FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Lalliss, SJ Branstetter, JG AF Lalliss, S. J. Branstetter, J. G. TI The use of three types of suture and stainless steel wire tension banding for the fixation of simulated olecranon fractures A COMPARISON STUDY IN CADAVER ELBOWS SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME LA English DT Article ID DISPLACED FRACTURES; COMPLICATIONS AB Using an osteotomy of the olecranon as a model of a transverse fracture in 22 cadaver elbows we determined the ability of three different types of suture and stainless steel wire to maintain reduction when using a tension-band technique to stabilise the bone. Physiological cyclical loading simulating passive elbow movement (15 N) and using the arms to push up from a chair (450 N) were applied using an Instron materials testing machine whilst monitoring the osteotomy site with a video extensometer. Each osteotomy was repaired by one of four materials, namely, Stainless Steel Wire (7), No 2 Ethibond (3), No 5 Ethibond (5), or No 2 FiberWire (7). There were no failures (movement of > 2 mm) with stainless steel wire or FiberWire and no significant difference in the movements measured across the site of the osteotomy (p = 0.99). The No. 2 Ethibond failed at 450 N and two of the five of No. 5 Ethibond sutures had a separation of > 2 mm at 450 N. FiberWire as the tension band in this model held the reduction as effectively as stainless steel wire and may reduce the incidence of discomfort from the hardware. On the basis of our findings we suggest that a clinical trial should be undertaken RP Branstetter, JG (reprint author), USA, Inst Surg Res, 3400 Rawley Chambers Rd, Ft Sam Houston, TX 78234 USA. EM Joanna.Branstetter@amedd.army.mil NR 19 TC 11 Z9 13 U1 0 U2 4 PU BRITISH EDITORIAL SOC BONE JOINT SURGERY PI LONDON PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND SN 0301-620X J9 J BONE JOINT SURG BR JI J. Bone Joint Surg.-Br. Vol. PD FEB PY 2010 VL 92B IS 2 BP 315 EP 319 DI 10.1302/0301-620X.92B2.22596 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 551XN UT WOS:000274246800025 PM 20130331 ER PT J AU Wu, JR Lennie, TA De Jong, MJ Frazier, SK Heo, S Chung, ML Moser, DK AF Wu, Jia-Rong Lennie, Terry A. De Jong, Marla J. Frazier, Susan K. Heo, Seongkum Chung, Misook L. Moser, Debra K. TI Medication Adherence is a Mediator of the Relationship Between Ethnicity and Event-Free Survival in Patients With Heart Failure SO JOURNAL OF CARDIAC FAILURE LA English DT Article DE Medication adherence; heart failure; outcomes; ethnicity; mediator ID QUALITY-OF-CARE; LEFT-VENTRICULAR DYSFUNCTION; AFRICAN-AMERICANS; RACIAL-DIFFERENCES; ELDERLY-PATIENTS; CHRONIC DISEASE; HEALTH; OUTCOMES; THERAPY; RACE AB Background: Rehospitalization rates are higher in African American than Caucasian patients with heart failure (HF). The reasons for the disparity in outcomes between African Americans and Caucasians may relate to differences in medication adherence. To determine whether medication adherence is a mediator of the relationship between ethnicity and event-free survival in patients with HF. Methods and Results: Medication adherence was monitored longitudinally in 135 HF patients using the Medication Event Monitoring System. Events (emergency department visits for HF exacerbation, HF and cardiac rehospitalization, and all-cause mortality) were obtained by interview and hospital data base review. A series of regression models and survival analyses was conducted to determine whether medication adherence mediated the relationship between ethnicity and event-free survival. Event-free survival was significantly worse in African Americans than Caucasians. Ethnicity was a predictor of medication adherence (P = .011). African Americans were 2.57 times more likely to experience an event than Caucasians (P = .026). Ethnicity was not a predictor of event-free survival after entering medication adherence in the model (P = .06). Conclusions: Medication adherence was a mediator of the relationship between ethnicity and event-free survival in this sample. Interventions designed to reduce barriers to medication adherence may decrease the disparity in outcomes. (J Cardiac Fail 2010;16:142-149) C1 [Wu, Jia-Rong; Lennie, Terry A.; Frazier, Susan K.; Chung, Misook L.; Moser, Debra K.] Univ Kentucky, Coll Nursing, Lexington, KY 40536 USA. [De Jong, Marla J.] USA, DoD Blast Injury Res Program Coordinating Off, Res & Mat Command, Ft Detrick, MD USA. [Heo, Seongkum] Indiana Univ, Sch Nursing, Indianapolis, IN 46204 USA. RP Wu, JR (reprint author), Univ Kentucky, Coll Nursing, 509 CON Bldg,760 Rose St, Lexington, KY 40536 USA. EM jiarongwu@uky.edu FU Philips Medical-American Association; University of Kentucky General Clinical Research Center [M01RR02602]; American Heart Association; National Institute of Nursing Research [R01 NR008567]; NIH, NINR [1P20NR010679] FX Supported by funding from the Philips Medical-American Association of Critical Care Nurses Outcomes Grant, University of Kentucky General Clinical Research Center (M01RR02602), American Heart Association Great River Affiliate Post-doctoral Fellowship to Jia-Rong Wu, grant #R01 NR008567 from the National Institute of Nursing Research and a Center grant to the University of Kentucky, College of Nursing from NIH, NINR, 1P20NR010679. NR 84 TC 20 Z9 20 U1 2 U2 4 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI PHILADELPHIA PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA SN 1071-9164 J9 J CARD FAIL JI J. Card. Fail. PD FEB PY 2010 VL 16 IS 2 BP 142 EP 149 DI 10.1016/j.cardfail.2009.10.017 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 594ZZ UT WOS:000277581800008 PM 20142026 ER PT J AU Laczek, JT Shrestha, M Kortan, ND Lake, JM AF Laczek, Jeffrey T. Shrestha, Merica Kortan, Nicholas D. Lake, Jason M. TI Carbamazepine-induced Pancreatitis With Positive Rechallenge SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Letter C1 [Laczek, Jeffrey T.; Shrestha, Merica; Kortan, Nicholas D.; Lake, Jason M.] Walter Reed Army Med Ctr, Dept Med, Georgia, WA USA. RP Laczek, JT (reprint author), Walter Reed Army Med Ctr, Dept Med, Georgia, WA USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD FEB PY 2010 VL 44 IS 2 BP 153 EP 154 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 546WT UT WOS:000273846000016 PM 19636258 ER PT J AU Rickards, CA Ryan, KL Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Convertino, Victor A. TI CHARACTERIZATION OF COMMON MEASURES OF HEART PERIOD VARIABILITY IN HEALTHY HUMAN SUBJECTS: IMPLICATIONS FOR PATIENT MONITORING SO JOURNAL OF CLINICAL MONITORING AND COMPUTING LA English DT Article DE heart rate; heart period variability; ECG; electrocardiography; reliability and validity; reproducibility of results; reference values AB Objective. Heart period variability has been considered for clinical assessment of autonomic function, determining the presence of haemorrhage or disease states, and for predicting mortality from traumatic injury. However, for heart period variability to be clinically useful, a number of important methodological issues should be addressed, including the minimum number of R-R intervals (RRI) required for accurate derivation, and the reproducibility of these metrics. Methods. ECGs were recorded for >= 10 min in 18 resting, supine subjects (12 M/6 F; 19-55 years). Heart period variability analyses included 21 time, frequency and complexity domain metrics. For assessment of minimum RRIs required, measurements were made from ECG recordings of 5 min down to 30 s for time and frequency domain metrics, and from 800 RRIs down to 100 RRIs for complexity metrics, by methodical truncation of the data set. Inter-subject variability was assessed by calculating the range and co-efficient of variation (%CV) across all subjects. Two independent 30 s or 100 RRI ECG segments were used to assess intra-subject variability via calculation of %CV in each subject. Results. Six time and frequency domain metrics were robust down to 30 s of data, while five complexity metrics were robust down to 100 RRIs. All time and frequency domain metrics (except for RRI) exhibited high inter-subject variability (CVs >= 30.0%), while five of eleven complexity metrics displayed low inter-subject variability (CVs <= 8.5%). In the assessment of intra-subject variability in metrics valid with 30 s or 100 RRIs of ECG, only one time domain and four complexity metrics had CVs <10%. Conclusions. Metrics that are highly reproducible and require few RRIs are advantageous for patient monitoring as less time is required to assess physiological status and initiate early interventions. Based on our analyses from healthy, resting humans, we have identified a select cohort of heart period variability metrics that performed well in regards to these two criteria. C1 [Rickards, Caroline A.; Ryan, Kathy L.; Convertino, Victor A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA. RP Rickards, CA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM caroline.rickards@us.army.mil NR 57 TC 11 Z9 11 U1 0 U2 3 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1387-1307 EI 1573-2614 J9 J CLIN MONIT COMPUT JI J. Clin. Monitor. Comp. PD FEB PY 2010 VL 24 IS 1 BP 61 EP 70 DI 10.1007/s10877-009-9210-z PG 10 WC Anesthesiology SC Anesthesiology GA V20PG UT WOS:000208151300005 PM 20157801 ER PT J AU Gaire, C Clemmer, PC Li, HF Parker, TC Snow, P Bhat, I Lee, S Wang, GC Lu, TM AF Gaire, C. Clemmer, P. C. Li, H. -F. Parker, T. C. Snow, P. Bhat, I. Lee, S. Wang, G. -C. Lu, T. -M. TI Small angle grain boundary Ge films on biaxial CaF2/glass substrate SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE Crystal structure; X-ray diffraction; Physical vapor deposition processes; Germanium; Biaxial texture ID GERMANIUM FILMS; GROWTH; CAF2/SI(111); TEMPERATURE; DEPOSITION; MECHANISM; FLUORIDE; EPITAXY; LAYERS AB We demonstrated that it is possible to grow single crystal-like Ge films on a glass substrate using a biaxially textured CaF2 buffer layer at a low temperature of similar to 400 degrees C. The CaF2 buffer layer with the (1 1 1) < 1 2 1 > biaxial orientation was grown by the oblique angle deposition technique and characterized by X-ray pole figure analysis. Transmission electron microscopy revealed that the Ge(1 1 1) heteroepitaxial films possess a single crystal-like structure with small angle grain boundaries of <= 2 degrees misorientation. (C) 2009 Elsevier B.V. All rights reserved. C1 [Gaire, C.; Clemmer, P. C.; Li, H. -F.; Parker, T. C.; Snow, P.; Wang, G. -C.; Lu, T. -M.] Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, Troy, NY 12180 USA. [Bhat, I.] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Lee, S.] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Gaire, C (reprint author), Rensselaer Polytech Inst, Dept Phys Appl Phys & Astron, 110 8th St, Troy, NY 12180 USA. EM gairec@rpi.edu RI Gaire, Churamani/F-1308-2010 NR 26 TC 22 Z9 22 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD FEB 1 PY 2010 VL 312 IS 4 BP 607 EP 610 DI 10.1016/j.jcrysgro.2009.11.051 PG 4 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 558RD UT WOS:000274761900021 ER PT J AU Deng, A Martin, DB Spillane, A Chwalek, J Surin-Lord, SS Brooks, S Petrali, J Sina, B Gaspari, A Kao, G AF Deng, A. Martin, D. Bilu Spillane, A. Chwalek, J. Surin-Lord, S. St. Brooks, Sara Petrali, John Sina, B. Gaspari, A. Kao, G. TI Nephrogenic systemic fibrosis with a spectrum of clinical and histopathological presentation: a disorder of aberrant dermal remodeling SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID OF-THE-LITERATURE; DERMOPATHY; GADOLINIUM; ERYTHROPOIETIN; INVOLVEMENT AB Background: Nephrogenic fibrosing dermopathy (NFD) has emerged as a clinicopathologic entity since 1997 and recently renamed as nephrogenic systemic fibrosis (NSF). The etiology and pathogenesis remain uncertain. Characteristic clinical presentation is described as diffuse thickening and hardening of the skin occurring in patients with renal insufficiency. Typical histological features include proliferation of CD34 positive fibrocytes, increased thick collagen bundles and mucin deposition, without significant inflammatory infiltrate. Variations in clinical presentations have been reported, including papular and plaque-like skin lesions, focal lesion only, as well as systemic involvement. Histological changes can be subtle and non-specific, overlapping with other disease processes and harboring features including calcification and osteoclast-like giant cells with osseous metaplasia. Methods: We reviewed patients with NSF that presented to our dermatology clinic by chart review, clinical examination and histological examination. Skin biopsy specimens were obtained from all cases. Histopathology evaluations were carried out by three dermatopathologists (AD, BS and GK) independently and the features were compared among all the cases. Special stains and immunohistochemistry study were also performed to highlight the histological features. Results: Seven cases of NSF presented with a spectrum of clinical manifestations, from classic diffuse hardening of the skin to localized linear plaques. On histological examination, proliferation of CD34-positive fibrocytes ranged from sparse to dense, collagen bundles ranged from thin to thick, and the interstitial dermal mucin accumulation ranged from scant-patchy to abundant. In addition, the lesion displayed various degrees of vascular proliferation, inflammatory infiltrates and intensities of CD68 and Factor XIIIa staining. Two cases showed extensive dermal calcification and ossification. Conclusion: NSF may present with a spectrum of clinical abnormalities, and exhibit overlapping histopathological features resembling cicatrix and other dermal reparative/regenerative processes. NSF may in fact to be a disorder of aberrant extracellular matrix remodeling in patients with renal insufficiency. Deng A, Bilu Martin D, Spillane A, Chwalek J, St. Surin-Lord S, Brooks S, Petrali J, Sina B, Gaspari A, Kao G. Nephrogenic systemic fibrosis with a spectrum of clinical and histopathological presentation: a disorder of aberrant dermal remodeling. C1 [Deng, A.; Martin, D. Bilu; Spillane, A.; Chwalek, J.; Sina, B.; Gaspari, A.] Univ Maryland, Sch Med, Dept Dermatol, Baltimore, MD 21201 USA. [Kao, G.] VA Maryland Healthcare Syst, Dept Pathol & Lab Med, Baltimore, MD USA. [Surin-Lord, S. St.; Brooks, Sara] Georgetown Univ, Sch Med, Dept Dermatol, Washington, DC USA. [Petrali, John] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Deng, A (reprint author), Univ Massachusetts, Sch Med, Biotech 3,1 Innovat Dr, Worcester, MA 01605 USA. EM denga@ummhc.org NR 15 TC 13 Z9 13 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD FEB PY 2010 VL 37 IS 2 BP 204 EP 210 DI 10.1111/j.1600-0560.2009.01301.x PG 7 WC Dermatology; Pathology SC Dermatology; Pathology GA 533ZN UT WOS:000272865300003 PM 19341434 ER PT J AU Rutkowski, L Vasterling, JJ Proctor, SP Anderson, CJ AF Rutkowski, Leslie Vasterling, Jennifer J. Proctor, Susan P. Anderson, Carolyn J. TI Posttraumatic Stress Disorder and Standardized Test-Taking Ability SO JOURNAL OF EDUCATIONAL PSYCHOLOGY LA English DT Article DE standardized testing; posttraumatic stress disorder; test taking ID MENTAL-HEALTH PROBLEMS; PSYCHOMETRIC PROPERTIES; INTELLECTUAL RESOURCES; VIOLENCE EXPOSURE; VIETNAM VETERANS; PTSD CHECKLIST; SYMPTOMS; SOLDIERS; MODELS; MEMORY AB Given the widespread use and high-stakes nature of educational standardized assessments. understanding factors that affect test-taking ability in young adults is vital. Although scholarly attention has often focused on demographic factors, (e.g., gender and race), sufficiently prevalent acquired characteristic,, may also help explain widespread individual differences on standardized tests. In particular, this article focuses on the role that posttraumatic stress symptoms (PSS) potentially play in standardized academic assessments. Using a military sample measured before and after exposure to war-zone stressors, the authors sought to explain test-taking ability differences with respect to symptoms of PTSD on two cognitive tasks that closely match standardized test constructs. The primary method for this analysis is based on an item response theory with covariates approach. Findings suggest that the effect for PSS is significant on both tasks, particularly for those who experience the highest levels of PSS following war-zone exposure. Findings provide potentially valuable information regarding the nature of the relationship between PSS and verbal and logical reasoning test performance. C1 [Rutkowski, Leslie; Anderson, Carolyn J.] Univ Illinois, Dept Educ Psychol, Urbana, IL 61801 USA. [Rutkowski, Leslie; Vasterling, Jennifer J.; Proctor, Susan P.] VA Boston Healthcare Syst, Boston, MA USA. [Vasterling, Jennifer J.] Boston Univ, Sch Med, Boston, MA 02215 USA. [Proctor, Susan P.] USA, Inst Environm Med, Natick, MA 01760 USA. RP Rutkowski, L (reprint author), Int Assoc Evaluat Educ Achievement, Data Proc & Res Ctr, Mexikoring 37, D-22297 Hamburg, Germany. EM leslie.rutkowski@iea-dpc.de NR 61 TC 2 Z9 2 U1 2 U2 6 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-0663 J9 J EDUC PSYCHOL JI J. Educ. Psychol. PD FEB PY 2010 VL 102 IS 1 BP 223 EP 233 DI 10.1037/a0017287 PG 11 WC Psychology, Educational SC Psychology GA 551OF UT WOS:000274218200017 ER PT J AU Peters, JF Berney, ES AF Peters, John F. Berney, Ernest S. TI Percolation Threshold of Sand-Clay Binary Mixtures SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article ID MECHANICAL-PROPERTIES; STATIC LIQUEFACTION; GRANULAR SOILS; STRESS; TRANSITION; STRENGTH; BEHAVIOR; MEDIA AB Many poorly graded granular materials of engineering importance can be characterized as gap-graded binary mixtures. Such mixtures display a volume-change response at a threshold value of the coarse fraction that is reminiscent of systems described by percolation theory. An experimental investigation on a sand-clay mixture is presented that clearly displays threshold behavior and sheds light on the role that each soil fraction plays in transferring loads through the medium. There are two key effects. First, an analysis of void ratio of the interpore clay fraction for varying compaction energies reveals an abrupt reduction in clay density at the threshold fraction of sand, whereby it is virtually impossible to impart compaction on the clay fraction at sand contents exceeding this threshold. Second, although force chains cannot be observed directly, analysis of the sand in terms of its component void ratio, computed based on treating the clay as part of the void space, shows that the sand carries a majority of the load at component void ratios that are too high to form stable force chains. The traditional interrelationship between mean stress and void ratio based on critical state theory breaks down when the sand content nears its threshold fraction. When the sand content is near the threshold limit, increasing mean stress results in a greater dilative tendency. Results are compared with findings on consolidation of sand-bentonite mixtures, and so-called reverse behavior of sand-silt mixtures. C1 [Peters, John F.; Berney, Ernest S.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Berney, ES (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ernest.s.berney.iv@usace.army.mil NR 30 TC 11 Z9 11 U1 0 U2 18 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD FEB PY 2010 VL 136 IS 2 BP 310 EP 318 DI 10.1061/(ASCE)GT.1943-5606.0000211 PG 9 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 544QO UT WOS:000273674100004 ER PT J AU Gibson, S Abraham, D Heath, R Schoellhamer, D AF Gibson, Stanford Abraham, David Heath, Ronald Schoellhamer, David TI Bridging Process Threshold for Sediment Infiltrating into a Coarse Substrate SO JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING LA English DT Article ID GRAVEL BED; FINE; FILTERS; SAND AB Sand infiltration into gravel frameworks poses significant engineering and ecological difficulties. Ten flume experiments were conducted to quantify a sand bridging threshold in a static gravel bed. The D(15 substrate)/d(85 sand) ratio was computed for each of 37 unique sand-substrate pairs and the data were plotted, with previously published flume data, to determine the threshold between bridging and unimpeded static percolation. The process threshold boundary between bridging and unimpeded static percolation fell in the range of 12 < D(15 substrate)/d(85 sand)< 14, substantially higher than predicted by standard geotechnical filter criteria. Plotting the results against the critical constriction size of the substrates provided a more definitive process separation along the line D(c)(*)/d(85)=3. C1 [Gibson, Stanford] USA, Hydrol Engn Ctr, Corps Engineers, Davis, CA 95616 USA. [Schoellhamer, David] Univ Calif Davis, Dept Civil & Environm Engn, Davis, CA 95616 USA. [Abraham, David; Heath, Ronald] USA, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA. RP Gibson, S (reprint author), USA, Hydrol Engn Ctr, Corps Engineers, Davis, CA 95616 USA. EM stanfordgibson@hotmail.com FU U.S. Army Corps of Engineers' System-Wide Water Resources Program (SWWRP) FX This work was funded through the U.S. Army Corps of Engineers' System-Wide Water Resources Program (SWWRP). Bill Katzenmeyer and John Evans assisted with flume maintenance and experimental setup. The manuscript improved significantly as the result of the careful work Editor Labuz and of two anonymous reviewers. NR 18 TC 8 Z9 8 U1 1 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1090-0241 J9 J GEOTECH GEOENVIRON JI J. Geotech. Geoenviron. Eng. PD FEB PY 2010 VL 136 IS 2 BP 402 EP 406 DI 10.1061/(ASCE)GT.1943-5606.0000219 PG 5 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 544QO UT WOS:000273674100012 ER PT J AU Ake, JA Massung, RF Whitman, TJ Gleeson, TD AF Ake, Julie A. Massung, Robert F. Whitman, Timothy J. Gleeson, Todd D. TI Difficulties in the diagnosis and management of a US servicemember presenting with possible chronic Q fever SO JOURNAL OF INFECTION LA English DT Article DE Q fever; Endocarditis; Mitral regurgitation; Coxiella burnetii ID FOLLOW-UP; ENDOCARDITIS; MILITARY; FATIGUE; IRAQ AB A 34 year old corpsman developed acute Q fever upon return from Iraq. Subsequent testing demonstrated trace mitral regurgitation and widely discrepant serologic testing results between commercial and reference laboratories. We discuss the dilemma of isolated minor echocardiographic abnormalities and propose caution in the interpretation of Q fever serologic tests. Published by Elsevier Ltd on behalf of The British Infection Society. C1 [Ake, Julie A.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Massung, Robert F.] Ctr Dis Control & Prevent, Rickettsial Zoonoses Branch, Div Viral & Rickettsial Dis, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA. [Whitman, Timothy J.; Gleeson, Todd D.] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD 20889 USA. RP Ake, JA (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM julie.ake@amedd.army.mil NR 13 TC 11 Z9 11 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND SN 0163-4453 J9 J INFECTION JI J. Infect. PD FEB PY 2010 VL 60 IS 2 BP 175 EP 177 DI 10.1016/j.jinf.2009.09.010 PG 3 WC Infectious Diseases SC Infectious Diseases GA 552IH UT WOS:000274282400013 PM 19766138 ER PT J AU Mazumder, S Pandey, S Brewer, S Baselski, V Weina, P Land, M Fleckenstein, J AF Mazumder, S. Pandey, S. Brewer, S. Baselski, V. Weina, P. Land, M. Fleckenstein, J. TI LINGUAL LEISHMANIASIS COMPLICATING VISCERAL DISEASE SO JOURNAL OF INVESTIGATIVE MEDICINE LA English DT Meeting Abstract CT Southern Regional Meeting 2010 CY FEB 25-27, 2010 CL New Orleans, LA SP SSCI, SAFMR, SSPR, SSGIM, APA C1 [Mazumder, S.; Pandey, S.; Brewer, S.; Baselski, V.; Land, M.; Fleckenstein, J.] Univ Tennessee, Hlth Sci Ctr, Memphis, TN USA. [Weina, P.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RI Weina, Peter/A-2120-2011 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1081-5589 J9 J INVEST MED JI J. Invest. Med. PD FEB PY 2010 VL 58 IS 2 MA 177 BP 406 EP 407 PG 2 WC Medicine, General & Internal; Medicine, Research & Experimental SC General & Internal Medicine; Research & Experimental Medicine GA 555HL UT WOS:000274499600183 ER PT J AU Grujicic, M Bell, WC Arakere, G He, T Xie, X Cheeseman, BA AF Grujicic, M. Bell, W. C. Arakere, G. He, T. Xie, X. Cheeseman, B. A. TI Development of a Meso-Scale Material Model for Ballistic Fabric and Its Use in Flexible-Armor Protection Systems SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE LA English DT Article DE ballistic performance; flexible armor; high-performance fibers; meso-scale unit-cell material model ID FINITE-DEFORMATION THEORY; PLAIN-WEAVE FABRICS; WOVEN FABRICS; IMPACT; FRICTION; SIMULATION; BEHAVIOR AB A meso-scale ballistic material model for a prototypical plain-woven single-ply flexible armor is developed and implemented in a material user subroutine for the use in commercial explicit finite element programs. The main intent of the model is to attain computational efficiency when calculating the mechanical response of the multi-ply fabric-based flexible-armor material during its impact with various projectiles without significantly sacrificing the key physical aspects of the fabric microstructure, architecture, and behavior. To validate the new model, a comparative finite element method analysis is carried out in which: (a) the plain-woven single-ply fabric is modeled using conventional shell elements and weaving is done in an explicit manner by snaking the yarns through the fabric and (b) the fabric is treated as a planar continuum surface composed of conventional shell elements to which the new meso-scale unit-cell based material model is assigned. The results obtained show that the material model provides a reasonably good description for the fabric deformation and fracture behavior under different combinations of fixed and free boundary conditions. Finally, the model is used in an investigation of the ability of a multi-ply soft-body armor vest to protect the wearer from impact by a 9-mm round nose projectile. The effects of inter-ply friction, projectile/yarn friction, and the far-field boundary conditions are revealed and the results explained using simple wave mechanics principles, high-deformation rate material behavior, and the role of various energy-absorbing mechanisms in the fabric-based armor systems. C1 [Grujicic, M.; Bell, W. C.; Arakere, G.; He, T.; Xie, X.] Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this paper is based on work supported by the U. S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042. The authors are indebted to Dr. Fred Stanton for the support and a continuing interest in the present work. NR 28 TC 23 Z9 23 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1059-9495 J9 J MATER ENG PERFORM JI J. Mater. Eng. Perform. PD FEB PY 2010 VL 19 IS 1 BP 22 EP 39 DI 10.1007/s11665-009-9419-5 PG 18 WC Materials Science, Multidisciplinary SC Materials Science GA 544OM UT WOS:000273667600004 ER PT J AU Lim, J Zheng, JQ Masters, K Chen, WNW AF Lim, Jaeyoung Zheng, James Q. Masters, Karl Chen, Weinong W. TI Mechanical behavior of A265 single fibers SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID ANISOTROPIC FIBRE MONOFILAMENTS; PULSE SHAPING TECHNIQUES; HOPKINSON PRESSURE BAR; TRANSVERSE COMPRESSION; MODULUS; TENSILE; FILAMENTS; FRACTURE; BUNDLES AB The mechanical behavior of A265 high-performance fibers was experimentally investigated at both low and high strain rates. Axial, transverse, and torsional experiments were performed to measure the five material constants on a single fiber assumed as a linear, transversely isotropic material. In order to determine the tensile response of the fiber at high rates, a modified Kolsky tensile bar, also known as a split Hopkinson tension bar (SHTB) for single-fiber tests, was used. The diameter of each fiber was measured individually using a high-resolution scanning electron microscope for accurate stress calculation. A pulse shaper technique was adopted to generate a smooth and constant-amplitude incident pulse to produce deformation in the fiber specimen at a nearly constant strain rate. The tensile strength of the fiber exhibits both rate and gage-length effects. C1 [Lim, Jaeyoung; Chen, Weinong W.] Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. [Zheng, James Q.; Masters, Karl] USA, PM Soldier Equipment, Haymarket, VA 20169 USA. [Lim, Jaeyoung; Chen, Weinong W.] Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA. RP Chen, WNW (reprint author), Purdue Univ, Sch Aeronaut & Astronaut, W Lafayette, IN 47907 USA. EM wchen@purdue.edu NR 26 TC 24 Z9 24 U1 0 U2 21 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 EI 1573-4803 J9 J MATER SCI JI J. Mater. Sci. PD FEB PY 2010 VL 45 IS 3 BP 652 EP 661 DI 10.1007/s10853-009-3979-5 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 536GU UT WOS:000273033700011 ER PT J AU Lugo-Roman, LA Rico, PJ Sturdivant, R Burks, R Settle, TL AF Lugo-Roman, L. A. Rico, P. J. Sturdivant, R. Burks, R. Settle, T. L. TI Effects of serial anesthesia using ketamine or ketamine/medetomidine on hematology and serum biochemistry values in rhesus macaques (Macaca Mulatta) SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE cumulative; non-human primate; parameters; sedation-interaction; washout-combination ID MONKEYS; HYDROCHLORIDE; MEDETOMIDINE; STRESS AB Background This study aimed at determining the cumulative effect of daily anesthesia, using two drug regimens, over hematological and biochemical parameters. Methods Blood samples were obtained from rhesus monkeys 20 minutes after intramuscular administration of ketamine or ketamine/medetomidine combination for three consecutive days and results were evaluated to determine their effect on hematological and serum biochemistry values. Statistical significance of drug, day, and interaction of these two variables were evaluated. Results Drug effect resulted in a dramatic increase of aspartate aminotransferase and creatine kinase values. Day effect resulted in decreases of RBC, HCT, Hgb, and alkaline phosphatase but an increase of other biochemical parameters evaluated. The drug/day interaction effect was found to be -significant for RBC, platelets, aspartate aminotransferase, alanine aminotransferase, and creatine kinase values. Conclusion The results of our study suggest a cumulative effect of serial anesthesia and should be an important consideration when interpreting hematology and serum biochemistry in rhesus macaques. C1 [Lugo-Roman, L. A.] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD 20910 USA. [Rico, P. J.] Uniformed Serv Univ Hlth Sci, Ctr Lab Anim Med, Bethesda, MD 20814 USA. [Sturdivant, R.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Burks, R.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Settle, T. L.] Walter Reed Army Inst Res, Dept Anim Resources, Silver Spring, MD 20910 USA. RP Lugo-Roman, LA (reprint author), Walter Reed Army Inst Res, Div Vet Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM luislugo@ln.amedd.army.mil RI Burks, Robert/J-2481-2015 OI Burks, Robert/0000-0001-6443-6653 NR 17 TC 12 Z9 12 U1 2 U2 9 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD FEB PY 2010 VL 39 IS 1 BP 41 EP 49 DI 10.1111/j.1600-0684.2009.00394.x PG 9 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 540DV UT WOS:000273312000005 PM 19878432 ER PT J AU Settle, TL Rico, PJ Lugo-Roman, LA AF Settle, T. L. Rico, P. J. Lugo-Roman, L. A. TI The effect of daily repeated sedation using ketamine or ketamine combined with medetomidine on physiology and anesthetic characteristics in Rhesus Macaques SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE drug tolerance; heart rate; monkey; non-human primate; phencyclidine; righting reflex; Sedation; alpha(2)-adrenoceptor agonist ID MONKEY MACACA-MULATTA; COMBINATION; HYDROCHLORIDE; XYLAZINE; IMMOBILIZATION; METABOLISM; RATS AB Background Non-human primates are frequently sedated to permit handling that can alter physiological values. The purpose of this study was to identify the effects of daily serial sedation using ketamine (K) or ketamine combined with medetomidine (KM). We hypothesized KM would reduce observed effects of repeated sedation. Methods Eight rhesus macaques were anesthetized for three consecutive days. Physiological data were recorded daily at 5-minute intervals. Time intervals from injection to ataxia, recumbency, first movement and recovery were recorded. Depth of anesthesia was evaluated. Results Data showed an 11.7% increased heart rate at 5 minutes between the first and third day of injection with K and 17.9% with KM. Time from injection to ataxia increased 13.7% with K and 14.3% with KM. Time to recumbency increased 34.7% with K and 37.1% with KM. Conclusion These findings demonstrate repeated anesthesia with ketamine can initiate changes suggesting a tolerance effect. C1 [Settle, T. L.; Rico, P. J.] Uniformed Serv Univ Hlth Sci, Ctr Lab Anim Med, Bethesda, MD 20814 USA. [Settle, T. L.] Walter Reed Army Inst Res, Dept Anim Resources, Silver Spring, MD USA. [Lugo-Roman, L. A.] Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. RP Settle, TL (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Lab Anim Med, 4301 Johnes Bridge Rd, Bethesda, MD 20814 USA. EM timothy.settle1@us.army.mil FU US Army Laboratory Animal Medicine Residency FX The authors would like to express gratitude for the exceptional technical assistance from Kimberly Wilcox, Deborah Rush and Dawn Wolf, and all the staff at Department of Animal Resources, WRAIR/NMRC Division of Veterinary Medicine. We are grateful for the mentorship and guidance of Kelvin Buchanan and Kenneth Jacobsen. Additionally, the authors would like to thank Rod Sturdivant and Rob Burks, who preformed the statistical analysis for this study. This research was supported by funding from the US Army Laboratory Animal Medicine Residency. The content presented in this article has been reviewed by Walter Reed Army Institute of Research. There is no objection to its presentation or publication. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official or reflecting any views of the WRAIR/NMRC, the Department of the Army, or the Department of Defense. NR 19 TC 4 Z9 4 U1 1 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0047-2565 EI 1600-0684 J9 J MED PRIMATOL JI J. Med. Primatol. PD FEB PY 2010 VL 39 IS 1 BP 50 EP 57 DI 10.1111/j.1600-0684.2009.00393.x PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 540DV UT WOS:000273312000006 PM 19912466 ER PT J AU Mc Gann, P Rozak, DA Nikolich, MP Bowden, RA Lindler, LE Wolcott, MJ Lathigra, R AF Mc Gann, Patrick Rozak, David A. Nikolich, Mikejon P. Bowden, Robert A. Lindler, Luther E. Wolcott, Mark J. Lathigra, Raju TI A novel brain heart infusion broth supports the study of common Francisella tularensis serotypes SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Chamberlains; Cultivation; Francisella; Growth characteristics; novicida ID CHEMICALLY DEFINED MEDIUM; PASTEURELLA-TULARENSIS; TULAREMIA VACCINE; MOLECULAR ANALYSIS; SUBSP-TULARENSIS; UNITED-STATES; GROWTH; STRAINS; MEDIA; TEMPERATURE AB Francisella tularensis Schu S4, LVS and U112 have become model organisms for the study of Francisella pathogenesis, and represent a cross section of the different F tularensis subspecies. Both Schu S4 and LVS are fastidious organisms, requiring medium fortified with supplements and nutrients for enhanced growth. Chamberlains defined medium, Tryptone Soy Broth supplemented with cysteine (TSBc), and cation-adjusted Mueller-Hinton broth (CAMHB) supplemented with 2% IsoVitaleX are typically used in the cultivation of these bacteria. In this report, we describe a simple brain heart infusion broth formulation that can be used to obtain superior growth characteristics in all of these model organisms, and can support bacterial growth from low inoculum. Surprisingly, CAMHB, which is favored in the literature for culturing Schu S4 and LVS, induced the worst growth characteristics of the four formulations studied. To expand on these observations, an additional seven strains of F. tularensis, representing types A.I, A.II, and B were selected from the Department of Defense United Culture Collection (UCC) and a comparative analysis of their growth characteristics performed in the four broth formulations. Results demonstrate differences in the growth characteristics of Francisella species that are significantly influenced by both strain type and the choice of growth medium. Though four of the five additional Type A strains displayed superior growth characteristics in Chamberlain's defined medium, growth characteristics of all three model organisms, as well the Type B strains, were enhanced by the new BHI-based broth formulation. We conclude that this medium represents the optimal choice for cultivation of the three model organisms used for Francisella research. (C) 2009 Published by Elsevier B.V. C1 [Lathigra, Raju] Walter Reed Army Inst Res, Dept Biol Def Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. [Rozak, David A.] USA, Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Lindler, Luther E.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD 20910 USA. [Wolcott, Mark J.] USA, Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Lathigra, R (reprint author), Walter Reed Army Inst Res, Dept Biol Def Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. EM raju.lathigra@amedd.army.mil FU Defense Threat Reduction Agency [TMT10049_09_RD_T]; Office of the Assistant Secretary of the Army. (Acquisition, Logistics and Technology); Department of Defense United Culture Collection (UCC) FX Material has been reviewed by the Walter Reed Army Institute of Research and United States Army Medical Research Institute of Infectious Diseases. There is no objection to its presentation. