FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Blaylock, JM Decker, CF AF Blaylock, Jason M. Decker, Catherine F. TI Common Infections in the Collegiate Athlete SO DM DISEASE-A-MONTH LA English DT Article ID EPSTEIN-BARR-VIRUS; ACQUIRED BACTERIAL-MENINGITIS; SCHOOL FOOTBALL TEAM; ASEPTIC-MENINGITIS; CEREBROSPINAL-FLUID; PROGNOSTIC-FACTORS; MONONUCLEOSIS; ADULTS; OUTBREAK; DISEASE C1 [Blaylock, Jason M.] Walter Reed Army Med Ctr, Infect Dis Serv, Dept Internal Med, Washington, DC 20307 USA. [Decker, Catherine F.] Uniformed Serv Univ Hlth Sci, Div Infect Dis, Dept Internal Med, Natl Naval Med Ctr, Bethesda, MD 20814 USA. RP Blaylock, JM (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, Dept Internal Med, Washington, DC 20307 USA. NR 55 TC 0 Z9 0 U1 1 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0011-5029 J9 DM-DIS MON JI DM-Dis.-a-Mon. PD JUL PY 2010 VL 56 IS 7 BP 422 EP 435 DI 10.1016/j.disamonth.2010.05.003 PG 14 WC Medicine, General & Internal SC General & Internal Medicine GA 629QY UT WOS:000280216000005 PM 20621216 ER PT J AU McDonough, JH McMonagle, JD Shih, TM AF McDonough, John H. McMonagle, Joseph D. Shih, Tsung-Ming TI Time-dependent reduction in the anticonvulsant effectiveness of diazepam against soman-induced seizures in guinea pigs SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article DE Nerve agent; soman; seizure; diazepam; benzodiazepine; anticonvulsant ID AGENT-INDUCED SEIZURES; STATUS EPILEPTICUS; INDUCED NEUROPATHOLOGY; RESPIRATORY-FAILURE; EFFICACY; AVIZAFONE; BENZODIAZEPINES; PILOCARPINE; ATROPINE; RATS AB Near-lethal exposure to nerve agents produces prolonged epileptiform seizures requiring the administration of benzodiazepine anticonvulsant drugs, such as diazepam. Clinically, benzodiazepines are reported to lose anticonvulsant effectiveness the greater the delay between seizure onset and benzodiazepine treatment. This time-dependent diminished effectiveness of diazepam was tested in the present study. Seizures elicited by the nerve agent, soman, were produced in guinea pigs instrumented to record brain electrocorticographic (ECoG) activity. Different groups of animals were administered 10 mg/kg, intramuscularly, of diazepam at 5, 40, 60, 80, or 160 minutes after the onset of seizure activity. There was a progressive loss in the anticonvulsant efficacy of diazepam as the treatment was delayed after seizure onset, but no differences in the time for diazepam to stop seizures. The results show a diminished ability of diazepam to stop nerve-agent induced seizures the longer treatment is delayed. C1 [McDonough, John H.; McMonagle, Joseph D.; Shih, Tsung-Ming] USA, Med Res Inst Chem Def, Pharmacol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP McDonough, JH (reprint author), USA, Med Res Inst Chem Def, Pharmacol Branch, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM john.mcdonough1@us.army.mil FU Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [I.30004_04_RC_C] FX This research was supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division: Proposal I.30004_04_RC_C. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. NR 18 TC 16 Z9 17 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PD JUL PY 2010 VL 33 IS 3 BP 279 EP 283 DI 10.3109/01480540903483417 PG 5 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA 633CP UT WOS:000280477400008 PM 20429808 ER PT J AU Lotufo, GR Blackburn, WM Gibson, AB AF Lotufo, Guilherme R. Blackburn, William M. Gibson, Alfreda B. TI Toxicity of trinitrotoluene to sheepshead minnows in water exposures SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Explosives; TNT; Toxicity; Bioaccumulation; Critical body residue; Sheepshead minnow; Cyprinodon variegatus ID CATFISH ICTALURUS-PUNCTATUS; EARTHWORM EISENIA-ANDREI; EXPLOSIVE COMPOUNDS; 2,4,6-TRINITROTOLUENE TNT; MYTILUS-GALLOPROVINCIALIS; DEGRADATION-PRODUCTS; AQUATIC ORGANISMS; HYALELLA-AZTECA; FATHEAD MINNOW; MARINE MUSSEL AB Lethal effects of trinitrotoluene (TNT) to juvenile sheepshead minnows (JSHM) (Cyprinodon variegatus) were assessed in ten-day water exposures. Ten-day median lethal concentrations (LC50s) were 2.3 and 2.5 mg L(-1), the 10-d median lethal residue value (LR50) was 26.1 mu mol kg(-1) wet weight (ww), and bioconcentration factors (BCFs) ranged from 0.7 to 2.4 L kg(-1). The lethal effects of TNT and its transformation products 2-aminodinitrotoluene (2-ADNT), 2,4-diaminonitrotoluene (2,4-DANT) and trinitrobenzene (TNB) to JSHM were compared in 5-d static-renewal exposures. Nitroreduction decreased the toxicity of TNT to SHM, as the 5-d LC50 for 2-ADNT was 8.6 mg L(-1) and the lowest lethal concentration of 2,4-DANT was 50.3 mg L(-1). TNB (5-d LC50=1.2 mg L(-1)) was more toxic than TNT to SHM. The 5-d LR50s were 4.3 mg kg(-1) ww (20.4 mu mol kg(-1)) for SumTNT (TNT exposure) and 54.2 mg kg(-1) ww (275.3 mu mol kg(-1)) for 2-ADNT and significant mortality occurred at 47.4 mg kg(-1) ww (283.6 mu mol kg(-1)). The range of BCF values was from 1.8 to 2.4, 5.6 to 8.0, and 0.6 to 0.9 L kg(-1) for TNT, 2-ADNT, and 2,4-DANT, respectively. Published by Elsevier Inc. C1 [Lotufo, Guilherme R.; Blackburn, William M.; Gibson, Alfreda B.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Lotufo, GR (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU U.S. Navy; U.S. Army FX The U.S. Navy's Environmental Sustainability Development to Integration Program and the Environmental Quality Technology Research Program of the U.S. Army supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N456) and the Chief of Engineers. The authors thank Daniel Farrar for high performance liquid chromatography analyses. We are grateful to Gunther Rosen, Robert George, Allan Kennedy, M. John Cullinane, and Elizabeth Ferguson for their review of this manuscript. NR 44 TC 2 Z9 2 U1 1 U2 6 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD JUL PY 2010 VL 73 IS 5 BP 718 EP 726 DI 10.1016/j.ecoenv.2010.02.007 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 621YU UT WOS:000279623800004 PM 20219247 ER PT J AU Geisbert, TW Hensley, LE Geisbert, JB Leung, A Johnson, JC Grolla, A Feldmann, H AF Geisbert, Thomas W. Hensley, Lisa E. Geisbert, Joan B. Leung, Anders Johnson, Joshua C. Grolla, Allen Feldmann, Heinz TI Postexposure Treatment of Marburg Virus Infection SO EMERGING INFECTIOUS DISEASES LA English DT Article ID EBOLA HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; PROTECTION; VECTORS AB Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus-based vaccine is administered 20-30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection. C1 [Geisbert, Thomas W.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. [Hensley, Lisa E.; Johnson, Joshua C.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Leung, Anders; Grolla, Allen] Publ Hlth Agcy Canada, Winnipeg, MB, Canada. [Feldmann, Heinz] NIH, Hamilton, MT USA. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, 620 Albany St,Rm 401B, Boston, MA 02118 USA. EM geisbert@bu.edu OI Johnson, Joshua/0000-0002-5677-3841 FU Defense Threat Reduction Agency; Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, National Institutes of Health; National Microbiology Laboratory of the Public Health Agency of Canada FX Funding was provided by the Defense Threat Reduction Agency, the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the National Microbiology Laboratory of the Public Health Agency of Canada. NR 14 TC 34 Z9 36 U1 0 U2 2 PU CENTERS DISEASE CONTROL PI ATLANTA PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUL PY 2010 VL 16 IS 7 BP 1119 EP 1122 DI 10.3201/eid1607.100159 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 620TG UT WOS:000279522200011 PM 20587184 ER PT J AU Abel, MT Cobb, GP Presley, SM Ray, GL Rainwater, TR Austin, GP Cox, SB Anderson, TA Leftwich, BD Kendall, RJ Suedel, BC AF Abel, Michael T. Cobb, George P. Presley, Steven M. Ray, Gary L. Rainwater, Thomas R. Austin, Galen P. Cox, Stephen B. Anderson, Todd A. Leftwich, Blair D. Kendall, Ronald J. Suedel, Burton C. TI LEAD DISTRIBUTIONS AND RISKS IN NEW ORLEANS FOLLOWING HURRICANES KATRINA AND RITA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article; Proceedings Paper CT 29th Annual Meeting of the Society-of-Environmental-Toxicology-and-Chemistry-North-America CY NOV 16-20, 2008 CL Tampa, FL SP Soc Environm Toxicol & Chem N Amer DE Metal accumulation; Metal bioavailability; Hurricane ID LOUISIANA; EXPOSURE; SOILS; SEDIMENTS; CHILDREN; USA AB During the last four years, significant effort has been devoted to understanding the effects that Hurricanes Katrina and Rita had on contaminant distribution and redistribution in New Orleans, Louisiana, USA, and the surrounding Gulf Coast area. Elevated concentrations were found for inorganic contaminants (including As, Fe, Pb, and V), several organic pollutants (polycyclic aromatic hydrocarbons, pesticides, and volatiles) and high concentration of bioaerosols, particularly Aeromonas and Vibrio. Data from different research groups confirm that some contaminant concentrations are elevated, that existing concentrations are similar to historical data, and that contaminants such as Ph and As may pose human health risks. Two data sets have been compiled in this article to serve as the foundation for preliminary risk assessments within greater New Orleans. Research from the present study suggests that children in highly contaminated areas of New Orleans may experience Pb exposure from soil ranging from 1.37 mu g/d to 102 mu g/d. These data are critical in the evaluation of children's health. Environ. Toxicol. Chem. 2010;29:1429-1437. (C) 2010 SETAC C1 [Abel, Michael T.; Cobb, George P.; Presley, Steven M.; Rainwater, Thomas R.; Austin, Galen P.; Cox, Stephen B.; Anderson, Todd A.; Kendall, Ronald J.] Texas Tech Univ, Dept Environm Toxicol, Inst Environm & Human Hlth, Lubbock, TX 79409 USA. [Abel, Michael T.; Leftwich, Blair D.] TraceAnalysis Inc, Lubbock, TX 79424 USA. [Ray, Gary L.; Suedel, Burton C.] USA, Corps Engineers, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Cobb, GP (reprint author), Texas Tech Univ, Dept Environm Toxicol, Inst Environm & Human Hlth, Box 41163, Lubbock, TX 79409 USA. EM george.cobb@tiehh.ttu.edu RI Cox, Stephen/A-5037-2010 NR 46 TC 5 Z9 5 U1 0 U2 12 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2010 VL 29 IS 7 BP 1429 EP 1437 DI 10.1002/etc.205 PG 9 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 619VQ UT WOS:000279458800005 PM 20821590 ER PT J AU Coleman, JG Johnson, DR Stanley, JK Bednar, AJ Weiss, CA Boyd, RE Steevens, JA AF Coleman, Jessica G. Johnson, David R. Stanley, Jacob K. Bednar, Anthony J. Weiss, Charles A., Jr. Boyd, Robert E. Steevens, Jeffery A. TI ASSESSING THE FATE AND EFFECTS OF NANO ALUMINUM OXIDE IN THE TERRESTRIAL EARTHWORM, EISENIA FETIDA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Nano; Aluminum oxide; Soil; Eisenia fetida; Bioaccumulation ID CONTAMINATED SOILS; CARBON NANOTUBES; TOXICITY; NANOPARTICLES; NANOMATERIALS; BEHAVIOR; GROWTH; BIOACCUMULATION; PHYTOTOXICITY; TRANSPORT AB Nano-sized aluminum is currently being used by the military and commercial industries in many applications including coatings, thermites, and propellants. Due to the potential for wide dispersal in soil systems, we chose to investigate the fate and effects of nano-sized aluminum oxide (Al(2)O(3)), the oxidized form of nano aluminum, in a terrestrial organism. The toxicity and bioaccumulation potential of micron-sized (50-200 mu m, nominal) and nano-sized (11 nm, nominal) Al(2)O(3) was comparatively assessed through acute and subchronic bioassays using the terrestrial earthworm, Eisenia fetida. Subchronic (28-d) studies were performed exposing E. fetida to nano- and micron-sized Al(2)O(3)-spiked soils to assess the effects of long-term exposure. No mortality occurred in subchronic exposures, although reproduction decreased at >= 3,000 mg/kg nano-sized Al(2)O(3) treatments, with higher aluminum body burdens observed at 100 and 300 mg/kg; no reproductive effects were observed in the micron-sized Al(2)O(3) treatments. In addition to toxicity and bioaccumulation bioassays, an acute (48-h) behavioral bioassay was conducted utilizing a soil avoidance wheel in which E. fetida were given a choice of habitat between control, nano-, or micron-sized Al(2)O(3) amended soils. In the soil avoidance bioassays. E. fetida exhibited avoidance behavior toward the highest concentrations of micron- and nano-sized Al(2)O(3) (>5,000 mg/kg) relative to control soils. Results of the present study indicate that nano-sized Al(2)O(3) may impact reproduction and behavior of E. fetida, although at high levels unlikely to be found in the environment. Environ. Toxicol. Chem. 2010;29:1575-1580. (C) 2010 SETAC C1 [Coleman, Jessica G.; Johnson, David R.; Stanley, Jacob K.; Bednar, Anthony J.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Weiss, Charles A., Jr.] USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Boyd, Robert E.] SpecPro, Vicksburg, MS 39180 USA. RP Coleman, JG (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jessica.g.coleman@usace.army.mil NR 29 TC 40 Z9 44 U1 2 U2 38 PU SETAC PRESS PI PENSACOLA PA 1010 N 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2010 VL 29 IS 7 BP 1575 EP 1580 DI 10.1002/etc.196 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 619VQ UT WOS:000279458800023 PM 20821608 ER PT J AU Urso, ML Szelenyi, ER Warren, GL Barnes, BR AF Urso, Maria L. Szelenyi, Eric R. Warren, Gordon L. Barnes, Brian R. TI Matrix metalloprotease-3 and tissue inhibitor of metalloprotease-1 mRNA and protein levels are altered in response to traumatic skeletal muscle injury SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE Freeze injury; Muscle remodeling; Gene expression; MMP-3; TIMP-1 ID NECROSIS-FACTOR-ALPHA; SATELLITE CELLS; GENE-EXPRESSION; IV COLLAGEN; IN-VITRO; FIBROBLASTS; ACTIVATION; EXERCISE; GROWTH; STROMELYSIN-1 AB The purpose of this study was to characterize the time course of matrix metalloprotease-3 (MMP-3) and tissue inhibitor of metalloprotease-1 (TIMP-1) expression in mouse tibialis anterior (TA) muscle post-injury. Mice were anesthetized, the TA muscle exposed, and injury induced by applying a cold steel probe (-79A degrees C) to the muscle for 10 s. Muscle was collected from uninjured and injured legs at 3, 10, 24, 48, and 72 h post-injury. qRT-PCR, immunoblotting, and immunohistochemistry were used to quantify/localize MMP-3 and TIMP-1. MMP-3 transcripts increased 19- and 12-fold, 10 and 24 h post-injury (p < 0.01), respectively. TIMP-1 transcript levels increased 9-, 34-, and 60-fold, 10, 24, and 48 h post-injury (p = 0.01), respectively, with a subsequent decrease 72 h post-injury (p < 0.01). Protein levels of the pro-form of MMP-3 increased within 3 h post-injury and remained elevated (p < 0.05). Active MMP-3 decreased over time, reaching a 72% decrease 72 h post-injury (p < 0.05). TIMP-1 protein decreased 75% within 3 h post-injury, returning to baseline by 72 h post-injury. In response to injury, injured skeletal muscle preferentially produces increased levels of the latent form of the MMP-3 protein with a concomitant decrease in the active form, and a significant decrease in TIMP-1 expression. The altered pattern of MMP-3/TIMP-1 expression may be due to alterations in post-transcriptional mechanisms that are responsible for specific regulation of the MMP-3/TIMP-1 system. These data suggest that there is a disproportionate regulation of the MMP-3/TIMP-1 system following traumatic injury and this response may contribute to impaired extracellular matrix remodeling. C1 [Urso, Maria L.; Szelenyi, Eric R.; Barnes, Brian R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Warren, Gordon L.] Georgia State Univ, Div Phys Therapy, Atlanta, GA 30302 USA. RP Urso, ML (reprint author), USA, Environm Med Res Inst, 42 Kansas St,Bldg 42, Natick, MA 01760 USA. EM maria.urso@us.army.mil RI Warren, Gordon/A-9794-2008; OI Warren, Gordon/0000-0002-7073-8524; Urso, Maria/0000-0001-8906-4673 NR 35 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD JUL PY 2010 VL 109 IS 5 BP 963 EP 972 DI 10.1007/s00421-010-1435-5 PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 616FU UT WOS:000279195200019 PM 20349081 ER PT J AU Ricker, JM Mathis, DA Arnold, HL AF Ricker, Jonathan M. Mathis, Derek A. Arnold, Hays L. TI An interesting case of iron deficiency anemia SO GASTROINTESTINAL ENDOSCOPY LA English DT Editorial Material C1 [Ricker, Jonathan M.] Wilford Hall USAF Med Ctr, Dept Gastroenterol & Hepatol, Lackland AFB, TX 78236 USA. [Mathis, Derek A.] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. [Arnold, Hays L.] Brooke Army Med Ctr, Dept Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Ricker, JM (reprint author), Wilford Hall USAF Med Ctr, Dept Gastroenterol & Hepatol, Lackland AFB, TX 78236 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUL PY 2010 VL 72 IS 1 BP 189 EP 189 DI 10.1016/j.gie.2010.01.038 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 622TD UT WOS:000279687600035 PM 20620279 ER PT J AU Arcone, S Finnegan, D Boitnott, G AF Arcone, Steven Finnegan, David Boitnott, Ginger TI GPR characterization of a lacustrine UXO site SO GEOPHYSICS LA English DT Article ID WATER-CONTENT; RADAR; SOIL; STRATIGRAPHY; RESONANCES; PROFILES; FIRN AB We used 135-MHz ground-penetrating-radar (GPR) reflection profiles to determine if high-explosive (HE) depth bombs were possibly detonated within a small New England lake formerly used as a bombing range, as well as the depths and distribution of inert and possibly unexploded ordnance (UXO) within the subbottom sediments. Maximum water depth was 8.6 m. The primary munitions were unarmed practice bombs, but terrestrial fragments from HE depth bombs led us to seek stratigraphic obliteration and distortion as evidence of their use. The low water conductivity and quartz-rich sediments provided more than 8 m of subbottom penetration beneath slope and shelf sediments. The high permittivities of the water and subbottom sediments provided good antenna directivity, excellent 2D migrations, multicentimeter vertical resolution, and a unique pulse waveform signature for metal objects. Our line profiles revealed hundreds of subbottom diffractions, which implied an areal distribution of thousands of suspicious objects. Most lay beneath the central basin, but many resided beneath the slopes and shelves as well. Supplementary profiles of a nearby pristine lake and of controlled munitions, a side-scan sonar bottom survey, and time-domain reflectometry dielectric measurements of sediment samples corroborated our findings of natural stratigraphy, a unique metallic diffraction phase signature, the existence of many nonmetallic objects including logs, and subbottom relative permittivities ranging from 28 to 76. The intact natural lacustrine strata, including deltaic foresets and bottom sets, faults, and conformable and unconformable horizons, suggest that live bombs likely did not detonate in the lake. The only stratigraphic disturbances we found were apparent perforations beneath about 1 m of water, within which diffractions of metallic origin Originated. The dielectric results and the prominent slope strata over the deepest horizons led us to conclude that the exceptional subbottom penetration existed under predominantly sandy sediments. C1 [Arcone, Steven; Finnegan, David; Boitnott, Ginger] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr ERDC, Hanover, NH 03755 USA. [Arcone, Steven] Univ Connecticut, Storrs, CT 06269 USA. RP Arcone, S (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr ERDC, 72 Lyme Rd, Hanover, NH 03755 USA. EM steven.a.arcone@usace.army.mil; david.finnegan@usace.army.mil; ginger.e.boitnott@usace.army.mil FU U.S. Army Strategic Environmental Research and Development [UX-1440]; New Boston Air Force Station, New Boston, New Hampshire FX This work was supported by the U.S. Army Strategic Environmental Research and Development Program, Project UX-1440, and contracts from the New Boston Air Force Station, New Boston, New Hampshire. We thank Anne Andrews, Program Manager for Munitions Management, during this project for her support; Jeffrey Daniels of Ohio State University; Jeffrey Marqusee and Bradley Smith of the Strategic Environmental Research and Development Program (SERDP) office for their helpful direction; Timothy Brecheen, Major Tracey Swope, and Jeffrey Oja of the New Boston Air Station, New Boston, New Hampshire; and Gretchen Tabano of Shaw Environmental Associates, Baltimore, Maryland for their assistance. Garry Kozak conducted and processed the side-scan sonar survey, and Sampath Iyengar of TM Technologies performed the sediment XRD and grain-size analysis. NR 28 TC 4 Z9 4 U1 3 U2 6 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 EI 1942-2156 J9 GEOPHYSICS JI Geophysics PD JUL-AUG PY 2010 VL 75 IS 4 BP WA221 EP WA239 DI 10.1190/1.3467782 PG 19 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 676KN UT WOS:000283910000055 ER PT J AU Scheinberg, P Marte, M Nunez, O Young, NS AF Scheinberg, Phillip Marte, Michael Nunez, Olga Young, Neal S. TI Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine SO HAEMATOLOGICA-THE HEMATOLOGY JOURNAL LA English DT Article DE paroxysmal nocturnal hemoglobinuria; severe aplastic anemia ID BONE-MARROW FAILURE; COMPLEMENT INHIBITOR ECULIZUMAB; ANTITHYMOCYTE GLOBULIN; IMMUNOSUPPRESSIVE THERAPY; PIG-A; CELLS; CORTICOSTEROIDS AB Background Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and are present in about 40-50% of patients with severe aplastic anemia. Flow cytometry has allowed for sensitive and precise measurement of glycosylphosphatidylinositol-anchor protein-deficient red blood cells and neutrophils in severe aplastic anemia. Design and Methods We conducted a retrospective analysis of paroxysmal nocturnal hemoglobinuria clones measured by flow cytometry in 207 consecutive severe aplastic anemia patients who received immunosuppressive therapy with a horse anti-thymocyte globulin plus cyclosporine regimen from 2000 to 2008. Results The presence of a glycosylphosphatidylinositol-anchor protein-deficient clone was detected in 83 (40%) patients pre-treatment, and the median clone size was 9.7% (interquartile range 3.5-29). In patients without a detectable clone pre-treatment, the appearance of a clone after immunosuppressive therapy was infrequent, and in most with a clone pre-treatment, clone size often decreased after immunosuppressive therapy. However, in 30 patients, an increase in clone size was observed after immunosuppressive therapy. The majority of patients with a paroxysmal nocturnal hemoglobinuria clone detected after immunosuppressive therapy did not have an elevated lactate dehydrogenase, nor did they experience hemolysis or thrombosis, and they did not require specific interventions with anticoagulation and/or eculizumab. Of the 7 patients who did require therapy for clinical paroxysmal nocturnal hemoglobinuria symptoms and signs, all had an elevated lactate dehydrogenase and a clone size greater than 50%. In all, 18 (8.6%) patients had a clone greater than 50% at any given time of sampling. Conclusions The presence of a paroxysmal nocturnal hemoglobinuria clone in severe aplastic anemia is associated with low morbidity and mortality, and specific measures to address clinical paroxysmal nocturnal hemoglobinuria are seldom required. C1 [Scheinberg, Phillip; Nunez, Olga; Young, Neal S.] NHLBI, Hematol Branch, NIH, Bethesda, MD 20892 USA. [Marte, Michael] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA. RP Scheinberg, P (reprint author), NHLBI, Hematol Branch, NIH, 10 Ctr Dr,Bldg 10 CRC,Rm 3-5140,MSC 1202, Bethesda, MD 20892 USA. EM scheinbp@mail.nih.gov OI Scheinberg, Phillip/0000-0002-9047-4538 FU NIH; National Heart, Lung and Blood Institute FX Funding: this research was supported by the Intramural Research Program of the NIH, National Heart, Lung and Blood Institute. NR 20 TC 28 Z9 37 U1 0 U2 1 PU FERRATA STORTI FOUNDATION PI PAVIA PA VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY SN 0390-6078 J9 HAEMATOL-HEMATOL J JI Haematol-Hematol. J. PD JUL PY 2010 VL 95 IS 7 BP 1075 EP 1080 DI 10.3324/haematol.2009.017889 PG 6 WC Hematology SC Hematology GA 624WT UT WOS:000279853500007 PM 20595102 ER PT J AU Jarvis, JC Moore, KA AF Jarvis, Jessie C. Moore, Kenneth A. TI The role of seedlings and seed bank viability in the recovery of Chesapeake Bay, USA, Zostera marina populations following a large-scale decline SO HYDROBIOLOGIA LA English DT Article DE Zostera marina; Decline; Sexual reproduction; Seedling; Seed-bank ID L EELGRASS; ENVIRONMENTAL-FACTORS; GERMINATION; GROWTH; RECOLONIZATION; NETHERLANDS; SEAGRASSES; PREDATION; ABUNDANCE; DORMANCY AB The objective of this study was to quantify the spatial and temporal recolonization characteristics of Zostera marina beds in the lower Chesapeake Bay following large scale declines in the late summer of 2005. Transects were established and monitored monthly for changes in eelgrass abundance at three sites (two downriver, one upriver) in the York River from April-October 2006 and 2007. Measurements included percent bottom cover, above ground biomass, shoot density, shoot origin (seedling or vegetative), seed bank abundance and seed viability. During 2006, the eelgrass beds at all sites recovered with seedlings providing the largest proportion of the total shoot abundance. This trend shifted in 2007 and surviving vegetative shoots were the dominant component of shoot standing crop. A second consecutive decline related to low light conditions occurred during the summer of 2006 in the upriver site and recovery there was minimal in 2007. These results highlight that after a single die off event, seed germination with subsequent seedling growth is the principal method for revegetation in lower Chesapeake Bay Z. marina beds. However, no viable seeds remain in the seed bank during this first year of recovery and shoots produced by the seedling growth do not flower and produce seeds until their second year of growth. Therefore the seed-bank density is low and is not immediately replenished. This suggests that the resiliency of perennial Chesapeake Bay Z. marina populations to repeated disturbances is restricted and repeated annual stress may result in much longer term bed loss. C1 [Jarvis, Jessie C.; Moore, Kenneth A.] Coll William & Mary, Virginia Inst Marine Sci, Gloucester Point, VA 23062 USA. [Jarvis, Jessie C.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Jarvis, JC (reprint author), Coll William & Mary, Virginia Inst Marine Sci, POB 1346, Gloucester Point, VA 23062 USA. EM jessiecjarvis@usace.army.mil RI Jarvis, Jessie/M-5929-2013 OI Jarvis, Jessie/0000-0001-8467-0287 NR 43 TC 28 Z9 29 U1 5 U2 21 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD JUL PY 2010 VL 649 IS 1 BP 55 EP 68 DI 10.1007/s10750-010-0258-z PG 14 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA 596XV UT WOS:000277720100006 ER PT J AU Pace, T AF Pace, Teresa TI Untitled SO IEEE AEROSPACE AND ELECTRONIC SYSTEMS MAGAZINE LA English DT Editorial Material C1 USA, RDECOM, Orlando, FL 32826 USA. RP Pace, T (reprint author), USA, RDECOM, 3280 Progress Dr,Off 515, Orlando, FL 32826 USA. EM teresapace@ieee.org NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-8985 J9 IEEE AERO EL SYS MAG JI IEEE Aerosp. Electron. Syst. Mag. PD JUL PY 2010 VL 25 IS 7 BP 3 EP 3 PN 1 PG 1 WC Engineering, Aerospace; Engineering, Electrical & Electronic SC Engineering GA 669UM UT WOS:000283375700001 ER PT J AU Lance, BJ Marsella, SC AF Lance, Brent J. Marsella, Stacy C. TI The Expressive Gaze Model: Using Gaze to Express Emotion SO IEEE COMPUTER GRAPHICS AND APPLICATIONS LA English DT Article ID HEAD C1 [Lance, Brent J.] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Marsella, Stacy C.] Univ So Calif, Inst Creat Technol, Computat Emot Grp, Los Angeles, CA 90089 USA. RP Lance, BJ (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD USA. EM blance@ict.usc.edu; marsella@ict.usc.edu FU US Army Research Laboratory; US Army Research, Development, and Engineering Command FX We thank Bosco Tjan, Karen Liu, Skip Rizzo, W. Lewis Johnson, Mei Si, Sharon Carnicke, Marcus Thiebaux, Andrew Marshall, Jina Lee, and Tiffany Cole for their invaluable assistance in this research. This research was supported partly by an appointment to the US Army Research Laboratory Postdoctoral Fellowship Program administered by Oak Ridge Associated Universities through a contract with the US Army Research Laboratory, and partly by the US Army Research, Development, and Engineering Command. The content doesn't necessarily reflect the US government's position or policy, and no official endorsement should be inferred. NR 14 TC 6 Z9 6 U1 0 U2 3 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0272-1716 EI 1558-1756 J9 IEEE COMPUT GRAPH JI IEEE Comput. Graph. Appl. PD JUL-AUG PY 2010 VL 30 IS 4 BP 62 EP 73 DI 10.1109/MCG.2010.43 PG 12 WC Computer Science, Software Engineering SC Computer Science GA 615LZ UT WOS:000279138100009 PM 20650729 ER PT J AU Ward, WK Van Albert, S Bodo, M Pearce, F Gray, R Harlson, S Rebec, MV AF Ward, W. Kenneth Van Albert, Stephen Bodo, Michael Pearce, Frederick Gray, Rachael Harlson, Shane Rebec, Mihailo V. TI Design and Assessment of a Miniaturized Amperometric Oxygen Sensor in Rats and Pigs SO IEEE SENSORS JOURNAL LA English DT Article DE Amperometric; hemorrhage; oxygen; perfusion; sensor; trauma ID PROSPECTIVE RANDOMIZED-TRIAL; HEMORRHAGIC-SHOCK; TISSUE OXYGENATION; TRANSCUTANEOUS PRESSURE; PERIPHERAL PERFUSION; PULSE OXIMETRY; TENSION; ARRAY; RESUSCITATION; OPERATIONS AB The purpose of this project was to assess whether a novel, small diameter two-electrode oxygen sensor is capable of early detection of hemorrhage-induced hypoperfusion in rats and pigs. Hemorrhage is a very common cause of death after trauma and the degree of blood loss is difficult to gauge. In order to monitor blood volume, we developed a sensor designed to rapidly respond to changes in subcutaneous oxygen tension. The oxygen sensor included a platinum indicating electrode and a AgCl-based reference electrode. When tested in rats and pigs during controlled hemorrhage, the signals from these subcutaneously implanted sensors closely tracked the mean blood pressure and venous pO2. The sensor signals declined quickly during blood withdrawal and rose quickly in response to fluid resuscitation. Pulse rate was not a reliable indicator of blood loss. The signals of the oxygen sensors declined ( negative slope) during hemorrhage and rose ( positive slope) during resuscitation. In all cases, in both rats and pigs, slopes of less than -0.1 Torr/min indicated hemorrhage and slopes of more than 0.1 indicated resuscitation. Given the similarities of skin and subcutaneous tissue in pigs versus humans, devices like this may be useful for early detection of hemorrhage in humans. C1 [Ward, W. Kenneth; Gray, Rachael; Harlson, Shane; Rebec, Mihailo V.] ISense Dev Corp, Wilsonville, OR 97070 USA. [Van Albert, Stephen; Bodo, Michael; Pearce, Frederick] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Ward, WK (reprint author), Oregon Hlth & Sci Univ, Div Endocrinol, Portland, OR 97239 USA. EM wardk@ohsu.edu; steve.vanalbert@us.army.mil; michael.bodo@us.army.mil; frederick.pearce@osd.mil; rachael.gray@bayer.com; shane.harlson@bayer.com; rebec05@msn.com FU U.S. Department of Defense (Army) Telemedicine and Advanced Technology Research Center [W81XWH-07-1-0554] FX This work was supported in part by the U.S. Department of Defense (Army) Telemedicine and Advanced Technology Research Center under Contract W81XWH-07-1-0554. Disclaimer: Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the author, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. The associate editor coordinating the review of this paper and approving it for publication was Prof. Istvan Barsony. NR 34 TC 0 Z9 0 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD JUL PY 2010 VL 10 IS 7 BP 1259 EP 1265 DI 10.1109/JSEN.2009.2037017 PG 7 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 707TR UT WOS:000286311600001 ER PT J AU Sadjadi, FA Sullivan, A Gaunaurd, GC AF Sadjadi, Firooz A. Sullivan, Anders Gaunaurd, Guillermo C. TI Finding Underground Targets by Means of Change-Detection Methods in Huynen Spaces SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article ID SAR IMAGERY; SCATTERING AB A different and useful approach is presented for detecting new events in a scene, such as the presence or absence of landmines or perhaps the movement of people, vehicles, or structures. The approach rests on the radar examination of an area several times, once, before there are targets present, and the other (or others) after. The change detection algorithm notices if there are any changes after the first view. In the present approach the prospective target is represented, not in terms of three complex elements of a scattering matrix, but in terms of phenomenologically-based Huynen parameters. Each element of the Huynen parameter set conveys a different type of physical and geometrical attribute about the scatterers, thus the potential for significant false-alarm mitigation is increased. We provide results of the application of this approach on fully polarimetric signatures of simulated pairs of buried cylindrical targets. These results indicate the following. 1) Huynen parameters are more effective for change detection than the scattering matrix elements because of their ability to generate higher unambiguous autocorrelation peaks and fewer dominating cross-correlation curves. 2) A large number of symmetries are observed in the plots of the Huynen parameters for both one and two buried cylinders. These symmetries may eventually lead to further classification insights. 3) By using standard Prony methods, relevant resonance frequencies are extracted from the parameter plots, from which the height of either one of the cylinders is estimated. 4) The diameter of either cylinder can also be obtained by a simple procedure based on ray-tracing and time delays. Numerical calculations substantiate all the above assertions. C1 [Sadjadi, Firooz A.] Lockheed Martin Corp, Eagan, MN 55121 USA. [Sullivan, Anders; Gaunaurd, Guillermo C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Sadjadi, FA (reprint author), Lockheed Martin Corp, 3333 Pilot Knob Rd, Eagan, MN 55121 USA. EM firooz.a.sadjadi@Imco.com NR 31 TC 1 Z9 1 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JUL PY 2010 VL 46 IS 3 BP 1404 EP 1421 PG 18 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 664IZ UT WOS:000282954900032 ER PT J AU Wu, DR Courtney, CG Lance, BJ Narayanan, SS Dawson, ME Oie, KS Parsons, TD AF Wu, Dongrui Courtney, Christopher G. Lance, Brent J. Narayanan, Shrikanth S. Dawson, Michael E. Oie, Kelvin S. Parsons, Thomas D. TI Optimal Arousal Identification and Classification for Affective Computing Using Physiological Signals: Virtual Reality Stroop Task SO IEEE TRANSACTIONS ON AFFECTIVE COMPUTING LA English DT Article DE Affective computing; arousal classification; affect recognition; virtual reality; Stroop task; Yerkes-Dodson Law AB A closed-loop system that offers real-time assessment and manipulation of a user's affective and cognitive states is very useful in developing adaptive environments which respond in a rational and strategic fashion to real-time changes in user affect, cognition, and motivation. The goal is to progress the user from suboptimal cognitive and affective states toward an optimal state that enhances user performance. In order to achieve this, there is need for assessment of both 1) the optimal affective/cognitive state and 2) the observed user state. This paper presents approaches for assessing these two states. Arousal, an important dimension of affect, is focused upon because of its close relation to a user's cognitive performance, as indicated by the Yerkes-Dodson Law. Herein, we make use of a Virtual Reality Stroop Task (VRST) from the Virtual Reality Cognitive Performance Assessment Test (VRCPAT) to identify the optimal arousal level that can serve as the affective/cognitive state goal. Three stimuli presentations (with distinct arousal levels) in the VRST are selected. We demonstrate that when reaction time is used as the performance measure, one of the three stimuli presentations can elicit the optimal level of arousal for most subjects. Further, results suggest that high classification rates can be achieved when a support vector machine is used to classify the psychophysiological responses (skin conductance level, respiration, ECG, and EEG) in these three stimuli presentations into three arousal levels. This research reflects progress toward the implementation of a closed-loop affective computing system. C1 [Wu, Dongrui] GE Global Res, Ind Artificial Intelligence Lab, Niskayuna, NY 12309 USA. [Courtney, Christopher G.; Dawson, Michael E.] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA. [Courtney, Christopher G.] Univ So Calif, Inst Creat Technol, Los Angeles, CA 90089 USA. [Lance, Brent J.] US Army, Translat Neurosci Branch, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Narayanan, Shrikanth S.] Univ So Calif, Signal Anal & Interpretat Lab SAIL, Ming Hsieh Dept Elect Engn, Los Angeles, CA 90089 USA. [Oie, Kelvin S.] US Army RDECOM, Army Res Lab, RDRL HRS C, Aberdeen Proving Ground, MD 21005 USA. [Parsons, Thomas D.] Univ So Calif, Inst Creat Technol, Playa Vista, CA 90094 USA. RP Wu, DR (reprint author), GE Global Res, Ind Artificial Intelligence Lab, Niskayuna, NY 12309 USA. EM drwu09@gmail.com; courtney@ict.usc.edu; blance@ict.usc.edu; shri@sipi.usc.edu; mdsawson@usc.edu; kelvin.oie@us.army.mil; tparsons@ict.usc.edu NR 72 TC 29 Z9 29 U1 0 U2 16 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1949-3045 J9 IEEE T AFFECT COMPUT JI IEEE Trans. Affect. Comput. PD JUL-DEC PY 2010 VL 1 IS 2 BP 109 EP 118 DI 10.1109/T-AFFC.2010.12 PG 10 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics SC Computer Science GA V29OP UT WOS:000208758000004 ER PT J AU Duan, DL Qu, FZ Yang, LQ Swami, A Principe, JC AF Duan, Dongliang Qu, Fengzhong Yang, Liuqing Swami, Ananthram Principe, Jose C. TI Modulation Selection from a Battery Power Efficiency Perspective SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Battery power efficiency (BPE); pulse-based modulations; nonlinear battery model ID SENSOR NETWORKS AB In this paper, we compare the battery power efficiencies of various pulse-based modulations widely adopted for their low complexity. Taking into account circuit modules and battery imperfectness, we establish simple closed-form analytical formulas which can be used to conveniently determine the relative preference between arbitrary pulse-based modulation pairs in terms of their actual average battery energy consumption. C1 [Duan, Dongliang; Qu, Fengzhong; Yang, Liuqing; Principe, Jose C.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Yang, LQ (reprint author), Univ Florida, Dept Elect & Comp Engn, POB 116130, Gainesville, FL 32611 USA. EM ddl85@ufl.edu; jimqufz@ufl.edu; lqyang@ece.ufl.edu; a.swami@ieee.org; principe@cnel.ufl.edu RI Qu, Fengzhong/I-5189-2014 OI Qu, Fengzhong/0000-0003-2006-0951 FU Office of Naval Research [N00014-07-1-0868]; Army Research Office [W911NF-07-D-0001] FX This work is in part supported by Office of Naval Research under grant #N00014-07-1-0868, and Army Research Office under Contract #W911NF-07-D-0001. NR 11 TC 6 Z9 8 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 EI 1558-0857 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD JUL PY 2010 VL 58 IS 7 BP 1907 EP 1911 DI 10.1109/TCOMM.2010.07.080443 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 652GE UT WOS:000281990400004 ER PT J AU Valenti, MC Cheng, S Torrieri, D AF Valenti, Matthew C. Cheng, Shi Torrieri, Don TI Iterative Multisymbol Noncoherent Reception of Coded CPFSK SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article DE Continuous-phase modulation; noncoherent reception; channel capacity; block fading; channel coding ID CONTINUOUS-PHASE MODULATION; CPM AB A system involving the multisymbol noncoherent reception of coded continuous-phase frequency-shift keying is developed, optimized, and analyzed. Unlike coherent systems, the modulation index of the waveform does not need to be rational with a small denominator, and the oscillator only needs to be stable for the duration of a small block of symbols. The achievable performance over AWGN and Rayleigh block-fading channels is determined by computing the average mutual information, which is the capacity of a channel using the given modulation format and receiver architecture under the constraint of uniformly distributed input symbols. The code rate and modulation index are jointly optimized with respect to average mutual information under a bandwidth constraint. For binary and quaternary signaling, the information-theoretic results are corroborated by bit-error-rate curves generated using a standardized turbo code in conjunction with iterative demodulation and decoding. It is shown that, while more robust than a system with coherent reception, the proposed system offers superior energy efficiency compared with conventional single-symbol noncoherent reception. C1 [Valenti, Matthew C.] W Virginia Univ, Morgantown, WV 26506 USA. [Cheng, Shi] Appl Micro Circuits Corp, Sunnyvale, CA USA. [Torrieri, Don] USA, Res Lab, Adelphi, MD USA. RP Valenti, MC (reprint author), W Virginia Univ, Morgantown, WV 26506 USA. EM valenti@ieee.org; shi.cheng@gmail.com; dtorr@arl.army.mil OI Valenti, Matthew/0000-0001-6089-0509 FU National Science Foundation [CNS-0750821] FX M. C. Valenti's contribution was sponsored by the National Science Foundation under Award No. CNS-0750821. NR 17 TC 4 Z9 5 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD JUL PY 2010 VL 58 IS 7 BP 2046 EP 2054 DI 10.1109/TCOMM.2010.07.090453 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 652GE UT WOS:000281990400019 ER PT J AU Gribok, AV Buller, MJ Hoyt, RW Reifman, J AF Gribok, Andrei V. Buller, Mark J. Hoyt, Reed W. Reifman, Jaques TI A Real-Time Algorithm for Predicting Core Temperature in Humans SO IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE LA English DT Article DE Autoregressive (AR) models; core-temperature predictions; real-time prediction AB In this paper, we present a real-time implementation of a previously developed offline algorithm for predicting core temperature in humans. The real-time algorithm uses a zero-phase Butterworth digital filter to smooth the data and an autoregressive (AR) model to predict core temperature. The performance of the algorithm is assessed in terms of its prediction accuracy, quantified by the root mean squared error (RMSE), and in terms of prediction uncertainty, quantified by statistically based prediction intervals (PIs). To evaluate the performance of the algorithm, we simulated real-time implementation using core-temperature data collected during two different field studies, involving ten different individuals. One of the studies includes a case of heat illness suffered by one of the participants. The results indicate that although the real-time predictions yielded RMSEs that are larger than those of the offline algorithm, the real-time algorithm does produce sufficiently accurate predictions for practically meaningful prediction horizons (similar to 20 min). The algorithm reached alert (39 degrees C) and alarm (39.5 degrees C) thresholds for the heat-ill individual but did not even attain the alert threshold for the other individuals, demonstrating the algorithm's good sensitivity and specificity. The PIs reflected, in an intuitively expected manner, the uncertainty associated with real-time forecast as a function of prediction horizon and core-temperature variability. The results also corroborate the feasibility of "universal" AR models, where an offline-developed model based on one individual's data could be used to predict any other individual in real time. We conclude that the real-time implementation of the algorithm confirms the attributes observed in the offline version and, hence, could be considered as a warning tool for impending heat illnesses. C1 [Gribok, Andrei V.; Reifman, Jaques] USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA. [Buller, Mark J.; Hoyt, Reed W.] USA, Inst Environm Med, Natick, MA 01760 USA. [Buller, Mark J.] Brown Univ, Providence, RI 02912 USA. [Reifman, Jaques] USA, Dept Army, Dept Def Biotechnol High Performance Comp Softwar, Inst Force Hlth Protect, Frederick, MD 21702 USA. RP Gribok, AV (reprint author), Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. EM jaques.reifman@us.army.mil FU Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command FX Manuscript received March 2, 2009; revised December 23, 2009; accepted February 11, 2010. Date of publication April 5, 2010; date of current version July 9, 2010. This work was supported in part by the Military Operational Medicine Research Area Directorate of the U.S. Army Medical Research and Materiel Command. NR 11 TC 7 Z9 7 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1089-7771 J9 IEEE T INF TECHNOL B JI IEEE T. Inf. Technol. Biomed. PD JUL PY 2010 VL 14 IS 4 BP 1039 EP 1045 DI 10.1109/TITB.2010.2043956 PG 7 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Medical Informatics SC Computer Science; Mathematical & Computational Biology; Medical Informatics GA 633DW UT WOS:000280480700017 PM 20371418 ER PT J AU Subramanyam, G Patterson, M Leedy, K Neidhard, R Varanasi, C Zhang, CH Steinhauer, G AF Subramanyam, Guru Patterson, Mark Leedy, Kevin Neidhard, Robert Varanasi, Chakrapani Zhang, Chenhao Steinhauer, Gregg TI Linearity and Temperature Dependence of Large-Area Processed High-Q Barium Strontium Titanate Thin-film Varactors SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID MICROWAVE APPLICATIONS AB Ba(0.6)Sr(0.4)TiO(3) (BST) thin-films with large dielectric tunability as high as 4: 1 were obtained using a large-area pulsed laser deposition process, with low loss-tangents below 0.01 at zero-bias and 10 GHz. This paper summarizes experimental results obtained on large-area processed BST thin films on 100-mm-diameter sapphire substrates characterized using a varactor shunt switch test structure. Varactors with 0.25-mu m-thick BST films exhibited large dielectric tunability, the relative dielectric permittivity at zero bias of 990 tuned to 250 at an electric field of 320 kV/cm. The leakage current through the BST film was below 2 nA up to 6 V dc bias. The quality factor (Q) exceeded 300 at relatively low 6 V dc bias for the BST varactors at 1 GHz. These results confirm that large-area processed BST thin films are ready to compete with semiconductor varactors for commercial applications at RF, microwave, and millimeterwave frequencies. C1 [Subramanyam, Guru; Patterson, Mark; Zhang, Chenhao] Univ Dayton, Dept Elect & Comp Engn, Dayton, OH 45469 USA. [Leedy, Kevin; Neidhard, Robert] USA, Res Lab, Sensors Directorate, Wright Patterson Air Force Base, Dayton, OH USA. [Varanasi, Chakrapani] Univ Dayton, Res Inst, Dayton, OH 45469 USA. [Steinhauer, Gregg] Analog Bridge Inc, Beavercreek, OH USA. RP Subramanyam, G (reprint author), Univ Dayton, Dept Elect & Comp Engn, Dayton, OH 45469 USA. EM guru.subramanyam@notes.dayton.edu RI Leedy, Kevin/E-9968-2010 NR 9 TC 3 Z9 3 U1 1 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 2010 VL 57 IS 7 BP 1692 EP 1695 DI 10.1109/TUFFC.2010.1599 PG 4 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 656DU UT WOS:000282307200021 PM 20639162 ER PT J AU Keen, EF Murray, CK Robinson, BJ Hospenthal, DR Co, EMA Aldous, WK AF Keen, Edward F., III Murray, Clinton K. Robinson, Brian J. Hospenthal, Duane R. Co, Edgie-Mark A. Aldous, Wade K. TI Changes in the Incidences of Multidrug-Resistant and Extensively Drug-Resistant Organisms Isolated in a Military Medical Center SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID CARE-ASSOCIATED INFECTIONS; COMBAT-RELATED INJURIES; ACINETOBACTER-BAUMANNII; IRAQ; AFGHANISTAN; PERSONNEL; IMPACT; SUSCEPTIBILITY; MORTALITY; BACTERIA AB BACKGROUND. Multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa have emerged as the causes of nosocomial infections in critically ill patients. OBJECTIVE. To characterize the incidence of these MDR bacteria over time in the military healthcare system, comparing isolates recovered from overseas combat casualties with isolates recovered from local military and civilian patients. METHODS. Retrospective electronic records review of culture and/or susceptibility testing results of patients admitted to a military level I trauma center in San Antonio, Texas, during the period from January 2001 through December 2008. Multidrug resistance was defined as the first isolated organism resistant to 3 or more classes of antimicrobial agents. RESULTS. Over time, the percentage of MDR A. baumannii isolates increased from 4% to 55%, whereas the percentage of MDR P. aeruginosa isolates increased from 2% to 8%. Respiratory tract specimens had a higher percentage of MDR A. baumannii isolates (49%), compared with specimens obtained from blood (30%), wound sites (24%), or urine (19%). No difference in the percentages of MDR P. aeruginosa isolates was observed with regard to source of specimen. The percentage of MDR A. baumannii isolates recovered was higher among patients who had been deployed overseas (52%) than among local patients (20%). When isolates recovered from patients in the burn intensive care unit (53% of MDR A. baumannii isolates) were removed from analysis, the percentage of MDR A. baumannii isolates decreased from 38% to 30% while the percentage of MDR P. aeruginosa isolates remained unaffected. CONCLUSION. The percentage of MDR A. baumannii isolates increased in this facility among combat casualties and among local patients, which indicates nosocomial transmission; however, there was no significant increase in the percentage of MDR P. aeruginosa isolates. Isolated changes in the MDR pathogens within a facility can occur. Possible interventions to limit the spread of these organisms could include implementing aggressive infection control practices, controlling antibiotic use, and using active culture surveillance. Infect Control Hosp Epidemiol 2010; 31(7):728-732 C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Co, Edgie-Mark A.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Co, Edgie-Mark/A-9142-2011 NR 19 TC 22 Z9 24 U1 4 U2 8 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUL PY 2010 VL 31 IS 7 BP 728 EP 732 DI 10.1086/653617 PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 605VB UT WOS:000278374000010 PM 20500036 ER PT J AU Aungst, MJ Fischer, JR Bonhage, MR Albright, TS Noel, KA Wright, J AF Aungst, Matthew J. Fischer, John R. Bonhage, Michael R. Albright, Todd S. Noel, Kathleen A. Wright, Johnnie TI Rectovaginal fistula model in the New Zealand white rabbit SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article DE Fistula; Animal models; New Zealand white rabbit; Rectovaginal fistula ID FRESH OBSTETRIC FISTULAS; VAGINA MODEL; DERMAL GRAFT; FASCIA LATA; REPAIR; MANAGEMENT; CLOSURE AB The purpose of this study was to create an animal model to study rectovaginal fistula repair. Fourteen New Zealand white rabbits underwent surgical creation of a rectovaginal fistula. The technique was developed with a pilot study conducted on the first two animals, then standardized and performed on the remaining 12 rabbits. The standardized technique included making a defect in the rectovaginal septum using a 3-mm skin punch then splinting the defect with 6-mm tubing for 2 weeks. Using the standardized technique, a fistula was successfully created in all 12 rabbits ranging from 1 to 5 mm (mean = 2.8 mm, SD = 1.1). A 95% tolerance interval was calculated for the model and predicted that a successful fistula can be created ranging from 0.3 to 5.2 mm in 85% of attempts with the model. The New Zealand white rabbit is a promising animal model to study rectovaginal fistula repair. C1 [Aungst, Matthew J.; Fischer, John R.; Noel, Kathleen A.; Wright, Johnnie] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Washington, DC 20307 USA. [Bonhage, Michael R.] Armed Forces Inst Pathol, Dept Vet Pathol, Div Lab & Anim Med, Washington, DC 20306 USA. [Albright, Todd S.] USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Aungst, MJ (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Bldg 2,Rm 2J06,6900 Georgia Ave, Washington, DC 20307 USA. EM Matt.Aungst@yahoo.com NR 15 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0937-3462 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD JUL PY 2010 VL 21 IS 7 BP 885 EP 888 DI 10.1007/s00192-010-1118-0 PG 4 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA 601VT UT WOS:000278094200021 PM 20186389 ER PT J AU Crum-Cianflone, NF Grandits, G Echols, S Ganesan, A Landrum, M Weintrob, A Barthel, R Agan, B AF Crum-Cianflone, Nancy F. Grandits, Greg Echols, Sara Ganesan, Anuradha Landrum, Michael Weintrob, Amy Barthel, Robert Agan, Brian CA Infect Dis Clinical Res Program TI Trends and Causes of Hospitalizations Among HIV-Infected Persons During the Late HAART Era: What Is the Impact of CD4 Counts and HAART Use? SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE complications; epidemiology; HIV; hospitalization; morbidity; MRSA infections; surgery ID ACTIVE ANTIRETROVIRAL THERAPY; INPATIENT ADMISSIONS; RATES; COHORT; MORTALITY; DEATH; AIDS; MORBIDITY; HEPATITIS; DIAGNOSES AB Background: Declining rates of hospitalizations occurred shortly after the availability of highly active antiretroviral therapy (HAART). However, trends in the late HAART era are less defined, and data on the impact of CD4 counts and HAART use on hospitalizations are needed. Methods: We evaluated hospitalization rates from 1999 to 2007 among HIV-infected persons enrolled in a large US military cohort. Poisson regression was used to compare hospitalization rates per year and to examine factors associated with hospitalization. Results: Of the 2429 participants, 822 (34%) were hospitalized at least once with 1770 separate hospital admissions. The rate of hospitalizations (137 per 1000 person-years) was constant over the study period [relative rate (RR) 1.00 per year change, 95% confidence interval: 0.98 to 1.02]. The hospitalization rates due to skin infections (RR: 1.50, P = 0.02), methicillin-resistant staphylococcus aureus (RR: 3.19, P = 0.03), liver disease (RR: 1.71, P = 0.04), and surgery (RR: 1.17, P = 0.04) significantly increased over time, whereas psychological causes (RR: 0.60, P < 0.01) and trauma (RR: 0.54, P < 0.01) decreased. In the multivariate model, higher nadir CD4 (RR: 0.92 per 50 cells, P < 0.01) and higher proximal CD4 counts (RR of 0.71 for 350-499 vs. <350 cells/mm(3) and RR 0.67 for >= 500 vs. <350 cells/mm3, both P < 0.01) were associated with lower risk of hospitalization. Risk of hospitalization was constant for proximal CD4 levels above 350 (RR: 0.94 P = 0.51, CD4 >= 500 vs. 350-499). HAART was associated with a reduced risk of hospitalization among those with a CD4,350 (RR: 0.72, P = 0.02) but had smaller estimated and nonsignificant effects at higher CD4 levels (RR: 0.81, P = 0.33 and 1.06, P = 0.71 for CD4 <350-499 and >= 500, respectively). Conclusions: Hospitalizations continue to occur at high rates among HIV-infected persons with increasing rates for skin infections, methicillin-resistant staphylococcus aureus, liver disease, and surgeries. Factors associated with a reduced risk of hospitalization include CD4 counts >350 cells per cubic millimeter and HAART use among patients with a CD4 count <350 cells per cubic millimeter. C1 [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, San Diego, CA 92134 USA. [Crum-Cianflone, Nancy F.; Grandits, Greg; Echols, Sara; Ganesan, Anuradha; Landrum, Michael; Weintrob, Amy; Barthel, Robert; Agan, Brian] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Grandits, Greg] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [Landrum, Michael] San Antonio Mil Med Ctr, Infect Dis Clin, San Antonio, TX USA. [Weintrob, Amy] Walter Reed Army Med Ctr, Infect Dis Clin, Washington, DC 20307 USA. [Barthel, Robert] USN, Med Ctr Portsmouth, Infect Dis Clin, Portsmouth, VA USA. RP Crum-Cianflone, NF (reprint author), USN, San Diego Med Ctr, Clin Invest Dept KCA, Infect Dis Clin, 34800 Bob Wilson Dr,Ste 5, San Diego, CA 92134 USA. EM nancy.crum@med.navy.mil OI Agan, Brian/0000-0002-5114-1669 FU Uniformed Services University of the Health Sciences [028]; National Institute of Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-5072] FX Support for this work (IDCRP #028) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Inter-Agency Agreement Y1-AI-5072. NR 37 TC 40 Z9 42 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JUL 1 PY 2010 VL 54 IS 3 BP 248 EP 257 DI 10.1097/QAI.0b013e3181c8ef22 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 613YV UT WOS:000279022300004 PM 20658748 ER PT J AU Saathoff, E Pritsch, M Geldmacher, C Hoffmann, O Koehler, RN Maboko, L Maganga, L Geis, S McCutchan, FE Kijak, GH Kim, JH Arroyo, MA Gerhardt, M Tovanabutra, S Robb, ML Williamson, C Michael, NL Hoelscher, M AF Saathoff, Elmar Pritsch, Michael Geldmacher, Christof Hoffmann, Oliver Koehler, Rebecca N. Maboko, Leonard Maganga, Lucas Geis, Steffen McCutchan, Francine E. Kijak, Gustavo H. Kim, Jerome H. Arroyo, Miguel A. Gerhardt, Martina Tovanabutra, Sodsai Robb, Merlin L. Williamson, Carolyn Michael, Nelson L. Hoelscher, Michael TI Viral and Host Factors Associated With the HIV-1 Viral Load Setpoint in Adults From Mbeya Region, Tanzania SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE acute infection; Africa; HIV-1 infection; HLA class I alleles; multiple infection; viral load setpoint ID IMMUNODEFICIENCY-VIRUS TYPE-1; SET-POINT; DISEASE PROGRESSION; GENDER-DIFFERENCE; DUAL INFECTIONS; WEST-AFRICA; RNA LEVELS; WOMEN; RISK; SUBTYPE AB Background: The viral load setpoint (VLS) is an important predictor of HIV disease progression, but there is a lack of information regarding the VLS and its possible determinants in African populations. Methods: Initially HIV-negative adults from 3 distinct groups (female bar workers, females, and males from the general population) were followed for up to 4 years. The VLS was calculated for 108 seroconverters and associations of the VLS with possible risk factors were analyzed using univariate and multivariate regression. Results: The median VLS for female bar workers, females, and males from the general population were 69,850, 28,600, and 158,000 RNA copies per milliliter, respectively. Significant associations with an elevated viral load were observed for male gender [risk ratio (RR) = 1.83, 95% confidence interval (95% CI) = 1.14 to 2.93], the expression of harmful HLA I alleles (RR = 1.73, 95% CI = 1.13 to 2.66) and multiple infection with different HIV-1 subtypes (RR = 1.65, 95% CI = 1.03 to 2.66). Bar workers were considerably more often infected with different HIV-1 subtypes than participants from the general population. Conclusions: Our study confirms that gender and the expression of different HLA class I alleles are important determinants of the viremia at VLS, and it also corroborates an earlier finding that multiple infection with different HIV-1 subtypes is associated with a higher VLS. C1 [Saathoff, Elmar; Pritsch, Michael; Geldmacher, Christof; Hoffmann, Oliver; Geis, Steffen; Gerhardt, Martina; Hoelscher, Michael] Univ Munich, Dept Trop Med & Infect Dis, D-80802 Munich, Germany. [Koehler, Rebecca N.; McCutchan, Francine E.; Kijak, Gustavo H.; Kim, Jerome H.; Tovanabutra, Sodsai; Robb, Merlin L.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Dept Mol Virol & Pathogenesis, Rockville, MD USA. [Maboko, Leonard; Maganga, Lucas; Geis, Steffen; Gerhardt, Martina] MMRP, Mbeya, Tanzania. [McCutchan, Francine E.] Bill & Melinda Gates Fdn, Seattle, WA USA. [Arroyo, Miguel A.] Walter Reed Army Med Ctr, Clin Microbiol Fellowship Program, Washington, DC 20307 USA. [Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Div Retrovirol, Directorate Clin Res, Rockville, MD USA. [Williamson, Carolyn] Univ Cape Town, Fac Hlth Sci, Div Med Virol, Inst Infect Dis & Mol Med, ZA-7700 Rondebosch, South Africa. RP Saathoff, E (reprint author), Univ Munich, Dept Trop Med & Infect Dis, Leopoldstr 5, D-80802 Munich, Germany. EM elmarsaathoff@web.de RI Hoelscher, Michael/D-3436-2012; OI , Michael/0000-0001-7383-8750; , Carolyn/0000-0003-0125-1226; Arroyo, Miguel/0000-0001-7416-8867 FU Henry M. Jackson Foundation for the Advancement of Military Medicine [DAMD17-98-2-7007]; United States Department of Defense [DAMD17-98-2-7007]; National Institute for Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-2642-11]; European Commission [INCO-DC, ICA-CT-1999-10007]; MMRP FX The longitudinal HIV Superinfection Study laboratory analysis and the CODE study were supported by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the United States Department of Defense under DAMD17-98-2-7007, and by the National Institute for Allergy and Infectious Diseases, National Institutes of Health ("HIV Vaccine Research and Development - Project 2" Y1-AI-2642-11). The longitudinal HIV Superinfection study was also supported by a grant from the European Commission (DG XII, INCO-DC, ICA-CT-1999-10007).; We would like to thank the participants of this study for their patience and the MMRP staff involved in this study for their dedicated support. NR 38 TC 12 Z9 12 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JUL 1 PY 2010 VL 54 IS 3 BP 324 EP 331 DI 10.1097/QAI.0b013e3181cf30ba PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 613YV UT WOS:000279022300014 PM 20632457 ER PT J AU Kenefick, RW Cheuvront, SN Palombo, LJ Ely, BR Sawka, MN AF Kenefick, R. W. Cheuvront, S. N. Palombo, L. J. Ely, B. R. Sawka, M. N. TI Skin temperature modifies the impact of hypohydration on aerobic performance SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE dehydration; total work; graded ambient temperature; cutaneous blood flow; mean arterial pressure ID EXERCISE PERFORMANCE; PROLONGED EXERCISE; CARDIAC-OUTPUT; ENDURANCE PERFORMANCE; DEHYDRATION; HEAT; HYPERTHERMIA; FATIGUE; BLOOD; BODY AB Kenefick RW, Cheuvront SN, Palombo LJ, Ely BR, Sawka MN. Skin temperature modifies the impact of hypohydration on aerobic performance. J Appl Physiol 109: 79-86, 2010. First published April 8, 2010; doi:10.1152/japplphysiol.00135.2010.-This study determined the effects of hypohydration on aerobic performance in compensable [evaporative cooling requirement (E(req)) < maximal evaporative cooling (E(max))] conditions of 10 degrees C [7 degrees C wet bulb globe temperature (WBGT)], 20 degrees C (16 degrees C WBGT), 30 degrees C (22 degrees C WBGT), and 40 degrees C (27 degrees C WBGT) ambient temperature (T(a)). Our hypothesis was that 4% hypohydration would impair aerobic performance to a greater extent with increasing heat stress. Thirty-two men [22 +/- 4 yr old, 45 +/- 8 ml.kg(-1).min(-1) peak O(2) uptake ((V) over dotO(2peak))] were divided into four matched cohorts (n = 8) and tested at one of four T(a) in euhydrated (EU) and hypohydrated (HYPO, -4% body mass) conditions. Subjects completed 30 min of preload exercise (cycle ergometer, 50% (V) over dotO(2peak)) followed by a 15 min self-paced time trial. Timetrial performance (total work, change from EU) was -3% (P = 0.1), -5% (P = 0.06), -12% (P < 0.05), and -23% (P < 0.05) in 10 degrees C, 20 degrees C, 30 degrees C, and 40 degrees C T(a), respectively. During preload exercise, skin temperature (T(sk)) increased by similar to 4 degrees C per 10 degrees C T(a), while core (rectal) temperature (T(re)) values were similar within EU and HYPO conditions across all T(a). A significant relationship (P < 0.05, r = 0.61) was found between T(sk) and the percent decrement in time-trial performance. During preload exercise, hypohydration generally blunted the increases in cardiac output and blood pressure while reducing blood volume over time in 30 degrees C and 40 degrees C T(a). Our conclusions are as follows: 1) hypohydration degrades aerobic performance to a greater extent with increasing heat stress; 2) when T(sk) is >29 degrees C, 4% hypohydration degrades aerobic performance by similar to 1.6% for each additional 1 degrees C T(sk); and 3) cardiovascular strain from high skin blood flow requirements combined with blood volume reductions induced by hypohydration is an important contributor to impaired performance. C1 [Kenefick, R. W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Kenefick, RW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil NR 41 TC 47 Z9 47 U1 4 U2 19 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 2010 VL 109 IS 1 BP 79 EP 86 DI 10.1152/japplphysiol.00135.2010 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 617OY UT WOS:000279291500011 PM 20378704 ER PT J AU Nindl, BC Alemany, JA Tuckow, AP Rarick, KR Staab, JS Kraemer, WJ Maresh, CM Spiering, BA Hatfield, DL Flyvbjerg, A Frystyk, J AF Nindl, Bradley C. Alemany, Joseph A. Tuckow, Alexander P. Rarick, Kevin R. Staab, Jeffery S. Kraemer, William J. Maresh, Carl M. Spiering, Barry A. Hatfield, Disa L. Flyvbjerg, Allan Frystyk, Jan TI Circulating bioactive and immunoreactive IGF-I remain stable in women, despite physical fitness improvements after 8 weeks of resistance, aerobic, and combined exercise training SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE kinase receptor activation assay; insulin-like growth factor binding proteins; physical training; hormones ID GROWTH-FACTOR-I; SKELETAL-MUSCLE HYPERTROPHY; HUMAN SERUM; BODY-COMPOSITION; ENERGY-BALANCE; FACTOR (IGF)-I; BINDING PROTEIN-1; SLEEP RESTRICTION; SYSTEM RESPONSES; INSULIN AB Nindl BC, Alemany JA, Tuckow AP, Rarick KR, Staab JS, Kraemer WJ, Maresh CM, Spiering BA, Hatfield DL, Flyvbjerg A, Frystyk J. Circulating bioactive and immunoreactive IGF-I remain stable in women, despite physical fitness improvements after 8 weeks of resistance, aerobic, and combined exercise training. J Appl Physiol 109: 112-120, 2010. First published April 15, 2010; doi:10.1152/japplphysiol.00025.2010.-Insulin-like growth factor-I (IGF-I) is regulated by a number of IGF-binding proteins (IGFBPs) and proteases that influence IGF-I bioactivity. A specific IGF-I kinase receptor activation assay (KIRA) has been developed that determines the ability of IGF-I to activate the IGF-I receptor by quantification of intracellular receptor autophosphorylation on IGF-I binding. KIRA-assessed IGF-I bioactivity has not been utilized within the context of chronic exercise training paradigms. This study measured total and free immunoreactive IGF-I, bioactive IGF-I, and IGFBP-1, -2, and -3 before (Pre), during (Mid), and after (Post) 8 wk of exercise training in young, healthy women, who were randomized into one of four groups: control (n = 10), resistance (n = 18), aerobic (n = 13), and combined (n = 15) exercise training. The training programs were effective in improving physical fitness specific to the exercise mode engaged in: increases were observed for lean mass (similar to 2%), aerobic fitness (6-7%), and upper (20-24%) and lower (15-48%) body strength (all P values < 0.05). By contrast, no time, group, or interaction effects were observed for the circulating IGF-I system, as immunoreactive total (Pre = 264 +/- 16 mu g/l; Mid = 268 +/- 17 mu g/l; Post = 271 +/- 17 mu g/l), free (Pre = 0.70 +/- 0.1 mu g/l; Mid = 0.63 +/- 0.1 mu g/l; Post = 0.63 +/- 0.2 mu g/l) and bioactive (Pre = 2.35 +/- 0.3 mu g/l; Mid = 2.25 +/- 0.3 mu g/l; Post = 2.33 +/- 0.3 mu g/l) IGF-I were unchanged throughout the study. All IGFBP measures were also unchanged. We conclude that increased lean mass, aerobic fitness, and upper and lower body strength resulting from an 8-wk exercise training programs can occur without concomitant increases in either circulating bioactive or immunoreactive IGF-I, as well as associated IGFBPs. In terms of reflecting positive anabolic neuromuscular outcomes, these data do not support a role for endocrine-derived IGF-I. C1 [Nindl, Bradley C.; Alemany, Joseph A.; Tuckow, Alexander P.; Rarick, Kevin R.; Staab, Jeffery S.] USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. [Kraemer, William J.; Maresh, Carl M.; Spiering, Barry A.; Hatfield, Disa L.] Univ Connecticut, Human Performance Lab, Storrs, CT USA. [Flyvbjerg, Allan; Frystyk, Jan] Aarhus Univ Hosp, Med Res Labs, Inst Clin Med, DK-8000 Aarhus, Denmark. RP Nindl, BC (reprint author), USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. EM Bradley.nindl@us.army.mil FU US Army Medical Research FX This research was supported by a grant from the US Army Medical Research and Material Command Bone Health and Military Medical Readiness Research Program to BCN. NR 43 TC 16 Z9 16 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 2010 VL 109 IS 1 BP 112 EP 120 DI 10.1152/japplphysiol.00025.2010 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 617OY UT WOS:000279291500015 PM 20395543 ER PT J AU Reynolds, SJ Leavitt, K DeCelles, KA AF Reynolds, Scott J. Leavitt, Keith DeCelles, Katherine A. TI Automatic Ethics: The Effects of Implicit Assumptions and Contextual Cues on Moral Behavior SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article DE automatic social cognition; moral decision making; moral behavior ID ASSOCIATION TEST; DECISION-MAKING; SOCIAL-BEHAVIOR; SELF-ESTEEM; MODEL; ATTITUDES; WORK; ORGANIZATIONS; STEREOTYPES; PERSPECTIVE AB We empirically examine the reflexive or automatic aspects of moral decision making. To begin, we develop and validate a measure of an individual's implicit assumption regarding the inherent morality of business. Then, using an in-basket exercise, we demonstrate that an implicit assumption that business is inherently moral impacts day-to-day business decisions and interacts with contextual cues to shape moral behavior. Ultimately, we offer evidence supporting a characterization of employees as reflexive inter-actionists: moral agents whose automatic decision-making processes interact with the environment to shape their moral behavior. C1 [Reynolds, Scott J.] Univ Washington, Michael G Foster Sch Business, Seattle, WA 98028 USA. [Leavitt, Keith] US Mil Acad, Army Ctr Profess Mil Eth, West Point, NY USA. [DeCelles, Katherine A.] Univ Toronto, Rotman Sch Management, Toronto, ON, Canada. RP Reynolds, SJ (reprint author), Univ Washington, Michael G Foster Sch Business, Box 353200, Seattle, WA 98028 USA. EM heyscott@u.washington.edu RI Leavitt, Keith/D-6686-2012 OI Leavitt, Keith/0000-0003-3729-3997 NR 68 TC 39 Z9 40 U1 3 U2 50 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 EI 1939-1854 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD JUL PY 2010 VL 95 IS 4 BP 752 EP 760 DI 10.1037/a0019411 PG 9 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 622ZJ UT WOS:000279705900011 PM 20604594 ER PT J AU Allan, PF Osborn, EC Chung, KK Wanek, SM AF Allan, Patrick F. Osborn, Erik C. Chung, Kevin K. Wanek, Sandra M. TI High-Frequency Percussive Ventilation Revisited SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID RESPIRATORY-DISTRESS-SYNDROME; MEAN AIRWAY PRESSURE; ACUTE LUNG INJURY; OSCILLATORY VENTILATION; ALVEOLAR PRESSURE; TIDAL VOLUME; INHALATION INJURY; GAS-EXCHANGE; CARDIOGENIC OSCILLATIONS; CONVENTIONAL VENTILATION AB High-frequency percussive ventilation (HFPV) has demonstrated a potential role as a rescue option for refractory acute respiratory distress syndrome and as a method for improving inhalation injury outcomes. Nevertheless, there is a lack of literature examining the practical application of HFPV theory toward either improving gas exchange or preventing possible ventilator-induced lung injury. This article will discuss the clinically pertinent aspects of HFPV, inclusive of high- and low-frequency ventilation. (J Burn Care Res 2010; 31: 510-520) C1 [Allan, Patrick F.; Osborn, Erik C.; Wanek, Sandra M.] Landstuhl Reg Med Ctr, Dept Pulm Crit Care & Sleep Med, D-09180 Landstuhl, Germany. [Chung, Kevin K.] USA, Inst Surg Res, Houston, TX USA. RP Allan, PF (reprint author), Landstuhl Reg Med Ctr, Dept Pulm Crit Care & Sleep Med, CMR 402,Box 307,APO AE, D-09180 Landstuhl, Germany. NR 52 TC 16 Z9 16 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2010 VL 31 IS 4 BP 510 EP 520 DI 10.1097/BCR.0b013e3181e4d605 PG 11 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 622DC UT WOS:000279638400001 PM 20616646 ER PT J AU Danks, RR Lairet, K AF Danks, Roy R. Lairet, Kimberly TI Innovations in Caring for a Large Burn in the Iraq War Zone SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID VIENNESE CONCEPT; MEEK AB The authors report on a single case of a large, civilian burn cared for at a U.S. military hospital during Operation Iraqi Freedom. The management of the patient, using a large negative pressure wound therapy device and the Meek grafting technique, is reviewed. This is a case report. The patient survived his injury. In Iraq, most patients with this severity of injury succumb to the injury. By using two innovative techniques, the authors found that the patient was able to survive his injury and return to his home. (J Burn Care Res 2010; 31: 665-669) C1 [Danks, Roy R.; Lairet, Kimberly] USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. RP Danks, RR (reprint author), 1001 6th Ave,Ste 230, Leavenworth, KS 66048 USA. NR 5 TC 9 Z9 10 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2010 VL 31 IS 4 BP 665 EP 669 DI 10.1097/BCR.0b013e3181e4c8aa PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 622DC UT WOS:000279638400020 PM 20523231 ER PT J AU Frech, C Harris, H Woodbridge, CM Coppola, B AF Frech, Cheryl Harris, Hal Woodbridge, C. M. Coppola, Brian TI Summer 2010 Books and Media Recommendations SO JOURNAL OF CHEMICAL EDUCATION LA English DT Editorial Material C1 [Frech, Cheryl] Univ Cent Oklahoma, Dept Chem, Edmond, OK 73034 USA. [Harris, Hal] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA. [Woodbridge, C. M.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Coppola, Brian] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA. RP Frech, C (reprint author), Univ Cent Oklahoma, Dept Chem, Edmond, OK 73034 USA. EM cfrech@uco.edu RI Coppola, Brian P/G-3709-2016 OI Coppola, Brian P/0000-0001-7226-0942 NR 32 TC 1 Z9 1 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD JUL PY 2010 VL 87 IS 7 BP 665 EP 671 DI 10.1021/ed100426a PG 7 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA 611PO UT WOS:000278832200005 ER PT J AU Kwon, DH Bisch, FC Herold, RW Pompe, C Bastone, P Rodriguez, NA Susin, C Wikesjo, UME AF Kwon, David H. Bisch, Frederick C. Herold, Robert W. Pompe, Cornelius Bastone, Patrizia Rodriguez, Nancy A. Susin, Cristiano Wikesjoe, Ulf M. E. TI Periodontal wound healing/regeneration following the application of rhGDF-5 in a beta-TCP/PLGA carrier in critical-size supra-alveolar periodontal defects in dogs SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE beta-tricalcium phosphate; bone; cementum; growth; differentiation factor-5; periodontal ligament; poly(lactic-co-glycolic acid); tissue engineering; periodontal regeneration ID BONE MORPHOGENETIC PROTEIN-2; HUMAN OSTEOGENIC PROTEIN-1; HUMAN GROWTH/DIFFERENTIATION FACTOR-5; HORIZONTAL CIRCUMFERENTIAL DEFECTS; WALL INTRABONY DEFECTS; III FURCATION DEFECTS; BABOON PAPIO-URSINUS; TISSUE REGENERATION; COLLAGEN SPONGE; DOUBLE MUTATIONS AB P>Aim The objective of this study was to evaluate the effect of a novel recombinant human GDF-5 (rhGDF-5) construct intended for onlay and inlay indications on periodontal wound healing/regeneration. Methods Contralateral, surgically created, critical-size, 6-mm, supra-alveolar periodontal defects in five adult Hound Labrador mongrel dogs received rhGDF-5 coated onto beta-tricalcium phosphate (beta-TCP) particles and immersed in a bioresorbable poly(lactic-co-glycolic acid) (PLGA) composite or the beta-TCP/PLGA carrier alone (control). The rhGDF-5 and control constructs were moulded around the teeth and allowed to set. The gingival flaps were then advanced; flap margins were adapted 3-4 mm coronal to the teeth and sutured. The animals were euthanized at 8 weeks post-surgery when block biopsies were collected for histometric analysis. Results Healing was generally uneventful. A few sites exhibited minor exposures. Three control sites and one rhGDF-5 site (in separate animals) experienced more extensive wound dehiscencies. The rhGDF-5 and control constructs were easy to apply and exhibited adequate structural integrity to support the mucoperiosteal flaps in this challenging onlay model. Limited residual beta-TCP particles were observed at 8 weeks for both rhGDF-5/beta-TCP/PLGA and beta-TCP/PLGA control sites. The rhGDF-5/beta-TCP/PLGA sites showed significantly greater cementum (2.34 +/- 0.44 versus 1.13 +/- 0.25 mm, p=0.02) and bone (2.92 +/- 0.66 versus 1.21 +/- 0.30 mm, p=0.02) formation compared with the carrier control. Limited ankylosis was observed in four of five rhGDF-5/beta-TCP/PLGA sites but not in control sites. Conclusions Within the limitations of this study, the results suggest that rhGDF-5 is a promising candidate technology in support of periodontal wound healing/regeneration. Carrier and rhGDF-5 dose optimization are necessary before further advancement of the technology towards clinical evaluation. C1 [Kwon, David H.; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, LAPCR, Dept Periodont, Augusta, GA 30912 USA. [Kwon, David H.; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, LAPCR, Dept Oral Biol, Augusta, GA 30912 USA. [Kwon, David H.; Bisch, Frederick C.; Herold, Robert W.] USA, Adv Educ Program Periodont, Ft Gordon, GA USA. [Bastone, Patrizia] Scil Technol GmbH, Martinsried, Germany. [Rodriguez, Nancy A.] Med Coll Georgia, Lab Anim Serv, Augusta, GA 30912 USA. RP Kwon, DH (reprint author), Med Coll Georgia, Sch Dent, LAPCR, Dept Periodont, AD 1430,1120 15th St, Augusta, GA 30912 USA. EM david.kwon@us.army.mil RI Wikesjo, Ulf/A-4159-2009; Susin, Cristiano/B-9822-2008 OI Wikesjo, Ulf/0000-0003-1607-0583; FU Scil Technology GmbH, Martinsried, Germany FX This study was supported by a grant from Scil Technology GmbH, Martinsried, Germany. Dr. Patrizia Bastone is an employee of Scil Technology GmbH. Dr. Cornelius Pompe is a previous employee of Scil Technology GmbH. Dr. Ulf ME Wikesjo serves as consultant to Scil Technology GmbH. This study was supported by a grant from Scil Technology GmbH, Martinsried, Germany. NR 57 TC 21 Z9 22 U1 0 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD JUL PY 2010 VL 37 IS 7 BP 667 EP 674 DI 10.1111/j.1600-051X.2010.01569.x PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 609HE UT WOS:000278645900011 PM 20492073 ER PT J AU Salinas, NL Faulkner, JA AF Salinas, Nathan L. Faulkner, Jeffrey A. TI Facial Trauma in Operation Iraqi Freedom Casualties: An Outcomes Study of Patients Treated From April 2006 Through October 2006 SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Facial fracture; intermaxillary fixation; open reduction and internal fixation; war trauma ID NECK INJURIES; HEAD; WAR; AFGHANISTAN AB This study investigates the postoperative complication rate in American military members treated for fractures of the facial skeleton with either immediate fixation in the Operation Iraqi Freedom combat theater or delayed fixation after transport out of the combat theater. Based on an army head and neck surgeon's case log, retrospective chart review was performed on 21 American active-duty patients evaluated for facial fractures in Balad, Iraq, between April 16, 2006, and October 30, 2006. Follow-up standardized patient interviews and review of electronic medical records were conducted to assess the postoperative clinical course and identify postoperative complications. Facial fractures involved the mandible (62%), the orbit (62%), nasal bones (48%), the midface (38%), the frontal bone (29%), the zygoma (24%), and the temporal bone (5%). Fourteen patients (67%) with facial fractures were treated definitively with open reduction and internal fixation surgery in Balad. Seven patients (33%) had delayed treatment. Overall, the major complication rate was 7% in the immediate fixation group, compared with 57% in the delayed treatment group (P < 0.04). Infectious complications occurred in 1 patient (7%) from the immediate fixation group requiring removal of exposed hardware, whereas 3 patients (43%) from the delayed treatment group experienced infectious complications requiring re-operation (P < 0.09). Although major complications were associated with both immediate and delayed definitive treatment, major complications were more likely to be associated with delayed treatment. The deployed surgeon should use clinical judgment in repairing facial fractures in theater. If treatment is delayed, every effort should be made to affect a timely repair of the fractures. C1 [Salinas, Nathan L.] Brooke Army Med Ctr, Attent MCHE SDT OTO HNS, Dept Otolaryngol Head & Neck Surg, Ft Sam Houston, TX 78234 USA. RP Salinas, NL (reprint author), Brooke Army Med Ctr, Attent MCHE SDT OTO HNS, Dept Otolaryngol Head & Neck Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Nathan.salinas@us.army.mil NR 7 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD JUL PY 2010 VL 21 IS 4 BP 967 EP 970 DI 10.1097/SCS.0b013e3181e17ab5 PG 4 WC Surgery SC Surgery GA 628UV UT WOS:000280149100008 PM 20613582 ER PT J AU Pereira, BMT Ryan, ML Ogilvie, MP Gomez-Rodriguez, JC McAndrew, P Garcia, GD Proctor, KG AF Pereira, Bruno M. T. Ryan, Mark L. Ogilvie, Michael P. Carlos Gomez-Rodriguez, Juan McAndrew, Patrick Garcia, George D. Proctor, Kenneth G. TI Predeployment Mass Casualty and Clinical Trauma Training for US Army Forward Surgical Teams SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Combat casualty care; mass casualty; forward surgical team; trauma; military training ID EXPERIENCE; FREEDOM AB Since the beginning of the program in 2002, 84 Forward Surgical Teams (FSTs) have rotated through the Army Trauma Training Center (ATTC) at the University of Miami/Ryder Trauma Center including all those deployed to Iraq and Afghanistan. The purpose of this study was to provide the latest updates of our experience with FSTs at the ATTC. Before deployment, each FST participates in a 2-week training rotation at the ATTC. The rotation is divided into 3 phases. Phase 1 is to refresh FST knowledge regarding the initial evaluation and management of the trauma patient. Phase 2 is the clinical phase and is conducted entirely at the Ryder Trauma Center. The training rotation culminates in phase 3, the Capstone exercise. During the Capstone portion of their training, the entire 20-person FST remains at the Ryder Trauma Center and is primarily responsible for the evaluation and resuscitation of all patients arriving over a 24-hour period. Subject awareness concerning their role within the team improved from 71% to 95%, indicating that functioning as a team in the context of the mass casualty training exercise along with clinical codes was beneficial. The clinical component of the rotation was considered by 47% to be the most valuable aspect of the training. Our experience strongly suggests that a multimodality approach is beneficial for preparing a team of individuals with minimal combat (or trauma) experience for the rigors of medical care and triage on the battlefield. The data provided by participants rotating through the ATTC show that through clinical exposure and simulation over a 2-week period, FST performance is optimized by defining provider roles and improving communication. The mass casualty training exercise is a vital component of predeployment training that participants feel is valuable in preparing them for the challenges that lay ahead. C1 [Proctor, Kenneth G.] Univ Miami, Miller Sch Med, Dewitt Daughtry Family Dept Surg, Div Trauma & Surg Crit Care, Miami, FL 33136 USA. [McAndrew, Patrick] USA, Washington, DC USA. [Garcia, George D.] Jackson Mem Hosp, Miami, FL USA. RP Proctor, KG (reprint author), Univ Miami, Miller Sch Med, Dewitt Daughtry Family Dept Surg, Div Trauma & Surg Crit Care, 1800 NW 10th Ave,T245, Miami, FL 33136 USA. EM Kproctor@med.miami.edu FU Department of Defense [W81K04-06-C-0021]; Office of Naval Research [N140610670] FX Financial support for this research was provided in part by contract #W81K04-06-C-0021 from the Department of Defense and grant N140610670 from the Office of Naval Research. NR 11 TC 11 Z9 11 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD JUL PY 2010 VL 21 IS 4 BP 982 EP 986 DI 10.1097/SCS.0b013e3181e1e791 PG 5 WC Surgery SC Surgery GA 628UV UT WOS:000280149100011 PM 20613574 ER PT J AU Salinas, NL Eller, RL Davis, MR Rasmussen, TE AF Salinas, Nathan L. Eller, Robert L. Davis, Michael R. Rasmussen, Todd E. TI Mass Casualty Response of a Modern Deployed Head and Neck Surgical Team SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE Multiple casualty; head and neck surgery; otolaryngology; military; explosive; maxillofacial; Global War on Terror ID RESOURCE UTILIZATION; INCIDENTS; INJURIES AB Background: The battlefields of the Global War on Terror have created unique demands on deployed surgical teams. Modern high-energy fragmentation devices often inflict complex head and neck injuries. This series analyzes the role of the head and neck surgical team during 3 separate single explosive events that led to civilian multiple casualty incidents (MCIs) treated at a military theater hospital in Iraq from February to April 2007. Methods: All MCIs occurring between February and April 2008 with triage and treatment at the 332nd Air Force Theater Hospital in Balad, Iraq, were identified and reviewed. Injury Severity Score, admission injury pattern, length of hospital stay, head and neck procedures, non-head and neck procedures, and clinical duties performed by the otolaryngology surgeon were recorded and analyzed. Results: Three MCIs occurring during the period of February to April 2008 were reviewed and described as incidents A, B, and C. A total of 50 patients were involved. Eighteen patients (36%) were treated for head and neck trauma. The average ISS for the non-head and neck trauma group was 15.8 (range, 1-43), whereas the head and neck trauma group average ISS was 23.6 (range, 2-75) (P < 0.06). The most commonly performed head and neck procedures included repair of facial lacerations, maxillomandibular fixation, and operative reduction internal fixation of facial fractures. The head and neck surgeon also performed airway triage and assisted with procedures performed by other specialties. Conclusions: By reviewing 3 MCIs and the operative log of the involved otolaryngologist, this review illustrates how the otolaryngologist's clinical knowledge base and surgical domain allow this specialist to uniquely contribute in response to a mass casualty incident. C1 [Eller, Robert L.; Rasmussen, Todd E.] Wilford Hall USAF Med Ctr, Div Surg, Lackland AFB, TX 78236 USA. [Salinas, Nathan L.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Davis, Michael R.] Wright Patterson USAF Med Ctr, Wright Patterson AFB, OH USA. [Davis, Michael R.; Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Rasmussen, TE (reprint author), Wilford Hall USAF Med Ctr, Div Surg, Lackland AFB, TX 78236 USA. EM drcutmd@aol.com NR 8 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD JUL PY 2010 VL 21 IS 4 BP 987 EP 990 DI 10.1097/SCS.0b013e3181e1e8de PG 4 WC Surgery SC Surgery GA 628UV UT WOS:000280149100012 PM 20613569 ER PT J AU Velicu, S Grein, CH Emelie, PY Itsuno, A Philips, JD Wijewarnasuriya, P AF Velicu, S. Grein, C. H. Emelie, P. Y. Itsuno, A. Philips, J. D. Wijewarnasuriya, P. TI MWIR and LWIR HgCdTe Infrared Detectors Operated with Reduced Cooling Requirements SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE HgCdTe; infrared detectors; high operating temperature; Auger suppression; lifetime; molecular-beam epitaxy; negative differential resistance; minority-carrier lifetime ID NONEQUILIBRIUM OPERATION; NUMERICAL-ANALYSIS; 1/F NOISE; PHOTODIODES; TEMPERATURE; SIMULATION; HG1-XCDXTE; DEVICES; DIODES; GAP AB In this work, we analyze Auger suppression in HgCdTe alloy-based device structures and determine the operation temperature improvements expected when Auger suppression occurs. We identified critical material (absorber dopant concentration and minority-carrier lifetime) requirements that must be satisfied for optimal performance characteristics. Calculated detectivity values of Auger-suppressed and standard double-layer planar heterostructure (DLPH) devices demonstrate consistently higher maximum background-limited temperatures over a range of cutoff wavelengths and generally higher detectivity values achieved by Auger-suppressed detectors. Furthermore, these devices can operate with comparable performance at up to 100 K higher than DLPH detectors operating at reference temperatures above 100 K. Results of these simulations demonstrate that Auger-suppressed detectors provide a significant advantage over DLPH devices for high-temperature operation and are a viable candidate for thermoelectrically cooled detectors. Experimental dark current -voltage (I-V) characteristics between 120 K and 300 K were fitted using numerical simulations. By fitting the temperature-dependent I-V experimental data, we determined that the observed negative differential resistance (NDR) is due to Auger suppression. More specifically, NDR is attributed to full suppression of Auger-1 processes and partial (similar to 70%) suppression of Auger-7 processes. After Auger suppression, the remaining leakage current is principally limited by the Shockley-Read-Hall recombination component. Part of the leakage current is also due to a residual Auger-7 current in the absorber due to the extrinsic p-type doping level. Analysis and comparison of our theoretical and experimental device results in structures where Auger suppression was realized are also presented. C1 [Velicu, S.; Grein, C. H.] EPIR Technol, Bolingbrook, IL 60440 USA. [Emelie, P. Y.; Itsuno, A.; Philips, J. D.] Univ Michigan, Ann Arbor, MI 48109 USA. [Wijewarnasuriya, P.] USA, Res Lab, Adelphi, MD 20783 USA. RP Velicu, S (reprint author), EPIR Technol, 590 Territorial Dr,Unit B, Bolingbrook, IL 60440 USA. EM svelicu@epir.com RI Phillips, Jamie/E-9394-2010 NR 24 TC 14 Z9 14 U1 3 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 873 EP 881 DI 10.1007/s11664-010-1218-0 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600009 ER PT J AU Itsuno, AM Emelie, PY Phillips, JD Velicu, S Grein, CH Wijewarnasuriya, PS AF Itsuno, A. M. Emelie, P. Y. Phillips, J. D. Velicu, S. Grein, C. H. Wijewarnasuriya, P. S. TI Arsenic Diffusion Study in HgCdTe for Low p-Type Doping in Auger-Suppressed Photodiodes SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Arsenic; HgCdTe; diffusion coefficient; low doping concentration; high operating temperature; infrared detector ID MERCURY CADMIUM TELLURIDE; INFRARED PHOTODIODES; DOPED HGCDTE; ACTIVATION; MBE; INTERDIFFUSION; PRESSURE; ALLOYS; GROWTH AB Controllable p-type doping at low concentrations is desired for multilayer HgCdTe samples in a P(+)/pi/N(+) structure due to the promise of suppressing Auger processes, and ultimately reduced dark current for infrared detectors operating at a given temperature. In this study, a series of arsenic implantation and annealing experiments have been conducted to study diffusion at low Hg partial pressure with the goal of achieving effective control over dopant profiles at low concentration. Arsenic dopant profiles were measured by secondary ion mass spectroscopy (SIMS), where diffusion coefficients were extracted with values ranging between 3.35 x 10(-16) cm(2) s(-1) and 6 x 10(-14) cm(2) s(-1). Arsenic diffusion coefficients were found to vary strongly with Hg partial pressure and HgCdTe alloy composition, corresponding to variations in Hg vacancy concentration. C1 [Itsuno, A. M.; Emelie, P. Y.; Phillips, J. D.] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Velicu, S.; Grein, C. H.] EPIR Technol, Bolingbrook, IL 60440 USA. [Wijewarnasuriya, P. S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Itsuno, AM (reprint author), Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. EM aitsuno@umich.edu RI Phillips, Jamie/E-9394-2010 NR 20 TC 5 Z9 6 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 945 EP 950 DI 10.1007/s11664-010-1157-9 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600019 ER PT J AU Jaime-Vasquez, M Jacobs, RN Benson, JD Stoltz, AJ Almeida, LA Bubulac, LO Chen, Y Brill, G AF Jaime-Vasquez, M. Jacobs, R. N. Benson, J. D. Stoltz, A. J. Almeida, L. A. Bubulac, L. O. Chen, Y. Brill, G. TI Evaluation of Surface Cleaning of Si(211) for Molecular-Beam Epitaxy Deposition of Infrared Detectors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE CdTe; HgCdTe; Si(211); tail distribution; molecular-beam epitaxy (MBE); x-ray photoelectron spectroscopy (XPS); scanning Auger microscopy (SAM); ion scattering spectroscopy (ISS) ID SCANNING-TUNNELING-MICROSCOPY; TERMINATED SI(100) SURFACES; INDEX SI SURFACES; HYDROGEN TERMINATION; SILICON SURFACES; SI(111) SURFACE; ETCHING SOLUTIONS; SPECTROSCOPY; DESORPTION; MONOHYDRIDE AB We report an assessment of the reproducibility of the HF cleaning process and As passivation prior to the nucleation of ZnTe on the Si(211) surface using temperature desorption spectroscopy, ion scattering spectroscopy, and electron spectroscopy. Observations suggest full H coverage of the Si(211) surface with mostly monohydride and small amounts of dihydride states, and that F is uniformly distributed across the top layer as a physisorbed species. Variations in major contaminants are observed across the Si surface and at the CdTe-ZnTe/Si interface. Defects act as getters for impurities present on the Si surface, and some are buried under the CdTe/ZnTe heterostructure. Overall, the data show evidence of localized concentration of major impurities around defects, supporting the hypothesis of a physical model explaining the electrical activation of defects in long-wave infrared (LWIR) HgCdTe/CdTe/Si devices. C1 [Jaime-Vasquez, M.; Jacobs, R. N.; Benson, J. D.; Stoltz, A. J.; Almeida, L. A.; Bubulac, L. O.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Chen, Y.; Brill, G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Jaime-Vasquez, M (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM info@nvl.army.mil RI Brill, Gregory/G-4877-2013 NR 32 TC 9 Z9 10 U1 2 U2 10 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 951 EP 957 DI 10.1007/s11664-010-1152-1 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600020 ER PT J AU Stoltz, AJ Benson, JD Smith, PJ AF Stoltz, A. J. Benson, J. D. Smith, P. J. TI Effects of HgCdTe on the Optical Emission of Inductively Coupled Plasmas SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Optical characterization; optoelectronic materials; photovoltaic materials; semiconductor processing; II-VI semiconductors ID CYCLOTRON-RESONANCE PLASMAS; WAVELENGTH; HG1-XCDXTE; CH4/H-2/AR; DETECTORS; SURFACE; ARRAYS; CDZNTE; CDTE AB Inductively coupled plasmas (ICP) are the high-density plasmas of choice for processing HgCdTe and related compounds. Real-time examination of the ICP plasmas used to process HgCdTe would be desirable. In this preliminary study, the feasibility of using optical emission spectroscopy (OES) of ICP plasma used for processing HgCdTe has been examined. We have examined the utility of OES as a real-time diagnostic tool for HgCdTe device fabrication. In this preliminary study it has been found that mercury and cadmium can be detected but are dependent on several factors: sample area, material composition, etch rate, sample temperature, photoresist area, and plasma power. Furthermore, we found strong correlation between the amount of hydrogen detected by OES for samples with photoresist versus samples without photoresist while processing with hydrogen-based plasma. Hydrogen emission intensity decreased dramatically in samples with photoresist, contrary to the theory that photoresist adds hydrogen to the plasma effluent. It appears that hydrogen complexes with photoresist, reducing the global amount of hydrogen during the process. Furthermore, this phenomena may help to explain macroloading issues whereby additional photoresist area slowed HgCdTe, CdTe, and photoresist etch rates. C1 [Stoltz, A. J.; Benson, J. D.; Smith, P. J.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. RP Stoltz, AJ (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. EM andrew.stoltz@nvl.army.mil NR 18 TC 3 Z9 3 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 958 EP 966 DI 10.1007/s11664-010-1147-y PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600021 ER PT J AU Brill, G Farrell, S Chen, YP Wijewarnasuriya, PS Rao, MV Benson, JD Dhar, N AF Brill, G. Farrell, S. Chen, Y. P. Wijewarnasuriya, P. S. Rao, Mulpuri V. Benson, J. D. Dhar, N. TI Dislocation Reduction of HgCdTe/Si Through Ex Situ Annealing SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Mercury; cadmium; telluride; HgCdTe; thermal cycle annealing; (112); etch pit density (EPD); dislocations; MBE; silicon; Si; composite substrates ID MOLECULAR-BEAM EPITAXY; INFRARED HGCDTE; MBE GROWTH; DETECTORS; SILICON; PERFORMANCE; GAAS AB Current growth methods of HgCdTe/Cd(Se)Te/Si by molecular-beam epitaxy (MBE) result in a dislocation density of mid 10(6) cm(-2) to low 10(7) cm(-2). Although the exact mechanism is unknown, it is well accepted that this high level of dislocation density leads to poorer long-wavelength infrared (LWIR) focal-plane array (FPA) performance, especially in terms of operability. We have conducted a detailed study of ex situ cycle annealing of HgCdTe/Cd(Se) Te/Si material in order to reduce the total number of dislocations present in as-grown material. We have successfully and consistently shown a reduction of one half to one full order of magnitude in the number of dislocations as counted by etch pit density (EPD) methods. Additionally, we have observed a corresponding decrease in x-ray full-width at half-maximum (FWHM) of ex situ annealed HgCdTe/Si layers. Among all parameters studied, the total number of annealing cycles seems to have the greatest impact on dislocation reduction. Currently, we have obtained numerous HgCdTe/Si layers which have EPD values measuring similar to 1 x 10(6) cm(-2) after completion of thermal cycle annealing. Preliminary Hall measurements indicate that electrical characteristics of the material can be maintained. C1 [Brill, G.; Chen, Y. P.; Wijewarnasuriya, P. S.; Dhar, N.] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Farrell, S.; Rao, Mulpuri V.] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA. [Benson, J. D.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Dhar, N.] MTO Off, DARPA, Arlington, VA 22203 USA. RP Brill, G (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gbrill@arl.army.mil RI Brill, Gregory/G-4877-2013 NR 23 TC 17 Z9 19 U1 0 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 967 EP 973 DI 10.1007/s11664-010-1142-3 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600022 ER PT J AU D'Souza, AI Stapelbroek, MG Wijewarnasuriya, PS AF D'Souza, A. I. Stapelbroek, M. G. Wijewarnasuriya, P. S. TI Monte Carlo Modeling of VLWIR HgCdTe Interdigitated Pixel Response SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Monte Carlo modeling; VLWIR HgCdTe; interdigitated pixel ID PHOTOVOLTAIC DETECTORS AB Increasing very long-wave infrared (VLWIR, lambda(c) approximate to 15 mu m) pixel operability was approached by subdividing each pixel into four interdigitated subpixels. High response is maintained across the pixel, even if one or two interdigitated subpixels are deselected (turned off), because interdigitation provides that the preponderance of minority carriers photogenerated in the pixel are collected by the selected subpixels. Monte Carlo modeling of the photoresponse of the interdigitated subpixel simulates minority-carrier diffusion from carrier creation to recombination. Each carrier generated at an appropriately weighted random location is assigned an exponentially distributed random lifetime si, where is the bulk minority-carrier lifetime. The minority carrier is allowed to diffuse for a short time d tau, and the fate of the carrier is decided from its present position and the boundary conditions, i.e., whether the carrier is absorbed in a junction, recombined at a surface, reflected from a surface, or recombined in the bulk because it lived for its designated lifetime. If nothing happens, the process is then repeated until one of the boundary conditions is attained. The next step is to go on to the next carrier and repeat the procedure for all the launches of minority carriers. For each minority carrier launched, the original location and boundary condition at fatality are recorded. An example of the results from Monte Carlo modeling is that, for a 20-mu m diffusion length, the calculated quantum efficiency (QE) changed from 85% with no subpixels deselected, to 78% with one subpixel deselected, 67% with two subpixels deselected, and 48% with three subpixels deselected. Demonstration of the interdigitated pixel concept and verification of the Monte Carlo modeling utilized lambda(c)(60 K) approximate to 15 mu m HgCdTe pixels in a 96 x 96 array format. The measured collection efficiency for one, two, and three subelements selected, divided by the collection efficiency for all four subelements selected, matched that calculated using Monte Carlo modeling. C1 [D'Souza, A. I.; Stapelbroek, M. G.] DRS Technol, Calif Div, Cypress, CA 90630 USA. [Wijewarnasuriya, P. S.] USA, Res Lab, Adelphi, MD 20783 USA. RP D'Souza, AI (reprint author), DRS Technol, Calif Div, 10600 Valley View St, Cypress, CA 90630 USA. EM arvind.d'souza@drs-sts.com NR 15 TC 0 Z9 1 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 986 EP 991 DI 10.1007/s11664-010-1122-7 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600025 ER PT J AU Rao, SR Shintri, SS Markunas, JK Jacobs, RN Bhat, IB AF Rao, S. R. Shintri, S. S. Markunas, J. K. Jacobs, R. N. Bhat, I. B. TI Cyclic Annealing During Metalorganic Vapor-Phase Epitaxial Growth of (211)B CdTe on (211) Si Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE MOVPE; (211) orientation; CdTe; silicon; germanium; ZnTe; arsenic; thermal cycling ID MOLECULAR-BEAM EPITAXY; HETEROEPITAXY; PERFORMANCE; ZNTE AB High-quality (211) B CdTe buffer layers on Si substrates are required to enable Hg(1-x)Cd(x)Te growth and device fabrication on lattice-mismatched Si substrates. Metalorganic vapor-phase epitaxy (MOVPE) of (211) B CdTe on Si substrates using Ge and ZnTe interlayers has been achieved. Cyclic annealing has been used during growth of thick CdTe layers in order to improve crystal quality. The best (211) B CdTe/Si films grown in this study display a low x-ray diffraction (XRD) rocking-curve full-width at half-maximum (FWHM) of 85 arcsec and etch pit density (EPD) of 2 x 10(6) cm(-2). These values are the best reported for MOVPE-grown (211) CdTe/Si and are comparable to those for state-of-the-art molecular beam epitaxy (MBE)-grown CdTe/Si. C1 [Rao, S. R.; Shintri, S. S.; Bhat, I. B.] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Markunas, J. K.; Jacobs, R. N.] USA, RDECOM CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Rao, SR (reprint author), Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, 110 8th St, Troy, NY 12180 USA. EM raos@rpi.edu NR 17 TC 8 Z9 8 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 996 EP 1000 DI 10.1007/s11664-010-1095-6 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600027 ER PT J AU Jacobs, RN Smith, PJ Markunas, JK Benson, JD Pellegrino, J AF Jacobs, R. N. Smith, P. J. Markunas, J. K. Benson, J. D. Pellegrino, J. TI Feasibility of Localized Substrate Thinning for Reduced Dislocation Density in CdTe/Si Heterostructures SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Wafer thinning; threading dislocation density; mismatched heteroepitaxy; silicon; HgCdTe; CdTe; image force ID CRITICAL THICKNESS; EPITAXIAL-GROWTH; SI; HGCDTE; HETEROEPITAXY; REDUCTION AB HgCdTe heteroepitaxy on low-cost, large-lattice-mismatched substrates such as Si continue to be plagued by large threading dislocation densities that ultimately reduce the operability of the thermal imaging detector array. Molecular-beam epitaxy (MBE) of 10 mu m-to 15 mu m-thick CdTe buffer layers has played a crucial role in reducing dislocation densities to current state-of-theart levels. Herein, we examine the possibility that growth on locally back-thinned substrates could prove advantageous in further reducing dislocation densities in the CdTe/Si heteroepitaxial system. Using defect decoration techniques, a decrease in dislocation (etch-pit) density of up to similar to 42% has been measured in CdTe regions where the underlying Si substrate was chemically back-thinned to similar to 20 mu m. A theoretical understanding is proposed, where a substrate-thickness-dependent dislocation image force is a likely cause for the experimentally observed reduction in threading dislocation density. These observations raise the prospect of combining localized substrate thinning with other techniques to further reduce dislocation densities to levels sought for HgCdTe/CdTe/Si and other large-lattice-mismatched systems. C1 [Jacobs, R. N.; Smith, P. J.; Markunas, J. K.; Benson, J. D.; Pellegrino, J.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Jacobs, RN (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM info@nvl.army.mil NR 21 TC 4 Z9 4 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 1036 EP 1042 DI 10.1007/s11664-010-1085-8 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600034 ER PT J AU de Lyon, TJ Rajavel, RD Nosho, BZ Terterian, S Beliciu, ML Patterson, PR Chang, DT Boag-O'Brien, MF Holden, BT Jacobs, RN Benson, JD AF de Lyon, T. J. Rajavel, R. D. Nosho, B. Z. Terterian, S. Beliciu, M. L. Patterson, P. R. Chang, D. T. Boag-O'Brien, M. F. Holden, B. T. Jacobs, R. N. Benson, J. D. TI MBE Growth and Transfer of HgCdTe Epitaxial Films from InSb Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE HgCdTe; InSb; detectors; photodiodes; molecular-beam epitaxy (MBE); heteroepitaxy; wafer bonding ID WAFERS AB An investigation of the heteroepitaxial growth of HgCdTe films onto InSb(211) B substrates is reported. High-quality HgCdTe(211) B single-crystal films have been successfully deposited onto InSb(211) B substrates and have been characterized with x-ray diffraction rocking curve analysis, etch pit density analysis, and surface void defect mapping. X-ray rocking curve (422) reflection full-width at half-maximum of 60 arcsec has been obtained for 7-mu m-thick x = 0.22 HgCdTe epitaxial films, and etch pit densities of 3 x 10(6) cm(-2) to 3 x 10(7) cm(-2) have been observed. A significant reduction in HgCdTe void defect densities to 100 cm(-2) to 200 cm(-2) has been observed on InSb, including a complete absence of large "void cluster'' defects that are often observed for growth on CdZnTe. Wafer bow induced by the growth of HgCdTe on InSb is less than 1 mu m for 2-inch-diameter substrates. Significant diffusion of In into HgCdTe is observed for HgCdTe/InSb wafers that are subjected to Hg anneals at 250 degrees C to 300 degrees C. A preliminary investigation of the transfer of HgCdTe films from InSb onto Si substrates has also been undertaken, using an adhesive wafer bonding approach evaluated with scanning acoustic microscopy. The infrared transmission characteristics of the bonding adhesive have been investigated with respect to postgrowth annealing procedures to establish the compatibility of the bonding approach with HgCdTe device processing and detector operation. C1 [de Lyon, T. J.; Rajavel, R. D.; Nosho, B. Z.; Terterian, S.; Beliciu, M. L.; Patterson, P. R.; Chang, D. T.; Boag-O'Brien, M. F.; Holden, B. T.] HRL Labs LLC, Malibu, CA 90265 USA. [Jacobs, R. N.; Benson, J. D.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. RP de Lyon, TJ (reprint author), HRL Labs LLC, 3011 Malibu Canyon Rd, Malibu, CA 90265 USA. EM tjdelyon@HRL.com NR 9 TC 6 Z9 6 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 1058 EP 1062 DI 10.1007/s11664-009-1041-7 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600037 ER PT J AU Ciani, AJ Chung, PW AF Ciani, Anthony J. Chung, Peter W. TI Simulations of Dislocations in CdZnTe/SL/Si Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Discrete dislocation dynamics; superlattice; mercury cadmium telluride; cadmium zinc telluride; cadmium telluride; HgCdTe; CdZnTe; CdTe; silicon; Si ID MISFIT-DISLOCATION; INFRARED HGCDTE; BUFFER LAYERS; SUPERLATTICES; REDUCTION; SILICON; STRESS; GROWTH; ARRAYS; FILMS AB Discrete dislocation dynamics simulations were employed to study the primary mechanisms by which superlattices (SLs) block threading dislocations (TDs) from reaching the surface of a composite CdZnTe/SL/Si substrate. We found that the difference in strain (composition) across layer boundaries played a key role as to whether a TD might veer away or continue across. We also found that, while the distance between interfaces had little effect on the motion of a single TD, it could have an impact on the dislocation tangle as a whole and should be considered carefully in SL design. We discuss our results in relation to the design of SLs for TD blocking. C1 [Ciani, Anthony J.; Chung, Peter W.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Ciani, AJ (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM anthony.j.ciani@arl.army.mil NR 29 TC 3 Z9 3 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 1063 EP 1069 DI 10.1007/s11664-009-1039-1 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600038 ER PT J AU Aifer, EH Warner, JH Canedy, CL Vurgaftman, I Jackson, EM Tischler, JG Meyer, JR Powell, SP Olver, K Tennant, WE AF Aifer, E. H. Warner, J. H. Canedy, C. L. Vurgaftman, I. Jackson, E. M. Tischler, J. G. Meyer, J. R. Powell, S. P. Olver, K. Tennant, W. E. TI Shallow-Etch Mesa Isolation of Graded-Bandgap "W''-Structured Type II Superlattice Photodiodes SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE Type II superlattice; antimonide; GaSb; infrared detector AB Shallow-etch mesa isolation (SEMI) of graded-bandgap "W''-structured type II superlattice (GGW) infrared photodiodes provides a powerful means for reducing excess dark currents due to surface and bulk junction related processes, and it is particularly well suited for focal-plane array fabrication. In the n-on-p GGW photodiode structure the energy gap is increased in a series of steps from that of the lightly p-type infrared-absorbing region to a value typically two to three times larger. The wider gap levels off about 10 nm short of the doping-defined junction, and continues for another 0.25 mu m into the heavily n-doped cathode before the structure is terminated by an n(+)-doped InAs top cap layer. The increased bandgap in the high-field region near the junction helps to strongly suppress both bulk tunneling and generation-recombination (G-R) current by imposing a much larger tunneling barrier and exponentially lowering the intrinsic carrier concentration. The SEMI approach takes further advantage of the graded structure by exposing only the widest-gap layers on etched surfaces. This lowers surface recombination and trap-assisted tunneling in much the same way as the GGW suppresses these processes in the bulk. Using SEMI, individual photodiodes are defined using a shallow etch that typically terminates only 10 nm to 20 nm past the junction, which is sufficient to isolate neighboring pixels while leaving the narrow-gap absorber layer buried 100 nm to 200 nm below the surface. This provides for separate optimization of the photodiode's electrical and optical area. The area of the junction can be reduced to a fraction of that of the pixel, lowering bulk junction current, while maintaining 100% optical fill factor with the undisturbed absorber layer. Finally, with the elimination of deep, high-aspect-ratio trenches, SEMI simplifies array fabrication. We report herein results from SEMI-processed GGW devices, including large-area discrete photodiodes, mini-arrays, and a focal-plane array. Current-voltage data show strong suppression of side-wall leakage relative to that for more deeply etched devices, as well as scaling of dark current with junction area without loss of quantum efficiency. C1 [Aifer, E. H.; Warner, J. H.; Canedy, C. L.; Vurgaftman, I.; Jackson, E. M.; Tischler, J. G.; Meyer, J. R.] USN, Res Lab, Washington, DC 20375 USA. [Powell, S. P.] N Carolina State Univ, Raleigh, NC 27695 USA. [Olver, K.] USA, Res Lab, Adelphi, MD 20783 USA. [Tennant, W. E.] Teledyne Imaging Sensors, Camarillo, CA 93212 USA. RP Aifer, EH (reprint author), USN, Res Lab, Washington, DC 20375 USA. EM edward.aifer@nrl.navy.mil NR 19 TC 21 Z9 21 U1 1 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 1070 EP 1079 DI 10.1007/s11664-009-1056-0 PG 10 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600039 ER PT J AU Benson, JD Bubulac, LO Smith, PJ Jacobs, RN Markunas, JK Jaime-Vasquez, M Almeida, LA Stoltz, AJ Wijewarnasuriya, PS Brill, G Chen, Y Lee, U Vilela, MF Peterson, J Johnson, SM Lofgreen, DD Rhiger, D Patten, EA Goetz, PM AF Benson, J. D. Bubulac, L. O. Smith, P. J. Jacobs, R. N. Markunas, J. K. Jaime-Vasquez, M. Almeida, L. A. Stoltz, A. J. Wijewarnasuriya, P. S. Brill, G. Chen, Y. Lee, U. Vilela, M. F. Peterson, J. Johnson, S. M. Lofgreen, D. D. Rhiger, D. Patten, E. A. Goetz, P. M. TI Characterization of Dislocations in (112)B HgCdTe/CdTe/Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE HgCdTe/CdTe/Si; molecular beam epitaxy; atomic force microscopy; electrostatic force microscopy; etch pit density ID MOLECULAR-BEAM EPITAXY; DIODE PERFORMANCE; HGCDTE; GROWTH; SILICON; SURFACE; SI AB The electrical performance of HgCdTe/Si photodiodes is shown not to have a direct relationship with the dislocation density as revealed by defect etching. This has led to an equivalent circuit model to explain the relationship of the dislocation density and the electrical test data. A new (112)B HgCdTe/CdTe/Si and CdTe/Si etch pit density (EPD) etch has been demonstrated. The new etch has been used to look for distinctive features which may be responsible for the poor electrical performance of individual diode pixels. The new etch chemistry also reduces the surface roughness of the etched epilayer and makes EPD determination less problematic. The new (to HgCdTe) technique of electrostatic force microscopy has also been used to analyze the electrical properties of dislocations. C1 [Benson, J. D.; Bubulac, L. O.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Jaime-Vasquez, M.; Almeida, L. A.; Stoltz, A. J.] USA, RDECOM, CERDEC Night Vis & Elect Sensors, Ft Belvoir, VA USA. [Wijewarnasuriya, P. S.; Brill, G.; Chen, Y.; Lee, U.] USA, Res Lab, Adelphi, MD USA. [Vilela, M. F.; Peterson, J.; Johnson, S. M.; Lofgreen, D. D.; Rhiger, D.; Patten, E. A.; Goetz, P. M.] Raytheon Vis Syst, Goleta, CA USA. RP Benson, JD (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors, Ft Belvoir, VA USA. EM david.j.benson@us.army.mil RI Brill, Gregory/G-4877-2013 NR 25 TC 18 Z9 18 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 1080 EP 1086 DI 10.1007/s11664-010-1262-9 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600040 ER PT J AU Wijewarnasuriya, P Chen, YP Brill, G Dhar, N Benson, D Bubulac, L Edwall, D AF Wijewarnasuriya, Priyalal Chen, Yuanping Brill, Greg Dhar, Nibir Benson, David Bubulac, Lucia Edwall, Dennis TI Analysis of Current-Voltage Measurements on Long-Wavelength HgCdTe Photodiodes Fabricated on Si Composite Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 28th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 06-08, 2009 CL Chicago, IL SP USA CECOM Night Vis & Elect Sensors Directorate, USA Res Lab, USA SMDC, US Navy Electro Opt Ctr, Penn State Appl Res Lab, Off Naval Res, Air Force Res Lab, Minerals, Met & Mat Soc DE HgCdTe; Si; curent-voltage; band-to-band tunneling; shunt; trap-assisted tunneling ID BEAM EPITAXIAL-GROWTH; PHOTOVOLTAIC DETECTORS; MBE GROWTH; TEMPERATURE; PERFORMANCE; CDZNTE/SI; QUALITY; DEFECTS; SI(211); SILICON AB We have performed a detailed study of dark current versus voltage to understand existing limitations in dark current and address the nonuniformity of dark current in devices fabricated on HgCdTe grown on silicon substrates. One interesting observation is that trap-assisted tunneling, g-r currents, are not found close to zero bias in certain devices. Devices from the low end of the R(0)A distribution show heavy shunting paths close to zero bias. We believe that these shunting paths may be the limiting cause of tail distributions in fabricated focal plane array tail distributions. Possible causes for these shunting paths are surface charges associated with dislocation cores and impurity gettering at dislocation cores. The measured non-anti-reflection (AR)-coated quantum efficiency (QE) was 0.576 at 78 K and displays the classical response versus wavelength. The measured QE on isolated single devices is consistent with the 256 x 256 focal-plane array mean QE. Obtained average dark currents are on the order of mid 10(-5) A cm(-2), which is one order of magnitude higher than dark currents obtained from arrays on lattice-matched substrates. On average, arrays on lattice-mismatched substrates show performance characteristics inferior to those of arrays fabricated on lattice-matched substrates. This inferior performance is due to array pixel operability, as can be seen from the tail of the distribution and the average dark currents, which are one order of magnitude higher than those obtained on lattice-matched substrates. C1 [Wijewarnasuriya, Priyalal; Chen, Yuanping; Brill, Greg; Dhar, Nibir] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. [Dhar, Nibir] MTO Off, DARPA, Arlington, VA 22203 USA. [Benson, David; Bubulac, Lucia] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Edwall, Dennis] Teledyne Sci & Imaging, Camarillo, CA 93012 USA. RP Wijewarnasuriya, P (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM priyalal.wijewarnasuriya@us.army.mil RI Brill, Gregory/G-4877-2013 NR 23 TC 6 Z9 6 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 2010 VL 39 IS 7 BP 1110 EP 1117 DI 10.1007/s11664-010-1257-6 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 620MS UT WOS:000279504600044 ER PT J AU Chen, RH Speyer, JL Lianos, D AF Chen, Robert H. Speyer, Jason L. Lianos, Dimitrios TI Optimal Intercept Missile Guidance Strategies with Autopilot Lag SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article; Proceedings Paper CT AIAA Guidance, Navigation and Control Conference CY AUG 20-23, 2007 CL Hilton Head Isl, SC ID ACCELERATION AB In the linear-quadratic pursuit-evasion game, the pursuer (interceptor) wishes to minimize the terminal miss, whereas the evader (target) wishes to maximize it. Therefore, the optimal strategy of the interceptor is derived against the anticipated worst possible strategy of the target. If the interceptor has a lag, the current approach is to include this lag directly in the system dynamics, which are known to both players. In this problem formulation, the optimal cost could easily go to infinity, which means that the target will win the game. This is expected, because the target has knowledge about interceptor's lag. To ensure the existence of an interceptor strategy, the weighting on the terminal miss has to be chosen small enough so that the optimal cost will remain finite. However, this manipulation prevents the target from maximizing the terminal miss and effectively constrains the target strategy. Therefore, the interceptor strategy is derived against the worst-case target strategy that is not really the worst case. In this paper, it is shown that this interceptor strategy performs poorly in realistic situations where the target tries to maximize the terminal miss. Instead, two new interceptor strategies are derived against target strategies that are determined without knowledge about the interceptor's lag. These two optimal interceptor strategies improve the game-theoretic guidance law for homing missiles by correctly taking into account the autopilot lag. C1 [Chen, Robert H.] Northrop Grumman Corp, Aerosp Syst Sector, El Segundo, CA 90245 USA. [Speyer, Jason L.] SySense Inc, El Segundo, CA 90245 USA. [Lianos, Dimitrios] USA, Res Dev & Engn Command, Missile Res Dev & Engn Ctr, Huntsville, AL 35806 USA. RP Chen, RH (reprint author), Northrop Grumman Corp, Aerosp Syst Sector, El Segundo, CA 90245 USA. NR 16 TC 8 Z9 20 U1 1 U2 12 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD JUL-AUG PY 2010 VL 33 IS 4 BP 1264 EP 1272 DI 10.2514/1.44618 PG 9 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 625IT UT WOS:000279889400021 ER PT J AU Paranavitana, C Zelazowska, E DaSilva, L Pittman, PR Nikolich, M AF Paranavitana, Chrysanthi Zelazowska, Elzbieta DaSilva, Luis Pittman, Phillip R. Nikolich, Mikeljon TI Th17 Cytokines in Recall Responses Against Francisella Tularensis in Humans SO JOURNAL OF INTERFERON AND CYTOKINE RESEARCH LA English DT Article ID T-CELLS; TULAREMIA VACCINE; IMMUNE-RESPONSE; CD4(+); IL-17; INTERLEUKIN-17; CHALLENGE; DISTINCT; LINEAGE; LIVE AB To determine whether cytokines and T-cell subsets other than Th1 cells contribute to secondary immune responses against Francisella species, we investigated production of Th17-associated cytokines IL-17 and IL-22 in a recall response to Francisella tularensis. Peripheral blood mononuclear cells (PBMCs) from volunteers previously immunized with the F. tularensis live vaccine strain (LVS) were stimulated in vitro with bacterial lysates of LVS or a nonpathogenic type A B38 strain. Gene expression analysis by real-time PCR showed that IL-17 and IL-22 transcripts were induced in immune PBMCs at a significantly higher level than in cells from nonvaccinated volunteers stimulated with LVS or B38 antigens at 24 h. In addition, we detected both cell-associated and secreted IL-22 at 24 h after stimulation and IL-17 at 72 h post-stimulation. Intracellular IL-22 and IL-17 were observed in memory CD4+ cells and less in memory CD8+ cells. These findings suggest that Th17 responses in addition to the Th1 response may play an important role in adaptive immunity against Francisella. C1 [Paranavitana, Chrysanthi; Zelazowska, Elzbieta; Nikolich, Mikeljon] WRAIR, Dept Dangerous Bacterial Pathogens, Silver Spring, MD 20190 USA. [Pittman, Phillip R.] USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA. [DaSilva, Luis] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. RP Paranavitana, C (reprint author), WRAIR, Dept Dangerous Bacterial Pathogens, 503 Robert Grant Ave, Silver Spring, MD 20190 USA. EM chrysanthi.paranavitana@amedd.army.mil RI Nikolich, Mikeljon/B-2868-2011 FU Defense Threat Reduction Agency (DTRA) of the Department of Defense FX We thank Andrew LaClair for excellent technical assistance in performing ELISAs. We also thank Dr. Manmohan Ranadive, Mr. Lawrence Korman, Ms. Aimee Porter, and Ms. Rebecca Erwin-Cohen for the help with Human Use protocol and collection of blood samples and Ms. Jennifer Secula for help editing this manuscript. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, the Department of the Air Force, or the Department of Defense. This work was supported by a grant to Dr. Chrysanthi Paranavitana from the Defense Threat Reduction Agency (DTRA) of the Department of Defense. NR 28 TC 13 Z9 13 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1079-9907 J9 J INTERF CYTOK RES JI J. Interferon Cytokine Res. PD JUL PY 2010 VL 30 IS 7 BP 471 EP 476 DI 10.1089/jir.2009.0108 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA 624VU UT WOS:000279850900003 PM 20626289 ER PT J AU Chon, TW Bixler, S AF Chon, Thomas W. Bixler, Sandra TI Interferon-tau: Current Applications and Potential in Antiviral Therapy SO JOURNAL OF INTERFERON AND CYTOKINE RESEARCH LA English DT Review ID OVINE TROPHOBLAST PROTEIN-1; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; 2',5'-OLIGOADENYLATE SYNTHETASE-ACTIVITY; IMMUNODEFICIENCY-VIRUS ACTIVITY; PREGNANCY RECOGNITION HORMONE; IFN-TAU; CHROMOSOMAL LOCALIZATION; 2-5-OLIGOADENYLATE SYNTHETASE; TYPE-1 INTERFERON; HUMAN MACROPHAGES AB Interferon-tau (IFN-tau) was initially identified as an ovine pregnancy protein. Produced by the trophoblast, it is important in preventing degradation of the corpus luteum and has been used as an early marker for ovine pregnancy. As a member of the family of type I interferons, IFN-tau has demonstrated promising antiviral activity against human viral infections in vitro. Additionally, it displays high species cross-reactivity despite its absence in humans. To date, IFN-tau has shown efficacy in reducing replication of human immunodeficiency virus, feline immunodeficiency virus, and human papillomavirus. While IFN-tau shares similar antiviral activity to IFN-alpha, the current interferon of choice for treatment of viral infections, it lacks the associated toxicity. This may make IFN-tau an attractive alternative to IFN-alpha for the treatment of viral infections. C1 [Chon, Thomas W.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Bixler, Sandra] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. [Chon, Thomas W.] Walter Reed Army Inst Res, Dept Cellular & Mol Neurochem, Silver Spring, MD USA. RP Chon, TW (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM Thomas.Chon@Gmail.com NR 72 TC 8 Z9 11 U1 0 U2 7 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1079-9907 J9 J INTERF CYTOK RES JI J. Interferon Cytokine Res. PD JUL PY 2010 VL 30 IS 7 BP 477 EP 485 DI 10.1089/jir.2009.0089 PG 9 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA 624VU UT WOS:000279850900004 PM 20626290 ER PT J AU Grujicic, M Arakere, G Yalavarthy, HV He, T Yen, CF Cheeseman, BA AF Grujicic, M. Arakere, G. Yalavarthy, H. V. He, T. Yen, C. -F. Cheeseman, B. A. TI Modeling of AA5083 Material-Microstructure Evolution During Butt Friction-Stir Welding SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE AA5083; finite element analysis; friction stir welding; Johnson-Cook strength model ID MATERIAL FLOW; ALUMINUM-ALLOYS; THERMAL HISTORY; NANOCRYSTALLINE FERRITE; MECHANICAL-PROPERTIES; 3-DIMENSIONAL HEAT; PLASTIC-FLOW; SIMULATION; STRESSES; RECRYSTALLIZATION AB A concise yet a fairly comprehensive overview of the friction stir welding (FSW) process is provided. This is followed by a computational investigation in which FSW behavior of a prototypical solution-strengthened and strain-hardened aluminum alloy, AA5083-H131, is modeled using a fully coupled thermo-mechanical finite-element procedure developed in our prior study. Particular attention is given to proper modeling of the welding work-piece material behavior during the FSW process. Specifically, competition and interactions between plastic-deformation and dynamic-recrystallization processes are considered to properly account for the material-microstructure evolution in the weld nugget zone. The results showed that with proper modeling of the material behavior under high-temperature/severe-plastic-deformation conditions, significantly improved agreement can be attained between the computed and measured post-FSW residual-stress and material-strength distribution results. C1 [Grujicic, M.; Arakere, G.; Yalavarthy, H. V.; He, T.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Yen, C. -F.; Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University Cooperative Agreements [W911NF-04-2-0024, W911NF-06-2-0042] FX This research article is based on project with financial support under the U.S. Army/Clemson University Cooperative Agreements, W911NF-04-2-0024 and W911NF-06-2-0042. NR 44 TC 37 Z9 37 U1 3 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD JUL PY 2010 VL 19 IS 5 BP 672 EP 684 DI 10.1007/s11665-009-9536-1 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 629ZS UT WOS:000280240900011 ER PT J AU Wolfenstine, J AF Wolfenstine, J. TI Stability predictions of solid Li-ion conducting membranes in aqueous solutions SO JOURNAL OF MATERIALS SCIENCE LA English DT Letter ID AIR SECONDARY BATTERIES; LITHIUM INTERCALATION; ELECTROLYTES; WATER; ANODE C1 USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, RDRL SED C, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jwolfenstine@arl.army.mil NR 17 TC 8 Z9 8 U1 0 U2 19 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUL PY 2010 VL 45 IS 14 BP 3954 EP 3956 DI 10.1007/s10853-010-4522-4 PG 3 WC Materials Science, Multidisciplinary SC Materials Science GA 601AI UT WOS:000278029900033 ER PT J AU Cameron, EC Wilkerson, RC Mogi, M Miyagi, I Toma, T Kim, HC Fonseca, DM AF Cameron, Emilie C. Wilkerson, Richard C. Mogi, Motoyoshi Miyagi, Ichiro Toma, Takako Kim, Heung-Chul Fonseca, Dina M. TI Molecular Phylogenetics of Aedes japonicus, a Disease Vector That Recently Invaded Western Europe, North America, and the Hawaiian Islands SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE cytochrome oxidase II; nicotinamide adenine dinucleotide dehydrogenase subunit 4; ITS-D2 spacer; Aedes koreicus; Ochlerotatus japonicus ID OCHLEROTATUS-J.-JAPONICUS; ALLIED TAXA DIPTERA; ENCEPHALITIS-VIRUS; UNITED-STATES; LIFE STAGES; EXPERIMENTAL TRANSMISSION; MULTIPLE INTRODUCTIONS; POPULATION-GENETICS; MORPHOLOGICAL DATA; NILE-VIRUS AB We used two mitochondrial loci (nicotinamide adenine dinucleotide dehydrogenase subunit 4 and cytochrome oxidase II) and a nuclear locus (28S-D2 spacer) for a total of 1337 bp to evaluate the relationships among the four subspecies of Aedes (Finlaya) japonicus Theobald. Ae. j. japonicus was recently introduced into the United States and has been expanding rapidly. We also included in our analysis a morphologically very closely related species, Aedes (Finlaya) koreicus Edwards, as well as three more distantly related species: Aedes (Finlaya) togoi Theobald, Aedes (Finlaya) hatorii Yamada, and Aedes (Aedimorphus) vexans Meigen. We found that the four subspecies in the Ae. japonicus complex are genetically quite distinct but seem to form a monophyletic group that surprisingly also includes Ae. koreicus, suggesting the need for a taxonomic reconsideration of the group. We also found that the two southern subspecies are more closely related to each other than to any of the remaining subspecies or to Ae. koreicus and may indicate an ancient north-south split of the lineage. Considering the overlap between Ae. j. japonicus and Ae. koreicus, but the stronger association between Ae. koreicus and humans, we are surprised it also has not expanded from its original range. As a proactive reaction to this possibility, we designed and tested a DNA-based rapid assay to differentiate Ae. koreicus from some of the species with which it may be confused in the United States. These Aedes are putative vectors of several important viral encephalitides. C1 [Cameron, Emilie C.; Fonseca, Dina M.] Rutgers State Univ, Ctr Vector Biol, New Brunswick, NJ 08901 USA. [Wilkerson, Richard C.] Walter Reed Army Inst Res, Walter Reed Biosystemat Unit, Div Entomol, Silver Spring, MD 20910 USA. [Mogi, Motoyoshi] Saga Med Sch, Dept Microbiol, Saga 8498501, Japan. [Miyagi, Ichiro; Toma, Takako] Univ Ryukyus, Fac Med, Sch Hlth Sci, Lab Med Zool, Okinawa 9030215, Japan. [Kim, Heung-Chul] USA, Med Brigade 65, Multifunct Med Battal 168, Med Detachment 5, APO, AP 96205 USA. RP Fonseca, DM (reprint author), Rutgers State Univ, Ctr Vector Biol, 180 Jones Ave, New Brunswick, NJ 08901 USA. EM dinafons@rci.rutgers.edu OI Fonseca, Dina/0000-0003-4726-7100 FU WRATH; Smithsonian Institution; National Institutes of Health National Institute of Allergy and Infectious Disease [N01-AI25490] FX We thank all the researchers and mosquito control personnel that provided us with specimens for this research. Without their generosity our work would not have been possible. This material has been reviewed by the Walter Reed Army Institute of Research (WRAIR). There is no objection to its presentation and/or publication. This research was performed under a Memorandum of Understanding between WRATH and the Smithsonian Institution, with institutional support provided by both organizations. This project has been funded in part by Federal funds from the National Institutes of Health National Institute of Allergy and Infectious Disease, under contract N01-AI25490. This is New Jersey Agricultural Experiment Station publication D-08-08194-14-09. NR 61 TC 24 Z9 26 U1 1 U2 11 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2010 VL 47 IS 4 BP 527 EP 535 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 621AL UT WOS:000279545400003 PM 20695267 ER PT J AU Carroll, JF Benante, JP Kramer, M Lohmeyer, KH Lawrence, K AF Carroll, J. F. Benante, J. P. Kramer, M. Lohmeyer, K. H. Lawrence, K. TI Formulations of Deet, Picaridin, and IR3535 Applied to Skin Repel Nymphs of the Lone Star Tick (Acari: Ixodidae) for 12 Hours SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Amblyomma americanum; 12-h duration; human volunteers; repellents ID AMBLYOMMA-AMERICANUM ACARI; PERSONAL PROTECTION; IXODES-SCAPULARIS; FIELD-EVALUATION; LYME-DISEASE; PERMETHRIN; EFFICACY; HUMANS; ATTRACTION; AI3-37220 AB The efficacies of a 20% 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate (picaridin) spray, 20% 3-(N-acetyl-N-butyl) aminopropionic acid ethyl ester (IR3535) spray, 20% picaridin lotion, 10% IR3535 lotion, and 33% N,N-diethyl-3-methylbenzamide (deet) cream in repelling nymphal lone star ticks. Amblyomma americanum (L.), were determined at 2-h intervals over 12 h usinghuman subjects. A repellent formulation was applied in a 5-cm-wide encircling a volunteer's lower leg. For each challenge, 70 host-seeking nymphs were released on each volunteer's ankle, and tick locations were recorded 10 ruin after the ticks were released. Ticks that crawled entirely across the repellent band were considered not repelled. For all formulations and time points, significantly fewer (all P < 0.0001) A. americanum nymphs crossed the treatment bands on the volunteers' ankles than crossed the corresponding area on the untreated control legs. Formulations containing active ingredient were highly effective, with <10% of the ticks crossing through the treatment bands for any challenge during the 12 h. At least 40% of ticks exposed to any formulation for any challenge fell or crawled off the volunteers. There was no difference in effectiveness between the 20% spray and 20% lotion formulations of picaridin. The 10% IR3535 lotion was significantly less effective than the formulations with higher concentrations of repellent, In the formulations tested, deet, picaridin, and IR3535 provided lasting protection against A. americanum. C1 [Benante, J. P.; Lawrence, K.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Kramer, M.] ARS, USDA, Biometr Consulting Serv, Agr Res Ctr, Beltsville, MD 20705 USA. [Lohmeyer, K. H.] ARS, USDA, Knipling Bushland US Livestock Insects Res Lab, Kerrville, TX 78028 USA. [Carroll, J. F.] ARS, USDA, Invas Insect Biocontrol & Behav Lab, Agr Res Ctr, Beltsville, MD 20705 USA. RP Carroll, JF (reprint author), ARS, USDA, Invas Insect Biocontrol & Behav Lab, Agr Res Ctr, Beltsville, MD 20705 USA. EM john.carroll@ars.usda.gov NR 32 TC 12 Z9 13 U1 0 U2 9 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2010 VL 47 IS 4 BP 699 EP 704 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 621AL UT WOS:000279545400024 PM 20695288 ER PT J AU Qiu, Z Pulskamp, JS Lin, XK Rhee, CH Wang, T Polcawich, RG Oldham, K AF Qiu, Zhen Pulskamp, Jeffrey S. Lin, Xianke Rhee, Choong-Ho Wang, Thomas Polcawich, Ronald G. Oldham, Kenn TI Large displacement vertical translational actuator based on piezoelectric thin films SO JOURNAL OF MICROMECHANICS AND MICROENGINEERING LA English DT Article ID CONFOCAL MICROSCOPE; MICROACTUATOR; DESIGN; FABRICATION; SCANNER; STROKE; SWITCH AB A novel vertical translational microactuator based on thin-film piezoelectric actuation is presented, using a set of four compound bend-up/bend-down unimorphs to produce translational motion of a moving platform or stage. The actuation material is a chemical-solution deposited lead-zirconate-titanate (PZT) thin film. Prototype designs have shown as much as 120 mu m of static displacement, with 80-90 mu m displacements being typical, using four 920 mu m long by 70 mu m legs. Analytical models are presented that accurately describe nonlinear behavior in both static and dynamic operation of prototype stages when the dependence of piezoelectric coefficients on voltage is known. Resonance of the system is observed at a frequency of 200 Hz. The large displacement and high bandwidth of the actuators at low-voltage and low-power levels should make them useful to a variety of optical applications, including endoscopic microscopy. C1 [Lin, Xianke; Rhee, Choong-Ho; Oldham, Kenn] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Qiu, Zhen; Wang, Thomas] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA. [Pulskamp, Jeffrey S.; Polcawich, Ronald G.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20873 USA. RP Oldham, K (reprint author), Univ Michigan, Dept Mech Engn, 2350 Hayward Ave, Ann Arbor, MI 48109 USA. EM oldham@umich.edu NR 29 TC 21 Z9 21 U1 1 U2 8 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0960-1317 J9 J MICROMECH MICROENG JI J. Micromech. Microeng. PD JUL PY 2010 VL 20 IS 7 AR 075016 DI 10.1088/0960-1317/20/7/075016 PG 10 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 617DG UT WOS:000279260400016 ER PT J AU Birtle, AJ AF Birtle, Andrew James TI Advisory Service in Vietnam: Detrimental to an Officer's Career? SO JOURNAL OF MILITARY HISTORY LA English DT Article AB During the Vietnam War several beliefs gained currency that had negative implications for the men who labored as advisers. One was that the U.S. Army did not select its best men for advisory duty. Another was that promotion boards disregarded statements by senior Army leaders that command and advisory performance would be given the same weight when determining officer promotions. This article attempts to shed light on the question by examining the extent to which former Vietnam advisers achieved general officer rank in the U.S. Army. C1 USA, Ctr Mil Hist, Mil Operat Branch, Washington, DC USA. RP Birtle, AJ (reprint author), USA, Ctr Mil Hist, Mil Operat Branch, Washington, DC USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 871 EP 877 PG 7 WC History SC History GA 623NA UT WOS:000279746500007 ER PT J AU Fischer, JR AF Fischer, Joseph R. TI The US Army and Irregular Warfare: 1775-2007 SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Fischer, Joseph R.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Fischer, JR (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 917 EP 919 PG 3 WC History SC History GA 623NA UT WOS:000279746500017 ER PT J AU Connelly, DB AF Connelly, Donald B. TI Fields of Blood: The Prairie Grove Campaign SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Connelly, Donald B.