, W
   Nguyen, D
   Mai, M
   Chan, A
   Urness, T
   Goren, B
   Kizenko, S
   Randles, S
   Jastrebski, Z
   Ruschmeyer, J
   Lehman, L
   McCurdy, M
   Millar, D
   Simmons, I
   Cannon, C
   Kopena, J
   Patwardhan, A
   Tassone, G
   Lindquist, J
   Jewell, G
   Forkenbrock, R
   Nicholson, M
   Koss, F
   Wray, R
   Bradshaw, J
   Lott, J
AF Mayk, I.
   Regli, W.
   Nguyen, D.
   Mai, M.
   Chan, A.
   Urness, T.
   Goren, B.
   Kizenko, S.
   Randles, S.
   Jastrebski, Z.
   Ruschmeyer, J.
   Lehman, Lex
   McCurdy, M.
   Millar, D.
   Simmons, I.
   Cannon, C.
   Kopena, J.
   Patwardhan, A.
   Tassone, G.
   Lindquist, J.
   Jewell, G.
   Forkenbrock, R.
   Nicholson, M.
   Koss, F.
   Wray, R.
   Bradshaw, J.
   Lott, J.
GP IEEE
TI Net-Centric Information and Knowledge Management and Dissemination for
   Data-to-Decision C2 Applications using Intelligent Agents and
   Service-Oriented Architectures
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB The Tactical Information Technologies for Assured Network Operations (TITAN) Program aims to achieve net-centric information and knowledge management and dissemination integrated with data-to-decision C2 Applications. TITAN is a multi-year effort to develop, demonstrate and mature information and knowledge (I&K) management and dissemination (M&D) services spanning multiple echelons and provide support to the network-centric operations process with collaborative military planning and execution monitoring. TITAN integrates heterogeneous, open-source intelligent agents and web services with network-centric communications infrastructures. These agents and services are designed to support users executing the Operations Process for command and control across command echelons from units on the upper tactical internet at brigade and above to units on the lower tactical internet at battalion and below. The result is an adaptive system for collaborative battle command planning, execution and monitoring.
   In delivering TITAN, the team had to engineer novel solutions to several current research problems. These technical contributions include the development of a Battle Command-Warfighter (BCW) interface that integrates planning with situation awareness; definition of interoperability schemas for C2 information sources and services; management of distributed provenance; implementation of a network-centric message bus for communications across different network echelons and radios; and the development of agents and services to support Mission Command planning processes and numerous Data-to-Decision (D2D) threads in a comprehensive manner to execute TRADOC's Multi-Level Scenario. The integrated TITAN system has been demonstrated in numerous settings and was featured at the Ft. Dix C4ISR "On the Move" experiment in summer 2011.
C1 [Mayk, I.; Mai, M.; Chan, A.; Urness, T.; Goren, B.; Kizenko, S.] CERDEC, RDECOM, C2D, Aberdeen Proving Ground, MD 21005 USA.
   [Randles, S.] US Army, Space & Missile Def Command, Carlisle, PA USA.
   [Jastrebski, Z.] L3 Commun, New York, NY USA.
   [Ruschmeyer, J.; Lehman, Lex] Viecore FSD, Eatontown, NJ USA.
   [Regli, W.; Nguyen, D.; McCurdy, M.; Millar, D.; Simmons, I.; Cannon, C.; Kopena, J.] Drexel Univ, Appl Commun & Informat Networking Inst, Philadelphia, PA USA.
   [Patwardhan, A.; Tassone, G.] Cougaar Software, Dunn Loring, VA USA.
   [Lindquist, J.; Jewell, G.] Raytheon, Waltham, MA USA.
   [Forkenbrock, R.; Nicholson, M.] SAIC, Mclean, VA USA.
   [Koss, F.; Wray, R.] Soar Technol, Ann Arbor, MI USA.
   [Bradshaw, J.; Lott, J.] Inst Human Machine Cognit, Pensacola, FL USA.