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official, or reflecting the views of the Department of the Army, Department of Defense or the Department of Homeland Security. This work was supported in part by the Defense Threat Reduction Agency under research grant TMT10049_09_RD_T, and the Congressional In-house Laboratory Independent Research Program through the Office of the Assistant Secretary of the Army. (Acquisition, Logistics and Technology). Cultures or materials used in this study were derived in whole or in part from the Department of Defense United Culture Collection (UCC) as maintained in part under the joint Program Executive Office-Chemical and Biological Defense, Medical Identification & Treatment Systems, Critical Reagents Program (JPEO-CBD, CBMS, MITS, CRP). NR 42 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD FEB PY 2010 VL 80 IS 2 BP 164 EP 171 DI 10.1016/j.mimet.2009.12.005 PG 8 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 562EL UT WOS:000275032300009 PM 20005265 ER PT J AU Waits, CM McCarthy, M Ghodssi, R AF Waits, Christopher Mike McCarthy, Matthew Ghodssi, Reza TI A Microfabricated Spiral-Groove Turbopump Supported on Microball Bearings SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS LA English DT Article DE Microelectromechanical systems (MEMS) bearings; micropumps; microturbines; power MEMS; turbopump ID ROLLING FRICTION; MICROPUMPS AB The development of a microfabricated turbopump that is capable of delivering liquid fuel with the flow rates and pressures required for portable power generation is reported. The device is composed of a spiral-groove viscous pump driven by a radial in-flow microturbine and supported using a newly developed encapsulated microball bearing. A planar-contact bearing raceway is employed using 285-mu m-diameter 440C stainless steel microballs. A modification to the raceway geometry, as compared to previous designs, has enabled repeatable operation of the microturbine at speeds up to 87 000 r/min, showing negligible variations in performance for over 6 h and 3.8 million revolutions. Pumping has been demonstrated with water as the working fluid for flow rates of 10-80 mL/h and pressures rises of up to 8.2 kPa. This is the first application to incorporate an encapsulated microball bearing support mechanism, to achieve rotational speeds in excess of 50 000 r/min using a contact bearing, and to demonstrate reliable operation of more than 1 million revolutions. [2009-0123] C1 [Waits, Christopher Mike] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. [McCarthy, Matthew] MIT, Dept Mech Engn, Cambridge, MA 02139 USA. [Ghodssi, Reza] Univ Maryland, Syst Res Inst, MEMS Sensors & Actuators Lab, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Waits, CM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM cwaits@arl.army.mil FU U.S. Army Research Laboratory [W911NF0520026] FX This work was supported in part by the Sensors and Electron Devices Directorate, U.S. Army Research Laboratory, under the Cooperative Agreement W911NF0520026. NR 26 TC 10 Z9 10 U1 1 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1057-7157 EI 1941-0158 J9 J MICROELECTROMECH S JI J. Microelectromech. Syst. PD FEB PY 2010 VL 19 IS 1 BP 99 EP 109 DI 10.1109/JMEMS.2009.2035525 PG 11 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Instruments & Instrumentation; Physics, Applied SC Engineering; Science & Technology - Other Topics; Instruments & Instrumentation; Physics GA 551MM UT WOS:000274213700010 ER PT J AU Hong, HP Thomas, D Waynick, A Yu, WH Smith, P Roy, W AF Hong, Haiping Thomas, Dustin Waynick, Andy Yu, Wenhua Smith, Pauline Roy, Walter TI Carbon nanotube grease with enhanced thermal and electrical conductivities SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Article DE Grease; Carbon nanotube; Thermal conductivity; Electrical conductivity; Synthesis ID SYSTEMS AB A stable and homogeneous grease based on carbon nanotubes (CNTs, single-wall and multiwall) in polyalphaolefin oil has been produced without using a chemical surfactant. For example, for a 11 wt% (7 vol%) single-wall CNT (diameter 1 2 nm, length 0.5-40 lm) loading, the thermal conductivity (TC) of the grease shows a 60-70% increase compared to that for no nanotube loading. In addition, the grease is electrically conductive, has a high dropping point, good temperature resistance, and does not react with copper at temperatures up to 177 degrees C. The performance of carbon nanotube grease could be much better with the improvement of nanotube quality and purity. A possible explanation for these results is that of a high loading of CNTs ([10 wt%), they become associated with each other by van der Waals forces in the grease to form three-dimensional percolation networks. Time-dependent magnetic results demonstrate that, even under the influence of a strong outside magnetic field, the TC value remains constant. This phenomenon can be attributed to the existence of networks that makes magnetic alignment of nanotubes impossible. C1 [Hong, Haiping; Thomas, Dustin] S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. [Waynick, Andy] NCH Corp, Lubricant & Grease Lab, Irving, TX 75062 USA. [Yu, Wenhua] Argonne Natl Lab, Div Energy Syst, Argonne, IL 60439 USA. [Smith, Pauline; Roy, Walter] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hong, HP (reprint author), S Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA. EM Haiping.Hong@sdsmt.edu FU Army Research Lab [DAAD19-02-2-0011] FX H. Hong would like to thank Army Research Lab (Cooperative agreement DAAD19-02-2-0011) for the financial support, and Jesse Wensel and Brian Wright for the thermal conductivity measurements of several grease samples. NR 13 TC 15 Z9 15 U1 1 U2 26 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 J9 J NANOPART RES JI J. Nanopart. Res. PD FEB PY 2010 VL 12 IS 2 SI SI BP 529 EP 535 DI 10.1007/s11051-009-9803-y PG 7 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 565TW UT WOS:000275318700016 ER PT J AU Pumpradit, W Ananworanich, J Lolak, S Shikuma, C Paul, R Siangphoe, U Chaoniti, N Kaew-On, P Paris, R Ruxrungtham, K Valcour, V AF Pumpradit, Wadchara Ananworanich, Jintanat Lolak, Sermsak Shikuma, Cecilia Paul, Robert Siangphoe, Umaporn Chaoniti, Nithima Kaew-On, Peeraporn Paris, Robert Ruxrungtham, Kiat Valcour, Victor CA SE Asia Res Collaboration Hawaii S TI Neurocognitive impairment and psychiatric comorbidity in well-controlled human immunodeficiency virus-infected Thais from the 2NN Cohort Study SO JOURNAL OF NEUROVIROLOGY LA English DT Article DE cognition; dementia; HIV; HAART ID ACTIVE ANTIRETROVIRAL THERAPY; SUB-SAHARAN AFRICA; COGNITIVE IMPAIRMENT; HIV-INFECTION; RISK-FACTORS; INDIVIDUALS; PREVALENCE; DEMENTIA; HAART; DEPRESSION AB This research is a cross-sectional study to determine the frequency of neurocognitive impairment and psychiatric comorbidity among Thais maintained on highly active antiretroviral therapy (HAART) with undetectable plasma human immunodeficiency virus (HIV) RNA in the 2NN Cohort. Sixty-four subjects were evaluated with neurological examinations, neuropsychological testing, and psychiatric questionnaires. Twenty-four subjects (37.5%) were found to have neurocognitive impairment, with 13 (20.3%), 10 (15.6%), and 1 (1.6%) classified as asymptomatic neurocognitive disorder (ANI), mild neurocognitive disorder (MND), and HIV-associated dementia (HAD), respectively. Three subjects (4.7%) had depression and no cases had significant symptoms of anxiety. A notable proportion of well-controlled individuals exhibited neurocognitive impairment. Anxiety and depression were uncommon. 0.05) in their timing. The maximum difference among the hand timers on any given trial was 0.19 +/- 0.14 seconds, with a 95% confidence interval (CI) of -0.08 to 0.41 seconds. Hand timing (4.85 +/- 0.28 seconds) was significantly faster (p < 0.001) than electronic timing (5.16 +/- 0.28 seconds), producing an average difference of 0.31 +/- 0.07 seconds (6.0 +/- 1.3%) and a 95% Cl on the average difference of -0.44 to -0.18 seconds. The correlation between electronic timing and hand timing was ICC = 0.985 (p < 0.001). Practically speaking, electronic timing produces the best measurement of 40-yd dash speed, and using the hand timing produces consistently but significantly faster times. C1 [Mayhew, Jerry L.; Briney, Ben B.; Williams, Tyler B.] Truman State Univ, Human Performance Lab, Kirksville, MO USA. [Mayhew, Jerry L.] AT Still Univ Hlth Sci, Dept Physiol, Kirksville, MO USA. [Houser, Jeremy J.; Piper, Fontaine C.] Truman State Univ, Motor Control Lab, Kirksville, MO USA. [Piper, Fontaine C.] AT Still Univ Hlth Sci, Dept Anat, Kirksville, MO USA. [Brechue, William F.] US Mil Acad, Ctr Phys Dev Excellence, Dept Phys Educ, West Point, NY 10996 USA. RP Mayhew, JL (reprint author), Truman State Univ, Human Performance Lab, Kirksville, MO USA. EM jmayhew@truman.edu NR 18 TC 11 Z9 11 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1064-8011 J9 J STRENGTH COND RES JI J. Strength Cond. Res. PD FEB PY 2010 VL 24 IS 2 BP 447 EP 451 DI 10.1519/JSC.0b013e3181c08860 PG 5 WC Sport Sciences SC Sport Sciences GA 553FA UT WOS:000274350300022 PM 20072055 ER PT J AU Patil, R Clifton, GT Holmes, JP Amin, A Carmichael, MG Gates, JD Benavides, LH Hueman, MT Ponniah, S Peoples, GE AF Patil, Ritesh Clifton, Guy T. Holmes, Jarrod P. Amin, Asna Carmichael, Mark G. Gates, Jeremy D. Benavides, Linda H. Hueman, Matthew T. Ponniah, Sathibalan Peoples, George E. TI Clinical and Immunologic Responses of HLA-A3(+) Breast Cancer Patients Vaccinated with the HER2/neu-Derived Peptide Vaccine, E75, in a Phase I/II Clinical Trial SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID CYTOTOXIC T-LYMPHOCYTES; MHC CLASS-I; OVARIAN-CANCER; HEPATOCELLULAR-CARCINOMA; PROGNOSTIC-FACTORS; METASTATIC BREAST; HER-2/NEU; ANTIGEN; IDENTIFICATION; HLA AB BACKGROUND: We have treated disease-free breast cancer patients with an HER2/neu-derived peptide, E75, as an adjuvant vaccine. E75 was originally described as HLA-A2-restricted and has been previously tested in this population. Based on computer modeling, E75 is predicted to bind to HLA-A3, and preclinical data support this. We conducted a clinical trial of E75 in HLA-A3(+), A2(-) (A3) patients. STUDY DESIGN: Disease-free breast cancer patients were enrolled after standard therapy in phase I/II trials. M patients were enrolled in parallel with A2 patients and vaccinated with E75 and granulocyte-macrophage colony-stimulating factor immunoadjuvant. A2(-), A3(-) patients were followed as controls. Toxicities were graded. Immunologic responses were assessed by delayed-type hypersensitivity reactions and E75-specific interferon-gamma enzyme-linked immunosorbent spot assay. Clinical recurrences were documented. RESULTS: Thirteen A3 patients completed the vaccine schedule. Clinicopathologic features were similar between A3, A2, and control patients, except for more HER2/neu-overexpressing tumors in the A2 group and more estrogen-receptor/progesterone-receptor-negative tumors in A2 and A3 groups. Toxicity profiles and postvaccination delayed-type hypersensitivity were similar in A3 and A2 patients. Enzyme-linked immunosorbent spot assay results varied, but A3 patients' median spots increased pre- to postvaccination (p = 0.2). Recurrences were lower in the A3 group (7.7%) at 30-month median follow-up compared with published recurrence in A2-vaccinated (8.3%) and control groups (14.8%) at 26-month median follow-up. CONCLUSIONS: HLA restriction limits potential use of peptide-based cancer vaccines. This trial demonstrates that HLA-A3 patients respond similarly to E75 vaccination as HLA-A2 patients, suggesting the potential use of the E75 vaccine in up to 76% of the population. (J Am Coll Surg 2010;210: 140-147. Published by Elsevier Inc. on behalf of the American College of Surgeons) C1 [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Patil, Ritesh] Windber Med Ctr, Joyce Murtha Breast Care Ctr, Windber, PA USA. [Holmes, Jarrod P.] USN, Dept Hematol & Med Oncol, Med Ctr, San Diego, CA 92152 USA. [Amin, Asna; Carmichael, Mark G.; Hueman, Matthew T.; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Program, US Mil Canc Inst,Dept Surg, Bethesda, MD 20814 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil FU United States Military Cancer Institute; Department of Surgery; Uniformed Services University of the Health Sciences; Department of Clinical Investigation, Walter Reed Army Medical Center, Bethesda, MD FX This study was supported by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, and the Department of Clinical Investigation, Walter Reed Army Medical Center, Bethesda, MD. NR 40 TC 16 Z9 16 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD FEB PY 2010 VL 210 IS 2 BP 140 EP 147 DI 10.1016/j.jamcollsurg.2009.10.022 PG 8 WC Surgery SC Surgery GA 617KP UT WOS:000279279900002 PM 20113933 ER PT J AU Veljkovic, R Protic, M Gluhovic, A Potic, Z Milosevic, Z Stojadinovic, A AF Veljkovic, Radovan Protic, Mladjan Gluhovic, Aleksandar Potic, Zoran Milosevic, Zoran Stojadinovic, Alexander TI Prospective Clinical Trial of Factors Predicting the Early Development of Incisional Hernia after Midline Laparotomy SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Article ID ABDOMINAL INCISIONS; CLOSURE; METAANALYSIS; SURGERY AB BACKGROUND: Information-based scoring systems predictive of outcomes of midline laparotomy are needed; these systems can support surgical decisions with the aim of improving patient outcomes and quality of life, and reducing the risk of secondary surgical procedures. STUDY DESIGN: All study subjects were followed for a minimum of 6 months after operation. Numerous demographic, clinical, treatment, and outcomes-related perioperative factors were recorded to determine statistical association with the primary end point: incisional hernia development. The first analysis was designed to establish the statistical model (scoring system) for estimating the risk of incisional hernia within 6 months of midline laparotomy. Univariate and multivariate analyses were performed. A simple additive model was constructed using stepwise logistic and linear regression. The second part of the study analysis was validation of the scoring systems developed initially. RESULTS: A logistic linear minimum regression model was developed based on four covariates independently predictive of incisional hernia: Body mass index (BMI) > 24.4kg/m(2); fascia] suture to incision ratio (SIR) < 4.2; deep surgical site, deep space, or organ infection (SSI); and time to suture removal or complete epithelialization > 16 days (TIME). The hernia risk scoring system equation [p(%) = 32(SIR) + 30(SSI) + 9(TIME) + 2(BMI)1 provided accurate estimates of incisional hernia according to stratified risk groups based on total score: low (0 to 5 points), 1.0%; moderate (6 to 15 points), 9.7%; increased (16 to 50 points), 30.2%; and markedly increased (> 50 points), 73.1%. CONCLUSIONS: A statistically valid, straightforward, and clinically useful predictive model was developed for estimating the risk of incisional hernia within 6 months of midline laparotomy. Prospective independent validation of this model appears indicated. (J Am Coll Surg 2010;210:210-219. Published by Elsevier Inc. on behalf of the American College of Surgeons) C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, US Mil Canc Inst, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Veljkovic, Radovan; Protic, Mladjan; Gluhovic, Aleksandar; Milosevic, Zoran] Clin Abdominal Endocrine & Transplantat Surg, Clin Ctr Vojvodina, Novi Sad, Serbia. [Protic, Mladjan] Potic Consulting, Agcy Consulting & Management, Novi Sad, Serbia. [Stojadinovic, Alexander] US Mil Canc Inst, Clin Trials Grp, Washington, DC USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, US Mil Canc Inst, Dept Surg, Div Surg Oncol, 6900 Georgia Ave,Room 5C27A NW, Washington, DC 20307 USA. NR 11 TC 46 Z9 47 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD FEB PY 2010 VL 210 IS 2 BP 210 EP 219 DI 10.1016/j.jamcollsurg.2009.10.013 PG 10 WC Surgery SC Surgery GA 617KP UT WOS:000279279900011 PM 20113942 ER PT J AU Smith, TJ Sigrist, LD Bathalon, GP McGraw, S Karl, JP Young, AJ AF Smith, Tracey J. Sigrist, Lori D. Bathalon, Gaston P. McGraw, Susan Karl, J. Philip Young, Andrew J. TI Efficacy of a Meal-Replacement Program for Promoting Blood Lipid Changes and Weight and Body Fat Loss in US Army Soldiers SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article ID RISK-FACTORS; OBESITY; INTERVENTION; OVERWEIGHT; INJURIES; ADULTS; WOMEN AB Excess weight is associated with negative health outcomes. Meal replacements are effective in promoting favorable body composition changes in civilian populations; however, their efficacy with military service members who have unique lifestyles is unknown. The objective of this randomized controlled trial was to determine the efficacy of the Army's education-based weight-management program, "Weigh to Stay," with and without meal replacements for improving blood lipids, and to promote weight and body fat loss in overweight US Army soldiers. Soldiers (n=113; 76 males/37 females) attending Weigh to Stay at Fort Bragg, NC, in 2006/2007 were randomized to Weigh to Stay only or a commercially available meal-replacement program (two meal replacements per day) in conjunction with Weigh to Stay, and followed until Army body fat standards were met or for 6 months if standards were not met. Study completers (n=46) in both treatment groups lost weight (Weigh to Stay: -2.7 +/- 4.3 kg; meal replacers: -3.8 +/- 3.5 kg) and fat mass (Weigh to Stay, -2.7 +/- 3.2 kg; meal replacers: -2.9 +/- 2.5 kg), and improved high-density lipoprotein cholesterol concentrations (Weigh to Stay: 13 +/- 9 mg/dL [0.34 +/- 0.23 mmol/L]; meal replacers: 8 +/- 7 mg/dL [0.21 +/- 0.18 mmol/L]; P<0.05); however, no between-group differences were observed. Attrition was lower (P=0.009) and success in meeting body fat standards tended to be higher (P=0.06) for the meal replacers vs Weigh to Stay participants. Intent-to-treat analysis demonstrated that meal replacers lost more weight (1.2 +/- 0.5 kg), percent body fat (1.0%+/- 0.4%), and fat mass (0.8 +/- 0.4 kg) compared to Weigh to Stay volunteers (P<0.05). Our findings suggest that meal replacement use can be recommended as a potential adjunct strategy to Weigh to Stay. J Am Diet Assoc. 2010;110:268-273. C1 [Smith, Tracey J.; Sigrist, Lori D.] USA, Environm Med Res Inst, Mil Nutr Div, Weight Management Program, Natick, MA 01760 USA. [Sigrist, Lori D.] Grad Program Nutr, Ft Sam Houston, TX USA. RP Smith, TJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Weight Management Program, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Tracey.j.smith@us.army.mu OI Karl, J. Philip/0000-0002-5871-2241 NR 25 TC 9 Z9 9 U1 0 U2 4 PU AMER DIETETIC ASSOC PI CHICAGO PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD FEB PY 2010 VL 110 IS 2 BP 268 EP 273 DI 10.1016/j.jada.2009.10.039 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 587LK UT WOS:000276993700017 PM 20102855 ER PT J AU McGlasson, DL Romick, BG Rubal, BJ AF McGlasson, D. L. Romick, B. G. Rubal, B. J. TI Comparison of a Chromogenic Factor X Assay With International Normalized Ratio for Monitoring Oral Anticoagulation Therapy SO JOURNAL OF THROMBOSIS AND THROMBOLYSIS LA English DT Meeting Abstract C1 [McGlasson, D. L.; Romick, B. G.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. [Rubal, B. J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5305 J9 J THROMB THROMBOLYS JI J. Thromb. Thrombolysis PD FEB PY 2010 VL 29 IS 2 BP 255 EP 255 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 550AJ UT WOS:000274097500045 ER PT J AU Kheirabadi, BS Mace, JE Terrazas, IB Fedyk, CG Estep, JS Dubick, MA Blackbourne, LH AF Kheirabadi, Bijan S. Mace, James E. Terrazas, Irasema B. Fedyk, Chriselda G. Estep, J. Scot Dubick, Michael A. Blackbourne, Lorne H. TI Safety Evaluation of New Hemostatic Agents, Smectite Granules, and Kaolin-Coated Gauze in a Vascular Injury Wound Model in Swine SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE WoundStat; Combat gauze; Hemorrhage control; Hemostatic agent; Vascular injury; Animal model; Swine ID EXTREMITY ARTERIAL HEMORRHAGE; QUIKCLOT; DRESSINGS; CULTURES AB Background: In 2007, a potent procoagulant mineral called WoundStat (WS), consisting of smectite granules, received clearance from the Food and Drug Administration for marketing in the United States for temporary treatment of external hemorrhage. Previously, we found that microscopic WS particles remained in the injured vessels that were treated, despite seemingly adequate wound debridement. Thus, we investigated the thromboembolic risk of using WS when compared with kaolin-coated gauze, Combat Gauze (CG); or regular gauze, Kerlix (KX) to treat in external wound with vascular injuries in pigs. Methods: The right common carotid artery and external jugular vein of pigs were isolated and sharply transected (50%). After 30 seconds of free bleeding, the neck wounds were packed with WS, CG, or KX and compressed until hemostasis was achieved (n = 8 per group). Wounds were debrided after 2 hours. and vascular injuries were primarily repaired with suture. Blood flow was restored after infusing 1 L of crystalloid (no heparin or aspirin) and the wounds were closed. Two hours later, computed tomographic angiography was performed, and the Wounds were reopened to harvest the vessels. The brains and lungs were recovered for gross and microscopic examination after euthanasia. Results: No differences were found in baseline measurements. Thrombelastography showed similar hypercoagulability of the final blood samples when compared with baselines in all groups. All vessels treated with KX or CG were patent and had no thrombus or blood clot in their lumen. In contrast, seven of eight carotid arteries and six of eight jugular veins treated with WS developed large occlusive red thrombi and had no flow, Small clots and WS residues were also found in the lungs of two pigs. Histologically significant endothelial and transmural damage was seen in WS-treated vessels with luminal thrombi and embedded WS residues. Conclusion: WS granules caused endothelial injury and significant transmural damage to the vessels that render them nonviable for primary surgical repair. The granules can enter systemic circulation and cause distal thrombosis in vital organs. More relevant in vitro and in vivo safety tests should be required for clearance of new hemostatic agents. C1 [Kheirabadi, Bijan S.; Mace, James E.; Terrazas, Irasema B.; Fedyk, Chriselda G.; Estep, J. Scot; Dubick, Michael A.; Blackbourne, Lorne H.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@us.army.mil FU US Army Medical Research and Materiel Command; Veterinary Support Division FX Supported by the US Army Medical Research and Materiel Command.; We thank the staff of our Veterinary Support Division for their support and assistance in conducting these experiments. NR 20 TC 61 Z9 64 U1 3 U2 17 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD FEB PY 2010 VL 68 IS 2 BP 269 EP 277 DI 10.1097/TA.0b013e3181c97ef1 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 555FC UT WOS:000274492600005 PM 20154537 ER PT J AU Vasterling, JJ Proctor, SP Friedman, MJ Hoge, CW Heeren, T King, LA King, DW AF Vasterling, Jennifer J. Proctor, Susan P. Friedman, Matthew J. Hoge, Charles W. Heeren, Timothy King, Lynda A. King, Daniel W. TI PTSD Symptom Increases in Iraq-Deployed Soldiers: Comparison With Nondeployed Soldiers and Associations With Baseline Symptoms, Deployment Experiences, and Postdeployment Stress SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID MENTAL-HEALTH PROBLEMS; GULF-WAR VETERANS; UK ARMED-FORCES; POSTTRAUMATIC-STRESS; RISK-FACTORS; MILITARY PERSONNEL; DISORDER; COMBAT; POPULATION; CHECKLIST AB This prospective study examined: (a) the effects of Iraq war deployment versus non-deployment on pre- to postdeployment change in PTSD symptoms and (b) among deployed soldiers, associations of deployment/postdeployment stress exposures and baseline PTSD symptoms with PTSD symptom change. Seven hundred seventy-four U.S. Army soldiers completed self-report measures of stress exposure and PTSD symptom severity before and after Iraq deployment and were compared with 309 soldiers who did not deploy. Deployed soldiers, compared with non-deployed soldiers, reported increased PTSD symptom severity from Time 1 to Time 2. After controlling for baseline symptoms, deployment-related stressors contributed to longitudinal increases in PTSD symptoms. Combat severity was more strongly associated with symptom increases among active duty soldiers with higher baseline PTSD symptoms. C1 [Vasterling, Jennifer J.; Proctor, Susan P.; King, Lynda A.; King, Daniel W.] VA Boston Healthcare Syst, VA Natl Ctr PTSD, Boston, MA 02130 USA. [Vasterling, Jennifer J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA. [Proctor, Susan P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. [Friedman, Matthew J.] VA Natl Ctr PTSD, White River Jct, VT USA. [Friedman, Matthew J.] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Psychiat, Hanover, NH 03756 USA. [Friedman, Matthew J.] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pharmacol, Hanover, NH 03756 USA. [Hoge, Charles W.] USA, Med Res & Mat Command, Dept Psychiat & Behav Sci, Walter Reed Army Inst Res, Silver Spring, MD USA. [Heeren, Timothy] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA. [King, Lynda A.; King, Daniel W.] Boston Univ, Dept Psychol, Boston, MA 02215 USA. RP Vasterling, JJ (reprint author), VA Boston Healthcare Syst, VA Natl Ctr PTSD, 150 S Huntington Ave, Boston, MA 02130 USA. EM jennifer.vasterling@va.gov NR 34 TC 107 Z9 107 U1 1 U2 19 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD FEB PY 2010 VL 23 IS 1 BP 41 EP 51 DI 10.1002/jts.20487 PG 11 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 571FW UT WOS:000275738100007 PM 20135698 ER PT J AU Cozza, SJ Guimond, JM McKibben, JBA Chun, RS Arata-Maiers, TL Schneider, B Maiers, A Fullerton, CS Ursano, RJ AF Cozza, Stephen J. Guimond, Jennifer M. McKibben, Jodi B. A. Chun, Ryo S. Arata-Maiers, Teresa L. Schneider, Brett Maiers, Alan Fullerton, Carol S. Ursano, Robert J. TI Combat-Injured Service Members and Their Families: The Relationship of Child Distress and Spouse-Perceived Family Distress and Disruption SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID PARENTS; STRESS AB Combat injury in military service members affects both child and family functioning. This preliminary study examined the relationship of child distress postinjury to preinjury deployment-related family distress, injury severity, and family disruption postinjury. Child distress postinjury was assessed by reports from 41 spouses of combat- injured service members who had been hospitalized at two military tertiary care treatment centers. Families with high preinjury deployment-related family distress and high family disruption postinjury were more likely to report high child distress postinjury. Spouse-reported injury severity was unrelated to child distress. Findings suggest that early identification and intervention with combat-injured families experiencing distress and disruption may be warranted to support family and child health, regardless of injury severity. C1 [Cozza, Stephen J.; Guimond, Jennifer M.; McKibben, Jodi B. A.; Fullerton, Carol S.; Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, Bethesda, MD 20817 USA. [Chun, Ryo S.; Schneider, Brett] Walter Reed Army Med Ctr, Child & Adolescent Psychiat Serv, Washington, DC 20307 USA. [Arata-Maiers, Teresa L.; Maiers, Alan] San Antonio Mil Med Ctr, Warrior Resiliency Program, San Antonio, TX USA. RP Cozza, SJ (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, 6700A Rockledge Dr, Bethesda, MD 20817 USA. EM scozza@usuhs.mil RI McKibben, Jodi/H-5973-2011; OI Guimond, Jennifer/0000-0002-8887-5885 NR 10 TC 35 Z9 35 U1 6 U2 10 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD FEB PY 2010 VL 23 IS 1 BP 112 EP 115 DI 10.1002/jts.20488 PG 4 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 571FW UT WOS:000275738100016 PM 20146393 ER PT J AU Ray, N Whidby, J Stewart, S Hooper, JW Bertolotti-Ciarlet, A AF Ray, Neelanjana Whidby, Jillian Stewart, Shaun Hooper, Jay W. Bertolotti-Ciarlet, Andrea TI Study of Andes virus entry and neutralization using a pseudovirion system SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Andes virus; Pseudovirion; Cell entry; Neutralization ID HANTAVIRUS PULMONARY SYNDROME; VESICULAR STOMATITIS-VIRUS; TO-PERSON TRANSMISSION; M GENOME SEGMENT; HEMORRHAGIC-FEVER; RENAL SYNDROME; HANTAAN VIRUS; CELLULAR ENTRY; ENVELOPE GLYCOPROTEINS; MOLECULAR EVIDENCE AB Andes virus (ANDV), a member of the Hantavirus genus in the family Bunyaviridae, causes an acute disease characteristic of New-World hantaviruses called hantavirus pulmonary syndrome (HPS). HPS is a highly pathogenic disease with a case-fatality rate of 40%. ANDV is the only hantavirus reported to spread directly from human-to-human. The aim of the present study was to develop a quantitative and high-throughput pseudovirion assay to study ANDV infection and neutralization in biosafety level 2 facilities (BSL-2). This pseudovirion assay is based on incorporation of ANDV glycoproteins onto replication-defective vesicular stomatitis virus (VSV) cores in which the gene for the surface G protein has been replaced by that encoding Renilla luciferase. Infection by the pseudovirions can be quantified by luciferase activity of infected cell lysates. ANDV pseudovirions were neutralized by ANDV-specific antisera, and there was good concordance between specificity and neutralization titers of ANDV hamster sera as determined by our pseudovirion assay and a commonly used plaque reduction neutralization titer (PRNT) assay. In addition, the pseudovirions were used to evaluate the requirements for ANDV entry, like pH dependency and the role of beta 3 integrin, the reported receptor for other pathogenic hantaviruses, on entry. (C) 2009 Elsevier B.V. All rights reserved. C1 [Ray, Neelanjana; Whidby, Jillian; Stewart, Shaun; Bertolotti-Ciarlet, Andrea] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. [Hooper, Jay W.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. RP Bertolotti-Ciarlet, A (reprint author), Merck & Co Inc, Merck Res Labs, Sumneytown Pike,POB 4,Mail Stop WP75-300, West Point, PA 19486 USA. EM andrea_bertolotti-ciarlet@merck.com OI Hooper, Jay/0000-0002-4475-0415 FU Military Infectious Disease Research Program, U.S. Army Medical Research and Material Command [T0038_08_RD] FX The authors thank Dr. Robert W. Do ms at the University of Pennsylvania in Philadelphia for providing guidance and reagents for the completion of these studies. Portions of the research described herein were sponsored by the Military Infectious Disease Research Program, U.S. Army Medical Research and Material Command, Project no. T0038_08_RD. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. NR 45 TC 19 Z9 19 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD FEB PY 2010 VL 163 IS 2 BP 416 EP 423 DI 10.1016/j.jviromet.2009.11.004 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 562SJ UT WOS:000275074500038 PM 19903496 ER PT J AU Fine, DL Jenkins, E Martin, SS Glass, P Parker, MD Grimm, B AF Fine, Donald L. Jenkins, Erin Martin, Shannon S. Glass, Pamela Parker, Michael D. Grimm, Brad TI A multisystem approach for development and evaluation of inactivated vaccines for Venezuelan equine encephalitis virus (VEEV) SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Venezuelan equine encephalitis virus (VEEV); Formalin inactivated vaccines; Gamma irradiated vaccines; Neurovirulence; Alphavirus ID EMBRYO CELL CULTURE; ENCEPHALOMYELITIS VIRUS; IMMUNITY; IMMUNOGENICITY; IMMUNIZATION; CANDIDATE; INFECTION; RADIATION; STRAINS; HUMANS AB A multisystem approach was used to assess the efficiency of several methods for inactivation of Venezuelan equine encephalitis virus (VEEV) vaccine candidates. A combination of diverse assays (plaque, in vitro cytopathology and mouse neurovirulence) was used to verify virus inactivation, along with the use of a specific ELISA to measure retention of VEEV envelope glycoprotein epitopes in the development of several inactivated VEEV candidate vaccines derived from an attenuated strain of VEEV (V3526). Incubation of V3526 aliquots at temperatures in excess of 64 degrees C for periods >30 min inactivated the virus, but substantially reduced VEEV specific monoclonal antibody binding of the inactivated material. In contrast, V3526 treated either with formalin at concentrations of 0.1% or 0.5% (v/v) for 4 or 24 h, or irradiated with 50 kGy gamma radiation rendered the virus non-infectious while retaining significant levels of monoclonal antibody binding. Loss of infectivity of both the formalin inactivated (fV3526) and gamma irradiated (gV3526) preparations was confirmed via five successive blind passages on BHK-21 cells. Similarly, loss of neurovirulence for fV3526 and gV3526 was demonstrated via intracerebral inoculation of suckling BALB/c mice. Excellent protection against subcutaneous challenge with VEEV IA/B Trinidad donkey strain was demonstrated using a two dose immunization regimen with either fV3526 or gV3526. The combination of in vitro and in vivo assays provides a practical approach to optimize manufacturing process parameters for development of other inactivated viral vaccines. (C) 2009 Elsevier B.V. All rights reserved. C1 [Fine, Donald L.; Jenkins, Erin; Martin, Shannon S.] A CSC Co, DynPort Vaccine Co LLC DVC, Frederick, MD 21702 USA. [Glass, Pamela; Parker, Michael D.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Grimm, Brad] SAFC Pharma Inc, Carlsbad, CA 92009 USA. RP Fine, DL (reprint author), A CSC Co, DynPort Vaccine Co LLC DVC, 64 Thomas Johnson Dr, Frederick, MD 21702 USA. EM dfine@csc.com RI Glass, Pamela/G-1170-2011 FU National Institute of Allergy and Infectious Diseases [1UC1AI062538-01]; Joint Science and Technology Office-Chemical, Biological Defense [1.1C0041_09_RD_B] FX This work was funded by the National Institute of Allergy and Infectious Diseases, (1UC1AI062538-01) and the Joint Science and Technology Office-Chemical, Biological Defense (Plan 1.1C0041_09_RD_B). NR 37 TC 11 Z9 11 U1 1 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD FEB PY 2010 VL 163 IS 2 BP 424 EP 432 DI 10.1016/j.jviromet.2009.11.006 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 562SJ UT WOS:000275074500039 PM 19903494 ER PT J AU Seaman, MS Janes, H Hawkins, N Grandpre, LE Devoy, C Giri, A Coffey, RT Harris, L Wood, B Daniels, MG Bhattacharya, T Lapedes, A Polonis, VR McCutchan, FE Gilbert, PB Self, SG Korber, BT Montefiori, DC Mascola, JR AF Seaman, Michael S. Janes, Holly Hawkins, Natalie Grandpre, Lauren E. Devoy, Colleen Giri, Ayush Coffey, Rory T. Harris, Linda Wood, Blake Daniels, Marcus G. Bhattacharya, Tanmoy Lapedes, Alan Polonis, Victoria R. McCutchan, Francine E. Gilbert, Peter B. Self, Steve G. Korber, Bette T. Montefiori, David C. Mascola, John R. TI Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; GP120 ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; SUBTYPE-B; TYPE-1; VACCINE; INFECTION; CLADE; IMMUNIZATION; MACAQUES AB The restricted neutralization breadth of vaccine-elicited antibodies is a major limitation of current human immunodeficiency virus-1 (HIV-1) candidate vaccines. In order to permit the efficient identification of vaccines with enhanced capacity for eliciting cross-reactive neutralizing antibodies (NAbs) and to assess the overall breadth and potency of vaccine-elicited NAb reactivity, we assembled a panel of 109 molecularly cloned HIV-1 Env pseudoviruses representing a broad range of genetic and geographic diversity. Viral isolates from all major circulating genetic subtypes were included, as were viruses derived shortly after transmission and during the early and chronic stages of infection. We assembled a panel of genetically diverse HIV-1-positive (HIV-1(+)) plasma pools to assess the neutralization sensitivities of the entire virus panel. When the viruses were rank ordered according to the average sensitivity to neutralization by the HIV-1(+) plasmas, a continuum of average sensitivity was observed. Clustering analysis of the patterns of sensitivity defined four subgroups of viruses: those having very high (tier 1A), above-average (tier 1B), moderate (tier 2), or low (tier 3) sensitivity to antibody-mediated neutralization. We also investigated potential associations between characteristics of the viral isolates (clade, stage of infection, and source of virus) and sensitivity to NAb. In particular, higher levels of NAb activity were observed when the virus and plasma pool were matched in clade. These data provide the first systematic assessment of the overall neutralization sensitivities of a genetically and geographically diverse panel of circulating HIV-1 strains. These reference viruses can facilitate the systematic characterization of NAb responses elicited by candidate vaccine immunogens. C1 [Seaman, Michael S.; Grandpre, Lauren E.; Devoy, Colleen; Giri, Ayush; Coffey, Rory T.] Harvard Univ, Div Viral Pathogenesis, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Janes, Holly; Hawkins, Natalie; Harris, Linda; Wood, Blake; Gilbert, Peter B.; Self, Steve G.] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA. [Daniels, Marcus G.; Bhattacharya, Tanmoy; Lapedes, Alan; Korber, Bette T.] Los Alamos Natl Lab, Los Alamos, NM USA. [Polonis, Victoria R.; McCutchan, Francine E.] Walter Reed Army Inst Res, Rockville, MD USA. [Montefiori, David C.] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA. [Mascola, John R.