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Connelly, DB (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 926 EP 927 PG 2 WC History SC History GA 623NA UT WOS:000279746500023 ER PT J AU Hull, MM AF Hull, Mark M. TI 1938: Hitler's Gamble SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Hull, Mark M.] USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Hull, MM (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 957 EP 958 PG 2 WC History SC History GA 623NA UT WOS:000279746500047 ER PT J AU House, JM AF House, Jonathan M. TI The Great Patriotic War of the Soviet Union, 1941-45: A Documentary Reader SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 960 EP 961 PG 2 WC History SC History GA 623NA UT WOS:000279746500049 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI D-Day: The Battle for Normandy SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bourque, Stephen A.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Bourque, SA (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 964 EP 965 PG 2 WC History SC History GA 623NA UT WOS:000279746500052 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI America's Cold War: The Politics of Insecurity SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. RP Rafuse, ES (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 977 EP 978 PG 2 WC History SC History GA 623NA UT WOS:000279746500061 ER PT J AU Schifferle, PJ AF Schifferle, Peter J. TI Not a Gentlemen's War: An Inside View of Junior Officers in the Vietnam War SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Schifferle, Peter J.] Sch Adv Mil Studies, Ft Leavenworth, KS USA. RP Schifferle, PJ (reprint author), Sch Adv Mil Studies, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 981 EP 983 PG 3 WC History SC History GA 623NA UT WOS:000279746500064 ER PT J AU Villard, EB AF Villard, Erik B. TI The Battle of Ngok Tavak: Allied Valor and Defeat in Vietnam SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Villard, Erik B.] USA, Ctr Mil Hist, Washington, DC USA. RP Villard, EB (reprint author), USA, Ctr Mil Hist, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2010 VL 74 IS 3 BP 984 EP 985 PG 2 WC History SC History GA 623NA UT WOS:000279746500066 ER PT J AU Heinlen, LD Ritterhouse, LL McClain, MT Keith, MP Neas, BR Harley, JB James, JA AF Heinlen, Latisha D. Ritterhouse, Lauren L. McClain, Micah T. Keith, Michael P. Neas, Barbara R. Harley, John B. James, Judith A. TI Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides SO JOURNAL OF MOLECULAR MEDICINE-JMM LA English DT Article DE Lupus; Antibodies; Autoimmunity; Ribosomal P; Epitope ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; PROTEIN ANTIBODIES; REVISED CRITERIA; ASSOCIATION; DIAGNOSIS; DISEASE; EPITOPE; CLASSIFICATION; AUTOIMMUNITY; EVENTS AB Autoantibodies to ribosomal P (ribo P) are found in 15-30% of systemic lupus erythematosus (SLE) patients and are highly specific for SLE. The goal of this study is to assess the temporal association of anti-ribosomal P (anti-P) responses with SLE disease onset, as well as to characterize select humoral ribo P epitopes targeted in early, pre-diagnostic SLE samples. Patients with stored serial serum samples available prior to SLE diagnosis were identified from a military cohort. Each sample was tested for antibodies against ribo P utilizing standard C terminus ribo P enzyme-linked immunosorbent assays (ELISA) and a solid phase, bead-based assay with affinity-purified ribo P proteins. In this study, antibodies to ribo P were more common in African American SLE patients (p = 0.026), and anti-P-positive patients comprised a group with more measured autoantibody specificities than did other SLE patients (3.5 vs 2.2, p < 0.05). Antibodies against ribo P were present on average 1.7 years before SLE diagnosis and were detected an average of 1.08 years earlier in pre-diagnostic SLE samples using affinity-purified whole protein rather than C-terminal peptide alone (p = 0.0019). Furthermore, 61% of anti-P-positive patients initially had antibodies to aa 99-113, a known ribosomal P0 antigenic target, at a time point when no antibodies to the clinically used C terminus were detected. Our findings provide evidence that antibodies against ribosomal P frequently develop before clinical SLE diagnosis and are more broadly reactive than previously thought by targeting regions outside of the C terminus. C1 [Heinlen, Latisha D.; Ritterhouse, Lauren L.; McClain, Micah T.; Harley, John B.; James, Judith A.] Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. [Heinlen, Latisha D.; Ritterhouse, Lauren L.; Neas, Barbara R.; Harley, John B.; James, Judith A.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA. [Keith, Michael P.] Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Keith, Michael P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Harley, John B.] US Dept Vet Affairs, Med Ctr, Oklahoma City, OK 73104 USA. RP James, JA (reprint author), Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA. EM Judith-James@omrf.org FU National Institutes of Health [AI82714, AI31584, AR58554, AR45451, AI47575, AR53483, AR48045, AR45084, AR45231, AR42460, AR48940, AI24717, RR20143, RR15577, RR14467]; Presbyterian Health Foundation; Lou Kerr Chair in Biomedical Research; Kirkland Foundation; US Department of Veteran Affairs FX The authors would like to thank Yasmin Akbarali MS, Roy Rindler MD, Tara Bruner PA-C, and Gabriel Vidal for their technical assistance and Scott Stewart MS for his statistical analysis assistance. This work has been supported by the National Institutes of Health (AI82714, AI31584, AR58554, AR45451, AI47575, AR53483, AR48045, AR45084, AR45231, AR42460, AR48940, AI24717, RR20143, RR15577, and RR14467), the Presbyterian Health Foundation, the Lou Kerr Chair in Biomedical Research, the Kirkland Foundation, and the US Department of Veteran Affairs. The opinions and assertions contained herein are private views of the authors and are not to be construed as official or as reflecting the views of the Army, Navy, or the Department of Defense. NR 32 TC 20 Z9 20 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0946-2716 J9 J MOL MED JI J. Mol. Med. PD JUL PY 2010 VL 88 IS 7 BP 719 EP 727 DI 10.1007/s00109-010-0618-1 PG 9 WC Genetics & Heredity; Medicine, Research & Experimental SC Genetics & Heredity; Research & Experimental Medicine GA 602DY UT WOS:000278119900009 PM 20396862 ER PT J AU Bowen, DK Mitchell, LA Burnett, MW Rooks, VJ Martin, JE AF Bowen, Donnell K. Mitchell, Lex A. Burnett, Mark W. Rooks, Veronica J. Martin, Jonathan E. TI Spinal epidural abscess due to tropical pyomyositis in immunocompetent adolescents Report of 2 cases SO JOURNAL OF NEUROSURGERY-PEDIATRICS LA English DT Article DE spinal epidural abscess; paraspinal abscess; pyomyositis ID MYOSITIS; CHILDREN AB Pyomyositis, a suppurative infection of skeletal muscle, is a disease not frequently encountered by neurosurgical providers. While previously considered an infection localized to tropical and semitropical locations, clinical reports of pyomyositis in temperate climates have increased over the past decade. Paraspinal involvement is uncommon in pyomyositis; however, the potential exists for spread into the epidural space resulting in a spinal epidural abscess (SEA). Early diagnosis of an SEA is frequently hampered by the absence of specific signs, unfamiliarity with the disease, atypical manifestations, and a broad differential diagnosis that includes more common causes of back pain. To date, 1 such case of paraspinal pyomyositis associated with an SEA has been reported in the neurosurgical literature. The authors present 2 cases of pyomyositis with an SEA and review the epidemiology, pathophysiology, diagnostic workup, and management of this disorder. (DOI: 10.3171/2010.3.PEDS1017) C1 [Martin, Jonathan E.] Univ Connecticut, Sch Med, Dept Surg, Connecticut Childrens Med Ctr,Div Neurosurg, Hartford, CT 06106 USA. [Bowen, Donnell K.; Martin, Jonathan E.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. [Mitchell, Lex A.; Rooks, Veronica J.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. [Burnett, Mark W.] Tripler Army Med Ctr, Dept Infect Dis, Honolulu, HI 96859 USA. [Rooks, Veronica J.] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. RP Martin, JE (reprint author), Univ Connecticut, Sch Med, Dept Surg, Connecticut Childrens Med Ctr,Div Neurosurg, 282 Washington St, Hartford, CT 06106 USA. EM jmartin03@ccmckids.org NR 17 TC 6 Z9 8 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1933-0707 J9 J NEUROSURG-PEDIATR JI J. Neurosurg.-Pediatr. PD JUL PY 2010 VL 6 IS 1 BP 33 EP 37 DI 10.3171/2010.3.PEDS1017 PG 5 WC Clinical Neurology; Pediatrics; Surgery SC Neurosciences & Neurology; Pediatrics; Surgery GA 615BV UT WOS:000279107100006 PM 20593985 ER PT J AU Scrimgeour, AG Marchitelli, LJ Whicker, JS Song, Y Ho, E Young, AJ AF Scrimgeour, Angus G. Marchitelli, Louis J. Whicker, Jered S. Song, Yang Ho, Emily Young, Andrew J. TI Phytase supplementation increases bone mineral density, lean body mass and voluntary physical activity in rats fed a low-zinc diet SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Zinc; Phytase; Bone mineral density; Exercise ID GROWING RATS; RISK-FACTORS; BIOMECHANICAL PROPERTIES; HIP FRACTURE; SERUM ZINC; DEFICIENCY; EXERCISE; MEN; STRENGTH; GROWTH AB Phytic acid forms insoluble complexes with nutritionally essential minerals, including zinc (Zn). Animal studies show that addition of microbial phytase (P) to low-Zn diets improves Zn status and bone strength. The present study determined the effects of phytase supplementation on bone mineral density (BMD), body composition and voluntary running activity of male rats fed a high phytic acid, low-Zn diet. In a factorial design, rats were assigned to ZnLO (5 mg/kg diet), ZnLO +P (ZnLO diet with 1500 U phytase/kg) or ZnAD (30 mg/kg diet) groups and were divided into voluntary exercise (EX) or sedentary (SED) groups, for 9 weeks. SED rats were significantly heavier from the second week, and no catch-up growth occurred in EX rats. Feed intakes were not different between groups throughout the study. ZnLO animals had decreased food efficiency ratios compared to both phytase-supplemented (ZnLO+P) and Zn-adequate (ZnAD) animals (P<01 compared to ZnLO). The ZnLO+P and ZnAD rats ran 56-75 km more total distance than ZnLO rats (P<05), with the ZnLO+P rats running more kilometers per week than the ZnLO rats by Week 6. In vivo DEXA analyses indicate that rats fed phytase-supplemented diets had higher lean body mass (LBM) than those fed ZnLO diets; and that rats fed the Zn-adequate diets had the highest LBM. Body fat (%) was significantly lower in EX rats and was both Zn- and phytase insensitive. Rats fed phytase-supplemented diets had higher bone mineral content (BMC), bone area (BA) and BMD than rats fed ZnLO diets; and in rats fed ZnAD diets these indices were the highest. The dietary effects on BMC, BA and BMD were independent of activity level. We conclude that consuming supplemental dietary phytase or dietary Zn additively enhances Zn status to increase BMD, LBM and voluntary physical activity in rats fed a low-Zn diet. While the findings confirm that bone health is vulnerable to disruption by moderate Zn deficiency in rats, this new data suggests that if dietary Zn is limiting, supplemental phytase may have beneficial effects on LBM and performance activity. Published by Elsevier Inc. C1 [Scrimgeour, Angus G.; Marchitelli, Louis J.; Whicker, Jered S.; Young, Andrew J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Song, Yang; Ho, Emily] Oregon State Univ, Linus Pauling Inst Sci & Med, Dept Nutr & Exercise Sci, Corvallis, OR 97331 USA. RP Scrimgeour, AG (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM angus.scrimgeour@us.army.mil RI Song, Yang/D-6331-2011; Scrimgeour, Angus/D-6794-2013 FU US Army MRMC FX This study was funded by the US Army MRMC. NR 43 TC 4 Z9 5 U1 1 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0955-2863 J9 J NUTR BIOCHEM JI J. Nutr. Biochem. PD JUL PY 2010 VL 21 IS 7 BP 653 EP 658 DI 10.1016/j.jnutbio.2009.03.015 PG 6 WC Biochemistry & Molecular Biology; Nutrition & Dietetics SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA 618NS UT WOS:000279363200012 PM 19576752 ER PT J AU Hebert, JJ Marcus, RL Koppenhaver, SL Fritz, JM AF Hebert, Jeffrey J. Marcus, Robin L. Koppenhaver, Shane L. Fritz, Julie M. TI Postoperative Rehabilitation Following Lumbar Discectomy With Quantification of Trunk Muscle Morphology and Function: A Case Report and Review of the Literature SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Review DE adipose; discectomy; exercise therapy; rehabilitation; skeletal muscle; ultrasonography ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; FEEDFORWARD POSTURAL RESPONSES; CROSS-SECTIONAL AREA; SPINAL-CORD-INJURY; MULTIFIDUS MUSCLE; DISC HERNIATION; TRANSVERSUS ABDOMINIS; PARASPINAL MUSCLES; EXERCISE PROGRAM AB STUDY DESIGN: A case report and literature review. BACKGROUND: Optimizing clinical outcomes following lumbar disc surgery is a research priority; however, relatively little attention has been paid to the postoperative management of this population. The transversus abdominis and lumbar multifidus (LM) muscles appear to play a unique role in lumbar spine stability, and may relate to clinical outcome following lumbar disc surgery. The purpose of this case report was to describe the preoperative LM morphology, clinical outcome, and change in transversus abdominis and LM muscle activation in a patient following lumbar disc surgery and motor control exercise initiated in the early postoperative period. CASE DESCRIPTION: A 29-year-old female underwent an 8-week postoperative rehabilitation program emphasizing motor control exercises to restore trunk muscle function 10 days following lumbar disc surgery. OUTCOMES: The patient experienced clinically important improvements in pain and disability following the postoperative rehabilitation program. Substantial improvements in muscle activation were observed of the transversus abdominis and the LM at the L4-5 level. Minimal change in LM activation and a higher proportion of intramuscular fat was observed at the L5-S1 level. DISCUSSION: This case report represents limited evidence regarding the feasibility of instituting a rehabilitation program in the early postoperative period following lumbar disc surgery. Improvements in clinical status and muscle function were observed, and a differential change in muscle activation between the L4-5 and L5-S1 levels was noted. The literature regarding rehabilitation following lumbar disc surgery, as well as the neuromuscular changes observed in this population, was reviewed. Additionally, a novel method of examining LM morphology was described and suggestions were made for directions of future research. LEVEL OF EVIDENCE: Therapy, level 4. J Orthop Sports Phys Ther 2010;40(7):402-412. doi:10.2519/jospt.2010.3332 C1 [Hebert, Jeffrey J.] Murdoch Univ, Sch Chiropract & Sports Sci, Fac Hlth Sci, Murdoch, WA 6150, Australia. [Marcus, Robin L.; Fritz, Julie M.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA. [Koppenhaver, Shane L.] Baylor Univ, USA, San Antonio, TX USA. [Fritz, Julie M.] Intermt Hlth Care, Salt Lake City, UT USA. RP Hebert, JJ (reprint author), Murdoch Univ, Sch Chiropract & Sports Sci, Fac Hlth Sci, Murdoch, WA 6150, Australia. EM j.hebert@Murdoch.edu.au RI Hebert, Jeffrey/C-4614-2008 OI Hebert, Jeffrey/0000-0002-6959-325X NR 120 TC 7 Z9 7 U1 1 U2 8 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUL PY 2010 VL 40 IS 7 BP 402 EP 412 DI 10.2519/jospt.2010.3332 PG 11 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 620PA UT WOS:000279510600003 PM 20592478 ER PT J AU Mitchell, B AF Mitchell, Benjamin TI Killing in War. SO JOURNAL OF POLITICS LA English DT Book Review C1 [Mitchell, Benjamin] US Mil Acad, West Point, NY 10996 USA. RP Mitchell, B (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0022-3816 J9 J POLIT JI J. Polit. PD JUL PY 2010 VL 72 IS 3 BP 914 EP 915 DI 10.1017/S0022381610000368 PG 2 WC Political Science SC Government & Law GA 630BG UT WOS:000280245500028 ER PT J AU Wolfenstine, J Allen, JL Read, J Sakamoto, J Gonalez-Doncel, G AF Wolfenstine, J. Allen, J. L. Read, J. Sakamoto, J. Gonalez-Doncel, G. TI Hot-pressed Li0.33La0.57TiO3 SO JOURNAL OF POWER SOURCES LA English DT Article DE Hot-pressing; Ionic conductivity; Microhardness; Sintering; Li-air ID LITHIUM LANTHANUM TITANATES; IONIC-CONDUCTIVITY; CERAMIC ELECTROLYTES; LI2O-AL2O3-TIO2-P2O5; SINTERABILITY; WATER AB The electrical and mechanical properties of hot-pressed versus sintered Li0.33La0.57TiO3 at temperature of 1050 degrees C were investigated. It was observed that hot-pressed Li0.33La0.57TiO3 exhibited a higher total Li-ion conductivity (similar to 20x) and hardness (similar to 11x) compared to sintered Li0.33La0.57TiO3 as a result of its higher density. Hot-pressed Li0.33La0.57TiO3 had a similar relative density and total Li-ion conductivity when compared to Li0.33La0.57TiO3 sintered at 1250 degrees C, where significant Li2O loss occurs. These results suggest that hot-pressing can be used as a consolidation method to reduce Li2O loss to obtain dense Li0.33La0.57TiO3. Published by Elsevier B.V. C1 [Wolfenstine, J.; Allen, J. L.; Read, J.] USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. [Sakamoto, J.] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA. [Gonalez-Doncel, G.] CSIC, CENIM, Dept Met Fis, E-28040 Madrid, Spain. RP Wolfenstine, J (reprint author), USA, Res Lab, AMSRD ARL SE DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jwolfenstine@arl.army.mil FU U.S. Army Research Laboratory (ARL) FX The authors would like to acknowledge support of the U.S. Army Research Laboratory (ARL). NR 31 TC 14 Z9 14 U1 5 U2 24 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUL 1 PY 2010 VL 195 IS 13 SI SI BP 4124 EP 4128 DI 10.1016/j.jpowsour.2009.12.109 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 584PL UT WOS:000276764600023 ER PT J AU Jabbour, RE Wade, MM Deshpande, SV Stanford, MF Wick, CH Zulich, AW Snyder, AP AF Jabbour, Rabih E. Wade, Mary Margaret Deshpande, Samir V. Stanford, Michael F. Wick, Charles H. Zulich, Alan W. Snyder, A. Peter TI Identification of Yersinia pestis and Escherichia coli Strains by Whole Cell and Outer Membrane Protein Extracts with Mass Spectrometry-Based Proteomics SO JOURNAL OF PROTEOME RESEARCH LA English DT Article DE Yersinia pestis; E. coli; Proteomics; Liquid chromatography; Electrospray; Tandem mass; spectrometry; Protein extract; Outer membrane proteins OMP; Whole cell proteins; Dendrogram; Bioinformatics ID RAPID IDENTIFICATION; BACILLUS-ANTHRACIS; DATABASE; BACTERIA; EXPRESSION; CLASSIFICATION; TRANSLOCATION; SECRETION; PATHOGENS; DIGESTION AB Whole cell protein and outer membrane protein (OMP) extracts were compared for their ability to differentiate and delineate the correct database organism to an experimental sample and for the degree of dissimilarity to the nearest neighbor database organism strains. These extracts were isolated from pathogenic and nonpathogenic strains of Yersinia pestis and Escherichia coli using ultracentrifugation and a sarkosyl extraction method followed by protein digestion and analysis using liquid chromatography tandem mass spectrometry (MS). Whole cell protein extracts contain many different types of proteins resident in an organism at a given phase in its growth cycle. OMPs, however, are often associated with virulence in Gram-negative pathogens and could prove to be model biomarkers for strain differentiation among bacteria. The mass spectra of bacterial peptides were searched, using the SEQUEST algorithm, against a constructed proteome database of microorganisms in order to determine the identity and number of unique peptides for each bacterial sample. Data analysis was performed with the in-house BACid software. It calculated the probabilities that a peptide sequence assignment to a product ion mass spectrum was correct and used accepted spectrum-to-sequence matches to generate a sequence-to-bacterium (STB) binary matrix of assignments. Validated peptide sequences, either present or absent in various strains (STB matrices), were visualized as assignment bitmaps and analyzed by the BACid module that used phylogenetic relationships among bacterial species as part of a decision tree process. The bacterial classification and identification algorithm used assignments of organisms to taxonomic groups (phylogenetic classification) based on an organized scheme that begins at the phylum level and follows through the class, order, family, genus, and species to the strain level. For both Gram-negative organisms, the number of unique distinguishing proteins arrived at by the whole cell method was less than that of the OMP method. However, the degree of differentiation measured in linkage distance units on a dendrogram with the OMP extract showed similar or significantly better separation than the whole cell protein extract method between the sample and correct database match compared to the next nearest neighbor. The nonpathogenic Y. pestis A1122 strain used does not have its genome available, and thus, data analysis resulted in an equal similarity index to the nonpathogenic 91001 and pathogenic Antigua and Nepal 516 strains for both extraction methods. Pathogenic and nonpathogenic strains of E. coli were correctly identified with both protein extraction methods, and the pathogenic Y. pestis CO92 strain was correctly identified with the OMP procedure. Overall, proteomic MS proved useful in the analysis of unique protein assignments for strain differentiation of E. coli and Y. pestis. The power of bacterial protein capture by the whole cell protein and OMP extraction methods was highlighted by the data analysis techniques and revealed differentiation and similarities between the two protein extraction approaches for bacterial delineation capability. C1 [Jabbour, Rabih E.] USA, Edgewood Area, Sci Applicat Int Corp, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Deshpande, Samir V.] Sci & Technol Corp, Edgewood, MD 21040 USA. RP Jabbour, RE (reprint author), USA, Edgewood Area, Sci Applicat Int Corp, Edgewood Chem Biol Ctr, Bldg E3160, Aberdeen Proving Ground, MD 21010 USA. EM rabih.jabbour@us.army.mil FU U.S. Army Edgewood Chemical Biological Center's In-house Laboratory FX This work was funded by the 2009 U.S. Army Edgewood Chemical Biological Center's In-house Laboratory Independent Research program. NR 52 TC 21 Z9 21 U1 0 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1535-3893 J9 J PROTEOME RES JI J. Proteome Res. PD JUL PY 2010 VL 9 IS 7 BP 3647 EP 3655 DI 10.1021/pr100402y PG 9 WC Biochemical Research Methods SC Biochemistry & Molecular Biology GA 618BY UT WOS:000279327500026 PM 20486690 ER PT J AU Lawless, HT Cardello, AV Chapman, KW Lesher, LL Given, Z Schutz, HG AF Lawless, Harry T. Cardello, Armand V. Chapman, Kathryn W. Lesher, Larry L. Given, Zachary Schutz, Howard G. TI A COMPARISON OF THE EFFECTIVENESS OF HEDONIC SCALES AND END-ANCHOR COMPRESSION EFFECTS SO JOURNAL OF SENSORY STUDIES LA English DT Article ID ACROSS-GROUP COMPARISONS; LONG-TERM ACCEPTABILITY; MAGNITUDE SCALE; LABELED SCALES; TASTE; PERFORMANCE; SWEETNESS; CATEGORY; HYBRID AB Three experiments were conducted to compare the relative performance of hedonic scaling methods, including the labeled affective magnitude (LAM) scale. In the first study, three versions of the LAM were used to evaluate 20 phrases that described diverse sensory experiences. One scale was anchored to "greatest imaginable like/dislike for any experience" and another used the "greatest imaginable like" phrase of the LAM but with the interior phrases repositioned relative to "any experience." The scale anchored to "any experience" showed a smaller range of scale usage and lower statistical differentiation, relative to the LAM scale, with the repositioned scale intermediate. Two further experiments compared the LAM to the nine-point hedonic scale, an 11-point category scale using the LAM phrases, and to a three-label line scale, a simplified version of the LAM with only the end phrases and the neutral center-point phrase. All scales showed similar differentiation of juices in the second study and sensory experience phrases in the third. A modest advantage for the LAM scale in the second experiment did not extend to the third study. Researchers should be careful in the choice of high end anchors for hedonic scales, as a compressed range of scale usage may result in lower product differentiation. PRACTICAL APPLICATIONS Hedonic scales for food acceptability are widely used in new product development for consumer testing and in food preference surveys. A desired goal of efficient sensory evaluation testing is the ability of tests to differentiate samples on the basis of scale data, in this case scales commonly used for food acceptability and preference testing. Scales which are able to differentiate products more effectively are less likely to lead to Type II error in experimentation, in which true differences between products are not detected. Such errors can lead to lost opportunities for product improvements or to enhanced chances for taking undetected risks in the case of false parity conclusions. C1 [Lawless, Harry T.; Chapman, Kathryn W.] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA. [Cardello, Armand V.; Lesher, Larry L.; Given, Zachary] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Schutz, Howard G.] Univ Calif Davis, Davis, CA 95616 USA. RP Lawless, HT (reprint author), Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA. EM htl1@cornell.edu NR 25 TC 5 Z9 5 U1 1 U2 11 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0887-8250 J9 J SENS STUD JI J. Sens. Stud. PD JUL PY 2010 VL 25 SU 1 BP 18 EP 34 DI 10.1111/j.1745-459X.2009.00270.x PG 17 WC Food Science & Technology SC Food Science & Technology GA 626SN UT WOS:000279987300002 ER PT J AU Chapman, KW Lovelace, E Cardello, A Lawless, HT AF Chapman, Kathryn W. Lovelace, Eugene Cardello, Armand Lawless, Harry T. TI PREFERENCE FOR ONE OF TWO IDENTICAL STIMULI: EXPECTATIONS, EXPLICIT INSTRUCTIONS AND PERSONAL TRAITS SO JOURNAL OF SENSORY STUDIES LA English DT Article ID ABSOLUTE JUDGMENT; FREQUENCY; CHOICE; OPTIONS; SCALE; TESTS; MODEL AB Most consumers, given two identical food samples, express a preference for one, rather than choosing a no-preference option. The stability and potential causes of this seemingly irrational preference were examined across three trials under different conditions, specifically, when the first test pair was identical or different, and when participants were explicitly told that the pairs would often be identical. Choice of no preference typically increased from the first to second trial, especially for groups who saw a pair of different samples on the first trial. The explicit instruction that samples might be the same failed to reduce expressing a preference on the initial trial although it had some effect on later trials. Analysis, by individuals, of sequences of preference or no-preference responses across trials support independence of sequential responses and argue against stable personal traits as a predictor of preference choice. PRACTICAL APPLICATIONS More research needs to be done to understand the origins and operation of biases in preference tests. When tested under conditions in which the samples differ only slightly, participants tend to avoid the no-preference option. This is potentially important when interpreting the results of preference tests and assigning practical significance to their outcomes. Also, single trial testing may produce somewhat different results from multi-trial testing, the latter allowing for examination of effects of variation in recent experience. C1 [Chapman, Kathryn W.; Lawless, Harry T.] Cornell Univ, Dept Food Sci, Ithaca, NY 14850 USA. [Lovelace, Eugene] Alfred Univ, Dept Psychol, Alfred, NY 14802 USA. [Cardello, Armand] USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Chapman, KW (reprint author), Cornell Univ, Dept Food Sci, Ithaca, NY 14850 USA. EM kwc3@cornell.edu NR 28 TC 8 Z9 8 U1 2 U2 5 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0887-8250 J9 J SENS STUD JI J. Sens. Stud. PD JUL PY 2010 VL 25 SU 1 BP 35 EP 53 DI 10.1111/j.1745-459X.2010.00294.x PG 19 WC Food Science & Technology SC Food Science & Technology GA 626SN UT WOS:000279987300003 ER PT J AU Stone, AG Riedel, MS Dahl, T Selegean, J AF Stone, Amanda G. Riedel, Mark S. Dahl, Travis Selegean, James TI Application and validation of a GIS-based stream bank stability tool for the Great Lakes region SO JOURNAL OF SOIL AND WATER CONSERVATION LA English DT Editorial Material ID RIVER CHANNEL PATTERNS; VEGETATION; STRENGTH C1 [Stone, Amanda G.; Riedel, Mark S.] WF Baird & Associates Ltd, Madison, WI USA. [Dahl, Travis; Selegean, James] Detroit Dist US Army Corps Engineers, Detroit, MI USA. RP Stone, AG (reprint author), WF Baird & Associates Ltd, Madison, WI USA. RI Dahl, Travis/I-8591-2012 OI Dahl, Travis/0000-0003-2422-3965 NR 35 TC 0 Z9 0 U1 1 U2 3 PU SOIL WATER CONSERVATION SOC PI ANKENY PA 945 SW ANKENY RD, ANKENY, IA 50023-9723 USA SN 0022-4561 J9 J SOIL WATER CONSERV JI J. Soil Water Conserv. PD JUL-AUG PY 2010 VL 65 IS 4 BP 92A EP 98A DI 10.2489/jswc.65.4.92A PG 7 WC Ecology; Soil Science; Water Resources SC Environmental Sciences & Ecology; Agriculture; Water Resources GA 629WZ UT WOS:000280232700004 ER PT J AU Merullo, DJ Goldman, SB Antczak, AJ Banderet, LE Fairbrother, JT AF Merullo, Donna J. Goldman, Sarah B. Antczak, Amanda J. Banderet, Louis E. Fairbrother, Jeffrey T. TI A simple weighting procedure eliminates distance effects on radial error for rifle marksmanship SO JOURNAL OF SPORT & EXERCISE PSYCHOLOGY LA English DT Meeting Abstract C1 [Merullo, Donna J.; Goldman, Sarah B.; Antczak, Amanda J.; Banderet, Louis E.] USA, Environm Med Res Inst, Washington, DC USA. [Fairbrother, Jeffrey T.] Univ Tennessee, Knoxville, TN USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 0895-2779 J9 J SPORT EXERCISE PSY JI J. Sport Exerc. Psychol. PD JUL PY 2010 VL 32 SU S BP S110 EP S111 PG 2 WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology; Sport Sciences SC Social Sciences - Other Topics; Psychology; Sport Sciences GA 616VM UT WOS:000279238600198 ER PT J AU Riojas, CM Hahn, CD Johnson, EK AF Riojas, Christina M. Hahn, Christina D. Johnson, Eric K. TI Presacral Epidermoid Cyst in a Male: A Case Report and Literature Review SO JOURNAL OF SURGICAL EDUCATION LA English DT Review DE presacral cysts; epidermoid cysts; developmental cysts; transabdominal excision of presacral cyst; incidental presacral masses ID CURRARINO TRIAD; RETRORECTAL TUMORS; ADULT AB Presacral cysts are an uncommon entity most often found incidentally in women. These tumors can arise from any of the 1 or more cell lines present in the presacral space during embryogenesis. We present a case of a 46-year-old male patient who was found to have a well-circumscribed presacral mass on computed tomography (CT) scan, which was obtained for his complaint of vague lower back pain. He underwent transabdominal excision, and pathology revealed a presacral epidermoid cyst filled with keratinaceous material. Presacral cysts are rare, especially in male patients. These tumors originate from an embryologic error during development. Because of the risk of infection and malignant transformation, they should be excised. Surgical options include a posterior approach, transabdominal approach, combined approach, or transrectal approach. The approach is dictated by the tumor size, location, presence of malignancy, and bony invasion. (J Surg 67:227-232. (C) 2010 Association of Program Directors in Surgery,. Published by Elsevier Inc. All rights reserved.) C1 [Riojas, Christina M.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA USA. [Johnson, Eric K.] Dwight D Eisenhower Army Med Ctr, Dept Colon & Rectal Surg, Ft Gordon, GA USA. [Hahn, Christina D.] Landstuhl Reg Med Ctr, Rheinland Pfalz, Germany. RP Johnson, EK (reprint author), Eisenhower Army Med Ctr, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM eric.k.johnson@us.army.mil NR 19 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1931-7204 J9 J SURG EDUC JI J. Surg. Educ. PD JUL-AUG PY 2010 VL 67 IS 4 BP 227 EP 232 DI 10.1016/j.jsurg.2010.06.005 PG 6 WC Education, Scientific Disciplines; Surgery SC Education & Educational Research; Surgery GA 651KI UT WOS:000281926200007 PM 20816358 ER PT J AU Falls, J Datta, A Chopra, I AF Falls, Jaye Datta, Anubhav Chopra, Inderjit TI Integrated Trailing-Edge Flaps and Servotabs for Helicopter Primary Control SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID ROTOR; VALIDATION AB A swashplateless rotor has the potential to reduce the aircraft empty weight, rotor drag, and control power requirement in forward flight, in addition to providing individual blade control capability for vibration reduction and noise mitigation. The focus of the present paper is on primary control using a servotab actuated trailing edge flap system to control blade pitch. First, concept feasibility is established through wind tunnel testing of a nonrotating wing section. Next, a rigid blade aeroelastic trim analysis is carried out in forward flight for a Kaman-type conceptual rotor with very low blade torsional stiffness. A parametric sensitivity study determined an optimized design space that simultaneously reduces tab deflections and hinge moments. Finally, the flap and tab dynamics are modeled within a comprehensive analysis that includes the inertial and aerodynamic contributions of the flap and the tab, blade flexibility, a two-dimensional unsteady aerodynamic model, and free wake. A UH-60A type helicopter at 155 kt (mu = 0.368) and 17,500-lb thrust (c(r)/sigma = 0.084), and tab-actuated trailing edge flaps with 22% flap chord and 13% tab chord, is trimmed using tab deflections within +/- 5 degrees, and mean tab hinge moment less than 3 ft-lb. C1 [Falls, Jaye; Chopra, Inderjit] Univ Maryland, Dept Aerosp Engn, Alfred Gessow Rotorcraft Ctr, College Pk, MD 20742 USA. [Datta, Anubhav] NASA, Ames Res Ctr, ELORET Corp, US Army Aeroflightdynam Directorate, Moffett Field, CA 94035 USA. RP Falls, J (reprint author), Univ Maryland, Dept Aerosp Engn, Alfred Gessow Rotorcraft Ctr, College Pk, MD 20742 USA. EM jaye@umd.edu NR 15 TC 5 Z9 5 U1 0 U2 2 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2010 VL 55 IS 3 AR 032005 DI 10.4050/JAHS.55.032005 PG 15 WC Engineering, Aerospace SC Engineering GA 745TI UT WOS:000289189000005 ER PT J AU Malovrh, B Gandhi, F AF Malovrh, Brendon Gandhi, Farhan TI Localized Individual Blade Root Pitch Control for Helicopter Blade-Vortex Interaction Noise Reduction SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID HIGHER HARMONIC CONTROL; ROTOR AB A numerical study was conducted on a four-bladed model rotor to investigate the potential of individual blade root pitch control (IBC) in reducing blade- vortex interaction (BVI) noise. Localized IBC inputs in the second quadrant were considered for weakening the advancing side interacting vortices, and similar inputs in the third quadrant were considered for weakening the retreating side interacting vortices. Second-quadrant IBC inputs were highly effective in reducing advancing side BVI noise, with 2 degrees and 3 degrees amplitude inputs practically eliminating advancing side BVI. noise. Third-quadrant IBC inputs had a limited effect on reducing retreating side BVI noise due to the higher baseline interacting vortex strengths on the retreating side and detrimental changes in interaction geometry. A combination of 3 degrees amplitude second- and third-quadrant IBC inputs were most effective, resulting in the practical elimination of advancing side BVI noise and a 4.6-dB overall reduction in peak BVI noise. C1 [Gandhi, Farhan] Penn State Univ, University Pk, PA 16802 USA. [Malovrh, Brendon] US Army Aeroflightdynam Directorate, Hampton, VA USA. RP Gandhi, F (reprint author), Penn State Univ, University Pk, PA 16802 USA. EM fgandhi@engr.psu.edu NR 23 TC 0 Z9 0 U1 2 U2 9 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2010 VL 55 IS 3 AR 032007 DI 10.4050/JAHS.55.032007 PG 12 WC Engineering, Aerospace SC Engineering GA 745TI UT WOS:000289189000007 ER PT J AU Raz, R Rosen, A Carmeli, A Lusardi, J Cicolani, LS AF Raz, Reuben Rosen, Aviv Carmeli, Avi Lusardi, Jeffery Cicolani, Luigi S. TI Wind Tunnel and Flight Evaluation of Passive Stabilization of a Cargo Container Slung Load SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article ID SLING-LOAD; HELICOPTER AB In forward flight helicopters carrying slung loads frequently encounter load instability problems that reduce their speed envelope to well below the power limit of the helicopter/slung-load system. The paper presents a procedure for the development and flight test verification of passive stabilizers designed to increase the maximum flight speed of the system. Most of the development is carried out during wind tunnel tests. A scale model is suspended from the tunnel ceiling by a gimbaled setup that simulates the hook-sling attachment. The model is free to perform lateral and longitudinal pendulum motions, as well as yaw rotation. All three motions are recorded as functions of time. The model dynamics are studied as a function of the wind tunnel speed. Various techniques for stabilizing the load can be investigated by wind tunnel tests, which are much cheaper, faster, and less risky than equivalent flight tests. The present study investigates the use of passive vertical fins to stabilize the 6 x 6 x 8 ft CONEX cargo container. The optimal geometry and location of the fins are determined in wind tunnel tests. Later on this optimal configuration is built and tested in full-scale flight tests. The dynamic behavior during these flight tests is compared with the wind tunnel results. Good agreement between both can result in a significant reduction in the number and duration of the flight tests that are required to certify the stabilization method. By using the above-described technique, the maximum flight speed of a UH-60/CONEX system is increased from 60 kt (the operational limit for the unstabilized CONEX) to 110 kt (the power limit of the system). C1 [Rosen, Aviv] Technion Israel Inst Technol, Haifa, Israel. NASA, Ames Res Ctr, Aerollightdynam Directorate AMRDEC, US Army Res Dev & Engn Command, Moffett Field, CA 94035 USA. San Jose State Univ Fdn, San Jose, CA USA. RP Rosen, A (reprint author), Technion Israel Inst Technol, Haifa, Israel. EM rosen@aerodyne.technion.ac.il FU wind tunnel team of the Faculty of Aerospace Engineering at the Technion FX The authors would like to thank Mr. A. Beer and the wind tunnel team of the Faculty of Aerospace Engineering at the Technion for their support during the wind tunnel tests. Thanks are also due to the mechanical design group of the Land Systems Unit of the Technion Research and Development Foundation, for the design of the full-scale fins. The authors would also like to thank the L3 Vertex Aerospace and the Science Application International personnel at Ames for the fabrication and installation of the stabilizers on the test load. NR 34 TC 10 Z9 11 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2010 VL 55 IS 3 AR 032001 DI 10.4050/JAHS.55.032001 PG 18 WC Engineering, Aerospace SC Engineering GA 745TI UT WOS:000289189000001 ER PT J AU Neigh, JJ AF Neigh, Jeffrey J. TI Developing future pharmacy leaders Pharmacy leaders should strive to possess five critical skills to be effective leaders in the profession SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION LA English DT Editorial Material C1 Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP Neigh, JJ (reprint author), Eisenhower Army Med Ctr, Ft Gordon, GA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER PHARMACEUTICAL ASSOC PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 USA SN 1544-3191 J9 J AM PHARM ASSOC JI J. Am. Pharm. Assoc. PD JUL-AUG PY 2010 VL 50 IS 4 BP 468 EP 470 DI 10.1331/JAPhA.2010.10524 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 632BS UT WOS:000280395700008 PM 20621861 ER PT J AU McMullin, NR Wade, CE Holcomb, JB Nielsen, TG Rossaint, R Riou, B Rizoli, SB Kluger, Y Choong, PIT Warren, B Tortella, BJ Boffard, KD AF McMullin, Neil R. Wade, Charles E. Holcomb, John B. Nielsen, Tina G. Rossaint, Rolf Riou, Bruno Rizoli, Sandro B. Kluger, Yoram Choong, Philip I. T. Warren, Brian Tortella, Bartholomew J. Boffard, Kenneth D. CA NovoSeven Trauma Study Grp TI Prolonged Prothrombin Time After Recombinant Activated Factor VII Therapy in Critically Bleeding Trauma Patients Is Associated With Adverse Outcomes SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Trauma; Prothrombin time; Recombinant activated factor VII; rFVIIa ID FRESH-FROZEN PLASMA; RECEIVING MASSIVE TRANSFUSIONS; LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; CLINICAL-TRIALS; BLOOD-PRODUCTS; MAJOR TRAUMA; RED-CELLS; SURVIVAL; MORTALITY AB Background: In trauma patients with significant hemorrhage, it is hypothesized that failure to normalize prothrombin time (PT) after recombinant activated factor VII (rFVIIa) treatment predicts poor clinical outcomes and potentially indicates a need for additional therapeutic interventions. Methods: To assess the value of PT to predict outcomes after rFVIIa or placebo therapy, we performed a post hoc analysis of data from 169 severely injured, critically bleeding trauma patients who had 1-hour postdose PT measurements from two randomized clinical trials. Baseline characteristics and outcome parameters were compared between subjects with 1-hour postdose PT >= 18 seconds and PT <18 seconds. Results: In rFVIIa-treated subjects, prolonged postdose PT values >= 18 seconds were associated with significantly higher 24-hour mortality (60% vs. 3%; p < 0.001) and 30-day mortality, increased incidence of massive transfusion, and fewer intensive care unit-free days compared with postdose PT values < 18 seconds. Recombinant rFVIIa-treated subjects with postdose PT >= 18 seconds had significantly lower baseline hemoglobin levels, fibrinogen levels, and platelet counts than subjects with postdose PT values >= 18 seconds even though they received similar amounts of blood products before rFVIIa dosing. Placebo-treated subjects with postdose PT >= 18 seconds had significantly increased incidence of massive transfusion, significantly decreased intensive care unit-free days, and significantly lower levels of fibrinogen and platelets at baseline compared with subjects with postdose PT values <18 seconds. Conclusions: The presence of prolonged PT after rFVIIa or placebo therapy was associated with poor clinical outcomes. Because subjects with postdosing PT >= 18 seconds had low levels of hemoglobin, fibrinogen, and platelets, this group may benefit from additional blood component therapy. C1 [McMullin, Neil R.] USA, Inst Surg Res, BAMC Ft Sam Houston, San Antonio, TX USA. [Wade, Charles E.; Holcomb, John B.] Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX 77030 USA. [Nielsen, Tina G.; Tortella, Bartholomew J.] Novo Nordisk AS, Novo Seven Key Projects, Med & Sci, DK-2880 Bagsvaerd, Denmark. [Rossaint, Rolf] Rhein Westfal TH Aachen, Univ Hosp Aachen, Dept Anesthesiol, Aachen, Germany. [Riou, Bruno] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Dept Emergency Med, Paris, France. [Riou, Bruno] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Dept Surg, Paris, France. [Riou, Bruno] Univ Paris 06, Hop La Pitie Salpetriere, AP HP, Dept Anesthesiol & Crit Care, Paris, France. [Rizoli, Sandro B.] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Surg & Crit Care Med, Toronto, ON, Canada. [Kluger, Yoram] Rambam Med Ctr, Dept Surg B, Haifa, Israel. [Choong, Philip I. T.] Natl Univ Singapore Hosp, Dept Surg, Singapore, Singapore. [Warren, Brian] Univ Stellenbosch, Dept Surg, ZA-7505 Tygerberg, South Africa. [Boffard, Kenneth D.] Univ Witwatersrand, Johannesburg Hosp, Dept Surg, Johannesburg, South Africa. RP Holcomb, JB (reprint author), Univ Texas Hlth Sci Ctr, Ctr Translat Injury Res, 6410 Fannin,Suite 1100, Houston, TX 77030 USA. EM john.holcomb@uth.tmc.edu RI Iau, Philip/B-4641-2011; OI Boffard, Kenneth/0000-0002-7159-5414 FU Novo Nordisk A/S FX Supported by Novo Nordisk A/S. NR 39 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 IS 1 BP 60 EP 69 DI 10.1097/TA.0b013e3181e17260 PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AQ UT WOS:000280010600009 PM 20622579 ER PT J AU Allen, PB Salyer, SW Dubick, MA Holcomb, JB Blackbourne, LH AF Allen, Paul B. Salyer, Steven W. Dubick, Michael A. Holcomb, John B. Blackbourne, Lorne H. TI Preventing Hypothermia: Comparison of Current Devices Used by the US Army in an In Vitro Warmed Fluid Model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Passive heating; Active heating; Blankets; In vitro model ID COMBAT CASUALTY CARE; TRAUMA; MORTALITY; IMPACT; TEMPERATURE; TRANSFUSION; EXPERIENCE; INJURY AB Background: The purpose of this study was to develop an in vitro torso model constructed with fluid bags and to determine whether this model could be used to differentiate between the heat prevention performance of devices with active chemical or radiant forced-air heating systems compared with passive heat loss prevention devices. Methods: We tested three active (Hypothermia Prevention Management Kit [HPMK], Ready-Heat, and Bair Hugger) and five passive (wool, space blankets, Blizzard blankets, human remains pouch, and Hot Pocket) hypothermia prevention products. Active warming devices included products with chemically or electrically heated systems. Both groups were tested on a fluid model warmed to 37 degrees C versus a control with no warming device. Core temperatures were recorded every 5 minutes for 120 minutes in total. Results: Products that prevent heat loss with an actively heated element performed better than most passive prevention methods. The original HPMK achieved and maintained significantly higher temperatures than all other methods and the controls at 120 minutes (p < 0.05). None of the devices with an actively heated element achieved the sustained 44 degrees C that could damage human tissue if left in place for 6 hours. The best passive methods of heat loss prevention were the Hot Pocket and Blizzard blanket, which performed the same as two of the three active heating methods tested at 120 minutes. Conclusions: Our in vitro fluid bag "torso" model seemed sensitive to detect heat loss in the evaluation of several active or passive warming devices. All active and most passive devices were better than wool blankets. Under conditions near room temperature, passive warming methods (Blizzard blanket or the Hot Pocket) were as effective as active warming devices other than the original HPMK. Further studies are necessary to determine how these data can translate to field conditions in preventing heat loss in combat casualties. C1 [Allen, Paul B.; Salyer, Steven W.; Dubick, Michael A.; Holcomb, John B.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Dubick, MA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Michael.dubick@amedd.army.mil FU Kelly Thompson; Dominique Greydanus FX We thank Briza Horace for assistance in the preparation of this article and John Jones for assistance in the statistical analysis. In addition, we thank Kelly Thompson and Dominique Greydanus for their support in helping us accomplish this study. NR 23 TC 12 Z9 15 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S154 EP S161 DI 10.1097/TA.0b013e3181e45ba5 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000023 PM 20622611 ER PT J AU Beekley, AC Martin, MJ Nelson, T Grathwohl, KW Griffith, M Beilman, G Holcomb, JB AF Beekley, Alec C. Martin, Matthew J. Nelson, Teresa Grathwohl, Kurt W. Griffith, Matthew Beilman, Gregory Holcomb, John B. TI Continuous Noninvasive Tissue Oximetry in the Early Evaluation of the Combat Casualty: A Prospective Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Near-infrared spectroscopy; Tissue oxygenation saturation; Shock; Transfusion; Life-saving interventions ID NEAR-INFRARED SPECTROSCOPY; OXYGEN-SATURATION PREDICTS; TRAUMA PATIENTS; MASSIVE TRANSFUSION; LIFESAVING INTERVENTIONS; SPLANCHNIC PERFUSION; FLUID RESUSCITATION; EARLY COAGULOPATHY; HEMORRHAGIC-SHOCK; MORTALITY AB Background: We hypothesized that near-infrared spectroscopy (NIRS)-derived tissue oxygenation saturation (StO(2)) could assist in identifying shock in casualties arriving to a combat support hospital and predict the need for life-saving interventions (LSIs) and blood transfusions. Methods: We performed a prospective observational trial at a single US Army combat support hospital in Iraq from August to December 2007. Arriving casualties had NIRS-derived StO(2) recorded in the emergency department. Minimum (StO(2) min) and initial 2-minute averaged StO(2) and tissue hemoglobin index readings were used as end points. Outcomes measured were requirement for LSIs, any blood transfusion, massive transfusion (>10 units in 24 hours), and early mortality. The data were subjected to univariate and multivariate logistic regression modeling. Results: Of the 147 combat casualties enrolled in the trial, 72 (49%) required an LSI, 42 (29%) required blood transfusion, and 10 (7%) required massive transfusion. On multivariate logistic regression analysis of the whole study group, systolic blood pressure (SBP), international normalized ratio, tissue hemoglobin index, and hematocrit predicted blood transfusion with an area under the curve of 0.90 (0.84-0.96), with a confidence interval of 95%. When just the group with an SBP >90 was analyzed, independent predictors of patients requiring blood transfusion on logistic regression analysis were StO(2) min (odds ratio of 1.35) and hematocrit (odds ratio of 2.66) for an area under the curve of 0.84 (0.76-0.92). Conclusions: NIRS-derived StO(2) obtained on arrival predicts the need for blood transfusion in casualties who initially seem to be hemodynamically stable (SBP >90). Further study of this technology for use in the resuscitation of trauma patients is warranted. C1 [Beekley, Alec C.; Martin, Matthew J.] Madigan Army Med Ctr, Dept Gen Surg, Tacoma, WA 98431 USA. [Nelson, Teresa] Techn Res LLC, Minneapolis, MN USA. [Grathwohl, Kurt W.] Brooke Army Med Ctr, Dept Anesthesiol Crit Care Med, San Antonio, TX USA. [Griffith, Matthew] Brooke Army Med Ctr, Dept Infect Dis, San Antonio, TX USA. [Beilman, Gregory] Univ Minnesota, Dept Surg Crit Care, Minneapolis, MN USA. [Holcomb, John B.] Univ Texas Houston, Hlth Sci Ctr, Div Acute Care Surg, Houston, TX USA. RP Beekley, AC (reprint author), Madigan Army Med Ctr, Dept Gen Surg, 9040-A Fitzsimmons Rd, Ft Lewis, WA 98431 USA. EM alec.beekley@amedd.army.mil RI Martin, Matthew/B-2676-2014; OI Martin, Matthew/0000-0002-9169-9069; Beilman, Gregory/0000-0001-5036-3027 FU Hutchinson Technology, Inc. FX We thank Hutchinson Technology, Inc., for providing The InSpectra (TM) StO2 Tissue Oxygenation Monitors (InSpectra 650 (TM), Hutchinson Technology, Inc.) and disposable sensors on loan to perform this research in Baghdad, Iraq. We also thank members of the second and third Deployed Combat Casualty Care Research Teams for their hard work in collecting the data. Statistical support was provided by Technomics Research, LLC (Teresa Nelson), and statistics were also independently verified by the first and second authors. NR 28 TC 33 Z9 33 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S14 EP S25 DI 10.1097/TA.0b013e3181e42326 PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000004 PM 20622608 ER PT J AU Blackbourne, LH Czarnik, J Mabry, R Eastridge, B Baer, D Butler, F Pruitt, B AF Blackbourne, Lorne H. Czarnik, James Mabry, Robert Eastridge, Brian Baer, David Butler, Frank Pruitt, Basil, Jr. TI Decreasing Killed in Action and Died of Wounds Rates in Combat Wounded SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material ID TRANSFUSED TRAUMA PATIENTS; MASSIVE TRANSFUSION; DAMAGE CONTROL; DILUTIONAL COAGULOPATHY; BLOOD-PRODUCTS; PLASMA; DEATH; CARE; RESUSCITATION; CASUALTIES C1 [Blackbourne, Lorne H.; Eastridge, Brian; Baer, David] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Czarnik, James] USA, Special Operat Command, Ft Bragg, NC USA. [Mabry, Robert] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. [Butler, Frank] Comm Tact Combat Casualty Care, Tampa, FL USA. [Pruitt, Basil, Jr.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, San Antonio, TX 78284 USA. RP Blackbourne, LH (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers, Ft Sam Houston, TX 78234 USA. EM lorne.h.blackbourne@us.army.mil NR 46 TC 33 Z9 33 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S1 EP S4 DI 10.1097/TA.0b013e3181e4206f PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000001 PM 20622601 ER PT J AU Brown, KV Dharm-Datta, S Potter, BK Etherington, J Mistlin, A Hsu, JR Clasper, JC AF Brown, Kate V. Dharm-Datta, Shresth Potter, B. Kyle Etherington, John Mistlin, Alan Hsu, Joseph R. Clasper, Jon C. TI Comparison of Development of Heterotopic Ossification in Injured US and UK Armed Services Personnel With Combat-Related Amputations: Preliminary Findings and Hypotheses Regarding Causality SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Heterotopic ossification; Risk factors; Amputation level; Blast; Patient exposure ID TRAUMATIC BRAIN-INJURY; STAPHYLOCOCCUS-AUREUS; HUMAN OSTEOBLASTS; BONE-FORMATION; RISK-FACTORS; EXPRESSION; EXPERIENCE; MANAGEMENT; SEVERITY; MOUSE AB Background: Recent reports have documented the rate of heterotopic ossification (HO) formation in the residual limbs of combat-related amputees from the US Armed Forces injured in Operations Iraqi and Enduring Freedom. Final amputation level within the zone of injury and blast as the mechanism of injury were identified as possible risk factors for the occurrence and grade of HO. There has been no previous description of HO in combat-related amputees from the UK service personnel. The purpose of this study was to examine potential differences in the prevalence of HO between UK and US Allied Forces, with particular attention to these risk factors, patient exposures, and any treatment differences between these two groups. Methods: We reviewed the medical records and radiographs of 35 combat-related amputations from the UK and contrasted them with 213 previously reported amputations in US military personnel. We evaluated prevalence and severity of residual limb HO, Injury Severity Score (ISS), the mechanism and zone of injury, type and level of amputation, number of debridements, method of wound irrigation, presence of severe head injury and/or burns injury, use of topical negative pressure therapy and pulse lavage, number of days until wound closure, type of closure, and subsequent infections. All patients had a minimum of 2-month posthospital discharge radiographic follow-up. Comparisons were made using Fisher's exact, one-way analysis of variance, and chi(2) analyses. Results: There was no significant difference in either the overall prevalence of HO or the prevalence of moderate to severe HO in the two populations. Twenty of 35 (57.1%) limbs in the UK amputations developed HO compared with 134 of 213 (63%) in the US amputations (p > 0.05). The UK amputations had 12 cases (34.3%) of moderate to severe HO compared with 72 cases (33.8%) in the US amputations (p > 0.05). However, there was a significant difference in the number of UK amputations 0 of 20 (0%) versus the number of US amputations 25 of 134 (12%; p = 0.04), which required excision of symptomatic lesions. There was a significant association in the development of HO in UK personnel with the use of topical negative pressure treatment (p = 0.05) and increasing ISS scores (p = 0.04) and in the development of moderate to severe HO with increasing ISS (p = 0.006) and severe HI (p = 0.04). Unlike in the previous report, no significant association was found in UK personnel between any of the remaining hypothesized risk factors and either the presence or grade of HO. Conclusions: Although no difference was identified in the overall prevalence of HO, there are inconsistencies in the possible underlying causes of HO between the two cohorts. Further research is required in an ongoing effort to determine a causal relationship between treatment and subsequent HO formation. C1 [Brown, Kate V.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Dharm-Datta, Shresth; Etherington, John; Mistlin, Alan] Def Med Rehabil Ctr, Epsom, Surrey, England. [Potter, B. Kyle] Walter Reed Army Med Ctr, Amputee Patient Care Program, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Potter, B. Kyle] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Hsu, Joseph R.] Brooke Army Med Ctr, Dept Trauma & Orthopaed, Ft Sam Houston, TX 78234 USA. [Clasper, Jon C.] Acad Dept Mil Surg & Trauma, Birmingham, W Midlands, England. RP Brown, KV (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers, Ft Sam Houston, TX 78234 USA. EM kate.brown2@amedd.army.mil OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 29 TC 17 Z9 17 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S116 EP S122 DI 10.1097/TA.0b013e3181e44cc7 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000018 PM 20622605 ER PT J AU Brown, KV Murray, CK Clasper, JC AF Brown, Kate V. Murray, Clinton K. Clasper, Jon C. TI Infectious Complications of Combat-Related Mangled Extremity Injuries in the British Military SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE British military; Mangled extremity; Infection; Combat care; Combat; Acinetobacter; Staphylococcus aureus; Evacuation ID OPERATION IRAQI-FREEDOM; OPEN TIBIAL FRACTURES; WAR WOUNDS; ENDURING FREEDOM; EXTERNAL FIXATION; MANAGEMENT; EXPERIENCE; CASUALTIES; CLASSIFICATION; RECONSTRUCTION AB Background: During the wars in Iraq and Afghanistan, extremity injuries have predominated; however, no systematic review of field and stabilization care with subsequent infectious complications exists. This study evaluates the infectious complications and possible risk factors of British military casualties with mangled extremities, highlighting initial care and infections. Methods: This is a retrospective cohort study of British military casualties in Iraq and Afghanistan between August 2003 and May 2008. Casualties with mangled extremities undergoing limb salvage were evaluated for management strategies at the time of injury through evacuation back to the United Kingdom and subsequent infections. Results: There were 84 casualties with 85 extremities (20 infected and 65 uninfected). Infected extremities had more Gustilo Classification IIIb. There were no differences by Injury Severity Score, age, durations from injury to evacuation, or surgery, or arrival in England, use of clotting materials, or method of extremity stabilization between infected and uninfected extremity injuries. Tourniquet use in the field and fasciotomy were associated with infections. Antimicrobial coverage was associated with infections. Staphylococcus aureus were recovered later in casualties' clinical course in contrast to early recovery of Acinetobacter. On multivariate analysis, tourniquet in the field, antibiotics during evacuation and in the operating room, and fasciotomy were associated with infection as were certain bacteria, notably, Pseudomonas aeruginosa. Conclusion: Infections occurred in 24% of those with mangled extremities including 6% with osteomyelitis. Certain procedures, likely reflective of injury severity, were associated with infections along with certain bacteria, P. aeruginosa and possibly S. aureus. Continued clarification is required for antimicrobial coverage (penicillin-based regimens vs. additional anaerobic coverage) and certain surgical procedures to improve casualty care. C1 [Brown, Kate V.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Clasper, Jon C.] Selly Oak Hosp, Birmingham B29 6JD, W Midlands, England. [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. RP Brown, KV (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers,Suite B, Ft Sam Houston, TX 78234 USA. EM katevbrown@aol.com; Clinton.Murray@amedd.army.mil NR 47 TC 35 Z9 35 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S109 EP S115 DI 10.1097/TA.0b013e3181e4b33d PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000017 PM 20622604 ER PT J AU Butler, FK AF Butler, Frank K. TI Tactical Combat Casualty Care: Update 2009 SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID OPERATION-IRAQI-FREEDOM; CHEST-WALL THICKNESS; MAJOR LIMB TRAUMA; TOURNIQUET USE; NEEDLE; THORACOSTOMY; MANAGEMENT; DEATH; SWINE; MODEL C1 [Butler, Frank K.] USA, Inst Surg Res, For Sam Houston, TX USA. RP Butler, FK (reprint author), 4575 Lavallet Lane, Pensacola, FL 32504 USA. EM fkb064@yahoo.com NR 38 TC 39 Z9 39 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S10 EP S13 DI 10.1097/TA.0b013e3181e4220c PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000003 PM 20622602 ER PT J AU Chung, KK Salinas, J Renz, EM Alvarado, RA King, BT Barillo, DJ Cancio, LC Wolf, SE Blackbourne, LH AF Chung, Kevin K. Salinas, Jose Renz, Evan M. Alvarado, Ricardo A. King, Booker T. Barillo, David J. Cancio, Leopoldo C. Wolf, Steven E. Blackbourne, Lorne H. TI Simple Derivation of the Initial Fluid Rate for the Resuscitation of Severely Burned Adult Combat Casualties: In Silico Validation of the Rule of 10 SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Resuscitation; Adult burn patients; Fluid rate; Rule of 10 AB Background: In practice, current burn resuscitation formulas, designed to estimate 24-hour fluid resuscitation needs, provide only a starting point for resuscitation. To simplify this process, we devised the "rule of 10" to derive the initial fluid rate. Methods: We performed an in silico study to determine whether the rule of 10 would result in acceptable initial fluid rates for adult patients. A computer application using Java (Sun Microsystems Inc., Santa Clara, CA) generated a set of 100,000 random weights and percentage of total body surface area (%TBSA) values with distributions matching the model characteristics with which the initial fluid rate was calculated using the rule of 10. The initial rate for 100,000 simulations was compared with initial rates calculated by using either the modified Brooke (MB, 2 mL/kg/%TBSA) or the Parkland (PL, 4 mL/kg/%TBSA) formulas. Results: Analysis of calculated initial fluid rates using the rule of 10 showed that 87.8% (n = 87,840) of patients fell between the initial rates derived by the MB and the PL formulas. Less than 12% (n = 11,502) of patients had rule of 10 derived initial rates below the MB. Among these patients, the median difference of the initial rate was 14 mL/hr (range, 2-212 mL/hr). Among those who had initial rule of 10 calculated rates greater than the PL formula (<1%, n = 658), the median difference in rate was 33 mL/hr (range, 1-213 mL/hr), with a mean %TBSA of 21% +/- 1% and mean weight of 130 kg +/- 11 kg. Conclusion: For the majority of adult burn patients, the rule of 10 approximates the initial fluid rate within acceptable ranges. C1 [Chung, Kevin K.; Salinas, Jose; Renz, Evan M.; King, Booker T.; Barillo, David J.; Cancio, Leopoldo C.; Wolf, Steven E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Alvarado, Ricardo A.; Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM kevin.chung@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 16 TC 19 Z9 19 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S49 EP S54 DI 10.1097/TA.0b013e3181e425f1 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000008 PM 20622619 ER PT J AU Eastridge, BJ Wade, CE Spott, MA Costanzo, G Dunne, J Flaherty, S Holcomb, JB West, S Apodaca, A Blackbourne, L Casscells, SW AF Eastridge, Brian J. Wade, Charles E. Spott, Mary A. Costanzo, George Dunne, James Flaherty, Stephen Holcomb, John B. West, Susan Apodaca, Amy Blackbourne, Lorne Casscells, S. Ward TI Utilizing a Trauma Systems Approach to Benchmark and Improve Combat Casualty Care SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Benchmark; Trauma system; Trauma; Injury; Combat casualty care ID OPERATION-ENDURING-FREEDOM; INJURY-RELATED MORTALITY; RISK-ADJUSTED OUTCOMES; AFFAIRS SURGICAL RISK; NATIONAL EVALUATION; QUALITY; IMPLEMENTATION; RESUSCITATION; THEATER; TRIAGE AB Background: Derived from the necessity to improve the outcomes of soldiers injured on the battlefield, the U. S. military forces developed and implemented the Joint Theater Trauma System (JTTS) and the Joint Theater Trauma Registry based on U. S. civilian trauma system models. The purpose of this analysis was to develop battlefield injury outcome benchmark metrics and to evaluate the impact of JTTS-driven performance improvement interventions. Methods: To quantify these achievements, the Joint Theater Trauma Registry captured mechanistic, physiologic, diagnostic, therapeutic, and outcome data on 18,377 injured patients from January 2004 to May 2008 for analysis. Benchmarks were developed and statistically validated by using control chart methodology. Results: The majority (66.4%) of battlefield wounds were penetrating mechanism, 23.3% of all patients had an Injury Severity Score of >= 16, 21.8% had a base deficit of >= 5, 30.5% of patients required blood, and 6.8% required massive transfusion (>= 10 units red blood cell per 24 hours). In this severely injured population from the battlefield, the JTTS developed several pertinent benchmark metrics to assess quality of care associated with postinjury complications and mortality. The implementation of 27 JTTS-developed evidenced-based clinical practice guidelines and an improved information dissemination process was associated with a decrease in aggregate postinjury complications by 54%. Conclusions: Despite the numerous challenges of a global trauma system, the JTTS has set the standard for trauma care on the modern battlefield utilizing evidence-based medicine. The development of injury care benchmarks enhanced the evolution of the combat casualty care performance improvement process within the trauma system. C1 [Eastridge, Brian J.] USA, Inst Surg Res, MCMR SRJ, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Houston, Hlth Sci Ctr, Houston, TX USA. [Flaherty, Stephen] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Dunne, James] Bethesda Naval Med Ctr, Bethesda, MD USA. [Casscells, S. Ward] US Dept Def, Off Hlth Affairs, Washington, DC 20305 USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, MCMR SRJ, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 29 TC 32 Z9 33 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S5 EP S9 DI 10.1097/TA.0b013e3181e421f3 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000002 PM 20622620 ER PT J AU Edens, JW Chung, KK Pamplin, JC Allan, PF Jones, JA King, BT Cancio, LC Renz, EM Wolf, SE Wade, CE Holcomb, JB Blackbourne, LH AF Edens, Jason W. Chung, Kevin K. Pamplin, Jeremy C. Allan, Patrick F. Jones, John A. King, Booker T. Cancio, Leopoldo C. Renz, Evan M. Wolf, Steven E. Wade, Charles E. Holcomb, John B. Blackbourne, Lorne H. TI Predictors of Early Acute Lung Injury at a Combat Support Hospital: A Prospective Observational Study SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Fresh frozen plasma; Acute lung injury; Combat support hospital; Transfusion-related acute lung injury; Blood transfusion ID RESPIRATORY-DISTRESS-SYNDROME; FRESH-FROZEN PLASMA; DAMAGE CONTROL RESUSCITATION; INDEPENDENT RISK-FACTORS; ILL TRAUMA PATIENTS; BLOOD-TRANSFUSION; PULMONARY CONTUSION; CRITICALLY-ILL; BLUNT TRAUMA; CONSENSUS CONFERENCE AB Background: Acute lung injury (ALI) is a syndrome consisting of noncardiogenic acute hypoxemic respiratory failure with the presence of bilateral pulmonary infiltrates and occurs in up to 33% of critically ill trauma patients. Retrospective and observational studies have suggested that a blood component resuscitation strategy using equal ratios of packed red blood cells (PRBCs) and fresh frozen plasma (FFP) may have a survival benefit in combat casualties. The purpose of this study was to determine whether this strategy is associated with an increased incidence of ALI. Methods: We performed a prospective observational study of all injured patients admitted to an intensive care unit (ICU) at a combat support hospital who required >5 units of blood transfusion within the first 24 hours of admission. Baseline demographic data along with Injury Severity Score (ISS), pulmonary injury, presence of long bone fracture, blood products transfused, mechanical ventilation data, and arterial blood gas analysis were collected. The primary endpoint of the study was the development of ALI at 48 hours after injury. Those who did not survive to ICU admission were excluded from analysis. Follow-up (including mortality) longer than 48 hours was unavailable secondary to rapid transfer out of our facility. A multivariate logistic regression was performed to determine the independent effects of variables on the incidence of early ALI. Results: During a 12-month period (from January 2008 to December 2008), 87 subjects were studied; of these, 66 patients met inclusion criteria, and 22 patients developed ALI at 48 hours (33%). Overall, the ratio of FFP to PRBC was 1:1.1. Those who developed ALI had a higher ISS (32 +/- 15 vs. 26 +/- 11; p = 0.04) and received more units of FFP (22 +/- 15 vs. 12 +/- 7; p < 0.001), PRBCs (22 +/- 16 vs. 13 +/- 7; p = 0.008), and platelets (5 +/- 11 vs. 1 +/- 2; p = 0.004) compared with those who did not develop ALI. Multivariate logistic regression analysis revealed that presence of pulmonary injury (odds ratio, 5.4; 95% confidence interval, 1.3-21.9) and volume of FFP transfused (odds ratio, 1.2; 95% confidence interval, 1.1-1.3) had independent effects on ALI at 48 hours. Conclusion: On the basis of this small, prospective, descriptive study of severely injured patients admitted to the ICU, we determined that the presence of pulmonary injury had the greatest impact on the incidence of early ALI. There was also an independent relationship between the amount of FFP transfused and the incidence of early ALI. Further studies are required to determine the effects of the development of early ALI from FFP transfusion on short- and long-term survival. C1 [Edens, Jason W.; Chung, Kevin K.; Jones, John A.; King, Booker T.; Cancio, Leopoldo C.; Renz, Evan M.; Wolf, Steven E.; Wade, Charles E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Pamplin, Jeremy C.] Madigan Army Med Ctr, Ft Lewis, WA USA. [Allan, Patrick F.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Wolf, Steven E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr Houston, Houston, TX USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM Kevin.chung@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 38 TC 25 Z9 26 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S81 EP S86 DI 10.1097/TA.0b013e3181e44a32 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000013 PM 20622625 ER PT J AU Fang, R Dorlac, WC Flaherty, SF Tuman, C Cain, SM Popey, TLC Villard, DR Aydelotte, JD Dunne, JR Anderson, AM Powell, ET AF Fang, Raymond Dorlac, Warren C. Flaherty, Stephen F. Tuman, Caroline Cain, Steven M. Popey, Tracy L. C. Villard, Douglas R. Aydelotte, Jayson D. Dunne, James R. Anderson, Adam M. Powell, Elisha T. TI Feasibility of Negative Pressure Wound Therapy During Intercontinental Aeromedical Evacuation of Combat Casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Soft-tissue wounds; Aeromedical evacuation; Negative pressure; Military medicine; War; Wounds and injuries ID VACUUM-ASSISTED CLOSURE; SOFT-TISSUE INJURIES; EXPERIENCE; MANAGEMENT AB Objective: The objective of this study was to assess the feasibility of utilizing negative pressure wound therapy (NPWT) for the treatment of wartime soft-tissue wounds during intercontinental aeromedical evacuation. Background: Attempts to use NPWT during early phases of overseas contingency operations resulted in occasional vacuum system failures and potentially contributed to wound complications. These anecdotal episodes led to a perception that NPWT during aeromedical evacuation carried a high risk of wound complications and limited its use. As a result, NPWT was not frequently applied in the management of soft-tissue wounds before US casualty arrival in the continental United States (CONUS) for wounds sustained in the combat theaters. Concurrently, early NPWT on the traumatic wounds of host nation casualties not requiring aeromedical evacuation seemed to provide many benefits typically associated with the therapy such as decreased infection rates, earlier wound closure, and improved pain management. Methods: On a daily basis, study investigators reviewed the trauma inpatient census at Landstuhl Regional Medical Center, Germany, to identify patient candidates with soft-tissue extremity or torso wounds that required packing. Patient demographics, injuries, and previous wound treatments were recorded. Surgeons inspected wounds in the operating room and applied a NPWT dressing if deemed appropriate. NPWT was continued throughout the remainder of the patient's hospitalization and also during aeromedical evacuation to CONUS. A study investigator escorted the patient during aeromedical evacuation to educate the flight crews, to record the impact on crew workload, and to troubleshoot the system if necessary. Results: Thirty enrolled patients with 41 separate wounds flew from Germany to CONUS with a portable NPWT system (VAC Freedom System; Kinetic Concepts Incorporated, San Antonio, TX). All 30 patients arrived at the destination facilities with intact and functional systems. No significant in-flight complications were identified, impact on flight crew workload was negligible, and subjective feedback from both flight crews and patients was uniformly positive. For 29 patients, the NPWT dressing was replaced (frequently with serial exchanges) during initial surgical treatment in CONUS; the 30th patient underwent delayed primary closure of his right forearm fasciotomy. Receiving care teams reported no complications attributable to NPWT during aeromedical vacuation. Conclusions: NPWT is feasible during intercontinental aeromedical evacuation of combat casualties without an increase in wound complications or a significant impact on air crew workload. Further studies are indicated to evaluate the efficacy of NPWT in combat wounds compared with other wound care techniques. C1 [Fang, Raymond; Tuman, Caroline; Cain, Steven M.; Popey, Tracy L. C.; Villard, Douglas R.] Landstuhl Reg Med Ctr, Landstuhl, Germany. [Dorlac, Warren C.] Univ Cincinnati, Cincinnati, OH USA. [Flaherty, Stephen F.; Aydelotte, Jayson D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Dunne, James R.] Natl Naval Med Ctr, Bethesda, MD USA. [Powell, Elisha T.] Alaska Reg Hosp, Anchorage, AK USA. RP Fang, R (reprint author), LRMC Trauma Program, CMR 402, APO, AE 09180 USA. EM Raymond.Fang@amedd.army.mil NR 21 TC 20 Z9 20 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S140 EP S145 DI 10.1097/TA.0b013e3181e452a2 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000021 PM 20622609 ER PT J AU Fox, CJ Perkins, JG Kragh, JF Singh, NN Patel, B Ficke, JR AF Fox, Charles J. Perkins, Jeremy G. Kragh, John F., Jr. Singh, Niten N. Patel, Bhavin Ficke, James R. TI Popliteal Artery Repair in Massively Transfused Military Trauma Casualties: A Pursuit to Save Life and Limb SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Vascular trauma; Massive transfusion; Damage control; Resuscitation; Combat; Wartime; Military ID DAMAGE CONTROL RESUSCITATION; LOWER-EXTREMITY TRAUMA; VASCULAR INJURY; GLOBAL WAR; EXPERIENCE; MANAGEMENT; AMPUTATION; BATTLEFIELD; AFGHANISTAN; STRATEGY AB Background: Popliteal artery war wounds can bleed severely and historically have high rates of amputation associated with ligation (72%) and repair (32%). More than before, casualties are now surviving the initial medical evacuation and presenting with severely injured limbs that prompt immediate limb salvage decisions in the midst of life-saving maneuvers. A modern analysis of current results may show important changes because previous limb salvage strategies were limited by the resuscitation and surgical techniques of their eras. Because exact comparisons between wars are difficult, the objective of this study was to calculate a worst-case (a pulseless, fractured limb with massive hemorrhage from popliteal artery injury) amputation-free survival rate for the most severely wounded soldiers undergoing immediate reconstruction to save both life and limb. Methods: We performed a retrospective study of trauma casualties admitted to the combat support hospital at Ibn Sina Hospital in Baghdad, Iraq, between 2003 and 2007. US military casualties requiring a massive transfusion (>= 10 blood units transfused within 24 hours of injury) were identified. We extracted data on the subset of casualties with a penetrating supra or infrageniculate popliteal arterial vascular injury. Demographics, injury mechanism, Injury Severity Score, tourniquet use, physiologic parameters, damage control adjuncts, surgical repair techniques, operative time, and outcomes (all-cause 30-day mortality, amputation rates, limb salvage failure, and graft patency) were investigated. Results: Forty-six massively transfused male casualties, median age 24 years (range, 19-54 years; mean Injury Severity Score, 19 +/- 8.0), underwent immediate orthopedic stabilization and vascular reconstruction. There was one early death. The median operative time for the vascular repairs was 217 minutes (range, 94-630 minutes) and included all damage control procedures. Combined arterial and venous injuries occurred in 17 (37%). Ligation was performed for no arterial and 9 venous injuries. Amputations (transtibial or transfemoral) were considered limb salvage failures (14 of 48, 29.2%) and were grouped as immediate (<= 48 hours, 5), early (>48 hours and <= 30 days, 6), or late (>30 days, 3). Limb losses were from graft thrombosis, infection, or chronic pain. Combined arterial and venous injuries occurred in 17 (37%). Ligation was performed for no arterial and nine venous injuries. For a median follow-up (excluding death) of 48 months (range, 23-75 months), the amputation-free survival rate was 67%. Conclusions: This study, a worst-case study, showed comparable results to historical controls regarding limb salvage rates (71% for Iraq vs. 56-69% for the Vietnam War). Thirty-day survival (98%), 4-year amputation-free survival (67%), and complication-free rates (35%) fill knowledge gaps. Guidelines for managing popliteal artery injuries show promising results because current resuscitation practices and surgical care yielded similar amputation rates to prior conflicts despite more severe injuries. Significant transfusion requirements and injury severity may not indicate a life-over-limb strategy for popliteal arterial repairs. Future studies of limb salvage failures may help improve casualty care by reducing the complications that directly impact amputation-free survival. C1 [Fox, Charles J.] Walter Reed Army Med Ctr, Div Vasc Surg, Program Director Vasc Surg, Dept Surg, Washington, DC 20307 USA. [Fox, Charles J.] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Bethesda, MD 20814 USA. [Perkins, Jeremy G.] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD USA. [Kragh, John F., Jr.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Singh, Niten N.] Madigan Army Med Ctr, Dept Surg, Div Vasc Surg, Tacoma, WA 98431 USA. [Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. RP Fox, CJ (reprint author), Walter Reed Army Med Ctr, Div Vasc Surg, Program Director Vasc Surg, Dept Surg, Bldg 2,Ward 64,6900 Georgia Ave NW, Washington, DC 20307 USA. EM Charles.Fox@us.army.mil OI Patel, Bhavin/0000-0002-0877-1067 NR 42 TC 15 Z9 16 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S123 EP S134 DI 10.1097/TA.0b013e3181e44e6d PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000019 PM 20622606 ER PT J AU Hospenthal, DR Crouch, HK English, JF Leach, F Pool, J Conger, NG Whitman, TJ Wortmann, GW Murray, CK Cordts, PR Gamble, WB AF Hospenthal, Duane R. Crouch, Helen K. English, Judith F. Leach, Fluryanne Pool, Jane Conger, Nicholas G. Whitman, Timothy J. Wortmann, Glenn W. Murray, Clinton K. Cordts, Paul R. Gamble, W. Bryan TI Response to Infection Control Challenges in the Deployed Setting: Operations Iraqi and Enduring Freedom SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Infection prevention and control; Infection; Military; Combat; Trauma ID US ARMY SOLDIERS; ACINETOBACTER-BAUMANNII; COLONIZATION; CASUALTIES; RECOVERY; OUTBREAK; TRAUMA AB Background: Infections caused by multidrug-resistant organisms (MDROs), including Acinetobacter, have complicated the care of military personnel injured in Operations Iraqi and Enduring Freedom. Cumulative data suggest that nosocomial transmission of MDROs in deployed medical treatment facilities (MTFs) has contributed to these infections. A 2008 review of deployed MTFs identified multiple factors impeding the performance of infection prevention and control (IC) practices. In response, efforts to emphasize IC basics, improve expertise, and better track MDRO colonization were pursued. Methods: Efforts to increase awareness and enhance IC in deployed MTFs were focused on educating leaders and deploying personnel, producing deployed IC resources, and standardizing level IV and V admission screening for MDRO colonization. A repeat mission in 2009 reviewed interval progress. Results: Increased awareness and the need for emphasis on basic IC practice, including hand hygiene, use of transmission-based (isolation) precautions, and cohorting of patients, were imparted to leaders and deploying personnel through briefings, presentations, and an All Army Activities message. Enhancement of IC expertise was implemented through increased standardization of IC practice, establishment of a predeployment IC short course, an IC teleconsultation service, and dedicated Internet resources. Standardization of admission colonization screening of personnel evacuated from the combat theater was established to better define and respond to the MDRO problem. A repeat review of the deployed MTFs found overall improvement in IC practice, including clear command emphasis in the Iraqi theater of operations. Conclusions: Maintaining a strong IC effort in the deployed setting, even in a stabilized operational environment, is difficult. Use of innovative strategies to enhance expertise and practice were implemented to reduce MDRO infections. C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, Ft Sam Houston, TX 78234 USA. [Crouch, Helen K.] Brooke Army Med Ctr, Infect Control Serv, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.; Wortmann, Glenn W.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA. [English, Judith F.] USN, Bur Med & Surg, Washington, DC USA. [Leach, Fluryanne] Walter Reed Army Med Ctr, Infect Control Serv, Washington, DC 20307 USA. [Wortmann, Glenn W.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Pool, Jane] Landstuhl Reg Med Ctr, Infect Control Div, Ramstein AFB, Germany. [Conger, Nicholas G.] Landstuhl Reg Med Ctr, Div Infect Dis, Ramstein AFB, Germany. [Cordts, Paul R.] USA, Hlth Policy Serv, Off Surg Gen, Falls Church, VA USA. [Whitman, Timothy J.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Gamble, W. Bryan] US Cent Command, Command Surg Off, MacDill AFB, FL USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil NR 15 TC 13 Z9 13 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S94 EP S101 DI 10.1097/TA.0b013e3181e44b3f PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000015 PM 20622627 ER PT J AU Larson, CR White, CE Spinella, PC Jones, JA Holcomb, JB Blackbourne, LH Wade, CE AF Larson, Claire R. White, Christopher E. Spinella, Philip C. Jones, John A. Holcomb, John B. Blackbourne, Lorne H. Wade, Charles E. TI Association of Shock, Coagulopathy, and Initial Vital Signs With Massive Transfusion in Combat Casualties SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Massive transfusion; Plasma; Trauma; Hemorrhage; Shock; Coagulopathy ID TRAUMA EXSANGUINATION PROTOCOL; DAMAGE CONTROL RESUSCITATION; BLOOD-PRODUCT UTILIZATION; 110 MM HG; REDEFINING HYPOTENSION; CONTROL HEMATOLOGY; MORTALITY; PLASMA; IMPACT; RATIO AB Background: Timely initiation of a massive transfusion (MT) protocol is associated with improved survival and reduced transfusion for patients requiring MT; however, a priori identification of this population is difficult. The objective of this study was to compare the results of an MT prediction model and actual MT incidence in combat casualties. Methods: We performed a retrospective review of the Joint Theater Trauma Registry transfusion database for all US service personnel injured in combat during overseas contingency operations who received at least 1 unit of blood. Systolic blood pressure at the time of admission, heart rate, hemoglobin, international normalized ratio, and base deficit were used in a previously developed prediction model for MT. Results: Casualties (n = 1124) were identified who had received at least 1 unit of blood and had all data points. Of these patients, 420 patients (37%) received an MT. Subjects presenting with any two of four possible variables (heart rate >110, systolic blood pressure <110 mm Hg, base deficit <=-6, and hemoglobin <11) had a 54% incidence of MT with a model sensitivity of 69%. Patients predicted but not observed to receive an MT had earlier time of death and an increased incidence of head injuries compared with those predicted and observed to receive an MT. Patients not predicted but observed to receive an MT had increased chest, abdominal, and extremity injuries than those neither predicted nor observed to receive an MT. Conclusion: The decision to implement an MT seems to rely heavily on clinical evaluation of severity of abdominal and extremity injury rather than physiologic derangement. Using a model based on the physiologic parameters-a more objective measure-may decrease mortality in combat casualties. C1 [Larson, Claire R.; White, Christopher E.; Spinella, Philip C.; Jones, John A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Dept Surg, Ft Sam Houston, TX 78234 USA. [Spinella, Philip C.] Childrens Med Ctr, Dept Pediat, Hartford, CT USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Houston, Hlth Sci Ctr, Ctr Translat Injury Res, Houston, TX USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Houston, Hlth Sci Ctr, Dept Surg, Houston, TX USA. RP Larson, CR (reprint author), USA, Inst Surg Res, Dept Surg, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM larsonc@uthscsa.edu NR 48 TC 27 Z9 27 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S26 EP S32 DI 10.1097/TA.0b013e3181e423f4 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000005 PM 20622616 ER PT J AU Murray, CK Griffith, ME Mende, K Guymon, CH Ellis, MW Beckius, M Zera, WC Yu, X Co, EMA Aldous, W Hospenthal, DR AF Murray, Clinton K. Griffith, Matthew E. Mende, Katrin Guymon, Charles H. Ellis, Michael W. Beckius, Miriam Zera, Wendy C. Yu, Xin Co, Edgie-Mark A. Aldous, Wade Hospenthal, Duane R. TI Methicillin-Resistant Staphylococcus aureus in Wound Cultures Recovered From a Combat Support Hospital in Iraq SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE MRSA; Wound; Iraq; USA300; Antibiotics; Community acquired; Hospital acquired ID SOFT-TISSUE INFECTIONS; WAR WOUNDS; UNITED-STATES; MOLECULAR EPIDEMIOLOGY; MILITARY PERSONNEL; UNCOMPLICATED SKIN; CONTROLLED-TRIAL; STRAINS; BACTERIOLOGY; CASUALTIES AB Background: Staphylococcus aureus infections complicate care of combat-related injuries and can independently result in skin and soft-tissue infections during deployments or training. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains seem to produce severe disease but retain susceptibility to many oral antimicrobials. This study characterizes 84 MRSA isolates recovered from wound cultures at a combat support hospital in Iraq. Methods: MRSA strains recovered from December 2007 through March 2009 were analyzed. Antimicrobial resistance testing was determined by broth microdilution and the BD Phoenix Automated Microbiology System. The genotypic pattern was analyzed by pulsed-field gel electrophoresis and polymerase chain reaction identification of resistance and virulence genes. Results: No MRSA isolates from wound cultures were resistant to vancomycin. The most active oral antistaphylococcal agents were tetracycline (95% susceptibility), trimethoprim-sulfamethoxazole (94%), and clindamycin (94%). Of agents not typically recommended as monotherapy, 98% of isolates were susceptible to rifampin, 91% to moxifloxacin, and 60% to levofloxacin. The most common pulsed-field type (PFT) was USA300 (79%). The typical staphylococcal cassette chromosome mec IV elements carrying the CA-MRSA resistance genes were present in 88% of the isolates. Panton-Valentine leukocidin virulence genes were identified in 88% of isolates, including 100% of PFT USA300. The virulence gene associated with an arginine catabolic mobile element was present in 75% of isolates, including 94% of PFT USA300. Conclusion: This study is the first genotypic and phenotypic characterization of CA-MRSA recovered from wound cultures in a deployed combat hospital. The pattern noted was similar to that seen in soldiers stationed in the United States. C1 [Murray, Clinton K.] Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.; Griffith, Matthew E.; Mende, Katrin; Ellis, Michael W.; Hospenthal, Duane R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Mende, Katrin; Zera, Wendy C.] Infect Dis Clin Res Program, Bethesda, MD USA. [Guymon, Charles H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Beckius, Miriam; Yu, Xin] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, San Antonio Mil Med Ctr, Infect Dis Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 53 TC 9 Z9 9 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S102 EP S108 DI 10.1097/TA.0b013e3181e44b57 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000016 PM 20622603 ER PT J AU Nesbitt, M Allen, P Beekley, A Butler, F Eastridge, B Blackbourne, L AF Nesbitt, Michael Allen, Paul Beekley, Alec Butler, Frank Eastridge, Brian Blackbourne, Lorne TI Current Practice of Thermoregulation During the Transport of Combat Wounded SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Hypothermia; Combat trauma; Thermoregulation; Thermoregulatory technique; Casualty evacuation ID HYPOTHERMIA; MORTALITY; INJURY; TRANSFUSION; PATIENT; CARE AB Background: This study evaluated the progress in the treatment and prevention of hypothermia in combat wounded since the October 2, 2006 Joint Theater Trauma System Clinical Practice Guideline (CPG) publication and evaluated the frequency of use and effectiveness of the methods described in the CPG. Methods: The authors used data obtained from the Joint Trauma Theater Trauma Registry maintained by the US Army Institute of Surgical Research for our analysis. Results: The issuance of the CPG was associated with a decrease in the incidence of hypothermia (p value = <0.0001). None of the thermoregulatory methods were associated with significantly higher overall temperatures when compared with the others (p value = 0.1062-0.3686) or with hypothermia (p value = 0.1367-0.7992); however, lack of entered prehospital data resulted in a suboptimal number of patients for evaluation in this portion of the study. The wool blanket was the most commonly used thermoregulatory method (prehospital, 72%; interfacility, 49%). Conclusions: (1) The incidence of hypothermia decreased after the issuance of the JTTS CPG. (2) The standard Army wool blanket is the most commonly used thermoregulatory method during transport in theater. (3) This study did not find a significant difference in the capability of maintaining temperatures between the different thermoregulatory methods used in theater during either prehospital or interfacility transport, or in the incidence of hypothermia between patients presenting from the site of injury or from interfacility transport. (4) Data collected before a Level III facility is not consistently entered into the Joint Theater Trauma Registry. C1 [Nesbitt, Michael; Allen, Paul] Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. [Beekley, Alec] Madigan Army Med Ctr, Uniformed Serv Univ Hlth Sci Chief Acting, Ft Lewis, WA USA. [Butler, Frank] USA, Comm Tact Combat Casualty Care, Def Hlth Board, Ft Sam Houston, TX USA. [Eastridge, Brian] USA, Joint Trauma Syst Programs, Ft Sam Houston, TX USA. [Blackbourne, Lorne] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Nesbitt, M (reprint author), Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX 78234 USA. EM mike.nesbitt@us.army.mil NR 21 TC 9 Z9 11 U1 1 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S162 EP S167 DI 10.1097/TA.0b013e3181e45b83 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000024 PM 20622612 ER PT J AU Possley, DR Burns, TC Stinner, DJ Murray, CK Wenke, JC Hsu, JR AF Possley, Daniel R. Burns, Travis C. Stinner, Daniel J. Murray, Clinton K. Wenke, Joseph C. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Temporary External Fixation Is Safe in a Combat Environment SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE External fixation; Damage control; Open fractures; Combat ID OPEN FRACTURES; WIRE PLACEMENT; LONG BONES; COMPLICATIONS; MANAGEMENT; INFECTION; INJURIES; TIBIA; LIMB; WAR AB Background: External fixation has been used extensively during recent wars as a damage control measure for fractures in coalition forces being evacuated. We hypothesize that external fixation is a safe and effective initial stabilization procedure for combat-related open fractures. Methods: Records on 55 consecutive type III tibia fractures between March 2003 and September 2007 were reviewed. We stratified the complications related to external fixation as major, potential, and minor complications. We defined major complications as neurovascular injury, mechanical failure, septic joint, and pin tract osteomyelitis. Potential complications were defined as pins within 1 inch of the fracture, pin overpenetration (>= 26 mm), pin without cortical purchase, and intracapsular pin placement. Minor complications were defined as pin tract infections, addition of pins or bars, and pin overpenetration (9-25 mm). "Successful application" was defined as the absence of major or potential complications. Results: We recorded no major complications. There were 12 of 53 (22.6%) constructs and 21 of 228 (9.2%) pins inserted with potential complications. We detected minor complications in 27 of 53 (50.9%) constructs and 35 of 228 (15.3%) pins inserted; 41 of 53 (77.4%) constructs had no major or potential complications. Conclusions: Treatment of combat-related open tibia fractures with external fixation was 77% successful in our series. We recorded no major complications but demonstrated the possibility for technical improvement in one of the five constructs with potential complications. Despite the recorded potential and minor complications, external fixation is safe and effective as a temporary damage control in open fractures sustained in combat. C1 [Possley, Daniel R.; Burns, Travis C.; Stinner, Daniel J.; Murray, Clinton K.; Wenke, Joseph C.; Hsu, Joseph R.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Possley, Daniel R.; Burns, Travis C.; Stinner, Daniel J.; Hsu, Joseph R.] Brooke Army Med Ctr, Dept Orthopaed, Ft Sam Houston, TX 78234 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Dept Infect Dis, Ft Sam Houston, TX 78234 USA. RP Possley, DR (reprint author), USA, Inst Surg Res, Bldg 3611,3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM daniel.possley@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 35 TC 16 Z9 16 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S135 EP S139 DI 10.1097/TA.0b013e3181e44fcb PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000020 PM 20622607 ER PT J AU Sambasivan, CN Underwood, SJ Cho, SD Kiraly, LN Hamilton, GJ Kofoed, JT Flaherty, SF Dorlac, WC Schreiber, MA AF Sambasivan, Chitra N. Underwood, Samantha J. Cho, S. D. Kiraly, Laszlo N. Hamilton, Greg J. Kofoed, J. T. Flaherty, Stephen F. Dorlac, Warren C. Schreiber, Martin A. TI Comparison of Abdominal Damage Control Surgery in Combat Versus Civilian Trauma SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Damage control surgery; Open abdomen; Combat trauma; Civilian trauma ID FASCIAL CLOSURE; UNITED-STATES; OPEN ABDOMEN; INJURY; WAR; EXPERIENCE; MANAGEMENT; DEATH AB Background: The majority of individuals who perform damage control surgery in the military arena are trained in civilian venues. Therefore, it is important to compare and contrast damage control performed in civilian and military settings. In contrast to civilian trauma, which is primarily caused by blunt injury and addressed at one or two surgical facilities, combat casualties primarily sustain explosion-related injuries and undergo treatment at multiple levels of care across continents. We aimed to compare patients undergoing abdominal damage control surgery across these two very different settings. Methods: Parallel retrospective reviews were conducted over 2 years (2005-2006) in a combat setting and at a US Level I trauma center. Patients were examined during the first 7 days after injury. Results: The civilian population (CP) was older (40 vs. 23; p < 0.01) with a higher injury severity score (35 vs. 27; p < 0.02). The CP experienced greater blunt injury than the military population (MP) (83 vs. 4%; p < 0.01). Explosion-related injury was only present in the MP (64%). At baseline, the CP presented with lower systolic blood pressure (108 vs. 126) and larger base deficit (9.8 vs. 6.5; p < 0.05). The MP underwent more surgeries (3.5 vs. 2.9; p = 0.02) with similar rates of fascial closure (48.7% vs. 70.0%; p = 0.11). Complication rates were similar between the CP and the MP (43% vs. 58%, respectively; p = 0.14). Conclusions: Military and civilian trauma patients who undergo damage control surgery experience similar fascial closure rates despite differing demographics and widely disparate mechanisms of injury. The MP undergoes a greater number of procedures than the CP, but complication rates do not differ between the groups. C1 [Sambasivan, Chitra N.; Underwood, Samantha J.; Cho, S. D.; Kiraly, Laszlo N.; Hamilton, Greg J.; Kofoed, J. T.; Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Portland, OR 97239 USA. [Flaherty, Stephen F.] Walter Reed Army Med Ctr, Gen Surg Serv, Washington, DC 20307 USA. [Dorlac, Warren C.] Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Schreiber, MA (reprint author), Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, 3181 SW Sam Jackson Pk Rd,Mail Code L611, Portland, OR 97239 USA. EM schreibm@ohsu.edu NR 21 TC 6 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S168 EP S174 DI 10.1097/TA.0b013e3181e45cef PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000025 PM 20622613 ER PT J AU Serkin, FB Soderdahl, DW Hernandez, J Patterson, M Blackbourne, L Wade, CE AF Serkin, Faye B. Soderdahl, Douglas W. Hernandez, Javier Patterson, Maria Blackbourne, Lorne Wade, Charles E. TI Combat Urologic Trauma in US Military Overseas Contingency Operations SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Genitourinary injuries; OCO; JTTR ID IRAQI FREEDOM; ENDURING FREEDOM; UROGENITAL INJURIES; URETERAL INJURIES; WAR INJURIES; MANAGEMENT; EXPERIENCE; EXPLOSIONS; DIAGNOSIS; THEATER AB Background: This article reports on the occurrences and patterns of genitourinary (GU) trauma in the contemporary high-intensity conflict of the overseas contingency operations (OCOs). methods: The Joint Theater Trauma Registry was queried for all US military members who received treatment for GU wounds and concomitant injuries sustained in OCOs for > 75 months between October 2001 and January 2008. Results: Of the 16,323 trauma admissions annotated in the Joint Theater Trauma Registry, 819 (5%) had one or more GU injuries. Of the GU casualties, 90% were sustained in Iraq and 65% were because of explosions. The average casualty age was 26 years (range, 18-58 years) and 98.5% were men. There were 887 unique GU injuries distributed as follows: scrotum, 257 (29.0%); kidney, 203 (22.9%); bladder, 189 (21.3%); penis, 126 (14.2%); testicle, 81 (9.1%); ureter, 24 (2.7%); and urethra, 7 (0.8%). Of the 203 patients with kidney injuries, 22% went to the operating room with 31 patients having nephrectomies. There were 189 bladder injuries with 26 patients (14%) having concomitant pelvic fractures. Conclusions: This is the largest report of GU injuries during any military conflict. The distribution and percentage of casualties with GU injuries in the OCO are similar to those of previous conflicts. Consideration should be given to personnel protective equipment for the areas associated with GU injuries and predeployment training directed at the care of these injuries. C1 [Serkin, Faye B.; Soderdahl, Douglas W.; Hernandez, Javier; Patterson, Maria] San Antonio Mil Med Ctr, Dept Urol, Ft Sam Houston, TX USA. [Blackbourne, Lorne; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX USA. RP Serkin, FB (reprint author), Wilford Hall USAF Med Ctr, Dept Urol MCSU, Lackland AFB, TX 78236 USA. EM fayeserkin@yahoo.com FU Institute of Surgical Research FX Supported by the Institute of Surgical Research. NR 34 TC 22 Z9 22 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S175 EP S178 DI 10.1097/TA.0b013e3181e45cd1 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000026 PM 20622614 ER PT J AU Simmons, JW White, CE Eastridge, BJ Mace, JE Wade, CE Blackbourne, LH AF Simmons, John W. White, Christopher E. Eastridge, Brian J. Mace, James E. Wade, Charles E. Blackbourne, Lorne H. TI Impact of Policy Change on US Army Combat Transfusion Practices SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Trauma; Trauma systems; Clinical practice guideline; Damage control resuscitation ID DAMAGE CONTROL RESUSCITATION; INTENSIVE-CARE-UNIT; I TRAUMA CENTER; RED-BLOOD-CELL; OPERATION IRAQI FREEDOM; INJURY SEVERITY SCORE; LAST 60 YEARS; MASSIVE TRANSFUSION; IMPROVES OUTCOMES; IMPROVED SURVIVAL AB Background: Clinical practice guidelines (CPGs) are used to keep providers up-to-date with the most recent literature and to guide in decision making. Adherence is typically improved although many have a muted impact. In March 2006, the US Army issued a damage control resuscitation CPG, encouraging 1: 1 plasma: red blood cell (RBC) transfusions and limiting crystalloid use. The objective of this study was to determine whether the CPG was associated with a change in the transfusion practices in combat-wounded patients. Methods: All US service members injured in Operation Iraqi Freedom/Operation Enduring Freedom who received massive transfusions (MTs; >= 10 RBC in 24 hours) were queried from the US Army Institute of Surgical Research transfusion database. Whole blood, when used, was counted as 1 unit of RBC, fresh frozen plasma (FFP), and platelet. Subjects were divided into pre- and post-CPG cohorts. Primary outcomes were ratios of FFP: RBC and crystalloid use. Results: A total of 777 MT patients were identified. The cohorts were similar in age (25 years +/- 6 years vs. 25 years +/- 6 years; p = ns) and injury severity scale score (24 +/- 12 vs. 25 +/- 12; p = ns). The post-CPG cohort was warmer (96.5 degrees F +/- 7.8 degrees F vs. 98.2 degrees F +/- 1.9 degrees F; p < 0.05) and was transfused more RBC, platelets, and plasma but received less crystalloid (17 units +/- 12 units vs. 19 units +/- 11 units, 1 unit +/- 2 units vs. 2 units +/- 3 units, 8 units +/- 8 units vs. 14 units +/- 11 units, 14 L +/- 14 L vs. 9 L +/- 13 L, respectively; p < 0.05). The post-CPG cohort also received a higher ratio transfusion (0.5 +/- 0.31 vs. 0.8 +/- 0.31; p < 0.05) representing a change in practice. Overall mortality was not different between the two groups (24 vs. 19%; p = 0.115). Conclusions: MT patients are now receiving a higher FFP: RBC ratio and less crystalloid after implementation of the CPG. Additionally, patients are now presenting normothermic and have higher hemoglobin levels. All of these changes are consistent with the principles of damage control resuscitation. Changes in practice were associated with implementation of the CPG, maturity of the battlefield, and increased availability of products. C1 [Simmons, John W.; White, Christopher E.; Eastridge, Brian J.; Mace, James E.; Wade, Charles E.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Simmons, JW (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.simmons@amedd.army.mil NR 45 TC 35 Z9 36 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S75 EP S80 DI 10.1097/TA.0b013e3181e44952 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000012 PM 20622624 ER PT J AU Van, PY Sambasivan, CN Wade, CE Jones, JA Holcomb, JB Schreiber, MA Blackbourne, LH AF Van, Philbert Y. Sambasivan, Chitra N. Wade, Charles E. Jones, John A. Holcomb, John B. Schreiber, Martin A. Blackbourne, Lorne H. TI High Transfusion Ratios Are Not Associated With Increased Complication Rates in Patients With Severe Extremity Injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Extremity injury; Damage control resuscitation; Combat injuries ID DAMAGE CONTROL RESUSCITATION; ACUTE TRAUMATIC COAGULOPATHY; COMBAT-RELATED CASUALTIES; ACTIVATED FACTOR-VII; FRESH-FROZEN PLASMA; MASSIVE TRANSFUSION; MORTALITY; SURVIVAL; HYPOPERFUSION; PLATELET AB Background: High transfusion ratios of plasma to packed red blood cells (>1:2) have been associated with increased survival and increased complications in patients receiving massive transfusion (MT). We hypothesized that high ratio transfusion would be associated with no survival benefit and increased complications in combat victims with compressible hemorrhage. Methods: A retrospective analysis of soldiers injured in the current conflict during 5 years (n = 2,105) who received blood was performed on those with isolated extremity (abbreviated injury scale extremity score >= 3 and abbreviated injury scale score 0-2 in all other regions) injury comparing those who received a MT with those who did not. Transfusion ratios in the first 24 hours were correlated with outcomes. Results: Injury severity score (14.6 vs. 12.1; p < 0.05), international normalized ratio (1.65 vs. 1.28; p < 0.05), and base deficit (8.0 vs. 3.7; p < 0.05) were higher in the MT group. High transfusion ratios were associated with a trend toward decreased mortality (17.2% vs. 6.9%; p = 0.07) in MT patients and no increased complications (20.7% vs. 26.4%; p > 0.05). In those receiving a non-MT, high ratios were associated with similar mortality (4.8% vs. 3.9%; p > 0.05) and complications (12.4% vs. 9.2%; p > 0.05). Conclusions: Extremity injured patients receiving MT may benefit from high transfusion ratios and do not experience increased complications. No change in mortality or complications was observed in non-MT patients across transfusions ratios. High transfusion ratios are not associated with increased complications in patients with isolated extremity injury regardless of whether a MT is required. C1 [Van, Philbert Y.; Sambasivan, Chitra N.; Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Portland, OR 97239 USA. [Wade, Charles E.; Jones, John A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Houston Hlth Sci Ctr, Div Acute Care Surg, Houston, TX USA. RP Schreiber, MA (reprint author), Oregon Hlth & Sci Univ, Div Trauma & Crit Care, 3181 SW Sam Jackson Pk Rd,Mail Code L611, Portland, OR 97239 USA. EM schreibm@ohsu.edu NR 33 TC 8 Z9 8 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S64 EP S68 DI 10.1097/TA.0b013e3181e453ec PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000010 PM 20622622 ER PT J AU Voelckel, WG Convertino, VA Lurie, KG Karlbauer, A Schochl, H Lindner, KH Trimmel, H AF Voelckel, Wolfgang G. Convertino, Victor A. Lurie, Keith G. Karlbauer, Alois Schoechl, Herbert Lindner, Karl-Heinz Trimmel, Helmut TI Vasopressin for Hemorrhagic Shock Management: Revisiting the Potential Value in Civilian and Combat Casualty Care SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Civilian; Combat; Hemorrhage; Shock; Exsanguination; Resuscitation; Arginine vasopressin ID ORGAN BLOOD-FLOW; ARGININE-VASOPRESSIN; LIVER TRAUMA; CARDIOPULMONARY-RESUSCITATION; FLUID RESUSCITATION; VASODILATORY SHOCK; IMPROVES SURVIVAL; HYPOTENSION; MODEL; DOGS AB The evolution of trauma care is driven by a synergistic relationship between civilian and military medical systems. Although the characteristics of civilian injuries differ from those encountered on the battlefield, the pathophysiologic process of dying is the same and dominated by exsanguination and central nervous trauma. As such, therapies that interfere with the physiologic ability to compensate hemorrhage may play a key role to buy time until hemostatic surgery can be initiated. From a variety of remedies with the potential to prolong the compensation phase or to reverse the decompensation phase of shock, arginine vasopressin (AVP) is one of the most promising and best-evaluated drugs. Animal studies and various case report series provide some evidence that AVP may improve blood pressure even when conventional therapies fail, thus preventing hypovolemic cardiac arrest and enabling resuscitation from fatal hemorrhage. On the basis of this civilian experience, it seems reasonable to consider AVP for hypotensive resuscitation in the austere, resource-constrained battlefield environment. However, the significance of AVP as a rescue medication for life-threatening hemorrhage has yet to be proven. C1 [Voelckel, Wolfgang G.; Schoechl, Herbert] AUVA Trauma Ctr Salzburg, Dept Anesthesiol & Crit Care Med, A-5010 Salzburg, Austria. [Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Lurie, Keith G.] Univ Minnesota, Dept Emergency Med, Minneapolis, MN USA. [Lindner, Karl-Heinz] Med Univ, Dept Anesthesiol & Crit Care Med, Innsbruck, Austria. [Karlbauer, Alois] AUVA Trauma Ctr Salzburg, Dept Traumatol, A-5010 Salzburg, Austria. [Trimmel, Helmut] Wiener Neustadt Gen Hosp, Dept Anesthesiol & Crit Care Med, Weiner, Austria. RP Voelckel, WG (reprint author), AUVA Trauma Ctr Salzburg, Dept Anesthesiol & Crit Care Med, Dr Franz Rehrl Pl 5, A-5010 Salzburg, Austria. EM wolfgang.voelckel@auva.at NR 43 TC 13 Z9 14 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUL PY 2010 VL 69 SU 1 BP S69 EP S74 DI 10.1097/TA.0b013e3181e44937 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 627AC UT WOS:000280009000011 PM 20622623 ER PT J AU Freeman, RJ Mancuso, JD Riddle, MS Keep, LW AF Freeman, Randall J. Mancuso, James D. Riddle, Mark S. Keep, Lisa W. TI Systematic Review and Meta-Analysis of TST Conversion Risk in Deployed Military and Long-Term Civilian Travelers SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID TUBERCULIN SKIN-TEST; MYCOBACTERIUM-TUBERCULOSIS; INFECTION; AREAS; PREVALENCE; BURDEN; ARMY AB Methods. We performed a systematic review to acquire all published and unpublished data on TST conversion in long-term civilian and military travelers from 1990 to June 2008. Point estimates and confidence intervals (CIs) of the incidence of TST conversion were combined in a random effects model and assessed for heterogeneity. Results. The cumulative risk with CI for LTBI as measured by TST conversion was 2.0% (99% CI: 1.6%-2.4%). There was a marked heterogeneity (chi 2 heterogeneity statistic, p < 0.0001) which could not be explained by evaluable study characteristics. When stratifying by military and civilian studies, the cumulative risk estimate was 2.0% (99% CI: 1.6-2.4) for military and 2.3% (99% CI: 2.1-2.5) for civilian studies. Conclusion. The overall cumulative incidence of 2.0% is what could be expected to occur among the local population in many developing-country settings, though TST conversion likely overestimates the risk of TB infection because of the low positive predictive value (PPV) of the TST in low-prevalence populations such as travelers. To maximize the PPV of a screening test for LTBI, a targeted testing strategy for long-term military and civilian travelers is recommended, based on exposures known to increase the risk of TB. Studies to better define higher risk groups, activities, and locations are needed. C1 [Freeman, Randall J.; Mancuso, James D.; Keep, Lisa W.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Freeman, Randall J.; Mancuso, James D.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. [Riddle, Mark S.] USN, Enter Dis Dept, Med Res Ctr, Silver Spring, MD USA. RP Freeman, RJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. EM Randall.Freeman@AMEDD.ARMY.MIL RI Riddle, Mark/A-8029-2011 NR 47 TC 18 Z9 18 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD JUL-AUG PY 2010 VL 17 IS 4 BP 233 EP 242 DI 10.1111/j.1708-8305.2010.00424.x PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 619SE UT WOS:000279449800004 PM 20636596 ER PT J AU Shah, PB Batyrev, I Derenge, MA Lee, U Nyguen, C Jones, KA AF Shah, P. B. Batyrev, I. Derenge, M. A. Lee, U. Nyguen, C. Jones, K. A. TI Schottky metal-GaN interface KOH pretreatment for improved device performance SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article; Proceedings Paper CT 56th Annual Meeting of the American-Vacuum-Society CY NOV 08-13, 2009 CL San Jose, CA SP Amer Vacuum Soc ID N-TYPE GAN; DEEP-LEVEL DEFECTS; BARRIER HEIGHT; SEMICONDUCTOR INTERFACES; SURFACE-TREATMENT; CONTACTS; STATES; FILMS; ANTISITE; DIODES AB The effect of KOH pretreatment for Au/Ni Schottky contacts to GaN is investigated using I-V and x-ray photoemission spectroscopy (XPS) analysis. The molten KOH pretreatment reduces the interface trap density from 1.0 X 10(12) to 2 X 10(11) cm(-2) eV(-1), improves the on-state performance, and increases the barrier height by 10%. XPS indicates that KOH improves the GaN Schottky diode performance by eliminating an oxide layer between the metal and the semiconductor, increasing the band bending through charge transfer, and improving the GaN stoichiometry at the surface. First principle simulations indicate that the nitrogen antisite and to a minor extent the gallium antisite are also possible constituents of this interfacial layer along with gallium and nitrogen vacancies. These antisite defects can be passivated by KOH. (C) 2010 American Vacuum Society. [DOI: 10.1116/1.3299253] C1 [Shah, P. B.; Batyrev, I.; Derenge, M. A.; Lee, U.; Nyguen, C.; Jones, K. A.] USA, Sensors & Electron Devices Directorate, Res Lab, RDRL SER E, Adelphi, MD 20783 USA. RP Shah, PB (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, RDRL SER E, Adelphi, MD 20783 USA. EM pankaj.shah@us.army.mil NR 33 TC 1 Z9 1 U1 1 U2 14 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD JUL-AUG PY 2010 VL 28 IS 4 BP 684 EP 688 DI 10.1116/1.3299253 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 633DM UT WOS:000280479700036 ER PT J AU Whitehouse, CA Keirstead, N Taylor, J Reinhardt, JL Beierschmitt, A AF Whitehouse, Chris A. Keirstead, Natalie Taylor, Justin Reinhardt, Jessica L. Beierschmitt, Amy TI Prevalence of Hypermucoid Klebsiella pneumoniae among Wild-caught and Captive Vervet Monkeys (Chlorocebus aethiops sabaeus) on the Island of St. Kitts SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE Abscess; African green monkeys; conservation medicine; ecohealth; enteric bacteria; nonhuman primate; zoonosis ID HYPERMUCOVISCOSITY PHENOTYPE; NONHUMAN-PRIMATES; LIVER-ABSCESS; EPIDEMIOLOGY AB Invasive, hypermucoid Klebsiella pneumoniae causes severe abscess formation in humans and in certain species of nonhuman primates We conducted a survey of captive and wild-caught African green monkeys, or velvets (Chlorocebus aethiops sabaeus), on the Canbbean island of St Kitts to assess then carriage rate of Klebsiella spp Forty percent of rectal swabs from captive monkeys were positive for K pneumoniae, and 20% of wild-caught annuals were positive Two. wild-caught monkeys (4%) were positive for K. oxytoca, and one monkey (2%) was found to be infected with a hypermucoid rmpA-positive K. pneumoniae strain Genotyping of this strain showed that it had an indistinguishable random amplified polymorphic DNA fingerprint to a strain that caused fatal abscessation in several African green monkeys in a research colony in the USA in 2005 This is the first report of hypermucoid K pneumoniae isolation from a wild population of nonhuman primates and represents a potential health risk to these animals, as well as to the humans who come in contact with them C1 [Whitehouse, Chris A.; Taylor, Justin; Reinhardt, Jessica L.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Keirstead, Natalie] Ross Univ, Sch Vet Med, Basseterre, St Kitts, W Ind Assoc St. [Beierschmitt, Amy] Behav Sci Fdn, Estridge Estate, St Kitts, W Ind Assoc St. RP Whitehouse, CA (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. FU Defense Threat Reduction Agency, Fort Belvoir, Virginia, USA; Internal kindling; Canadian Council for Animal Care FX We thank John Brake and Matt McMillan of Ross University School of Veterinary Medicine for production of the map This research was funded in part by the Defense Threat Reduction Agency, Fort Belvoir, Virginia, USA, and from Internal kindling from the Veterinary Medicine Division, USAMRIID The Behavioral Science Foundation is accredited by the Canadian Council for Animal Care, and all work with nonhuman primates was conducted as part of an Institutional Animal Care and Use Committee-approved protocol The opinions, interpretations, conclusions, and recommendation are those of the authors and arc not necessarily endorsed by the US Army NR 17 TC 8 Z9 8 U1 5 U2 8 PU WILDLIFE DISEASE ASSOC, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD JUL PY 2010 VL 46 IS 3 BP 971 EP 976 PG 6 WC Veterinary Sciences SC Veterinary Sciences GA 635XE UT WOS:000280690400035 PM 20688708 ER PT J AU Alavi, MR Ravizee, A Burgess, R Antonic, V Izadjoo, M Stojadinovic, A AF Alavi, M. R. Ravizee, A. Burgess, R. Antonic, V. Izadjoo, M. Stojadinovic, A. TI Resistance carrying plasmid in a traumatic wound SO JOURNAL OF WOUND CARE LA English DT Article DE antibiotic resistance; Enterobacter; plasmid; traumatic wound AB Objective: To isolate and identify antibiotic-resistant bacteria from the exudate of a complex wound and determine if antibiotic resistance genes are chromosomal or plasmid borne. Method: Antibiotic resistant bacteria from wound exudate of a single clinical sample were selected on agar media with ampicillin. A single colony was further screened for resistance to kanamycin by antibiotic-supplemented agar and to other antibiotics by an automated Phoenix instrument. Identification of the isolate was carried out by biochemical profiling and by 16S rDNA analysis. Results: Approximately 51% of total bacteria in the wound exudate with identical colony morphotype were resistant to 100 mu g/ml of ampicillin. A single colony from this population also demonstrated resistance to 50 mu g/ml of kanamycin on kanamycin-supplemented agar. Further antimicrobial sensitivity testing by the Phoenix instrument indicated resistance to inhibitory concentrations of amoxicillin-clavulanate, ampicillin-sulbactam, cefazolin, gentamicin, nitrofurantoin, tobramycin, and trimethoprim-sulfamethoxazole. Biochemical and 16S rDNA analysis identified this bacterial isolate as a member of genus Enterobacter. A plasmid preparation from this isolate successfully transferred ampicillin and kanamycin resistance to E. coli competent cells. E. coli transformants displayed two resistance phenotypes and the plasmids from these transformants displayed two different restriction type patterns, with one correlating to ampicillin and kanamycin resistance and the other only to ampicillin resistance. Conclusion: A multiple antibiotic-resistant Enterobacter spp. from the wound fluid of a clinical sample was found to carry an antibiotic-resistant plasmid in a closely related species E. coli. The presence of antibiotic resistance plasmid in Enterobacteria that are part of the normal microbial flora of the human gut and skin could lead to the spread of resistance phenotype and emergence of antibiotic resistant pathogens. This study suggests normal human microbial flora could be a potential reservoir for resistance genes. C1 [Alavi, M. R.; Ravizee, A.; Burgess, R.; Antonic, V.; Izadjoo, M.; Stojadinovic, A.] Armed Forces Inst Pathol, Wound Biol & Translat Res Div, Washington, DC 20306 USA. [Alavi, M. R.; Antonic, V.; Izadjoo, M.; Stojadinovic, A.] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC 20307 USA. [Stojadinovic, A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Alavi, MR (reprint author), Armed Forces Inst Pathol, Wound Biol & Translat Res Div, Washington, DC 20306 USA. EM alavim@afip.osd.mil NR 42 TC 0 Z9 0 U1 0 U2 1 PU MA HEALTHCARE LTD PI LONDON PA ST JUDES CHURCH, DULWICH ROAD, LONDON SE24 0PB, ENGLAND SN 0969-0700 J9 J WOUND CARE JI J. Wound Care PD JUL PY 2010 VL 19 IS 7 BP 306 EP 310 PG 5 WC Dermatology SC Dermatology GA V29CM UT WOS:000208726500006 PM 20616773 ER PT J AU Cox, ME Mathaudhu, SN Hartwig, KT Dunand, DC AF Cox, Marie E. Mathaudhu, Suveen N. Hartwig, K. Ted Dunand, David C. TI Amorphous Zr-Based Foams with Aligned, Elongated Pores SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT International Conference on Bulk Metallic Glasses held at the 2009 TMS Annual Meeting CY 2009 CL San Francisco, CA SP Minerals, Met & Mat Soc ID BULK METALLIC-GLASS; CHANNEL ANGULAR EXTRUSION; MATRIX COMPOSITES; MECHANICAL-PROPERTIES; POWDER; CONSOLIDATION; ALLOYS; DEFORMATION; PLASTICITY; DAMAGE AB Interpenetrating phase composites are created by warm equal channel angular extrusion (ECAE) of blended powders of amorphous Zr(58.5)Nb(2.8)Cu(15.6)Ni(12.8)Al(10.3) (Vit106a) and a crystalline ductile metal (Cu, Ni, or W). Subsequent dissolution of the continuous metallic phase results in amorphous Vit106a foams with similar to 40 pct aligned, elongated pores. The extent of Vit106a powder densification in the composites improves with the strength of the crystalline metallic powder, from low for Cu to high for W, with a concomitant improvement in foam compressive strength, ductility, and energy absorption. C1 [Cox, Marie E.; Dunand, David C.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. [Mathaudhu, Suveen N.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Hartwig, K. Ted] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RP Cox, ME (reprint author), Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA. EM dunand@northwestern.edu RI Dunand, David/B-7515-2009; Mathaudhu, Suveen/B-4192-2009; OI Dunand, David/0000-0001-5476-7379 NR 41 TC 1 Z9 1 U1 0 U2 16 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD JUL PY 2010 VL 41A IS 7 BP 1706 EP 1713 DI 10.1007/s11661-009-0039-3 PG 8 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 600BQ UT WOS:000277958700017 ER PT J AU Cordier, C Folco, L Taylor, S AF Cordier, C. Folco, L. Taylor, S. TI VESTOID ASTEROIDS AS A SOURCE FOR DIFFERENTIATED COSMIC SPHERULES SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 73rd Annual Meeting of the Meteoritical-Society CY JUL 26-30, 2010 CL New York, NY SP Meteorit Soc ID PARENT BODIES; MOON; MARS C1 [Cordier, C.; Folco, L.] Univ Siena, MNA, I-53100 Siena, Italy. [Taylor, S.] CRREL, Hanover, NH 03755 USA. EM cordier@unisi.it NR 6 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2010 VL 45 SU S BP A38 EP A38 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 633DC UT WOS:000280478700068 ER PT J AU Harvey, R Karner, J Taylor, S Gow, T Righter, K Calaway, M Harrington, R McBride, K Satterwhite, C Nishiizumi, K AF Harvey, R. Karner, J. Taylor, S. Gow, T. Righter, K. Calaway, M. Harrington, R. McBride, K. Satterwhite, C. Nishiizumi, K. TI PRELIMINARY OBSERVATIONS ON AN ANTARCTIC METEORITE FULLY ENCLOSED IN ICE SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 73rd Annual Meeting of the Meteoritical-Society CY JUL 26-30, 2010 CL New York, NY SP Meteorit Soc C1 [Harvey, R.; Karner, J.] Case Western Reserve Univ, Dept Geol Sci, Cleveland, OH 44106 USA. [Taylor, S.; Gow, T.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Righter, K.; Calaway, M.; Harrington, R.; McBride, K.; Satterwhite, C.] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA. [Nishiizumi, K.] Univ Calif Berkeley, Space Sci Lab, Berkeley, CA 94720 USA. EM rph@case.edu NR 4 TC 0 Z9 0 U1 0 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2010 VL 45 SU S BP A77 EP A77 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 633DC UT WOS:000280478700146 ER PT J AU Taylor, S Lindsay, FN Delaney, JS AF Taylor, S. Lindsay, F. N. Delaney, J. S. TI ALBITIC PLAGIOCLASE IN MICROMETEORITES FROM THE SOUTH POLE WATER WELL, ANTARCTICA SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 73rd Annual Meeting of the Meteoritical-Society CY JUL 26-30, 2010 CL New York, NY SP Meteorit Soc ID ACCRETION RATE; DUST C1 [Taylor, S.] CRREL, Hanover, NH 03755 USA. [Lindsay, F. N.] Rutgers State Univ, Dept Chem & Biol Chem, Piscataway, NJ 08854 USA. [Delaney, J. S.] Rutgers State Univ, Dept Geol Sci, Piscataway, NJ 08854 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD JUL PY 2010 VL 45 SU S BP A200 EP A200 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 633DC UT WOS:000280478700389 ER PT J AU Buckenmaier, CC Griffith, S AF Buckenmaier, Chester C., III Griffith, Scott TI Military Pain Management in 21st Century War SO MILITARY MEDICINE LA English DT Article ID POSTOPERATIVE OPIOID ANALGESIA; MULTIMODAL ANALGESIA; SURGERY; RELIEF; CARE AB Morphine and other opioid drugs have played a major role in austere environment pain management since the Civil War, particularly in the military. While the pre-eminence and success of such medications is without question, their use is accompanied by significant side effects that are undesirable in the most advanced medical settings, and are potentially devastating in the field environment. Recently, there have been significant improvements in pain care for America's wounded service members, along with a shift in how many care providers view pain management. An increasing number of healthcare providers are seeing pain not merely as a symptom, but as a disease process. In addition to dramatically improving care for wounded service members, the evolution in the military's approach to pain is enhancing care for civilians. C1 [Buckenmaier, Chester C., III; Griffith, Scott] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Buckenmaier, CC (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. OI Buckenmaier III, Chester/0000-0003-3623-5525 FU John P. Murtha Neuroscience and Pain Institute FX This work was supported by John P. Murtha Neuroscience and Pain Institute. NR 23 TC 4 Z9 4 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 SU S BP 7 EP 12 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 624EP UT WOS:000279799400003 PM 23634472 ER PT J AU Fitzpatrick, KF Pasquina, PF AF Fitzpatrick, Kevin F. Pasquina, Paul F. TI Overview of the Rehabilitation of the Combat Casualty SO MILITARY MEDICINE LA English DT Article ID CARE AB Current military conflicts, including Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), have presented unique challenges in the medical, surgical, and rehabilitation care of service members injured in a combat setting. Although modern body armor and advances in medical and surgical capabilities have resulted in a significant improvement in survival rates from severe injuries, rehabilitation strategies must adapt to keep pace with these advances. Rehabilitation of the combat casualty requires the integration of multiple professional disciplines to optimally address the complex medical and surgical conditions, challenging geographic limitations and unique psychosocial factors to meet the expectations of patients, families, government, and society. C1 [Fitzpatrick, Kevin F.; Pasquina, Paul F.] Walter Reed Army Med Ctr, Integrated Dept Orthoped & Rehabil, Washington, DC 20307 USA. [Fitzpatrick, Kevin F.; Pasquina, Paul F.] Natl Naval Med Ctr, Bethesda, MD 20889 USA. RP Fitzpatrick, KF (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthoped & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 11 TC 3 Z9 5 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 SU S BP 13 EP 17 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624EP UT WOS:000279799400004 PM 23634473 ER PT J AU Stojadinovic, A Elster, E Potter, BK Davis, TA Tadaki, DK Brown, TS Ahlers, S Attinger, CE Andersen, RC Burris, D Centeno, J Champion, H Crumbley, DR Denobile, J Duga, M Dunne, JR Eberhardt, J Ennis, WJ Forsberg, JA Hawksworth, J Helling, TS Lazarus, GS Milner, SM Mullick, FG Owner, CR Pasquina, PF Patel, CR Peoples, GE Nissan, A Ring, M Sandberg, GD Schaden, W Schultz, GS Scofield, T Shawen, SB Sheppard, FR Stannard, JP Weina, PJ Zenilman, JM AF Stojadinovic, Alexander Elster, Eric Potter, Benjamin K. Davis, Thomas A. Tadaki, Doug K. Brown, Trevor S. Ahlers, Stephen Attinger, Christopher E. Andersen, Romney C. Burris, David Centeno, Jose Champion, Hunter Crumbley, David R. Denobile, John Duga, Michael Dunne, James R. Eberhardt, John Ennis, William J. Forsberg, Jonathan A. Hawksworth, Jason Helling, Thomas S. Lazarus, Gerald S. Milner, Stephen M. Mullick, Florabel G. Owner, Christopher R. Pasquina, Paul F. Patel, Chirag R. Peoples, George E. Nissan, Aviram Ring, Michael Sandberg, Glenn D. Schaden, Wolfgang Schultz, Gregory S. Scofield, Tom Shawen, Scott B. Sheppard, Forest R. Stannard, James P. Weina, Peter J. Zenilman, Jonathan M. TI Combat Wound Initiative Program SO MILITARY MEDICINE LA English DT Article ID EXTRACORPOREAL SHOCK-WAVE; THERAPY AB The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Elster, Eric; Davis, Thomas A.; Tadaki, Doug K.; Brown, Trevor S.; Ahlers, Stephen] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Potter, Benjamin K.] Walter Reed Army Med Ctr, Mil Adv Training Ctr, Washington, DC 20307 USA. [Attinger, Christopher E.] Georgetown Univ Hosp, PHC, Washington, DC 20007 USA. [Andersen, Romney C.; Pasquina, Paul F.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Burris, David] Uniformed Serv Univ Hlth Sci, Norman M Rich Dept Surg, Amer Coll Surg, Comm Trauma, Bethesda, MD 20814 USA. [Centeno, Jose] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Champion, Hunter] Johns Hopkins Univ Hosp, Baltimore, MD 21205 USA. [Denobile, John] Natl Naval Med Ctr, Dept Surg, Bethesda, MD 20889 USA. [Eberhardt, John] DecisionQ Corp, Washington, DC 20008 USA. [Ennis, William J.] Univ Illinois, Chicago, IL 60612 USA. [Helling, Thomas S.] Temple Univ, Conemaugh Mem Med Ctr, Dept Surg, Johnstown, PA 15905 USA. [Lazarus, Gerald S.; Milner, Stephen M.] Johns Hopkins Bayview Med Ctr, Baltimore, MD 21224 USA. [Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Nissan, Aviram] Hadassah Univ Hosp, Dept Surg, IL-91240 Jerusalem, Israel. [Ring, Michael] NIDDK, NIH, Transplant Sect, Ctr Clin, Bethesda, MD 20892 USA. [Schaden, Wolfgang] Trauma Ctr Meidling, A-1030 Vienna, Austria. [Schultz, Gregory S.] Univ Florida, Inst Wound Res, Dept Obstet & Gynecol, Gainesville, FL 32610 USA. [Scofield, Tom] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20852 USA. [Shawen, Scott B.] Walter Reed Army Med Ctr, Orthoped Surg Serv, Washington, DC 20307 USA. [Stannard, James P.] Univ Alabama, Dept Orthoped Trauma, Birmingham, AL 35294 USA. [Weina, Peter J.] Walter Reed Army Inst Res, Div Expt Therapeut, Washington, DC 20307 USA. [Zenilman, Jonathan M.] Johns Hopkins Bayview Med Ctr, Div Infect Dis, Baltimore, MD 21224 USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. RI Patel, Chirag/J-7030-2013; Brown, Trevor/K-4703-2012 OI Brown, Trevor/0000-0001-7042-785X FU United States Army Medical Research Acquisition Activity, Fort Detrick, Maryland [W81XWH-08-2-0700]; U.S. Navy Bureau of Medicine and Surgery [PE 0604771N]; Office of Naval Research [BUMED/ML 601153N.04508.5180.A0801] FX The Combat Wound Initiative program received financial support from U.S. Army Medical Research and Materiel Command through the United States Army Medical Research Acquisition Activity, Fort Detrick, Maryland, grant number W81XWH-08-2-0700, effective September 18,2008. This effort was also supported in part by the U.S. Navy Bureau of Medicine and Surgery under the Medical Development Program (PE 0604771N) and the Office of Naval Research (BUMED/ML 601153N.04508.5180.A0801). NR 11 TC 1 Z9 1 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 SU S BP 18 EP 24 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 624EP UT WOS:000279799400005 PM 23634474 ER PT J AU Jaffee, M Martin, EM AF Jaffee, Michael Martin, Elisabeth Moy TI Defense and Veterans Brain Injury Center: Program Overview and Research Initiatives SO MILITARY MEDICINE LA English DT Article ID HEAD-INJURY; REHABILITATION; TRIAL AB For more than 16 years, the Defense and Veterans Brain Injury Center (at one time known as the Defense and Veterans Head Injury Program) has served to develop and disseminate clinical guidelines and undertake innovative clinical research initiatives and educational programs to serve active duty personnel, their dependents, and veterans with traumatic brain injury (TBI). Through educational initiatives and collaboration with civilian institutions, the center is ensuring that critical discoveries surrounding TBI prevention, screening, and treatment are made available to preserve and improve the health of those within and outside the military health system. C1 [Jaffee, Michael; Martin, Elisabeth Moy] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20012 USA. RP Jaffee, M (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, POB 59181, Washington, DC 20012 USA. NR 13 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 SU S BP 37 EP 41 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624EP UT WOS:000279799400008 PM 23634477 ER PT J AU Shriver, CD AF Shriver, Craig D. TI 21st Century Paradigm of Tissue Banking: The Clinical Breast Care Project SO MILITARY MEDICINE LA English DT Article AB The Clinical Breast Care Project (CBCP) is a congressionally mandated program that began in the year 2000. The military-civilian collaboration was founded on five pillars: (1) center of excellence in clinical care, (2) risk reduction for women at risk for developing breast cancer, (3) tissue banking to develop and maintain the world's finest repository of human biospecimens of breast diseases, (4) targeted research into the molecular signatures of breast diseases and cancer, and (5) biomedical informatics core to support the data warehouse needs of the project. Now in its eighth year of operation, these efforts have resulted in more than 300 peer-reviewed scientific publications and dozens of collaborations with world leaders in cancer research. In this short time, CBCP has created what is believed to be the world's largest breast tissue biorepository. C1 Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Shriver, CD (reprint author), Walter Reed Army Med Ctr, Clin Breast Care Project, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 SU S BP 49 EP 53 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624EP UT WOS:000279799400011 PM 23634480 ER PT J AU Clifton, T Pappas, JA Pavlik, M Papay, D Holmes, JP Ponniah, S Peoples, GE AF Clifton, Travis Pappas, Jennifer A. Pavlik, Maureen Papay, Diane Holmes, Jarrod P. Ponniah, Sathibalan Peoples, George E. TI Cancer Vaccine Development Program Collaborations SO MILITARY MEDICINE LA English DT Article ID GROUP-STUDY I-01; HER2/NEU E75 VACCINE; I CLINICAL-TRIAL; GM-CSF VACCINE; PEPTIDE E75; T-CELLS; BREAST; RECURRENCE; PREVENTION AB Immunotherapy for cancer, which uses the body's immune system to fight the disease, is an increasingly active area of research. Successful therapies such as trastuzamab (Herceptin) for breast cancer and cytokine therapy for renal cell carcinoma and melanoma have validated the field as a viable area of investigation. However, the goal of developing an effective cancer vaccine has not yet been achieved. The military's Cancer Vaccine Development Program (CVDP) is collaborating with other military programs, along with civilian institutions, to advance scientific research surrounding cancer vaccines. C1 [Clifton, Travis; Peoples, George E.] Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, Ft Sam Houston, TX 78234 USA. [Pappas, Jennifer A.; Pavlik, Maureen; Papay, Diane; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD 20814 USA. [Holmes, Jarrod P.] USN, San Diego Med Ctr, Dept Hematol Oncol, San Diego, CA 92152 USA. RP Clifton, T (reprint author), Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. FU United States Military Cancer Institute; Department of Surgery; Uniformed Services University of the Health Sciences; Department of Clinical Investigation; Walter Reed Army Medical Center FX The authors acknowledge the contributions of the principal investigators and study coordinators at the individual military and civilian study sites, as well as the industry collaborators who provide funding for the clinical trials. The authors also gratefully acknowledge the contributions of Dr. Sathibalan Ponniah, Kathy Ciano, Yusuf Jama, Mohamed Mursal, and Athina Zacharia. This work was supported by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, and the Department of Clinical Investigation, Walter Reed Army Medical Center. NR 17 TC 0 Z9 0 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 SU S BP 54 EP 56 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 624EP UT WOS:000279799400012 PM 23634481 ER PT J AU Meynard, JB Chaudet, H Varcol, C Decker, E Andresen, S Holterm, HU Zuendorf, A Kocik, J Bolton, JP Maza, JP Boutin, JP Migliani, R Deparis, X Texier, G AF Meynard, Jean-Baptiste Chaudet, Herve Varcol, Christian Decker, Elisabeth Andresen, Sven Holterm, Hans-Ulrich Zuendorf, Andreas Kocik, Janusz Bolton, John Philip Maza, John P. Boutin, Jean-Paul Migliani, Rene Deparis, Xavier Texier, Gaetan TI Evaluation of the NATO Disease Surveillance System by Its Users in Kosovo in 2008 SO MILITARY MEDICINE LA English DT Editorial Material C1 [Meynard, Jean-Baptiste; Migliani, Rene] Ecole Val Grace, F-75230 Paris, France. [Chaudet, Herve; Zuendorf, Andreas; Boutin, Jean-Paul; Deparis, Xavier; Texier, Gaetan] Serv Sante Armees, Inst Trop Med, F-13998 Marseille, France. [Varcol, Christian] NATO Consultat Command & Control Agcy, NL-2597 AK The Hague, Netherlands. [Decker, Elisabeth; Andresen, Sven] KFOR Headquarters, K-10020 Pristina, Kosovo, Serbia. [Holterm, Hans-Ulrich] Saniaetskommando I Prevent Med Dept, D-24106 Kiel, Germany. [Kocik, Janusz] Mil Inst Hyg & Epidemiol, PL-01163 Warsaw, Poland. [Bolton, John Philip] UK Minist Def, Def Med Serv Dept, London SW1A 2HB, England. [Maza, John P.] US Army Ctr Hlth Promot & Prevent Med Europe, D-66877 Ramstein, Germany. RP Meynard, JB (reprint author), Ecole Val Grace, 1 Pl Alphonse Laveran, F-75230 Paris, France. NR 0 TC 2 Z9 3 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 BP 466 EP 468 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 624EN UT WOS:000279799200003 PM 20684448 ER PT J AU Belmont, PJ Goodman, GP Waterman, B DeZee, K Burks, R Owens, BD AF Belmont, Philip J., Jr. Goodman, Gens P. Waterman, Brian DeZee, Kent Burks, Rob Owens, Brett D. TI Disease and Nonbattle Injuries Sustained by a US Army Brigade Combat Team During Operation Iraqi Freedom SO MILITARY MEDICINE LA English DT Article ID CRUCIATE LIGAMENT INJURY; UNITED-STATES MILITARY; PERSIAN-GULF-WAR; SHOULDER DISLOCATION; ANKLE SPRAINS; SURGICAL-TEAM; EPIDEMIOLOGY; BATTLE; CASUALTY; AFGHANISTAN AB Background: A longitudinal cohort analysis of disease nonbattle injuries (DNBI) sustained by a large combat-deployed maneuver unit has not been performed. Methods: A descriptive analysis was undertaken to evaluate for DNBI casualty care statistics incurred by a U.S. Army Brigade Combat Team (BCT) during a counterinsurgency campaign of Operation Iraqi Freedom. Results: Of the 4,122 soldiers deployed, there were 1,324 DNBI with 5 (0.38%) deaths, 208 (15.7%) medical evacuations (MEDEVAC), and 1,111 (83.9%) returned to duty. The DNBI casualty rate for the BCT was 257.0/1,000 soldier combat-years. Females, compared with males, had a significantly increased incidence rate ratio for becoming a DNBI casualty 1.67 (95% CI 1.37, 2.04). Of 47 female soldiers receiving MEDEVAC 35 (74%) were for pregnancy-related issues. Musculoskeletal injuries (50.4%) and psychiatric disorders (23.3%) were the most common body systems involved with DNBI casualties. Among the BCT cohort the psychiatric DNBI casualty rate and suicide rate were 59.8 and 0.58 per 1,000 soldier combat-years. The BCT cohort incidence rates for common musculoskeletal injuries per 1,000 combat years were as follows: ankle sprain 15.3, anterior cruciate ligament rupture 3.3 and shoulder dislocation 1.2. Conclusions: Musculoskeletal injuries and psychiatric disorders accounted for 74% of the total DNBI casualties, and 43% of the DNBI casualties requiring subsequent MEDEVAC. The BCT cohort had a suicide rate nearly four times greater than previously reported, and selected musculoskeletal injury incidence rates were fivefold greater than the general population. C1 [Belmont, Philip J., Jr.; Goodman, Gens P.; Waterman, Brian; DeZee, Kent] William Beaumont Army Med Ctr, El Paso, TX 79920 USA. [Burks, Rob] USN, Postgrad Sch, Grad Sch Operat & Informat Sci, Monterey, CA 93943 USA. [Owens, Brett D.] US Mil Acad, Keller Army Community Hosp, West Point, NY 10996 USA. RP Belmont, PJ (reprint author), William Beaumont Army Med Ctr, El Paso, TX 79920 USA. RI Burks, Robert/J-2481-2015; OI Burks, Robert/0000-0001-6443-6653; Belmont, Philip/0000-0003-2618-199X NR 40 TC 36 Z9 39 U1 1 U2 4 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 BP 469 EP 476 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 624EN UT WOS:000279799200004 PM 20684449 ER PT J AU Coldren, RL Kelly, MP Parish, RV Dretsch, M Russell, ML AF Coldren, Rodney L. Kelly, Mark P. Parish, Robert V. Dretsch, Michael Russell, Michael L. TI Evaluation of the Military Acute Concussion Evaluation for Use in Combat Operations More Than 12 Hours After Injury SO MILITARY MEDICINE LA English DT Article ID SPORT-RELATED CONCUSSION; FOOTBALL PLAYERS; STANDARDIZED ASSESSMENT; RECOVERY AB The diagnosis and management of concussion can be difficult in a combat environment, especially in the absence of loss of consciousness or post-traumatic amnesia. As no validated test exists to diagnose or grade neurocognitive impairment from a concussion, the military currently employs the Military Acute Concussion Evaluation (MACE) in Iraq. This is a two-part test, which incorporates the standardized assessment of concussion (SAC) as its objective score, although it has not been shown to be valid unless administered shortly after injury. A research team deployed to Iraq between January and April 2009 to examine the validity of several tests of neurocognitive function following a concussion, including the MACE. When administered more than 12 hours after the concussive injury, the MACE lacked sufficient sensitivity and specificity to be clinically useful. C1 [Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Kelly, Mark P.; Parish, Robert V.] Walter Reed Army Med Ctr, Dept Psychol, Washington, DC 20003 USA. [Dretsch, Michael] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Russell, Michael L.] Lincoln Ctr, San Antonio, TX 78230 USA. RP Coldren, RL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 16 TC 38 Z9 38 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 BP 477 EP 481 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624EN UT WOS:000279799200005 PM 20684450 ER PT J AU Killgore, WDS Kelley, A Balkin, TJ AF Killgore, William D. S. Kelley, Amanda Balkin, Thomas J. TI So You Think You're Bulletproof: Development and Validation of the Invincibility Belief Index (IBI) SO MILITARY MEDICINE LA English DT Article ID MENTAL-HEALTH PROBLEMS; POSTTRAUMATIC-STRESS-DISORDER; RISK-PROPENSITY; MILITARY PERSONNEL; US MILITARY; VETERANS; DEPLOYMENT; SOLDIERS; VALIDITY; IRAQ AB Risk-taking propensity can be influenced by sensation-seeking traits and self-perceived invincibility. We hypothesized that the latter factor may reflect a stable trait that endures across situations and may influence risk-taking behavior. We developed and validated a 20-item scale, the Invincibility Belief Index (IBI) to measure this construct. The IBI demonstrated good internal consistency and excellent test-retest reliability in the development sample (n = 100) and sustained similar levels of reliability in a cross-validation sample (n = 74). Principal components analysis yielded three orthogonal factors measuring self-perceived impunity (immunity from consequences), boldness/audacity (self-assuredness and competitiveness), and adroitness (mental agility and survival skill). In the prediction of risk taking, IBI scores contributed additional unique variance beyond sensation-seeking scores alone. IBI scores demonstrated convergent and discriminant validity with concurrently administered measures. These preliminary results support the reliability and validity of the IBI as a brief measure of self-perceived vulnerability invincibility in the face of adversity. C1 [Killgore, William D. S.] Harvard Univ, Sch Med, Brain Imaging Ctr, McLean Hosp, Belmont, MA 02478 USA. [Kelley, Amanda] USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. [Killgore, William D. S.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), Harvard Univ, Sch Med, Brain Imaging Ctr, McLean Hosp, 115 Mill St, Belmont, MA 02478 USA. OI Killgore, William/0000-0002-5328-0208 FU U.S. Army Medical Research and Materiel Command Military Operational Medicine Research Program (MOMRP) FX This work was supported by the U.S. Army Medical Research and Materiel Command Military Operational Medicine Research Program (MOMRP). NR 33 TC 7 Z9 7 U1 0 U2 5 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 BP 499 EP 508 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 624EN UT WOS:000279799200009 PM 20684454 ER PT J AU Hulten, E Carbonaro, S Gibbs, B Cheezum, M Feuerstein, I Simpson, D Taylor, AJ Villines, TC AF Hulten, Eddie Carbonaro, Salvatore Gibbs, Barnett Cheezum, Michael Feuerstein, Irwin Simpson, Daniel Taylor, Allen J. Villines, Todd C. TI Decreasing Outpatient Cardiac Catheterization Rates Associated With Cardiology Clinic Volume but Not With Increasing Cardiac Computed Tomography Utilization SO MILITARY MEDICINE LA English DT Article ID ANGIOGRAPHY; DISEASE AB Cardiac computed tomographic angiography (CTA) is an accurate noninvasive test for diagnosing coronary artery disease (CAD). To investigate whether increasing use of CTA is correlated with left heart catheterization (LHC) rates, we performed a retrospective review of existing outpatient and inpatient catheterization lab and CTA electronic medical records from July 1, 2004 to June 30, 2008. Comparing the previous 2 years (July 2004-June 2006) to the 2 years after addition of CTA (July 2006 June 2008), monthly LHC rates decreased 20 +/- 6% (p = 0.08) and percutaneous coronary intervention (PCI) rates decreased 47 +/- 6% (p < 0.001). Cardiology clinic volume declined 34%. CTA rates increased 64 +/- 7% (p <0.001). Radionuclide myocardial perfusion scan (MPS) usage remained stable. Despite increased utilization over the past 2 years, CTA was not correlated with significantly reduced LHC rates. The decline of outpatient LHC rates at our institution over 4 years is mainly influenced by decreasing outpatient Cardiology clinic volume. C1 [Hulten, Eddie; Carbonaro, Salvatore; Gibbs, Barnett; Simpson, Daniel; Taylor, Allen J.; Villines, Todd C.] Walter Reed Army Med Ctr, Dept Internal Med, Serv Cardiol, Washington, DC 20307 USA. [Feuerstein, Irwin] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Taylor, Allen J.] Washington Hosp Ctr, Div Cardiol, Washington, DC 20010 USA. RP Hulten, E (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, Serv Cardiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. OI Hulten, Edward/0000-0001-9281-0032 NR 6 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 BP 529 EP 533 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624EN UT WOS:000279799200014 PM 20684459 ER PT J AU Kent, JB Oh, RC AF Kent, Jeremy B. Oh, Robert C. TI Complementary and Alternative Medicine Use Among Military Family Medicine Patients in Hawaii SO MILITARY MEDICINE LA English DT Article ID UNITED-STATES AB Complementary and alternative medicine (CAM) is a growing component of medicine within the U.S. civilian and military populations. Tripler Army Medical Center (TAMC) Family Medicine Clinic represents an overseas medical facility stationed among a diverse ethnic population. The impact that local cultures have on CAM utilization in the military population in overseas medical facilities is unknown. Methods: Cross-sectional survey. The authors surveyed all volunteer soldiers, family members, and retirees 18 years old or greater enrolled at TAMC Family Medicine Clinic with appointments between September 1 and September 25, 2008. Results: 503 volunteers were surveyed with a response rate of 73% (n = 369). A total of 50.7% reported using at least one CAM therapy within the last year. CAM use was significantly higher among women, Caucasians, and a college level education or greater. Conclusion: Prevalence of CAM use is higher within a military family medicine clinic in Hawaii than the prevalence among mainland civilian or other military populations. C1 [Kent, Jeremy B.; Oh, Robert C.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA. RP Kent, JB (reprint author), Tripler Army Med Ctr, Dept Family Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. FU Tripler Army Medical Center Family Medicine Department FX This work was supported by Tripler Army Medical Center Family Medicine Department. NR 24 TC 4 Z9 4 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2010 VL 175 IS 7 BP 534 EP 538 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 624EN UT WOS:000279799200015 PM 20684460 ER PT J AU Jirage, D Chen, YQ Caridha, D O'Neil, MT Eyase, F Witola, WH Ben Mamoun, C Waters, NC AF Jirage, Dayadevi Chen, Yueqin Caridha, Diana O'Neil, Michael T. Eyase, Fredrick Witola, William H. Ben Mamoun, Choukri Waters, Norman C. TI The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE Malaria; CDK; Pfmrk; DNA replication; Cell cycle; Plasmodium ID PARASITE PLASMODIUM-FALCIPARUM; CYCLIN-DEPENDENT KINASE; ACTIVATING KINASE; CELL-CYCLE; FUNCTIONAL-CHARACTERIZATION; SUBSTRATE-SPECIFICITY; CDC2-RELATED KINASE; TERMINAL DOMAIN; MCM COMPLEX; MAT1 AB Cyclin-dependent kinases (CDKs) have an established role in metazoans and yeast in DNA replication, transcription and cell cycle regulation. Several CDKs and their effectors have been identified in the malaria parasite Plasmodium falciparum and their biological functions are beginning to be investigated. Here we report results from the functional characterization of Pfmrk and its effector PfMAT1. We validated the interactions between Pfmrk and PfMAT1 and pinpointed their intracellular location. Co-immunoprecipitation studies demonstrated physical interaction between the two proteins and identified the C-terminal domain of PfMAT1 as the Pfmrk activator domain. Immunofluorescence analyses using GFP and RFP-tagged versions of Pfmrk and PfMAT1, respectively, demonstrated the co-localization of these two proteins to the parasite nucleus. Bacterial two-hybrid screen of a P. falciparum cDNA library using Pfmrk as the bait identified two plasmodial DNA replication proteins, PfRFC-5 and PfMCM6, as interactors with Pfmrk. We demonstrate that that these two proteins are substrates of Pfmrk-mediated phosphorylation and that PfMAT1 confers substrate specificity to the Pfmrk kinase complex. Collectively, these data suggest a role for Pfmrk in the nucleus of the parasite presumably in regulation of the DNA replication machinery. Published by Elsevier B.V. C1 [Waters, Norman C.] Australian Army Malaria Inst, WRAIR Lab, Enoggera, Qld 4051, Australia. [Jirage, Dayadevi; Chen, Yueqin; Caridha, Diana; O'Neil, Michael T.; Waters, Norman C.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Eyase, Fredrick] US Army Med Res Unit Kenya, Walter Reed Project, Apo 098314109, AE, Kenya. [Witola, William H.] Univ Chicago, Med Ctr, Dept Ophthalmol & Visual Sci, Chicago, IL 60637 USA. [Ben Mamoun, Choukri] Yale Univ, Sch Med, Infect Dis Sect, New Haven, CT 06520 USA. RP Waters, NC (reprint author), Australian Army Malaria Inst, WRAIR Lab, Enoggera, Qld 4051, Australia. EM norman.waters@us.army.mil FU National Research Council FX We are grateful for the contribution of the P. falciparum database PlasmoDB and thank its organizers for maintaining this excellent resource. The authors thank Susan Leed for editing the manuscript and David Miles for help with preparation of figures using Adobe Photoshop. D. Jirage received support from the National Research Council during the course of this work. NR 60 TC 14 Z9 14 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 EI 1872-9428 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD JUL PY 2010 VL 172 IS 1 BP 9 EP 18 DI 10.1016/j.molbiopara.2010.03.009 PG 10 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA 604FN UT WOS:000278262800002 PM 20332005 ER PT J AU Mulvaney, SW McLean, B de Leeuw, J AF Mulvaney, Sean W. McLean, Brian de Leeuw, Jason TI The Use of Stellate Ganglion Block in the Treatment of Panic/Anxiety Symptoms with Combat-Related Post-Traumatic Stress Disorder; Preliminary Results of Long-Term Follow-Up: A Case Series SO PAIN PRACTICE LA English DT Article DE post-traumatic stress disorder; stellate ganglion block; anxiety; sympathetic ID REGIONAL PAIN SYNDROME; NERVOUS-SYSTEM; SYMPATHETIC BLOCKADE; PTSD; CHECKLIST; NGF; NOREPINEPHRINE; VULNERABILITY; DEATH; CARE AB Objective: Report the successful use of stellate ganglion blocks (SGBs) in two patients experiencing symptoms of post-traumatic stress disorder (PTSD). Background: Successful treatment of PTSD with SGB has been reported previously. A similar protocol was employed at Walter Reed Army Medical Center to treat two soldiers with chronic, combat-related PTSD. Methods: Both patients received a SGB on the right side at C6 level. The patients' PTSD symptoms were evaluated using the Post-traumatic Stress Disorder Checklist (PCL). The PCL was administered the day prior to treatment, to establish a baseline, and the day after treatment. The PCL was also utilized during follow-up visits to quantify the patient's symptomotology. The SGB was administered by an anesthesiologist and the psychometric tests administered by a psychologist. Results: Both patients experienced immediate, significant and durable relief as measured by the PCL (score minimum 17, maximum 85). In both instances, the pre-treatment score suggested a PTSD diagnosis whereas the post-treatment scores did not. One patient requested repeat treatment after 3 months, and the post-treatment score remained below the PTSD cutoff after 7 additional months of follow-up. Both patients discontinued all antidepressant and antipsychotic medications while maintaining their improved PCL score. Conclusion: Selective blockade of the right stellate ganglion at C6 level is a safe and minimally invasive procedure that may provide durable relief from PTSD symptoms, allowing the safe discontinuation of psychiatric medications. C1 [Mulvaney, Sean W.] Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, Bethesda, MD 20814 USA. [McLean, Brian] Tripler Army Med Ctr, Dept Intervent Pain Management & Anesthesia, Honolulu, HI 96859 USA. [de Leeuw, Jason] Kimbrough Ambulatory Care Ctr, Ft George G Meade, MD USA. RP Mulvaney, SW (reprint author), Uniformed Serv Univ Hlth Sci, Consortium Hlth & Mil Performance, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM seanmulvaney@hotmail.com NR 29 TC 15 Z9 17 U1 0 U2 1 PU WILEY PERIODICALS, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN STREET, MALDEN, MA 02148-529 USA SN 1530-7085 J9 PAIN PRACT JI Pain Pract. PD JUL-AUG PY 2010 VL 10 IS 4 BP 359 EP 365 DI 10.1111/j.1533-2500.2010.00373.x PG 7 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA 840TD UT WOS:000296463300011 PM 20412504 ER PT J AU Eide, M Gorman, G Hisle-Gorman, E AF Eide, Matilda Gorman, Gregory Hisle-Gorman, Elizabeth TI Effects of Parental Military Deployment on Pediatric Outpatient and Well-Child Visit Rates SO PEDIATRICS LA English DT Article DE military health system; well-child care; deployment ID INDUCED SEPARATION; CARE USE; BEHAVIOR; FAMILIES; WARTIME; IMPACT AB OBJECTIVE: The objective of this study was to determine whether parental deployment affected the rates at which children of military parents accessed health care within the military health system. METHODS: We linked outpatient health care claims data for military service members' children <2 years of age from fiscal year 2007 to the parental deployment history during the same period. Incidence rate ratios (IRRs) for all visits and well-child visits were determined according to parental deployment status. RESULTS: A total of 169 986 children were identified, with 1 772 703 outpatient visits. Of those children, 32% had a parent deployed during the study period. Well-child visits constituted 27% of all outpatient visits. The unadjusted visit rates for all visits and well-child visits were 10.4 and 2.8 visits per year, respectively. Children of single parents had decreased rates of outpatient visits (IRR: 0.84 [95% confidence interval [CI]: 0.80-0.89]; P < .001) and well-child visits (IRR: 0.88 [95% CI: 0.84-0.93]; P < .001) during deployment. Children of married parents, however, had increased rates of both outpatient visits (IRR: 1.08 [95% CI: 1.03-1.09]; P < .001) and well-child visits (IRR: 1.08 [95% CI: 1.07-1.09]; P < .001) during deployment. There was interaction between parental marital status and deployment, which was most significant among parents <24 years of age and consistently decreased with increasing parental age. CONCLUSIONS: Children of young, single, military parents are seen less frequently for acute and well-child care when their parent is deployed, whereas children of married parents are seen more frequently in the military health system. Pediatrics 2010;126:22-27 C1 [Eide, Matilda; Gorman, Gregory] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Gorman, Gregory] Walter Reed Army Med Ctr, Sect Pediat Nephrol, Washington, DC 20307 USA. Natl Naval Med Ctr, Washington, DC USA. [Hisle-Gorman, Elizabeth] Univ Maryland, Sch Social Work, Baltimore, MD 21201 USA. RP Eide, M (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mbeadling@usuhs.mil NR 13 TC 8 Z9 8 U1 1 U2 3 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 EI 1098-4275 J9 PEDIATRICS JI Pediatrics PD JUL PY 2010 VL 126 IS 1 BP 22 EP 27 DI 10.1542/peds.2009-2704 PG 6 WC Pediatrics SC Pediatrics GA 619LF UT WOS:000279431000004 PM 20530074 ER PT J AU Ben-David, A Sagripanti, JL AF Ben-David, Avishai Sagripanti, Jose-Luis TI A Model for Inactivation of Microbes Suspended in the Atmosphere by Solar Ultraviolet Radiation SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Article ID REMOTE-SENSING APPLICATIONS; SPECTRAL ACTINIC FLUX; INFRARED WAVELENGTHS; BIOLOGICAL AEROSOLS; GLOBAL RADIATION; IRRADIANCE; PHOTODISSOCIATION; SENSITIVITY; VIRUSES; VAPORS AB Solar ultraviolet (UV) light within 280-320 nm (UVB) is the primary cause for virus inactivation in the atmosphere. Only the effect of the direct component has been previously evaluated. We developed a simple regression model to estimate the inactivation of a virus due to direct (unscattered), diffuse (scattered) and total (direct + diffuse) components of solar UV (daily integrated irradiances). The model predicts the maximum number of radiation-days a virus will survive at a given altitude above the ground in rural and urban environments under clear skies. We explored the effect of several environmental variables: visibility, altitude and ground reflectivity. We found that the effect of diffuse radiation on virus inactivation was larger than the direct component. The diffuse irradiance increased with ground albedo (mainly due to reflection of the direct attenuated solar off the ground) and decreased with increased visibility (proportional to aerosol loading in the atmosphere). The diffuse component increased with altitude, but the ratio of diffuse to the total decreased with increased altitude, highlighting the importance of the diffuse component of UV near the ground. Our model may help public health studies in predicting and understanding the effect of environmental parameters on the survival of germs. C1 [Ben-David, Avishai; Sagripanti, Jose-Luis] USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD USA. RP Ben-David, A (reprint author), USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD USA. EM avishai.bendavid@us.army.mil FU Edgewood Chemical Biological Center FX We are grateful to discussions, insight and advice regarding the use and interpretation of MODTRAN generously provided by Dr. Lex Berk (Spectral Sciences Incorporated, Burlington, MA), Dr. Gail Anderson (Air Force Research Laboratory, Hanscom AFB, MA) and Dr. Eric Shettle (Naval Research Laboratory, Washington, DC). We are especially thankful to Dr. Charlie Davidson (Science and Technology Corporation) for his mathematical insight and his help with regard to writing computer programs during this project. This work was funded by the In-House Laboratory Independent Research grant from Edgewood Chemical Biological Center. NR 51 TC 3 Z9 3 U1 1 U2 5 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD JUL-AUG PY 2010 VL 86 IS 4 BP 895 EP 908 DI 10.1111/j.1751-1097.2010.00738.x PG 14 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 622NM UT WOS:000279670500024 PM 20492569 ER PT J AU Smith, ER Gruber, JB Wellenius, P Muth, JF Everitt, HO AF Smith, Eric R. Gruber, John B. Wellenius, Patrick Muth, John F. Everitt, Henry O. TI Spectra and energy levels of Eu(3+) in cubic phase Gd(2)O(3) SO PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS LA English DT Article DE crystal field calculations; photoluminescence; rare earth doped semiconductors ID LANTHANIDE AQUO IONS; CRYSTAL-FIELD ANALYSIS; RARE-EARTH IONS; THIN-FILM PHOSPHORS; EU3+-DOPED GD2O3; OPTICAL-SPECTRA; Y2O3; NANOPARTICLES; NANOCRYSTALS; LUMINESCENCE AB In pulsed laser deposition of the sesquioxide semiconductor Gd(2)O(3), adjusting the chamber oxygen pressure controls the crystalline structure of the host. This technique was used to deposit thin films of nominally 16% by weight europium-doped, cubic phase Gd(2)O(3) using 50m Torr of oxygen Structural measurements using high-resolution transmission electron microscopy and selected area electron diffraction confirm the films were polycrystalline, cubic phase Eu:Gd(2)O(3). The spectroscopic assignment of emission lines to specific radiative transitions within the trivalent Eu ion is confirmed by theoretical analysis of the appropriate crystal field Hamiltonian. Detailed crystal-field splittings are presented for the (5)D(J=0-2) and (7)F(J=0-5) multiplet manifolds of Eu(3+) in this host material. (C) 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim C1 [Everitt, Henry O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Everitt, Henry O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. [Smith, Eric R.] Kratos Def & Secur Solut Inc, Huntsville, AL 35805 USA. [Gruber, John B.] Univ Texas San Antonio, Dept Phys & Astron, San Antonio, TX 78249 USA. [Wellenius, Patrick; Muth, John F.] NC State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. RP Everitt, HO (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. EM henry.o.everitt@us.army.mil RI Everitt, Henry/L-7118-2013; Muth, John/E-9027-2012 OI Everitt, Henry/0000-0002-8141-3768; Muth, John/0000-0002-2488-7721 FU NSF STIR [IIP-0712295, IIP-0848943]; Army's competitive in-house laboratory innovative research program FX The authors acknowledge financial support from NSF STIR IIP-0712295, IIP-0848943, and the Army's competitive in-house laboratory innovative research program. The authors also wish to thank Henry H. Everitt and John V. Foreman for their assistance in obtaining the TIPL and TRPL spectra and Sreerenjini Chandra for her initial help in assembling the tables of spectra. NR 28 TC 6 Z9 6 U1 2 U2 26 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0370-1972 J9 PHYS STATUS SOLIDI B JI Phys. Status Solidi B-Basic Solid State Phys. PD JUL PY 2010 VL 247 IS 7 BP 1807 EP 1813 DI 10.1002/pssb.200945602 PG 7 WC Physics, Condensed Matter SC Physics GA 630HK UT WOS:000280263700049 ER PT J AU Shkuratov, SI Baird, J Talantsev, EF Altgilbers, LL AF Shkuratov, Sergey I. Baird, Jason Talantsev, Evgueni F. Altgilbers, Larry L. TI Electric field-free gas breakdown in explosively driven generators SO PHYSICS OF PLASMAS LA English DT Article ID MAGNETIC PHASE-TRANSITION; SHOCK-WAVE COMPRESSION; IMPLOSION AB All known types of gas discharges require an electric field to initiate them. We are reporting on a unique type of gas breakdown in explosively driven generators that does not require an electric field. (C) 2010 American Institute of Physics. [doi:10.1063/1.3460349] C1 [Shkuratov, Sergey I.; Baird, Jason] Loki Inc, Rolla, MO 65409 USA. [Talantsev, Evgueni F.] Pulsed Power LLC, Lubbock, TX 79416 USA. [Altgilbers, Larry L.] USA, Space & Missile Def Command, Army Forces Strateg Command, Huntsville, AL 35807 USA. [Baird, Jason] Missouri Univ Sci & Technol, Dept Min & Nucl Engn, Rolla, MO 65409 USA. RP Shkuratov, SI (reprint author), Loki Inc, Rolla, MO 65409 USA. EM shkuratov@lokiconsult.com OI Talantsev, Evgeny/0000-0001-8970-7982 NR 14 TC 2 Z9 2 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1070-664X J9 PHYS PLASMAS JI Phys. Plasmas PD JUL PY 2010 VL 17 IS 7 AR 074504 DI 10.1063/1.3460349 PG 3 WC Physics, Fluids & Plasmas SC Physics GA 641FQ UT WOS:000281110600069 ER PT J AU Rawat, A Gust, KA Deng, YP Garcia-Reyero, N Quinn, MJ Johnson, MS Indest, KJ Elasri, MO Perkins, EJ AF Rawat, Arun Gust, Kurt A. Deng, Youping Garcia-Reyero, Natalia Quinn, Michael J., Jr. Johnson, Mark S. Indest, Karl J. Elasri, Mohamed O. Perkins, Edward J. TI From raw materials to validated system: the construction of a genomic library and microarray to interpret systemic perturbations in Northern bobwhite SO PHYSIOLOGICAL GENOMICS LA English DT Article DE toxicogenomics; next generation sequencing; gene orthologs; energy metabolism; dinitrotoluenes ID COLINUS-VIRGINIANUS; GENE-EXPRESSION; PATHWAY IDENTIFICATION; ANNOTATION; EXPOSURE; TOOL; 2,4,6-TRINITROTOLUENE; TOXICITY; ONTOLOGY; PLATFORM AB Rawat A, Gust KA, Deng Y, Garcia-Reyero N, Quinn MJ Jr, Johnson MS, Indest KJ, Elasri MO, Perkins EJ. From raw materials to validated system: the construction of a genomic library and microarray to interpret systemic perturbations in Northern bobwhite. Physiol Genomics 42: 219-235, 2010. First published April 6, 2010; doi: 10.1152/physiolgenomics.00022.2010.-The limited availability of genomic tools and data for nonmodel species impedes computational and systems biology approaches in nonmodel organisms. Here we describe the development, functional annotation, and utilization of genomic tools for the avian wildlife species Northern bobwhite (Colinus virginianus) to determine the molecular impacts of exposure to 2,6-dinitrotoluene (2,6-DNT), a field contaminant of military concern. Massively parallel pyrosequencing of a normalized multitissue library of Northern bobwhite cDNAs yielded 71,384 unique transcripts that were annotated with gene ontology (GO), pathway information, and protein domain analysis. Comparative genome analyses with model organisms revealed functional homologies in 8,825 unique Northern bobwhite genes that are orthologous to 48% of Gallus gallus protein-coding genes. Pathway analysis and GO enrichment of genes differentially expressed in livers of birds exposed for 60 days (d) to 10 and 60 mg/kg/d 2,6-DNT revealed several impacts validated by RT-qPCR including: prostaglandin pathway-mediated inflammation, increased expression of a heme synthesis pathway in response to anemia, and a shift in energy metabolism toward protein catabolism via inhibition of control points for glucose and lipid metabolic pathways, PCK1 and PPARGC1, respectively. This research effort provides the first comprehensive annotated gene library for Northern bobwhite. Transcript expression analysis provided insights into the metabolic perturbations underlying several observed toxicological phenotypes in a 2,6-DNT exposure case study. Furthermore, the systemic impact of dinitrotoluenes on liver function appears conserved across species as PPAR signaling is similarly affected in fathead minnow liver tissue after exposure to 2,4-DNT. C1 [Gust, Kurt A.; Indest, Karl J.; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Environm Lab, EP P, Vicksburg, MS 39180 USA. [Rawat, Arun; Elasri, Mohamed O.] Univ So Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA. [Deng, Youping] SpecPro Inc, Environm Lab, EP P, Vicksburg, MS USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Quinn, Michael J., Jr.; Johnson, Mark S.] USA, Ctr Hlth Promot & Preventat Med, Aberdeen Proving Ground, MD USA. RP Gust, KA (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, EP P, Vicksburg, MS 39180 USA. EM kurt.a.gust@usace.army.mil FU U.S. Army; Mississippi Functional Genomics Network (National Center for Research Resources) [P20 RR-016476]; Engineer Research and Development Center [W912HZ-08-C-0032] FX This work was supported by the U.S. Army Environmental Quality and Installations Basic Research Program and Toxicogenomics Focus Area. We also gratefully acknowledge the support of the Mississippi Functional Genomics Network (National Center for Research Resources Grant P20 RR-016476) and Engineer Research and Development Center Grant W912HZ-08-C-0032. NR 70 TC 16 Z9 16 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 1094-8341 J9 PHYSIOL GENOMICS JI Physiol. Genomics PD JUL PY 2010 VL 42 IS 2 BP 219 EP 235 DI 10.1152/physiolgenomics.00022.2010 PG 17 WC Cell Biology; Genetics & Heredity; Physiology SC Cell Biology; Genetics & Heredity; Physiology GA 621NZ UT WOS:000279586900007 PM 20406850 ER PT J AU Gerhardt, RT Shaffer, BM Dixon, P Pfaff, JA Liker, J Ward, J Mueller, GM AF Gerhardt, Robert T. Shaffer, Brett M. Dixon, Patricia Pfaff, James A. Liker, Jennifer Ward, John Mueller, Gwendolyn M. TI DIAGNOSTIC AND PREDICTIVE VALUES OF THIRST, ANGIOTENSIN II, AND VASOPRESSIN DURING TRAUMA RESUSCITATION SO PREHOSPITAL EMERGENCY CARE LA English DT Article; Proceedings Paper CT Annual Meeting of the Society-for-Academic-Emergency-Medicine CY MAY 14-17, 2009 CL New Orleans, LA SP Soc Acad Emergency Med DE emergency medical services; trauma; triage; thirst; hemorrhagic shock; injury severity; angiotensin; vasopressin ID HEMORRHAGE AB Background. Thirst perception involves neurochemical signals attributed to acute elevation of arginine vasopressin (AVP) and angiotensin II (AT2) levels, and may accompany acute hemorrhage. Objective. To determine whether thirst or plasma AVP or AT2 levels predict hemorrhagic shock, injury severity, or outcome in trauma patients at initial presentation. Methods. This was a prospective case series of adult subjects presenting as trauma activations to an urban level I trauma center. Subjects were included if they were alert and nonintoxicated. During resuscitation, subjects were queried for thirst perception using binary and continuous data formats employing a 100-mm nonhatched visual analog scale. Blood for AT2 and AVP assessment was obtained during initial laboratory collection. Other data were abstracted retrospectively from our trauma registry. Crude and stratified analyses (blunt and penetrating trauma) assessed the correlation of thirst, AVP, and AT2 to the initial shock index, base deficit, blood transfusion requirement, admission, and Injury Severity Score (ISS). Our institutional review board (IRB) granted a waiver of informed consent. Results. Of 105 subjects, the average age was 35 years (95% confidence interval [CI] 32 to 38), with 31% penetrating trauma. For AVP, there was no difference in thirst perception between subjects with normal (59 mm, 95% CI 47 to 71) versus elevated (63 mm, 95% CI 56 to 70) plasma levels. For AT2, results were likewise insignificant for normal (63 mm, 95% CI 56 to 70) versus elevated (58 mm, 95% CI 46 to 70) plasma levels. Thirst, AT2 level, and AVP level demonstrated no correlation to shock index, base deficit, transfusion requirement, hospital admission, or ISS. Conclusion. The results of this study imply that thirst severity and AVP and AT2 plasma levels are not reliable predictors of impending hemorrhagic shock, injury severity, or outcome. The presence or absence of severe thirst should not be employed as a primary marker for dismissing or suspecting incipient shock. C1 [Gerhardt, Robert T.; Liker, Jennifer] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Gerhardt, Robert T.; Shaffer, Brett M.; Pfaff, James A.] San Antonio Uniformed Serv Hlth Educ Consortium, Dept Emergency Med, Brooke Army Med Center, San Antonio, TX USA. [Dixon, Patricia] Lackland AFB, Clin Res & Experimentat Wing, San Antonio, TX USA. [Ward, John] Brooke Army Med Ctr, Dept Clin Invest, San Antonio, TX USA. [Gerhardt, Robert T.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD USA. [Mueller, Gwendolyn M.] San Antonio AirLIFE Inc, San Antonio, TX USA. RP Gerhardt, RT (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM robert.gerhardt@us.army.mil NR 8 TC 1 Z9 1 U1 0 U2 0 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1090-3127 J9 PREHOSP EMERG CARE JI Prehosp. Emerg. Care PD JUL-SEP PY 2010 VL 14 IS 3 BP 317 EP 323 DI 10.3109/10903121003790165 PG 7 WC Emergency Medicine; Public, Environmental & Occupational Health SC Emergency Medicine; Public, Environmental & Occupational Health GA 666MC UT WOS:000283118400005 PM 20507219 ER PT J AU Kim, Y Blank, S AF Kim, Younkyoo Blank, Stephen TI Russia and the Six-Party Process in Korea Moscow's Quest for Great Power Status SO PROBLEMS OF POST-COMMUNISM LA English DT Article ID POLICY; ASIA AB Moscow wants a seat at the table when the future of the Korean peninsula is on the agenda, but Russia's political and economic weakness undercuts its political and economic ambitions in East Asia. C1 [Kim, Younkyoo] Hanyang Univ, Seoul, South Korea. [Blank, Stephen] USA, War Coll, Strateg Studies Inst, Washington, DC USA. RP Kim, Y (reprint author), Hanyang Univ, Seoul, South Korea. NR 65 TC 1 Z9 1 U1 1 U2 1 PU M E SHARPE INC PI ARMONK PA 80 BUSINESS PARK DR, ARMONK, NY 10504 USA SN 1075-8216 J9 PROBL POST-COMMUNISM JI Probl. Post-Communism PD JUL-AUG PY 2010 VL 57 IS 4 BP 37 EP 50 DI 10.2753/PPC1075-8216570403 PG 14 WC Political Science SC Government & Law GA 654VZ UT WOS:000282200400003 ER PT J AU Grier, TL Knapik, JJ Canada, S Canham-Chervak, M Jones, BH AF Grier, T. L. Knapik, J. J. Canada, S. Canham-Chervak, M. Jones, B. H. TI Risk factors associated with self-reported training-related injury before arrival at the US army ordnance school SO PUBLIC HEALTH LA English DT Article DE Ordnance School; Illness; Ethnicity; Cigarettes; Military ID BONE-MINERAL DENSITY; EXERCISE-RELATED INJURIES; CIGARETTE-SMOKING; PHYSICAL-FITNESS; INFANTRY SOLDIERS; YOUNG MEN; WOMEN; AGE; WHITE; EPIDEMIOLOGY AB Objective: This study examined risk factors for self-reported injury incurred before arrival at Ordnance School for advanced individual training (AIT). Study design: During AIT in-processing, soldiers (n = 27,289 men and 3856 women) completed a questionnaire that collected demographic and lifestyle information, and asked if the soldier currently had an injury that would affect their AIT performance. Methods: Potential risk factors for self-reported injury were explored using logistic regression. Results: For men, self-reported injury was associated with older age [odds ratio (OR) >= 30years/17-19 years = 1.9], race (OR Black/Caucasian = 1.2), basic combat training (BCT) site (OR Fort Benning/Fort Jackson = 1.7; OR Fort Leonard Wood/Fort Jackson = 1.6, OR Fort Knox/Fort Jackson = 1.3), smoking on 20 or more days in the 30 days prior to BCT (OR smoker/non-smoker = 1.2) and current illness (OR ill/not ill = 6.2). For women, increased self-reported injury was associated with older age (OR >= 30years/17-19 years = 2.0), BCT site (OR Fort Leonard Wood/Fort Jackson = 1.5) and current illness (OR ill/not ill = 5.8). Conclusions: Certain demographic characteristics and lifestyle behaviours may be identified as injury risk factors on arrival at Ordnance AIT. Published by Elsevier Ltd on behalf of The Royal Society for Public Health. C1 [Grier, T. L.; Knapik, J. J.; Canada, S.; Canham-Chervak, M.; Jones, B. H.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Grier, TL (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Tyson.Grier@us.army.mil NR 50 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0033-3506 J9 PUBLIC HEALTH JI Public Health PD JUL PY 2010 VL 124 IS 7 BP 417 EP 423 DI 10.1016/j.puhe.2010.03.016 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 632IL UT WOS:000280415800008 PM 20557912 ER PT J AU Cohen, SP Rathmell, JP AF Cohen, Steven P. Rathmell, James P. TI Tackling the Technical Challenges That Hinder the Success of Facet Joint Radiofrequency Treatment for Spinal Pain SO REGIONAL ANESTHESIA AND PAIN MEDICINE LA English DT Editorial Material ID LOW-BACK-PAIN; DENERVATION; EFFICACY; TRIAL; PREVALENCE; NEUROTOMY C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol & Crit Care, Baltimore, MD USA. [Cohen, Steven P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rathmell, James P.] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA. [Rathmell, James P.] Harvard Univ, Sch Med, Boston, MA USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu NR 21 TC 3 Z9 3 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1098-7339 J9 REGION ANESTH PAIN M JI Region. Anesth. Pain Med. PD JUL-AUG PY 2010 VL 35 IS 4 BP 327 EP 328 DI 10.1097/AAP.0b013e3181e82d66 PG 2 WC Anesthesiology SC Anesthesiology GA 622EH UT WOS:000279643100001 PM 20588147 ER PT J AU Shafer, D Bergstrom, P AF Shafer, Deborah Bergstrom, Peter TI An Introduction to a Special Issue on Large-Scale Submerged Aquatic Vegetation Restoration Research in the Chesapeake Bay: 2003-2008 SO RESTORATION ECOLOGY LA English DT Article DE mechanized harvest and planting; seagrass; seeds ID EELGRASS ZOSTERA-MARINA; OCEANICA L. DELILE; WATER-QUALITY; HABITAT REQUIREMENTS; WESTERN-AUSTRALIA; SEAGRASS; SUCCESS; MACROPHYTES; ECOSYSTEMS; USA AB The Chesapeake Bay is one of the world's largest estuaries. Dramatic declines in the abundance and distribution of submerged aquatic vegetation (SAV) in the Chesapeake Bay over the last few decades led to a series of management decisions aimed at protecting and restoring SAV populations throughout the bay. In 2003, the Chesapeake Bay Program established a goal of planting 405 ha of SAV by 2008. Realizing that such an ambitious goal would require the development of large-scale approaches to SAV restoration, a comprehensive research effort was organized, involving federal and state agencies, academia, and the private sector. This effort differs from most other SAV restoration programs due to a strong emphasis on the use of seeds rather than plants as planting stock, a decision based on the relatively low labor requirements of seeding. Much of the research has focused on the development of tools and techniques for using seeds in large-scale SAV restoration. Since this research initiative began, an average of 13.4 ha/year of SAV has been planted in the Chesapeake Bay, compared to an average rate of 3.6 ha/year during the previous 21 years (1983-2003). The costs of conducting these plantings are on a downward trend as the understanding of the limiting factors increases and as new advances are made in applied research and technology development. Although this effort was focused in the Chesapeake Bay region, the tools and techniques developed as part of this research should be widely applicable to SAV restoration efforts in other areas. C1 [Shafer, Deborah] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Bergstrom, Peter] NOAA, Chesapeake Bay Off, Annapolis, MD 21403 USA. RP Shafer, D (reprint author), Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Deborah.J.Shafer@us.army.mil NR 89 TC 12 Z9 17 U1 5 U2 29 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD JUL PY 2010 VL 18 IS 4 BP 481 EP 489 DI 10.1111/j.1526-100X.2010.00689.x PG 9 WC Ecology SC Environmental Sciences & Ecology GA 622NN UT WOS:000279670600010 ER PT J AU Ailstock, MS Shafer, DJ Magoun, AD AF Ailstock, M. Stephen Shafer, Deborah J. Magoun, A. Dale TI Protocols for Use of Potamogeton perfoliatus and Ruppia maritima Seeds in Large-Scale Restoration SO RESTORATION ECOLOGY LA English DT Article DE Potamogeton perfoliatus; restoration; Ruppia maritima; seed germination; submerged aquatic vegetation ID MARINA L EELGRASS; CHESAPEAKE BAY; AQUATIC PLANTS; GERMINATION; GROWTH; POPULATION; DISPERSAL; SYSTEMS; LIFE AB Restoration of submerged aquatic vegetation from seed has been hampered by a lack of information on the appropriate conditions for collecting, processing, and storing seeds prior to dispersal. Seeds must be processed and stored under conditions that maintain seed viability, meet dormancy requirements, and prevent premature germination. This study examined the effects of collection date, processing technique, aeration, storage and induction temperature and salinity, and storage period on seed germination of two mesohaline aquatic species, Potamogeton perfoliatus and Ruppia maritima. Collection date and processing technique were significant factors affecting seed yield from donor populations. Seeds of both species remained viable and germinated best when stored at 4 degrees C, and then exposed to freshwater induction conditions. However, their responses to other factors differed. Aeration during storage was necessary in order to maintain viability of P. perfoliatus seeds, whereas it was unnecessary for R. maritima seeds. Storage in freshwater at 4 degrees C prevented germination of P. perfoliatus seeds, while high salinity during cold storage was necessary to minimize premature germination of R. maritima. Mean germination time of P. perfoliatus was dependent on storage salinity; in contrast, mean germination time of R. maritima seeds was dependent on induction salinity. These differences indicate that the methods required to produce large quantities of underwater plant seed amenable to large-scale restoration efforts must be tailored to the specific requirements of individual species and must consider the range of processes from initial harvest through seed testing prior to field establishment. C1 [Ailstock, M. Stephen] Anne Arundel Community Coll, Arnold, MD 21012 USA. [Shafer, Deborah J.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA. RP Ailstock, MS (reprint author), Anne Arundel Community Coll, 101 Coll Pkwy, Arnold, MD 21012 USA. EM smailstock@aacc.edu NR 60 TC 7 Z9 7 U1 2 U2 23 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD JUL PY 2010 VL 18 IS 4 BP 560 EP 573 DI 10.1111/j.1526-100X.2010.00696.x PG 14 WC Ecology SC Environmental Sciences & Ecology GA 622NN UT WOS:000279670600017 ER PT J AU Ailstock, MS Shafer, DJ Magoun, AD AF Ailstock, M. Stephen Shafer, Deborah J. Magoun, A. Dale TI Effects of Planting Depth, Sediment Grain Size, and Nutrients on Ruppia maritima and Potamogeton perfoliatus Seedling Emergence and Growth SO RESTORATION ECOLOGY LA English DT Article DE nutrients; Potamogeton perfoliatus; Ruppia maritima; sediment grain size; seed burial depth; seedling growth ID ZOSTERA-MARINA L; SUBMERGED AQUATIC VEGETATION; CHESAPEAKE BAY; HABITAT REQUIREMENTS; SAGO PONDWEED; GERMINATION; EELGRASS; LIGHT; WATER; ESTABLISHMENT AB Protocols are now available for seed harvest, storage and germination of several mesohaline and polyhaline species; however, low seedling survival rates point to the need for an increased understanding of factors affecting seedling establishment. Depth of seed burial in sediments and initial seedling growth rates are shown to be limiting factors for photosynthetic competency of Ruppia maritima and Potamogeton perfoliatus. Seedling emergence is inversely proportional to planting depth on sediments ranging in grain size from coarse sands (850 mu m) to silt (63 mu m). Less than 6% of the seeds of either species emerged when buried to a depth of 3 cm in test sediments. Germination was greatest for seeds placed on the surface of sediments; however, these seedlings were subject to displacement because of the weak and fragile roots produced during early growth. Fine sediments may be more favorable for R. maritima seedling establishment, because seedling emergence and height decreased with increasing sediment grain size. Potamogeton perfoliatus seedlings seem to be more tolerant of a wider range of sediment grain sizes than R. maritima as indicated by the lack of an effect of sediment grain size on P. perfoliatus seed emergence, seedling height, and biomass. Increasing nutrients stimulated seedlings of both species; however, even at the highest concentrations tested, growth, as determined by shoot elongation and leaf and root formation, slowed within 7-10 days. This suggests factors other than mineral nutrients and light limit growth or that growth shifts from aboveground biomass production to belowground vegetative spread. C1 [Ailstock, M. Stephen] Anne Arundel Community Coll, Arnold, MD 21012 USA. [Shafer, Deborah J.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA. RP Ailstock, MS (reprint author), Anne Arundel Community Coll, 101 Coll Pkwy, Arnold, MD 21012 USA. EM smailstock@aacc.edu NR 52 TC 14 Z9 14 U1 1 U2 21 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD JUL PY 2010 VL 18 IS 4 BP 574 EP 583 DI 10.1111/j.1526-100X.2010.00697.x PG 10 WC Ecology SC Environmental Sciences & Ecology GA 622NN UT WOS:000279670600018 ER PT J AU Koch, EW Ailstock, MS Booth, DM Shafer, DJ Magoun, AD AF Koch, Evamaria W. Ailstock, M. Stephen Booth, Dale M. Shafer, Deborah J. Magoun, A. Dale TI The Role of Currents and Waves in the Dispersal of Submersed Angiosperm Seeds and Seedlings SO RESTORATION ECOLOGY LA English DT Article DE currents; dispersal; recruitment; sand; SAV; sediment; seedlings; seeds; waves ID EELGRASS ZOSTERA-MARINA; CHESAPEAKE BAY; GERMINATION; SEAGRASS; MACROPHYTE; RIVER AB We tested the hypothesis that currents, waves, and sediment grain size affect the dispersal of seeds and seedlings of the submersed angiosperms Ruppia maritima, Potamogeton perfoliatus and Stuckenia pectinata. Seed settling velocities and initiation of motion of seeds and seedlings and distance transported were quantified on four sediment types under a range of currents and waves in a flume. The rapid settling velocities of R. maritima and S. pectinata seeds and the increased settling velocity of P. perfoliatus in currents above 8 cm/second suggest that primary dispersal of these species is localized to the general area colonized by their parents. Once settled within a bed, seeds are exposed to weak currents and waves, and are likely to be subject to sediment deposition which may further limit dispersal. In contrast, in restoration projects, the absence of vegetation is likely to make seeds more vulnerable to grazing and transport, and may contribute to the lack of plant establishment. If seeds germinate without being buried, they are susceptible to secondary dispersal at relatively low current velocities and small wave heights due to the drag exerted on the cotyledon. Sand grains tend to stick to the seed coat and rootlet of P. perfoliatus seedlings, perhaps a mechanism to reduce the chances of being displaced following germination. These data reveal the close links between sediment, water flow, and submersed angiosperm seedling establishment; these parameters should be considered when using seeds for restoration of submersed angiosperms. C1 [Koch, Evamaria W.; Booth, Dale M.] Univ Maryland, Ctr Environm Sci, Horn Point Lab, Cambridge, MD 21613 USA. [Ailstock, M. Stephen] Anne Arundel Community Coll, Arnold, MD 21012 USA. [Shafer, Deborah J.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA. RP Koch, EW (reprint author), Univ Maryland, Ctr Environm Sci, Horn Point Lab, POB 775, Cambridge, MD 21613 USA. EM koch@umces.edu FU U.S. Army Corps of Engineers, Engineer Research and Development Center FX Financial support for this project was provided by the U.S. Army Corps of Engineers, Engineer Research and Development Center. Sarah Keating carefully quantified the sand grains on the roots and seed coats of the seedlings. Mark Fonseca and an anonymous reviewer provided valuable input in an earlier version of this paper. NR 39 TC 25 Z9 27 U1 0 U2 28 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1061-2971 J9 RESTOR ECOL JI Restor. Ecol. PD JUL PY 2010 VL 18 IS 4 BP 584 EP 595 DI 10.1111/j.1526-100X.2010.00698.x PG 12 WC Ecology SC Environmental Sciences & Ecology GA 622NN UT WOS:000279670600019 ER PT J AU Fanning, WJ AF Fanning, William J., Jr. TI The Historical Death Ray and Science Fiction in the 1920s and 1930s SO SCIENCE-FICTION STUDIES LA English DT Article AB The death ray became a prominent fixture in the science fiction of the 1920s and 1930s, but its popularity originated in something beyond the fertile imaginations of creative artists. Prior to the First World War and continuing up to the Second, frequent news reports publicized inventors who claimed to have developed such a device. Many of the various death rays in sf novels, short stories, plays, films, and on radio programs of the period bore striking similarities to the futuristic weapons of the "coming war" as described in the news media. C1 [Fanning, William J., Jr.] USA, Infantry Sch, Ft Benning, GA USA. RP Fanning, WJ (reprint author), All St Episcopal Sch, Ft Worth, TX USA. NR 78 TC 0 Z9 0 U1 0 U2 3 PU SCIENCE-FICTION STUDIES PI GREENCASTLE PA DEPAUW UNIV, DEPT ROMANCE LANGUAGES, GREENCASTLE, IN 46135-0037 USA SN 0091-7729 J9 SCI-FICTION STUD JI Sci.-Fict. Stud. PD JUL PY 2010 VL 37 BP 253 EP 274 PN 2 PG 22 WC Literature SC Literature GA 621ZR UT WOS:000279626300005 ER PT J AU Wade, CE AF Wade, Charles E. TI PRIOR EXERCISE ALTERS RESPONSES TO HEMORRHAGE SO SHOCK LA English DT Article DE Cardiac output; blood pressure; vasopressin; catecholamines; plasma renin activity ID BODY NEGATIVE-PRESSURE; HEAD-DOWN TILT; SINGLE BOUT; NEUROENDOCRINE RESPONSES; CARDIOVASCULAR-RESPONSE; CONSCIOUS RABBIT; INTENSE EXERCISE; MAXIMAL EXERCISE; DYNAMIC EXERCISE; MOTOR-VEHICLES AB Traumatic injuries often occur to individuals while exercising. The author sought to determine whether exercise before injury resulting in hemorrhage would alter cardiovascular, metabolic, and neuroendocrine responses. Fifteen chronically instrumented splenectomized immature female swine were trained to run on a treadmill at 70% of maximum heart rate for 60 min. In six swine, responses to exercise were evaluated and found to return to baseline after 60 min of recovery. Swine were then randomly assigned to exercise (n = 7) or rest (n = 8) followed by hemorrhage of 25 mL/kg for 60 min then observed for an additional 60 min. The decrease in mean arterial pressure (MAP) was less after exercise, 26 +/- 9 mmHg compared with 49 +/- 2 mmHg with rest, with the difference sustained during the posthemorrhage period. Cardiac output decreased similarly in both groups. Posthemorrhage lactate and glucose concentrations were lower in exercise. The increase in plasma epinephrine was reduced in exercise, with significantly lower levels in epinephrine and norepinephrine noted posthemorrhage. Vasopressin levels and plasma renin activity were not different. In response to hemorrhage after exercise, blood pressure is better maintained although catecholamine levels were reduced, suggesting increased adrenoreceptor sensitivity. In addition, indices of increased glucose utilization and correction of lactate acidosis support a metabolic shift after exercise. Prior exercise alters responses to hemorrhage that mask the extent of hypovolemia and should be considered in the initial evaluation of a patient with hemorrhage caused by traumatic injuries. C1 [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Dept Surg, Houston, TX USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr Houston, Ctr Translat Injury Res, Houston, TX USA. [Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Wade, CE (reprint author), Univ Texas Hlth, Ctr Translat Injury Res, 6431 Fannin,MSB 5-206, Houston, TX 77030 USA. EM Charles.E.Wade@uth.tmc.edu NR 29 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUL PY 2010 VL 34 IS 1 BP 68 EP 74 DI 10.1097/SHK.0b013e3181cd8ce3 PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 613ZQ UT WOS:000279024500012 PM 19997051 ER PT J AU Mao, JD Palazzo, AJ Olk, DC Clapp, CE Senesi, N Bashore, TL Cao, XY AF Mao, Jingdong Palazzo, Antonio J. Olk, Dan C. Clapp, C. Edward Senesi, Nicola Bashore, Terry L. Cao, Xiaoyan TI Chemical Structure of Soil Organic Matter in Slickspots as Investigated by Advanced Solid-State NMR SO SOIL SCIENCE LA English DT Article DE Humic acids; nuclear magnetic resonance; chemical structure; slickspot soils; soil layers ID NUCLEAR-MAGNETIC-RESONANCE; HUMIC SUBSTANCES; C-13 NMR; ACID PROPERTIES; SPECTROSCOPY; MINERALIZATION; QUANTITATION; CONTAMINANT; FRACTIONS; SELECTION AB Slickspot soils are saline, and knowledge of their humic chemistry would contribute to our limited understanding how salinity affects soil C and N stocks. We characterized humic acids (HA) from slickspot soils with solid-state (13)C nuclear magnetic resonance (NMR). Expanding on previous use of cross polarization/ magic angle spinning (CP/MAS) NMR, we used direct polarization (DP) and yet more advanced spectral editing techniques to identify specific functional groups, detect the connectivities of different functional groups, and selectively observe fused ring carbons. A series of soil HA was extracted from soil layers having different physical properties: silt texture, vesicular structure, and clay texture. They were compared with HA from corresponding depths in soils adjacent to the slickspots. All HA consisted of five main structural components: aliphatic chains, peptides, sugar rings, lignin residues, and aromatics/olefinics. For all soils, except one outside slickspots, the HA from the vesicular and clay layers contained less nonpolar alkyls and more aromatics than those from surface silt layers, but their spectral proportions differed when the (13)C NMR was performed using CP/MAS instead of DP. Humic acids from the surface layers inside the slickspots had lower aromaticity than those from outside the slickspots. Advanced spectral editing techniques allowed for the selection of non-protonated carbons and mobile groups, alkyls, CH, and CH(2) groups, which would otherwise be buried in the heavily overlapped spectrum. They provided more structural information than was obtained by routine (13)C CP/MAS or DP. C1 [Mao, Jingdong; Cao, Xiaoyan] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. [Palazzo, Antonio J.] USACOE, Cold Reg Res & Engn Lab, Hanover, NH USA. [Olk, Dan C.] ARS, USDA, Natl Lab Agr & Environm, Ames, IA USA. [Clapp, C. Edward] Univ Minnesota, Dept Soil Water & Climate, St Paul, MN 55108 USA. [Clapp, C. Edward] ARS, USDA, St Paul, MN USA. [Senesi, Nicola] Univ Bari, Dipartimento Biol & Chim Agroforestale & Ambienta, Bari, Italy. [Bashore, Terry L.] HQ Air Combat Command, Airspace Ranges & Air Field Operat Div, Langley AFB, VA USA. RP Mao, JD (reprint author), Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA. EM jmao@odu.edu RI Cao, Xiaoyan/E-3492-2012 OI Cao, Xiaoyan/0000-0001-7571-6482 FU National Science Foundation [EAR-0843996, CBET-0853950]; Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust; Airspace, Ranges, and Airfield Operations Division, HQ Air Combat Command, Langley AFB, VA FX This work was supported by the National Science Foundation (EAR-0843996 and CBET-0853950), the Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust, and by the Airspace, Ranges, and Airfield Operations Division, HQ Air Combat Command, Langley AFB, VA. The opinions and conclusions in this article are those of the authors and do not necessarily reflect those of the U.S. Air Force, U.S. Army, or the federal government. The authors also thank Prof. Klaus Schmidt-Rohr for his kind support. NR 47 TC 10 Z9 10 U1 4 U2 26 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-075X J9 SOIL SCI JI Soil Sci. PD JUL PY 2010 VL 175 IS 7 BP 329 EP 338 DI 10.1097/SS.0b013e3181e93d23 PG 10 WC Soil Science SC Agriculture GA 622CR UT WOS:000279637000003 ER PT J AU Weeks, A Leshin, JA Dretchen, KL Skowronski, EW O'Connell, KP AF Weeks, Andrea Leshin, Jonathan A. Dretchen, Kenneth L. Skowronski, Evan W. O'Connell, Kevin P. TI Population-level variation of the preproricin gene contradicts expectation of neutral equilibrium for generalist plant defense toxins SO TOXICON LA English DT Article DE Defense gene; Gene family evolution; Preproricin; Ricinus communis; Type II ribosome-inactivating protein ID RIBOSOME-INACTIVATING PROTEINS; RICIN-A-CHAIN; ACTIVE-SITE; LINKAGE DISEQUILIBRIUM; NUCLEOTIDE DIVERSITY; MOLECULAR EVOLUTION; DNA POLYMORPHISM; SEQUENCE; POLYMERASE; COMMUNIS AB The preproricin gene encodes ricin, the highly toxic, type II ribosome-inactivating protein of castor bean (Ricinus communis L). As a generalist plant defense gene, preproricin is expected to exhibit population-level variation consistent with the neutral equilibrium model and to comprise few functionally different alleles. We first test the hypothesis that the preproricin gene family should comprise six to eight members by searching the publicly available draft genome sequence of R. communis and analyzing its ricin-like loci. We then test the neutral equilibrium expectation for the preproricin gene by characterizing its allelic variation among 25 geographically diverse castor bean plants. We confirm the presence of six ricin-like loci that share with the preproricin gene 62.9-96.3% nucleotide identity and intact A-chains. DNA sequence variation among the preproricin haplotypes significantly rejects tests of the neutral equilibrium model. Replacement mutations preserve the 12 amino acids known to affect catalytic and electrostatic interactions of the native protein toxin, which suggests functional divergence among alleles has been minimal. Nucleotide polymorphism is maintained by purifying selection (omega < 0.3) yet includes an excess of rare silent mutations greater than predicted by the neutral equilibrium model. Development of robust detection methods for ricin contamination must account for the presence of these other ricin-like molecules and should leverage the specificity provided by the numerous single nucleotide polymorphisms in the preproricin gene. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Weeks, Andrea] George Mason Univ, Dept Environm Sci & Policy, Fairfax, VA 22030 USA. [Leshin, Jonathan A.] Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA. [Dretchen, Kenneth L.] Georgetown Univ, Dept Pharmacol, Washington, DC 20057 USA. [Skowronski, Evan W.; O'Connell, Kevin P.] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Weeks, A (reprint author), George Mason Univ, Dept Environm Sci & Policy, 4400 Univ Dr,MSN 5F2, Fairfax, VA 22030 USA. EM aweeks3@gmu.edu OI Weeks, Andrea/0000-0002-0000-4541 NR 53 TC 2 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD JUL PY 2010 VL 55 IS 8 BP 1475 EP 1483 DI 10.1016/j.toxicon.2010.03.001 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 609RI UT WOS:000278674400007 PM 20211195 ER PT J AU Liu, K Ayers, P Howard, H Jones, R Anderson, A AF Liu, K. Ayers, P. Howard, H. Jones, R. Anderson, A. TI PREDICTION OF RUT DEPTH DURING MILITARY VEHICLE TURNING MANEUVERS USING A MODIFIED SINKAGE NUMERIC SO TRANSACTIONS OF THE ASABE LA English DT Article DE Modeling; Off-road vehicle; Rut depth; Turning radius; Vehicle terrain interface model ID COMPACTION; CORN AB Vehicle-induced ruts can cause severe adverse effects on soil and vegetation and reduce a vehicle's mobility potential. Vehicle turning factors including turning radius, velocity, and dynamic weight effects were integrated into the Vehicle Terrain Interaction (VTI) terrain mechanics model to predict rut formation during vehicle turning operations on yielding soils. In the modified VTI model, the resultant force on a single tire is a dynamic variable correlated with the vehicle's dynamic weight, velocity, and turning radius. Field tests using an eight-wheeled light armored vehicle (LA V) were conducted, and the results were analyzed and implemented in a modified VTI sinkage model for turning. The LAV was operated at varying velocities during spiral-pattern turn testing to obtain continuously decreasing radii rutting results. The results of the LAV field tests were analyzed with predictions from the modified VTI, and the conclusion shows that the modified model can he used to predict the influence of turning on soil rutting. Rut depths for both vehicle tracks were predicted for turning operations. Results show a tremendous improvement in prediction of rut depth using the modified VTI model, which includes the effect of turning. C1 [Liu, K.; Ayers, P.] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Howard, H.; Anderson, A.] USA, Construct Engn Res Lab, Engn Res & Dev Ctr, Champaign, IL 61824 USA. [Jones, R.] USA, Geotech & Struct Lab, Engn Res & Dev Ctr, Vicksburg, MS USA. RP Ayers, P (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM pdayers@utk.edu FU Environmental Security Technology Certification Program (ESTCP) [SI-0815] FX We are grateful to the Environmental Security Technology Certification Program (ESTCP) project SI-0815 for providing support for this study. NR 14 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 0001-2351 J9 T ASABE JI Trans. ASABE PD JUL-AUG PY 2010 VL 53 IS 4 BP 1019 EP 1024 PG 6 WC Agricultural Engineering SC Agriculture GA 654UZ UT WOS:000282197700001 ER PT J AU StOrmer, M Brachert, J de Korte, D McDonald, C Wendel, S Wood, EM Arroyo, A Devine, D Epstein, JS Gabriel, C Cohava, C Goodrich, R Hanschmann, KM Heath, DG Jacobs, MR Keil, S Lambrecht, B Lee, CK Marcelis, J Marschner, S McGuane, S Mckee, M Muller, T Muthivhi, T Pettersson, A Radziwon, P Ramirez-Arcos, S Reesink, HW Rojo, J Rood, I Schmidt, M AF Stoermer, M. Brachert, J. de Korte, D. McDonald, C. Wendel, S. Wood, E. M. Arroyo, A. Devine, D. Epstein, J. S. Gabriel, C. Cohava, C. Goodrich, R. Hanschmann, K-M Heath, D. G. Jacobs, M. R. Keil, S. Lambrecht, B. Lee, C-K Marcelis, J. Marschner, S. McGuane, S. Mckee, M. Mueller, T. Muthivhi, T. Pettersson, A. Radziwon, P. Ramirez-Arcos, S. Reesink, H. W. Rojo, J. Rood, I Schmidt, M. TI ISBT INTERNATIONAL VALIDATION STUDY ON BLOOD-BACTERIA-STANDARDS (TRANSFUSION-RELEVANT BACTERIAL STRAIN PANEL) SO VOX SANGUINIS LA English DT Meeting Abstract C1 [Stoermer, M.; Brachert, J.; Hanschmann, K-M] Paul Ehrlich Inst, Fed Inst Vaccines & Biomed, D-6070 Langen, Germany. [de Korte, D.; Marcelis, J.; Rood, I] Sanquin Blood Supply Fdn, Amsterdam, Netherlands. [McDonald, C.; McGuane, S.] NHS Blood & Transplant, London, England. [Wendel, S.] Hosp Sirio Libanes, Sao Paulo, Brazil. [Wood, E. M.] Australian Red Cross Blood Serv, Melbourne, Vic, Australia. [Arroyo, A.; Rojo, J.] Ctr Nacl Transfus Sanguinea, Mexico City, DF, Mexico. [Devine, D.; Ramirez-Arcos, S.] Canadian Blood Serv, Ottawa, ON, Canada. [Epstein, J. S.] US FDA, Rockville, MD 20857 USA. [Gabriel, C.] Blutzent Linz, Austrian Red Cross, Linz, Austria. [Cohava, C.; Mckee, M.] Amer Type Culture Collect, Manassas, VA USA. [Goodrich, R.; Keil, S.; Marschner, S.] CaridianBCT Biotechnol, Lakewood, CO USA. [Heath, D. G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Jacobs, M. R.] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA. [Lambrecht, B.; Mueller, T.] NSTOB, German Red Cross, Springe, Germany. [Lee, C-K] Hong Kong Red Cross Blood Transfus Serv, Hong Kong, Hong Kong, Peoples R China. [Muthivhi, T.] South African Natl Blood Serv, Weltevreden Pk, South Africa. [Pettersson, A.] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands. [Radziwon, P.] Reg Ctr Transfus Med, Bialystok, Poland. [Reesink, H. W.] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands. [Schmidt, M.] German Red Cross, Frankfurt, Germany. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0042-9007 J9 VOX SANG JI Vox Sang. PD JUL PY 2010 VL 99 SU 1 BP 309 EP 310 PG 2 WC Hematology SC Hematology GA 625DE UT WOS:000279872501374 ER PT J AU Bruttig, S Ho, D Sondeen, J Gadsden, I Dubick, M AF Bruttig, S. Ho, D. Sondeen, J. Gadsden, I Dubick, M. TI DESICCATED AND REHYDRATED HUMAN RED BLOOD CELLS CAN CARRY AND DELIVER OXYGEN SO VOX SANGUINIS LA English DT Meeting Abstract C1 [Bruttig, S.; Ho, D.; Gadsden, I] HeMem BioTech, Rockville, MD USA. [Sondeen, J.; Dubick, M.] USA, Inst Surg Res, Ft Sam Houston, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0042-9007 J9 VOX SANG JI Vox Sang. PD JUL PY 2010 VL 99 SU 1 BP 483 EP 484 PG 2 WC Hematology SC Hematology GA 625DE UT WOS:000279872502399 ER PT J AU Bruscino, T AF Bruscino, Thomas TI War and Genocide in Cuba, 1895-1898 SO WAR IN HISTORY LA English DT Book Review C1 [Bruscino, Thomas] USA, Sch Adv Mil Studies, Washington, DC 20310 USA. RP Bruscino, T (reprint author), USA, Sch Adv Mil Studies, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD JUL PY 2010 VL 17 IS 3 BP 359 EP 361 PG 3 WC History; International Relations SC History; International Relations GA 616SV UT WOS:000279230200011 ER PT J AU Zabecki, DT AF Zabecki, David T. TI America's Deadliest Battle: Meuse-Argonne, 1918 SO WAR IN HISTORY LA English DT Book Review C1 [Zabecki, David T.] Univ Birmingham, Birmingham B15 2TT, W Midlands, England. [Zabecki, David T.] USA, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0968-3445 J9 WAR HIST JI War Hist. PD JUL PY 2010 VL 17 IS 3 BP 372 EP 373 PG 2 WC History; International Relations SC History; International Relations GA 616SV UT WOS:000279230200016 ER PT J AU Trego, LL Jordan, PJ AF Trego, Lori L. Jordan, Patricia J. TI Military Women's Attitudes Toward Menstruation and Menstrual Suppression in Relation to the Deployed Environment: Development and Testing of the MWATMS-9 (Short Form) SO WOMENS HEALTH ISSUES LA English DT Article ID LONG-CYCLE TREATMENT; ORAL-CONTRACEPTIVES; HEALTH-CARE; SYMPTOMS; FREQUENCY; STRESS; LIFE AB Purpose: To determine military women's attitudes toward menstruation and menstrual suppression with oral contraceptives in the deployed environment. Methods: A cross-sectional descriptive design with the administration of the Menstrual Attitude Questionnaire (MAQ) and the 55-item Military Women's Attitudes Towards Menstrual Suppression Scale (MWATMS) to a convenience sample (n = 278) of women in the U.S. Army with deployment experience. Findings: The MAQ's five subscales' mean scores ranged from 3.4 (+/- 1.11) to 5.1 (+/- 1.06), indicating neutral to moderate attitudes toward menstruation. Measurement development on the MWATMS produced a nine-item scale with three components: stress effects, benefits to self, and environmental barriers. Conclusion: Menstrual attitudes were generally neutral in this sample; however, military women favor menstrual suppression during deployment owing to the effects of stress during deployment, benefits that suppression would provide, and the barriers to menstrual hygiene in the deployed environment. Women who perceived menstruation as bothersome and debilitating had positive attitudes toward menstrual suppression. These findings can contribute to appropriate predeployment women's health care and improve the readiness for deployment in female soldiers. Providers should educate women on the risks and benefits of menstrual suppression methods and provide guidance on impact that the deployed environment can have on their menstrual experiences. Copyright (C) 2010 by the Jacobs Institute of Women's Health. Published by Elsevier Inc. C1 [Trego, Lori L.] USA, Nurse Corps, Tripler Army Med Ctr, Nursing Support Serv, Tamc, HI 96859 USA. [Jordan, Patricia J.] Pacific Telehlth & Technol Hui, Honolulu, HI USA. RP Trego, LL (reprint author), USA, Nurse Corps, Tripler Army Med Ctr, Nursing Support Serv, 1 Jarrett White Rd, Tamc, HI 96859 USA. EM Lori.trego@us.army.mil NR 31 TC 7 Z9 7 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1049-3867 J9 WOMEN HEALTH ISS JI Womens Health Iss. PD JUL-AUG PY 2010 VL 20 IS 4 BP 287 EP 293 DI 10.1016/j.whi.2010.03.002 PG 7 WC Public, Environmental & Occupational Health; Women's Studies SC Public, Environmental & Occupational Health; Women's Studies GA 626SP UT WOS:000279987500011 PM 20627773 ER PT J AU Crane, NJ Brown, TS Evans, KN Hawksworth, JS Hussey, S Tadaki, DK Elster, EA AF Crane, Nicole J. Brown, Trevor S. Evans, Korboi N. Hawksworth, Jason S. Hussey, Sean Tadaki, Doug K. Elster, Eric A. TI Monitoring the healing of combat wounds using Raman spectroscopic mapping SO WOUND REPAIR AND REGENERATION LA English DT Article ID TARGET ENTROPY MINIMIZATION; IN-VIVO; TISSUE; MICROSCOPY; MIXTURES; BIOLOGY AB Soldiers wounded in modern warfare present with extensive and complicated acute wounds, confounded by an overwhelming inflammatory response. The pathophysiology of acute wounds is unknown and timing of wound closure remains subjective. Collagen gene expression profiles are presented for 24 patients. Impaired healing wounds showed a twofold decrease in the up-regulation of COL1A1 and COL3A1 genes in the beginning of the wound healing process, compared with normal healing wounds. By the final debridement, however, collagen gene expression profiles for normal and impaired healing wounds were similar for COL1A1 and COL3A1. In addition, Raman spectroscopic maps were collected of biopsy tissue sections, from the first and last debridements of 10 wounds collected from nine patients. Tissue components obtained for the debridement biopsies were compared to elucidate whether or not a wound healed normally. Raman spectroscopy showed a loss of collagen in five patients, indicated by a negative percent difference in the 1,665/1,445 cm-1 band area ratios. Four healed patients showed an increased or unchanged collagen content. Here, we demonstrate the potential of Raman spectroscopic analysis of wound biopsies for classification of wounds as normal or impaired healing. Raman spectroscopy has the potential to noninvasively monitor collagen deposition in the wound bed, during surgical wound debridements, to help determine the optimal time for wound closure. C1 [Crane, Nicole J.; Brown, Trevor S.; Tadaki, Doug K.; Elster, Eric A.] Naval Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA. [Hussey, Sean] Natl Naval Med Ctr, Dept Pathol, Bethesda, MD USA. [Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Elster, Eric A.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. [Hawksworth, Jason S.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Evans, Korboi N.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Elster, EA (reprint author), Naval Med Res Ctr, Regenerat Med Dept, Silver Spring, MD 20910 USA. EM eric.elster@med.navy.mil RI Brown, Trevor/K-4703-2012; Brown, Trevor/F-7392-2015 OI Brown, Trevor/0000-0001-7042-785X; Brown, Trevor/0000-0001-7042-785X FU [604771N.0933.001.A0604] FX The authors would like to thank Dr. Thomas Davis for his role in developing the gene expression assay used in this manuscript. This work was prepared as part of the authors' official duties. Title 17 U.S.C. 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a US Government work as a work prepared by a military service member or employee of the US Government as part of that person's official duties. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the US Government. This work was supported and funded by work unit number 604771N.0933.001.A0604. NR 32 TC 16 Z9 16 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1067-1927 J9 WOUND REPAIR REGEN JI Wound Repair Regen. PD JUL-AUG PY 2010 VL 18 IS 4 BP 409 EP 416 DI 10.1111/j.1524-475X.2010.00597.x PG 8 WC Cell Biology; Dermatology; Medicine, Research & Experimental; Surgery SC Cell Biology; Dermatology; Research & Experimental Medicine; Surgery GA 619UB UT WOS:000279454700082 PM 20546554 ER PT J AU Ciezak, JA Trevino, SF AF Ciezak, Jennifer A. Trevino, S. F. TI Analysis of the vibrational spectrum of dihydrazinium 5,5 '-azotetrazolate dihydrate by electronic structure calculations SO JOURNAL OF MOLECULAR STRUCTURE LA English DT Article DE Dihydrazinium 5,5 '-azotetrazolate dihydrate; Energetic material; High-nitrogen material; Vibrational spectroscopy; Inelastic neutron scattering spectroscopy; Solid-state density functional theory ID INELASTIC NEUTRON-SCATTERING; HOT-SPOT FORMATION; LIQUID NITROMETHANE; ENERGETIC MATERIALS; EXPLOSIVES; SPECTROSCOPY; RAMAN; CRYSTALS; DYNAMICS; IMPACT AB The structure of the high-nitrogen material, dihydrazinium 5,5'-azotetrazolate dihydrate (HAT), was determined by neutron diffraction at 25 K and reveals no significant deviations from the previously reported room temperature structure determined from X-ray diffraction. The vibrational spectrum of HAT was measured at 25 K by inelastic neutron scattering (INS) spectroscopy. Solid-state quantum chemical calculations were used to simulate the INS spectrum of HAT and on the basis of the simulations and analysis of the experimental data, it was possible to assign the normal modes. A possible 'doorway mode' was found in the energy range defined by the lattice modes and the implications for the decomposition mechanism of HAT is discussed. Published by Elsevier B.V. C1 [Ciezak, Jennifer A.; Trevino, S. F.] USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak, JA (reprint author), USA, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA. EM Jennifer.ciezak@us.army.mil FU National Institute of Standards and Technology, US Department of Commerce FX We acknowledge the support of the National Institute of Standards and Technology, US Department of Commerce, in providing the neutron research facilities used in this work. The Wright Patterson Major Shared Resource Center is thanked for providing access to the DMoI3. A portion of the work was performed while J.C. was under a National Research Council Fellowship with the US Army Research Laboratory. NR 38 TC 1 Z9 2 U1 1 U2 9 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2860 J9 J MOL STRUCT JI J. Mol. Struct. PD JUN 30 PY 2010 VL 975 IS 1-3 BP 23 EP 29 DI 10.1016/j.molstruc.2010.03.072 PG 7 WC Chemistry, Physical SC Chemistry GA 627GX UT WOS:000280028600004 ER PT J AU Zuniga, JE Hammill, JT Drory, O Nuss, JE Burnett, JC Gussio, R Wipf, P Bavari, S Brunger, AT AF Zuniga, Jorge E. Hammill, Jared T. Drory, Omri Nuss, Jonathan E. Burnett, James C. Gussio, Rick Wipf, Peter Bavari, Sina Brunger, Axel T. TI Iterative Structure-Based Peptide-Like Inhibitor Design against the Botulinum Neurotoxin Serotype A SO PLOS ONE LA English DT Article ID TOXIN TYPE-A; SMALL-MOLECULE INHIBITORS; ALPHA-AMINO-ACIDS; CLOSTRIDIUM-BOTULINUM; SECONDARY STRUCTURE; LIGHT-CHAIN; NEUROTRANSMITTER RELEASE; CONFORMATIONAL-ANALYSIS; SUBSTRATE RECOGNITION; REMARKABLE RESISTANCE AB The botulinum neurotoxin serotype A light chain (BoNT/A LC) protease is the catalytic component responsible for the neuroparalysis that is characteristic of the disease state botulism. Three related peptide-like molecules (PLMs) were designed using previous information from co-crystal structures, synthesized, and assayed for in vitro inhibition against BoNT/A LC. Our results indicate these PLMS are competitive inhibitors of the BoNT/A LC protease and their K(i) values are in the nM-range. A co-crystal structure for one of these inhibitors was determined and reveals that the PLM, in accord with the goals of our design strategy, simultaneously involves both ionic interactions via its P1 residue and hydrophobic contacts by means of an aromatic group in the P2' position. The PLM adopts a helical conformation similar to previously determined co-crystal structures of PLMs, although there are also major differences to these other structures such as contacts with specific BoNT/A LC residues. Our structure further demonstrates the remarkable plasticity of the substrate binding cleft of the BoNT/A LC protease and provides a paradigm for iterative structure-based design and development of BoNT/A LC inhibitors. C1 [Zuniga, Jorge E.; Drory, Omri; Brunger, Axel T.] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Drory, Omri; Brunger, Axel T.] Stanford Univ, Dept Mol & Cellular Physiol, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Drory, Omri; Brunger, Axel T.] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Drory, Omri; Brunger, Axel T.] Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Drory, Omri; Brunger, Axel T.] Stanford Univ, Dept Photon Sci, Stanford, CA 94305 USA. [Hammill, Jared T.; Wipf, Peter] Univ Pittsburgh, Ctr Chem Methodol & Lib Dev, Pittsburgh, PA USA. [Nuss, Jonathan E.; Bavari, Sina] USA, Med Res Inst Infect Dis, Div Bacteriol, Dept Immunol Target Identificat & Translat Res, Frederick, MD USA. [Burnett, James C.] NCI, Target Struct Based Drug Discovery Grp, Frederick, MD 21701 USA. [Gussio, Rick] NCI, Informat Technol Branch, Dev Therapeut Program, Frederick, MD 21701 USA. RP Zuniga, JE (reprint author), Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA. EM pwipf@pitt.edu; brunger@stanford.edu OI Brunger, Axel/0000-0001-5121-2036 FU Howard Hughes Medical Institute; Department of Defense FX This work was supported by the Howard Hughes Medical Institute and the Department of Defense (proposal number 3.10024_06_RD_B to A.T.B.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 61 TC 14 Z9 14 U1 0 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 30 PY 2010 VL 5 IS 6 AR e11378 DI 10.1371/journal.pone.0011378 PG 15 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 618QE UT WOS:000279370000009 PM 20614028 ER PT J AU Shoemaker, JE Gayen, K Garcia-Reyero, N Perkins, EJ Villeneuve, DL Liu, L Doyle, FJ AF Shoemaker, Jason E. Gayen, Kalyan Garcia-Reyero, Natalia Perkins, Edward J. Villeneuve, Daniel L. Liu, Li Doyle, Francis J., III TI Fathead minnow steroidogenesis: in silico analyses reveals tradeoffs between nominal target efficacy and robustness to cross-talk SO BMC SYSTEMS BIOLOGY LA English DT Article ID GONADOTROPIN-RELEASING-HORMONE; LUTEINIZING-HORMONE; CIRCADIAN CLOCK; BIOCHEMICAL NETWORKS; PIMEPHALES-PROMELAS; PITUITARY CULTURES; GENE-EXPRESSION; MICROARRAY DATA; CAMP BINDING; TESTOSTERONE AB Background: Interpreting proteomic and genomic data is a major challenge in predictive ecotoxicology that can be addressed by a systems biology approach. Mathematical modeling provides an organizational platform to consolidate protein dynamics with possible genomic regulation. Here, a model of ovarian steroidogenesis in the fathead minnow, Pimephales promelas, (FHM) is developed to evaluate possible transcriptional regulation of steroid production observed in microarray studies. Results: The model was developed from literature sources, integrating key signaling components (G-protein and PKA activation) with their ensuing effect on steroid production. The model properly predicted trajectory behavior of estradiol and testosterone when fish were exposed to fadrozole, a specific aromatase inhibitor, but failed to predict the steroid hormone behavior occurring one week post-exposure as well as the increase in steroid levels when the stressor was removed. In vivo microarray data implicated three modes of regulation which may account for over-production of steroids during a depuration phase (when the stressor is removed): P450 enzyme up-regulation, inhibin down-regulation, and luteinizing hormone receptor up-regulation. Simulation studies and sensitivity analysis were used to evaluate each case as possible source of compensation to endocrine stress. Conclusions: Simulation studies of the testosterone and estradiol response to regulation observed in microarray data supported the hypothesis that the FHM steroidogenesis network compensated for endocrine stress by modulating the sensitivity of the ovarian network to global cues coming from the hypothalamus and pituitary. Model predictions of luteinizing hormone receptor regulation were consistent with depuration and in vitro data. These results challenge the traditional approach to network elucidation in systems biology. Generally, the most sensitive interactions in a network are targeted for further elucidation but microarray evidence shows that homeostatic regulation of the steroidogenic network is likely maintained by a mildly sensitive interaction. We hypothesize that effective network elucidation must consider both the sensitivity of the target as well as the target's robustness to biological noise (in this case, to cross-talk) when identifying possible points of regulation. C1 [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Vicksburg, MS USA. [Shoemaker, Jason E.; Gayen, Kalyan; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Villeneuve, Daniel L.] US EPA, Midcontinent Ecol Div, Duluth, MN USA. [Liu, Li] Univ Florida, Interdisciplinary Ctr Biotechnol Res, Gainesville, FL USA. RP Perkins, EJ (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS USA. EM Edward.J.Perkins@usace.army.mil RI Shoemaker, Jason/B-8137-2011 OI Shoemaker, Jason/0000-0003-3315-7103 FU Institute for Collaborative Biotechnologies from the U.S. Army Research Office [DAAD19-03-D-0004]; IGERT NSF [DGE02-21715]; U.S. Army; University of California, Board of Regents FX This work was supported by the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the U. S. Army Research Office, IGERT NSF grant DGE02-21715, the U. S. Army Environmental Quality Technology Research Program, and the University of California, Board of Regents. Permission was granted by the Chief of Engineers to publish this information. NR 55 TC 9 Z9 9 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD JUN 28 PY 2010 VL 4 AR 89 DI 10.1186/1752-0509-4-89 PG 17 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 655NB UT WOS:000282255600001 PM 20579396 ER PT J AU Sergueev, KV He, YX Borschel, RH Nikolich, MP Filippov, AA AF Sergueev, Kirill V. He, Yunxiu Borschel, Richard H. Nikolich, Mikeljon P. Filippov, Andrey A. TI Rapid and Sensitive Detection of Yersinia pestis Using Amplification of Plague Diagnostic Bacteriophages Monitored by Real-Time PCR SO PLOS ONE LA English DT Article ID POLYMERASE-CHAIN-REACTION; ESCHERICHIA-COLI O157-H7; BACILLUS-ANTHRACIS; GENOME SEQUENCE; REACTION ASSAY; MULTIPLEX-PCR; GAMMA-PHAGE; IDENTIFICATION; HYBRIDIZATION; TUBERCULOSIS AB Background: Yersinia pestis, the agent of plague, has caused many millions of human deaths and still poses a serious threat to global public health. Timely and reliable detection of such a dangerous pathogen is of critical importance. Lysis by specific bacteriophages remains an essential method of Y. pestis detection and plague diagnostics. Methodology/Principal Findings: The objective of this work was to develop an alternative to conventional phage lysis tests - a rapid and highly sensitive method of indirect detection of live Y. pestis cells based on quantitative real-time PCR (qPCR) monitoring of amplification of reporter Y. pestis-specific bacteriophages. Plague diagnostic phages phi A1122 and L-413C were shown to be highly effective diagnostic tools for the detection and identification of Y. pestis by using qPCR with primers specific for phage DNA. The template DNA extraction step that usually precedes qPCR was omitted. phi A1122-specific qPCR enabled the detection of an initial bacterial concentration of 10(3) CFU/ml (equivalent to as few as one Y. pestis cell per 1-mu l sample) in four hours. L-413C-mediated detection of Y. pestis was less sensitive (up to 100 bacteria per sample) but more specific, and thus we propose parallel qPCR for the two phages as a rapid and reliable method of Y. pestis identification. Importantly, phi A1122 propagated in simulated clinical blood specimens containing EDTA and its titer rise was detected by both a standard plating test and qPCR. Conclusions/Significance: Thus, we developed a novel assay for detection and identification of Y. pestis using amplification of specific phages monitored by qPCR. The method is simple, rapid, highly sensitive, and specific and allows the detection of only live bacteria. C1 [Sergueev, Kirill V.; He, Yunxiu; Borschel, Richard H.; Nikolich, Mikeljon P.; Filippov, Andrey A.] Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. RP Sergueev, KV (reprint author), Walter Reed Army Inst Res, Dept Emerging Bacterial Infect, Div Bacterial & Rickettsial Dis, Silver Spring, MD USA. EM kirill.sergueev@amedd.army.mil; andrey.filippov@amedd.army.mil RI Filippov, Andrey/B-2856-2011 FU Defense Threat Reduction Agency, Joint Science and Technology Office, Medical ST Division FX This research was supported by the Defense Threat Reduction Agency, Joint Science and Technology Office, Medical S&T Division. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 69 TC 12 Z9 14 U1 1 U2 10 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 28 PY 2010 VL 5 IS 6 AR e11337 DI 10.1371/journal.pone.0011337 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 617DB UT WOS:000279259900010 PM 20596528 ER PT J AU Wright, DJ Pedit, JA Gasda, SE Farthing, MW Murphy, LL Knight, SR Brubaker, GR Miller, CT AF Wright, D. Johnson Pedit, J. A. Gasda, S. E. Farthing, M. W. Murphy, L. L. Knight, S. R. Brubaker, G. R. Miller, C. T. TI Dense, viscous brine behavior in heterogeneous porous medium systems SO JOURNAL OF CONTAMINANT HYDROLOGY LA English DT Article DE DNAPL; Remediation; Instabilities; Fingering; Modeling ID CONCENTRATION-GRADIENT DISPERSION; DEPENDENT GROUNDWATER-FLOW; HELE-SHAW CELL; VARIABLE-DENSITY; SOLUTE TRANSPORT; STOCHASTIC-ANALYSIS; CONTROLLED-RELEASE; BOUNDARY-CONDITION; MISCIBLE FLUIDS; FINITE ELEMENT AB The behavior of dense, viscous calcium bromide brine solutions used to remediate systems contaminated with dense nonaqueous phase liquids (DNAPLs) is considered in laboratory and field porous medium systems. The density and viscosity of brine solutions are experimentally investigated and functional forms fit over a wide range of mass fractions. A density of 1.7 times, and a corresponding viscosity of 6.3 times, that of water is obtained at a calcium bromide mass fraction of 0.53. A three-dimensional laboratory cell is used to investigate the establishment, persistence, and rate of removal of a stratified dense brine layer in a controlled system. Results from a field-scale experiment performed at the Dover National Test Site are used to investigate the ability to establish and maintain a dense brine layer as a component of a DNAPL recovery strategy, and to recover the brine at sufficiently high mass fractions to support the economical reuse of the brine. The results of both laboratory and field experiments show that a dense brine layer can be established, maintained, and recovered to a significant extent. Regions of unstable density profiles are shown to develop and persist in the field-scale experiment, which we attribute to regions of low hydraulic conductivity. The saturated-unsaturated, variable-density groundwater flow simulation code SUTRA is modified to describe the system of interest, and used to compare simulations to experimental observations and to investigate certain unobserved aspects of these complex systems. The model results show that the standard model formulation is not appropriate for capturing the behavior of sharp density gradients observed during the dense brine experiments. (C) 2010 Elsevier B.V. All rights reserved. C1 [Wright, D. Johnson; Pedit, J. A.; Gasda, S. E.; Miller, C. T.] Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. [Farthing, M. W.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Murphy, L. L.] CH2M Hill Inc, Atlanta, GA 30346 USA. [Knight, S. R.; Brubaker, G. R.] AECOM, Morrisville, NC 27560 USA. RP Miller, CT (reprint author), Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA. EM nomad12@email.unc.edu; pedit@email.unc.edu; sgasda@email.unc.edu; matthew.w.farthing@erdc.usace.army.mil; llmurph@gmail.com; sknight@ensr.aecom.com; GBrubaker@ensr.aecom.com; casey_miller@unc.edu RI Miller, Cass T./I-6613-2012 OI Miller, Cass T./0000-0001-6082-9273 FU National Institute of Environmental Health Sciences [P42 ES05948]; AECOM; Dead Sea Bromine Group FX This work was supported by the National Institute of Environmental Health Sciences grant P42 ES05948, AECOM, and the Dead Sea Bromine Group. The Dover National Environmental Technology Test Site is established and managed by the Strategic Environmental Research and Development Program. The demonstration complied with prescribed NETTS protocols and guidelines for quality assurance, health and safety, technical completeness, and regulatory compliance. The support of the NETT'S facilities and test location manager and staff are gratefully acknowledged. NR 95 TC 3 Z9 3 U1 0 U2 17 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7722 J9 J CONTAM HYDROL JI J. Contam. Hydrol. PD JUN 25 PY 2010 VL 115 IS 1-4 BP 46 EP 63 DI 10.1016/j.jconhyd.2010.03.005 PG 18 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA 622YX UT WOS:000279704600005 PM 20444520 ER PT J AU Mrozek, RA Cole, PJ Mondy, LA Rao, RR Bieg, LF Lenhart, JL AF Mrozek, Randy A. Cole, Phillip J. Mondy, Lisa A. Rao, Rekha R. Bieg, Lothar F. Lenhart, Joseph L. TI Highly conductive, melt processable polymer composites based on nickel and low melting eutectic metal SO POLYMER LA English DT Article DE Conductive; Melt-processable; Eutectic AB Highly conductive polymers are difficult to process utilizing standard polymer approaches. This report describes a polymer composite loaded with a eutectic metal that is molten during melt processing along with a more traditional Nickel particulate filler. Conductivities over 300 S/cm were achieved, and 60 vol% metals loading was processable with a single screw extruder. The addition of the Nickel particulate was critical for maintaining eutectic dispersion. We anticipate that this approach will facilitate the implementation of conductive polymers into a broader variety of practical applications, due to the enhanced compatibility with standard polymer processing techniques such as extrusion, melt mixing, and resin transfer-molding operations. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Mrozek, Randy A.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen, MD 21005 USA. [Mrozek, Randy A.; Cole, Phillip J.; Mondy, Lisa A.; Rao, Rekha R.; Bieg, Lothar F.; Lenhart, Joseph L.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Cole, Phillip J.] Northrop Grumman A&AS, Arlington, VA 22209 USA. RP Mrozek, RA (reprint author), USA, Res Lab, Aberdeen, MD 21005 USA. EM randy.mrozek@us.army.mil; joseph.lenhart1@us.army.mil FU ARL through Oak Ridge Institute of Science and Engineering (ORISE); United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX This work was initiated at Sandia National Laboratories by J.L. Lenhart, P.J. Cole, and R.A. Mrozek and is being continued at the US Army Research Laboratory by J.L. Lenhart and R.A. Mrozek. R.A. Mrozek was funded at ARL through a contract with the Oak Ridge Institute of Science and Engineering (ORISE). Sandia is a multi-program laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Commercial equipment and materials are identified in this paper in order to specify adequately the experimental procedures and does not imply recommendations by the Army Research Laboratory. NR 8 TC 17 Z9 17 U1 2 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD JUN 24 PY 2010 VL 51 IS 14 BP 2954 EP 2958 DI 10.1016/j.polymer.2010.04.067 PG 5 WC Polymer Science SC Polymer Science GA 616AZ UT WOS:000279181400003 ER PT J AU Satya, RV Kumar, K Zavaljevski, N Reifman, J AF Satya, Ravi Vijaya Kumar, Kamal Zavaljevski, Nela Reifman, Jaques TI A high-throughput pipeline for the design of real-time PCR signatures SO BMC BIOINFORMATICS LA English DT Article ID BURKHOLDERIA-PSEUDOMALLEI; IDENTIFICATION; MALLEI; VIRUS; TOOL AB Background: Pathogen diagnostic assays based on polymerase chain reaction (PCR) technology provide high sensitivity and specificity. However, the design of these diagnostic assays is computationally intensive, requiring high-throughput methods to identify unique PCR signatures in the presence of an ever increasing availability of sequenced genomes. Results: We present the Tool for PCR Signature Identification (TOPSI), a high-performance computing pipeline for the design of PCR-based pathogen diagnostic assays. The TOPSI pipeline efficiently designs PCR signatures common to multiple bacterial genomes by obtaining the shared regions through pairwise alignments between the input genomes. TOPSI successfully designed PCR signatures common to 18 Staphylococcus aureus genomes in less than 14 hours using 98 cores on a high-performance computing system. Conclusions: TOPSI is a computationally efficient, fully integrated tool for high-throughput design of PCR signatures common to multiple bacterial genomes. TOPSI is freely available for download at http://www.bhsai.org/downloads/topsi.tar.gz. C1 [Satya, Ravi Vijaya; Kumar, Kamal; Zavaljevski, Nela; Reifman, Jaques] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM jaques.reifman@us.army.mil OI Kumar, Kamal/0000-0002-9470-6682 FU U.S. DoD FX This work was sponsored by the U.S. DoD High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes Initiative. We thank Mr. Tom Slezak of Lawrence Livermore National Laboratory for providing us with the PCR signatures designed by KPATH for S. aureus. We also thank Drs. David Kulesh and Leonard Wasieloski of the U. S. Army Medical Research Institute of Infectious Diseases for valuable discussions about the selection of parameters for PCR signature design. The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or the U. S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 19 TC 8 Z9 8 U1 2 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2105 J9 BMC BIOINFORMATICS JI BMC Bioinformatics PD JUN 23 PY 2010 VL 11 AR 340 DI 10.1186/1471-2105-11-340 PG 10 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Mathematical & Computational Biology GA 631FU UT WOS:000280332800001 ER PT J AU Rudin, S AF Rudin, S. TI Temperature dependence of the nonlinear plasma resonance in gated two-dimensional semiconductor conduction channels SO APPLIED PHYSICS LETTERS LA English DT Article DE Boltzmann equation; electromagnetic waves; high electron mobility transistors; Q-factor; sensors; viscosity ID ACOUSTIC-PHONON SCATTERING; FIELD-EFFECT TRANSISTOR; TERAHERTZ RADIATION; ELECTRON-GAS; HETEROSTRUCTURES; EQUATIONS; TRANSPORT; CONTACTS; LIFETIME; FLUID AB In the Dyakonov-Shur detector [IEEE Trans. Electron Devices 43, 380 (1996)] a short channel high electron mobility transistor is used for the detection of electromagnetic radiation in the low terahertz range. The quality of the plasma resonance utilized in such device is strongly temperature dependent. Starting with the Boltzmann equation, we derived the viscous hydrodynamic model with temperature dependent transport coefficients and obtained the temperature dependence of the quality factor of the resonance. We find that in high mobility channels the quality of the resonance is strongly limited by the viscosity of the electron fluid.(C) 2010 American Institute of Physics. [doi:10.1063/1.3455993] C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Rudin, S (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM srudin@arl.army.mil NR 21 TC 7 Z9 7 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 21 PY 2010 VL 96 IS 25 AR 252101 DI 10.1063/1.3455993 PG 3 WC Physics, Applied SC Physics GA 615WF UT WOS:000279168100024 ER PT J AU Sitaraman, J Floros, M Wissink, A Potsdam, M AF Sitaraman, Jayanarayanan Floros, Matthew Wissink, Andrew Potsdam, Mark TI Parallel domain connectivity algorithm for unsteady flow computations using overlapping and adaptive grids SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Overset grid; Domain connectivity; Adaptive grids; Multi-solver paradigm; Parallel execution AB This paper describes the algorithms and functionality of a new module developed to support overset grid assembly associated with performing time-dependent and adaptive moving body calculations of external aerodynamic flows using a multi-solver paradigm (i.e. different CFD solvers in different parts of the computational domain). We use the term "domain connectivity" in this paper to denote all the procedures that are involved in an overset grid assembly, and the module developed is referred henceforth as the domain-connectivity module. The domain-connectivity module coordinates the data transfer between different solvers applied in different parts of the computational domain - body fitted structured or unstructured to capture viscous near-wall effects, and Cartesian adaptive mesh refinement to capture effects away from the wall. The execution of the CFD solvers and the domain-connectivity module are orchestrated by a Python-based computational infrastructure. The domain-connectivity module is fully parallel and performs all its operations (identification of grid overlaps and determination of data interpolation strategy) on the partitioned grid data. In addition, the domain connectivity procedures are completely automated such that no user intervention or manual input is necessary. The capabilities and performance of the package are presented for several test problems, including flow over a NACA 0015 wing and an AGARD A2 slotted airfoil, hover simulation of a scaled V-22 rotor, and dynamic simulation of a UH-60A rotor in forward flight. A modification to the algorithm for improved domain connectivity solutions in problems with tight tolerances as well as heterogeneous grid clustering is also presented. Published by Elsevier Inc. C1 [Sitaraman, Jayanarayanan] Univ Wyoming, Laramie, WY 82071 USA. [Floros, Matthew] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Wissink, Andrew; Potsdam, Mark] Army Aeroflightdynam Directorate, Moffett Field, CA USA. RP Sitaraman, J (reprint author), Univ Wyoming, Laramie, WY 82071 USA. EM jsitaram@uwyo.edu; matt.floros@us.army.mil; awissink@us.army.mil; mpotsdam@us.army.mil RI Larsson, Johan/B-9543-2017 OI Larsson, Johan/0000-0001-8387-1933 FU Department of Defense High Performance Computing Modernization Office (HPCMO) FX Development was performed at the HPC Institute for Advanced Rotorcraft Modeling and Simulation (HIARMS) located at the US Army Aeroflightdynamics Directorate at Moffett Field, CA, which is supported by the Department of Defense High Performance Computing Modernization Office (HPCMO). The authors would like to acknowledge Dr. Robert Meakin for many of the original ideas and critical concepts that have been used in the development of the domain-connectivity module. We also gratefully acknowledge the contributions of Dr. Venke Sankaran in reviewing the manuscript, Dr. Willam Chan for providing test cases and insights, Dr. Buvana Jayaraman for verifying the robustness of the simulation capability and Dr. Beatrice Roget for discussions on search algorithms. In addition, we are grateful to Dr. Thomas Pulliam for the development of the higher-order Cartesian-mesh solver (ARC3DC). We also thank Dr. Dimitri Mavriplis and Dr. Zhi Yang at the University of Wyoming for providing the NSU3D code. NR 32 TC 19 Z9 19 U1 1 U2 12 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD JUN 20 PY 2010 VL 229 IS 12 BP 4703 EP 4723 DI 10.1016/j.jcp.2010.03.008 PG 21 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 599WJ UT WOS:000277944400015 ER PT J AU Shackelford, SA Belletire, JL Boatz, JA Schneider, S Wheaton, AK Wight, BA Ammon, HL Peryshkov, DV Strauss, SH AF Shackelford, Scott A. Belletire, John L. Boatz, Jerry A. Schneider, Stefan Wheaton, Amanda K. Wight, Brett A. Ammon, Herman L. Peryshkov, Dmitry V. Strauss, Steven H. TI Bridged Heterocyclium Dicationic closo-Icosahedral Perfluoroborane, Borane, and Carborane Salts via Aqueous, Open-Air Benchtop Synthesis SO ORGANIC LETTERS LA English DT Article AB Thirteen bridged triazolium and imidazolium dicationic salts, which uniquely pair closo-icosahedral perfluoroborane [B(12)F(12)](2-), borane [B(12)H(12)](2-), or carborane [CB(11)H(12)](-) anionic species with unsaturated bridged heterocyclium dications, were synthesized using an aqueous benchtop method. This considerably extends the scope of a reported aqueous synthesis of binary [heterocyclium](2)[B(12)H(12)] and [heterocyclium][CB(11)H(12)] salts. Also, the one-step preparation of five new precursor bridged heterocyclium dicationic dihalide salts using conventional procedures and in one case a microwave-assisted method Is described. C1 [Ammon, Herman L.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Peryshkov, Dmitry V.; Strauss, Steven H.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. [Belletire, John L.; Wheaton, Amanda K.; Wight, Brett A.] USA, Res Lab, Propellants Branch AFRL RZSP, ERC Inc, Edwards AFB, CA 93524 USA. EM scott.shackelford@edwards.af.mil RI Peryshkov, Dmitry/B-8706-2008; OI Peryshkov, Dmitry/0000-0002-5653-9502 FU AFRL/RZ; AFB, OH; AFRL/RZS, Edwards AFB, CA; ERC, Inc., Huntsville, AL FX AFRL/RZ Chief Scientist, Dr. Alan Garscadden, Wright-Patterson AFB, OH, entrepreneurial research funds. AFRL/RZS, Edwards AFB, CA, funding, Dr. Robert Corley and Mr. Shaun Raquedan, technical and logistics support. ERC, Inc., Huntsville, AL, for CSU financial assistance. NR 16 TC 8 Z9 11 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1523-7060 J9 ORG LETT JI Org. Lett. PD JUN 18 PY 2010 VL 12 IS 12 BP 2714 EP 2717 DI 10.1021/ol100752y PG 4 WC Chemistry, Organic SC Chemistry GA 608WN UT WOS:000278616800010 PM 20499850 ER PT J AU Shukla, MK Dubey, M Zakar, E Namburu, R Leszczynski, J AF Shukla, Manoj K. Dubey, Madan Zakar, Eugene Namburu, Raju Leszczynski, Jerzy TI Interaction of nucleic acid bases and Watson-Crick base pairs with fullerene: Computational study SO CHEMICAL PHYSICS LETTERS LA English DT Article ID GOLD NANOPARTICLES; C-60; CARBON; CYTOTOXICITY; NUCLEOSIDES; CLUSTERS; CANCER; CELLS AB A first-principle investigation using the recently developed M05-2X density functional and the 6-311++G(d, p) basis set was performed to understand the nature of interaction between C(60) and nucleic acid bases and the Watson-Crick base pairs. It was found that C(60) forms stacking complexes with nucleic acid bases and base pairs. It was revealed that the strength of interaction of nucleic acid bases with C(60) follows the order: G > C > A > T > U, while the GC base pair forms stronger complex than the AT base pair with C(60). (C) 2010 Elsevier B. V. All rights reserved. C1 [Shukla, Manoj K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Dubey, Madan; Zakar, Eugene] USA, Sensor & Elect Devices Directorate, Res Lab, Adelphi, MD 20783 USA. [Namburu, Raju] USA, Computat & Informat Sci Directorate, Res Lab, Adelphi, MD 20783 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. EM jerzy@icnanotox.org FU Army Research Laboratory [W911QX-07-C-0100, CNMS2009-031]; NSF-CREST [HRD-0 833 178]; NSF EPSCoR [362 492-190 200-01\NSFEPS-0 903 787] FX MKS and JL are thankful to supports from Army Research Laboratory Contract No. W911QX-07-C-0100, CNMS2009-031, NSF-CREST Grant No. HRD-0 833 178 and NSF EPSCoR Grant No. 362 492-190 200-01\NSFEPS-0 903 787. Authors are also thankful to ARL, Computational and Information Sciences Directorate Adelphi, MD 20 783, and Mississippi Center for Supercomputing Research (MCSR) for providing computational facilities. NR 27 TC 10 Z9 10 U1 1 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JUN 17 PY 2010 VL 493 IS 1-3 BP 130 EP 134 DI 10.1016/j.cplett.2010.05.032 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 608OA UT WOS:000278592400026 ER PT J AU Miller, BF DeYoung, RW Campbell, TA Laseter, BR Ford, WM Miller, KV AF Miller, Brad F. DeYoung, Randy W. Campbell, Tyler A. Laseter, Benjamin R. Ford, W. Mark Miller, Karl V. TI Fine-scale genetic and social structuring in a central Appalachian white-tailed deer herd SO JOURNAL OF MAMMALOGY LA English DT Article DE female philopatry; genetic structure; Odocoileus virginianus; relatedness; social groups; spatial autocorreladon; white-tailed deer ID SPATIAL AUTOCORRELATION; NORTHEASTERN MINNESOTA; ADIRONDACK MOUNTAINS; LOCALIZED MANAGEMENT; POPULATION-GENETICS; FEMALE PHILOPATRY; WILDLIFE ECOLOGY; MATING SYSTEMS; RED DEER; DISPERSAL AB Spatial genetic structure in white-tailed deer (Odocoileus virginianus) has been examined at regional scales, but genetic markers with the resolution to detect fine-scale patterns have appeared only recently. We used a panel of microsatellite DNA markers, radiotelemetry data, and visual observations of marked deer to study fine-scale social and genetic structure in a high-density population of white-tailed deer (12-20 deer/km(2)). We collected genetic data on 229 adult females, 102 of which were assigned to 28 social groups. Our results were consistent with the conceptual model of white-tailed deer social structure, where philopatric females form social groups composed of related individuals. Within-group relatedness values approached the expected value for 1st cousins (R = 0.103, SE = 0.033), but individuals among groups (R = 0.014, SE = 0.003) and overall (R = -0.009, SE = 0.003) were unrelated. Fixation indices revealed a significant departure from equilibrium values among social groups (F(ST) = 0.076, SE = 0.007) and an excess of heterozygotes within groups (F(ls) = 0.050, SE = 0.018), consistent with theoretical expectations for mammal populations characterized by female philopatry and a polygynous mating system. Analyses of spatial autocorrelation indicated genetic structuring occurred at a very fine spatial scale, where pairs of adult females within 1 km were genetically nonindependent. The occurrence of fine-scale genetic and social structure has implications for the ecology and management of white-tailed deer, including habitat use and resource competition, offspring sex allocation theories, disease transmission, and the consideration of social behaviors in management. DOI: 10.1644/09-MAMM-A-258.1. C1 [DeYoung, Randy W.] Texas A&M Univ, Caesar Kleberg Wildlife Res Inst, Kingsville, TX 78363 USA. [Miller, Brad F.; Laseter, Benjamin R.; Miller, Karl V.] Univ Georgia, Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. [Campbell, Tyler A.] Texas A&M Univ, Natl Wildlife Res Ctr, Anim & Plant Hlth Inspect Serv, USDA,Wildife Serv,Texas Field Stn, Kingsville, TX 78363 USA. [Ford, W. Mark] USA, Engineer Res & Dev Ctr, Environm Lab, Ecol Resources Branch, Vicksburg, MS 39180 USA. RP DeYoung, RW (reprint author), Texas A&M Univ, Caesar Kleberg Wildlife Res Inst, MSC 218, Kingsville, TX 78363 USA. EM randall.deyoung@tamuk.edu FU Mead Westvaco Corporation; West Virginia Division of Natural Resources; United States Department of Agriculture National Research [00-35101-9284, 03-35101-13719] FX Financial assistance was provided by the Mead Westvaco Corporation, the West Virginia Division of Natural Resources, and the United States Department of Agriculture National Research Initiative Competitive Grants Program (grants 00-35101-9284 and 03-35101-13719). We thank B. Faircloth for laboratory assistance, and J. L. Crum, P. D. Keyser, and D. A. Osborn for logistical assistance. We also thank the numerous field technicians and volunteers that helped with sample collections. The comments of J. P. Carroll, C. J. Nairn, and R. J. Warren improved early versions of this manuscript. All animal-handling procedures were approved by The University of Georgia Institutional Animal Care and Use Committee (permit A2002-10119-0). Deer were captured and handled under scientific collection permits from the West Virginia Division of Natural Resources. NR 65 TC 19 Z9 19 U1 1 U2 23 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 0022-2372 J9 J MAMMAL JI J. Mammal. PD JUN 16 PY 2010 VL 91 IS 3 BP 681 EP 689 DI 10.1644/09-MAMM-A-258.1 PG 9 WC Zoology SC Zoology GA 615JG UT WOS:000279130300016 ER PT J AU Moore, JD Palmer, JC Liu, YC Roussel, TJ Brennan, JK Gubbins, KE AF Moore, Joshua D. Palmer, Jeremy C. Liu, Ying-Chun Roussel, Thomas J. Brennan, John K. Gubbins, Keith E. TI Adsorption and diffusion of argon confined in ordered and disordered microporous carbons SO APPLIED SURFACE SCIENCE LA English DT Article; Proceedings Paper CT 7th International Symposium on Effects of Surface Heterogeneity in Adsorption and Catalysis on Solids CY JUL 05-11, 2009 CL Kazimierz Dolny, POLAND DE Adsorption; Diffusion; Activated carbon; Carbon replica; Faujasite ID SINGLE-FILE DIFFUSION; REVERSE MONTE-CARLO; MOLECULAR-DYNAMICS SIMULATION; NARROW CYLINDRICAL PORES; SELF-DIFFUSION; POROUS CARBONS; ACTIVATED CARBONS; FLUIDS; MODELS; DEPENDENCE AB We use a combination of grand canonical Monte Carlo and microcanonical molecular dynamics simulations to study the adsorption and diffusion of argon at 77 K and 120 K confined in previously generated models of a disordered bituminous coal-based carbon, BPL, and an ordered carbon replica of Faujasite zeolite (C-FAU). Both materials exhibit a maximum in the diffusion coefficient as well as anomalous (sub-diffusive) behavior in the mean-squared displacements at short times at some relative pressures. In BPL, the anomalous diffusion occurs at low relative pressures, due to the trapping of argon atoms in small pores. In C-FAU, the anomalous diffusion occurs at high relative pressures, due to competitive diffusion of atoms traveling through windows and constrictions which interconnect the pores. All diffusion eventually tends to Fickian diffusion at longer times. (C) 2009 Elsevier B.V. All rights reserved. C1 [Moore, Joshua D.; Palmer, Jeremy C.; Liu, Ying-Chun; Gubbins, Keith E.] N Carolina State Univ, Inst Computat Sci & Engn, Raleigh, NC 27695 USA. [Moore, Joshua D.; Palmer, Jeremy C.; Liu, Ying-Chun; Gubbins, Keith E.] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA. [Liu, Ying-Chun] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China. [Roussel, Thomas J.] CSIC, Inst Ciencia Mat, Barcelona 08193, Spain. [Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gubbins, KE (reprint author), N Carolina State Univ, Inst Computat Sci & Engn, Raleigh, NC 27695 USA. EM keg@ncsu.edu RI Roussel, Thomas/K-8780-2014 OI Roussel, Thomas/0000-0001-6004-3668 NR 37 TC 31 Z9 32 U1 0 U2 21 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD JUN 15 PY 2010 VL 256 IS 17 BP 5131 EP 5136 DI 10.1016/j.apsusc.2009.12.071 PG 6 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA 597BW UT WOS:000277731800002 ER PT J AU Luo, YT Guo, JC Wang, CS Chu, D AF Luo, Yanting Guo, Juchen Wang, Chunsheng Chu, Deryn TI Quaternized poly(methyl methacrylate-co-butyl acrylate-co-vinylbenzyl chloride) membrane for alkaline fuel cells SO JOURNAL OF POWER SOURCES LA English DT Article DE Alkaline fuel cells; Anion conductive membrane; Copolymerization; Ionic conductivity ID ANION-EXCHANGE MEMBRANE; SOLID POLYMER ELECTROLYTE; SECONDARY BATTERIES; ELECTROCHEMICAL PROPERTIES; COMPOSITE MEMBRANES; METHANOL; PERFORMANCE; AMFCS AB Instead of modification of pre-existing polymers, a new route of preparation of polyelectrolyte OH(-) conductive membranes via copolymerization of selected functional monomers was reported in this study. A random copolymer of poly(methyl methacrylate-co-butyl acrylate-co-vinylbenzyl chloride) was synthesized via copolymerization, which was followed by quaternization and membrane casting. The intrinsic OH- conductivity of the free-standing polyelectrolyte membranes can reach 8.2 x 10(-3) S cm(-1) at 80 degrees C. The alkaline fuel cells using copolymer polyelectrolytes demonstrated the feasibility of the preparation concept of these membranes. (C) 2010 Elsevier B.V. All rights reserved. C1 [Luo, Yanting; Guo, Juchen; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Chu, Deryn] USA, Sensors & Electron Device Directorate, Res Lab, Adelphi, MD 20783 USA. RP Wang, CS (reprint author), Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. EM cswang@umd.edu RI Wang, Chunsheng/H-5767-2011 OI Wang, Chunsheng/0000-0002-8626-6381 FU Office of Naval Research [N000140810717]; Army Research Lab [W911NF0920007]; Army Research Office [W911NF0910028] FX The authors gratefully acknowledge the supports of this project by Office of Naval Research (N000140810717), Army Research Lab (W911NF0920007), and Army Research Office (W911NF0910028). NR 42 TC 67 Z9 70 U1 3 U2 41 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUN 15 PY 2010 VL 195 IS 12 SI SI BP 3765 EP 3771 DI 10.1016/j.jpowsour.2009.12.106 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 568EH UT WOS:000275504500001 ER PT J AU Villines, TC Stanek, EJ Devine, PJ Turco, M Miller, M Weissman, NJ Griffen, L Taylor, AJ AF Villines, Todd C. Stanek, Eric J. Devine, Patrick J. Turco, Mark Miller, Michael Weissman, Neil J. Griffen, Len Taylor, Allen J. TI The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis) Final Results and the Impact of Medication Adherence, Dose, and Treatment Duration SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article DE atherosclerosis; risk factors; lipids ID INTIMA-MEDIA THICKNESS; EXTENDED-RELEASE NIACIN; COMBINATION; PROGRESSION; PREVENTION; EFFICACY; THERAPY; STATINS; DISEASE AB Objectives This report describes the final results of the ARBITER 6-HALTS (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis) trial. Background The ARBITER 6-HALTS trial was terminated early on the basis of a pre-specified interim analysis showing superiority of niacin over ezetimibe on change in carotid intima-media thickness (CIMT). After termination, an additional 107 subjects completed a close-out assessment. Methods Patients with coronary heart disease (CHD) or CHD equivalent with low-density lipoprotein cholesterol <100 mg/dl and high-density lipoprotein cholesterol <50 mg/dl for men or 55 mg/dl for women while receiving stable statin treatment were randomly assigned to ezetimibe (10 mg/day) or extended-release niacin (target dose, 2,000 mg/day). The primary end point was change in mean CIMT, analyzed according to a last observation carried forward method. The relationships of study medication adherence, dosage, and cumulative exposure (product of adherence, dose, and time) with change in CIMT were explored. Results Results in 315 patients included 208 with 14-month follow-up and 107 after mean treatment of 7 +/- 3 months. Niacin (n = 154) resulted in significant reduction (regression) in mean CIMT (-0.0102 +/- 0.0026 mm; p < 0.001) and maximal CIMT (-0.0124 +/- 0.0036 mm; p = 0.001), whereas ezetimibe (n = 161) did not reduce mean CIMT (-0.0016 +/- 0.0024 mm; p = 0.88) or maximal CIMT (-0.0005 +/- 0.0029 mm; p = 0.88) compared with baseline. There was a significant difference between ezetimibe and niacin treatment groups on mean changes in CIMT, favoring niacin, for both mean CIMT (p = 0.016) and maximal CIMT (p = 0.01). Increased cumulative drug exposure was related to regression of CIMT with niacin, and progression of CIMT with ezetimibe. Conclusions Niacin induces regression of CIMT and is superior to ezetimibe for patients taking statins. (Comparative Study of the Effect of Ezetimibe Versus Extended-Release Niacin on Atherosclerosis; NCT00397657) (J Am Coll Cardiol 2010;55:2721-6) (C) 2010 by the American College of Cardiology Foundation C1 [Villines, Todd C.; Devine, Patrick J.; Taylor, Allen J.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Stanek, Eric J.] Medco Hlth Solut, Franklin Lakes, NJ USA. [Turco, Mark] Washington Adventist Hosp, Takoma Pk, MD USA. [Miller, Michael] Univ Maryland, Med Ctr, Baltimore, MD 21201 USA. [Weissman, Neil J.; Taylor, Allen J.] Washington Hosp Ctr, Medstar Res Inst, Washington, DC 20010 USA. [Griffen, Len] Cardiac Associates, Rockville, MD USA. RP Villines, TC (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A-34A, Washington, DC 20307 USA. EM todd.villines@amedd.army.mil FU Abbott Pharmaceuticals; Abbott Cardiovascular FX Abbott Pharmaceuticals funded the study by an unrestricted, investigator-initiated research grant administered by the Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland. Dr. Villines has received lecture honoraria from Novartis Pharmaceuticals. Dr. Stanek is an employee, with significant equity holdings, of Medco Health Solutions Inc. Dr. Miller has received speaking honoraria from Merck. Dr. Turco received consulting fees and lecture honoraria from Abbott Cardiovascular. Dr. Taylor receives lecture honoraria from Abbott that are donated to charity. The opinions or assertions herein are the private views of the authors and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense. NR 14 TC 141 Z9 147 U1 6 U2 16 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 EI 1558-3597 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD JUN 15 PY 2010 VL 55 IS 24 BP 2721 EP 2726 DI 10.1016/j.jacc.2010.03.017 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 608EJ UT WOS:000278565200004 PM 20399059 ER PT J AU Darling, KA VanLeeuwen, BK Koch, CC Scattergood, RO AF Darling, K. A. VanLeeuwen, B. K. Koch, C. C. Scattergood, R. O. TI Thermal stability of nanocrystalline Fe-Zr alloys SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Mechanical alloying; Nanostructured materials; Grain growth ID GRAIN-GROWTH; SOLUTE SEGREGATION; SIZE; STABILIZATION; NANOSTRUCTURES; TIO2; TEM; NI AB Fe-Zr nanocrystalline alloys with an as-milled grain size less than 10 nm were synthesized by ball milling. The microstructure changes due to annealing were characterized using X-ray line broadening, microhardness, focused ion beam channeling contrast imaging, and transmission electron microscopy (TEM). Additions of 1/3 to 4 at.% Zr stabilized nanocrystalline grain sizes at elevated annealing temperatures compared to pure Fe. With 4 at.% Zr, a fully nanocrystalline microstructure with a TEM grain size of 52 nm was retained at temperatures in excess of 900 degrees C. Alloys with lower Zr contents showed less stability, but still significant compared to pure Fe. Bimodal nano-micro grain size microstructures were also observed. (c) 2010 Elsevier B.V. All rights reserved. C1 [VanLeeuwen, B. K.; Koch, C. C.; Scattergood, R. O.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Darling, K. A.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA. RP Scattergood, RO (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, 911 Partners Way,Room 3000, Raleigh, NC 27695 USA. EM kris.darling@arl.army.mil; bkvanlee@ncsu.edu; carl_koch@ncsu.edu; scatterg@ncsu.edu FU National Science Foundation [0504286] FX The authors are indebted to the National Science Foundation for support of this research work (DMR Grant no. 0504286). The authors thank Ryan Chan and Jonathon Semones for assistance with the experimental work and discussion on the results. NR 40 TC 62 Z9 64 U1 4 U2 42 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JUN 15 PY 2010 VL 527 IS 15 BP 3572 EP 3580 DI 10.1016/j.msea.2010.02.043 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 597LF UT WOS:000277758000040 ER PT J AU Hurst, FP Sajjad, I Elster, EA Falta, EM Patel, P Abbott, KC Agodoa, LY Jindal, RM AF Hurst, Frank P. Sajjad, Imran Elster, Eric A. Falta, Edward M. Patel, Prem Abbott, Kevin C. Agodoa, Lawrence Y. Jindal, Rahul M. TI Transplantation of A2 Kidneys into B and O Recipients Leads to Reduction in Waiting Time: USRDS Experience SO TRANSPLANTATION LA English DT Article DE Waiting time; Kidney transplant; A2 blood group kidneys ID A(2) KIDNEYS; ABO; DONORS; SURVIVAL AB Introduction. Strategy of transplanting kidneys from A2 donors into patients with blood group B and O recipients has been used to alleviate the long waiting times. Materials and Methods. We used an inception cohort of US Renal Data System data base with patients older than 18 years who underwent renal transplantation between January 1995 and July 2006. The primary outcome variable was allograft loss (including death). Bivariate analysis of factors associated with receiving A2 or A2B kidneys was performed with chi-square testing for categorical variables (Fisher's exact test used for violations of Cochran's assumptions) and Student's t test for continuous variables (Mann-Whitney U test used for nonnormally distributed variables). Results. There were 150,118 first kidney transplants of whom 113 received kidney transplant from A2 to O, and 125 patients received A2 to B kidney transplant. Compared with other recipients from the same blood group, recipients of A2 kidneys had significantly shorter wait times. O recipients had a median wait time of 1.63 years (range 0.00-17.21 years), whereas O recipients who received A2 kidneys had a median wait time of 0.70 years (range 0.02-1.47 years; P < 0.001). B recipients had a median wait time of 1.90 years (range 0.00-17.52 years), whereas B recipients who received A2 kidneys had a median wait time of 0.74 years (range 0.10-5.21 years; P < 0.001). There was no significant difference in graft loss or death between A2 to O and B versus all other recipients. Conclusions. The results showed that comparatively few patients received A2 to B or O kidney transplant. C1 [Hurst, Frank P.; Elster, Eric A.; Falta, Edward M.; Abbott, Kevin C.; Jindal, Rahul M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Sajjad, Imran] Univ Wisconsin, Dept Med, Madison, WI 53706 USA. [Elster, Eric A.; Falta, Edward M.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Patel, Prem] Bookdale Univ Hosp & Med Ctr, Brooklyn, NY USA. [Agodoa, Lawrence Y.] NIDDK, Dept Surg, NIH, Bethesda, MD USA. [Jindal, Rahul M.] George Washington Univ, Dept Med, Washington, DC USA. [Hurst, Frank P.; Abbott, Kevin C.] Walter Reed Army Med Ctr, Dept Nephrol, Washington, DC 20307 USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Dept Organ Transplant, 6630 Georgia Ave, Washington, DC 20307 USA. EM jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 NR 20 TC 8 Z9 8 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD JUN 15 PY 2010 VL 89 IS 11 BP 1396 EP 1402 DI 10.1097/TP.0b013e3181da191a PG 7 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA 605IE UT WOS:000278340400016 PM 20354481 ER PT J AU Chang, TW Blank, M Janardhanan, P Singh, BR Mello, C Blind, M Cai, SW AF Chang, Tzuu-Wang Blank, Michael Janardhanan, Pavithra Singh, Bal Ram Mello, Charlene Blind, Michael Cai, Shuowei TI In vitro selection of RNA aptamers that inhibit the activity of type A botulinum neurotoxin SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE RNA; Aptamer; Botulinum neurotoxin; Antidote; Endopeptidase ID WEB SERVER; LIGHT-CHAIN; SEROTYPE; PREDICTION; TOXIN; METALLOPROTEASE; PHARMACOPHORE; MECHANISMS; MOLECULES; CHANNELS AB The category A agent, botulinum neurotoxin (BoNT), is the most toxic molecule known to mankind. The endopeptidase activity of light chain domain of BoNT is the cause for the inhibition of the neurotransmitter release and the flaccid paralysis that leads to lethality in botulism. Currently, antidotes are not available to reverse the flaccid paralysis caused by BoNT. In the present study, we have identified three RNA aptamers through SELEX-process, which bind strongly to the light chain of type A BoNT (BoNT/A) and inhibit the endopeptidase activity, with IC(50) in low nM range. Inhibition kinetic studies reveal low nM K(1) and non-competitive nature of their inhibition. Aptamers are unique group of molecules as therapeutics, and this is first report of their development as an antidote against botulism. These data on K(1) and IC(50) strongly suggest that the aptamers have strong potential as antidotes that can reverse the symptom caused by BoNT/A. (c) 2010 Elsevier Inc. All rights reserved. C1 [Chang, Tzuu-Wang; Janardhanan, Pavithra; Singh, Bal Ram; Cai, Shuowei] Univ Massachusetts Dartmouth, Dept Chem & Biochem, N Dartmouth, MA 02747 USA. [Chang, Tzuu-Wang; Janardhanan, Pavithra; Singh, Bal Ram; Cai, Shuowei] Univ Massachusetts Dartmouth, Botulinum Res Ctr, N Dartmouth, MA 02747 USA. [Blank, Michael] German Res Ctr Hlth & Environm GmbH, Helmholtz Zentrum Munchen, Inst Mol Immunol, D-81377 Munich, Germany. [Mello, Charlene] USA, Natick Soldier RD&E Ctr, Washington, DC USA. [Blind, Michael] NascaCell Technol AG, Munich, Germany. RP Cai, SW (reprint author), Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA. EM scai@umassd.edu FU NIH [5R21AI070787-02]; U.S. Army Natick Soldier Research, Development and Engineering Center FX This work was supported by the NIH grant 5R21AI070787-02. CM was partially supported by the U.S. Army Natick Soldier Research, Development and Engineering Center's basic research program. NR 26 TC 20 Z9 21 U1 1 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD JUN 11 PY 2010 VL 396 IS 4 BP 854 EP 860 DI 10.1016/j.bbrc.2010.05.006 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 615HJ UT WOS:000279125100013 PM 20452328 ER PT J AU Wang, XY Stavchansky, S Kerwin, SM Bowman, PD AF Wang, Xinyu Stavchansky, Salomon Kerwin, Sean M. Bowman, Phillip D. TI Structure-activity relationships in the cytoprotective effect of caffeic acid phenethyl ester (CAPE) and fluorinated derivatives: Effects on heme oxygenase-1 induction and antioxidant activities SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE Caffeic acid phenethyl ester; Fluorinated derivative; Cytoprotection; Oxidative stress; Human endothelial cell; Heme oxygenase-1; Structure-activity relationship ID HUMAN ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SULFHYDRYL-GROUPS; PROTECT; KEAP1; ISCHEMIA/REPERFUSION; CYTOTOXICITY; POLYPHENOL; METABOLISM; EXPRESSION AB To determine the relationship between catechol ring modifications and the activity of caffeic acid phenethyl ester (CAPE) as a cytoprotective agent, six catechol ring-fluorinated CAPE derivatives were evaluated for their cytoprotective abilities, as well as for their antioxidant and heme oxygenase-1 (HO-1) inducing capacity in a human umbilical vein endothelial cell (HUVEC) model of oxidant stress. To ascertain the involvement of HO-1 induction in the cytoprotective effects of CAPE analogues, their ability to induce HO-1 at 20 mu M was determined by reverse transcriptase polymerase chain reaction, western blotting and the use of HO-1 inhibitor tin protoporphyrin IX. There was significant induction of HO-1 by CAPE derivatives. Inhibition of HO-1 enzymatic activity resulted in reduced cytoprotection. Modification of the catechol ring of CAPE by introduction of fluorine at various positions resulted in dramatic changes in cytoprotective activity. The maintenance of at least one hydroxyl group on the CAPE catechol ring and the phenethyl ester portion was required for HO-1 induction. CAPE and its derivatives were screened for their ability to scavenge intracellular reactive oxygen species generated in HUVECs by measuring 5-(and-6)-chlormethyl-2', 7'-dichlorodihydro-fluorescein diacetate oxidation. The maintenance of 3, 4-dihydroxyl groups on the catechol ring was required for antioxidant activity, but antioxidant activity did not guarantee cytoprotection. Methylation or replacement of one hydroxyl group on the catechol ring of CAPE, however, provided both pro-oxidant and cytoprotective activities. These results indicate that the induction of HO-1 plays a more important role in the cytoprotective activity of CAPE derivatives than their direct antioxidant activity. (C) 2010 Published by Elsevier B.V. C1 [Wang, Xinyu; Stavchansky, Salomon] Univ Texas Austin, Div Pharmaceut, Coll Pharm, Austin, TX 78712 USA. [Wang, Xinyu; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. [Kerwin, Sean M.] Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. RP Bowman, PD (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM phillip.bowman@amedd.army.mil OI Kerwin, Sean/0000-0001-8432-6558 NR 33 TC 25 Z9 27 U1 3 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD JUN 10 PY 2010 VL 635 IS 1-3 BP 16 EP 22 DI 10.1016/j.ejphar.2010.02.034 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 602ZR UT WOS:000278178200003 PM 20226179 ER PT J AU Ramsay, LB Stany, MP Edison, JD Bernstein, SA Schlegal, KE Hamilton, CA AF Ramsay, Laura B. Stany, Michael P. Edison, Jess D. Bernstein, Sarah A. Schlegal, Kevin E. Hamilton, Chad A. TI Gemcitabine-Associated Large Vessel Vasculitis Presenting as Fever of Unknown Origin SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY LA English DT Article DE gemcitabine; vasculitis; fever of unknown origin ID SAFETY PROFILE; THERAPY; CANCER; PET AB Gemcitabine is a nucleoside analogue used for treatment of multiple cancers. Recent reports describe small to medium vessel vasculitis as a rare complication of therapy. We report a case of significant large vessel vasculitis presenting as fever of unknown origin in a patient treated adjuvantly with docetaxel and gemcitabine for uterine leiomyosarcoma. The patient presented after her first and second exposure to chemotherapy with fever of unknown origin and worsening subsequent chest and neck discomfort. Extensive workup revealed radiographic and laboratory evidence of aortic vasculitis. We initiated treatment with high-dose corticosteroids, and the patient's condition resolved without complication over the next several weeks. To our knowledge, this represents the first case of gemcitabine-induced large vessel vasculitis which presented in our case as fever of unknown origin. Awareness of this potential complication is essential as discontinuing the inciting drug and initiating corticosteroid treatment can be life-saving. C1 [Ramsay, Laura B.; Stany, Michael P.; Bernstein, Sarah A.; Hamilton, Chad A.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Washington, DC 20307 USA. [Edison, Jess D.] Walter Reed Army Med Ctr, Dept Rheumatol, Washington, DC 20307 USA. [Schlegal, Kevin E.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Stany, MP (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM micheal.stany@us.army.mil NR 15 TC 6 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1076-1608 J9 JCR-J CLIN RHEUMATOL JI JCR-J. Clin. Rheumatol. PD JUN 10 PY 2010 VL 16 IS 4 BP 181 EP 182 DI 10.1097/RHU.0b013e3181df91ad PG 2 WC Rheumatology SC Rheumatology GA 602SP UT WOS:000278159400009 PM 20407388 ER PT J AU Mallick, G Griep, MH Ajayan, PM Karna, SP AF Mallick, Govind Griep, Mark H. Ajayan, Pulickel M. Karna, Shashi P. TI Alternating current-to-direct current power conversion by single-wall carbon nanotube diodes SO APPLIED PHYSICS LETTERS LA English DT Article ID RECTIFIER; DESIGN AB We report the observation of alternating current-to-direct current half-wave conversion in the range of 1-1000 Hz by single-wall carbon nanotube diode rectifiers, which show a high degree of rectification (similar to 10(5)). The nanoscale diode rectifier demonstrates a half-wave power conversion efficiency of 20%, which is comparable to that reported for larger metal oxide semiconductor field effect transistor diode designs. (C) 2010 American Institute of Physics. [doi:10.1063/1.3429587] C1 [Mallick, Govind; Griep, Mark H.; Karna, Shashi P.] USA, Dept Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Ajayan, Pulickel M.] Rice Univ, Dept Mech Engn & Mat Sci, Houston, TX 77005 USA. RP Mallick, G (reprint author), USA, Dept Army, Res Lab, Weap & Mat Res Directorate, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM shashi.karna@us.army.mil FU U.S. Army Research Laboratory [ARL-DRI-07-WMR-10, ARL-DRI-08-WMR-20]; Rice faculty FX All the authors listed have equally contributed to this research. This research was supported by the U.S. Army Research Laboratory, Director's Research Initiatives, Grant Nos. ARL-DRI-07-WMR-10 and ARL-DRI-08-WMR-20. P.M.A. acknowledges support from Rice faculty startup funding. We thank Sarah Lastella and Sangeeta Sahoo for help with the SWCNT growth and Gary Hirsch for SEM micrographs. NR 22 TC 1 Z9 1 U1 1 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 7 PY 2010 VL 96 IS 23 AR 233109 DI 10.1063/1.3429587 PG 3 WC Physics, Applied SC Physics GA 609YX UT WOS:000278695900066 ER PT J AU Campbell, NP Finch, AS Rokita, SE AF Campbell, Neil P. Finch, Amethist S. Rokita, Steven E. TI Modulating the Ground- and Excited-State Oxidation Potentials of Diaminonaphthalene by Sequential N-Methylation SO CHEMPHYSCHEM LA English DT Article DE diaminonaphthalenes; electron transfer; excited-state electron donor; fluorescence; voltammetry ID DUPLEX DNA; THYMINE DIMER; SELF-REPAIR; ELECTRON; NANOSTRUCTURES; TRANSPORT; KINETICS; DESIGN; AMINES AB A series of 1,5-diaminonaphthalene derivatives were synthesized and characterized to provide ground- and excited-state electron donors of similar structure but varying potential. Electrochemical and spectroscopic properties of the series are reported and together illustrate two opposing consequences of alkyl substitution on the aryl amines. Inductive effects of methylation are evident from the decrease in ground-state oxidation potential for derivatives containing monomethylamino substituents. In contrast, steric effects seem to dominate the increase in the ground-state oxidation potential of derivatives containing dimethylamino substituents since the conformational constraints created by dimethylation suppress delocalization of the nonbonding electrons. Absorption and emission properties also respond to increasing levels of N-methylation, and the excited-state oxidation potentials of the parent 1,5-diaminonaphthalene and its monomethylamine derivatives (ca. -3.2 V) are approximately 200 mV lower than the corresponding dimethylamino derivatives (-3.0 V). C1 [Campbell, Neil P.; Rokita, Steven E.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Finch, Amethist S.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Rokita, SE (reprint author), Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. EM Rokita@umd.edu RI Rokita, Steven/C-4793-2009; Finch, Amethist/H-9510-2013 OI Finch, Amethist/0000-0002-4650-6301 FU National Science Foundation [CHE-0517498]; American Chemical Society [PRF 41514-AC4]; Department of Defense FX This work was supported in part by the National Science Foundation (CHE-0517498), the Donors of the American Chemical Society Petroleum Research Fund (PRF 41514-AC4) and a SMART Fellowship from the Department of Defense (A.S.F.). We also thank Dr. James Sumner for his invaluable assistance with the AC voltammetry, and Dr. Lyle Isaacs for help with molecular mechanics. NR 34 TC 7 Z9 7 U1 0 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1439-4235 J9 CHEMPHYSCHEM JI ChemPhysChem PD JUN 7 PY 2010 VL 11 IS 8 BP 1768 EP 1773 DI 10.1002/cphc.200900969 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 614SI UT WOS:000279079600028 PM 20376874 ER PT J AU He, QF Xu, ZY Sadler, BM AF He, Qunfeng Xu, Zhengyuan Sadler, Brian M. TI Performance of short-range non-line-of-sight LED-based ultraviolet communication receivers SO OPTICS EXPRESS LA English DT Article ID MULTIPLYING AVALANCHE PHOTODIODES; LIGHT-EMITTING-DIODES; GAINS AB Utilizing an empirical path loss model proposed in the first paper of a two-part series, the bit error rate performance of short-range non-line-of-sight ultraviolet communication receivers is analyzed. Typical photodetector models and modulation formats are considered. Our results provide semi-analytical prediction of the achievable communication performance as a function of system and channel parameters, and serve as a basis for system design. (C)2010 Optical Society of America C1 [He, Qunfeng; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA. RP He, QF (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu FU United States Army Research Office (USARO) [W911NF-09-1-0293, W911NF-08-1-0163]; United States Army Research Laboratory (USARL) [DAAD19-01-2-0011] FX The authors extend thanks to the anonymous reviewers for their valuable suggestions and comments. This work was supported in part by the United States Army Research Office (USARO) under grants W911NF-09-1-0293 and W911NF-08-1-0163, and the United States Army Research Laboratory (USARL) under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 18 TC 36 Z9 41 U1 0 U2 7 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUN 7 PY 2010 VL 18 IS 12 BP 12226 EP 12238 DI 10.1364/OE.18.012226 PG 13 WC Optics SC Optics GA 607SU UT WOS:000278527700022 PM 20588347 ER PT J AU Pan, YL Hill, SC Pinnick, RG Huang, H Bottiger, JR Chang, RK AF Pan, Yong-Le Hill, Steven C. Pinnick, Ronald G. Huang, Hermes Bottiger, Jerold R. Chang, Richard K. TI Fluorescence spectra of atmospheric aerosol particles measured using one or two excitation wavelengths: Comparison of classification schemes employing different emission and scattering results SO OPTICS EXPRESS LA English DT Article ID LASER-INDUCED FLUORESCENCE; AIRBORNE BIOLOGICAL PARTICLES; REAL-TIME MEASUREMENT; ORGANIC-CARBON; INTRINSIC FLUORESCENCE; ULTRAVIOLET-LASER; UV FLUORESCENCE; FINE AEROSOL; BIOAEROSOLS; ANALYZER AB An improved Dual-wavelength-excitation Particle Fluorescence Spectrometer (DPFS) has been reported. It measures two fluorescence spectra excited sequentially by lasers at 263 nm and 351 nm, from single atmospheric aerosol particles in the 1-10 mu m diameter size range. Here we investigate the different levels of discrimination capability obtained when different numbers of excitation and fluorescence-emission wavelengths are used for analysis. We a) use the DPFS to measure fluorescence spectra of Bacillus subtilis and other aerosol particles, and a 25-hour sample of atmospheric aerosol at an urban site in Maryland, USA; b) analyze the data using six different algorithms that employ different levels of detail of the measured data; and c) show that when more of the data measured by the DPFS is used, the ability to discriminate among particle types is significantly increased. (C) 2010 Optical Society of America C1 [Pan, Yong-Le; Hill, Steven C.; Pinnick, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA. [Huang, Hermes] Real Time Analyzers Inc, Middletown, CT 06457 USA. [Bottiger, Jerold R.] USA, Edgewood Chem & Biol Command, Aberdeen Proving Ground, MD 21010 USA. [Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA. RP Pan, YL (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM yongle.pan@us.army.mil FU Defense Threat Reduction Agency; US Army Research Laboratory FX This research was supported by the Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program, and by US Army Research Laboratory mission funds. NR 50 TC 39 Z9 41 U1 0 U2 23 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUN 7 PY 2010 VL 18 IS 12 BP 12436 EP 12457 DI 10.1364/OE.18.012436 PG 22 WC Optics SC Optics GA 607SU UT WOS:000278527700046 PM 20588371 ER PT J AU Hammond, RT AF Hammond, Richard T. TI Radiation reaction at ultrahigh intensities SO PHYSICAL REVIEW A LA English DT Article ID CLASSICAL CHARGED-PARTICLES; UNIFORM MAGNETIC-FIELD; REACTION FORCE; RELATIVISTIC MOTION; RUNAWAY SOLUTIONS; ELECTRODYNAMICS; ELECTRON; EQUATION; LASER; ENERGY AB Intensities of 10(22) W cm(-2) have been reached and it is expected that this will be increased by two orders of magnitude in the near future. At these intensities the radiation reaction force is important, especially in calculating the terminal velocity of an electron. The following briefly describes some of the problems of the existing most well-known equations and describes an approach based on conservation of energy. The resulting equation is compared to the Landau Lifshitz and Ford O'Connell equations, and laboratory tests are proposed. C1 [Hammond, Richard T.] Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. [Hammond, Richard T.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Hammond, RT (reprint author), Univ N Carolina, Dept Phys, Chapel Hill, NC 27515 USA. EM rhammond@email.unc.edu NR 41 TC 16 Z9 16 U1 0 U2 4 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUN 7 PY 2010 VL 81 IS 6 AR 062104 DI 10.1103/PhysRevA.81.062104 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 607DJ UT WOS:000278478600001 ER PT J AU Bokhari, H Smith, C Veerendra, K Sivaraman, J Sikaroodi, M Gillevet, P AF Bokhari, H. Smith, C. Veerendra, K. Sivaraman, J. Sikaroodi, M. Gillevet, P. TI Novel fluorescent protein from Hydnophora rigida possess cyano emission SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article DE Functional cloning; Cyano fluorescent protein; Coral; Hydnophora rigida; Prokaryotic expression ID AEQUOREA; ANTHOZOA; FAMILY AB Currently, a broad diversity of fluorescent proteins among marine organisms range from cyano-red emissions. Fluorescent proteins differ in their DNA sequences from green fluorescent protein (GFP). We identified cDNA encoding the gene of a new protein from the reef coral Hydnophora rigida of the Merulinidae family. Both the spectral properties and putative primary sequence of the protein has been determined. The cloned cDNA encode peptide we call HriCFP is comprised of 134 amino acids. It has characteristics of a cyano fluorescent protein (HriCFP) and its sequence is markedly different from known GFP from the hydroid jellyfish Aequorea victoria. HriCFP was cloned, expressed, purified and exist as monomer. The peptide mass finger print on the purified protein confirmed identity of HriCFP. (C) 2010 Elsevier Inc. All rights reserved. C1 [Smith, C.] USA, Engineer Res & Dev Ctr, Alexandria, VA USA. [Bokhari, H.; Sikaroodi, M.; Gillevet, P.] George Mason Univ, Dept Environm Sci & Policy, Microbiome Anal Ctr, Manassas, VA USA. [Veerendra, K.; Sivaraman, J.] Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore. RP Bokhari, H (reprint author), Comsats Inst Informat Technol, Dept Biosci, Chak Shazad Campus, Islamabad 44000, Pakistan. EM habib@comsats.edu.pk RI Sivaraman, J/H-8028-2012; bokhari, habib/J-1814-2015; Bokhari, Syed Habib/J-2825-2015 FU Higher Education Commission through National Research support program for Universities [760]; Academic Research Fund (ARF); National University of Singapore (NUS) [WBS: R154-000-438-112] FX The author H.B. thanks the COMSATS Institute of Information Technology, Islamabad: for encouragement and Higher Education Commission for support through National Research support program for Universities (Grant No. 760). The author J.S. acknowledges the research support from Academic Research Fund (ARF), National University of Singapore (NUS) (Grant No. WBS: R154-000-438-112). NR 16 TC 1 Z9 1 U1 1 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD JUN 4 PY 2010 VL 396 IS 3 BP 631 EP 636 DI 10.1016/j.bbrc.2010.04.136 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 610DG UT WOS:000278710200009 PM 20435020 ER PT J AU Ariyannur, PS Moffett, JR Manickam, P Pattabiraman, N Arun, P Nitta, A Nabeshima, T Madhavarao, CN Namboodiri, AMA AF Ariyannur, Prasanth S. Moffett, John R. Manickam, Pachiappan Pattabiraman, Nagarajan Arun, Peethambaran Nitta, Atsumi Nabeshima, Toshitaka Madhavarao, Chikkathur N. Namboodiri, Aryan M. A. TI Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: Implications for specialized acetyl coenzyme A metabolism in the CNS SO BRAIN RESEARCH LA English DT Article DE N-acetylaspartate; Aspartate N-acetyltransferase; Aspartoacylase; Gene expression; Homology modeling; Immunohistochemistry ID L-ASPARTIC ACID; N-ACETYLASPARTATE IMMUNOREACTIVITIES; MYELIN LIPID-SYNTHESIS; RAT-BRAIN; CANAVAN-DISEASE; NERVOUS-SYSTEM; DIFFERENTIAL DISTRIBUTION; SUBCELLULAR-LOCALIZATION; CEREBRAL HYPOMYELINATION; NEUROBLASTOMA-CELLS AB N-acetylaspartate (NAA) is a concentrated, neuron-specific brain metabolite routinely used as a magnetic resonance spectroscopy marker for brain injury and disease. Despite decades of research, the functional roles of NAA remain unclear. Biochemical investigations over several decades have associated NAA with myelin lipid synthesis and energy metabolism. However, studies have been hampered by an inability to identify the gene for the NAA biosynthetic enzyme aspartate N-acetyltransferase (Asp-NAT). A very recent report has identified Nat8l as the gene encoding Asp-NAT and confirmed that the only child diagnosed with a lack of NAA on brain magnetic resonance spectrograms has a 19-bp deletion in this gene. Based on in vitro Nat8l expression studies the researchers concluded that many previous biochemical investigations have been technically flawed and that NAA may not be associated with brain energy or lipid metabolism. In studies done concurrently in our laboratory we have demonstrated via cloning, expression, specificity for acetylation of aspartate, responsiveness to methamphetamine treatment, molecular modeling and comparative immunolocalization that NAT8L is the NAA biosynthetic enzyme Asp-NAT. We conclude that NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system, thus linking it to both lipid synthesis and energy metabolism. Published by Elsevier BM. C1 [Ariyannur, Prasanth S.; Moffett, John R.; Arun, Peethambaran; Madhavarao, Chikkathur N.; Namboodiri, Aryan M. A.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Mol & Cell Biol Program, Neurosci Program,APG, Bethesda, MD 20814 USA. [Manickam, Pachiappan] GenPro Diagnost Inc, Germantown, MD USA. [Pattabiraman, Nagarajan] Walter Reed Army Inst Res, Dept Struct & Mol Biol, BRD, Silver Spring, MD USA. [Nitta, Atsumi] Toyama Univ, Dept Pharmaceut Therapy & Neuropharmacol, Fac Pharmaceut Sci, Grad Sch Med & Pharmaceut Sci, Toyama, Japan. [Nabeshima, Toshitaka] Meijo Univ, Dept Chem Pharmacol, Grad Sch Pharmaceut Sci, Nagoya, Aichi, Japan. RP Namboodiri, AMA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Mol & Cell Biol Program, Neurosci Program,APG, 4301 Jones Bridge Rd,Bldg C,Rm 2069, Bethesda, MD 20814 USA. EM anamboodiri@usuhs.mil RI Pattabiraman, Nagarjan /A-9347-2011; OI Ariyannur, Prasanth/0000-0003-0888-8094 FU USUHS [R070WG. Nat8l] FX Research supported by USUHS internal grant R070WG. Nat8l (NCBI accession ID NM_001001985) open reading frame DNA was commercially synthesized by GenScript USA Inc., Piscataway, NJ. NR 54 TC 36 Z9 39 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD JUN 4 PY 2010 VL 1335 BP 1 EP 13 DI 10.1016/j.brainres.2010.04.008 PG 13 WC Neurosciences SC Neurosciences & Neurology GA 611CX UT WOS:000278789400001 PM 20385109 ER PT J AU Loparic, M Wirz, D Daniels, AU Raiteri, R VanLandingham, MR Guex, G Martin, I Aebi, U Stolz, M AF Loparic, Marko Wirz, Dieter Daniels, A. U. Raiteri, Roberto VanLandingham, Mark R. Guex, Geraldine Martin, Ivan Aebi, Ueli Stolz, Martin TI Micro- and Nanomechanical Analysis of Articular Cartilage by Indentation-Type Atomic Force Microscopy: Validation with a Gel-Microfiber Composite SO BIOPHYSICAL JOURNAL LA English DT Article ID UNCONFINED COMPRESSION; MECHANICAL-PROPERTIES; ELASTIC-MODULUS; COLLAGEN; TISSUE; DEGENERATION; AGGREGATE; SAMPLES; MATRIX; PROBE AB As documented previously, articular cartilage exhibits a scale-dependent dynamic stiffness when probed by indentation-type atomic force microscopy (IT-AFM). In this study, a micrometer-size spherical tip revealed an unimodal stiffness distribution (which we refer to as microstiffness), whereas probing articular cartilage with a nanometer-size pyramidal tip resulted in a bimodal nanostiffness distribution. We concluded that indentation of the cartilage's soft proteoglycan (PG) gel gave rise to the lower nanostiffness peak, whereas deformation of its collagen fibrils yielded the higher nanostiffness peak. To test our hypothesis, we produced a gel-microfiber composite consisting of a chondroitin sulfate-containing agarose gel and a fibrillar poly(ethylene glycol)-terephthalate/poly(butylene)-terephthalate block copolymer. In striking analogy to articular cartilage, the microstiffness distribution of the synthetic composite was unimodal, whereas its nanostiffness exhibited a bimodal distribution. Also, similar to the case with cartilage, addition of the negatively charged chondroitin sulfate rendered the gel-microfiber composite's water content responsive to salt. When the ionic strength of the surrounding buffer solution increased from 0.15 to 2 M NaCl, the cartilage's microstiffness increased by 21%, whereas that of the synthetic biomaterial went up by 31%. When the nanostiffness was measured after the ionic strength was raised by the same amount, the cartilage's lower peak increased by 28%, whereas that of the synthetic biomaterial went up by 34%. Of interest, the higher peak values remained unchanged for both materials. Taken together, these results demonstrate that the nanoscale lower peak is a measure of the soft PG gel, and the nanoscale higher peak measures collagen fibril stiffness. In contrast, the micrometer-scale measurements fail to resolve separate stiffness values for the PG and collagen fibril moieties. Therefore, we propose to use nanostiffness as a new biomarker to analyze structure-function relationships in normal, diseased, and engineered cartilage. C1 [Loparic, Marko; Aebi, Ueli; Stolz, Martin] Univ Basel, Biozentrum, ME Muller Inst Struct Biol, Basel, Switzerland. [Wirz, Dieter; Daniels, A. U.] Univ Basel, Fac Med, Lab Biomech & Biocalometry, Basel, Switzerland. [Raiteri, Roberto] Univ Genoa, Dept Biophys & Elect Engn, Genoa, Italy. [VanLandingham, Mark R.] USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Guex, Geraldine; Martin, Ivan] Univ Basel Hosp, Dept Surg, CH-4031 Basel, Switzerland. [Loparic, Marko; Guex, Geraldine; Martin, Ivan] Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland. [Stolz, Martin] Univ Southampton, Sch Engn Sci, Natl Ctr Adv Tribol Southampton, Southampton, Hants, England. RP Stolz, M (reprint author), Univ Basel, Biozentrum, ME Muller Inst Struct Biol, Basel, Switzerland. EM mstolz@nanoinspec.com FU Swiss National Science Foundation; EU [LSHG-CT-2004-502828]; Hardy und Otto Frey-Zund Stiftung; M.E. Muller Foundation of Switzerland FX This work was supported by a National Center of Competence in Research program grant for Nanoscale Science awarded by the Swiss National Science Foundation, the EU Meshwork of Excellence 3D-EM project No. LSHG-CT-2004-502828, the M.E. Muller Foundation of Switzerland, and Canton Basel-Stadt. Part of the work was also supported by the Hardy und Otto Frey-Zund Stiftung and by private patients supporting the efforts of the University of Basel Laboratory for Orthopedic Biomechanics. NR 47 TC 71 Z9 71 U1 4 U2 50 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD JUN 2 PY 2010 VL 98 IS 11 BP 2731 EP 2740 DI 10.1016/j.bpj.2010.02.013 PG 10 WC Biophysics SC Biophysics GA 606LW UT WOS:000278427500037 PM 20513418 ER PT J AU Granger, DM Lopansri, BK Butcher, D Wong, S Tavakoli, NP Backenson, PB Campbell, M Fine, A Ackelsberg, J Freedman, A Fink, M Artsob, H Holbrook, MR DeBiasi, RL Waterman, PE Rollin, PE MacNeil, A Panella, AJ Kosoy, O Lanciotti, RS Campbell, GL Staples, JE Fischer, M Gibney, KB Knust, B AF Granger, D. M. Lopansri, B. K. Butcher, D. Wong, S. Tavakoli, N. P. Backenson, P. B. Campbell, M. Fine, A. Ackelsberg, J. Freedman, A. Fink, M. Artsob, H. Holbrook, M. R. DeBiasi, R. L. Waterman, P. E. Rollin, P. E. MacNeil, A. Panella, A. J. Kosoy, O. Lanciotti, R. S. Campbell, G. L. Staples, J. E. Fischer, M. Gibney, K. B. Knust, B. TI Tick-Borne Encephalitis Among U.S. Travelers to Europe and Asia-2000-2009 (Reprinted from MMWR, vol 59, pg 335-338, 2010) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 [Granger, D. M.] Univ Utah, Sch Med, Salt Lake City, UT 84112 USA. [Granger, D. M.] Univ Utah, Vet Affairs Med Ctr, Salt Lake City, UT 84112 USA. [Lopansri, B. K.] Loyola Univ Med Ctr, Maywood, IL USA. [Lopansri, B. K.] Loyola Univ, Hines VA Hosp, New Orleans, LA 70118 USA. [Butcher, D.] Teton Internal Med, Jackson, WY USA. [Wong, S.; Tavakoli, N. P.; Backenson, P. B.] New York State Dept Hlth, Albany, NY 12237 USA. [Campbell, M.; Fine, A.; Ackelsberg, J.] New York City Dept Hlth & Mental Hyg, New York, NY USA. [Freedman, A.; Fink, M.] New York Presbyterian Weill Cornell Med Ctr, New York, NY USA. [Holbrook, M. R.] Univ Texas Med Br, Galveston, TX USA. [Waterman, P. E.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Gibney, K. B.; Knust, B.] CDC, Atlanta, GA 30333 USA. RP Granger, DM (reprint author), Univ Utah, Sch Med, Salt Lake City, UT 84112 USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUN 2 PY 2010 VL 303 IS 21 BP 2132 EP 2135 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 603BE UT WOS:000278182100010 ER PT J AU Rice, RD Ayubi, FS Shaub, ZJ Parker, DM Armstrong, PJ Tsai, JW AF Rice, Robert D. Ayubi, Farhan S. Shaub, Zachary J. Parker, David M. Armstrong, Peter J. Tsai, John W. TI Comparison of Surgisis(A (R)), AlloDerm(A (R)), and Vicryl Woven Mesh(A (R)) Grafts for Abdominal Wall Defect Repair in an Animal Model SO AESTHETIC PLASTIC SURGERY LA English DT Article DE Hernia; Abdominal wall; Surgisis (R); Vicryl (R); AlloDerm (R) ID SMALL-INTESTINAL SUBMUCOSA; HERNIA REPAIR; RAT MODEL; SURGICAL-TREATMENT; HOST RESPONSE; MESH; RECONSTRUCTION; POLYPROPYLENE; COLLAGEN; CLOSURE AB Surgisis(A (R)) and AlloDerm(A (R)), two biosynthetic materials, have been previously used with success in abdominal wall repairs in the setting of contaminated fields. Historically, Vicryl Woven Mesh(A (R)), a synthetic material, has also been used in such settings as a temporary bridge for abdominal wall reconstruction. This study compares Surgisis and AlloDerm with Vicryl Woven Mesh with respect to tensile strength, collagen remodeling, and neovascularization using a rat hernia model. A prospective randomized trial of 54 Sprague-Dawley rats were assigned to the Surgisis, AlloDerm, or Vicryl Woven Mesh group with baseline, 30-day, and 60-day end points. A 1.5-cm x 5.0-cm defect was created in the right abdominis rectus muscle and repaired with an underlay bridge graft using the different treatment materials. Tensile strength was measured using an Instron tensiometer. Histologic specimens were evaluated for neovascularization, collagen deposition, and collagen organization at the 30- and 60-day time points. Surgisis had significantly greater tensile strength compared to Vicryl Woven Mesh at the baseline time point (0.142 vs. 0.091 MPa, p < 0.05). There were no differences between groups tensile strength at 30 or 60 days postoperatively. The Vicryl Woven Mesh and AlloDerm groups showed increases in tensile strength at 30 days postoperatively versus baseline (p < 0.05). Vicryl Woven Mesh, Surgisis, and AlloDerm all showed increases in tensile strength at 60 days postoperatively compared to 30 days postoperatively and at baseline (p < 0.05). Surgisis and AlloDerm had significantly greater (p < 0.05) amounts of collagen deposition and organization at 30 and 60 days compared to Vicryl Woven Mesh. There was no significant difference between AlloDerm and Surgisis with respect to collagen deposition and organization. Surgisis and AlloDerm showed a significantly greater amount (p < 0.05) of neovascularization than Vicryl Woven Mesh at both time points. In addition, Surgisis had a significantly greater amount (p < 0.05) of neovascularization than AlloDerm at both 30 and 60 days. Surgisis has increased baseline tensile strength compared to Vicryl Woven Mesh. Tensile strength in Vicryl Woven Mesh is equal to biosynthetic grafts after tissue incorporation. Biosynthetic grafts showed superior collagen deposition and organization. Surgisis mesh showed increased neovascularization over both AlloDerm and Vicryl Woven Mesh. C1 [Rice, Robert D.; Ayubi, Farhan S.; Shaub, Zachary J.; Armstrong, Peter J.; Tsai, John W.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. [Parker, David M.] 121 Combat Support Hosp, Dept Gen Surg, Yongsan, South Korea. RP Rice, RD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. EM s6rrice@yahoo.com FU Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center. FX Research was supported by internal funding from the Department of Clinical Investigation, Dwight David Eisenhower Army Medical Center. Thanks to Major Julie Stephens-De-Valle, DVM, Dr. Malcolm Kling, Mr. Eugene Cauley, Mr. David Robinson, and Ms. Leticia Simon for their support with animal care and surgery. AlloDerm (R) was supplied for evaluation purposes by Lifecell Corp. The authors have no financial ties to or interest in the manufacture of Vicryl (R), Surgisis (R), or AlloDerm (R). The views of the authors do not purport to reflect the position of the Department of the Army or the Department of Defense (paragraph 4-3), AR 360-5. NR 24 TC 28 Z9 31 U1 2 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0364-216X J9 AESTHET PLAST SURG JI Aesthet. Plast. Surg. PD JUN PY 2010 VL 34 IS 3 BP 290 EP 296 DI 10.1007/s00266-009-9449-2 PG 7 WC Surgery SC Surgery GA 597TC UT WOS:000277783500005 PM 19967358 ER PT J AU Ho, JC Hodges, DH Yu, WB AF Ho, Jimmy C. Hodges, Dewey H. Yu, Wenbin TI Energy Transformation to Generalized Timoshenko Form for Nonuniform Beams SO AIAA JOURNAL LA English DT Article ID SECTION C1 [Hodges, Dewey H.] Georgia Inst Technol, Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA. [Yu, Wenbin] Utah State Univ, Dept Mech & Aerosp Engn, Logan, UT 84322 USA. RP Ho, JC (reprint author), USA, ELORET Corp, Aeroflightdynam Directorate, Ames Res Ctr, Mail Stop 215-1, Moffett Field, CA 94035 USA. EM jimmy.c.ho@us.army.mil; dhodges@gatech.edu; wenbin@engineering.usu.edu RI Yu, Wenbin/B-1916-2009 FU U.S. Army Vertical Lift Research Center of Excellence at Georgia Institute of Technology FX This research is supported by the U.S. Army Vertical Lift Research Center of Excellence at Georgia Institute of Technology and its affiliate program through subcontract at Utah State University. The Technical Monitor is Michael J. Rutkowski. NR 13 TC 2 Z9 2 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0001-1452 J9 AIAA J JI AIAA J. PD JUN PY 2010 VL 48 IS 6 BP 1268 EP 1272 DI 10.2514/1.J050160 PG 5 WC Engineering, Aerospace SC Engineering GA 605MY UT WOS:000278352900025 ER PT J AU Cupul-Uicab, LA Baird, DD Eggesbo, M Skjaerven, R Haug, K Longnecker, MP AF Cupul-Uicab, L. A. Baird, D. D. Eggesbo, M. Skjaerven, R. Haug, K. Longnecker, M. P. TI IN UTERO EXPOSURE TO CIGARETTE SMOKE AND WOMEN'S RISK OF FETAL LOSS LATER IN LIFE SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2010 CL Anaheim, SOLOMON ISLANDS SP Soc Epidemiol Res C1 [Cupul-Uicab, L. A.; Baird, D. D.; Eggesbo, M.; Skjaerven, R.; Haug, K.; Longnecker, M. P.] NIEHS, Epidemiol Branch, NIH,DHHS,USA, Res Triangle Pk, NC 27709 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2010 VL 171 SU 11 BP S27 EP S27 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 603QO UT WOS:000278223300109 ER PT J AU Gallaway, MS Bell, MR Millikan, AM Pecko, JA AF Gallaway, M. S. Bell, M. R. Millikan, A. M. Pecko, J. A. TI DEVELOPMENT OF A BEHAVIORAL HEALTH SURVEILLANCE PLAN AT A MILITARY INSTALLATION FOLLOWING A MASS SHOOTING SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2010 CL Anaheim, SOLOMON ISLANDS SP Soc Epidemiol Res C1 [Gallaway, M. S.; Bell, M. R.; Millikan, A. M.; Pecko, J. A.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2010 VL 171 SU 11 BP S75 EP S75 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 603QO UT WOS:000278223300301 ER PT J AU Herrell, RK Bliese, PD Hoge, CW AF Herrell, R. K. Bliese, P. D. Hoge, C. W. TI THE IMPACT OF DEPRESSION, ANXIETY, AND PTSD ON FUNCTIONAL IMPAIRMENT IN ACTIVE DUTY SOLDIERS SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract CT 43rd Annual Meeting of the Society-for-Epidemiologic-Research CY JUN 23-26, 2010 CL Anaheim, SOLOMON ISLANDS SP Soc Epidemiol Res C1 [Herrell, R. K.; Bliese, P. D.; Hoge, C. W.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 2010 VL 171 SU 11 BP S92 EP S92 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 603QO UT WOS:000278223300367 ER PT J AU Kosoy, M Bai, Y Sheff, K Morway, C Baggett, H Maloney, SA Boonmar, S Bhengsri, S Dowell, SF Sitdhirasdr, A Lerdthusnee, K Richardson, J Peruski, LF AF Kosoy, Michael Bai, Ying Sheff, Kelly Morway, Christina Baggett, Henry Maloney, Susan A. Boonmar, Sumalee Bhengsri, Saithip Dowell, Scott F. Sitdhirasdr, Anussorn Lerdthusnee, Kriangkrai Richardson, Jason Peruski, Leonard F. TI Identification of Bartonella Infections in Febrile Human Patients from Thailand and Their Potential Animal Reservoirs SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VINSONII SUBSP ARUPENSIS; SP-NOV; PREVALENCE; HENSELAE; STRAINS; RODENTS; GENE; ENDOCARDITIS; DIVERSITY; PATHOGENS AB To determine the role of Bartonella species as causes of acute febrile illness in humans from Thailand, we used a novel strategy of co-cultivation of blood with eukaryotic cells and subsequent phylogenetic analysis of Bartonella-specific DNA products. Bartonella species were identified in 14 blood clots from febrile patients. Sequence analysis showed that more than one-half of the genotypes identified in human patients were similar or identical to homologous sequences identified in rodents from Asia and were closely related to B. elizabethae, B. rattimassiliensis, and B. tribocorum. The remaining genotypes belonged to B. henselae, B. vinsonii, and B. tamiae. Among the positive febrile patients, animal exposure was common: 36% reported owning either dogs or cats and 71% reported rat exposure during the 2 weeks before illness onset. The findings suggest that rodents are likely reservoirs for a substantial portion of cases of human Bartonella infections in Thailand. C1 [Kosoy, Michael; Bai, Ying; Sheff, Kelly; Morway, Christina] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Baggett, Henry; Maloney, Susan A.; Boonmar, Sumalee; Bhengsri, Saithip; Peruski, Leonard F.] Int Emerging Infect Program, Nonthaburi, Thailand. [Dowell, Scott F.] Ctr Dis Control & Prevent, Off Global Hlth, Atlanta, GA USA. [Sitdhirasdr, Anussorn] Minist Publ Hlth, Nonthaburi, Thailand. [Lerdthusnee, Kriangkrai] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Kosoy, M (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. EM mkosoy@cdc.gov RI Richardson, Jason/A-9441-2011 FU International Emerging Infections Program; Global Disease Detection Network of the United States Centers for Disease Control and Prevention FX This project was supported by the International Emerging Infections Program and Global Disease Detection Network of the United States Centers for Disease Control and Prevention. NR 27 TC 46 Z9 47 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2010 VL 82 IS 6 BP 1140 EP 1145 DI 10.4269/ajtmh.2010.09-0778 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 606XP UT WOS:000278462600029 PM 20519614 ER PT J AU Huber, MR Sturdivant, RX AF Huber, Michael R. Sturdivant, Rodney X. TI BUILDING A MODEL FOR SCORING 20 OR MORE RUNS IN A BASEBALL GAME SO ANNALS OF APPLIED STATISTICS LA English DT Article DE Exponential distribution; Poisson process; memoryless property; rare baseball events; goodness-of-fit test AB How often can we expect a Major League Baseball team to score at least 20 runs in a single game? Considered a rare event in baseball, the outcome of scoring at least 20 runs in a game has occurred 224 times during regular season games since 1901 in the American and National Leagues. Each outcome is modeled as a Poisson process; the time of occurrence of one of these events does not affect the next future occurrence. Using various distributions, probabilities of events are generated, goodness-of-fit tests are conducted, and predictions of future events are offered. The statistical package R is employed for analysis. C1 [Huber, Michael R.] Muhlenberg Coll, Dept Math & Comp Sci, Allentown, PA 18104 USA. US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Huber, MR (reprint author), Muhlenberg Coll, Dept Math & Comp Sci, Allentown, PA 18104 USA. EM huber@muhlenberg.edu NR 2 TC 0 Z9 0 U1 0 U2 1 PU INST MATHEMATICAL STATISTICS PI CLEVELAND PA 3163 SOMERSET DR, CLEVELAND, OH 44122 USA SN 1932-6157 J9 ANN APPL STAT JI Ann. Appl. Stat. PD JUN PY 2010 VL 4 IS 2 BP 791 EP 804 DI 10.1214/09-AOAS301 PG 14 WC Statistics & Probability SC Mathematics GA 671RW UT WOS:000283528500012 ER PT J AU Levin, LI Munger, KL O'Reilly, EJ Falk, KI Ascherio, A AF Levin, Lynn I. Munger, Kassandra L. O'Reilly, Ellis J. Falk, Kerstin I. Ascherio, Alberto TI Primary Infection with the Epstein-Barr Virus and Risk of Multiple Sclerosis SO ANNALS OF NEUROLOGY LA English DT Article ID FOLLOW-UP; MONONUCLEOSIS AB To determine whether multiple sclerosis (MS) risk increases following primary infection with the Epstein-Barr virus (EBV), we conducted a nested case-control study including 305 individuals who developed MS and 610 matched controls selected among the >8 million active-duty military personnel whose serum has been stored in the Department of Defense Serum Repository. Time of EBV infection was determined by measuring antibody titers in serial serum samples collected before MS onset among cases, and on matched dates among controls. Ten (3.3%) cases and 32 (5.2%) controls were initially EBV negative. All of the 10 EBV-negative cases became EBV positive before MS onset; in contrast, only 35.7% (n = 10) of the 28 controls with follow-up samples seroconverted (exact p value = 0.0008). We conclude that MS risk is extremely low among individuals not infected with EBV, but it increases sharply in the same individuals following EBV infection. ANN NEUROL 2010;67:824-830 C1 [O'Reilly, Ellis J.; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Levin, Lynn I.] Walter Reed Army Inst Res, Dept Epidemiol, Div Prevent Med, Silver Spring, MD USA. [Munger, Kassandra L.; O'Reilly, Ellis J.; Ascherio, Alberto] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Falk, Kerstin I.] Karolinska Inst, Dept Virol, Swedish Inst Infect Dis Control, Solna, Sweden. [Falk, Kerstin I.] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Solna, Sweden. [Ascherio, Alberto] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA. [Ascherio, Alberto] Harvard Univ, Sch Med, Boston, MA 02115 USA. RP Ascherio, A (reprint author), Harvard Univ, Sch Publ Hlth, Dept Epidemiol, 665 Huntington Ave,Bldg 2,Room 335, Boston, MA 02115 USA. EM aascheri@hsph.harvard.edu FU National Institute of Neurological Disorder and Stroke [NS46635, N5042194] FX This work was supported by the National Institute of Neurological Disorder and Stroke (grants NS46635 and N5042194 to A.A). The sponsor of this study had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; nor did it participate in the decision to submit for publication. NR 24 TC 115 Z9 116 U1 3 U2 17 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD JUN PY 2010 VL 67 IS 6 BP 824 EP 830 DI 10.1002/ana.21978 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 603KV UT WOS:000278208400018 PM 20517945 ER PT J AU Ritenour, AE Blackbourne, LH Kelly, JF McLaughlin, DF Pearse, LA Holcomb, JB Wade, CE AF Ritenour, Amber E. Blackbourne, Lorne H. Kelly, Joseph F. McLaughlin, Daniel F. Pearse, Lisa A. Holcomb, John B. Wade, Charles E. TI Incidence of Primary Blast Injury in US Military Overseas Contingency Operations A Retrospective Study SO ANNALS OF SURGERY LA English DT Article ID INCREASED RESOURCE UTILIZATION; COMBAT CASUALTY CARE; IRAQI-FREEDOM; BLOOD-TRANSFUSION; ENDURING FREEDOM; BATTLEFIELD CASUALTIES; UNITED-STATES; TRAUMA; EXPERIENCE; WAR AB Objectives: The present retrospective study was performed to determine the incidence and outcome of primary blast injury and to identify possible changes over the course of the conflicts between 2003 and 2006. Summary Background Data: Combat physicians treating patients injured in overseas contingency operations observed an increase in the severity of explosion injuries occurring during this period. Methods: This retrospective study included service members injured in explosions between March 2003 and October 2006. The Joint Theater Trauma Registry provided demographic information, injury severity score, and International Classification of Diseases 9 codes used to diagnose primary blast injury. Autopsy reports of the last 497 combat-related deaths of 2006 were also reviewed. Results: Of 9693 admissions, of which 6687 were injured in combat, 4765 (49%) were injured by explosions: 2588 in 2003-2004 and 1935 in 2005-2006. Dates of injury were unavailable for 242 casualties. Injury severity score (9 +/- 10 vs. 11 +/- 10, P < 0.0001) and incidence of primary blast injury (12% vs. 15%, P < 0.01) increased. The return-to-duty rate decreased (40% vs. 18%, P < 0.001), but mortality remained low (1.4% vs. 1.5%, P = NS). There was no significant difference in incidence of primary blast injury between personnel who were killed in action and those who died of wounds at a medical facility. Conclusions: Injury severity and incidence of primary blast injury increased during the 4-year period, whereas return-to-duty rates decreased. Despite increasingly devastating injuries, the mortality rate due to explosion injuries remained low and unchanged. C1 [Ritenour, Amber E.; Blackbourne, Lorne H.; Kelly, Joseph F.; McLaughlin, Daniel F.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Pearse, Lisa A.] Armed Forces Inst Pathol, Off Armed Forces Med Examiner, Rockville, MD USA. [Holcomb, John B.; Wade, Charles E.] Univ Texas Hlth, Ctr Translat Injury Res, Houston, TX 77030 USA. RP Wade, CE (reprint author), Univ Texas Hlth, US Ctr Translat Injury Res, 6410 Fannin,UPB Suite 1100, Houston, TX 77030 USA. EM Charles.E.Wade@uth.tmc.edu FU US Army Medical Research and Material Command FX Supported by the US Army Medical Research and Material Command. NR 46 TC 36 Z9 36 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD JUN PY 2010 VL 251 IS 6 BP 1140 EP 1144 DI 10.1097/SLA.0b013e3181e01270 PG 5 WC Surgery SC Surgery GA 608DE UT WOS:000278561700023 PM 20485126 ER PT J AU Ellsworth, RE Ellsworth, DL Weyandt, JD Fantacone-Campbell, JL Deyarmin, B Hooke, JA Shriver, CD AF Ellsworth, Rachel E. Ellsworth, Darrell L. Weyandt, Jamie D. Fantacone-Campbell, Jamie L. Deyarmin, Brenda Hooke, Jeffrey A. Shriver, Craig D. TI Chromosomal Alterations in Pure Nonneoplastic Breast Lesions: Implications for Breast Cancer Progression SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article ID ATYPICAL DUCTAL HYPERPLASIA; COLUMNAR CELL LESIONS; CARCINOMA IN-SITU; COMPARATIVE GENOMIC HYBRIDIZATION; NORMAL-MAMMARY-EPITHELIUM; GENETIC ALTERATIONS; ESTROGEN-RECEPTOR; TUBULAR CARCINOMA; DISEASE; HETEROZYGOSITY AB Columnar cell lesions (CCL) and atypical ductal hyperplasia (ADH) frequently coexist and share molecular changes with in situ and invasive components, suggesting that CCL and ADH may be precursors to breast cancer. These conclusions are largely based on studies examining CCL and/or ADH from patients diagnosed with more advanced disease. We assessed allelic imbalance (AI) in pure CCL or ADH specimens to characterize molecular changes in nonneoplastic breast lesions. DNA samples were obtained from laser-microdissected pure CCL (n = 42) or ADH (n = 31). AI was assessed at 26 chromosomal regions commonly altered in breast cancer. Data were analyzed using Fisher's exact and Student's t-tests using a cutoff of P < 0.05. The average AI frequency was 6.2% in CCL and 6.1% in ADH;similar to 33% of nonneoplastic lesions had no detectable genetic changes. Levels of AI in CCL and ADH were significantly (P < 0.0001) lower than observed in either low- or high-grade ductal carcinoma in situ (DCIS) lesions. Genetic changes characteristic of in situ and invasive disease, especially on chromosomes 16q and 17p, were infrequent in pure nonneoplastic lesions. Pure CCL and ADH lesions demonstrate lower levels of genetic alterations than DCIS, invasive carcinomas or CCL/ADH lesions from cancerous breasts; alterations of chromosomes 16q and 17p were not detected. Pure CCL and ADH lesions are not genetically advanced, and molecular profiles do not support these lesions as obligatory precursors to more advanced disease. Molecular differences between pure and synchronous lesions support re-evaluation of current models of disease initiation, progression, and risk. C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Darrell L.; Weyandt, Jamie D.; Deyarmin, Brenda] Windber Res Inst, Clin Breast Care Project, Windber, PA USA. [Fantacone-Campbell, Jamie L.; Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Ellsworth, RE (reprint author), Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org FU US Department of Defense [MDA W81XWH-05-2-0075, Protocol 01-20006] FX This research was supported by a grant from the US Department of Defense (Military Molecular Medicine Initiative MDA W81XWH-05-2-0075, Protocol 01-20006). The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense. NR 44 TC 7 Z9 7 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD JUN PY 2010 VL 17 IS 6 BP 1688 EP 1694 DI 10.1245/s10434-010-0910-x PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 595EU UT WOS:000277594300032 PM 20107913 ER PT J AU Chavchich, M Gerena, L Peters, J Chen, NH Cheng, Q Kyle, DE AF Chavchich, Marina Gerena, Lucia Peters, Jennifer Chen, Nanhua Cheng, Qin Kyle, Dennis E. TI Role of pfmdr1 Amplification and Expression in Induction of Resistance to Artemisinin Derivatives in Plasmodium falciparum SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID SERCA-TYPE PFATPASE6; IN-VITRO; HALOFANTRINE RESISTANCE; MEFLOQUINE RESISTANCE; MALARIA PARASITES; AMINO-ACID; CHLOROQUINE RESISTANCE; S769N MUTATION; BINDING SITE; COPY NUMBER AB Artemisinin and its derivatives are the most rapidly acting and efficacious antimalarial drugs currently available. Although resistance to these drugs has not been documented, there is growing concern about the potential for resistance to develop. In this paper we report the selection of parasite resistance to artelinic acid (AL) and artemisinin (QHS) in vitro and the molecular changes that occurred during the selection. Exposure of three Plasmodium falciparum lines (W2, D6, and TM91C235) to AL resulted in decreases in parasite susceptibilities to AL and QHS, as well as to mefloquine, quinine, halofantrine, and lumefantrine. The changes in parasite susceptibility were accompanied by increases in the copy number, mRNA expression, and protein expression of the pfmdr1 gene in the resistant progenies of W2 and TM91C235 parasites but not in those of D6 parasites. No changes were detected in the coding sequences of the pfmdr1, pfcrt, pfatp6, pftctp, and pfubcth genes or in the expression levels of pfatp6 and pftctp. Our data demonstrate that P. falciparum lines have the capacity to develop resistance to artemisinin derivatives in vitro and that this resistance is achieved by multiple mechanisms, to include amplification and increased expression of pfmdr1, a mechanism that also confers resistance to mefloquine. This observation is of practical importance, because artemisinin drugs are often used in combination with mefloquine for the treatment of malaria. C1 [Kyle, Dennis E.] Univ S Florida, Coll Publ Hlth, Dept Global Hlth, Tampa, FL 33612 USA. [Chavchich, Marina; Peters, Jennifer; Chen, Nanhua; Cheng, Qin; Kyle, Dennis E.] Australian Army Malaria Inst, Enoggera, Qld 4051, Australia. [Chavchich, Marina; Peters, Jennifer; Cheng, Qin] Queensland Inst Med Res, Herston, Qld 4029, Australia. [Gerena, Lucia; Kyle, Dennis E.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Kyle, DE (reprint author), Univ S Florida, Coll Publ Hlth, Dept Global Hlth, 3720 Spectrum Blvd, Tampa, FL 33612 USA. EM dkyle@health.usf.edu FU National Institutes of Health [R01 AI058973]; U.S. Army Military Infectious Diseases Research Program FX The project was supported by the National Institutes of Health (R01 AI058973) and the U.S. Army Military Infectious Diseases Research Program. NR 49 TC 65 Z9 66 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2010 VL 54 IS 6 BP 2455 EP 2464 DI 10.1128/AAC.00947-09 PG 10 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 597KO UT WOS:000277756000023 PM 20350946 ER PT J AU Jabbour, RE Deshpande, SV Wade, MM Stanford, MF Wick, CH Zulich, AW Skowronski, EW Snyder, AP AF Jabbour, Rabih E. Deshpande, Samir V. Wade, Mary Margaret Stanford, Michael F. Wick, Charles H. Zulich, Alan W. Skowronski, Evan W. Snyder, A. Peter TI Double-Blind Characterization of Non-Genome-Sequenced Bacteria by Mass Spectrometry-Based Proteomics SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID ASSISTED-LASER-DESORPTION/IONIZATION; PROTEIN IDENTIFICATION TECHNOLOGY; RAPID IDENTIFICATION; SHOTGUN PROTEOMICS; TANDEM; DATABASE; DIFFERENTIATION; MICROORGANISMS; MIXTURES; SPECTRA AB Due to the possibility of a biothreat attack on civilian or military installations, a need exists for technologies that can detect and accurately identify pathogens in a near-real-time approach. One technology potentially capable of meeting these needs is a high-throughput mass spectrometry (MS)-based proteomic approach. This approach utilizes the knowledge of amino acid sequences of peptides derived from the proteolysis of proteins as a basis for reliable bacterial identification. To evaluate this approach, the tryptic digest peptides generated from double-blind biological samples containing either a single bacterium or a mixture of bacteria were analyzed using liquid chromatography-tandem mass spectrometry. Bioinformatic tools that provide bacterial classification were used to evaluate the proteomic approach. Results showed that bacteria in all of the double-blind samples were accurately identified with no false-positive assignment. The MS proteomic approach showed strain-level discrimination for the various bacteria employed. The approach also characterized double-blind bacterial samples to the respective genus, species, and strain levels when the experimental organism was not in the database due to its genome not having been sequenced. One experimental sample did not have its genome sequenced, and the peptide experimental record was added to the virtual bacterial proteome database. A replicate analysis identified the sample to the peptide experimental record stored in the database. The MS proteomic approach proved capable of identifying and classifying organisms within a microbial mixture. C1 [Jabbour, Rabih E.] SAIC, Edgewood Area, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. [Deshpande, Samir V.] Sci & Technol Corp, Edgewood, MD 21040 USA. [Wade, Mary Margaret; Stanford, Michael F.; Wick, Charles H.; Zulich, Alan W.; Skowronski, Evan W.; Snyder, A. Peter] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Jabbour, RE (reprint author), SAIC, Edgewood Area, Gunpowder Branch, Bldg E3160, Aberdeen Proving Ground, MD 21010 USA. EM rabih.e.jabbour@saic.com NR 30 TC 20 Z9 20 U1 0 U2 12 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUN PY 2010 VL 76 IS 11 BP 3637 EP 3644 DI 10.1128/AEM.00055-10 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 598WW UT WOS:000277871400027 PM 20363779 ER PT J AU Du, Y Gisselberg, JE Johnson, JD Lee, PJ Prigge, ST Bachmann, BO AF Du, Yu Gisselberg, Jolyn E. Johnson, Jacob D. Lee, Patricia J. Prigge, Sean T. Bachmann, Brian O. TI Lactococcus lactis fabH, Encoding beta-Ketoacyl-Acyl Carrier Protein Synthase, Can Be Functionally Replaced by the Plasmodium falciparum Congener SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID FATTY-ACID SYNTHESIS; ANTIBIOTIC PROPERTIES; III PFKASIII; DISCOVERY; BIOSYNTHESIS; EXPRESSION; INHIBITOR; SEQUENCE; TARGET; ENZYME AB Plasmodium falciparum, in addition to scavenging essential fatty acids from its intra-and intercellular environments, possesses a functional complement of type II fatty acid synthase (FAS) enzymes targeted to the apicoplast organelle. Recent evidence suggests that products of the plasmodial FAS II system may be critical for the parasite's liver-to-blood cycle transition, and it has been speculated that endogenously generated fatty acids may be precursors for essential cofactors, such as lipoate, in the apicoplast. beta-Ketoacyl-acyl carrier protein (ACP) synthase III (pfKASIII or FabH) is one of the key enzymes in the initiating steps of the FAS II pathway, possessing two functions in P. falciparum: the decarboxylative thio-Claisen condensation of malonyl-ACP and various acyl coenzymes A (acyl-CoAs; KAS activity) and the acetyl-CoA: ACP transacylase reaction (ACAT). Here, we report the generation and characterization of a hybrid Lactococcus lactis strain that translates pfKASIII instead of L. lactis fabH to initiate fatty acid biosynthesis. The L. lactis expression vector pMG36e was modified for the efficient overexpression of the plasmodial gene in L. lactis. Transcriptional analysis indicated high-efficiency overexpression, and biochemical KAS and ACAT assays confirm these activities in cell extracts. Phenotypically, the L. lactis strain expressing pfKASIII has a growth rate and fatty acid profiles that are comparable to those of the strain complemented with its endogenous gene, suggesting that pfKASIII can use L. lactis ACP as substrate and perform near-normal function in L. lactis cells. This strain may have potential application as a bacterial model for pfKASIII inhibitor prescreening. C1 [Bachmann, Brian O.] Vanderbilt Univ, Dept Chem, Stevenson Ctr 7300, Nashville, TN 37232 USA. [Gisselberg, Jolyn E.; Prigge, Sean T.] Johns Hopkins Sch Publ Hlth, Baltimore, MD 21205 USA. [Johnson, Jacob D.; Lee, Patricia J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Bachmann, BO (reprint author), Vanderbilt Univ, Dept Chem, Stevenson Ctr 7300, Nashville, TN 37232 USA. EM brian.bachmann@vanderbilt.edu FU ARMY STTR [W81XWH-07-C-0092]; Vanderbilt Institute of Chemical Biology; NIH [R01-AI065853]; Johns Hopkins Malaria Research Institute; Bloomberg Family Foundation FX This work funded by ARMY STTR W81XWH-07-C-0092 and the Vanderbilt Institute of Chemical Biology (B.O.B.). Additional support was provided by NIH R01-AI065853, the Johns Hopkins Malaria Research Institute, and the Bloomberg Family Foundation (S.T.P.). NR 23 TC 3 Z9 5 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUN PY 2010 VL 76 IS 12 BP 3959 EP 3966 DI 10.1128/AEM.00170-10 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 606ID UT WOS:000278415300022 PM 20418430 ER PT J AU Ketchman, S O'Garo, K AF Ketchman, Stacey O'Garo, Keisha TI Chronic Pain Biofeedback Program for Active Duty Service Members SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK LA English DT Meeting Abstract DE Chronic Pain; Military; Biofeedback C1 [Ketchman, Stacey] Womack Army Med Ctr, Ft Bragg, NC 28307 USA. EM staceyann76@yahoo.com NR 0 TC 0 Z9 0 U1 1 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1090-0586 J9 APPL PSYCHOPHYS BIOF JI Appl. Psychophysiol. Biofeedback PD JUN PY 2010 VL 35 IS 2 BP 184 EP 184 PG 1 WC Psychology, Clinical SC Psychology GA 600YN UT WOS:000278025200027 ER PT J AU Msimanga, HZ Ollis, RJ AF Msimanga, Huggins Z. Ollis, Robert J., Jr. TI Discerning Some Tylenol Brands Using Attenuated Total Reflection Fourier Transform Infrared Data and Multivariate Analysis Techniques SO APPLIED SPECTROSCOPY LA English DT Article DE Attenuated total reflection; Fourier transform infrared spectroscopy; ATR-FT-IR; Tylenol (R); Acetaminophen; Multivariate statistical analysis techniques; Principal components analysis; PCA; Partial least squares discriminant analysis; PLS-DA; Analysis of variance; ANONA; Classification ID OFFSET RAMAN-SPECTROSCOPY; IONIZATION; HEROIN; DISCRIMINATION; IDENTIFICATION; IMPURITIES; SPECTRA AB Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were used to classify acetaminophen-containing medicines using their attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectra. Four formulations of Tylenol (Arthritis Pain Relief, Extra Strength Pain Relief, 8 Hour Pain Relief, and Extra Strength Pain Relief Rapid Release) along with 98% pure acetaminophen were selected for this study because of the similarity of their spectral features, with correlation coefficients ranging from 0.9857 to 0.9988. Before acquiring spectra for the predictor matrix, the effects on spectral precision with respect to sample particle size (determined by sieve size opening), force gauge of the ATR accessory, sample reloading, and between-tablet variation were examined. Spectra were baseline corrected and normalized to unity before multivariate analysis. Analysis of variance (ANONA) was used to study spectral precision. The large particles (35 mesh) showed large variance between spectra, while tine particles (120 mesh) indicated good spectral precision based on the F-test. Force gauge setting did not significantly affect precision. Sample reloading using the fine particle size and a constant force gauge setting of 50 units also did not compromise precision. Based on these observations, data acquisition for the predictor matrix was carried out with the fine particles (sieve size opening of 120 mesh) at a constant force gauge setting of 50 units. After removing outliers, PCA successfully classified the five samples in the first and second components, accounting for 45.0% and 24.5% of the variances, respectively. The four-component PLS-DA model (R(2)=0.925 and Q(2)=0.906) gave good test spectra predictions with an overall average of 0.961+/-7.1% RSD versus the expected 1.0 prediction for the 20 test spectra used. C1 [Msimanga, Huggins Z.] Kennesaw State Univ, Dept Chem & Biochem, Kennesaw, GA 30144 USA. [Ollis, Robert J., Jr.] USA, Criminal Invest Lab, F ABC, Forest Pk, GA 30297 USA. RP Msimanga, HZ (reprint author), Kennesaw State Univ, Dept Chem & Biochem, Kennesaw, GA 30144 USA. EM hmsimang@kennesaw.edu FU Department of Chemistry and Biochemistry at Kennesaw State University FX The authors acknowledge the Department of Chemistry and Biochemistry at Kennesaw State University for providing research facilities and the Dean's Mentor-Prot g program for financial support. NR 32 TC 2 Z9 2 U1 2 U2 9 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUN PY 2010 VL 64 IS 6 BP 657 EP 668 PG 12 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 609VN UT WOS:000278686100013 PM 20537234 ER PT J AU Thomas, JL Wilk, JE Riviere, LA McGurk, D Castro, CA Hoge, CW AF Thomas, Jeffrey L. Wilk, Joshua E. Riviere, Lyndon A. McGurk, Dennis Castro, Carl A. Hoge, Charles W. TI Prevalence of Mental Health Problems and Functional Impairment Among Active Component and National Guard Soldiers 3 and 12 Months Following Combat in Iraq SO ARCHIVES OF GENERAL PSYCHIATRY LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; US MILITARY COHORT; PRIMARY-CARE; DEPLOYMENT; AFGHANISTAN; CHECKLIST; SYMPTOMS; PTSD; WAR AB Context: A growing body of literature has demonstrated the association of combat in Iraq and Afghanistan with postdeployment mental health problems, particularly posttraumatic stress disorder (PTSD) and depression. However, studies have shown varying prevalence rates of these disorders based on different case definitions and have not assessed functional impairment, alcohol misuse, or aggressive behavior as comorbid factors occurring with PTSD and depression. Objectives: To (1) examine the prevalence rates of depression and PTSD using several case definitions including functional impairment, (2) determine the comorbidity of alcohol misuse or aggressive behaviors with depression or PTSD, and (3) compare rates between Active Component and National Guard soldiers at the 3- and 12-month time points following their deployment to Iraq. Design: Population-based, cross-sectional study. Setting: United States Army posts and National Guard armories. Participants: A total of 18 305 US Army soldiers from 4 Active Component and 2 National Guard infantry brigade combat teams. Interventions: Between 2004 and 2007, anonymous mental health surveys were collected at 3 and 12 months following deployment. Main Outcome Measures: Current PTSD, depression, functional impairment, alcohol misuse, and aggressive behavior. Results: Prevalence rates for PTSD or depression with serious functional impairment ranged between 8.5% and 14.0%, with some impairment between 23.2% and 31.1%. Alcohol misuse or aggressive behavior comorbidity was present in approximately half of the cases. Rates remained stable for the Active Component soldiers but increased across all case definitions from the 3- to 12-month time point for National Guard soldiers. Conclusions: The prevalence rates of PTSD and depression after returning from combat ranged from 9% to 31% depending on the level of functional impairment reported. The high comorbidity with alcohol misuse and aggression highlights the need for comprehensive postdeployment screening. Persistent or increased prevalence rates at 12 months compared with 3 months postdeployment illustrate the persistent effects of war zone service and provide important data to guide postdeployment care. C1 [Thomas, Jeffrey L.] USA, Med Res & Mat Command, Walter Reed Army Inst Res, Dept Mil Psychiat,Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [McGurk, Dennis] USA, Med Res & Mat Command, Walter Reed Army Inst Res, USA Med Res Unit Europe, Heidelberg, Germany. [Castro, Carl A.] USA, Med Res & Mat Command, Mil Operat Med Res Program, Ft Detrick, MD USA. RP Thomas, JL (reprint author), USA, Med Res & Mat Command, Walter Reed Army Inst Res, Dept Mil Psychiat,Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jeffrey.l.thomas@us.army.mil FU Military Operational Medicine Research Area Directorate, US Army Medical Research and Materiel Command, Fort Detrick, Maryland FX This study was supported by the Military Operational Medicine Research Area Directorate, US Army Medical Research and Materiel Command, Fort Detrick, Maryland. NR 26 TC 359 Z9 362 U1 10 U2 48 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-990X J9 ARCH GEN PSYCHIAT JI Arch. Gen. Psychiatry PD JUN PY 2010 VL 67 IS 6 BP 614 EP 623 PG 10 WC Psychiatry SC Psychiatry GA 605CD UT WOS:000278324000010 PM 20530011 ER PT J AU Hoge, CW Wilk, JE Herrell, R AF Hoge, Charles W. Wilk, Joshua E. Herrell, Richard TI Methodological Issues in Mild Traumatic Brain Injury Research SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Letter ID POSTTRAUMATIC-STRESS-DISORDER; SYMPTOMS; IRAQ C1 [Hoge, Charles W.; Wilk, Joshua E.; Herrell, Richard] Walter Reed Army Inst Res, Div Psychait & Neurosci, Silver Spring, MD 20910 USA. RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Div Psychait & Neurosci, Silver Spring, MD 20910 USA. NR 4 TC 4 Z9 4 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUN PY 2010 VL 91 IS 6 BP 963 EP 963 DI 10.1016/j.apmr.2010.02.005 PG 1 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 610SM UT WOS:000278755800021 PM 20510991 ER PT J AU Hardin, M Oh, JS White, CE Cohn, SM AF Hardin, Mark Oh, John S. White, Christopher E. Cohn, Stephen M. TI Effect of Stitch Length on Complications SO ARCHIVES OF SURGERY LA English DT Letter C1 [Hardin, Mark; White, Christopher E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Oh, John S.] Brooke Army Med Ctr, San Antonio, TX USA. [Cohn, Stephen M.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Hardin, M (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Rd, Ft Sam Houston, TX 78234 USA. EM mark.hardin@amedd.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JUN PY 2010 VL 145 IS 6 BP 600 EP 600 PG 1 WC Surgery SC Surgery GA 610XY UT WOS:000278774800024 PM 20566986 ER PT J AU Keen, EF Robinson, BJ Hospenthal, DR Aldous, WK Wolf, SE Chung, KK Murray, CK AF Keen, Edward F., III Robinson, Brian J. Hospenthal, Duane R. Aldous, Wade K. Wolf, Steven E. Chung, Kevin K. Murray, Clinton K. TI Incidence and bacteriology of burn infections at a military burn center SO BURNS LA English DT Article DE Burn; Infection; Antibiotic resistance; Acinetobacter; Klebsiella; Pseudomonas; Staphylococcus ID WOUND INFECTIONS; ACINETOBACTER-BAUMANNII; ENDURING FREEDOM; EARLY EXCISION; COLONIZATION; MORTALITY; OPERATIONS; SEPSIS; CALCOACETICUS; PREVENTION AB Considerable advancements in shock resuscitation and wound management have extended the survival of burned patients, increasing the risk of serious infection. We performed a 6-year review of bacteria identification and antibiotic susceptibility records at the US Army Institute of Surgical Research Burn Center between January 2003 and December 2008. The primary goal was to identify the bacteria recovered from patients with severe burns and determine how the bacteriology changes during extended hospitalization as influenced by population and burn severity. A total of 460 patients were admitted to the burn ICU with 3507 bacteria recovered from 13,727 bacteriology cultures performed. The most prevalent organisms recovered were Acinetobacter baumannii (780), Pseudomonas aeruginosa (703), Klebsiella pneumoniae (695) and Staphylococcus aureus (469). A. baumannii was most often recovered from combat-injured (58%) and S. aureus the most frequent isolate from local (46%) burn patients. Culture recovery rate of A. baumannii and S. aureus was highest during the first 15 hospital days (73% and 71%); while a majority of P. aeruginosa and K. pneumoniae were recovered after day 15 (63% and 53%). All 4 pathogens were recovered throughout the course of hospitalization. A. baumannii was the most prevalent pathogen recovered from patients with total body surface area (TBSA) burns less than 30% (203) and 30-60% (338) while P. aeruginosa was most prevalent in patients with burns greater than 60% TBSA (292). Shifting epidemiology of bacteria recovered during extended hospitalization, bacteriology differences between combat-injured and local burn patients, and impact of % TBSA may affect patient management decisions during the course of therapy. Published by Elsevier Ltd and ISBI C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Wolf, Steven E.; Chung, Kevin K.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 47 TC 36 Z9 39 U1 1 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 EI 1879-1409 J9 BURNS JI Burns PD JUN PY 2010 VL 36 IS 4 BP 461 EP 468 DI 10.1016/j.burns.2009.10.012 PG 8 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 598RQ UT WOS:000277856300003 PM 20045259 ER PT J AU Glasser, JS Landrum, ML Chung, KK Hospenthal, DR Renz, EM Wolf, SE Murray, CK AF Glasser, Jessie S. Landrum, Michael L. Chung, Kevin K. Hospenthal, Duane R. Renz, Evan M. Wolf, Steven E. Murray, Clinton K. TI Description of Streptococcus pneumoniae infections in burn patients SO BURNS LA English DT Article DE Burn; Streptococcus pneumoniae; Pneumococcus; Pneumococcal ID NOSOCOMIAL PNEUMOCOCCAL BACTEREMIA; WOUND INFECTIONS; UNITED-STATES; EPIDEMIOLOGY AB Background: Longer survival in burn patients has resulted in more infectious complications, typically with Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus. Although Streptococcus pneumoniae infections are common in the community and can cause nosocomial infections, the incidence and risk factors for pneumococcal infections in burn patients is unclear. Methods: We performed an electronic retrospective chart review to collect rates of and risk factors for S. pneumoniae infections in patients with thermal burns from March 2003 through June 2008. Results: Of the 1838 patients admitted to the burn center, 10 were infected (0.54% incidence). Patients presented with pneumonia (seven patients, 0.38% incidence) and bacteremia (three patients, 0.16% incidence) within a week of initial burn (median 1 day, range 0-8), often in the setting of bacterial co-infection (five patients). This group was mainly young males with median 28.8% total body surface area burns; 60% had concomitant inhalational injury. Most did not have traditional risk factors for pneumococcal infection but had objective signs of infection at time of positive culture and were treated with appropriate antibiotics. Two patients in this series died, although no mortality was attributed to S. pneumoniae. Conclusions: Pneumococcal disease is not common in burn patients and generally occurs early on in hospitalization after burn making it more likely to be a community-acquired pathogen rather than nosocomial in the burn population. It should be considered in the setting of sepsis or new pulmonary infiltrates within a week after burn, but typical empiric antibiotics against the usual burn pathogens should be adequate to also treat for pneumococcal infection. Published by Elsevier Ltd and ISBI C1 [Murray, Clinton K.] Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA. [Landrum, Michael L.; Hospenthal, Duane R.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Chung, Kevin K.; Renz, Evan M.; Wolf, Steven E.] USA, Inst Surg Res, Washington, DC USA. [Hospenthal, Duane R.; Wolf, Steven E.; Murray, Clinton K.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Infect Dis Serv, San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Clinton.Murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 14 TC 1 Z9 1 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD JUN PY 2010 VL 36 IS 4 BP 528 EP 532 DI 10.1016/j.burns.2009.07.006 PG 5 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 598RQ UT WOS:000277856300012 PM 19765906 ER PT J AU Zhou, J Enewold, L Stojadinovic, A Clifton, GT Potter, JF Peoples, GE Zhu, KM AF Zhou, Jing Enewold, Lindsey Stojadinovic, Alexander Clifton, Guy T. Potter, John F. Peoples, George E. Zhu, Kangmin TI Incidence rates of exocrine and endocrine pancreatic cancers in the United States SO CANCER CAUSES & CONTROL LA English DT Article DE Pancreatic cancer; Incidence rates; Epidemiology; SEER program ID FINE-NEEDLE-ASPIRATION; NEUROENDOCRINE TUMORS; ENDOSCOPIC ULTRASOUND; CIGARETTE-SMOKING; RISK-FACTORS; CARCINOID-TUMORS; DIAGNOSIS; TRENDS; EPIDEMIOLOGY; MANAGEMENT AB Descriptive studies of pancreatic cancer incidence have been sparse particularly in terms of tumor histology and stage. The purpose of this study was to examine the incidence rate trends of exocrine and endocrine pancreatic cancers by demographic and tumor characteristics using data from the Surveillance, Epidemiology, and End Results (SEER) program from 1977 to 2005. During this period, the incidence of exocrine pancreatic cancer generally decreased whereas the incidence of endocrine pancreatic cancer increased. This difference in trends by histology was evident across age, gender, and racial groups. It was also evident among different racial/ethnic groups using data from 1992 to 2005. Variation in trends was observed by stage. The incidence of exocrine cancers declined for all stages except regional. Endocrine cancer incidence increased for all tumor stages, and the increase was most prominent for localized tumors. When exocrine tumors were stratified by tumor subsite, the incidence of cancers in the tail and body regions increased while the incidence in other regions decreased. While better detection and classification of tumors through improved diagnostic procedures may be related to these changing trends, etiologic factors warrant study. C1 [Zhou, Jing; Enewold, Lindsey; Potter, John F.; Zhu, Kangmin] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. [Clifton, Guy T.; Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Zhu, KM (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Bldg 1,Suite A-109,6900 Georgia Ave,NW, Washington, DC 20307 USA. EM kangmin.zhu@amedd.army.mil FU United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Fundation for the Advancement of Military Medicine FX This research was supported by the United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Fundation for the Advancement of Military Medicine. NR 41 TC 24 Z9 28 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-5243 J9 CANCER CAUSE CONTROL JI Cancer Causes Control PD JUN PY 2010 VL 21 IS 6 BP 853 EP 861 DI 10.1007/s10552-010-9512-y PG 9 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 596UA UT WOS:000277709800007 PM 20182788 ER PT J AU Helm, SR AF Helm, Steven R. TI A Calculation of Expected Plant Frequency SO CASTANEA LA English DT Article ID BINOMIAL PROPORTION; PATTERNS; VEGETATION; DESERT AB A calculation is presented that converts plant frequency per plot size sampled to expected frequency per any plot size of interest so as to compare studies that used different plot sizes or to assess degrees of spatial randomness in individual studies that used multiple plot sizes. Expected frequency is exponentially related to measured frequency, being dependent on plot size of interest relative to plot size from which measured frequency was obtained. Expected frequency per plot size of interest (F(e)) may be expressed as F(e) = 1 - (1 - F(s))(r), where F(s) is measured frequency per plot size sampled and r is the ratio of plot size of interest to plot size sampled. The calculation assumes that plants are randomly distributed, or approximately so, and criteria for presence of plants in plots are consistent in studies being compared. C1 USA, Corps Engineers, Portland, OR 97208 USA. RP Helm, SR (reprint author), USA, Corps Engineers, POB 2946 CENWP PM E, Portland, OR 97208 USA. EM steve.r.helm@usace.army.mil NR 21 TC 1 Z9 1 U1 3 U2 3 PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL PI NEWBERRY PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST, NEWBERRY, SC 29108 USA SN 0008-7475 J9 CASTANEA JI Castanea PD JUN PY 2010 VL 75 IS 2 BP 226 EP 231 DI 10.2179/09-013.1 PG 6 WC Plant Sciences SC Plant Sciences GA 635LC UT WOS:000280655800006 ER PT J AU Cox, D AF Cox, Douglas TI ARCHIVES AND RECORDS IN ARMED CONFLICT: INTERNATIONAL LAW AND THE CURRENT DEBATE OVER IRAQI RECORDS AND ARCHIVES SO CATHOLIC UNIVERSITY LAW REVIEW LA English DT Article ID WORLD-WAR-II; UNITED-STATES; EUROPEAN ARCHIVES; NATIONAL ARCHIVES; CULTURAL PROPERTY; GERMAN RECORDS; DESTRUCTION; OCCUPATION; LIBRARIES; PROTECT C1 [Cox, Douglas] CUNY, Sch Law, New York, NY USA. [Cox, Douglas] USA, Washington, DC USA. RP Cox, D (reprint author), CUNY, Sch Law, New York, NY USA. NR 127 TC 0 Z9 0 U1 2 U2 4 PU CATHOLIC UNIV AMER PRESS PI WASHINGTON PA 620 MICHIGAN AVENUE NE ADMIN BLDG ROOM 303, WASHINGTON, DC 20064 USA SN 0008-8390 J9 CATHOL U LAW REV JI Cathol. Univ. Law Rev. PD SUM PY 2010 VL 59 IS 4 BP 1001 EP 1056 PG 56 WC Law SC Government & Law GA 663TY UT WOS:000282914000004 ER PT J AU Corron, NJ Blakely, JN Stahl, MT AF Corron, Ned J. Blakely, Jonathan N. Stahl, Mark T. TI A matched filter for chaos SO CHAOS LA English DT Article ID DIFFERENTIAL-EQUATIONS; COMMUNICATION; NOISE; SYSTEMS; SYNCHRONIZATION; HYSTERESIS; PERFORMANCE; DYNAMICS; SCHEMES AB A novel chaotic oscillator is shown to admit an exact analytic solution and a simple matched filter. The oscillator is a hybrid dynamical system including both a differential equation and a discrete switching condition. The analytic solution is written as a linear convolution of a symbol sequence and a fixed basis function, similar to that of conventional communication waveforms. Waveform returns at switching times are shown to be conjugate to a chaotic shift map, effectively proving the existence of chaos in the system. A matched filter in the form of a delay differential equation is derived for the basis function. Applying the matched filter to a received waveform, the bit error rate for detecting symbols is derived, and explicit closed-form expressions are presented for special cases. The oscillator and matched filter are realized in a low-frequency electronic circuit. Remarkable agreement between the analytic solution and the measured chaotic waveform is observed. [doi :10.1063/1.3432557] C1 [Corron, Ned J.; Blakely, Jonathan N.; Stahl, Mark T.] USA, Res Dev & Engn Command, RDMR WSS, Redstone Arsenal, AL 35898 USA. RP Corron, NJ (reprint author), USA, Res Dev & Engn Command, RDMR WSS, Redstone Arsenal, AL 35898 USA. EM ned.corron@us.army.mil OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 30 TC 34 Z9 34 U1 2 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1054-1500 J9 CHAOS JI Chaos PD JUN PY 2010 VL 20 IS 2 AR 023123 DI 10.1063/1.3432557 PG 10 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA 630WB UT WOS:000280304600023 PM 20590319 ER PT J AU Russell, AL Kennedy, AM Spuches, AM Venugopal, D Bhonsle, JB Hicks, RP AF Russell, Amanda L. Kennedy, Anthony M. Spuches, Anne M. Venugopal, Divakaramenon Bhonsle, Jayendra B. Hicks, Rickey P. TI Spectroscopic and thermodynamic evidence for antimicrobial peptide membrane selectivity SO CHEMISTRY AND PHYSICS OF LIPIDS LA English DT Article DE Antimicrobial peptide; Circular dichroism; Isothermal titration calorimetry; Calcein fluorescence leakage; Liposomes ID ISOTHERMAL TITRATION CALORIMETRY; MAGAININ 2 AMIDE; PORE FORMATION; PHOSPHOLIPID-MEMBRANES; AMPHIPATHIC PEPTIDES; GRAMICIDIN-S; BINDING; BILAYERS; LEAKAGE; MODEL AB In our laboratory we developed a series of antimicrobial peptides that exhibit selectivity and potency for prokaryotic over eukaryotic cells (Hicks et al., 2007). Circular dichroism (CD), isothermal calorimetry (ITC) and calcein leakage assays were conducted to determine the mechanism of lipid binding of a representative peptide 1 (Ac-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK-CONH2) to model membranes. POPC liposomes were used as a simple model for eukaryotic membranes and 4:1 POPC:POPG liposomes were used as a simple model for prokaryotic membranes. CD, ITC and calcein leakage data clearly indicate that compound 1 interacts via very different mechanisms with the two different liposome membranes. Compound 1 exhibits weaker binding and induces less calcein leakage in POPC liposomes than POPC:POPG (4:1 mole ratio) liposomes. The predominant binding mechanism to POPC appears to be limited to surface interactions while the mechanism of binding to 4:1 POPC:POPG most likely involves some type of pore formation. (C) 2010 Elsevier Ireland Ltd. All rights reserved. C1 [Russell, Amanda L.; Kennedy, Anthony M.; Spuches, Anne M.; Venugopal, Divakaramenon; Hicks, Rickey P.] E Carolina Univ, Dept Chem, Greenville, NC 27858 USA. [Bhonsle, Jayendra B.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Hicks, RP (reprint author), E Carolina Univ, Dept Chem, Sci & Technol Bldg,Suite 300, Greenville, NC 27858 USA. EM hicksr@ecu.edu OI Kennedy, Anthony/0000-0002-0908-3020 FU Defense Threat Reduction Agency [W81XWH-08-2-0095]; North Carolina Biotechnology Center [2006-FRG-1015]; East Carolina University FX The authors would like to acknowledge funding from the Bacterial Therapeutics Program 2.1 of the Defense Threat Reduction Agency. Contract # W81XWH-08-2-0095. The authors would also like to acknowledge funding from the North Carolina Biotechnology Center grant number 2006-FRG-1015 and from East Carolina University. NR 67 TC 27 Z9 28 U1 2 U2 22 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-3084 J9 CHEM PHYS LIPIDS JI Chem. Phys. Lipids PD JUN PY 2010 VL 163 IS 6 BP 488 EP 497 DI 10.1016/j.chemphyslip.2010.03.009 PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 627IU UT WOS:000280033500005 PM 20362562 ER PT J AU Olemukan, RE Eller, LA Ouma, BJ Etonu, B Erima, S Naluyima, P Kyabaggu, D Cox, JH Sandberg, JK Wabwire-Mangen, F Michael, NL Robb, ML de Souza, MS Eller, MA AF Olemukan, Robert E. Eller, Leigh Anne Ouma, Benson J. Etonu, Ben Erima, Simon Naluyima, Prossy Kyabaggu, Denis Cox, Josephine H. Sandberg, Johan K. Wabwire-Mangen, Fred Michael, Nelson L. Robb, Merlin L. de Souza, Mark S. Eller, Michael A. TI Quality Monitoring of HIV-1-Infected and Uninfected Peripheral Blood Mononuclear Cell Samples in a Resource-Limited Setting SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID HIV VACCINE TRIALS; CD8(+) T-CELLS; WHOLE-BLOOD; LYMPHOCYTE IMMUNOPHENOTYPE; PROLIFERATIVE RESPONSES; REFERENCE INTERVALS; CLINICAL-TRIALS; ELISPOT ASSAYS; RAKAI DISTRICT; FLOW-CYTOMETRY AB Human immunodeficiency virus type 1 (HIV-1) vaccine and natural history studies are critically dependent on the ability to isolate, cryopreserve, and thaw peripheral blood mononuclear cell (PBMC) samples with a high level of quality and reproducibility. Here we characterize the yield, viability, phenotype, and function of PBMC from HIV-1-infected and uninfected Ugandans and describe measures to ascertain reproducibility and sample quality at the sites that perform cryopreservation. We have developed a comprehensive internal quality control program to monitor processing, including components of method validation. Quality indicators for real-time performance assessment included the time from venipuncture to cryopreservation, time for PBMC processing, yield of PBMC from whole blood, and viability of the PBMC before cryopreservation. Immune phenotype analysis indicated lowered B-cell frequencies following processing and cryopreservation for both HIV-1-infected and uninfected subjects (P < 0.007), but all other major lymphocyte subsets were unchanged. Long-term cryopreservation did not impact function, as unstimulated specimens exhibited low background and all specimens responded to staphylococcal enterotoxin B (SEB) by gamma interferon and interleukin-2 production, as measured by intracellular cytokine staining. Samples stored for more than 3 years did not decay with regard to yield or viability, regardless of HIV-1 infection status. These results demonstrate that it is possible to achieve the high level of quality necessary for vaccine trials and natural history studies in a resource-limited setting and provide strategies for laboratories to monitor PBMC processing performance. C1 [Eller, Leigh Anne; Michael, Nelson L.; Robb, Merlin L.; de Souza, Mark S.; Eller, Michael A.] US Mil HIV Res Program, Rockville, MD 20850 USA. [Olemukan, Robert E.; Eller, Leigh Anne; Ouma, Benson J.; Etonu, Ben; Erima, Simon; Naluyima, Prossy; Kyabaggu, Denis; Wabwire-Mangen, Fred; Eller, Michael A.] Makerere Univ, Walter Reed Project, Kampala, Uganda. [Cox, Josephine H.] Int AIDS Vaccine Initiat, New York, NY USA. [Sandberg, Johan K.; Eller, Michael A.] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Med, Ctr Infect Med, S-14186 Stockholm, Sweden. [de Souza, Mark S.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Eller, MA (reprint author), US Mil HIV Res Program, 13 Taft Court,Suite 200, Rockville, MD 20850 USA. EM meller@hivresearch.org OI Sandberg, Johan/0000-0002-6275-0750 FU Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. [W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]; U.S. National Institute of Allergy and Infectious Diseases FX This work was supported by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). This research was funded in part by the U.S. National Institute of Allergy and Infectious Diseases. NR 47 TC 15 Z9 15 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 EI 1556-679X J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD JUN PY 2010 VL 17 IS 6 BP 910 EP 918 DI 10.1128/CVI.00492-09 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 603MG UT WOS:000278212100004 PM 20200187 ER PT J AU Anderson, SB Webb, MD Banks, KP AF Anderson, Shane B. Webb, Matthew D. Banks, Kevin P. TI Adrenal Collision Tumor Diagnosed by F-18 Fluorodeoxyglucose PET/CT SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE collision tumor; adrenal adenoma; adrenal metastasis; FDG; PET ID LESIONS; MASSES; GLAND; CT C1 [Anderson, Shane B.; Banks, Kevin P.] Brooke Army Med Ctr, Nucl Med Serv, Ft Sam Houston, TX 78234 USA. [Webb, Matthew D.; Banks, Kevin P.] Brooke Army Med Ctr, Dept Radiol, Ft Sam Houston, TX 78234 USA. RP Webb, MD (reprint author), Brooke Army Med Ctr, Dept Radiol & Nucl Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Matthew.Webb3@amedd.army.mil NR 9 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JUN PY 2010 VL 35 IS 6 BP 414 EP 417 DI 10.1097/RLU.0b013e3181db4df1 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 601YU UT WOS:000278105000007 PM 20479588 ER PT J AU Hanson, H Larson, M Kraus, NC AF Hanson, Hans Larson, Magnus Kraus, Nicholas C. TI Calculation of beach change under interacting cross-shore and longshore processes SO COASTAL ENGINEERING LA English DT Article DE Longshore sediment transport; Beach response; Groins; Coastal structures; Numerical modeling; Shoreline evolution; Dune erosion; Windblown sand ID EQUIVALENT ROUGHNESS HEIGHT; PLANE BED; SWASH; MODEL; FLOW AB This paper presents a mathematical approach and numerical model that simulates beach and dune change in response to cross-shore processes of dune growth by wind and dune erosion by storms, and by gradients in longshore sand transport that will alter shoreline position. Sub-aerial transport processes are represented, whereas sub-aqueous transport is neglected. The system is tightly coupled morphologically, with the berm playing a central role. For example, the potential for sand to be transported to the dune by wind depends on berm width, and sand lost in erosion of the dune during storms can widen the berm. Morphologic equilibrium considerations are introduced to improve reliability of predictions and stability of the non-linear model. An analytical solution is given under simplification to illustrate properties of the model. Sensitivity tests with the numerical solution of the coupled equations demonstrate model performance, with one test exploring beach and dune response to potential increase in storm-wave height with global warming. Finally, the numerical model is applied to examine the consequences of groin shortening at Westhampton Beach, Long Island, New York, as an alternative for providing a sand supply to the down-drift beach. Results indicate that the sand will be released over several decades as the shoreline and dune move landward in adjustment to the new equilibrium condition with the shortened groins. (C) 2010 Elsevier B.V. All rights reserved. C1 [Hanson, Hans; Larson, Magnus] Lund Univ, S-22100 Lund, Sweden. [Kraus, Nicholas C.] USA, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. RP Hanson, H (reprint author), Lund Univ, Box 118, S-22100 Lund, Sweden. EM hans.hanson@tvrl.lth.se NR 24 TC 11 Z9 12 U1 1 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD JUN PY 2010 VL 57 IS 6 BP 610 EP 619 DI 10.1016/j.coastaleng.2010.02.002 PG 10 WC Engineering, Civil; Engineering, Ocean SC Engineering GA 594NF UT WOS:000277543700007 ER PT J AU Glen, AG AF Glen, Andrew G. TI Accurate estimation with one order statistic SO COMPUTATIONAL STATISTICS & DATA ANALYSIS LA English DT Article DE Order statistics; Maximum likelihood; Type II right censoring; Computational probability ID FISHER INFORMATION AB Estimating parameters from certain survival distributions is shown to suffer little loss of accuracy in the presence of left censoring. The variance of maximum likelihood estimates (MLE) in the presence of type II right-censoring is almost un-degraded if there also is heavy left-censoring when estimating certain parameters. In fact, if only a single data point, the rth recorded failure time, is available, the MLE estimates using the one data point are similar in variance to the estimates using all r failure points for all but the most extreme values of r. Analytic results are presented for the case of the exponential and Rayleigh distributions, to include the exact distributions of the estimators for the parameters. Simulated results are also presented for the gamma distribution. Implications in life test design and cost savings are explained as a result. Also computational considerations for finding analytic results as well as simulated results in a computer algebra system are discussed. Published by Elsevier B.V. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Glen, AG (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM aa1275@usma.edu NR 15 TC 0 Z9 0 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9473 J9 COMPUT STAT DATA AN JI Comput. Stat. Data Anal. PD JUN 1 PY 2010 VL 54 IS 6 BP 1434 EP 1441 DI 10.1016/j.csda.2010.01.012 PG 8 WC Computer Science, Interdisciplinary Applications; Statistics & Probability SC Computer Science; Mathematics GA 581OV UT WOS:000276534500003 ER PT J AU Chen, L Wang, ZJ Szymanski, B Branch, JW Verma, D Damarla, R Ibbotson, J AF Chen, Lei Wang, Zijian Szymanski, Boleslaw Branch, Joel W. Verma, Dinesh Damarla, Raju Ibbotson, John TI Dynamic Service Execution in Sensor Networks SO COMPUTER JOURNAL LA English DT Article DE sensor networks; congestion management; target tracking; auctions AB Sensor networks face a number of challenges when deployed in unpredictable environments under dynamic, quickly changeable demands, and when shared by many partners, which is often the case in military and security applications. To partially address these challenges, we present a novel target tracking algorithm that can be deployed on various sensor nodes and invoked dynamically when needed by the presence of targets. We also demonstrate that an auction-based mechanism can be used to provide efficient and localized wireless sensor network congestion management for bursty traffic of abstract services based just on user-assigned priorities to different services and the quality of information provided by the services. We present results from using this auction mechanism to resolve congestion caused by packets from competing target tracking missions. C1 [Chen, Lei; Wang, Zijian; Szymanski, Boleslaw] Rensselaer Polytech Inst, Dept Comp Sci, Troy, NY 12180 USA. [Branch, Joel W.; Verma, Dinesh] IBM Watson Res Ctr, Hawthorne, NY USA. [Damarla, Raju] USA, Res Lab, Adelphi, MD USA. [Ibbotson, John] IBM Corp, Emerging Technol Serv, Winchester, Hants, England. RP Szymanski, B (reprint author), Rensselaer Polytech Inst, Dept Comp Sci, Troy, NY 12180 USA. EM szymab@rpi.edu RI Szymanski, Boleslaw/A-9121-2009 OI Szymanski, Boleslaw/0000-0002-0307-6743 FU US Army Research Laboratory; UK Ministry of Defence [W911NF-06-3-0001] FX This research was sponsored by US Army Research Laboratory and the UK Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. NR 21 TC 8 Z9 8 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0010-4620 EI 1460-2067 J9 COMPUT J JI Comput. J. PD JUN PY 2010 VL 53 IS 5 BP 513 EP 527 DI 10.1093/comjnl/bxp051 PG 15 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA 603SE UT WOS:000278227500004 ER PT J AU Verma, D Ko, BJ Zerfos, P Lee, KW He, T Duggan, M Stewart, K Swami, A Sofra, N AF Verma, Dinesh Ko, Bong Jun Zerfos, Petros Lee, Kang-won He, Ting Duggan, Matthew Stewart, Kristian Swami, Ananthram Sofra, Nikoletta TI Understanding the Quality of Monitoring for Network Management SO COMPUTER JOURNAL LA English DT Article DE network monitoring; quality of monitoring; network managenment AB The vitality and utility of a network are affected significantly by the network management system (NMS) that is used to administer and monitor the network. However, models that can characterize the quality of a NMS are generally missing in the literature. In this paper, we introduce the concept of quality of monitoring (QoM), provide a mathematical formulation based on stochastic processes that can be used to model a network monitoring system and define QoM metrics based on this formulation. A formal analysis of the proposed framework along various metrics is also provided, along with a case study of its application to network monitoring in a mobile ad hoc network. C1 [Verma, Dinesh; Ko, Bong Jun; Zerfos, Petros; Lee, Kang-won; He, Ting] IBM TJ Watson Res Ctr, Networking Technol, Hawthorne, NY 10532 USA. [Duggan, Matthew; Stewart, Kristian] IBM United Kingdom Ltd, London SE1 9PZ, England. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. [Sofra, Nikoletta] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England. RP Zerfos, P (reprint author), IBM TJ Watson Res Ctr, Networking Technol, 19 Skyline Dr, Hawthorne, NY 10532 USA. EM pzerfos@us.ibm.com FU US Army Research Laboratory; UK Ministry of Defence [W911NF-06-3-0001] FX This research was sponsored by the US Army Research Laboratory and the UK Ministry of Defence and was accomplished under agreement number W911NF-06-3-0001. NR 20 TC 2 Z9 2 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0010-4620 J9 COMPUT J JI Comput. J. PD JUN PY 2010 VL 53 IS 5 BP 541 EP 550 DI 10.1093/comjnl/bxp058 PG 10 WC Computer Science, Hardware & Architecture; Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA 603SE UT WOS:000278227500006 ER PT J AU Sauerwein, RW Bijker, EM Richie, TL AF Sauerwein, Robert W. Bijker, Else M. Richie, Thomas L. TI Empowering malaria vaccination by drug administration SO CURRENT OPINION IN IMMUNOLOGY LA English DT Review ID PLASMODIUM-FALCIPARUM; DENDRITIC CELLS; CHLOROQUINE TREATMENT; LIVER STAGE; IN-VIVO; IMMUNITY; VACCINES; RESPONSES; IMMUNOGENICITY; SPOROZOITES AB Although significant progress has been made in clinical development, a protective malaria vaccine remains elusive. Here we review some of the immune subversive mechanisms used by the Plasmodium malaria parasite and propose a potentially effective strategy to achieve complete protection that may serve as a blue print for clinical usage. The premise is to modulate the immune response with drugs that neutralize suppressive functions and potentiate protective responses. Chloroquine may be a first attractive candidate facilitating protective cellular immune responses by improving cross-presentation and reducing suppressive regulatory T cell responses. C1 [Sauerwein, Robert W.; Bijker, Else M.] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol 268, NL-6500 HB Nijmegen, Netherlands. [Richie, Thomas L.] USN, US Mil Malaria Vaccine Program, Infect Dis Directorate, Med Res Ctr,Walter Reed Army Inst Res, Silver Spring, MD USA. RP Sauerwein, RW (reprint author), Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol 268, POB 9101, NL-6500 HB Nijmegen, Netherlands. EM r.sauerwein@mmb.umcn.nl RI Sauerwein, Robert/C-8519-2013; OI Richie, Thomas/0000-0002-2946-5456 FU [6000.RAD1.F.A0309] FX The work of TLR was prepared as part of his official government duties as a military service member. Title 17 U.S.C. 105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member as part of that person's official duties. The work of TLR was supported by work unit number 6000.RAD1.F.A0309. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, the Department of Defense, or the U.S. Government. NR 36 TC 17 Z9 17 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0952-7915 J9 CURR OPIN IMMUNOL JI Curr. Opin. Immunol. PD JUN PY 2010 VL 22 IS 3 BP 367 EP 373 DI 10.1016/j.coi.2010.04.001 PG 7 WC Immunology SC Immunology GA 619JD UT WOS:000279425500016 PM 20434895 ER PT J AU Dees, RA Dabkowski, MF Parnell, GS AF Dees, Robert A. Dabkowski, Matthew F. Parnell, Gregory S. TI Decision-Focused Transformation of Additive Value Models to Improve Communication SO DECISION ANALYSIS LA English DT Article DE multiattribute value; decision analysis; common value; unavailable value; discriminatory value; decision-focused transformation AB When using multiobjective decision analysis with an additive value/utility model, we may define local ranges of the value measures that are bounded by the set of alternatives, or we can define global ranges of the value measures that are bounded by our preferences for some future set of alternatives. Local value models use the full value space defined by the alternatives to distinguish between the alternatives. Global value models may identify new objectives and may help us develop better alternatives, but the alternatives do not usually span the full global value space. We present a mathematical transformation of a global value model's single-dimensional value functions and swing weights to a decision-focused value model using the global value, alternative scores, and transformation equations. When the transformation is appropriate, the decision-focused value model can provide useful distinctions to better communicate the trade-offs between alternatives. We prove that the transformation preserves the rank ordering of the alternatives, and we discuss the appropriate conditions for use. C1 [Dees, Robert A.; Dabkowski, Matthew F.; Parnell, Gregory S.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. [Parnell, Gregory S.] Innovat Decis Inc, Vienna, VA 22182 USA. RP Dees, RA (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM rob.dees@us.army.mil; matthew.dabkowski@usma.edu; gregory.parnell@usma.edu NR 14 TC 7 Z9 7 U1 0 U2 5 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 1545-8490 J9 DECIS ANAL JI Decis. Anal. PD JUN PY 2010 VL 7 IS 2 BP 172 EP 184 DI 10.1287/deca.1090.0168 PG 13 WC Management SC Business & Economics GA 609WC UT WOS:000278687700003 ER PT J AU Jiang, L Hsu, A Chu, D Chen, R AF Jiang, Luhua Hsu, Andrew Chu, Deryn Chen, Rongrong TI A highly active Pd coated Ag electrocatalyst for oxygen reduction reactions in alkaline media SO ELECTROCHIMICA ACTA LA English DT Article DE Oxygen reduction reaction; Electrocatalyst; Pd; Carbon-supported silver; Alkaline media ID PLATINUM-MONOLAYER ELECTROCATALYSTS; MANGANESE OXIDE NANOPARTICLES; SINGLE-CRYSTAL SURFACES; ETHANOL ELECTROOXIDATION; O-2 REDUCTION; FUEL-CELLS; ELECTROCHEMICAL REDUCTION; ALLOY ELECTROCATALYSTS; CATALYTIC-ACTIVITY; DISK ELECTRODE AB We synthesized and characterized a highly active electrocatalyst for oxygen reduction reactions (ORRs) in alkaline media by coating carbon-supported silver nanoparticles with Pd (Pd@Ag/C) via a galvanic displacement method. The electrochemical measurements were carried out using an ultrathin film rotating disk electrode Compared to the Pt/C electrocatalyst, the specific and mass activities of the Pd@Ag/C were enhanced by a factor of 3 and 25. respectively. The potentiostatic measurements showed that the Pd@Ag/C is less stable than the Pt/C at the potential of -0 1 V vs. Hg/HgO/OH(-) in alkaline media The Pd@Ag/C is insensitive to alcohol, and, as a cathode electrocatalyst of a direct alcohol fuel cell, can resist poisoning by the possible alcohol crossover from the anode. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Jiang, Luhua; Hsu, Andrew; Chen, Rongrong] Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. [Chu, Deryn] Army Res Lab, Adelphi, MD 20783 USA. RP Chen, R (reprint author), Indiana Univ Purdue Univ, Richard G Lugar Ctr Renewable Energy, Indianapolis, IN 46202 USA. FU U.S. Army Research Lab [W911NF-07-2-0036] FX This work is partially supported by the U.S. Army Research Lab (Grant Number: W911NF-07-2-0036). The authors appreciate Prof. Dr. R.R. Adzic at Brookhaven National Laboratory for his helpful discussion. NR 74 TC 52 Z9 52 U1 4 U2 60 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-4686 J9 ELECTROCHIM ACTA JI Electrochim. Acta PD JUN 1 PY 2010 VL 55 IS 15 BP 4506 EP 4511 DI 10.1016/j.electacta.2010.02.094 PG 6 WC Electrochemistry SC Electrochemistry GA 610KC UT WOS:000278730400014 ER PT J AU Minami, NA Soto, LL Rhodes, DH AF Minami, Nathan A. Soto, Leticia L. Rhodes, Donna H. TI Dynamic Lean Management of the Naval Construction Process SO EMJ-ENGINEERING MANAGEMENT JOURNAL LA English DT Article DE Construction Management; System Dynamics; Process Improvement; Constructability; Simulation AB The naval and private construction industries face shared problems in regard to cost over-runs and delays that may be addressed in part through improvements to the construction process. The scope of this study is to examine the naval construction process from design to implementation, with special emphasis on the role of design sharing and constructability. We use the System Dynamics methodology to model the construction process and conduct simulations to examine the impact of project management decisions. We conclude that increased constructability efforts and design sharing mitigate the impact of cost over-runs and project completion delays, and that when limited resources exist it is best to focus improvement efforts early rather than later. C1 [Minami, Nathan A.] USA, West Point, NY USA. [Soto, Leticia L.] USN, Arlington, VA USA. [Rhodes, Donna H.] MIT, Lean Aerosp Initiat, Engn Syst Div, Cambridge, MA 02139 USA. RP Minami, NA (reprint author), 6613A Falcon Dr, Ft Drum, NY 13603 USA. EM nathan.minami@us.army.mil NR 15 TC 3 Z9 3 U1 2 U2 11 PU AMER SOC ENGINEERING MANAGEMENT PI ROLLA PA PO BOX 820, ROLLA, MO 65402 USA SN 1042-9247 J9 EMJ-ENG MANAG J JI EMJ-Eng. Manag. J. PD JUN PY 2010 VL 22 IS 2 BP 36 EP 43 PG 8 WC Engineering, Industrial; Management SC Engineering; Business & Economics GA V24BC UT WOS:000208384900006 ER PT J AU Auchus, RJ Wichel, S White, PC Baker, LA Baratz, A Berebaum, SA Eugster, EA Geffner, ME Loechner, KJ Merke, D Nenadovich, T Poppas, DP Riepe, FG Rink, R Rivkees, SA Sandberg, DE Schaeffer, T Schlussel, RN VanRyzin, C Vogiatzi, MG Aisenberg, JE Bachega, T Lee, PA Miller, WL Quigley, CA Seely, E Azziz, R Fracassa, S Leight, K Lin, GA Snyder, D Matos, DM Schneck, FX Katz, AL Pass, K Lloyd-Puryear, MA Breault, D Kalro, B Harris, KB Therrell, BL AF Auchus, Richard J. Wichel, Selma White, Perrin C. Baker, Linda A. Baratz, Arlene Berebaum, Sheri A. Eugster, Erica A. Geffner, Mitchell E. Loechner, Karen J. Merke, Deborah Nenadovich, Tamara Poppas, Dix P. Riepe, Felix G. Rink, Richard Rivkees, Scott A. Sandberg, David E. Schaeffer, Traci Schlussel, Richard N. VanRyzin, Carol Vogiatzi, Maria G. Aisenberg, Javier E. Bachega, Tania Lee, Peter A. Miller, Walter L. Quigley, Charmian A. Seely, Ellen Azziz, Ricardo Fracassa, Stephanie Leight, Kelly Lin, Gretchen A. Snyder, Diane Matos, Dina M. Schneck, Francis X. Katz, Aviva L. Pass, Kenneth Lloyd-Puryear, Michele A. Breault, David Kalro, Brinda Harris, Katharine B. Therrell, Bradley L. CA CAH CCC Comm TI Development of Comprehensive Care Centers for Management of Patients with Congenital Adrenal Hyperplasia. SO ENDOCRINE REVIEWS LA English DT Meeting Abstract CT 92nd Meeting and Expo of the Endocrine Society (ENDO 2010) CY JUN 19-22, 2010 CL San Diego, CA SP Endocrine Society C1 [Auchus, Richard J.; White, Perrin C.; Baker, Linda A.] UT SW Med Ctr, Dallas, TX USA. [Wichel, Selma; Nenadovich, Tamara; Schneck, Francis X.] Univ Pittsburgh, Childrens Hosp Pittsburgh, Med Ctr, Pittsburgh, PA 15213 USA. [Baratz, Arlene] USA, Androgen Insensit Syndrome Support Grp, Duncan, OK USA. [Berebaum, Sheri A.] Penn State Univ, University Pk, PA 16802 USA. [Eugster, Erica A.; Rink, Richard] Indiana Univ Sch Med, Indianapolis, IN USA. [Geffner, Mitchell E.] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA. [Loechner, Karen J.] Univ N Carolina, Chapel Hill, NC USA. [Merke, Deborah; VanRyzin, Carol] NIH, Ctr Clin, Bethesda, MD 20892 USA. [Harris, Katharine B.] NYS Genet Serv Program, Albany, NY USA. [Poppas, Dix P.; Vogiatzi, Maria G.] Weill Cornell Med Coll, New York, NY USA. [Riepe, Felix G.] Univ Hosp Schleswig Holstein, Kiel, Germany. [Rivkees, Scott A.] Yale Univ, Sch Med, New Haven, CT USA. [Sandberg, David E.] Univ Michigan, Ann Arbor, MI 48109 USA. [Schaeffer, Traci] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA. [Schlussel, Richard N.] Columbia Univ, Med Ctr, New York, NY USA. [Aisenberg, Javier E.] Hackensack Univ, Med Ctr, Hackensack, NJ USA. [Bachega, Tania] Univ Sao Paulo, Sao Paulo, Brazil. [Lee, Peter A.] Penn State Milton S Hershey Med Ctr, Hershey, PA USA. [Miller, Walter L.] Univ Calif San Francisco, San Francisco, CA 94143 USA. [Quigley, Charmian A.] Eli Lilly & Co, Indianapolis, IN 46285 USA. [Seely, Ellen] Brigham & Womens Hosp, Boston, MA 02115 USA. [Azziz, Ricardo] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA. [Fracassa, Stephanie; Leight, Kelly; Lin, Gretchen A.; Matos, Dina M.; CAH CCC Comm] Congenital Adrenal Hyperplasia Res Educ & Support, Union, NJ USA. [Katz, Aviva L.] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA. [Pass, Kenneth] New York State Dept Hlth, Albany, NY USA. [Lloyd-Puryear, Michele A.] US Hlth Resources & Serv Adm, Rockville, MD USA. [Breault, David] Childrens Hosp Boston, Boston, MA USA. [Kalro, Brinda] Univ Pittsburgh, Magee Womens Hosp, Pittsburgh, PA 15213 USA. [Snyder, Diane] Womens Hlth Specialists, Rockville, MD USA. [Therrell, Bradley L.] UT Hlth Scis Ctr, San Antonio, TX USA. RI Miller, Walter/J-3696-2012; Bachega, Tania/C-3361-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0163-769X J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2010 VL 31 IS 3 SU 1 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 652FV UT WOS:000281989403722 ER PT J AU Larson, NS Amin, R Olsen, C Poth, MA AF Larson, N. S. Amin, R. Olsen, C. Poth, M. A. TI Effect of Diet Cola on Urine Calcium Excretion. SO ENDOCRINE REVIEWS LA English DT Meeting Abstract CT 92nd Meeting and Expo of the Endocrine Society (ENDO 2010) CY JUN 19-22, 2010 CL San Diego, CA SP Endocrine Society C1 [Larson, N. S.; Amin, R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Olsen, C.; Poth, M. A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0163-769X J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2010 VL 31 IS 3 SU 1 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 652FV UT WOS:000281989402198 ER PT J AU McIver, HK Olsen, C Bednarek, JM Poth, MA AF McIver, H. K. Olsen, C. Bednarek, J. M. Poth, M. A. TI Autonomic Dysfunction in Obese Adolescents: Another Route to Cardiovascular Morbidity?. SO ENDOCRINE REVIEWS LA English DT Meeting Abstract CT 92nd Meeting and Expo of the Endocrine Society (ENDO 2010) CY JUN 19-22, 2010 CL San Diego, CA SP Endocrine Society C1 [McIver, H. K.; Bednarek, J. M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Olsen, C.; Poth, M. A.] Uniformed Serv Univ Hlth Scis, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0163-769X J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2010 VL 31 IS 3 SU 1 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 652FV UT WOS:000281989402721 ER PT J AU McIver, HK Rothwell, SW Eidelman, O Ayika, C Pollard, H Poth, MA AF McIver, H. K. Rothwell, S. W. Eidelman, O. Ayika, C. Pollard, H. Poth, M. A. TI Distinct Serum Proteome Profile in Obese Adolescents Females with Metabolic Syndrome. SO ENDOCRINE REVIEWS LA English DT Meeting Abstract CT 92nd Meeting and Expo of the Endocrine Society (ENDO 2010) CY JUN 19-22, 2010 CL San Diego, CA SP Endocrine Society C1 [McIver, H. K.; Poth, M. A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rothwell, S. W.; Eidelman, O.; Ayika, C.; Pollard, H.] Uniformed Serv Univ Hlth Scis, Bethesda, MD USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0163-769X J9 ENDOCR REV JI Endocr. Rev. PD JUN PY 2010 VL 31 IS 3 SU 1 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 652FV UT WOS:000281989402722 ER PT J AU Kaunda, RB Chase, RB Kehew, AE Kaugars, K Selegean, JP AF Kaunda, Rennie B. Chase, Ronald B. Kehew, Alan E. Kaugars, Karlis Selegean, James P. TI Neural network modeling applications in active slope stability problems SO ENVIRONMENTAL EARTH SCIENCES LA English DT Article DE Artificial neural network; Geotechnic; Slope stability; Earthflow; Lake Michigan ID FINITE-ELEMENTS; FAILURE; PROPAGATION; LANDSLIDES; DERBYSHIRE AB A back propagation artificial neural network approach is applied to three common challenges in engineering geology: (1) characterization of subsurface geometry/position of the slip (or failure surface) of active landslides, (2) assessment of slope displacements based on ground water elevation and climate, and (3) assessment of groundwater elevations based on climate data. Series of neural network models are trained, validated, and applied to a landslide study along Lake Michigan and cases from the literature. The subsurface characterization results are also compared to a limit equilibrium circular failure surface search with specific adopted boundary conditions. It is determined that the neural network models predict slip surfaces better than the limit equilibrium slip surface search using the most conservative criteria. Displacements and groundwater elevations are also predicted fairly well, in real time. The models' ability to predict displacements and groundwater elevations provides a foundational framework for building future warning systems with additional inputs. C1 [Kaunda, Rennie B.; Chase, Ronald B.; Kehew, Alan E.] Western Michigan Univ, Dept Geosci, Kalamazoo, MI 49008 USA. [Kaugars, Karlis] Western Michigan Univ, Dept Comp Sci, Kalamazoo, MI 49008 USA. [Selegean, James P.] USA, Corps Engineers, Great Lakes Hydraul & Hydrol Off, Detroit, MI 48226 USA. RP Kaunda, RB (reprint author), Western Michigan Univ, Dept Geosci, Kalamazoo, MI 49008 USA. EM renniek@hotmail.com FU US Army Corps of Engineers Engineering Research and Development Center (ERDC); Detroit District USACE; Western Michigan University FX We wish to acknowledge funding for the field studies from the US Army Corps of Engineers Engineering Research and Development Center (ERDC), and the Detroit District USACE. Western Michigan University provided both financial and logistical support. We are grateful to the property owners in Allegan County, MI, Allegan County Road Commission, and State of Michigan for granting access to the study site. Three anonymous reviewers provided helpful comments and suggestions. We also thank Dr. William Sauck, Department of Geosciences for reviewing the manuscript. NR 35 TC 14 Z9 15 U1 1 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1866-6280 J9 ENVIRON EARTH SCI JI Environ. Earth Sci. PD JUN PY 2010 VL 60 IS 7 BP 1545 EP 1558 DI 10.1007/s12665-009-0290-3 PG 14 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA 600AP UT WOS:000277956000020 ER PT J AU Gironas, J Roesner, LA Rossman, LA Davis, J AF Gironas, Jorge Roesner, Larry A. Rossman, Lewis A. Davis, Jennifer TI A new applications manual for the Storm Water Management Model (SWMM) SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Software Review DE SWMM; Application manual; Stormwater; Urban drainage; Computer model AB The EPA Storm Water Management Model (SWMM) is a widely used program for simulating urban runoff quantity and quality. Its existing documentation includes a User's Manual that describes how to run the program and a Reference Manual that covers its theory and algorithms. A new manual, the "SWMM Applications Manual", has been added to this collection. It contains nine worked-out examples addressing common stormwater management and design problems encountered in practice. The manual will be especially useful for new SWMM users who need additional guidance in applying this powerful tool to urban drainage design and analysis. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Gironas, Jorge] Pontificia Univ Catolica Chile, Dept Ingn Hidraul & Ambiental, Santiago, Chile. [Roesner, Larry A.] Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. [Rossman, Lewis A.] US EPA, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA. [Davis, Jennifer] US Army Corps Engineers, Hydrol Engn Branch, Hydrol Sect, Omaha, NE 68102 USA. RP Gironas, J (reprint author), Pontificia Univ Catolica Chile, Dept Ingn Hidraul & Ambiental, Av Vicuna Mackenna 4860, Santiago, Chile. EM jgironas@ing.puc.cl RI Gironas, Jorge/F-8297-2013 OI Gironas, Jorge/0000-0002-6933-2658 NR 3 TC 33 Z9 39 U1 11 U2 78 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD JUN PY 2010 VL 25 IS 6 BP 813 EP 814 DI 10.1016/j.envsoft.2009.11.009 PG 2 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA 574YO UT WOS:000276030300014 ER PT J AU Rosen, G Lotufo, GR AF Rosen, Gunther Lotufo, Guilherme R. TI FATE AND EFFECTS OF COMPOSITION B IN MULTISPECIES MARINE EXPOSURES SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE Composition B; TNT; RDX; Explosive; Marine sediment ID AMPHIPOD EOHAUSTORIUS-ESTUARIUS; IN-SITU; MYTILUS-GALLOPROVINCIALIS; PROCESS DESCRIPTORS; EXPLOSIVE COMPOUNDS; TOXICITY; 2,4,6-TRINITROTOLUENE; SEDIMENT; WATER; TNT AB The vast majority of investigations into the bioavailability and toxicity of explosives to receptors in aquatic environments has focused on deriving toxicity metrics for discrete chemical exposures to single species using pure compounds at relatively high concentrations. This study assessed the environmental fate and potential for biological effects of a common military formulation, Composition B, under more realistic exposure scenarios (e.g., those that more closely simulate a breached artillery round or residual exposure following a low-order detonation). We used a novel approach incorporating multiple species and toxicity endpoints in sediment exposures over a 34-d exposure period. Composition B fragments exposed at the sediment surface rapidly released 2,4,6-trinitrotolune (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) to the overlying water column. In comparison, burial of fragments resulted in dramatically reduced exposure, bioconcentration, and toxicity. The addition of a conservative flow rate to the aquaria also reduced water and tissue concentrations by factors of two to three. Although the exposure system likely represented a worst-case scenario relative to most conditions found in coastal and estuarine environments, overlying water concentrations generally did not approach known toxicity thresholds, while porewater concentrations were sufficiently elevated above toxicity thresholds immediately adjacent to the fragments, limiting hazardous exposure only to very localized scales. Bioconcentration correlated closely with observed toxicity and was either not detectable (buried), or low (exposed), as is expected based on the low hydrophobicities of TNT and RDX. Environ. Toxicol. Chem. 2010;29:1330-1337. (C) 2010 SETAC C1 [Rosen, Gunther] Space & Naval Warfare Syst Ctr Pacific, San Diego, CA 92152 USA. [Lotufo, Guilherme R.] USA, Corps Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Rosen, G (reprint author), Space & Naval Warfare Syst Ctr Pacific, San Diego, CA 92152 USA. EM gunther.rosen@navy.mil FU U.S. Navy's Environmental Sustainability Development; U.S. Army Corps of Engineers FX The U.S. Navy's Environmental Sustainability Development to Integration Program and the Installation Restoration Research Program of the U.S. Army Corps of Engineers supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N45) and the Chief of Engineers. The authors thank Daniel Farrar for high-performance liquid chromatography analyses, and William Blackburn, Cory McNemar, Jessica Coleman, Alfreda Gibson, Sandra Brasfield, and Jerre Sims for assistance in the laboratory. We also thank Bill Wild. Robert George. Barbara Sugiyama, and G. Allen Burton for reviews of the article. NR 32 TC 7 Z9 7 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUN PY 2010 VL 29 IS 6 BP 1330 EP 1337 DI 10.1002/etc.153 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 629VA UT WOS:000280226800017 PM 20821576 ER PT J AU Lyons, WB Goldsmith, ST Deuerling, KM Hannah, LM Harmon, RS AF Lyons, W. B. Goldsmith, S. T. Deuerling, K. M. Hannah, L. M. Harmon, R. S. TI Riverine chemical fluxes vs. long-term weathering, Central Panama SO GEOCHIMICA ET COSMOCHIMICA ACTA LA English DT Meeting Abstract CT Conference on Goldschmidt 2010 - Earth, Energy, and the Environment CY JUN 13-18, 2010 CL Knoxville, TN C1 [Lyons, W. B.; Goldsmith, S. T.; Deuerling, K. M.; Hannah, L. M.] Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA. [Lyons, W. B.; Goldsmith, S. T.; Deuerling, K. M.; Hannah, L. M.] Ohio State Univ, Byrd Polar Res Ctr, Columbus, OH 43210 USA. ARL Army Res Off, Div Environm Sci, Res Triangle Pk, NC 27709 USA. EM lyons.142@osu.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-7037 J9 GEOCHIM COSMOCHIM AC JI Geochim. Cosmochim. Acta PD JUN PY 2010 VL 74 IS 12 SU 1 BP A648 EP A648 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 676TL UT WOS:000283941401865 ER PT J AU Watson, S AF Watson, Samuel TI Class and Race in the Frontier Army Military Life in the West, 1870-1890 SO GREAT PLAINS QUARTERLY LA English DT Book Review C1 [Watson, Samuel] US Mil Acad, Dept Hist, West Point, NY 10996 USA. RP Watson, S (reprint author), US Mil Acad, Dept Hist, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CENT GREAT PLAINS STUD PI LINCOLN PA UNIV NEBRASKA-LINCOLN 1214 OLDFATHER HALL, LINCOLN, NE 68588-0313 USA SN 0275-7664 J9 GREAT PLAINS QUART JI Gt. Plains Q. PD SUM PY 2010 VL 30 IS 3 BP 227 EP 227 PG 1 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA 640ZN UT WOS:000281093000011 ER PT J AU Muza, SR Beidleman, BA Fulco, CS AF Muza, Stephen R. Beidleman, Beth A. Fulco, Charles S. TI Altitude Preexposure Recommendations for Inducing Acclimatization SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article DE altitude acclimatization; acute mountain sickness; high altitude ID ACUTE MOUNTAIN-SICKNESS; EXERCISE PERFORMANCE; SEA-LEVEL; VENTILATORY RESPONSE; SIMULATED ALTITUDE; HYPOXIC EXERCISE; ACETAZOLAMIDE; EXPOSURES; ILLNESS; 4,300-M AB Muza, Stephen R., Beth A. Beidleman, and Charles S Fuco. Altitude preexposure recommendations for inducing acclimatization. High Alt. Med.Biol. 11:87-92, 2010.-For many low-altitude (<500 m) residents, their travel itineraries may cause them to ascend rapidly to high (> 2400 m) altitudes without having the time to develop an adequate degree of altitude acclimatization. Prior to departing on these trips, low-altitude residents can induce some degree of altitude acclimatization by ascending to moderate (> 1500 m) or high altitudes during either continuous or intermittent altitude preexposures. Generally, the degree of altitude acclimatization developed is proportional to the altitude attained and the duration of exposure. The available evidence suggests that continuous residence at 2200m or higher for 1 to 2 days or daily 1.5- to 4-h exposures to > 4000m induce ventilatory acclimatization. Six days at 2200m substantially decreases acute mountain sickness (AMS) and improves work performance after rapid ascent to 4300 m. There is evidence that 5 or more days above 3000m within the last 2 months will significantly decrease AMS during a subsequent rapid ascent to 4500 m. Exercise training during the altitude preexposures may augment improvement in physical performance. The persistence of altitude acclimatization after return to low altitude appears to be proportional to the degree of acclimatization developed. The subsequent ascent to high altitude should be scheduled as soon as possible after the last altitude preexposure. C1 [Muza, Stephen R.; Beidleman, Beth A.; Fulco, Charles S.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Muza, SR (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Stephen.muza@us.army.mil NR 56 TC 34 Z9 40 U1 2 U2 12 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD JUN PY 2010 VL 11 IS 2 BP 87 EP 92 DI 10.1089/ham.2010.1006 PG 6 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 618BQ UT WOS:000279326600002 PM 20586592 ER PT J AU Baggish, AL Fulco, CS Muza, S Rock, PB Beidleman, B Cymerman, A Yared, K Fagenholz, P Systrom, D Wood, MJ Weyman, AE Picard, MH Harris, NS AF Baggish, Aaron L. Fulco, Charles S. Muza, Stephen Rock, Paul B. Beidleman, Beth Cymerman, Allen Yared, Kibar Fagenholz, Peter Systrom, David Wood, Malissa J. Weyman, Arthur E. Picard, Michael H. Harris, N. Stuart TI The Impact of Moderate-Altitude Staging on Pulmonary Arterial Hemodynamics after Ascent to High Altitude SO HIGH ALTITUDE MEDICINE & BIOLOGY LA English DT Article DE pulmonary circulation; pulmonary hypertension; pulmonary arterial pressure; high altitude; moderate altitude ID ACUTE MOUNTAIN-SICKNESS; VASCULAR-RESPONSE; CHRONIC HYPOXIA; CARDIAC-OUTPUT; RAT LUNG; EDEMA; HYPERTENSION; PRESSURE; OXYGEN; VASOCONSTRICTION AB Baggish, Aaron L., Charles S. Fulco, Stephen Muza, Paul B. Rock, Beth Beidleman, Allen Cymerman, Kibar Yared, Peter Fagenholz, David Systrom, Malissa J. Wood, Arthur E. Weyman, Michael H. Picard, and N. Stuart Harris The impact of moderate altitude on pulmonary arterial hemodynamics after ascent to high altitude. High Alt. Med. Biol. 11:139-145, 2010.-Staged ascent ( SA), temporary residence at moderate altitude en route to high altitude, reduces the incidence and severity of noncardiopulmonary altitude illness such as acute mountain sickness. To date, the impact of SA on pulmonary arterial pressure ( PAP) is unknown. We tested the hypothesis that SA would attenuate the PAP increase that occurs during rapid, direct ascent ( DA). Transthoracic echocardiography was used to estimate mean PAP in 10 healthy males at sea level (SL, P(B) approximate to 760 torr), after DA to simulated high altitude ( hypobaric chamber, PB approximate to 460 torr), and at 2 times points ( 90min and 4 days) during exposure to terrestrial high altitude ( PB approximate to 460 torr) after SA ( 7 days, moderate altitude, PB approximate to 548 torr). Alveolar oxygen pressure ( Pao(2)) and arterial oxygenation saturation ( Sao(2)) were measured at each time point. Compared to mean PAP at SL ( mean +/- SD, 14 +/- 3mmHg), mean PAP increased after DA to 37 +/- 8mmHg (Delta=24 +/- 10mmHg, p< 0.001) and was negatively correlated with both Pao(2) (r(2)=0.57, p=0.011) and Sao(2) (r(2)=0.64, p=0.005). In comparison, estimated mean PAP after SA increased to only 25 +/- 4mmHg (Delta=11 +/- 6mmHg, p< 0.001), remained unchanged after 4 days of high altitude residence (24 +/- 5mmHg, p not significant, or NS), and did not correlate with either parameter of oxygenation. SA significantly attenuated the PAP increase associated with continuous direct ascent to high altitude and appeared to uncouple PAP from both alveolar hypoxia and arterial hypoxemia. C1 [Baggish, Aaron L.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Fulco, Charles S.; Muza, Stephen; Beidleman, Beth; Cymerman, Allen] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Rock, Paul B.] Oklahoma State Univ, Ctr Hlth Serv, Tulsa, OK USA. RP Baggish, AL (reprint author), Massachusetts Gen Hosp, Div Cardiol, Yawkey Bldg,Suite 5B,55 Fruit St, Boston, MA 02114 USA. EM abaggish@partners.org OI Systrom, David/0000-0002-9610-6330; Picard, Michael/0000-0002-9264-3243 FU Center for Integration of Medicine and Innovative Technology (CIMIT), Boston, Massachusetts; U.S. Army Medical Research and Material Command [ATO IV.MD.2006.01] FX The study was supported in part by a project grant from the Center for Integration of Medicine and Innovative Technology (CIMIT), Boston, Massachusetts, and funding provided by the U.S. Army Medical Research and Material Command ATO IV.MD.2006.01. NR 30 TC 9 Z9 9 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1527-0297 J9 HIGH ALT MED BIOL JI High Alt. Med. Biol. PD JUN PY 2010 VL 11 IS 2 BP 139 EP 145 DI 10.1089/ham.2009.1073 PG 7 WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences GA 618BQ UT WOS:000279326600008 PM 20586598 ER PT J AU Crane, C AF Crane, Conrad TI Crossroads of Intervention: Insurgency and Counterinsurgency Lessons from Central America. SO HISTORIAN LA English DT Book Review C1 [Crane, Conrad] USA, War Coll, Washington, DC 20310 USA. RP Crane, C (reprint author), USA, War Coll, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0018-2370 J9 HISTORIAN JI Historian PD SUM PY 2010 VL 72 IS 2 BP 431 EP 432 PG 2 WC History SC History GA 607QP UT WOS:000278521700026 ER PT J AU Rovira, E Parasuraman, R AF Rovira, Ericka Parasuraman, Raja TI Transitioning to Future Air Traffic Management: Effects of Imperfect Automation on Controller Attention and Performance SO HUMAN FACTORS LA English DT Article DE trust; NextGen; automation; eye movement; air traffic management; air traffic control ID RELIABILITY; WORKLOAD; WARNINGS; RELIANCE; SYSTEMS; TRUST; MODEL AB Objective: This study examined whether benefits of conflict probe automation would occur in a future air traffic scenario in which air traffic service providers (ATSPs) are not directly responsible for freely maneuvering aircraft but are controlling other nonequipped aircraft (mixed-equipage environment). The objective was to examine how the type of automation imperfection (miss vs. false alarm) affects ATSP performance and attention allocation. Background: Research has shown that the type of automation imperfection leads to differential human performance costs. Method: Participating in four 30-min scenarios were 12 full-performance-level ATSPs. Dependent variables included conflict detection and resolution performance, eye movements, and subjective ratings of trust and self confidence. Results: ATSPs detected conflicts faster and more accurately with reliable automation, as compared with manual performance. When the conflict probe automation was unreliable, conflict detection performance declined with both miss (25% conflicts detected) and false alarm automation (50% conflicts detected). Conclusion: When the primary task of conflict detection was automated, even highly reliable yet imperfect automation (miss or false alarm) resulted in serious negative effects on operator performance. Application: The further in advance that conflict probe automation predicts a conflict, the greater the uncertainty of prediction; thus, designers should provide users with feedback on the state of the automation or other tools that allow for inspection and analysis of the data underlying the conflict probe algorithm. C1 [Parasuraman, Raja] George Mason Univ, Arch Lab, Fairfax, VA 22030 USA. RP Rovira, E (reprint author), US Mil Acad, 267C Thayer Hall Engn Psychol,MADN BS&L,646 Swif, West Point, NY 10996 USA. EM Ericka.Rovira@usma.edu FU National Aeronautics and Space Administration (NASA) Langley Research Center [GSRPORG 364230] FX This work was supported by Grant GSRPORG 364230 from the National Aeronautics and Space Administration (NASA) Langley Research Center. The views expressed in this work are those of the authors and do not necessarily reflect official U.S. Army or NASA policy. Many thanks to the controllers who participated in the study and to colleagues who supported fruitful discussion: Ulla Metzger, Marla Zinni, Peter Squire, and Reshma Kumar. Last, thanks to Xiong Jiang for programming the air traffic management simulation. NR 35 TC 12 Z9 14 U1 5 U2 14 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD JUN PY 2010 VL 52 IS 3 BP 411 EP 425 DI 10.1177/0018720810375692 PG 15 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 669CA UT WOS:000283322800004 PM 21077563 ER PT J AU Bedair, SS Meyer, CD Morgan, B AF Bedair, Sarah S. Meyer, Christopher D. Morgan, Brian TI Magnetic Nanoparticle Dosing of MEMS Structures by Solvent Evaporation in Capillaries SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article DE Inductor core; magnetic MEMS; nanoparticle arrays; patterned magnetics; self-assembly ID SILICON AB This paper describes a low cost method to deliver magnetic nanoparticle materials using a liquid suspension deposition into mu m-sized structures that would comprise an inductor core. The delivery structure consists of a well and capillary where the well is the target for liquid delivery. Prior theory describing the dosing of MEMS capillaries with polymers is extended to NiFe(2)O(4) nanoparticles in suspension for dosing capillaries constituting inductor type passives with similar to 200 times larger volumes (2 mm x 15 m x 10 m). Well and capillary structures were dosed with the magnetic nanoparticles suspension with and without the presence of a permanent magnetic field. Magnetization measurements show a difference in relative permeabilities of 4.2 and 3.3 with and without the presence of the magnetic field, respectively. C1 [Bedair, Sarah S.; Meyer, Christopher D.; Morgan, Brian] USA, Res Lab, Adelphi, MD 20783 USA. [Meyer, Christopher D.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. RP Bedair, SS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM sarahbedair@gmail.com RI Bedair, Sarah/D-9130-2013 NR 11 TC 3 Z9 3 U1 1 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JUN PY 2010 VL 46 IS 6 BP 2198 EP 2201 DI 10.1109/TMAG.2010.2044872 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 601DH UT WOS:000278037800239 ER PT J AU Meyer, CD Bedair, SS Morgan, BC Arnold, DP AF Meyer, Christopher D. Bedair, Sarah S. Morgan, Brian C. Arnold, David P. TI High-Inductance-Density, Air-Core, Power Inductors, and Transformers Designed for Operation at 100-500 MHz SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article DE Inductors; measurement; micromachining; power transformers ID TECHNOLOGY AB This paper presents the microfabrication and measurement of high-inductance-density, moderate-Q, air-core inductors, and transformers intended for switch-mode power supplies operating in the 100-500 MHz frequency range. The inductors and transformers were fabricated on Pyrex substrates with four layers of electrodeposited copper with each layer up to 10 mu m thick. Stacked winding layers allowed for mutual coupling between layers to increase areal inductance density. Inductors of various designs exhibited inductance densities of up to 100 nH/mm(2) and quality factors approaching 20 in the frequency range of interest. Transformers were formed by interleaving primary and secondary coils and were designed with increased inductance in the secondary coil for voltage gain. A fabricated transformer, 1.5 mm x 1.5 mm in area, yielded 46 nH primary inductance and 500 nH secondary inductance with a coupling coefficient of 0.63. Measurements indicated that a maximum transformer efficiency of 78% at 125 MHz would be possible. C1 [Meyer, Christopher D.; Arnold, David P.] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. [Meyer, Christopher D.; Bedair, Sarah S.; Morgan, Brian C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Meyer, CD (reprint author), Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. EM toph@ufl.edu RI Bedair, Sarah/D-9130-2013; Arnold, David/F-5947-2013 FU U.S. Army Research Laboratory [W911NF-08-2-0035] FX This work was supported by the U.S. Army Research Laboratory under Agreement W911NF-08-2-0035. NR 13 TC 42 Z9 42 U1 0 U2 9 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JUN PY 2010 VL 46 IS 6 BP 2236 EP 2239 DI 10.1109/TMAG.2010.2045742 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 601DH UT WOS:000278037800249 ER PT J AU Davis, J Smyth, C McDowell, K AF Davis, James Smyth, Christopher McDowell, Kaleb TI The Effects of Time Lag on Driving Performance and a Possible Mitigation SO IEEE TRANSACTIONS ON ROBOTICS LA English DT Article DE Indirect-vision driving; lag; predictive display ID DELAY; ADAPTATION AB Fixed time lags within control systems are known to reduce the speed and accuracy of human-control actions. Further, the effects of variable time lags are not well-studied or understood but may exacerbate the negative effects associated with fixed time lags. Several studies have demonstrated mechanisms designed to combat the effects of time lag, which include adaptation, mathematical predictors and filters, and predictive displays. This experiment examined the effects of both fixed and variable time lag on a simulated-indirect-vision-driving task, as well as a possible mitigation (predictive display) for these effects. Results revealed that variable time lag significantly increased average lane offset more than fixed time lag, which indicates a decrease in driver accuracy. A predictive display significantly reduced lane offset and increased vehicle speed for both fixed and variable time lags. The predictive display also resulted in lower reports of operator workload. These results revealed the negative performance affects of variable time lag and demonstrated the utility of a predictive display to overcome the negative performance effects associated with fixed and variable time lags. C1 [Davis, James; Smyth, Christopher; McDowell, Kaleb] USA, Res Lab, Aberdeen, MD 21005 USA. RP Davis, J (reprint author), USA, Res Lab, Aberdeen, MD 21005 USA. EM james.davisjr6@us.army.mil; christopher.smyth@us.army.mil; kaleb.mcdowell@us.army.mil RI McDowell, Kaleb/A-3410-2009 FU U.S. Army Research Laboratory FX Manuscript received April 27, 2009; revised January 22, 2010; accepted March 16, 2010. Date of publication May 6, 2010; date of current version June 9, 2010. This paper was recommended for publication by Associate Editor M. C. Cavusoglu and Editor J.-P. Laumond upon evaluation of the reviewers' comments. This work was supported in part by the U.S. Army Research Laboratory under the Improved Mobility and Operational Performance through Autonomous Mobility Army Technology Objective program. NR 32 TC 3 Z9 3 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1552-3098 J9 IEEE T ROBOT JI IEEE Trans. Robot. PD JUN PY 2010 VL 26 IS 3 BP 590 EP 593 DI 10.1109/TRO.2010.2046695 PG 4 WC Robotics SC Robotics GA 607XW UT WOS:000278541600017 ER PT J AU Kaplan, S Cortina, J Ruark, GA AF Kaplan, Seth Cortina, Jose Ruark, Gregory A. TI Oops .... We Did It Again: Industrial-Organizational's Focus on Emotional Intelligence Instead of on Its Relationships to Work Outcomes SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND PRACTICE LA English DT Article ID JOB-PERFORMANCE; PERSONALITY; LEADERSHIP; VALIDITY; MODEL C1 [Kaplan, Seth; Cortina, Jose] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. [Ruark, Gregory A.] USA, Res Inst, Ft Leavenworth Res Unit, Montgomery, AL USA. RP Kaplan, S (reprint author), George Mason Univ, Dept Psychol, 4400 Univ Ave,MSN 3F5, Fairfax, VA 22030 USA. EM skaplan1@gmu.edu NR 26 TC 3 Z9 5 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1754-9426 J9 IND ORGAN PSYCHOL-US JI Ind. Organ. Psychol. PD JUN PY 2010 VL 3 IS 2 BP 171 EP 177 DI 10.1111/j.1754-9434.2010.01220.x PG 7 WC Psychology, Applied SC Psychology GA 754XK UT WOS:000289890900012 ER PT J AU Wereszczak, AA Kirkland, TP Ragan, ME Strong, KT Lin, HT Patel, P AF Wereszczak, Andrew A. Kirkland, Timothy P. Ragan, Meredith E. Strong, Kevin T., Jr. Lin, Hua-Tay Patel, Parimal TI Size Scaling of Tensile Failure Stress in a Float Soda-Lime-Silicate Glass SO INTERNATIONAL JOURNAL OF APPLIED GLASS SCIENCE LA English DT Article AB The (tensile) strength-size scaling of a float soda-lime-silicate glass was studied using biaxial flexure and Hertzian ring crack initiation testing. The examined Weibull effective areas spanned similar to 0.4-48,000 mm(2). Both the air and tin sides were tested. The air side was stronger than the tin side as others have observed; however, the differences in their characteristic strengths decreased with a decreasing effective area, and their strengths converged for effective areas smaller than similar to 100 mm(2). The failure stress at the smallest effective area examined for the tin side was similar to 500% greater than that at the largest effective area, while that difference was similar to 250% for the air side. A Weibull modulus change at similar to 100 mm2 suggests different strength-limiting flaw types were dominant below and above this effective area. These results reinforce the importance of the interpretation and use of the tensile strength of glass in context to how much of its area is being subjected to tensile stress. C1 [Wereszczak, Andrew A.; Kirkland, Timothy P.; Ragan, Meredith E.; Strong, Kevin T., Jr.; Lin, Hua-Tay] Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. [Patel, Parimal] USA, Res Lab, Ceram & Transparent Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Wereszczak, AA (reprint author), Oak Ridge Natl Lab, Oak Ridge, TN 37831 USA. EM wereszczakaa@ornl.gov RI Wereszczak, Andrew/I-7310-2016 OI Wereszczak, Andrew/0000-0002-8344-092X FU United States Government [DE-AC05-00OR22725]; United States Department of Energy FX This study was supported by a contractor of the United States Government under contract DE-AC05-00OR22725 with the United States Department of Energy. The United States Government retains, and the publisher, by accepting this submission for publication, acknowledges that the United States Government retains, a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this submission, or allow others to do so, for United States Government purposes. NR 26 TC 10 Z9 10 U1 0 U2 3 PU WILEY PERIODICALS, INC PI SAN FRANCISCO PA ONE MONTGOMERY ST, SUITE 1200, SAN FRANCISCO, CA 94104 USA SN 2041-1286 J9 INT J APPL GLASS SCI JI Int. J. Appl. Glass Sci. PD JUN PY 2010 VL 1 IS 2 BP 143 EP 150 DI 10.1111/j.2041-1294.2010.00014.x PG 8 WC Materials Science, Ceramics SC Materials Science GA V26BI UT WOS:000208520700002 ER PT J AU Stevenson, WH McQuaid, MJ AF Stevenson, William H., III McQuaid, Michael J. TI Dissociation Constants of 2-Azidoethanamines in Aqueous Solution SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article DE aqueous dissociation constants; organic azides; density functional theory; polarizable continuum model ID POLARIZABLE CONTINUUM MODEL; DENSITY-FUNCTIONAL THEORY; COMPLETE BASIS-SET; 1ST-ROW ELEMENTS; SOLVATION; BASICITIES; ENERGIES AB Aqueous-phase dissociation constants (K(a)) for the conjugate acids of a series of 2-azidoethanamine bases: R(1)N(R(2))CH(2)CH(2)N(3) (1, R(1) = CH(3), R(2) = H; 2, R(1) = CH(3), R(2) = CH(3); 3, R(1) = CH(2)CH(3), R(2) = CH(2)CH(3); 4, R(1)/R(2) = -CH(2)CH(2)CH(2)CH(2)-; 5, R(1)/R(2) = CH(2)CH(2)OCH(2)CH(2)-; 6, R(1) = CH(2)CH(3), R(2) = CH(2)CH(2)N(3)) were measured and found to fall between those for analogous unfunctionalized and cyanofunctionalized ethanamines. To explore the possibility of a relationship existing between the constants and molecular geometry, a theoretically based study was conducted. In it, the Gibbs free energies of aqueous-phase (equilibrium) conformers of the bases and their conjugate acids were determined via a density functional theory/polarizable continuum model method. The results indicate that an attractive interaction between the amine and azide groups that underlies the lowest-energy gas-phase conformer of 2 is negated in an aqueous environment by solvent-solute interactions. The magnitudes of the free energy changes of solvation and -TS (entropic) energies of the conformers of the 2-azidoethanamines and their conjugate acids are observed to correlate with the magnitude of the separation between the conformers' amine and azide groups. However, those correlations are not by themselves sufficient to predict the relative free energies of a molecule's conformers in an aqueous environment. That insufficiency is due to the influence of the correlations being mitigated by three other parameters that arise within the thermodynamic framework employed to compute the observable. The nature of those parameters is discussed. (C) 2009 Wiley Periodicals, Inc. Int J Quantum Chem 110: 1376-1393, 2010* C1 [McQuaid, Michael J.] USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. [Stevenson, William H., III] ERC Inc, Huntsville, AL 35815 USA. RP McQuaid, MJ (reprint author), USA, Res Lab, AMSRD, ARL,WM,BD, Aberdeen Proving Ground, MD 21005 USA. EM mcquaid@arl.army.mil FU US Army Environmental Quality Technology Program FX Contract grant sponsor: US Army Environmental Quality Technology Program. NR 28 TC 1 Z9 1 U1 2 U2 3 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0020-7608 J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PD JUN PY 2010 VL 110 IS 7 BP 1376 EP 1393 DI 10.1002/qua.22231 PG 18 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA 583LD UT WOS:000276675900010 ER PT J AU Aungst, MJ Bearss, JJ Lewis, BS Fischer, JR Bonhage, MR Wright, J AF Aungst, Matthew J. Bearss, Jeremy J. Lewis, Bridget S. Fischer, John R. Bonhage, Michael R. Wright, Johnnie, Jr. TI Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article; Proceedings Paper CT Annual Meeting of the Armed Forces District of the American-College-of-Obstetricians-and-Gynecologists CY NOV 15-18, 2009 CL Honolulu, HI SP Amer Coll Obstetricians & Gynecologists, Armed Forces Dist DE Bioprosthesis; Fistula; Models, animal; New Zealand white rabbit; Rectovaginal fistula; Xenograft ID SMALL-INTESTINAL SUBMUCOSA; ENDORECTAL ADVANCEMENT FLAP; PROSTHETIC MATERIAL; SURGISIS(TM) MESH; VAGINA MODEL; DERMAL GRAFT; FASCIA LATA AB The objective was to use an animal model to study different types of interposition grafts for rectovaginal fistula repair. Twelve New Zealand white rabbits underwent surgical creation of a rectovaginal fistula, followed by repair. Four repair techniques were studied; three with interposition grafts and one control group without a graft. Animals were euthanized at 4-week intervals and underwent gross and histologic analysis. The mean rectovaginal wall thickness was greatest in the control group (5.6 mm) and thinnest in the autologous rectus fascia (4.2 mm) and porcine small intestine submucosa (5.1 mm) groups. The polypropylene graft had a mean thickness of 5.4 mm and elicited a strong, protracted inflammatory response. All fistulas were successfully closed except one porcine small intestine submucosa repair. There is no benefit from interposition graft use for rectovaginal fistula repair in our New Zealand white rabbit model. C1 [Aungst, Matthew J.; Fischer, John R.; Wright, Johnnie, Jr.] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Washington, DC 20307 USA. [Bearss, Jeremy J.; Lewis, Bridget S.; Bonhage, Michael R.] Armed Forces Inst Pathol, Dept Vet Pathol, Washington, DC 20306 USA. RP Aungst, MJ (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Bldg 2,Rm 2J06,6900 Georgia Ave, Washington, DC 20307 USA. EM Matt.Aungst@yahoo.com NR 22 TC 2 Z9 2 U1 0 U2 1 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0937-3462 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD JUN PY 2010 VL 21 IS 6 BP 737 EP 742 DI 10.1007/s00192-010-1096-2 PG 6 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA 587CF UT WOS:000276964000018 PM 20143048 ER PT J AU Kiwanuka, N Robb, M Laeyendecker, O Kigozi, G Wabwire-Mangen, F Makumbi, FE Nalugoda, F Kagaayi, J Eller, M Eller, LA Serwadda, D Sewankambo, NK Reynolds, SJ Quinn, TC Gray, RH Wawer, MJ Whalen, CC AF Kiwanuka, Noah Robb, Merlin Laeyendecker, Oliver Kigozi, Godfrey Wabwire-Mangen, Fred Makumbi, Fredrick E. Nalugoda, Fred Kagaayi, Joseph Eller, Michael Eller, Leigh Anne Serwadda, David Sewankambo, Nelson K. Reynolds, Steven J. Quinn, Thomas C. Gray, Ronald H. Wawer, Maria J. Whalen, Christopher C. TI HIV-1 Viral Subtype Differences in the Rate of CD4(+) T-Cell Decline Among HIV Seroincident Antiretroviral Naive Persons in Rakai District, Uganda SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE HIV-1 subtypes; rate of CD4(+); cell decline; HIV disease progression ID DISEASE PROGRESSION; TYPE-1 SUBTYPES; INFECTION; COHORT; TANZANIA; LOAD; ASSOCIATION; LYMPHOCYTES; POPULATION; SYPHILIS AB Background: Data on the effect of HIV-1 viral subtype on CD4(+) T-cell decline are limited. Methods: We assessed the rate of CD4(+) T-cell decline per year among 312 HIV seroincident persons infected with different HIV-1 subtypes. Rates of CD4(+) decline by HIV-1 subtype were determined by linear mixed effects models, using an unstructured convariance structure. Results: A total of 59.6% had D, 15.7% A, 18.9% recombinant viruses (R), and 5.8% multiple subtypes (M). For all subtypes combined, the overall rate of CD4(+) T-cell decline was -34.5 [95% confidence interval (CI), -47.1, -22.0] cells/mu L per yr, adjusted for age, sex, baseline CD4(+) counts, and viral load. Compared with subtype A, the adjusted rate of CD4 cell loss was -73.7/mu L/yr (95% CI, -113.5, -33.8, P < 0.001) for subtype D, -43.2/mu L/yr ( 95% CI, -90.2, 3.8, P = 0.072) for recombinants, and -63.9/mu L/yr ( 95% CI, -132.3, 4.4, P = 0.067) for infection with multiple HIV subtypes. Square-root transformation of CD4(+) cell counts did not change the results. Conclusions: Infection with subtype D is associated with significantly faster rates of CD4(+) T-cell loss than subtype A. This may explain the more rapid disease progression for subtype D compared with subtype A. C1 [Kiwanuka, Noah; Wabwire-Mangen, Fred; Makumbi, Fredrick E.; Whalen, Christopher C.] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Kampala, Uganda. [Kiwanuka, Noah; Kigozi, Godfrey; Makumbi, Fredrick E.; Nalugoda, Fred; Kagaayi, Joseph] Uganda Virus Res Inst, Rakai Hlth Sci Program, Dept Res Studies, Entebbe, Uganda. [Robb, Merlin; Laeyendecker, Oliver; Reynolds, Steven J.; Quinn, Thomas C.] Henry M Jackson Fdn, Dept HIV Res, Rockville, MD USA. [Laeyendecker, Oliver; Quinn, Thomas C.] NIAID, NIH, Bethesda, MD 20892 USA. [Eller, Michael; Eller, Leigh Anne] Johns Hopkins Sch Med, Baltimore, MD USA. [Serwadda, David] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sewankambo, Nelson K.; Wawer, Maria J.] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Dis Control & Environm Hlth, Kampala, Uganda. [Gray, Ronald H.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. [Whalen, Christopher C.] Univ Georgia, Sch Publ Hlth, Dept Epidemiol, Dept Populat & Family Hlth Sci, Atlanta, GA USA. RP Kiwanuka, N (reprint author), Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, POB 7072, Kampala, Uganda. EM nkiwanuka@rhsp.org RI Laeyendecker, Oliver/B-9331-2009; OI Sewankambo, Nelson/0000-0001-9362-053X; Laeyendecker, Oliver/0000-0002-6429-4760 FU Department of the Army; Department of the Army, United States Army Medical Research and Material Command; Henry M. Jackson Foundation; Fogarty Foundation [5D43TW00010, 2 D 43 TW000010-19]; NIH; Case Western Reserve University, USA; Division of Intramural Research, NIAID, NIH FX Supported by the Department of the Army, United States Army Medical Research and Material Command Cooperative Agreement DAMD17-98-2-8007 and the Henry M. Jackson Foundation, grants 5D43TW00010 and 2 D 43 TW000010-19 from the Fogarty Foundation, NIH, and Fogarty AIDS International Training and Research Program at Case Western Reserve University, USA, and supported by the Division of Intramural Research, NIAID, NIH. The content does not necessarily reflect the position or policies of the US Government, the Department of Army, MRCM, the Henry M. Jackson Foundation, or the Fogarty Foundation, NIH. NR 28 TC 51 Z9 52 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD JUN PY 2010 VL 54 IS 2 BP 180 EP 184 DI 10.1097/QAI.0b013e3181c98fc0 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 601XK UT WOS:000278100600010 PM 20010433 ER PT J AU Waibel, KH Gomez, R AF Waibel, Kirk H. Gomez, Robert TI Ovalbumin content of influenza vaccines Reply SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Letter C1 [Waibel, Kirk H.] Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA. [Gomez, Robert] Wilford Hall USAF Med Ctr, Dept Med, Allergy Immunol Clin, San Antonio, TX 78236 USA. RP Waibel, KH (reprint author), Brooke Army Med Ctr, Dept Med, Allergy Immunol Serv, Ft Sam Houston, TX 78234 USA. EM kirk.waibel@amedd.army.mil NR 3 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JUN PY 2010 VL 125 IS 6 BP 1413 EP 1414 DI 10.1016/j.jaci.2010.03.011 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 611PH UT WOS:000278831000043 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Lincoln's Political Generals SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Rafuse, Ethan S.] USA Command, Ft Leavenworth, KS USA. [Rafuse, Ethan S.] Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA Command, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD JUN PY 2010 VL 97 IS 1 BP 185 EP 186 PG 2 WC History SC History GA 612SX UT WOS:000278924500054 ER PT J AU Hubal, MJ Devaney, JM Hoffman, EP Zambraski, EJ Gordish-Dressman, H Kearns, AK Larkin, JS Adham, K Patel, RR Clarkson, PM AF Hubal, Monica J. Devaney, Joseph M. Hoffman, Eric P. Zambraski, Edward J. Gordish-Dressman, Heather Kearns, Amy K. Larkin, Justin S. Adham, Kasra Patel, Ronak R. Clarkson, Priscilla M. TI CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE monocyte chemoattractant protein-1; rhabdomyolysis; single-nucleotide polymorphisms ID SINGLE NUCLEOTIDE POLYMORPHISMS; CREATINE-KINASE RESPONSE; ACUTE-RENAL-FAILURE; EXERTIONAL RHABDOMYOLYSIS; ECCENTRIC EXERCISE; SATELLITE CELLS; MACROPHAGES; INJURY; REGENERATION; DEHYDRATION AB Hubal MJ, Devaney JM, Hoffman EP, Zambraski EJ, Gordish-Dressman H, Kearns AK, Larkin JS, Adham K, Patel RR, Clarkson PM. CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol 108: 1651-1658, 2010. First published March 25, 2010; doi:10.1152/japplphysiol. 00361.2009.-Novel eccentric (lengthening contraction) exercise typically results in muscle damage, which manifests as prolonged muscle dysfunction, delayed onset muscle soreness, and leakage of muscle proteins into circulation. There is a large degree of variability in the damage response of individuals to eccentric exercise, with higher responders at risk for potentially fatal rhabdomyolysis. We hypothesized that single nucleotide polymorphisms (SNPs) in chemokine ligand 2 (CCL2) and its receptor chemokine receptor 2 (CCR2) associate with the high degrees of variability in the muscle damage response. We based this hypothesis on CCL2' s roles in macrophage and satellite cell signaling in injured muscle. DNA was obtained from 157 untrained men and women following maximal eccentric exercise. Strength loss, soreness, serum creatine kinase (CK), and myoglobin levels before and during recovery from a single exercise bout were tested for association with 16 SNPs in CCL2 and CCR2. The rare alleles for rs768539 and rs3918358 (CCR2) were significantly (P < 0.05) associated with lower preexercise strength in men, whereas CCL2 SNPs (rs13900, rs1024611, and rs1860189) and CCR2 (rs1799865) were associated with altered preexercise CK levels in women. During recovery, the rs3917878 genotype (CCL2) was associated with attenuated strength recovery in men and an elevated CK response in women. CCR2 variants were associated with slower strength recovery in women (rs3918358) and elevated soreness (rs1799865) across all subjects. In summary, we found that SNPs in CCL2 and CCR2 are associated with exercise-induced muscle damage and that the presence of certain variants may result in an exaggerated damage response to strenuous exercise. C1 [Hubal, Monica J.; Devaney, Joseph M.; Hoffman, Eric P.; Gordish-Dressman, Heather; Larkin, Justin S.; Adham, Kasra; Patel, Ronak R.] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA. [Zambraski, Edward J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Kearns, Amy K.; Clarkson, Priscilla M.] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA. [Larkin, Justin S.; Adham, Kasra; Patel, Ronak R.] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA. RP Hubal, MJ (reprint author), Childrens Natl Med Ctr, Med Genet Res Ctr, 111 Michigan Ave NW, Washington, DC 20010 USA. EM mhubal@cnmcresearch.org OI Hubal, Monica/0000-0001-6579-6036 FU Medinova, Incorporated FX This study was funded by Medinova, Incorporated. NR 35 TC 29 Z9 31 U1 1 U2 12 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 2010 VL 108 IS 6 BP 1651 EP 1658 DI 10.1152/japplphysiol.00361.2009 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 617KR UT WOS:000279280100030 PM 20339010 ER PT J AU Washington, C Metzgar, D Hazbon, MH Binn, L Lyons, A Coward, C Kuschner, R AF Washington, Cicely Metzgar, David Hazbon, Manzour Hernando Binn, Leonard Lyons, Arthur Coward, Carl Kuschner, Robert TI Multiplexed Luminex xMAP Assay for Detection and Identification of Five Adenovirus Serotypes Associated with Epidemics of Respiratory Disease in Adults SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID REAL-TIME PCR; US MILITARY RECRUITS; YOUNG-ADULTS; INFECTIONS; COINFECTIONS; EMERGENCE; HEALTHY; ILLNESS; PANEL AB Several serotypes of human adenovirus (HAdV) cause acute respiratory disease (ARD) among healthy adults, sometimes generating broad outbreaks with high attack rates and occasional fatalities. Timely serotype identification provides valuable epidemiological information and significantly contributes to prevention (vaccination) strategies. The prevalence of specific serotypes causing ARD varies geographically. HAdV-3, HAdV-4, HAdV-7, HAdV-14, and HAdV-21 are the serotypes most commonly found in adult populations in the Western Hemisphere. Unfortunately, conventional serotype identification is a tedious process which can take a week or longer. For this reason, new molecular methods for serotype identification are needed. Commercially available rapid antigen and PCR assays for the detection of HAdV are universal but do not distinguish between the different serotypes. We describe the development of a sensitive and specific multiplex assay capable of identifying serotypes 3, 4, 7, 14, and 21. Two sets of primers were used for nonspecific (universal) PCR amplification, and serotype-specific probes coupled to Luminex tags were used for target-specific extension (TSE). PCR and TSE primers were designed using known hexon gene sequences of HAdV. The TSE products of HAdV-3, HAdV-4, HAdV-7, HAdV-14, and HAdV-21 were correctly identified using the Luminex xMAP fluid microsphere-based array system. No cross-reactivity with other respiratory pathogens or other HAdV serotypes was observed. This multiplexed assay can be expanded to include more serotypes and will allow broad and rapid detection and identification of adenoviral serotypes in a high-throughput environment. C1 [Washington, Cicely; Hazbon, Manzour Hernando; Binn, Leonard; Lyons, Arthur; Coward, Carl; Kuschner, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. [Metzgar, David] USN, Hlth Res Ctr, Dept Resp Dis Res, San Diego, CA 92152 USA. RP Washington, C (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Cicely.Washington@us.army.mil RI Lyons, Arthur/B-8923-2011 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center under WRAIR protocol [1566] FX This work is supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center under WRAIR protocol 1566. NR 37 TC 19 Z9 21 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2010 VL 48 IS 6 BP 2217 EP 2222 DI 10.1128/JCM.00029-10 PG 6 WC Microbiology SC Microbiology GA 602DG UT WOS:000278118100034 PM 20410343 ER PT J AU Lee, J Decker, JF Polimeni, G Cortella, CA Rohrer, MD Wozney, JM Hall, J Susin, C Wikesjo, UME AF Lee, Jaebum Decker, John F. Polimeni, Giuseppe Cortella, Carlo Alberto Rohrer, Michael D. Wozney, John M. Hall, Jan Susin, Cristiano Wikesjoe, Ulf M. E. TI Evaluation of implants coated with rhBMP-2 using two different coating strategies: a critical-size supraalveolar peri-implant defect study in dogs SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE bone density; bone formation; bone remodelling; dental implant; osseointegration; rhBMP-2; tissue engineering ID BONE MORPHOGENETIC PROTEIN-2; ALVEOLAR RIDGE AUGMENTATION; TITANIUM IMPLANTS; RADIOGRAPHIC OBSERVATIONS; GRINDING TECHNIQUE; MODEL; REGENERATION; RECONSTRUCTION AB P>Background Implants coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) induce relevant bone formation but also resident bone remodelling. Objectives To compare the effect of implants fully or partially coated with rhBMP-2 on new bone formation and resident bone remodelling. Materials and Methods Twelve, male, adult, Hound Labrador mongrel dogs were used. Critical-size, supraalveolar, peri-implant defects received titanium porous oxide surface implants coated in their most coronal aspect with rhBMP-2 (coronal-load/six animals) or by immersion of the entire implant in an rhBMP-2 solution (soak-load/six animals) for a total of 30 mu g rhBMP-2/implant. All implants were air-dried. The animals were euthanized at 8 weeks for histometric evaluation. Results Clinical healing was uneventful. Supraalveolar bone formation was not significantly affected by the rhBMP-2 application protocol. New bone height and area averaged (+/- SE) 3.4 +/- 0.2 versus 3.5 +/- 0.4 mm and 2.6 +/- 0.4 versus 2.5 +/- 0.7 mm2 for coronal-load and soak-load implants, respectively (p > 0.05). The corresponding bone density and bone-implant contact (BIC) recordings averaged 38.0 +/- 3.8% versus 34.4 +/- 5.6% and 25.0 +/- 3.8% versus 31.2 +/- 3.3% (p > 0.05). In contrast, resident bone remodelling was significantly influenced by the rhBMP-2 application protocol. Bone density outside the implants threads averaged 74.7 +/- 3.8% and 50.8 +/- 4.1% for coronal-load and soak-load implants, respectively (p < 0.05); bone density within the thread area averaged 51.8 +/- 1.2% and 37.8 +/- 2.9%, and BIC 70.1 +/- 6.7% and 43.3 +/- 3.9% (p < 0.05). Conclusion Local application of rhBMP-2 appears to be a viable technology to support local bone formation and osseointegration. Coronal-load implants obviate resident bone remodelling without compromising new bone formation. C1 [Lee, Jaebum] Med Coll Georgia, Sch Dent, Dept Periodont, LAPCR, Augusta, GA 30912 USA. [Lee, Jaebum; Susin, Cristiano; Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA. [Decker, John F.] USA, Ft Gordon, GA USA. [Cortella, Carlo Alberto] Univ Milan San Rafaele, Dept Periodontol, Milan, Italy. [Rohrer, Michael D.] Univ Minnesota, Sch Dent, Div Oral & Maxillofacial Pathol, Minneapolis, MN 55455 USA. [Wozney, John M.] Wyeth Res, Tissue Repair, Cambridge, MA USA. [Hall, Jan] Nobel Biocare AB, Res & Dev, Gothenburg, Sweden. RP Lee, J (reprint author), Med Coll Georgia, Sch Dent, Dept Periodont, LAPCR, 1120 15th St,AD-1432, Augusta, GA 30912 USA. EM jaelee@mcg.edu RI Wikesjo, Ulf/A-4159-2009; Susin, Cristiano/B-9822-2008 OI Wikesjo, Ulf/0000-0003-1607-0583; FU Nobel Biocare AB, Goteborg, Sweden FX The authors thank Dr. Nancy A. Rodriguez for veterinary support; Cedrick Bouey and Jamie Frank for animal technical care and husbandry; Hari S Prasad, BS, MDT for expert histotechnical preparations; and Kimberly Curtis for administrative support. This study was supported by a grant from Nobel Biocare AB, Goteborg, Sweden. NR 24 TC 19 Z9 21 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD JUN PY 2010 VL 37 IS 6 BP 582 EP 590 DI 10.1111/j.1600-051X.2010.01557.x PG 9 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 596NG UT WOS:000277691300012 PM 20345393 ER PT J AU Klungthong, C Chinnawirotpisan, P Hussem, K Phonpakobsin, T Manasatienkij, W Ajariyakhajorn, C Rungrojcharoenkit, K Gibbons, RV Jarman, RG AF Klungthong, Chonticha Chinnawirotpisan, Piyawan Hussem, Kittinun Phonpakobsin, Thipwipha Manasatienkij, Wudtichai Ajariyakhajorn, Chuanpis Rungrojcharoenkit, Kamonthip Gibbons, Robert V. Jarman, Richard G. TI The impact of primer and probe-template mismatches on the sensitivity of pandemic influenza A/H1N1/2009 virus detection by real-time RT-PCR SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Novel influenza A (H1N1) 2009; Real-time; RT-PCR; Primer; Probe; Mismatches ID POLYMERASE CHAIN-REACTION; IMMUNODEFICIENCY-VIRUS; SEQUENCE; VACCINE; CLUSTAL; MODEL AB Background: In response to the 2009 H1N1 pandemic the US CDC and WHO rapidly developed and distributed a real-time RT-PCR kit to detect this strain in clinical samples. The results from the WHO swH1 primer and probe set exhibited diverse sensitivities for the 2009 influenza A/H1N1 strains in Southeast Asia (SEA). Objective: Investigate the primer and probe-template mismatches among the 2009 influenza A/H1N1 strains in SEA that reduced the real-time RT-PCR sensitivity. Study design: Thirty-seven swH1 positive samples categorized into sensitive and insensitive groups based on real-time RT-PCR results were selected for hemagglutinin (HA) gene sequencing. The sequence in swH1 primer and probe binding regions of the viruses was examined for mismatches. Phylogenetic analysis was performed to investigate the diversity among these viruses. Primers and probe were redesigned to match each of our sequences and tested to determine the impact on sensitivity. Results: HA sequencing of the viruses isolated from patients with high and low sensitivities revealed that a single mismatch at the 3rd base of the probe reduced sensitivity in 23/37 viruses. Homologous primers and probes increased the sensitivity (mean difference 4.66 Ct P < 0.0001). Phylogenetic tree revealed that the viruses in this study clustered into two groups, coinciding with RT-PCR sensitivity. Conclusion: Results obtained indicate that at least two variants of the novel H1N1 transmitting in SEA and the mutations in HA gene have a direct effect on the detection by using WHO swH1 primer and probe set. Published by Elsevier B.V. C1 [Klungthong, Chonticha; Chinnawirotpisan, Piyawan; Hussem, Kittinun; Phonpakobsin, Thipwipha; Manasatienkij, Wudtichai; Ajariyakhajorn, Chuanpis; Rungrojcharoenkit, Kamonthip; Gibbons, Robert V.; Jarman, Richard G.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Jarman, RG (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM richard.jarman@afrims.org RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center FX This work is supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center. NR 18 TC 19 Z9 20 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD JUN PY 2010 VL 48 IS 2 BP 91 EP 95 DI 10.1016/j.jcv.2010.03.012 PG 5 WC Virology SC Virology GA 590YL UT WOS:000277264300003 PM 20413345 ER PT J AU Velasco, JMS Montesa-Develos, ML Jarman, RG Lopez, MNB Gibbons, RV Valderama, MTG Yoon, IK AF Velasco, John Mark S. Montesa-Develos, Maribel L. Jarman, Richard G. Lopez, Ma. Nila B. Gibbons, Robert V. Valderama, Maria Theresa G. Yoon, In-Kyu TI Evaluation of QuickVue influenza A plus B rapid test for detection of pandemic influenza A/H1N1 2009 SO JOURNAL OF CLINICAL VIROLOGY LA English DT Article DE Sensitivity; Specificity; QuickVue rapid test; Polymerase chain reaction; Novel influenza H1N1 ID CLINICAL-DIAGNOSIS; CHILDREN; SENSITIVITY; PERFORMANCE; INFECTION; VIRUS; H1N1; PATTERNS AB Background: A novel influenza A/H1N1 emerged in early 2009 and by June 2009 was declared a pandemic by WHO. Rapid influenza antigen detection tests have been used to diagnose seasonal influenza but have not been adequately evaluated for the pandemic strain among all age groups. In the Philippines, pandemic influenza A/H1N1 2009 was first detected in May 2009 and by July 2009, 3207 cases and 6 deaths were reported. Objectives: Using RT-PCR as the gold standard, clinical sensitivity/specificity of Quidel QuickVue (QV) influenza A+B was estimated across all age groups for pandemic influenza A/H1N1 using nasal swabs in a hospital setting. Effect of age, viral titers (Ct values), and timing of collection on QV sensitivity to detect pandemic influenza A/H1N1 2009 was also determined. Study Design: Febrile patients with influenza-like illness (n=360) at the V. Luna General Hospital, Manila from 1 June to 31 August 2009 were included. Nasal swabs were tested using QV and RT-PCR. Results: Of 360 nasal specimens 226 (63%) were positive for pandemic influenza A/H1N1. QV sensitivity was 63% (95% confidence interval (CI): 56-69%), specificity was 96% (95% CI: 91-99%), positive predictive value was 97% (CI: 93-99%), and negative predictive value was 57% (95% CI: 49-64%). Patient's age, fever severity, presenting symptoms or number of symptoms did not significantly affect QV sensitivity, however QV sensitivity was correlated with decreasing Ct values. Conclusion: QuickVue demonstrated moderate sensitivity for pandemic influenza A/H1N1 infection. There was a significant inverse association between Ct values and QV sensitivity for pandemic influenza A/H1N1. (C) 2010 Elsevier B.V. All rights reserved. C1 [Velasco, John Mark S.; Jarman, Richard G.; Gibbons, Robert V.; Valderama, Maria Theresa G.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Montesa-Develos, Maribel L.; Lopez, Ma. Nila B.] V Luna Gen Hosp, Dept Res & Training, Quezon City, Philippines. RP Velasco, JMS (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM VelascoJM@afrims.org RI Valle, Ruben/A-7512-2013 FU Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center FX We acknowledge VLGH staff for sample collection, AFRIMS personnel, Mr. Kittinun Hussem and Ms. Thipwipha Phonpakobsin for RT-PCR testing, Office of the Surgeon General, Philippines for coordination, and Dr. Mark Angelo Ang for statistical support. This work was supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center. NR 26 TC 17 Z9 18 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1386-6532 J9 J CLIN VIROL JI J. Clin. Virol. PD JUN PY 2010 VL 48 IS 2 BP 120 EP 122 DI 10.1016/j.jcv.2010.03.010 PG 3 WC Virology SC Virology GA 590YL UT WOS:000277264300009 PM 20399140 ER PT J AU Postman-Caucheteux, WA Birn, RM Pursley, RH Butman, JA Solomon, JM Picchioni, D McArdle, J Braun, AR AF Postman-Caucheteux, Whitney Anne Birn, Rasmus M. Pursley, Randall H. Butman, John A. Solomon, Jeffrey M. Picchioni, Dante McArdle, Joe Braun, Allen R. TI Single-trial fMRI Shows Contralesional Activity Linked to Overt Naming Errors in Chronic Aphasic Patients SO JOURNAL OF COGNITIVE NEUROSCIENCE LA English DT Article ID POSITRON-EMISSION-TOMOGRAPHY; FUNCTIONAL MRI; LANGUAGE ACTIVATION; POSTSTROKE APHASIA; NONFLUENT APHASIA; TASK-DIFFICULTY; WORD PRODUCTION; FRONTAL-CORTEX; LEXICAL ACCESS; RECOVERY AB We used fMRI to investigate the roles played by perilesional and contralesional cortical regions during language production in stroke patients with chronic aphasia. We applied comprehensive psycholinguistic analyses based on well-established models of lexical access to overt picture-naming responses, which were evaluated using a single trial design that permitted distinction between correct and incorrect responses on a trial-by-trial basis. Although both correct and incorrect naming responses were associated with left-sided perilesional activation, incorrect responses were selectively associated with robust right-sided contralesional activity. Most notably, incorrect responses elicited overactivation in the right inferior frontal gyrus that was not observed in the contrasts for patients' correct responses or for responses of age-matched control subjects. Errors were produced at slightly later onsets than accurate responses and comprised predominantly semantic paraphasias and omissions. Both types of errors were induced by pictures with greater numbers of alternative names, and omissions were also induced by pictures with late acquired names. These two factors, number of alternative names per picture and age of acquisition, were positively correlated with activation in left and right inferior frontal gyri in patients as well as control subjects. These results support the hypothesis that some right frontal activation may normally be associated with increasing naming difficulty, but in patients with aphasia, right frontal overactivation may reflect ineffective effort when left hemisphere perilesional resources are insufficient. They also suggest that contralesional areas continue to play a role-dysfunctional rather than compensatory-in chronic aphasic patients who have experienced a significant degree of recovery. C1 [Postman-Caucheteux, Whitney Anne; Birn, Rasmus M.; Pursley, Randall H.; Butman, John A.; McArdle, Joe; Braun, Allen R.] NIH, Bethesda, MD 20892 USA. [Solomon, Jeffrey M.] Med Numer Inc, Germantown, MD USA. [Picchioni, Dante] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Postman-Caucheteux, WA (reprint author), Temple Univ, Dept Commun Sci & Disorders, 110 Weiss Hall,1701 N 13th St, Philadelphia, PA 19122 USA. EM whitneyanne@alum.mit.edu RI Butman, John/A-2694-2008; Butman, John/J-2780-2013 OI Butman, John/0000-0002-1547-9195 FU John Pluta and the Center for Functional Neuroimaging at the University of Pennsylvania [NS045839] FX This work was supported by the Intramural Program of the National Institute on Deafness and Other Communication Disorders. We gratefully acknowledge the invaluable comments, critiques, and suggestions from three anonymous reviewers. The first author acknowledges John Pluta and the Center for Functional Neuroimaging at the University of Pennsylvania (NS045839) for support during the revision phase of this manuscript, and is indebted to Patricia Sokolove, Alex Martin and Bob Loeffler for their guidance and encouragement. NR 52 TC 61 Z9 65 U1 1 U2 6 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD STREET, CAMBRIDGE, MA 02142 USA SN 0898-929X J9 J COGNITIVE NEUROSCI JI J. Cogn. Neurosci. PD JUN PY 2010 VL 22 IS 6 BP 1299 EP 1318 DI 10.1162/jocn.2009.21261 PG 20 WC Neurosciences; Psychology, Experimental SC Neurosciences & Neurology; Psychology GA 572XG UT WOS:000275869700019 PM 19413476 ER PT J AU Markunas, JK Almeida, LA Jacobs, RN Pellegrino, J Qadri, SB Mahadik, N Sanghera, J AF Markunas, J. K. Almeida, L. A. Jacobs, R. N. Pellegrino, J. Qadri, S. B. Mahadik, N. Sanghera, J. TI X-ray Diffraction Imaging of Improved Bulk-Grown CdZnTe(211) and Its Comparison with Epitaxially Grown CdTe Buffer Layers on Si and Ge Substrates SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 13th International Conference on Defects - Recognition, Imaging and Physics in Semiconductors (DRIP XIII) CY SEP 13-17, 2009 CL Oglebay, WV SP Minerals, Met & Mat Soc, FEI, Semilab, Quantum Focus, Off Naval Res, Air Force Off Sci Res, Army Res Off DE CdZnTe; HgCdTe; CdTe; x-ray topography; x-ray diffraction; infrared ID MOLECULAR-BEAM EPITAXY; INFRARED DETECTORS AB Large-area high-quality Hg(1-x) Cd (x) Te sensing layers for infrared imaging in the 8 mu m to 12 mu m spectral region are typically grown on bulk Cd(1-x) Zn (x) Te substrates. Alternatively, epitaxial CdTe grown on Si or Ge has been used as a buffer layer for high-quality epitaxial HgCdTe growth. In this paper, x-ray topographs and rocking-curve full-width at half-maximum (FWHM) data will be presented for recent high-quality bulk CdZnTe grown by the vertical gradient freeze (VGF) method, previous bulk CdZnTe grown by the vertical Bridgman technique, epitaxial CdTe buffer layers on Si and Ge, and a HgCdTe layer epitaxially grown on bulk VGF CdZnTe. C1 [Markunas, J. K.; Almeida, L. A.; Jacobs, R. N.; Pellegrino, J.] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Qadri, S. B.; Mahadik, N.; Sanghera, J.] USN, Res Lab, Washington, DC 20375 USA. RP Markunas, JK (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM justin.markunas@nvl.army.mil NR 10 TC 1 Z9 2 U1 1 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUN PY 2010 VL 39 IS 6 BP 738 EP 742 DI 10.1007/s11664-010-1127-2 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 596UW UT WOS:000277712000024 ER PT J AU Williams, JB Mehta, SG Vu, T Wonderlich, DA McDermott, DM AF Williams, Justin B. Mehta, Sumeru G. Vu, Tim Wonderlich, David A. McDermott, Dustin M. TI GALLSTONE ILEUS SO JOURNAL OF EMERGENCY MEDICINE LA English DT Article C1 [Williams, Justin B.; Mehta, Sumeru G.] San Antonio Uniformed Serv Hlth Educ Consortium, Emergency Med Residency Program, Brooke Army Med Ctr, Dept Emergency Med, Ft Sam Houston, TX USA. San Antonio Uniformed Serv Hlth Educ Consortium, Emergency Med Residency Program, Wilford Hall USAF Med Ctr, Lackland AFB, TX USA. RP Williams, JB (reprint author), MCHE EMR, SAUSHEC Emergency Med Residency Brooke Army Med C, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 2 TC 0 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0736-4679 J9 J EMERG MED JI J. Emerg. Med. PD JUN PY 2010 VL 38 IS 5 BP 658 EP 660 DI 10.1016/j.jemermed.2007.11.063 PG 3 WC Emergency Medicine SC Emergency Medicine GA 610NH UT WOS:000278739200021 PM 18571359 ER PT J AU Pellerin, L Beard, LP Mandell, W AF Pellerin, Louise Beard, Les P. Mandell, Wayne TI Mapping Structures that Control Contaminant Migration using Helicopter Transient Electromagnetic Data SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article AB Tooele Army Depot, Tooele County, Utah has developed a hydrogeological model to predict spatio-temporal changes in trichloroethylene contamination originating from sources on the base. Established in 1942 to store World War II supplies, ammunition, and combat vehicles, the Depot is situated in the Basin and Range Providence about 50 km west of Salt Lake City, Utah. In order to better define this hydrogeological framework, a helicopter-borne, time-domain electromagnetic system, known as SkyTEM, was used to survey a 64-km(2) area of the Depot. Areas where carbonate basement is known from prior studies to be at or near the surface were clearly delineated in the SkyTEM data as a high resistivity zone, which begins near the ground surface and continues to the deepest samples at about 200 m. In some places the basement appears to be conductive rather than resistive. In areas where unconsolidated sedimentary cover is known to be thick, such as in the northwest part of the survey area, resistivities were low throughout the sample intervals. The SkyTEM data supports the existence of some, but not all, of the hydrological boundaries hypothesized from potentiometric information. Shallow high-resistivity layers in the east and southeast portions of the survey area appear to be underlain by more conductive sediments, and so should not necessarily be interpreted as shallow bedrock, but possibly as resistive sediments such as dry sand and gravel. One of the most significant results of the survey is the delineation of a narrow unit, interpreted as a paleochannel, at depths greater than 100 m that may be responsible for migration of contamination to the northwest. C1 [Pellerin, Louise] Green Engn Inc, Berkeley, CA 94702 USA. [Beard, Les P.] Battelle Oak Ridge Operat, Oak Ridge, TN 37830 USA. [Mandell, Wayne] USA, Environm Command, Greenville, NC 27858 USA. RP Pellerin, L (reprint author), Green Engn Inc, 2215 Curtis St, Berkeley, CA 94702 USA. EM pellerin@ak.net NR 10 TC 1 Z9 2 U1 0 U2 1 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD JUN PY 2010 VL 15 IS 2 BP 65 EP 75 PG 11 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 601VC UT WOS:000278092300002 ER PT J AU West, BJ AF West, Bruce J. TI Homeostasis and Gauss statistics: barriers to understanding natural variability SO JOURNAL OF EVALUATION IN CLINICAL PRACTICE LA English DT Article DE Gauss; homeostasis; non-linear dynamics; Pareto; statistics AB Rationale In this paper, the concept of knowledge is argued to be the top of a three-tiered system of science. Aims and objectives The first tier is that of measurement and data, followed by information consisting of the patterns within the data, and ending with theory that interprets the patterns and yields knowledge. Thus, when a scientific theory ceases to be consistent with the database the knowledge based on that theory must be re-examined and potentially modified. Results Consequently, all knowledge, like glory, is transient. Methods Herein we focus on the non-normal statistics of physiologic time series and conclude that the empirical inverse power-law statistics and long-time correlations are inconsistent with the theoretical notion of homeostasis. Conclusions We suggest replacing the notion of homeostasis with that of Fractal Physiology. C1 USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. RP West, BJ (reprint author), USA, Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA. EM bruce.j.west@us.army.mil NR 15 TC 11 Z9 11 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1356-1294 J9 J EVAL CLIN PRACT JI J. Eval. Clin. Pract. PD JUN PY 2010 VL 16 IS 3 BP 403 EP 408 DI 10.1111/j.1365-2753.2010.01459.x PG 6 WC Health Care Sciences & Services; Medical Informatics; Medicine, General & Internal SC Health Care Sciences & Services; Medical Informatics; General & Internal Medicine GA 601QM UT WOS:000278077900002 PM 20604819 ER PT J AU Cilingir, F Devaney, RL Russell, ED AF Cilingir, Figen Devaney, Robert L. Russell, Elizabeth D. TI Extending external rays throughout the Julia sets of rational maps SO JOURNAL OF FIXED POINT THEORY AND APPLICATIONS LA English DT Article DE Julia set; external rays; Mandelbrot set; symbolic dynamics AB For polynomial maps in the complex plane, the notion of external rays plays an important role in determining the structure of and the dynamics on the Julia set. In this paper we consider an extension of these rays in the case of rational maps of the form F lambda(z) = z(n) + lambda/z(n) where n > 1. As in the case of polynomials, there is an immediate basin of infinity, so we have similar external rays. We show how to extend these rays throughout the Julia set in three specific examples. Our extended rays are simple closed curves in the Riemann sphere that meet the Julia set in a Cantor set of points and also pass through countably many Fatou components. Unlike the external rays, these extended rays cross infinitely many other extended rays in a manner that helps determine the topology of the Julia set. C1 [Cilingir, Figen; Devaney, Robert L.] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA. [Russell, Elizabeth D.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Devaney, RL (reprint author), Boston Univ, Dept Math & Stat, 111 Cummington St, Boston, MA 02215 USA. EM cilingir@bu.edu; bob@bu.edu; elizabeth.russell@usma.edu FU TUBITAK FX The first author would like to thank the Department of Mathematics at Boston University for the hospitality while this work was in progress. In addition, she would also like to thank TUBITAK for their support while this research was in progress. NR 9 TC 4 Z9 4 U1 0 U2 0 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1661-7738 J9 J FIX POINT THEORY A JI J. Fixed Point Theory Appl. PD JUN PY 2010 VL 7 IS 1 BP 223 EP 240 DI 10.1007/s11784-010-0003-2 PG 18 WC Mathematics, Applied; Mathematics SC Mathematics GA 604NR UT WOS:000278286200010 ER PT J AU Barrett, A Sajjad, U Kaletunc, G AF Barrett, Ann Sajjad, Umraz Kaletunc, Gonul TI EFFECT OF BREAD CRUMB STRUCTURE AND COMPOSITION ON RATE OF MOISTURE SORPTION IN SANDWICH COMPOSITES SO JOURNAL OF FOOD PROCESSING AND PRESERVATION LA English DT Article ID FOOD SYSTEMS; STARCH; MIGRATION; MECHANISM; POROSITY; NMR AB Shelf-stable sandwiches will undergo thermodynamically driven migration of moisture from relatively high to relatively low a(w) regions, thereby potentially compromising stability and acceptance. While differences in a(w) determine the final moisture-content distribution, rates of migration can be affected by physicochemical properties of the moisture-receiving phase. Lowered a(w) bread crumb that varied in: bulk density/cell size, oil content, resistant starch content and gluten content was produced and interfaced with higher a(w) cheese and stored for 4 weeks. The bread was sliced into 5 mm sections parallel to the interface and added moisture per grain calculated for each section weekly, and distributions of g added moisture/g dry weight versus distance were determined. Treatment varied distribution parameters, and sorption was reduced in higher density, oil content and resistant starch content bread crumb. Adjustment of bread physicochemical properties can improve the shelf life of stored sandwiches. C1 [Barrett, Ann; Sajjad, Umraz] USA, Natick Soldier RD&E Ctr, Performance Enhancement & Food Safety Team, Combat Feeding Directorate, Natick, MA 01760 USA. [Kaletunc, Gonul] Ohio State Univ, Dept Food Agr & Biol Engn, Columbus, OH 43210 USA. RP Barrett, A (reprint author), USA, Natick Soldier RD&E Ctr, Performance Enhancement & Food Safety Team, Combat Feeding Directorate, Natick, MA 01760 USA. EM ann.barrett@natick.army.mil RI Kaletunc, Gonul/B-8806-2012 NR 16 TC 0 Z9 0 U1 0 U2 6 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0145-8892 EI 1745-4549 J9 J FOOD PROCESS PRES JI J. Food Process Preserv. PD JUN PY 2010 VL 34 IS 3 BP 460 EP 475 DI 10.1111/j.1745-4549.2008.00351.x PG 16 WC Food Science & Technology SC Food Science & Technology GA 607OD UT WOS:000278512600008 ER PT J AU Sessums, L Jackson, J Zembrzuska, H AF Sessums, Laura Jackson, Jeffrey Zembrzuska, Hanna TI ASSESSING MEDICAL DECISION MAKING CAPACITY, A META-ANALYSIS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 33rd Annual Meeting of the Society-of-General-Internal-Medicine CY APR 18-MAY 01, 2010 CL Minneapolis, MN SP Soc Gen Internal Med C1 [Sessums, Laura; Zembrzuska, Hanna] WRAMC, Washington, DC USA. [Jackson, Jeffrey] Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2010 VL 25 SU 3 BP 226 EP 226 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 591EO UT WOS:000277282300048 ER PT J AU Mallory, R O'Malley, P Jackson, J AF Mallory, Renee O'Malley, Patrick Jackson, Jeffrey TI CHARACTERISTICS OF TOP RATED ATTENDINGS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 33rd Annual Meeting of the Society-of-General-Internal-Medicine CY APR 18-MAY 01, 2010 CL Minneapolis, MN SP Soc Gen Internal Med C1 [Mallory, Renee] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [O'Malley, Patrick] Uniformed Serv Univ Hlth Sci, Rockville, MD USA. [Jackson, Jeffrey] Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2010 VL 25 SU 3 BP 237 EP 237 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 591EO UT WOS:000277282300074 ER PT J AU Mallory, R Jackson, J AF Mallory, Renee Jackson, Jeffrey TI FACTOR ANALYSIS OF HIGHLY RATED ATTENDINGS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 33rd Annual Meeting of the Society-of-General-Internal-Medicine CY APR 18-MAY 01, 2010 CL Minneapolis, MN SP Soc Gen Internal Med C1 [Mallory, Renee] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Jackson, Jeffrey] Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2010 VL 25 SU 3 BP 275 EP 275 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 591EO UT WOS:000277282300158 ER PT J AU Ritter, J Jackson, J AF Ritter, Joan Jackson, Jeffrey TI OUTCOME AND IMPACT OF MENTAL DISORDERS IN PRIMARY CARE AT 1-YEAR SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 33rd Annual Meeting of the Society-of-General-Internal-Medicine CY APR 18-MAY 01, 2010 CL Minneapolis, MN SP Soc Gen Internal Med C1 [Ritter, Joan] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Jackson, Jeffrey] Walter Reed Army Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2010 VL 25 SU 3 BP 340 EP 340 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 591EO UT WOS:000277282300292 ER PT J AU Jackson, J Shimeall, W O'Malley, P DeZee, K Becher, D Sessums, L AF Jackson, Jeffrey Shimeall, William O'Malley, Patrick DeZee, Kent Becher, Dorothy Sessums, Laura TI TRICYCLIC ANTIDEPRESSANTS FOR HEADACHES, AMETA-ANALYSIS SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Meeting Abstract CT 33rd Annual Meeting of the Society-of-General-Internal-Medicine CY APR 18-MAY 01, 2010 CL Minneapolis, MN SP Soc Gen Internal Med C1 [Jackson, Jeffrey] Walter Reed Army Med Ctr, Bethesda, MD USA. [Shimeall, William] Natl Naval Med Ctr, Bethesda, MD USA. [O'Malley, Patrick; DeZee, Kent] USUHS, Bethesda, MD USA. [Becher, Dorothy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Sessums, Laura] WRAMC, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2010 VL 25 SU 3 BP 418 EP 418 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 591EO UT WOS:000277282300467 ER PT J AU Jackson, JL AF Jackson, Jeffrey L. TI From the Editors' Desk: The Patient-centered Medical Home and Our Future Health-care System SO JOURNAL OF GENERAL INTERNAL MEDICINE LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Washington, DC 20305 USA. RP Jackson, JL (reprint author), Walter Reed Army Med Ctr, Washington, DC 20305 USA. EM jejackson@usuhs.mil NR 0 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0884-8734 J9 J GEN INTERN MED JI J. Gen. Intern. Med. PD JUN PY 2010 VL 25 IS 6 BP 483 EP 483 DI 10.1007/s11606-010-1305-1 PG 1 WC Health Care Sciences & Services; Medicine, General & Internal SC Health Care Sciences & Services; General & Internal Medicine GA 596UY UT WOS:000277712200001 ER PT J AU Selvarasu, NKC Tafti, DK Blackwell, NE AF Selvarasu, N. K. C. Tafti, Danesh K. Blackwell, Neal E. TI Effect of Pin Density on Heat-Mass Transfer and Fluid Flow at Low Reynolds Numbers in Minichannels SO JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME LA English DT Article DE boundary layer turbulence; entropy; external flows; heat transfer; laminar flow; microchannel flow ID CAST-ALUMINUM COLDWALLS; RIBBED DUCT; FIN ARRAYS; PERFORMANCE; EXCHANGERS AB Previous investigations on the performance of straight pins, pins with tip clearance, and profiled fins showed that closely packed cylindrical pin fins are very competitive with the modified pins. Therefore, the objective of this paper is to investigate the effect of pin density on performance. Steady/time-dependent calculations are performed to investigate the effect of pin density on friction and heat transfer. Pins packed at distances of S(D)=1.1, 1.2, 1.3, 1.4, 1.5, 2.0, 2.5, and 3 pin diameters (D) are investigated for 10 < Re(D)< 600. Two performance measures are used to compare the different pin fin densities. The first measure is to maximize heat transfer capacity for a given pumping power compared with a plane channel. The second measure used is based on entropy generation minimization (EGM), where the objective is to reduce the total irreversibility of the pin fin array to obtain an optimal spacing. Based on the performance measure of maximizing heat capacity, it is shown that for plain channels operating in the laminar range using denser pin packing has distinct advantages with S(D)=1.1 providing the best augmentation. However, the augmentation in heat capacity becomes relatively independent of the pin density for a channel operating in the turbulent regime. Based on the EGM method, at Re(D)>200, S(D)=1.3, 1.4, and 1.5 are the most suitable, with the least entropy generation observed at S(D)=1.4. At Re(D)< 200, S(D)=1.1, 1.2, and 1.3 are also suitable for keeping entropy generation low. C1 [Selvarasu, N. K. C.; Tafti, Danesh K.] Virginia Polytech Inst & State Univ, Dept Mech Engn, Blacksburg, VA 24061 USA. [Blackwell, Neal E.] USA, RDECOM, CERDEC, Ft Belvoir, VA 22060 USA. RP Tafti, DK (reprint author), Virginia Polytech Inst & State Univ, Dept Mech Engn, 114-I Randolph Hall,Mail Code 0238, Blacksburg, VA 24061 USA. EM dtafti@vt.edu RI Tafti, Danesh/A-7486-2009 NR 29 TC 5 Z9 5 U1 1 U2 8 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0022-1481 J9 J HEAT TRANS-T ASME JI J. Heat Transf.-Trans. ASME PD JUN PY 2010 VL 132 IS 6 AR 061702 DI 10.1115/1.4000949 PG 8 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA 578DO UT WOS:000276273900008 ER PT J AU Kapoor, A Simmonds, P Slikas, E Li, LL Bodhidatta, L Sethabutr, O Triki, H Bahri, O Oderinde, BS Baba, MM Bukbuk, DN Besser, J Bartkus, J Delwart, E AF Kapoor, Amit Simmonds, Peter Slikas, Elizabeth Li, Linlin Bodhidatta, Ladaporn Sethabutr, Orntipa Triki, Henda Bahri, Olfa Oderinde, Bamidele S. Baba, Marycelin M. Bukbuk, David N. Besser, John Bartkus, Joanne Delwart, Eric TI Human Bocaviruses Are Highly Diverse, Dispersed, Recombination Prone, and Prevalent in Enteric Infections SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID RESPIRATORY-TRACT INFECTIONS; ACUTE GASTROENTERITIS; BOVINE PARVOVIRUS; EPIDEMIOLOGIC PROFILE; PHYLOGENETIC ANALYSIS; ANALYSIS REVEALS; VIRUS EVOLUTION; CHILDREN; CANINE; EMERGENCE AB A new species of parvovirus, tentatively named human bocavirus 4 (HBoV4), was genetically characterized. Among 641 feces samples obtained from children and adults, the most commonly detected bocavirus species were, in descending order, HBoV2, HBoV3, HBoV4, and HBoV1, with an HBoV2 prevalence of 21% and 26% in Nigerian and Tunisian children, respectively. HBoV3 or HBoV4 species were found in 12 of 192 patients with non-polio acute flaccid paralysis in Tunisia and Nigeria and 0 of 96 healthy Tunisian contacts (P = .01). Evidence of extensive recombination at the NP1 and VP1 gene boundary between and within bocavirus species was found. The high degree of genetic diversity seen among the human bocaviruses found in feces specimens, relative to the highly homogeneous HBoV1, suggest that this worldwide-distributed respiratory pathogen may have recently evolved from an enteric bocavirus after acquiring an expanded tropism favoring the respiratory tract. Elucidating the possible role of the newly identified enteric bocaviruses in human diseases, including acute flaccid paralysis and diarrhea, will require further epidemiological studies. C1 [Kapoor, Amit; Slikas, Elizabeth; Li, Linlin; Delwart, Eric] Blood Syst Res Inst, San Francisco, CA 94118 USA. [Kapoor, Amit; Slikas, Elizabeth; Li, Linlin; Delwart, Eric] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA. [Simmonds, Peter] Univ Edinburgh, Ctr Infect Dis, Edinburgh, Midlothian, Scotland. [Bodhidatta, Ladaporn; Sethabutr, Orntipa] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Triki, Henda; Bahri, Olfa] Inst Pasteur, WHO Reg Reference Lab Poliomyelitis, Lab Clin Virol, Tunis, Tunisia. [Oderinde, Bamidele S.; Baba, Marycelin M.] Univ Maiduguri, Teaching Hosp, WHO Natl Polio Lab, Maiduguri, Borno State, Nigeria. [Bukbuk, David N.; Besser, John; Bartkus, Joanne] Minnesota Dept Hlth, Publ Hlth Lab Div, Mol Epidemiol Unit, St Paul, MN USA. RP Delwart, E (reprint author), Blood Syst Res Inst, 270 Masonic Ave, San Francisco, CA 94118 USA. EM delwarte@medicine.ucsf.edu RI Li, Linlin/E-3335-2010; Valle, Ruben/A-7512-2013; OI Bukbuk, David Nadeba/0000-0003-3388-3842; Delwart, Eric/0000-0002-6296-4484 FU Blood Systems Research Institute; National Heart, Lung and Blood Institut [R01HL083254] FX Financial support: Blood Systems Research Institute and the National Heart, Lung and Blood Institute (grant R01HL083254 to E.L.D.). NR 49 TC 165 Z9 192 U1 0 U2 9 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN 1 PY 2010 VL 201 IS 11 BP 1633 EP 1643 DI 10.1086/652416 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 589TH UT WOS:000277176200006 PM 20415538 ER PT J AU Lukish, JR AF Lukish, Jeffrey R. TI Regarding: Laparoscopic-Assisted Femoral Hernia Repair in Children SO JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES LA English DT Letter C1 [Lukish, Jeffrey R.] Natl Naval Med Ctr, Bethesda, MD USA. [Lukish, Jeffrey R.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lukish, JR (reprint author), Natl Naval Med Ctr, Bethesda, MD USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1092-6429 J9 J LAPAROENDOSC ADV S JI J. Laparoendosc. Adv. Surg. Tech. PD JUN PY 2010 VL 20 IS 5 BP 509 EP 509 DI 10.1089/lap.2009.0439 PG 1 WC Surgery SC Surgery GA 614CU UT WOS:000279033600023 PM 20565306 ER PT J AU Mrozek, RA Cole, PJ Cole, SM Schroeder, JL Schneider, DA Hedden, RC Lenhart, JL AF Mrozek, Randy A. Cole, Phillip J. Cole, Shannon M. Schroeder, John L. Schneider, Duane A. Hedden, Ronald C. Lenhart, Joseph L. TI Design of nonaqueous polymer gels with broad temperature performance: Impact of solvent quality and processing conditions SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID PRESSURE-SENSITIVE-ADHESIVES; VOLUME PHASE-TRANSITION; MOLECULAR-WEIGHT; MONTE-CARLO; HYDROGELS; TACK; NETWORKS; FILMS; ELECTROLYTES; RHEOLOGY AB Polymer gels have potential use for a wide variety of applications, primarily due to the ability to tailor the gel properties by varying several material parameters. While substantial attention has focused on water-based hydrogels, the use of these materials is limited due to a narrow operational temperature range. This report describes a nonaqueous polymer gel, composed of a cross-linked polybutadiene network swollen with low volatility polymer plasticizers. Thermal, mechanical, and adhesive characterization illustrated that the gels exhibit performance over an extremely broad temperature range (-60-70 degrees C). Solvent quality and loading played a critical role in the operational temperature window with small solvent solubility parameter deviations dramatically reducing the operational temperature range. In addition, the processing conditions had a large impact on the gel mechanical properties. As a result, it is important to consider the influence of processing conditions and solvent quality when tailoring polymer gels for practical applications. C1 [Mrozek, Randy A.; Cole, Phillip J.; Cole, Shannon M.; Schroeder, John L.; Schneider, Duane A.; Lenhart, Joseph L.] Sandia Natl Labs, Albuquerque, NM 87185 USA. [Mrozek, Randy A.; Lenhart, Joseph L.] USA, Res Lab, Aberdeen, MD 21005 USA. [Cole, Phillip J.] Northrop Grumman A&AS, Arlington, VA 22209 USA. [Hedden, Ronald C.] Texas Tech Univ, Dept Chem Engn, Lubbock, TX 79409 USA. RP Cole, PJ (reprint author), Sandia Natl Labs, POB 5800, Albuquerque, NM 87185 USA. EM Phillip.Cole_Contractor@dtra.mil; joseph.lenhartl@arl.army.mil RI Hedden, Ronald/M-3909-2014 OI Hedden, Ronald/0000-0003-3571-1403 FU ARL, Oak Ridge Institute of Science and Engineering (ORISE); United States Department of Energy's National Nuclear Security Administration [DE-AC04-94AL85000] FX This work was initiated at Sandia National Laboratories by J.L. Lenhart, P.J. Cole, and R. Mrozek and is being continued at the United States Army Research Laboratory by J.L Lenhart and R. Mrozek. R. Mrozek was funded at ARL through a contract with the Oak Ridge Institute of Science and Engineering (ORISE). Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000. Certain commercial equipment and materials are identified in this paper in order to specify adequately the experimental procedure. In no case does such identification imply recommendations by the Army Research Laboratory or does it imply that the material or equipment identified is necessarily the best available for this purpose. We thank Ms. Burcu Unal for assistance with collecting ultra-small-angle neutron scattering (USANS) data. NR 65 TC 9 Z9 9 U1 1 U2 9 PU MATERIALS RESEARCH SOC PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD JUN PY 2010 VL 25 IS 6 BP 1105 EP 1117 DI 10.1557/JMR.2010.0155 PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 602TO UT WOS:000278161900016 ER PT J AU Grujicic, M He, T Marvi, H Cheeseman, BA Yen, CF AF Grujicic, M. He, T. Marvi, H. Cheeseman, B. A. Yen, C. F. TI A comparative investigation of the use of laminate-level meso-scale and fracture-mechanics-enriched meso-scale composite-material models in ballistic-resistance analyses SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID MESOMODEL AB A critical assessment is provided of the typical laminate-level, classical meso-scale, and fracture-mechanics-enriched meso-scale material models for continuous-fiber reinforced polymer-matrix composites. Suitability of these material models for the use in structural-mechanics and ballistic-resistance computational analyses of the composite laminates is investigated by carrying out a series of computational studies in which a composite laminate is either subjected to in-plane tension/compression or bending or used as a target plate and impacted by a solid right circular cylindrical projectile. The results obtained suggest that the fracture-mechanics enriched meso-scale composite-laminate material model, in which the fracture-mechanics character of micro-cracking is included within a damage-mechanics formulation, is currently the best compromise between computational efficiency and physical-reality/fidelity. C1 [Grujicic, M.; He, T.; Marvi, H.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.; Yen, C. F.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042]; ARC/TRADE FX The material presented in this article is based on work supported by the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042 and by an ARC/TRADE research contract. NR 19 TC 9 Z9 9 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUN PY 2010 VL 45 IS 12 BP 3136 EP 3150 DI 10.1007/s10853-010-4290-1 PG 15 WC Materials Science, Multidisciplinary SC Materials Science GA 582PD UT WOS:000276609000002 ER PT J AU Yingst, SL Huzella, LM Chuvala, L Wolcott, M AF Yingst, Samuel L. Huzella, Louis M. Chuvala, Lara Wolcott, Mark TI A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID AGENTS; SYSTEM AB The US Centers for Disease Control and Prevention lists Brucella as a potential bioterrorism threat requiring enhanced diagnostic capacity and surveillance (http //emergency cdc gov/ bioterrorism/). Successful treatment and management of patients after exposure to biological threat agents depends on accurate and timely diagnosis, but many biothreat agents present with similar, vague clinical signs commonly referred to as 'flu-like illness' Diagnosis of brucellosis is notoriously challenging, especially early in infection, and definitive diagnosis may require invasive methods, e g. bone marrow biopsy. We studied the pathogenesis of Brucella suis aerosol infection in rhesus macaques in an effort to guide the diagnostic algorithm in case of possible intentional exposure of humans Rhesus proved to be an excellent model for human brucellosis, the data showed that PCR DNA amplification testing of non-invasive diagnostic samples has the potential to definitively detect a point-source outbreak immediately and for several days after exposure C1 [Yingst, Samuel L.; Huzella, Louis M.; Chuvala, Lara; Wolcott, Mark] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Chuvala, Lara] Akimeka Technol LLC, Ft Detrick, MD 21702 USA. RP Yingst, SL (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. FU DOD [02-4-KK-032 8 10030_07_RD_B] FX The opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army Work at USAMRIID was funded by DOD grant (Project # 02-4-KK-032 8 10030_07_RD_B) Research was conducted in compliance with the Animal Welfare At and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996 The facility where this research was conducted is fully accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International We thank Dave Dyer for extensive support for aerosol exposure and telemetry and Diana Fisher for statistical support. NR 17 TC 9 Z9 9 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD JUN PY 2010 VL 59 IS 6 BP 724 EP 730 DI 10.1099/jmm.0.017285-0 PG 7 WC Microbiology SC Microbiology GA 610AU UT WOS:000278702000016 PM 20223898 ER PT J AU Gumz, JE AF Gumz, Jonathan E. TI The Brusilov Offensive SO JOURNAL OF MODERN HISTORY LA English DT Book Review C1 [Gumz, Jonathan E.] US Mil Acad, West Point, NY USA. RP Gumz, JE (reprint author), US Mil Acad, West Point, NY USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-2801 J9 J MOD HIST JI J. Mod. Hist. PD JUN PY 2010 VL 82 IS 2 BP 514 EP 515 PG 3 WC History SC History GA 605UV UT WOS:000278373400048 ER PT J AU Covington, CF King, JA Fennell, I Jones, C Hutchinson, C Evans, A AF Covington, Carolyn Frances King, Joyce A. Fennell, Irnise Jones, Chanel Hutchinson, Charmaine Evans, Annette TI Developing a Community-Based Stroke Prevention Intervention Course in Minority Communities: The DC Angels Project SO JOURNAL OF NEUROSCIENCE NURSING LA English DT Article ID AMERICAN-HEART-ASSOCIATION; RISK-FACTORS; SCIENTIFIC STATEMENT; HEALTH WORKERS; WARNING SIGNS; KNOWLEDGE; DISPARITIES; DISEASE AB Despite advances in stroke treatment in the United States, stroke remains the third leading cause of death among Americans and the leading cause of serious, long-term disability in the United States. About 780,000 Americans will have a new or recurrent stroke this year. Each year, about 60,000 more women than men have a stroke. African Americans have almost twice the risk of first-ever strokes compared with Whites. Minority populations are less likely to know all stroke symptoms and far less likely to know all heart attack symptoms. There are many benefits of early treatment of stroke, yet most minorities do not get this treatment because they do not recognize the warning signs, risk factors, and prevention of stroke. The objective of this intervention course was to increase the students' knowledge and awareness of stroke, warning signs, risk factors, and prevention. Developing community-based stroke prevention intervention courses in minority communities is a good strategy to reduce morbidity and mortality and help to eliminate health disparities in minority communities. C1 [Covington, Carolyn Frances; Hutchinson, Charmaine; Evans, Annette] Howard Univ, Div Nursing, Washington, DC 20059 USA. [King, Joyce A.] Rowan Cabarrus Community Coll, Concord, NC USA. [Fennell, Irnise] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA. [Jones, Chanel] Dwight D Eisenhower Army Med Ctr, Med Surg Oncol Dept, Ft Gordon, GA USA. EM c_covington@howard.edu NR 22 TC 3 Z9 3 U1 0 U2 0 PU AMER ASSOC NEUROSCIENCE NURSES PI GLENVIEW PA 4700 W LAKE AVENUE, GLENVIEW, IL 60025 USA SN 0888-0395 J9 J NEUROSCI NURS JI J. Neurosci. Nurs. PD JUN PY 2010 VL 42 IS 3 BP 139 EP 142 PG 4 WC Clinical Neurology; Nursing SC Neurosciences & Neurology; Nursing GA 602OV UT WOS:000278149600004 PM 20550073 ER PT J AU Blair, JA Stinner, DJ Kirby, JM Gerlinger, TL Hsu, JR AF Blair, James A. Stinner, Daniel J. Kirby, Jess M. Gerlinger, Tad L. Hsu, Joseph R. CA Skeletal Trauma Res Consortium TI Quantification of Femoral Neck Exposure Through a Minimally Invasive Smith-Petersen Approach SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE Smith-Petersen; surgical exposure; anterior hip approach; femoral neck fracture ID TOTAL HIP-ARTHROPLASTY; ANTERIOR APPROACH; ANTEROLATERAL APPROACH; OPEN REDUCTION; FRACTURES; REPLACEMENT; FIXATION; FEMUR; LESS; HEAD AB Objectives: To quantify the area of osseous exposure and identify six anatomic landmarks using a direct anterior approach to the hip. Methods: Ten fresh-frozen hemipelves were dissected using a minimally invasive Smith-Petersen approach. Upon completion of the exposure, a calibrated digital image was taken from the surgeon's perspective. Identification of six osseous landmarks (anterior-superior acetabulum, anterior-inferior acetabulum, greater trochanter, lesser trochanter, anterior inferior iliac spine, and vastus ridge) was attempted either by direct visualization or palpation with a tonsil clamp. These landmarks exceed the border for any intracapsular hip fracture. The digital images were then analyzed using a computer software program, ImageJ (National Institutes of Health, Bethesda, MD), to calculate the square area of proximal femur exposed. Results: The average square area of proximal femur exposed was 20.31 cm(2) (standard deviation: 3.09, range: 15.16-24.18). The area exposed correlated with the original height of the cadaver (r = 0.69, P < 0.05). With the numbers available, there was no correlation between exposure and weight (P = 0.71) or body mass index (P = 0.87). In all 10 cadaver specimens, the 6 osseous landmarks were easily identified, 5 by direct visualization and 1 by palpation (lesser trochanter, deep portion) because of incomplete visualization. Conclusions: The minimally invasive Smith-Petersen approach to the hip allows for a wide exposure of the femoral neck averaging 20.31 cm 2 and identification of six bony critical landmarks of the hip. It may be used for open reduction of subcapital, mid-cervical, and basicervical femoral neck fractures. C1 [Blair, James A.] Brooke Army Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. [Blair, James A.; Gerlinger, Tad L.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. [Stinner, Daniel J.; Hsu, Joseph R.] USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Kirby, Jess M.] USA, Trauma Training Ctr, Ryder Trauma Ctr, Miami, FL USA. RP Blair, JA (reprint author), Brooke Army Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX 78234 USA. EM james.blair@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 FU Geneva Foundation FX JRH receives institutional research support from the Geneva Foundation. None of the other authors or the Skeletal Trauma Research Consortium have any financial disclosures to make. None of the authors have received any funding from the National Institutes of Health, Wellcome Trust, or the Howard Hughes Medical Institute. NR 27 TC 13 Z9 13 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD JUN PY 2010 VL 24 IS 6 BP 355 EP 358 DI 10.1097/BOT.0b013e3181c675d0 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 605YO UT WOS:000278385700009 PM 20502217 ER PT J AU Zhang, SS Foster, D Read, J AF Zhang, Sheng S. Foster, Donald Read, Jeffrey TI A high energy density lithium/sulfur-oxygen hybrid battery SO JOURNAL OF POWER SOURCES LA English DT Article DE Lithium/sulfur battery; Lithium/air battery; Lithium/sulfur-oxygen hybrid battery; Polysulfide; Air electrode ID SULFUR BATTERY; ELECTROCHEMICAL PROPERTIES; LITHIUM/OXYGEN BATTERY; ORGANIC ELECTROLYTE; CATHODE; DISCHARGE; CELLS AB In this paper we introduce a lithium/sulfur-oxygen (Li/S-O(2)) hybrid cell that is able to operate either in an air or in an environment without air. In the cell, the cathode is a sulfur-carbon composite electrode containing appropriate amount of sulfur. In the air, the cathode first functions as an air electrode that catalyzes the reduction of oxygen into lithium peroxide (Li(2)O(2)). Upon the end of oxygen reduction, sulfur starts to discharge like a normal Li/S cell, In the absence of oxygen or air, sulfur alone serves as the active cathode material. That is, sulfur is first reduced to form a soluble polysulfide (Li(2)S(x), x >= 4) that subsequently discharges into Li(2)S through a series of disproportionations and reductions. In general, the Li/S-O(2) hybrid cell presents two distinct discharge voltage plateaus, i.e., one at similar to 2.7 V attributing to the reduction of oxygen and the other one at similar to 2.3 V attributing to the reduction of sulfur. Since the final discharge products of oxygen and sulfur are insoluble in the organic electrolyte, it is shown that the overall specific capacity of Li/S-O(2) hybrid cell is determined by the carbon composite electrode, and that the specific capacity varies with the discharge current rate and electrode composition. In this work, we show that a composite electrode composed by weight of 70% M-30 activated carbon, 22% sulfur and 8% polytetrafluoroethylene (PTFE) has a specific capacity of 857 mAh g(-1) vs. M-30 activated carbon at 0.2 mA cm(-2) in comparison with 650 mAh g(-1) of the control electrode consisting of 92% M-30 and 8% PTFE. In addition, the self-discharge of the Li/S-O(2) hybrid cell is expected to be substantially lower when compared with the Li/S cell since oxygen can easily oxidize the soluble polysulfide into insoluble sulfur. Published by Elsevier B.V. C1 [Zhang, Sheng S.; Foster, Donald; Read, Jeffrey] USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. RP Zhang, SS (reprint author), USA, Res Lab, RDRL SED C, Adelphi, MD 20783 USA. EM szhang@arl.army.mil RI Zhang, Sheng/A-4456-2012 OI Zhang, Sheng/0000-0003-4435-4110 NR 17 TC 13 Z9 15 U1 9 U2 58 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD JUN 1 PY 2010 VL 195 IS 11 SI SI BP 3684 EP 3688 DI 10.1016/j.jpowsour.2009.12.068 PG 5 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 566PW UT WOS:000275386100047 ER PT J AU Rupp, TL Wesensten, NJ Balkin, TJ AF Rupp, Tracy L. Wesensten, Nancy J. Balkin, Thomas J. TI Sleep history affects task acquisition during subsequent sleep restriction and recovery SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE chronic sleep restriction; learning; partial sleep deprivation; recovery; sleep extension ID DOSE-RESPONSE; PERFORMANCE; WAKEFULNESS AB P>The aim of the present study was to examine if sleep amount prior to sleep restriction mediated subsequent task acquisition on serial addition/subtraction and reaction time (RT) sub-tasks of the Automated Neuropsychological Assessment Metric. Eleven males and 13 females [mean (SD) age = 25 (6.5) years] were assigned to either an Extended [10 h time in bed (TIB)] (n = 12) or Habitual [Mean (SD) = 7.09 (0.7)] (n = 12) sleep group for 1 week followed by one baseline night, seven sleep restriction nights (3 h TIB) and five recovery nights (8 h TIB). Throughout baseline, restriction and recovery, mathematical and serial RT tasks were administered hourly each day (08:00-18:00 h). Math and serial RT throughput for each task (speed x accuracy product) was analysed using a mixed-model anova with fixed effects for sleep group, day and time-of-day followed by post hoc t-tests (Bonferroni correction). Math throughput improved for both groups during sleep restriction, but more so compared with baseline for the prior sleep Extended group versus the Habitual group during recovery. In sum, 1 week of sleep extension improved resilience during subsequent sleep restriction and facilitated task acquisition during recovery, demonstrating that nightly sleep duration exerts long-term (days, weeks) effects. C1 [Rupp, Tracy L.; Wesensten, Nancy J.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, Rm 2w88,503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM tracy.rupp@amedd.army.mil FU US Army Medical Research and Materiel Command FX This work was supported by the US Army Medical Research and Materiel Command. This material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official or as reflecting the position of the Department of the Army of the Department of Defense. NR 16 TC 13 Z9 13 U1 1 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD JUN PY 2010 VL 19 IS 2 BP 289 EP 297 DI 10.1111/j.1365-2869.2009.00800.x PG 9 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 597UB UT WOS:000277786300005 PM 20050993 ER PT J AU Ozaki, H Brechue, WF Sakamaki, M Yasuda, T Nishikawa, M Aoki, N Ogita, F Abe, T AF Ozaki, Hayao Brechue, William F. Sakamaki, Mikako Yasuda, Tomohiro Nishikawa, Masato Aoki, Norikazu Ogita, Futoshi Abe, Takashi TI Metabolic and cardiovascular responses to upright cycle exercise with leg blood flow reduction SO JOURNAL OF SPORTS SCIENCE AND MEDICINE LA English DT Article DE Aerobic exercise; doppler echocardiography; apparent exercise intensity; occlusion ID INTENSITY MUSCLE-CONTRACTIONS; RESISTANCE EXERCISE; HUMANS; ACTIVATION; PRESSURE; ISCHEMIA; CAPACITY; FITNESS; FATIGUE; KAATSU AB The purpose of this study was to examine the metabolic and cardiovascular response to exercise without (CON) or with (BFR) restricted blood flow to the muscles. Ten young men performed upright cycle exercise at 20, 40, and 60% of maximal oxygen uptake, VO(2max) in both conditions while metabolic and cardiovascular parameters were determined. Pre-exercise VO(2) was not different between CON and BFR. Cardiac output (Q) was similar between the two conditions as a 25% reduction in stroke volume (SV) observed in BFR was associated with a 23% higher heart rate (HR) in BFR compared to CON. As a result rate-pressure product (RPP) was higher in the BFR but there was no difference in mean arterial pressure (MAP) or total peripheral resistance (TPR). During exercise, VO(2) tended to increase with BFR (similar to 10%) at each workload. Q increased in proportion to exercise intensity and there were no differences between conditions. The increase in SV with exercise was impaired during BFR; being similar to 20% lower in BFR at each workload. Both HR and RPP were significantly greater at each workload with BFR. MAP and TPR were greater with BFR at 40 and 60% VO(2max). In conclusion, the BFR employed impairs exercise SV but central cardiovascular function is maintained by an increased HR. BFR appears to result in a greater energy demand during continuous exercise between 20 and 60% of control VO(2max); probably indicated by a higher energy supply and RPP. When incorporating BFR, HR and RPP may not be valid or reliable indicators of exercise intensity. C1 [Ozaki, Hayao; Sakamaki, Mikako; Yasuda, Tomohiro; Abe, Takashi] Univ Tokyo, Dept Human & Engineered Environm Studies, Grad Sch Frontier Sci, Kashiwa, Chiba, Japan. [Brechue, William F.] US Mil Acad, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Nishikawa, Masato; Aoki, Norikazu; Ogita, Futoshi] Natl Inst Fitness & Sports Kanoya, Dept Exercise Physiol, Kanoya, Japan. RP Abe, T (reprint author), Univ Tokyo, Dept Human & Engineered Environm Studies, Grad Sch Frontier Sci, 5-1-5 Kashiwanoha, Kashiwa, Chiba, Japan. EM ozaki.hayao@gmail.com; bill.brechue@usma.edu; mikako@h.k.u-tokyo.ac.jp; yasuda@h.k.u-tokyo.ac.jp; ogita@nifs-k.ac.jp; abe@k.u-tokyo.ac.jp RI Ozaki, Hayao/F-7741-2011 FU Japan Ministry of Education, Culture, Sports, Science, and Technology [15300221] FX The authors thank the students who participated in this study. We also thank Hiroyuki Oda and Ryoko Kawakami for their assistance in the testing of the study. This study was supported by Grant-in-aid 15300221 (to TA) from the Japan Ministry of Education, Culture, Sports, Science, and Technology. NR 29 TC 7 Z9 7 U1 1 U2 8 PU JOURNAL SPORTS SCIENCE & MEDICINE PI BURSA PA MEDICAL FACULTY ULUDAG UNIV, DEPT SPORTS MEDICINE, BURSA, 16059, TURKEY SN 1303-2968 J9 J SPORT SCI MED JI J. Sport. Sci. Med. PD JUN PY 2010 VL 9 IS 2 BP 224 EP 230 PG 7 WC Sport Sciences SC Sport Sciences GA 608ND UT WOS:000278590100009 PM 24149689 ER PT J AU Chang, MH Pang, T Pemy, M AF Chang, Mou-Hsiung Pang, Tao Pemy, Moustapha TI An approximation scheme for Black-Scholes equations with delays SO JOURNAL OF SYSTEMS SCIENCE & COMPLEXITY LA English DT Article DE Black-Scholes equation; finite difference; stochastic functional differential equations; viscosity solutions ID OPTION AB This paper addresses a finite difference approximation for an infinite dimensional Black-Scholes equation obtained by Chang and Youree (2007). The equation arises from a consideration of an European option pricing problem in a market in which stock prices and the riskless asset prices have hereditary structures. Under a general condition on the payoff function of the option, it is shown that the pricing function is the unique viscosity solution of the infinite dimensional Black-Scholes equation. In addition, a finite difference approximation of the viscosity solution is provided and the convergence results are proved. C1 [Chang, Mou-Hsiung] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. [Pang, Tao] N Carolina State Univ, Dept Math, Raleigh, NC 27695 USA. [Pemy, Moustapha] Towson Univ, Dept Math, Towson, MD 21252 USA. RP Chang, MH (reprint author), USA, Res Off, Div Math, POB 12211, Res Triangle Pk, NC 27709 USA. EM mouhsiung.chang@us.army.mil; tpang@ncsu.edu; mpemy@towson.edu FU US Army Research Office [W911NF-04-D-0003] FX This research is partially supported by a grant W911NF-04-D-0003 from the US Army Research Office. NR 25 TC 2 Z9 2 U1 0 U2 2 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1009-6124 J9 J SYST SCI COMPLEX JI J. Syst. Sci. Complex. PD JUN PY 2010 VL 23 IS 3 BP 438 EP 455 DI 10.1007/s11424-010-0139-6 PG 18 WC Mathematics, Interdisciplinary Applications SC Mathematics GA 621PF UT WOS:000279592400004 ER PT J AU Liu, K Ayers, P Howard, H Anderson, A AF Liu, Kun Ayers, Paul Howard, Heidi Anderson, Alan TI Influence of soil and vehicle parameters on soil rut formation SO JOURNAL OF TERRAMECHANICS LA English DT Article ID PHYSICAL-PROPERTIES; DISTURBANCE; COMPACTION; IMPACTS AB Soil and vehicle parameters have significant effects on soil rut formation A randomized design was used to investigate the effects of five treatments soil texture, soil moisture, vehicle type, turning radius and velocity, on rut depth, rut width and rut index, which measure the degree of soil disturbance This vehicle rutting study was conducted on four off-road military vehicles under two soil moisture conditions and two soil texture conditions at Fort Riley, Kansas. A GPS-based vehicle tracking system was used to track the vehicle dynamics, and rut measurements were taken manually SAS 9.1 was used to investigate the effects of soil and vehicle parameters on rut formation. Results show that all the vehicle parameters (vehicle type, weight, velocity and turning radius) and soil parameters (soil texture and moisture) are statistically significant to affect rut formation (C) 2009 ISTVS. Published by Elsevier Ltd. All rights reserved C1 [Liu, Kun; Ayers, Paul] Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. [Howard, Heidi; Anderson, Alan] USA, ERDC, CERL, Champaign, IL 61822 USA. RP Ayers, P (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM ayers@utk.edu FU US Army Corps of Engineers, Construction Engineering Research Laboratory; Environmental Security Technology Certification Program (ESTCP) [SI-0815] FX The authors thank Phil Woodford and Chris Otto of Fort Riley Military Installation for helping with coordination efforts and field assistance and expertise. The authors also thank the US Army Corps of Engineers, Construction Engineering Research Laboratory for Project support. The authors are also grateful to the Environmental Security Technology Certification Program (ESTCP) Project SI-0815 for providing support for this study. NR 22 TC 3 Z9 4 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD JUN PY 2010 VL 47 IS 3 BP 143 EP 150 DI 10.1016/j.jterra.2009.09.001 PG 8 WC Engineering, Environmental SC Engineering GA 610CM UT WOS:000278707500002 ER PT J AU Kelly, JJ Freeman, AF Wang, H Cowen, EW Kong, HH AF Kelly, Jeffrey J. Freeman, Alexandra F. Wang, Heng Cowen, Edward W. Kong, Heidi H. TI An Amish boy with recurrent ulcerations of the lower extremities, telangiectases of the hands, and chronic lung disease SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Editorial Material DE chronic lung disease; immunodeficiency; leg ulcers; prolidase deficiency; skin; telangiectasia; ulcers ID HYPER-IGE SYNDROME; PROLIDASE DEFICIENCY; MUTATION; IMINOPEPTIDURIA; THERAPY; ULCERS; PEPD C1 [Cowen, Edward W.; Kong, Heidi H.] NCI, Dermatol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. [Kelly, Jeffrey J.] Walter Reed Army Med Ctr, Dept Dermatol, Washington, DC 20307 USA. [Freeman, Alexandra F.] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA. [Wang, Heng] DDC Clin Special Needs Children, Middlefield, OH USA. RP Kong, HH (reprint author), NCI, Dermatol Branch, Ctr Canc Res, NIH, Bldg 10,Room 12N238,10 Ctr Dr,MSC 1908, Bethesda, MD 20892 USA. EM konghe@mail.nih.gov OI Kong, Heidi/0000-0003-4424-064X FU Intramural NIH HHS [Z99 CA999999] NR 19 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 2010 VL 62 IS 6 BP 1031 EP 1034 DI 10.1016/j.jaad.2009.12.038 PG 4 WC Dermatology SC Dermatology GA 599UW UT WOS:000277940300016 PM 20466176 ER PT J AU Inaba, K Branco, BC Rhee, P Blackbourne, LH Holcomb, JB Teixeira, PGR Shulman, I Nelson, J Demetriades, D AF Inaba, Kenji Branco, Bernardino C. Rhee, Peter Blackbourne, Lorne H. Holcomb, John B. Teixeira, Pedro G. R. Shulman, Ira Nelson, Janice Demetriades, Demetrios TI Impact of Plasma Transfusion in Trauma Patients Who Do Not Require Massive Transfusion SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID FRESH-FROZEN PLASMA; DAMAGE CONTROL RESUSCITATION; RED-BLOOD-CELLS; LIFE-THREATENING COAGULOPATHY; RESPIRATORY-DISTRESS-SYNDROME; LAST 60 YEARS; FLUID RESUSCITATION; AGGRESSIVE USE; EXSANGUINATION PROTOCOL; NEUTROPHIL ACTIVATION AB BACKGROUND: For trauma patients requiring massive blood transfusion, aggressive plasma usage has been demonstrated to confer a survival advantage. The aim of this study was to evaluate the impact of plasma administration in nonmassively transfused patients. STUDY DESIGN: Trauma patients admitted to a Level 1 trauma center (2000-2005) requiring a nonmassive transfusion (<10 U packed RBC [PRBC] within 12 hours of admission) were identified retrospectively. Propensity scores were calculated to match and compare patients receiving plasma in the first 12 hours with those who did not. RESULTS: The 1,716 patients (86.1% of 1,933 who received PRBC transfusion) received a nonmassive transfusion. After exclusion of 31 (1.8%) early deaths, 284 patients receiving plasma were matched to patients who did not. There was no improvement in survival with plasma transfusion (17.3% versus 14.1%; p = 0.30) irrespective of the plasma-to-PRBC ratio achieved. However, the overall complication rate was significantly higher for patients receiving plasma (26.8% versus 18.3%, odds ratio [OR] = 1.7; 95% CI, 1.1-2.4; p = 0.016). As the volume of plasma increased, an increase in complications was seen, reaching 37.5% for patients receiving >6 U. The ARDS rate specifically was also significantly higher in patients receiving plasma (9.9% versus 3.5%, OR = 3.0; 95% CI, 1.4-6.2; p = 0.004]. Patients receiving >6 U plasma had a 12-fold increase in ARDS, a 6-fold increase in multiple organ dysfunction syndrome, and a 4-fold increase in pneumonia and sepsis. CONCLUSIONS: For nonmassively transfused trauma patients, plasma administration was associated with a substantial increase in complications, in particular ARDS, with no improvement in survival. An increase in multiple organ dysfunction, pneumonia, and sepsis was likewise seen as increasing volumes of plasma were transfused. The optimal trigger for initiation of a protocol for aggressive plasma infusion warrants prospective evaluation. (J Am Coll Surg 2010;210:957-965. (C) 2010 by the American College of Surgeons) C1 [Inaba, Kenji; Branco, Bernardino C.; Teixeira, Pedro G. R.; Demetriades, Demetrios] Univ So Calif, Div Trauma & Surg Crit Care, Los Angeles, CA 90033 USA. [Rhee, Peter] Univ Arizona, Div Trauma Crit Care & Emergency Surg, Tucson, AZ USA. [Blackbourne, Lorne H.] USA, Inst Surg Res, San Antonio, TX USA. [Holcomb, John B.] Univ Texas Med Sch Houston, Div Acute Care Surg, Ctr Translat Injury Res, Houston, TX USA. [Shulman, Ira; Nelson, Janice] Univ So Calif, Med Ctr, Dept Pathol, Los Angeles, CA 90033 USA. RP Inaba, K (reprint author), Univ So Calif, Div Trauma & Surg Crit Care, 1200 N State St,Room CL5100, Los Angeles, CA 90033 USA. EM kinaba@surgery.usc.edu RI Teixeira, Pedro/H-2239-2011 OI Teixeira, Pedro/0000-0002-7258-7977 NR 57 TC 118 Z9 122 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD JUN PY 2010 VL 210 IS 6 BP 957 EP 965 DI 10.1016/j.jamcollsurg.2010.01.031 PG 9 WC Surgery SC Surgery GA 609IH UT WOS:000278649100010 PM 20510805 ER PT J AU Foley, DH Klein, TA Kim, HC Brown, T Wilkerson, RC Rueda, LM AF Foley, Desmond H. Klein, Terry A. Kim, Heung Chul Brown, Tracy Wilkerson, Richard C. Rueda, Leopoldo M. TI VALIDATION OF ECOLOGICAL NICHE MODELS FOR POTENTIAL MALARIA VECTORS IN THE REPUBLIC OF KOREA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Ecological niche models; distribution; malaria; mosquito; Korea ID PLASMODIUM-VIVAX MALARIA; SPECIES DISTRIBUTIONS; CHANGING PATTERNS; US FORCES; TRANSFERABILITY AB Data on molecularly identified adult and larval mosquitoes collected from 104 sites from the Republic of Korea (ROK) in 2007 were used to test the predictive ability of recently reported ecological niche models (ENMs) for 8 potential malaria vectors. The ENMs, based on the program Maxent and the least presence threshold criterion, predicted 100% of new collection locations for Anopheles sinensis, An. belenrae, An. pullus, and An. sineroides; 96% of locations for An. kleini; and 83% for An. lesteri, but were relatively unsuccessful for the infrequently collected non-Hyrcanus group species An. koreicus. and An. lindesayi japonicas. The ENMs produced with the use or Maxent had fewer omission errors than those using the Genetic Algorithm for Rule-Set Prediction program. The results emphasize the importance of independent test data for validation and improvement of ENMs, and lend support for the further development of ENMs for predicting the distribution of malaria vectors in the ROK. C1 [Foley, Desmond H.; Brown, Tracy; Wilkerson, Richard C.; Rueda, Leopoldo M.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. [Klein, Terry A.] Force Hlth Protect & Prevent Med, Unit 15281, APO, AP 96205 USA. RP Foley, DH (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 FU Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD; Walter Reed Army Institute of Research; Smithsonian Institution FX Funding for this work was provided by the Armed Forces Health Surveillance Center, Global Emerging Infections Surveillance and Response Systems, Silver Spring, MD. This research was performed under a Memorandum of Understanding between the Walter Reed Army Institute of Research and the Smithsonian Institution, with institutional support provided by both organizations. The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 18 TC 7 Z9 7 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSOC PI MOUNT LAUREL PA 15000 COMMERCE PARKWAY, SUITE C, MOUNT LAUREL, NJ 08054 USA SN 8756-971X EI 1943-6270 J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 2010 VL 26 IS 2 BP 210 EP 213 DI 10.2987/09-5939.1 PG 4 WC Entomology SC Entomology GA 618AA UT WOS:000279322100011 PM 20649131 ER PT J AU White, CE Batchinsky, AI Necsoiu, C Nguyen, R Walker, KP Chung, KK Wolf, SE Cancio, LC AF White, Christopher E. Batchinsky, Andriy I. Necsoiu, Corina Nguyen, Ruth Walker, Kerfoot P., III Chung, Kevin K. Wolf, Steven E. Cancio, Leopoldo C. TI Lower Interbreath Interval Complexity Is Associated With Extubation Failure in Mechanically Ventilated Patients During Spontaneous Breathing Trials SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 68th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY OCT 01-03, 2009 CL Pittsburgh, PA SP Amer Assoc Surg Trauma DE Mechanical ventilation; Weaning; Respiratory variability; Sample entropy; Humans ID HEART-RATE COMPLEXITY; VARIATIONAL ACTIVITY; APPROXIMATE ENTROPY; HUMAN RESPIRATION; TRAUMA PATIENTS; VARIABILITY; DYNAMICS; PATTERN; PREDICTION; SUPPORT AB Objective: To determine whether lower complexity of interbreath interval as measured with nonlinear analysis techniques will identify patients who fail to separate from mechanical ventilation after 30-minute spontaneous breathing trials ( SBTs). Methods: Respiratory waveforms from SBT of patients in surgical or burn intensive care units were recorded for later analysis. The decision to extubate was made by attending physician. Extubated patients were observed for 48 hours; during this time, reintubation or noninvasive positive pressure ventilation was considered as a failure. Analysis of waveform data by software was performed post hoc. Sample entropy ( SampEn) and other nonlinear measures were 48 hours of extubation. Results: Thirty-two patients ( 24 burn, 8 trauma/surgical admissions; mean age, 40.2 +/- 16.9 years; 26 men and 6 women) who were intubated >24 hours were extubated after SBT. Twenty-four patients were successfully separated from mechanical ventilation and eight failed. Age, gender, and mechanism of injury did not influence outcome. SampEn calculated for the two groups presented in this study was different with the cohort that failed extubation having a lower mean value ( 1.35 +/- 0.39 vs. 1.87 +/- 0.27; p < 0.001). Other nonlinear metrics were moved in concert with SampEn. The stationarity in the respiratory signal was not different between groups. Conclusion: In intubated patients, the interbreath interval in those who were successfully separated from mechanical ventilation was more irregular than those who failed, as measured by nonlinear techniques. When available at bedside, these metrics may be useful markers of pulmonary health and assist in clinical decision making. C1 [White, Christopher E.; Batchinsky, Andriy I.; Necsoiu, Corina; Nguyen, Ruth; Walker, Kerfoot P., III; Chung, Kevin K.; Wolf, Steven E.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP White, CE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM christopher.eric.white@us.army.mil RI Necsoiu, Corina/A-6255-2013; OI Wolf, Steven/0000-0003-2972-3440 FU NCATS NIH HHS [UL1 TR000149, KL2 TR000118]; NCRR NIH HHS [KL2 RR025766, UL RR025767, UL1 RR025767] NR 62 TC 10 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2010 VL 68 IS 6 BP 1310 EP 1316 DI 10.1097/TA.0b013e3181da90db PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 610ES UT WOS:000278714600009 PM 20539175 ER PT J AU Stinner, DJ Burns, TC Kirk, KL Ficke, JR AF Stinner, Daniel J. Burns, Travis C. Kirk, Kevin L. Ficke, James R. TI Return to Duty Rate of Amputee Soldiers in the Current Conflicts in Afghanistan and Iraq SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Return to Duty; Amputee Soldier ID OPERATION ENDURING FREEDOM; AMPUTATION; TRAUMA AB Background: The purpose of this study was to determine the percentage of amputee soldiers who sustained their injury during the current conflicts in Afghanistan and Iraq and have returned to duty. In addition, the authors plan to identify the factors that influence the amputee's likelihood to return to duty. Methods: The computerized records of amputee soldiers who presented to the Physical Evaluation Board between October 1, 2001 and June 1, 2006 were reviewed. This data were crossreferenced with the Military Amputee Database. The following variables were extracted: age, gender, pay grade, amputation level, and final disposition. Results: During the period reviewed, there were 395 major limb amputees that met inclusion criteria. Of those, 65 returned to active duty (16.5%). The average age of amputees returning to duty was more than 4 years older than those who separated from the service (31.4 vs. 27.2), p < 0.0001. Officers and senior enlisted personnel returned to duty at a higher rate (35.3% and 25.5%, respectively) when compared with junior enlisted personnel (7.0%), p < 0.0001. Those with multiple extremity amputations have the lowest return to duty rate at 3%, when compared with the overall return to duty rate for single extremity amputees (20%), p < 0.0001. Conclusion: During the 1980s, 11 of 469 amputees returned to active duty (2.3%). The number of amputees returning to duty has increased significantly, from 2.3% to 16.5%, due to advancements in combat casualty care and the establishment of centralized amputee centers. C1 [Stinner, Daniel J.] USA, Dept Regenerat Med, Inst Surg Res, San Antonio, TX 78234 USA. [Burns, Travis C.; Kirk, Kevin L.; Ficke, James R.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, San Antonio, TX USA. RP Stinner, DJ (reprint author), USA, Dept Regenerat Med, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM daniel.stinner@amedd.army.mil OI Stinner, Daniel/0000-0002-8981-6262 NR 15 TC 51 Z9 52 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2010 VL 68 IS 6 BP 1476 EP 1479 DI 10.1097/TA.0b013e3181bb9a6c PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 610ES UT WOS:000278714600039 PM 20068483 ER PT J AU Nunez, TC Young, PP Holcomb, JB Cotton, BA AF Nunez, Timothy C. Young, Pampee P. Holcomb, John B. Cotton, Bryan A. TI Creation, Implementation, and Maturation of a Massive Transfusion Protocol for the Exsanguinating Trauma Patient SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Trauma; Exsanguination; Hemorrhage; Massive transfusion; Protocol ID ACTIVATED FACTOR-VII; RED-BLOOD-CELL; DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; MULTIPLE ORGAN FAILURE; LIFE-THREATENING COAGULOPATHY; ADJUNCTIVE HEMORRHAGE CONTROL; COMBAT-RELATED CASUALTIES; CREW RESOURCE-MANAGEMENT; RECOMBINANT-FACTOR-VIIA AB The majority of trauma patients (> 90%) do not require any blood product transfusion and their mortality is < 1%. However, 3% to 5% of civilian trauma patients will receive a massive transfusion (MT), defined as > 10 units of packed red blood cells (PRBC) in 24 hours. In addition, more than 25% of these patients will arrive to emergency departments with evidence of trauma-associated coagulopathy. With this combination of massive blood loss and coagulopathy, it has become increasingly more common to transfuse early the trauma patients and with a combination of PRBC, plasma, and platelets. Given the inherent uncertainties common early in the care of patients with severe injuries, the efficient administration of massive amounts of PRBC and clotting factors tends to work best in a predefined, protocol driven system. Our purpose here is to (1) define the problem of massive hemorrhage and coagulopathy in the trauma patient, (2) identify which group of patients this type of protocol should be applied, (3) describe the extensive coordination required to implement this multispecialty MT protocol, (4) explain in detail how the MT was developed and implemented, and (5) emphasize the need for a robust performance improvement or quality improvement process to monitor the implementation of such a protocol and to help identify problems and deliver feedback in a "real-time" fashion. The successful implementation of such a complex process can only be accomplished in a multispecialty setting. Input and representation from departments of Trauma, Critical Care, Anesthesiology, Transfusion Medicine, and Emergency Medicine are necessary to successfully formulate (and implement) such a protocol. Once a protocol has been agreed upon, education of the entire nursing and physician staff is equally essential to the success of this effort. Once implemented, this process may lead to improved clinical outcomes and decreased overall blood utilization with extremely small wastage of vital blood products. C1 [Cotton, Bryan A.] Univ Texas Hlth Sci Ctr, Dept Surg, Div Acute Care Surg, Houston, TX 77030 USA. [Holcomb, John B.; Cotton, Bryan A.] Ctr Translat Injury Res, Houston, TX USA. [Young, Pampee P.] Tennessee Valley VA Med Ctr, Dept Pathol, Nashville, TN USA. [Young, Pampee P.] Vanderbilt Univ, Sch Med, Dept Pathol, Nashville, TN 37212 USA. [Nunez, Timothy C.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Cotton, BA (reprint author), Univ Texas Hlth Sci Ctr, Dept Surg, Div Acute Care Surg, 6410 Fannin,1100 UPB, Houston, TX 77030 USA. EM bryan.cotton@uth.tmc.edu FU NIGMS NIH HHS [P50 GM038529, P50 GM038529-19] NR 94 TC 51 Z9 51 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2010 VL 68 IS 6 BP 1498 EP 1505 DI 10.1097/TA.0b013e3181d3cc25 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 610ES UT WOS:000278714600042 PM 20539192 ER PT J AU Dickstein, BD Suvak, M Litz, BT Adler, AB AF Dickstein, Benjamin D. Suvak, Michael Litz, Brett T. Adler, Amy B. TI Heterogeneity in the Course of Posttraumatic Stress Disorder: Trajectories of Symptomatology SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID VEHICLE ACCIDENT SURVIVORS; TRAUMA-EXPOSED ADULTS; PSYCHOMETRIC PROPERTIES; RISK-FACTORS; PREDICTORS; METAANALYSIS; CHECKLIST; SYMPTOMS; EVENTS; COMBAT AB Unconditional and conditional trajectories of posttraumatic stress disorder (PTSD) symptomatology were examined using a sample of U.S. soldiers deployed on a NATO-led peacekeeping mission to Kosovo. Data were collected at 4 time points, ranging from the weeks leading up to deployment to 9-months postdeployment. Latent class growth analysis revealed 4 unique symptom trajectories: resilience, recovery, delayed, and unrealized anxiety. Variables identified as significant predictors of trajectory class included previous traumatic events, combat exposure, peacekeeping daily hassles, depression, alcohol use, aggressive behavior, stress reaction); and military rank. Results from this study add to the literature detailing the variability in PTSD course, as well as to the literature pertaining to predictors of PTSD onset and course. C1 [Litz, Brett T.] Boston Univ, Dept Psychol, VA Boston Healthcare Syst, Natl Ctr PTSD,Sch Med, Boston, MA 02215 USA. [Adler, Amy B.] USA, Med Res Unit Europe, Washington, DC USA. [Adler, Amy B.] Walter Reed Inst Res, Silver Spring, MD USA. RP Dickstein, BD (reprint author), Boston Dept Vet Affairs Med Ctr, Natl Ctr Posttraumat Stress Disorder, Behav Sci Div 116 B5, 150 S Huntington Ave, Boston, MA 02130 USA. EM Benjamin.Dickstein@va.gov NR 43 TC 76 Z9 76 U1 3 U2 18 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD JUN PY 2010 VL 23 IS 3 BP 331 EP 339 DI 10.1002/jts.20523 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 619HG UT WOS:000279419300004 PM 20564365 ER PT J AU Koch, TS Ching, BH Meyermann, MW Helsel, BS AF Koch, Troy S. Ching, Brian H. Meyermann, Mark W. Helsel, Bryan S. TI Percutaneous Fluoroscopically Guided Removal of a Deep Retroperitoneal Foreign Body with a Laparoscopic Trocar and Grasping Device SO JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Article ID BODIES; RETRIEVAL AB Traditionally, soft tissue foreign body removal is performed surgically. Superficial foreign body removal under ultrasonographic and fluoroscopic guidance has been reported. Herein, the authors report a case of percutaneous removal of a retroperitoneal foreign body under fluoroscopic guidance by using a modified laparoscopic trocar device and a laparoscopic grasping device. Iodinated contrast medium administered via the trocar device allowed visualization of the foreign body and distended the retroperitoneal space to allow for manipulation of the foreign body. The procedure was completed in a relatively short time and the patient made an excellent rapid postoperative recovery. C1 [Ching, Brian H.; Meyermann, Mark W.] Tripler Army Med Ctr, Dept Intervent Radiol, Honolulu, HI 96859 USA. [Koch, Troy S.] Tripler Army Med Ctr, Dept Radiol, Honolulu, HI 96859 USA. [Helsel, Bryan S.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Ching, BH (reprint author), Tripler Army Med Ctr, Dept Intervent Radiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM brian.ching@amedd.army.mil NR 10 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1051-0443 J9 J VASC INTERV RADIOL JI J. Vasc. Interv. Radiol. PD JUN PY 2010 VL 21 IS 6 BP 945 EP 947 DI 10.1016/j.jvir.2010.02.010 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA 607SY UT WOS:000278528100027 PM 20382545 ER PT J AU Harrison, BA Rayburn, WH Toliver, M Powell, EE Engber, BR Durden, LA Robbins, RG Prendergast, BF Whitt, PB AF Harrison, Bruce A. Rayburn, Walker H., Jr. Toliver, Marcee Powell, Eugene E. Engber, Barry R. Durden, Lance A. Robbins, Richard G. Prendergast, Brian F. Whitt, Parker B. TI Recent discovery of widespread Ixodes affinis (Acari: Ixodidae) distribution in North Carolina with implications for Lyme disease studies SO JOURNAL OF VECTOR ECOLOGY LA English DT Article DE North Carolina; Ixodes affinis; identification; distribution; hosts; Ixodes scapularis; Borrelia species ID WHITE-TAILED DEER; BORRELIA-BURGDORFERI; SOUTH-CAROLINA; TICKS ACARI; SEASONAL ACTIVITIES; SCAPULARIS ACARI; GEORGIA; RODENTS; HOST; VERTEBRATES AB Ixodes affinis, which is similar morphologically to Ixodes scapularis, is widely distributed in North Carolina. Collections have documented this species in 32 of 41 coastal plain counties, but no piedmont or mountain counties. This coastal plain distribution is similar to its distribution in Georgia and South Carolina, where it is considered an enzootic vector of Borrelia burgdorferi sensu stricto. An updated list of hosts for I. affinis in the U.S.A. is included, increasing the number to 15 mammal and one bird species. The presence of questing adults of I. affinis from April to November reinforces the need for confirmed identifications of suspected tick vectors of Borrelia spirochetes collected during warm months. Journal of Vector Ecology 35 (1): 174-179.2010. C1 [Harrison, Bruce A.; Toliver, Marcee; Powell, Eugene E.; Engber, Barry R.; Whitt, Parker B.] N Carolina Dept Environm & Nat Resources, Publ Hlth Pest Management, Mail Serv Ctr 1631, Raleigh, NC 27699 USA. [Durden, Lance A.] Georgia So Univ, Dept Biol, Statesboro, GA 30460 USA. [Robbins, Richard G.] Walter Reed Army Med Ctr, DPMIAC AFPMB, Washington, DC 20307 USA. [Prendergast, Brian F.] USN, Portsmouth, VA 23708 USA. [Prendergast, Brian F.] Marine Corps Public Hlth Ctr, Portsmouth, VA 23708 USA. RP Harrison, BA (reprint author), N Carolina Dept Environm & Nat Resources, Publ Hlth Pest Management, Mail Serv Ctr 1631, Raleigh, NC 27699 USA. RI Valle, Ruben/A-7512-2013 NR 31 TC 20 Z9 20 U1 0 U2 8 PU SOC VECTOR ECOLOGY PI CORONA PA 1966 COMPTON AVE, CORONA, CA 92881 USA SN 1081-1710 J9 J VECTOR ECOL JI J. Vector Ecol. PD JUN PY 2010 VL 35 IS 1 BP 174 EP 179 PG 6 WC Entomology SC Entomology GA 608HR UT WOS:000278574900024 PM 20618664 ER PT J AU Burke, R Barrera, R Lewis, M Kluchinsky, T Claborn, D AF Burke, R. Barrera, R. Lewis, M. Kluchinsky, T. Claborn, D. TI Septic tanks as larval habitats for the mosquitoes Aedes aegypti and Culex quinquefasciatus in Playa-Playita, Puerto Rico SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE Aedes aegypti; Culex quinquefasciatus; aquatic habitats; larvae; septic tanks ID WEST-NILE-VIRUS; NORTH QUEENSLAND; CENTRAL NIGERIA; FUNNEL TRAP; CULICIDAE; DIPTERA; ABUNDANCE; WELLS; WATER; PRODUCTIVITY AB Adult Aedes aegypti (Linnaeus) (Diptera: Culicidae) were previously recovered from emergence traps on septic tanks in southeastern Puerto Rico. In this study we quantified immature mosquito abundance and its relationship with structural variables of the septic tanks and chemical properties of the water containing raw sewage. A miniaturized floating funnel trap was used to sample 89 septic tanks for larvae in the Puerto Rican community of Playa-Playita. Aedes aegypti larvae were recovered from 18% of the sampled tanks (10.3 larvae per septic tank per day). Larval presence was positively associated with cracking of the septic tank walls and uncovered access ports. Larval abundance was positively associated with cracking of the septic tank walls and larger tank surface areas, and inversely associated with the total dissolved solids (TDS). Culex quinquefasciatus (Say) larvae were also recovered from 74% of the septic tanks (129.6 larvae per septic tank per day). Larval presence was negatively associated with TDS in the water and larval abundance was positively associated with cracking of the septic tank walls. A screened, plastic emergence trap was used to sample 93 septic tanks within the community for Ae. aegypti and Cx. quinquefasciatus adults. Aedes aegypti adults were recovered from 49% of the sampled tanks (8.7 adults per septic tank per day) and Cx. quinquefasciatus adults were recovered from 97% of the sampled tanks (155.5 adults per septic tank per day). Aedes aegypti adult presence was positively associated with cracking, uncapped openings and septic water pH. The Ae. aegypti adult counts were positively associated with cracking and inversely associated with TDS and conductivity. This study marks the first published record of the recovery of Ae. aegypti larvae from holding tanks containing raw sewage in the Caribbean region. Our study indicates that Ae. aegypti larvae are present in sewage water and that septic tanks have at least the potential to maintain dengue transmission during the dry season. C1 [Burke, R.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Burke, R.; Lewis, M.; Kluchinsky, T.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD USA. [Burke, R.; Barrera, R.] Ctr Dis Control & Prevent, Dengue Branch, San Juan, PR USA. [Kluchinsky, T.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen, MD USA. [Claborn, D.] Missouri State Univ, Dept Nursing, Springfield, MO USA. RP Burke, R (reprint author), Armed Forces Hlth Surveillance Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ronald.l.burke@amedd.army.mil FU USU Intramural Fund for Graduate Students; Department of Defense Global Emerging Infections Surveillance and Response System FX We thank Major Robert Lowen, Captain Michael Drulis and Captain Richard Pierce at the U.S. Army Center for Health Promotion and Preventive Medicine-North (Ft. Meade, MD) for their assistance with sampling subterranean water. We thank Captain Justin Devanna and Sergeant Robert Halstead at the Veterinary Treatment Facility at Fort Buchanan (San Juan, PR) for their assistance with logistics. We also thank Dr Cara Olsen of the Uniformed Services University (USU) (Bethesda, MD) for her help with the statistics and Dr Edward Mitre of the USU (Bethesda, MD) for his help with overseeing this project. The following persons significantly contributed to the field work and sample collection: Orlando Gonzalez, Manuel Amador, Gilberto Felix, Veronica Acevedo and Jesus Flores. Funding was provided through the USU Intramural Fund for Graduate Students and the Department of Defense Global Emerging Infections Surveillance and Response System. The authors declare no conflicts of interest. The opinions and assertions made by the authors do not reflect the official position or opinions of the Department of Defense, the Centers for Disease Control and Prevention or USU. NR 36 TC 28 Z9 31 U1 2 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD JUN PY 2010 VL 24 IS 2 BP 117 EP 123 DI 10.1111/j.1365-2915.2010.00864.x PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 600HI UT WOS:000277975700003 PM 20374477 ER PT J AU Turbyville, JC AF Turbyville, Joseph C. TI Applying principles of physics to the airway to help explain the relationship between asthma and gastroesophageal reflux SO MEDICAL HYPOTHESES LA English DT Article ID LOWER ESOPHAGEAL SPHINCTER; OBSTRUCTIVE SLEEP-APNEA; ALLERGIC RHINITIS; CHRONIC SINUSITIS; CHILDREN; DISEASE; PREVALENCE; SYMPTOMS; COPD; ASSOCIATION AB Gastroesophageal reflux (GER) and asthma have been linked, but the true nature of this relationship is incompletely understood. Most of the literature examining this association has implicated GER as the factor contributing to asthma. GER has also been linked to conditions of the upper airway like sinusitis and obstructive sleep apnea (OSA), and once again, usually presumed to be the causative factor. While GER seems to be capable of exacerbating airway disease, mounting evidence suggests that airway obstruction is a risk factor for developing GER. This article examines the principles of physics that predict what should occur given the anatomy of the airway and the esophagus, and provides multiple examples of disease associations that appear to support the hypothesis that airway obstruction is a significant risk factor for development of gastroesophageal reflux. Published by Elsevier Ltd. C1 [Turbyville, Joseph C.] Ireland Army Community Hosp, Dept Allergy Immunol, Ft Knox, KY 40121 USA. [Turbyville, Joseph C.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. RP Turbyville, JC (reprint author), Ireland Army Community Hosp, Dept Allergy Immunol, 851 Ireland Loop, Ft Knox, KY 40121 USA. EM joseph.c.turbyville@us.army.mil NR 54 TC 9 Z9 9 U1 1 U2 6 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD JUN PY 2010 VL 74 IS 6 BP 1075 EP 1080 DI 10.1016/j.mehy.2009.12.030 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 598UI UT WOS:000277863900029 PM 20080360 ER PT J AU Baggish, AL Yared, K Weiner, RB Wang, F Demes, R Picard, MH Hagerman, F Wood, MJ AF Baggish, Aaron L. Yared, Kibar Weiner, Rory B. Wang, Francis Demes, Robert Picard, Michael H. Hagerman, Fredrick Wood, Malissa J. TI Differences in Cardiac Parameters among Elite Rowers and Subelite Rowers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE EXERCISE-INDUCED CARDIAC REMODELING; ATHLETE'S HEART; ELITE ATHLETE; MYOCARDIAL FUNCTION; DIASTOLIC FUNCTION ID LEFT-VENTRICULAR HYPERTROPHY; ATHLETES HEART; ENDOTHELIAL FUNCTION; DIASTOLIC FUNCTION; AEROBIC FITNESS; LEFT ATRIAL; EXERCISE; ENDURANCE; DIMENSIONS; MORPHOLOGY AB BAGGISH, A. L., K. YARED, R. B. WEINER, F. WANG, R. DEMES, M. H. PICARD, F. HAGERMAN, and M. J. WOOD. Differences in Cardiac Parameters among Elite Rowers and Subelite Rowers. Med. Sci. Sports Exerc., Vol. 42, No. 6, pp. 1215-1220, 2010. There is significant individual variability in the cardiac adaptation that occurs in response to exercise training. Factors associated with this variability remain incompletely understood. To date, the relationship between the competition level at which athletes participate and their underlying cardiac parameters has not been explored. Purpose: The purpose of this study was to determine whether parameters of cardiac structure and function differ significantly among elite competitive rowers (ER), subelite competitive rowers (SR), and sedentary controls (C). Methods: Cardiac parameters were assessed in ER (n = 20), SR (n = 20), and C (n = 20) using two-dimensional, tissue Doppler, and speckled-tracking echocardiography. Results: Physiologic cardiac remodeling was present in both ER and SR as evidenced by the significant differences in the majority of structural and functional parameters in both rower groups when compared with C. When compared with SR, ER were found to have greater left ventricular (LV) end-diastolic volume (76 +/- 6 vs 71 +/- 8 mL.m(-2), P = 0.02), LV mass (150 +/- 11 vs 134 +/- 16 g.m(-2), P = 0.002), and right ventricular (RV) end-diastolic chamber dimensions (15.6 +/- 0.9 vs 13.9 perpendicular to 1.5 cm(2).m(-2), P < 0.001). Further, ER demonstrated significantly more enhancement of RV systolic function (peak strain = 36% +/- 7% vs 31% +/- 6%, P = 0.008) and late diastolic relaxation in both the LV (A' = 4.2 +/- 1.3 vs 3.2 +/- 0.9 cm.s(-1), P = 0.01) and the RV (A' = 6.6 +/- 1.4 vs 4.3 +/- 1.3 cm.s(-1), P < 0.001). Conclusions: Although cardiac remodeling occurs in both ER and SR, specific aspects of cardiac structure and function differ between rowers who compete at the elite and the subelite levels of sport. C1 [Baggish, Aaron L.; Yared, Kibar; Weiner, Rory B.; Picard, Michael H.; Wood, Malissa J.] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA. [Wang, Francis] Harvard Univ, Hlth Serv, Cambridge, MA 02138 USA. [Demes, Robert] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Hagerman, Fredrick] Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA. RP Baggish, AL (reprint author), Massachusetts Gen Hosp, Div Cardiol, Yawkey Bldg,Suite 5B,55 Fruit St, Boston, MA 02114 USA. EM abaggish@partners.org OI Picard, Michael/0000-0002-9264-3243 NR 40 TC 27 Z9 27 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 2010 VL 42 IS 6 BP 1215 EP 1220 DI 10.1249/MSS.0b013e3181c81604 PG 6 WC Sport Sciences SC Sport Sciences GA 596ZV UT WOS:000277725700022 PM 19997021 ER PT J AU Lester, ME Knapik, JJ Catrambone, D Antczak, A Sharp, MA Burrell, L Darakjy, S AF Lester, Mark E. Knapik, Joseph J. Catrambone, Daniel Antczak, Amanda Sharp, Marilyn A. Burrell, Lolita Darakjy, Salima TI Effect of a 13-Month Deployment to Iraq on Physical Fitness and Body Composition SO MILITARY MEDICINE LA English DT Article ID REPETITION MAXIMUM; WEIGHT-GAIN; MUSCLE MASS; RESISTANCE; STRENGTH; MEN; RELIABILITY; EXERCISE; SQUATS; ARMY AB This investigation evaluated the effects of a 13-month deployment to Iraq on body composition and selected fitness measures. Seventy-three combat arms soldiers were measured pre- and postdeployment. Body composition was assessed by dual X-ray absorptiometry (DXA). Strength was measured by single repetition maximum (1-RM) lifts on bench press and squat. Power was assessed by a bench throw and squat jump. Aerobic endurance was evaluated with a timed 2-mile run. Exercise and injury history were assessed by questionnaire. Upper and lower body strength improved by 7% and 8%, respectively (p <0.001). Upper body power increased 9% (p <0.001) and lean mass increased 3% (p <0.05). In contrast, aerobic performance declined 13% (p <0.001) and fat mass increased 9% (p <0.05). Fewer soldiers participated in aerobic exercise or sports during deployment (p <0.001). Unit commanders should be aware of potential fitness and body composition changes during deployment and develop physical training programs to enhance fitness following deployment. C1 [Lester, Mark E.; Catrambone, Daniel; Antczak, Amanda; Sharp, Marilyn A.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Knapik, Joseph J.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Burrell, Lolita; Darakjy, Salima] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Lester, ME (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. NR 26 TC 20 Z9 21 U1 0 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2010 VL 175 IS 6 BP 417 EP 423 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 607FS UT WOS:000278485100009 PM 20572474 ER PT J AU Lang, GM Pfister, EA Siemens, MJ AF Lang, Gary Morris Pfister, Elizabeth A. Siemens, Michelle J. TI Nursing Burnout: Cross-Sectional Study at a Large Army Hospital SO MILITARY MEDICINE LA English DT Article ID PATIENT SAFETY OUTCOMES; JOB-SATISFACTION; ORGANIZATIONAL-CLIMATE; REGISTERED NURSES; WORK ENVIRONMENTS; HEALTH OUTCOMES; UNITED-STATES; STAFF; PREDICTORS; NAVY AB The purpose of this study was to examine the levels of burnout among U.S. Army and civilian nursing personnel assigned to a large military treatment facility. Using a cross-sectional design, a convenience sample of eligible participants (n = 364) completed the Maslach Burnout Inventory. T-test and ordinal logistic regression were used to analyze data. Findings suggest that both groups were experiencing a moderate level of burnout. However, civilian nursing personnel demonstrated statistical lower levels of emotional exhaustion and depersonalization. Findings suggest that nursing personnel who worked the day shift, no more than 8 hours a day and had fewer patient care contacts with military personnel injured in Iraq or Afghanistan reported lower levels of emotional exhaustion and depersonalization. This study provides ideas for policy changes at medical treatment facilities that are experiencing similar challenges. C1 [Lang, Gary Morris; Pfister, Elizabeth A.; Siemens, Michelle J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lang, GM (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA. FU Department of Clinical Investigations, Walter Reed Army Medical Center, Washington, DC 20012 [08-75040] FX The Department of Clinical Investigations, Walter Reed Army Medical Center provided statistician support for this study. This study (Protocol/Work Unit Number: (08-75040) was funded with $3,000 from the Department of Clinical Investigations, Walter Reed Army Medical Center, Washington, DC 20012. NR 48 TC 4 Z9 4 U1 1 U2 10 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2010 VL 175 IS 6 BP 435 EP 441 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 607FS UT WOS:000278485100012 PM 20572477 ER PT J AU Loveless, BM Yermakova, A Christensen, DR Kondig, JP Heine, HS Wasieloski, LP Kulesh, DA AF Loveless, Bonnie M. Yermakova, Anastasiya Christensen, Deanna R. Kondig, John P. Heine, Henry S., III Wasieloski, Leonard P. Kulesh, David A. TI Identification of ciprofloxacin resistance by SimpleProbe (TM), High Resolution Melt and Pyrosequencing (TM) nucleic acid analysis in biothreat agents: Bacillus anthracis, Yersinia pestis and Francisella tularensis SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE SimpleProbe (TM); High Resolution Melt; Pyrosequence (TM); Ciprofloxacin antibiotic resistance ID DNA GYRASE; QUINOLONE RESISTANCE; ESCHERICHIA-COLI; TOPOISOMERASE-IV; STREPTOCOCCUS-PNEUMONIAE; DETERMINING REGION; MECHANISMS; FLUOROQUINOLONES; 4-QUINOLONES; MUTATIONS AB The potential for genetic modification of biological warfare agents makes rapid identification of antibiotic resistant strains critical for the implementation of suitable infection control measures. The fluorinated quinolone, ciprofloxacin, is an antibiotic effective for treating bacterial infections by inhibiting the enzyme activity of the DNA type II topoisomerases DNA gyrase and topoisomerase IV. The genes that encode the subunits of DNA gyrase (gyrA and gyrB) and topo IV (par C and parE) contain hotspots within an area known as the quinolone resistance-determining region (QRDR). Base pair changes within this region give rise to mutations that cause resistance to the antibiotic by altering amino acids within the enzymes. Ciprofloxacin-resistant (cipro(r)) strains of Bacillus anthracis, Yersinia pestis, and Francisella tularensis with one or more known mutations within the QRDR of gyrA, gyrB, parC, and parE genes were tested with SimpleProbe (TM) and High Resolution Melt (HRM) dye chemistries and Pyrosequencing (TM), genetic analysis to evaluate the ability to rapidly detect ciprofloxacin-induced mutations. While SimpleProbe (TM) and Pyrosequencing (TM) successfully identified all known mutants, the HRM assay identified all but those resulting from G <-> C or A <-> T substitutions. Published by Elsevier Ltd. C1 [Loveless, Bonnie M.; Christensen, Deanna R.; Kondig, John P.; Wasieloski, Leonard P.; Kulesh, David A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Yermakova, Anastasiya] SUNY Albany, Dept Biomed Sci, Albany, NY USA. [Heine, Henry S., III] USA, Med Res Inst Infect Dis, Div Microbiol, Ft Detrick, MD 21702 USA. RP Kulesh, DA (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM David.Kulesh@us.army.mil NR 28 TC 17 Z9 17 U1 0 U2 2 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD JUN PY 2010 VL 24 IS 3 BP 154 EP 160 DI 10.1016/j.mcp.2010.01.003 PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA 592ZJ UT WOS:000277420200007 PM 20100564 ER PT J AU Hurst, FP Abbott, KC AF Hurst, Frank P. Abbott, Kevin C. TI Rhabdomyolysis and acute kidney injury secondary to concomitant use of fluvastatin and rapamycin in a renal transplant recipient Reply SO NEPHROLOGY DIALYSIS TRANSPLANTATION LA English DT Letter ID CYCLOSPORINE; SIROLIMUS; OUTCOMES; SAFETY C1 [Hurst, Frank P.; Abbott, Kevin C.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Walter Reed Army Med Ctr,Nephrol Serv, Bethesda, MD 20814 USA. RP Hurst, FP (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Walter Reed Army Med Ctr,Nephrol Serv, Bethesda, MD 20814 USA. EM FRANK.HURST@US.ARMY.MIL NR 5 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0931-0509 J9 NEPHROL DIAL TRANSPL JI Nephrol. Dial. Transplant. PD JUN PY 2010 VL 25 IS 6 BP 2036 EP 2037 DI 10.1093/ndt/gfq154 PG 2 WC Transplantation; Urology & Nephrology SC Transplantation; Urology & Nephrology GA 627GL UT WOS:000280027400055 ER PT J AU Hipp, SJ Steffen-Smith, E Hammond, D Shih, JH Bent, R Warren, KE AF Hipp, S. J. Steffen-Smith, E. Hammond, D. Shih, J. H. Bent, R. Warren, K. E. TI PREDICTING OUTCOME OF CHILDREN WITH DIPG USING MULTIPARAMETRIC IMAGING SO NEURO-ONCOLOGY LA English DT Meeting Abstract CT 14th International Symposium on Pediatric Neuro-Oncology CY JUN 20-23, 2010 CL Vienna, AUSTRIA C1 [Hipp, S. J.; Steffen-Smith, E.; Shih, J. H.; Bent, R.; Warren, K. E.] Natl Canc Inst, Bethesda, MD USA. [Hipp, S. J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Hammond, D.] Natl Inst Hlth, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1522-8517 J9 NEURO-ONCOLOGY JI Neuro-Oncology PD JUN PY 2010 VL 12 IS 6 BP II9 EP II9 PG 1 WC Oncology; Clinical Neurology SC Oncology; Neurosciences & Neurology GA 611LW UT WOS:000278817700046 ER PT J AU Kenny, DJ Jennings, BM AF Kenny, Deborah J. Jennings, Bonnie M. TI Uniformed Services Nursing Preface SO NURSING CLINICS OF NORTH AMERICA LA English DT Editorial Material C1 [Kenny, Deborah J.] USA, Beth El Coll Nursing & Hlth Sci, Colorado Springs, CO 80918 USA. [Jennings, Bonnie M.] USA, Evans, GA 30809 USA. RP Kenny, DJ (reprint author), USA, Beth El Coll Nursing & Hlth Sci, 1420 Austin Bluffs Pkwy, Colorado Springs, CO 80918 USA. EM dkenny@uccs.edu; bmjennings@knology.net NR 0 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0029-6465 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD JUN PY 2010 VL 45 IS 2 BP XIII EP XV DI 10.1016/j.cnur.2010.03.011 PG 3 WC Nursing SC Nursing GA 618FT UT WOS:000279337600001 PM 20510696 ER PT J AU Vane, EAP Winthrop, TG Martinez, LM AF Vane, Elizabeth A. P. Winthrop, Thomas G. Martinez, Leonardo M. TI Implementing Basic Infection Control Practices in Disaster Situations SO NURSING CLINICS OF NORTH AMERICA LA English DT Article DE Basic infection control and prevention; Disaster planning; Disease transmission; Surveillance program; Military AB Infections, troublesome in even optimal health care environments, can be a source of serious and persistent concern for local populations and health care workers during a disaster, and in austere environments such as those found in Iraq and Afghanistan. For these scenarios, it is vital to have standard infection control practices in place and to have them used consistently. Only then will healthcare workers be able to contain the potential spread of disease and improve conditions for those affected. C1 [Winthrop, Thomas G.] Walter Reed Army Med Ctr, Perioperat Serv, Washington, DC 20307 USA. [Martinez, Leonardo M.] DeWitt Hlth Care Network, Ft Belvoir, VA 22060 USA. [Vane, Elizabeth A. P.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Perioperat Clin Nurse Specialist Program, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Vane, EAP (reprint author), Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Perioperat Clin Nurse Specialist Program, Grad Sch Nursing, Bldg E,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM Elizabeth.vane@usuhs.mil NR 18 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0029-6465 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD JUN PY 2010 VL 45 IS 2 BP 219 EP + DI 10.1016/j.cnur.2010.02.011 PG 14 WC Nursing SC Nursing GA 618FT UT WOS:000279337600011 PM 20510706 ER PT J AU SeriO-Melvin, M Yoder, LH Gaylord, KM AF SeriO-Melvin, Maria Yoder, Linda H. Gaylord, Kathryn M. TI Caring for Burn Patients at the United States Institute of Surgical Research: The Nurses' Multifaceted Roles SO NURSING CLINICS OF NORTH AMERICA LA English DT Article DE Burns; Nursing care; Outcomes research; Military ID ENDURING FREEDOM; GLUCOMETERS; INJURY; IRAQI AB Nursing plays a critical role in the comprehensive burn care delivered at the US Army Institute of Surgical Research, otherwise known as the US Army's Burn Center serving the Department of Defense. This center serves as a model for burn units nationally and internationally. It also provides a challenging and innovative work environment for military and civilian nurses. Nurses in the Burn Center contribute to innovations in acute, rehabilitative, and psychological care for patients with burns. This article provides an overview of the complex nursing care provided to burn patients treated at the Burn Center. C1 [Yoder, Linda H.] Univ Texas Austin, Sch Nursing, Austin, TX 78701 USA. [SeriO-Melvin, Maria; Gaylord, Kathryn M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Yoder, LH (reprint author), Univ Texas Austin, Sch Nursing, 1700 Red River, Austin, TX 78701 USA. EM lyoder@mail.nur.utexas.edu RI Sheini, Parisa/E-5889-2012 NR 33 TC 3 Z9 3 U1 0 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0029-6465 J9 NURS CLIN N AM JI Nurs. Clin. North Am. PD JUN PY 2010 VL 45 IS 2 BP 233 EP + DI 10.1016/j.cnur.2010.02.001 PG 17 WC Nursing SC Nursing GA 618FT UT WOS:000279337600012 PM 20510707 ER PT J AU McClung, JP Karl, JP AF McClung, James P. Karl, J. Philip TI Vitamin D and stress fracture: the contribution of vitamin D receptor gene polymorphisms SO NUTRITION REVIEWS LA English DT Review DE gene polymorphisms; stress fracture; vitamin D ID BONE-MINERAL DENSITY; D SUPPLEMENTATION; CIRCULATING OSTEOCALCIN; PARATHYROID-HORMONE; RISK-FACTORS; CALCIUM; WOMEN; PREVENTION; ALLELES; POSTMENOPAUSAL AB Vitamin D is essential for optimal bone health. Stress fracture is an overuse injury often occurring in active populations. Study results indicate an association exists between vitamin D status and the risk of stress fracture, and one intervention trial demonstrated a reduction in stress fractures in women consuming supplemental vitamin D and calcium. A recent study found that two polymorphisms in the vitamin D receptor (VDR), Fok1 and Bsm1, may increase the risk of stress fracture. Although further study is required, screening for VDR polymorphisms may become a tool for identifying individuals at increased risk of stress fracture during physical training. C1 [McClung, James P.; Karl, J. Philip] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM James.McClung@amedd.army.mil RI McClung, James/A-1989-2009; OI Karl, J. Philip/0000-0002-5871-2241 NR 29 TC 12 Z9 12 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0029-6643 J9 NUTR REV JI Nutr. Rev. PD JUN PY 2010 VL 68 IS 6 BP 365 EP 369 DI 10.1111/j.1753-4887.2010.00295.x PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 603GJ UT WOS:000278196400005 PM 20536781 ER PT J AU Mine, T Matsueda, S Gao, H Li, YF Wong, KK Peoples, GE Ferrone, S Ioannides, CG AF Mine, Takashi Matsueda, Satoko Gao, Hui Li, Yufeng Wong, Kwong-Kwok Peoples, George E. Ferrone, Soldano Ioannides, Constantin G. TI Created Gli-1 duplex short-RNA (i-Gli-RNA) eliminates CD44(Hi) progenitors of taxol-resistant ovarian cancer cells SO ONCOLOGY REPORTS LA English DT Article DE drug-resistance; cancer stem cell; Notch; Gli-1; micro-RNA ID STEM-CELLS; SELF-RENEWAL; TUMOR-GROWTH; NOTCH; EXPRESSION; DIFFERENTIATION; IDENTIFICATION; PATHWAYS; DIVISION; TARGET AB Notch and Hedgehog activate cell-cycle progression of adult and cancer stem cells. Notch is activated by DLL and Jag presents on neighboring cells. We investigated the effects of density of the Notch-activating ligand, Jag-1, and targeting Gli-1, in activation of division of paclitaxel/taxol-resistant, (PTXRes) ovarian cancer cells SKOV3 (SKOV3). We used the specific gamma-presenilin inhibitor, DAPT, to identify the specificity of activating signals for Notch-1 and created 'butterflyduplex-3548-Gli-1-inhibitory RNA' (i-Gli-1.RNA) to inhibit cell division. To accurately quantify kinetics of division, the expression of CD44 and CD24 was determined in each gated population of divided cells. CD44(High) proliferated when activated by Jag-1(Low) and poorly when activated by Jag-1(High). DAPT inhibited proliferation of cells activated by Jag-1(Low), and increased proliferation of cells activated by Jag-1 High. Only 5-10% of cells activated by Jag-1 High and Jag-1(Low) Low divided fast, polynomial, and symmetric. i-Gli-1.RNA eliminated more than 50% of the small CD44(High)/CD24(Neg) cells in divisions 3 and 4. This effect appeared specific compared with cells transfected with negative control siRNA. i-Gli-1.RNA had no effect on large CD44(High)/CD24(Neg) cells, but inhibited the population of CD44(High)/CD241(Low) cells. Expansion of CD44(High) inversely correlated with Jag-1 density on activating autologous tumor and fibrosarcoma cells. Created i-RNAs may decrease the resting CSC pool. Notch and Gli-1 signals play an important role in proliferation/division and survival of cancer stem cells. Targeting Notch-1 through its enhancer Gl-1, should be significant for novel treatments to eliminate taxol-resistant cancer stem cells (CSC). i.Gli-1 RNA should be more effective if used together with Taxol. C1 [Mine, Takashi; Matsueda, Satoko; Wong, Kwong-Kwok; Ioannides, Constantin G.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. [Gao, Hui] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Houston, TX 77030 USA. [Li, Yufeng] Univ Texas MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX 77030 USA. [Li, Yufeng] Univ Texas MD Anderson Canc Ctr, Grad Sch Biomed Sci, Houston, TX 77030 USA. [Ioannides, Constantin G.] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA. [Peoples, George E.] DOD Canc Ctr, Brooke Army Med Ctr, Dept Surg, Houston, TX USA. [Ferrone, Soldano] Univ Pittsburgh, Dept Surg, Inst Canc, Pittsburgh, PA USA. [Ferrone, Soldano] Univ Pittsburgh, Dept Pathol & Immunol, Inst Canc, Pittsburgh, PA USA. [Mine, Takashi] Kurume Univ, Sch Med, Dept Immunol, Kurume, Fukuoka 830, Japan. [Mine, Takashi] Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka 830, Japan. RP Ioannides, CG (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA. EM mine@med.kurume-u.ac.jp; cioannid@mdanderson.org OI Wong, Kwong-Kwok/0000-0002-0375-6669 FU DOD [01-1-0299]; Apthera Corporation; Eustathios and Euphrosina Maroulis Memorial Fund; European Union; 21st Century Fund; Kurume University, Japan FX We thank Dr Juergen Knoblich (University of Vienna, Austria) for advice and James Reuben (MDACC) for research support. This study was supported by the DOD Grant-01-1-0299, Licensing Funds from Apthera Corporation, Eustathios and Euphrosina Maroulis Memorial Fund, European Union 'Socrates' and 'Jean Monet' Grant Programs to C.G. loannides and the 21st Century Fund, and Kurume University, Japan (T. Mine). NR 28 TC 13 Z9 13 U1 0 U2 5 PU SPANDIDOS PUBL LTD PI ATHENS PA POB 18179, ATHENS, 116 10, GREECE SN 1021-335X J9 ONCOL REP JI Oncol. Rep. PD JUN PY 2010 VL 23 IS 6 BP 1537 EP 1543 DI 10.3892/or_00000793 PG 7 WC Oncology SC Oncology GA 594HJ UT WOS:000277526800007 PM 20428807 ER PT J AU Teitelbaum, ME Nair, R O'Brien, DJ Wetzel, ED Goossen, KW AF Teitelbaum, Michael E. Nair, Rohit O'Brien, Daniel J. Wetzel, Eric D. Goossen, Keith W. TI Cost-effective integration of plastic optical fiber and total internal reflection mirrors in printed circuit boards for parallel optical interconnects SO OPTICAL ENGINEERING LA English DT Article DE parallel optical interconnects; plastic optical fiber; optical interconnects; optical printed circuit board ID 45-DEGREES-ENDED CONNECTION RODS; WAVE-GUIDE; TECHNOLOGIES; VLSI AB A novel method of integrating a total internal reflection (TIR) mirror into an optical waveguide embedded in a printed circuit board (PCB) was demonstrated for application in chip-to-chip optical interconnects. Plastic optical fiber (POF) was placed into channels that were mechanically machined into FR-4 composite plates. The TIR mirror was created by a second mechanical machining. The mirror loss was measured to be approximately -1.6 dB per reflection. The use of POF resulted in attenuation losses in the waveguide over an order of magnitude lower than what is obtainable with typical planar waveguides that are integrated into PCBs. Monte Carlo ray tracing was used to determine the theoretical efficiency of the system as well as cross talk between channels due to optical device alignment tolerances. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3447921] C1 [Teitelbaum, Michael E.; Nair, Rohit; Goossen, Keith W.] Univ Delaware, Newark, DE 19716 USA. [O'Brien, Daniel J.; Wetzel, Eric D.] USA, Res Lab, Multifunct Mat Branch, AMSRD ARL WM MA, Aberdeen Proving Ground, MD 21005 USA. RP Teitelbaum, ME (reprint author), Univ Delaware, 140 Evans Hall, Newark, DE 19716 USA. EM mt@udel.edu NR 32 TC 2 Z9 2 U1 0 U2 4 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 2010 VL 49 IS 6 AR 065401 DI 10.1117/1.3447921 PG 7 WC Optics SC Optics GA 636OH UT WOS:000280746600032 ER PT J AU Cohen, SP AF Cohen, Steven P. TI Benzodiazepines for neuropathic back pain: When the cure is worse than the disease SO PAIN LA English DT Editorial Material ID CLINICAL-PRACTICE GUIDELINE; RESEARCH TRIAL SPORT; NONOPERATIVE TREATMENT; COST-EFFECTIVENESS; DISC HERNIATION; MEDICATION C1 [Cohen, Steven P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD 21029 USA. RP Cohen, SP (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. EM scohen40@jhmi.edu NR 22 TC 3 Z9 3 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3959 J9 PAIN JI Pain PD JUN PY 2010 VL 149 IS 3 BP 424 EP 425 DI 10.1016/j.pain.2010.03.038 PG 2 WC Anesthesiology; Clinical Neurology; Neurosciences SC Anesthesiology; Neurosciences & Neurology GA 598AS UT WOS:000277804700005 PM 20382475 ER PT J AU Xiang, Z Rosenthal, BM He, YS Wang, WL Wang, H Song, JL Shen, PQ Li, ML Yang, ZQ AF Xiang, Zheng Rosenthal, Benjamin M. He, Yongshu Wang, Wenlin Wang, Hong Song, Jingling Shen, Pei-Qing Li, Ma-Lin Yang, Zhaoqing TI Sarcocystis tupaia, sp nov., a new parasite species employing treeshrews (Tupaiidae, Tupaia belangeri chinensis) as natural intermediate hosts SO PARASITOLOGY INTERNATIONAL LA English DT Article DE Sarcocystis; Treeshew; 18s rDNA; Morphology ID RIBOSOMAL-RNA GENE; OPOSSUMS DIDELPHIS-VIRGINIANA; CAMELS CAMELUS-DROMEDARIUS; BUFFALO BUBALUS-BUBALIS; WATER-BUFFALO; LIFE-CYCLE; TOXOPLASMA-GONDII; DEFINITIVE HOSTS; CYST MORPHOLOGY; RFLP ANALYSIS AB The range of vertebrates that serve as intermediate hosts for parasites in the genus Sarcocystis remains incompletely defined. Here, we provide the first report of infections in treeshrews, describe the morphology of encysted parasites using light and transmission electron microscopy, and place this agent within a phylogenetic context by sequencing and comparing its 18 S ribosomal DNA to that of related parasites. Muscle infections were diagnosed in four of 45 wild treeshrews captured in the vicinity of Kunming, Yunnan Province, Mainland China. Thread-like cysts (10.773 +/- 2.411 mm in length, 0.106 +/- 0.009 mm in width) had walls (0.538-0.746 mu m thick) that lacked perpendicular protrusions. The interior of the cyst was packed full with cyst merozoites, the shape of which was typical of Sarcocystis. The primary cyst wall consisted of a thin membrane supported by osmiophilic material, 31-60 nm in thickness. The ground substance was about 105526 nm thickness. Cysts conformed to typical of 'type 1' sarcocysts. Freshly examined and frozen specimens did not differ in their cyst wall structure, however, the appearance of bradyzoites did differ: the conoid, rhoptries and micronemes were all visible in fresh bradyzoites; in stored bradyzoites, by contrast, the rhoptries appeared smaller, and although the conoid was visible, the micronemes were not. 18 S rRNA gene was distinct from any previously reported sequence in GenBank. Their genetic and morphological uniformity suggest that these parasites, derived from treeshrews, represent a single biological species. Sarcocystis tupaia, sp. nov. (C) 2009 Elsevier Ireland Ltd. All rights reserved. C1 [Xiang, Zheng; Wang, Wenlin; Wang, Hong; Yang, Zhaoqing] Kunming Med Univ, Dept Parasitol, Kunming 650031, Yunnan, Peoples R China. [Rosenthal, Benjamin M.] USA, Dept Agr, Anim Parasit Dis Lab, Agr Res Serv, Beltsville, MD 20705 USA. [He, Yongshu] Kunming Med Univ, Dept Biol, Kunming 650031, Yunnan, Peoples R China. [Song, Jingling] Kunming Med Univ, Elect Microscopy Dept, Kunming 650031, Yunnan, Peoples R China. [Shen, Pei-Qing] Off Lab Anim Management Yunnan Prov, Kunming 650031, Yunnan, Peoples R China. [Li, Ma-Lin] Kunming Med Univ, Lab Pharmacol Nat Prod Yunnan Prov, Kunming 650031, Yunnan, Peoples R China. RP Yang, ZQ (reprint author), Kunming Med Univ, Dept Parasitol, Kunming 650031, Yunnan, Peoples R China. EM limalinb@vip.163.com; zhaoqingy@yahoo.com OI Rosenthal, Benjamin/0000-0002-0224-3773 FU Project for Establishing Yunnan Facilities and Information Infrastructure for Science and Technology [2006PT07-1]; National Natural Science Foundation of China [30560022] FX We thank Lin Lei, Fang Yang, Lijun Yang, Xi Chen Cuiying Li, Jin Zeng for helping in sample collection. This study was supported by Project for Establishing Yunnan Facilities and Information Infrastructure for Science and Technology (No. 2006PT07-1). Dr. Zhaoqing Yang is supported by The National Natural Science Foundation of China (No. 30560022). NR 63 TC 4 Z9 5 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 1383-5769 J9 PARASITOL INT JI Parasitol. Int. PD JUN PY 2010 VL 59 IS 2 BP 128 EP 132 DI 10.1016/j.parint.2009.12.003 PG 5 WC Parasitology SC Parasitology GA 663EW UT WOS:000282866800004 PM 20026242 ER PT J AU Wessler, J Crouch, G Bleyer, A Merino, M AF Wessler, Jacob Crouch, Gary Bleyer, Archie Merino, Margret TI LAGTIME TO ONCOLOGIC DIAGNOSES: A COMPARISON BETWEEN MILITARY AND NON-MILITARY HEALTHCARE SYSTEMS SO PEDIATRIC BLOOD & CANCER LA English DT Meeting Abstract C1 [Wessler, Jacob; Crouch, Gary; Bleyer, Archie; Merino, Margret] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1545-5009 J9 PEDIATR BLOOD CANCER JI Pediatr. Blood Cancer PD JUN PY 2010 VL 54 IS 6 BP 849 EP 850 PG 2 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 578JT UT WOS:000276290300225 ER PT J AU Cork, DJ Lembark, S Tovanabutra, S Robb, ML Kim, JH AF Cork, Douglas J. Lembark, Steven Tovanabutra, Sodsai Robb, Merlin L. Kim, Jerome H. TI W-Curve Alignments for HIV-1 Genomic Comparisons SO PLOS ONE LA English DT Article ID CHAOS GAME REPRESENTATION; IMMUNODEFICIENCY-VIRUS TYPE-1; GRAPHICAL REPRESENTATION; NEUTRALIZING ANTIBODIES; DNA-SEQUENCES AB Background: The W-curve was originally developed as a graphical visualization technique for viewing DNA and RNA sequences. Its ability to render features of DNA also makes it suitable for computational studies. Its main advantage in this area is utilizing a single-pass algorithm for comparing the sequences. Avoiding recursion during sequence alignments offers advantages for speed and in-process resources. The graphical technique also allows for multiple models of comparison to be used depending on the nucleotide patterns embedded in similar whole genomic sequences. The W-curve approach allows us to compare large numbers of samples quickly. Method: We are currently tuning the algorithm to accommodate quirks specific to HIV-1 genomic sequences so that it can be used to aid in diagnostic and vaccine efforts. Tracking the molecular evolution of the virus has been greatly hampered by gap associated problems predominantly embedded within the envelope gene of the virus. Gaps and hypermutation of the virus slow conventional string based alignments of the whole genome. This paper describes the W-curve algorithm itself, and how we have adapted it for comparison of similar HIV-1 genomes. A treebuilding method is developed with the W-curve that utilizes a novel Cylindrical Coordinate distance method and gap analysis method. HIV-1 C2-V5 env sequence regions from a Mother/Infant cohort study are used in the comparison. Findings: The output distance matrix and neighbor results produced by the W-curve are functionally equivalent to those from Clustal for C2-V5 sequences in the mother/infant pairs infected with CRF01_AE. Conclusions: Significant potential exists for utilizing this method in place of conventional string based alignment of HIV-1 genomes, such as Clustal X. With W-curve heuristic alignment, it may be possible to obtain clinically useful results in a short time-short enough to affect clinical choices for acute treatment. A description of the W-curve generation process, including a comparison technique of aligning extremes of the curves to effectively phase-shift them past the HIV-1 gap problem, is presented. Besides yielding similar neighbor-joining phenogram topologies, most Mother and Infant C2-V5 sequences in the cohort pairs geometrically map closest to each other, indicating that W-curve heuristics overcame any gap problem. C1 [Cork, Douglas J.; Tovanabutra, Sodsai; Robb, Merlin L.; Kim, Jerome H.] US Mil HIV Res Program, Rockville, MD USA. [Cork, Douglas J.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. [Cork, Douglas J.] IIT, Chicago, IL 60616 USA. [Lembark, Steven] Workhorse Comp, Woodhaven, NY USA. [Robb, Merlin L.; Kim, Jerome H.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. RP Cork, DJ (reprint author), US Mil HIV Res Program, Rockville, MD USA. EM dcork@hivresearch.org FU HIV-1 Research Project (MHRP) [W81XWH-07-2-0067-P00001]; Henry Jackson Foundation (HJF); Workhorse Computing; Military Medicine, Inc.; U.S. Department of Defense (DOD); NICHD [R01 HD34343-03] FX Funding: Military HIV-1 Research Project (MHRP)/Henry Jackson Foundation (HJF) and Workhorse Computing. This work was funded by MHRP (Military HIV-1 Research Project) cooperative agreement (W81XWH-07-2-0067-P00001) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the U.S. Department of Defense (DOD). The cohort work was supported through NICHD by R01 HD34343-03 and partly by a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the U.S. Dept. of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 27 TC 2 Z9 2 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JUN 1 PY 2010 VL 5 IS 6 AR e10829 DI 10.1371/journal.pone.0010829 PG 11 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 603QF UT WOS:000278222400003 PM 20532248 ER PT J AU Spadafora, C Awandare, GA Kopydlowski, KM Czege, J Moch, JK Finberg, RW Tsokos, GC Stoute, JA AF Spadafora, Carmenza Awandare, Gordon A. Kopydlowski, Karen M. Czege, Jozsef Moch, J. Kathleen Finberg, Robert W. Tsokos, George C. Stoute, Jose A. TI Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum SO PLOS PATHOGENS LA English DT Article ID INVASION PATHWAYS; GLYCOPHORIN-A; MONOCLONAL-ANTIBODIES; MOUSE ERYTHROCYTES; MALARIA PARASITES; HUMAN MACROPHAGES; TYPE-1 CR-1; HETEROGENEITY; MECHANISM; PROTEINS AB Plasmodium falciparum is a highly lethal malaria parasite of humans. A major portion of its life cycle is dedicated to invading and multiplying inside erythrocytes. The molecular mechanisms of erythrocyte invasion are incompletely understood. P. falciparum depends heavily on sialic acid present on glycophorins to invade erythrocytes. However, a significant proportion of laboratory and field isolates are also able to invade erythrocytes in a sialic acid-independent manner. The identity of the erythrocyte sialic acid-independent receptor has been a mystery for decades. We report here that the complement receptor 1 (CR1) is a sialic acid-independent receptor for the invasion of erythrocytes by P. falciparum. We show that soluble CR1 (sCR1) as well as polyclonal and monoclonal antibodies against CR1 inhibit sialic acid-independent invasion in a variety of laboratory strains and wild isolates, and that merozoites interact directly with CR1 on the erythrocyte surface and with sCR1-coated microspheres. Also, the invasion of neuraminidase-treated erythrocytes correlates with the level of CR1 expression. Finally, both sialic acid-independent and dependent strains invade CR1 transgenic mouse erythrocytes preferentially over wild-type erythrocytes but invasion by the latter is more sensitive to neuraminidase. These results suggest that both sialic acid-dependent and independent strains interact with CR1 in the normal red cell during the invasion process. However, only sialic acid-independent strains can do so without the presence of glycophorin sialic acid. Our results close a longstanding and important gap in the understanding of the mechanism of erythrocyte invasion by P. falciparum that will eventually make possible the development of an effective blood stage vaccine. C1 [Spadafora, Carmenza; Tsokos, George C.; Stoute, Jose A.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. [Spadafora, Carmenza; Tsokos, George C.; Stoute, Jose A.] Walter Reed Army Inst Res, Div Mil Casualty Res, Dept Cellular Injury, Silver Spring, MD USA. [Spadafora, Carmenza] Inst Invest Cient & Serv Alta Tecnol AIP INDICASA, Ciudad Del Saber, Clayton, Panama. [Awandare, Gordon A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. [Kopydlowski, Karen M.; Moch, J. Kathleen] Walter Reed Army Inst Res, Dept Parasitol, Div Expt Therapeut, Silver Spring, MD USA. [Czege, Jozsef] Uniformed Serv Univ Hlth Sci, Biomed Instrumentat Ctr, Bethesda, MD 20814 USA. [Finberg, Robert W.] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA USA. [Tsokos, George C.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA. [Stoute, Jose A.] Penn State Univ, Coll Med, Dept Med, Div Infect Dis & Epidemiol, Hershey, PA USA. RP Spadafora, C (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA. EM jstoute@psu.edu OI Spadafora, Carmenza/0000-0002-3002-9467; Awandare, Gordon/0000-0002-8793-3641 FU National Heart Lung and Blood Institute [(HL 71502]; US Army Military Infectious Disease Research; Fogarty International Center [1 D43 TW06239]; Uniformed Services University of Health Sciences, Bethesda, MD; Secretari a Nacional de Ciencia y Tecnologia (SENACYT), Republica de Panama FX This study was supported in part by a grant from the National Heart Lung and Blood Institute (HL 71502, PI Jose A. Stoute) and by the US Army Military Infectious Disease Research Program (PI Jose A. Stoute). Carmenza Spadafora was supported in part by a training grant from the Fogarty International Center (1 D43 TW06239, PI Jose A. Stoute), by intramural funds from the Uniformed Services University of Health Sciences, Bethesda, MD, and a training grant from the Secretari a Nacional de Ciencia y Tecnologia (SENACYT), Republica de Panama. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 41 TC 44 Z9 44 U1 1 U2 2 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD JUN PY 2010 VL 6 IS 6 AR e1000968 DI 10.1371/journal.ppat.1000968 PG 13 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 624GX UT WOS:000279806300041 PM 20585558 ER PT J AU Helfstein, S AF Helfstein, Scott TI Friends Don't Let Friends Proliferate SO POLITICAL SCIENCE QUARTERLY LA English DT Article ID NUCLEAR PROLIFERATION; FOREIGN-POLICY; MULTILATERAL SANCTIONS; REGIME CHANGE; COOPERATION; NONPROLIFERATION C1 [Helfstein, Scott] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. [Helfstein, Scott] US Mil Acad, Combating Terrorism Ctr, West Point, NY USA. RP Helfstein, S (reprint author), US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. NR 83 TC 0 Z9 0 U1 0 U2 2 PU ACAD POLITICAL SCIENCE PI NEW YORK PA 475 RIVERSIDE DRIVE, SUITE 1274, NEW YORK, NY 10115-1274 USA SN 0032-3195 J9 POLIT SCI QUART JI Polit. Sci. Q. PD SUM PY 2010 VL 125 IS 2 BP 281 EP 307 PG 27 WC Political Science SC Government & Law GA 612GU UT WOS:000278885600005 ER PT J AU Klapotke, TM Radies, H Stierstorfer, J Tarantik, KR Chen, G Nagori, A AF Klapoetke, Thomas M. Radies, Hendrik Stierstorfer, Joerg Tarantik, Karina R. Chen, Gary Nagori, Amita TI Coloring Properties of Various High-Nitrogen Compounds in Pyrotechnic Compositions SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article; Proceedings Paper CT 36th International Pyrotechnics Seminar CY AUG, 2009 CL Rotterdam, NETHERLANDS DE Nitrogen-Rich; Perchlorate-Free; Pyrotechnics; Strontium Salts AB Strontium salts are widely used in red flame pyrotechnic compositions, usually combined with perchlorate salts as oxidizer. The potential environmental impact of perchlorate could be avoided by using high-nitrogen compounds. Therefore, the following nitrogen-rich strontium salts were prepared and characterized: strontium tetrazolate pentahydrate (1), strontium 1-methyl-5-nitriminotetrazolate monohydrate (2), and strontium 1-(2-chloroethyl)-5-nitriminotetrazolate monohydrate (3). Their combustion behavior and both color intensity and purity were investigated in pyrotechnics. These results were compared with the US Army in-service signal formulation. Pyrotechnic compositions which are used for producing green flame colors contain barium salts, usually highly water-soluble and toxic barium nitrate, Ba(NO(3))(2). In this research project copper-based colorants with energetic anions or ligands were developed. The compounds diammine bis(tetrazolato)amine copper(II) (4), diaqua copper(II) di(1-methyl-5-aminotetrazole) nitrate (5), diaqua copper(II) tetra(1-methyl-5-aminotetrazole) nitrate (6), and tetrammine copper(II) dinitramide (7) were synthesized and characterized. C1 [Klapoetke, Thomas M.; Radies, Hendrik; Stierstorfer, Joerg; Tarantik, Karina R.] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany. [Klapoetke, Thomas M.] Univ Maryland, Dept Mech Engn, Ctr Energet Concepts Dev, UMD, College Pk, MD 20742 USA. [Chen, Gary; Nagori, Amita] US ARMY RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Klapotke, TM (reprint author), Univ Munich, Dept Chem & Biochem, Butenandtstr 5-13, D-81377 Munich, Germany. EM tmk@cup.uni-muenchen.de RI Stierstorfer, Joerg/B-5261-2015; Klapoetke, Thomas/B-6055-2014 OI Stierstorfer, Joerg/0000-0002-2105-1275; Klapoetke, Thomas/0000-0003-3276-1157 NR 23 TC 26 Z9 27 U1 3 U2 26 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 2010 VL 35 IS 3 BP 213 EP 219 DI 10.1002/prep.201010018 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 620CM UT WOS:000279476600004 ER PT J AU De Lucia, FC Gottfried, JL AF De Lucia, Frank C., Jr. Gottfried, Jennifer L. TI Characterization of a Series of Nitrogen-Rich Molecules using Laser Induced Breakdown Spectroscopy SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Energetic Materials; Emission Spectroscopy; LIBS; Plasma Chemistry ID INDUCED PLASMA SPECTROSCOPY; ENERGETIC MATERIALS; SPECTROMETRY; EXPLOSIVES; RESIDUES; FUTURE; DISCRIMINATION; SALTS; LIBS AB A series of nitrogen-rich molecules, such as 5-aminotetrazolium nitrate (HAT-NO(3)) and hydrazinebistetrazole (HBT), bis(2,2,2-trinitroethyl)-hydrazodicarboxylate (BTHC), cyclotrimethylene trinitramine (RDX), trinitrotoluene (TNT), melamine, sucrose, and L-glutamine were studied using laser-induced breakdown spectroscopy (LIBS). The atomic emission intensities and intensity ratios of the constituent elements from the LIBS spectrum were shown to correlate with the mole fractions and stoichiometries of the molecules. In addition, the amount of oxygen present in the molecule influenced the emission intensities of molecular fragments such as C(2). Finally, we used principal components analysis to analyze the data from the LIBS spectra and separate the different organic molecules based on the atomic emission intensities and ratios. C1 [De Lucia, Frank C., Jr.; Gottfried, Jennifer L.] USA, Res Lab, Aberdeen Pround, MD 21005 USA. RP De Lucia, FC (reprint author), USA, Res Lab, Aberdeen Pround, MD 21005 USA. EM fdelucia@arl.army.mil RI Gottfried, Jennifer/G-6333-2010; De Lucia, Frank/D-5630-2012 NR 31 TC 27 Z9 27 U1 3 U2 21 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 2010 VL 35 IS 3 BP 268 EP 277 DI 10.1002/prep.201000009 PG 10 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 620CM UT WOS:000279476600012 ER PT J AU Ding, XZ Feng, XR Borschel, RH Nikolich, MP Feng, J Li, YS Hoover, DL AF Ding, Xuan Z. Feng, Xiao R. Borschel, Richard H. Nikolich, Mikeljon P. Feng, Jie Li, Yan S. Hoover, David L. TI HSP-70 mitigates LPS/SKI-induced cell damage by increasing sphingosine kinase 1 (SK1) SO PROSTAGLANDINS & OTHER LIPID MEDIATORS LA English DT Article DE HSP-70; Stable gene-transfected cells; E. coli; LPS; Sphingosine kinase; Sphingosine-1-phosphate; Ceramide Cellular protection; Programmed cell death ID EPIDERMOID A-431 CELLS; HEAT-SHOCK PROTEINS; RNA INTERFERENCE; NITRIC-OXIDE; APOPTOSIS; MACROPHAGES; EXPRESSION; SPHINGOSINE-1-PHOSPHATE; CERAMIDE; DEATH AB Heat shock proteins (HSPs) are potent protectors of cellular integrity against environmental stresses, including toxic microbial products. To investigate the mechanism of HSP-70 cell protection against bacterial lipopolysaccharide (LPS), we established a stable HSP-70 gene-transfected RAW 264.7 murine macrophage model of LPS-induced cell death. Bacterial LPS increases the activity of sphingosine kinase 1 (SK1), which catalyzes formation of sphingosine-1-phosphate (S1p). S1P functions as a critical signal for initiation and maintenance of diverse aspects of immune cell activation and function. When mouse macrophages were incubated with Escherichia coli LPS (1 mu g/ml) and sphingosine kinase inhibitor (SK1, 5 mu M), 90% of cells died. Neither LPS nor SKI alone at these doses damaged the cells. The LPS/SK1-nduced cell death was partially reversed by overexpression of HSP-70 in gene-transfected macrophages. The specificity of HSP-70 in this reversal was demonstrated by transfection of HSP-70-specific siRNA. Down-regulation of HSP-70 expression after transfection of siRNA specific for HSP-70 was associated with increased LPS/SK1-induced cell damage. Overexpression of human or murine HSP-70 (HSPA1A and Hspal a, respectively) increased both cellular SK1 mRNA and protein levels. Cellular heat shock also increased SK1 protein. These studies confirm the importance of SK1 as a protective moiety in LPS-incluced cell injury and demonstrate that HSP-70-mediated protection from cells treated with LPS/SK1 is accompanied by upregulating expression of SK1. HSP-70-mediated increases in SK1 and consequent increased levels of S1P may also play a role in protection of cells from other processes that lead to programmed cell death. Published by Elsevier Inc. C1 [Ding, Xuan Z.; Feng, Xiao R.; Borschel, Richard H.; Nikolich, Mikeljon P.; Feng, Jie; Li, Yan S.; Hoover, David L.] Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. RP Ding, XZ (reprint author), Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. EM tom.ding@amedd.army.mil RI Nikolich, Mikeljon/B-2868-2011; feng, xiaorong/G-4811-2010 OI feng, xiaorong/0000-0001-8410-3020 FU DOD/DTRA [2.10027_06_WR_B] FX This work was funded by DOD/DTRA, 2.10027_06_WR_B. The views presented in this paper are those of the authors; no endorsement by the Department of the Army or the Department of Defense has been given or should be inferred. The authors would like to acknowledge Ms. Lynnette Young for excellent technical assistance. NR 30 TC 8 Z9 8 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1098-8823 J9 PROSTAG OTH LIPID M JI Prostaglandins Other Lipid Mediat. PD JUN PY 2010 VL 92 IS 1-4 BP 1 EP 7 DI 10.1016/j.prostaglandins.2009.12.006 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 614AP UT WOS:000279027600001 PM 20123033 ER PT J AU Santiago, PN Wilk, JE Milliken, CS Castro, CA Engel, CC Hoge, CW AF Santiago, Patcho N. Wilk, Joshua E. Milliken, Charles S. Castro, Carl A. Engel, Charles C. Hoge, Charles W. TI Screening for Alcohol Misuse and Alcohol-Related Behaviors Among Combat Veterans SO PSYCHIATRIC SERVICES LA English DT Article ID TRAUMATIC BRAIN-INJURY; MENTAL-HEALTH PROBLEMS; PRIMARY-CARE; MILITARY; IRAQ; DISORDERS; PERSONNEL; PTSD; DUTY AB Objective: The U.S. military conducts health screenings of service members three to six months after they return from combat deployments. This population health program includes a modified version of the Two-Item Conjoint Screen (TICS), which is widely used in primary care to screen for alcohol misuse. Rates of referral in the military for alcohol treatment are very low, and the utility of these screening questions in predicting serious alcohol-related behaviors is unknown. Methods: Anonymous surveys were collected from 6,527 U. S. Army soldiers who were screened three to four months after returning from deployment to Iraq. Positive responses on the TICS alcohol screen were correlated with alcohol-related behaviors. Odds ratios (ORs) were calculated using logistic regression, after adjusting for gender, rank, race, and military component (active or reserve). Results: Twenty-seven percent of soldiers screened positive for alcohol misuse. Compared with soldiers who screened negative, those who screened positive were more likely to have recently engaged in the following behaviors: drinking and driving (OR=4.99, 95% confidence interval [CI]=4.31-5.76), riding with a driver who had been drinking (OR=5.87, CI=4.99-6.91), reporting late or missing work because of a hangover (OR=9.24, CI=6.73-12.68), using illicit drugs (OR=4.97, CI=3.68-6.71), being referred to alcohol rehabilitation (OR=7.15, CI=4.84-10.58), and being convicted of driving under the influence (OR=4.84, CI=3.04-7.67). Conclusions: Positive responses to a two-item alcohol screening tool were strongly associated with serious alcohol-related behaviors. This study highlights the need to improve screening and access to care for alcohol-related problems among service members returning from combat deployments. (Psychiatric Services 61:575-581, 2010) C1 [Santiago, Patcho N.; Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Wilk, Joshua E.; Milliken, Charles S.; Castro, Carl A.; Hoge, Charles W.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. RP Santiago, PN (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM psantiago@usuhs.mil NR 21 TC 37 Z9 37 U1 3 U2 7 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD JUN PY 2010 VL 61 IS 6 BP 575 EP 581 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 602UT UT WOS:000278165100008 PM 20513680 ER PT J AU Kim, PY Thomas, JL Wilk, JE Castro, CA Hoge, CW AF Kim, Paul Y. Thomas, Jeffrey L. Wilk, Joshua E. Castro, Carl A. Hoge, Charles W. TI Stigma, Barriers to Care, and Use of Mental Health Services Among Active Duty and National Guard Soldiers After Combat SO PSYCHIATRIC SERVICES LA English DT Article ID POSTTRAUMATIC-STRESS; PTSD CHECKLIST; MILITARY; IRAQ; AFGHANISTAN; DEPLOYMENT AB Objective: This study examined rates of utilization of mental health care among active duty and National Guard soldiers with mental health problems three and 12 months after they returned from combat in Iraq. Stigma and barriers to care were also reported for each component (active duty and National Guard). Methods: Cross-sectional, anonymous surveys were administered to 10,386 soldiers across both time points and components. Mean scores from 11 items measuring stigma and barriers to care were computed. Service utilization was assessed by asking soldiers whether they had received services for a mental health problem from a mental health professional, a medical doctor, or the Department of Veterans Affairs in the past month. Risk of mental problems was measured using the Patient Health Questionnaire, the PTSD Checklist, and items asking about aggressive behaviors and "stress, emotional, alcohol, or family" problems within the past month. Results: A higher proportion of active duty soldiers than National Guard soldiers reported at least one type of mental health problem at both three months (45% versus 33%) and 12 months (44% versus 35%) postdeployment. Among soldiers with mental health problems, National Guard soldiers reported significantly higher rates of mental health care utilization 12 months after deployment, compared with active duty soldiers (27% versus 13%). Mean stigma scores were higher among active duty soldiers than among National Guard soldiers. Conclusions: Active duty soldiers with a mental health problem had significantly lower rates of service utilization than National Guard soldiers and significantly higher endorsements of stigma. Current and future efforts to improve care for veterans should work toward reducing the stigma of receiving mental health care. (Psychiatric Services 61:572-588, 2010) C1 [Kim, Paul Y.; Thomas, Jeffrey L.; Wilk, Joshua E.; Hoge, Charles W.] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA. [Castro, Carl A.] USA, Med Res & Mat Command, Frederick, MD USA. RP Kim, PY (reprint author), Walter Reed Army Inst Res, Dept Mil Psychiat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM paul.kim@amedd.army.mil FU U.S. Army FX This study was supported by the Military Operational Medicine Research Program, U.S. Army Medical Research and Materiel Command and by core departmental funding. The authors thank Paul Bliese, Ph.D., for helpful comments on draft versions of this article as well as the Land Combat Study team for their support with the data collection. Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the Department of the Army or the Department of Defense. NR 24 TC 106 Z9 107 U1 2 U2 18 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1075-2730 J9 PSYCHIAT SERV JI Psychiatr. Serv. PD JUN PY 2010 VL 61 IS 6 BP 582 EP 588 PG 7 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 602UT UT WOS:000278165100009 PM 20513681 ER PT J AU Kubany, ES Ralston, TC Hill, EE AF Kubany, Edward S. Ralston, Tyler C. Hill, Elizabeth E. TI Intense Fear, Helplessness, "and" Horror? An Empirical Investigation of DSM-IV PTSD Criterion A2 SO PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY LA English DT Article DE PTSD; Criterion A2; diagnosis; trauma response ID POSTTRAUMATIC-STRESS-DISORDER; VIOLENT CRIME; VALIDATION; INVENTORY; VICTIMS AB In the Diagnostic and Statistical Manual of Mental Disorders (4th ed., DSM-IV; American Psychiatric Association [APA]), an experiential response was added to the posttraumatic stress disorder (PTSD) traumatic stressor criterion (Criterion A). In addition to witnessing or experiencing an event involving serious threat to one's life or physical integrity (Criterion A1), a traumatic stressor must also evoke an intensely negative emotional response (Criterion A2), operationalized as "intense fear, helplessness, or horror" (emphasis added, p. 428). There has been some question about, but little empirical investigation of, the PTSD predictive value of Criterion A2. Toward this end, a study was conducted to examine differential rates of PTSD among individuals who met Criterion A2 by reporting 1, 2, or all 3 A2 responses. Participants included 205 military personnel, military retirees, and military family members who were receiving services from 4 treatment programs at an army medical center. Forty-three percent of individuals who reported all 3 A2 responses met diagnostic criteria for PTSD; however, only 9% of individuals who reported fewer than 3 A2 responses met criteria for PTSD. The results suggest that the definition of PTSD Criterion A2 may be too broad. A revision or refinement of Criterion A2 in the next edition of the DSM may be indicated. C1 [Kubany, Edward S.; Ralston, Tyler C.] Natl Ctr PTSD, Dept Vet Affairs, Honolulu, HI USA. [Hill, Elizabeth E.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kubany, ES (reprint author), Behav Therapy Clin, 4211 Waialae Ave,Suite 206A, Honolulu, HI 96816 USA. EM kubany@hawaii.rr.com NR 20 TC 8 Z9 8 U1 1 U2 6 PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA SN 1942-9681 J9 PSYCHOL TRAUMA-US JI Psychol. Trauma PD JUN PY 2010 VL 2 IS 2 BP 77 EP 82 DI 10.1037/a0019185 PG 6 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 742CD UT WOS:000288914800002 ER PT J AU Parnell, GS Smith, CM AF Parnell, Gregory S. Smith, Christopher M. TI Response to Parnell, Smith, and Moxley, Intelligent Adversary Risk Analysis: A Bioterrorism Risk Management Model, Risk Analysis, Vol. 30, No. 1, 2010 SO RISK ANALYSIS LA English DT Article C1 [Parnell, Gregory S.] US Mil Acad, Official Mail & Distribut Ctr, Dept Syst Engn, MADN SE, West Point, NY 10996 USA. [Smith, Christopher M.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Parnell, GS (reprint author), US Mil Acad, Official Mail & Distribut Ctr, Dept Syst Engn, MADN SE, 646 Swift Rd, West Point, NY 10996 USA. EM gparnell@innovativedecisions.com NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD JUN PY 2010 VL 30 IS 6 BP 876 EP 876 DI 10.1111/j.1539-6924.2010.01441.x PG 1 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA 612VA UT WOS:000278931200003 ER PT J AU Dubick, M Baer, L Barr, J Wu, X Grubbs, D Pidcoke, H Wade, C AF Dubick, M. Baer, L. Barr, J. Wu, X. Grubbs, D. Pidcoke, H. Wade, C. TI ANTIOXIDANT STATUS IN TISSUES FROM RATS SUBJECTED TO THERMAL INJURY, HINDLIMB UPLOADING AND INSULIN THERAPY SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Dubick, M.; Baer, L.; Barr, J.; Wu, X.; Grubbs, D.; Pidcoke, H.; Wade, C.] US Army Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 19 EP 19 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000062 ER PT J AU Burns, J Baer, L Dubick, M Wade, C AF Burns, J. Baer, L. Dubick, M. Wade, C. TI CONTROLLED 60% HEMORRHAGE RESUSCITATION WITH SMALL VOLUME P188 IN MINIATURE SWINE SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Burns, J.; Baer, L.; Dubick, M.; Wade, C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 37 EP 38 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000125 ER PT J AU Rubal, B Neal, C Sartin, C Dubick, M DeLorenzo, R AF Rubal, B. Neal, C. Sartin, C. Dubick, M. DeLorenzo, R. TI THE POTENTIAL FOR IMPROVED INTRAOSSEOUS FLOW AT LOW INFUSION PRESSURES SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Rubal, B.; Neal, C.; Sartin, C.; Dubick, M.; DeLorenzo, R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 39 EP 39 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000130 ER PT J AU Sondeen, J Prince, D Kheirabadi, B Wade, C Polykratis, A DeGuzman, R Dubick, M AF Sondeen, J. Prince, D. Kheirabadi, B. Wade, C. Polykratis, A. DeGuzman, R. Dubick, M. TI INITIAL RESUSCITATION WITH PLASMA AND BLOOD COMPONENTS REDUCED BLEEDING COMPARED TO HEXTEND IN ANESTHETIZED SWINE WITH UNCONTROLLED SPLENIC HEMORRHAGE SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Sondeen, J.; Prince, D.; Kheirabadi, B.; Wade, C.; Polykratis, A.; DeGuzman, R.; Dubick, M.] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 39 EP 39 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000129 ER PT J AU Baer, LA Mccue, R Hsu, O Wade, CE AF Baer, L. A. McCue, R. Hsu, O. Wade, C. E. TI EFFECTS OF DISUSE AND CONTROLLED HEMORRHAGE ON LIVER FUNCTION IN RATS SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Baer, L. A.; McCue, R.; Hsu, O.; Wade, C. E.] USA, Inst Surg Res, San Antonio, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 40 EP 41 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000134 ER PT J AU Batchinsky, A Necsoiu, C Jordan, B Burns, J Baer, L Wade, C Cancio, L AF Batchinsky, A. Necsoiu, C. Jordan, B. Burns, J. Baer, L. Wade, C. Cancio, L. TI EFFECTS OF SELECTIVE AUTONOMIC BLOCKADE ON HEART RATE COMPLEXITY AND SURVIVAL TIME DURING LETHAL HEMORRHAGIC SHOCK SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Batchinsky, A.; Necsoiu, C.; Jordan, B.; Burns, J.; Baer, L.; Wade, C.; Cancio, L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RI Necsoiu, Corina/A-6255-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 42 EP 42 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000139 ER PT J AU Martini, W Jordan, B Chung, K Colvin, S Terrazas, I Cortez, D Miranda, N Dubick, M AF Martini, W. Jordan, B. Chung, K. Colvin, S. Terrazas, I. Cortez, D. Miranda, N. Dubick, M. TI LONG-TERM EFFECTS OF HEMORRHAGIC SHOCK ON COAGULATION IN PIGS SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Martini, W.; Jordan, B.; Chung, K.; Colvin, S.; Terrazas, I.; Cortez, D.; Miranda, N.; Dubick, M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 42 EP 42 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000138 ER PT J AU Chunng, KK Shelhamer, MC Aden, JK Merrill, GA Schwacha, MG Cancio, LC Renz, EM Wade, CE Blackbourne, LH AF Chunng, K. K. Shelhamer, M. C. Aden, J. K. Merrill, G. A. Schwacha, M. G. Cancio, L. C. Renz, E. M. Wade, C. E. Blackbourne, L. H. TI INFLAMMATORY RESPONSE TO HIGH FREQUENCY PERCUSSIVE VENTILATION SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Chunng, K. K.; Shelhamer, M. C.; Aden, J. K.; Merrill, G. A.; Schwacha, M. G.; Cancio, L. C.; Renz, E. M.; Wade, C. E.; Blackbourne, L. H.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 57 EP 57 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000186 ER PT J AU Rayburn, D Byzek, S Gist, I Atkins, J AF Rayburn, D. Byzek, S. Gist, I. Atkins, J. TI EFFECT OF CHANGES IN DIETARY NITRITE ON VENTILATION SO SHOCK LA English DT Meeting Abstract CT 33rd Annual Conference on Shock CY JUN 12-15, 2010 CL Portland, OR SP Shock Soc C1 [Rayburn, D.; Byzek, S.; Gist, I.; Atkins, J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 SU 1 BP 65 EP 65 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IC UT WOS:000277828000212 ER PT J AU Ryan, KL Rickards, CA Ludwig, DA Convertino, VA AF Ryan, Kathy L. Rickards, Caroline A. Ludwig, David A. Convertino, Victor A. TI TRACKING CENTRAL HYPOVOLEMIA WITH ECG IN HUMANS: CAUTIONS FOR THE USE OF HEART PERIOD VARIABILITY IN PATIENT MONITORING SO SHOCK LA English DT Article DE Heart rate variability; hemorrhage; trauma; lower body negative pressure ID BODY NEGATIVE-PRESSURE; COMBAT CASUALTY CARE; TRAUMA PATIENTS; HEMORRHAGIC-SHOCK; CARDIOVASCULAR VARIABILITY; ARTERIAL-PRESSURE; POINCARE PLOT; REMOTE TRIAGE; STROKE VOLUME; COMPLEXITY AB Heart period variability (HPV) metrics have been suggested for use in medical monitoring of trauma patients. This study sought to ascertain the use of various HPV metrics in tracking central blood volume during simulated hemorrhage in individual humans. One hundred one healthy nonsmoking volunteers (58 men, 43 women) were instrumented for continuous measurement of electrocardiogram and beat-by-beat finger arterial blood pressure. Stroke volume (SV) was estimated from the arterial pulse wave and used to reflect central blood volume. Progressive lower body negative pressure (LBNP) was applied in 5-min stages until the onset of impending hemodynamic decompensation (systolic blood pressure <70 mmHg and/or presyncopal symptoms). HPV was assessed with analysis of R-to-R intervals using both linear (time and frequency domains) and nonlinear (e. g., complexity, fractality) methods. Application of increasing LBNP caused progressive reductions of SV, whereas arterial pressures changed only minimally and late. Group LBNP stage means for each HPV metric changed progressively and were strongly correlated with the mean decrease in SV (vertical bar r vertical bar >= 0.87). To ascertain the utility of the HPV metrics to track individual responses to central hypovolemia, the difference scores for each HPV metric were correlated at each successive LBNP level, with percentage change in SV at the subject level. This cross-correlation of difference scores revealed that none of the HPV metrics showed strong and consistent correlations (vertical bar r vertical bar <= 0.49) with percentage change in SV across successive LBNP levels. Although aggregate group mean values for HPV metrics are well correlated with SV changes during central hypovolemia, these metrics are less reliable when tracking individual reductions in central volume during LBNP. HPV metrics, therefore, may not be useful in monitoring hemorrhagic injuries in individual patients. C1 [Ryan, Kathy L.; Rickards, Caroline A.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX USA. [Ludwig, David A.] Univ Miami, Miller Sch Med, Div Clin Res, Dept Pediat, Miami, FL 33136 USA. RP Ryan, KL (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM kathy.ryan@amedd.army.mil FU US Army Medical Research; Materiel Command Combat Casualty Care Research Program, Ft Detrick, Md FX This study was supported by the US Army Medical Research and Materiel Command Combat Casualty Care Research Program, Ft Detrick, Md. NR 56 TC 28 Z9 28 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2010 VL 33 IS 6 BP 583 EP 589 DI 10.1097/SHK.0b013e3181cd8cbe PG 7 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 598IK UT WOS:000277828800005 PM 19997052 ER PT J AU Collen, J Holley, A Lettieri, C Shah, A Roop, S AF Collen, Jacob Holley, Aaron Lettieri, Christopher Shah, Anita Roop, Stuart TI The impact of split-night versus traditional sleep studies on CPAP compliance SO SLEEP AND BREATHING LA English DT Article DE Obstructive sleep apnea; Continuous positive airway pressure; Compliance; Adherence; Polysomnography; Split-night polysomnography ID POSITIVE AIRWAY PRESSURE; BLOOD-PRESSURE; APNEA; POLYSOMNOGRAPHY; THERAPY; TITRATION; DIAGNOSIS; APNEA/HYPOPNEA; ADHERENCE; PROTOCOL AB Split-night polysomnography allows for the diagnosis of obstructive sleep apnea and titration of continuous positive airway pressure in a single study. However, there is concern that split-night studies do not provide sufficient time for optimal continuous positive airway pressure (CPAP) titration, which may lead to a poor initial experience with CPAP and potentially, worse adherence. Our goal was to determine whether CPAP use, after a split-night examination, is comparable to the use following separate diagnostic and titration studies. We included consecutive patients presenting for follow-up 4-6 weeks after initiating CPAP therapy. Objective measures of CPAP use were recorded, and adherence to therapy was analyzed based on the initial method of diagnosis and titration-split-night versus dual-night study. A total of 400 patients (78% male, mean age 47 +/- 8 years) were included. Among the patients, 267 and 133 underwent split- and dual-night studies, respectively. The groups were similar at baseline; however, the average apnea-hypopnea index was significantly higher in the split-night group. Mean number of days between diagnosis and titration in the dual-night group was 80.5 days. There was no difference in therapeutic adherence between groups as measured by percentage of nights used (78.7% vs 77.5%; p = 0.42), hours per night used (3.9 vs 3.9; p = 0.95), or percentage of patients using continuous positive airway pressure for > 4 hours per night for > 70% of nights (52.9% vs 51.8%; p = 0.81). There was no difference in use after adjusting for severity of disease. Split-night polysomnography does not adversely affect short-term continuous positive airway pressure adherence in patients with obstructive sleep apnea. C1 [Collen, Jacob] Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. [Holley, Aaron; Lettieri, Christopher; Shah, Anita; Roop, Stuart] Walter Reed Army Med Ctr, Dept Pulm Crit Care & Sleep Med, Washington, DC 20307 USA. RP Collen, J (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. EM jacob.collen@amedd.army.mil; aaron.b.holley@amedd.army.mil; christopher.lettieri@amedd.army.mil; anita.shah@amedd.army.mil; stuart.roop@amedd.army.mil NR 30 TC 6 Z9 7 U1 0 U2 0 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 J9 SLEEP BREATH JI Sleep Breath. PD JUN PY 2010 VL 14 IS 2 BP 93 EP 99 DI 10.1007/s11325-009-0294-y PG 7 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA 621SY UT WOS:000279605400002 PM 19714379 ER PT J AU Lee, I Choi, KK Gorsich, D AF Lee, Ikjin Choi, K. K. Gorsich, David TI System reliability-based design optimization using the MPP-based dimension reduction method SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION LA English DT Article DE MPP-based dimension reduction method (DRM); System inverse reliability analysis; First-order reliability method (FORM); Second-order reliability method (SORM) ID PERFORMANCE-MEASURE APPROACH; STRUCTURAL SYSTEMS; PROBABILITY AB The system probability of failure calculation of the series system entails multi-dimensional integration, which is very difficult and numerically expensive. To resolve the computational burden, the narrow bound method, which accounts for the component failures and joint failures between two failure modes, has been widely used. For the analytic calculation of the component probability of failure, this paper proposes to use the most probable point (MPP)-based dimension reduction method (DRM). For the joint probability of failure calculation, three cases are considered based on the convexity or concavity of the performance functions. Design sensitivity analysis for the system reliability-based design optimization (RBDO), which is the major contribution of this paper, is carried out as well. Based on the results of numerical examples, the system probability of failure and its sensitivity calculation show very good agreement with the results obtained by Monte Carlo simulation (MCS) and the finite difference method (FDM). C1 [Lee, Ikjin; Choi, K. K.; Gorsich, David] Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. [Gorsich, David] US Army, RDECOM TARDEC, Warren, MI 48397 USA. RP Choi, KK (reprint author), Univ Iowa, Coll Engn, Dept Mech & Ind Engn, Iowa City, IA 52242 USA. EM ilee@engineering.uiowa.edu; kkchoi@engineering.uiowa.edu; david.gorsich@us.army.mil RI Lee, IkJin/I-4722-2013; Choi, Kyung/B-1512-2008 OI Choi, Kyung/0000-0003-2384-6220 FU U.S. Army TARDEC; ARO [W911NF-09-1-0250] FX Research is jointly supported by the Automotive Research Center, which is sponsored by the U.S. Army TARDEC, and ARO Project W911NF-09-1-0250. These supports are greatly appreciated. NR 44 TC 21 Z9 21 U1 1 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1615-147X J9 STRUCT MULTIDISCIP O JI Struct. Multidiscip. Optim. PD JUN PY 2010 VL 41 IS 6 BP 823 EP 839 DI 10.1007/s00158-009-0459-0 PG 17 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary; Mechanics SC Computer Science; Engineering; Mechanics GA 584SH UT WOS:000276772400001 ER PT J AU Steigman, JD AF Steigman, Jonathan D. TI An Inca Account of the Conquest of Peru. SO STUDIES IN AMERICAN INDIAN LITERATURES LA English DT Book Review C1 [Steigman, Jonathan D.] US Mil Acad, Dept Foreign Languages, West Point, NY 10996 USA. RP Steigman, JD (reprint author), US Mil Acad, Dept Foreign Languages, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV NEBRASKA PRESS PI LINCOLN PA 1111 LINCOLN MALL, LINCOLN, NE 68588-0630 USA SN 0730-3238 J9 STUD AM INDIAN LIT JI Stud. Am. Indian Lit. PD SUM PY 2010 VL 22 IS 2 BP 86 EP 89 PG 4 WC Literature, American SC Literature GA 644JA UT WOS:000281370100007 ER PT J AU Henry, LR Helou, LB Solomon, NP Howard, RS Gurevich-Uvena, J Coppit, G Stojadinovic, A AF Henry, Leonard R. Helou, Leah B. Solomon, Nancy Pearl Howard, Robin S. Gurevich-Uvena, Joyce Coppit, George Stojadinovic, Alexander TI Functional voice outcomes after thyroidectomy: An assessment of the Dsyphonia Severity Index (DSI) after thyroidectomy SO SURGERY LA English DT Article ID SUPERIOR LARYNGEAL NERVE; DYSPHONIA SEVERITY; PERCEPTUAL EVALUATION; EXTERNAL BRANCH; SURGERY; IDENTIFICATION; INJURY; GENDER; ADULTS; USERS AB Background. The Dysphonia Severity Index (DSI) is an objective multiparametric acoustic calculation of vocal function; however its changes after thyroidectomy have not yet been described. Methods. Patient-reported symptoms, as well as auditory perceptual, acoustic, and videolaryngostroboscopic (VLS) data, were collected prospectively before and after thyroidectomy. Voice outcomes (normal versus negative voice outcome [NVO]) at 6 months alter thyroidectomy were based on a combination of voice symptoms and objective findings. The DSI was assessed over the pen-operative course, and differences were determined with Wilcoxon signed rank tests. The DSI was compared between study groups (normal versus NVO) using t tests, analyses of variance (ANOVAs), or rank sum tests as appropriate. The predictive value of DSI for long-term voice dysfunction was assessed by an area under the receiver operating characteristics curve analysis. Correlations between DSI and Consensus Auditory Perceptual Ratings of Voice (CAPE-V) and the patient reported Voice Handicap Index (MD were determined with Pearson's correlation coefficients. Results. In all, 62 patients were evaluated before, 1-4 weeks after; and 6 months after thyroidectomy. Eight (13%) patients were diagnosed with NVO at 6 months. The DSI was different postoperatively between NVO and normal voice (P = .005, repeated measures [RM]-ANOVA), with the NVO group demonstrating a lesser DSI value and greater change from pre-operative assessment at the first postoperative visit when compared with the normal group (P < .006 each): The DSI differed significantly for pre-operative and 6-month assessments according to sex, smoking status, and age. Short-term postoperative DSI (area under the curve [AUG] = 0.795) and DSI change from baseline to 1-4 weeks (AUC = 0.835) were highly predictive of 6-month NVO. DSI measurements over the post-thyroidectomy course were correlated poorly to moderately (maximum r = -0.62) with CAPE-V and VHI assessments for the same time points. Conclusion. The DSI is decreased in the early post-thyroidectomy period, mostly in persons who were ultimately found to have a long-term NVO. Early postoperative DSI and change of DSI from baseline at 1-4 weeks postoperation predict long-term post-thyroidectomy voice dysfunction. The modest correlations between the DSI and other vocal assessments point to the utility of DSI as an independent predictor of voice dysfunction after thyroidectomy, which can select patients who may benefit from voice therapy. (Surgery 2010;147:861-70.) C1 [Henry, Leonard R.] Uniformed Serv Univ Hlth Sci, Dept Surg, Natl Naval Med Ctr, Bethesda, MD 20889 USA. [Henry, Leonard R.; Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. [Coppit, George] Walter Reed Army Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. [Solomon, Nancy Pearl; Gurevich-Uvena, Joyce] Army Audiol & Speech Ctr, Washington, DC USA. [Howard, Robin S.] Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. RP Henry, LR (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Natl Naval Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM leonard.henry@med.navy.mil NR 32 TC 22 Z9 23 U1 1 U2 4 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0039-6060 J9 SURGERY JI Surgery PD JUN PY 2010 VL 147 IS 6 BP 861 EP 870 DI 10.1016/j.surg.2009.11.017 PG 10 WC Surgery SC Surgery GA 607UM UT WOS:000278532300016 PM 20096434 ER PT J AU Satava, RM AF Satava, Richard M. TI Emerging Trends that Herald the Future of Surgical Simulation SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Surgical simulation; Simulation science; Surgical education; Skills curricula ID VIRTUAL-REALITY AB For the first time in over 100 years, there is a revolution in surgical education. One of the most important core technologies generating this revolution is simulation science, which includes not only the technology of simulators but new curricula, objective assessment methods, and criterion-based requirements. By reviewing the current status of simulation and making comparisons with the emerging technologies, an analysis of the gaps can demonstrate the necessary direction for the future. C1 [Satava, Richard M.] Univ Washington, Dept Surg, Med Ctr, Seattle, WA 98195 USA. [Satava, Richard M.] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Satava, RM (reprint author), Univ Washington, Dept Surg, Med Ctr, 1959 Pacific St NE, Seattle, WA 98195 USA. EM rsatava@u.washington.edu NR 9 TC 30 Z9 31 U1 2 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD JUN PY 2010 VL 90 IS 3 BP 623 EP + DI 10.1016/j.suc.2010.02.002 PG 12 WC Surgery SC Surgery GA 613GI UT WOS:000278967000014 PM 20497831 ER PT J AU Thomas, JE Munir, JA McIntyre, PZ Ferguson, MA AF Thomas, John E. Munir, Jamalah A. McIntyre, Peter Z. Ferguson, Michael A. TI Lack of Evidence that p-Synephrine is Responsible for STEMI Reply SO TEXAS HEART INSTITUTE JOURNAL LA English DT Letter ID DIETARY-SUPPLEMENT C1 [Thomas, John E.; Munir, Jamalah A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [McIntyre, Peter Z.; Ferguson, Michael A.] Natl Naval Med Ctr, Bethesda, MD USA. RP Thomas, JE (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU TEXAS HEART INST PI HOUSTON PA PO BOX 20345, HOUSTON, TX 77225-0345 USA SN 0730-2347 J9 TEX HEART I J JI Tex. Heart Inst. J. PD JUN PY 2010 VL 37 IS 3 BP 383 EP 384 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 607PI UT WOS:000278517600036 ER PT J AU Jensen, ET AF Jensen, Eric Talbot TI Cyber Warfare and Precautions Against the Effects of Attacks SO TEXAS LAW REVIEW LA English DT Article ID STATES AB Ninety-eight percent of all U.S. government communications travel over civilian-owned-and-operated networks. Additionally, the government relies almost completely on civilian providers for computer software and hardware products, services, and maintenance. This near-complete intermixing of civilian and military computer infrastructure makes many of those civilian objects and providers legitimate targets under the law of armed conflict. Other civilian networks, services, and communications may suffer collateral damage from legitimate attacks on government targets. To protect those civilian objects and providers from the effects of attacks, the law of armed conflict requires a state to segregate its military assets from the civilian population and civilian objects to the maximum extent feasible. Where segregation is not feasible, the government must protect the civilian entities and communications from the effects of attacks. The current integration of U.S. government assets with civilian systems makes segregation impossible and therefore creates a responsibility for the United States to protect those civilian networks, services, and communications. The US. government is already taking some steps in that direction, as illustrated by a number of plans and policies initiated over the past decade. However, the current actions do not go far enough. This Article identifies six vital actions the government must take to comply with the law of armed conflict and to ensure not only the survivability of military communication capabilities during times of armed conflict, but also the protection of the civilian populace and civilian objects. C1 [Jensen, Eric Talbot] USA, Off Judge Advocate Gen, Int Law Branch, Washington, DC USA. RP Jensen, ET (reprint author), Fordham Law Sch, New York, NY USA. NR 99 TC 8 Z9 8 U1 3 U2 19 PU TEXAS LAW REVIEW PUBL INC PI AUSTIN PA 727 E 26TH ST, AUSTIN, TX 78705 USA SN 0040-4411 J9 TEX LAW REV JI Tex. Law Rev. PD JUN PY 2010 VL 88 IS 7 BP 1533 EP 1569 PG 37 WC Law SC Government & Law GA 632QY UT WOS:000280443400005 ER PT J AU Perkins, MW Pierre, Z Rezk, P Sabnekar, P Kabra, K Chanda, S Oguntayo, S Sciuto, AM Doctor, BP Nambiar, MP AF Perkins, Michael W. Pierre, Zdenka Rezk, Peter Sabnekar, Praveena Kabra, Kareem Chanda, Soma Oguntayo, Samuel Sciuto, Alfred M. Doctor, Bhupendra P. Nambiar, Madhusoodana P. TI Acute respiratory toxicity following inhalation exposure to soman in guinea pigs SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE Organophosphates; Chemical warfare; Respiratory toxicity; Cholinesterases; Neuroprotection; Inhalation exposure; Central nervous system; Nerve agents ID NERVE AGENT-VX; CHEMICAL WEAPONS; HUMAN ACETYLCHOLINESTERASE; ORGANOPHOSPHORUS COMPOUNDS; INDUCED NEUROPATHOLOGY; TISSUE CHOLINESTERASE; TOKYO SUBWAY; SARIN; PROTECTION; EFFICACY AB Respiratory toxicity and lung injury following inhalation exposure to chemical warfare nerve agent soman was examined in guinea pigs without therapeutics to improve survival. A microinstillation inhalation exposure technique that aerosolizes the agent in the trachea was used to administer soman to anesthetized age and weight matched male guinea pigs. Animals were exposed to 280, 561, 841, and 1121 mg/m(3) concentrations of soman for 4 min. Survival data showed that all saline controls and animals exposed to 280 and 561 mg/m(3) soman survived, while animals exposed to 841, and 1121 mg/m(3) resulted in 38% and 13% survival, respectively. The microinstillation inhalation exposure LCt(50) for soman determined by probit analysis was 827.2 mg/m(3). A majority of the animals that died at 1121 mg/m(3) developed seizures and died within 15-30 min post-exposure. There was a dose-dependent decrease in pulse rate and blood oxygen saturation of animals exposed to soman at 5-6.5 min post-exposure. Body weight loss increased with the dose of soman exposure. Bronchoalveolar lavage (BAL) fluid and blood acetylcholinesterase and butyrylcholinesterase activity was inhibited dose-dependently in soman treated groups at 24 h. BAL cells showed a dose-dependent increase in cell death and total cell counts following soman exposure. Edema by wet/dry weight ratio of the accessory lung lobe and trachea was increased slightly in soman exposed animals. An increase in total bronchoalveolar lavage fluid protein was observed in soman exposed animals at all doses. Differential cell counts of BAL and blood showed an increase in total lymphocyte counts and percentage of neutrophils. These results indicate that microinstillation inhalation exposure to soman causes respiratory toxicity and acute lung injury in guinea pigs. Published by Elsevier Inc. C1 [Kabra, Kareem; Chanda, Soma; Oguntayo, Samuel; Doctor, Bhupendra P.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Brain Dysfunct & Blast Injury Div, Silver Spring, MD 20910 USA. [Perkins, Michael W.; Pierre, Zdenka; Rezk, Peter; Sabnekar, Praveena; Sciuto, Alfred M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Brain Dysfunct & Blast Injury Div, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM madhusoodana.nambiar@us.army.mil FU Defense Threat Reduction Agency FX The project described was supported by the Defense Threat Reduction Agency. Its contents, opinions and assertions contained herein are private views of the authors are not to be construed as official or reflecting the views of the Department of the Army or the Department of Defense. NR 54 TC 12 Z9 12 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD JUN 1 PY 2010 VL 245 IS 2 BP 171 EP 178 DI 10.1016/j.taap.2010.02.016 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 601SB UT WOS:000278083100004 PM 20206646 ER PT J AU Matheu, FA McFaul, SJ AF Matheu, Frederick A. McFaul, Steve J. TI Supernates from stored red blood cells inhibit platelet aggregation SO TRANSFUSION LA English DT Article ID ACUTE LUNG INJURY; TRANSFUSION; STORAGE; COMPONENTS; RELEASE; SURGERY; PLASMA; PRIMES; LIPIDS AB BACKGROUND: Previously, we reported that red blood cells (RBCs) stored in AS-5 accumulated proinflammatory substances during storage. We observed in those studies that supernates from nonleukoreduced (NLR) RBCs reduced mean anti-CD41a-fluorescein isothiocyanate (FITC) fluorescence on platelets (PLTs), indicative of decreased expression of glycoprotein (GP)IIb/IIIa on the PLT membrane. The objective of this study was to determine if supernates from stored RBCs impaired PLT aggregation as a consequence of reduction in GPIIb/IIIa expression. STUDY DESIGN AND METHODS: Leukoreduced (LR) and NLR RBC units were prepared in AS-5 and stored at 1 to 6 degrees C for 6 weeks. Supernates from RBC samples collected every 2 weeks were mixed with freshly collected type-matched blood and incubated for 30 minutes at 37 degrees C. PLTs in each incubated blood sample were evaluated for GPIIb/IIIa expression by flow cytometry and for aggregation response to collagen by whole blood aggregometry. RESULTS: Supernates from stored NLR RBCs reduced CD41a-FITC fluorescence on PLTs by 15% to 31%. A reduction in fluorescence was induced by supernates of RBCs stored for 14 days and increased as storage time increased. Supernates from Day 42 NLR RBCs reduced the mean amplitude of PLT aggregation by 31% compared to Day 0 supernates and lengthened the time before onset of aggregation by 21%. In addition, amplitude correlated directly and lag time correlated inversely with CD41a-FITC fluorescence in all samples. Supernates from prestorage LR RBCs did not affect PLT CD41a-FITC fluorescence or aggregation response. CONCLUSIONS: Substances that decrease expression of GPIIb/IIIa and inhibit PLT aggregation accumulate in NLR RBCs. Accumulation of this material is prevented by leukoreduction. C1 [Matheu, Frederick A.; McFaul, Steve J.] Walter Reed Army Inst Res, Dept Blood Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. RP McFaul, SJ (reprint author), Walter Reed Army Inst Res, Dept Blood Res, Div Mil Casualty Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM steve.mcfaul@us.army.mil NR 26 TC 4 Z9 4 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD JUN PY 2010 VL 50 IS 6 BP 1196 EP 1202 DI 10.1111/j.1537-2995.2010.02582.x PG 7 WC Hematology SC Hematology GA 604ZH UT WOS:000278316500008 PM 20158688 ER PT J AU Roback, JD Caldwell, S Carson, J Davenport, R Drew, MJ Eder, A Fung, M Hamilton, M Hess, JR Luban, N Perkins, JG Sachais, BS Shander, A Silverman, T Snyder, E Tormey, C Waters, J Djulbegovic, B AF Roback, John D. Caldwell, Stephen Carson, Jeff Davenport, Robertson Drew, Mary Jo Eder, Anne Fung, Mark Hamilton, Marilyn Hess, John R. Luban, Naomi Perkins, Jeremy G. Sachais, Bruce S. Shander, Aryeh Silverman, Toby Snyder, Ed Tormey, Christopher Waters, John Djulbegovic, Ben TI Evidence-based practice guidelines for plasma transfusion SO TRANSFUSION LA English DT Article ID FRESH-FROZEN PLASMA; I TRAUMA CENTER; LIFE-THREATENING COAGULOPATHY; DAMAGE CONTROL HEMATOLOGY; BLOOD-PRODUCT UTILIZATION; LAST 60 YEARS; EXSANGUINATION PROTOCOL; RETROSPECTIVE ANALYSIS; LIVER-TRANSPLANTATION; MASSIVE TRANSFUSION AB BACKGROUND: There is little systematically derived evidence-based guidance to inform plasma transfusion decisions. To address this issue, the AABB commissioned the development of clinical practice guidelines to help direct appropriate transfusion of plasma. STUDY DESIGN AND METHODS: A systematic review (SR) and meta-analysis of randomized and observational studies was performed to quantify known benefits and harms of plasma transfusion in common clinical scenarios (see accompanying article). A multidisciplinary guidelines panel then used the SR and the GRADE methodology to develop evidence-based plasma transfusion guidelines as well as identify areas for future investigation. RESULTS: Based on evidence ranging primarily from moderate to very low in quality, the panel developed the following guidelines: 1) The panel suggested that plasma be transfused to patients requiring massive transfusion. However, 2) the panel could not recommend for or against transfusion of plasma at a plasma : red blood cell ratio of 1:3 or more during massive transfusion, 3) nor could the panel recommend for or against transfusion of plasma to patients undergoing surgery in the absence of massive transfusion. 4) The panel suggested that plasma be transfused in patients with warfarin therapy-related intracranial hemorrhage, 5) but could not recommend for or against transfusion of plasma to reverse warfarin anticoagulation in patients without intracranial hemorrhage. 6) The panel suggested against plasma transfusion for other selected groups of patients. CONCLUSION: We have systematically developed evidence-based guidance to inform plasma transfusion decisions in common clinical scenarios. Data from additional randomized studies will be required to establish more comprehensive and definitive guidelines for plasma transfusion. C1 [Roback, John D.] Emory Univ, Sch Med, Dept Pathol & Lab Med, Ctr Transfus & Cellular Therapies, Atlanta, GA 30322 USA. Univ Virginia, GI Hepatol, Charlottesville, VA USA. UMDNJ Robert Wood Johnson Univ Hosp, New Brunswick, NJ USA. Univ Michigan, Sch Med, Dept Pathol, Blood Bank, Ann Arbor, MI USA. Univ Michigan, Sch Med, Dept Pathol, Transfus Serv, Ann Arbor, MI USA. Amer Red Cross, Pacific NW Blood Serv Reg, Portland, OR USA. Amer Red Cross, Biomed Serv, Washington, DC 20006 USA. Univ Vermont, Burlington, VT USA. Fletcher Allen Hlth Care, Dept Pathol, Burlington, VT USA. Childrens Mercy Hosp, Kansas City, MO 64108 USA. Univ Maryland, Dept Pathol, Med Ctr, Baltimore, MD 21201 USA. Childrens Hosp, Natl Med Ctr, Washington, DC 20010 USA. Walter Reed Army Inst Res, Dept Blood Res, Silver Spring, MD USA. Univ Penn, Dept Pathol & Lab Med, Div Transfus Med, Philadelphia, PA 19104 USA. Englewood Hosp, Mt Sinai Sch Med, Dept Anesthesiol, Englewood, NJ USA. Med Ctr, Englewood, NJ USA. Yale New Haven Med Ctr, New Haven, CT 06504 USA. US FDA, Rockville, MD 20857 USA. Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA. Univ S Florida, Ctr Evidence Based Med & Hlth Outcome Res, Clin Translat Sci Inst, Tampa, FL USA. Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA. RP Roback, JD (reprint author), Emory Univ, Sch Med, Dept Pathol & Lab Med, Ctr Transfus & Cellular Therapies, Atlanta, GA 30322 USA. EM jroback@emory.edu RI Djulbegovic, Benjamin/I-3661-2012; Hess, John/K-4001-2013 OI Djulbegovic, Benjamin/0000-0003-0671-1447; Hess, John/0000-0001-8596-4420 FU AABB FX This work was completely funded by the AABB. NR 53 TC 107 Z9 112 U1 1 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD JUN PY 2010 VL 50 IS 6 BP 1227 EP 1239 DI 10.1111/j.1537-2995.2010.02632.x PG 13 WC Hematology SC Hematology GA 604ZH UT WOS:000278316500012 PM 20345562 ER PT J AU Kabeya, H Colborn, JM Bai, Y Lerdthusnee, K Richardson, JH Maruyama, S Kosoy, MY AF Kabeya, Hidenori Colborn, James M. Bai, Ying Lerdthusnee, Kriangkrai Richardson, Jason H. Maruyama, Soichi Kosoy, Michael Y. TI Detection of Bartonella tamiae DNA in Ectoparasites from Rodents in Thailand and Their Sequence Similarity with Bacterial Cultures from Thai Patients SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Bartonella tamiae; Chigger mite; Ectoparasites; Rodent; Thailand; Tick ID VINSONII SUBSP ARUPENSIS; BORRELIA-BURGDORFERI; TRANSMISSION; ENDOCARDITIS; HENSELAE; VECTOR; FLEAS; ACARI; SPP.; ELIZABETHAE AB Ectoparasites, including chigger mites (genera Leptotrombidium, Schoengastia, and Blankarrtia) and one tick (genus Haemaphysalis) collected from wild-caught rodents in Thailand, were assessed for the presence of Bartonella DNA by using a polymerase chain reaction assay targeting the 16S-23S intergenic spacer region and citrate synthase gene (gltA). Of the 41 pooled samples tested, 34 were positive for Bartonella DNA. Sequence analysis demonstrated that DNA detected in 33 chigger mite pools and one tick pool was similar to Bartonella tamiae sequences previously isolated from three patients in Thailand. This is the first report of the detection of B. tamiae DNA in chigger mites; additional field and experimental investigations are required to determine the role of chigger mites as potential vectors of B. tamiae. C1 [Kabeya, Hidenori; Colborn, James M.; Bai, Ying; Kosoy, Michael Y.] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Ft Collins, CO 80521 USA. [Kabeya, Hidenori; Maruyama, Soichi] Nihon Univ, Lab Vet Publ Hlth, Dept Vet Med, Coll Bioresource Sci, Kanagawa, Japan. [Lerdthusnee, Kriangkrai; Richardson, Jason H.] Armed Forces Res Inst Med Sci, US Army Med Component, Dept Entomol, Bangkok 10400, Thailand. RP Kosoy, MY (reprint author), Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, 3150 Rampart Rd,Foothills Res Campus, Ft Collins, CO 80521 USA. EM mck3@cdc.gov RI Richardson, Jason/A-9441-2011 NR 32 TC 20 Z9 21 U1 1 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD JUN PY 2010 VL 10 IS 5 BP 429 EP 434 DI 10.1089/vbz.2009.0124 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 613LF UT WOS:000278980100001 PM 20017718 ER PT J AU Novy, A Smouse, PE Hartman, JM Struwe, L Honig, J Miller, C Alvarez, M Bonos, S AF Novy, Ari Smouse, Peter E. Hartman, Jean Marie Struwe, Lena Honig, Josh Miller, Chris Alvarez, Melissa Bonos, Stacy TI Genetic Variation of Spartina alterniflora in the New York Metropolitan Area and Its Relevance for Marsh Restoration SO WETLANDS LA English DT Article DE Genetic diversity; Local propagules; Poaceae; Restoration genetics; Salt water marsh ID SALT-MARSH; ECOLOGICAL RESTORATION; MICROSATELLITE LOCI; SPECIES POACEAE; GULF COASTS; DIVERSITY; LOISEL; PLANT; DIFFERENTIATION; POPULATIONS AB We examined the genetic population structure of Spartina alterniflora in Jamaica Bay, Queens, NY and the surrounding area in order to assist the ongoing restoration of Jamaica Bay. AMOVA (Analysis of Molecular Variance) indicated that population differences accounted for 15% of molecular variance (I broken vertical bar (PT) = 0.15, p = 0.001). Observed heterozygosity (H(o)) ranged from 0.61 to 0.73 among populations. A Mantel test indicated a weak and non-significant correlation between pairwise I broken vertical bar (PT) and geographic distance matrices (r = 0.34, p = 0.12). A PCA revealed no obvious grouping pattern for sampled populations. Based on these data, we determined that the studied populations contained similar genetic variability to other populations in the New York vicinity and to those of the entire region. It seems likely that collection of germplasm from within the region will prove sufficient in maintaining overall genetic variation in restoration plantings. Given the small amount of genetic structure among populations within Jamaica Bay, however, it would be prudent to collect widely within the target marsh. We also recommend the practice of propagating plugs of S. alterniflora from wild seed, as opposed to using vegetative cuttings, when creating planting stock, in order to maximize genetic diversity in restored marshes. C1 [Novy, Ari; Struwe, Lena; Honig, Josh; Bonos, Stacy] Rutgers State Univ, Dept Bot & Plant Pathol, Sch Biol & Environm Sci, New Brunswick, NJ 08901 USA. [Novy, Ari; Hartman, Jean Marie] Rutgers State Univ, Dept Landscape Architecture, Sch Biol & Environm Sci, New Brunswick, NJ 08901 USA. [Smouse, Peter E.; Struwe, Lena] Rutgers State Univ, Dept Ecol Evolut & Nat Resources, Sch Biol & Environm Sci, New Brunswick, NJ 08901 USA. [Miller, Chris] USDA NRCS Plant Mat Ctr, Cape May, NJ USA. [Alvarez, Melissa] USA, Corps Engineers, New York, NY USA. RP Novy, A (reprint author), Rutgers State Univ, Dept Bot & Plant Pathol, Sch Biol & Environm Sci, Rm 273,Foran Hall, New Brunswick, NJ 08901 USA. EM arinovy@rci.rutgers.edu FU U.S. Army Corps of Engineers; U.S. Department of Agriculture Natural Resources Conservation Service (USDA NRCS); Rutgers Center for Turfgrass Science; New Jersey Agricultural Experiment Station; Rutgers University School of Environmental and Biological Sciences FX Funding for this project was provided by the U.S. Army Corps of Engineers, U.S. Department of Agriculture Natural Resources Conservation Service (USDA NRCS), Rutgers Center for Turfgrass Science, New Jersey Agricultural Experiment Station, and Rutgers University School of Environmental and Biological Sciences. Field collection was aided by Joseph Lampert, Christine Poulsen, and the USDA Plant Materials Center, Cape May, NJ. Figure 1 was drawn by Drew Siglin. We thank Dr. Rikke Bagger Jorgensen of Riso National Laboratory in Denmark and two anonymous reviewers for helpful suggestions on previous versions of the manuscript. NR 33 TC 5 Z9 5 U1 4 U2 21 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0277-5212 J9 WETLANDS JI Wetlands PD JUN PY 2010 VL 30 IS 3 BP 603 EP 608 DI 10.1007/s13157-010-0046-6 PG 6 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 609AD UT WOS:000278626200020 ER PT J AU Davis, AR Shear, DA Chen, ZY Lu, XCM Tortella, FC AF Davis, Angela R. Shear, Deborah A. Chen, Zhiyong Lu, Xi-Chun M. Tortella, Frank C. TI A comparison of two cognitive test paradigms in a penetrating brain injury model SO JOURNAL OF NEUROSCIENCE METHODS LA English DT Article DE Traumatic brain injury; Penetrating brain injury; Morris water maze; Novel object recognition ID ONE-TRIAL TEST; MEMORY; RATS; RECOGNITION; MOTOR AB A rat model of penetrating ballistic-like brain injury (PBBI) was recently established to study military-relevant severe traumatic brain injury (TBI). The purpose of this study was to conduct a side-by-side evaluation of two well-established cognitive testing paradigms: the novel object recognition (NOR) task and the Morris water maze (MWM) task. Accordingly, male Sprague-Dawley rats were subjected to PBBI and their cognitive abilities were assessed at 7 and 21 days post-PBBI. Although PBBI animals had more difficulty completing both tasks compared to sham animals, their performance on the NOR task was confounded by a high degree of within-group variability that was likely due to attention deficits produced by the injury. In contrast, PBBI produced consistent, significant spatial learning deficits in the MWM task. Overall, these results suggest that the MWM task provides a more appropriate cognitive test for the PBBI model that would be useful for testing promising neuroprotective therapeutics. Published by Elsevier B.V. C1 [Davis, Angela R.; Shear, Deborah A.; Chen, Zhiyong; Lu, Xi-Chun M.; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Davis, Angela R.] Geneva Fdn, Lakewood, WA 98499 USA. RP Shear, DA (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Angela.R.Davis@amedd.army.mil; Deborah.Shear@amedd.army.mil; Zhiyong.Chen@us.army.mil; May.Lu@us.army.mil; Frank.C.Tortella@us.army.mil RI Shear, Deborah/B-3607-2011 FU Department of the Army [W81XWH-08-2-0127] FX This work was supported by the Department of the Army, award W81XWH-08-2-0127, with The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702-5014, as the awarding and administering acquisition office. The information has been reviewed by the Walter Reed Army Institute of Research with no objection to its presentation and/or publication. The content of the information are the private views of the authors and does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. NR 15 TC 9 Z9 10 U1 3 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0270 J9 J NEUROSCI METH JI J. Neurosci. Methods PD MAY 30 PY 2010 VL 189 IS 1 BP 84 EP 87 DI 10.1016/j.jneumeth.2010.03.012 PG 4 WC Biochemical Research Methods; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA 604PL UT WOS:000278290900013 PM 20346980 ER PT J AU Chaitankar, V Ghosh, P Perkins, EJ Gong, P Deng, YP Zhang, CY AF Chaitankar, Vijender Ghosh, Preetam Perkins, Edward J. Gong, Ping Deng, Youping Zhang, Chaoyang TI A novel gene network inference algorithm using predictive minimum description length approach SO BMC SYSTEMS BIOLOGY LA English DT Article ID REGULATORY NETWORKS; INFORMATION; PRINCIPLE AB Background: Reverse engineering of gene regulatory networks using information theory models has received much attention due to its simplicity, low computational cost, and capability of inferring large networks. One of the major problems with information theory models is to determine the threshold which defines the regulatory relationships between genes. The minimum description length (MDL) principle has been implemented to overcome this problem. The description length of the MDL principle is the sum of model length and data encoding length. A user-specified fine tuning parameter is used as control mechanism between model and data encoding, but it is difficult to find the optimal parameter. In this work, we proposed a new inference algorithm which incorporated mutual information (MI), conditional mutual information (CMI) and predictive minimum description length (PMDL) principle to infer gene regulatory networks from DNA microarray data. In this algorithm, the information theoretic quantities MI and CMI determine the regulatory relationships between genes and the PMDL principle method attempts to determine the best MI threshold without the need of a user-specified fine tuning parameter. Results: The performance of the proposed algorithm was evaluated using both synthetic time series data sets and a biological time series data set for the yeast Saccharomyces cerevisiae. The benchmark quantities precision and recall were used as performance measures. The results show that the proposed algorithm produced less false edges and significantly improved the precision, as compared to the existing algorithm. For further analysis the performance of the algorithms was observed over different sizes of data. Conclusions: We have proposed a new algorithm that implements the PMDL principle for inferring gene regulatory networks from time series DNA microarray data that eliminates the need of a fine tuning parameter. The evaluation results obtained from both synthetic and actual biological data sets show that the PMDL principle is effective in determining the MI threshold and the developed algorithm improves precision of gene regulatory network inference. Based on the sensitivity analysis of all tested cases, an optimal CMI threshold value has been identified. Finally it was observed that the performance of the algorithms saturates at a certain threshold of data size. C1 [Chaitankar, Vijender; Ghosh, Preetam; Zhang, Chaoyang] Univ So Mississippi, Sch Comp, Hattiesburg, MS 39402 USA. [Perkins, Edward J.] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Gong, Ping; Deng, Youping] SpecPro Inc, Vicksburg, MS 39180 USA. RP Chaitankar, V (reprint author), Univ So Mississippi, Sch Comp, Hattiesburg, MS 39402 USA. EM vchaitan@orca.st.usm.edu; preetam.ghosh@usm.edu; chaoyang.zhang@usm.edu FU US Army Corps of Engineers Environmental Quality Program [W912HZ-08-2-0011]; NSF EPSCoR [EPS-0903787] FX This work was supported by the US Army Corps of Engineers Environmental Quality Program under contract # W912HZ-08-2-0011 and the NSF EPSCoR project "Modeling and Simulation of Complex Systems" (NSF #EPS-0903787). NR 26 TC 10 Z9 12 U1 1 U2 7 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1752-0509 J9 BMC SYST BIOL JI BMC Syst. Biol. PD MAY 28 PY 2010 VL 4 SU 1 AR S7 DI 10.1186/1752-0509-4-S1-S7 PG 12 WC Mathematical & Computational Biology SC Mathematical & Computational Biology GA 602JV UT WOS:000278136300007 PM 20522257 ER PT J AU Farlow, J Ichou, MA Huggins, J Ibrahim, S AF Farlow, Jason Ichou, Mohamed Ait Huggins, John Ibrahim, Sofi TI Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus SO VIROLOGY JOURNAL LA English DT Article ID VIRUS-DNA POLYMERASE; RNA-CAPPING ENZYME; MODIFYING PROTEIN VP39; VACCINIA VIRUS; POXVIRUS INFECTIONS; D12 SUBUNIT; TRANSCRIPTION INITIATION; THYMIDYLATE KINASE; POLY(A) POLYMERASE; GENETIC-ANALYSIS AB We performed whole genome sequencing of a cidofovir {[(S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl) cytosine] [HPMPC]}-resistant (CDV-R) strain of Monkeypoxvirus (MPV). Whole-genome comparison with the wild-type (WT) strain revealed 55 single-nucleotide polymorphisms (SNPs) and one tandem-repeat contraction. Over one-third of all identified SNPs were located within genes comprising the poxvirus replication complex, including the DNA polymerase, RNA polymerase, mRNA capping methyltransferase, DNA processivity factor, and poly-A polymerase. Four polymorphic sites were found within the DNA polymerase gene. DNA polymerase mutations observed at positions 314 and 684 in MPV were consistent with CDV-R loci previously identified in Vaccinia virus (VACV). These data suggest the mechanism of CDV resistance may be highly conserved across Orthopoxvirus (OPV) species. SNPs were also identified within virulence genes such as the A-type inclusion protein, serine protease inhibitor-like protein SPI-3, Schlafen ATPase and thymidylate kinase, among others. Aberrant chain extension induced by CDV may lead to diverse alterations in gene expression and viral replication that may result in both adaptive and attenuating mutations. Defining the potential contribution of substitutions in the replication complex and RNA processing machinery reported here may yield further insight into CDV resistance and may augment current therapeutic development strategies. C1 [Farlow, Jason; Ichou, Mohamed Ait; Huggins, John; Ibrahim, Sofi] USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Farlow, J (reprint author), USA, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM Jason.Farlow@us.army.mil FU Defense Threat Reduction Agency [F_X003_04_RD_B/CB2851]; Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC FX This work was supported by research program funds managed by the Defense Threat Reduction Agency (plan no. F_X003_04_RD_B/CB2851). We would like to thank David Evans and Wendy Magee for their technical assistance. We also thank Katheryn Kenyon for editorial review of the manuscript. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of materials or products in this article does not constitute endorsement by the Department of Defense or the United States government. This research was supported in part by an appointment to the Postgraduate Research Participation Program at the U.S. Army Medical Research Institute of Infectious Diseases administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and USAMRMC. NR 69 TC 5 Z9 5 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1743-422X J9 VIROL J JI Virol. J. PD MAY 28 PY 2010 VL 7 AR 110 DI 10.1186/1743-422X-7-110 PG 15 WC Virology SC Virology GA 621DA UT WOS:000279553000001 PM 20509894 ER PT J AU Leitner, WW Bergmann-Leitner, ES Angov, E AF Leitner, Wolfgang W. Bergmann-Leitner, Elke S. Angov, Evelina TI Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy SO MALARIA JOURNAL LA English DT Article ID CIRCUMSPOROZOITE-PROTEIN; IMMUNE-RESPONSES; T-CELLS; IRRADIATED SPOROZOITES; EXPERIMENTAL HOSTS; MURINE MALARIA; MOSQUITO BITE; LIVER-STAGES; PROTECTION; INFECTION AB Background: The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of parasite, and are poorly understood. A challenge with live parasites is the most relevant approach to testing the efficacy of experimental malaria vaccines. Nevertheless, in the mouse models of Plasmodium berghei and Plasmodium yoelii, parasites are usually delivered by intravenous injection. This route is highly artificial and particularly in the P. berghei model produces inconsistent challenge results. The initial objective of this study was to compare an optimized intravenous (IV) delivery challenge model with an optimized single infectious mosquito bite challenge model. Finding shortcomings of both approaches, an alternative approach was explored, i. e., the subcutaneous challenge. Methods: Mice were infected with P. berghei sporozoites by intravenous (tail vein) injection, single mosquito bite, or subcutaneous injection of isolated parasites into the subcutaneous pouch at the base of the hind leg. Infection was determined in blood smears 7 and 14 days later. To determine the usefulness of challenge models for vaccine testing, mice were immunized with circumsporozoite-based DNA vaccines by gene gun. Results: Despite modifications that allowed infection with a much smaller than reported number of parasites, the IV challenge remained insufficiently reliable and reproducible. Variations in the virulence of the inoculum, if not properly monitored by the rigorous inclusion of sporozoite titration curves in each experiment, can lead to unacceptable variations in reported vaccine efficacies. In contrast, mice with different genetic backgrounds were consistently infected by a single mosquito bite, without overwhelming vaccine-induced protective immune responses. Because of the logistical challenges associated with the mosquito bite model, the subcutaneous challenge route was optimized. This approach, too, yields reliable challenge results, albeit requiring a relatively large inoculum. Conclusions: Although a single bite by P. berghei infected Anopheles mosquitoes was superior to the IV challenge route, it is laborious. However, any conclusive evaluation of a pre-erythrocytic malaria vaccine candidate should require challenge through the natural anatomic target site of the parasite, the skin. The subcutaneous injection of isolated parasites represents an attractive compromise. Similar to the mosquito bite model, it allows vaccine-induced antibodies to exert their effect and is, therefore not as prone to the artifacts of the IV challenge. C1 [Leitner, Wolfgang W.; Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Leitner, Wolfgang W.] NIAID, NIH, Bethesda, MD 20892 USA. RP Leitner, WW (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM wolfgang_leitner@nih.gov RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922 FU United States Army Medical Research and Materiel Command FX The authors would like to thank Dr. Jeffrey Lyon, for guidance on study design, Matthew C. Seguin Howard D. Stacey and Elizabeth Duncan for their expertise and technical assistance; Dr. Imogene Schneider, Megan Dowler, Jacqulin Glass and Dr. Tatyana Savranskaya for providing infected mosquitoes and for advice and technical assistance; and Diane Cooper (NIH Library) for editing. This work was supported by the United States Army Medical Research and Materiel Command. NR 46 TC 15 Z9 15 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD MAY 27 PY 2010 VL 9 AR 145 DI 10.1186/1475-2875-9-145 PG 12 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 629BA UT WOS:000280167800001 PM 20507620 ER PT J AU Ray, R Simbulan-Rosenthal, CM Keyser, BM Benton, B Anderson, D Holmes, W Trabosh, VA Daher, A Rosenthal, DS AF Ray, Radharaman Simbulan-Rosenthal, Cynthia M. Keyser, Brian M. Benton, Betty Anderson, Dana Holmes, Wesley Trabosh, Valerie A. Daher, Ahmad Rosenthal, Dean S. TI Sulfur mustard induces apoptosis in lung epithelial cells via a caspase amplification loop SO TOXICOLOGY LA English DT Article DE Sulfur mustard; Caspases; Apoptosis; Amplification loop; Bronchial/tracheal epithelial cells; Small airway epithelial cells; Rat lung ID HUMAN KERATINOCYTES; CHEMICAL WARFARE; IRANIAN VETERANS; PATHWAY; TOXICITY; DEATH; XIAP; SMAC/DIABLO; INVOLVEMENT; CALMODULIN AB Sulfur mustard (SM [bis-(2-chloroethyl) sulfide]) is a chemical warfare agent that causes skin blisters presumably due to DNA alkylation and cross-links. We recently showed that SM also induces apoptotic death in cultured normal human bronchial/tracheal epithelial (NHBE) cells and small airway epithelial cells (SAEC) in vitro. In this process, caspases-8 and -3, but not caspase-9, were strongly activated; this suggests a death receptor pathway for apoptosis. We now show that rat lungs were induced to undergo apoptosis in vivo following exposure of rats to SM by inhalation. Further study of the mechanism of apoptosis due to SM was performed with cultured NHBE cells and SAEC using tetrapeptide inhibitors of caspases-3, and -8. Inhibition of caspase-8 drastically reduced the activation of caspase-3 and almost eliminated that of caspase-9. Moreover, caspase-3 inhibition markedly reduced the activation of caspase-8 and also almost completely inhibited activation of caspase-9. These results suggest a death receptor pathway of apoptosis that utilizes a feedback amplification mechanism involving an activated death receptor complex that leads to the activation of caspase-9 via a caspase-3 pathway. These results may be important for the design of inhibitors of these pathways for therapeutic intervention to attenuate SM injury in respiratory tract lesions. Published by Elsevier Ireland Ltd. C1 [Ray, Radharaman; Keyser, Brian M.; Benton, Betty] USA, Cellular & Mol Biol Branch, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Anderson, Dana; Holmes, Wesley] USA, Med Toxicol Branch, Analyt Toxicol Div, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Simbulan-Rosenthal, Cynthia M.; Trabosh, Valerie A.; Daher, Ahmad; Rosenthal, Dean S.] Georgetown Univ, Sch Med, Dept Biochem & Mol Biol, Washington, DC USA. RP Ray, R (reprint author), USA, Cellular & Mol Biol Branch, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM radharaman.ray@us.army.mil FU NCI NIH HHS [1R01 CA100443-01A1] NR 40 TC 14 Z9 15 U1 0 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAY 27 PY 2010 VL 271 IS 3 BP 94 EP 99 DI 10.1016/j.tox.2010.03.008 PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 610YS UT WOS:000278777600004 PM 20226831 ER PT J AU Zainuddin, S Hosur, MV Zhou, Y Kumar, A Jeelani, S AF Zainuddin, S. Hosur, M. V. Zhou, Y. Kumar, Ashok Jeelani, S. TI Durability study of neat/nanophased GFRP composites subjected to different environmental conditioning SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Nanocomposites; Environmental degradation; Moisture absorption; Scanning electron microscopy ID LAYERED SILICATE NANOCOMPOSITES; REINFORCED EPOXY COMPOSITES; BARRIER PROPERTIES; CLAY NANOCOMPOSITES; WATER-ABSORPTION; GAS PERMEATION; MOISTURE; DAMAGE; GLASS; STRESSES AB Experimental investigations on the durability of E-glass/nanoclay-epoxy composites are reported. SC-15 epoxy system was modified using 1-2 wt.% of nanoclay. Extent of clay platelet exfoliation in epoxy was evaluated using X-ray diffraction (XRD). Glass fiber reinforced plastic (GFRP) composite panels were fabricated using modified epoxy and exposed to four different conditions, i.e. hot (elevated temperature-dry, wet: 60 and 80 degrees C) and cold (subzero-dry, wet) for 15,45 and 90 days. Weight change due to conditioning, quasi-static flexure and micrographic characterization were studied on the conditioned samples. Room temperature samples were also tested for baseline consideration. XRD results showed exfoliation of clay platelets in nanoclay-epoxy samples with decrease in peak intensity and increase in interplanar spacing. Samples subjected to hot-wet conditions showed higher percentage weight gain with a maximum of 4.25% in neat and 3.1% in 2 wt.% samples. Flexural tests results showed degradation with increasing time. Maximum degradation were observed for hot-wet (80 degrees C) for 90 days neat samples, i.e. 22.6% and 29.8% reduction in flexural strength and stiffness, respectively. However, less degradation was noticed for nanophased composites under similar conditions. Scanning electron microscopy (SEM) results of failed samples showed better interfacial bonding in nanophased composites. (C) 2010 Elsevier B.V. All rights reserved. C1 [Zainuddin, S.; Hosur, M. V.; Zhou, Y.; Jeelani, S.] Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. [Kumar, Ashok] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61821 USA. RP Hosur, MV (reprint author), Tuskegee Univ, Ctr Adv Mat, Tuskegee, AL 36088 USA. EM hosur@tuskegee.edu NR 45 TC 8 Z9 9 U1 0 U2 5 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD MAY 25 PY 2010 VL 527 IS 13-14 BP 3091 EP 3099 DI 10.1016/j.msea.2010.02.022 PG 9 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 586BB UT WOS:000276874700007 ER PT J AU Bhattacharyya, S Warfield, KL Ruthel, G Bavari, S Aman, MJ Hope, TJ AF Bhattacharyya, Suchita Warfield, Kelly L. Ruthel, Gordon Bavari, Sina Aman, M. Javad Hope, Thomas J. TI Ebola virus uses clathrin-mediated endocytosis as an entry pathway SO VIROLOGY LA English DT Article DE Ebola virus; Entry; Clathrin endocytic pathway; Chlorpromazine; Sucrose; Eps15 ID FOLATE RECEPTOR-ALPHA; LIPID RAFT MICRODOMAINS; EPIDERMAL-GROWTH-FACTOR; COATED PIT FORMATION; ENVELOPE PROTEINS; INFLUENZA-VIRUS; CELLULAR ENTRY; T-CELLS; INFECTION; MARBURG AB Ebola virus (EBOV) infects several cell types and while viral entry is known to be pH-dependent, the exact entry pathway(s) remains unknown. To gain insights into EBOV entry, the role of several inhibitors of clathrin-mediated endocytosis in blocking infection mediated by HIV pseudotyped with the EBOV envelope glycoprotein (EbGP) was examined. Wild type HIV and envelope-minus HIV pseudotyped with Vesicular Stomatitis Virus glycoprotein (VSVg) were used as controls to assess cell viability after inhibiting clathrin pathway. Inhibition of clathrin pathway using dominant-negative Eps15, siRNA-mediated knockdown of clathrin heavy chain, chlorpromazine and sucrose blocked EbGP pseudotyped HIV infection. Also, both chlorpromazine and Bafilomycin A1 inhibited entry of infectious EBOV. Sensitivity of EbGP pseudotyped HIV as well as infectious EBOV to inhibitors of clathrin suggests that EBOV uses clathrin-mediated endocytosis as an entry pathway. Furthermore, since chlorpromazine inhibits EBOV infection, novel therapeutic modalities could be designed based on this lead compound. (C) 2010 Elsevier Inc. All rights reserved. C1 [Bhattacharyya, Suchita; Hope, Thomas J.] Northwestern Univ, Dept Cell & Mol Biol, Feinberg Sch Med, Chicago, IL 60611 USA. [Bhattacharyya, Suchita] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA. [Warfield, Kelly L.; Ruthel, Gordon; Bavari, Sina; Aman, M. Javad] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Hope, TJ (reprint author), Northwestern Univ, Dept Cell & Mol Biol, Feinberg Sch Med, Ward 8-140,303 E Chicago Ave, Chicago, IL 60611 USA. EM thope@northwestern.edu FU National Institutes of Health [R21 AI054495]; Defense Threat Reduction Agency [F_X012_04_RD_B] FX We thank Lois Greene (National Institutes of Health), John Young (The Salk Institute for Biological Studies), Paul Bates (University of Pennsylvania), Mark Muesing (Aaron Diamond AIDS Research Center), David Rekosh and Marie-Louise Hammarskjold (University of Virginia), and the NIH AIDS reagent repository for providing plasmids and Jason Paragas (USAMRIID) for providing ZEBOV-GFP. This work was supported by the National Institutes of Health grant R21 AI054495 to T.J.H. T.J.H is an Elizabeth Glaser Scientist. Work performed at USAMRI1D was supported by a grant from Defense Threat Reduction Agency (F_X012_04_RD_B). NR 49 TC 58 Z9 62 U1 2 U2 29 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD MAY 25 PY 2010 VL 401 IS 1 BP 18 EP 28 DI 10.1016/j.virol.2010.02.015 PG 11 WC Virology SC Virology GA 582DE UT WOS:000276575000003 PM 20202662 ER PT J AU Moe, CG Reed, ML Garrett, GA Sampath, AV Alexander, T Shen, HE Wraback, M Bilenko, Y Shatalov, M Yang, JW Sun, WH Deng, JY Gaska, R AF Moe, Craig G. Reed, Meredith L. Garrett, Gregory A. Sampath, Anand V. Alexander, Troy Shen, Hongen Wraback, Michael Bilenko, Yuriy Shatalov, Maxim Yang, Jinwei Sun, Wenhong Deng, Jianyu Gaska, Remis TI Current-induced degradation of high performance deep ultraviolet light emitting diodes SO APPLIED PHYSICS LETTERS LA English DT Article DE light emitting diodes; photoluminescence; p-n junctions; thermal stresses ID NITRIDES; LEDS AB Lifetime measurements on single-chip, packaged 285 nm light-emitting diodes (LEDs) performed under constant current injection at 20 and 75 mA, were compared to the performance of unbiased LEDs baked at the equivalent operating junction temperatures. The thermally stressed devices showed a lesser degradation than those electrically stressed, indicating that elevated temperature alone does not cause degradation. Despite a decay to less than half of the initial power under current injection, time-resolved photoluminescence of the active region exhibits little change, while capacitance-voltage measurements imply that the reduced efficiency and power decay originate from the generation of point defects near the p-side of the p-n junction. (C) 2010 American Institute of Physics. [doi:10.1063/1.3435485] C1 [Moe, Craig G.; Reed, Meredith L.; Garrett, Gregory A.; Sampath, Anand V.; Alexander, Troy; Shen, Hongen; Wraback, Michael] USA, Sensors & Electron Devices Directorate, Res Lab, RDRL SEE M, Adelphi, MD 20783 USA. [Bilenko, Yuriy; Shatalov, Maxim; Yang, Jinwei; Sun, Wenhong; Deng, Jianyu; Gaska, Remis] Sensor Elect Technol Inc, Columbia, SC 29209 USA. RP Moe, CG (reprint author), USA, Sensors & Electron Devices Directorate, Res Lab, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM craig.moe@arl.army.mil FU ARL-Boston University Collaborative Research and Development FX Dr. Moe was supported in this work through an ARL-Boston University Collaborative Research and Development Agreement. NR 16 TC 22 Z9 23 U1 5 U2 25 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 24 PY 2010 VL 96 IS 21 AR 213512 DI 10.1063/1.3435485 PG 3 WC Physics, Applied SC Physics GA 603BP UT WOS:000278183200088 ER PT J AU Clifton, GT Clive, KS Patil, R Holmes, JP Benavides, LC Gates, JD Tyler, J Mittendorf, EA Ponniah, S Peoples, GE AF Clifton, G. T. Clive, K. S. Patil, R. Holmes, J. P. Benavides, L. C. Gates, J. D. Tyler, J. Mittendorf, E. A. Ponniah, S. Peoples, G. E. TI Effect of a novel II-key hybrid HER2/nen peptide (AE37) vaccine with GM-CSF as compared to GM-CSF alone on levels of regulatory T-cell (Treg) populations SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Windber Med Ctr, Windber, PA USA. Naval Med Ctr San Diego, San Diego, CA USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2010 VL 28 IS 15 SU S MA 2565 PG 1 WC Oncology SC Oncology GA V30YT UT WOS:000208852003156 ER PT J AU Clive, KS Summers, TA Clifton, GT Patil, R Tyler, J Holmes, JP Mittendorf, EA Stojadinovic, A Ponniah, S Peoples, GE AF Clive, K. S. Summers, T. A. Clifton, G. T. Patil, R. Tyler, J. Holmes, J. P. Mittendorf, E. A. Stojadinovic, A. Ponniah, S. Peoples, G. E. TI Assessment of circulating tumor cell (CTC) patterns among disease-free breast cancer patients vaccinated with adjuvant HER2/neu-based peptide vaccines. SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Windber Med Ctr, Windber, PA USA. Naval Med Ctr San Diego, San Diego, CA USA. Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. USUHS, Canc Vaccine Dev Program, US Mil Canc Inst, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2010 VL 28 IS 15 SU S MA 2542 PG 1 WC Oncology SC Oncology GA V30YT UT WOS:000208852003133 ER PT J AU Ellsworth, RE Field, LA Love, B Kane, JL Hooke, JA Shriver, CD AF Ellsworth, R. E. Field, L. A. Love, B. Kane, J. L. Hooke, J. A. Shriver, C. D. TI Breast cancer metastasis gene signature: The search for the holy grail SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Henry M Jackson Fdn Adv Mil Med, Windber, PA USA. Windber Res Inst, Windber, PA USA. BioReka, Lutherville Timonium, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2010 VL 28 IS 15 SU S MA 1075 PG 1 WC Oncology SC Oncology GA V30YT UT WOS:000208852002590 ER PT J AU Parker, PM Rice, KR Chen, Y McLeod, DG Brassell, SA AF Parker, P. M. Rice, K. R. Chen, Y. McLeod, D. G. Brassell, S. A. TI Prostate cancer in men under the age of 50: A comparison. of race and outcomes SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Ctr Prostate Dis Res, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2010 VL 28 IS 15 SU S MA 4654 PG 1 WC Oncology SC Oncology GA V30YT UT WOS:000208852004023 ER PT J AU Waxman, AJ Mink, P Devesa, S Anderson, WF Weiss, BM Kristinsson, S McGlynn, K Landgren, O AF Waxman, A. J. Mink, P. Devesa, S. Anderson, W. F. Weiss, B. M. Kristinsson, S. McGlynn, K. Landgren, O. TI Racial disparities in incidence and survival among 37,977 blacks and whites with multiple myeloma SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 NCI, Med Oncol Branch, Bethesda, MD 20892 USA. Emory Univ, Atlanta, GA 30322 USA. NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. NCI, Dept Hlth & Human Serv, NIH, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Karolinska Univ Hosp & Inst, Stockholm, Sweden. RI Kristinsson, Sigurdur /M-2910-2015 OI Kristinsson, Sigurdur /0000-0002-4964-7476 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2010 VL 28 IS 15 SU S MA 8115 PG 1 WC Oncology SC Oncology GA V30YT UT WOS:000208852005135 ER PT J AU Wolf, SL Qin, R Menon, SP Rowland, KM Kugler, JW Flynn, PJ Christian, D Satele, D Berenberg, JL Loprinzi, CL AF Wolf, S. L. Qin, R. Menon, S. P. Rowland, K. M. Kugler, J. W. Flynn, P. J. Christian, D. Satele, D. Berenberg, J. L. Loprinzi, C. L. TI Evaluation of a urea/lactic acid-based topical keratolytic agent (ULABTKA) for prevention of capecitabine-induced hand and foot syndrome (HFS): NCCTG trial N05C5 SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Meeting Abstract C1 Mayo Clin, Rochester, MN USA. Pk Nicollet Canc Ctr, St Louis Pk, MN USA. Carle Clin Assoc, Urbana, IL USA. Illinois Canc Care, Peoria, IL USA. Minnesota Oncol, Minneapolis, MN USA. Missouri Baptist Med Ctr, St Louis, MO USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAY 20 PY 2010 VL 28 IS 15 SU S MA 9017 PG 1 WC Oncology SC Oncology GA V30YT UT WOS:000208852005284 ER PT J AU Laoire, CO Mukerjee, S Abraham, KM Plichta, EJ Hendrickson, MA AF Laoire, Cormac O. Mukerjee, Sanjeev Abraham, K. M. Plichta, Edward J. Hendrickson, Mary A. TI Influence of Nonaqueous Solvents on the Electrochemistry of Oxygen in the Rechargeable Lithium-Air Battery SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID ORGANIC ELECTROLYTE BATTERY; N-NONANE; TETRABUTYLAMMONIUM; DENSITY; SYSTEMS; HEXAFLUOROPHOSPHATE; PERMITTIVITY; TEMPERATURES; PERFORMANCE; SOLVATION AB A fundamental study of the influence of solvents on the oxygen reduction reaction (ORR) in nonaqueous electrolytes has been carried out for elucidating the mechanism of the oxygen electrode processes in the rechargeable Li-air battery. Using either tetrabutylammonium hexafluorophosphate (TBAPF(6)) or lithium hexafluorophosphate (LiPF(6)) electrolyte solutions in four different solvents, namely, dimethyl sulfoxide (DMSO), acetonitrile (MeCN), dimethoxyethane (DME), and tetraethylene glycol dimethyl ether (TEGDME), possessing a range of donor numbers (DN), we have determined that the solvent and the supporting electrolyte cations in the solution act in concert to influence the nature of reduction products and their rechargeability. In solutions containing TBA(+), O(2) reduction is a highly reversible one-electron process involving the O(2)/O(2)(-) couple. On the other hand, in Li(+)-containing electrolytes relevant to the Li-air battery, O(2) reduction proceeds in a stepwise fashion to form O(2)(-), O(2)(2-), and O(2-) as products. These reactions in the presence of Li(+) are irreversible or quasi-reversible electrochemical processes, and the solvents have significant influence on the kinetics, and reversibility or lack thereof, of the different reduction products. The stabilization of the one-electron reduction product, superoxide (O(2)(-)) in TBA(+) solutions in all of the solvents examined can be explained using Pearson's hard soft acid base (HSAB) theory involving the formation of the TBA(+)-O(2)(-) complex. The HSAB theory coupled with the relative stabilities of the Li(+)-(solvent)(n) complexes existing in the different solvents also provide an explanation for the different O(2) reduction products formed in Li(+)-conducting electrolyte solutions. Reversible reduction of O(2) to long-lived superoxide in a Li(+)-conducting electrolyte in DMSO has been shown for the first time here, Our results provide a rational approach to the selection of organic electrolyte solutions for use in the rechargeable Li-air battery. C1 [Laoire, Cormac O.; Mukerjee, Sanjeev; Abraham, K. M.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA. [Plichta, Edward J.; Hendrickson, Mary A.] USA, CERDEC, Army Power Div, Ft Monmouth, NJ 07703 USA. RP Abraham, KM (reprint author), Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA. EM kmabraham@comcast.net FU U.S. Army CERDEC [GTS-S-6-1-437] FX U.S. Army CERDEC through Subcontract No. GTS-S-6-1-437 supported this work. NR 33 TC 423 Z9 434 U1 29 U2 381 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAY 20 PY 2010 VL 114 IS 19 BP 9178 EP 9186 DI 10.1021/jp102019y PG 9 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 593YT UT WOS:000277500000066 ER PT J AU Zhong, XL Pandey, R Rocha, AR Karna, SP AF Zhong, Xiaoliang Pandey, Ravindra Rocha, Alexandre Reily Karna, Shashi P. TI Can Single-Atom Change Affect Electron Transport Properties of Molecular Nanostructures such as C-60 Fullerene? SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article AB At the nanoscale, even a single atom change in the structure can noticeably alter the properties, and therefore, the application space of materials. We examine this critical behavior of nanomaterials using fullerene as a model structure by a first-principles density functional theory method coupled with nonequilibrium Green's function formalism. Two different configurations, namely, (i) endohedral (B@C-60 and N@C-60), in which the doping atom is encapsulated inside the fullerene cage, and (ii) substitutional (BC59 and NC59), in which the doping atom replaces a C atom on the fullerene cage, are considered. The calculated results reveal that the conductivity for the doped fullerene is higher than that of the pristine fullerene. In the low-bias regime, the current (I) voltage (V) characteristic of the endohedral as well as the substitutional configurations are very similar. However, as the external bias increases beyond 1.0 V, the substitutional BC59 fullerene exhibits a considerably higher magnitude of current than all other species considered, thus suggesting that it can be an effective semiconductor in p-type devices. C1 [Zhong, Xiaoliang; Pandey, Ravindra] Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. [Rocha, Alexandre Reily] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, Brazil. [Karna, Shashi P.] USA, Res Lab, Weap & Mat Res Directorate, RDRL WM, Aberdeen Proving Ground, MD 21005 USA. RP Pandey, R (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. EM pandey@mtu.edu; shashi.karna@us.army.mil RI Rocha, Alexandre/F-9504-2010; Zhong, Xiaoliang/B-2220-2012 OI Rocha, Alexandre/0000-0001-8874-6947; FU Army Research Office [W911NF-09-1-0221] FX Helpful discussions with Haiying He and S. Gowtham are acknowledged. The work at Michigan Technological University was performed under support by the Army Research Office through Contract Number W911NF-09-1-0221. NR 30 TC 14 Z9 14 U1 0 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD MAY 20 PY 2010 VL 1 IS 10 BP 1584 EP 1589 DI 10.1021/jz100360t PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 600HP UT WOS:000277976400014 ER PT J AU Koehler, RN Walsh, AM Sanders-Buell, EE Eller, LA Eller, M Currier, JR Bautista, CT Wabwire-Mangen, F Hoelscher, M Maboko, L Kim, J Michael, NL Robb, ML McCutchan, FE Kijak, GH AF Koehler, Rebecca N. Walsh, Anne M. Sanders-Buell, Eric E. Eller, Leigh Anne Eller, Michael Currier, Jeffrey R. Bautista, Christian T. Wabwire-Mangen, Fred Hoelscher, Michael Maboko, Leonard Kim, Jerome Michael, Nelson L. Robb, Merlin L. McCutchan, Francine E. Kijak, Gustavo H. TI High-Throughput High- Resolution Class I HLA Genotyping in East Africa SO PLOS ONE LA English DT Article ID HISTOCOMPATIBILITY COMPLEX LOCI; HUMAN-LEUKOCYTE ANTIGENS; REAL-TIME PCR; HUMAN GENOME; NATURAL-SELECTION; RAKAI DISTRICT; HAPLOTYPE MAP; MBEYA REGION; 5 CONTINENTS; B ALLELES AB HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria, and tuberculosis, but the HLA genetic diversity in this region remains incompletely described. This is a major obstacle for the design and evaluation of preventive vaccines. Available HLA typing techniques, that provide the 4-digit level resolution needed to interpret immune responses, lack sufficient throughput for large immunoepidemiological studies. Here we present a novel HLA typing assay bridging the gap between high resolution and high throughput. The assay is based on real-time PCR using sequence-specific primers (SSP) and can genotype carriers of the 49 most common East African class I HLA-A, -B, and -C alleles, at the 4-digit level. Using a validation panel of 175 samples from Kampala, Uganda, previously defined by sequence-based typing, the new assay performed with 100% sensitivity and specificity. The assay was also implemented to define the HLA genetic complexity of a previously uncharacterized Tanzanian population, demonstrating its inclusion in the major East African genetic cluster. The availability of genotyping tools with this capacity will be extremely useful in the identification of correlates of immune protection and the evaluation of candidate vaccine efficacy. C1 [Koehler, Rebecca N.; Walsh, Anne M.; Sanders-Buell, Eric E.; Currier, Jeffrey R.; Bautista, Christian T.; Robb, Merlin L.; McCutchan, Francine E.; Kijak, Gustavo H.] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. [Eller, Leigh Anne; Eller, Michael] Makerere Univ, Walter Reed Res Project, Henry M Jackson Fdn, Kampala, Uganda. [Hoelscher, Michael] Univ Munich, Dept Trop Med & Infect Dis, Munich, Germany. [Hoelscher, Michael; Maboko, Leonard] Mbeya Med Res Program, Mbeya, Tanzania. [Kim, Jerome; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA. RP Koehler, RN (reprint author), Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD USA. EM gkijak@hivresearch.org RI Bautista, Christian/B-2812-2011; Hoelscher, Michael/D-3436-2012 FU Henry M. Jackson Foundation; United States Department of Defense; National Institute for Allergy and Infectious Diseases, National Institutes of Health [Y1-AI-2642-11] FX This work was supported through a cooperative agreement between the Henry M. Jackson Foundation for the Advancement of Military Medicine and the United States Department of Defense, by the National Institute for Allergy and Infectious Diseases, National Institutes of Health ("HIV Vaccine Research and Development - Project 2'' Y1-AI-2642-11). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 79 TC 4 Z9 4 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 20 PY 2010 VL 5 IS 5 AR e10751 DI 10.1371/journal.pone.0010751 PG 18 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 600VP UT WOS:000278017300022 PM 20505773 ER PT J AU Mulligan, CP Blanchet, TA Gall, D AF Mulligan, C. P. Blanchet, T. A. Gall, D. TI CrN-Ag nanocomposite coatings: High-temperature tribological response SO WEAR LA English DT Article DE Sliding friction; Sliding wear; Solid lubricants; High temperature; Nanocomposite coating; CrN-Ag ID SELF-LUBRICATING COATINGS; THIN-FILMS; SILVER; MICROSTRUCTURE; MOLYBDENUM; DIFFUSION; FRICTION; BEHAVIOR; GROWTH AB 5 mu m thick CrN-Ag composite layers, containing 22 at.% Ag solid lubricant, were deposited by reactive magnetron co-sputtering on 440C stainless-steel substrates at T(s) = 300, 400, 500, and 600 degrees C. Vacuum annealing experiments at T(a) = 425,525, and 625 degrees C show that Ag diffuses to the coating surface to form lubricious surface aggregates and that the rate for Ag lubricant transport increases with T(a) > T(s), as determined by quantitative electron microscopy surface analyses. However, the Ag remains in the CrN matrix for T(a) < T(s). This is attributed to an increasing Ag aggregate size within the composite with increasing T(s), leading to a decrease in the chemical potential and, in turn, negligible diffusion until T(a) exceeds T(s). The tribological response during ball-on-disk sliding in ambient air against 6-mm-alumina balls was found to depend strongly on both T(s) and the testing temperature T(t) = 450, 550, and 650 degrees C. The key parameter that determines lubricant transport and, in turn, tribological properties is the temperature difference Delta T = T(t) - T(s). For Delta T<0, the lubricious Ag within the CrN matrix causes a moderate (25-35%) reduction in the friction coefficient from mu = 0.41-0.51 for pure CrN to mu = 0.31-0.34 for the composite. In contrast, at Delta T>0, the Ag diffuses to the surface, partially transfers to the counterface, and forms a lubricious interface layer, reducing the friction by up to 60% to mu = 0.16-0.24. However, continuous wear at Delta T>0 causes Ag depletion which results in an increasing friction and wear, and ultimately mechanical failure of the coating. The lubricant transport rate and, in turn, the lifetime before the Ag is depleted depend both strongly on Delta T, and can therefore be optimized for a given application. Published by Elsevier B.V. C1 [Mulligan, C. P.] USA, ARDEC, Benet Labs, Watervliet, NY 12189 USA. [Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Blanchet, T. A.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. RP Mulligan, CP (reprint author), USA, ARDEC, Benet Labs, 1 Buffington St,RDAR WSB LB, Watervliet, NY 12189 USA. EM c.mulligan@us.army.mil RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 FU United States Army through Armament Research, Development and Engineering Center (ARDEC); National Science Foundation [CMMI-0653843, DMR-0645312] FX This research was supported by the United States Army TEX3 Program, through the Armament Research, Development and Engineering Center (ARDEC), and by the National Science Foundation under Grant Nos. CMMI-0653843 and DMR-0645312. NR 27 TC 31 Z9 38 U1 6 U2 20 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0043-1648 J9 WEAR JI Wear PD MAY 20 PY 2010 VL 269 IS 1-2 BP 125 EP 131 DI 10.1016/j.wear.2010.03.015 PG 7 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA 606TR UT WOS:000278451300016 ER PT J AU Geisbert, TW Daddario-DiCaprio, KM Hickey, AC Smith, MA Chan, YP Wang, LF Mattapallil, JJ Geisbert, JB Bossart, KN Broder, CC AF Geisbert, Thomas W. Daddario-DiCaprio, Kathleen M. Hickey, Andrew C. Smith, Mark A. Chan, Yee-Peng Wang, Lin-Fa Mattapallil, Joseph J. Geisbert, Joan B. Bossart, Katharine N. Broder, Christopher C. TI Development of an Acute and Highly Pathogenic Nonhuman Primate Model of Nipah Virus Infection SO PLOS ONE LA English DT Article ID EMERGENT DEADLY PARAMYXOVIRUS; HENDRA-VIRUS; EQUINE MORBILLIVIRUS; RECEPTOR-BINDING; SUBUNIT VACCINE; G-GLYCOPROTEIN; HAMSTER MODEL; FLYING-FOXES; PIG-FARMERS; ENCEPHALITIS AB Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75 percent and there are no vaccines or treatments approved for human use. Guinea pigs, hamsters, cats, ferrets, pigs and most recently squirrel monkeys (New World monkey) have been evaluated as animal models of human NiV infection, and with the exception of the ferret, no model recapitulates all aspects of NiV-mediated disease seen in humans. To identify a more viable nonhuman primate (NHP) model, we examined the pathogenesis of NiV in African green monkeys (AGM). Exposure of eight monkeys to NiV produced a severe systemic infection in all eight animals with seven of the animals succumbing to infection. Viral RNA was detected in the plasma of challenged animals and occurred in two of three subjects as a peak between days 7 and 21, providing the first clear demonstration of plasma-associated viremia in NiV experimentally infected animals and suggested a progressive infection that seeded multiple organs simultaneously from the initial site of virus replication. Unlike the cat, hamster and squirrel monkey models of NiV infection, severe respiratory pathology, neurological disease and generalized vasculitis all manifested in NiV-infected AGMs, providing an accurate reflection of what is observed in NiV-infected humans. Our findings demonstrate the first consistent and highly pathogenic NHP model of NiV infection, providing a new and critical platform in the evaluation and licensure of either passive and active immunization or therapeutic strategies for human use. C1 [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Geisbert, Joan B.; Bossart, Katharine N.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. [Geisbert, Thomas W.; Bossart, Katharine N.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Hickey, Andrew C.; Smith, Mark A.; Chan, Yee-Peng; Mattapallil, Joseph J.; Broder, Christopher C.] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD USA. [Smith, Mark A.] USA, Div Pathol, Med Res Inst Infect Dis, Frederick, MD USA. [Wang, Lin-Fa] Australian Commonwealth Sci & Res Org, Australian Anim Hlth Lab, Geelong, Vic, Australia. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. EM cbroder@usuhs.mil OI Bossart, Katharine/0000-0001-6886-6896 FU Department of Health and Human Services, National Institutes of Health [AI082121, AI057159, DE018339, DE019397, AI071812, AI054715, AI077995] FX This study was supported in part by the Department of Health and Human Services, National Institutes of Health, grants AI082121 and AI057159 to TWG; DE018339, DE019397 and AI071812 to JJM, and AI054715 and AI077995 to CCB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 48 TC 54 Z9 54 U1 0 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 18 PY 2010 VL 5 IS 5 AR e10690 DI 10.1371/journal.pone.0010690 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 597RA UT WOS:000277776500007 PM 20502528 ER PT J AU Nalca, A Zumbrun, EE AF Nalca, Aysegul Zumbrun, Elizabeth E. TI ACAM2000 (TM): The new smallpox vaccine for United States Strategic National Stockpile SO DRUG DESIGN DEVELOPMENT AND THERAPY LA English DT Review DE smallpox; vaccinia; variola; vaccine; efficacy; safety AB Smallpox was eradicated more than 30 years ago, but heightened concerns over bioterrorism have brought smallpox and smallpox vaccination back to the forefront. The previously licensed smallpox vaccine in the United States, Dryvax (R) (Wyeth Laboratories, Inc.), was highly effective, but the supply was insufficient to vaccinate the entire current US population. Additionally, Dryvax (R) had a questionable safety profile since it consisted of a pool of vaccinia virus strains with varying degrees of virulence, and was grown on the skin of calves, an outdated technique that poses an unnecessary risk of contamination. The US government has therefore recently supported development of an improved live vaccinia virus smallpox vaccine. This initiative has resulted in the development of ACAM2000 (TM) (Acambis, Inc.(TM)), a single plaque-purified vaccinia virus derivative of Dryvax (R), aseptically propagated in cell culture. Preclinical and clinical trials reported in 2008 demonstrated that ACAM2000 (TM) has comparable immunogenicity to that of Dryvax (R), and causes a similar frequency of adverse events. Furthermore, like Dryvax (R), ACAM2000 (TM) vaccination has been shown by careful cardiac screening to result in an unexpectedly high rate of myocarditis and pericarditis. ACAM2000 (TM) received US Food and Drug Administration (FDA) approval in August 2007, and replaced Dryvax (R) for all smallpox vaccinations in February 2008. Currently, over 200 million doses of ACAM2000 (TM) have been produced for the US Strategic National Stockpile. This review of ACAM2000 (TM) addresses the production, characterization, clinical trials, and adverse events associated with this new smallpox vaccine. C1 [Nalca, Aysegul; Zumbrun, Elizabeth E.] USA, Ctr Aerobiol Sci, Med Res Inst Infect Dis USAMRIID, Ft Detrick, MD 21702 USA. RP Nalca, A (reprint author), USA, Med Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA. EM aysegul.nalca@us.army.mil OI Zumbrun, Elizabeth/0000-0002-9897-7201 NR 55 TC 37 Z9 38 U1 1 U2 5 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1177-8881 J9 DRUG DES DEV THER JI Drug Des. Dev. Ther. PD MAY 17 PY 2010 VL 4 BP 71 EP 79 PG 9 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA V20YJ UT WOS:000208175000001 PM 20531961 ER PT J AU Shao, P Li, YJ Yi, J Pritchett, TM Sun, WF AF Shao, Pin Li, Yunjing Yi, Jing Pritchett, Timothy M. Sun, Wenfang TI Cyclometalated Platinum(II) 6-Phenyl-4-(9,9-dihexylfluoren-2-yl)-2,2 '-bipyridine Complexes: Synthesis, Photophysics, and Nonlinear Absorption SO INORGANIC CHEMISTRY LA English DT Article ID STRUCTURAL-CHARACTERIZATION; PHENYLACETYLIDE COMPLEXES; LUMINESCENCE PROPERTIES; CONJUGATED POLYMERS; OXIDATIVE ADDITION; EXCITED-STATE; SIDE-CHAINS; PHOTOLUMINESCENCE; LIGANDS; DYES AB A series of mononuclear and dinuclear cyclometalated platinum(II) 6-phenyl-4-(9,9-dihexylfluoren-2-yl)-2,2'-bipyridine complexes (F-1-F-5) were synthesized and their photophysical properties were systematically investigated. All complexes exhibit strong (1)pi,pi* absorption bands in the UV region, and a broad, structureless charge transfer band in the visible region. The charge-transfer band is broadened and red-shifted for F-3-F-5 compared to those for F-1 and F-2 because of the electron-donating acetylide ligand and the involvement of the ligand-to-ligand charge transfer character. The molar extinction coefficients for the dinuclear complex F-5 are much higher than those for the mononuclear complexes F-1-F-4, indicating the electronic coupling through the bridge ligand. All complexes are emissive in solution at room temperature and in glassy matrix at 77 K. When excited at the charge transfer absorption band, the complexes exhibit a long-lived red/orange emission around 600 nm, which is attributed to a triplet metal-to-ligand charge transfer/intraligand charge transfer emission ((3)MLCT/(3)ILCT). For emission at 77 K, the emitting state is tentatively assigned as (3)MLCT for F-2-F-4, and (3)MLCT/(3)pi,pi* for F-1 and F-5 taking into account the emission energy, the shape of the spectrum, the lifetime, and the thermally induced Stokes shift. F-1-F-4 exhibit broad triplet transient difference absorption in the visible to the near-IR region, with a lifetime comparable to those measured from the decay of the (3)MLCT/(3)ILCT emission. Therefore, F-1-F-4 give rise to a strong reverse saturable absorption for ns laser pulses at 532 nm. Z-scan experiments were carried out at 532 nm using both ns and ps laser pulses, and the experimental data was fitted by a five-band model to extract the singlet and triplet excited-state absorption cross sections. The degree of reverse saturable absorption follows this trend: F-1 = F-2 > F-3 > F-4 > F-5, which is mainly determined by the ratio of the triplet excited-state absorption cross-section to that of the ground-state and the triplet excited-state quantum yield. Comparison of the photophysics of F-1, F-2, and F-3 to those of their corresponding Pt complexes without the fluorenyl substituent discovers that F-1-F-3 exhibit larger molar extinction coefficients for their low-energy charge transfer absorption band, longer triplet excited-state lifetimes, higher emission quantum yields, and increased ratios of the excited-state absorption cross-section to that of the ground-state. C1 [Shao, Pin; Li, Yunjing; Yi, Jing; Sun, Wenfang] N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58108 USA. [Yi, Jing; Pritchett, Timothy M.] USA, Res Lab, AMSRD ARL SE EM, Adelphi, MD 20783 USA. RP Sun, WF (reprint author), N Dakota State Univ, Dept Chem & Mol Biol, Fargo, ND 58108 USA. EM wenfang.sun@ndsu.edu RI shao, pin/D-5790-2011 FU National Science Foundation (CAREER) [CHE-0449598]; Army Research Laboratory [W911N17-06-2-0032] FX Financial support from the National Science Foundation (CAREER CHE-0449598) and the Army Research Laboratory (W911N17-06-2-0032) is greatly appreciated. We are grateful to Dr. Joy E. Haley at the UES Inc. and the Air Force Research Laboratory for measuring the singlet excited-state lifetime and to Zhongjing Li at Sun's group at NDSU for measuring the fluorescence spectra of the related ligands and fluorene. NR 58 TC 48 Z9 48 U1 3 U2 27 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0020-1669 J9 INORG CHEM JI Inorg. Chem. PD MAY 17 PY 2010 VL 49 IS 10 BP 4507 EP 4517 DI 10.1021/ic902281a PG 11 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 592MS UT WOS:000277383900017 PM 20405851 ER PT J AU Seehusen, DA Baird, D Bode, D AF Seehusen, Dean A. Baird, Drew Bode, David TI Primary Care of Adult Survivors of Childhood Cancer SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CHILDRENS ONCOLOGY GROUP; FOLLOW-UP GUIDELINES; HEALTH; MORTALITY AB There are approximately 300,000 survivors of childhood cancer in the United States, and most of them receive their medical care from primary care physicians. Adult survivors of childhood cancer are at considerable risk of long-term morbidity and mortality beyond the recurrence of their primary malignancy. Late adverse effects can impair organ function, stunt growth and development, and cause neurocognitive dysfunction and secondary malignancies. To address the need for systematic, comprehensive care of this expanding high-risk patient population, the Children's Oncology Group has developed long-term follow-up guidelines. Proper use of these guidelines will allow primary care physicians to understand a patient's individual risk, provide additional screening as needed, and identify late adverse effects of childhood cancer early. The foundation of the care of an adult survivor of a childhood cancer is a complete, accurate account of the patient's cancer and subsequent therapy in the form of a Summary of Cancer Treatment. A complete Summary of Cancer Treatment allows a primary care physician to use the long-term follow-up guidelines to create an individualized care plan. This article will review the late adverse effects of childhood cancer therapy and the transition of patients from pediatric oncologists to physicians in adulthood, and explain how primary care physicians can use these tools to provide appropriate care to adult survivors of childhood cancer. (Am Fam Physician. 2010; 81(10):1250-1255. Copyright (C) 2010 American Academy of Family Physicians.) C1 [Seehusen, Dean A.] Evans Army Community Hosp, Family Med Serv, Ft Carson, CO 80913 USA. [Baird, Drew] Carl R Darnall Army Med Ctr, Ft Hood, TX USA. [Bode, David] Brooke Army Med Ctr, Dept Adolescent Med, Ft Sam Houston, TX 78234 USA. RP Seehusen, DA (reprint author), Evans Army Community Hosp, Family Med Serv, Ft Carson, CO 80913 USA. EM dseehusen@msn.com NR 19 TC 10 Z9 10 U1 1 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAY 15 PY 2010 VL 81 IS 10 BP 1250 EP 1255 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 601PE UT WOS:000278073700009 PM 20507049 ER PT J AU Wellenius, P Smith, ER LeBoeuf, SM Everitt, HO Muth, JF AF Wellenius, P. Smith, E. R. LeBoeuf, S. M. Everitt, H. O. Muth, J. F. TI Optimal composition of europium gallium oxide thin films for device applications SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID EU-DOPED GAN; ELECTROLUMINESCENT; LUMINESCENCE; PHOSPHORS; DISPLAYS; EU2O3 AB Europium gallium oxide (Eu(x)Ga(1-x))(2)O(3) thin films were deposited on sapphire substrates by pulsed laser deposition with varying Eu content from x=2.4 to 20 mol %. The optical and physical effects of high europium concentration on these thin films were studied using photoluminescence (PL) spectroscopy, x-ray diffraction (XRD), and Rutherford backscattering spectrometry. PL spectra demonstrate that emission due to the (5)D(0) to (7)F(J) transitions in Eu(3+) grows linearly with Eu content up to 10 mol %. Time-resolved PL indicates decay parameters remain similar for films with up to 10 mol % Eu. At 20 mol %, however, PL intensity decreases substantially and PL decay accelerates, indicative of parasitic energy transfer processes. XRD shows films to be polycrystalline and beta-phase for low Eu compositions. Increasing Eu content beyond 5 mol % does not continue to modify the film structure and thus, changes in PL spectra and decay cannot be attributed to structural changes in the host. These data indicate the optimal doping for optoelectronic devices based on (Eu(x)Ga(1-x))(2)O(3) thin films is between 5 and 10 mol %. (C) 2010 American Institute of Physics. [doi:10.1063/1.3319670] C1 [Wellenius, P.; Muth, J. F.] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. [Smith, E. R.] Kratos Def & Secur Solut Inc, Huntsville, AL 35805 USA. [LeBoeuf, S. M.] Valencell Inc, Raleigh, NC 27615 USA. [Everitt, H. O.] Duke Univ, Dept Phys, Durham, NC 27708 USA. [Everitt, H. O.] USA, Aviat & Missile RD&E Ctr, Redstone Arsenal, AL 35898 USA. RP Muth, JF (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM muth@unity.ncsu.edu RI Everitt, Henry/L-7118-2013; Muth, John/E-9027-2012 OI Everitt, Henry/0000-0002-8141-3768; Muth, John/0000-0002-2488-7721 FU NSF [STTR IIP-0712295]; Army's competitive in-house laboratory independent research program; ONR FX The authors wish to thank Dr. J. Derek Demaree for RBS analysis and results, and Henry H. Everitt for assistance with TRPL data collection. The authors acknowledge financial support from NSF (Grant No. STTR IIP-0712295), the Army's competitive in-house laboratory independent research program, and the ONR Young Investigator Program. NR 27 TC 8 Z9 9 U1 0 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 2010 VL 107 IS 10 AR 103111 DI 10.1063/1.3319670 PG 5 WC Physics, Applied SC Physics GA 603BH UT WOS:000278182400011 ER PT J AU Capacio, BR Dusick, B Smith, JR McDonough, JH Shih, TM AF Capacio, B. R. Dusick, B. Smith, J. R. McDonough, J. H. Shih, T-M TI A liquid chromatographic-mass spectrometric (LC-MS) method for the analysis of the bis-pyridinium oxime ICD-585 in plasma: Application in a guinea pig model SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article; Proceedings Paper CT 12th International Medical Chemical Defence Conference CY APR 22-23, 2009 CL Munich, GERMANY DE Nerve agent; bis-Pyridinium oxime(s); Pharmacokinetics; Analysis; Liquid chromatography; Mass spectrometry; GC-MS ID GF; EFFICACY AB In recent animal studies, several novel oxime compounds that are better than 2-PAM as antidotes against selected organophosphate (OP) nerve agents have been identified. The purpose of this study was to develop and validate a liquid chromatographic-mass spectrometric (LC-MS) method for analysis of the bis-pyridinium oxime ICD-585 (1-(2-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)propane) in plasma and to establish the utility of the method in a guinea pig model. Calibration curves were prepared using ICD-585-spiked plasma at concentrations from 0.156 to 10 mu g/ml. Curves were run over a 1-month time frame and a total of 13 (n = 13) were generated. The lower limit of quantification (LLOQ) was determined to be 0.216 mu g/ml. Intra- and inter-day variability was assessed by studying precision and accuracy. For intra-day studies, data from the precision determinations indicated that the % CV's ranged from 4.28 to 14.98%. The % error in the accuracy assessments ranged from -8.73 to 4.61%. For interday studies, precision data ranged from 3.53 to 13.20%. The % error in the accuracy assessments ranged from 0.39 to 13.77%. Room temperature, freeze-thaw and autosampler stability was also examined. For all 3 stability studies, the compound remained within +/- 15% of the initial analysis. Application of the method was demonstrated by analyzing samples from guinea pigs challenged with sarin (GB) or cyclosarin (GF) (1 x LD(50)) followed with intramuscular ICD-585 (58 mu M/kg, 21.8 mg/kg). At 55 min after oxime administration, mean (+/- SD) plasma concentrations were 15.98 (+/- 4.88) mu g/mland 14.57 (+/- 3.70) mu g/ml in GB- and GF-exposed animals, respectively. In summary, studies have been carried out to verify the sensitivity, precision and accuracy of the assay as well as the stability of the analyte under various conditions. The method has been demonstrated to be applicable to the analysis of plasma from nerve agent-exposed guinea pigs. Published by Elsevier B.V. C1 [Capacio, B. R.; Dusick, B.; Smith, J. R.; McDonough, J. H.; Shih, T-M] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Capacio, BR (reprint author), USA, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM benedict.capacio@us.army.mil NR 11 TC 3 Z9 3 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 J9 J CHROMATOGR B JI J. Chromatogr. B PD MAY 15 PY 2010 VL 878 IS 17-18 SI SI BP 1420 EP 1425 DI 10.1016/j.jchromb.2009.12.011 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 601RU UT WOS:000278082300025 PM 20044318 ER PT J AU Ritenour, AE Christy, RJ Roe, JL Baer, DG Dubick, MA Wade, CE Holcomb, JB Walters, TJ AF Ritenour, Amber E. Christy, Robert J. Roe, Janet L. Baer, David G. Dubick, Michael A. Wade, Charles E. Holcomb, John B. Walters, Thomas J. TI The Effect of a Hypobaric, Hypoxic Environment on Acute Skeletal Muscle Edema after Ischemia-Reperfusion Injury in Rats SO JOURNAL OF SURGICAL RESEARCH LA English DT Article DE compartment syndrome; muscle injury; altitude; flight; air evacuation; military; extremity trauma ID OPERATION IRAQI FREEDOM; BODY-FLUID COMPARTMENTS; HIGH-ALTITUDE EXPOSURE; COMPLICATIONS; ACTIVATION; EVACUATION; CASUALTIES; RECOVERY; HUMANS; FLIGHT AB Background. Clinicians have postulated that decreased atmospheric pressure during air evacuation exacerbates muscle edema and necrosis in injured limbs. The present study investigated whether the mild hypobaric, hypoxic conditions of simulated flight during muscle reperfusion worsened muscle edema and muscle injury in an established animal model. Methods. Twenty male Sprague-Dawley rats underwent tourniquet-induced hind limb ischemia for 2 h. After removal of the tourniquet, rats were divided into two groups (n = 10/group), and exposed to either (1) hypobaric, hypoxic conditions (HB) of 522 mm Hg (simulating 10,000 feet, the upper limit of normal aircraft cabin pressure), or (2) normobaric, normoxic conditions (NB) of 760 mm Hg (sea level), for 6 h. Muscle wet weight, muscle dry:wet weight ratios, viability, and routine histology were measured on the gastrocnemius and tibialis anterior muscles. Blood samples were analyzed for percentage hematocrit, leukocyte count, and coagulation status. Results. Ischemia resulted in significant edema in both groups (P < 0.05). Normobaric normoxia caused greater edema in the gastrocnemius compared with hypobaric hypoxia; the tibialis anterior was not significantly different between groups. The decrease in body weight for NB and HB was 3.4 +/- 1.4 and 10.7 +/- 1.2 g, respectively (P < 0.05). Hematocrit was 44.7 +/- 0.5 and 42.6 +/- 0.6 (P < 0.05). Conclusions. The hypobaric, hypoxic conditions of simulated medical air evacuation were not associated with increased muscle edema following 2 h of ischemic injury. This suggests that other factors, such as resuscitation, may be the cause of muscle edema in flight-evacuated patients. Published by Elsevier Inc. C1 [Walters, Thomas J.] USA, Inst Surg Res, Regenerat Med Res Program, San Antonio, TX 78234 USA. RP Walters, TJ (reprint author), USA, Inst Surg Res, Regenerat Med Res Program, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM thomas.walters@amedd.army.mil FU U.S. Army Medical Research and Medical Command FX This study was supported by the U.S. Army Medical Research and Medical Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense (AR 360-5). NR 39 TC 5 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD MAY 15 PY 2010 VL 160 IS 2 BP 253 EP 259 DI 10.1016/j.jss.2009.03.037 PG 7 WC Surgery SC Surgery GA 590VY UT WOS:000277257600014 PM 19577258 ER PT J AU Rosati, JD Dean, RG Stone, GW AF Rosati, Julie Dean Dean, Robert G. Stone, Gregory W. TI A cross-shore model of barrier island migration over a compressible substrate SO MARINE GEOLOGY LA English DT Article DE barrier island; migration; numerical modeling; storm response; deltaic coasts; consolidation ID MORPHOLOGICAL-BEHAVIOR MODEL; MISSISSIPPI RIVER DELTA; SEA-LEVEL RISE; COASTAL CHANGE; LOUISIANA; EVOLUTION; OVERWASH; STRATIGRAPHY; RESTORATION; DESTRUCTION AB Barrier islands that overlie a compressible substrate, such as islands in deltaic environments or those that overlay mud or peat deposits, load and consolidate the underlying subsurface. Through time, the elevation and aerial extent of these islands are reduced, making them more susceptible to future inundation and overwash. Sand washed over the island and onto back-barrier marsh or into the bay or estuary begins the consolidation process on a previously non-loaded substrate, with time-dependent consolidation as a function of the magnitude of the load, duration of load, and characteristics of the substrate. The result is an increase in the overwash, migration, breaching, and segmentation of these islands. This research developed a two-dimensional (cross-shore) numerical model for evolution of a sandy barrier island that spans durations of years to decades as a function of erosion, runup, overwash, migration, and time-dependent consolidation of the underlying substrate as a function of loading by the island. The model was tested with field data and then applied to evaluate the effects of a compressible substrate on long-term barrier island evolution. Results illustrate that barrier islands overlying a compressible substrate are more likely to have reduced dune elevation due to consolidation, incur overall volumetric adjustment of the profile to fill in compressed regions outside the immediate footprint of the island, and experience increased overwash and migration when the dune reaches a critical elevation with respect to the prevalent storm conditions. Published by Elsevier B.V. C1 [Rosati, Julie Dean] USA, Corps Engineers Res & Dev Ctr, Coastal & Hydraul Lab, Mobile, AL 36628 USA. [Dean, Robert G.] Univ Florida, Coastal & Ocean Engn Dept, Gainesville, FL 32605 USA. [Stone, Gregory W.] Louisiana State Univ, Inst Coastal Studies, Baton Rouge, LA 70803 USA. [Stone, Gregory W.] Louisiana State Univ, Dept Oceanog & Coastal Sci, Baton Rouge, LA 70803 USA. RP Rosati, JD (reprint author), USA, Corps Engineers Res & Dev Ctr, Coastal & Hydraul Lab, 109 St Joseph St,POB 2288, Mobile, AL 36628 USA. EM Julie.D.Rosati@usace.army.mil FU U.S. Army Corps of Engineers; Coastal and Hydraulics Laboratory, Engineering Research and Development Center (ERDC) FX Portions of this work were funded by several programs of the U.S. Army Corps of Engineers: the Internal Research and Investment Program, the Coastal Inlets Research Program, and the System-Wide Water Resources Program, all funded through the Coastal and Hydraulics Laboratory, Engineering Research and Development Center (ERDC). NR 85 TC 3 Z9 6 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD MAY 15 PY 2010 VL 271 IS 1-2 BP 1 EP 16 DI 10.1016/j.margeo.2010.01.005 PG 16 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA 588WD UT WOS:000277104300001 ER PT J AU Chen, G Xu, ZY Sadler, BM AF Chen, Gang Xu, Zhengyuan Sadler, Brian M. TI Experimental demonstration of ultraviolet pulse broadening in short-range non-line-of-sight communication channels SO OPTICS EXPRESS LA English DT Article ID LIGHT-EMITTING-DIODES; AVALANCHE PHOTODIODES; PERFORMANCE; PROPAGATION; NETWORK; SYSTEM AB An experimental test-bed using a narrow-pulsed ultraviolet (UV) laser and high-bandwidth photomultiplier tube was set up to characterize pulse broadening effects in short-range non-line-of-sight (NLOS) scattering communication channels. Pulse broadening is reported as a function of the transmitter elevation angle, transmitter beam angle, receiver elevation angle, receiver field-of-view, and transmitter-receiver distance. The results provide insight into the channel bandwidth and achievable communication data rate. (c) 2010 Optical Society of America C1 [Chen, Gang; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA. RP Chen, G (reprint author), Univ Calif Riverside, Dept Elect Engn, 900 Univ Ave, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu FU Army Research Office [W911NF-08-1-0163, W911NF-09-1-0293]; Army Research Laboratory under the Collaborative Technology Alliance Program [DAAD19-01-2-0011] FX The authors would like to thank Kaiyun Cui, Haipeng Ding, Qunfeng He, Yiyang Li, and Leijie Wang for their invaluable help with experiments and discussions. This work was supported in part by the Army Research Office under Grants W911NF-08-1-0163 and W911NF-09-1-0293, and the Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 29 TC 38 Z9 44 U1 4 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD MAY 10 PY 2010 VL 18 IS 10 BP 10500 EP 10509 DI 10.1364/OE.18.010500 PG 10 WC Optics SC Optics GA 594TD UT WOS:000277560000075 PM 20588903 ER PT J AU Teyhen, DS Christ, TR Ballas, ER Hoppes, CW Walters, JD Christie, DS Dreitzler, G Kane, EJ AF Teyhen, Deydre S. Christ, Tansy R. Ballas, Elissa R. Hoppes, Carrie W. Walters, Joshua D. Christie, Douglas S. Dreitzler, Gail Kane, Edward J. TI Digital fluoroscopic video assessment of glenohumeral migration: Static vs. Dynamic conditions SO JOURNAL OF BIOMECHANICS LA English DT Article DE Fluoroscopy; Biomechanics; Glenohumeral joint; Subacromial space; Rotator cuff ID SUBACROMIAL SPACE WIDTH; ROTATOR CUFF; IMPINGEMENT SYNDROME; SHOULDER; MOTION; KINEMATICS; FATIGUE; HUMERUS; TEARS; JOINT AB The purpose was to compare glenohumeral (GH) migration, during dynamic shoulder elevation and statically held positions using digital fluoroscopic videos (DFV). Thirty male volunteers (25 +/- 4 years) without right shoulder pathology were analyzed using DFV (30 Hz) during arm elevation in the scapular plane. DFV were obtained at the arm at side position, 45 degrees, 90 degrees, and 135 degrees for static and dynamic conditions. GH migration was measured as the distance from the center of the humeral head migrated superiorly or inferiorly relative to the center of the glenoid fossa. Inter-rater reliability was considered good; ICC (2,3) ranged from 0.83 to 0.92. A main effect was revealed for contraction type (p=0.031), in which post-hoc t-tests revealed that humeral head was significantly more superior on the glenoid fossa during dynamic contraction. A main effect was also revealed for arm angle (p<0.001), in which post-hoc t-tests revealed significantly more superior humeral head positioning at 45 degrees, 90 degrees, and 135 degrees when compared to arm at side (p<0.001), as well as at 90 degrees compared to 45 degrees (p=0.024). There was no interaction effect between angle and contraction type (p=0.400). Research utilizing static imaging may underestimate the amount of superior GH migration that occurs dynamically. Published by Elsevier Ltd. C1 [Christ, Tansy R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Teyhen, Deydre S.; Christie, Douglas S.] Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Hoppes, Carrie W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Walters, Joshua D.] Bassett Army Community Hosp, Ft Wainwright, AK USA. [Dreitzler, Gail] USAREC, Ft Knox, KY USA. [Kane, Edward J.] Univ St Augustine, San Diego, CA USA. RP Christ, TR (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM deydre.teyhen@us.army.mil; tansy.christ@us.army.mil NR 29 TC 9 Z9 9 U1 1 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0021-9290 J9 J BIOMECH JI J. Biomech. PD MAY 7 PY 2010 VL 43 IS 7 BP 1380 EP 1385 DI 10.1016/j.jbiomech.2010.01.026 PG 6 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA 598VG UT WOS:000277866500021 PM 20199778 ER PT J AU Ye, SJ Nguyen, KT Boughton, AP Mello, CM Chen, Z AF Ye, Shuji Nguyen, Khoi Tan Boughton, Andrew P. Mello, Charlene M. Chen, Zhan TI Orientation Difference of Chemically Immobilized and Physically Adsorbed Biological Molecules on Polymers Detected at the Solid/Liquid Interfaces in Situ SO LANGMUIR LA English DT Article ID SUM-FREQUENCY GENERATION; PEPTIDE CECROPIN P1; NONLINEAR-OPTICAL SPECTROSCOPY; VIBRATIONAL SPECTROSCOPY; ANTIMICROBIAL PEPTIDES; ESCHERICHIA-COLI; POLY(METHYL METHACRYLATE); PROTEIN BIOCHIPS; LIPID-BILAYERS; SURFACE AB A surface sensitive second order nonlinear optical technique, sum frequency generation vibrational spectroscopy, was applied to study peptide orientation on polymer surfaces, supplemented by a linear vibrational spectroscopy, attenuated total reflectance Fourier transform infrared spectroscopy. Using the antimicrobial peptide Cecropin PI as a model system, we have quantitatively demonstrated that chemically immobilized peptides on polymers adopt a more ordered orientation than less tightly bound physically adsorbed peptides. These differences were also observed in different chemical environments, for example, air versus water. Although numerous studies have reported a direct correlation between the choice of immobilization method and the performance of an attached biological molecule, the lack of direct biomolecular structure and orientation data has made it difficult to elucidate the relationship between structure, orientation, and function at a surface. In this work, we directly studied the effect of chemical immobilization method on biomolecular orientation/ordering, an important step for future studies of biomolecular activity. The methods for orientation analysis described within are also of relevance to understanding biosensors, biocompatibility, marine-antifouling, membrane protein functions, and antimicrobial peptide activities. C1 [Mello, Charlene M.] USA, NSRDEC, Biosci & Technol Team, Natick, MA 01760 USA. [Ye, Shuji; Nguyen, Khoi Tan; Boughton, Andrew P.; Chen, Zhan] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA. RP Mello, CM (reprint author), USA, NSRDEC, Biosci & Technol Team, Natick, MA 01760 USA. EM Charlene.Mello@us.army.mil; zhanc@umich.edu RI Ye, Shuji/B-4479-2010; Nguyen, Khoi/B-2730-2014; Chen, Zhan/G-8312-2016; OI Nguyen, Khoi/0000-0003-3934-0371; Chen, Zhan/0000-0001-8687-8348; Boughton, Andrew/0000-0002-0318-4912 FU US Army Natick Soldier Research, Development and Engineering Center through Battelle Scientific Services Program [TCN 08-064]; National Institutes of Health [1R01GM081655-01A2] FX This research is supported by US Army Natick Soldier Research, Development and Engineering Center through Battelle Scientific Services Program (TCN 08-064) and National Institutes of Health (1R01GM081655-01A2). This manuscript has been approved for unlimited distribution by the U.S. Army Natick Soldier Research, Development and Engineering Center (PAD # U09-112). NR 85 TC 30 Z9 30 U1 3 U2 36 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAY 4 PY 2010 VL 26 IS 9 BP 6471 EP 6477 DI 10.1021/la903932w PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 587DV UT WOS:000276969700060 PM 19961170 ER PT J AU Pinzon-Arango, PA Nagarajan, R Camesano, TA AF Pinzon-Arango, Paola A. Nagarajan, Ramanathan Camesano, Terri A. TI Effects of L-Alanine and Inosine Germinants on the Elasticity of Bacillus anthracis Spores SO LANGMUIR LA English DT Article ID ATOMIC-FORCE MICROSCOPY; SUBTILIS SPORES; STRUCTURAL DYNAMICS; CELLS; ENDOSPORES; ACID; PRESSURE; BACTERIA; ADHESION; COAT AB The surface of dormant Bacillus anthracis spores consists of a multilayer of protein coats and a thick peptidoglycan layer that allow the cells to resist chemical and environmental insults. During germination, the spore coat is degraded, making the spore susceptible to chemical inactivation by antisporal agents as well as to mechanical inactivation by high-pressure or mechanical abrasion processes. While chemical changes during germination, especially the release of the germination marker, dipicolinic acid (DPA), have been extensively studied, there is as yet no investigation of the corresponding changes in the mechanical properties of the spore. In this work, we use atomic force microscopy (A FM) to characterize the mechanical properties of the surface of Bacillus anthracis spores during germination. The Hertz model of continuum mechanics of contact was used to evaluate the Young's moduli of the spores before and after germination by applying the model to load-indentation curves. The highest modulus was observed for dormant spores, with average elasticity values of 197 +/- 81 MPa. The elasticity decreased significantly after incubation of the spores with the germinants L-alanine or inosine (47.5 +/- 41.7 and 35.4 +/- 15.8 M Pa, respectively). Exposure of B. anthracis spores to a mixture of both germinants resulted in a synergistic effect with even lower elasticity, with a Young's modulus of 23.5 +/- 14.8 M Pa. The elasticity of the vegetative B. anthracis cells was nearly 15 times lower than that of the dormant spores (12.4 +/- 6.3 MPa vs 197.0 +/- 80.5 MPa, respectively). Indeed from a mechanical strength point of view, the germinated spores were closer to the vegetative cells than to the dormant spores. Further, the decrease in the elasticity of the cells was accompanied by increasing AFM tip indentation depths on the cell surfaces. Indentation depths of up to 246.2 nm were observed for vegetative B. anthracis compared to 20.5 nm for the dormant spores. These results provide quantitative information on how the mechanical properties of the cell wall change during germination, which may explain how spores become susceptible to inactivation processes based on mechanical forces during germination and outgrowth. The study of spore elasticity may be a valuable tool in the design of improved antisporal treatments. C1 [Pinzon-Arango, Paola A.; Camesano, Terri A.] Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA. [Nagarajan, Ramanathan] USA, Natick Soldier Res Dev & Engn Ctr, Mol Sci & Engn Team, Natick, MA 01760 USA. RP Camesano, TA (reprint author), Worcester Polytech Inst, Dept Chem Engn, Worcester, MA 01609 USA. EM terric@wpi.edu OI Nagarajan, Ramanathan/0000-0003-4758-2231 FU National Science Foundation [CBET 0827229]; Defence Threat Reduction Agency (DTRA) [BA07PRO102] FX This work was supported in part by the National Science Foundation (CBET 0827229) and the Defence Threat Reduction Agency (DTRA) Project BA07PRO102. We also thank Ms. Angela Tao for her assistance in the development of the MaiLab script used for elasticity measurements, Mr. Robert Stote and Ms. Stephanie Marcott of NSRDEC for help with spore preparation, and Prof. Nancy Burnham for helpful discussions. NR 37 TC 14 Z9 14 U1 0 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD MAY 4 PY 2010 VL 26 IS 9 BP 6535 EP 6541 DI 10.1021/la904071y PG 7 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 587DV UT WOS:000276969700069 PM 20095533 ER PT J AU Hood, MA Wang, BB Sands, JM La Scala, JJ Beyer, FL Li, CY AF Hood, Matthew A. Wang, Bingbing Sands, James M. La Scala, John J. Beyer, Frederick L. Li, Christopher Y. TI Morphology control of segmented polyurethanes by crystallization of hard and soft segments SO POLYMER LA English DT Article DE Segmented polyurethane; Confined crystallization; Phase separation ID MULTIPLE MELTING ENDOTHERMS; BLOCK CONTENT POLYURETHANE; HELICAL LAMELLAR CRYSTALS; STRESS-STRAIN BEHAVIOR; X-RAY-SCATTERING; POLY(URETHANE UREA); SEPARATION KINETICS; CARBON NANOTUBES; CHIRAL POLYESTER; ELASTOMERS AB Segmented polyurethanes (SPUs) have been designed with controlled hard to soft segment ratios. The confinement effect of the SPU blocks is induced by phase separation of the SPU segments and has been harnessed to selectively control crystallization. Hard segment (HS) concentrations greater than 50 wt.% allowed for the study of morphological changes and mechanical properties associated with confinement of the soft segment (SS). It was observed that crystallization temperature and normalized percent crystallinity were reduced with increasing HS content, creating a largely amorphous PEG SS at ambient temperature. High temperature annealing further confined the SS because the HS had more time to crystallize, which increased confinement. Considerable insight has been gained through the manipulation and characterization of the SS and HS, in an SPU, towards the design of impact absorbing and structural materials. (C) 2010 Elsevier Ltd. All rights reserved. C1 [Hood, Matthew A.; Wang, Bingbing; Li, Christopher Y.] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. [Sands, James M.; La Scala, John J.; Beyer, Frederick L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Li, CY (reprint author), Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA. EM chrisli@drexel.edu RI Li, Christopher/A-1603-2012 FU US Army Research Laboratory [W911NF-06-2-0013]; Department of Education FX We thank the US Army Research Laboratory for financial support under the Army Materials Center of Excellence Program (Contract W911NF-06-2-0013) and the Department of Education's GAANN DREAM Fellowship. WAXD, FTIR and TEM experiments were carried out at Drexel's Centralized Research Facility. NR 56 TC 52 Z9 52 U1 7 U2 53 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD MAY 4 PY 2010 VL 51 IS 10 BP 2191 EP 2198 DI 10.1016/j.polymer.2010.03.027 PG 8 WC Polymer Science SC Polymer Science GA 589YU UT WOS:000277190900011 ER PT J AU Romasco, AL Friedman, LH Fang, L Meirom, RA Clark, TE Polcawich, RG Pulskamp, JS Dubey, M Muhlstein, CL AF Romasco, A. L. Friedman, L. H. Fang, L. Meirom, R. A. Clark, T. E. Polcawich, R. G. Pulskamp, J. S. Dubey, M. Muhlstein, C. L. TI Deformation behavior of nanograined platinum films SO THIN SOLID FILMS LA English DT Article DE Platinum; Elastic properties; Hardness ID STRAIN-RATE SENSITIVITY; THIN-FILMS; MECHANICAL-PROPERTIES; NANOCRYSTALLINE NICKEL; NANOINDENTATION CREEP; ELASTIC-MODULUS; INDENTATION; CONTACT; METALS; SIZE AB Anomalously low elastic moduli have been routinely reported in nanoindentation studies, but it was not clear if the behavior was real or an artifact of the measurement technique. Here, we report on similarly low elastic moduli of 111 textured, nanograined platinum films. In this work the presence of anomalous properties was verified by eliminating possible sources of experimental artifacts, namely the films' texture, piling-up of material around the indenter tip, substrate effects, microcracking, and delamination of the film from the substrate. Instead, the peculiar behavior of the nanograined, noble metal film was linked to time-dependent, elastic constitutive behavior (i.e., anelasticity). (C) 2010 Elsevier B.V. All rights reserved. C1 [Romasco, A. L.; Meirom, R. A.; Muhlstein, C. L.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. [Friedman, L. H.; Fang, L.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA. [Clark, T. E.] Penn State Univ, Mat Res Inst, University Pk, PA 16802 USA. [Polcawich, R. G.; Pulskamp, J. S.; Dubey, M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Muhlstein, CL (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA. EM clm28@psu.edu RI Friedman, Lawrence/G-5650-2011 OI Friedman, Lawrence/0000-0003-2416-9903 FU U.S. Army Research Office (ARO) [48355EG, W911NF-05-1-00640]; National Science Foundation [0528234, 0335765]; Pennsylvania State University Materials Research Institute NanoFabrication Network FX The authors acknowledge the support of the U.S. Army Research Office (ARO 48355EG, W911NF-05-1-00640, program manager Dr. Bruce LaMattina) and the National Science Foundation (program No. 0528234, program manager Dr. Ken Chong). This work was also supported by the Pennsylvania State University Materials Research Institute NanoFabrication Network and the National Science Foundation Cooperative Agreement No. 0335765, National Nanotechnology Infrastructure Network, with Cornell University. The authors would also like to thank the contributions of Prashant Ranade of General Technical Services for his role in the fabrication of the platinum thin films. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of Cornell University nor those of the National Science Foundation. NR 40 TC 9 Z9 9 U1 0 U2 12 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD MAY 3 PY 2010 VL 518 IS 14 BP 3866 EP 3874 DI 10.1016/j.tsf.2010.02.007 PG 9 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA 601MT UT WOS:000278064600048 ER PT J AU Brunye, TT Mahoney, CR Taylor, HA AF Brunye, Tad T. Mahoney, Caroline R. Taylor, Holly A. TI Moving through imagined space: Mentally simulating locomotion during spatial description reading SO ACTA PSYCHOLOGICA LA English DT Article DE Mental model; Spatial memory; Reading time; Embodiment; Distance perception ID VISUOSPATIAL WORKING-MEMORY; SITUATION MODELS; NARRATIVE COMPREHENSION; LANGUAGE COMPREHENSION; VERBAL DESCRIPTIONS; SENTENCE COMPREHENSION; INDIVIDUAL-DIFFERENCES; EMBODIED COGNITION; PERSPECTIVE-TAKING; ROUTE DESCRIPTIONS AB Readers mentally simulate the perceptual and motoric elements related through text. Sound is one perceptual characteristic of these embodied simulations that has received little attention. Two experiments tested whether movement sounds (walking vs. running) or metronome pulses (fast vs. slow) would modulate reading speed and memory for two different types of spatial descriptions, route and survey. Route descriptions describe environments from a first-person, ground-level perspective whereas survey descriptions use an aerial overview perspective. Experiment 1 demonstrated that route description readers altered their reading speed in correspondence with both movement and metronome sounds, progressing through descriptions faster when hearing fast-paced versus slow-paced sounds. When reading survey descriptions, however, readers only modulated their reading speed while listening to metronome pulses. Those who showed the greatest reading time effects with the route description and footstep sounds also showed difficulty solving inferences from the survey perspective. Experiment 2 demonstrated that movement sounds influenced perceptions of distance traveled such that estimates of environmental scale increased after listening to running versus walking sounds. Taken together these results demonstrate that route description readers mentally simulate a journey through a described world, and these simulations and the resulting spatial memories can be guided by auditory information. Published by Elsevier B.V. C1 [Brunye, Tad T.] USA, NSRDEC, Attn AMSRD NSC WS P, Natick, MA 01760 USA. [Brunye, Tad T.; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA. RP Brunye, TT (reprint author), USA, NSRDEC, Attn AMSRD NSC WS P, Kansas St, Natick, MA 01760 USA. EM tbrunye@alumni.tufts.edu NR 96 TC 11 Z9 11 U1 0 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-6918 J9 ACTA PSYCHOL JI Acta Psychol. PD MAY PY 2010 VL 134 IS 1 BP 110 EP 124 DI 10.1016/j.actpsy.2010.01.003 PG 15 WC Psychology, Experimental SC Psychology GA 579LP UT WOS:000276372400013 PM 20144826 ER PT J AU Dailey, JI AF Dailey, Jason I. TI Modeling manipulation in medical education SO ADVANCES IN HEALTH SCIENCES EDUCATION LA English DT Editorial Material DE Curriculum; Medical education; Medical ethics; Professionalism; Reimbursement; Residency training ID REIMBURSEMENT RULES; INSURANCE COMPANIES; HIDDEN CURRICULUM; PHYSICIANS; DECEPTION; RESIDENTS AB As residents and medical students progress through their medical training, they are presented with multiple instances in which they feel they must manipulate the healthcare system and deceive others in order to efficiently treat their patients. This, however, creates a culture of manipulation resulting in untoward effects on trainees' ethical and professional development. Yet manipulation need not be a skill necessary to practice medicine, and steps should be taken by both individuals and institutions to combat the view that the way medicine must be practiced "in the real world" is somehow different from what one's affective moral sense implores. C1 Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96859 USA. RP Dailey, JI (reprint author), Tripler Army Med Ctr, Dept Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Jason.Dailey@amedd.army.mil NR 20 TC 1 Z9 1 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1382-4996 J9 ADV HEALTH SCI EDUC JI Adv. Health Sci. Educ. PD MAY PY 2010 VL 15 IS 2 BP 291 EP 295 DI 10.1007/s10459-008-9112-8 PG 5 WC Education & Educational Research; Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA 577EH UT WOS:000276204300011 PM 18418725 ER PT J AU Stuban, SL AF Stuban, Sandra L. TI HOME MECHANICAL VENTILATION SO AMERICAN JOURNAL OF NURSING LA English DT Editorial Material ID ORAL CARE; PNEUMONIA C1 [Stuban, Sandra L.] US Army Nurse Corps, Fairfax, VA USA. EM StubanRN@aol.com NR 8 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD MAY PY 2010 VL 110 IS 5 BP 63 EP 67 DI 10.1097/01.NAJ.0000372080.63145.13 PG 5 WC Nursing SC Nursing GA 622VR UT WOS:000279694400021 PM 20520124 ER PT J AU Clemenshaw, M Bui-Mansfield, L O'Brien, S AF Clemenshaw, M. Bui-Mansfield, L. O'Brien, S. TI "Not Just Any Tom, Dick, or Harry:" Anomalous Muscles of the Ankle, How to Recognize Them on MRI and Their Clinical Relevance SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract CT 110th Annual Meeting of the American-Roentgen-Ray-Society CY MAY 02-07, 2010 CL San Diego, CA SP Amer Roentgen Ray Soc C1 [Clemenshaw, M.; Bui-Mansfield, L.; O'Brien, S.] Brooke Army Med Ctr, San Antonio, TX USA. EM liem_mansfield@hotmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2010 VL 194 IS 5 SU S MA E393 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 586RV UT WOS:000276931000635 ER PT J AU Shogan, P Peterson, M Petermann, G Smith, A Smirniotopoulos, J AF Shogan, P. Peterson, M. Petermann, G. Smith, A. Smirniotopoulos, J. TI Brain Herniation SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract CT 110th Annual Meeting of the American-Roentgen-Ray-Society CY MAY 02-07, 2010 CL San Diego, CA SP Amer Roentgen Ray Soc C1 [Shogan, P.; Peterson, M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Petermann, G.] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI USA. [Smith, A.; Smirniotopoulos, J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. [Smith, A.; Smirniotopoulos, J.] Armed Forces Inst Pathol, Washington, DC 20306 USA. EM pshogan@yahoo.com RI Smirniotopoulos, James/D-3726-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2010 VL 194 IS 5 SU S MA E496 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 586RV UT WOS:000276931000738 ER PT J AU Shogan, P Fischer, T Long, J Frew, M Bunger, R Folio, L Provenzale, J AF Shogan, P. Fischer, T. Long, J. Frew, M. Bunger, R. Folio, L. Provenzale, J. TI Anatomic Positioning System: Accuracy of Localization of Mock Blast Fragments on CT in 3D SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract CT 110th Annual Meeting of the American-Roentgen-Ray-Society CY MAY 02-07, 2010 CL San Diego, CA SP Amer Roentgen Ray Soc C1 [Shogan, P.; Long, J.; Frew, M.