RP Mayk, I (reprint author), CERDEC, RDECOM, C2D, Aberdeen Proving Ground, MD 21005 USA.
NR 16
TC 2
Z9 2
U1 0
U2 4
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1568
EP 1573
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500263
ER

PT J
AU Chen, T
   Cichocki, A
   Eswaran, S
   Kaui, V
   Lin, YJ
   Samtani, S
   Shurl, D
   Bowcock, J
AF Chen, Ta
   Cichocki, Andrzej
   Eswaran, Sharanya
   Kaui, Vikram
   Lin, Yow-Jian
   Samtani, Sunil
   Shurl, David
   Bowcock, Jeff
GP IEEE
TI Advances in Content Transformation in Heterogeneous Tactical Wireless
   Networks
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE filtering; intent sensing; natural language processing; content based
   routing; policy management; multiple gateways
AB Content transformation is a viable technique for managing information delivered to tactical MANET nodes interconnected via a quasi-static network (QSN), especially during the period when available bandwidth is limited due to mobility, terrain, weather, jamming, etc. In previous work, we proposed Heterogeneous Intelligent Filtering (HIF) in multi-domain heterogeneous networks, for intelligent active data filtering and transformation to match network capacity and end-user capability. The need for data filtering was determined solely based on network conditions, for example, bandwidth available to the destined MANET nodes at the time. In this work(2), we report on enhancing HIF to automatically sense and take into consideration end-user intent and interests in data filtering. We illustrate how a speech-to-text engine can be used to deliver text in place of original speech, and save bandwidth usage, when a circumstance (e.g., a noisy environment) warrants such filtering. We also present several topic-of-interest- and location-based filtering features, and describe how one can combine them to create user intent filtering rules for selectively delivering and/or rerouting messages of interests in applications such as C2MINCS and XMPP-based Chat. We then describe additional HIF extensions and enhancements for deployment and operation support, including the use of HIF as a data dissemination service for individual applications, a distributed primary-backup HIF server mechanism for fault tolerance, and a policy management framework for managing the configuration of HIF components.
C1 [Chen, Ta; Cichocki, Andrzej; Eswaran, Sharanya; Kaui, Vikram; Lin, Yow-Jian; Samtani, Sunil; Shurl, David] Telcordia Technol Inc, Appl Res, Piscataway, NJ 08854 USA.
   [Bowcock, Jeff] US Army, CERDEC, Aberdeen Proving Ground, MD 21005 USA.
RP Shurl, D (reprint author), Telcordia Technol Inc, Appl Res, Piscataway, NJ 08854 USA.
EM dshur@research.telcordia.com
NR 9
TC 1
Z9 1
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1574
EP 1579
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500264
ER

PT J
AU Poylisher, A
   Sultan, F
   Ghosh, A
   Li, SW
   Chiang, CJ
   Chadha, R
   Moeltner, K
   Jakubowski, K
AF Poylisher, Alex
   Sultan, Florin
   Ghosh, Abhrajit
   Li, Shi-wei
   Chiang, C. Jason
   Chadha, Ritu
   Moeltner, Kimberly
   Jakubowski, Kim
GP IEEE
TI QAM: A Comprehensive QoS-aware Middleware Suite for Tactical
   Communications
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
AB QAM (QoS-aware Adaptive Middleware) is a software framework for developing distributed applications intended to operate in tactical MANET environments(1). Developing distributed applications for tactical MANETs is challenging due to the dynamic network capacity and competing priorities across multiple applications. QAM allows a developer to focus on the processing aspects of the application by abstracting out the details of bandwidth constrained communication and relative application priorities. QAM enforces sharing of dynamic network capacity by application flows by allocating bandwidth use in proportion to application priority.