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. RP Seaman, MS (reprint author), Harvard Univ, Div Viral Pathogenesis, Sch Med, Beth Israel Deaconess Med Ctr, 330 Brookline Ave,CLS-1001, Boston, MA 02215 USA. EM mseaman@bidmc.harvard.edu RI Bhattacharya, Tanmoy/J-8956-2013; OI Bhattacharya, Tanmoy/0000-0002-1060-652X; Korber, Bette/0000-0002-2026-5757 FU Bill & Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery/Comprehensive Antibody Vaccine Immune Monitoring Consortium [38619]; Vaccine Immunology Statistical Center [38744] FX This study was supported by the Bill & Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery/Comprehensive Antibody Vaccine Immune Monitoring Consortium, grant number 38619, and Vaccine Immunology Statistical Center, grant number 38744. NR 47 TC 279 Z9 280 U1 2 U2 6 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD FEB PY 2010 VL 84 IS 3 BP 1439 EP 1452 DI 10.1128/JVI.02108-09 PG 14 WC Virology SC Virology GA 542XC UT WOS:000273531600023 PM 19939925 ER PT J AU Gardner, B Royle, JA Wegan, MT Rainbolt, RE Curtis, PD AF Gardner, Beth Royle, J. Andrew Wegan, Michael T. Rainbolt, Raymond E. Curtis, Paul D. TI Estimating Black Bear Density Using DNA Data From Hair Snares SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article DE abundance; Bayesian analysis; black bears; hair-snare trapping; hierarchical model; Markov chain Monte Carlo (MCMC); spatial capture-recapture ID CAPTURE-RECAPTURE MODELS; MARK-RECAPTURE; GRIZZLY BEARS; POPULATION-SIZE; GENETIC DIVERSITY; URSUS-ARCTOS; HIERARCHICAL MODEL; DATA AUGMENTATION; TIGER DENSITIES; HOME-RANGE AB DNA-based mark-recapture has become a methodological cornerstone of research focused on bear species. The objective of such studies is often to estimate population size; however, doing so is frequently complicated by movement of individual bears. Movement affects the probability of detection and the assumption of closure of the population required in most models. To mitigate the bias caused by movement of individuals, population size and density estimates are often adjusted using ad hoc methods, including buffering the minimum polygon of the trapping array. We used a hierarchical, spatial capture-recapture model that contains explicit components for the spatial-point process that governs the distribution of individuals and their exposure to (via movement), and detection by, traps. We modeled detection probability as a function of each individual's distance to the trap and an indicator variable for previous capture to account for possible behavioral responses. We applied our model to a 2006 hair-snare study of a black bear (Ursus americanus) population in northern New York, USA. Based on the microsatellite marker analysis of collected hair samples, 47 individuals were identified. We estimated mean density at 0.20 bears/km(2). A positive estimate of the indicator variable suggests that bears are attracted to baited sites; therefore, including a trap-dependence covariate is important when using bait to attract individuals. Bayesian analysis of the model was implemented in WinBUGS, and we provide the model specification. The model can be applied to any spatially organized trapping array (hair snares, camera traps, mist nests, etc.) to estimate density and can also account for heterogeneity and covariate information at the trap or individual level. C1 [Gardner, Beth; Royle, J. Andrew] US Geol Survey, Patuxent Wildlife Res Ctr, Laurel, MD 20708 USA. [Wegan, Michael T.; Curtis, Paul D.] Cornell Univ, Dept Nat Resources, Ithaca, NY 14853 USA. [Rainbolt, Raymond E.] USA, Fish & Wildlife Management Program, Ft Drum, NY 13602 USA. RP Gardner, B (reprint author), US Geol Survey, Patuxent Wildlife Res Ctr, Laurel, MD 20708 USA. EM bgardner@usgs.gov OI Royle, Jeffrey/0000-0003-3135-2167 NR 53 TC 56 Z9 56 U1 6 U2 62 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-541X EI 1937-2817 J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD FEB PY 2010 VL 74 IS 2 BP 318 EP 325 DI 10.2193/2009-101 PG 8 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA 551WM UT WOS:000274243800018 ER PT J AU Furusato, B Parker, P Nydam, T Rice, K Srivastava, S Brassell, S McLeod, DG Sesterhenn, IA AF Furusato, B. Parker, P. Nydam, T. Rice, K. Srivastava, S. Brassell, S. McLeod, D. G. Sesterhenn, I. A. TI Extensive Multifocal Prostatic Adenocarcinomas (Greater Than 20) in Radical Prostatectonny Specimens of Young Men SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 99th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 20-26, 2010 CL Washington, DC SP US & Canadian Acad Pathol C1 Armed Forces Inst Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD FEB PY 2010 VL 90 SU 1 MA 849 BP 192A EP 192A PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA 553AR UT WOS:000274337300848 ER PT J AU Furusato, B Ali, A Ts'o, PO Lum, ZP Srivastava, S Brassell, S McLeod, DG Sesterhenn, IA AF Furusato, B. Ali, A. Ts'o, P. O. Lum, Z. P. Srivastava, S. Brassell, S. McLeod, D. G. Sesterhenn, I. A. TI Assessment of Circulating Tumor Cells (CTCs) in Low Tumor Volume Prostate Cancer Patients SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 99th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 20-26, 2010 CL Washington, DC SP US & Canadian Acad Pathol C1 Armed Forces Inst Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. CCC Diagnost LLC, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD FEB PY 2010 VL 90 SU 1 MA 850 BP 192A EP 192A PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA 553AR UT WOS:000274337300849 ER PT J AU Summers, TA Clifton, GT Gates, JD Dobson, L Horkayne-Szakely, I Shaw, JC Nissan, A Sandberg, GD Peoples, GE Stojadinovic, A AF Summers, T. A. Clifton, G. T. Gates, J. D. Dobson, L. Horkayne-Szakely, I. Shaw, J. C. Nissan, A. Sandberg, G. D. Peoples, G. E. Stojadinovic, A. TI Assessment of Immunohistochemical Protein Expression in Tissue Microarrays Using Virtual Microscopic Image Analysis SO LABORATORY INVESTIGATION LA English DT Meeting Abstract CT 99th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 20-26, 2010 CL Washington, DC SP US & Canadian Acac Pathol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Brooke Army Med Ctr, San Antonio, TX USA. SlidelPath, Dublin, Ireland. Armed Forces Inst Pathol, Washington, DC 20306 USA. Hadassah Univ Hosp Mt Scopus, Jerusalem, Israel. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD FEB PY 2010 VL 90 SU 1 MA 1499 BP 336A EP 336A PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA 553AR UT WOS:000274337301514 ER PT J AU Wirtz, ED Bothwell, N Klem, C AF Wirtz, Eric D. Bothwell, Nici Klem, Christopher TI Role of the Otolaryngologist in the Treatment of Struma Ovarii SO LARYNGOSCOPE LA English DT Article DE Struma ovarii; malignant struma ovarii; papillary thyroid carcinoma; follicular variant of malignant papillary struma ovarii ID THYROID-CANCER; FOCUS AB Struma ovarii, a rare germ cell tumor of the ovary composed of >50% thyroid tissue, is traditionally managed by gynecologic surgeons. Although struma ovarii is typically cured by simple excision, otolaryngology-head and neck surgeons may play a critical role in caring for these patients. In this article, we present two cases of struma ovarii and discuss the role of the otolaryngologist. C1 [Wirtz, Eric D.; Klem, Christopher] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. [Bothwell, Nici] Reynolds Army Hosp, Dept Otolaryngol, Ft Still, OK USA. RP Wirtz, ED (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM eric.d.wirtz@us.army.mil NR 7 TC 3 Z9 4 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD FEB PY 2010 VL 120 IS 2 BP 259 EP 260 DI 10.1002/lary.20733 PG 2 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA 556QA UT WOS:000274605000008 PM 20013844 ER PT J AU Boyce, LA Zaccaro, SJ Wisecarver, MZ AF Boyce, Lisa A. Zaccaro, Stephen J. Wisecarver, Michelle Zazanis TI Propensity for self-development of leadership attributes: Understanding, predicting, and supporting performance of leader self-development SO LEADERSHIP QUARTERLY LA English DT Review DE Leadership development; Professional self-development; Motivation and skills; Organizational support ID GOAL ORIENTATION; TRAINING EFFECTIVENESS; ORGANIZATIONAL COMMITMENT; INDIVIDUAL-DIFFERENCES; CAREER MOTIVATION; LEARNING OUTCOMES; FEEDBACK-SEEKING; JOB INVOLVEMENT; MODEL; EFFICACY AB Little systematic research has been reported to advance understanding of the characteristics associated with individuals who initiate self-development activities to grow leadership skills The purpose of the present research was to examine cognitive. dispositional, and motivational precursors to the propensity to engage in leadership self-development. A second purpose was to examine the role of organizational support on the relationships between self-development propensity and reported self-development activities Over 400 junior-military, leaders participated in a three-stage Survey administration designed to test a structural model of leader self-development. Results indicate that a person having individual characteristics related to mastery. work, and career-growth orientations displayed more motivation to perform leader self-development and more skilled at performing instructional and self-regulatory processes. Higher-self-development motivation and skill resulted in greater reported self-development activities Surprisingly, organzitional support reduced the magnitude of this relationship This study concludes with implications for future research on and practice of leader self-development activities Published by Elsevier Inc C1 [Boyce, Lisa A.; Zaccaro, Stephen J.] George Mason Univ, Dept Psychol, Fairfax, VA 22030 USA. [Wisecarver, Michelle Zazanis] USA, Res Inst, Arlington, VA USA. RP Boyce, LA (reprint author), USAF Acad, Inst Informat Technol Applicat, Colorado Springs, CO 80840 USA. NR 132 TC 21 Z9 22 U1 5 U2 22 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1048-9843 J9 LEADERSHIP QUART JI Leadersh. Q. PD FEB PY 2010 VL 21 IS 1 BP 159 EP 178 DI 10.1016/j.leaqua.2009.10.012 PG 20 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 554LW UT WOS:000274437500012 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Yalta: The Price of Peace SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD FEB 1 PY 2010 VL 135 IS 2 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 549ZN UT WOS:000274094800157 ER PT J AU Kuehn, JT AF Kuehn, John T. TI GUSTAVUS VASA FOX UNION NAVY: A Biography SO MARINERS MIRROR LA English DT Book Review C1 [Kuehn, John T.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC NAUTICAL RESEARCH PI LONDON PA NATIONAL MARITIME MUSEUM GREENWICH, LONDON SE10 9NF, ENGLAND SN 0025-3359 J9 MARINERS MIRROR JI Mar. Mirror PD FEB PY 2010 VL 96 IS 1 BP 109 EP 110 PG 2 WC History SC History GA 559WD UT WOS:000274857900028 ER PT J AU Swedler, DI Knapik, JJ Grier, T Jones, BH AF Swedler, David I. Knapik, Joseph J. Grier, Tyson Jones, Bruce H. TI Validity of Plantar Surface Visual Assessment as an Estimate of Foot Arch Height SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE BONY ARCH INDEX; BMI; BASIC TRAINING; WET TEST; LIGHT BOX ID MEDIAL LONGITUDINAL ARCH; PREPUBESCENT CHILDREN; RELIABILITY; FOOTPRINT; INDEX; FLAT; FEET; FAT; CHARACTERIZE AB SWEDLER, D. I., J. J. KNAPIK, T. GRIER, and B. H. JONES. Validity of Plantar Surface Visual Assessment as an Estimate of Foot Arch Height. Med. Sci. Sports Exerc., Vol. 42, No. 2, pp. 375-380, 2010. Purpose: Popular running magazines and running shoe companies advise using the shape of the weight-bearing plantar surface of the foot as a basis for selecting a proper type of running shoe to reduce injury risk. The imprint is assumed to reflect the height of the medial longitudinal arch (MLA). This study examined the assumption that plantar surface morphology was a surrogate for height of the MLA. Methods: Recruits (n = 3968) entering US Army Basic Combat Training had their plantar foot surfaces assessed visually as low, normal, or high by two raters who viewed imprints of the plantar foot surface. Actual arch height was measured with calipers as distance from the standing surface to the inferior medial border of the navicular tuberosity. Measured MLA heights were compared with plantar surface imprints to evaluate the effectiveness of visual inspection as a means of arch height classification. Results: For the right foot, individuals with low, normal, or high plantar shapes had a mean +/- SD arch height of 33.5 +/- 6.8, 40.4 +/- 7.2, and 43.1 +/- 7.3 mm, respectively (ANOVA, P < 0.01); however, the individuals' measured MLA heights fell into the corresponding plantar shape percentiles (low, normal, high) only 65% of the time. Increased body mass index (BMI) decreased correct assessment of the MLA. Conclusions: Visual assessment of indicating progressively higher plantar shapes corresponded to progressively higher average differences in measured arch heights; nonetheless, there was considerable overlap among the three plantar shapes with 35% of plantar shapes being misclassified compared with measured arch height, especially among individuals with higher BMI. C1 [Swedler, David I.; Knapik, Joseph J.; Grier, Tyson; Jones, Bruce H.] USA, Publ Hlth Command Provis, Aberdeen Proving Ground, MD USA. [Swedler, David I.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. RP Swedler, DI (reprint author), Directorate Epidemiol & Dis Surveillance, 3501 St Paul St,Apt 540, Baltimore, MD 21218 USA. EM dswedler@jhsph.edu FU US Army Center for Health Promotion and Preventive Medicine; US Defense Safety Oversight Council FX This research was supported in part by an appointment to the Student Research Participation Program at the US Army Center for Health Promotion and Preventive Medicine administered by the Oak Ridge Institute for Science and Education through an interagency agreement with the US Department of Energy and USACHPPM.; This study was funded by US Defense Safety Oversight Council, Military Physical Training Task Force Grant. NR 27 TC 7 Z9 7 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD FEB PY 2010 VL 42 IS 2 BP 375 EP 380 DI 10.1249/MSS.0b013e3181b571cc PG 6 WC Sport Sciences SC Sport Sciences GA 549VG UT WOS:000274081800020 PM 19927021 ER PT J AU Dongare, AM Rajendran, AM Lamattina, B Brenner, DW Zikry, MA AF Dongare, A. M. Rajendran, A. M. Lamattina, B. Brenner, D. W. Zikry, M. A. TI Atomic-Scale Study of Plastic-Yield Criterion in Nanocrystalline Cu at High Strain Rates SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID MOLECULAR-DYNAMICS SIMULATION; MECHANICAL-BEHAVIOR; METALLIC-GLASS; SPALL STRENGTH; DEFORMATION; ALUMINUM; COPPER; DISLOCATIONS; NUCLEATION; SURFACE AB Large-scale molecular dynamics (MD) simulations are used to understand the macroscopic yield behavior of nanocrystalline Cu with an average grain size of 6 nm at high strain rates. The MD simulations at strain rates varying from 10(9) s(-1) to 8 x 10(9) s(-1) suggest an asymmetry in the flow stress values in tension and compression, with the nanocrystalline metal being stronger in compression than in tension. The tension-compression strength asymmetry is very small at 10(9) s(-1), but increases with increasing strain rate. The calculated yield stresses and flow stresses under combined biaxial loading conditions (X-Y) gives a locus of points that can be described with a traditional ellipse. An asymmetry parameter is introduced that allows for the incorporation of the small tension-compression asymmetry. The biaxial yield surface (X-Y) is calculated for different values of stress in the Z direction, the superposition of which gives a full three-dimensional (3-D) yield surface. The 3-D yield surface shows a cylinder that is symmetric around the hydrostatic axis. These results suggest that a von Mises-type yield criterion can be used to understand the macroscopic deformation behavior of nanocrystalline Cu with a grain size in the inverse Hall-Petch regime at high strain rates. C1 [Dongare, A. M.; Zikry, M. A.] N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. [Dongare, A. M.; Brenner, D. W.] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. [Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. [Lamattina, B.] USA, Res Off, Res Triangle Pk, NC 27703 USA. RP Dongare, AM (reprint author), N Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA. EM amdongare@ncsu.edu RI Brenner, Donald/D-1741-2009; Dongare, Avinash/A-3470-2009; OI Dongare, Avinash/0000-0003-3189-3588 FU Army Research Office (ARO) FX The research is supported by the Army Research Office (ARO) through the National Research Council Research Associateship Program. NR 34 TC 14 Z9 14 U1 1 U2 20 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD FEB PY 2010 VL 41A IS 2 BP 523 EP 531 DI 10.1007/s11661-009-0113-x PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 539GT UT WOS:000273242700024 ER PT J AU Aldous, WK Co, EM Hamilton, L AF Aldous, Wade K. Co, Edgie-Mark Hamilton, Lanette TI Establishing a Quality Assurance Program in the Clinical Laboratory in the Combat Zone SO MILITARY MEDICINE LA English DT Editorial Material C1 [Aldous, Wade K.; Co, Edgie-Mark] 10th Combat Support Hosp, Lab Serv, APO, AE 09348 USA. [Hamilton, Lanette] Tripler Army Med Ctr, Dept Pathol, Honolulu, HI 96859 USA. [Hamilton, Lanette] Tripler Army Med Ctr, Area Lab Serv, Honolulu, HI 96859 USA. RP Aldous, WK (reprint author), 10th Combat Support Hosp, Lab Serv, APO, AE 09348 USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2010 VL 175 IS 2 BP 77 EP 79 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 582GO UT WOS:000276584900003 PM 20180472 ER PT J AU Paniagua, FA AF Paniagua, Freddy A. TI Some Comments to Further Improve the DoDSER SO MILITARY MEDICINE LA English DT Editorial Material C1 USA, Behav & Social Hlth Outcomes Program, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Paniagua, FA (reprint author), USA, Behav & Social Hlth Outcomes Program, Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2010 VL 175 IS 2 BP 80 EP 81 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA 582GO UT WOS:000276584900004 PM 20180473 ER PT J AU Kashani, M Eliasson, A Chrosniak, L Vernalis, M AF Kashani, Mariam Eliasson, Arn Chrosniak, Linda Vernalis, Marina TI Taking Aim at Nurse Stress: A Call to Action SO MILITARY MEDICINE LA English DT Article ID SLEEP; MORTALITY; HEALTH AB The study investigates stress levels and related behaviors of nurses in a military medical center during wartime. In 2007, nurses completed a questionnaire survey with objective validation of data in a subsample using actigraphy over 12 weeks. Of 270 nurses, 255 (94%) returned surveys. A total of 81% reported moderately high or high stress with sources listed as work (66%) and fatigue (39%). Many reported coming to work despite feeling ill and/or stressed (13.6 days/3 months). In contrast, morale was high or moderately high in 71%. Nurses reported an average of 5.5 hours of sleep/night, 8.8 h/wk taken for self, and 3.8 h/wk for exercise. Actigraphy data showed an average of 6.0 hours of sleep/night. These findings highlight a mismatch between stress levels and coping perceptions indicating an inability to properly care for self. To manage the effects of chronic stress, nurse leaders should implement systems targeting healthy life balance. C1 [Kashani, Mariam; Eliasson, Arn; Vernalis, Marina] Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, Washington, DC 20307 USA. [Chrosniak, Linda] George Mason Univ, Dept Psychol, Arlington, VA 22201 USA. RP Kashani, M (reprint author), Walter Reed Army Med Ctr, Integrat Cardiac Hlth Project, 6900 Georgia Ave, Washington, DC 20307 USA. RI Dopko, Rae/J-7437-2015 NR 23 TC 4 Z9 4 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 2010 VL 175 IS 2 BP 96 EP 100 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 582GO UT WOS:000276584900009 PM 20180478 ER PT J AU Furusato, B Ali, A Ts'o, PO Lum, ZP Srivastava, S Brassell, S McLead, DG Sesterhenn, IA AF Furusato, B. Ali, A. Ts'o, P. O. Lum, Z. P. Srivastava, S. Brassell, S. McLead, D. G. Sesterhenn, I. A. TI Assessment of Circulating Tumor Cells (CTCs) in Low Tumor Volume Prostate Cancer Patients SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 20-26, 2010 CL Washington, DC SP US & Canadian Acad Pathol C1 Armed Forces Inst Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. CCC Diagnost LLC, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD FEB PY 2010 VL 23 SU 1 MA 850 BP 192A EP 192A PG 1 WC Pathology SC Pathology GA 556HX UT WOS:000274582501185 ER PT J AU Furusato, B Parker, P Nydam, T Rice, K Srivastava, S Brassell, S McLeod, DG Sesterhenn, IA AF Furusato, B. Parker, P. Nydam, T. Rice, K. Srivastava, S. Brassell, S. McLeod, D. G. Sesterhenn, I. A. TI Extensive Multifocal Prostatic Adenocarcinomas (Greater Than 20) in Radical Prostatectomy Specimens of Young Men SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 20-26, 2010 CL Washington, DC SP US & Canadian Acad Pathol C1 Armed Forces Inst Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD FEB PY 2010 VL 23 SU 1 MA 849 BP 192A EP 192A PG 1 WC Pathology SC Pathology GA 556HX UT WOS:000274582501184 ER PT J AU Summers, TA Clifton, GT Gates, JD Dobson, L Horkayne-Szakely, I Shaw, JC Nissan, A Sandberg, GD Peoples, GE Stojadinovic, A AF Summers, T. A. Clifton, G. T. Gates, J. D. Dobson, L. Horkayne-Szakely, I. Shaw, J. C. Nissan, A. Sandberg, G. D. Peoples, G. E. Stojadinovic, A. TI Assessment of Immunohistochemical Protein Expression in Tissue Microarrays Using Virtual Microscopic Image Analysis SO MODERN PATHOLOGY LA English DT Meeting Abstract CT 99th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology CY MAR 20-26, 2010 CL Washington, DC SP US & Canadian Acac Pathol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Brooke Army Med Ctr, San Antonio, TX USA. SlidePath, Dublin, Ireland. Armed Forces Inst Pathol, Washington, DC 20306 USA. Hadassah Univ Hosp Mt Scopus, Jerusalem, Israel. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0893-3952 J9 MODERN PATHOL JI Mod. Pathol. PD FEB PY 2010 VL 23 SU 1 MA 1499 BP 336A EP 336A PG 1 WC Pathology SC Pathology GA 556HX UT WOS:000274582502180 ER PT J AU Bunya, S Dietrich, JC Westerink, JJ Ebersole, BA Smith, JM Atkinson, JH Jensen, R Resio, DT Luettich, RA Dawson, C Cardone, VJ Cox, AT Powell, MD Westerink, HJ Roberts, HJ AF Bunya, S. Dietrich, J. C. Westerink, J. J. Ebersole, B. A. Smith, J. M. Atkinson, J. H. Jensen, R. Resio, D. T. Luettich, R. A. Dawson, C. Cardone, V. J. Cox, A. T. Powell, M. D. Westerink, H. J. Roberts, H. J. TI A High-Resolution Coupled Riverine Flow, Tide, Wind, Wind Wave, and Storm Surge Model for Southern Louisiana and Mississippi. Part I: Model Development and Validation SO MONTHLY WEATHER REVIEW LA English DT Article ID SHALLOW-WATER EQUATIONS; DATA SET; HURRICANE; FLORIDA; FIELDS AB A coupled system of wind, wind wave, and coastal circulation models has been implemented for southern Louisiana and Mississippi to simulate riverine flows, tides. wind waves. and hurricane storm surge in the region. The system combines the NOAA Hurricane Research Division Wind Analysis System (H*WIND) and the Interactive Objective Kinematic Analysis (IOKA) kinematic wind analyses, the Wave Model (WAM) offshore and Steady-State Irregular Wave (STWAVE) nearshore wind wave models, and the Advanced Circulation (ADCIRC) basin to channel-scale unstructured grid circulation model. The system emphasizes a high-resolution (down to 50 m) representation of the geometry. bathymetry, and topography nonlinear coupling of all processes including wind wave radiation stress-induced set up; and objective specification of frictional parameters based on land-cover databases and commonly used parameters. Riverine flows and tides are validated for no storm conditions, while winds, wind waves, hydrographs, and high water marks are validated for Hurricanes Katrina and Rita. C1 [Bunya, S.; Dietrich, J. C.; Westerink, J. J.; Westerink, H. J.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Ebersole, B. A.; Smith, J. M.; Jensen, R.; Resio, D. T.] USA, Coastal Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Atkinson, J. H.; Roberts, H. J.] Arcadis Inc, Denver, CO USA. [Luettich, R. A.] Univ N Carolina, Inst Marine Sci, Chapel Hill, NC USA. [Dawson, C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Cardone, V. J.; Cox, A. T.] Oceanweather Inc, Cos Cob, CT USA. [Powell, M. D.] NOAA, Atlantic Oceanog & Meteorol Lab, Hurricane Res Div, Miami, FL 33149 USA. RP Westerink, JJ (reprint author), Univ Notre Dame, Dept Civil Engn & Geol Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. EM jjw@nd.edu RI Dietrich, Joel/E-5161-2011; Powell, Mark/I-4963-2013 OI Dietrich, Joel/0000-0001-5294-2874; Powell, Mark/0000-0002-4890-8945 FU USACE Interagency Performance Evaluation Task Force; USACE Louisiana Coastal Protection and Restoration Study, the USACE New Orleans District, and the USACE Hurricane Protection Office; Federal Emergency Management Agency Region 6; USACE System-Wide Water Resources and MOR-PHOS Programs; Department of Homeland Security Center of Excellence in Natural Hazards, Coastal Infrastructure, and Emergency Managemen; National Oceanic and Atmospheric Administration Integrated Ocean Observing System Program; U.S. Army Engineer Research and Development Center; Department of Defense Supercomputing Resource Center; University of Texas at Austin, Texas Advanced Computing Center; National Science Foundation [DMS06-20696, OCI-0746232]; Office of Naval Research [N00014-06-1-0285] FX Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corps of Engineers (USACE). This work was supported by the USACE Interagency Performance Evaluation Task Force; the Joint Coastal Surge Study in support of the USACE Louisiana Coastal Protection and Restoration Study, the USACE New Orleans District, and the USACE Hurricane Protection Office; the Federal Emergency Management Agency Region 6; and the USACE System-Wide Water Resources and MOR-PHOS Programs; the Department of Homeland Security Center of Excellence in Natural Hazards, Coastal Infrastructure, and Emergency Management; and the National Oceanic and Atmospheric Administration Integrated Ocean Observing System Program. Computational resources and support were provided by the U.S. Army Engineer Research and Development Center, Department of Defense Supercomputing Resource Center, and the University of Texas at Austin, Texas Advanced Computing Center. ADCIRC model development was supported by awards from the USACE, the National Science Foundation (DMS06-20696 and OCI-0746232), and the Office of Naval Research (N00014-06-1-0285). NR 50 TC 121 Z9 121 U1 3 U2 33 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0027-0644 J9 MON WEATHER REV JI Mon. Weather Rev. PD FEB PY 2010 VL 138 IS 2 BP 345 EP 377 DI 10.1175/2009MWR2906.1 PG 33 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 572JE UT WOS:000275826400002 ER PT J AU Dietrich, JC Bunya, S Westerink, JJ Ebersole, BA Smith, JM Atkinson, JH Jensen, R Resio, DT Luettich, RA Dawson, C Cardone, VJ Cox, AT Powell, MD Westerink, HJ Roberts, HJ AF Dietrich, J. C. Bunya, S. Westerink, J. J. Ebersole, B. A. Smith, J. M. Atkinson, J. H. Jensen, R. Resio, D. T. Luettich, R. A. Dawson, C. Cardone, V. J. Cox, A. T. Powell, M. D. Westerink, H. J. Roberts, H. J. TI A High-Resolution Coupled Riverine Flow, Tide, Wind, Wind Wave, and Storm Surge Model for Southern Louisiana and Mississippi. Part II: Synoptic Description and Analysis of Hurricanes Katrina and Rita SO MONTHLY WEATHER REVIEW LA English DT Article AB Hurricanes Katrina and Rita were powerful storms that impacted southern Louisiana and Mississippi during the 2005 hurricane season. In Part I, the authors describe and validate a high-resolution coupled riverine flow, tide, wind, wave, and storm surge model for this region. Herein, the model is used to examine the evolution of these hurricanes in more detail. Synoptic histories show how storm tracks, winds, and waves interacted with the topography, the protruding Mississippi River delta, east-west shorelines, manmade structures, and low-lying marshes to develop and propagate storm surge. Perturbations of the model, in which the waves are not included, show the proportional importance of the wave radiation stress gradient induced setup. C1 [Dietrich, J. C.; Bunya, S.; Westerink, J. J.; Westerink, H. J.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Ebersole, B. A.; Smith, J. M.; Jensen, R.; Resio, D. T.] USA, Coastal Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Atkinson, J. H.; Roberts, H. J.] Arcadis Inc, Denver, CO USA. [Luettich, R. A.] Univ N Carolina, Inst Marine Sci, Chapel Hill, NC USA. [Dawson, C.] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA. [Cardone, V. J.; Cox, A. T.] Oceanweather Inc, Cos Cob, CT USA. [Powell, M. D.] NOAA, Atlantic Oceanog & Meteorol Lab, Hurricane Res Div, Miami, FL 33149 USA. RP Westerink, JJ (reprint author), Univ Notre Dame, Dept Civil Engn & Geol Sci, 156 Fitzpatrick Hall, Notre Dame, IN 46556 USA. EM jjw@nd.edu RI Dietrich, Joel/E-5161-2011; Powell, Mark/I-4963-2013 OI Dietrich, Joel/0000-0001-5294-2874; Powell, Mark/0000-0002-4890-8945 FU USACE Interagency Performance Evaluation Task Force; USACE Louisiana Coastal Protection and Restoration Study, the USACE New Orleans District, and the USACE Hurricane Protection Office; Federal Emergency Management Agency Region 6; USACE SystemWide Water Resources and MORPHOS Programs; Department of Homeland Security Center of Excellence in Natural Hazards, Coastal Infrastructure and Emergency Management; National Oceanic and Atmospheric Administration Integrated Ocean Observing System Program; U.S. Army Engineer Research and Development Center, Department of Defense Supercomputing Resource Center; University of Texas at Austin; National Science Foundation [DMS06-20696, OCI-0746232]; Office of Naval Research [N00014-06-1-0285] FX Permission to publish this paper was granted by the Chief of Engineers, U.S. Army Corps of Engineers (USACE). This work was supported by the USACE Interagency Performance Evaluation Task Force; the Joint Coastal Surge Study in support of the USACE Louisiana Coastal Protection and Restoration Study, the USACE New Orleans District, and the USACE Hurricane Protection Office; the Federal Emergency Management Agency Region 6; the USACE SystemWide Water Resources and MORPHOS Programs; the Department of Homeland Security Center of Excellence in Natural Hazards, Coastal Infrastructure and Emergency Management; and the National Oceanic and Atmospheric Administration Integrated Ocean Observing System Program. Computational resources and support were provided by the U.S. Army Engineer Research and Development Center, Department of Defense Supercomputing Resource Center and the University of Texas at Austin, Texas Advanced Computing Center. ADCIRC model development was supported by awards from the USACE, the National Science Foundation (DMS06-20696 and OCI-0746232) and the Office of Naval Research (N00014-06-1-0285). NR 15 TC 81 Z9 81 U1 4 U2 27 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0027-0644 J9 MON WEATHER REV JI Mon. Weather Rev. PD FEB PY 2010 VL 138 IS 2 BP 378 EP 404 DI 10.1175/2009MWR2907.1 PG 27 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 572JE UT WOS:000275826400003 ER PT J AU McMenamin, BW Shackman, AJ Maxwell, JS Bachhuber, DRW Koppenhaver, AM Greischar, LL Davidson, RJ AF McMenamin, Brenton W. Shackman, Alexander J. Maxwell, Jeffrey S. Bachhuber, David R. W. Koppenhaver, Adam M. Greischar, Lawrence L. Davidson, Richard J. TI Validation of ICA-based myogenic artifact correction for scalp and source-localized EEG SO NEUROIMAGE LA English DT Review ID INDEPENDENT COMPONENT ANALYSIS; BLIND SOURCE SEPARATION; EVENT-RELATED POTENTIALS; RESOLUTION ELECTROMAGNETIC TOMOGRAPHY; SIGNAL-SPACE PROJECTION; GAMMA-BAND RESPONSE; BALLISTOCARDIOGRAM ARTIFACT; INDIVIDUAL-DIFFERENCES; AUTOMATIC CORRECTION; OCULAR ARTIFACTS AB Muscle electrical activity. or "electromyogenic" (EMG) artifact, poses a serious threat to the validity of electroencephalography (EEG) investigations in the frequency domain EMG is sensitive to a variety of psychological processes and can mask genuine effects or masquerade as legitimate neurogenic effects across the scalp in frequencies at least as low as the alpha band (8-13 Hz). Although several techniques for correcting myogenic activity have been described, most are subjected to only limited validation attempts Attempts to gauge the impact of EMG correction on intracerebral source models (source "localization" analyses) are rarer still Accordingly. we assessed the sensitivity and specificity of one prominent correction tool, independent component analysis (ICA), on the scalp and in the source-space using high-resolution EEG. Data were collected from 17 participants while neurogenic and myogenic activity was independently varied Several protocols for classifying and discarding components classified as myogenic and non-myogenic artifact (e.g.. Ocular) were systematically assessed, leading to the exclusion of one-third to as much as three-quarters of the variance in the EEG Some, but not all, of these protocols showed adequate performance on the scalp. Indeed. performance was superior to previously validated regression-based techniques. Nevertheless. ICA-based EMG correction exhibited low validity in the intracerebral source-space, likely owing to incomplete separation of neurogenic from myogenic sources. Taken with prior work, this indicates that EMG artifact can Substantially distort estimates of intracerebral spectral activity. Neither regression- nor ICA-based EMG correction techniques provide complete safeguards against such distortions In light of these results, several practical suggestions and recommendations are made for intelligently using ICA to minimize EMG and other common artifacts. (C) 2009 Elsevier Inc. All rights reserved. C1 [McMenamin, Brenton W.; Shackman, Alexander J.; Bachhuber, David R. W.; Koppenhaver, Adam M.; Greischar, Lawrence L.; Davidson, Richard J.] Univ Wisconsin, Lab Affect Neurosci, Waisman Lab Brain Imaging & Behav, Madison, WI 53706 USA. [McMenamin, Brenton W.] Univ Minnesota, Dept Psychol, Ctr Cognit Sci, Minneapolis, MN 55455 USA. [Maxwell, Jeffrey S.] USA, Res Lab, Aberdeen, MD USA. RP McMenamin, BW (reprint author), Univ Wisconsin, Lab Affect Neurosci, Waisman Lab Brain Imaging & Behav, 1202 W Johnson St, Madison, WI 53706 USA. RI Shackman, Alexander/B-3458-2009; OI Shackman, Alexander/0000-0002-3629-4704 FU NIMH [P50-MH069315, R37/R01-MH43454, T32-HD007151] FX The first two authors (BWM and AJS) contributed equally to this research. We thank Alanna Clare, Donna Cole, Isa Dolski, Andre Mouraux, and Aaron Teche for assistance and three anonymous reviewers for thoughtful comments. This work was supported by the NIMH (P50-MH069315 and R37/R01-MH43454 to RJD; BWM was supported by T32-HD007151). NR 107 TC 88 Z9 88 U1 6 U2 16 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1053-8119 EI 1095-9572 J9 NEUROIMAGE JI Neuroimage PD FEB 1 PY 2010 VL 49 IS 3 BP 2416 EP 2432 DI 10.1016/j.neuroimage.2009.10.010 PG 17 WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA 544BN UT WOS:000273626400045 PM 19833218 ER PT J AU Trested, DG Goforth, R Kirk, JP Isely, JJ AF Trested, Drew G. Goforth, Reuben Kirk, James P. Isely, J. Jeffery TI Survival of Shovelnose Sturgeon after Abdominally Invasive Endoscopic Evaluation SO NORTH AMERICAN JOURNAL OF FISHERIES MANAGEMENT LA English DT Editorial Material ID PALLID STURGEON; REPRODUCTIVE STAGE; SEX; ULTRASONOGRAPHY; MATURITY; GENDER; RIVER; SHORTNOSE; MOVEMENTS; FISH AB The development of effective and minimally invasive techniques to determine gender and gonad developmental stage is particularly important in performing accurate fisheries assessments for use in conservation and restoration. The initial and latent survival of shovelnose sturgeon Scaphirhynchus platorynchus was assessed after exposure to a modified endoscopic technique designed to collect that biological information. Rather than inserting the endoscope through the urogenital canal or directly into the body cavity, we inserted a threaded trocar through a ventral incision and used a low-pressure air supply attached to the trocar to gently insufflate the body cavity. The initial survival of both experimental and control shovelnose sturgeon was 100%. Latent survival was 100% and 90% for the experimental and control fish, respectively. Our study suggests that incision endoscopy coupled with insufflation of the body cavity through the use of a trocar and an air supply is a safe and effective way to determine gender and examine the gonad developmental stage of shovelnose sturgeon. The short duration of the procedure and the high postprocedure survival suggest that this technique is suitable for shovelnose sturgeon and perhaps for the evaluation of other endangered fish species (e. g., pallid sturgeon S. alba) as well. C1 [Trested, Drew G.] Clemson Univ, Dept Forestry & Nat Resources, Clemson, SC 29631 USA. [Goforth, Reuben] Purdue Univ, Dept Forestry & Nat Resources, W Lafayette, IN 47907 USA. [Kirk, James P.] USA, Corps Engineers, Waterways Expt Stn, Vicksburg, MS 39180 USA. [Isely, J. Jeffery] Clemson Univ, US Geol Survey, S Carolina Cooperat Fish & Wildlife Res Unit, Clemson, SC 29631 USA. RP Trested, DG (reprint author), Normandeau Associates, 25 Nashua Rd, Bedford, NH 03110 USA. EM dtrested@normandeau.com RI Goforth, Reuben/B-1646-2010 OI Goforth, Reuben/0000-0001-6891-3146 NR 25 TC 3 Z9 4 U1 1 U2 1 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE SUITE 110, BETHESDA, MD 20814-2199 USA SN 0275-5947 J9 N AM J FISH MANAGE JI North Am. J. Fish Manage. PD FEB PY 2010 VL 30 IS 1 BP 121 EP 125 DI 10.1577/M09-125.1 PG 5 WC Fisheries SC Fisheries GA 588ZR UT WOS:000277113900011 ER PT J AU Lin, YJ He, ZL Rosskopf, EN Conn, KL Powell, CA Lazarovits, G AF Lin, Youjian He, Zhenli Rosskopf, Erin N. Conn, Kenneth L. Powell, Charles A. Lazarovits, George TI A Nylon Membrane Bag Assay for Determination of the Effect of Chemicals on Soilborne Plant Pathogens in Soil SO PLANT DISEASE LA English DT Article ID LIQUID SWINE MANURE; KILL VERTICILLIUM-DAHLIAE; RALSTONIA-SOLANACEARUM; PHYTOPHTHORA-NICOTIANAE; LABORATORY METHOD; POTATO SCAB; SURVIVAL; MICROSCLEROTIA; IMMUNOASSAY; FUNGICIDES AB A new nylon membrane bag (NMB) assay was developed for studies to determine the effect of chemicals added to soil on survival of soilborne plant pathogens. The rapid and effective assay can be used to study organisms for which there are no selective media or for which a selective medium is expensive or difficult to prepare. This assay consists of placing pathogens inside a bag made of small-pore (0.22-mu m) nylon filtration membrane, which is placed in soil and later retrieved to determine survival of the pathogens on nonselective media. Chemicals but not other microorganisms can enter the bag from the soil. Using this assay, Streptomyces scabies, Fusarium oxysporum f. sp. lycopersici race 3, and Ralstonia solanacearum were successfully recovered from soil after 72 h as demonstrated by growth on a semiselective Streptomyces medium (S. scabies) or nonselective potato dextrose agar medium (F. oxysporum f. sp. lycopersici race 3 and R. solanacearum) with minimal microbial contamination. Addition of acetic acid (200 mM) to soil killed 100% of S. scabies. SPK (a mixture of organic chemicals) at a concentration of 1,500 mg kg(-1) of soil killed 83.3% of F oxysporum f. sp. lycopersici race 3 culture plugs, 100% of E oxysporum f. sp. lycopersici race 3 spores, and 97.2% of R. solanacearum cells. SPK at 1,000 mg kg-1 of soil killed 50% of F. oxysporum f. sp. lycopersici race 3 culture plugs, 68.2% of F oxysporum f. sp. lycopersici race 3 spores, and 12% of R. solanacearum. Benlate (500 to 1,500 mg kg-1 of soil) did not kill the culture plugs of F oxysporum f. sp. lycopersici race 3 but reduced the growth rate of E oxysporum f. sp. lycopersici race 3. Benlate (500, 1,000, and 1,500 mg kg(-1) of soil) reduced F. oxysporum f. sp. lycopersici race 3 spore germination by 39.4, 49.3, and 50.4%, respectively. Streptomycin sulfate (1,500, 800, 400, and 200 mg kg-1 of soil) caused 75.3, 21, 11.9, and 0.9% mortality, respectively, of R. solanacearum. C1 [Lin, Youjian; He, Zhenli; Powell, Charles A.] Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL 34945 USA. [Conn, Kenneth L.; Lazarovits, George] Agr & Agri Food Canada, So Crop Protect & Food Res Ctr, London, ON N5V 4T3, Canada. [Lin, Youjian] Fujian Agr & Forestry Univ, Plant Protect Coll, Fuzhou 350002, Fujian, Peoples R China. [Rosskopf, Erin N.] USA, Hort Res Lab, Ft Pierce, FL 34945 USA. RP Powell, CA (reprint author), Univ Florida, Indian River Res & Educ Ctr, Ft Pierce, FL 34945 USA. EM capowell@ufl.edu RI He, Zhenli/R-1494-2016 OI He, Zhenli/0000-0001-7761-2070 NR 48 TC 3 Z9 3 U1 1 U2 11 PU AMER PHYTOPATHOLOGICAL SOC PI ST PAUL PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA SN 0191-2917 J9 PLANT DIS JI PLANT DIS. PD FEB PY 2010 VL 94 IS 2 BP 201 EP 206 DI 10.1094/PDIS-94-2-0201 PG 6 WC Plant Sciences SC Plant Sciences GA 547JI UT WOS:000273883000008 ER PT J AU Ciezak, JA AF Ciezak, Jennifer A. TI The High-Pressure Characterization of Energetic Materials: Diaminotetrazolium Nitrate (HDAT-NO3) SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Diaminotetrazolium Nitrate; Diamond Anvil Cell; HDAT-NO3; High-Pressure; Energetic Material ID VIBRATIONAL SPECTROSCOPY; INDUCED DECOMPOSITION; RDX; HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE; CRYSTALS AB In-situ high-pressure room temperature synchrotron X-ray diffraction and optical Raman and infrared spectroscopy were used to examine the structural properties, equation of state, and vibrational dynamics of diaminotetrazolium nitrate (HDAT-NO3)The X-ray measurements show that the pressure-volume relations remain smooth to 12 GPa. X-ray diffraction measurements at pressures above 12 GPa were not possible in this study because of sample decomposition resulting from several factors. X-ray diffraction reveals no indication of a phase transition to at least 12 GPa, but slight variations in the c/b unit cell ratio suggests modifications within the hydrogen bonding sub-lattice. Vibrational measurements show the ambient phase of HDAT-NO3 to remain the dominant phase to 33 GPa. C1 USA, Res Lab, RDRL WMB D, Aberdeen Proving Ground, MD 21005 USA. RP Ciezak, JA (reprint author), USA, Res Lab, RDRL WMB D, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM jciezak@arl.army.mil FU U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-AC02-98CH10886] FX Thanks are due to Dr. Jingzhu Hu and Dr. Zhenxian Liu of BNL for their technical assistance. Use of the National Synchrotron Light Source, Brookhaven National Laboratory, was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-98CH10886. NR 23 TC 6 Z9 6 U1 0 U2 8 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2010 VL 35 IS 1 BP 24 EP 30 DI 10.1002/prep.200800086 PG 7 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 565AK UT WOS:000275260200004 ER PT J AU McNesby, KL Homan, BE Ritter, JJ Quine, Z Ehlers, RZ McAndrew, BA AF McNesby, Kevin L. Homan, Barrie E. Ritter, John J. Quine, Zachary Ehlers, Rachel Z. McAndrew, Brendan A. TI Afterburn Ignition Delay and Shock Augmentation in Fuel Rich Solid Explosives SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Chemical Kinetics; Energy Management; Explosives; Ignition Delay; Shock Augmentation AB We present experimental and computational results that explain some aspects of measured energy release in explosions of unconfined trinitrotoluene [TNT, C(6)H(2)(NO(2))(3)CH(3)], and an aluminum-containing explosive formulation, and show how this energy release can influence shock wave velocities in air. In our interpretation, energy release is divided into early, middle, and late time regimes. An explanation is provided for the interdependence of the time regimes and their influence on the rate at which energy (detonation/explosion and afterburn) is released. We use a merging of the thermodynamic and chemical kinetic processes that predicts how chemical kinetics may determine the time delay of the afterburn of combustible gases produced by the initial detonation/explosion/fast reaction. The thermodynamic computer code CHEETAH is used to predict gaseous and solid products of early time energy release, and a chemical kinetic reaction mechanism (CHEMKIN format) is used to describe the subsequent afterburn of the gas phase products in air. Results of these calculations are compared with field measurements of unconfined explosions of 2 kg charge weights of TNT and an aluminum-containing explosive formulation. C1 [McNesby, Kevin L.; Homan, Barrie E.; Ritter, John J.; Quine, Zachary; Ehlers, Rachel Z.; McAndrew, Brendan A.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP McNesby, KL (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM mcnesby@arl.army.mil FU Defense Threat Reduction Agency (DTRA) FX This work was partly supported by the Defense Threat Reduction Agency (DTRA). Richard Lottero contributed to this work. NR 15 TC 14 Z9 17 U1 0 U2 2 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD FEB PY 2010 VL 35 IS 1 BP 57 EP 65 DI 10.1002/prep.200800084 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 565AK UT WOS:000275260200009 ER PT J AU Paul, MA Miller, JC Gray, GW Love, RJ Lieberman, HR Arendt, J AF Paul, Michel A. Miller, James C. Gray, Gary W. Love, Ryan J. Lieberman, Harris R. Arendt, Josephine TI Melatonin treatment for eastward and westward travel preparation SO PSYCHOPHARMACOLOGY LA English DT Article DE Jet lag; Melatonin treatment; Dim light melatonin onset; Circadian phase shift ID HUMAN CIRCADIAN-RHYTHMS; PHASE RESPONSE CURVE; JET-LAG; HUMANS; LIGHT; ALLEVIATION; TEMPERATURE; MARKER; NIGHT AB Melatonin is recommended for hastening adaptation to phase shift, but there is little information on appropriate formulations. We evaluated the efficacy of three melatonin formulations for circadian phase advance and delay: (a) 3 mg regular release (RR), (b) 3 mg sustained release (SR), and (c) 3 mg surge-sustained release (SSR; consisting of 1 mg RR and 2 mg SR). Circadian phase was assessed by salivary melatonin dim light melatonin onset (DLMO) or offset (MelOff) using thresholds of (1) 1.0 pg/ml and (2) mean baseline + 2 standard deviations (BL + 2SD). Subjects spent from Tuesday evenings until Thursday in the laboratory. Melatonin (or placebo) was administered at 1600 hours (phase advance) Wednesday, with DLMO assessment on Tuesday and Thursday and at 0600 hours (phase delay) Wednesday, with DLMO assessment Tuesday, Wednesday, and MelOff Thursday morning. Phase advances using the 1.0 pg/ml DLMO were as follows: placebo, 0.73 h; RR, 1.23 h (p < 0.003); SR, 1.44 h (p < 0.0002); SSR, 1.16 h (p < 0.012), with no difference between formulations. Similar but smaller phase advances were found with BL + 2SD. Using MelOff, posttreatment phase position for the RR formulation was delayed compared to placebo by 1.12 h (p < 0.012), 1.0 pg/ml, and 0.75 h (p < 0.036), BL+2SD. Phase shifts for the SR and SSR conditions could not be determined due to persistent high melatonin levels during sampling times. Similar phase advances were induced by all formulations, and slow clearance of slow release preparations impeded the determination of phase delays. Appropriately timed 0.5 mg melatonin doses may avoid these problems. C1 [Paul, Michel A.; Gray, Gary W.] Def Res & Dev Canada, Toronto, ON M3M 3B9, Canada. [Miller, James C.] Miller Ergon, San Antonio, TX USA. [Love, Ryan J.] McMaster Univ, Sch Biomed Engn, Hamilton, ON, Canada. [Lieberman, Harris R.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Arendt, Josephine] Univ Surrey, Ctr Chronobiol, Surrey, England. RP Paul, MA (reprint author), Def Res & Dev Canada, 1133 Sheppard Ave W,POB 2000, Toronto, ON M3M 3B9, Canada. EM michel.paul@drdc-rddc.gc.ca RI Love, Ryan/I-8597-2012; OI Love, Ryan/0000-0003-1759-2957; Miller, James/0000-0002-3897-8376 FU Canadian Forces FX The views, opinions, and/or findings in this report are those of the authors and should not be construed as an official Defence Research & Development Canada (DRDC), Department of National Defence (DND) Canada, or US Department of Defense (DoD) position, policy or decisions, unless so designated by other official documentation. Citations of commercial organizations and trade names in this report do not constitute an official DRDC, DND Canada, or US DoD endorsement or approval of the products or services of these organizations. Funding for this research was provided by the Canadian Forces. NR 29 TC 14 Z9 14 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD FEB PY 2010 VL 208 IS 3 BP 377 EP 386 DI 10.1007/s00213-009-1737-7 PG 10 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA 544BV UT WOS:000273627400004 PM 20013115 ER PT J AU Lesage, S AF Lesage, Suzanne TI Pearls: Sleep Disorders SO SEMINARS IN NEUROLOGY LA English DT Article DE Sleep disorders; restless leg syndrome; periodic limb movement disorder; parasomnia ID RESTLESS LEGS SYNDROME; PERIODIC LIMB MOVEMENTS; REM-SLEEP; BEHAVIOR DISORDER; APNEA; SLEEPWALKING; POPULATION AB Sleep disorders and sleep complaints are common in the neurology patient. A good history can often be started with just a few well-worded questions to help identify the major sleep disorders. Identifying sleep-related disorders can help the neurologist broaden the differential diagnosis and treat disorders that can contribute significantly to many comorbidities of other neurologic diseases. C1 Walter Reed Army Med Ctr, Sleep Disorders Ctr, Washington, DC 20307 USA. RP Lesage, S (reprint author), Walter Reed Army Med Ctr, Sleep Disorders Ctr, 6900 Georgia Ave,Bldg 2,7623, Washington, DC 20307 USA. EM Suzanne.lesage@us.army.mil NR 27 TC 0 Z9 0 U1 0 U2 1 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0271-8235 J9 SEMIN NEUROL JI Semin. Neurol. PD FEB PY 2010 VL 30 IS 1 BP 90 EP 96 DI 10.1055/s-0029-1245003 PG 7 WC Clinical Neurology SC Neurosciences & Neurology GA 551EX UT WOS:000274190500018 PM 20127589 ER PT J AU Huppmann, MV Johnson, WB Javitt, MC AF Huppmann, Michael V. Johnson, William B. Javitt, Marcia C. TI Radiation Risks from Exposure to Chest Computed Tomography SO SEMINARS IN ULTRASOUND CT AND MRI LA English DT Article ID ACUTE PULMONARY-EMBOLISM; AAPM/RSNA PHYSICS TUTORIAL; CORONARY-ARTERY-DISEASE; TUBE CURRENT MODULATION; ATOMIC-BOMB SURVIVORS; MULTIDETECTOR ROW CT; LOW-DOSE CT; NORTH-AMERICAN-SOCIETY; BREAST-CANCER RISK; LUNG-CANCER C1 [Huppmann, Michael V.; Johnson, William B.; Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Javitt, MC (reprint author), Walter Reed Army Med Ctr, Dept Radiol, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 141 TC 12 Z9 12 U1 0 U2 5 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0887-2171 EI 1558-5034 J9 SEMIN ULTRASOUND CT JI Semin. Ultrasound CT MRI PD FEB PY 2010 VL 31 IS 1 BP 14 EP 28 DI 10.1053/j.sult.2009.09.003 PG 15 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 584LN UT WOS:000276753500004 PM 20102692 ER PT J AU Eliasson, AH Lettieri, CJ Eliasson, AH AF Eliasson, Arne H. Lettieri, Christopher J. Eliasson, Arn H. TI Early to bed, early to rise! Sleep habits and academic performance in college students SO SLEEP AND BREATHING LA English DT Article DE Academic performance; Total sleep time; Bed time; Wake time; Circadian rhythm ID ADOLESCENTS; PREVALENCE; PATTERNS; BEHAVIOR; TIME AB Prior studies have placed emphasis on the need for adequate total sleep time for student performance. We sought to investigate the relative importance of total sleep time compared to the timing of sleep and wakefulness for academic performance. We performed a questionnaire-based survey of college students in October 2007. The questionnaire gathered detailed information on sleep habits including naps, reasons for missing sleep, academic performance, study habits, time spent working outside of school, and stimulant use. Compared to those with the lowest academic performance, students with the highest performance had significantly earlier bedtimes (p = 0.05) and wake times (p = 0.008). Napping tended to be more common among high performers (p = 0.07). Of importance, there were no significant differences in total sleep time with or without naps, weekend sleep habits, study time, gender, race, reasons for staying up at night, nor in use of caffeinated beverages, over-the-counter stimulant pills, or use of prescription stimulants. Timing of sleep and wakefulness correlated more closely with academic performance than total sleep time and other relevant factors. These findings have important implications for programs intended to improve academic performance by targeting sleep habits of students. C1 [Eliasson, Arne H.] Walter Reed Army Med Ctr, Pulm Serv, Silver Spring, MD 20904 USA. [Eliasson, Arne H.] Montgomery Coll, Scholars Program, Rockville, MD 20850 USA. [Lettieri, Christopher J.; Eliasson, Arn H.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Eliasson, AH (reprint author), Walter Reed Army Med Ctr, Pulm Serv, 12515 Davan Dr, Silver Spring, MD 20904 USA. EM aheliasson@aol.com RI Loureiro, Nuno/I-6400-2012 OI Loureiro, Nuno/0000-0002-1166-3219 NR 20 TC 28 Z9 29 U1 7 U2 42 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1520-9512 J9 SLEEP BREATH JI Sleep Breath. PD FEB PY 2010 VL 14 IS 1 BP 71 EP 75 DI 10.1007/s11325-009-0282-2 PG 5 WC Clinical Neurology; Respiratory System SC Neurosciences & Neurology; Respiratory System GA 557RR UT WOS:000274688300012 PM 19603214 ER PT J AU Shrestha, M Shah, A Lettieri, C AF Shrestha, Merica Shah, Anita Lettieri, Christopher TI Dyspnea and Dysentery: A Case Report of Pleuropulmonary Amebiasis SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE Entamoeba histolytica; parasite; pleural infection; pleuropulmonary amebiasis ID DIAGNOSIS AB Pleuropulmonary amebiasis is an uncommon complication of Entamoeba histolytica infection. It typically occurs in endemic regions including Central and South America, Africa and the Indian subcontinent. The case of a previously healthy US Army male stationed in Liberia with an acute onset of fevers, abdominal pain and bloody diarrhea is presented. He developed a productive cough with pleuritic chest pain and imaging revealed multiple liver abscesses, with rupture through the diaphragm causing a large right pleural empyema. A positive Entamoeba histolytica serum antibody and pleural fluid antigen confirmed the diagnosis. Surgical drainage of the pleural empyema and medical treatment with antiparasitics were necessary for symptom and disease resolution. C1 Walter Reed Army Med Ctr, Dept Internal Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Pulm, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Crit Care, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Sleep Med, Washington, DC 20307 USA. RP Shah, A (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Anita.Shah@amedd.army.mil NR 11 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD FEB PY 2010 VL 103 IS 2 BP 165 EP 168 DI 10.1097/SMJ.0b013e3181c0afc1 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 604OS UT WOS:000278289000019 PM 20175253 ER PT J AU Rizzo, JA Naig, AL Johnson, EK AF Rizzo, Julie A. Naig, Anna L. Johnson, Eric K. TI Anorectal Abscess and Fistula-in-Ano: Evidence-Based Management SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Anorectal abscess; Anal fistula; Incontinence ID ENDORECTAL ADVANCEMENT FLAP; COMPLEX ANAL FISTULAS; PRIMARY SPHINCTER RECONSTRUCTION; PERIANAL CROHNS-DISEASE; TERM-FOLLOW-UP; FIBRIN GLUE; CUTTING SETON; FECAL INCONTINENCE; INITIAL-EXPERIENCE; SURGICAL-TREATMENT AB The management of anorectal abscess and anal fistula has changed markedly with time. Invasive methods with high resulting rates of incontinence have given way to sphincter-sparing methods that have a much lower associated morbidity. There has been an increase in reports in the medical literature describing the success rates of the varying methods of dealing with this condition. This article reviews the various methods of treatment and evidence supporting their use and explores advances that may lead to new therapies. C1 [Rizzo, Julie A.; Naig, Anna L.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. [Johnson, Eric K.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. RP Johnson, EK (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM eric.k.johnson@us.army.mil NR 91 TC 27 Z9 31 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD FEB PY 2010 VL 90 IS 1 BP 45 EP + DI 10.1016/j.suc.2009.10.001 PG 25 WC Surgery SC Surgery GA 601KP UT WOS:000278058300006 PM 20109632 ER PT J AU Markell, KW Billingham, RP AF Markell, Katharine W. Billingham, Richard P. TI Pruritus Ani: Etiology and Management SO SURGICAL CLINICS OF NORTH AMERICA LA English DT Article DE Pruritus ani; Dermatologic; Itch ID HEMORRHOIDS; ERYTHRASMA; CROSSOVER; PAIN AB Pruritus ani is a dermatologic condition characterized by an unpleasant itching or burning sensation in the perianal region. This article briefly discusses the incidence and classification of pruritus ani followed by a more lengthy discussion of primary and secondary pruritus ani. The important points are summarized and a simple algorithm is provided for the clinical management of pruritus ani. C1 [Billingham, Richard P.] Swedish Colon & Rectal Clin, Seattle, WA 98104 USA. [Markell, Katharine W.] US Army Med Corps, San Antonio, TX USA. [Markell, Katharine W.] Brooke Army Med Ctr, Div Colon & Rectal Surg, San Antonio, TX USA. [Billingham, Richard P.] Univ Washington, Dept Surg, Seattle, WA 98195 USA. RP Billingham, RP (reprint author), Swedish Colon & Rectal Clin, 1101 Madison St,Suite 500, Seattle, WA 98104 USA. EM rbham@u.washington.edu OI Billingham, Richard/0000-0002-8680-5103 NR 27 TC 8 Z9 8 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0039-6109 J9 SURG CLIN N AM JI Surg. Clin.-North Am. PD FEB PY 2010 VL 90 IS 1 BP 125 EP + DI 10.1016/j.suc.2009.09.007 PG 12 WC Surgery SC Surgery GA 601KP UT WOS:000278058300011 PM 20109637 ER PT J AU Muschler, GF Raut, VP Patterson, TE Wenke, JC Hollinger, JO AF Muschler, George F. Raut, Vivek P. Patterson, Thomas E. Wenke, Joseph C. Hollinger, Jeffrey O. TI The Design and Use of Animal Models for Translational Research in Bone Tissue Engineering and Regenerative Medicine SO TISSUE ENGINEERING PART B-REVIEWS LA English DT Review ID CALVARIAL DEFECT MODEL; PLATELET-RICH PLASMA; POSTERIOR SPINAL-FUSION; MORPHOGENETIC PROTEIN-2 RHBMP-2; MAXILLARY SINUS AUGMENTATION; VERTICAL RIDGE AUGMENTATION; ANTERIOR CRUCIATE LIGAMENT; MICRO-COMPUTED TOMOGRAPHY; THORACIC-DUCT LYMPHOCYTES; BLOOD MONONUCLEAR-CELLS AB This review provides an overview of animal models for the evaluation, comparison, and systematic optimization of tissue engineering and regenerative medicine strategies related to bone tissue. This reviewincludes an overview of major factors that influence the rational design and selection of an animal model. A comparison is provided of the 10 mammalian species that are most commonly used in bone research, and existing guidelines and standards are discussed. This review also identifies gaps in the availability of animal models: (1) the need for assessment of the predictive value of preclinical models for relative clinical efficacy, (2) the need for models that more effectively mimic the wound healing environment and mass transport conditions in the most challenging clinical settings (e.g., bone repair involving large bone and soft tissue defects and sites of prior surgery), and (3) the need for models that allow more effective measurement and detection of cell trafficking events and ultimate cell fate during the processes of bone modeling, remodeling, and regeneration. The ongoing need for both continued innovation and refinement in animal model systems, and the need and value of more effective standardization are reinforced. C1 [Muschler, George F.; Raut, Vivek P.; Patterson, Thomas E.] Cleveland Clin, Lerner Res Inst, Dept Biomed Engn, Cleveland, OH 44106 USA. [Wenke, Joseph C.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Hollinger, Jeffrey O.] Carnegie Mellon Univ, Dept Biomed Engn & Biol Sci, Pittsburgh, PA 15213 USA. RP Muschler, GF (reprint author), Cleveland Clin Fdn, Lerner Res Inst, Dept Biomed Engn, 9500 Euclid Ave ND20, Cleveland, OH 44195 USA. EM muschlg@ccf.org NR 233 TC 91 Z9 92 U1 3 U2 26 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3368 J9 TISSUE ENG PART B-RE JI Tissue Eng. Part B-Rev. PD FEB PY 2010 VL 16 IS 1 BP 123 EP 145 DI 10.1089/ten.teb.2009.0658 PG 23 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 554GJ UT WOS:000274423200013 PM 19891542 ER PT J AU Leshin, J Danielsen, M Credle, JJ Weeks, A O'Connell, KP Dretchen, K AF Leshin, Jonathan Danielsen, Mark Credle, Joel J. Weeks, Andrea O'Connell, Kevin P. Dretchen, Kenneth TI Characterization of ricin toxin family members from Ricinus communis SO TOXICON LA English DT Article DE Ricin; Ricinus communis; Preproricin; Ribosome-inactivating protein; Ricin toxin A-chain; Biodefense ID RIBOSOME-INACTIVATING PROTEINS; A-CHAIN; RNA; CLONING; PLANTS; SITE; GENE AB Ricin inhibits translation by removal of a specific adenine from 28S RNA. The Ricinus communis genome encodes seven full-length ricin family members. All encoded proteins have the ability of hydrolyzing adenine in 28S rRNA. As expected, these proteins also inhibited an in vitro transcription/translation system. These data show that the ricin gene family contains at least seven members that have the ability to inhibit translation and that may contribute to the toxicity of R. communis. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Leshin, Jonathan; Dretchen, Kenneth] Georgetown Univ, Dept Pharmacol, Washington, DC 20057 USA. [Danielsen, Mark; Credle, Joel J.] Georgetown Univ, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA. [Weeks, Andrea] George Mason Univ, Dept Environm Sci & Policy, Fairfax, VA 22030 USA. [O'Connell, Kevin P.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Leshin, J (reprint author), Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20854 USA. EM jleshin@umd.edu RI Danielsen, Mark/B-1606-2008; OI Danielsen, Mark/0000-0002-0923-9945; Weeks, Andrea/0000-0002-0000-4541 FU Defense Threat Reduction Agency FX This research was funded through a subcontract from General Dynamics to Georgetown University from the Defense Threat Reduction Agency. The following reagents were obtained through the NIH Biodefense and Emerging infections Research Resources Repository, MAID, NIH: Ricin Toxin A Subunit with N-terminal Histidine Tag, Recombinant from Escherichia coli, NR-853; Monoclonal Anti-Ricin Toxin A-Chain (produced in vitro), NR-843. NR 10 TC 15 Z9 17 U1 0 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PD FEB-MAR PY 2010 VL 55 IS 2-3 BP 658 EP 661 DI 10.1016/j.toxicon.2009.09.002 PG 4 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 556GU UT WOS:000274579100063 PM 19781564 ER PT J AU Matchett, MR Biggins, DE Carlson, V Powell, B Rocke, T AF Matchett, Marc R. Biggins, Dean E. Carlson, Valerie Powell, Bradford Rocke, Tonie TI Enzootic Plague Reduces Black-Footed Ferret (Mustela nigripes) Survival in Montana SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Black-footed ferrets; Black-tailed prairie dogs; Cynomys ludoviscianus; Deltamethrin; Enzootic; F1-V fusion protein plague vaccine; Mustela nigripes; Plague; Yersinia pestis ID PRAIRIE DOG COLONIES; F1-V FUSION PROTEIN; YERSINIA-PESTIS; PNEUMONIC PLAGUE; SYLVATIC PLAGUE; FLEAS; DYNAMICS; TRANSMISSION AB Black-footed ferrets ( Mustela nigripes) require extensive prairie dog colonies (Cynomys spp.) to provide habitat and prey. Epizootic plague kills both prairie dogs and ferrets and is a major factor limiting recovery of the highly endangered ferret. In addition to epizootics, we hypothesized that enzootic plague, that is, presence of disease-causing Yersinia pestis without any noticeable prairie dog die off, may also affect ferret survival. We reduced risk of plague on portions of two ferret reintroduction areas by conducting flea control for 3 years. Beginning in 2004, about half of the ferrets residing on dusted and nondusted colonies were vaccinated against plague with an experimental vaccine (F1-V fusion protein). We evaluated 6-month reencounter rates ( percentage of animals observed at the end of an interval that were known alive at the beginning of the interval), an index to survival, for ferrets in four treatment groups involving all combinations of vaccination and flea control. For captive-reared ferrets ( 115 individuals observed across 156 time intervals), reencounter rates were higher for vaccinates (0.44) than for nonvaccinates (0.23, p = 0.044) on colonies without flea control, but vaccination had no detectable effect on colonies with flea control ( vaccinates 0.41, nonvaccinates 0.42, p = 0.754). Flea control resulted in higher reencounter rates for nonvaccinates (p = 0.026), but not for vaccinates (p = 0.508). The enhancement of survival due to vaccination or flea control supports the hypothesis that enzootic plague reduces ferret survival, even when there was no noticeable decline in prairie dog abundance. The collective effects of vaccination and flea control compel a conclusion that fleas are required for maintenance, and probably transmission, of plague at enzootic levels. Other studies have demonstrated similar effects of flea control on several species of prairie dogs and, when combined with this study, suggest that the effects of enzootic plague are widespread. Finally, we demonstrated that the experimental F1-V fusion protein vaccine provides protection to ferrets in the wild. C1 [Matchett, Marc R.] US Fish & Wildlife Serv, Lewistown, MT 59457 USA. [Biggins, Dean E.] US Geol Survey, Ft Collins Sci Ctr, Ft Collins, CO USA. [Carlson, Valerie] Bur Land Management, Malta, MT USA. [Powell, Bradford] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. [Rocke, Tonie] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI USA. RP Matchett, MR (reprint author), US Fish & Wildlife Serv, POB 110,333 Airport Rd, Lewistown, MT 59457 USA. EM randy_matchett@fws.gov OI Rocke, Tonie/0000-0003-3933-1563 NR 34 TC 31 Z9 32 U1 5 U2 55 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 EI 1557-7759 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FEB PY 2010 VL 10 IS 1 SI SI BP 27 EP 35 DI 10.1089/vbz.2009.0053 PG 9 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 555PS UT WOS:000274526200005 PM 20158329 ER PT J AU Rocke, TE Pussini, N Smith, SR Williamson, J Powell, B Osorio, JE AF Rocke, Tonie E. Pussini, Nicola Smith, Susan R. Williamson, Judy Powell, Bradford Osorio, Jorge E. TI Consumption of Baits Containing Raccoon Pox-Based Plague Vaccines Protects Black-Tailed Prairie Dogs (Cynomys ludovicianus) SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Black-tailed prairie dogs; Cynomys ludovicianus; F1-V fusion protein; Oral vaccination; Plague; Raccoon poxvirus vaccines; Yersinia pestis ID F1-V FUSION PROTEIN; FERRETS MUSTELA-NIGRIPES; V-ANTIGEN PROTECTS; YERSINIA-PESTIS; PNEUMONIC PLAGUE; ORAL VACCINATION; FLEAS; MICE; CHALLENGE AB Baits containing recombinant raccoon poxvirus (RCN) expressing plague antigens ( fraction 1 [F1] and a truncated form of the V protein-V307) were offered for voluntary consumption several times over the course of several months to a group of 16 black-tailed prairie dogs (Cynomys ludovicianus). For comparison, another group of prairie dogs (n = 12) was injected subcutaneously (SC) ( prime and boost) with 40 mg of F1-V fusion protein absorbed to alum, a vaccine-adjuvant combination demonstrated to elicit immunity to plague in mice and other mammals. Control animals received baits containing RCN without the inserted antigen ( n 8) or injected diluent ( n 7), and as there was no difference in their survival rates by Kaplan-Meier analysis, all of them were combined into one group in the final analysis. Mean antibody titers to Yersinia pestis F1 and V antigen increased (p<0.05) in the vaccinated groups compared to controls, but titers were significantly higher (p<0.0001) in those receiving injections of F1-V fusion protein than in those orally vaccinated with RCN-based vaccine. Interestingly, upon challenge with approximately 70,000 cfu of virulent Y. pestis, oral vaccination resulted in survival rates that were significantly higher (p = 0.025) than the group vaccinated by injection with F1-V fusion protein and substantially higher (p<0.0001) than the control group. These results demonstrate that oral vaccination of prairie dogs using RCN-based plague vaccines provides significant protection against challenge at dosages that simulate simultaneous delivery of the plague bacterium by numerous flea bites. C1 [Rocke, Tonie E.; Pussini, Nicola; Smith, Susan R.; Williamson, Judy] USGS Natl Wildlife Hlth Ctr, Madison, WI 53711 USA. [Powell, Bradford] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. [Osorio, Jorge E.] Univ Wisconsin, Sch Vet Med, Madison, WI 53706 USA. RP Rocke, TE (reprint author), USGS Natl Wildlife Hlth Ctr, 6006 Schroeder Rd, Madison, WI 53711 USA. EM trocke@usgs.gov OI Rocke, Tonie/0000-0003-3933-1563 FU USGS-Biological Resources Division; Defense Advance Research Projects Agency; U.S. Army FX Technical and animal care assistance was provided by J. Lambert-Newman, L. Stickney, and S. Meier. Funding for this project was provided by the USGS-Biological Resources Division and the Defense Advance Research Projects Agency. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 23 TC 23 Z9 23 U1 4 U2 21 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FEB PY 2010 VL 10 IS 1 SI SI BP 53 EP 58 DI 10.1089/vbz.2009.0050 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 555PS UT WOS:000274526200008 PM 20158332 ER PT J AU Andrews, GP Vernati, G Ulrich, R Rocke, TE Edwards, WH Adamovicz, JJ AF Andrews, G. P. Vernati, G. Ulrich, R. Rocke, T. E. Edwards, W. H. Adamovicz, J. J. TI IDENTIFICATION AND CHARACTERIZATION OF IN VIVO-INDUCED CONSERVED SEQUENCES (IVICS) FROM YERSINIA PESTIS DURING INFECTION IN DIFFERENT SUSCEPTIBLE HOST SPECIES SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Meeting Abstract C1 [Andrews, G. P.; Vernati, G.] Univ Wyoming, Dept Vet Sci, Laramie, WY 82071 USA. [Ulrich, R.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. [Rocke, T. E.] US Geol Survey, Natl Wildlife Hlth Ctr, Madison, WI USA. [Edwards, W. H.] Wyoming State Game & Fish Dept, Laramie, WY USA. [Adamovicz, J. J.] Midwest Res Inst, Frederick, MD USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD FEB PY 2010 VL 10 IS 1 SI SI BP 94 EP 94 PG 1 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 555PS UT WOS:000274526200014 ER PT J AU Palazzo, DJ Lee, YJ Warnakulasooriya, R Pritchard, DE AF Palazzo, David J. Lee, Young-Jin Warnakulasooriya, Rasil Pritchard, David E. TI Patterns, correlates, and reduction of homework copying SO PHYSICAL REVIEW SPECIAL TOPICS-PHYSICS EDUCATION RESEARCH LA English DT Article ID MECHANICS AB Submissions to an online homework tutor were analyzed to determine whether they were copied. The fraction of copied submissions increased rapidly over the semester, as each weekly deadline approached and for problems later in each assignment. The majority of students, who copied less than 10% of their problems, worked steadily over the three days prior to the deadline, whereas repetitive copiers (those who copied >30% of their submitted problems) exerted little effort early. Importantly, copying homework problems that require an analytic answer correlates with a 2(sigma) decline over the semester in relative score for similar problems on exams but does not significantly correlate with the amount of conceptual learning as measured by pretesting and post-testing. An anonymous survey containing questions used in many previous studies of self-reported academic dishonesty showed similar to 1/3 less copying than actually was detected. The observed patterns of copying, free response questions on the survey, and interview data suggest that time pressure on students who do not start their homework in a timely fashion is the proximate cause of copying. Several measures of initial ability in math or physics correlated with copying weakly or not at all. Changes in course format and instructional practices that previous self-reported academic dishonesty surveys and/or the observed copying patterns suggested would reduce copying have been accompanied by more than a factor of 4 reduction of copying from similar to 11% of all electronic problems to less than 3%. As expected (since repetitive copiers have approximately three times the chance of failing), this was accompanied by a reduction in the overall course failure rate. Survey results indicate that students copy almost twice as much written homework as online homework and show that students nationally admit to more academic dishonesty than MIT students. C1 [Palazzo, David J.; Lee, Young-Jin; Warnakulasooriya, Rasil; Pritchard, David E.] MIT, Dept Phys, Cambridge, MA 02139 USA. [Palazzo, David J.] US Mil Acad, Dept Phys, West Point, NY 10996 USA. [Lee, Young-Jin] Univ Kansas, Dept Educ Leadership & Policy Studies, Lawrence, KS 66045 USA. [Warnakulasooriya, Rasil] Pearson Educ, Boston, MA 02116 USA. RP Palazzo, DJ (reprint author), MIT, Dept Phys, Cambridge, MA 02139 USA. FU MIT; NSF [0457451]; NIH [1-RC1-RR028302-01] FX We are grateful to A. Lipson for providing the 1992 freshman academic dishonesty data, to R. Romano for providing academic transcript data for the 2003-2005 8.01 students, to M. Jones and M. McGann for providing admission data for the 2003-2005 8.01 students, to D. McCabe for discussions, and to E. Hudson and P. Dourmashkin for using class time for our self-reporting surveys. This work was supported by MIT and the physics department in particular and by NSF (Grant No. 0457451) and NIH (Grant No. 1-RC1-RR028302-01). NR 16 TC 21 Z9 21 U1 1 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1554-9178 J9 PHYS REV SPEC TOP-PH JI Phys. Rev. Spec. Top.-Phys. Educ. R. PD JAN 27 PY 2010 VL 6 IS 1 AR 010104 DI 10.1103/PhysRevSTPER.6.010104 PG 11 WC Education & Educational Research; Education, Scientific Disciplines SC Education & Educational Research GA 603KS UT WOS:000278208100004 ER PT J AU Vyas, NK Nickitenko, A Rastogi, VK Shah, SS Quiocho, FA AF Vyas, Nand K. Nickitenko, Alexei Rastogi, Vipin K. Shah, Saumil S. Quiocho, Florante A. TI Structural Insights into the Dual Activities of the Nerve Agent Degrading Organophosphate Anhydrolase/Prolidase SO BIOCHEMISTRY LA English DT Article ID COLI AMINOPEPTIDASE-P; ESCHERICHIA-COLI; ACID ANHYDROLASE; BACTERIAL PHOSPHOTRIESTERASE; STEREOCHEMICAL SPECIFICITY; METHIONINE AMINOPEPTIDASE; PYROCOCCUS-FURIOSUS; NUCLEOTIDE-SEQUENCE; METAL CENTER; SUBSTRATE AB The organophosphate acid anhydrolase (OPAA) is a member of a class of bimetalloenzymes that hydrolyze a variety of toxic acetylcholinesterase-inhibiting organophosphorus compounds, including fluorine- chemical nerve agents. It also belongs to a family of prolidases, with significant activity against Various Xaa-Pro dipeptides. Here we report the X-ray Structure determination of the native OPAA (58 kDa mass) from Alteromonas sp. strain JD6.5 and its cocrystal with the inhibitor mipafox [N,N'-diisopropyldiamidofluorophosphate (DDFP)], a close analogue of the nerve agent organophosphate substrate diisopropyl fluorophosphate (DFP). The OPAA Structure is composed of two domains, amino and carboxy domains, with the latter exhibiting a "pita bread" architecture and harboring the active site with the binuclear Mn(2+) tons. The native OPAA structure revealed unexpectedly the presence of a well-defined nonproteinaceous density in the active site whose identity could not be definitively established but is suggestive of a bound glycolate, which is isosteric with a glycine (Xaa) product. All three glycolate oxygens coordinate the two Mn(2+) atoms. DDFP or more likely its hydrolysis product, N,N'-diisopropyldiamidophosphate (DDP), is present in the cocrystal structure and bound by coordinating the binuclear metals and forming hydrogen bonds and nonpolar interactions with active site residues. Ail Unusual common feature of the binding of the two ligands is the involvement of only one oxygen atom of the glycolate carboxylate and the product DDP tetrahedral phosphate in bridging the two Mn(2+) tons. Both Structures provide new understanding of ligand recognition and the prolidase and organophosphorus hydrolase catalytic activities of OPAA. C1 [Vyas, Nand K.; Nickitenko, Alexei; Quiocho, Florante A.] Baylor Coll Med, Verna & Marrs McLean Dept Biochem, Houston, TX 77030 USA. [Rastogi, Vipin K.; Shah, Saumil S.] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, BioDef Team, Aberdeen Proving Ground, MD 21010 USA. RP Quiocho, FA (reprint author), Baylor Coll Med, Verna & Marrs McLean Dept Biochem, Houston, TX 77030 USA. EM faq@bcm.tmc.edu FU U.S. Army-Edgewood Chemical Biological Center; Welch Foundation [Q-581] FX This work was supported by grants to F.A.Q. from the U.S. Army-Edgewood Chemical Biological Center and The Welch Foundation (Q-581). NR 51 TC 36 Z9 37 U1 1 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD JAN 26 PY 2010 VL 49 IS 3 BP 547 EP 559 DI 10.1021/bi9011989 PG 13 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 543YR UT WOS:000273618200017 PM 20000741 ER PT J AU Mulligan, CP Blanchet, TA Gall, D AF Mulligan, C. P. Blanchet, T. A. Gall, D. TI CrN-Ag nanocomposite coatings: Tribology at room temperature and during a temperature ramp SO SURFACE & COATINGS TECHNOLOGY LA English DT Article DE Nanocomposite coating; Friction; Wear; Solid lubrication; High-temperature lubrication; CrN-Ag ID SELF-LUBRICATING COATINGS; FRICTION; MODULUS; GROWTH; SILVER; FILMS; HARD; MICROSTRUCTURE; BEHAVIOR; LAYERS AB 5 mu m thick CrN-Ag composite layers with 22 at.% Ag were deposited by reactive magnetron co-sputtering on 440C stainless steel substrates. Increasing the growth temperature from T(s) = 500 to 600 to 700 degrees C leads to Ag segregation within the CrN matrix and the formation of embedded lamellar Ag aggregates with increasing Size, < 10(5), 9 X 10(6), and 7 x 10(7) nm(3), respectively. Ball-on-clisk tests against 100Cr6 steel, followed by optical profilometry and energy dispersive spectroscopy, indicate that the Ag grains for T(s) = 500 degrees C are too small to facilitate an effective lubricious surface layer, resulting in a friction coefficient mu = 0.58 and a composite coating wear rate of 3.8 x 10(-6) mm(3)/Nm that are nearly identical to those measured for pure CrN with mu = 0.64 and 3.6 x 10(-6) mm(3)/Nm. The T(s) = 600 degrees C coating exhibits a Ag concentration which is 15% higher within than outside the wear track, and acts as a lubricious layer that reduces mu to 0.47 and yields a 16x and 2.4x lower wear rate for coating and counterface, respectively. T(s) = 700 degrees C leads to a dramatic increase in surface roughness and an associated increase in friction, mu = 0.85, and wear, 9.9 x 10(-6) mm(3)/Nm. Replacing the steel counterface with an alumina ball results in the lowest mu = 0.50 for T(s) = 500 degrees C, attributed to the presence of Ag and the relatively low hardness of 16.5 GPa for this particular coating. In contrast, friction and wear increase dramatically for T(s) = 600 degrees C, which is attributed to a breakdown of the lubricious Ag layer by the harder counterface. The transient friction coefficient mu(t) during experiments with continuously increasing testing temperature T(t) = 25-700 degrees C initially decreases for all samples, attributed to drying of the environment and an effective softening of both coating and counterface. For the T(s) = 500 degrees C coating, a temperature activated solid lubricant transport yields a lubricious Ag surface layer and a very low mu(t) = 0.05 at T(t) similar to 500 degrees C. All coatings exhibit an increasing mu(t) for T(t) > 500 degrees C, which is attributed to oxidative degradation. Published by Elsevier B.V. C1 [Mulligan, C. P.; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. [Blanchet, T. A.] Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. [Mulligan, C. P.] USA, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA. RP Mulligan, CP (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA. EM c.mulligan@us.army.mil RI Gall, Daniel/B-1060-2008 OI Gall, Daniel/0000-0002-5762-9307 FU Armament Research, Development and Engineering Center (ARDEC); National Science Foundation [CMMI-0653843] FX This research was supported by the United States Army TEX3 Program, through the Armament Research, Development and Engineering Center (ARDEC), and by the National Science Foundation under grant no. CMMI-0653843. NR 33 TC 35 Z9 36 U1 6 U2 23 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD JAN 25 PY 2010 VL 204 IS 9-10 BP 1388 EP 1394 DI 10.1016/j.surfcoat.2009.09.018 PG 7 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 555GD UT WOS:000274495700011 ER PT J AU Daraio, JA Weber, LJ Newton, TJ Nestler, JM AF Daraio, Joseph A. Weber, Larry J. Newton, Teresa J. Nestler, John M. TI A methodological framework for integrating computational fluid dynamics and ecological models applied to juvenile freshwater mussel dispersal in the Upper Mississippi River SO ECOLOGICAL MODELLING LA English DT Article DE Ecohydraulics; Unionid; Integrated reference frameworks; CFD; Dispersal ID HYDRAULIC FLOW SIMULATION; AGENT METHOD ELAM; SETTLING VELOCITY; PARTICLE-TRACKING; FALL-VELOCITY; PHYSICAL HABITAT; CHESAPEAKE BAY; FISH PASSAGE; STOKES-LAW; TURBULENT AB Interdisciplinary research in hydraulics and ecology for river management and restoration must integrate processes that occur over a wide range of spatial and temporal scales, which presents a challenge to ecohydraulics modelers. Computational fluid dynamics (CFD) models are being more widely used to determine flow fields for ecohydraulics applications. In the Upper Mississippi River (UMR), the mussel dynamics model was developed as a tool for management and conservation of freshwater mussels (Unionidae), which are benthic organisms, imperiled in North America, that are inextricably linked with the hydraulics of river flow. We updated the juvenile dispersal component of the mussel dynamics model by using stochastic Lagrangian particle tracking in a three dimensional flow field output from CFD models of reaches in the UMR. We developed a methodological framework to integrate hydrodynamic data with the mussel dynamics model, and we demonstrate the use of the juvenile dispersal model employed within the methodological framework in two reaches of the UMR. The method was used to test the hypothesis that impoundment affects the relationship of some hydraulic parameters with juvenile settling distribution. Simulation results were consistent with this hypothesis, and the relationships of bed shear stress and Froude number with juvenile settling were altered by impoundment most likely through effects on local hydraulics. The methodological framework is robust, integrates Eulerian and Lagrangian reference frameworks, and incorporates processes over a wide range of temporal and spatial scales, from watershed scale hydrologic processes (decades), to reach scale (km) processes that occur over hours or days, and turbulent processes on spatial scales of meter to millimeter and times scales of seconds. The methods are presently being used to assess the impacts of pre- and early post-settlement processes on mussel distributions, including the effects of bed shear stress, and the sensitivity of the location of the host fish when juveniles excyst, on juvenile settling distribution. (C) 2009 Elsevier B.V. All rights reserved. C1 [Daraio, Joseph A.; Weber, Larry J.] Univ Iowa, IIHR Hydrosci & Engn, Maxwell Stanley Hydraul Lab 100C, Iowa City, IA 52242 USA. [Newton, Teresa J.] Upper Midwest Environm Sci Ctr, USGS, La Crosse, WI 54603 USA. [Nestler, John M.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Daraio, JA (reprint author), Tennessee Technol Univ, Ctr Management Utilizat & Protect Water Resources, Cookeville, TN 38505 USA. EM joseph.a.daraio@gmail.com OI Daraio, Joe/0000-0001-5591-4465; Newton, Teresa/0000-0001-9351-5852 FU IIHR Hydroscience and Engineering FX This research was funded by IIHR Hydroscience and Engineering. The authors would like to thank George Constantinescu, Mark Ecker, Keri Hornbuckle, Brian Ickes, Jeff Steuer, and Steve Zigler for valuable input over the course of this research. Our work would not have been possible without the previous efforts of Andy McCoy, Yenory Morales, and Nate Young. We also thank Yenory and three anonymous reviewers for constructive criticism and comments on the manuscript. Product names are provided for informational purposes only and do not represent an endorsement by the U.S. Geological Survey. NR 88 TC 19 Z9 20 U1 2 U2 28 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD JAN 24 PY 2010 VL 221 IS 2 BP 201 EP 214 DI 10.1016/j.ecolmodel.2009.10.008 PG 14 WC Ecology SC Environmental Sciences & Ecology GA 544CF UT WOS:000273628800009 ER PT J AU Cohen, SP Brown, C Kurihara, C Plunkett, A Nguyen, C Strassels, SA AF Cohen, Steven P. Brown, Charlie Kurihara, Connie Plunkett, Anthony Nguyen, Conner Strassels, Scott A. TI Diagnoses and factors associated with medical evacuation and return to duty for service members participating in Operation Iraqi Freedom or Operation Enduring Freedom: a prospective cohort study SO LANCET LA English DT Article ID LOW-BACK-PAIN; NECK PAIN; GULF-WAR; MILITARY; MANAGEMENT; CASUALTIES; DISORDERS; INJURY AB Background Anticipation of the types of injuries that occur in modem warfare is essential to plan operations and maintain a healthy military. We aimed to identify the diagnoses that result in most medical evacuations, and ascertain which demographic and clinical variables were associated with return to duty. Methods Demographic and clinical data were prospectively obtained for US military personnel who had been medically evacuated from Operation Iraqi Freedom or Operation Enduring Freedom (January, 2004-December, 2007). Diagnoses were categorised post hoc according to the International Classification of Diseases codes that were recorded at the time of transfer. The primary outcome measure was return to duty within 2 weeks. Findings 34006 personnel were medically evacuated, of whom 89% were men, 91% were enlisted, 82% were in the army, and 86% sustained an injury in Iraq. The most common reasons for medical evacuation were: musculoskeletal and connective tissue disorders (n=8104 service members, 24%), combat injuries (n=4713, 14%), neurological disorders (n=3502, 10%), psychiatric diagnoses (n=3108, 9%), and spinal pain (n=2445, 7%). The factors most strongly associated with return to duty were being a senior officer (adjusted OR 2.01, 95% Cl 1.71-2.35, p<0.0001), having a non-battle-related injury or disease (3.18, 2.77-3.67, p<0.0001), and presenting with chest or abdominal pain (2.48, 1.61-3.81, p<0.0001), a gastrointestinal disorder (non-surgical 2.32, 1.51-3.56, p=0.0001; surgical 2.62, 1.69-4.06, p<0.0001), or a genitourinary disorder (2.19, 1.43-3.36, p=0.0003). Covariates associated with a decreased probability of return to duty were serving in the navy or coast guard (0.59, 0.45-0.78, p=0.0002), or marines (0.86,0.77-0.96, p=0.0083); and presenting with a combat injury (0.27, 0.17-0.44, p<0.0001), a psychiatric disorder (0.28, 0.18-0.43, p<0.0001), musculoskeletal or connective tissue disorder (0.46, 0.30-0.71, p=0.0004), spinal pain (0.41, 0.26-0.63, p=0.0001), or other wound (0.54, 0.34-0.84, p=0.0069). Interpretation Implementation of preventive measures for service members who are at highest risk of evacuation, forward-deployed treatment, and therapeutic interventions could reduce the effect of non-battle-related injuries and disease on military readiness. C1 [Cohen, Steven P.] Johns Hopkins Sch Med, Pain Management Div, Baltimore, MD USA. [Brown, Charlie] Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA. [Cohen, Steven P.; Kurihara, Connie; Plunkett, Anthony] Walter Reed Army Med Ctr, Pain Management Div, Anesthesia Serv, Dept Surg, Washington, DC 20307 USA. [Nguyen, Conner] Landstuhl Reg Med Ctr, Dept Surg, Landstuhl, Germany. [Strassels, Scott A.] Univ Texas Austin, Div Pharm Practice, Austin, TX 78712 USA. RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P Murtha Neuroscience and Pain Institute, Johnstown, PA, USA; US Army Regional Anesthesia and Pain Management Initiative, Washington, DC, USA FX Funded by a Congressional grant from the John P Murtha Neuroscience and Pain Institute, Johnstown, PA, USA; and the US Army Regional Anesthesia and Pain Management Initiative, Washington, DC, USA. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense. NR 24 TC 74 Z9 76 U1 1 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0140-6736 J9 LANCET JI Lancet PD JAN 23 PY 2010 VL 375 IS 9711 BP 301 EP 309 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA 549QS UT WOS:000274069300031 PM 20109957 ER PT J AU Kohl, A Cochran, J Cropek, DM AF Kohl, Anja Cochran, Jack Cropek, Donald M. TI Characterization of military fog oil by comprehensive two-dimensional gas chromatography SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article DE GCxGC-FID; GCxGC-TOFMS; Military fog oil; Inverse column set; Shape selective column; Silica gel fractionation ID DIAMONDOID HYDROCARBON RATIOS; CRUDE OILS; X GC; PETROLEUM; IDENTIFICATION; SEDIMENTS; TOXICITY; BITUMEN; HOPANES; COLUMN AB The most commonly used military fog oil is characterized by comprehensive two-dimensional gas chromatography (GCxGC) coupled to either Flame Ionization Detection (FID) or Time-of-Flight Mass Spectrometric Detection (TOFMS) to advance the knowledge regarding the complete chemical makeup of this complex matrix. Two different GCxGC column sets were investigated, one employing a non-polar column combined with a shape selective column and the other an inverse column set (medium-polar/non-polar). The inverse set maximizes the use of the two-dimensional separation space and segregates aliphatic from aromatic fractions. The shape selective column best separates individual polycyclic aromatic hydrocarbons (PAHs) from the bulk oil. The results reveal that fog oil (FO) is composed mainly of aliphatic compounds ranging from C(10) to C(30), where naphthenes comprise the major fraction. Although many different species of aromatics are present, they constitute only a minor fraction in this oil, and no conjugated PAHs are found. The composition of chemically similar aliphatic constituents limits the analytical power of silica gel fractionation and GC-MS analysis to characterize FO. Among the aliphatic compounds identified are alkanes, cyclohexanes, hexahydroindanes, decalins, adamantanes, and bicyclohexane. The aromatic fraction is composed of alkylbenzene compounds, indanes, tetrahydronaphthalenes, partially hydrogenated PAHs, biphenyls, dibenzofurans and dibenzothiophenes. This work represents the best characterization of military fog oil to date. As the characterization process shows, information on such complex samples can only be parsed using a combination of sample preprocessing steps, multiple detection schemes, and an intelligent selection of column chemistries. Published by Elsevier B.V. C1 [Kohl, Anja; Cropek, Donald M.] USA, Corps Engineers, Construct Engn Res Lab, Champaign, IL 61822 USA. [Cochran, Jack] Restek Corp, Bellefonte, PA 16823 USA. RP Cropek, DM (reprint author), USA, Corps Engineers, Construct Engn Res Lab, 2902 Newmark Dr, Champaign, IL 61822 USA. EM Donald.M.Cropek@usace.army.mil FU U.S. Army Strategic Environmental Research and Development; Student Research Participation Program; U.S. Department of Energy; ERDC-CERL FX The authors wish to acknowledge LECO Corporation for the use of the GCxGC-TOFMS instrument and are grateful for the loan of the RSSC column from Frank Dorman and Mike Wittrig of Restek Corporation. Funding for this project from the U.S. Army Strategic Environmental Research and Development Program is greatly appreciated. This research was supported, in part, by an appointment to the Student Research Participation Program at the U.S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory, administered by the Oak Ridge Institute for Science and Education through an interagency agreement between the U.S. Department of Energy and ERDC-CERL. NR 30 TC 14 Z9 14 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD JAN 22 PY 2010 VL 1217 IS 4 BP 550 EP 557 DI 10.1016/j.chroma.2009.11.054 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 555AN UT WOS:000274479200015 PM 19963218 ER PT J AU Little, SF Webster, WM Wilhelm, H Fisher, D Norris, SLW Powell, BS Enama, J Adamovicz, JJ AF Little, S. F. Webster, W. M. Wilhelm, H. Fisher, D. Norris, S. L. W. Powell, B. S. Enama, J. Adamovicz, J. J. TI Quantitative anti-F1 and anti-V IgG ELISAs as serological correlates of protection against plague in female Swiss Webster mice SO VACCINE LA English DT Article DE Yersinia pestis; Plague; F1-V vaccine; Mice; Serological correlate ID EXPERIMENTAL PNEUMONIC PLAGUE; YERSINIA OUTER PROTEINS; BUBONIC PLAGUE; IMMUNE-RESPONSE; SUBUNIT VACCINE; FUSION PEPTIDE; ACTIVE IMMUNIZATION; PASTEURELLA-PESTIS; PASSIVE-IMMUNITY; YOP SECRETION AB A recombinant fusion protein composed of Yersinia pestis fraction I capsule (F1) and virulence-associated V antigen (V) (F1-V) has been developed as the next-generation vaccine against plague In this study, female Swiss Webster mice received a single intramuscular vaccination with one of eight doses of the F1-V vaccine and exposed 4 weeks later, to either Y pestis CO92 or C12 organisms by the subcutaneous or aerosol routes of infection Quantitative anti-F1 and anti-V immunoglobulin G (IgG) ELISAs were used to examine the relationship between survival outcome and antibody titers to F1 and V. Results suggested that each 1 log(10) increase in week 4 quantitative anti-F1 and anti-V IgG ELISA titers were associated with a I 7-fold (p = 0 0051) and 2 5-fold (p = 0 0054) increase in odds of survival, respectively. against either bubonic or pneumonic plague and may serve as serological correlates of protection Published by Elsevier Ltd C1 [Little, S. F.; Webster, W. M.; Wilhelm, H.; Powell, B. S.; Enama, J.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD 21702 USA. [Fisher, D.; Norris, S. L. W.] USA, Med Res Inst Infect Dis, Biostat Serv Div, Frederick, MD 21702 USA. [Adamovicz, J. J.] Midwest Res Inst, Frederick, MD 21702 USA. RP Little, SF (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Frederick, MD 21702 USA. NR 59 TC 4 Z9 5 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 22 PY 2010 VL 28 IS 4 BP 934 EP 939 DI 10.1016/j.vaccine.2009.10.143 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 560ZB UT WOS:000274943300015 PM 19925906 ER PT J AU Martin, SS Bakken, RR Lind, CM Garcia, P Jenkins, E Glass, PJ Parker, MD Hart, MK Fine, DL AF Martin, Shannon S. Bakken, Russell R. Lind, Cathleen M. Garcia, Patricia Jenkins, Erin Glass, Pamela J. Parker, Michael D. Hart, Mary Kate Fine, Donald L. TI Comparison of the immunological responses and efficacy of gamma-irradiated V3526 vaccine formulations against subcutaneous and aerosol challenge with Venezuelan equine encephalitis virus subtype IAB SO VACCINE LA English DT Article DE Venezuelan equine encephalitis virus (VEEV); Adjuvants; Gamma-irradiated vaccines ID ENCEPHALOMYELITIS VIRUS; IMMUNE-RESPONSES; CPG OLIGODEOXYNUCLEOTIDES; MALARIA VACCINE; SAFETY; IMMUNOGENICITY; PROTECTION; INFECTION; RADIATION; CPG-7909 AB We recently developed a gamma-irradiation method to inactivate V3526. a live-attenuated Venezuelan equine encephalitis virus (VEEV) vaccine candidate Dosage and schedule Studies were conducted to evaluate the immunogenicity and efficacy of gamma-irradiated V3526 (gV3526) Subcutaneous (SC) and low dosage Intramuscular (IM) administration of gV3526 were highly effective in protecting mice against a SC challenge with VEEV IA/B Trinidad Donkey strain. but not against an equivalent aerosol challenge More robust immune responses and increased protective efficacy were noted when the IM dosage of gV3526 was increased. IM administration of gV3526 formulated with either CpG or CpG plus Alhydrogel (TM) further augmented the Immune response in mice and resulted in 100% protection against aerosol challenge (C) 2009 Elsevier Ltd All rights reserved. C1 [Martin, Shannon S.; Jenkins, Erin; Hart, Mary Kate; Fine, Donald L.] CSC Co, DynPort Vaccine Co LLC, Frederick, MD 21702 USA. [Bakken, Russell R.; Lind, Cathleen M.; Garcia, Patricia; Glass, Pamela J.; Parker, Michael D.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Martin, SS (reprint author), CSC Co, DynPort Vaccine Co LLC, 64 Thomas Johnson Dr, Frederick, MD 21702 USA. RI Glass, Pamela/G-1170-2011 FU National Institute of Allergy and Infectious Diseases [1UC1AI062538-01]; Joint Science and Technology Office-Chemical, Biological Defense [Plan1.1C0041_09_RD_B] FX The research described herein was sponsored by the National Institute of Allergy and Infectious Diseases grant number 1UC1AI062538-01 and the Joint Science and Technology Office-Chemical, Biological Defense Plan1.1C0041_09_RD_B. NR 46 TC 16 Z9 16 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 22 PY 2010 VL 28 IS 4 BP 1031 EP 1040 DI 10.1016/j.vaccine.2009.10.126 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 560ZB UT WOS:000274943300028 PM 19914193 ER PT J AU Livingston, BD Little, SF Luxembourg, A Ellefsen, B Hannaman, D AF Livingston, Brian D. Little, Stephen F. Luxembourg, Alain Ellefsen, Barry Hannaman, Drew TI Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques SO VACCINE LA English DT Article DE DNA vaccine; Electroporation; Immunology ID RECOMBINANT PROTECTIVE ANTIGEN; IN-VIVO ELECTROPORATION; IMMUNE-RESPONSES; BACILLUS-ANTHRACIS; ANTIBODY-RESPONSE; HEALTHY-ADULTS; LETHAL FACTOR; DOUBLE-BLIND; IMMUNOGENICITY; SAFETY AB DNA vaccination is a promising immunization Strategy that could be applied in the development of vaccines for a variety of prophylactic and therapeutic indications Utilizing anthrax protective antigen as a model antigen, we demonstrate that electroporation mediated delivery enhanced the immunogenicity of DNA vaccines in nonhuman primates over 100-fold as compared to conventional intramuscular injection Two administrations of a DNA vaccine with electroporation elicited anthrax toxin neutralizing antibody responses in 100% of rhesus macaques Toxin neutralizing antibodies were sustained for the nearly I year study duration and were correlated with protection against subsequent lethal Bacillus anthracis spore challenge. Collectively, electroporation mediated DNA vaccination conferred protection comparable to that observed following vaccination with an FDA approved anthrax vaccine (C) 2009 Elsevier Ltd All rights reserved C1 [Livingston, Brian D.; Luxembourg, Alain; Ellefsen, Barry; Hannaman, Drew] Ichor Med Syst, San Diego, CA 92121 USA. [Little, Stephen F.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Livingston, BD (reprint author), Ichor Med Syst, 6310 Nancy Ridge Dr,Suite 107, San Diego, CA 92121 USA. FU NIH SBIR [AI052670] FX The authors would like to thank Drs. Edwin Ades (CDC), Stanley Goldman (NMRC) and Peter Hobart (USAMRIID) for helpful discussions, we would also like to thank USAMMA for providing the Biothrax utilized in this study. This study was funded by a NIH SBIR grant (#AI052670). NR 50 TC 38 Z9 38 U1 1 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 22 PY 2010 VL 28 IS 4 BP 1056 EP 1061 DI 10.1016/j.vaccine.2009.10.111 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 560ZB UT WOS:000274943300031 PM 19896452 ER PT J AU Colacicco-Mayhugh, MG Masuoka, PM Grieco, JP AF Colacicco-Mayhugh, Michelle G. Masuoka, Penny M. Grieco, John P. TI Ecological niche model of Phlebotomus alexandri and P. papatasi (Diptera: Psychodidae) in the Middle East SO INTERNATIONAL JOURNAL OF HEALTH GEOGRAPHICS LA English DT Article ID CUTANEOUS LEISHMANIASIS; SAND FLIES; GEOGRAPHIC DISTRIBUTIONS; VISCERAL LEISHMANIASIS; SPECIES DISTRIBUTIONS; VECTOR; POPULATIONS; BRAZIL; FOCUS; DYNAMICS AB Background: The purpose of this study is to create distribution models of two sand fly species, Phlebotomus papatasi (Scopoli) and P. alexandri (Sinton), across the Middle East. Phlebotomus alexandri is a vector of visceral leishmaniasis, while P. papatasi is a vector of cutaneous leishmaniasis and sand fly fever. Collection records were obtained from literature reports from 1950 through 2007 and unpublished field collection records. Environmental layers considered in the model were elevation, precipitation, land cover, and WorldClim bioclimatic variables. Models were evaluated using the threshold-independent area under the curve (AUC) receiver operating characteristic analysis and the threshold-dependent minimum training presence. Results: For both species, land cover was the most influential environmental layer in model development. The bioclimatic and elevation variables all contributed to model development; however, none influenced the model as strongly as land cover. Conclusion: While not perfect representations of the absolute distribution of P. papatasi and P. alexandri, these models indicate areas with a higher probability of presence of these species. This information could be used to help guide future research efforts into the ecology of these species and epidemiology of the pathogens that they transmit. C1 [Colacicco-Mayhugh, Michelle G.] Walter Reed Army Inst Res, Dept Sand Fly Biol, Div Entomol, Silver Spring, MD 20910 USA. [Masuoka, Penny M.; Grieco, John P.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP Colacicco-Mayhugh, MG (reprint author), Walter Reed Army Inst Res, Dept Sand Fly Biol, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM michelle.colacicco@us.army.mil NR 34 TC 24 Z9 26 U1 0 U2 5 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1476-072X J9 INT J HEALTH GEOGR JI Int. J. Health Geogr. PD JAN 21 PY 2010 VL 9 AR 2 DI 10.1186/1476-072X-9-2 PG 9 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 558XN UT WOS:000274782300001 PM 20089198 ER PT J AU Simeon, T Balasubramanian, K Welch, CR AF Simeon, Tomekia Balasubramanian, Krishnan Welch, Charles R. TI Theoretical Study of the Interactions of In+ and In3+ with Stone-Wales Defect Single-Walled Carbon Nanotubes SO JOURNAL OF PHYSICAL CHEMISTRY LETTERS LA English DT Article ID RELATIVISTIC EFFECTIVE POTENTIALS; SPIN-ORBIT OPERATORS; ADSORPTION; GRAPHENE; METALS AB We have performed a density functional study on the binding of indium ions (In and In3+) to the surface of pristine and defective armchair single wall carbon nanotubes (SWNT). Among the various structural isomers that are studied the position above the hexagon is found to be the most stable site for absorption, while the binding is enhanced in the defective SWNT compared to that in the pristine SWNT. The computed Mulliken charges, HOMO-LUMO gap energies, interactions and interaction energies of the systems reveal fascinating electronic charge delocalization on phenomena explaining the observed electromigration. C1 [Balasubramanian, Krishnan] Calif State Univ Hayward, Dept Math & Comp Sci, Hayward, CA 94542 USA. [Simeon, Tomekia] Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Balasubramanian, Krishnan] Lawrence Livermore Natl Lab, Chem & Mat Sci Directorate, Livermore, CA 94550 USA. [Balasubramanian, Krishnan] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA. [Welch, Charles R.] USA, Informat Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Balasubramanian, K (reprint author), Calif State Univ Hayward, Dept Math & Comp Sci, Hayward, CA 94542 USA. EM balu@llnl.gov FU U.S. Army Engineer Research and Development Center [W912HZ-05-D-0012]; High Performance Computational Design of Novel Materials; U.S. Department of Defense High Performance Computing Modernization Office; U.S. Department of Energy [DE-FG2-05ER15657, W-7405-Eng-48] FX This work was supported in part by the U.S. Army Engineer Research and Development Center under Contract W912HZ-05-D-0012, "High Performance Computational Design of Novel Materials", and by the U.S. Department of Defense High Performance Computing Modernization Office. This work at Cal State was supported by the U.S. Department of Energy under Grant No. DE-FG2-05ER15657. The work at LLNL was performed under the auspices of the U.S. Department of Energy under Contract No. W-7405-Eng-48. NR 35 TC 6 Z9 6 U1 1 U2 15 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1948-7185 J9 J PHYS CHEM LETT JI J. Phys. Chem. Lett. PD JAN 21 PY 2010 VL 1 IS 2 BP 457 EP 462 DI 10.1021/jz900125e PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Atomic, Molecular & Chemical SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 588BC UT WOS:000277040000001 ER PT J AU Carrieri, AH Copper, J Owens, DJ Roese, ES Bottiger, JR Everly, RD Hung, KC AF Carrieri, Arthur H. Copper, Jack Owens, David J. Roese, Erik S. Bottiger, Jerold R. Everly, Robert D., II Hung, Kevin C. TI Infrared differential-absorption Mueller matrix spectroscopy and neural network-based data fusion for biological aerosol standoff detection SO APPLIED OPTICS LA English DT Article ID CHEMICAL WARFARE AGENTS; EXPOSURE AB An active spectrophotopolarimeter sensor and support system were developed for a military/civilian defense feasibility study concerning the identification and standoff detection of biological aerosols. Plumes of warfare agent surrogates gamma-irradiated Bacillus subtilis and chicken egg white albumen (analytes), Arizona road dust (terrestrial interferent), water mist (atmospheric interferent), and talcum powders ( experiment controls) were dispersed inside windowless chambers and interrogated by multiple CO2 laser beams spanning 9.1-12.0 mu m wavelengths (lambda). Molecular vibration and vibration-rotation activities by the subject analyte are fundamentally strong within this "fingerprint" middle infrared spectral region. Distinct polarization-modulations of incident irradiance and backscatter radiance of tuned beams generate the Mueller matrix (M) of subject aerosol. Strings of all 15 normalized elements {M-ij(lambda)/M-11(lambda)}, which completely describe physical and geometric attributes of the aerosol particles, are input fields for training hybrid Kohonen self-organizing map feed-forward artificial neural networks (ANNs). The properly trained and validated ANN model performs pattern recognition and type-classification tasks via internal mappings. A typical ANN that mathematically clusters analyte, interferent, and control aerosols with nil overlap of species is illustrated, including sensitivity analysis of performance. (C) 2010 Optical Society of America C1 [Carrieri, Arthur H.; Roese, Erik S.; Bottiger, Jerold R.] USA, RDECOM, ECBC, Res & Technol Directorate,Attent RDCB DRD L, Aberdeen Proving Ground, MD 21010 USA. [Owens, David J.] Quetron Syst Inc, Forest Hill, MD 21050 USA. [Hung, Kevin C.] Adv Technol & Applicat Inc, Attent RDCB DRD L, Aberdeen Proving Ground, MD 21010 USA. RP Carrieri, AH (reprint author), USA, RDECOM, ECBC, Res & Technol Directorate,Attent RDCB DRD L, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM arthur.carrieri@us.army.mil NR 19 TC 6 Z9 7 U1 1 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JAN 20 PY 2010 VL 49 IS 3 BP 382 EP 393 DI 10.1364/AO.49.000382 PG 12 WC Optics SC Optics GA 547II UT WOS:000273880200014 PM 20090802 ER PT J AU Maier, RS Bernard, RS AF Maier, R. S. Bernard, R. S. TI Lattice-Boltzmann accuracy in pore-scale flow simulation SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article DE Porous media; Pore-scale simulation; Lattice-Boltzmann; Boundary condition ID BOUNDARY-CONDITIONS; POROUS-MEDIA; STOKES EQUATIONS; SPHERES; DISPERSION; ARRAYS; FLUID; BGK; PACKINGS; SCHEMES AB We investigate the possibility of using nominally second-order-accurate techniques for resolving flow about solid boundaries as a means of improving accuracy and reducing grid resolution requirements in pore-scale simulations. An LBGK method is used to calculate flow in several geometries of increasing complexity, using a first-order accurate and two nominally second-order-accurate methods for no-slip boundaries. The geometries include uniform flow past an isolated sphere, quadratic flow past a sphere near a wall, flow through a BCC array of spheres, and through a randomly packed bed of spheres. The packed bed flows are also used to compare hydrodynamic dispersion results. The results confirm second-order-accurate behavior where Navier-Stokes flows are clearly developed. However 3D pore-scale simulations involve a trade-off between resolution of the flow and the number of pore spaces, and there is a resolution threshold, below which certain flow features, such as recirculation, are not resolved. We conjecture that most simulations will tend to operate near this threshold because of the competing demands for resolution and statistical accuracy. We consider local flow features and the velocity distribution, in addition to hydraulic permeability and drag, to provide a fuller understanding of accuracy near this threshold. Published by Elsevier Inc. C1 [Maier, R. S.; Bernard, R. S.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Maier, RS (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM robert.s.maier@usace.army.mil NR 55 TC 26 Z9 26 U1 0 U2 20 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 J9 J COMPUT PHYS JI J. Comput. Phys. PD JAN 20 PY 2010 VL 229 IS 2 BP 233 EP 255 DI 10.1016/j.jcp.2009.09.013 PG 23 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA 532OY UT WOS:000272760500002 ER PT J AU Simmons, M Burgess, T Lynch, J Putnak, R AF Simmons, Monika Burgess, Timothy Lynch, Julia Putnak, Robert TI Protection against dengue virus by non-replicating and live attenuated vaccines used together in a prime boost vaccination strategy SO VIROLOGY LA English DT Article DE Dengue DNA; Purified inactivated virus; Live attenuated virus; Prime boost ID TYPE-2 DNA VACCINE; ANTIBODY-RESPONSES; INCREASES IMMUNOGENICITY; NEUTRALIZING ANTIBODIES; RECOMBINANT SUBUNIT; RHESUS-MONKEYS; CLINICAL-TRIAL; NAIVE ADULTS; GM-CSF; VOLUNTEERS AB A new vaccination strategy for dengue virus (DENV) was evaluated in rhesus macaques by priming with tetravalent purified inactivated virus (TPIV) or tetravalent plasmid DNA vaccines expressing the structural prME gene region (TDNA) then boosting 2 months later with a tetravalent live attenuated virus (TLAV) vaccine. Both vaccine combinations elicited virus neutralizing (N) antibodies. The TPIV/TLAV combination afforded complete protection against DENV 3 challenge at month 8. In a second experiment, priming with TPIV elicited N antibodies against all four serotypes (GMT 1:28 to 1:43). Boosting with TLAV led to an increase in the GMT for each serotype (1:500 to 1:1200 for DENVs 1, 3, and 4, and greater than 1:6000 for DENV 2), which declined by month 8 (GMT 1:62 for DENV 3,1:154 for DENV 1, 1:174 for DENV 4, and 1:767 for DENV 2). After challenge with each one of the four DENV serotypes, vaccinated animals exhibited no viremia but showed anamnestic antibody responses to the challenge viruses. Published by Elsevier Inc. C1 [Simmons, Monika; Burgess, Timothy] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. [Lynch, Julia; Putnak, Robert] Walter Reed Army Inst Res, Div Viral Dis, Silver Spring, MD 20910 USA. RP Simmons, M (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA. EM monika.simmons@med.navy.mil; timothy.burgess2@med.navy.mil; julia.lynchc@us.army.mil; joseph.robert.putnak@us.army.mil FU Naval Medical Research Center [6000.RAD1.S.A0312]; U.S. Army Medical Research and Materiel Command FX This research was supported by Naval Medical Research Center work unit # 6000.RAD1.S.A0312 and the U.S. Army Medical Research and Materiel Command. NR 32 TC 41 Z9 44 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JAN 20 PY 2010 VL 396 IS 2 BP 280 EP 288 DI 10.1016/j.virol.2009.10.023 PG 9 WC Virology SC Virology GA 542OS UT WOS:000273504600012 PM 19913867 ER PT J AU Arnett, CM Marsh, CP Welch, CR Strano, MS Han, JH Gray, JH Carlson, TA AF Arnett, Clint M. Marsh, Charles P. Welch, Charles R. Strano, Michael S. Han, Jae-Hee Gray, Jeffry H. Carlson, Thomas A. TI Enzyme-Mediated Assimilation of DNA-Functionalized Single-Walled Carbon Nanotubes SO LANGMUIR LA English DT Article ID CHROMATOGRAPHY; DISPERSION AB When pyrimidine-functionalized carbon nanotubes were incubated with single-stranded DNA ligase, formations of macroscopic aggregates were observed. Wet-cell transmission electron microscopy imaging revealed that the nanotubes were radially bound to form a 3D latticelike structure. These structures were not observed in control reactions lacking ligase or adenosine triphosphate. Raman spectroscopy analysis revealed no spectra indicative of carbon nanotubes in ligase-unamended controls; however, spectra were observed in radial breathing mode and in the G and G' bands in reactions containing ligase. Furthermore, the addition of deoxyribonuclease to the ligated reactions dispersed the aggregates, and a reduction in Raman spectral intensity was observed. C1 [Arnett, Clint M.; Marsh, Charles P.; Gray, Jeffry H.; Carlson, Thomas A.] USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Marsh, Charles P.] Univ Illinois, Dept Nucl Plasma & Radiol Engn, Urbana, IL 61801 USA. [Welch, Charles R.] USA, Engn Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. [Strano, Michael S.; Han, Jae-Hee] MIT, Dept Chem Engn, Cambridge, MA 02139 USA. RP Arnett, CM (reprint author), USA, Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. EM clint.arnett@usace.army.mil RI Zhou, Charlie/N-5376-2015 FU Oak Ridge Institute for Science and Education; U.S. Department of Energy; U.S. Army Construction Engineering Research Laboratory FX This research was supported in part by appointments at the Research Participation Program administered by the Oak Ridge Institute for Science and Education through a cooperative agreement between the U.S. Department of Energy and the U.S. Army Construction Engineering Research Laboratory. We thank the Frederick Seitz Materials Research Laboratory located at the University of Illinois for the use of their TEM facilities. Although this research was conducted at the U.S. Army Engineer Research and Development Center, it has not been subjected to Army review and therefore no official endorsement should be inferred. NR 20 TC 8 Z9 8 U1 3 U2 12 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JAN 19 PY 2010 VL 26 IS 2 BP 613 EP 617 DI 10.1021/la902564n PG 5 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 541GN UT WOS:000273403400001 PM 19957946 ER PT J AU Chen, Q Mogilevsky, G Wagner, GW Forstater, J Kleinhammes, A Wu, Y AF Chen, Qiang Mogilevsky, Gregory Wagner, George W. Forstater, Jacob Kleinhammes, Alfred Wu, Yue TI Active anatase (0 0 1)-like surface of hydrothermally synthesized titania nanotubes (vol 482, pg 134, 2009) SO CHEMICAL PHYSICS LETTERS LA English DT Correction C1 [Chen, Qiang; Mogilevsky, Gregory; Forstater, Jacob; Kleinhammes, Alfred; Wu, Yue] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. [Chen, Qiang; Mogilevsky, Gregory; Forstater, Jacob; Kleinhammes, Alfred; Wu, Yue] Univ N Carolina, Curriculum Appl & Mat Sci, Chapel Hill, NC 27599 USA. [Wagner, George W.] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Wu, Y (reprint author), Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA. EM yuewu@physics.unc.edu NR 1 TC 1 Z9 1 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD JAN 18 PY 2010 VL 485 IS 1-3 BP 262 EP 262 DI 10.1016/j.cplett.2009.11.011 PG 1 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 539CV UT WOS:000273231900053 ER PT J AU Rowe, B Schmidt, JJ Smith, LA Ahmed, SA AF Rowe, Benjamin Schmidt, James J. Smith, Leonard A. Ahmed, S. Ashraf TI Rapid product analysis and increased sensitivity for quantitative determinations of botulinum neurotoxin proteolytic activity SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE HPLC; UPLC; Botulinum neurotoxin; Protease; Product analysis ID LASER-INDUCED FLUORESCENCE; LIGHT-CHAIN; SEROTYPE-A; SUBSTRATE RECOGNITION; PROTEASE ACTIVITIES; CATALYTIC-ACTIVITY; MEMBRANE-PROTEIN; TOXIN; CLEAVAGE; IDENTIFICATION AB The ultimate molecular action of botulinum neurotoxin (BoNT) is a Zn-dependent endoproteolytic activity on one of the three SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins. There are seven serotypes (A-G) of BoNT having distinct cleavage sites on the SNARE substrates. The proteolytic activity is located on the N-terminal light chain (Lc) domain and is used extensively as the primary target toward therapeutic development against botulism. Here we describe an improved method using ultra-performance liquid chromatography (UPLC) whereby quantitative data were obtained in 1/10th the time using 1/20th the sample and solvent volumes compared with a widely used high-performance liquid chromatography (HPLC) method. We also synthesized a VAMP (vesicle-associated membrane protein)-based peptide containing an intact V1 motif that was efficiently used as a substrate by BoNT/D Lc. Although serotype C1 cleaves the serotype A substrate at a bond separated by only one residue, we were able to distinguish the two reactions by UPLC. The new method can accurately quantify as low as 7 pmol of the peptide substrates for BoNT serotypes A, B. Cl, and D. We also report here that the catalytic efficiency of serotype A can be stimulated 35-fold by the addition of Triton X-100 to the reaction mixture. Combining the use of Triton X-100 with the newly introduced UPLC method, we were able to accurately detect very low levels of proteolytic activity in a very short time. Sensitivity of the assay and accuracy and rapidity of product analysis should greatly augment efforts in therapeutic development. Published by Elsevier Inc. C1 [Rowe, Benjamin; Schmidt, James J.; Ahmed, S. Ashraf] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Dept Biochem & Cell Biol, Ft Detrick, MD 21702 USA. [Smith, Leonard A.] USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Dept Mol Biol, Ft Detrick, MD 21702 USA. RP Ahmed, SA (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Dept Biochem & Cell Biol, Ft Detrick, MD 21702 USA. EM syed.ahmed@amedd.army.mil FU Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) [3.10011_06_RD_B, 3.10012_06_RD_B] FX The research described here was supported by the joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD, 3.10011_06_RD_B and 3.10012_06_RD_B). We thank Stephen I. Toth, Matthew L. Ludivico, and Trista Haupt for assistance with the UPLC setup and enzyme assays; Ernst Brueggemann for the mass spectrometry data: and John Cardellina for detergent structures. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. NR 31 TC 22 Z9 23 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD JAN 15 PY 2010 VL 396 IS 2 BP 188 EP 193 DI 10.1016/j.ab.2009.09.034 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 529GM UT WOS:000272504100004 PM 19782037 ER PT J AU Carmichael, MG Benavides, LC Holmes, JP Gates, JD Mittendorf, EA Ponniah, S Peoples, GE AF Carmichael, Mark G. Benavides, Linda C. Holmes, Jarrod P. Gates, Jeremy D. Mittendorf, Elizabeth A. Ponniah, Sathibalan Peoples, George E. TI Results of the First Phase 1 Clinical Trial of the HER-2/neu Peptide (GP2) Vaccine in Disease-Free Breast Cancer Patients SO CANCER LA English DT Article DE breast cancer; GP2; HER-2/neu; peptide; vaccine ID CYTOTOXIC T-LYMPHOCYTES; HER2/NEU E75 VACCINE; DENDRITIC CELLS; OVARIAN-CANCER; IN-VIVO; ANTIGEN; RECURRENCE; EXPRESSION; PREVENTION; INDUCTION AB BACKGROUND: HER-2/neu, overexpressed in breast cancer, is a source of immunogenic peptides that include GP2 and E75. Phase 2 testing of E75 as an adjuvant vaccine has suggested a clinical benefit. GP2, derived from the transmembrane portion of HER-2/neu, has differing binding characteristics and may be more immunogenic than E75. Results of the first phase 1 trial of GP2 peptide vaccine are presented. METHODS: Disease-free, lymph node-negative, human leukocyte antigen (HLA)-A2(+) breast cancer patients were enrolled. This dose escalation trial included 4 groups to determine safety and optimal GP2 peptide/granulocyte-macrophage colony-stimulating factor (GM-CSF) dose. Toxicities were monitored. Immunologic response was assessed ex vivo via the HLA-A2:immunoglobulin dimer assay to detect GP2-specific CD8(+) T cells (and E75-specific CD8+ T cells to assess epitope spreading) and in vivo via delayed type hypersensitivity (DTH) reaction (medians/ranges). RESULTS: Eighteen patients were enrolled. All toxicities were grade <= 2. Eight (88.9%) of 9 patients in the first 3 dose groups required GM-CSF dose reductions for local reactions >= 100 mm or grade >= 2 systemic toxicity. GM-CSF dose was reduced to 125 jig for the final dose group. All patients responded immunologically ex vivo (GP2-specific CD8(+) T cells from prevaccination to maximum, 0.4% [0.0%-2.0%] to 1.1% [0.4%-3.6%], P < .001) and in vivo (GP2 pre- to postvaccination DTH, 0 mm [0.0-19.5 mm] to 27.5 mm [0.0-114.5 mm, P < .001]. E75-specific CD8(+) T cells also increased in response to GP2 from prevaccination to maximum (0.8% [0.0%-2.41%] to 1.6% [0.86%-3.72%], P < .001). CONCLUSIONS: The GP2 peptide vaccine appears safe and well tolerated with minimal local/systemic toxicity. GP2 elicited HER-2/neu-specific immune responses, including epitope spreading, in high-risk, lymph node-negative breast cancer patients. These findings support further investigation of the GP2 vaccine for the prevention of breast cancer recurrence. Cancer 2010;116:292-301. (C) 2070 American Cancer Society. C1 [Benavides, Linda C.; Gates, Jeremy D.; Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Carmichael, Mark G.; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA. [Holmes, Jarrod P.] USN, San Diego Med Ctr, Dept Hematol & Med Oncol, San Diego, CA 92152 USA. [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM George.Peoples@amedd.army.mil FU United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Department of Clinical Investigation, Walter Reed Army Medical Center FX Supported by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, and the Department of Clinical Investigation, Walter Reed Army Medical Center. NR 22 TC 34 Z9 36 U1 0 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD JAN 15 PY 2010 VL 116 IS 2 BP 292 EP 301 DI 10.1002/cncr.24756 PG 10 WC Oncology SC Oncology GA 546QT UT WOS:000273826000008 PM 19924797 ER PT J AU Farley, JH Tian, CQ Rose, GS Brown, CL Birrer, M Risinger, JI Thigpen, JT Fleming, GF Gallion, HH Maxwell, GL AF Farley, John H. Tian, Chunqiao Rose, G. Scott Brown, Carol L. Birrer, Michael Risinger, John I. Thigpen, J. Tate Fleming, Gini F. Gallion, Holly H. Maxwell, G. Larry TI Chemotherapy Intensity and Toxicity Among Black and White Women With Advanced and Recurrent Endometrial Cancer A Gynecologic Oncology Group Study SO CANCER LA English DT Article DE endometrial cancer; chemotherapy; GOG ID DOXORUBICIN PLUS CISPLATIN; PHASE-III TRIAL; RACIAL DISPARITY; AFRICAN-AMERICAN; ADJUVANT CHEMOTHERAPY; BREAST-CANCER; STAGE; CARCINOMA; SURVIVAL; OVEREXPRESSION AB BACKGROUND: The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival. METHODS: A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetricians stage III, stage IV, or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose, relative time, and relative dose intensity. Treatment cycles >= 7 were defined as treatment completion. RESULTS. Although black patients were more likely to experience grades 3-4 anemia (20% vs 14%) and genitourinary (5% vs 1%) toxicity, and less likely to experience severe gastrointestinal toxicity (10% vs 17%), the overall incidence of grades 3-4 treatment-related chemotoxicity was the same between the 2 groups (82% vs 82%). There were no differences in the number of cycles received, relative dose (0.57 vs 0.58), relative time (0.77 vs 0.78), or relative dose intensity (0.76 vs 0.76) for black and white patients. CONCLUSIONS: Black patients with advanced stage or recurrent endometrial cancer, treated on 4 Gynecologic Oncology Group (GOG) protocols, had similar dose intensity and severe chemotherapy-related toxicity compared with white patients, suggesting that previously described racial disparities in survival among patients in GOG trials may have an novel etiology. Cancer 2010;116:355-61. (C) 2070 American Cancer Society. C1 [Farley, John H.; Rose, G. Scott] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20832 USA. [Tian, Chunqiao] Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA. [Brown, Carol L.] Mem Sloan Kettering Canc Ctr, Dept Surg, Gynecol Serv, Div Gynecol Oncol,Dept Obstet & Gynecol, New York, NY 10021 USA. [Birrer, Michael] NCI, Ctr Canc Res, Bethesda, MD 20892 USA. [Risinger, John I.] Mem Hlth Univ Med Ctr, Dept Lab Oncol Res, Curtis & Elizabeth Anderson Canc Inst, Savannah, GA 31404 USA. [Thigpen, J. Tate] Univ Mississippi, Div Oncol, Dept Med, Sch Med, Jackson, MS 39216 USA. [Fleming, Gini F.] Univ Chicago, Dept Med, Chicago, IL 60637 USA. [Gallion, Holly H.] Univ Pittsburgh, Magee Womens Res Inst, Dept Obstet & Gynecol & Reprod Serv, Pittsburgh, PA USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. [Maxwell, G. Larry] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Farley, JH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, 4301 Jones Bridge Rd, Bethesda, MD 20832 USA. EM john.farley@us.army.mil FU National Cancer Institute [CA 27,469]; Gynecologic Oncology Group Statistical Office [CA 37,517] FX This study was supported by National Cancer Institute grants to the Gynecologic Oncology Group Administrative Office (CA 27,469) and the Gynecologic Oncology Group Statistical Office (CA 37,517). NR 26 TC 7 Z9 7 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD JAN 15 PY 2010 VL 116 IS 2 BP 355 EP 361 DI 10.1002/cncr.24769 PG 7 WC Oncology SC Oncology GA 546QT UT WOS:000273826000016 PM 19924790 ER PT J AU Henz, BJ Hawa, T Zachariah, MR AF Henz, Brian J. Hawa, Takumi Zachariah, Michael R. TI On the role of built-in electric fields on the ignition of oxide coated nanoaluminum: Ion mobility versus Fickian diffusion SO JOURNAL OF APPLIED PHYSICS LA English DT Article DE alumina; aluminium; coatings; diffusion; ignition; ion mobility; molecular dynamics method; nanoparticles; oxidation ID OXIDATION; ALUMINUM; NANOPARTICLES; KINETICS; PARTICLES; GROWTH AB Using the classical molecular dynamics method we simulate the mechanochemical behavior of small (i.e., core diameter < 10 nm) oxide coated aluminum nanoparticles. Aluminum nanoparticles with core diameters of approximately 5 and 8 nm are simulated with 1 and 2 nm thick oxide coatings or shells. In addition to thickness the shells are parametrized by varying degrees of crystallinity, density, and atomic ratios in order to study their effect on the ignition of nanoparticle oxidation. The oxide shells are parametrized to consider oxide coatings with the defects that commonly occur during the formation of an oxide layer and for comparison with a defect free crystalline oxide shell. Computed results include the diffusion coefficients of aluminum cations for each shell configuration and over a range of temperatures. The observed results are discussed and compared with the ignition mechanisms reported in the literature. From this effort we have found that the oxidation ignition mechanism for nanometer sized oxide coated aluminum particles is the result of an enhanced transport due to a built-in electric field induced by the oxide shell. This is in contrast to the currently assumed pressure driven diffusion process. This induced electric field accounts for approximately 90% of the mass flux of aluminum ions through the oxide shell. The computed electric fields show good agreement with published theoretical and experimental results. C1 [Hawa, Takumi; Zachariah, Michael R.] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Hawa, Takumi; Zachariah, Michael R.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA. [Henz, Brian J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zachariah, MR (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM mrz@umd.edu FU U. S. Army Research Laboratory DoD Supercomputing Resource Center (DSRC); U. S. Army Research Office (ARO) FX The authors would like to acknowledge the support received by the U. S. Army Research Laboratory DoD Supercomputing Resource Center (DSRC) at the Aberdeen Proving Ground, MD. Additional support was provided by the U. S. Army Research Office (ARO). NR 24 TC 32 Z9 34 U1 2 U2 20 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 2010 VL 107 IS 2 AR 024901 DI 10.1063/1.3247579 PG 9 WC Physics, Applied SC Physics GA 551BM UT WOS:000274180600124 ER PT J AU Zubatyuk, RI Gorb, L Shishkin, OV Qasim, M Leszczynski, J AF Zubatyuk, Roman I. Gorb, Leonid Shishkin, Oleg V. Qasim, Mo Leszczynski, Jerzy TI Exploration of Density Functional Methods for One-Electron Reduction Potential of Nitrobenzenes SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article DE reduction potential; electron affinity; density functional methods; nitroaromatic compounds; solvation ID MOLECULAR-ORBITAL METHODS; GAUSSIAN-BASIS SETS; CORRELATION-ENERGY; THERMOCHEMICAL KINETICS; ORGANIC-MOLECULES; MODEL; AFFINITIES; GAS; ELECTROCHEMISTRY; APPROXIMATION AB Performance of the set of density functional approaches for calculation of one-electron reduction potentials of nitroaromatic compounds was investigated. To select the most precise and affordable method, we selected a set of model molecules and investigated effects of basis set, density functional, and solvation model on the calculation of reduction potentials. It was found that the mPWB1K/TZVP method provides the most accurate gas phase electron affinity values (RMS error is 0.1 eV). This method in conjunction with the PCM (Bondi) method yields also the most accurate difference in solvation energies of neutral oxidized form and anion-radical reduced form. The final Eo values were calculated with RMS error of 0.10 V, compared with experimental values. (c) 2009 Wiley Periodicals, Inc. J Comput Chem 31: 144-150, 2010 C1 [Qasim, Mo; Leszczynski, Jerzy] USA, ERDC, Vicksburg, MS 39180 USA. [Gorb, Leonid] SpecPro Inc, NW Huntsville, AL 35805 USA. [Zubatyuk, Roman I.; Shishkin, Oleg V.] Natl Acad Sci Ukraine, STC Inst Single Crystals, UA-61001 Kharkov, Ukraine. [Leszczynski, Jerzy] Jackson State Univ, Interdisciplinary Nanotox Ctr, Jackson, MS 39217 USA. RP Leszczynski, J (reprint author), USA, ERDC, Vicksburg, MS 39180 USA. EM jerzy@ccmsi.us OI Zubatyuk, Roman/0000-0002-7285-9389 FU NSF [EPSCoR 440900362427-02] FX NSF: contract/grant number: EPSCoR 440900362427-02 NR 49 TC 16 Z9 16 U1 0 U2 13 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD JAN 15 PY 2010 VL 31 IS 1 BP 144 EP 150 DI 10.1002/jcc.21301 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA 538LU UT WOS:000273186800012 PM 19422001 ER PT J AU Walsh, MR Walsh, ME Hewitt, AD AF Walsh, Michael R. Walsh, Marianne E. Hewitt, Alan D. TI Energetic residues from field disposal of gun propellants SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article DE Propellants; Residues; Expedient field disposal; Military; Energetics ID EXPLOSIVES-RESIDUES; SALT-MARSH; LIVE-FIRE; RANGES; DETONATIONS AB Military training with howitzers and mortars produces excess propellant that is burned on the training range and can result in point sources containing high concentrations of unreacted propellant constituents. Propellants contain energetic compounds such as nitroglycerin (NG) and 2,4-dinitrotoluene (2,4-DNT), both of which are found at firing positions and propellant disposal areas. To quantify the mass of residue remaining from the field-expedient disposal of propellants, two mortar propellants and one howitzer propellant were burned under different field conditions. These conditions included burning on a snow pack, at the bottom of a snow pit, and in a pan surrounded by snow for the mortar propellants and on dry and wet sand for the howitzer propellant. For the mortar propellant, the energetics (NG) remaining after burning in the bowl, on frozen ground, and on snow were 0.21%,5.2% and 18%. respectively. For the howitzer propellant, the difference in energetics (2,4-DNT) remaining after disposal on wet and dry sand was <0.1%, with the overall residue rate of around 1%, similar to that for the mortar propellant burned in an open container. These tests demonstrate that environmental factors, especially in winter, can play a significant role in the effectiveness of field-expedient disposal of propellants. Published by Elsevier B.V. C1 [Walsh, Michael R.; Walsh, Marianne E.; Hewitt, Alan D.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Walsh, MR (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Michael.Walsh@usace.army.mil FU US Department of Defense; SERDP [ER-1481] FX This research was funded by the US Department of Defense through the Strategic Environmental Research and Environmental Program, Dr. Andrea Leeson, Environmental Program Manager. The project title is Characterization and Fate of Gun and Rocket Propellant Residues on Testing and Training Ranges, SERDP Project ER-1481, Michael R. Walsh, principal investigator. The sponsor took no active role in any of the activities associated with this paper other than approving the scope of work for the project and providing funding. The authors wish to express our appreciation to Dr. Leeson and SERDP for providing the opportunity to conduct this research in this emerging field. The authors are employees of the US Army Corps of Engineers. NR 16 TC 8 Z9 9 U1 1 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD JAN 15 PY 2010 VL 173 IS 1-3 BP 115 EP 122 DI 10.1016/j.jhazmat.2009.08.056 PG 8 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 537SZ UT WOS:000273135600015 PM 19758750 ER PT J AU Ganesan, A Chattopadhyay, PK Brodie, TM Qin, J Gu, WJ Mascola, JR Michael, NL Follmann, DA Roederer, M AF Ganesan, Anuradha Chattopadhyay, Pratip K. Brodie, Tess M. Qin, Jing Gu, Wenjuan Mascola, John R. Michael, Nelson L. Follmann, Dean A. Roederer, Mario CA Infect Dis Clinical Res Program HI TI Immunologic and Virologic Events in Early HIV Infection Predict Subsequent Rate of Progression SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CD8(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; MULTICENTER AIDS COHORT; VIRUS TYPE-1 INFECTION; ACUTE SIV INFECTION; IMMUNE ACTIVATION; INTERLEUKIN-7 RECEPTOR; DISEASE PROGRESSION; HIV-1-INFECTED PATIENTS; COLLABORATIVE ANALYSIS AB Background. Variability in human immunodeficiency virus (HIV) disease progression cannot be fully predicted by CD4(+) T cell counts or viral load (VL). Because central memory T (T(CM)) cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, we hypothesized that quantifying these cells in early HIV infection could provide prognostic information. Methods. We measured expression of CD45RO, chemokine (C-C motif) receptor (CCR) 5, CCR7, CD27, and CD28 to enumerate naive and memory subsets in samples from recently infected individuals. We also quantified proliferation, CD127 expression, and cell-associated VL. Disease progression was compared across subgroups defined by these measurements, using Kaplan-Meier survival curves and multivariate Cox proportional hazards regression. Results. Four hundred sixty-six subjects contributed 101 events. The proportion or absolute count of T(CM) cells did not correlate with disease progression, defined as the time to AIDS or death. However, significant associations were observed for proliferation within CD4(+) or CD8(+) T cells, loss of naive or CD127(+) memory CD8(+) T cells, and CD4(+) T cell-associated VL. Conclusions. Our results demonstrate that the extent of the immunopathogenesis established early in HIV infection predicts the course of future disease. Because antiretroviral drug treatment reverses such defects in part, our study provides mechanistic clues to why early use of antiretrovirals may prove beneficial. C1 [Ganesan, Anuradha] Uniformed Serv Univ Hlth Sci, Natl Naval Med Ctr, Infect Dis Clin Res Program, Bethesda, MD USA. [Chattopadhyay, Pratip K.; Brodie, Tess M.; Mascola, John R.; Roederer, Mario] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Follmann, Dean A.] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. [Gu, Wenjuan] Sci Applicat Int Corp, Biostat Res Branch, Frederick, MD USA. [Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD USA. RP Roederer, M (reprint author), NIH, ImmunoTechnol Sect, Vaccine Res Ctr, 40 Convent Dr,Rm 5509, Bethesda, MD 20892 USA. EM Roederer@nih.gov RI Chattopadhyay, Pratip/B-9227-2008; Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669; Chattopadhyay, Pratip/0000-0002-5457-9666 FU CCR NIH HHS [HHSN261200800001C]; Intramural NIH HHS [Z99 AI999999, ZIA AI005021-08]; NCI NIH HHS [HHSN261200800001E] NR 49 TC 44 Z9 47 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN 15 PY 2010 VL 201 IS 2 BP 272 EP 284 DI 10.1086/649430 PG 13 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 536NN UT WOS:000273051200014 PM 20001854 ER PT J AU Milhous, WK Weina, PJ AF Milhous, Wilbur K. Weina, Peter J. TI The Botanical Solution for Malaria SO SCIENCE LA English DT Editorial Material ID ANTIMALARIAL-DRUG; ARTEMISININ; ARTEETHER C1 [Milhous, Wilbur K.] Univ S Florida, Coll Publ Hlth, Tampa, FL 33612 USA. [Weina, Peter J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Milhous, WK (reprint author), Univ S Florida, Coll Publ Hlth, Tampa, FL 33612 USA. EM wmilhous@health.usf.edu NR 8 TC 9 Z9 9 U1 0 U2 10 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA SN 0036-8075 J9 SCIENCE JI Science PD JAN 15 PY 2010 VL 327 IS 5963 BP 279 EP 280 DI 10.1126/science.1184780 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 544CM UT WOS:000273629700025 PM 20075238 ER PT J AU Lehman, RA Dmitriev, AE Cardoso, MJ Helgeson, MD Christensen, CL Raymond, JW Eckel, TT Riew, KD AF Lehman, Ronald A., Jr. Dmitriev, Anton E. Cardoso, Mario J. Helgeson, Melvin D. Christensen, Christine L. Raymond, JoLynne W. Eckel, Tobin T. Riew, K. Daniel TI Effect of Teriparatide [rhPTH(1,34)] and Calcitonin on Intertransverse Process Fusion in a Rabbit Model SO SPINE LA English DT Article DE parathyroid hormone; calcitonin; osteoporosis; rabbit model; teriparatide ID PARATHYROID-HORMONE 1-34; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; OVARIECTOMIZED RATS; ALENDRONATE; THERAPY; RALOXIFENE; FRACTURES; INCREASES AB Study Design. Randomized, double-blinded, placebo controlled animal study. Objective. To evaluate the effect of teriparatide and calcitonin after an intertransverse process spinal fusion in a rabbit model. Summary of Background Data. It is widely recognized that some osteoporosis medications, including bisphosphonates, can interfere with bone healing. Although prescribed frequently in the treatment of osteoporosis, the effect of teriparatide and calcitonin on spinal fusion has not been fully elucidated. We hypothesized that teriparatide, being the only anabolic medication for osteoporosis treatment, would have a beneficial effect on spine fusion. Methods. Fifty-one New Zealand white rabbits underwent a posterolateral L5-L6 intertransverse process arthrodesis using autogenous iliac crest bone graft. The rabbits were randomly divided into 3 groups. All animals received daily subcutaneous injections of group I (n = 17) 1 mL of saline placebo; group II (n = 17) 10 mu g/kg/day of teriparatide; group III (n = 17) 14 IU/animal of calcitonin during the 8-week postoperative period. Postmortem analyses included manual palpation, radiographic, bio-mechanical, and histologic assessment. Three random 10x fields were examined/graded within the cephalad, middle, and caudal regions of each section (810 fields). Fusion quality was graded using the Emery histologic scale (0-7 based on fibrous/bone content of the fusion mass). Results. Histologic fusion rates for teriparatide averaged 86.7% and was significantly greater than the autograft control group (50%) (P = 0.033). Radiographically, there was a strong trend towards teriparatide being superior to the calcitonin group (85.7% vs. 56.3%, respectively; P = 0.07). The average Emery grading score was 5.99 +/- 1.46 SD for the autologous group and 6.26 +/- 0.93 SD for the teriparatide group (P = 0.031). Although not significant, the teriparatide group showed less motion in flexion/extension, lateral bending, and axial rotation. Conclusion. Our results suggest that teriparatide enhances spinal fusion while calcitonin has a neutral effect. The teriparatide group had the best histologic fusion rate and Emery scores, while the calcitonin group was similar to the saline controls. Although not significant, the teriparatide group had a strong trend towards superior radiographic fusion over the calcitonin group. C1 [Lehman, Ronald A., Jr.; Dmitriev, Anton E.; Cardoso, Mario J.; Helgeson, Melvin D.; Eckel, Tobin T.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Christensen, Christine L.; Raymond, JoLynne W.] Armed Forces Inst Pathol, Dept Vet Pathol, Washington, DC 20306 USA. [Riew, K. Daniel] WA Univ, Dept Orthopaed Surg, Sch Med, St Louis, MO USA. RP Lehman, RA (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed Surg, 1528 Blue Meadow Rd, Potomac, MD 20854 USA. EM ronald.lehman@amedd.army.mil NR 41 TC 18 Z9 19 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JAN 15 PY 2010 VL 35 IS 2 BP 146 EP 152 DI 10.1097/BRS.0b013e3181b71a96 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 551WY UT WOS:000274245300004 PM 20081509 ER PT J AU Helgeson, MD Shah, SA Newton, PO Clements, DH Betz, RR Marks, MC Bastrom, T AF Helgeson, Melvin D. Shah, Suken A. Newton, Peter O. Clements, David H., III Betz, Randal R. Marks, Michelle C. Bastrom, Tracey CA Harms Study Grp TI Evaluation of Proximal Junctional Kyphosis in Adolescent Idiopathic Scoliosis Following Pedicle Screw, Hook, or Hybrid Instrumentation SO SPINE LA English DT Article DE idiopathic scoliosis; deformity; sagittal balance; proximal kyphosis; instrumentation; surgical treatment ID POSTERIOR SPINAL-FUSION AB Study Design. Retrospective review. Objective. To compare the incidence of and risk factors for proximal junctional kyphosis (PJK) in adolescent idiopathic scoliosis (AIS) following posterior spinal fusion using hook, pedicle screw, or hybrid constructs. Summary of Background Data. Proximal junctional kyphosis is a recently recognized phenomenon in adults and adolescents after AIS surgery. The postoperative effect on PJK with the use of hooks, hybrid constructs, or screws has not been compared in a multicenter study to date. Methods. From a multicenter database, the preoperative and 2-year follow-up radiographic measurements from 283 patients with AIS treated with posterior spinal fusion using hooks (group 1, n = 51), hybrid constructs (group 2, n = 177), pedicle screws (group 3, n = 37), and pedicle screws with hooks only at the top level (group 4, n = 18) were compared. Results. The average proximal level kyphosis at 2 years after surgery was 8.2 degrees (range -1 to 18) in the all screw constructs, representing a significant increase when compared with hybrid and all hook constructs, 5.7 degrees (P = 0.02) and 5.0 degrees (P = 0.014), respectively. Conversely, average postoperative T5-T12 kyphosis was significantly less (P = 0.016) in the screw group compared with the all hook group. Of potential interest, but currently not statistically significant, was the trend towards a decrease in proximal kyphosis in constructs with all pedicle screws except hooks at the most cephalad segment, 6.4. The incidence of PJK (assuming PJK is a kyphotic deformity greater than 15) was 0% in group 1, 2.3% in group 2, 8.1% in group 3, and 5.6% in group 4 (P = 0.18). Patients with PJK had an increased body mass index compared with those who did not meet criteria for PJK (P = 0.013). Conclusion. Adjacent level proximal kyphosis was significantly increased with pedicle screws, but the clinical significance of this is unclear. A potential solution is the substitution of hooks at the upper-instrumented vertebrae, but further investigation is required. C1 [Shah, Suken A.] Alfred I Dupont Hosp Children, Nemours Childrens Clin, Wilmington, DE 19899 USA. [Helgeson, Melvin D.] Walter Reed Army Med Ctr, Wa, DC USA. [Newton, Peter O.; Marks, Michelle C.; Bastrom, Tracey] Rady Childrens Hosp, San Diego, CA USA. [Clements, David H., III] Univ Hosp, Cooper Bone & Joint Inst, Camden, NJ USA. [Betz, Randal R.] Shriners Hosp Children, Philadelphia, PA USA. RP Shah, SA (reprint author), Alfred I Dupont Hosp Children, Nemours Childrens Clin, 1600 Rockland Rd,POB 269, Wilmington, DE 19899 USA. EM sshah@nemours.org FU Corporate/Industrial funds FX Corporate/Industrial funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript. NR 11 TC 56 Z9 62 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JAN 15 PY 2010 VL 35 IS 2 BP 177 EP 181 DI 10.1097/BRS.0b013e3181c77f8c PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 551WY UT WOS:000274245300008 PM 20081513 ER PT J AU Bednar, AJ Jones, WT Chappell, MA Johnson, DR Ringelberg, DB AF Bednar, A. J. Jones, W. T. Chappell, M. A. Johnson, D. R. Ringelberg, D. B. TI A modified acid digestion procedure for extraction of tungsten from soil SO TALANTA LA English DT Article DE Tungsten; Acid digestion; Extraction procedures ID ADSORPTION; MOLYBDATE; NEVADA AB Interest in tungsten Occurrence and geochemistry is increasing due to increased use of tungsten compounds and its unknown biochemical effects. Tungsten has a complex geochemistry, existing in most environmental matrices as the soluble and mobile tungstate anion, as well as poly- and heteropoly-tungstates. Because the geochemistry of tungsten is substantially different than most trace metals, including the formation of insoluble species under acidic conditions, it is not extracted from soil matrices using standard acid digestion procedures. Therefore, the current work describes a modification to a commonly used acid digestion procedure to facilitate quantification of tungsten in soil matrices. Traditional soil digestion procedures, using nitric and hydrochloric acids with hydrogen peroxide yield < 1 up to 50% recovery on soil matrix spike samples, whereas the modified method reported here, which includes the addition of phosphoric acid, yields spike recoveries in the 76-98% range. Comparison of the standard and modified digestion procedures on National Institute of Standards and Technology Standard Reference Materials yielded significantly improved tungsten recoveries for the phosphoric acid modified method. The modified method also produces comparable results for other acid extractable metals as the standard methods, and therefore can be used simultaneously for tungsten and other metals of interest. Published by Elsevier B.V. C1 [Bednar, A. J.; Jones, W. T.; Chappell, M. A.; Johnson, D. R.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Ringelberg, D. B.] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Bednar, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@usace.army.mil NR 22 TC 4 Z9 4 U1 5 U2 18 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD JAN 15 PY 2010 VL 80 IS 3 BP 1257 EP 1263 DI 10.1016/j.talanta.2009.09.017 PG 7 WC Chemistry, Analytical SC Chemistry GA 547ZZ UT WOS:000273929900033 PM 20006084 ER PT J AU Landrum, ML Fieberg, AM Chun, HM Crum-Cianflone, NF Marconi, VC Weintrob, AC Ganesan, A Barthel, RV Wortmann, G Agan, BK AF Landrum, Michael L. Fieberg, Ann M. Chun, Helen M. Crum-Cianflone, Nancy F. Marconi, Vincent C. Weintrob, Amy C. Ganesan, Anuradha Barthel, Robert V. Wortmann, Glenn Agan, Brian K. TI The Effect of Human Immunodeficiency Virus on Hepatitis B Virus Serologic Status in Co-Infected Adults SO PLOS ONE LA English DT Article ID ACTIVE ANTIRETROVIRAL THERAPY; T-CELL RESPONSES; NATURAL-HISTORY; HBV INFECTION; HIV-INFECTION; SEROCONVERSION; RECOMMENDATIONS; COINFECTION; MANAGEMENT; MORTALITY AB Background: Factors associated with serologic hepatitis B virus (HBV) outcomes in HIV-infected individuals remain incompletely understood, yet such knowledge may lead to improvements in the prevention and treatment of chronic HBV infection. Methods and Findings: HBV-HIV co-infected cohort participants were retrospectively analyzed. HBV serologic outcomes were classified as chronic, resolved, and isolated-HBcAb. Chronic HBV (CHBV) was defined as the presence of HBsAg on two or more occasions at least six months apart. Risk factors for HBV serologic outcome were assessed using logistic regression. Of 2037 participants with HBV infection, 281 (14%) had CHBV. Overall the proportions of HBV infections classified as CHBV were 11%, 16%, and 19% for CD4 cell count strata of >= 500, 200-499, and,200, respectively (p<0.0001). Risk of CHBV was increased for those with HBV infection occurring after HIV diagnosis (OR 2.62; 95% CI 1.78-3.85). This included the subset with CD4 count >= 500 cells/mu L where 21% of those with HBV after HIV diagnosis had CHBV compared with 9% for all other cases of HBV infection in this stratum (p = 0.0004). Prior receipt of HAART was associated with improved HBV serologic outcome overall (p = 0.012), and specifically among those with HBV after HIV (p = 0.002). In those with HBV after HIV, HAART was associated with reduced risk of CHBV overall (OR 0.18; 95% CI 0.04-0.79); including reduced risk in the subsets with CD4 >= 350 cells/mu L (p<0.001) and CD4 >= 500 cells/mu L (p = 0.01) where no cases of CHBV were seen in those with a recent history of HAART use. Conclusions: Clinical indicators of immunologic status in HIV-infected individuals, such as CD4 cell count, are associated with HBV serologic outcome. These data suggest that immunologic preservation through the increased use of HAART to improve functional anti-HBV immunity, whether by improved access to care or earlier initiation of therapy, would likely improve HBV infection outcomes in HIV-infected individuals. C1 [Landrum, Michael L.; Fieberg, Ann M.; Weintrob, Amy C.; Ganesan, Anuradha; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Landrum, Michael L.; Crum-Cianflone, Nancy F.; Marconi, Vincent C.] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Fieberg, Ann M.] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Chun, Helen M.] USN, Hlth Res Ctr, Dept Def HIV AIDS Prevent Program, San Diego, CA USA. [Crum-Cianflone, Nancy F.] USN, Med Ctr, Infect Dis Clin, San Diego, CA USA. [Weintrob, Amy C.; Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Div Infect Dis, Bethesda, MD USA. [Barthel, Robert V.] USN, Med Ctr, Div Infect Dis, Portsmouth, VA USA. RP Landrum, ML (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM mlandrum@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU IDCRP [G187YS-RV198]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP# G187YS-RV198) was provided by the Infectious Disease Clinical Research Program (IDCRP, www. idcrp. org), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. The IDCRP reviewed the study design, collected the data, and provided salary support to investigators (M. L. L. A. M. F., N. F. C., A. C. W., A. G., and B. K. A.). The analyses, conclusions and decision to submit the manuscript are the independent work and decision of the authors. The NIH had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 33 TC 13 Z9 13 U1 0 U2 0 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD JAN 13 PY 2010 VL 5 IS 1 AR e8687 DI 10.1371/journal.pone.0008687 PG 7 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 543EV UT WOS:000273554600036 PM 20084275 ER PT J AU Duddu, R Dave, PR Damavarapu, R Gelber, N Parrish, D AF Duddu, Raja Dave, Paritosh R. Damavarapu, Reddy Gelber, Nathaniel Parrish, Damon TI Synthesis of N-amino- and N-nitramino-nitroimidazoles SO TETRAHEDRON LETTERS LA English DT Article ID 1-METHYL-2,4,5-TRINITROIMIDAZOLE MTNI; ENERGETIC MATERIALS; MESITYLENESULFONYLHYDROXYLAMINE AB Synthesis of anew nitro-substituted 1-amino and 1-nitraminoimidazoles is described. A novel solid state nitration has been developed. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Duddu, Raja; Dave, Paritosh R.] USA, SAIC, ARDEC, Picatinny Arsenal, NJ 07806 USA. [Parrish, Damon] USN, Res Lab, Struct Matter Lab, Washington, DC 20375 USA. RP Duddu, R (reprint author), USA, SAIC, ARDEC, Bldg 3028, Picatinny Arsenal, NJ 07806 USA. EM raja.duddu@us.army.mil NR 20 TC 28 Z9 34 U1 2 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0040-4039 J9 TETRAHEDRON LETT JI Tetrahedron Lett. PD JAN 13 PY 2010 VL 51 IS 2 BP 399 EP 401 DI 10.1016/j.tetlet.2009.11.046 PG 3 WC Chemistry, Organic SC Chemistry GA 553OI UT WOS:000274376300047 ER PT J AU Hassantoufighi, A Zhang, H Sandbulte, M Gao, J Manischewitz, J King, L Golding, H Straight, TM Eichelberger, MC AF Hassantoufighi, Arash Zhang, Henry Sandbulte, Matthew Gao, Jin Manischewitz, Jody King, Lisa Golding, Hana Straight, Timothy M. Eichelberger, Maryna C. TI A practical influenza neutralization assay to simultaneously quantify hemagglutinin and neuraminidase-inhibiting antibody responses SO VACCINE LA English DT Article DE Influenza; Neutralization assay; Neuraminidase ID A H5N1 VIRUS; AVIAN INFLUENZA; POULTRY WORKERS; HONG-KONG; VACCINE; INFECTION; CHILDREN; LIVE; IMMUNOGENICITY; INTRANASAL AB Influenza vaccine immunogenicity is commonly assessed by determining hemagglutination inhibition (HAI) titers in serum samples. HAI titers have been used to predict vaccine efficacy, but this often fails when live attenuated vaccines are evaluated, because it does not encompass all immune mediators of protection. Although antibodies that inhibit viral neuraminidase (NA) also contribute to protection against disease, there is currently no routine assessment of NA inhibition titers. A serological method with the capacity to measure functional inhibition of both HA and NA would be valuable We developed a high-throughput virus neutralization assay that uses viral NA activity to quantify influenza replication (the AVINA assay), and showed its capacity to identify antivirals with a broad range of target specificities In this report we demonstrate that antibodies with specificity for either HA or NA are detected in this assay, whereas a commonly used virus neutralization assay only detects those with HA-specificity. We also compared human responses to seasonal influenza vaccines measured by HAI, micro-neutralization, NA inhibition and AVINA assays. The response rates to both trivalent inactivated and live attenuated vaccines were greater when measured by the AVINA than the other assays, reflecting the dual antigen reactivity and increased sensitivity of the assay The potential of this single assay to predict protection against influenza-induced tachypnea was demonstrated in vaccinated cotton rats. The AVINA assay is therefore a practical, comprehensive method to determine influenza vaccine immunogenicity and potential efficacy. Published by Elsevier Ltd. C1 [Hassantoufighi, Arash; Zhang, Henry; Sandbulte, Matthew; Gao, Jin; Manischewitz, Jody; King, Lisa; Golding, Hana; Eichelberger, Maryna C.] US FDA, Div Viral Prod, CBER, Off Vaccine Res & Review, Bethesda, MD 20892 USA. [Straight, Timothy M.