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Fischer, T.; Bunger, R.; Folio, L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Provenzale, J.] Duke Univ, Med Ctr, Durham, NC USA. EM pshogan@yahoo.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2010 VL 194 IS 5 SU S MA E172 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 586RV UT WOS:000276931000418 ER PT J AU Dharnidharka, VR Cherikh, WS Neff, R Cheng, Y Abbott, KC AF Dharnidharka, V. R. Cherikh, W. S. Neff, R. Cheng, Y. Abbott, K. C. TI Retransplantation After BK Virus Nephropathy in Prior Kidney Transplant: An OPTN Database Analysis SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE BK virus; immunosuppression; infection; kidney transplantation; polyoma ID POLYOMAVIRUS TYPE BK; LONG-TERM IMMUNOSUPPRESSION; GRAFT LOSS; MAINTENANCE PREDNISONE; RECIPIENTS; REPLICATION; REGISTRY; VIREMIA AB BK virus (BKV) has emerged as a major complication of kidney transplantation. Since June 30, 2004, the OPTN in the USA collects BKV as a primary or secondary cause of graft loss and also if treatment for BK virus (TBKV) is administered. In this study, we determined characteristics of those recipients of repeat kidney transplants from the OPTN database, where either (a) a graft loss occurred between June 30, 2004 and December 31, 2008 and database recorded prior TBKV in that allograft or (b) a graft loss between June 30, 2004 and December 31, 2008 was attributed primarily or secondarily due to BKV. In the study time period, 823 graft losses have occurred where TBKV or graft failure attributable to BKV was reported in prior transplant; of these, 126 have received a retransplant as of June 5, 2009. Induction and maintenance immunosuppression usage mirrored current trends. As of June 5, 2009, 118/126 grafts are still functioning, one graft failure attributed to BKV. TBKV was reported in 17.5% of the retransplants. In the retransplants performed through December 31, 2007, 1-year acute rejection rate was 7%, 1-year and 3-year Kaplan-Meier graft survival rates and median GFR were 98.5%, 93.6%, 65.5 and 68.4 mL/min, respectively. Retransplantation after BKV appears to be associated with good results. C1 [Dharnidharka, V. R.] Univ Florida, Coll Med, Dept Pediat, Shands Childrens Hosp, Gainesville, FL 32611 USA. [Cherikh, W. S.; Cheng, Y.] United Network Organ Sharing, Res Dept, Richmond, VA USA. [Neff, R.; Abbott, K. C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. RP Dharnidharka, VR (reprint author), Univ Florida, Coll Med, Dept Pediat, Shands Childrens Hosp, Gainesville, FL 32611 USA. EM vikasmd@peds.ulf.edu NR 19 TC 25 Z9 28 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAY PY 2010 VL 10 IS 5 BP 1312 EP 1315 DI 10.1111/j.1600-6143.2010.03083.x PG 4 WC Surgery; Transplantation SC Surgery; Transplantation GA 586OZ UT WOS:000276921600028 PM 20353461 ER PT J AU Trombley, AR Wachter, L Garrison, J Buckley-Beason, VA Jahrling, J Hensley, LE Schoepp, RJ Norwood, DA Goba, A Fair, JN Kulesh, DA AF Trombley, Adrienne R. Wachter, Leslie Garrison, Jeffrey Buckley-Beason, Valerie A. Jahrling, Jordan Hensley, Lisa E. Schoepp, Randal J. Norwood, David A. Goba, Augustine Fair, Joseph N. Kulesh, David A. TI Short Report: Comprehensive Panel of Real-Time TaqMan (TM) Polymerase Chain Reaction Assays for Detection and Absolute Quantification of Filoviruses, Arenaviruses, and New World Hantaviruses SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID REVERSE TRANSCRIPTION-PCR; FLUOROGENIC 5'-NUCLEASE ASSAY; HEMORRHAGIC-FEVER; LASSA FEVER; RAPID DETECTION; PUUMALA-HANTAVIRUS; VIRUS-INFECTION; DIAGNOSIS; EBOLA; SAMPLES AB Viral hemorrhagic fever is caused by a diverse group of single-stranded, negative-sense or positive-sense RNA viruses belonging to the families Filoviridae (Ebola and Marburg), Arenaviridae (Lassa, Junin, Machupo, Sabia, and Guanarito), and Bunyaviridae (hantavirus). Disease characteristics in these families mark each with the potential to be used as a biological threat agent. Because other diseases have similar clinical symptoms, specific laboratory diagnostic tests are necessary to provide the differential diagnosis during outbreaks and for instituting acceptable quarantine procedures. We designed 48 TaqMan (TM)-based polymerase chain reaction (PCR) assays for specific and absolute quantitative detection of multiple hemorrhagic fever viruses. Forty-six assays were determined to be virus-specific, and two were designated as pan assays for Marburg virus. The limit of detection for the assays ranged from 10 to 0.001 plaque-forming units (PFU)/PCR. Although these real-time hemorrhagic fever virus assays are qualitative (presence of target), they are also quantitative (measure a single DNA/RNA target sequence in an unknown sample and express the final results as an absolute value (e.g., viral load. PFUs, or copies/mL) on the basis of concentration of standard samples and can be used in viral load, vaccine, and antiviral drug studies. C1 [Trombley, Adrienne R.; Schoepp, Randal J.; Norwood, David A.; Kulesh, David A.] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. [Garrison, Jeffrey] Battelle Mem Inst, Columbus, OH USA. [Wachter, Leslie] Medimmune Inc, Gaithersburg, MD 20878 USA. [Jahrling, Jordan] Univ Texas Med Branch, Dept Neurosci, Galveston, TX USA. [Goba, Augustine] Kenema Govt Hosp, Lassa Fever Lab, Kenema, Sierra Leone. [Fair, Joseph N.] Global Viral Forecasting Initiat, San Francisco, CA USA. RP Kulesh, DA (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. EM David.Kulesh@us.army.mil FU Defense Threat Reduction Agency FX This study was supported by the Defense Threat Reduction Agency, project ID no. 8.10007_05_RD_B. NR 24 TC 88 Z9 90 U1 0 U2 9 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 2010 VL 82 IS 5 BP 954 EP 960 DI 10.4269/ajtmh.2010.09-0636 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 592UQ UT WOS:000277406500033 PM 20439981 ER PT J AU Gertsch, JC Noblitt, SD Cropek, DM Henry, CS AF Gertsch, Jana C. Noblitt, Scott D. Cropek, Donald M. Henry, Charles S. TI Rapid Analysis of Perchlorate in Drinking Water at Parts per Billion Levels Using Microchip Electrophoresis SO ANALYTICAL CHEMISTRY LA English DT Article ID SULFONATE ZWITTERIONIC SURFACTANTS; TANDEM MASS-SPECTROMETRY; CAPILLARY-ELECTROPHORESIS; ION CHROMATOGRAPHY; ELECTROOSMOTIC FLOW; INORGANIC ANIONS; SELECTIVITY; MOBILITY; SAMPLES; POLY(DIMETHYLSILOXANE) AB A microchip capillary electrophoresis (MCE) system has been developed for the determination of perchlorate in drinking water. The United States Environmental Protection Agency (USEPA) recently proposed a health advisory limit for perchlorate in drinking water of 15 parts per billion (ppb), a level requiring large, sophisticated instrumentation, such as ion chromatography coupled with mass spectrometry (IC-MS), for detection. An inexpensive, portable system is desired for routine online monitoring applications of perchlorate in drinking water. Here, we present an MCE method using contact conductivity detection for perchlorate determination. The method has several advantages, including reduced analysis times relative to IC, inherent portability, high selectivity, and minimal sample pretreatment. Resolution of perchlorate from more abundant ions was achieved using zwitterionic, sulfobetaine surfactants, N-hexadecyl-N,N-dimethyl-3-ammonio-1-propane sulfonate (HDAPS) and N-tetradecyl-N,N-dimethyl-3-ammonio-1-propane sulfonate (TDAPS). The system performance and the optimization of the separation chemistry, including the use of these surfactants to resolve perchlorate from other anions, are discussed in this work. The system is capable of detection limits of 3.4 +/- 1.8 ppb (n = 6) in standards and 5.6 +/- 1.7 ppb (n = 6) in drinking water. C1 [Gertsch, Jana C.; Noblitt, Scott D.; Henry, Charles S.] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. [Cropek, Donald M.] USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61824 USA. RP Henry, CS (reprint author), Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA. OI Henry, Charles/0000-0002-8671-7728 NR 37 TC 17 Z9 18 U1 0 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD MAY 1 PY 2010 VL 82 IS 9 BP 3426 EP 3429 DI 10.1021/ac9029086 PG 4 WC Chemistry, Analytical SC Chemistry GA 590GO UT WOS:000277213400008 PM 20334437 ER PT J AU Gill, SC Rubino, CM Bassett, J Miller, L Ambrose, PG Bhavnani, SM Beaudry, A Li, JF Stone, KC Critchley, I Janjic, N Heine, HS AF Gill, Stanley C. Rubino, Christopher M. Bassett, Jennifer Miller, Lynda Ambrose, Paul G. Bhavnani, Sujata M. Beaudry, Amber Li, Jinfang Stone, Kimberly Clawson Critchley, Ian Janjic, Nebojsa Heine, Henry S. TI Pharmacokinetic-Pharmacodynamic Assessment of Faropenem in a Lethal Murine Bacillus anthracis Inhalation Postexposure Prophylaxis Model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CEFUROXIME AXETIL; SINUSITIS; EFFICACY; STRAIN AB There are few options for prophylaxis after exposure to Bacillus anthracis, especially in children and women of childbearing potential. Faropenem is a beta-lactam in the penem subclass that is being developed as an oral prodrug, faropenem medoxomil, for the treatment of respiratory tract infections. Faropenem was shown to have in vitro activity against B. anthracis strains that variably express the bla1 beta-lactamase (MIC range, <= 0.06 to 1 mu g/ml). In this study we evaluated the pharmacokinetic-pharmacodynamic (PK-PD) relationships between the plasma faropenem free-drug (f) concentrations and efficacy against B. anthracis in a murine postexposure prophylaxis inhalation model. The plasma PKs and PKs-PDs of faropenem were evaluated in BALB/c mice following the intraperitoneal (i. p.) administration of doses ranging from 2.5 to 160 mg/kg of body weight. For the evaluation of efficacy, mice received by inhalation aerosol doses of B. anthracis (Ames strain; faropenem MIC, 0.06 mu g/ml) at 100 times the 50% lethal dose. The faropenem dosing regimens (10, 20, 40, and 80 mg/kg/day) were administered i. p. at 24 h postchallenge at 4-, 6-, and 12-h intervals for 14 days. The sigmoid maximum-threshold-of-efficacy (E(max)) model fit the survival data, in which the free-drug area under the concentration-time curve (fAUC)/MIC ratio, the maximum concentration of free drug in plasma (fC(max))/MIC ratio, and the cumulative percentage of a 24-h period that the free-drug concentration exceeds the MIC under steady-state pharmacokinetic conditions (f%T(MIC)) were each evaluated. Assessment of f%T(MIC) demonstrated the strongest correlation with survival (R(2) = 0.967) compared to the correlations achieved by assessment of fAUC/MIC or fC(max)/MIC, for which minimal correlations were observed. The 50% effective dose (ED(50)), ED(90), and ED(99) corresponded to f%T(MIC) values of 10.6, 13.4, and 16.4%, respectively, and E(max) was 89.3%. Overall, faropenem demonstrated a high level of activity against B. anthracis in the murine postexposure prophylaxis inhalation model. C1 [Gill, Stanley C.; Beaudry, Amber; Li, Jinfang; Stone, Kimberly Clawson; Critchley, Ian; Janjic, Nebojsa] Replidyne Inc, Dept Pharmacol, Louisville, CO USA. [Rubino, Christopher M.; Ambrose, Paul G.; Bhavnani, Sujata M.] Ordway Res Inst, Inst Clin Pharmacodynam, Albany, NY USA. [Bassett, Jennifer; Miller, Lynda; Heine, Henry S.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Gill, SC (reprint author), OSI Pharmaceut, 2960 Wilderness Pl, Boulder, CO 80027 USA. EM SGill@OSIP.com NR 17 TC 3 Z9 3 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 2010 VL 54 IS 5 BP 1678 EP 1683 DI 10.1128/AAC.00737-08 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 585DK UT WOS:000276804300004 PM 20145081 ER PT J AU Warren, TK Warfield, KL Wells, J Enterlein, S Smith, M Ruthel, G Yunus, AS Kinch, MS Goldblatt, M Aman, MJ Bavari, S AF Warren, Travis K. Warfield, Kelly L. Wells, Jay Enterlein, Sven Smith, Mark Ruthel, Gordon Yunus, Abdul S. Kinch, Michael S. Goldblatt, Michael Aman, M. Javad Bavari, Sina TI Antiviral Activity of a Small-Molecule Inhibitor of Filovirus Infection SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID EBOLA-VIRUS INFECTION; MARBURG HEMORRHAGIC-FEVER; MOUSE MODEL; MICE; TSG101; PATHOGENESIS; INVOLVEMENT; VP40 AB There exists an urgent need to develop licensed drugs and vaccines for the treatment or prevention of filovirus infections. FGI-103 is a low-molecular-weight compound that was discovered through an in vitro screening assay utilizing a variant of Zaire ebolavirus (ZEBOV) that expresses green fluorescent protein. In vitro analyses demonstrated that FGI-103 also exhibits antiviral activity against wild-type ZEBOV and Sudan ebolavirus, as well as Marburgvirus (MARV) strains Ci67 and Ravn. In vivo administration of FGI-103 as a single intraperitoneal dose of 10 mg/kg delivered 24 h after infection is sufficient to completely protect mice against a lethal challenge with a mouse-adapted strain of either ZEBOV or MARV-Ravn. In a murine model of ZEBOV infection, delivery of FGI-103 reduces viremia and the viral burden in kidney, liver, and spleen tissues and is associated with subdued and delayed proinflammatory cytokine responses and tissue pathology. Taken together, these results identify a promising antiviral therapeutic candidate for the treatment of filovirus infections. C1 [Warren, Travis K.; Warfield, Kelly L.; Wells, Jay; Smith, Mark; Ruthel, Gordon; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Enterlein, Sven; Aman, M. Javad] Integrated BioTherapeut Inc, Germantown, MD USA. [Yunus, Abdul S.; Kinch, Michael S.; Goldblatt, Michael] Funct Genet Inc, Gaithersburg, MD USA. RP Kinch, MS (reprint author), 708 Quince Orchard Rd, Gaithersburg, MD 20882 USA. EM mkinch@functional-genetics.com; sina.bavari@us.army.mil OI Kinch, Michael/0000-0003-3939-3756 FU Defense Threat Reduction Agency [HDTRA1-07-C-0080, 4.10039_07_RD_B]; Medical Research and Material Command FX The research described herein was sponsored by the Transformation Medical Technologies Initiative of the Defense Threat Reduction Agency (contracts HDTRA1-07-C-0080 and 4.10039_07_RD_B) and the Medical Research and Material Command. NR 24 TC 44 Z9 48 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 EI 1098-6596 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD MAY PY 2010 VL 54 IS 5 BP 2152 EP 2159 DI 10.1128/AAC.01315-09 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 585DK UT WOS:000276804300061 PM 20211898 ER PT J AU Rastogi, VK Ryan, SP Wallace, L Smith, LS Shah, SS Martin, GB AF Rastogi, Vipin K. Ryan, Shawn P. Wallace, Lalena Smith, Lisa S. Shah, Saumil S. Martin, G. Blair TI Systematic Evaluation of the Efficacy of Chlorine Dioxide in Decontamination of Building Interior Surfaces Contaminated with Anthrax Spores SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID BACILLUS-THURINGIENSIS SPORES; GAS; SANITIZER; CEREUS; STEEL; VAPOR AB Efficacy of chlorine dioxide (CD) gas generated by two distinct generation systems, Sabre (wet system with gas generated in water) and ClorDiSys (dry system with gas generated in air), was evaluated for inactivation of Bacillus anthracis spores on six building interior surfaces. The six building materials included carpet, acoustic ceiling tile, unpainted cinder block, painted I-beam steel, painted wallboard, and unpainted pinewood. There was no statistically significant difference in the data due to the CD generation technology at a 95% confidence level. Note that a common method of CD gas measurement was used for both wet and dry CD generation types. Doses generated by combinations of different concentrations of CD gas (500, 1,000, 1,500, or 3,000 parts per million of volume [ppmv]) and exposure times (ranging between 0.5 and 12 h) were used to evaluate the relative role of fumigant exposure period and total dose in the decontamination of building surfaces. The results showed that the time required to achieve at least a 6-log reduction in viable spores is clearly a function of the material type on which the spores are inoculated. The wood and cinder block coupons required a longer exposure time to achieve a 6-log reduction. The only material showing a clear statistical difference in rate of decay of viable spores as a function of concentration was cinder block. For all other materials, the profile of spore kill (i.e., change in number of viable spores with exposure time) was not dependent upon fumigant concentration (500 to 3,000 ppmv). The CD dose required for complete spore kill on biological indicators (typically, 1E6 spores of Bacillus atrophaeus on stainless steel) was significantly less than that required for decontamination of most of the building materials tested. C1 [Rastogi, Vipin K.; Wallace, Lalena; Smith, Lisa S.; Shah, Saumil S.] USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Ryan, Shawn P.] US EPA, Off Res & Dev, Natl Homeland Secur Res Ctr, Res Triangle Pk, NC 27711 USA. [Martin, G. Blair] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Res Triangle Pk, NC 27711 USA. RP Rastogi, VK (reprint author), USA, Res & Technol Directorate, Edgewood Chem Biol Ctr, E-3400 Kingscreek St N, Aberdeen Proving Ground, MD 21010 USA. EM vipin.rastogi@us.army.mil RI Wallace, Lance/K-7264-2013 FU U.S. Environmental Protection Agency, through its Office of Research and Development FX The U.S. Environmental Protection Agency, through its Office of Research and Development, funded and collaborated with the Department of the Army, Edgewood Chemical Biological Center, in the research described herein under Interagency Agreement DW-21-93991701. It has been subject to an administrative review but does not necessarily reflect the views of the Agency. No official endorsement should be inferred. EPA does not endorse the purchase or sale of any commercial products or services. NR 28 TC 17 Z9 19 U1 0 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 EI 1098-5336 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD MAY PY 2010 VL 76 IS 10 BP 3343 EP 3351 DI 10.1128/AEM.02668-09 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 592OF UT WOS:000277388200031 PM 20305025 ER PT J AU Webb, HE McMinn, DR Garten, RS Beckman, JL Kamimori, GH Acevedo, EO AF Webb, Heather E. McMinn, David R. Garten, Ryan S. Beckman, Jamie L. Kamimori, Gary H. Acevedo, Edmund O. TI Cardiorespiratory responses of firefighters to a computerized fire strategies and tactics drill during physical activity SO APPLIED ERGONOMICS LA English DT Article DE Stress; Occupational stress; Psychophysiology; Dual stress; Combined stress ID HEART-RATE; MENTAL CHALLENGE; EXERCISE; STRESS; FIGHTERS; DEMANDS; MORTALITY; DISEASE; DEATHS; POLICE AB Firefighters are subjected to a combination of physical and mental challenges in the course of their occupational responsibilities. However, due to the ecological factors involved with firefighting, it makes it extremely difficult to examine physiological and psychological changes that occur as a result of these combined challenges. The purpose of this study was to examine the efficacy of a computer-based Fire Strategies and Tactics Drill (FSTD) in eliciting psychological and physiological measures of stress in professional firefighters. in one session, participants exercised at 60% VO(2max) for 37 min (exercise alone condition, EAC), and in the other session the firefighter exercised for an equal amount of time and responded to the FSTD (dual challenge condition; DCC) while exercising. Cardiorespiratory (heart rate [HR], respiration rate [RR], minute ventilation [V(E)], oxygen consumption [VO(2)], ventilatory efficiency [V(E)/VO(2)], and respiratory exchange ratio [RER]) and psychometric measures (State Anxiety Inventory [SAI] and Ratings of Perceived Exertion [RPE]) were obtained throughout the experimental protocols. The NASA Task Load Index was used to assess perceived physical and mental load during each condition. The results demonstrated that the participants perceived overall workload to be higher in the DCC. Repeated measures ANOVAs revealed no differences between the EAC and DCC for VO(2) or RER, but the DCC did elicit significantly greater elevations in HR, RR, VE, and V(E)/VO(2) compared to the EAC. These results suggest that the FSTD utilized in this study provides an effective method for examining the physiological and psychological responses of firefighters in a research laboratory environment. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Webb, Heather E.; McMinn, David R.; Garten, Ryan S.; Beckman, Jamie L.; Acevedo, Edmund O.] Univ Mississippi, Dept Hlth Exercise Sci & Recreat Management, University, MS 38655 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Webb, HE (reprint author), Mississippi State Univ, Dept Kinesiol, 121 McCarthy Gymnasium, Mississippi State, MS 39762 USA. EM hwebb@colled.msstate.edu RI Webb, Heather/A-4219-2010 OI Webb, Heather/0000-0002-3925-9613 FU Mississippi Functional Genomics Network (Department of Health and Human Services/National Institutes of Health/National Center for Research Resources [P20RR0167475-03] FX This work was supported by the Mississippi Functional Genomics Network (Department of Health and Human Services/National Institutes of Health/National Center for Research Resources grant # P20RR0167475-03). NR 33 TC 16 Z9 16 U1 1 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-6870 J9 APPL ERGON JI Appl. Ergon. PD MAY PY 2010 VL 41 IS 3 BP 376 EP 381 DI 10.1016/j.apergo.2009.08.003 PG 6 WC Engineering, Industrial; Ergonomics; Psychology, Applied SC Engineering; Psychology GA 566AC UT WOS:000275340700007 PM 19793579 ER PT J AU Alvey, DC Morton, K Harmon, RS Gottfried, JL Remus, JJ Collins, LM Wise, MA AF Alvey, Daniel C. Morton, Kenneth Harmon, Russell S. Gottfried, Jennifer L. Remus, Jeremiah J. Collins, Leslie M. Wise, Michael A. TI Laser-induced breakdown spectroscopy-based geochemical fingerprinting for the rapid analysis and discrimination of minerals: the example of garnet SO APPLIED OPTICS LA English DT Article ID SENSOR TECHNOLOGY; REAL-TIME; GROSSULARITE; COLOR AB Laser-induced breakdown spectroscopy (LIBS) is an analytical technique real-time geochemical analysis that is being developed for portable use outside of the laboratory. In this study, statistical signal processing and classification techniques were applied to single-shot, broadband LIBS spectra, comprising measured plasma light intensities between 200 and 960 nm, for a suite of 157 garnets of different composition from 92 locations worldwide. Partial least squares discriminant analysis was applied to sets of 25 LIBS spectra for each garnet sample and used to classify the garnet samples based on composition and geographic origin. Careful consideration was given to the cross-validation procedure to ensure that the classification algorithm is robust to unseen data. The results indicate that broadband LIBS analysis can be used to discriminate garnets of different composition and has the potential to discern geographic origin. (C) 2010 C1 [Harmon, Russell S.] USA, Res Lab, Army Res Off, Durham, NC 27703 USA. [Alvey, Daniel C.] US Mil Acad, West Point, NY 10996 USA. [Morton, Kenneth; Remus, Jeremiah J.; Collins, Leslie M.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. [Gottfried, Jennifer L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Wise, Michael A.] Smithsonian Inst, Dept Mineral Sci, Washington, DC 20013 USA. RP Harmon, RS (reprint author), USA, Res Lab, Army Res Off, Durham, NC 27703 USA. EM russell.harmon@us.army.mil RI Gottfried, Jennifer/G-6333-2010 FU Argonne National Laboratory; ARL FX The analytical work reported here was undertaken by senior author D. Alvey as part of a U.S. Military Academy cadet summer research project with the US Army Research Laboratory (ARL), supported by the Argonne National Laboratory undergraduate student summer program. The signal processing and classification work was conducted in the SPACISS laboratory at Duke University. Additional support was provided by an ARL Fellow stipend to R. Harmon. NR 27 TC 33 Z9 35 U1 2 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAY 1 PY 2010 VL 49 IS 13 BP C168 EP C180 DI 10.1364/AO.49.00C168 PG 13 WC Optics SC Optics GA 590HZ UT WOS:000277217400042 ER PT J AU Remus, JJ Gottfried, JL Harmon, RS Draucker, A Baron, D Yohe, R AF Remus, Jeremiah J. Gottfried, Jennifer L. Harmon, Russell S. Draucker, Anne Baron, Dirk Yohe, Robert TI Archaeological applications of laser-induced breakdown spectroscopy: an example from the Coso Volcanic Field, California, using advanced statistical signal processing analysis SO APPLIED OPTICS LA English DT Article ID NEW-MEXICO OBSIDIANS; INYO-COUNTY; SUBSOURCES AB Over the past quarter century, multielement chemical analysis has become a common means for attributing the provenance of archaeological materials. The Coso Volcanic Field (CVF) in California, USA, contains at least 38 high-silica rhyolite domes, many of which contain obsidian glass that has been quarried for tools by the indigenous population for more than 12,000 years. Artifacts made from CVF obsidian are found throughout the southwestern United States and geochemical sourcing of CVF obsidian has been an important tool in understanding prehistoric Native American trading patterns. Laser-induced breakdown spectroscopy (LIBS) is a simple atomic emission spectroscopic technique that has the potential for real-time man-portable chemical analysis in the field. Because LIBS is simultaneously sensitive to all elements, a single laser shot can be used to record the broadband emission spectra, which provides a "chemical fingerprint" of a material. Single-shot broadband LIBS spectra were collected using a commercial benchtop LIBS system for 27 obsidian samples from major sites across the CVF and four additional sites in California and western Nevada outside of CVF. Classification of the samples was performed using partial least-squares discriminant analysis(PLSDA), a common chemometric technique suitable for performing regression on high-dimensional data. Provenance identification for the obsidian samples was evaluated for three separate labeling frameworks. The first framework consisted of a binary classification problem to distinguish CVF samples from non-CVF samples. The second approach focused on the CVF samples with labels that corresponded to the eight separate Coso sites encompassed by the 27 samples. In the third analysis, non-CVF samples were excluded, and the remaining 27 CVF samples were labeled based on groupings defined from previous major and trace element chemical studies, which reduces the number of possible classes from eight to four. Different aspects of the classifier setup considered in this study include the training/testing routine (a 27-fold leave-one-sample-out setup versus a simple split of the data into separate sets for training and evaluation), the number of latent variables used in the regression model, and whether PLSDA operating on the entire broadband LIBS spectrum is superior to that using only a selected subset of LIBS emission lines. The results point to the robustness of the PLSDA technique and suggest that LIBS analysis combined with the appropriate statistical signal processing has the potential to be a useful tool for chemical analysis of archaeological artifacts and geological specimens. (C) 2010 Optical Society of America C1 [Harmon, Russell S.] ARL Army Res Off, Res Triangle Pk, NC 27709 USA. [Remus, Jeremiah J.] Clarkson Univ, Dept Elect & Comp Engn, Potsdam, NY 13699 USA. [Gottfried, Jennifer L.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Draucker, Anne; Baron, Dirk; Yohe, Robert] Calif State Univ, Dept Phys & Geol, Bakersfield, CA 93311 USA. RP Harmon, RS (reprint author), ARL Army Res Off, POB 12211, Res Triangle Pk, NC 27709 USA. EM harmon@us.army.mil RI Gottfried, Jennifer/G-6333-2010 NR 29 TC 21 Z9 21 U1 1 U2 12 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAY 1 PY 2010 VL 49 IS 13 BP C120 EP C131 DI 10.1364/AO.49.00C120 PG 12 WC Optics SC Optics GA 590HZ UT WOS:000277217400037 ER PT J AU Smith, DL Liou, JCP AF Smith, David L. Liou, Jim C. P. TI Critical shear stress of trout feed and implications for particulate transport in flow through raceways SO AQUACULTURAL ENGINEERING LA English DT Article DE Shear stress; Sediment; Aquaculture; Raceways; Particles ID REDUCING PHOSPHORUS DISCHARGE; OPEN-CHANNEL FLOW; SEDIMENT ERODIBILITY; EFFLUENT TREATMENT; SUSPENDED-SOLIDS; RESUSPENSION; TURBULENCE; SYSTEMS; BED; IMPACT AB Aquaculture has been identified with many different types of environmental impacts. Of these, aquacultural sediments are noteworthy because of the associated nutrient and particulate transport from aquaculture facilities to the receiving waters. We investigated the critical shear stress needed to initiate sediment transport as a function of, bed roughness (smooth, 0.4 and 0.7 mm) and particle size (2.5, 1.4 and 0.71 mm). We estimated bed shear stress using logarithmic velocity profiles and near-bed velocity gradients and obtained a critical shear stress estimate with a relative error of 18.9% or 0.007 N/m(2). Critical shear stress estimates were impacted by particle size and bed roughness with smaller particles and greater roughness associated with greater critical shear stress. The maximum (plus uncertainty) critical shear stress for all test conditions was 0.083 N/m(2). The estimate is in agreement with other estimates of critical shear stress for aquacultural particles, and is greater than estimated available shear stress in typical Idaho raceways especially considering the algae growth in many raceways. Lack of adequate sediment transport increases the time that particles reside in the raceway which, in turn, increases mechanical and biological degradation, resulting in reduced effectiveness of sediment and nutrient management. Means to increase the critical shear stress offers opportunities for future reductions in nutrient and particle export from aquaculture operations. Published by Elsevier B.V. C1 [Smith, David L.; Liou, Jim C. P.] Univ Idaho, Dept Civil Engn, Moscow, ID 83843 USA. RP Smith, DL (reprint author), USA, Engineer Res & Dev Ctr, Water Qual & Contaminant Modeling Grp, Team CEERD EP W, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM david.l.smith@usace.army.mil; liou@uidaho.edu FU Washington State University/University of Idaho Aquaculture Initiative FX We acknowledge the Washington State University/University of Idaho Aquaculture Initiative for funding. Don L. Parks and Russ Lodge assisted with the development of experimental apparatus and collection of data. NR 46 TC 1 Z9 1 U1 1 U2 6 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0144-8609 J9 AQUACULT ENG JI Aquac. Eng. PD MAY PY 2010 VL 42 IS 3 BP 112 EP 120 DI 10.1016/j.aquaeng.2009.12.006 PG 9 WC Agricultural Engineering; Fisheries SC Agriculture; Fisheries GA 583YI UT WOS:000276716100002 ER PT J AU Bazar, MA Quinn, MJ Mozzachio, K Bleiler, JA Archer, CR Phillips, CT Johnson, MS AF Bazar, Matthew A. Quinn, Michael J., Jr. Mozzachio, Kristie Bleiler, John A. Archer, Christine R. Phillips, Carlton T. Johnson, Mark S. TI Toxicological Responses of Red-Backed Salamander (Plethodon cinereus) Exposed to Aged and Amended Soils Containing Lead SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID SHOOTING RANGE; CONTAMINATED SEDIMENT; BULLETS; SPECIATION; EXPOSURES; PH AB The use of lead in military and civilian small arms projectiles is widely acknowledged to have resulted in high soil lead concentrations at many small arms ranges. These ranges are often adjacent to wildlife habitat or have become habitat when no longer used. To assess the potential toxicity of lead to terrestrial amphibians in contaminated areas, we exposed 100 red-backed salamanders (Plethodon cinereus) to either a control soil or one of four soil treatments amended with lead acetate for 28 days. Analytical mean soil concentrations were 14 (control), 553, 1700, 4700, and 9167 mg Pb/kg soil dry weight. An additional 60 salamanders were also exposed for 28 days to one of six field-collected soil samples from a small arms range and a skeet range. The field soil concentrations ranged from 11 (background) to 16,967 mg Pb/kg soil dry weight. Food consisted of uncontaminated flightless Drosophila melanogaster. Salamander survival was reduced in amended soil treatments of 4700 and 9167 mg/kg by 15% and 80%, respectively. Inappetence was observed at 4700 and 9167 mg/kg and growth decreased in the 9167 mg/kg treatment. Total white blood cells decreased 32% at 4700 mg/kg compared to controls and were 22% lower in the 9167 mg/kg treatment. In contrast, survival was 100% for all field-collected soils with no hematological effects. At 16,967 mg/kg there was evidence of soil avoidance and decreased growth. These data suggest marked differences in toxicity and bioavailability of the lead-amended soil in contrast to the field-collected soil containing lead. C1 [Bazar, Matthew A.; Quinn, Michael J., Jr.; Johnson, Mark S.] USA, Tox Evaluat Program, Directorate Toxicol, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. [Mozzachio, Kristie] Biotechnics Inc, Hillsborough, NC 27278 USA. [Bleiler, John A.; Archer, Christine R.] ENSR Corp, Westford, MA 01886 USA. [Phillips, Carlton T.] Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bazar, MA (reprint author), USA, Tox Evaluat Program, Directorate Toxicol, Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd,ATTN MCHB TS TTE, Aberdeen Proving Ground, MD 21010 USA. EM Matthew.Bazar@us.army.mil FU Environmental Security Technology Certification Program (ESTCP) [ER 0514] FX We thank the entire team on ER 0514, namely, Doris (Andy) Anders, David Barclift, Amy Hawkins, John Noles, and David Pillard. We thank Larry R. Williams for assistance with the BMD calculation. This work was funded by the Environmental Security Technology Certification Program (ESTCP ER 0514). The views expressed in this paper are those of the authors and do not necessarily reflect the views and policies of the U. S. Army. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. NR 31 TC 2 Z9 2 U1 2 U2 15 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD MAY PY 2010 VL 58 IS 4 BP 1040 EP 1047 DI 10.1007/s00244-010-9471-z PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 589GU UT WOS:000277135900017 PM 20135309 ER PT J AU Haugen, BD Scambos, TA Pfeffer, WT Anderson, RS AF Haugen, Benjamin D. Scambos, Ted A. Pfeffer, W. Tad Anderson, Robert S. TI Twentieth-century Changes in the Thickness and Extent of Arapaho Glacier, Front Range, Colorado SO ARCTIC ANTARCTIC AND ALPINE RESEARCH LA English DT Article AB Changes in Arapaho Glacier, Front Range, Colorado, are determined using historical maps, aerial photography, and field surveys using ground penetrating radar (GPR) and Global Positioning System data. Arapaho Glacier lost 52% of its area during the 20th century, decreasing from 0.34 to 0.16 km(2). Between 1900 and 1999 glacial area loss rates increased from an average of 1500 m(2) yr(-1) to 2400 m(2) yr(-1). Average glacial thinning between 1900 and 1960 was 0.76 m yr(-1), but slowed to 0.10 m yr(-1) between 1960 and 2005. Its maximum thickness is approximately 15 m. If recent trends in area loss continue, Arapaho Glacier may disappear in as few as 65 years. However, the decline in thinning rate suggests that the glacier is retreating into a corner of its upper cirque in which increased inputs of snow from direct precipitation and avalanching, and decreased insolation will greatly slow its rate of retreat. This may be generally true for many temperate-latitude cirque glaciers. C1 [Haugen, Benjamin D.; Anderson, Robert S.] Univ Colorado, Dept Geol Sci, Boulder, CO 80309 USA. [Pfeffer, W. Tad; Anderson, Robert S.] Univ Colorado, Inst Arctic & Alpine Res, Boulder, CO 80309 USA. [Pfeffer, W. Tad] Univ Colorado, Dept Civil Environm & Architectural Engn, Boulder, CO 80309 USA. [Scambos, Ted A.] Univ Colorado, Natl Snow & Ice Data Ctr, Boulder, CO 80309 USA. RP Haugen, BD (reprint author), USA, ERDC, GSL, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM benjamin.d.haugen@usace.army.mil FU University of Colorado at Boulder; Boulder Creek Critical Zone Observatory (BcCZO) FX The authors would like to thank the many contributors to this study from the National Snow and Ice Data Center (NSIDC) and the Institute of Arctic and Alpine Research (INSTAAR) at the University of Colorado at Boulder: Rob Bauer, Terry Haran, Chandler Engel, Andy Mahoney, Peter Gibbons, Stephanie Renfrow, David Fanning, and Molly McAllister. B. D. Haugen would like to extend special thanks to Rob Roscow and Winston Voigt for their labor and assistance, as well as to Jason Neff at the University of Colorado Department of Geological Sciences and Alan Townsend at INSTAAR for their review of an early version of this manuscript. This study was supported in part by the Undergraduate Research Opportunities Program (UROP) at the University of Colorado at Boulder. The authors acknowledge the aid of the National Center for Airborne Laser Mapping for generation of the high quality 2005 DEM. R. S. Anderson acknowledges support from the Boulder Creek Critical Zone Observatory (BcCZO). NR 22 TC 2 Z9 2 U1 1 U2 4 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 USA SN 1523-0430 J9 ARCT ANTARCT ALP RES JI Arct. Antarct. Alp. Res. PD MAY PY 2010 VL 42 IS 2 BP 198 EP 209 DI 10.1657/1938-4246-42.2.198 PG 12 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA 602BT UT WOS:000278113800006 ER PT J AU Turbyville, JC Rao, VK AF Turbyville, Joseph C. Rao, V. Koneti TI The autoimmune lymphoproliferative syndrome: A rare disorder providing clues about normal tolerance SO AUTOIMMUNITY REVIEWS LA English DT Article DE ALPS; Autoimmune cytopenia; Double negative T cells; Endothelium; Fas ID FAS GENE-MUTATIONS; SYNDROME ALPS; T-CELLS; IMMUNOLOGICAL THROMBOCYTOPENIA; LYMPHOCYTE APOPTOSIS; IMMUNE CYTOPENIAS; MOLECULAR MIMICRY; DISEASE; LYMPHADENOPATHY; DEFECTS AB The autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic, non-malignant lymphoproliferation, autoimmunity often manifesting as multilineage cytopenias, and an increased risk of lymphoma. While considered a rare disease, there are currently over 250 patients with ALPS being followed at the National Institutes of Health in Bethesda, Maryland. Most of these patients have a mutation in the gene for the TNF receptor-family member Fas (CD 95, Apo-1), and about one-third have an unknown defect or mutations affecting function of other signaling proteins involved in the apoptotic pathway. While ALPS is one of the few autoimmune diseases with a known genetic defect, there remain unanswered questions regarding how a defect in apoptosis results in the observed phenotype. In addition to shedding light on the pathophysiology of this rare and fascinating condition, studying ALPS may improve our understanding of normal tolerance and more common, sporadic autoimmune disorders. Published by Elsevier B.V. C1 [Turbyville, Joseph C.] Walter Reed Army Med Ctr, Dept Allergy Immunol, Washington, DC 20307 USA. [Rao, V. Koneti] NIAID, ALPS Unit, LCID, NIH, Bethesda, MD 20892 USA. RP Turbyville, JC (reprint author), Walter Reed Army Med Ctr, Dept Allergy Immunol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM joseph.c.turbyville@us.army.mil FU NIH, NIAID, Bethesda, MD FX This research was supported by the Intramural Research Program of the NIH, NIAID, Bethesda, MD 20892. NR 40 TC 25 Z9 25 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1568-9972 J9 AUTOIMMUN REV JI Autoimmun. Rev. PD MAY PY 2010 VL 9 IS 7 SI SI BP 488 EP 493 DI 10.1016/j.autrev.2010.02.007 PG 6 WC Immunology SC Immunology GA 609QZ UT WOS:000278673500005 PM 20170754 ER PT J AU Ondrasik, S Russo, M Alsten, C AF Ondrasik, Sydney Russo, Michael Alsten, Christopher TI The Use of "Virtual Reality" Sound Technology in Psychophysiological Sleep Enhancement Training SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID INSOMNIA C1 [Ondrasik, Sydney; Russo, Michael] Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. [Ondrasik, Sydney] Drexel Univ, Philadelphia, PA 19104 USA. [Alsten, Christopher] Inner Hlth Inc, San Diego, CA USA. RP Ondrasik, S (reprint author), Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. NR 8 TC 2 Z9 2 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2010 VL 81 IS 5 BP 525 EP 526 DI 10.3357/ASEM.2764.2010 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 589FY UT WOS:000277133500013 PM 20464823 ER PT J AU Genovese, RF Sun, W Johnson, CC diTargiani, RC Doctor, BP Saxena, A AF Genovese, Raymond F. Sun, Wei Johnson, Christina C. diTargiani, Robert C. Doctor, Bhupendra P. Saxena, Ashima TI Safety of Administration of Human Butyrylcholinesterase and its Conjugates with Soman or VX in Rats SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY LA English DT Article ID HUMAN SERUM BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE ACTIVITY; CHOLINESTERASE ACTIVITY; INHALATION EXPOSURE; RHESUS-MONKEYS; PROTECTION; TOXICITY; PHYSOSTIGMINE; MICE; SCOPOLAMINE AB We evaluated the effects of conjugated enzyme-nerve agent product resulting from the inhibition of bioscavenger human serum butyrylcholinesterase (Hu BChE) by nerve agents soman or VX. Rats were trained on a multiple Fixed-Ratio 32, Extinction 30 sec. (FR32, Ext30) schedule of food reinforcement and then injected (i.m.) with Hu BChE (30 mg/kg), equivalent amounts of Hu BChE-soman conjugate (GDC), Hu BChE-VX conjugate, oxotremorine (OXO) (0.316 mg/kg) or vehicle (n = 8, each group). On the day of injection and on 10 subsequent daily sessions, performance was evaluated on the FR32, Ext30 schedule. Neither conjugates nor Hu BChE produced a performance deficit under the schedule. OXO produced a substantial decrease in responding on the day of administration, with complete recovery observed on subsequent sessions. None of the treatments affected circulating acetylcholinesterase (AChE) activity when evaluated 24-72 hr after injection. The dose of Hu BChE produced a 20,000-fold increase above baseline in circulating BChE activity. Pathological evaluation of organ systems approximately 2 weeks following administration of conjugates or Hu BChE alone did not show toxicity. Taken together, these results suggest that Hu BChE - nerve agent conjugates produced following bioscavenger protection against nerve agents soman and VX do not appear to be particularly toxic. These results add to the safety assessment of Hu BChE as a bioscavenger countermeasure against nerve agent exposure. C1 [Genovese, Raymond F.; Johnson, Christina C.] Walter Reed Army Inst Res, Div Psychiat, Silver Spring, MD 20910 USA. [Genovese, Raymond F.; Johnson, Christina C.] Walter Reed Army Inst Res, Div Neurosci, Silver Spring, MD 20910 USA. [Sun, Wei; diTargiani, Robert C.; Saxena, Ashima] Bacterial & Rickettesial Dis & Walter Reed Army I, Silver Spring, MD USA. RP Genovese, RF (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. EM raymond.genovese@us.army.mil FU Defense Threat Reduction Agency FX The authors thank Dr Mary Lou Klotz, for helpful comments on the design of the study and analysis of the results. The authors also thank Dr Lin Tang for assistance with the conduct of the study, MAJ Neel I. Aziz for pathology services and Mr Donald M. Maxwell at USAMRICD for preparing Hu BChE conjugates in his laboratory. This work was supported by funding from the Defense Threat Reduction Agency. NR 30 TC 10 Z9 10 U1 2 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1742-7835 J9 BASIC CLIN PHARMACOL JI Basic Clin. Pharmacol. Toxicol. PD MAY PY 2010 VL 106 IS 5 BP 428 EP 434 DI 10.1111/j.1742-7843.2009.00508.x PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 583FF UT WOS:000276658100011 PM 20050840 ER PT J AU Lu, ST D'Andrea, J Chalfin, S Crane, C Marchello, D Garay, R Hatcher, D Ziriax, J AF Lu, Shin-Tsu D'Andrea, John Chalfin, Steven Crane, Carrie Marchello, Donald Garay, Robert Hatcher, Donald Ziriax, John TI Absence of Corneal Endothelium Injury in Non-Human Primates Treated With and Without Ophthalmologic Drugs and Exposed to 2.8 GHz Pulsed Microwaves SO BIOELECTROMAGNETICS LA English DT Article DE corneal endothelial cell density; corneal thickness; pulsed microwave ID EYE; RADIATION AB Microwave-induced corneal endothelial damage was reported to have a low threshold (2.6 W/kg), and vasoactive ophthalmologic medications lowered the threshold by a factor of 10-0.26 W/kg. In an attempt to confirm these observations, four adult male Rhesus monkeys (Macaca mulatta) under propofol anesthesia were exposed to pulsed microwaves in the far field of a 2.8 GHz signal (1.43 +/- 0.061 mu s pulse width, 34 Hz pulse repetition frequency, 13.0 mW/cm(2) spatial and temporal average, and 464 mW/cm(2) spatial and temporal peak (291 W/cm(2) square wave equivalent) power densities). Corneal-specific absorption rate was 5.07 W/kg (0.39 W/kg/mW/cm(2)). The exposure resulted in a 1.0-1.2 degrees C increase in eyelid temperature. In Experiment I, exposures were 4 h/day, 3 days/week for 3 weeks (nine exposures and 36 h total). In Experiment II, these subjects were pretreated with 0.5% Timolol maleate and 0.005% Xalatan (R) followed by 3 or 74-h pulsed microwave exposures. Under ketamine xylazine anesthesia, a non-contact specular microscope was used to obtain corneal endothelium images, corneal endothelial cell density, and pachymetry at the center and four peripheral areas of the cornea. Ophthalmologic measurements were done before and 7, 30, 90, and 180 days after exposures. Pulsed microwave exposure did not cause alterations in corneal endothelial cell density and corneal thickness with or without ophthalmologic drugs. Therefore, previously reported changes in the cornea exposed to pulsed microwaves were not confirmed at exposure levels that are more than an order of magnitude higher. Bioelectromagnetics 31:324-333, 2010. Published 2010 Wiley-Liss. Inc. C1 [D'Andrea, John; Chalfin, Steven; Crane, Carrie; Marchello, Donald; Hatcher, Donald; Ziriax, John] USA, Med Res Unit San Antonio, Brooks City Base, TX 78235 USA. [Lu, Shin-Tsu; Garay, Robert] Henry M Jackson Fdn Adv Mil Med, Brooks City Base, TX USA. [Chalfin, Steven] Univ Texas Hlth Sci Ctr San Antonio, Dept Ophthalmol, San Antonio, TX 78229 USA. RP Ziriax, J (reprint author), USA, Med Res Unit San Antonio, 8315 Navy Rd, Brooks City Base, TX 78235 USA. EM john.ziriax@brooks.af.mil FU Office of Naval Research [62233NMM 3130.002.1706 DN240580] FX Grant sponsor: Office of Naval Research to John D'Andrea (62233NMM 3130.002.1706 DN240580). NR 17 TC 1 Z9 1 U1 0 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PD MAY PY 2010 VL 31 IS 4 BP 324 EP 333 DI 10.1002/bem.20556 PG 10 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA 585VQ UT WOS:000276858700010 PM 20112259 ER PT J AU Postolache, TT Manalai, P Slemi, A Kosisky, SE Lapidus, M Cabassa, JA Strassle, P Langenberg, P Hamilton, RG AF Postolache, Teodor T. Manalai, Partam Slemi, Amar Kosisky, Susan E. Lapidus, Manana Cabassa, Johanna A. Strassle, Paula Langenberg, Patricia Hamilton, Robert G. TI Allergen-Specific IgE and Allergy Symptoms are Associated with Depression Scores in Patients with Mood Disorders Exposed to Seasonal Pollen-Peaks SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 65th Annual Convention of the Society-of-Biological-Psychiatry CY MAY 20-22, 2010 CL New Orleans, LA SP Soc Biol Psychiat C1 [Postolache, Teodor T.; Manalai, Partam; Slemi, Amar; Lapidus, Manana; Cabassa, Johanna A.; Strassle, Paula; Langenberg, Patricia] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA. [Kosisky, Susan E.] Walter Reed Army Med Ctr, Dept Allergy & Immunol, US Army Centralized Allergen Extract Lab, Washington, DC 20307 USA. [Hamilton, Robert G.] Johns Hopkins Univ, Sch Med, Div Allergy & Clin Immunol, Dept Med, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2010 VL 67 IS 9 SU S MA 440 BP 124S EP 124S PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 588IX UT WOS:000277064200396 ER PT J AU Killgore, WDS Killgore, DB Kamimori, GH Balkin, TJ AF Killgore, William D. S. Killgore, Desiree B. Kamimori, Gary H. Balkin, Thomas J. TI Caffeine Reduces Behavioral Risk-Taking During Sleep Deprivation SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract CT 65th Annual Convention of the Society-of-Biological-Psychiatry CY MAY 20-22, 2010 CL New Orleans, LA SP Soc Biol Psychiat C1 [Killgore, William D. S.] McLean Hosp, Neuroimaging Ctr, Belmont, MA 02178 USA. [Killgore, William D. S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. [Killgore, William D. S.; Kamimori, Gary H.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 2010 VL 67 IS 9 SU S MA 579 BP 168S EP 169S PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 588IX UT WOS:000277064200534 ER PT J AU Liu, F Hakami, RM Dyas, B Bahta, M Lountos, GT Waugh, DS Ulrich, RG Burke, TR AF Liu, Fa Hakami, Ramin Mollaaghababa Dyas, Beverly Bahta, Medhanit Lountos, George T. Waugh, David S. Ulrich, Robert G. Burke, Terrence R., Jr. TI A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE Protein-tyrosine phosphatase; Yersinia pestis; YopH; Inhibitor ID DRUG DISCOVERY; CANCER; ACIDS AB A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibitors. The generality of the approach may potentially make it amenable to the development of bivalent inhibitors directed against other phosphatases. Published by Elsevier Ltd. C1 [Liu, Fa; Bahta, Medhanit; Burke, Terrence R., Jr.] NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA. [Hakami, Ramin Mollaaghababa] Oak Ridge Associated Univ, Fac Res Participat Program, Belcamp, MD 21017 USA. [Hakami, Ramin Mollaaghababa; Dyas, Beverly; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. [Lountos, George T.; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA. RP Liu, F (reprint author), Lilly Res Labs, Indianapolis, IN 46285 USA. EM tburke@helix.nih.gov RI Burke, Terrence/N-2601-2014; Lountos, George/B-3983-2015 FU NIH, Center for Cancer Research, NCI-Frederick; National Cancer Institute, National Institutes of Health and the Joint Science and Technology Office of the Department of Defense FX Appreciation is expressed to Afroz Sultana (LMI) for technical support. This work was supported in part by the Intramural Research Program of the NIH, Center for Cancer Research, NCI-Frederick and the National Cancer Institute, National Institutes of Health and the Joint Science and Technology Office of the Department of Defense. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. Appreciation is expressed to Afroz Sultana (LMI), Scott Cherry and Joe Tropea (MCL) for technical support. NR 30 TC 15 Z9 15 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD MAY 1 PY 2010 VL 20 IS 9 BP 2813 EP 2816 DI 10.1016/j.bmcl.2010.03.058 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 585HT UT WOS:000276816600024 PM 20350805 ER PT J AU Yeh, S Weichel, ED Faia, LJ Albini, TA Wroblewski, KK Stetler-Stevenson, M Ruiz, P Sen, HN Chan, CC Nussenblatt, RB AF Yeh, Steven Weichel, Eric D. Faia, Lisa J. Albini, Thomas A. Wroblewski, Keith K. Stetler-Stevenson, Maryalice Ruiz, Phillip Sen, H. Nida Chan, Chi Chao Nussenblatt, Robert B. TI 25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma SO BRITISH JOURNAL OF OPHTHALMOLOGY LA English DT Article ID POSTERIOR SEGMENT DISEASE; INTERLEUKIN-6 RATIO; GENE REARRANGEMENT; FLOW-CYTOMETRY; MANAGEMENT; UVEITIS; 20-GAUGE; BIOPSY AB Background/Aims Diagnostic pars plana vitrectomy is a useful technique in the diagnosis of intraocular lymphoma (IOL); however, the role of transconjunctival sutureless vitrectomy (TSV) has not been fully explored for this indication. The purpose of this study was to review our experience with 25-gauge TSV for the diagnosis of IOL. Methods Patients who underwent 25-gauge TSV for the diagnosis of IOL (primary, secondary or recurrent) from two tertiary referral centres were reviewed. Demographic data and underlying medical conditions were reviewed. Preoperative and postoperative visual acuities (VA) and ophthalmic examination data were assessed. Cytopathology, flow cytometry, cytokine and gene rearrangement studies were assessed. Results Twelve patients underwent 25-gauge diagnostic TSV with a median follow-up time of 37 weeks. B-cell or T-cell IOL was diagnosed based on cytology in 3/12 patients (25%, 95% CI 8.9 to 53.2%) and in eight patients (67%, 95% CI 39.1 to 86.1%) using adjunctive diagnostic testing. VA stabilised or improved in 11 eyes (92%). Mean VA improved from 20/95 to 20/66 (p=0.055, paired t test). Conclusions 25-Gauge TSV is safe and effective for obtaining vitreous specimens for the evaluation of IOL. The availability of expert ophthalmic pathological consultation, flow cytometry, cytokine evaluation and gene rearrangement studies were essential to the diagnosis. C1 [Nussenblatt, Robert B.] NEI, Immunol Lab, NIH, Bethesda, MD 20892 USA. [Weichel, Eric D.; Wroblewski, Keith K.] Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. [Albini, Thomas A.] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Miami, FL 33136 USA. [Stetler-Stevenson, Maryalice] NCI, Flow Cytometry Unit, Pathol Lab, NIH, Bethesda, MD 20892 USA. [Ruiz, Phillip] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL 33136 USA. [Ruiz, Phillip] Univ Miami, Miller Sch Med, Dept Pathol, Miami, FL 33136 USA. RP Nussenblatt, RB (reprint author), NEI, Immunol Lab, NIH, Bldg 10,10N-112,10 Ctr Dr, Bethesda, MD 20892 USA. EM DrBob@nei.nih.gov OI Albini, Thomas/0000-0003-2199-9047 FU National Eye Institute, National Institutes of Health; Heed Ophthalmic Foundation; Ronald G. Michels Foundation FX Funding This research is supported by Intramural Research Program of the National Eye Institute, National Institutes of Health. SY has received support from the Heed Ophthalmic Foundation and the Ronald G. Michels Foundation. NR 25 TC 8 Z9 10 U1 0 U2 1 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0007-1161 J9 BRIT J OPHTHALMOL JI Br. J. Ophthalmol. PD MAY PY 2010 VL 94 IS 5 BP 633 EP 638 DI 10.1136/bjo.2009.167940 PG 6 WC Ophthalmology SC Ophthalmology GA 592JH UT WOS:000277374500023 PM 20447965 ER PT J AU Lotufo, GR Blackburn, WM AF Lotufo, G. R. Blackburn, W. M. TI Bioaccumulation of TNT and DDT in Sheepshead Minnows, Cyprinodon variegatus L., Following Feeding of Contaminated Invertebrates SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article DE TNT; DDT; Dietary uptake; Fish ID OCTANOL/WATER PARTITION-COEFFICIENT; CATFISH ICTALURUS-PUNCTATUS; ACCUMULATION; EXPOSURE AB The aim of this study was to determine the potential for dietary uptake by trophic transfer using the explosive 2,4,6-trinitrotoluene (TNT) and the substantially more hydrophobic dichlorodiphenyltrichloroethane (DDT) utilizing the amphipods Leptocheirus plumulosus as prey and the fish Cyprinodon variegatus as predator. Bioaccumulation did not change significantly over time for TNT but apparent steady-state was not reached for DDT at exposure termination after 7 days of dietary exposure. The bioaccumulation factor was 0.09 mg/mg for TNT and 0.34 mg/mg for DDT, confirming the low potential of TNT to bioaccumulate in fish. C1 [Lotufo, G. R.; Blackburn, W. M.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Lotufo, GR (reprint author), USA, Engineer Res & Dev Ctr, Waterways Expt Stn, EP-R,3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM guilherme.lotufo@usace.army.mil FU US Navy; US Army; Chief of Naval Operations [N456]; Chief of Engineers FX The US Navy's Pollution Abatement Ashore Environmental Sustainability Development to Integration Program and the Environmental Quality Technology Research Program of the US Army supported this research. Permission to publish this study was granted by the Chief of Naval Operations (N456) and the Chief of Engineers. NR 10 TC 1 Z9 1 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD MAY PY 2010 VL 84 IS 5 BP 545 EP 549 DI 10.1007/s00128-010-9978-z PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 599TJ UT WOS:000277936000008 PM 20422149 ER PT J AU Perez, SA von Hofe, E Kallinteris, NL Gritzapis, AD Peoples, GE Papamichail, M Baxevanis, CN AF Perez, Sonia A. von Hofe, Eric Kallinteris, Nikoletta L. Gritzapis, Angelos D. Peoples, George E. Papamichail, Michael Baxevanis, Constantin N. TI A New Era in Anticancer Peptide Vaccines SO CANCER LA English DT Review DE cancer peptide vaccines; multiepitopes; long peptides; preventive vaccinations; chemotherapy; combined immunotherapy ID T-CELL IMMUNITY; CERVICAL-CANCER PATIENTS; MHC CLASS-I; PROSTATE-CANCER; CLINICAL-TRIAL; LUNG-CANCER; STEM-CELLS; PHASE-II; INDUCTION; VACCINATION AB The use of synthetic peptides as vaccines aimed at the induction of therapeutic CD8-positive T-cell responses against tumor cells initially experienced great enthusiasm, mostly because of advances in vaccine technology, including design, synthesis, and delivery. However, despite impressive results in animal models, the application of such vaccines in humans has met with only limited success. The therapeutic activity of vaccine-stimulated, tumor-specific, CD8-positive T cells can be hampered through the physical burden of the tumor, tolerance mechanisms, and local factors within the tumor microenvironment. Recently, accumulating evidence has suggested that combining a peptide-based therapeutic vaccination with conventional chemotherapy can uncover the full potential of the antitumor immune response increasing the success of immunotherapy. In addition, therapeutic vaccination in the preventive setting has been extremely effective in eliciting antitumor responses in preclinical tumor models and has demonstrated good promise clinically in patients with minimal residual disease. The rationale behind preventive vaccination is that patients with minimal tumor burden still have a fully competent immune system capable of developing robust antitumor responses. Finally therapeutic CD8-positive T-cell peptide vaccines have been improved by coimmunization with T-helper epitopes expressed on long peptides. Cancer 2010;116:2071-80. (C) 2010 American Cancer Society. C1 [Perez, Sonia A.; Gritzapis, Angelos D.; Papamichail, Michael; Baxevanis, Constantin N.] St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens 11522, Greece. [von Hofe, Eric; Kallinteris, Nikoletta L.] Antigen Express Inc, Biotec 3, Worcester, MA USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. RP Baxevanis, CN (reprint author), St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, 171 Alexandras Ave, Athens 11522, Greece. EM baxevanis@ciic.gr NR 64 TC 52 Z9 53 U1 1 U2 14 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER-AM CANCER SOC JI Cancer PD MAY 1 PY 2010 VL 116 IS 9 BP 2071 EP 2080 DI 10.1002/cncr.24988 PG 10 WC Oncology SC Oncology GA 588YY UT WOS:000277111900004 PM 20187092 ER PT J AU Muratov, EN Kuz'min, VE Artemenko, AG Kovdienko, NA Gorb, L Hill, F Leszczynski, J AF Muratov, Eugene N. Kuz'min, Victor E. Artemenko, Anatoly G. Kovdienko, Nikolay A. Gorb, Leonid Hill, Frances Leszczynski, Jerzy TI New QSPR equations for prediction of aqueous solubility for military compounds SO CHEMOSPHERE LA English DT Article DE QSPR; SiRMS; EPI Suite (TM); Hazardous nitrocompounds ID SIMPLEX REPRESENTATION; MOLECULAR-STRUCTURE; DERIVATIVES; BINDING AB The development of a new quantitative structure-property relationship (QSPR) model to predict aqueous solubility (S(w)) accurately for compounds of military interest is presented. The ability of the new model to predict solubility is assessed and compared to available experimental data. A large set of structurally diverse organic compounds was used in this analysis. SiRMS methodology was employed to develop PLS models based on 135 training compounds and predictive accuracy was tested for 155 compounds selected for that purpose. The use of descriptors calculated only from the 2D level of representation of molecular structure produces a well-fitted and robust QSPR model (R(2)=0.90; Q(2)=0.87). Predictive ability for the model produced in this study on external test set (R(test)(2) = 0.81) is comparable to the predictive ability of EPI Suite (TM), 4.0. Consensus solubility predictions using SiRMS and EPI models for 25 compounds of military interest (not included into the training set) have been completed. Published by Elsevier Ltd. C1 [Kovdienko, Nikolay A.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Muratov, Eugene N.; Kuz'min, Victor E.; Artemenko, Anatoly G.] Natl Acad Sci Ukraine, Lab Theoret Chem, Dept Mol Struct, AV Bogatsky Phys Chem Inst, UA-65080 Odessa, Ukraine. [Gorb, Leonid] SpecPro Inc, Vicksburg, MS 39180 USA. [Hill, Frances; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, 1400 JR Lynch St, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 NR 17 TC 8 Z9 8 U1 0 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD MAY PY 2010 VL 79 IS 8 BP 887 EP 890 DI 10.1016/j.chemosphere.2010.02.030 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA 602IL UT WOS:000278132600018 PM 20233619 ER PT J AU Allton, DR Rivard, RG Connolly, PA McCall, S Durkin, MM Boyd, TM Flanagan, JP Wheat, LJ Hospenthal, DR AF Allton, David R. Rivard, Robert G. Connolly, Patricia A. McCall, Suzanne Durkin, Michelle M. Boyd, Tonya M. Flanagan, Joseph P. Wheat, L. Joseph Hospenthal, Duane R. TI Detection of Latin American Strains of Histoplasma in a Murine Model by Use of a Commercially Available Antigen Test SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; AMPHOTERICIN-B; CAPSULATUM; ITRACONAZOLE; BATS; MICE AB During a Histoplasma outbreak in a colony of fruit bats at a southern United States zoo, it was observed that although Histoplasma was recovered in culture from multiple sites at necropsy, none of the samples collected from those bats tested positive for Histoplasma antigen (HAg). Five of the Histoplasma isolates from the bats were subsequently identified as Latin American (LA) clade A, restriction fragment length polymorphism (RFLP) class 6. These observations raised concern as to whether the commercially available HAg test could detect Histoplasma antigen not of the North American clade upon which the HAg test had been developed. To evaluate this concern, a murine model of disseminated histoplasmosis was established, and mice were infected with multiple LA Histoplasma isolates, including clinical isolates recovered from Brazilian AIDS patients (RFLP class 5 and class 6) and isolates recovered from the bats during the outbreak (RFLP class 6). Histoplasma antigen was detected in all infected mice in our experiments, even when Histoplasma was not recovered in culture. Because the currently available HAg test is able to detect Histoplasma antigen in mice infected with Latin American isolates, this suggests that bat host factors rather than differences among Histoplasma RFLP classes were responsible for the inability to detect HAg in infected bats. C1 [Hospenthal, Duane R.] Brooke Army Med Ctr, Infect Dis MCHE MDI, Ft Sam Houston, TX 78234 USA. [Connolly, Patricia A.; Durkin, Michelle M.; Wheat, L. Joseph] MiraVista Diagnost, Indianapolis, IN USA. [Boyd, Tonya M.; Flanagan, Joseph P.] Houston Zoo Inc, Houston, TX USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Infect Dis MCHE MDI, 2851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil NR 11 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2010 VL 17 IS 5 BP 802 EP 806 DI 10.1128/CVI.00043-10 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 590QX UT WOS:000277243200015 PM 20357054 ER PT J AU Chu, Q Mita, A Forouzesh, B Tolcher, AW Schwartz, G Nieto, A Soto-Matos, A Alfaro, V Lebedinsky, C Rowinsky, EK AF Chu, Quincy Mita, Alain Forouzesh, Bahram Tolcher, Anthony W. Schwartz, Gary Nieto, Antonio Soto-Matos, Arturo Alfaro, Vicente Lebedinsky, Claudia Rowinsky, Eric K. TI Phase I and Pharmacokinetic Study of Sequential Paclitaxel and Trabectedin Every 2 Weeks in Patients with Advanced Solid Tumors SO CLINICAL CANCER RESEARCH LA English DT Article ID SOFT-TISSUE SARCOMA; ADVANCED OVARIAN-CANCER; ECTEINASCIDIN-743 ET-743; BREAST-CANCER; BIWEEKLY PACLITAXEL; 3 H; INFUSION; PLATINUM; TRIAL; CYTOTOXICITY AB Purpose: This phase I study evaluated the feasibility, safety, pharmacokinetics (PK), and preliminary evidence of anticancer activity of the sequential administration of paclitaxel and trabectedin on an every-2-week schedule in patients with refractory solid malignancies. The study also sought to determine the maximum tolerated dose (MTD) level on this schedule, as well as to recommend doses for disease-directed studies. Experimental Design: Twenty-seven patients were treated with paclitaxel (80-120 mg/m(2); 1-hour i.v. infusion, day 1) and trabectedin (0.525-0.775 mg/m(2); 3-hour i.v. infusion, day 2) with doses increased in successive cohorts. Blood sampling for PK and drug-drug interaction studies was done. Results: Neutropenia, which resulted in treatment delay exceeding 1 week, was the principal dose-limiting toxicity for this paclitaxel-trabectedin regimen and precluded dose escalation above 120 mg/m(2) paclitaxel and 0.650 mg/m(2) trabectedin. At the MTD (120 mg/m(2) paclitaxel and 0.650 mg/m(2) trabectedin), the safety profile was favorable in patients receiving cumulative treatment. Relevant drug-drug PK interactions between paclitaxel and trabectedin were not identified. A patient with soft tissue sarcoma had a complete response and several patients with various refractory solid malignancies showed protracted stable disease as their best response. Conclusions: The MTD level of sequential paclitaxel 1-hour infusion (day 1) and trabectedin 3-hour infusion (day 2) administered every 2 weeks is 120 and 0.650 mg/m(2), respectively. The manageable toxicities at the MTD, preliminary evidence of antitumor activity, and lack of notable PK drug-drug interactions warrant further disease-directed studies of this regimen in relevant tumor types and settings. Clin Cancer Res; 16(9); 2656-65. (C) 2010 AACR. C1 [Chu, Quincy; Mita, Alain; Forouzesh, Bahram; Tolcher, Anthony W.; Rowinsky, Eric K.] Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. [Schwartz, Gary] Brooke Army Med Ctr, San Antonio, TX USA. [Nieto, Antonio; Soto-Matos, Arturo; Alfaro, Vicente; Lebedinsky, Claudia] PharmaMar Clin R&D, Madrid, Spain. RP Rowinsky, EK (reprint author), 33 ImClone Dr, Branchburg, NJ 08876 USA. EM eric.rowinsky@imclone.com NR 46 TC 14 Z9 14 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1078-0432 J9 CLIN CANCER RES JI Clin. Cancer Res. PD MAY 1 PY 2010 VL 16 IS 9 BP 2656 EP 2665 DI 10.1158/1078-0432.CCR-10-0062 PG 10 WC Oncology SC Oncology GA 608OX UT WOS:000278596100020 PM 20406837 ER PT J AU Petersen, M Mikita, C AF Petersen, M. Mikita, C. TI Retrospective Record Review of The Observed Structured Clinical Exam (OSCE) for Primary Immunodeficiency SO CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 1st North American Primary Immune Deficiency National Conference CY MAY 20-23, 2010 CL Philadelphia, PA C1 [Petersen, M.; Mikita, C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD MAY PY 2010 VL 135 IS 2 SI SI MA 40 BP 300 EP 301 PG 2 WC Immunology SC Immunology GA 588ZH UT WOS:000277112900052 ER PT J AU Mikita, C AF Mikita, C. TI Common Variable Immunodeficiency Presenting as Chronic Diarrhea SO CLINICAL IMMUNOLOGY LA English DT Meeting Abstract CT 1st North American Primary Immune Deficiency National Conference CY MAY 20-23, 2010 CL Philadelphia, PA C1 [Mikita, C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1521-6616 J9 CLIN IMMUNOL JI Clin. Immunol. PD MAY PY 2010 VL 135 IS 2 SI SI MA 127 BP 337 EP 337 PG 1 WC Immunology SC Immunology GA 588ZH UT WOS:000277112900137 ER PT J AU Glen, AG AF Glen, Andrew G. TI Maximum likelihood estimation using probability density functions of order statistics SO COMPUTERS & INDUSTRIAL ENGINEERING LA English DT Article DE Computational probability; Interval censoring; Life tests ID MODEL AB A variation of maximum likelihood estimation (MLE) of parameters that uses probability density functions of order statistic is presented. Results of this method are compared with traditional maximum likelihood estimation for complete and right-censored samples in a life test. Further, while the concept can be applied to most types of censored data sets, results are presented in the case of order statistic interval censoring, in which even a few order statistics estimate well, compared to estimates from complete and right-censored samples. Distributions investigated include the exponential, Rayleigh, and normal distributions. Computation methods using A Probability Programming Language running in Maple are more straightforward than existing methods using various numerical method algorithms. Published by Elsevier Ltd. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Glen, AG (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM andrew.glen@usma.edu NR 15 TC 0 Z9 0 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-8352 J9 COMPUT IND ENG JI Comput. Ind. Eng. PD MAY PY 2010 VL 58 IS 4 BP 658 EP 662 DI 10.1016/j.cie.2010.01.008 PG 5 WC Computer Science, Interdisciplinary Applications; Engineering, Industrial SC Computer Science; Engineering GA 600AC UT WOS:000277954700017 ER PT J AU Ellsworth, RE Decewicz, DJ Shriver, CD Ellsworth, DL AF Ellsworth, Rachel E. Decewicz, David J. Shriver, Craig D. Ellsworth, Darrell L. TI Breast Cancer in the Personal Genomics Era SO CURRENT GENOMICS LA English DT Article DE Breast cancer; personal genomics; genetic tests; gene expression; risk assessment ID BRCA2 MUTATION CARRIERS; GENE-EXPRESSION SIGNATURE; RISK-ASSESSMENT MODELS; DNA-REPAIR DEFECT; OVARIAN-CANCER; WIDE ASSOCIATION; SUSCEPTIBILITY GENE; FAMILY-HISTORY; PROGNOSTIC-SIGNIFICANCE; CONFER SUSCEPTIBILITY AB Breast cancer is a heterogeneous disease with a complex etiology that develops from different cellular lineages, progresses along multiple molecular pathways, and demonstrates wide variability in response to treatment. The "standard of care" approach to breast cancer treatment in which all patients receive similar interventions is rapidly being replaced by personalized medicine, based on molecular characteristics of individual patients. Both inherited and somatic genomic variation is providing useful information for customizing treatment regimens for breast cancer to maximize efficacy and minimize adverse side effects. In this article, we review (1) hereditary breast cancer and current use of inherited susceptibility genes in patient management; (2) the potential of newly-identified breast cancer-susceptibility variants for improving risk assessment; (3) advantages and disadvantages of direct-to-consumer testing; (4) molecular characterization of sporadic breast cancer through immunohistochemistry and gene expression profiling and opportunities for personalized prognostics; and (5) pharmacogenomic influences on the effectiveness of current breast cancer treatments. Molecular genomics has the potential to revolutionize clinical practice and improve the lives of women with breast cancer. C1 [Shriver, Craig D.; Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn Advancement Mil Med, Clin Breast Care Project, Windber, PA USA. [Decewicz, David J.; Ellsworth, Darrell L.] Walter Reed Army Med Ctr, Clin Breast Care Project, Windber, PA USA. RP Ellsworth, DL (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM d.ellsworth@wriwindber.org FU United States Department of Defense (Military Molecular Medicine Initiative) [MDA W81XWH-05-2-0075]; Clinical Breast Care Project FX This research was supported by the United States Department of Defense (Military Molecular Medicine Initiative MDA W81XWH-05-2-0075, protocol #01-20006) and was performed under the auspices of the Clinical Breast Care Project, a joint effort of many investigators and staff members whose contributions are gratefully acknowledged. The opinion and assertions contained herein are the private views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense. NR 150 TC 33 Z9 33 U1 1 U2 11 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1389-2029 J9 CURR GENOMICS JI Curr. Genomics PD MAY PY 2010 VL 11 IS 3 BP 146 EP 161 PG 16 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA 589CZ UT WOS:000277124000001 PM 21037853 ER PT J AU Difurio, MJ Mailhiot, T Sundborg, MJ Nauschuetz, KK AF Difurio, Megan J. Mailhiot, Thomas Sundborg, Michael J. Nauschuetz, Karen K. TI Comparison of the Clinical Significance of the Papanicolaou Test Interpretations LSIL Cannot Rule Out HSIL and ASC-H SO DIAGNOSTIC CYTOPATHOLOGY LA English DT Article DE ASC-H; LSIL cannot rule out HSIL; ASCCP guidelines; ThinPrep; The Bethesda System ID SQUAMOUS INTRAEPITHELIAL LESION; FOLLOW-UP; EXCLUDE HSIL; CATEGORY; CELLS; DIAGNOSIS; CYTOLOGY; OUTCOMES; SYSTEM; SMEAR AB Despite the two-tiered classification of dysplasia in The Bethesda System (TBS), rare cases fall into the category squamous intraepithelial lesion (SIL) of indeterminate grade. These Pap tests are often interpreted as "LSIL/ASC-H" or "LSIL" with a comment indicating the presence of cells with features approaching HSIL. Patients with LSIL/ASC-H have a significant risk of CIN 2 or worse (29-61.5%) on follow-up cervical biopsies, similar to the risk of CIN 2 or worse in patients with ASC-H Pap tests (24-68%). The purpose of this study was to compare patients with ASC-H and LSIL/ASC-H Pap tests. Women with LSIL/ASC-H had a slightly lower incidence of CIN 2 or worse (PPV = 35.6%, 95% CI: 29.8-41.4%) on follow-up cervical biopsy than the control ASC-H group (PPV = 40.2%, 95% Cl: 31.9-56.3%); this difference was not statistically significant. The difference in the distribution of the biopsy results' between the two groups was statistically significant (P < 0.001). The current guidelines for the management of cervical cytologic abnormalities from the American Society for Colposcopy and Cervical Pathology (ASCCP) advocate similar treatment algorithms for both LSIL and ASC-H. The main difference is the option of cytologic follow-up or HPV testing for certain special populations," as an alternative to colposcopy, for LSIL Pap test results. Based on our results, we recommend (I) LSIL/ASC-H to be added to TBS classification and (2) Pap test cases of LSIL/ASC-H may need to be clinically followed in a manner similar to ASC-H, i.e., colposcopy for all patients. Diagn. Cytopathol. 2010;38:313-317. (C) 2009 Wiley-Liss, Inc.(dagger) C1 [Difurio, Megan J.; Mailhiot, Thomas; Nauschuetz, Karen K.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Difurio, Megan J.; Mailhiot, Thomas; Nauschuetz, Karen K.] Brooke Army Med Ctr, Area Lab Serv, Ft Sam Houston, TX 78234 USA. [Sundborg, Michael J.] Brooke Army Med Ctr, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. RP Difurio, MJ (reprint author), MCXC PA, Dept Army, WAMC Stop A,2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM pathqueen@hotmail.com NR 29 TC 13 Z9 13 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 8755-1039 J9 DIAGN CYTOPATHOL JI Diagn. Cytopathol. PD MAY PY 2010 VL 38 IS 5 BP 313 EP 317 DI 10.1002/dc.21194 PG 5 WC Medical Laboratory Technology; Pathology SC Medical Laboratory Technology; Pathology GA 591TM UT WOS:000277327400001 PM 19813258 ER PT J AU Severinghaus, JP Albert, MR Courville, ZR Fahnestock, MA Kawamura, K Montzka, SA Muhle, J Scambos, TA Shields, E Shuman, CA Suwa, M Tans, P Weiss, RF AF Severinghaus, Jeffrey P. Albert, Mary R. Courville, Zoe R. Fahnestock, Mark A. Kawamura, Kenji Montzka, Stephen A. Muehle, Jens Scambos, Ted A. Shields, Erin Shuman, Christopher A. Suwa, Makoto Tans, Pieter Weiss, Ray F. TI Deep air convection in the firn at a zero-accumulation site, central Antarctica SO EARTH AND PLANETARY SCIENCE LETTERS LA English DT Article DE convective zone; nitrogen isotopes; firn gas; snow metamorphism; ice core; greenhouse gas phasing ID ABRUPT CLIMATE-CHANGE; LAST GLACIAL PERIOD; POLAR ICE; ATMOSPHERIC HYDROXYL; TRAPPED AIR; SIPLE-DOME; CLOSE-OFF; SNOW; AGE; CONSTRAINTS AB Ice cores provide unique archives of past atmospheres and climate, but interpretation of trapped-gas records and their climatic significance has been hampered by a poor knowledge of the prevalence of air convection in the firn layer on top of polar ice sheets. In particular, the phasing of greenhouse gases and climate from ice cores has been obscured by a discrepancy between empirical and model-based estimates of the age difference between trapped gases and enclosing ice, which may be due to air convection. Here we show that deep air convection (>23 m) occurs at a windy, near-zero-accumulation rate site in central Antarctica known informally as the Megadunes site (80.77914 degrees S, 124.48796 degrees E). Deep convection is evident in depth profiles of air withdrawn from the firn layer, in the observed pattern of the nitrogen isotope ratio (15)N/(14)N, the argon isotope ratio (40)Ar/(36)Ar, and in the mixing ratios of the anthropogenic halocarbons methyl chloroform (CH(3)CCl(3)) and HFC-134a (CH(2)FCF(3)). Transport parameters (diffusivities) were inferred and air was dated using measured carbon dioxide (CO(2)) and methane (CH(4)) mixing ratios, by comparing with the Law Dome atmospheric record, which shows that these are the oldest firn air samples ever recovered (CO(2) mean age = 1863 AD). The low accumulation rate and the consequent intense metamorphism of the firn (due to prolonged exposure to seasonal temperature cycling) likely contribute to deep air convection via large grain size and vertical cracks that act as conduits for vigorous air motion. The Megadunes site provides a possible modern analog for the glacial conditions in the Vostok, Dome Fuji, and Dome C ice core records and a possible explanation for lower-than-expected (15)N/(14)N ratios in trapped air bubbles at these times. A general conclusion is that very low accumulation rate causes deep air convection via its effect on firn structural characteristics. (C) 2010 Elsevier B.V. All rights reserved. C1 [Severinghaus, Jeffrey P.; Muehle, Jens; Shields, Erin; Weiss, Ray F.] Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA 92093 USA. [Albert, Mary R.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Courville, Zoe R.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Fahnestock, Mark A.] Univ New Hampshire, Ctr Study Complex Syst, Durham, NH 03824 USA. [Kawamura, Kenji] Natl Inst Polar Res, Itabashi Ku, Tokyo 1738515, Japan. [Montzka, Stephen A.; Tans, Pieter] NOAA Earth Syst Res Lab, Boulder, CO 80305 USA. [Scambos, Ted A.] Univ Colorado, Natl Snow & Ice Data Ctr, Boulder, CO 80301 USA. [Shuman, Christopher A.] Univ Maryland, Goddard Earth Sci & Technol Ctr, NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Suwa, Makoto] Princeton Univ, Dept Geosci, Princeton, NJ 08544 USA. RP Severinghaus, JP (reprint author), Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA 92093 USA. EM jseveringhaus@ucsd.edu RI Kawamura, Kenji/C-7660-2011; Fahnestock, Mark/N-2678-2013; OI Montzka, Stephen/0000-0002-9396-0400; Kawamura, Kenji/0000-0003-1163-700X; Albert, Mary/0000-0001-7842-2359 FU NSF [OPP 02-30452, OPP 01-25276]; NOAA's Climate Program Office FX Richard Alley suggested the idea of sampling firn air at the Megadunes site. Michael Bender inspired much of this work and made the delta15N measurements in his lab at Princeton. Two anonymous reviewers substantially improved the manuscript. We thank Louise Albershardt of Ice Coring and Drilling Services for the drilling and for making do with an unfinished (and partially functioning) drill. Special thanks go to the 2003-2004 Light Ground Traverse for their extraordinary efforts in preparing the runway that enabled LC-130 landings at the Megadunes site. Support for this work came from NSF-OPP 02-30452 (J.P.S.), NSF-OPP 01-25276 (ancillary field data), and the Atmospheric Composition and Climate Program of NOAA's Climate Program Office (S.A.M.). NR 53 TC 36 Z9 36 U1 3 U2 25 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0012-821X J9 EARTH PLANET SC LETT JI Earth Planet. Sci. Lett. PD MAY 1 PY 2010 VL 293 IS 3-4 BP 359 EP 367 DI 10.1016/j.epsl.2010.03.003 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 598ES UT WOS:000277816900014 ER PT J AU Villeneuve, DL Garcia-Reyero, N Martinovic, D Mueller, ND Cavallin, JE Durhan, EJ Makynen, EA Jensen, KM Kahl, MD Blake, LS Perkins, EJ Ankley, GT AF Villeneuve, Daniel L. Garcia-Reyero, Natalia Martinovic, Dalma Mueller, Nathaniel D. Cavallin, Jenna E. Durhan, Elizabeth J. Makynen, Elizabeth A. Jensen, Kathleen M. Kahl, Michael D. Blake, Lindsey S. Perkins, Edward J. Ankley, Gerald T. TI I. Effects of a dopamine receptor antagonist on fathead minnow, Pimephales promelas, reproduction SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Endocrine disruption; Neurotransmitter; Antipsychotic; Neuroendocrine; Gonadotropin-releasing hormone; Fish; Fecundity; Secondary sex characteristics ID GONADOTROPIN-RELEASE; SYNTHETIC ESTROGEN; HORMONE; FISH; 17-BETA-TRENBOLONE; ENDOCRINOLOGY; KETOCONAZOLE; VINCLOZOLIN; INHIBITION; OVULATION AB Neurotransmitters such as dopamine play an important role in regulating fish reproduction. However, the potential for neuroendocrine active chemicals to disrupt fish reproduction has not been well studied, despite emerging evidence of their discharge into aquatic environments. This study is the first to apply the fathead minnow 21 d reproduction assay developed for the US Endocrine Disruptor Screening Program to evaluate the reproductive toxicity of a model neuroendocrine active chemical, the dopamine 2 receptor antagonist, haloperidol. Continuous exposure to up to 20 mu g haloperidol/L had no significant effects on fathead minnow fecundity, secondary sex characteristics, gonad histology, or plasma steroid and vitellogenin concentrations. The only significant effect observed was an increase in gonadotropin-releasing hormone (cGnRH) transcripts in the male brain. Results suggest that non-lethal concentrations of haloperidol do not directly impair fish reproduction. Potential effects of haloperidol on reproductive behaviors and gene expression were examined in a companion study. Published by Elsevier Inc. C1 [Villeneuve, Daniel L.; Mueller, Nathaniel D.; Cavallin, Jenna E.; Durhan, Elizabeth J.; Makynen, Elizabeth A.; Jensen, Kathleen M.; Kahl, Michael D.; Blake, Lindsey S.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39108 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Martinovic, Dalma] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. RP Villeneuve, DL (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM villeneuve.dan@epa.gov RI Mueller, Nathaniel/E-5864-2010; OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 FU US EPA National Center for Computational Toxicology; US Army Corps of Engineers FX The authors thank Katie J. Greene, Jeffrey D. Brodin, and Leah C. Wehmas for general laboratory assistance and Ann Linnum and Experimental Pathologies Laboratories for assistance with histological analyses. We thank IT Korte and L.W. Touart for comments on an earlier version of this manuscript. This work was supported in part by the US EPA National Center for Computational Toxicology and the Army Environmental Quality Program of the US Army Corps of Engineers. The manuscript has been reviewed in accordance with US EPA and US ACE guidelines and approved for publication. Approval does not indicate that the contents reflect the views of either Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 29 TC 14 Z9 14 U1 3 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD MAY PY 2010 VL 73 IS 4 BP 472 EP 477 DI 10.1016/j.ecoenv.2009.09.007 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 588VW UT WOS:000277103600002 PM 19783049 ER PT J AU Villeneuve, DL Garcia-Reyero, N Martinovic, D Mueller, ND Cavallin, JE Durhan, EJ Makynen, EA Jensen, KM Kahl, MD Blake, LS Perkins, EJ Ankley, GT AF Villeneuve, Daniel L. Garcia-Reyero, Natalia Martinovic, Dalma Mueller, Nathaniel D. Cavallin, Jenna E. Durhan, Elizabeth J. Makynen, Elizabeth A. Jensen, Kathleen M. Kahl, Michael D. Blake, Lindsey S. Perkins, Edward J. Ankley, Gerald T. TI II: Effects of a dopamine receptor antagonist on fathead minnow dominance behavior and ovarian gene expression in the fathead minnow and zebrafish SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Endocrine disruption; Microarray; Species comparison; Neurotransmitter; Purine biosynthesis; Antipsychotic; Toxicogenomics; Neuroendocrine; Ovary; Gonadotropins ID LESCH-NYHAN-DISEASE; AGGRESSIVE-BEHAVIOR; HUMAN PHARMACEUTICALS; PIMEPHALES-PROMELAS; PARKINSONS-DISEASE; ANIMAL-MODEL; REPRODUCTION; FISH; SEROTONIN; NEURONS AB Neurotransmitters such as dopamine play an important role in reproductive behaviors and signaling. Neuroendocrine-active chemicals in the environment have potential to interfere with and/or alter these processes. A companion study with the dopamine 2 receptor antagonist, haloperidol, found no evidence of a direct effect of the chemical on fish reproduction. This study considered haloperidol's potential effects on behavior and ovarian gene expression. Male fathead minnows exposed to 50 mu g haloperidol/L for 96 h were found to be significantly more dominant than control males. In terms of molecular signaling, investigated using oligonucleotide microarrays, there was little similarity in the identity and functions of genes differentially expressed in the ovaries of fathead minnows (Pimephales promelas) versus zebrafish (Danio rerio) exposed under the same conditions. Results suggest that non-lethal concentrations of haloperidol do not induce ovarian molecular responses that could serve as biomarkers of exposure to D2R antagonists, but may impact behavior. Published by Elsevier Inc. C1 [Villeneuve, Daniel L.; Mueller, Nathaniel D.; Cavallin, Jenna E.; Durhan, Elizabeth J.; Makynen, Elizabeth A.; Jensen, Kathleen M.; Kahl, Michael D.; Blake, Lindsey S.; Ankley, Gerald T.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, Duluth, MN 55804 USA. [Garcia-Reyero, Natalia; Perkins, Edward J.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39108 USA. [Garcia-Reyero, Natalia] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Martinovic, Dalma] Univ St Thomas, Dept Biol, St Paul, MN 55105 USA. RP Villeneuve, DL (reprint author), US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Midcontinent Ecol Div, 6201 Congdon Blvd, Duluth, MN 55804 USA. EM villeneuve.dan@epa.gov RI Mueller, Nathaniel/E-5864-2010; OI Martinovic-Weigelt, Dalma/0000-0002-9973-4965 FU US EPA National Center for Computational Toxicology; US Army Corps of Engineers FX The authors thank Katie J. Greene, Jeffrey D. Brodin, and Leah C. Wehmas for general laboratory assistance and Dr. Li Liu for bioinformatic analyses to identify homologous microarray features. We thank J.J. Korte and L.W. Touart for comments on an earlier version of this manuscript. This work was supported in part by the US EPA National Center for Computational Toxicology and the Army Environmental Quality Program of the US Army Corps of Engineers. The manuscript has been reviewed in accordance with US EPA and US ACE guidelines and approved for publication. Approval does not indicate that the contents reflect the views of either Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 40 TC 9 Z9 9 U1 3 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD MAY PY 2010 VL 73 IS 4 BP 478 EP 485 DI 10.1016/j.ecoenv.2009.09.018 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 588VW UT WOS:000277103600003 PM 19896709 ER PT J AU Driscoll, SBK McArdle, ME Menzie, CA Reiss, M Steevens, JA AF Driscoll, Susan B. Kane McArdle, Margaret E. Menzie, Charles A. Reiss, Mark Steevens, Jeffery A. TI A framework for using dose as a metric to assess toxicity of fish to PAHs SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Dose; Fish; Sediment; PAH ID POLYCYCLIC AROMATIC-HYDROCARBONS; ORGANIC-CHEMICALS; FRESH-WATER; FOOD-WEB; EXPOSURE; GROWTH; BIOACCUMULATION; FLUORANTHENE; BIOMARKER; RESPONSES AB The effects of PAHs on fish have been described in the literature, but the ability to assess risk to juvenile and adult fish from exposure to PAHs the field is currently hindered by the lack of a predictive dose-response exposure model. The goal of this paper is to present a framework that can be used to convert concentrations of PAHs in environmental media (e.g., water, food, and sediment) to a dose metric that is predictive of adverse effects. Examples of toxicity studies that can be considered within the framework are presented. Additional toxicity studies are needed to establish the potency and range of toxic responses to mixtures of PAHs that fish encounter in the environment. (C) 2009 Published by Elsevier Inc. C1 [Driscoll, Susan B. Kane; McArdle, Margaret E.; Menzie, Charles A.] Exponent Inc, Maynard, MA 01754 USA. [Reiss, Mark] US EPA, Div Environm Planning & Protect, New York, NY 10007 USA. [Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Driscoll, SBK (reprint author), Exponent Inc, 3 Clocktower Pl,Suite 205, Maynard, MA 01754 USA. EM sdriscoll@exponent.com FU US Army Corps of Engineers New York District; US Environmental Protection Agency FX We acknowledge the US Army Corps of Engineers New York District and the US Environmental Protection Agency for sponsoring this research. Permission has been granted by the Chief of Engineers to publish this material. The work presented in this paper has been internally reviewed by US EPA, but its publication does not signify that the contents reflect the views of the Agency. NR 32 TC 5 Z9 5 U1 1 U2 15 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD MAY PY 2010 VL 73 IS 4 BP 486 EP 490 DI 10.1016/j.ecoenv.2009.11.004 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 588VW UT WOS:000277103600004 ER PT J AU Soucek, DJ Dickinson, A Cropek, DM AF Soucek, David J. Dickinson, Amy Cropek, Donald M. TI Effects of millimeter wave carbon fibers on filter-feeding freshwater invertebrates SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY LA English DT Article DE Millimeter wave carbon fibers; Military obscurant; Toxicity; Daphnia magna; Corbicula fluminea; Filter feeding ID OXYGEN-CONSUMPTION; CORBICULA-FLUMINEA; CERIODAPHNIA-DUBIA; SODIUM-SULFATE; DYNAMIC ACTION; DAPHNIA-MAGNA; FOG OIL; RESPIRATION; TEMPERATURE; REACTIVITY AB The purpose of our study was to investigate the sub-lethal effects of millimeter wave carbon fibers (MWCF), a military obscurant, on filter-feeding freshwater invertebrates. We observed decreased survival, reproduction, and oxygen consumption in Daphnia magna at realistic loading rates. In experiments with the Asiatic clam (Corbicula fluminea), soft tissue dry weight and tissue condition index were not significantly different among control and MWCF exposed treatments; however, using a (15)N labeled alga as food, we observed decreased nitrogen turnover in tissues of clams exposed to MWCF, suggesting lower filtering or ingestion rates. Our findings combined with previous demonstrations of MWCF toxicity to green algae suggest that over a period of several months, bivalve growth may be inhibited, and cladoceran populations may be even more strongly affected by MWCF. Given that these fibers are persistent, further experiments should be conducted to determine the longer-term effects of contamination of water bodies with MWCF. (C) 2009 Elsevier Inc. All rights reserved. C1 [Soucek, David J.; Dickinson, Amy] Univ Illinois, Illinois Nat Hist Survey, Inst Nat Resource Sustainabil, Champaign, IL 61820 USA. [Cropek, Donald M.] USA Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Soucek, DJ (reprint author), Univ Illinois, Illinois Nat Hist Survey, Inst Nat Resource Sustainabil, Champaign, IL 61820 USA. EM d-soucek@inhs.uiuc.edu FU U.S. Army Corps of Engineers [W9132 T-06-2-0017] FX Support for this research was provided by the U.S. Army Corps of Engineers, Grant W9132 T-06-2-0017, under the program Threatened and Endangered Species Research to Reduce Training Restrictions. NR 38 TC 0 Z9 0 U1 2 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0147-6513 J9 ECOTOX ENVIRON SAFE JI Ecotox. Environ. Safe. PD MAY PY 2010 VL 73 IS 4 BP 500 EP 506 DI 10.1016/j.ecoenv.2009.10.015 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 588VW UT WOS:000277103600006 PM 19926133 ER PT J AU Acevedo, JL Nolan, J Markwell, JK Thompson, D AF Acevedo, Jason L. Nolan, Jennifer Markwell, J. Kevin Thompson, David TI Pleomorphic adenoma of the nasal cavity: A case report SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID SEPTUM AB Pleomorphic adenomas of the nasal cavity are rare. We describe the case of a middle-aged white man who presented to our clinic with a long history of unilateral nasal obstruction. Preoperative imaging was performed, and the patient was taken to the operating room for endoscopic excision of the lesion. Surgical margins were negative. The patient's nasal obstruction resolved, and he was doing well at his first postoperative visit. The pathologic diagnosis was a pleomorphic adenoma. We discuss the features and management of this entity. C1 [Acevedo, Jason L.; Nolan, Jennifer; Markwell, J. Kevin; Thompson, David] Walter Reed Army Med Ctr, Otolaryngol Head & Neck Surg Serv, Washington, DC 20307 USA. RP Acevedo, JL (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Jasag00@yahoo.com NR 12 TC 3 Z9 3 U1 0 U2 0 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD MAY PY 2010 VL 89 IS 5 BP 224 EP 226 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA 598XD UT WOS:000277872200008 PM 20461683 ER PT J AU Arts, G Davies, J Dobbs, M Ebke, P Hanson, M Hommen, U Knauer, K Loutseti, S Maltby, L Mohr, S Poovey, A Poulsen, V AF Arts, Gertie Davies, Jo Dobbs, Michael Ebke, Peter Hanson, Mark Hommen, Udo Knauer, Katja Loutseti, Stefania Maltby, Lorraine Mohr, Silvia Poovey, Angela Poulsen, Veronique TI AMEG: the new SETAC advisory group on aquatic macrophyte ecotoxicology SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article DE Aquatic macrophytes; Risk assessment; Tools; Guidance; Chemicals AB Primary producers play critical structural and functional roles in aquatic ecosystems; therefore, it is imperative that the potential risks of toxicants to aquatic plants are adequately assessed in the risk assessment of chemicals. The standard required macrophyte test species is the floating (non-sediment-rooted) duckweed Lemna spp. This macrophyte species might not be representative of all floating, rooted, emergent, and submerged macrophyte species because of differences in the duration and mode of exposure; sensitivity to the specific toxic mode of action of the chemical; and species-specific traits (e.g., duckweed's very short generation time). These topics were addressed during the workshop entitled "Aquatic Macrophyte Risk Assessment for Pesticides" (AMRAP) where a risk assessment scheme for aquatic macrophytes was proposed. Four working groups evolved from this workshop and were charged with the task of developing Tier 1 and higher-tier aquatic macrophyte risk assessment procedures. Subsequently, a SETAC Advisory Group, the Macrophyte Ecotoxicology Group (AMEG) was formed as an umbrella organization for various macrophyte working groups. The purpose of AMEG is to provide scientifically based guidance in all aspects of aquatic macrophyte testing in the laboratory and field, including prospective as well as retrospective risk assessments for chemicals. As AMEG expands, it will begin to address new topics including bioremediation and sustainable management of aquatic macrophytes in the context of ecosystem services. C1 [Arts, Gertie] Alterra WUR, NL-6700 AA Wageningen, Netherlands. [Davies, Jo] Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England. [Dobbs, Michael] Bayer CropSci LP, Res Triangle Pk, NC 27709 USA. [Ebke, Peter] Mesocosm GmbH, D-35315 Homberg, Ohm, Germany. [Hanson, Mark] Univ Manitoba, Winnipeg, MB R3T 2N2, Canada. [Hommen, Udo] Fraunhofer IME, D-57392 Schmallenberg, Germany. [Knauer, Katja] Fed Off Agr, CH-3003 Bern, Switzerland. [Loutseti, Stefania] Du Pont Hellas SA, Athens 15232, Greece. [Maltby, Lorraine] Univ Sheffield, Sheffield S10 2TN, S Yorkshire, England. [Mohr, Silvia] Fed Environm Agcy, D-12307 Berlin, Germany. [Poovey, Angela] USA, Corps Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Poulsen, Veronique] AFSSA DiVE Ecotoxicol & Environm Fate Unit, F-94704 Maisons Alfort, France. RP Arts, G (reprint author), Alterra WUR, POB 47, NL-6700 AA Wageningen, Netherlands. EM Gertie.Arts@wur.nl RI Hommen, Udo/K-2182-2013; Maltby, Lorraine/A-6702-2012; OI Maltby, Lorraine/0000-0003-3817-4033; Arts, Gertie H.P./0000-0003-4118-8065 NR 8 TC 6 Z9 7 U1 2 U2 12 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD MAY PY 2010 VL 17 IS 4 BP 820 EP 823 DI 10.1007/s11356-010-0309-z PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA 583EO UT WOS:000276656300002 PM 20191396 ER PT J AU Labare, MP Bays, JT Butkus, MA Snyder-Leiby, T Smith, A Goldstein, A Schwartz, JD Wilson, KC Ginter, MR Bare, EA Watts, RE Michealson, E Miller, N LaBranche, R AF Labare, Michael P. Bays, J. Timothy Butkus, Michael A. Snyder-Leiby, Teresa Smith, Alicia Goldstein, Amanda Schwartz, Jenna D. Wilson, Kristopher C. Ginter, Melody R. Bare, Elizabeth A. Watts, Robert E. Michealson, Elizabeth Miller, Nicole LaBranche, Rachel TI The effects of elevated carbon dioxide levels on a Vibrio sp isolated from the deep-sea SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article DE Carbon dioxide; Vibrio alginolyticus; 9NA; Direct injection; Deep-sea; Carbon sequestration ID OCEAN DISPOSAL; MEMBRANE DAMAGE; CO2; MORPHOLOGY; INJECTION; PRESSURE; IMPACTS; LYSIS; PH AB The effect of oceanic CO(2) sequestration was examined exposing a deep-sea bacterium identified as Vibrio alginolyticus (9NA) to elevated levels of carbon dioxide and monitoring its growth at 2,750 psi (1,846 m depth). The wild-type strain of 9NA could not grow in acidified marine broth below a pH of 5. The pH of marine broth did not drop below this level until at least 20.8 mM of CO(2) was injected into the medium. 9NA did not grow at this CO(2) concentration or higher concentrations (31.2 and 41.6 mM) for at least 72 h. Carbon dioxide at 10.4 mM also inhibited growth, but the bacterium was able to recover and grow. Exposure to CO(2) caused the cell to undergo a morphological change and form a dimple-like structure. The membrane was also damaged but with no protein leakage. C1 [Labare, Michael P.; Smith, Alicia; Goldstein, Amanda; Schwartz, Jenna D.; Wilson, Kristopher C.; Ginter, Melody R.; Bare, Elizabeth A.; Watts, Robert E.; Michealson, Elizabeth; Miller, Nicole; LaBranche, Rachel] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. [Bays, J. Timothy] Pacific NW Natl Lab, Richland, WA 99352 USA. [Butkus, Michael A.] US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. [Snyder-Leiby, Teresa] SUNY Coll New Paltz, Dept Biol, New Paltz, NY USA. RP Labare, MP (reprint author), US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA. EM michael.labare@USMA.edu FU Army Research Office; Department of Chemistry and Life Science's FX The authors thank Professor Frank Millero, University of Miami, for providing the sea water equilibrium model and Dr. Carl Wirsen for the strain of 9NA. This work was supported by a grant from the Army Research Office and the Department of Chemistry and Life Science's Undergraduate Research Program. NR 27 TC 9 Z9 9 U1 0 U2 8 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD MAY PY 2010 VL 17 IS 4 BP 1009 EP 1015 DI 10.1007/s11356-010-0297-z PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 583EO UT WOS:000276656300020 PM 20140649 ER PT J AU Morrison-Rodriguez, SM Pacha, LA Patrick, JE Jordan, NN AF Morrison-Rodriguez, S. M. Pacha, L. A. Patrick, J. E. Jordan, N. N. TI Community-associated methicillin-resistant Staphylococcus aureus infections at an Army training installation SO EPIDEMIOLOGY AND INFECTION LA English DT Article DE Antibiotic resistance; antimicrobial drugs; community outbreaks; methicillin-resistant Staphylococcus aureus (MRSA) ID RISK-FACTORS; CHANGING EPIDEMIOLOGY; UNITED-STATES; COLONIZATION; POPULATION; PREVALENCE; SKIN AB To assess the burden of community-associated methicillin-resistant Staphylococcus aureus (CA-M RSA) in a high-risk population, the monthly incidence of laboratory-confirmed M RSA in service members/trainees stationed at Fort Benning, Georgia, USA without hospitalization or surgery documented 30 days prior to infection was calculated for calendar years 2002-2007. Clinical management and antibiotic susceptibility patterns were also evaluated. By 2007, 67% of S. aureus strains were M RSA, and 82% of these were community-associated, primarily in trainees. In total, 3531 CA-MRSA infections were identified. Rates appeared to be seasonal, peaking at 42 cases/1000 soldiers in 2005, with rates remaining above 35/1000 soldiers thereafter. Increased prescription of effective antibiotics was documented. Susceptibility to clindamycin, ciprofloxacin, and levofloxacin decreased from 2002 to 2007 by 6%, 17%, and 14%, respectively. The sustained high prevalence of CA-M RSA observed highlights the need for more vigilant population-based counter-measures at military training installations. C1 [Morrison-Rodriguez, S. M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Morrison-Rodriguez, S. M.] Natl Ctr Med Intelligence, Ft Detrick, MD USA. [Pacha, L. A.; Jordan, N. N.] USA, Ctr Hlth Promot & Prevent Med, Gunpowder, MD USA. [Patrick, J. E.] Martin Army Community Hosp, Ft Benning, GA USA. RP Jordan, NN (reprint author), 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Nikki.jordan@us.army.mil NR 28 TC 18 Z9 18 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0950-2688 J9 EPIDEMIOL INFECT JI Epidemiol. Infect. PD MAY PY 2010 VL 138 IS 5 SI SI BP 721 EP 729 DI 10.1017/S0950268810000142 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 593XN UT WOS:000277496400016 PM 20096150 ER PT J AU Clive, KS Tyler, JA Clifton, GT Holmes, JP Mittendorf, EA Ponniah, S Peoples, GE AF Clive, Kevin S. Tyler, Josh A. Clifton, G. Travis Holmes, Jarrod P. Mittendorf, Elizabeth A. Ponniah, Sathibalan Peoples, George E. TI Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? SO EXPERT REVIEW OF VACCINES LA English DT Review DE adjuvant; cancer; GM-CSF; immunotherapy; vaccine ID COLONY-STIMULATING FACTOR; MYELOID SUPPRESSOR-CELLS; COLORECTAL-CARCINOMA PATIENTS; NECROSIS-FACTOR-ALPHA; PROSTATE-CANCER; METASTATIC MELANOMA; ANTITUMOR IMMUNITY; RANDOMIZED-TRIAL; CLINICAL-TRIALS; DENDRITIC CELLS AB Granulocyte macrophage colony-stimulating factor (GM-CSF) has been utilized in the clinical management of multiple disease processes. Most recently, GM-CSF has been incorporated into the treatment of malignancies as a sole therapy, as well as a vaccine adjuvant. While the benefits of GM-CSF in this arena have been promising, recent reports have suggested the potential for GM-CSF to induce immune suppression and, thus, negatively impact outcomes in the management of cancer patients. The purpose of this review is to critically evaluate these reports, while considering the most recent clinical data on immunotherapies. We aim to demonstrate the utility of this adjuvant, elucidate those instances in which GM-CSF may induce immune suppression and identify potential explanations for these recent findings. C1 [Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. [Clive, Kevin S.; Tyler, Josh A.; Clifton, G. Travis; Peoples, George E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Holmes, Jarrod P.] Naval Med Ctr San Diego, San Diego, CA USA. [Mittendorf, Elizabeth A.] MD Anderson Canc Ctr, Houston, TX USA. RP Peoples, GE (reprint author), Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD 20814 USA. EM georgepeoples2@hotmail.com NR 40 TC 26 Z9 30 U1 1 U2 4 PU EXPERT REVIEWS PI LONDON PA UNITEC HOUSE, 3RD FL, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND SN 1476-0584 J9 EXPERT REV VACCINES JI Expert Rev. Vaccines PD MAY PY 2010 VL 9 IS 5 BP 519 EP 525 DI 10.1586/ERV.10.40 PG 7 WC Immunology SC Immunology GA 599RT UT WOS:000277931500014 PM 20450326 ER PT J AU Castagna, J AF Castagna, JoAnne TI Vision Unveiled for "mosaic of Habitats" in the New York/New Jersey Estuary SO FISHERIES LA English DT News Item C1 USA, Corps Engineers, New York, NY USA. RP Castagna, J (reprint author), USA, Corps Engineers, New York, NY USA. EM JoAnne.Castagna@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0363-2415 J9 FISHERIES JI Fisheries PD MAY PY 2010 VL 35 IS 5 BP 213 EP + PG 3 WC Fisheries SC Fisheries GA 614NK UT WOS:000279066100002 ER PT J AU Phippen, NT Lowery, WJ Leath, CA Kost, ER AF Phippen, Neil T. Lowery, William J. Leath, Charles A., III Kost, Edward R. TI Epithelioid trophoblastic tumor masquerading as invasive squamous cell carcinoma SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Epithelioid trophoblastic tumor; Pre-operative evaluation; Cervical cancer; Antecedent pregnancy C1 [Phippen, Neil T.; Lowery, William J.; Leath, Charles A., III; Kost, Edward R.] Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX USA. RP Leath, CA (reprint author), Dept OB GYN, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM charles.leath@amedd.army.mil NR 4 TC 6 Z9 9 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY PY 2010 VL 117 IS 2 BP 387 EP 388 DI 10.1016/j.ygyno.2010.02.013 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 594LG UT WOS:000277538600041 PM 20223511 ER PT J AU Drake, ML Segalman, KA AF Drake, Matthew L. Segalman, Keith A. TI Complications of Small Joint Arthroplasty SO HAND CLINICS LA English DT Article DE Complications; Fractures; Implant; Pyrocarbon; Silicone; Small joint arthroplasty ID PROXIMAL INTERPHALANGEAL JOINT; SURFACE REPLACEMENT ARTHROPLASTY; PYROLYTIC CARBON ARTHROPLASTY; FLEXIBLE IMPLANT ARTHROPLASTY; LONG-TERM ASSESSMENT; SILICONE ARTHROPLASTY; FOLLOW-UP; METACARPOPHALANGEAL JOINTS; RESURFACING ARTHROPLASTY; POSTTRAUMATIC ARTHRITIS AB Arthritis in the small joints of the hand can be treated with arthrodesis or arthroplasty. Arthrodesis has known risks of infection, pain, and nonunion. Distal interphalangeal (DIP) arthroplasty has been successful in preserving motion and alleviating pain for distal DIP, proximal interphalangeal, and metacarpophalangeal joints. Unfortunately, complications arise that limit the success of surgery. Silicone implants have been reliable for many years but still present with the risks of infection, implant breakage, stiffness, and pain. Newer implant designs may limit some of these complications, but present with unique problems such as dislocations and loosening. It is not yet clear as to which type of implant provides the most reliable results, although implant arthroplasty appears to give better function than arthrodesis. Silicone arthroplasty does not lead to silicone synovitis and is a reliable procedure. Pyrocarbon implants are showing some promise, particularly in the osteoarthritic patient. C1 [Drake, Matthew L.; Segalman, Keith A.] Union Mem Hosp, Curtis Natl Hand Ctr, Baltimore, MD 21218 USA. [Drake, Matthew L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Segalman, Keith A.] Johns Hopkins Sch Med, Baltimore, MD 21287 USA. RP Segalman, KA (reprint author), Union Mem Hosp, Curtis Natl Hand Ctr, 3333 N Calvert St,200, Baltimore, MD 21218 USA. EM ksegalman@comcast.net NR 42 TC 16 Z9 17 U1 1 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-0712 J9 HAND CLIN JI Hand Clin. PD MAY PY 2010 VL 26 IS 2 BP 205 EP + DI 10.1016/j.hcl.2010.01.003 PG 10 WC Orthopedics SC Orthopedics GA 612HK UT WOS:000278887200006 PM 20494746 ER PT J AU Theeler, BJ Kenney, K Prokhorenko, OA Fideli, US Campbell, W Erickson, JC AF Theeler, Brett J. Kenney, Kimbra Prokhorenko, Olga A. Fideli, Ulgen S. Campbell, William Erickson, Jay C. TI Headache Triggers in the US Military SO HEADACHE LA English DT Article DE headache; military; triggers ID UNITED-STATES; MIGRAINE; PREVALENCE; SOLDIERS; INJURY; IMPACT AB Background.- Headaches can be triggered by a variety of factors. Military service members have a high prevalence of headache but the factors triggering headaches in military troops have not been identified. Objective.- The objective of this study is to determine headache triggers in soldiers and military beneficiaries seeking specialty care for headaches. Methods.- A total of 172 consecutive US Army soldiers and military dependents (civilians) evaluated at the headache clinics of 2 US Army Medical Centers completed a standardized questionnaire about their headache triggers. Results.- A total of 150 (87%) patients were active-duty military members and 22 (13%) patients were civilians. In total, 77% of subjects had migraine; 89% of patients reported at least one headache trigger with a mean of 8.3 triggers per patient. A wide variety of headache triggers was seen with the most common categories being environmental factors (74%), stress (67%), consumption-related factors (60%), and fatigue-related factors (57%). The types of headache triggers identified in active-duty service members were similar to those seen in civilians. Stress-related triggers were significantly more common in soldiers. There were no significant differences in trigger types between soldiers with and without a history of head trauma. Conclusion.- Headaches in military service members are triggered mostly by the same factors as in civilians with stress being the most common trigger. Knowledge of headache triggers may be useful for developing strategies that reduce headache occurrence in the military. C1 [Theeler, Brett J.] USA, William Beaumont Army Med Ctr, Dept Med, Neurol Serv, El Paso, TX 79920 USA. [Kenney, Kimbra] Uniformed Serv Univ Hlth Sci, Comprehens Natl Neurosci Program, Bethesda, MD 20814 USA. [Prokhorenko, Olga A.; Fideli, Ulgen S.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. [Campbell, William] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. [Erickson, Jay C.] USA, Madigan Army Med Ctr, Dept Med, Neurol Serv, Tacoma, WA USA. RP Theeler, BJ (reprint author), USA, William Beaumont Army Med Ctr, Dept Med, Neurol Serv, 5005 N Piedras, El Paso, TX 79920 USA. FU Congressionally Directed Medical Research Program FX Study supported by: The Comprehensive National Neuroscience Program at the Uniformed Services University of the Health Sciences by a grant from the Congressionally Directed Medical Research Program. NR 13 TC 14 Z9 14 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0017-8748 J9 HEADACHE JI Headache PD MAY PY 2010 VL 50 IS 5 BP 790 EP 794 DI 10.1111/j.1526-4610.2009.01571.x PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA 587OF UT WOS:000277001400006 PM 19925623 ER PT J AU Marti, JK Banks, KP Song, WS AF Marti, Jon K. Banks, Kevin P. Song, Won S. TI Novel use of hepatobiliary scintigraphy for the diagnosis of interleukin-2 cholangiopathy SO HELLENIC JOURNAL OF NUCLEAR MEDICINE LA English DT Article DE Interleukin-2; Cholangiopathy; Acalculous cholecystitis; Hepatobiliary scintigraphy ID HIGH-DOSE INTERLEUKIN-2; CANCER; GALLBLADDER AB We report a case of interleukin-2 (IL-2) induced cholangiopathy diagnosed with the aid of hepatobiliary scintigraphy. Patient was a 32 years old, male with history of metastatic melanoma. Computed tomography (CT) upon admission demonstrated worsening of patient's metastatic lung disease with a normal appearance of the gallbladder. The patient was started on high dose IL-2 treatment for regression of his disease. Four days after IL-2 treatment was begun, the patient developed severe right upper quadrant pain and elevated liver function tests. A right upper quadrant ultrasound and surgical consultation were requested. Sonographic findings demonstrated diffuse gallbladder wall thickening, mural edema, a positive sonographic Murphy's sign, but no gallstones. The preliminary working diagnosis was acalculous cholecystitis versus IL-2 induced cholangiopathy. To clarify between these two entities, a hepatobiliary scan was obtained that demonstrated filling of the gallbladder with prompt biliary-to-bowel transit and normal liver function. In this case, the clinical presentation and history of recent IL-2 treatment were suggestive of IL-2 cholangiopathy, though the patient's co-morbidities and in-patient status raised concern for acalculous cholecystitis. Given the marked differences in treatment, hepatobiliary imaging was requested and found to be normal, making acalculous cholecystitis very unlikely. In conclusion, we believe this is the first case in which hepatobiliary scintigraphy was used to aid in the diagnosis of IL-2 induced cholangiopathy. C1 [Banks, Kevin P.] Brooke Army Med Ctr, Nucl Med Serv, Ft Sam Houston, TX 78234 USA. [Marti, Jon K.] Wilford Hall USAF Med Ctr, Dept Radiol, Lackland AFB, TX 78236 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Nucl Med Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 7 TC 4 Z9 4 U1 0 U2 0 PU HELLENIC SOC NUCLEAR MEDICINE PI THESSALONIKI PA 51 HERMU ST, THESSALONIKI, 546 23, GREECE SN 1790-5427 J9 HELL J NUCL MED JI Hell. J. Nucl. Med. PD MAY-AUG PY 2010 VL 13 IS 2 BP 163 EP 165 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 643WH UT WOS:000281330000010 PM 20808991 ER PT J AU Starley, BQ Calcagno, CJ Harrison, SA AF Starley, Brad Q. Calcagno, Christopher J. Harrison, Stephen A. TI Nonalcoholic Fatty Liver Disease and Hepatocellular Carcinoma: A Weighty Connection SO HEPATOLOGY LA English DT Review ID CHRONIC HEPATITIS-C; INDEPENDENT RISK-FACTOR; POPULATION-BASED COHORT; TERM-FOLLOW-UP; NATURAL-HISTORY; CRYPTOGENIC CIRRHOSIS; METABOLIC SYNDROME; UNITED-STATES; INSULIN-RESISTANCE; DIABETES-MELLITUS AB Hepatocellular carcinoma (HCC) is a common and deadly malignancy that is increasing in incidence in developed countries. The emergence of hepatitis C virus (HCV) accounts for about half of this increase in HCC, although the etiology of HCC in 15%-50% of new HCC cases remains unclear. The most common form of chronic liver disease in developed countries is nonalcoholic fatty liver disease (NAFLD), which encompasses a broad spectrum of histopathology. The prevalence of NAFLD, including the more aggressive nonalcoholic steatohepatitis (NASH), is increasing with the growing epidemics of diabetes and obesity. NASH can progress to cirrhosis and its related complications. Growing evidence suggests that NASH accounts for a large proportion of idiopathic or cryptogenic cirrhosis, which is associated with the typical risk factors for NASH. HCC is a rare, although important complication of NAFLD. Diabetes and obesity have been established as independent risk factors for the development of HCC. New evidence also suggests that hepatic iron deposition increases the risk of HCC in NASH-derived cirrhosis. Multiple case reports and case reviews of HCC in the setting of NASH support the associations of diabetes and obesity with the risk of HCC, as well as suggest age and advanced fibrosis as significant risks. Insulin resistance and its subsequent inflammatory cascade that is associated with the development of NASH appear to play a significant role in the carcinogenesis of HCC. The complications of NASH, including cirrhosis and HCC, are expected to increase with the growing epidemic of diabetes and obesity. (HEPATOLOGY 2010;51:1820-1832) C1 [Starley, Brad Q.; Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 133 TC 545 Z9 559 U1 16 U2 78 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD MAY PY 2010 VL 51 IS 5 BP 1820 EP 1832 DI 10.1002/hep.23594 PG 13 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 590XJ UT WOS:000277261400039 PM 20432259 ER PT J AU Veliadis, V Stewart, EJ Hearne, H Snook, M Lelis, A Scozzie, C AF Veliadis, V. Stewart, E. J. Hearne, H. Snook, M. Lelis, A. Scozzie, C. TI A 9-kV Normally-ON Vertical-Channel SiC JFET for Unipolar Operation SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE Current gain; JFET; normally-ON; unipolar; vertical channel; 10 kV; 4H-SiC ID FIELD-EFFECT TRANSISTORS; 4H-SIC POWER DMOSFET; KV; TEMPERATURE; SWITCH; VJFET; AREA AB A normally-ON 9-kV (at 0.1-mA/cm(2) drain leakage) 1.52 x 10(-3)-cm(2) active-area vertical-channel SiC JFET (VJFET) is fabricated with no e-beam lithography, no epitaxial regrowth, and a three-step junction-termination-extension edge termination, which is connected to the gate bus through an ion-implanted sloped extension. The VJFET exhibits low leakage currents and a sharp onset of gate-voltage breakdown occurring at 80 V. To lower resistance, the VJFET is designed to be very normally-ON, which minimizes the channel resistance contribution. At a gate bias of 0 V, the VJFET's drain current is 73 mA with a forward drain voltage drop of 5 V (240 W/cm(2)), a specific ON-state resistance of 104 m Omega . cm(2), and a current gain of I-D/I-G = 6.4 x 10(6). Operating at a unipolar gate bias of 2.5 V lowers the ON-state resistance to 96 m Omega . cm(2) and raises the drain-current output to 79.3 mA, with the current gain being relatively high at I-D/I-G = 2346. Thus, this 9-kV VJFET is capable of efficient power switching operation with high current gain at a low unipolar resistance. C1 [Veliadis, V.; Stewart, E. J.; Hearne, H.; Snook, M.] Northrop Grumman Adv Technol Lab, Linthicum, MD 21090 USA. [Lelis, A.; Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Veliadis, V (reprint author), Northrop Grumman Adv Technol Lab, Linthicum, MD 21090 USA. FU Army Research Laboratory [W911NF-06-2-0002] FX This work was supported by the Army Research Laboratory under Cooperative Agreement W911NF-06-2-0002. The views and conclusions contained in this letter are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Laboratory or the U. S. government. The U.S. government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation hereon. The review of this letter was arranged by Editor S.-H. Ryu. NR 20 TC 17 Z9 17 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0741-3106 EI 1558-0563 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAY PY 2010 VL 31 IS 5 BP 470 EP 472 DI 10.1109/LED.2010.2042030 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 588DL UT WOS:000277047300030 ER PT J AU Whitman, GM Wu, MYC Schwering, FK AF Whitman, Gerald M. Wu, Michael Y-C. Schwering, Felix K. TI Propagation and Scattering of Spherical Wave Pulses in Vegetation Using Scalar Transport Theory SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE Pulse propagation in vegetation; scattering in random media; spherical waves; transport theory ID EQUATION AB A high frequency theoretical model of propagation and scattering in vegetation is presented which uses scalar radiative transport theory. The specific problem analyzed is that of a periodic sequence of Gaussian pulses incident from free space into a forest region (vegetation). The incident pulse train is taken to be a spherical wave that is restricted to a specified solid angle, which is characteristic of radiation produced by a microwave or mm-wave antenna. The forest is modeled as a half-space of randomly distributed particles that scatter and absorb electromagnetic energy. In the forest, strong forward scattering occurs and the theory allows for a comprehensive characterization of the effect of vegetation on the propagation and scattering of spherical wave pulses: their attenuation, their angular spread, their distortion due to pulse broadening. C1 [Whitman, Gerald M.; Wu, Michael Y-C.] New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. [Schwering, Felix K.] USA, CECOM, Ft Monmouth, NJ 07703 USA. RP Whitman, GM (reprint author), New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. EM whitman@njit.edu; m@mikeywu.com; felix.schwering@us.army.mil NR 15 TC 0 Z9 0 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAY PY 2010 VL 58 IS 5 BP 1662 EP 1676 DI 10.1109/TAP.2010.2044311 PG 15 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 591XX UT WOS:000277339900025 ER PT J AU Sadler, BM Liu, N Xu, ZY AF Sadler, Brian M. Liu, Ning Xu, Zhengyuan TI Ziv-Zakai Bounds on Time Delay Estimation in Unknown Convolutive Random Channels SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE Bayesian estimation; convolutive fading channel; Cramer-Rao bound; error analysis; MAP estimation; MLE; time delay estimation; Ziv-Zakai bound ID SIGNAL PARAMETER-ESTIMATION; BANDWIDTH AB Using the Ziv-Zakai bound (ZZB) methodology, we develop a Bayesian mean-square error bound on time delay estimation (TDE) in convolutive random channels, and compare it with time delay estimator performance and a Cramer-Rao bound. The channel is modeled as a tapped delay line, whose taps are Gaussian random variables that may be nonzero mean and correlated, a model widely adopted in many applications such as wideband fading in a multipath channel. The time delay has a uniform prior distribution. A ZZB is developed that incorporates the prior on the random time delay, as well as the convolutive random Gaussian channel, and does not assume the receiver has knowledge of the channel realization. The ZZB provides good performance prediction for maximum a posteriori (MAP) time delay estimation, tracking the low, medium, and high signal-to-noise ratio (SNR) regimes. The convolutive channel model includes important special cases, such as narrowband Gaussian channels corresponding to Rayleigh/Rician fading, wideband multipath channels with a power decay profile (such as exponential decay), and known channels. We show that the associated Cramer-Rao bound is tight only at high SNR, whereas the ZZB predicts threshold behavior and TDE breakdown as the SNR decreases. When compared to a ZZB that assumes knowledge of the channel realization, the ZZB developed here provides a more realistic and tighter bound, revealing the performance loss due to lack of channel knowledge. The MAP estimator incorporates knowledge of the channel statistics, and so performs much better than a maximum likelihood estimator that minimizes mean square error but does not use knowledge of the random channel statistics. Several examples illustrate the estimator and bound behaviors. C1 [Sadler, Brian M.] USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA. [Liu, Ning; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. RP Sadler, BM (reprint author), USA, Res Lab, RDRL CIN T, Adelphi, MD 20783 USA. EM bsadler@arl.army.mil; dxu@ee.ucr.edu FU Army Research Laboratory CTA on Communications and Networks [DAAD19-01-2-0011] FX Manuscript received August 05, 2009; accepted December 18, 2009. Date of publication January 26, 2010; date of current version April 14, 2010. The associate editor coordinating the review of this manuscript and approving it for publication was Dr. Ali Ghrayeb. This work was supported in part by the Army Research Laboratory CTA on Communications and Networks under Grant DAAD19-01-2-0011. Some preliminary results were presented at the IEEE Sensor Array and Multichannel Signal Processing Workshop, Darmstadt, Germany, July 2008 [1]. NR 26 TC 8 Z9 8 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAY PY 2010 VL 58 IS 5 BP 2729 EP 2745 DI 10.1109/TSP.2010.2041379 PG 17 WC Engineering, Electrical & Electronic SC Engineering GA 583NX UT WOS:000276685600024 ER PT J AU Xu, JL Su, W Zhou, MC AF Xu, Jefferson L. Su, Wei Zhou, MengChu TI Software-Defined Radio Equipped With Rapid Modulation Recognition SO IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY LA English DT Article DE Adaptive modulation; cognitive radio (CR); maximum-likelihood ratio test; modulation classification; modulation recognition; parameter estimation; software-defined radio (SDR) ID MAXIMUM-LIKELIHOOD; CLASSIFICATION AB Automatic modulation recognition (AMR)-based software-defined radio (SDR) is a research challenge in developing third-generation (3G) and fourth-generation (4G) wireless communications with adaptive modulation capability. However, the existing AMR technology does not satisfy the seamless demodulation requirement of the SDR. A novel design of the AMR method with reduced computational complexity and fast processing speed is needed. This paper describes a discrete likelihood-ratio test (DLRT)-based rapid-estimation approach to identifying the modulation schemes blindly for uninterrupted data demodulation in real time. The statistical performance of the fast AMR associated with its implementation using the SDR is presented. C1 [Xu, Jefferson L.; Zhou, MengChu] New Jersey Inst Technol, Newark, NJ 07102 USA. [Su, Wei] USA, Commun Elect Res Dev & Engn Ctr, Ft Monmouth, NJ 07703 USA. [Zhou, MengChu] Xidian Univ, Sch Electromech Engn, Xian 710071, Peoples R China. RP Xu, JL (reprint author), New Jersey Inst Technol, Newark, NJ 07102 USA. EM jxuly@yahoo.com; wei.su@us.army.mil; zhou@njit.edu FU U.S. Department of Defense via Booz Allen Hamilton Inc.; National High Technology Research and Development (863) Program of China [2008AA04Z109]; Changjiang Scholars Program; Ministry of Education; PRC FX This work was supported in part by the U.S. Department of Defense via Booz Allen Hamilton Inc., in part by the National High Technology Research and Development (863) Program of China under Grant 2008AA04Z109, and in part by the Changjiang Scholars Program, Ministry of Education, PRC. The review of this paper was coordinated by Dr. O. Holland. NR 26 TC 38 Z9 41 U1 1 U2 12 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9545 J9 IEEE T VEH TECHNOL JI IEEE Trans. Veh. Technol. PD MAY PY 2010 VL 59 IS 4 BP 1659 EP 1667 DI 10.1109/TVT.2010.2041805 PG 9 WC Engineering, Electrical & Electronic; Telecommunications; Transportation Science & Technology SC Engineering; Telecommunications; Transportation GA 596CW UT WOS:000277662600009 ER PT J AU Sueker, JJ Blazes, DL Johns, MC Blair, PJ Sjoberg, PA Tjaden, JA Montgomery, JM Pavlin, JA Schnabel, DC Eick, AA Tobias, S Quintana, M Vest, KG Burke, RL Lindler, LE Mansfield, JL Erickson, RL Russell, KL Sanchez, JL AF Sueker, J. Jeremy Blazes, David L. Johns, Matthew C. Blair, Patrick J. Sjoberg, Paul A. Tjaden, Jeffrey A. Montgomery, Joel M. Pavlin, Julie A. Schnabel, David C. Eick, Angelia A. Tobias, Steven Quintana, Miguel Vest, Kelly G. Burke, Ronald L. Lindler, Luther E. Mansfield, Jay L. Erickson, Ralph Loren Russell, Kevin L. Sanchez, Jose L. CA DoD Influenza Working Grp TI Influenza and respiratory disease surveillance: the US military's global laboratory-based network SO INFLUENZA AND OTHER RESPIRATORY VIRUSES LA English DT Review DE Influenza; military; surveillance ID BASIC TRAINEES; VACCINES; ADENOVIRUS; PERSONNEL; SYSTEM AB The US Department of Defense influenza surveillance system now spans nearly 500 sites in 75 countries, including active duty US military and dependent populations as well as host-country civilian and military personnel. This system represents a major part of the US Government's contributions to the World Health Organization's Global Influenza Surveillance Network and addresses Presidential Directive NSTC-7 to expand global surveillance, training, research and response to emerging infectious disease threats. Since 2006, the system has expanded significantly in response to rising pandemic influenza concerns. The expanded system has played a critical role in the detection and monitoring of ongoing H5N1 outbreaks worldwide as well as in the initial detection of, and response to, the current (H1N1) 2009 influenza pandemic. This article describes the system, details its contributions and the critical gaps that it is filling, and discusses future plans. C1 [Sanchez, Jose L.] USAPHC Prov, Div GEIS Operat, AFHSC, Silver Spring, MD 20910 USA. [Blair, Patrick J.] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Tjaden, Jeffrey A.] US Naval Med Res Unit 3, Cairo, Egypt. [Montgomery, Joel M.] US Naval Med Res Ctr Detachment, Lima, Peru. [Pavlin, Julie A.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Schnabel, David C.] US Army Med Res Unit, Nairobi, Kenya. [Tobias, Steven] US Naval Med Res Unit 2, Jakarta, Indonesia. [Sjoberg, Paul A.] USAF, Sch Aerosp Med, Brooks City Base, TX USA. RP Sanchez, JL (reprint author), USAPHC Prov, Div GEIS Operat, AFHSC, 2900 Linden Lane,Suite 100, Silver Spring, MD 20910 USA. EM toti.sanchez@us.army.mil RI Valle, Ruben/A-7512-2013; Bulimo, Wallace/B-1982-2014 OI Bulimo, Wallace/0000-0001-8475-0586 FU DoD Global Emerging Surveillance and Response System (DoD-GEIS); Armed Forces Health Surveillance Center (AFHSC) FX This study was supported by the US Military's Defense Health Program funding of the DoD Global Emerging Surveillance and Response System (DoD-GEIS) and the Armed Forces Health Surveillance Center (AFHSC). NR 31 TC 13 Z9 13 U1 0 U2 6 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1750-2640 J9 INFLUENZA OTHER RESP JI Influenza Other Respir. Viruses PD MAY PY 2010 VL 4 IS 3 BP 155 EP 161 DI 10.1111/j.1750-2659.2010.00129.x PG 7 WC Infectious Diseases; Virology SC Infectious Diseases; Virology GA 579GF UT WOS:000276356100007 ER PT J AU Tran, DT Chu, D Oliver, AG Oliver, SRJ AF Tran, Dat T. Chu, Deryn Oliver, Allen G. Oliver, Scott R. J. TI A 3-D lanthanum-organic framework containing double chains: La-2[NC5H3(CO2)(2)](3)center dot 3H(2)O SO INORGANIC CHEMISTRY COMMUNICATIONS LA English DT Article DE Hydrothermal synthesis; 3,5-Pyridinedicarboxylate; Lanthanum; Metal-organic framework; Zig-zag chains; Double chains ID LIGAND; DIVERSITY; SERIES AB A three-dimensional La(III) based metal-organic framework, La-2[NC5H3(CO2)(2)](3)center dot 3H(2)O, was assembled using the aromatic linker 3.5-pyridinedicarboxylate. This new compound was synthesized hydrothermally and is an unusual example of a lanthanum containing metal-organic network. The compound contains two distinct La centers, each adopting a nine-coordinate geometry. The structure is built up from zig-zag chains that link via bridging water molecules into a double chain defining edge-sharing six rings. These double chains are arranged into layers and connect through 3,5-pyridinedicarboxylate ligands to give the extended 3-D coordination framework. The material is thermally stable to ca. 360 degrees C and transforms to an unknown compound before finally decomposing to phase-pure La2O3 at 800 degrees C. The synthesis, structure, morphology and properties of the new material are described. Published by Elsevier B.V. C1 [Tran, Dat T.; Chu, Deryn] USA, Res Lab, Adelphi, MD 20783 USA. [Oliver, Allen G.; Oliver, Scott R. J.] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA. RP Tran, DT (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM dat.tran1@arl.army.mil FU Army Research Laboratory; NSF [DMR-0506279]; U.S. Department of Energy, Office of Energy Sciences [DE-AC02-05CH11231] FX The Army Research Laboratory is acknowledged for financial support of this research. S.O. acknowledges financial support from an NSF Career Award (DMR-0506279). Samples for synchrotron crystallographic analysis were submitted through the SCrALS (Service Crystallography at Advanced Light Source) program. The ALS is supported by the U.S. Department of Energy, Office of Energy Sciences, under contract DE-AC02-05CH11231. NR 34 TC 3 Z9 3 U1 4 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1387-7003 J9 INORG CHEM COMMUN JI Inorg. Chem. Commun. PD MAY PY 2010 VL 13 IS 5 BP 649 EP 652 DI 10.1016/j.inoche.2010.03.010 PG 4 WC Chemistry, Inorganic & Nuclear SC Chemistry GA 603UW UT WOS:000278234600020 ER PT J AU Clayton, JD AF Clayton, J. D. TI Deformation, fracture, and fragmentation in brittle geologic solids SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article DE Micromechanics; Crystal plasticity; Fracture; Fragmentation; Rock; Granite ID DYNAMIC FRAGMENTATION; MECHANICAL-PROPERTIES; TRIAXIAL COMPRESSION; CRYSTAL PLASTICITY; VISCOPLASTIC MODEL; VARIABLE FRICTION; ELASTIC-CONSTANTS; GRANITIC-ROCKS; FINITE STRAIN; DAMAGE AB A model is developed for mechanical behavior and failure of brittle solids of geologic origin. Mechanisms considered include elastic stretch and rotation, thermal expansion, and deformation associated with micro-cracks. Decohesion on preferred cleavage planes in the solid, and subsequent effects of crack opening and sliding, are modeled. Explicit volume averaging over an element of material containing displacement discontinuities, in conjunction with the generalized divergence theorem, leads to an additive decomposition of the deformation gradient into contributions from thermoelasticity in the intact material and displacement jumps across micro-cracks. This additive decomposition is converted into a multiplicative decomposition, and the inelastic velocity gradient is then derived in terms of rates of crack extension, opening, and sliding on discrete planes in the microstructure. Elastic nonlinearity at high pressures, elastic moduli degradation from micro-cracking, dilatancy, pressure- and strain rate-sensitive yield, and energy dissipation from crack growth and sliding are formally addressed. Densities of micro-cracks are treated as internal state variables affecting the free energy of the solid. The mean fragment size of particles of failed material arises from geometric arguments in terms of the evolving average crack radius and crack density, with smaller fragments favored at higher loading rates. The model is applied to study granite, a hard polycrystalline rock, under various loading regimes. Dynamic stress-strain behavior and mean fragment sizes of failed material are realistically modeled. Possible inelastic anisotropy can be described naturally via prescription of cleavage planes of varying strengths. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Clayton, JD (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jclayton@arl.army.mil RI Clayton, John/C-7760-2009 NR 74 TC 23 Z9 24 U1 0 U2 19 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD MAY PY 2010 VL 163 IS 1-2 SI SI BP 151 EP 172 DI 10.1007/s10704-009-9409-5 PG 22 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA 612JI UT WOS:000278893500011 ER PT J AU Wang, YQ Miao, YY Swenson, D Cheeseman, BA Yen, CF LaMattina, B AF Wang, Youqi Miao, Yuyang Swenson, Daniel Cheeseman, Bryan A. Yen, Chian-Feng LaMattina, Bruce TI Digital element approach for simulating impact and penetration of textiles SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE High speed penetration; Digital element simulation; Ballistic resistance; Fabrics; Body armor ID BALLISTIC IMPACT; WOVEN FABRICS; FRICTION; PROJECTILE; BEHAVIOR; ARMOR; FIBER; MODEL AB A micro-scale computational tool, based upon an explicit digital element method (DEM), has been developed for numerical simulation of ballistic impact and penetration of textile fabrics. In this approach, each yarn is digitized as an assembly of digital fibers. Each digital fiber is further digitized into a short digital rod element chain connected by frictionless pins (nodes). A search is conducted to find contacts between adjacent digital fibers. If a contact is detected, compressive and frictional forces between fibers will be determined, based upon contact stiffness and friction coefficient. Nodal forces are calculated for each time step. Nodal displacements are determined using an explicit procedure. Because the digital element approach operates on a sub-yarn micro-scale, one can determine textile penetration resistance based upon sub-yarn scale properties, such as inter-fiber compression, friction, and fiber strength. Research presented in this paper includes three parts. First, the explicit digital element algorithm used in dynamic simulation is explained. Second, the approach is used to generate 2-D woven fabric micro-geometries and to simulate ballistic penetration processes. Third, numerical results are compared to high resolution experimental impact and ballistic test data. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Wang, Youqi; Miao, Yuyang; Swenson, Daniel] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. [Cheeseman, Bryan A.; Yen, Chian-Feng] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [LaMattina, Bruce] USA, Res Off, Durham, NC 27703 USA. RP Wang, YQ (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA. EM wang@mne.ksu.edu FU Army Research Laboratory and Army Research Office FX The authors would like to acknowledge the Army Research Laboratory and Army Research Office for their financial support. NR 35 TC 25 Z9 25 U1 1 U2 13 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAY PY 2010 VL 37 IS 5 BP 552 EP 560 DI 10.1016/j.ijimpeng.2009.10.009 PG 9 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 569QS UT WOS:000275614400009 ER PT J AU Killgore, WDS Killgore, DB Grugle, NL Balkin, TJ AF Killgore, William D. S. Killgore, Desiree B. Grugle, Nancy L. Balkin, Thomas J. TI Odor Identification Ability Predicts Executive Function Deficits Following Sleep Deprivation SO INTERNATIONAL JOURNAL OF NEUROSCIENCE LA English DT Article ID CARD SORTING TEST; FRONTAL-LOBE FUNCTION; PSYCHOMOTOR VIGILANCE; DECISION-MAKING; INDIVIDUAL-DIFFERENCES; NEURAL BASIS; 2 NIGHTS; PERFORMANCE; CAFFEINE; SCHIZOPHRENIA AB Odor identification ability is sensitive to prefrontal lobe dysfunction and preliminary evidence suggests that this capacity may decline with prolonged wakefulness. We hypothesized that declines in odor identification during a single night of sleep loss might, therefore, be predictive of prefrontal lobe executive function deficits following an additional night of sleep deprivation. Change scores between two administrations of the University of Pennsylvania Smell Identification Test (SIT) during 24 hr of sleep deprivation were used to predict performance on the Wisconsin Card Sorting Test (WCST) following 45 hr of wakefulness in 54 healthy adults. Declines in SIT performance predicted poorer performance on the WCST following an additional night of sleep loss. These findings suggest that individual differences in vulnerability to the effects of sleep loss on odor identification ability are predictive of deficits in executive functioning following additional wakefulness. Odor identification ability may provide an unobtrusive method for assessing vulnerability to sleep deprivation. C1 [Killgore, William D. S.; Killgore, Desiree B.; Grugle, Nancy L.; Balkin, Thomas J.] Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Behav Biol, Div Psychiat & Neurosci, Washington, DC 20307 USA. RP Killgore, WDS (reprint author), McLean Hosp, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 58 TC 6 Z9 6 U1 0 U2 2 PU INFORMA HEALTHCARE PI LONDON PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND SN 0020-7454 J9 INT J NEUROSCI JI Int. J. Neurosci. PD MAY PY 2010 VL 120 IS 5 BP 328 EP 334 DI 10.3109/00207450903389396 PG 7 WC Neurosciences SC Neurosciences & Neurology GA 585HG UT WOS:000276815100002 PM 20402570 ER PT J AU McDowall, NB Wilkins, JR Carroll, KJ Edwards, JD Nelson, JD Carpenter, EE Glaspell, GP AF McDowall, Nicholas B. Wilkins, James R. Carroll, Kyler J. Edwards, Jarrod D. Nelson, Jean D. Carpenter, Everett E. Glaspell, Garry P. TI Spectrally tunable magnetic nanoparticles designed for distribution/recollection applications SO JOURNAL OF APPLIED PHYSICS LA English DT Article; Proceedings Paper CT 11th Joint MMM-Intermag Conference CY JAN 18-22, 2010 CL Washington, DC ID MULTIFUNCTIONAL NANOSTRUCTURES; NANOCRYSTALS; LUMINESCENCE; LN AB The comprehensive goal of this research is the synthesis and characterization of nanomaterials that are spectrally tunable in terms of their electromagnetic signal, are robust, magnetic (allowing their piloted movement), and have the potential to be functionalized for the detection of CBRNE threats. Various chemical methods were utilized for synthesis of magnetic (iron) and luminescent rare earth (RE) components, and their mixtures. Effects of integrating an iron core into RE luminescent lattices (excited by UV, emit in the VIS) were investigated. The determination of the optimum balances between magnetic and luminescent components such that the magnetism was maximized while maintaining acceptable fluorescence integrity will be discussed. The emphasis of this work is focused on developing a distributed sensor suitable for use in the terrestrial environment. The robust properties of using a RE luminescent shell would allow the particles to be resistant to photobleaching. Additionally the chemical stability of the RE shell would allow operation in a variety of pH conditions. The magnetic core will ultimately allow the distributed particles to be recollected. [doi:10.1063/1.3355900] C1 [McDowall, Nicholas B.; Wilkins, James R.; Carroll, Kyler J.; Nelson, Jean D.; Glaspell, Garry P.] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA. [McDowall, Nicholas B.; Wilkins, James R.; Edwards, Jarrod D.; Nelson, Jean D.; Carpenter, Everett E.; Glaspell, Garry P.] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Glaspell, GP (reprint author), Virginia Commonwealth Univ, Dept Chem, Box 2006, Richmond, VA 23284 USA. EM garry.p.glaspell@us.army.mil RI Carpenter, Everett/A-2797-2010; Carroll, Kyler/F-3932-2011 OI Carpenter, Everett/0000-0002-3497-0318; Carroll, Kyler/0000-0002-6259-7290 NR 20 TC 2 Z9 2 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 2010 VL 107 IS 9 AR 09B327 DI 10.1063/1.3355900 PG 3 WC Physics, Applied SC Physics GA 598KC UT WOS:000277834300203 ER PT J AU Weingarten, NS Mattson, WD Yau, AD Weihs, TP Rice, BM AF Weingarten, N. Scott Mattson, William D. Yau, Anthony D. Weihs, Timothy P. Rice, Betsy M. TI A molecular dynamics study of the role of pressure on the response of reactive materials to thermal initiation SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SOLID-STATE REACTIONS; AL/NI MULTILAYERS; PHASE-FORMATION; FILMS AB To elucidate the mechanisms of energy release in a reacting nickel/aluminum bilayer, we simulate the exothermic alloying reactions using both microcanonical and isoenthalpic- isobaric molecular dynamics simulations and an embedded-atom method type potential. The mechanism of the mixing consists of a sequence of steps in which mixing and reaction first occurs at the interface; the resulting heat generated from the mixing then melts the Al layer; subsequent mixing leads to further heat generation after which the Ni layer melts. The mixing continues until the alloying reactions are completed. The results indicate that pressure has a significant influence on the rates of atomic mixing and alloying reactions. Local pressures and temperatures within the individual layers at the time of melting are calculated, and these results are compared with the pressure-dependent melting curves determined for pure Al and pure Ni using this interaction potential. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3340965] C1 [Weingarten, N. Scott; Mattson, William D.; Yau, Anthony D.; Rice, Betsy M.] USA, Res Lab, RDRL WML B, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Yau, Anthony D.] High Performance Technol Inc, Reston, VA 20190 USA. [Weihs, Timothy P.] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. RP Weingarten, NS (reprint author), USA, Res Lab, RDRL WML B, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM scott.weingarten@arl.army.mil RI Weihs, Timothy/A-3313-2010 NR 22 TC 24 Z9 24 U1 2 U2 13 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 2010 VL 107 IS 9 AR 093517 DI 10.1063/1.3340965 PG 10 WC Physics, Applied SC Physics GA 598KC UT WOS:000277834300452 ER PT J AU Griffith, J AF Griffith, James TI When Does Soldier Patriotism or Nationalism Matter? The Role of Transformational Small-Unit Leaders SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY LA English DT Article ID ISRAELI SOLDIERS; MOTIVATION; MILITARY; IDENTITY; MOTIVES; ENLIST; COMBAT AB Patriotism and nationalism, 2 sets of attitudes often associated with the military, are examined in relation to perceived combat readiness and intention to remain in military service. Transformational leadership served as an intervening variable in these relationships. Survey data obtained from a sample of Army National Guard soldiers (N = 415) were used to examine relationships. Among junior-ranking enlisted soldiers, both patriotism and nationalism showed significant, positive associations with perceived combat readiness and intention to remain in military service. The structural equation model fit soldiers' nationalistic attitudes best, having a considerable indirect effect through transformational leadership on perceived combat readiness. Implications of nationalistic and patriotic attitudes combined with charismatic leaders to benefit soldier readiness and retention are discussed. C1 [Griffith, James] US Army Natl Guard, Baltimore, MD USA. RP Griffith, J (reprint author), 10956 Bellehaven Blvd, Damascus, MD 20872 USA. EM GriffithJH@verizon.net NR 60 TC 3 Z9 3 U1 3 U2 10 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0021-9029 J9 J APPL SOC PSYCHOL JI J. Appl. Soc. Psychol. PD MAY PY 2010 VL 40 IS 5 BP 1235 EP 1257 PG 23 WC Psychology, Social SC Psychology GA 598NG UT WOS:000277843900010 ER PT J AU Cameron, KL Duffey, ML DeBerardino, TM Stoneman, PD Jones, CJ Owens, BD AF Cameron, Kenneth L. Duffey, Michele L. DeBerardino, Thomas M. Stoneman, Paul D. Jones, Christopher J. Owens, Brett D. TI Association of Generalized Joint Hypermobility With a History of Glenohumeral Joint Instability SO JOURNAL OF ATHLETIC TRAINING LA English DT Article DE military athletes; sex differences; joint injuries; shoulder injuries ID INFERIOR CAPSULAR-SHIFT; MULTIDIRECTIONAL INSTABILITY; SHOULDER DISLOCATION; LAXITY; PREVALENCE; PATTERNS; RISK; POPULATION; MOBILITY; STUDENTS AB Context: Little is known about the relationship among sex, generalized joint hypermobility, and glenohumeral joint instability. Objective: To examine the relationship among sex, generalized joint hypermobility scores, and a history of glenohumeral joint instability within a young, physically active cohort and to describe the incidence of generalized joint hypermobility within this population. Design: Cross-sectional cohort study. Setting: United States Military Academy at West Point, New York. Patients or Other Participants: Of the 1311 members of the entering freshman class of 2010, 1050 (80%) agreed to participate. Main Outcome Measure(s): Generalized joint hypermobility was assessed using the Beighton Scale. A history of glenohumeral joint instability was identified via a baseline questionnaire. Results: Most participants (78%) had no signs of generalized joint hypermobility. Only 11 volunteers (1.5%) had Beighton Scale scores of 4 or greater. Logistic regression analysis revealed a relationship between generalized joint hypermobility and a history of glenohumeral joint instability (P = .023). When sex and race were controlled, those with a total Beighton Scale score of >= 2 were nearly 2.5 times as likely (odds ratio = 2.48, 95% confidence interval = 1.19, 5.20, P = .016) to have reported a history of glenohumeral joint instability. A relationship was observed between sex and nearly all individual Beighton Scale items. Although women had higher total Beighton Scale scores than men, sex (P = .658) and race (P = .410) were not related to a history of glenohumeral joint instability when other variables in the model were controlled. Conclusions: In these participants, generalized joint hypermobility and a history of glenohumeral joint instability were associated. C1 [Cameron, Kenneth L.; DeBerardino, Thomas M.; Stoneman, Paul D.; Owens, Brett D.] Keller Army Hosp, Dept Orthopaed Surg & Phys Therapy, West Point, NY 10996 USA. [Duffey, Michele L.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. [Jones, Christopher J.] Penn State Univ, Dept Kinesiol, State Coll, PA USA. RP Cameron, KL (reprint author), Keller Army Hosp, Dept Orthopaed Surg & Phys Therapy, 900 Washington Rd, West Point, NY 10996 USA. EM kenneth.cameron@amedd.army.mil OI DeBerardino, Thomas/0000-0002-7110-8743 FU Orthopaedic Research and Education Foundation FX This project was aided by a grant from the Orthopaedic Research and Education Foundation. We thank Sally Mountcastle, PhD, for her assistance with the conception and design of this project. We also thank Tim Kelly, ATC, and Dana Putnam, ATC (Department of Intercollegiate Athletics); Craig Yunker, ATC, Karen Peck, ATC, and Jason Suby, ATC (Department of Physical Education), at the United States Military Academy; and William Loro, DPT, DSc, ATC, SCS; Mark Thelen, DPT; James Dauber, DPT; and Heath Todd, PT, in the Physical Therapy Department at the Keller Army Hospital for their assistance with the logistics, baseline data collection, and ongoing injury surveillance for this project. In addition, we recognize and thank the members of the United States Military Academy graduating class of 2010 for their participation in this study and their commitment to serve our nation. The views and opinions expressed in this manuscript are those of the author(s) and do not reflect the official policy of the Department of the Army, the Department of Defense, or the US Government. NR 35 TC 27 Z9 27 U1 1 U2 9 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD MAY-JUN PY 2010 VL 45 IS 3 BP 253 EP 258 DI 10.4085/1062-6050-45.3.253 PG 6 WC Sport Sciences SC Sport Sciences GA 599PI UT WOS:000277925200007 PM 20446838 ER PT J AU Yun, JI Wikesjo, UME Borke, JL Bisch, FC Lewis, JE Herold, RW Swiec, GD Wood, JC McPherson, JC AF Yun, Jonathan I. Wikesjoe, Ulf M. E. Borke, James L. Bisch, Frederick C. Lewis, Jill E. Herold, Robert W. Swiec, Gary D. Wood, Joseph C. McPherson, James C., III TI Effect of systemic parathyroid hormone (1-34) and a beta-tricalcium phosphate biomaterial on local bone formation in a critical-size rat calvarial defect model SO JOURNAL OF CLINICAL PERIODONTOLOGY LA English DT Article DE beta-tricalcium phosphate; guided bone regeneration; parathyroid hormone; rat calvaria model; tissue engineering ID MORPHOGENETIC PROTEIN-4; REGENERATION; APOPTOSIS; SURGERY; MATRIX; DRUG AB P>Objective The objective of this study was to evaluate local bone formation following systemic administration of parathyroid hormone (1-34) (PTH), a surgically implanted synthetic beta-tricalcium phosphate (beta-TCP) bone biomaterial serving as a matrix to support new bone formation. Materials and Methods Critical-size, 8 mm, calvarial through-and-through osteotomy defects were surgically created in 100 adult male Sprague-Dawley rats. The animals were randomized into five groups of 20 animals each to receive one of the following treatments: PTH (15 mu g PTH/kg/day; subcutaneously), PTH/beta-TCP, beta-TCP, or particulate human demineralized freeze-dried bone (DFDB), and sham-surgery controls. Ten animals/group were euthanized at 4 and 8 weeks post-surgery for radiographic and histometric analysis. Results The histometric analysis showed that systemic PTH significantly enhanced local bone formation, bone fill averaging (+/- SE) 32.2 +/- 4.0% compared with PTH/beta-TCP (15.7 +/- 2.4%), beta-TCP (12.5 +/- 2.3%), DFDB (14.5 +/- 2.3%), and sham-surgery control (10.0 +/- 1.5%) at 4 weeks (p < 0.014). Systemic PTH showed significantly enhanced bone formation (41.5 +/- 4.0%) compared with PTH/beta-TCP (22.4 +/- 3.0%), beta-TCP (21.3 +/- 4.4%), and with the sham-surgery control (23.8 +/- 4.2%) at 8 weeks (p < 0.025). The DFDB group showed significantly increased bone formation from 4 (14.5 +/- 2.3%) to 8 weeks (32.0 +/- 3.2%) (p < 0.006). The PTH/beta-TCP and beta-TCP groups both showed limited biomaterials resorption. The radiographic analysis was not diagnostic to distinguish local bone formation from the radiopaque beta-TCP biomaterial. Conclusions Systemic administration of PTH significantly stimulates local bone formation. Bone formation was significantly limited by the beta-TCP biomaterial. C1 [Yun, Jonathan I.; Bisch, Frederick C.; Herold, Robert W.] US Army, Adv Educ Program Periodont, Ft Gordon, GA USA. [Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, LAPCR, Dept Periodont, Augusta, GA 30912 USA. [Wikesjoe, Ulf M. E.] Med Coll Georgia, Sch Dent, LAPCR, Dept Oral Biol, Augusta, GA 30912 USA. [Swiec, Gary D.] USA, DENTAC, Ft George G Meade, MD USA. [Wood, Joseph C.; McPherson, James C., III] US Army, Dept Clin Invest, Ft Gordon, GA USA. RP Yun, JI (reprint author), 851 Ted A Crozier Sr,Blvd Apt 711, Clarksville, TN 37043 USA. EM jonathan.yun@us.army.mil RI Wikesjo, Ulf/A-4159-2009 OI Wikesjo, Ulf/0000-0003-1607-0583 FU USA DENTAC, Fort Gordon, GA FX The study was funded in its entirety by the USA DENTAC, Fort Gordon, GA. NR 27 TC 25 Z9 25 U1 2 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6979 J9 J CLIN PERIODONTOL JI J. Clin. Periodontol. PD MAY PY 2010 VL 37 IS 5 BP 419 EP 426 DI 10.1111/j.1600-051X.2010.01547.x PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 580ZP UT WOS:000276490000003 PM 20236187 ER PT J AU Baird, D Bush, RJ Seehusen, D Usatine, RP AF Baird, Drew Bush, Robert Joel Seehusen, Dean Usatine, Richard P. TI Diffuse rash and cough in elderly woman with a UTI SO JOURNAL OF FAMILY PRACTICE LA English DT Editorial Material ID LUNG-DISEASE; NITROFURANTOIN C1 [Baird, Drew; Bush, Robert Joel; Seehusen, Dean] Army Med Ctr, Ft Gordon, GA USA. [Usatine, Richard P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. RP Baird, D (reprint author), Army Med Ctr, Ft Gordon, GA USA. EM drew.baird@us.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU DOWDEN HEALTH MEDIA PI MONTVALE PA 110 SUMMIT AVE, MONTVALE, NJ 07645-1712 USA SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD MAY PY 2010 VL 59 IS 5 BP 281 EP 284 PG 3 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 796XP UT WOS:000293087100012 PM 20544049 ER PT J AU Fehlman, WL Hinders, MK AF Fehlman, William L., II Hinders, Mark K. TI Passive Infrared Thermographic Imaging for Mobile Robot Object Identification SO JOURNAL OF FIELD ROBOTICS LA English DT Article ID FOURIER-MELLIN DESCRIPTORS; INVARIANT PATTERN-RECOGNITION; MOMENT INVARIANTS; TERRAIN CLASSIFICATION; MATHEMATICAL-THEORY; TEXTURAL FEATURES; EMISSIVITY; IMAGES; DISCRIMINATION; COMMUNICATION AB The usefulness of thermal infrared imaging as a mobile robot sensing modality is explored, and a set of thermal physical features used to characterize passive thermal objects in outdoor environments is described. Objects that extend laterally beyond the thermal camera's field of view, such as brick walls, hedges, picket fences, and wood walls, as well as compact objects that are laterally within the thermal camera's field of view, such as metal poles and tree trunks, are considered. Classification of passive thermal objects is a subtle process because they are not a source for their own emission of thermal energy. A detailed analysis is included of the acquisition and preprocessing of thermal images, as well as the generation and selection of thermal physical features from these objects within thermal images. Classification performance using these features is discussed, as a precursor to the design of a physics-based model to automatically classify these objects. Published 2009 Wiley Periodicals, Inc.* C1 [Fehlman, William L., II] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Hinders, Mark K.] Coll William & Mary Virginia, NDE Lab, Williamsburg, VA 23187 USA. RP Fehlman, WL (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM William.Fehlman@usma.edu; hinders@wm.edu FU General Omar N. Bradley Research FX The authors would like to thank Cara Campbell and Danielle Dumond for assisting in capturing thermal images of objects during extreme environmental conditions. Thanks to Jonathan Stevens for his technical expertise in designing and constructing rMary. Partial support for this work was provided by a General Omar N. Bradley Research Fellowship in Mathematics. NR 78 TC 1 Z9 1 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1556-4959 EI 1556-4967 J9 J FIELD ROBOT JI J. Field Robot. PD MAY-JUN PY 2010 VL 27 IS 3 BP 281 EP 310 DI 10.1002/rob.20307 PG 30 WC Robotics SC Robotics GA 585WV UT WOS:000276862000004 ER PT J AU Yeh, PH Oakes, T Graner, J Wang, B Pai, H Munter, F AF Yeh, P. H. Oakes, T. Graner, J. Wang, B. Pai, H. Munter, F. TI Multi-Modal Molecular Imaging for Mild Traumatic Brain Injury SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract CT Molecular Neuroimaging Symposium CY MAY 06-07, 2010 CL NIH, Bethesda, MD HO NIH C1 [Yeh, P. H.; Oakes, T.; Graner, J.; Wang, B.; Pai, H.] Henry Jackson Fdn Mil Med, Rockville, MD USA. [Munter, F.] Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Natl Capital Neuroimaging Consortium, Dept Radiol, Washington, DC USA. [Munter, F.] Uniformed Serv Univ Hlth Sci, Dept Radiol Sci, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD MAY 1 PY 2010 VL 51 IS 5 MA 19 BP 833 EP 833 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 590PL UT WOS:000277239000050 ER PT J AU Gill, NW Rendeiro, DG AF Gill, Norman W. Rendeiro, Daniel G. TI Hook of the Hamate Fracture SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material C1 [Gill, Norman W.] Brooke Army Med Ctr, San Antonio, TX USA. [Rendeiro, Daniel G.] Darnall Army Med Ctr, Phys Therapy Serv, Ft Hood, TX USA. RP Gill, NW (reprint author), Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 2010 VL 40 IS 5 BP 325 EP 325 DI 10.2519/jospt.2010.0408 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 595AR UT WOS:000277583600010 PM 20436245 ER PT J AU Brechue, WF Mayhew, JL Piper, FC AF Brechue, William F. Mayhew, Jerry L. Piper, Fontaine C. TI CHARACTERISTICS OF SPRINT PERFORMANCE IN COLLEGE FOOTBALL PLAYERS SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH LA English DT Article DE 40-yd sprint; body mass; acceleration; muscular strength; muscular power; performance ID NCAA DIVISION-I; PHYSICAL-CHARACTERISTICS; RUNNING SPEED; STRENGTH; POWER; BASKETBALL; ABILITY; MUSCLE AB Brechue, WF, Mayhew, JL, and Piper, FC. Characteristics of sprint performance in college football players. J Strength Cond Res 24(5): 1169-1178, 2010-To investigate sprinting strategy, acceleration and velocity patterns were determined in college football players (n = 61) during performance of a 9.1-, 36.6-, and 54.9-m sprints. Acceleration and velocity were determined at 9.1-m intervals during each sprint. Lower-body strength and power were evaluated by 1 repetition maximum (1-RM) squat, power clean, jerk, vertical jump, standing long jump, and standing triple jump. Sprint times averaged 1.78 +/- 0.11 seconds (9.1 m), 5.18 +/- 0.35 seconds (36.6 m), and 7.40 +/- 0.53 seconds. Acceleration peaked at 9.1 m (2.96 +/- 0.44 m.s(-2)), was held constant at 18.3 m (3.55 +/- 0.0.94 m.s(-2)), and was negative at 27.4 m (-1.02 +/- 0.72 m.s(-2)). Velocity peaked at 18.3 m (8.38 +/- 0.65 m.s(-1)) and decreased slightly, but significantly at 27.4 m (7.55 +/- 0.66 m.s(-1)), associated with the negative acceleration. Measures of lower-body strength were significantly related to acceleration, velocity, and sprint performance only when corrected for body mass. Lower-body strength/BM and power correlated highest with 36.6-m time (rs = -0.55 to -0.80) and with acceleration (strength r = 0.67-0.49; power r = 0.73-0.81) and velocity (strength r = 0.68-0.53; power r = 0.74-0.82) at 9.1 m. Sprint times and strength per body mass were significantly lower in lineman compared with linebackers-tight ends and backs. The acceleration and velocity patterns were the same for each position group, and differences in sprint time were determined by the magnitude of acceleration and velocity at 9.1 and 18.3 m. Sprint performance in football players is determined by a rapid increase in acceleration (through 18.3 m) and a high velocity maintained throughout the sprint and is independent of position played. The best sprint performances (independent of sprint distance) appear to be related to the highest initial acceleration (through 18.3 m) and highest attained and maintained velocity. Strength relative to body mass and power appears to impact initial acceleration and velocity (through 18.3 m) in contribution to sprint performance. C1 [Brechue, William F.] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Mayhew, Jerry L.; Piper, Fontaine C.] Truman State Univ, Human Performance Lab, Kirksville, MO USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Dept Physiol, Kirksville, MO USA. [Piper, Fontaine C.] AT Still Univ Hlth Sci, Dept Anat, Kirksville, MO USA. RP Brechue, WF (reprint author), US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. EM bill.brechue@usma.edu NR 31 TC 26 Z9 27 U1 3 U2 25 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD MAY PY 2010 VL 24 IS 5 BP 1169 EP 1178 DI 10.1519/JSC.0b013e3181d68107 PG 10 WC Sport Sciences SC Sport Sciences GA 595KB UT WOS:000277608000002 PM 20386124 ER PT J AU Goldin, SB Wahi, MM AF Goldin, Steven B. Wahi, Monika M. TI Response to Letter "Quality of Life is Not Quality of Clerkship" SO JOURNAL OF SURGICAL RESEARCH LA English DT Editorial Material ID GENERAL-SURGERY; SURGICAL CLERKSHIP; MEDICAL-STUDENTS; CAREER; STYLE C1 [Goldin, Steven B.] Univ S Florida, Coll Med, Tampa, FL 33620 USA. [Wahi, Monika M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Goldin, SB (reprint author), Univ S Florida, Coll Med, Tampa, FL 33620 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0022-4804 J9 J SURG RES JI J. Surg. Res. PD MAY 1 PY 2010 VL 160 IS 1 BP 64 EP 66 DI 10.1016/j.jss.2008.12.011 PG 3 WC Surgery SC Surgery GA 581YU UT WOS:000276562700014 PM 19467670 ER PT J AU McCaslin, DL Jacobson, GP Burrows, HL Littlefield, P Haynes, DS AF McCaslin, Devin L. Jacobson, Gary P. Burrows, Holly L. Littlefield, Philip Haynes, David S. TI Transforming Superior Canal Dehiscence to Chronic Subjective Dizziness: From SCD to CSD SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE Chronic subjective dizziness; superior canal dehiscence; vestibular ID EVOKED MYOGENIC POTENTIALS; CONDUCTIVE HEARING-LOSS; ANXIETY; VERTIGO AB Patients presenting with chronic dizziness and no identifiable vestibular impairments have been described as having "extravestibular" symptoms, or "psychogenic dizziness." In 2005, Staab and Ruckenstein described a syndrome they referred to as "chronic subjective dizziness" (CSD), which characterized this concept more clearly. According to Staab and Ruckenstein (2003), the primary physical symptoms of CSD are continual nonvertiginous dizziness or subjective imbalance that persists for 3 moor longer. Patients suffering from CSD often describe their dizziness as a rocking or swaying when sitting or standing. This case study describes a 41-yr-old female who originally presented with complaints of noise-induced vertigo. The patient's history, imaging studies, and balance function examinations led to the diagnosis of a right-sided superior canal dehiscence (SCD). After surgical repair of the dehiscence, the quantitative electrophysiological tests returned to normal. However, the patient's scores on measures of anxiety, depression, and self-perceived dizziness handicap increased significantly postoperatively. This case illustrates the transformation of a peripheral end-organ impairment (i.e., SOD) into a psychiatric condition (i.e., CSD). C1 [McCaslin, Devin L.; Jacobson, Gary P.; Haynes, David S.] Vanderbilt Univ, Dept Hearing & Speech Sci, Vanderbilt Bill Wilkerson Ctr Otolaryngol & Commu, Nashville, TN USA. [Burrows, Holly L.] Walter Reed Army Med Ctr, Army Audiol Clin, Washington, DC 20307 USA. [Littlefield, Philip] Walter Reed Army Med Ctr, Army Otolaryngol Clin, Washington, DC 20307 USA. RP McCaslin, DL (reprint author), Div Audiol, Med Ctr E,S Tower,1215 21st Ave S,Ste 9302, Nashville, TN 37232 USA. EM devin.mccaslin@vanderbilt.edu OI Littlefield, Philip/0000-0002-1890-2278 NR 19 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD MAY PY 2010 VL 21 IS 5 BP 293 EP 300 DI 10.3766/jaaa.21.5.2 PG 8 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 615MH UT WOS:000279138900002 PM 20569664 ER PT J AU Baird, D Bode, D Akers, T DeYoung, Z AF Baird, Drew Bode, David Akers, Troy DeYoung, Zachariah TI Elephantiasis Nostras Verrucosa (ENV): A Complication of Congestive Heart Failure and Obesity SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Article DE Elephantiasis; Congestive Heart Failure; Obesity; Lymphedema; Case Report ID LYMPHEDEMA; DIAGNOSIS; LESIONS; SKIN AB Congestive heart failure (CHF) and obesity are common medical conditions that have many complications and an increasing incidence in the United States. Presented here is a case of a disfiguring skin condition that visually highlights the dermatologic consequences of poorly controlled CHF and obesity. This condition will probably become more common as CHF and obesity increase in the US. (J Am Board Fam Med 2010;23:413-417.) C1 [Baird, Drew; Bode, David; Akers, Troy; DeYoung, Zachariah] Dwight D Eisenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. RP Baird, D (reprint author), Carl R Darnall Army Med Ctr, Dept Family & Community Med, 36000 Darnall Loop, Ft Hood, TX 76544 USA. EM drew.baird@us.army.mil NR 14 TC 6 Z9 6 U1 0 U2 3 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD MAY-JUN PY 2010 VL 23 IS 3 BP 413 EP 417 DI 10.3122/jabfm.2010.03.090139 PG 5 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 592OZ UT WOS:000277390200017 PM 20453188 ER PT J AU Wereszczak, AA Harper, DC Duty, CE Patel, P AF Wereszczak, Andrew A. Harper, David C. Duty, Chad E. Patel, Parimal TI Glass Strengthening Via High-Intensity Plasma-Arc Heating SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID DYNAMIC FATIGUE; FLOAT GLASS; COATINGS AB A high-intensity plasma-arc lamp was used to irradiate the surface of soda-lime silicate glass tiles to determine whether an increase in strength could be achieved. The lamp has a maximum power density of 3500 W/cm2, a processing area of 2 cm x 10 cm, a broad-spectrum energy distribution between 0.2 and 1.4 mu m, and was controlled to unidirectionally sweep across 50 mm2 tiles at a constant speed of 8 mm/s. Ring-on-ring (RoR) equibiaxial flexure and four-point unidirectional flexure testings of entire tiles were used to measure and compare uncensored and unimodal Weibull failure stress distributions of treated and untreated glass. Even under nonoptimized processing conditions, the RoR Weibull characteristic failure stress increased by approximately 25% and the four-point-bend Weibull characteristic failure stress increased by approximately 65%. Additionally, the failure stresses of the weakest samples of the heat-treated glass were significantly higher than those of the untreated glass. Strengthening was due to a fire-polishing-like mechanism. The arc-lamp heat treatment caused the location of the strength-limiting flaws in the four-point-bend tiles to change; namely, failure initiation occurred on the gauge section surface for the treated glass, whereas it occurred at a gauge section edge for the untreated glass. Arc-lamp heat treatment is attractive not only because it provides strengthening, but because it can (noncontact) process large amounts of glass quickly and inexpensively, and is a process that either a glass manufacturer or an end-user can readily use. C1 [Wereszczak, Andrew A.] Oak Ridge Natl Lab, Ceram Sci & Technol Grp, Oak Ridge, TN 37831 USA. [Harper, David C.; Duty, Chad E.] Oak Ridge Natl Lab, Mat Proc Grp, Oak Ridge, TN 37831 USA. [Patel, Parimal] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Wereszczak, AA (reprint author), Oak Ridge Natl Lab, Ceram Sci & Technol Grp, Oak Ridge, TN 37831 USA. EM wereszczakaa@ornl.gov RI Wereszczak, Andrew/I-7310-2016 OI Wereszczak, Andrew/0000-0002-8344-092X FU U.S. Army Tank-Automotive Research, Development and Engineering Center [DE-AC-00OR22725]; U.S. Department of Energy [DE-AC05-00OR22725] FX Research performed under Work For Others funded by U.S. Army Tank-Automotive Research, Development and Engineering Center, under contract DE-AC-00OR22725 with UT-Battelle, LLC.; This submission was produced by a contractor of the U.S. Government under contract DE-AC05-00OR22725 with the U.S. Department of Energy. The U. S. Government retains, and the publisher, by accepting this submission for publication, acknowledges that the U.S. Government retains, a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this submission, or allow others to do so, for U. S. Government purposes. NR 22 TC 1 Z9 1 U1 1 U2 7 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD MAY PY 2010 VL 93 IS 5 BP 1256 EP 1259 DI 10.1111/j.1551-2916.2009.03553.x PG 4 WC Materials Science, Ceramics SC Materials Science GA 588PC UT WOS:000277083500013 ER PT J AU Champion, HR Holcomb, JB Lawnick, MM Kelliher, T Spott, MA Galarneau, MR Jenkins, DH West, SA Dye, J Wade, CE Eastridge, BJ Blackbourne, LH Shair, EK AF Champion, Howard R. Holcomb, John B. Lawnick, Mary M. Kelliher, Timothy Spott, Mary Ann Galarneau, Michael R. Jenkins, Donald H. West, Susan A. Dye, Judy Wade, Charles E. Eastridge, Brian J. Blackbourne, Lorne H. Shair, Ellen Kalin TI Improved Characterization of Combat Injury SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Abbreviated Injury Scale (AIS); Maximum AIS (MAIS); AIS 2005-Military; Maximum AIS Military (MAIS-Military); Combat registry; Combat injury; Combat casualty; Injury; Database; Wounds ID OPERATION-ENDURING-FREEDOM; SYSTEM; THEATER; CARE AB Background: Combat injury patterns differ from civilian trauma in that the former are largely explosion-related, comprising multiple mechanistic and fragment injuries and high-kinetic-energy bullets. Further, unlike civilians, U. S. armed forces combatants are usually heavily protected with helmets and Kevlar body armor with ceramic plate inserts. Searchable databases providing actionable, statistically valid knowledge of body surface entry wounds and resulting organ injury severity are essential to understanding combat trauma. Methods: Two tools were developed to address these unique aspects of combat injury: ( 1) the Surface Wound Mapping (SWM) database and Surface Wound Analysis Tool (SWAT) software that were developed to generate 3D density maps of point-of-surface wound entry and resultant anatomic injury severity; and (2) the Abbreviated Injury Scale (AIS) 2005-Military that was developed by a panel of military trauma surgeons to account for multiple injury etiology from explosions and other high-kinetic-energy weapons. Combined data from the Joint Theater Trauma Registry, Navy/Marine Combat Trauma Registry, and the Armed Forces Medical Examiner System Mortality Trauma Registry were coded in AIS 2005-Military, entered into the SWM database, and analyzed for entrance site and wounding path. Results: When data on 1,151 patients, who had a total of 3,500 surface wounds and 12,889 injuries, were entered into SWM, surface wounds averaged 3.0 per casualty and injuries averaged 11.2 per casualty. Of the 3,500 surface wounds, 2,496 (71%) were entrance wounds with 6,631 (51%) associated internal injuries, with 2.2 entrance wounds and 5.8 associated injuries per casualty (some details cannot be given because of operational security). Crude deaths rates were calculated using Maximum AIS-Military. Conclusion: These new tools have been successfully implemented to describe combat injury, mortality, and distribution of wounds and associated injuries. AIS 2005-Military is a more precise assignment of severity to military injuries. SWM has brought data from all three combat registries together into one analyzable database. SWM and SWAT allow visualization of wounds and associated injuries by region on a 3D model of the body. C1 [Champion, Howard R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA. [Lawnick, Mary M.; Kelliher, Timothy; Shair, Ellen Kalin] SimQuest LLC, Silver Spring, MD USA. [Spott, Mary Ann; West, Susan A.; Eastridge, Brian J.; Blackbourne, Lorne H.] USA, Inst Surg Res, Houston, TX USA. [Galarneau, Michael R.; Dye, Judy] USN, Hlth Res Ctr, San Diego, CA 92152 USA. [Jenkins, Donald H.] Mayo Clin, Rochester, MN USA. [Wade, Charles E.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Champion, HR (reprint author), 954 Melvin Rd, Annapolis, MD 21403 USA. EM hrchampion@aol.com FU US Army [W81XWH-04-0020, DAMD-01-P-0485, W81XWH-04-C-0134, W81XWH-06-C-0365, N41756-06-C-5518, W81XWH-05-2-0057] FX Supported by the US Army under Contract Nos. W81XWH-04-0020, DAMD-01-P-0485, W81XWH-04-C-0134, W81XWH-06-C-0365, N41756-06-C-5518, and W81XWH-05-2-0057. NR 23 TC 55 Z9 56 U1 0 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2010 VL 68 IS 5 BP 1139 EP 1150 DI 10.1097/TA.0b013e3181d86a0d PG 12 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 595MQ UT WOS:000277615200020 PM 20453770 ER PT J AU Batchinsky, AI Skinner, JE Necsoiu, C Jordan, BS Weiss, D Cancio, LC AF Batchinsky, Andriy I. Skinner, James E. Necsoiu, Corina Jordan, Bryan S. Weiss, Daniel Cancio, Leopoldo C. TI New Measures of Heart-Rate Complexity: Effect of Chest Trauma and Hemorrhage SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Pulmonary contusion; Hemorrhagic shock; Electrocardiography; Entropy; Complexity; Heart rate variability; Fractals; Nonlinear dynamics; Spectrum analysis ID 110 MM HG; CARDIOVASCULAR REGULATION; REDEFINING HYPOTENSION; CORRELATION DIMENSION; NONLINEAR DYNAMICS; RATE-VARIABILITY; INTERVALS; SYSTEMS; DISTRIBUTIONS; RESPIRATION AB Background: Traditional vital signs such as heart rate, blood pressure, and oxygen saturation are not ideal for timely and accurate assessment of physiologic status after trauma (TR) and hemorrhagic shock (HS). Analysis of the complex beat-to-beat variability present in the heart-rate time series has been proposed as a "new vital sign" in this setting. We determined the effect of chest TR and HS on heart-rate complexity (HRC) in a porcine model. Methods: Anesthetized swine in group II (n = 20) underwent blunt right chest TR with a modified captive-bolt stunner; then, 10 minutes later, hemorrhage of 12 mL/kg over 10 minutes, followed by resuscitation with lactated Ringer's solution, and reinfusion of blood. Group I (n = 15) served as time controls. Two hundred beat sections of EKG waveforms were analyzed at 7 time points: at baseline, after TR, immediately after hemorrhage (HS), and 1 hour, 2 hours, 4 hours, and 5 hours after HS. Several computationally different measures of HRC were calculated, including sample entropy, similarity of distribution, and point correlation dimension. Results: HRC was decreased after TR, HS, and at 1 hour, manifested by decreased sample entropy and point correlation dimension and increased similarity of distribution. These HRC measures were all restored by resuscitation. Conclusions: Several independent measures demonstrated decreased HRC after combined TR/HS and restored HRC with resuscitation. Complexity analysis may be useful for diagnosis of TR/HS and for monitoring resuscitation. C1 [Batchinsky, Andriy I.; Necsoiu, Corina; Jordan, Bryan S.; Cancio, Leopoldo C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Skinner, James E.; Weiss, Daniel] Vicor Technol Inc, Bangor, PA USA. RP Batchinsky, AI (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM andriy.batchinsky@amedd.army.mil RI Necsoiu, Corina/A-6255-2013 FU U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD FX Supported by the Combat Casualty Care research program, U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD. NR 44 TC 20 Z9 21 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0022-5282 EI 1529-8809 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2010 VL 68 IS 5 BP 1178 EP 1185 DI 10.1097/TA.0b013e3181bb98a6 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 595MQ UT WOS:000277615200024 PM 20173662 ER PT J AU Pina, JS Moghadam, S Cushner, HM Beilman, GJ McAlister, VC AF Pina, Joseph S. Moghadam, Soraya Cushner, Howard M. Beilman, Greg J. McAlister, Vivian C. TI In-Theater Peritoneal Dialysis for Combat-Related Renal Failure SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Combat-related renal failure; Renal replacement therapy; Peritoneal dialysis AB Background: Complications of renal failure may prevent timely evacuation of injured soldiers. Conventional renal replacement therapy is not available in forward surgical units. Methods: Records of in-theater improvised peritoneal dialysis (IPD) in level III hospitals or forward surgical units in Iraq or Afghanistan were reviewed to determine the following: cause of renal failure and associated injuries; type of dialysate, peritoneal access, and exchange technique; and patient outcome. These data were used to propose method for IPD using commonly available materials. Results: IPD is described in four patients. Abdominal or chest drains were used with either improvised dextrose-electrolyte solution or commercial dialysate. Exchanges were successful, despite fresh surgical wounds including full laparotomy, removed excess fluid and restored acid and electrolyte balance, but did not correct azotemia. Open abdominal packing prevented continuation of IPD after 48 hours. Two patients fully recovered, one died, and one patient with a poor prognosis was lost to follow-up. Conclusion: IPD can be delivered effectively using readily available materials in forward surgical units and level III combat support hospitals. C1 [Pina, Joseph S.] US Army Pacific, Tacoma, WA USA. [Moghadam, Soraya; McAlister, Vivian C.] Canadian Forces Med Serv, Tacoma, WA USA. [Cushner, Howard M.] Madigan Army Med Ctr, Serv Nephrol, Tacoma, WA 98431 USA. [Beilman, Greg J.] Univ Minnesota, Sch Med, Dept Surg, Div Surg Crit Care, Minneapolis, MN 55455 USA. RP McAlister, VC (reprint author), C4 212 Univ Hosp, London, ON N6A 5A5, Canada. EM vmcalist@uwo.ca RI McAlister, Vivian/B-9881-2008; OI McAlister, Vivian/0000-0002-2479-6862; Beilman, Gregory/0000-0001-5036-3027 NR 8 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2010 VL 68 IS 5 BP 1253 EP 1256 DI 10.1097/TA.0b013e3181d99089 PG 4 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 595MQ UT WOS:000277615200035 PM 20453775 ER PT J AU Spinella, PC Holcomb, JB AF Spinella, Philip C. Holcomb, John B. TI Damage Control Resuscitation Using Warm Fresh Whole Blood: A Paramount Role for Leukocytes and Derived Microparticles in the Prevention of Coagulation Abnormalities? Reply SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Letter C1 [Spinella, Philip C.] Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT 06106 USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Dept Surg, Hartford, CT USA. [Spinella, Philip C.] Univ Connecticut, Storrs, CT 06269 USA. [Spinella, Philip C.] US Army ISR, Blood Res Program, San Antonio, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr San Antonio, Div Acute Care Surg, Houston, TX USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr San Antonio, Ctr Translat Injury Res, Houston, TX USA. RP Spinella, PC (reprint author), Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT 06106 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 2010 VL 68 IS 5 BP 1267 EP 1267 DI 10.1097/TA.0b013e3181d53de2 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 595MQ UT WOS:000277615200042 ER PT J AU Goodyer, LI Croft, AM Frances, SP Hill, N Moore, SJ Onyango, SP Debboun, M AF Goodyer, Larry I. Croft, Ashley M. Frances, Steve P. Hill, Nigel Moore, Sarah J. Onyango, Sangoro P. Debboun, Mustapha TI Expert Review of the Evidence Base for Arthropod Bite Avoidance SO JOURNAL OF TRAVEL MEDICINE LA English DT Review ID LONE STAR TICK; PERMETHRIN-TREATED UNIFORMS; RESISTANT ANOPHELES-GAMBIAE; EUCALYPTUS-BASED REPELLENT; AMBLYOMMA-HEBRAEUM ACARI; AEDES-AEGYPTI L; FIELD-EVALUATION; INSECT REPELLENTS; PERSONAL PROTECTION; MOSQUITO REPELLENT C1 [Goodyer, Larry I.] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England. [Frances, Steve P.] Australian Army Malaria Inst, Brisbane, Qld, Australia. [Croft, Ashley M.] Dept Gen Surg, London, England. [Hill, Nigel; Moore, Sarah J.; Onyango, Sangoro P.] London Sch Hyg & Trop Med, London WC1, England. [Moore, Sarah J.; Onyango, Sangoro P.] Ifakara Hlth Inst, Morogoro, Tanzania. [Debboun, Mustapha] USA, Med Dept Ctr & Sch, Ctr Hlth Educ & Training, Houston, TX USA. RP Goodyer, LI (reprint author), De Montfort Univ, Leicester Sch Pharm, Hawthorn Bldg,Gateway, Leicester LE1 9BH, Leics, England. EM LGoodyer@dmu.ac.uk NR 145 TC 38 Z9 42 U1 0 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD MAY-JUN PY 2010 VL 17 IS 3 BP 182 EP 192 DI 10.1111/j.1708-8305.2010.00402.x PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 586TB UT WOS:000276935000008 PM 20536888 ER PT J AU Mazumder, SA Pandey, S Brewer, SC Baselski, VS Weina, PJ Land, MA Fleckenstein, JM AF Mazumder, Shirin A. Pandey, Soumya Brewer, Susan C. Baselski, Vickie S. Weina, Peter J. Land, Mack A. Fleckenstein, James M. TI Lingual Leishmaniasis Complicating Visceral Disease SO JOURNAL OF TRAVEL MEDICINE LA English DT Article ID OPERATION-DESERT-STORM; INFECTION; TONGUE; TROPICA AB Leishmania species are obligate intracellular parasites transmitted by various types of female sand flies. The clinical syndrome that results depends on a number of factors including the Leishmania species and immune response of the host. Here, we report successful treatment of lingual leishmaniasis complicating visceral disease in an immunocompetent patient. C1 [Mazumder, Shirin A.; Brewer, Susan C.; Land, Mack A.; Fleckenstein, James M.] Univ Tennessee, Hlth Sci Ctr, Div Infect Dis, Dept Med, Memphis, TN USA. [Pandey, Soumya; Baselski, Vickie S.] Univ Tennessee, Hlth Sci Ctr, Dept Pathol, Memphis, TN USA. [Weina, Peter J.] Vet Affairs Med Ctr, Div Infect Dis, Memphis, TN USA. [Fleckenstein, James M.] Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20307 USA. RP Mazumder, SA (reprint author), 1211 Union Ave,Suite 340, Memphis, TN 38104 USA. EM smazumde@uthsc.edu OI Fleckenstein, James/0000-0002-1148-697X NR 12 TC 2 Z9 2 U1 0 U2 1 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1195-1982 J9 J TRAVEL MED JI J. Travel Med. PD MAY-JUN PY 2010 VL 17 IS 3 BP 212 EP U72 DI 10.1111/j.1708-8305.2010.00403.x PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 586TB UT WOS:000276935000016 PM 20536896 ER PT J AU Goei, AD Findeiss, LK Slim, AM AF Goei, Anthony D. Findeiss, Laura K. Slim, Ahmad M. TI Medical Management in Peripheral Arterial Disease: A Systematic Approach to Medical Therapy SO JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY LA English DT Article ID LEFT-VENTRICULAR DYSFUNCTION; CONVERTING-ENZYME-INHIBITOR; HIGH-RISK PATIENTS; MYOCARDIAL-INFARCTION; METAANALYSIS; PREVENTION; MORBIDITY; MORTALITY; EVENTS; TRIALS AB The American College of Cardiology/American Heart Association 2005 Guidelines for the Management of Patients with Peripheral Arterial Disease (PAD) emphasize the importance of cardiovascular risk reduction in all patients with PAD as a result of the high likelihood of coexisting atherosclerotic disease of the peripheral, coronary, and cerebral circulations. The guidelines outline the clear and definite role for antiplatelet, lipid-lowering, and antihypertensive drugs as well as adequate diabetic control. All practicing interventional radiologists should be familiar with these practical and useful guidelines, as well as the rationale for use of each of these medications. C1 [Goei, Anthony D.] Brooke Army Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, Ft Sam Houston, TX 78234 USA. [Slim, Ahmad M.] Brooke Army Med Ctr, Dept Cardiol, Ft Sam Houston, TX 78234 USA. [Findeiss, Laura K.] Univ Calif Irvine, Med Ctr, Dept Radiol Sci, Orange, CA USA. RP Goei, AD (reprint author), Brooke Army Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM anthony.goei@amedd.army.mil NR 12 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1051-0443 J9 J VASC INTERV RADIOL JI J. Vasc. Interv. Radiol. PD MAY PY 2010 VL 21 IS 5 BP 603 EP 605 DI 10.1016/j.jvir.2010.01.009 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging; Peripheral Vascular Disease SC Radiology, Nuclear Medicine & Medical Imaging; Cardiovascular System & Cardiology GA 596DZ UT WOS:000277666000001 PM 20227298 ER PT J AU Nadal, NC Zapata, RE Pagan, I Lopez, R Agudelo, J AF Nadal, Norberto C. Zapata, Raul E. Pagan, Ismael Lopez, Ricardo Agudelo, Jairo TI Building Damage due to Riverine and Coastal Floods SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article DE Building damage; Riverine flood; Storm surge; Tsunami; Local scour; Coastal flood ID BRIDGE PIERS; LOCAL SCOUR; TIME-SCALE AB Floods in both riverine and coastal zones can cause significant damage to infrastructure, including possible structural failure of buildings. Methodologies commonly used to estimate flood damage to buildings are typically based on aftermath surveys and statistical analyses of insurance claims data. These methodologies rarely account for flooding hydrodynamics, and thus do not differentiate between the damage caused by floodwater contact and those caused by floodwater velocity. A new stochastic methodology has been developed to estimate the direct impact of flood actions on buildings and to determine the expected damage. Building vulnerability is modeled based on analytical representations of the failure mechanisms of individual building components. The flood actions generated during different flooding events are assessed and compared to the resistance of each building component. The assessed flood actions include: hydrostatic and hydrodynamic forces, waves, turbulent bores, debris impacts, and time-dependent local soil scour. Monte Carlo simulation was used to synthetically expand the available building data, to perform load-resistance analysis, and to account for the uncertainty of input parameters. The primary result from this study is the expected flood damage to individual buildings, and it is expressed as a three-dimensional functions dependent on both floodwater depth and floodwater velocity. The results show how floodwater velocity can increase the magnitude of the flood damage outcome compared to those that solely consider water depth. This demonstrates the real need for considering floodwater hydrodynamics in the vulnerability assessment of buildings located in flood prone areas. Although the present study focuses on the vulnerability of reinforced concrete frame buildings with infill concrete-block walls, the methodology can also be applied to other types of structures. This methodology could serve as a decision-making tool to assist engineers and emergency management agencies to identify zones of high risk, and to implement the necessary preventive measures and mitigation strategies to minimize the adverse impact of potential flooding events. C1 [Nadal, Norberto C.] USACE ERDC Coastal & Hydraul Lab, Vicksburg, MS 39180 USA. [Zapata, Raul E.; Pagan, Ismael; Lopez, Ricardo; Agudelo, Jairo] Univ Puerto Rico, Dept Civil Engn & Surveying, Mayaguez, PR 00681 USA. RP Nadal, NC (reprint author), USACE ERDC Coastal & Hydraul Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Norberto.C.Nadal@usace.army.mil RI Rinaldi2, Carlos/D-4479-2011 FU Insurance Commissioner of Puerto Rico; NSF [HRD98117642] FX This study was sponsored by the Insurance Commissioner of Puerto Rico under contract with the Department of Civil Engineering and Surveying of the University of Puerto Rico at Mayaguez. This research work was the object of the main writer's Ph. D. thesis who was awarded the Alliance for Graduate Education and the Professoriate Fellowship (NSF Grant. No. HRD98117642). Beneficial review was provided by Dr. Zeki Demirbilek, U. S. Army Engineer Research and Development Center. NR 30 TC 19 Z9 20 U1 3 U2 33 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD MAY-JUN PY 2010 VL 136 IS 3 BP 327 EP 336 DI 10.1061/(ASCE)WR.1943-5452.0000036 PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 583QJ UT WOS:000276693200005 ER PT J AU Reichold, L Zechman, EM Brill, ED Holmes, H AF Reichold, Laurel Zechman, Emily M. Brill, E. Downey Holmes, Hillary TI Simulation-Optimization Framework to Support Sustainable Watershed Development by Mimicking the Predevelopment Flow Regime SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article DE Simulation optimization; Watershed management; Urbanization; Modeling to generate alternatives; Genetic algorithm ID GENERATE ALTERNATIVES; HYDROLOGIC ALTERATION; COMMUNITY STRUCTURE; OPTIMAL LOCATION; FRESH-WATER; MANAGEMENT; RIVERS; SYSTEMS; NEED; ENGLAND AB The modification of land and water resources for human use alters the natural hydrologic flow regime of a downstream receiving body of water. The natural flow regime is essential for sustaining biotic structure and equilibrium within the ecosystem. Best management practices mitigate the increased storm water runoff due to increased imperviousness and are typically designed and located within a watershed to match peak and minimum flows for a small set of targeted design storms. Ecosystems are, however, affected by all the characteristics of a long-term flow regime, including the magnitude, duration, frequency, and timing of flows. A more environmentally sustainable approach for watershed development is presented based on the minimization of differences in the characteristics of the flow regime between predevelopment and postdevelopment conditions. The indicator of hydrologic alteration (IHA) is a set of 33 hydrologic indices that characterize a flow regime and, coupled with the range of variability approach (RVA), can be used to evaluate a development strategy for its alteration of the long-term hydrologic flow regime. This paper presents a methodology to identify watershed management strategies that will have a minimal impact on the flow regime and downstream ecosystems. This methodology utilizes a metric that evaluates development strategies based on an IHA/RVA analysis implemented within a simulation-optimization framework. Continuous simulation of urban runoff for different land use strategies is enabled through the use of the storm water management model, and the resulting long-term hydrograph is analyzed using IHA/RVA. Development is allocated within subcatchments to maintain a predefined minimum level of total development while minimizing the hydrologic alteration. A hybrid optimization approach based on genetic algorithm and Nelder-Meade approaches is used to identify optimal land use allocation. Further analysis is conducted to identify alternative development patterns that allocate impervious development maximally differently among subcatchments while achieving similarly low alteration in the hydrologic flow regime. C1 [Zechman, Emily M.; Holmes, Hillary] Texas A&M Univ, Dept Civil Engn, College Stn, TX 77843 USA. [Reichold, Laurel] USA, Corps Engineers, Jacksonville, FL USA. [Brill, E. Downey] N Carolina State Univ, Dept Civil Engn, Raleigh, NC 27695 USA. RP Zechman, EM (reprint author), Texas A&M Univ, Dept Civil Engn, 3136 TAMU, College Stn, TX 77843 USA. EM hillaryholmes@neo.tamu.edu; ezechman@tamu.edu; brill@ncsu.edu; hillaryholmes@neo.tamu.edu NR 61 TC 19 Z9 20 U1 3 U2 26 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD MAY-JUN PY 2010 VL 136 IS 3 BP 366 EP 375 DI 10.1061/(ASCE)WR.1943-5452.0000040 PG 10 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA 583QJ UT WOS:000276693200009 ER PT J AU Enewold, L Brinton, LA McGlynn, KA Zahm, SH Potter, JF Zhu, KM AF Enewold, Lindsey Brinton, Louise A. McGlynn, Katherine A. Zahm, Shelia H. Potter, John F. Zhu, Kangmin TI Oral Contraceptive Use Among Women in the Military and the General US Population SO JOURNAL OF WOMENS HEALTH LA English DT Article ID OVARIAN-CANCER RISK; BREAST-CANCER; COLLABORATIVE REANALYSIS; ENDOMETRIAL CANCER; METAANALYSIS; COHORT; POTENCY AB Objective: To compare oral contraceptive (OC) use during a 12-month period among women aged 18-39 years in the U. S. military and the general U. S. population using data from the Military Health System Management Analysis and Reporting Tool (M2) and the National Health and Nutrition Examination Survey (NHANES), respectively. Methods: OC use was age adjusted to the 2000 U. S. Census population. Comparisons between the military (n = 83,181) and the general population (unweighted n = 360), as well as between the military branches, were conducted overall and stratified by age, race/ethnicity, and marital status. Results: OC use was higher in the military (34%) than in the general population (29%, p<0.05). This difference increased with age and was most pronounced among Hispanics (military, 32.2%; general population, 19.8%). Within the military, OC use was highest in the Air Force (39%) and lowest in the Army (30%, p<0.05). Conclusions: These findings suggest that OC use differs between the military and the general population and within the military by service branch. Further studies that assess whether OC use is related to variations in health outcomes between these two populations and within the military are warranted. C1 [Enewold, Lindsey] US Mil Canc Inst, Armed Forces Inst Pathol, Walter Reed Army Med Ctr, Washington, DC 20306 USA. [Brinton, Louise A.; McGlynn, Katherine A.; Zahm, Shelia H.] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA. [Potter, John F.; Zhu, Kangmin] Uniformed Serv Univ Hlth Sci, Bethesda, MD USA. RP Enewold, L (reprint author), US Mil Canc Inst, Armed Forces Inst Pathol, Walter Reed Army Med Ctr, Bldg 54,Room N1512,6825 16th St NW, Washington, DC 20306 USA. EM lindsey.enewold@us.army.mil RI Zahm, Shelia/B-5025-2015; Brinton, Louise/G-7486-2015 OI Brinton, Louise/0000-0003-3853-8562 FU DCEG; NCI; NIH; Department of Health and Human Services; United States Military Cancer Institute via the Uniformed Services University of the Health Sciences FX This study was partly supported by the Intramural Research Program of the DCEG, NCI, NIH, Department of Health and Human Services, and by the United States Military Cancer Institute via the Uniformed Services University of the Health Sciences under the auspices of the Henry M. Jackson Foundation for the Advancement of Military Medicine. NR 42 TC 12 Z9 12 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-9996 J9 J WOMENS HEALTH JI J. Womens Health PD MAY PY 2010 VL 19 IS 5 BP 839 EP 845 DI 10.1089/jwh.2009.1706 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Obstetrics & Gynecology; Women's Studies SC Public, Environmental & Occupational Health; General & Internal Medicine; Obstetrics & Gynecology; Women's Studies GA 595HW UT WOS:000277602300003 PM 20350205 ER PT J AU Geisbert, TW Lee, ACH Robbins, M Geisbert, JB Honko, AN Sood, V Johnson, JC de Jong, S Tavakoli, I Judge, A Hensley, LE MacLachlan, I AF Geisbert, Thomas W. Lee, Amy C. H. Robbins, Marjorie Geisbert, Joan B. Honko, Anna N. Sood, Vandana Johnson, Joshua C. de Jong, Susan Tavakoli, Iran Judge, Adam Hensley, Lisa E. MacLachlan, Ian TI Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study SO LANCET LA English DT Article ID SYNTHETIC SIRNA; GUINEA-PIGS; INFECTION; STIMULATION; MODEL; MICE AB Background We previously showed that small interfering RNAs (siRNAs) targeting the Zaire Ebola virus (ZEBOV) RNA polymerase L protein formulated in stable nucleic acid-lipid particles (SNALPs) completely protected guineapigs when administered shortly after a lethal ZEBOV challenge. Although rodent models of ZEBOV infection are useful for screening prospective countermeasures, they are frequently not useful for prediction of efficacy in the more stringent non-human primate models. We therefore assessed the efficacy of modified non-immunostimulatory siRNAs in a uniformly lethal non-human primate model of ZEBOV haemorrhagic fever. Methods A combination of modified siRNAs targeting the ZEBOV L polymerase (EK-1 mod), viral protein (VP) 24 (VP24-1160 mod), and VP35 (VP35-855 mod) were formulated in SNALPs. A group of macaques (n=3) was given these pooled anti-ZEBOV siRNAs (2 mg/kg per dose, bolus intravenous infusion) after 30 min, and on days 1, 3, and 5 after challenge with ZEBOV. A second group of macaques (n=4) was given the pooled anti-ZEBOV siRNAs after 30 min, and on days 1, 2, 3, 4, 5, and 6 after challenge with ZEBOV. Findings Two (66%) of three rhesus monkeys given four postexposure treatments of the pooled anti-ZEBOV siRNAs were protected from lethal ZEBOV infection, whereas all macaques given seven postexposure treatments were protected. The treatment regimen in the second study was well tolerated with minor changes in liver enzymes that might have been related to viral infection. Interpretation This complete postexposure protection against ZEBOV in non-human primates provides a model for the treatment of ZEBOV-induced haemorrhagic fever. These data show the potential of RNA interference as an effective postexposure treatment strategy for people infected with Ebola virus, and suggest that this strategy might also be useful for treatment of other emerging viral infections. C1 [Geisbert, Thomas W.; Geisbert, Joan B.] Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Honko, Anna N.; Johnson, Joshua C.; Hensley, Lisa E.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. [Lee, Amy C. H.; Robbins, Marjorie; Sood, Vandana; de Jong, Susan; Tavakoli, Iran; Judge, Adam; MacLachlan, Ian] Tekmira Pharmaceut, Burnaby, BC, Canada. RP Geisbert, TW (reprint author), Boston Univ, Sch Med, Natl Emerging Infect Dis Labs Inst, 620 Albany St,Room 401B, Boston, MA 02118 USA. EM geisbert@bu.edu OI Honko, Anna/0000-0001-9165-148X FU Defense Threat Reduction Agency [04-4-7J-012] FX Work on filoviruses at US Army Medical Research Institute of Infectious Diseases was funded by the Defense Threat Reduction Agency (project number 04-4-7J-012). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by Boston University or the US Army. NR 30 TC 239 Z9 256 U1 6 U2 68 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD MAY-JUN PY 2010 VL 375 IS 9729 BP 1896 EP 1905 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA 609BC UT WOS:000278628800031 PM 20511019 ER PT J AU Zhang, MY Borges, AR Ptak, RG Wang, YP Dimitrov, AS Alam, SM Wieczorek, L Bouma, P Fouts, T Jiang, SB Polonis, VR Haynes, BF Quinnan, GV Montefiori, DC Dimitrov, DS AF Zhang, Mei-Yun Borges, Andrew Rosa Ptak, Roger G. Wang, Yanping Dimitrov, Antony S. Alam, S. Munir Wieczorek, Lindsay Bouma, Peter Fouts, Timothy Jiang, Shibo Polonis, Victoria R. Haynes, Barton F. Quinnan, Gerald V. Montefiori, David C. Dimitrov, Dimiter S. TI Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1 SO MABS LA English DT Article DE HIV; AIDS; antibodies; scFv; microbicides; therapeutics; vaccines ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODY; SEXUALLY-TRANSMITTED INFECTIONS; CORECEPTOR BINDING-SITE; ANTIRETROVIRAL THERAPY; ENVELOPE GLYCOPROTEIN; PASSIVE-IMMUNIZATION; GP120; MICROBICIDES; PREVENTION AB Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad neutralizing activity against HIV-1, but there has not been much success in using them as potential therapeutics. We have previously hypothesized and demonstrated that small engineered antibodies can target highly conserved epitopes that are not accessible by full-size antibodies. However, their potency has not been comparatively evaluated with known HIV-1-neutralizing hmAbs against large panels of primary isolates. We report here the inhibitory activity of an engineered single chain antibody fragment (scFv), m9, against several panels of primary HIV-1 isolates from group M (clades A-G) using cell-free and cell-associated virus in cell line-based assays. M9 was much more potent than scFv 17b, and more potent than or comparable to the best-characterized broadly neutralizing hmAbs lgG(1) b12, 2G12, 2F5 and 4E10. It also inhibited cell-to-cell transmission of HIV-1 with higher potency than enfuvirtide (T-20, Fuzeon). M9 competed with a sulfated CCR5 N-terminal peptide for binding to gp120-CD4 complex, suggesting an overlapping epitope with the coreceptor binding site. M9 did not react with phosphatidylserine (PS) and cardiolipin (CL), nor did it react with a panel of autoantigens in an antinuclear autoantibody (ANA) assay. We further found that escape mutants resistant to m9 did not emerge in an immune selection assay. These results suggest that m9 is a novel anti-HIV-1 candidate with potential therapeutic or prophylactic properties, and its epitope is a new target for drug or vaccine development. C1 [Zhang, Mei-Yun] Univ Hong Kong, Li Ka Shing Fac Med, AIDS Inst, Pokfulam, Hong Kong, Peoples R China. [Zhang, Mei-Yun; Wang, Yanping; Dimitrov, Dimiter S.] NCI Frederick, CCRNP, CCR, NIH, Frederick, MD USA. [Borges, Andrew Rosa; Wieczorek, Lindsay] Henry M Jackson Fdn, Dept Vaccine Res, US Mil HIV Res Program, Rockville, MD USA. [Dimitrov, Antony S.; Fouts, Timothy] Profectus BioSci Inc, Baltimore, MD USA. [Wang, Yanping] SAIC Frederick Inc, NCI Frederick, Basic Res Program, Frederick, MD USA. [Ptak, Roger G.] So Res Inst, Frederick, MD USA. [Bouma, Peter; Quinnan, Gerald V.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Alam, S. Munir; Haynes, Barton F.] Duke Univ, Med Ctr, Duke Human Vaccine Inst, Durham, NC 27710 USA. [Jiang, Shibo] New York Blood Ctr, Lindsley F Kimball Res Inst, Lab Viral Immunol, New York, NY 10021 USA. [Polonis, Victoria R.] Walter Reed Army Inst Res, Div Retrovirol, US Mil HIV Res Program, Rockville, MD USA. RP Zhang, MY (reprint author), Univ Hong Kong, Li Ka Shing Fac Med, AIDS Inst, Pokfulam, Hong Kong, Peoples R China. EM zhangmy@hku.hk RI Zhang, Mei-Yun/E-9908-2010; Jiang, Shibo/L-4500-2014; OI Fouts, Timothy/0000-0002-2429-2859 FU The University of Hong Kong; NIH; NIH, National Cancer Institute, Center for Cancer Research; Gates Foundation; NIH, National Cancer Institute [NO1-CO-12400]; Southern Research Institute FX We thank Drs. Robert Blumenthal, Peter Kwong and Michael Fung for their helpful discussions. We also thank Monogram Biosciences for performing U87 cell line-based assays, Clay Osterling for performing the CCR5-dependent cell-to-cell transmission assays, and Ms. Jenny Ng for help with preparation of the manuscript. This research was supported by the internal funds from The University of Hong Kong, by the NIH Intramural AIDS Targeted Antiviral Program (IATAP), the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, and the Gates Foundation to DSD, by Federal funds from the NIH, National Cancer Institute, under Contract No. NO1-CO-12400, and by internal funds from Southern Research Institute. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does the mention of trade names, commercial products or organizations imply endorsement by the US Government. NR 47 TC 10 Z9 10 U1 1 U2 3 PU LANDES BIOSCIENCE PI AUSTIN PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA SN 1942-0862 J9 MABS-AUSTIN JI mAbs PD MAY-JUN PY 2010 VL 2 IS 3 BP 266 EP 274 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 644OL UT WOS:000281388200006 PM 20305395 ER PT J AU Nierenberg, NE Thompson, GR Lewis, JS Hogan, BK Patterson, TF AF Nierenberg, Natalie E. Thompson, George R., III Lewis, James S., II Hogan, Brian K. Patterson, Thomas F. TI Voriconazole use and pharmacokinetics in combination with interferon-gamma for refractory cryptococcal meningitis in a patient receiving low-dose ritonavir SO MEDICAL MYCOLOGY LA English DT Article DE cryptococcus; voriconazole; salvage; therapeutic drug monitoring ID FUNGAL-INFECTIONS; ANTIFUNGAL CHEMOTHERAPY; ADVERSE EVENTS; SAFETY; POSACONAZOLE; NEOFORMANS; EFFICACY AB We present a case of relapsing cryptococcal meningitis unresponsive to standard therapy. Voriconazole induction, including the utilization of voriconazole therapeutic drug monitoring in both serum and CSF, with transition to voriconazole plus interferon-gamma (IFN-gamma) was successfully used in a patient receiving antiretroviral therapy with abacavir/lamivudine and lopinavir/ritonavir. Initial voriconazole levels at standard doses of 4 mg/kg twice daily intravenously were low when co-administered with lopinavir/ritonavir but increased to recommended therapeutic levels with an increase of the voriconazole dose to 7 mg/kg twice daily. This case highlights the utility of voriconazole therapeutic drug monitoring when prescribed concurrently with a ritonavir boosted protease inhibitor and the potential role of combination therapy with IFN-gamma for refractory cryptococcal meningitis. C1 [Nierenberg, Natalie E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Internal Med, Div Gen Med, San Antonio, TX 78229 USA. [Thompson, George R., III; Lewis, James S., II; Patterson, Thomas F.] Univ Texas Hlth Sci Ctr San Antonio, Div Infect Dis, San Antonio, TX 78229 USA. [Lewis, James S., II] Univ Texas Hlth Sci Ctr San Antonio, Pharm Serv Univ Hlth Syst, San Antonio, TX 78229 USA. [Hogan, Brian K.] Brooke Army Med Ctr, San Antonio, TX USA. [Thompson, George R., III; Patterson, Thomas F.] S Texas Vet Hlth Care Syst, San Antonio, TX USA. RP Nierenberg, NE (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Internal Med, Div Gen Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA. EM nierenberg@uthscsa.edu FU Basilea; Merck; Pfizer; Schering-Plough FX Declaration of interest: G. R. T. has served as a consultant for Basilea. T. F. P. has received research support from Basilea, Merck, Pfizer, and Schering-Plough and has received honoraria or served as a consultant for Basilea, Merck, and Pfizer. All other authors have no potential conflicts to disclose. NR 19 TC 10 Z9 11 U1 0 U2 2 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1369-3786 J9 MED MYCOL JI Med. Mycol. PD MAY PY 2010 VL 48 IS 3 BP 532 EP 536 DI 10.3109/13693780903325282 PG 5 WC Infectious Diseases; Mycology; Veterinary Sciences SC Infectious Diseases; Mycology; Veterinary Sciences GA 579IV UT WOS:000276363900014 PM 19835489 ER PT J AU Scofield, DE DeGroot, DW Miller, JK Ely, MR Karl, JP Nindl, BC AF Scofield, Dennis E. DeGroot, Dave W. Miller, Jeremy K. Ely, Matthew R. Karl, J. Philip Nindl, Bradley C. TI IGF-I Concentrations Are Altered in Serum, But Not Transdermal Fluid During Underfeeding And Overfeeding SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Scofield, Dennis E.; DeGroot, Dave W.; Miller, Jeremy K.; Ely, Matthew R.; Karl, J. Philip; Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM dennis.scofield@amedd.army.mil RI SCOFIELD, DENNIS/F-3636-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 644 BP 18 EP 18 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300052 ER PT J AU Gregory, RW Still, TK Carow, SD Hitt, JK Brechue, WF AF Gregory, Robert W. Still, Tiernan K. Carow, Scott D. Hitt, Joseph K. Brechue, William F. TI Mechanics of the West Point Bionic Foot During Walking: A Case Study SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Gregory, Robert W.; Still, Tiernan K.; Carow, Scott D.; Hitt, Joseph K.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. EM robert.gregory@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 654 BP 21 EP 21 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300061 ER PT J AU Moore, JH Goffar, SL Teyhen, DS Pendergrass, TL Ficke, JR AF Moore, Josef H. Goffar, Steven L. Teyhen, Deydre S. Pendergrass, Timothy L. Ficke, James R. TI Sports Medicine on the Battlefield SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Moore, Josef H.; Goffar, Steven L.; Teyhen, Deydre S.] AMEDDC&S, Grad Sch, Ft Sam Houston, TX USA. [Pendergrass, Timothy L.] USASOC, Ft Bragg, NC USA. [Ficke, James R.] BAMC, Ft Sam Houston, TX USA. EM josef.moore@amedd.army.mil NR 0 TC 2 Z9 2 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 690 BP 33 EP 33 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300093 ER PT J AU Lunn, WR Colletto, MR Karfonta, KE Anderson, JM Pasiakos, SM Ferrando, AA Wolfe, RR Rodriguez, NR AF Lunn, William R. Colletto, Megan R. Karfonta, Kirstin E. Anderson, Jeffrey M. Pasiakos, Stefan M. Ferrando, Arny A. Wolfe, Robert R. Rodriguez, Nancy R. TI Chocolate Milk Consumption Following Endurance Exercise Affects Skeletal Muscle Protein Fractional Synthetic Rate and Intracellular Signaling SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Lunn, William R.; Colletto, Megan R.; Karfonta, Kirstin E.; Anderson, Jeffrey M.; Rodriguez, Nancy R.] Univ Connecticut, Storrs, CT USA. [Pasiakos, Stefan M.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Ferrando, Arny A.; Wolfe, Robert R.] Univ Arkansas Med Sci, Little Rock, AR 72205 USA. [Ferrando, Arny A.; Wolfe, Robert R.] Donald W Reynolds Inst Aging, Little Rock, AR USA. EM wlunn25@comcast.net NR 0 TC 0 Z9 0 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 794 BP 64 EP 64 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300186 ER PT J AU Moeckel-Cole, SA Moore, N Zambraski, E Gordish-Dressman, H Hoffman, E Devaney, J Clarkson, P AF Moeckel-Cole, Stephanie A. Moore, Nina Zambraski, Edward Gordish-Dressman, Heather Hoffman, Eric Devaney, Joe Clarkson, Priscilla TI Possession Of Slc30a8 TT Genotype Mitigates The Effects Of Eccentric Exercise In Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Moeckel-Cole, Stephanie A.; Moore, Nina; Clarkson, Priscilla] Univ Massachusetts, Amherst, MA 01003 USA. [Zambraski, Edward] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Gordish-Dressman, Heather; Hoffman, Eric; Devaney, Joe] Childrens Natl Med Ctr, Washington, DC 20010 USA. EM smcole@kin.umass.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 866 BP 87 EP 87 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300249 ER PT J AU Judge, L Bellar, D Kamimori, G AF Judge, Lawrence Bellar, David Kamimori, Gary TI The Effect Of Caffeine On Psycho-motor And Athletic Performance In The Shot Put Throw SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Judge, Lawrence] Ball State Univ, Muncie, IN 47306 USA. [Bellar, David] Univ Louisiana Lafayette, Lafayette, LA 70504 USA. [Kamimori, Gary] Walter Reed Army Inst Res, Silver Spring, MD USA. EM lwjudge@bsu.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 923 BP 105 EP 106 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300299 ER PT J AU Warr, BJ Dodd, D Alvar, B Swan, P AF Warr, Bradley J. Dodd, Daniel Alvar, Brent Swan, Pamela TI Effectiveness Of Interval Training In Small Ability Groups To Improve Cardiovascular Fitness SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Warr, Bradley J.] Arizona State Univ, USA, Mesa, AZ USA. [Dodd, Daniel; Alvar, Brent] Chandler Gilbert Community Coll, Mesa, AZ USA. EM bwarr@asu.edu NR 0 TC 0 Z9 0 U1 1 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1031 BP 140 EP 140 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300395 ER PT J AU Bedno, SA Gubata, ME Yi, B Cowan, DN Niebuhr, DW AF Bedno, Sheryl A. Gubata, Marlene E. Yi, Bin Cowan, David N. Niebuhr, David W. TI Specificity of Risk Factors for Selected Overuse Injuries Among Male Army Recruits SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Bedno, Sheryl A.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Gubata, Marlene E.; Yi, Bin; Cowan, David N.; Niebuhr, David W.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM sheryl.bedno@usuhs.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1045 BP 144 EP 144 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300407 ER PT J AU Knapik, JJ Trone, D Brosch, L Hauret, K Grier, T Bullock, SB Jones, B AF Knapik, Joseph J. Trone, Daniel Brosch, Lorie Hauret, Keith Grier, Tyson Bullock, Steve B. Jones, Bruce TI Does Assigning Running Shoes Based on Plantar Shape Reduce Injury Risk? A Meta-Analysis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Knapik, Joseph J.; Hauret, Keith; Grier, Tyson; Bullock, Steve B.; Jones, Bruce] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Brosch, Lorie] 37th Med Grp, Lackland AFB, TX USA. [Trone, Daniel] USN, Hlth Res Ctr, San Diego, CA 92152 USA. EM joseph.knapik@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1048 BP 145 EP 145 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300410 ER PT J AU Crowder, TA Wells, GD Tenace, SJ AF Crowder, Todd A. Wells, G. Damon Tenace, Shawn J. TI The Fitness Continuum: Impact on Military Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Crowder, Todd A.; Wells, G. Damon; Tenace, Shawn J.] US Mil Acad, West Point, NY 10996 USA. EM todd.crowder@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1093 BP 159 EP 159 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300450 ER PT J AU Kane, SF Taylor, JC Anderson, SE Pennardt, AM Cohen, MI AF Kane, Shawn F. Taylor, Jonathan C. Anderson, Stephen E. Pennardt, Andre M. Cohen, Michael I. TI General Medicine - Recurrent Episodes of Pneumonia in a Warrior Athlete SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Kane, Shawn F.; Taylor, Jonathan C.; Anderson, Stephen E.; Pennardt, Andre M.; Cohen, Michael I.] Womack Army Med Ctr, Ft Bragg, NC USA. EM shawn.kane@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1197 BP 191 EP 191 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226300524 ER PT J AU Seay, JF Hasslequist, L Bensel, CK AF Seay, Joseph F. Hasslequist, Leif Bensel, Carolyn K. TI Rifle Carriage Affects Trunk Motion and Pelvis-Trunk Coordination During Running SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Seay, Joseph F.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Hasslequist, Leif; Bensel, Carolyn K.] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1437 BP 273 EP 273 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301093 ER PT J AU Martens, CR Edwards, DG Kenefick, RW AF Martens, Christopher R. Edwards, David G. Kenefick, Robert W. TI The Effect of Prolonged Exercise in the Heat and Subsequent Submaximal Exercise on Markers of Oxidative Stress SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Martens, Christopher R.; Edwards, David G.] Univ Delaware, Newark, DE USA. [Kenefick, Robert W.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1448 BP 277 EP 278 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301104 ER PT J AU Schiffman, JM Gregorczyk, K Hasselquist, L Bensel, CK Frykman, P Adams, A Obusek, JP AF Schiffman, Jeffrey M. Gregorczyk, Karen Hasselquist, Leif Bensel, Carolyn K. Frykman, Peter Adams, Albert Obusek, John P. TI Can A Lower Body Exoskeleton Improve Load-carriage March And Post-march Performance? SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Schiffman, Jeffrey M.; Gregorczyk, Karen; Hasselquist, Leif; Bensel, Carolyn K.; Adams, Albert; Obusek, John P.] Natick Soldier RD&E Ctr, Natick, MA USA. [Frykman, Peter] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM jeffrey.schiffman@us.army.mil NR 0 TC 1 Z9 1 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1464 BP 283 EP 283 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301120 ER PT J AU Wilkinson, DM Blacker, SD Richmond, VL Horner, FE Rayson, MP Spiess, A Knapik, JJ AF Wilkinson, David M. Blacker, Sam D. Richmond, Victoria L. Horner, Fleur E. Rayson, Mark P. Spiess, Anita Knapik, Joseph J. TI Injuries and Injury Risk Factors in British Army Infantry Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Wilkinson, David M.; Blacker, Sam D.; Richmond, Victoria L.; Horner, Fleur E.; Rayson, Mark P.] Optimal Performance Ltd, Bristol, Avon, England. [Spiess, Anita; Knapik, Joseph J.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. EM david@optimalperformance.co.uk NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1465 BP 283 EP 284 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301121 ER PT J AU Sharp, MA Hendrickson, NR Staab, JS McClung, HL Michniak-Kohn, B Catrambone, DE Nindl, BC Adam, GE AF Sharp, Marilyn A. Hendrickson, Nathan R. Staab, Jeffery S. McClung, Holly L. Michniak-Kohn, Bozena Catrambone, Daniel E. Nindl, Bradley C. Adam, Gina E. TI Short-Term Quercetin Supplementation Does Not Improve Aerobically Demanding Soldier Performance SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Sharp, Marilyn A.; Hendrickson, Nathan R.; Staab, Jeffery S.; McClung, Holly L.; Catrambone, Daniel E.; Nindl, Bradley C.; Adam, Gina E.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Michniak-Kohn, Bozena] Rugers State Univ NJ, New Brunswick, NJ USA. EM marilyn.sharp@us.army.mil NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1467 BP 284 EP 284 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301123 ER PT J AU Convertino, VA Hurst, GM Ryan, KL Vyas, N Ward, KR Rickards, CA AF Convertino, Victor A. Hurst, Gennifer M. Ryan, Kathy L. Vyas, Nisarg Ward, Kevin R. Rickards, Caroline A. TI Bleeding Or Active? Validation Of A Machine-learning Algorithm For Remote Determination Of Blood Volume Status SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Convertino, Victor A.; Ryan, Kathy L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hurst, Gennifer M.] Pittsburg Tissue Engn Initiat, Pittsburgh, PA USA. [Vyas, Nisarg] BodyMedia Adv Dev Inc, Pittsburgh, PA USA. [Ward, Kevin R.] Virginia Commonwealth Univ, Reanimat Engn Shock Ctr, Richmond, VA USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX USA. EM victor.convertino@amedd.army.mil NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1470 BP 285 EP 285 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301126 ER PT J AU Frykman, PN Merullo, D Hasselquist, L Gregorczyk, K Banderet, L AF Frykman, Peter N. Merullo, Donna Hasselquist, Leif Gregorczyk, Karen Banderet, Louis TI Exhaustive Whole Body Exercise And Torso Loading Degrades Markmanship SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Frykman, Peter N.; Merullo, Donna; Banderet, Louis] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Hasselquist, Leif; Gregorczyk, Karen] Natick Soldier Res Dev & Engn Ctr, Natick, MA USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1472 BP 286 EP 286 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301128 ER PT J AU Santtila, M Hakkinen, K Nindl, BC Kyrolainen, H AF Santtila, Matti Hakkinen, Keijo Nindl, Bradley C. Kyrolainen, Heikki TI Improvements In Physical Performance During 16 Weeks Of Military Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Santtila, Matti] Finnish Def Forces, Helsinki, Finland. [Hakkinen, Keijo; Kyrolainen, Heikki] Univ Jyvaskyla, Jyvaskyla, Finland. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM matti.santtila@mil.fi NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1473 BP 286 EP 287 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301129 ER PT J AU Nagai, T Sell, TC House, AJ Deluzio, JB Abt, JP Lovalekar, MT Smalley, BW Lephart, SM AF Nagai, Takashi Sell, Timothy C. House, Anthony J. Deluzio, Jennifer B. Abt, John P. Lovalekar, Mita T. Smalley, Brian W. Lephart, Scott M. TI Shoulder Flexibility and Strength Predict Dynamic Pushup Ratio in the 101(st) Airborne Division Soldiers SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 01-05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Nagai, Takashi; Sell, Timothy C.; House, Anthony J.; Deluzio, Jennifer B.; Abt, John P.; Lovalekar, Mita T.; Lephart, Scott M.] Univ Pittsburgh, Pittsburgh, PA USA. [Smalley, Brian W.] USA, St Airborne Div 101, Ft Campbell, KY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1474 BP 287 EP 287 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301130 ER PT J AU Ryan, EJ Jankowski-Wilkinson, A Bellar, DM Kim, CH Muller, MD Russell, M Otterstetter, R Glickman, EL Kamimori, GH AF Ryan, Edward J. Jankowski-Wilkinson, Andrea Bellar, David M. Kim, Chul-Ho Muller, Matthew D. Russell, Morgan Otterstetter, Ronald Glickman, Ellen L. Kamimori, Gary H. TI The Effects of Caffeine Administered in Chewing Gum on Psychomotor Performance Following Acute Bouts of Exhaustive Cycling SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Ryan, Edward J.; Bellar, David M.; Kim, Chul-Ho; Muller, Matthew D.; Glickman, Ellen L.] Kent State Univ, Kent, OH 44242 USA. [Jankowski-Wilkinson, Andrea; Russell, Morgan; Otterstetter, Ronald] Univ Akron, Akron, OH 44325 USA. [Kamimori, Gary H.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1477 BP 288 EP 288 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301133 ER PT J AU Kyrolainen, H Santtila, M Vaara, J Nindl, BC Hakkinen, K AF Kyrolainen, Heikki Santtila, Matti Vaara, Jani Nindl, Bradley C. Hakkinen, Keijo TI IGF-I Is Associated With Fitness And Health Outcomes In A Population Of 846 Young Men SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Kyrolainen, Heikki; Hakkinen, Keijo] Univ Jyvaskyla, Jyvaskyla, Finland. [Santtila, Matti] Finnish Def Forces, Helsinki, Finland. [Vaara, Jani] Natl Def Univ, Helsinki, Finland. [Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM heikki.kyrolainen@jyu.fi NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1639 BP 347 EP 347 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301294 ER PT J AU Goulet, EDB Lamontagne-Lacasse, M Gigou, PY Kenefick, RW Ely, BR Cheuvront, S AF Goulet, Eric D. B. Lamontagne-Lacasse, Martin Gigou, Pierre-Yves Kenefick, Robert W. Ely, Brett R. Cheuvront, Samuel TI Pre-Exercise Hypohydration Effects On Jumping Ability And Muscle Strength, Endurance And Anaerobic Capacity: A Meta-Analysis SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Goulet, Eric D. B.; Lamontagne-Lacasse, Martin; Gigou, Pierre-Yves] Univ Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada. [Kenefick, Robert W.; Ely, Brett R.; Cheuvront, Samuel] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM eric.goulet@usherbrooke.ca NR 0 TC 0 Z9 0 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1681 BP 362 EP 362 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301336 ER PT J AU Armstrong, LE Ganio, MS Lee, EC McDermott, BP Klau, JF Yamamoto, LM Marzano, S Lopez, R Beasley, KN Jimenez, L Le Bellego, L Chevillotte, E Casa, DJ Lieberman, HR AF Armstrong, Lawrence E. Ganio, Matthew S. Lee, Elaine C. McDermott, Bendon P. Klau, Jennifer F. Yamamoto, Linda M. Marzano, Stefania Lopez, Rebecca Beasley, Kathleen N. Jimenez, Liliana Le Bellego, Laurent Chevillotte, Emmanuel Casa, Douglas J. Lieberman, Harris R. TI Degraded Cognitive Performance, Increased Fatigue in Men Following Mild Dehydration at 1.59% Body Mass Loss SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Armstrong, Lawrence E.; Lee, Elaine C.; McDermott, Bendon P.; Klau, Jennifer F.; Yamamoto, Linda M.; Marzano, Stefania; Lopez, Rebecca; Beasley, Kathleen N.; Casa, Douglas J.] Univ Connecticut, Storrs, CT USA. [Ganio, Matthew S.] Texas Hlth Presbyterian Hosp, Dallas, TX USA. [Jimenez, Liliana; Le Bellego, Laurent; Chevillotte, Emmanuel] Danone Res, Palaiseau, France. [Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 0 TC 0 Z9 0 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1686 BP 364 EP 364 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301341 ER PT J AU Vairo, GL Duffey, ML Owens, BD Cameron, KL AF Vairo, Giampietro L. Duffey, Michele L. Owens, Brett D. Cameron, Kenneth L. TI Shoulder Range of Motion Norms within a Young and Physically Active Cohort SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Vairo, Giampietro L.; Duffey, Michele L.] Penn State Univ, University Pk, PA 16802 USA. [Owens, Brett D.; Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA. EM glv103@psu.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1842 BP 418 EP 419 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301497 ER PT J AU Muza, SR Jones, JE Fulco, CS Beidleman, BA Staab, JE AF Muza, Stephen R. Jones, Juli E. Fulco, Charles S. Beidleman, Beth A. Staab, Janet E. TI Erythropoietin Administration Does Not Prevent Cognitive Performance Impairment And Acute Mountain Sickness At 4500 m SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Muza, Stephen R.; Jones, Juli E.; Fulco, Charles S.; Beidleman, Beth A.; Staab, Janet E.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM stephen.muza@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1985 BP 468 EP 468 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301639 ER PT J AU Grier, T Knapik, JJ Swedler, D Jones, BH AF Grier, Tyson Knapik, Joseph J. Swedler, David Jones, Bruce H. TI Association of Fitness and Injuries in Military Services' Basic Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Grier, Tyson; Knapik, Joseph J.; Swedler, David; Jones, Bruce H.] USA, Aberdeen Proving Ground, MD USA. EM Tyson.Grier@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1996 BP 472 EP 472 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301650 ER PT J AU Hauret, KG Campbell, K Jones, BH Taylor, BJ Block, SR Clemmons, NS Nelson, K AF Hauret, Keith G. Campbell, Kerry Jones, Bruce H. Taylor, Bonnie J. Block, Suzanne R. Clemmons, Nakia S. Nelson, Karen TI Sports Injuries In The U.s. Air Force, Marines, And Navy During Deployments For Operation Iraqi Freedom (march 2003-May 2008) SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Hauret, Keith G.; Jones, Bruce H.; Taylor, Bonnie J.; Block, Suzanne R.; Clemmons, Nakia S.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Campbell, Kerry; Nelson, Karen] Natl Def Ctr Energy & Environm, Arlington, VA USA. EM keith.hauret@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 1999 BP 473 EP 473 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301653 ER PT J AU Harvey, TM Gregory, RW Brechue, WF AF Harvey, Travis M. Gregory, Robert W. Brechue, William F. TI Upper-Body Pulling Strength And Work Capacity SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Harvey, Travis M.; Gregory, Robert W.; Brechue, William F.] US Mil Acad, West Point, NY 10996 USA. EM Travis.Harvey@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2089 BP 504 EP 504 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226301743 ER PT J AU Heer, T AF Heer, Todd TI Measuring Muscle Damage And Soreness Following An Army Physical Fitness Test SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Heer, Todd] Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2281 BP 572 EP 572 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302083 ER PT J AU Castellani, JW Chinevere, T Cheuvront, SN Convertino, VA AF Castellani, John W. Chinevere, Troy Cheuvront, Samuel N. Convertino, Victor A. TI Effect Of Inspiratory Resistance On Heart Rate and Dyspnea Following Exercise-heat Stress and 4% Dehydration. SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Castellani, John W.; Chinevere, Troy; Cheuvront, Samuel N.] USARIEM, Natick, MA USA. [Convertino, Victor A.] USA, Inst Surg Res, San Antonio, TX USA. EM john.castellani@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2298 BP 578 EP 578 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302100 ER PT J AU Couchon, BA Combest, T Andrews, A AF Couchon, Bridget A. Combest, Travis Andrews, Anne TI Comparison of Three Different Body Composition Measures in Active Duty Service Members SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Couchon, Bridget A.; Combest, Travis; Andrews, Anne] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2429 BP 623 EP 623 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302230 ER PT J AU Hendrickson, NR Sharp, MA Staab, JS Adam, GE McClung, HL Michniak-Kohn, B Catrambone, DE Nindl, BC AF Hendrickson, Nathan R. Sharp, Marilyn A. Staab, Jeffrey S. Adam, Gina E. McClung, Holly L. Michniak-Kohn, Bozena Catrambone, Daniel E. Nindl, Bradley C. TI Substrate Utilization During Prolonged Sub-maximal Exercise Is Not Changed By Short-term Quercetin Supplementation SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Hendrickson, Nathan R.; Sharp, Marilyn A.; Staab, Jeffrey S.; Adam, Gina E.; McClung, Holly L.; Catrambone, Daniel E.; Nindl, Bradley C.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Michniak-Kohn, Bozena] Rutgers State Univ, Ernest Mario Sch Pharm, New Brunswick, NJ 08903 USA. EM nathan.hendrickson@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2569 BP 672 EP 672 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302371 ER PT J AU Teyhen, DS Usalis, J Cassidy, P Evers, G Odom, R Moore, J Kiesel, K Butler, R Shaffer, S AF Teyhen, Deydre S. Usalis, Jennifer Cassidy, Patricia Evers, Garth Odom, Rachel Moore, Josef Kiesel, Kyle Butler, Robert Shaffer, Scott TI Electromyographic Assessment of the Lumbar Multifidus During Motor Control Exercises in Healthy Adults SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Teyhen, Deydre S.; Usalis, Jennifer; Cassidy, Patricia; Evers, Garth; Odom, Rachel; Moore, Josef; Shaffer, Scott] Baylor Univ, USA, Ft Sam Houston, TX USA. [Kiesel, Kyle; Butler, Robert] Univ Evansville, Evansville, IN USA. EM dteyhen@sbcglobal.net NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2714 BP 723 EP 724 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302515 ER PT J AU Kenefick, RW Sollanek, K Ely, BR Cheuvront, SN Sawka, MN AF Kenefick, Robert W. Sollanek, Kurt Ely, Brett R. Cheuvront, Samuel N. Sawka, Michael N. TI Skin Temperature and Hydration Effects on Vascular Fluid Dynamics During Cycle Exercise SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [Kenefick, Robert W.; Sollanek, Kurt; Ely, Brett R.; Cheuvront, Samuel N.; Sawka, Michael N.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2937 BP 802 EP 802 PG 1 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302737 ER PT J AU O'Brien, C Cadarette, BS AF O'Brien, Catherine Cadarette, Bruce S. TI Quantification of Head Sweating in Desert and Tropic Conditions SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Meeting Abstract CT 57th Annual Meeting of the American-College-Sports-Medicine/Inaugural World Congress on Exercise is Medicine CY JUN 05, 2010 CL Baltimore, MD SP Amer Coll Sports Med C1 [O'Brien, Catherine; Cadarette, Bruce S.] USA, Environm Med Res Inst, Natick, MA 01760 USA. EM kate.obrien@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD MAY PY 2010 VL 42 IS 5 SU 1 MA 2939 BP 802 EP 803 PG 2 WC Sport Sciences SC Sport Sciences GA 759FO UT WOS:000290226302739 ER PT J AU Tsao, CY Hooshangi, S Wu, HC Valdes, JJ Bentley, WE AF Tsao, Chen-Yu Hooshangi, Sara Wu, Hsuan-Chen Valdes, James J. Bentley, William E. TI Autonomous induction of recombinant proteins by minimally rewiring native quorum sensing regulon of E. coli SO METABOLIC ENGINEERING LA English DT Article DE Quorum sensing; AI-2; Recombinant protein expression; Metabolic engineering; Metabolic burden; Systems biology ID GREEN FLUORESCENT PROTEIN; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; AUTOINDUCER AI-2; GENE NETWORKS; IN-SILICO; BIOSYNTHESIS; EXPRESSION; BACTERIA; YEAST AB Quorum sensing (QS) enables an individual bacterium's metabolic state to be communicated to and ultimately control the phenotype of an emerging population. Harnessing the hierarchical nature of this signal transduction process may enable the exploitation of individual cell characteristics to director "program'' entire populations of cells. We re-engineered the native QS regulon so that individual cell signals (autoinducers) are used to guide high level expression of recombinant proteins in E. coli populations. Specifically, the autoinducer-2 (AI-2) QS signal initiates and guides the over expression of green fluorescent protein (GFP), chloramphenicol acetyl transferase (CAT) and beta-galactosidase (LacZ). The new process requires no supervision or input (e.g., sampling for optical density measurement, inducer addition, or medium exchange) and represents a low-cost, high-yield platform for recombinant protein production. Moreover, rewiring a native signal transduction circuit exemplifies an emerging class of metabolic engineering approaches that target regulatory functions. (C) 2010 Elsevier Inc. All rights reserved. C1 [Tsao, Chen-Yu; Hooshangi, Sara; Wu, Hsuan-Chen; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Tsao, Chen-Yu; Wu, Hsuan-Chen; Bentley, William E.] Univ Maryland, Ctr Biosyst Res, Inst Biotechnol, College Pk, MD 20742 USA. [Valdes, James J.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, 2330 Kim Engn Bldg, College Pk, MD 20742 USA. EM bentley@eng.umd.edu OI WU, HSUAN-CHEN/0000-0002-7837-1333 FU National Science Foundation; US Army; Defense Threat Reduction Agency FX Partial support of this work was provided by the National Science Foundation, the US Army, and the Defense Threat Reduction Agency. NR 50 TC 60 Z9 60 U1 1 U2 24 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1096-7176 J9 METAB ENG JI Metab. Eng. PD MAY PY 2010 VL 12 IS 3 BP 291 EP 297 DI 10.1016/j.ymben.2010.01.002 PG 7 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 585JL UT WOS:000276821400011 PM 20060924 ER PT J AU Scorpio, A Chabot, DJ Day, WA Hoover, TA Friedlander, AM AF Scorpio, Angelo Chabot, Donald J. Day, William A. Hoover, Timothy A. Friedlander, Arthur M. TI Capsule depolymerase overexpression reduces Bacillus anthracis virulence SO MICROBIOLOGY-SGM LA English DT Article ID POLY-GAMMA-GLUTAMATE; IDENTIFICATION; GENE AB Capsule depolymerase (CapD) is a gamma-glutamyl transpeptidase and a product of the Bacillus anthracis capsule biosynthesis operon. In this study, we examined the effect of modulating capD expression on B. anthracis capsule phenotype, interaction with phagocytic cells and virulence in guinea pigs. Transcriptional fusions of capD were made to the genes encoding heat-shock protein 60 (hsp60) and elongation factor Tu (EFTu), and to capA, a B. anthracis capsule biosynthesis gene. Translation signals were altered to improve expression of capD, including replacing the putative ribosome-binding site with a consensus sequence and the TTG start codon with ATG. CapD was not detected by immunoblotting in lysates from wild-type B. anthracis Ames but was detected in strains engineered with a consensus ribosome-binding site for capD. Strains overexpressing capD at amounts detected by immunoblotting were found to have less surface-associated capsule and released primarily lower-molecular-mass capsule into culture supernatants. Overexpression of capD increased susceptibility to neutrophil phagocytic killing and adherence to macrophages and resulted in reduced fitness in a guinea pig model of infection. These data suggest that B. anthracis may have evolved weak capD expression resulting in optimized capsule-mediated virulence. C1 [Scorpio, Angelo; Chabot, Donald J.; Day, William A.; Hoover, Timothy A.; Friedlander, Arthur M.] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Scorpio, A (reprint author), Battelle Natl Biodef Inst, Frederick, MD 21702 USA. EM scorpioa@nbacc.net; arthur.friedlander@us.army.mil FU Medical Biological Defense Research Program, US Army Medical Research and Materiel Command [A1_X003_04_RD_B] FX The research described herein was sponsored by the Medical Biological Defense Research Program, US Army Medical Research and Materiel Command, project number A1_X003_04_RD_B. We thank Sarah Norris for her expert statistical analysis. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the US Army. Research was conducted in compliance with the US Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 20 TC 15 Z9 15 U1 1 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 1350-0872 J9 MICROBIOL-SGM JI Microbiology-(UK) PD MAY PY 2010 VL 156 BP 1459 EP 1467 DI 10.1099/mic.0.035857-0 PN 5 PG 9 WC Microbiology SC Microbiology GA 603AL UT WOS:000278180200019 PM 20110296 ER PT J AU Filliung, DR Bower, LM AF Filliung, Dusty R. Bower, Lisa M. TI Medical-Surgical Nursing at the 86th Combat Support Hospital (2007-2009) in Support of Operation Iraqi Freedom: Caring for Host Nation Patients SO MILITARY MEDICINE LA English DT Article AB A descriptive study of the patients admitted to the host nation intermediate care ward (ICW) of the 86th Combat Support Hospital in Baghdad, Iraq was performed. A retrospective chart review was conducted of the patients admitted to the host nation ward between June 2 and September 5, 2008. One hundred and forty host nation patients were included in the study. Patient demographics, origin of admission, length of stay, and disposition of patient are reported. The types of illnesses and injuries most commonly seen as well as the most common surgical procedures are also reported. This study details the nursing care provided to host nation armed forces and civilians during a 3-month period of the deployment of the 86th CSH in Baghdad, Iraq. Information gained from this study is important for predeployment training and readiness of nurses preparing to deploy to Iraq. C1 [Filliung, Dusty R.] Henry Ford Hosp, Div Vasc Surg K8, Detroit, MI 48202 USA. [Bower, Lisa M.] Tripler Army Med Ctr, Tamc, HI 96859 USA. RP Filliung, DR (reprint author), Henry Ford Hosp, Div Vasc Surg K8, 2799 W Grand Ave, Detroit, MI 48202 USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 301 EP 304 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700003 PM 20486499 ER PT J AU Rhon, DI Gill, N Teyhen, D Scherer, M Goffar, S AF Rhon, Daniel I. Gill, Norman Teyhen, Deydre Scherer, Matthew Goffar, Steve TI Clinician Perception of the Impact of Deployed Physical Therapists as Physician Extenders in a Combat Environment SO MILITARY MEDICINE LA English DT Article ID MANAGING-MUSCULOSKELETAL-CONDITIONS; OPERATION-IRAQI-FREEDOM; LOW-BACK-PAIN; DIRECT ACCESS; LUMBAR SPINE; ORTHOPEDIC SURGEONS; DECISION RULES; KNEE; DEGENERATION; EXPERIENCE AB Physical therapists (PTs) serve as physician extenders performing direct access evaluations for musculoskeletal conditions. The previous war-time mission of PTs was limited to level III medical care. Recently PTs began providing care at levels I/II with brigade combat teams (BCTs). Purpose: Determine the sentiment of battlefield providers at levels I/II regarding the operational impact of PTs. Methods: Surveys were provided to BCT medical providers. Results: There were 107 responses (response rate of 51%). According to the responses, PTs made a significant impact on overall mission accomplishment (97%) and patient prognosis (83%) and were considered local experts in musculoskeletal pathology (92%), including the ordering of radiographs (79%). Their presence was thought to significantly decrease medical evacuations within theater (68%) and out of theater (73%). Conclusion: There was a positive sentiment toward PTs in the BCT, suggesting they are highly valued. Future studies need to clarify further operational, medical, and fiscal implications. C1 [Rhon, Daniel I.] Madigan Army Med Ctr, Dept Phys Med & Phys Therapy, Tacoma, WA 98431 USA. [Gill, Norman] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Scherer, Matthew] Univ Maryland, Sch Med, Dept Phys Therapy & Rehabil Sci, Baltimore, MD 21201 USA. [Teyhen, Deydre; Goffar, Steve] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX 78234 USA. RP Rhon, DI (reprint author), Madigan Army Med Ctr, Dept Phys Med & Phys Therapy, Bldg 9040,Fitzimmons Dr, Tacoma, WA 98431 USA. RI Duncan, Kirsty/H-1911-2011 NR 45 TC 5 Z9 5 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 305 EP 312 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700004 PM 20486500 ER PT J AU Yun, HC Blackbourne, LH Jones, JA Holcomb, JB Hospenthal, DR Wolf, SE Renz, EM Murray, CK AF Yun, Heather C. Blackbourne, Lorne H. Jones, John A. Holcomb, John B. Hospenthal, Duane R. Wolf, Steven E. Renz, Evan M. Murray, Clinton K. TI Infectious Complications of Noncombat Trauma Patients Provided Care at a Military Trauma Center SO MILITARY MEDICINE LA English DT Article ID OPERATION-ENDURING-FREEDOM; IRAQI-FREEDOM; RISK-FACTORS; DEATH; OUTCOMES; INJURY AB Infectious complications are reported frequently in combat trauma patients treated at military hospitals. Infections in 4566 noncombat related trauma patients treated at a military trauma center were retrospectively reviewed from 1/2003 to 5/2007 using registry data. Burns, penetrating, and blunt trauma accounted for 17%, 19%, and 64%, respectively; the median age was 38 and 22% were female. Pulmonary infections were present in 4.2% of patients, 2.4% had cellulitis and wound infections, 2.2% urinary infections, and 0.7% sepsis. On univariate analysis, infected patients were more likely to be admitted to the ICU, have longer ICU and hospital lengths of stay (LOS), and to die (p < 0.05). Multivariate analysis revealed associations between infection and hospital LOS, preexisting medical conditions, and lower Glasgow Coma Scale in nonburned patients. In burned patients, infection was associated with total body surface area burned and preexisting conditions (p < 0.01). Enhanced infection control in targeted trauma populations may improve outcomes. C1 [Yun, Heather C.; Hospenthal, Duane R.; Murray, Clinton K.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. [Yun, Heather C.; Hospenthal, Duane R.; Renz, Evan M.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Blackbourne, Lorne H.; Jones, John A.; Wolf, Steven E.; Renz, Evan M.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Holcomb, John B.] Univ Texas Hlth Sci Ctr, Houston, TX USA. RP Yun, HC (reprint author), San Antonio Mil Med Ctr, Ft Sam Houston, TX USA. OI Wolf, Steven/0000-0003-2972-3440 NR 21 TC 6 Z9 8 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 317 EP 323 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700006 PM 20486502 ER PT J AU Bolles, JA Gentlesk, PJ Lewis, PC Ross, RD Eckart, RE AF Bolles, Jonathan A. Gentlesk, Philip J. Lewis, Paul C. Ross, Ronald D. Eckart, Robert E. TI Resource Utilization in the Management of Young Patients With Syncope in a Combat Theater of Operations SO MILITARY MEDICINE LA English DT Article ID EMERGENCY-DEPARTMENT; AMERICAN-COLLEGE; PROGNOSIS; ADMISSION; HISTORY; DISEASE; DEATH; TERM AB Clinical features of young patients presenting with syncope have been underreported. Methods: Retrospective review using U.S. Military Health System's Theater Medical Data Store and Joint Medical Workstation identified patients evaluated for syncope from January 2005 to October 2007 while deployed to a combat zone. Results: We identified 848 patients with syncope. The majority (80.8%) were under the age of 40. The diagnostic yield of the ECG was 2.0%. In those <40 years, there were no head CTs or transthoracic echocardiograms that identified a cause of syncope. There was no difference in evacuation out of theater between those <40 years and those >40 years (10.8% vs. 8.6%, p = 0.08). Patients with a prior episode of syncope were more likely to undergo medical evacuation outside of the combat zone (16.0% vs. 7.7%, p < 0.01). Discussion: Evacuation of those <40 years to facilities with advanced imaging did not add diagnostic information. C1 [Bolles, Jonathan A.; Gentlesk, Philip J.; Lewis, Paul C.; Eckart, Robert E.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Ross, Ronald D.] USA, Ctr Hlth Promot & Preventat Med, Aberdeen Proving Ground, MD 21010 USA. RP Bolles, JA (reprint author), Brooke Army Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 324 EP 328 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700007 PM 20486503 ER PT J AU Wolf, JM Mountcastle, S Burks, R Sturdivant, RX Owens, BD AF Wolf, Jennifer Moriatis Mountcastle, Sally Burks, Robert Sturdivant, Rodney X. Owens, Brett D. TI Epidemiology of Lateral and Medial Epicondylitis in a Military Population SO MILITARY MEDICINE LA English DT Article ID OPERATIVE TREATMENT; PREVALENCE; ELBOW AB Objective: To determine the epidemiology of lateral and medial epicondylitis in the U.S. military. Methods: The Defense Medical Epidemiology Database was queried for ICD-9 codes 726.32 (lateral epicondylitis) and 726.33 (medial epicondylitis) for the years 1998-2006. Multivariate Poisson regression was used to calculate incidence rates (IR) and rate ratios (RR) among demographic groups. Results: The IRs for lateral and medial epicondylitis were 2.98 and 0.81 per 1,000 person-years. For lateral epicondylitis, women had a higher incidence (RR = 1.22, 95% CI 1.19-1.26). In both groups, analysis by age showed higher incidence in the >= 40-year-old group. White compared with black race was a risk factor for both lateral (RR = 1.68, 95% CI, 1.63-1.74) and medial epicondylitis (RR = 1.11, 95% CI 1.05-1.17). Conclusions: Female gender was a risk factor for lateral but not medial epicondylitis. Age greater than 40 and white race were significant risk factors for both conditions. C1 [Wolf, Jennifer Moriatis] Univ Colorado Denver, Dept Orthoped, Aurora, CO 80045 USA. [Mountcastle, Sally] Univ Kansas, Dept Prevent Med & Publ Hlth, Sch Med, Kansas City, KS 66160 USA. [Burks, Robert; Sturdivant, Rodney X.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Owens, Brett D.] Keller Army Hosp, West Point, NY 10996 USA. RP Wolf, JM (reprint author), Univ Colorado Denver, Dept Orthoped, Aurora, CO 80045 USA. RI Burks, Robert/J-2481-2015 OI Burks, Robert/0000-0001-6443-6653 NR 18 TC 13 Z9 14 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 336 EP 339 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700009 PM 20486505 ER PT J AU Hough, D Lewis, P AF Hough, David Lewis, Philip TI A Suicide Prevention Advisory Group at an Academic Medical Center SO MILITARY MEDICINE LA English DT Article ID INPATIENTS; RISK AB During a 15-month period, there were seven suicides among patients who were in active treatment or who had been seen recently by providers in the Department of Psychiatry of Tripler Army Medical Center, Honolulu, Hawaii. As a result, a Suicide Prevention Advisory Group (SPAG) was formed to identify possible causes and make recommendations aimed at improving the identification and treatment of suicidal patients. The group made 11 specific recommendations. No known suicides occurred during the 22 months after the implementation of the Suicide Prevention Advisory Group's recommendations. C1 [Hough, David] Tripler Army Med Ctr, Psychiat Outpatient Serv, Honolulu, HI 96819 USA. [Lewis, Philip] Tripler Army Med Ctr, Dept Psychiat, Honolulu, HI 96819 USA. RP Hough, D (reprint author), Tripler Army Med Ctr, Psychiat Outpatient Serv, 1 Jarrett White Rd, Honolulu, HI 96819 USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 347 EP 351 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700011 PM 20486507 ER PT J AU McCarroll, JE Ursano, RJ Liu, X Thayer, LE Newby, JH Norwood, AE Fullerton, CS AF McCarroll, James E. Ursano, Robert J. Liu, Xian Thayer, Laurie E. Newby, John H. Norwood, Ann E. Fullerton, Carol S. TI Deployment and the Probability of Spousal Aggression by US Army Soldiers SO MILITARY MEDICINE LA English DT Article ID PHYSICAL AGGRESSION; DESERT-STORM; MILITARY; VIOLENCE; PREVALENCE; STRESS; WIVES AB Objective: To determine the relationship between length of soldier deployment and self-reports of moderate and severe spousal violence. Methods: The Conflict Tactics Scale was used to measure self-reports of behaviors exhibited in marital conflict. Surveys were administered to a 15% random sample of 26,835 deployed and nondeployed married active duty U.S. Army men and women in the 50 United States during the period 1990 to 1994. Multinomial logistic regression and ordered probit analysis were used to estimate the probabilities of moderate and severe violence by length of deployment. Results: After controlling for demographic variables, the probability of severe aggression was significantly greater for soldiers who had deployed in the past year compared with soldiers who had not deployed. Conclusions: Deployment contributes a significant but small increase to the probability of self-reported spousal aggression during a 1-year period. Although deployment is a military operation, similar effects may be observed in certain civilian occupations. C1 [McCarroll, James E.; Thayer, Laurie E.; Newby, John H.] Uniformed Serv Univ Hlth Sci, Family Violence & Trauma Project, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA. [McCarroll, James E.; Ursano, Robert J.; Thayer, Laurie E.; Newby, John H.; Norwood, Ann E.; Fullerton, Carol S.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Liu, Xian] Walter Reed Army Med Ctr, Gulf War Hlth Ctr, Washington, DC 20307 USA. RP McCarroll, JE (reprint author), Uniformed Serv Univ Hlth Sci, Family Violence & Trauma Project, Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20814 USA. FU Department of the Army, the Department of Defense; Uniformed Services University of the Health Sciences, Department of Psychiatry FX This research was supported by an interservice support agreement between the Department of the Army, the Department of Defense, and the Uniformed Services University of the Health Sciences, Department of Psychiatry. NR 17 TC 7 Z9 7 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 352 EP 356 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700012 PM 20486508 ER PT J AU Austad, GT Battafarano, DF AF Austad, Gregory T. Battafarano, Daniel F. TI A Returning Traveler With Fever SO MILITARY MEDICINE LA English DT Article ID ONSET STILLS-DISEASE; HEMOPHAGOCYTIC SYNDROME; CYCLOSPORINE-A; ARTHRITIS; THERAPY; MANIFESTATIONS; CLASSIFICATION; FEATURES; CRITERIA AB Active duty military personnel and civilian government employees are at risk for exposure to a variety of pathogens as they meet their mission requirements throughout the world. When they present with a systemic disease, the clinician must entertain a broad differential diagnosis due to the multitude of infectious, neoplastic, and noninfectious inflammatory disorders that can have similar clinical presentations. Since treatment varies significantly, and lack of appropriate therapy may be deadly, the search for the definitive diagnosis should be aggressive and thorough. We present a case of adult-onset Still's disease (AOSD) masquerading as an infectious disease process in a man with recent travel to Sudan. A discussion of the differential diagnosis is included along with a review of the diagnostic criteria, prognosis, and current therapeutic options for AOSD. C1 [Austad, Gregory T.; Battafarano, Daniel F.] Brooke Army Med Ctr, Dept Rheumatol, Ft Sam Houston, TX 78234 USA. RP Austad, GT (reprint author), Brooke Army Med Ctr, Dept Rheumatol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. NR 38 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 362 EP 366 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700014 PM 20486510 ER PT J AU Fisher, JB Curtis, CE AF Fisher, Jeremy B. Curtis, Christopher E. TI An Unexpected Case of Lyme Disease in a Soldier Serving in Northern Iraq SO MILITARY MEDICINE LA English DT Article ID BORRELIA-BURGDORFERI; TRANSMISSION; VECTOR; EUROPE; TICKS; BIRDS AB Lyme disease is a tick-transmitted disease caused by the spirochete Borrelia burgdoferi. Cases have been reported across the United States, Canada, and Europe.(1,2) Additional cases have been described in other parts of the world including Japan, Mexico, and Turkey.(3-5) We report an unexpected case of Lyme disease from Iraq. C1 [Fisher, Jeremy B.] Trop Lightning TMC, Schofield Barracks, HI 96857 USA. RP Fisher, JB (reprint author), Trop Lightning TMC, Bldg 677, Schofield Barracks, HI 96857 USA. NR 13 TC 1 Z9 1 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 2010 VL 175 IS 5 BP 367 EP 369 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 598FH UT WOS:000277819700015 PM 20486511 ER PT J AU Kovdienko, NA Polishchuk, PG Muratov, EN Artemenko, AG Kuz'min, VE Gorb, L Hill, F Leszczynski, J AF Kovdienko, Nikolay A. Polishchuk, Pavel G. Muratov, Eugene N. Artemenko, Anatoly G. Kuz'min, Victor E. Gorb, Leonid Hill, Frances Leszczynski, Jerzy TI Application of Random Forest and Multiple Linear Regression Techniques to QSPR Prediction of an Aqueous Solubility for Military Compounds SO MOLECULAR INFORMATICS LA English DT Article DE Environmental chemistry; Structure-property relationships ID HIERARCHICAL QSAR TECHNOLOGY; PARTITION-COEFFICIENTS; SIMPLEX REPRESENTATION; MOLECULAR-STRUCTURE; ANTIMICROBIAL ACTIVITY; ALKALINE-HYDROLYSIS; ENERGY RELATIONSHIP; ORGANIC-COMPOUNDS; WATER SOLUBILITY; MODELS AB The relationship between the aqueous solubility of more than two thousand eight hundred organic compounds and their structures was investigated using a QSPR approach based on Simplex Representation of Molecular Structure (SiRMS). The dataset consists of 2537 diverse organic compounds. Multiple Linear Regression (MLR) and Random Forest (RF) methods were used for statistical modeling at the 2D level of representation of molecular structure. Statistical characteristics of the best models are quite good (MLR method: R(2)=0.85, Q(2)=0.83; RF method: R(2)=0.99, R(oob)(2)=0.88). The external validation set of 301 compounds (including 47 nitro-, nitroso- and nitrogen-rich compounds of military interest) which were not included in the training set and modeling process, was used for evaluation of the models predictivity. Thus, well-fitted and robust (R(test)(2)(MLR)=0.76 and R(test)(2)(RF)=0.82) models were obtained for both statistical techniques using descriptors based on the topological structural information only. The predicted solubility values for military compounds are in good agreement with experimental ones. Developed QSPR models represent powerful and easy-to-use virtual screening tool that can be recommended for prediction of aqueous solubility. C1 [Gorb, Leonid] SpecPro Inc, Vicksburg, MS 39180 USA. [Kovdienko, Nikolay A.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA. [Polishchuk, Pavel G.; Muratov, Eugene N.; Artemenko, Anatoly G.; Kuz'min, Victor E.] Natl Acad Sci Ukraine, AV Bogatsky Phys Chem Inst, Dept Mol Struct, Lab Theoret Chem, UA-65080 Odessa, Ukraine. [Muratov, Eugene N.] Univ N Carolina, Eshelman Sch Pharm, Dept Med Chem & Nat Prod, Lab Mol Modeling, Chapel Hill, NC 27599 USA. [Hill, Frances; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA. RP Gorb, L (reprint author), SpecPro Inc, Vicksburg, MS 39180 USA. EM lgorb@icnanotox.org RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 FU USAERDC; U.S. Army Engineer Research and Development Center (ERDC) [BT25-08-41] FX The use of trade, product, or firm names in this report is for descriptive purposes only and does not imply endorsement by the U.S. Government. Results in this study were funded and obtained from research conducted under the Environmental Quality Technology Program of the United States Army Corps of Engineers by the USAERDC. The support by the Basic Research Project BT25-08-41 grant from the U.S. Army Engineer Research and Development Center (ERDC) is acknowledged. Permission was granted by the Chief of Engineers to publish this information. The findings of this report are not to be construed as an official Department of the Army position unless so designated by other authorized documents. NR 50 TC 8 Z9 8 U1 0 U2 18 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1868-1743 J9 MOL INFORM JI Mol. Inf. PD MAY PY 2010 VL 29 IS 5 BP 394 EP 406 DI 10.1002/minf.201000001 PG 13 WC Chemistry, Medicinal; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology SC Pharmacology & Pharmacy; Computer Science; Mathematical & Computational Biology GA 608MB UT WOS:000278587200003 PM 27463195 ER PT J AU Bell, RS Ecker, RD Severson, MA Wanebo, JE Crandall, BN Armonda, RA AF Bell, Randy S. Ecker, Robert D. Severson, Meryl A., III Wanebo, John E. Crandall, Benjami N. Armonda, Rocco A. TI The evolution of the treatment of traumatic cerebrovascular injury during wartime SO NEUROSURGICAL FOCUS LA English DT Review DE traumatic vasospasm; endovascular; traumatic aneurysm; penetrating head trauma ID RUPTURED INTRACRANIAL ANEURYSMS; POSTTRAUMATIC CEREBRAL VASOSPASM; MISSILE HEAD WOUNDS; SUBARACHNOID HEMORRHAGE; ENDOVASCULAR COILING; BASILAR ARTERY; TRIAL ISAT; MANAGEMENT; BRAIN; HYPEREMIA AB The approach to traumatic craniocervical vascular injury has evolved significantly in recent years. Conflicts prior to Operations Iraqi and Enduring Freedom were characterized by minimal intervention in the setting of severe penetrating head injury, in large part due to limited far-forward resource availability. Consequently, sequelae of penetrating head injury like traumatic aneurysm formation remained poorly characterized with a paucity of pathophysiological descriptions. The current conflicts have seen dramatic improvements with respect to the management of severe penetrating and closed head injuries. As a result of the rapid field resuscitation and early cranial decompression, patients are surviving longer, which has led to diagnosis and treatment of entities that had previously gone undiagnosed. Therefore, in this paper the authors' purpose is to review their experience with severe traumatic brain injury complicated by injury to the craniocervical vasculature. Historical approaches will be reviewed, and the importance of modern endovascular techniques will be emphasized. (DOI: 10.3171/2010.2.FOCUS1025) C1 [Bell, Randy S.; Ecker, Robert D.; Severson, Meryl A., III; Wanebo, John E.; Armonda, Rocco A.] Univ Hlth Sci, Dept Neurosurg, Bethesda, MD USA. [Crandall, Benjami N.] Univ Hlth Sci, Dept Radiol, Natl Naval Med Ctr, Bethesda, MD USA. [Bell, Randy S.; Ecker, Robert D.; Armonda, Rocco A.] Univ Hlth Sci, Dept Neurosurg, Uniformed Serv, Bethesda, MD USA. [Armonda, Rocco A.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. RP Bell, RS (reprint author), NAVMED MPT&E, Bethesda, MD 20889 USA. EM randy.s.bell@us.army.mil OI Wanebo, John/0000-0003-1833-2938 FU Comprehensive Neurosciences Program FX The Comprehensive Neurosciences Program provided funding for the very early work analyzing the effect of traumatic vasospasm in this population (2004-2005). NR 37 TC 17 Z9 18 U1 0 U2 4 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E5 DI 10.3171/2010.2.FOCUS1025 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600005 PM 20568945 ER PT J AU Bell, RS Mossop, CM Dirks, MS Stephens, FL Mulligan, L Ecker, R Neal, CJ Kumar, A Tigno, T Armonda, RA AF Bell, Randy S. Mossop, Corey M. Dirks, Michael S. Stephens, Frederick L. Mulligan, Lisa Ecker, Robert Neal, Christopher J. Kumar, Anand Tigno, Teodoro Armonda, Rocco A. TI Early decompressive craniectomy for severe penetrating and closed head injury during wartime SO NEUROSURGICAL FOCUS LA English DT Article DE decompressive craniectomy; penetrating head injury; blast injury; Glasgow Outcome Scale ID TRAUMATIC BRAIN-INJURY; CENTRAL-NERVOUS-SYSTEM; WOUNDS AB Object. Decompressive craniectomy has defined this era of damage-control wartime neurosurgery. Injuries that in previous conflicts were treated in an expectant manner are now aggressively decompressed at the far-forward Combat Support Hospital and transferred to Walter Reed Army Medical Center (WRAMC) and National Naval Medical Center (NNMC) in Bethesda for definitive care. The purpose of this paper is to examine the baseline characteristics of those injured warriors who received decompressive craniectomies. The importance of this procedure will be emphasized and guidance provided to current and future neurosurgeons deployed in theater. Methods. The authors retrospectively searched a database for all soldiers injured in Operations Iraqi Freedom and Enduring Freedom between April 2003 and October 2008 at WRAMC and NNMC. Criteria for inclusion in this study included either a closed or penetrating head injury suffered during combat operations in either Iraq or Afghanistan with subsequent neurosurgical evaluation at NNMC or WRAMC. Exclusion criteria included all cases in which primary demographic data could not be verified. Primary outcome data included the type and mechanism of injury, Glasgow Coma Scale (GCS) score and injury severity score (ISS) at admission, and Glasgow Outcome Scale (GOS) score at discharge, 6 months, and 1-2 years. Results. Four hundred eight patients presented with head injury during the study period. In this population, a total of 188 decompressive craniectomies were performed (154 for penetrating head injury, 22 for closed head injury, and 12 for unknown injury mechanism). Patients who underwent decompressive craniectomies in the combat theater had significantly lower initial GCS scores (7.7 +/- 4.2 vs 10.8 +/- 4.0, p < 0.05) and higher ISSs (32.5 +/- 9.4 vs 26.8 +/- 11.8, p < 0.05) than those who did not. When comparing the GOS scores at hospital discharge, 6 months, and 1-2 years after discharge, those receiving decompressive craniectomies had significantly lower scores (3.0 +/- 0.9 vs 3.7 +/- 0.9, 3.5 +/- 1.2 vs 4.0 +/- 1.0, and 3.7 +/- 1.2 vs 4.4 +/- 0.9, respectively) than those who did not undergo decompressive craniectomies. That said, intragroup analysis indicated consistent improvement for those with craniectomy with time, allowing them, on average, to participate in and improve from rehabilitation (p < 0.05). Overall, 83% of those for whom follow-up data are available achieved a 1-year GOS score of greater than 3. Conclusions. This study of the provision of early decompressive craniectomy in a military population that sustained severe penetrating and closed head injuries represents one of the largest to date in both the civilian and military literature. The findings suggest that patients who undergo decompressive craniectomy had worse injuries than those receiving craniotomy and, while not achieving the same outcomes as those with a lesser injury, did improve with time. The authors recommend hemicraniectomy for damage control to protect patients from the effects of brain swelling during the long overseas transport to their definitive care, and it should be conducted with foresight concerning future complications and reconstructive surgical procedures. (DOI: 10.3171/2010.2.FOCUS1022) C1 [Bell, Randy S.; Mossop, Corey M.; Dirks, Michael S.; Stephens, Frederick L.; Mulligan, Lisa; Neal, Christopher J.; Armonda, Rocco A.] Univ Hlth Sci, Uniformed Serv, Bethesda, MD USA. [Bell, Randy S.; Mulligan, Lisa; Ecker, Robert; Neal, Christopher J.; Kumar, Anand; Armonda, Rocco A.] USN, Med Ctr, Dept Neurosurg, Bethesda, MD 20814 USA. [Tigno, Teodoro; Armonda, Rocco A.] Walter Reed Army Med Ctr, Dept Neurosurg, Washington, DC 20307 USA. [Mossop, Corey M.; Dirks, Michael S.; Stephens, Frederick L.; Armonda, Rocco A.] Natl Capital Consortium Neurosurg Program, Washington, DC USA. RP Bell, RS (reprint author), NAVMED MPT&E, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM randy.s.bell@us.army.mil FU University of Texas, Medical Branch FX The authors are thankful for the service of all neurosurgeons deployed during OIF and OEF. They also thank Dr. Alexander H. Vo, Ph. D., from the University of Texas, Medical Branch, for his support with statistical analysis. NR 17 TC 35 Z9 39 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E1 DI 10.3171/2010.2.FOCUS1022 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600001 PM 20568925 ER PT J AU Cannon, JW Teff, RJ AF Cannon, Jeremy W. Teff, Richard J. TI Combat surgeons before, during, and after war: the legacy of Loyal Davis SO NEUROSURGICAL FOCUS LA English DT Article DE Loyal Davis; military neurosurgery; combat casualty care; surgical consultant; lessons learned ID IRAQ AB By 1942, Loyal Davis had firmly established himself as a preeminent civilian neurosurgeon. With military operations rapidly escalating, he was recruited to serve in the European Theater of Operations as a consultant to the Surgeon General. Davis brought tremendous experience, insight, and leadership to this position; however, he found the military system in which he was suddenly immersed inefficient and impassive. His requests for even basic equipment became mired in endless bureaucracy even as his communiques to the Chief Surgeon in the European Theater and to the Surgeon General's staff in Washington seemed to fall short of their intended recipients. Then, when he attempted to vent his frustrations to his academic colleagues, he was nearly court-martialed. Notwithstanding, Davis became the first to formally recognize high-altitude frostbite and also developed protective headgear for airmen, and later in his service, he joined a contingent of senior medical leaders who visited the Soviet Union to study their system of combat casualty care. Subsequent to his service on active duty, Davis returned to his academic practice at Northwestern where he used his position as editor of Surgery, Gynecology, and Obstetrics to advocate for change within the military medical corps. Others like Davis have contributed greatly to the advancement of combat casualty care both during active service and long after their time in uniform. This paper examines the lessons from Davis's experiences as a military neurosurgeon and his continued advocacy for change in the medical corps along with additional recent examples of change effected by former military surgeons. For those currently serving, these lessons illustrate the value of contributing wherever a need is recognized, and for those who have served in the past, they demonstrate the importance of having a continued voice with junior combat surgeons and the military leadership. (DOI: 10.3171/2010.2.FOCUS1024) C1 [Cannon, Jeremy W.] Wilford Hall USAF Med Ctr, Dept Surg, San Antonio, TX 78236 USA. [Teff, Richard J.] Brooke Army Med Ctr, Div Neurosurg, San Antonio, TX USA. RP Cannon, JW (reprint author), 202 Furr Dr, San Antonio, TX 78201 USA. EM jcannon@massmed.org NR 29 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E22 DI 10.3171/2010.2.FOCUS1024 PG 7 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600022 PM 20568939 ER PT J AU Cardoso, MJ Rosner, MK AF Cardoso, Mario J. Rosner, Michael K. TI Multilevel cervical arthroplasty with artificial disc replacement SO NEUROSURGICAL FOCUS LA English DT Article DE cervical arthroplasty; multilevel cervical arthroplasty; Prestige ST; radiculopathy; myelopathy ID INTERBODY FUSION; SPINE SURGERY; DISKECTOMY; MYELOPATHY; ADJACENT; REMOVAL; JOINT; SITE AB Object. In this study, the authors review the technique for inserting the Prestige ST in a contiguous multilevel cervical disc arthroplasty in patients with radiculopathy and myelopathy. They describe the preoperative planning, surgical technique, and their experience with 10 patients receiving a contiguous Prestige ST implant. They present contiguous multilevel cervical arthroplasty as an alternative to multilevel arthrodesis. Methods. After institutional board review approval was obtained, the authors performed a retrospective review of all contiguous multilevel cervical disc arthroplasties with the Prestige ST artificial disc between August 2007 and November 2009 at a single institution by a single surgeon. Clinical criteria included patients who had undergone a multilevel cervical disc arthroplasty performed for radiculopathy and myelopathy without the presence of a previous cervical fusion. Between August 2007 and November 2009, 119 patients underwent cervical arthroplasty. Of the 119 patients, 31 received a Hybrid construct (total disc resection [TDR]-anterior cervical decompression and fusion [ACDF] or TDR-ACDF-TDR) and 24 received a multilevel cervical arthroplasty. The multilevel cervical arthroplasty group consisted of 14 noncontiguous and 10 contiguous implants. This paper examines patients who received contiguous Prestige ST implants. Results. Ten men with an average age of 45 years (range 25-61 years) were treated. Five patients presented with myelopathy, 3 presented with radiculopathy, and 2 presented with myeloradiculopathy. Twenty-two 6 x 16-mm Prestige ST TDRs were implanted. Six patients received 2-level Prestige ST implants. Five patients received TDRs at C5-6 and C6-7, and 1 patient received TDRs at C3-4 and C4-5. One patient received a TDR at C3-4, C5-6, and C6-7 where C4-5 was a congenital block vertebra. Three patients (2 with 3-level disease and 1 with 4-level disease) received contiguous Prestige ST implants as well as a Prevail ACDF as part of their constructs. The mean clinical and radiographic follow-up was 12 months. There has been no case of screw backout, implant dislodgment, progressive kyphosis, formation of heterotopic bone, evidence of pseudarthrosis at the Prevail levels, or development of symptomatic adjacent level disease. Conclusions. Multilevel cervical arthroplasty with the Prestige ST is a safe and effective alternative to fusion for the management of cervical radiculopathy and myelopathy. (DOI: 10.3171/2010.1.FOCUS1031) C1 [Cardoso, Mario J.; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA. RP Cardoso, MJ (reprint author), Walter Reed Army Med Ctr, Neurosurg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM mtcardoso@comcast.net NR 20 TC 27 Z9 37 U1 1 U2 6 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E19 DI 10.3171/2010.1.FOCUS1031 PG 6 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600019 PM 20568935 ER PT J AU Cardoso, MJ Rosner, MK AF Cardoso, Mario J. Rosner, Michael K. TI Does the Wilson frame assist with optimizing surgical exposure for minimally invasive lumbar fusions? SO NEUROSURGICAL FOCUS LA English DT Article DE Wilson frame; minimally invasive technique; lumbar fusion ID BACK MUSCLE INJURY; INTERBODY FUSION; SPINE SURGERY; HISTOCHEMICAL ANALYSES; LORDOSIS; POSITION; MOTION AB Object. Minimally invasive lumbar spine surgery has dramatically evolved over the last decade. Minimally invasive techniques and transforaminal lumbar interbody fusion (TLIF) often require a steep learning curve. Surgical techniques require pre-positioning the patient in maximal kyphosis to optimize visualization of the disc space and prevent unnecessary retraction of neural structures. The authors describe their experience in validating the surgical technique recommendation of Wilson frame-induced kyphosis. Methods. Over the past 6 months, data obtained in 20 consecutive patients (40 total levels) undergoing minimally invasive TLIF were reviewed. In each patient, preincision intraoperative radiographs were reviewed at L4-5 and L5-S1 with the patient on a Wilson frame in maximal lordosis and then in maximal kyphosis. The change in disc space angle at L4-5 and L5-S1 after changing from maximal lordosis to maximal kyphosis was reviewed. Descriptive statistics were calculated for sagittal plane angular measures at L4-5 and L5-S1 in lordosis and kyphosis, including absolute differences and percentage of change between positions. Inferential statistics were calculated using paired t-tests with alpha = 0.05. Results. Twenty patients underwent single- or multilevel minimally invasive TLIF. Inducing kyphosis with the Wilson frame aided in optimizing exposure and decreasing the need for neural structure retraction. Both L4-5 and L5-S1 showed statistically significant (p < 0.001) and clinically meaningful changes with increased segmental flexion in the kyphotic position. At L4-5 the mean increase in flexion was 4.5 degrees (95% CI 2.9-6.0 degrees), representing an average 47% change. The mean increase in flexion at L5-S1 was 3.2 degrees (95% CI 2.3-4.2 degrees), representing an average 20.8% change. In lordosis the mean angle at L4-5 was 10.6 +/- 4.4 degrees and at L5-S1 was 17 +/- 7.0 degrees. In kyphosis the mean angle at L4-5 was 6.1 +/- 4.5 degrees and at L5-S1 was 13.8 +/- 6.5 degrees. Additionally, there was a statistically significant difference (p < 0.05) in percentage of change between the 2 levels, with L4-5 showing a greater change (27% more flexion) between positions, but the absolute mean difference between the levels was small (1.3 degrees). Conclusions. Minimally invasive TLIF is challenging and requires a significant learning curve. The recommended surgical technique of inducing kyphosis with the Wilson frame prior to incision significantly optimizes exposure. The authors' experience demonstrates that this technique is essential when performing minimally invasive lumbar spinal fusions. (DOI: 10.3171/2010.1.FOCUS10325) C1 [Cardoso, Mario J.; Rosner, Michael K.] Walter Reed Army Med Ctr, Neurosurg Serv, Washington, DC 20307 USA. RP Cardoso, MJ (reprint author), Walter Reed Army Med Ctr, Neurosurg Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM mtcardoso@comcast.net NR 21 TC 2 Z9 3 U1 0 U2 1 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E20 DI 10.3171/2010.1.FOCUS10325 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600020 PM 20568937 ER PT J AU Klimo, P Ragel, BT Rosner, M Gluf, W McCafferty, R AF Klimo, Paul, Jr. Ragel, Brian T. Rosner, Michael Gluf, Wayne McCafferty, Randall TI Can surgery improve neurological function in penetrating spinal injury? A review of the military and civilian literature and treatment recommendations for military neurosurgeons SO NEUROSURGICAL FOCUS LA English DT Review DE penetrating spinal injury; spinal gunshot wound; blast injury; military; decompression; laminectomy; outcome ID CORD MISSILE INJURIES; GUNSHOT WOUNDS; CAUDA-EQUINA; CERVICAL-SPINE; RETROSPECTIVE ANALYSIS; BULLET VELOCITY; WAR; MANAGEMENT; LAMINECTOMY; RECOVERY AB Object. Penetrating spinal injury (PSI), although an infrequent injury in the civilian population, is not an infrequent injury in military conflicts. Throughout military history, the role of surgery in the treatment of PSI has been controversial. The US is currently involved in 2 military campaigns, the hallmark of both being the widespread use of various explosive devices. The authors reviewed the evidence for or against the use of decompressive laminectomy to treat PSI to provide a triservice (US Army, Navy, and Air Force) consensus and treatment recommendations for military neurosurgeons and spine surgeons. Methods. A US National Library of Medicine PubMed database search that identified all literature dealing with acute management of PSI from military conflicts and civilian urban trauma centers in the post-Vietnam War period was undertaken. Results. Nineteen retrospective case series (11 military and 8 civilian) met the study criteria. Eleven military articles covered a 20-year time span that included 782 patients who suffered either gunshot or blast-related projectile wounds. Four papers included sufficient data that analyzed the effectiveness of surgery compared with nonoperative management, 6 papers concluded that surgery was of no benefit, 2 papers indicated that surgery did have a role, and 3 papers made no comment. Eight civilian articles covered a 9-year time span that included 653 patients with spinal gunshot wounds. Two articles lacked any comparative data because of treatment bias. Two papers concluded that decompressive laminectomy had a beneficial role, 1 paper favored the removal of intracanal bullets between T-12 and L-4, and 5 papers indicated that surgery was of no benefit. Conclusions. Based on the authors' military and civilian PubMed literature search, most of the evidence suggests that decompressive laminectomy does not improve neurological function in patients with PSI. However, there are serious methodological shortcomings in both literature groups. For this and other reasons, neurosurgeons from the US Air Force, Army, and Navy collectively believe that decompression should still be considered for any patient with an incomplete neurological injury and continued spinal canal compromise, ideally within 24-48 hours of injury; the patient should be stabilized concurrently if it is believed that the spinal injury is unstable. The authors recognize the highly controversial nature of this topic and hope that this literature review and the proposed treatment recommendations will be a valuable resource for deployed neurosurgeons. Ultimately, the deployed neurosurgeon must make the final treatment decision based on his or her opinion of the literature, individual abilities, and facility resources available. (DOI: 10.3171/2010.2.FOCUS1036) C1 [Klimo, Paul, Jr.] 88th Med Grp, Wright Patterson AFB, OH 45433 USA. [Ragel, Brian T.] Oregon Hlth & Sci Univ, Dept Neurol Surg, Portland, OR 97201 USA. [Rosner, Michael] Walter Reed Army Med Ctr, Div Neurosurg, Washington, DC 20307 USA. [Gluf, Wayne] USN, Med Ctr, San Diego, CA 92152 USA. [McCafferty, Randall] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. RP Klimo, P (reprint author), 88th Med Grp, 4881 Sugar Maple Dr, Wright Patterson AFB, OH 45433 USA. EM atomkpnk@yahoo.com NR 48 TC 12 Z9 12 U1 0 U2 6 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E4 DI 10.3171/2010.2.FOCUS1036 PG 11 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600004 PM 20568944 ER PT J AU Neal, CJ Rosner, MK AF Neal, Chris J. Rosner, Michael K. TI Resident learning curve for minimal-access transforaminal lumbar interbody fusion in a military training program SO NEUROSURGICAL FOCUS LA English DT Article DE minimal-access surgery; transforaminal lumbar interbody fusion; resident education; learning curve ID PEDICLE SCREW PLACEMENT; ACCURACY; DISKECTOMY AB Object. Minimal-access transforaminal lumbar interbody fusion (TLIF) has gained popularity as a method of achieving interbody fusion via a posterior-only approach with the aim of minimizing injury to adjacent tissue. While many studies have reported successful outcomes, questions remain regarding the potential learning curve for successfully completing this procedure. The goal of this study, based on a single resident's experience at the only Accreditation Council for Graduate Medical Education-approved neurosurgical training center in the US military, was to determine if there is in fact a significant learning curve in performing a minimal-access TLIF. Methods. The authors retrospectively reviewed all minimal-access TLIFs performed by a single neurosurgical resident between July 2006 and January 2008. Minimal-access TLIFs were performed using a tubular retractor inserted via a muscle-dilating exposure to limit approach-related morbidity. The accuracy of screw placement and operative times were assessed. Results. A single resident/attending team performed 28 minimal-access TLIF procedures. In total, 65 screws were placed at L-2 (1 screw), L-3 (2 screws), L-4 (18 screws), L-5 (27 screws), and S-1 (17 screws) from the resident's perspective. Postoperative CTs were reviewed to determine the accuracy of screw placement. An accuracy of 95.4% (62 of 65) properly placed screws was noted on postoperative imaging. Two screws (at L-5 in the patient in Case 17 and at S-1 in the patient in Case 9) were lateral, and no revision was needed. One screw (at L-4 in Case 24) was 1 mm medial without symptoms or the need for revision. In evaluating the operative times, 2 deformity cases (Grade III spondylolisthesis) were excluded. The average operating time per level in the remaining 26 cases was 113.25 minutes. The average time per level for the first 13 cases was 121.2 minutes; the amount of time decreased to 105.3 minutes for the second group of 13 cases (p = 0.25). Conclusions. In summary, minimal-access TLIF can be safely performed in a training environment without a significant complication rate due to the expected learning curve. (DOI: 10.3171/2010.1.FOCUS1011) C1 [Neal, Chris J.] Natl Naval Med Ctr, Div Neurosurg, Bethesda, MD 20889 USA. [Rosner, Michael K.] Walter Reed Army Med Ctr, Div Neurosurg, Washington, DC 20307 USA. RP Neal, CJ (reprint author), Natl Naval Med Ctr, Div Neurosurg, 8901 Rockville Pike, Bethesda, MD 20889 USA. EM chrisjneal@verizon.net NR 19 TC 13 Z9 15 U1 0 U2 0 PU AMER ASSOC NEUROLOGICAL SURGEONS PI ROLLING MEADOWS PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA SN 1092-0684 J9 NEUROSURG FOCUS JI Neurosurg. Focus PD MAY PY 2010 VL 28 IS 5 AR E21 DI 10.3171/2010.1.FOCUS1011 PG 4 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 589ZU UT WOS:000277193600021 PM 20568938 ER EF