   QAM consists of: (i) an Adaptable Transport layer in which the rate of a flow can be tuned dynamically by an external controller, (ii) a measurement-based Admission Control function that enables applications to seek admission for network flows and receive a starting rate, and (iii) a measurement-based Quality Adjustment function that adjusts the rates of admitted flows based on their priorities and optionally provides rate feedback to adaptive applications.
   Adaptable Transport supports both unreliable and reliable point-to-point modes. On top, QAM builds a distribution layer for point-to-multipoint communication. To enforce priority-aware resource allocation in such communication, QAM incorporates Group Admission Control and Group Quality Adjustment functions.
   QAM provides a Legacy Proxy facility which interacts with Admission Control and Quality Adjustment on behalf of the legacy applications, to allow them to benefit from QAM capabilities and co-exist with QAM applications.
C1 [Poylisher, Alex; Sultan, Florin; Ghosh, Abhrajit; Li, Shi-wei; Chiang, C. Jason; Chadha, Ritu] Telcordia Technol Inc, Adv Technol Solut, Piscataway, NJ 08854 USA.
   [Moeltner, Kimberly; Jakubowski, Kim] US Army, CERDEC, Commun Networks & Networking Div, Aberdeen Proving Ground, MD USA.
RP Poylisher, A (reprint author), Telcordia Technol Inc, Adv Technol Solut, Piscataway, NJ 08854 USA.
FU U.S. Army Communications Electronics Research and Development
   Engineering Center (CERDEC) [W15P7T-08-C-P213]
FX 1The research reported in this document was performed in connection with
   contract number W15P7T-08-C-P213 with the U.S. Army Communications
   Electronics Research and Development Engineering Center (CERDEC).
NR 10
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1586
EP 1591
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500266
ER

PT J
AU Tauil, M
   Shallcross, D
   Kant, L
   Graff, C
   Patel, M
AF Tauil, M.
   Shallcross, D.
   Kant, L.
   Graff, C.
   Patel, M.
GP IEEE
TI Spectrum Allocation in C-NEDAT: a Tool to Automate MANET Design and
   Opportunistically Adapt Network Spectrum Use
SO 2011 - MILCOM 2011 MILITARY COMMUNICATIONS CONFERENCE
LA English
DT Proceedings Paper
CT Military Communications Conference (MILCOM)
CY NOV 07-10, 2011
CL Baltimore, MD
DE Primary Spectrum Assignment; Secondary/Dynamic Spectrum Assignment;
   Cognitive Network Design
AB The advancements in cognitive radios coupled with the ever increasing demand for spectrum have propelled research into dynamic and adaptive spectrum management techniques. More specifically, the need to support a wide variety of network centric warfare(NCW) applications combined with the dearth in 'available' spectrum underscores the need for opportunistic spectrum use, whereby idle spectrum can be 'borrowed' used opportunistically by applications that need it. To this end, Telcordia and CERDEC have developed a cognitive network design tool called C-NEDAT to provide for a systematic method to design NCW-like networks. An important aspect that we address with C-NEDAT is spectrum assignment in multiple time scales.
C1 [Tauil, M.; Shallcross, D.; Kant, L.] Telcordia Technol Inc, Appl Res, Piscataway, NJ 08854 USA.
   [Graff, C.] US Army, CERDEC, Ft Monmouth, NJ USA.
   [Patel, M.] US Army, CERDEC, Aberdeen, MD USA.
RP Tauil, M (reprint author), Telcordia Technol Inc, Appl Res, Piscataway, NJ 08854 USA.
FU U.S. Army CERDEC [DAAD-19-01-C-0062]
FX This work was sponsored by U.S. Army CERDEC under contract
   DAAD-19-01-C-0062.
NR 7
TC 0
Z9 0
U1 0
U2 0
PU IEEE
PI NEW YORK
PA 345 E 47TH ST, NEW YORK, NY 10017 USA
BN 978-1-4673-0081-0
PY 2011
BP 1702
EP 1707
PG 6
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA BYT03
UT WOS:000300083500285
ER

EF