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Eichelberger, MC (reprint author), US FDA, Div Viral Prod, CBER, Off Vaccine Res & Review, 8800 Rockville Pike,Bldg 29A,Room 1D24, Bethesda, MD 20892 USA. NR 27 TC 34 Z9 34 U1 1 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JAN 8 PY 2010 VL 28 IS 3 BP 790 EP 797 DI 10.1016/j.vaccine.2009.10.066 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 561YE UT WOS:000275015200026 PM 19887135 ER PT B AU Rogers, CM Hofseth, KD Males, RM AF Rogers, Cory M. Hofseth, Keith D. Males, Richard M. BE Bruzzone, A Cunha, G Frydman, C Giambiasi, N Mekouar, K Merkuriev, Y Piera, MA TI DATA ANALYSIS AND PROCESSING TOOL FOR AUTOMATIC IDENTIFICATION SYSTEM (AIS) VESSEL DATA TO SUPPORT SIMULATION MODELING SO 13TH INTERNATIONAL CONFERENCE ON HARBOR MARITIME MULTIMODAL LOGISTICS MODELING & SIMULATION LA English DT Proceedings Paper CT 13th International Conference on Harbor Maritime Multimodal Logistics Modeling and Simulation CY OCT 13-15, 2010 CL Fez, MOROCCO SP DIPTEM Univ Genoa, Liophant Simulat, Ecole Superieure Ingn Sci Appliquees, Univ Aix Marseille, Lab Sci Informat Syst, Univ Calabria, Mech Dept, Model & Simulat Ctr, Lab Enterprise Solut, MSLS Autonomous Univ Barcelona, Simulat Team, McLeod Inst Simulat Sci, Model & Simulat Network, Int Mediterranean & Latin Amer Council Simulat, Univ La Laguna, Riga Tech Univ, Miss Latvian Ctr, Univ Autonomous Barcelona, Miss Spanish Ctr, Univ Perugia, Management & Adv Solut & Technol, LAMCE, UFRJ, CIFASIS CONICET UNR UPCAM DE port simulation; automated identification system AB Automated Identification System (AIS) data provides ship tracking information for cargo vessels in coastal waters. Information includes vessel position, speed, draught, dimensions, and destination port. This information is updated on an hourly basis. The analysis of MS data for individual vessels and for a given port provides a large amount of useful information on vessel routes and loading that can be used in conjunction with port simulation models. The Institute for Water Resources of the US. Army Corps of Engineers is developing the Automatic Identification System - Data Analysis and. Pre-Processor (AIS-DAPP) tool for visualization and analysis that can be used to support simulation modeling and planning activities. The AIS-DAPP applies genome sequencing practices to identify services from the data. It also works seamlessly with Google Earth (TM) for spatial visualization and incorporates analytical routines to determine common routes, speed within channels, and draught entering and leaving a port, all needed for simulation modeling. C1 [Rogers, Cory M.] CDM, Carbondale, IL USA. [Hofseth, Keith D.] US Army Corps Engn, Inst Water Resources, Alexandria, VA USA. [Males, Richard M.] RMM Tech Serv Inc, Little Falls, NJ USA. RP Rogers, CM (reprint author), CDM, Carbondale, IL USA. EM rogerscm@cdm.com; keith.d.hofseth@usace.army.mil; males@iac.net FU Institute for Water Resources of the U.S. Army Corps of Engineers FX This work was carried out as part of the navigation research being performed at the Institute for Water Resources of the U.S. Army Corps of Engineers, under the direction of Mr. Keith Hofseth. The research conducted to define appropriate regions, map ports to regions and identify current vessel services was carried out by Ms. Shana Heisey of Watertown, Massachusetts. Computer programming services and algorithm enhancements were performed by Mr. Michael Dean and Mr. William Woelbeling of CDM, Carbondale, Illinois. NR 7 TC 0 Z9 0 U1 0 U2 5 PU DIPTEM UNIV GENOA PI GENOA PA VIA OPERA OUA 15, GENOA, 16145, ITALY BN 978-2-9524747-4-0 PY 2010 BP 47 EP + PG 3 WC Engineering, Manufacturing; Operations Research & Management Science; Transportation Science & Technology SC Engineering; Operations Research & Management Science; Transportation GA BED20 UT WOS:000316153400007 ER PT S AU Sardellitti, S Barbarossa, S Swami, A AF Sardellitti, S. Barbarossa, S. Swami, A. BE Kleijn, B Larsen, J TI AVERAGE CONSENSUS WITH MINIMUM ENERGY CONSUMPTION: OPTIMAL TOPOLOGY AND POWER ALLOCATION SO 18TH EUROPEAN SIGNAL PROCESSING CONFERENCE (EUSIPCO-2010) SE European Signal Processing Conference LA English DT Proceedings Paper CT 18th European Signal Processing Conference (EUSIPCO) CY AUG 23-27, 2010 CL Aalborg, DENMARK SP Aalborg Univ, European Assoc Signal, Speech, & Image Proc ID NETWORKS; SYSTEMS AB Consensus algorithms have generated a lot of interest due to their simplicity in computing globally relevant statistics exploiting only local communications among sensors. However, the inherent iterative nature of consensus algorithms makes them prone to a possibly large energy consumption. Because of the strong energy constraints of wireless sensor networks, it is then of interest to minimize energy consumption necessary to achieve consensus, within a prescribed accuracy requirement. In this work, we propose a method for optimizing the network topology and power allocation over each link, in order to minimize energy consumption, while ensuring that the network reaches a global consensus. Interestingly, we show how to introduce a relaxation in the topology optimization that converts a combinatorial problem into a convex-concave fractional problem. The results show how the sparsity of the resulting network depends on the propagation model. C1 [Sardellitti, S.; Barbarossa, S.] Univ Roma La Sapienza, INFOCOM Dept, I-00184 Rome, Italy. [Swami, A.] Army Res Lab, Adelphi, MD 20783 USA. RP Sardellitti, S (reprint author), Univ Roma La Sapienza, INFOCOM Dept, Via Eudossiana 18, I-00184 Rome, Italy. EM Stefania.Sardellitti@uniroma1.it; sergio@infocom.uniroma1.it; a.swami@ieee.org OI Barbarossa, Sergio/0000-0001-9846-8741; Sardellitti, Stefania/0000-0002-4749-2933 NR 18 TC 0 Z9 0 U1 0 U2 1 PU EUROPEAN ASSOC SIGNAL SPEECH & IMAGE PROCESSING-EURASIP PI KESSARIANI PA PO BOX 74251, KESSARIANI, 151 10, GREECE SN 2076-1465 J9 EUR SIGNAL PR CONF PY 2010 VL 18 BP 189 EP 193 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BC1DO UT WOS:000349999100039 ER PT S AU Ramirez, AB Arce, GR Sadler, BM AF Ramirez, Ana B. Arce, Gonzalo R. Sadler, Brian M. BE Kleijn, B Larsen, J TI FAST ALGORITHMS FOR RECONSTRUCTION OF SPARSE SIGNALS FROM CAUCHY RANDOM PROJECTIONS SO 18TH EUROPEAN SIGNAL PROCESSING CONFERENCE (EUSIPCO-2010) SE European Signal Processing Conference LA English DT Proceedings Paper CT 18th European Signal Processing Conference (EUSIPCO) CY AUG 23-27, 2010 CL Aalborg, DENMARK SP Aalborg Univ, European Assoc Signal, Speech, & Image Proc AB Recent work on dimensionality reduction using Cauchy random projections has emerged for applications where l(1) distance preservation is preferred. An original sparse signal b is an element of R-n is multiplied by a Cauchy random matrix R is an element of R-nxk (k << n), resulting in a projected vector c is an element of R-k. Two approaches for fast recover of b from the Cauchy vector c are proposed. The two algorithms are based on a regularized coordinate-descent Myriad regression using both l(0) and convex relaxation as sparsity inducing terms. The key element is to start, in the first iteration, by finding the optimal estimate value for each coordinate, and selectively updating only the coordinates with rapid descent in subsequent iterations. For the particular case of the l(0) regularized approach, an approximation function for the l(0)-norm is given due to it is non-differentiable norm [1]. Performance comparisons of the proposed approaches to the original regularized coordinate-descent method are included. C1 [Ramirez, Ana B.; Arce, Gonzalo R.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Sadler, Brian M.] US Army, Res Lab, Adelphi, MD USA. [Ramirez, Ana B.] Ind Univ Santander, Dept Elect Engn, Bucaramanga, Colombia. RP Ramirez, AB (reprint author), Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. FU National Science Foundation [ECCS-0725422, CCF-0915800] FX This work was supported in part by the National Science Foundation under the Grants ECCS-0725422 and CCF-0915800. NR 12 TC 0 Z9 0 U1 0 U2 1 PU EUROPEAN ASSOC SIGNAL SPEECH & IMAGE PROCESSING-EURASIP PI KESSARIANI PA PO BOX 74251, KESSARIANI, 151 10, GREECE SN 2076-1465 J9 EUR SIGNAL PR CONF PY 2010 VL 18 BP 432 EP 436 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BC1DO UT WOS:000349999100088 ER PT S AU Crutcher, SH Osei, AJ AF Crutcher, Sihon H. Osei, Albert J. BE Oluseyi, HM TI Spatial Beam Propagation with a Perturbation in a Nonlinear Medium with Power Law SO 2009 JOINT ANNUAL CONFERENCE OF THE NATIONAL SOCIETY OF BLACK PHYSICISTS AND THE NATIONAL SOCIETY OF HISPANIC PHYSICISTS, PROCEEDINGS SE AIP Conference Proceedings LA English DT Proceedings Paper CT 6th Joint Annual Meeting of the National-Society-of-Black-Physicists/National-Society-of-Hispanic-Physic s CY FEB 11-15, 2009 CL Fisk Univ, Nashville, TN SP Natl Sci Fdn, Natl Aeronautics & Space Adm, Us Dept Energy, Off Naval Res (ONR), Fisk Univ, Vanderbilt Univ HO Fisk Univ DE optical spatial soliton; equivalence particle theory; Nonlinear Schrodinger Equation; swing effect; Non-Kerr; Generalized Nonlinear Schrodinger Equation; power law ID OPTICAL SOLITONS; WAVE-GUIDE; KERR AB Oscillatory behavior of spatial solitons in a waveguide constituted by a medium with a transverse triangular index profile is investigated. Dynamics of such solitons are analyzed using the equivalent particle principle. Using this principle, expressions for acceleration, spatial frequency, spatial period and other variables for a spatial soliton can be derived from the solution of the basic Nonlinear Schrodinger Equation. Results obtained are in good agreement with numerical simulations of the Modified Nonlinear Schrodinger Equation. Expression of the acceleration is bounded in some cases resulting in an oscillatory behavior or a "swing effect" of the spatial soliton. We further apply the equivalent particle approach to the perturbed Nonlinear Schrodinger Equation with power law to show that the transverse acceleration also has a swing effect. C1 [Crutcher, Sihon H.] USA, Res Dev & Engn Command, Bldg 5400, Redstone Arsenal, AL 35898 USA. [Osei, Albert J.] Oakwood Univ, Dept Math & Comp Sci, Huntsville, AL 35896 USA. RP Crutcher, SH (reprint author), USA, Res Dev & Engn Command, Bldg 5400, Redstone Arsenal, AL 35898 USA. NR 32 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0830-2 J9 AIP CONF PROC PY 2010 VL 1280 BP 130 EP + DI 10.1063/1.3507193 PG 3 WC Physics, Applied; Physics, Multidisciplinary SC Physics GA BTH72 UT WOS:000286947800014 ER PT J AU Choi, KK AF Choi, K. K. GP IEEE TI Corrugated Quantum Well Infrared Photodetectors SO 2010 23RD ANNUAL MEETING OF THE IEEE PHOTONICS SOCIETY LA English DT Proceedings Paper CT 23rd Annual Meeting of the IEEE Photonics-Society CY NOV 07-11, 2010 CL Denver, CO SP IEEE Photon Soc C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Choi, KK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. RI Choi, Kwong-Kit/K-9205-2013 NR 0 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5369-6 PY 2010 BP 641 EP 642 DI 10.1109/PHOTONICS.2010.5699051 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BTS83 UT WOS:000287997500323 ER PT B AU Ragsdale, RD Jacoby, GA AF Ragsdale, Roy D. Jacoby, Grant A. GP IEEE TI Photo-Trail: Building Eye-Level-View Enhanced Navigation Technology SO 2010 7TH IEEE CONSUMER COMMUNICATIONS AND NETWORKING CONFERENCE-CCNC 2010 SE IEEE Consumer Communications and Networking Conference LA English DT Proceedings Paper CT 7th IEEE Consumer Communications and Networking Conference CY JAN 09-12, 2010 CL Las Vegas, NV SP IEEE, Samsung, Nokia AB This paper describes how to provide an inexpensive capability that automatically captures, time-stamps, and geo-rectifies single and 360 degree-panoramic eye-level imagery while the image-taker freely moves around the environment. These same images readily overlay all virtual maps as icons to create photo-trails that can be queried, sorted, and expanded to help support planning for a variety of commercial, industrial, and military purposes. C1 [Ragsdale, Roy D.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10997 USA. RP Ragsdale, RD (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10997 USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-5175-3 J9 CONSUM COMM NETWORK PY 2010 BP 143 EP 147 PG 5 WC Computer Science, Information Systems; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BRI28 UT WOS:000282765100029 ER PT S AU Gupta, S Wallqvist, A Bondugula, R Ivanic, J Reifman, J AF Gupta, Shobhit Wallqvist, Anders Bondugula, Rajkumar Ivanic, Joseph Reifman, Jaques GP IEEE TI Unraveling the conundrum of seemingly discordant protein-protein interaction datasets SO 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 32nd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 10) CY AUG 30-SEP 04, 2010 CL Buenos Aires, ARGENTINA SP IEEE Engn Med & Biol Soc (EMBS) ID SACCHAROMYCES-CEREVISIAE; ESCHERICHIA-COLI; DATABASE; COMPLEXES AB Most high-throughput experimental results of protein-protein interactions (PPIs) are seemingly inconsistent with each other. In this article, we re-evaluated these contradictions within the context of the underlying domain-domain interactions (DDIs) for two Escherichia coli and four Saccharomyces cerevisiae PPI datasets derived from high-throughput (yeast two-hybrid and tandem affinity purification) experimental platforms. For shared DDIs across pairs of compared datasets, we observed a remarkably high pair-wise correlation (Pearson correlation coefficient between 0.80 and 0.84) between datasets of the same organism derived from the same experimental platform. To a lesser degree, this concordance also held true for more general inter-platform and intra-species comparisons (Pearson correlation coefficient between 0.52 and 0.89). Thus, although varying experimental conditions can influence the ability of individual proteins to interact and, therefore, create apparent differences among PPIs, the physical nature of the underlying interactions, captured by DDIs, is the same and can be used to model and predict PPIs. C1 [Gupta, Shobhit; Wallqvist, Anders; Bondugula, Rajkumar; Ivanic, Joseph; Reifman, Jaques] USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA. RP Reifman, J (reprint author), USA, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA. EM jaques.reifman@us.army.mil OI wallqvist, anders/0000-0002-9775-7469 NR 18 TC 4 Z9 4 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4124-2 J9 IEEE ENG MED BIO PY 2010 BP 783 EP 786 DI 10.1109/IEMBS.2010.5626490 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BTS36 UT WOS:000287964001047 ER PT S AU Aletti, F Chen, XX Sala-Mercado, JA Hammond, RL O'Leary, DS Cerutti, S Baselli, G Mukkamala, R AF Aletti, Federico Chen, Xiaoxiao Sala-Mercado, Javier A. Hammond, Robert L. O'Leary, Donal S. Cerutti, Sergio Baselli, Giuseppe Mukkamala, Ramakrishna GP IEEE TI Identification of sources of low frequency variability of arterial blood pressure: cardiac output acts as a buffer and not as a source SO 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 32nd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 10) CY AUG 30-SEP 04, 2010 CL Buenos Aires, ARGENTINA SP IEEE Engn Med & Biol Soc (EMBS) ID OSCILLATIONS; DOGS AB Arterial blood pressure (ABP) short term variability is due to beat-by-beat fluctuations in cardiac output (CO) and total peripheral resistance (TPR), which have distinct effects at low and high frequencies. In particular, it was shown that CO is able to buffer TPR slow oscillations in the LF band, but it has not been addressed if CO can contribute to oscillations of ABP in this band. In this paper, we propose a model for the identification of ABP variability sources, in order to show evidence that CO fluctuations are not a source of ABP LF oscillations, but they only buffer ABP variability of vasomotor origin. C1 [Aletti, Federico] Politecn Milan, Dipartimento Bioingn, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy. [Chen, Xiaoxiao] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Bioinformat Cell, Ft Detrick, MD 21702 USA. [Sala-Mercado, Javier A.; Hammond, Robert L.; O'Leary, Donal S.] Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA. [Cerutti, Sergio; Baselli, Giuseppe] Politecn Milan, Dept Bioingn, Milan, Italy. [Mukkamala, Ramakrishna] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. RP Aletti, F (reprint author), Politecn Milan, Dipartimento Bioingn, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy. EM federico.aletti@polimi.it; xchen@bioanalysis.com; javosala@hotmail.com; robert.hammond@beaumont.edu; doleary@med.wayne.edu; sergio.cerutti@polimi.it; giuseppe.baselli@polimi.it; rama@egr.msu.edu NR 5 TC 2 Z9 2 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4124-2 J9 IEEE ENG MED BIO PY 2010 BP 3460 EP 3462 DI 10.1109/IEMBS.2010.5627826 PG 3 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BTS36 UT WOS:000287964003214 ER PT S AU Xu, D Ryan, KL Rickards, CA Zhang, GQ Convertino, VA Mukkamala, R AF Xu, Da Ryan, Kathy L. Rickards, Caroline A. Zhang, Guanqun Convertino, Victor A. Mukkamala, Ramakrishna GP IEEE TI Robust Pulse Wave Velocity Estimation by Application of System Identification to Proximal and Distal Arterial Waveforms SO 2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) SE IEEE Engineering in Medicine and Biology Society Conference Proceedings LA English DT Proceedings Paper CT 32nd Annual International Conference of the IEEE Engineering-in-Medicine-and-Biology-Society (EMBC 10) CY AUG 30-SEP 04, 2010 CL Buenos Aires, ARGENTINA SP IEEE Engn Med & Biol Soc (EMBS) ID TIME AB Pulse wave velocity (PWV) is a marker of arterial stiffness and may permit continuous, non-invasive, and cuff-less monitoring of blood pressure. Here, robust PWV estimation was sought by application of system identification to proximal and distal arterial waveforms. In this approach, the system that optimally couples the proximal waveform to the distal waveform is identified, and the time delay of this system is then used to calculate PWV. To demonstrate proof-of-concept, a standard identification technique was applied to non-invasive impedance cardiography and peripheral arterial blood pressure waveforms from six humans subjected to progressive reductions in central blood volume induced by lower body negative pressure. This technique estimated diastolic pressure with an overall root-mean-squared-error of 5.2 mmHg. For comparison, the conventional detection method for estimating PWV yielded a corresponding error of 8.3 mmHg. C1 [Xu, Da; Zhang, Guanqun; Mukkamala, Ramakrishna] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Ryan, Kathy L.; Convertino, Victor A.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Rickards, Caroline A.] Univ Texas San Antonio, San Antonio, TX 78249 USA. RP Xu, D (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. EM xuda@msu.edu; kathy.ryan@amedd.army.mil; caroline.rickards@us.army.mil; zhanggu2@msu.edu; victor.convertino@amedd.army.mil; rama@egr.msu.edu RI Xu, Da/A-6423-2012 FU NSF CAREER [0643477] FX This work was supported in part by the NSF CAREER Grant 0643477. NR 8 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1557-170X BN 978-1-4244-4124-2 J9 IEEE ENG MED BIO PY 2010 BP 3559 EP 3562 DI 10.1109/IEMBS.2010.5627718 PG 4 WC Engineering, Biomedical; Engineering, Electrical & Electronic SC Engineering GA BTS36 UT WOS:000287964003241 ER PT J AU Garrett, GA Shen, HG Wraback, M Grandusky, JR Gibb, S Schowalter, LJ AF Garrett, Gregory A. Shen, Hongen Wraback, Michael Grandusky, James R. Gibb, Shawn Schowalter, Leo J. GP IEEE TI Excitation Wavelength Dependence of Time-Resolved Photoluminescence in Deep-UV MQW LEDs on Bulk AlN SO 2010 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (QELS) LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO)/Quantum Electronics and Laser Science Conference (QELS) CY MAY 16-21, 2010 CL San Jose, CA AB Photoluminescence lifetimes of nearly dislocation free high Al content AlGaN MQW LEDs on bulk AlN are presented as a function of temperature and excitation power for both direct photo-excitation of the wells and barriers. (C) 2010 Optical Society of America C1 [Garrett, Gregory A.; Shen, Hongen; Wraback, Michael] USA, Sensors & Elect Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. [Grandusky, James R.; Gibb, Shawn; Schowalter, Leo J.] Crystal IS Inc, New York, NY 12183 USA. RP Garrett, GA (reprint author), USA, Sensors & Elect Devices Directorate, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gregory.a.garrett@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-55752-890-2 PY 2010 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BUW45 UT WOS:000290513601200 ER PT J AU Leisher, P Dong, WM Grimshaw, M DeFranza, M Dubinskii, M Patterson, S Martinsen, R AF Leisher, Paul Dong, Weimin Grimshaw, Mike DeFranza, Mark Dubinskii, Mark Patterson, Steve Martinsen, Rob GP IEEE TI 1500-nm InP Diode Lasers Optimized for Use at 77K Demonstrate 73% Conversion Efficiency SO 2010 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (QELS) LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO)/Quantum Electronics and Laser Science Conference (QELS) CY MAY 16-21, 2010 CL San Jose, CA ID TEMPERATURE-DEPENDENCE AB The power conversion efficiency of cryogenically-cooled InP diode lasers is limited by excess electrical voltage caused by carrier freeze-out. A laser design which specifically mitigates this effect demonstrates peak efficiency of 73% at 77K. (C) 2010 Optical Society of America C1 [Leisher, Paul; Dong, Weimin; Grimshaw, Mike; DeFranza, Mark; Patterson, Steve; Martinsen, Rob] nLight Corp, 5408 NE 88th St Bldg E, Vancouver, WA 98665 USA. [Dubinskii, Mark] Army Res Lab, Adelphi, MD 20783 USA. RP Leisher, P (reprint author), nLight Corp, 5408 NE 88th St Bldg E, Vancouver, WA 98665 USA. EM paul.leisher@nlight.net NR 8 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-55752-890-2 PY 2010 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BUW45 UT WOS:000290513601460 ER PT J AU Newburgh, GA Word-Daniels, A Ikesue, A Dubinskii, M AF Newburgh, G. A. Word-Daniels, Akil Ikesue, Akio Dubinskii, Mark GP IEEE TI Resonantly Pumped 2.1-mu m Ho:Y(2)O(3) Ceramic Laser SO 2010 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (QELS) LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO)/Quantum Electronics and Laser Science Conference (QELS) CY MAY 16-21, 2010 CL San Jose, CA AB We report the first Ho: Y(2)O(3) ceramic laser operating at 2.085 mu m with 29% slope efficiency as resonantly diode-pumped at 1.93 mu m. Pertinent spectroscopic data are also presented. (C) 2010 Optical Society of America C1 [Newburgh, G. A.; Word-Daniels, Akil; Dubinskii, Mark] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Newburgh, GA (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM gnewburgh@arl.army.mil NR 4 TC 0 Z9 0 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-55752-890-2 PY 2010 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BUW45 UT WOS:000290513600170 ER PT J AU Sanamyan, T Simmons, J Dubinskii, M AF Sanamyan, T. Simmons, J. Dubinskii, M. GP IEEE TI Efficient Cryo-Cooled 2.7-mu m Er(3+)-Doped Y(2)O(3) Ceramic Laser Diode-Pumped at 974 nm SO 2010 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (QELS) LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO)/Quantum Electronics and Laser Science Conference (QELS) CY MAY 16-21, 2010 CL San Jose, CA AB Reported here is the first cryogenically-cooled diode-pumped performance of Er(3+):Y(2)O(3) laser based on (4)I(11/2) double right arrow (4)I(13/2) transitions. Pump-limited CW power of over 1.6 W at similar to 2.7 mu m was achieved with the 27.5% slope efficiency. (C) 2010 Optical Society of America C1 [Sanamyan, T.; Simmons, J.; Dubinskii, M.] USA, Res Lab, RDRL SEE O, Adelphi, MD 20783 USA. RP Sanamyan, T (reprint author), USA, Res Lab, RDRL SEE O, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mdubinskiy@arl.army.mil NR 9 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-55752-890-2 PY 2010 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BUW45 UT WOS:000290513600174 ER PT J AU Shatalov, M Sun, W Yang, J Hu, X Bilenko, Y Gaska, R Moe, CG Wraback, M AF Shatalov, M. Sun, W. Yang, J. Hu, X. Bilenko, Yu Gaska, R. Moe, C. G. Wraback, M. GP IEEE TI High Power 245 nm Deep UV LEDs SO 2010 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO) AND QUANTUM ELECTRONICS AND LASER SCIENCE CONFERENCE (QELS) LA English DT Proceedings Paper CT Conference on Lasers and Electro-Optics (CLEO)/Quantum Electronics and Laser Science Conference (QELS) CY MAY 16-21, 2010 CL San Jose, CA AB We report large area, 245 nm to 250 nm deep UV LEDs with output power more than 5 mW in CW operation and above 30 mW for 200 mu s pulses at 10 % duty cycle. C1 [Shatalov, M.; Sun, W.; Yang, J.; Hu, X.; Bilenko, Yu; Gaska, R.] Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA. [Moe, C. G.; Wraback, M.] Army Res Lab, Adelphi, MD 20783 USA. RP Shatalov, M (reprint author), Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA. EM shatalov@s-et.com NR 5 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-55752-890-2 PY 2010 PG 2 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA BUW45 UT WOS:000290513601198 ER PT J AU Hung, HA AF Hung, H. Alfred GP IEEE TI Advances in Millimeter-wave and Sub-millimeter-wave Devices and Circuits, Si to III-Vs SO 2010 EUROPEAN MICROWAVE INTEGRATED CIRCUITS CONFERENCE (EUMIC) SE European Microwave Integrated Circuits Conference - Proceedings LA English DT Proceedings Paper CT Conference on European Microwave Week Connecting the World CY SEP 26-OCT 01, 2010 CL Paris, FRANCE SP IEEE, EuMA, EurAAP, IET AB This paper addresses the recent advances in InP-, GaN-, and Si/SiGe-based devices, monolithic integrated circuits, and subsystem integration at millimeter-wave (mmW) and sub-millimeter-wave (sub-mmW) frequencies. Current performance status and limitations, and future trend of technology development will be presented. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Hung, HA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM hahung@alum.mit.edu NR 0 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-2-87487-017-0 J9 EUR MICROW INTEGRAT PY 2010 BP 73 EP 73 PG 1 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTU72 UT WOS:000288124400019 ER PT J AU Darwish, AM Hung, HA AF Darwish, Ali M. Hung, H. Alfred GP IEEE TI Dependence of FET/HEMT Reliability on Substrate Thickness and Gate Length SO 2010 EUROPEAN MICROWAVE INTEGRATED CIRCUITS CONFERENCE (EUMIC) SE European Microwave Integrated Circuits Conference - Proceedings LA English DT Proceedings Paper CT Conference on European Microwave Week Connecting the World CY SEP 26-OCT 01, 2010 CL Paris, FRANCE SP IEEE, EuMA, EurAAP, IET AB The transistor substrate has a significant role on RF losses, device heating, and reliability. The substrate thickness, and the gate length, among other parameters, have direct implications on the transistor lifetime. This paper presents an analytical expression relating the reliability to gate length and to substrate thickness for a field effect transistor (FET), or a high electron mobility transistor (HEMT), based on thermal considerations. Experimental observations support the model's predicted results. The derived methodology and analytical expressions are useful for device/MMIC designers to assess the device/circuit reliability performance. C1 [Darwish, Ali M.; Hung, H. Alfred] USA, Res Lab, RF Elect Dept, Adelphi, MD 20783 USA. RP Darwish, AM (reprint author), USA, Res Lab, RF Elect Dept, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM adarwish@aucegypt.edu; ahung@arl.army.mil NR 10 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-2-87487-017-0 J9 EUR MICROW INTEGRAT PY 2010 BP 262 EP 265 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTU72 UT WOS:000288124400068 ER PT J AU Cheoki, KC Radovnikovichi, M Vempaty, PK Hudas, GR Overholt, JL Fleck, P AF Cheoki, Ka C. Radovnikovichi, M. Vempaty, P. K. Hudas, G. R. Overholt, J. L. Fleck, Paul GP IEEE TI UWB Tracking of Mobile Robots SO 2010 IEEE 21ST INTERNATIONAL SYMPOSIUM ON PERSONAL INDOOR AND MOBILE RADIO COMMUNICATIONS (PIMRC) LA English DT Proceedings Paper CT 21st Annual IEEE International Symposium on Personal, Indoor and Mobile Radio Communications (PIMRC) CY SEP 26-30, 2010 CL Istanbul, TURKEY SP IEEE DE UItra-wideband (UWB); local positioning system (LPS); mobile robot; multi-paths; fuzzy neighborhood filter; progressive update; trilateration; validation; ground truth AB A local positioning system (LPS) for tracking mobile robots using a newly developed uItra-wideband (UWB) ranging radio technology is presented in this paper. However, measured ranges from these radios often have uncertain biases and large sporadic errors due to multipath and attenuation effect. A fuzzy neighborhood tracking filtering technique was developed to deal with the range outlier problems. A progressive update trilateration filter technique is introduced. The paper then describes a UWB LPS based on triangulation or trilateration of the ranges, which is fused with other vehicle kinematics/dynamics sensors including a compass, rate gyros and wheel speed sensors. The UWB LPS was applied to navigation and guidance of an experimental autonomous mobile robot. Simulation theoretical and real-time experimental results were validated against the true results of the experiment recorded by video. C1 [Cheoki, Ka C.; Radovnikovichi, M.; Vempaty, P. K.] Oakland Univ, Dept Elect & Comp Engn, Rochester, MI 48309 USA. [Hudas, G. R.; Overholt, J. L.] US Army TARDEC, Joint Ctr Robot, Warren, MI 48397 USA. [Fleck, Paul] Dataspeed Inc, Troy, MI 48085 USA. RP Cheoki, KC (reprint author), Oakland Univ, Dept Elect & Comp Engn, Rochester, MI 48309 USA. FU US Army TARDEC FX this research is sponsored by the Joint Center for Robotics of the US Army TARDEC NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-8016-6 PY 2010 BP 2615 EP 2620 DI 10.1109/PIMRC.2010.5671780 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BAW81 UT WOS:000305822600465 ER PT S AU Coburn, WO Anthony, TK Zaghloul, AI AF Coburn, W. O'Keefe Anthony, T. K. Zaghloul, A. I. GP IEEE TI Open-Ended Waveguide Radiation Characteristics - Full-Wave Simulation versus Analytical Solutions SO 2010 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT 2010 IEEE International Symposium Antennas and Propagation/CNC-USNC/URSI Radio Science Meeting CY JUL 11-17, 2010 CL Toronto, CANADA SP IEEE, URSI C1 [Coburn, W. O'Keefe; Anthony, T. K.; Zaghloul, A. I.] USA, Res Lab, Adelphi, MD 20783 USA. RP Coburn, WO (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM keefe.coburn@us.army.mil; theodore.anthony@us.army.mil; amir.zaghloul@us.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4244-4968-2 J9 IEEE ANTENNAS PROP PY 2010 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTL34 UT WOS:000287212400072 ER PT S AU Katulka, G Hall, R AF Katulka, Gary Hall, Rex GP IEEE TI Electro-dynamic analysis of 60mm mortars modified with Guidance, Navigation, and Control components SO 2010 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT 2010 IEEE International Symposium Antennas and Propagation/CNC-USNC/URSI Radio Science Meeting CY JUL 11-17, 2010 CL Toronto, CANADA SP IEEE, URSI AB This paper summarizes the results from numerical analyses of 60mm mortar projectile bodies that are modified with guidance, navigation, and control (GNC) hardware. The major findings from the study include: 1) the far field radiation patterns predicted for the projectile considered in this analysis are sensitive to the overall size and shape of the projectile flight body, specifically shorter projectile structures tend to radiate more energy in the transverse flight direction, and 2) some electrical characteristics such as the voltage standing wave ratio (VSWR), characteristic impedance (Zo), and the return loss, as seen from the embedded GNC antenna are sensitive to the projectile body size and shape, also shorter projectile structures appear to have lower resonant frequency given the same GNC antenna configuration. The numerical simulations are validated with experimental measurement data obtained from the anechoic chamber. This was true for VSWR, S11 and characteristic impedance data, as well as the far field radiation pattern characteristics. C1 [Katulka, Gary; Hall, Rex] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Katulka, G (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM Gary.Katulka@us.army.mil NR 6 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4244-4968-2 J9 IEEE ANTENNAS PROP PY 2010 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTL34 UT WOS:000287212400040 ER PT S AU Keller, SD Weiss, S AF Keller, Steven D. Weiss, Steven GP IEEE TI Microstrip Patch Antenna Array for a Scalable X-band Radar System SO 2010 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT 2010 IEEE International Symposium Antennas and Propagation/CNC-USNC/URSI Radio Science Meeting CY JUL 11-17, 2010 CL Toronto, CANADA SP IEEE, URSI C1 [Keller, Steven D.; Weiss, Steven] USA, Res Lab, Adelphi, MD 20783 USA. RP Keller, SD (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM steven.keller4@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4244-4968-2 J9 IEEE ANTENNAS PROP PY 2010 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTL34 UT WOS:000287212400048 ER PT S AU Le, C Nguyen, L Dogaru, T AF Le, Calvin Lam Nguyen Dogaru, Traian GP IEEE TI Radar Imaging of a Large Building Based on Near-Field Xpatch Model SO 2010 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT 2010 IEEE International Symposium Antennas and Propagation/CNC-USNC/URSI Radio Science Meeting CY JUL 11-17, 2010 CL Toronto, CANADA SP IEEE, URSI AB The U.S. Army Research Laboratory's ultra-wideband (UWB) radar was used in field experiments for through-the-wall imaging of an abandoned Army barrack with an approximate 33 m by 27 m footprint. In a previous paper, we used a Physical Optics (PO) based ray tracing code simulating a far-field spotlight configuration in order to explain some scattering features observed in the experimental image (obtained via near-field strip-map configuration). In this paper, we use the same code and model for a data collection geometry that closely matches the experimental setup, and the backprojection algorithm (BPA) for image formation. The new simulated image shows an improved correlation with the measured image, further confirming the applicability of ray tracing codes for UWB imaging in a realistic environment. C1 [Le, Calvin; Lam Nguyen; Dogaru, Traian] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RP Le, C (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM calvin.le@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4244-4968-2 J9 IEEE ANTENNAS PROP PY 2010 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTL34 UT WOS:000287212403230 ER PT S AU Palreddy, S Zaghloul, AI Cheung, R AF Palreddy, Sandeep Zaghloul, Amir I. Cheung, Rudolf GP IEEE TI An Optimized Lossy Back Cavity Loaded Four Arm Sinuous Antenna SO 2010 IEEE ANTENNAS AND PROPAGATION SOCIETY INTERNATIONAL SYMPOSIUM SE IEEE Antennas and Propagation Society International Symposium LA English DT Proceedings Paper CT 2010 IEEE International Symposium Antennas and Propagation/CNC-USNC/URSI Radio Science Meeting CY JUL 11-17, 2010 CL Toronto, CANADA SP IEEE, URSI C1 [Palreddy, Sandeep; Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Blacksburg, VA 22043 USA. [Palreddy, Sandeep; Cheung, Rudolf] Microwave Engn Corp, N Andover, MA 01845 USA. [Zaghloul, Amir I.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Palreddy, S (reprint author), Virginia Polytech Inst & State Univ, Blacksburg, VA 22043 USA. EM s_palreddy@microwaveeng.com; r_cheung@microwaveeng.com; amirz@vt.edu NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-3965 BN 978-1-4244-4968-2 J9 IEEE ANTENNAS PROP PY 2010 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTL34 UT WOS:000287212402008 ER PT S AU Keyler, M AF Keyler, M. GP IEEE TI TPS transportability in windows environment SO 2010 IEEE AUTOTESTCON SE IEEE Autotestcon LA English DT Proceedings Paper CT AUTOTESTCON 2010 Systems Readiness Technology Conference CY SEP 13-16, 2010 CL Orlando, FL AB This paper describes implementation of software components that allow Visual Basic Test Program Sets (TPSs) to be transportable in different windows environments. Streamlined implementation of these components with regard to backward compatibility ensures transparency to the TPS developer. There is an intermediate layer that exists on all TETS, a United States Marine Corps (USMC) Automated Test Equipment (ATE), called the Test Program Executive, which takes in inputs from the TPS and translates these into VISA layer calls that talk directly to the ATE instrumentation. The Test Executive in combination with other system components should allow for TPS Engineer transparency when designing TPSs for different windows systems. This method of making TPS transportable is preferred to using a 1641-like option. C1 USA, Automated Test Syst Div, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07801 USA. RP Keyler, M (reprint author), USA, Automated Test Syst Div, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07801 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-7959-7 J9 IEEE AUTOTESTCON PY 2010 BP 68 EP 72 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BTI75 UT WOS:000287044100014 ER PT S AU Carey, DR Dewey, M AF Carey, David R. Dewey, Michael GP IEEE TI Modernizing Legacy Automated Test Systems for DoD Depots SO 2010 IEEE AUTOTESTCON SE IEEE Autotestcon LA English DT Proceedings Paper CT AUTOTESTCON 2010 Systems Readiness Technology Conference CY SEP 13-16, 2010 CL Orlando, FL DE legacy test system; TPS; depot test sysetms; automated test systems AB Department of defense (DoD) maintenance depots face a growing challenge regarding legacy Automated Test Systems (ATS). These systems, which are critical to ensuring mission success, are increasingly difficult to maintain and repair as well as being costly to modernize or replace. According to the General Accounting Office, the DoD has estimated that they will spend billions of dollars to modernize their ATS inventory, much of which was acquired in the 1970s and 1980s [1]. One of the maintenance depots is Tobyhanna Army Depot (TYAD) and is in a similar situation with it legacy test systems. The aging testers at TYAD are becoming increasingly out of date and more difficult to support. When the testers do not work properly, maintenance can suffer and readiness can be adversely affected. This paper reviews the requirements and issues associated with depot ATS equipment and will present a technical strategy for the modernization of ATS at TYAD. C1 [Carey, David R.] USA, Tobyhanna Army Depot, Test Program Dev Branch, Tobyhanna, PA 18466 USA. RP Carey, DR (reprint author), USA, Tobyhanna Army Depot, Test Program Dev Branch, Tobyhanna, PA 18466 USA. EM david.r.carey@us.army.mil; miked@geotestinc.com NR 3 TC 0 Z9 0 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-7959-7 J9 IEEE AUTOTESTCON PY 2010 BP 90 EP 95 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA BTI75 UT WOS:000287044100019 ER PT S AU Carey, DR AF Carey, David R. GP IEEE TI Tobyhanna Army Depot Automated Test System Modernization SO 2010 IEEE AUTOTESTCON SE IEEE Autotestcon LA English DT Proceedings Paper CT AUTOTESTCON 2010 Systems Readiness Technology Conference CY SEP 13-16, 2010 CL Orlando, FL DE component; Modernization; Legacy; ATS Policy; NGATS; VDATS AB During the last four decades the number of Automated Test Systems (ATS) has experienced tremendous growth at Tobyhanna Army Depot (TYAD). This is characterized in the proliferation through Base Realignment and Closure acquisition and in-house development of a wide variety of general and special purpose ATS - to date there are 94 unique ATS and a total of 230 ATS. With advancing technology and increasingly complex electronic systems, unique ATS has become a problem of maintenance test strategies at the depot; given the high costs of modernizing or replacing ATS and its potential effect on meeting mission success requirements. The aging testers at TYAD are becoming increasingly out of date and more difficult to support. When the testers do not work properly, maintenance can suffer and mission readiness can be adversely affected. This paper will analyze the problem and present a plan for modernization of ATS at TYAD that satisfies Army Regulation, AR750-43, and DOD ATS acquisition policy. C1 USA, Tobyhanna Army Depot, Test Program Dev Branch, Tobyhanna, PA 18466 USA. RP Carey, DR (reprint author), USA, Tobyhanna Army Depot, Test Program Dev Branch, Tobyhanna, PA 18466 USA. EM david.r.carey@us.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-7959-7 J9 IEEE AUTOTESTCON PY 2010 BP 101 EP 105 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BTI75 UT WOS:000287044100021 ER PT S AU Lospinuso, M Marston, D Gearhart, S AF Lospinuso, Mike Marston, Derek Gearhart, Scott GP IEEE TI State Configuration Controller for Network Centric Organizational At-System Level Testing SO 2010 IEEE AUTOTESTCON SE IEEE Autotestcon LA English DT Proceedings Paper CT AUTOTESTCON 2010 Systems Readiness Technology Conference CY SEP 13-16, 2010 CL Orlando, FL C1 [Lospinuso, Mike; Marston, Derek; Gearhart, Scott] USA, Picatinny Arsenal, Automated Test Syst Div, Picatinny Arsenal, NJ 07806 USA. RP Lospinuso, M (reprint author), USA, Picatinny Arsenal, Automated Test Syst Div, Picatinny Arsenal, NJ 07806 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1088-7725 BN 978-1-4244-7959-7 J9 IEEE AUTOTESTCON PY 2010 BP 400 EP 404 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BTI75 UT WOS:000287044100081 ER PT S AU Bluman, J Rowland, M Mockensturm, E AF Bluman, James Rowland, Matthew Mockensturm, Eric GP IEEE TI Closing the Homework Feedback Loop, an Alternative Approach to Homework Grading SO 2010 IEEE FRONTIERS IN EDUCATION CONFERENCE (FIE) SE Frontiers in Education Conference LA English DT Proceedings Paper CT 40th Annual Frontiers in Education Conference CY OCT 27-30, 2010 CL Arlington, VA SP IEEE DE Grading Methods; Student Motivation; Error Feedback; Improved Learning AB This paper studies an alternative grading method for homework assignments designed to increase student learning and motivation. The method emphasizes correct completion of student work, even if multiple turn-ins are required. After submitting homework, the instructor checks the accuracy of the work. Incorrect work is returned to the students the morning after its initial due date. Students are then given a day or two to correct their work and re-submit. This cycle is repeated as many times as necessary at the teacher's discretion. Grades are based on the number of iterations required for the work to be correct. Results from the study show that while student learning was not measurably affected, student motivation to perform well on the homework assignments increased. This rise in motivation may be dependent on the context within which the method is employed-it seems to work better for higher level technical electives than for larger common courses. C1 [Bluman, James; Rowland, Matthew] US Mil Acad, West Point, NY USA. [Mockensturm, Eric] Penn State Univ, University Pk, PA 16802 USA. EM james.bluman@usma.edu; matthew.rowland@usma.edu; emm10@psu.edu NR 9 TC 0 Z9 0 U1 1 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0190-5848 BN 978-1-4244-6259-9 J9 PROC FRONT EDUC CONF PY 2010 PG 6 WC Education & Educational Research; Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA BTJ30 UT WOS:000287083200127 ER PT S AU Chen, IR Bao, F Chang, M Cho, JH AF Chen, Ing-Ray Bao, Fenye Chang, Moonjeong Cho, Jin-Hee GP IEEE TI Trust Management for Encounter-Based Routing in Delay Tolerant Networks SO 2010 IEEE GLOBAL TELECOMMUNICATIONS CONFERENCE GLOBECOM 2010 SE IEEE Global Telecommunications Conference (Globecom) LA English DT Proceedings Paper CT IEEE Global Telecommunications Conference (GLOBECOM 2010) CY DEC 06-10, 2010 CL Miami, FL SP IEEE DE Delay tolerant networks; opportunistic routing; social trust; QoS trust; social networks; performance analysis; stochastic Petri nets ID DTNS AB We propose and analyze a class of trust management protocols for encounter-based routing in delay tolerant networks (DTNs). The underlying idea is to incorporate trust evaluation in the routing protocol, considering not only quality-of-service (QoS) trust properties (connectivity) but also social trust properties (honesty and unselfishness) to evaluate other nodes encountered. Two versions of trust management protocols are considered: an equal-weight QoS and social trust management protocol (called trust-based routing) and a QoS only trust management protocol (called connectivity-based routing). By utilizing a stochastic Petri net model describing a DTN behavior, we analyze the performance characteristics of these two routing protocols in terms of message delivery ratio, latency, and message overhead. We also perform a comparative performance analysis with epidemic routing for a DTN consisting of heterogeneous mobile nodes with vastly different social and networking behaviors. The results indicate that trust-based routing approaches the ideal performance of epidemic routing in delivery ratio, while connectivity-based routing approaches the ideal performance in message delay of epidemic routing, especially as the percentage of selfish and malicious nodes present in the DTN system increases. By properly selecting weights associated with QoS and social trust metrics for trust evaluation, our trust management protocols can approximate the ideal performance obtainable by epidemic routing in delivery ratio and message delay without incurring high message overhead. C1 [Chen, Ing-Ray; Bao, Fenye; Chang, Moonjeong] Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. [Cho, Jin-Hee] US Army, Res Lab, Computat & Informat Sci, Adelphi, MD USA. RP Chen, IR (reprint author), Virginia Tech, Dept Comp Sci, Blacksburg, VA 24061 USA. EM irchen@vt.edu; baofenye@vt.edu; mjchang@vt.edu; jinhee.cho@us.army.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-529X BN 978-1-4244-5638-3 J9 GLOB TELECOMM CONF PY 2010 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTS42 UT WOS:000287977400157 ER PT S AU Lai, HQ Gao, ZZ Liu, KJR AF Lai, Hung-Quoc Gao, Zhenzhen Liu, K. J. Ray GP IEEE TI Space-Time Network Codes Utilizing Transform-Based Coding SO 2010 IEEE GLOBAL TELECOMMUNICATIONS CONFERENCE GLOBECOM 2010 SE IEEE Global Telecommunications Conference (Globecom) LA English DT Proceedings Paper CT IEEE Global Telecommunications Conference (GLOBECOM 2010) CY DEC 06-10, 2010 CL Miami, FL SP IEEE ID WIRELESS NETWORKS; COOPERATIVE DIVERSITY; PERFORMANCE; PROTOCOLS; CHANNELS; SCHEMES; SYSTEMS AB Cooperative communications can be used to improve communication reliability. However, the transmissions from different relaying nodes result in a great challenge in practice. The use of TDMA for relaying transmissions causes large transmission delay. In contrast, FDMA and CDMA associate with the issue of imperfect frequency and timing synchronization due to the simultaneous transmissions from the relaying nodes. In this work, we propose a space-time network coding (STNC) scheme utilizing transform-based coding to improve communication reliability while maintaining a stable network throughput and overcoming the issue of imperfect frequency and timing synchronization. Based on TDMA, a node in the network forms a linearly-coded signal from the overheard symbols and transmits it to the destination in its dedicated time slot. The pairwise error probability (PEP) is analyzed and design criteria of the STNC are derived to ensure achieving full diversity. Simulations are conducted to verify the performance of the proposed scheme and to reveal its advantage over a distributed space-time block coding scheme under timing synchronization errors. C1 [Lai, Hung-Quoc] USA, RDECOM CERDEC, RDER STW N, Aberdeen Proving Ground, MD 21005 USA. [Lai, Hung-Quoc; Gao, Zhenzhen; Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Gao, Zhenzhen] Xi An Jiao Tong Univ, Dept Informat & Commun Engn, Xian 710049, Peoples R China. RP Lai, HQ (reprint author), USA, RDECOM CERDEC, RDER STW N, Aberdeen Proving Ground, MD 21005 USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-529X BN 978-1-4244-5638-3 J9 GLOB TELECOMM CONF PY 2010 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTS42 UT WOS:000287977403141 ER PT S AU Drost, RJ Sadler, BM AF Drost, Robert J. Sadler, Brian M. GP IEEE TI Constellation Design for Color-Shift Keying Using Billiards Algorithms SO 2010 IEEE GLOBECOM WORKSHOPS SE IEEE Globecom Workshops LA English DT Proceedings Paper CT Globecom Workshops CY DEC 05-10, 2010 CL Miami, FL AB Light-emitting diodes (LEDs) have the potential to replace traditional devices in a variety of lighting applications, offering the possibility of simultaneous modulation for communications. One modulation method, color-shift keying (CSK), has been recently proposed specifically for red/green/blue (RGB) LEDs. We examine the design of CSK signaling constellations for an additive white Gaussian noise channel, incorporating the common requirement that the RGB LED outputs a specific, possibly time-varying, perceived color. In particular, we equate this design problem to that of disk packing and employ modified billiards algorithms that rely on the "thermodynamic" settling of the disks to obtain constellation points with good minimum distance. Simulation results are presented that illustrate the design approach. C1 [Drost, Robert J.; Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Drost, RJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM robert.drost@us.army.mil; brian.sadler@us.army.mil NR 8 TC 28 Z9 28 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2166-0069 BN 978-1-4244-8865-0 J9 IEEE GLOBE WORK PY 2010 BP 980 EP 984 DI 10.1109/GLOCOMW.2010.5700472 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BVI32 UT WOS:000291611300185 ER PT S AU Wang, LJ Li, YY Xu, ZY Sadler, BM AF Wang, Leijie Li, Yiyang Xu, Zhengyuan Sadler, Brian M. GP IEEE TI Wireless Ultraviolet Network Models and Performance in Noncoplanar Geometry SO 2010 IEEE GLOBECOM WORKSHOPS SE IEEE Globecom Workshops LA English DT Proceedings Paper CT Globecom Workshops CY DEC 05-10, 2010 CL Miami, FL DE Non-line-of-sight; ultraviolet; noncoplanar geometry; full-duplex; UV network ID AD-HOC NETWORKS; TRANSMISSION CAPACITY; COMMUNICATION LINKS; INTERFERENCE; CHANNEL; OUTAGE AB Atmospheric scattering for ultraviolet signals enables non-line-of-sight communication of a transmitter-receiver pair on-the-move and adaptive network configuration. In this work, we first develop an experimentally validated path loss model which characterizes both multiple scattering and arbitrary pointing with noncoplanar geometry. Then we discuss how to achieve full duplexing. We suggest transmission throughput as a metric to evaluate the performance of a wireless network consisting of randomly distributed nodes operating in such a channel. We further study the effects of some key network parameters including node spatial density, transmission probability and signal detection threshold via the lower bound of the transmission throughput. Performance optimization in the parameter space is performed numerically and simulation results are demonstrated. C1 [Wang, Leijie; Li, Yiyang; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] US Army, Res Lab, RDRL CIN, Adelphi, MD 20783 USA. RP Wang, LJ (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu; brian.sadler@us.army.mil FU Army Research Office [W911NF-08-1-0163, W911NF-09-1-0293]; Army Research Laboratory under the Collaborative Technology Alliance Program [DAAD19-01-2-0011] FX This work was supported in part by the Army Research Office under Grants W911NF-08-1-0163 and W911NF-09-1-0293, and the Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 20 TC 7 Z9 7 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2166-0069 BN 978-1-4244-8865-0 J9 IEEE GLOBE WORK PY 2010 BP 1037 EP 1041 DI 10.1109/GLOCOMW.2010.5700091 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BVI32 UT WOS:000291611300196 ER PT S AU Thompson, CC Hale, PS Arno, RG AF Thompson, Christopher C. Hale, Peyton S., Jr. Arno, Robert G. GP IEEE TI Decanting the Data: The Gold Book Presents Equipment Reliability Refreshment SO 2010 IEEE INDUSTRIAL AND COMMERCIAL POWER SYSTEMS TECHNICAL CONFERENCE SE IEEE Industrial and Commercial Power Systems and Technical Conference LA English DT Proceedings Paper CT 2010 IEEE Industrial and Commercial Power Systems Technical Conference CY MAY 09-13, 2010 CL Tallahassee, FL SP IEEE AB Since the last publication of the Gold Book, a team of engineers and statisticians has been pouring over a mountain of data through a public-private partnership. This effort has compressed equipment reliability data from 223 sites - hospitals, utility plants, universities, and the like. This paper discusses the major results of the effort, the quantity of data extracted, and the process of incorporation into the existing IEEE database. C1 [Thompson, Christopher C.; Hale, Peyton S., Jr.] US Army Corps Engn, Special Missions Off, PREP, 10115 Gridley Rd, Ft Belvoir, VA 22060 USA. [Arno, Robert G.] HP Crit Facil Serv, Albany, NY 12207 USA. RP Thompson, CC (reprint author), US Army Corps Engn, Special Missions Off, PREP, 10115 Gridley Rd, Ft Belvoir, VA 22060 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2163-9604 BN 978-1-4244-5601-7 J9 IND COMMER POWER PY 2010 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA BTN63 UT WOS:000287410700016 ER PT S AU Sadler, BM Liu, N Xu, ZY AF Sadler, Brian M. Liu, Ning Xu, Zhengyuan GP IEEE TI ZIV-ZAKAI BOUNDS FOR TIME DELAY ESTIMATION WITH FREQUENCY HOPPING AND MULTICARRIER SIGNALS IN WIDEBAND RANDOM CHANNELS SO 2010 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 14-19, 2010 CL Dallas, TX SP IEEE Signal Proc Soc DE Time delay estimation; Ziv-Zakai bound; multicarrier; frequency hopping; wideband channel; frequency-selective fading ID PARAMETER-ESTIMATION AB We develop Ziv-Zakai bounds (ZZBs) on time delay estimation (TDE) for known frequency hopping or multicarrier waveforms over random wideband (frequency selective) Gaussian channels, with a uniform prior on the delay. The channel model incorporates correlation, for example between subcarriers. A unified signal model is applicable to several cases of interest. The receiver does not have channel state information to estimate the time delay, but does have knowledge of the channel statistics. The ZZB provides a tight bound on the mean square error for Bayesian estimation in wideband random channels, revealing SNR threshold behavior indicating estimator breakdown. C1 [Sadler, Brian M.] Army Res Lab, Adelphi, MD 20783 USA. RP Sadler, BM (reprint author), Army Res Lab, Adelphi, MD 20783 USA. EM bsadler@arl.army.mil; dxu@ee.ucr.edu NR 12 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 BN 978-1-4244-4296-6 J9 INT CONF ACOUST SPEE PY 2010 BP 2570 EP 2573 DI 10.1109/ICASSP.2010.5496276 PG 4 WC Acoustics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Acoustics; Computer Science; Engineering GA BTJ55 UT WOS:000287096002130 ER PT S AU Ash, JN Whipps, GT Kozick, RJ AF Ash, Joshua N. Whipps, Gene T. Kozick, Richard J. GP IEEE TI PERFORMANCE OF SHOCKWAVE-BASED SHOOTER LOCALIZATION UNDER MODEL MISSPECIFICATION SO 2010 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 10-19, 2010 CL Dallas, TX SP IEEE Signal Proc Soc DE Shooter localization; Shockwave; Biased estimator; Misspecified model AB This paper considers the estimation of shooter locations using a sensor network where each sensor measures the time difference between receptions of a firearm's muzzle blast and a bullet's shockwave. This recently proposed approach has the advantages of reduced hardware complexity and not requiring time synchronization between sensors. The disadvantages are increased computational complexity and a requirement to know the bullet's velocity at all points along the trajectory. This paper proposes to eliminate these disadvantages by intentionally adopting an incorrect model that assumes a constant bullet velocity. The model misspecification naturally induces bias in subsequent maximum likelihood estimates (MLEs). We explore the performance impact of the model misspecification through analytical derivation of the bias and variance of the pseudo MLE. The analytic results are applied to several realistic firearm models and corroborated with simulations. C1 [Ash, Joshua N.] Ohio State Univ, ECE Dept, Columbus, OH 43210 USA. [Whipps, Gene T.] US Army Res Lab, Adelphi, MD USA. [Kozick, Richard J.] Bucknell Univ, Dept EEE, Lewisburg, PA USA. RP Ash, JN (reprint author), Ohio State Univ, ECE Dept, Columbus, OH 43210 USA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 BN 978-1-4244-4296-6 J9 INT CONF ACOUST SPEE PY 2010 BP 2694 EP 2697 DI 10.1109/ICASSP.2010.5496239 PG 4 WC Acoustics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Acoustics; Computer Science; Engineering GA BTJ55 UT WOS:000287096002161 ER PT S AU Nguyen, LH Tran, TD AF Nguyen, Lam H. Tran, Trac D. GP IEEE TI A SPARSITY-DRIVEN JOINT IMAGE REGISTRATION AND CHANGE DETECTION TECHNIQUE FOR SAR IMAGERY SO 2010 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 10-19, 2010 CL Dallas, TX SP IEEE Signal Proc Soc DE image registration; change detection; synthetic aperture radar (SAR); sparse representation; compressed sensing AB This paper presents a novel Sparsity-driven joint Image REgistration and Change Detection (SIRE-CD) technique for SAR imagery. The proposed algorithm simultaneously performs two main tasks: (i) locally register the test and reference images; and (ii) perform the change detection between the two. The key innovative concept here is the sparsity-driven transformation of the signatures from the reference image to match to those of the test image at the local image patch level. In other words, we are constructing a large dictionary from the reference data and use that to find the sparsest representation that best approximates the new incoming test data. The accuracy level of the approximation determines the detected changes between the reference and the test image. We demonstrate the performance of this technique using both simulated data and real SAR imagery from the Army Research Laboratory ultra-wideband (UWB) SAR forward-looking radar. C1 [Nguyen, Lam H.] USA, Res Lab, Adelphi, MD 20783 USA. [Tran, Trac D.] Johns Hopkins Univ, Baltimore, MD 21218 USA. RP Nguyen, LH (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 9 TC 4 Z9 4 U1 0 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 BN 978-1-4244-4296-6 J9 INT CONF ACOUST SPEE PY 2010 BP 2798 EP 2801 DI 10.1109/ICASSP.2010.5496197 PG 4 WC Acoustics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Acoustics; Computer Science; Engineering GA BTJ55 UT WOS:000287096002187 ER PT S AU Lai, HQ Liu, KJR AF Lai, Hung-Quoc Liu, K. J. Ray GP IEEE TI MULTIPOINT-TO-POINT AND POINT-TO-MULTIPOINT SPACE-TIME NETWORK CODING SO 2010 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 10-19, 2010 CL Dallas, TX SP IEEE Signal Proc Soc DE Space-time network coding; cooperative communications; frequency synchronization; timing synchronization ID WIRELESS NETWORKS; COOPERATIVE COMMUNICATIONS; PERFORMANCE ANALYSIS; DIVERSITY; PROTOCOLS AB Traditional cooperative communications can improve communication reliability. However, the simultaneous transmissions from multiple relays are challenging in practice due to the issue of imperfect frequency and timing synchronization. In this work, we propose space-time network codes (STNCs) that overcome the issue of imperfect synchronization, reduce the large transmission delay, and still provide full spatial diversity in multipoint-to-point (M2P) and point-to-multipoint (P2M) transmissions. Relays form single linearly-coded signals from the overheard symbols and transmit them to the destination, where multiuser detection is utilized to detect the desired symbol. For a network of N client nodes, M2P and P2M STNCs result in a diversity order of N with only 2N time slots, a significant reduction from N-2 time slots in traditional cooperative communications using TDMA. C1 [Lai, Hung-Quoc] USA, RDECOM CERDEC, RDER STW N, Aberdeen Proving Ground, MD 21005 USA. [Lai, Hung-Quoc; Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. RP Lai, HQ (reprint author), USA, RDECOM CERDEC, RDER STW N, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 0 Z9 1 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 BN 978-1-4244-4296-6 J9 INT CONF ACOUST SPEE PY 2010 BP 2878 EP 2881 DI 10.1109/ICASSP.2010.5496166 PG 4 WC Acoustics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Acoustics; Computer Science; Engineering GA BTJ55 UT WOS:000287096002206 ER PT S AU Cardenas-Juarez, M Ghogho, M Swami, A AF Cardenas-Juarez, Marco Ghogho, Mounir Swami, Ananthram GP IEEE TI Semi-blind Locally Optimum Detection for Spectrum Sensing in Cognitive Radio SO 2010 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 10-19, 2010 CL Dallas, TX SP IEEE Signal Proc Soc DE Spectrum Sensing; Cognitive Radio; Locally Optimum Detection; Signal Detection AB Spectrum sensing in cognitive radio becomes a challenging task when the signals received at the secondary users' transmitters exhibit low power. Locally optimum detectors (LOD) are therefore desirable thanks to their optimality in the low SNR regime. Here, we assume that the primary user transmits a training sequence, and propose a semi-blind LOD (SBLOD). In the case of BPSK signals, the test statistic of the proposed SBLOD is shown to be a weighted sum of the matched filter output, the energy and pseudo-energy. For higher size constellations, the SBLOD reduces to a linear combination of the matched filter and the energy detector. Although combining the matched filter and energy detector is a classical approach, our study provides a systematic and (locally) optimal way of combining these detectors. Simulations results show the merits of the proposed detector. C1 [Cardenas-Juarez, Marco; Ghogho, Mounir] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Cardenas-Juarez, M (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. NR 4 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 BN 978-1-4244-4296-6 J9 INT CONF ACOUST SPEE PY 2010 BP 2962 EP 2965 DI 10.1109/ICASSP.2010.5496136 PG 4 WC Acoustics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Acoustics; Computer Science; Engineering GA BTJ55 UT WOS:000287096002226 ER PT S AU Mitliagkas, I Sidiropoulos, ND Swami, A AF Mitliagkas, I. Sidiropoulos, N. D. Swami, A. GP IEEE TI DISTRIBUTED JOINT POWER AND ADMISSION CONTROL FOR AD-HOC AND COGNITIVE UNDERLAY NETWORKS SO 2010 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING SE International Conference on Acoustics Speech and Signal Processing ICASSP LA English DT Proceedings Paper CT 2010 IEEE International Conference on Acoustics, Speech, and Signal Processing CY MAR 10-19, 2010 CL Dallas, TX SP IEEE Signal Proc Soc AB Power control is important in interference-limited cellular, ad-hoc, and cognitive wireless networks, when the objective is to ensure a certain quality of service to each connection. Power control has been extensively studied in this context, including distributed algorithms that are particularly appealing in ad-hoc and cognitive settings. A long-standing issue is that the power control problem may be infeasible, thus requiring appropriate admission control. The power and admission control parts of the problem are tightly coupled, but the joint problem is NP-hard. In recent work, we developed a convex relaxation-based deflation approach to the joint problem, which was shown to outperform the prior art, and yield close to optimal solutions at moderate computational cost. In this paper, we derive a distributed version of our joint power and admission control algorithm. The algorithm alternates between distributed approximation and distributed deflation - reaching consensus on a user to drop, when needed. Both phases require only local communication and computation, yielding a relatively lightweight distributed algorithm which also attains close to optimal performance. C1 [Mitliagkas, I.; Sidiropoulos, N. D.] TU Crete, Dept ECE, Khania 73100, Greece. [Swami, A.] Army Res Lab, Adelphi, MD 20783 USA. RP Mitliagkas, I (reprint author), TU Crete, Dept ECE, Khania 73100, Greece. EM nikos@telecom.tuc.gr; a.swami@ieee.org NR 10 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1520-6149 BN 978-1-4244-4296-6 J9 INT CONF ACOUST SPEE PY 2010 BP 3014 EP 3017 DI 10.1109/ICASSP.2010.5496132 PG 4 WC Acoustics; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Acoustics; Computer Science; Engineering GA BTJ55 UT WOS:000287096002239 ER PT S AU Lu, Z Wang, C Wang, WY AF Lu, Zhuo Wang, Cliff Wang, Wenye GP IEEE TI On the Impact of Backoff Misbehaving Nodes in IEEE 802.11 Networks SO 2010 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS SE IEEE International Conference on Communications LA English DT Proceedings Paper CT 2010 IEEE International Conference on Communications CY MAY 23-27, 2010 CL Cape Town, SOUTH AFRICA SP IEEE ID PERFORMANCE ANALYSIS AB In this paper, we address the problem of quantifying the impact of backoff misbehaving nodes in IEEE 802.11 networks. We propose two performance metrics, throughput gain ratio and throughput degradation ratio to quantify the performance gain of misbehaving nodes over legitimate nodes and the performance loss of legitimate nodes due to backoff misbehavior, respectively. We use asymptotic analysis to derive both throughput gain ratio and throughput degradation ratio in an IEEE 802.11 network in the presence of multiple misbehaving nodes. We show that, in general, the throughput gain ratio increases linearly with the number of legitimate nodes, and the throughput degradation ratio increases linearly with the number of misbehaving nodes. Finally, we use ns-2 simulations to validate our analytical results. C1 [Lu, Zhuo; Wang, Wenye] NC State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. [Wang, Cliff] Army Res Off, Res Triangle Pk, NC 27709 USA. RP Lu, Z (reprint author), NC State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. EM zlu3@ncsu.edu; cliff.wang@us.army.mil; wwang@ncsu.edu FU Army Research Office (ARO) [53435-CS-SR] FX The work was supported by Army Research Office (ARO) under Grant Number 53435-CS-SR. NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-3607 BN 978-1-4244-6404-3 J9 IEEE ICC PY 2010 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BUU13 UT WOS:000290335602136 ER PT S AU Ren, W Zhao, Q Swami, A AF Ren, Wei Zhao, Qing Swami, Ananthram GP IEEE TI On the Connectivity and Multihop Delay of Ad Hoc Cognitive Radio Networks SO 2010 IEEE INTERNATIONAL CONFERENCE ON COMMUNICATIONS SE IEEE International Conference on Communications LA English DT Proceedings Paper CT 2010 IEEE International Conference on Communications CY MAY 23-27, 2010 CL Cape Town, SOUTH AFRICA SP IEEE DE Cognitive radio network; multihop delay; connectivity; intermittent connectivity; continuum percolation ID CAPACITY; TRADEOFFS AB We analyze the multihop delay of ad hoc cognitive radio networks, where the transmission delay of each hop consists of the propagation delay and the waiting time for the availability of the communication channel (i.e., the occurrence of a spectrum opportunity at that hop). Using theories and techniques from continuum percolation and ergodicity, we establish the scaling law of the minimum multihop delay with respect to the source-destination distance. We show the starkly different scaling behavior of the multihop delay in instantaneously connected networks as compared to networks that are only intermittently connected due to the scarcity of spectrum opportunities. C1 [Ren, Wei; Zhao, Qing] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Ren, W (reprint author), Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. FU National Science Foundation [CCF-0830685]; Army Research Laboratory [DAAD19-01-C-0062]; Cooperative Agreement [W911NF-09-2-0053] FX 0Research was sponsored, in part, by the National Science Foundation under Grant CCF-0830685 and by the Army Research Laboratory and was accomplished under Grant DAAD19-01-C-0062 and Cooperative Agreement Number W911NF-09-2-0053. NR 21 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1550-3607 BN 978-1-4244-6404-3 J9 IEEE ICC PY 2010 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BUU13 UT WOS:000290335602125 ER PT S AU Patel, VM Nasrabadi, NM Chellappa, R AF Patel, Vishal M. Nasrabadi, Nasser M. Chellappa, Rama GP IEEE TI AUTOMATIC TARGET RECOGNITION BASED ON SIMULTANEOUS SPARSE REPRESENTATION SO 2010 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING SE IEEE International Conference on Image Processing ICIP LA English DT Proceedings Paper CT IEEE International Conference on Image Processing CY SEP 26-29, 2010 CL Hong Kong, PEOPLES R CHINA SP IEEE, IEEE Signal Proc Soc DE Automatic Target Recognition; Forward-Looking Infrared (FLIR) Imagery; Simultaneous orthogonal matching pursuit (SOMP); Sparse representation ID CLASSIFICATION AB In this paper, an automatic target recognition algorithm is presented based on a framework for learning dictionaries for simultaneous sparse signal representation and feature extraction. The dictionary learning algorithm is based on class supervised simultaneous orthogonal matching pursuit while a matching pursuit-based similarity measure is used for classification. We show how the proposed framework can be helpful for efficient utilization of data, with the possibility of developing real-time, robust target classification. We verify the efficacy of the proposed algorithm using confusion matrices on the well known Comanche forward-looking infrared data set consisting of ten different military targets at different orientations. C1 [Patel, Vishal M.; Chellappa, Rama] Univ Maryland, Dept Elect & Comp Engn, Ctr Automat Res, UMIACS, College Pk, MD 20742 USA. [Nasrabadi, Nasser M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Patel, VM (reprint author), Univ Maryland, Dept Elect & Comp Engn, Ctr Automat Res, UMIACS, College Pk, MD 20742 USA. EM pvishalm@umiacs.umd.edu; nnasraba@arl.army.mil; rama@umiacs.umd.edu FU ARO STIR [W911NF0910408] FX This work was partially supported by an ARO STIR Grant W911NF0910408. NR 15 TC 4 Z9 4 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-4880 BN 978-1-4244-7994-8 J9 IEEE IMAGE PROC PY 2010 BP 1377 EP 1380 DI 10.1109/ICIP.2010.5652306 PG 4 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology SC Engineering; Imaging Science & Photographic Technology GA BTP82 UT WOS:000287728001119 ER PT S AU Peng, HH Rao, R AF Peng, Honghong Rao, Raghuveer GP IEEE TI BILATERAL KERNEL PARAMETER OPTIMIZATION BY RISK MINIMIZATION SO 2010 IEEE INTERNATIONAL CONFERENCE ON IMAGE PROCESSING SE IEEE International Conference on Image Processing ICIP LA English DT Proceedings Paper CT IEEE International Conference on Image Processing CY SEP 26-29, 2010 CL Hong Kong, PEOPLES R CHINA SP IEEE, IEEE Signal Proc Soc DE Bilateral filtering; Stein's unbiased risk estimator; parameter optimization AB A statistical approach is presented for determining the optimal parameters of a bilateral filter for suppressing noise in an image. A closed-form solution to obtaining Stein's unbiased estimate of the bilateral filter-based image estimation risk is derived. The values of the parameters are then determined by minimization of the estimated risk, which is equivalent to maximization of the estimated signal to noise ratio. Experimental results show that the method provides estimates of noise intensity that are close to the actual, and the performance of the bilateral filter, in terms of providing good tradeoff between noise suppression and edge preservation, is improved significantly by using the optimal parameters estimate. C1 [Peng, Honghong] Aptina Imaging, Mail Stop 65-400,3080 N First St, San Jose, CA 95134 USA. [Rao, Raghuveer] Army Res Lab, RDRL SES E, Adelphi, MD 20783 USA. RP Peng, HH (reprint author), Aptina Imaging, Mail Stop 65-400,3080 N First St, San Jose, CA 95134 USA. NR 9 TC 21 Z9 21 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1522-4880 BN 978-1-4244-7994-8 J9 IEEE IMAGE PROC PY 2010 BP 3293 EP 3296 DI 10.1109/ICIP.2010.5651045 PG 4 WC Engineering, Electrical & Electronic; Imaging Science & Photographic Technology SC Engineering; Imaging Science & Photographic Technology GA BTP82 UT WOS:000287728003093 ER PT S AU Okusaga, O Adles, E Zhou, WM Menyuk, C Carter, G Levy, E Horowitz, M AF Okusaga, Olukayode Adles, Eric Zhou, Weimin Menyuk, Curtis Carter, Gary Levy, Etgar Horowitz, Moshe GP IEEE TI Spurious-Mode Suppression in Optoelectronic Oscillators SO 2010 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (FCS) SE IEEE International Frequency Control Symposium LA English DT Proceedings Paper CT 2010 IEEE International Frequency Control Symposium CY JUN 01-04, 2010 CL Newport Beach, CA SP IEEE AB Optoelectronic oscillators (OEOs) are promising low phase noise radio frequency sources. However, the long fiber loops required for a high Oscillator Q also lead to spurious modes (spurs) spaced too narrowly to be filtered by standard electronic devices. As a solution to this problem, the dual injection-locked OEo (DIL-OEO) has been proposed and studied. Previously, we presented experimental data demonstrating spur suppression in the DIL-OEO. We also developed theoretical models enabling us to optimize the DIL-OEO. In this work, we present data demonstrating 60 dB suppression of the nearest-neighbour spur in a high-Q OEO without increasing the phase noise within 1 kHz of the 10 GHz oscillating mode. C1 [Okusaga, Olukayode; Adles, Eric; Zhou, Weimin] USA, Res Lab, Adelphi, MD 20783 USA. [Carter, Gary; Levy, Etgar; Horowitz, Moshe] Dept Comp Sci & Elect Engn, Baltimore, MD USA. [Levy, Etgar; Horowitz, Moshe] Technion Israel Inst Technol, Haifa, Israel. RP Okusaga, O (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM olukayode.okusaga@us.army.mil FU DARPA FX The authors would like to thank DARPA for funding this research. NR 6 TC 4 Z9 4 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1075-6787 BN 978-1-4244-6401-2 J9 P IEEE INT FREQ CONT PY 2010 BP 539 EP 543 DI 10.1109/FREQ.2010.5556272 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTM93 UT WOS:000287378700115 ER PT S AU Adles, EJ Docherty, A Menyuk, C Carter, G Okusaga, O Zhou, WM Levy, E David, A Horowitz, M AF Adles, Eric J. Docherty, Andrew Menyuk, Curtis Carter, Gary Okusaga, Olukayode Zhou, Weimin Levy, Etgar David, Asaf Horowitz, Moshe GP IEEE TI Loop-length Dependent Sources of Phase Noise in Optoelectronic Oscillators SO 2010 IEEE INTERNATIONAL FREQUENCY CONTROL SYMPOSIUM (FCS) SE IEEE International Frequency Control Symposium LA English DT Proceedings Paper CT 2010 IEEE International Frequency Control Symposium CY JUN 01-04, 2010 CL Newport Beach, CA SP IEEE AB Optoelectronic oscillators are a promising source of spectrally pure, easily tunable microwave signals. These oscillators use a low-loss fiber optic delay line as a very high Q resonant cavity. However, length-dependent sources of phase noise prevent the full Q of the resonant cavity from being realized. Here we show evidence that this length-dependent phase noise is in part dependent upon the optical power and laser noise. This dependence is consistent with the conversion of laser noise to phase noise via the Kerr effect. C1 [Adles, Eric J.; Docherty, Andrew; Menyuk, Curtis; Carter, Gary] Univ Maryland Baltimore Cty, Dept Elect & Comp Engn, Baltimore, MD 21250 USA. [Okusaga, Olukayode; Zhou, Weimin] U S Army Res Lab, Adelphi, MD 20783 USA. [Levy, Etgar; David, Asaf; Horowitz, Moshe] Technion Israel Inst Technol, Haifa, Israel. RP Adles, EJ (reprint author), Univ Maryland Baltimore Cty, Dept Elect & Comp Engn, Baltimore, MD 21250 USA. EM ejadles@gmail.com FU DARPA FX This work was supported by DARPA under the SILO program. NR 7 TC 5 Z9 5 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1075-6787 BN 978-1-4244-6401-2 J9 P IEEE INT FREQ CONT PY 2010 BP 550 EP 553 DI 10.1109/FREQ.2010.5556267 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTM93 UT WOS:000287378700118 ER PT S AU Chen, Y Nasrabadi, NM Tran, TD AF Chen, Yi Nasrabadi, Nasser M. Tran, Trac D. GP IEEE TI SPARSITY-BASED CLASSIFICATION OF HYPERSPECTRAL IMAGERY SO 2010 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT 30th IEEE International Geoscience and Remote Sensing Symposium (IGARSS) on Remote Sensing - Global Vision for Local Action CY JUN 25-30, 2010 CL Honolulu, HI SP IEEE ID SUBSPACE DETECTORS; PURSUIT AB In this paper, a new sparsity-based classification algorithm for hyperspectral imagery is proposed. This algorithm is based on the concept that a pixel in hyperspectral imagery lies in a low-dimensional subspace and thus can be represented by a sparse linear combination of the training samples. The sparse representation (a sparse vector representing the selected training samples) of a test sample can be recovered by solving a constrained optimization problem. Once the sparse vector is obtained, the class of the test sample can be directly determined by the behavior of the vector on reconstruction. In addition to the constraints on sparsity and reconstruction accuracy, we also exploit the fact that hyperspectral images are usually smooth within a neighborhood. In our proposed algorithm, a smoothness constraint is imposed by forcing the Laplacian of the reconstructed image to be minimum in the optimization process. The proposed sparsity-based algorithm is applied to several hyperspectral imagery to classify the pixels into target and background classes. Simulation results show that our algorithm outperforms the classical hyperspectral target detection algorithms, such as the popular spectral matched filters, matched subspace detectors, and adaptive subspace detectors. C1 [Chen, Yi; Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, 3400 N Charles St, Baltimore, MD 21218 USA. [Nasrabadi, Nasser M.] US Air Force, Res Lab, Adelphi, MD 20783 USA. RP Chen, Y (reprint author), Johns Hopkins Univ, Dept Elect & Comp Engn, 3400 N Charles St, Baltimore, MD 21218 USA. NR 9 TC 4 Z9 6 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4244-9566-5 J9 INT GEOSCI REMOTE SE PY 2010 BP 2796 EP 2799 DI 10.1109/IGARSS.2010.5649357 PG 4 WC Geosciences, Multidisciplinary; Remote Sensing SC Geology; Remote Sensing GA BTS07 UT WOS:000287933802242 ER PT J AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung GP IEEE TI A FULL DIAGONAL BANDWIDTH GAUSSIAN KERNEL SVM BASED ENSEMBLE LEARNING FOR HYPERSPECTRAL CHEMICAL PLUME DETECTION SO 2010 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium CY JUN 25-30, 2010 CL Honolulu, HI SP IEEE DE SVM; Ensemble Learning; Sparse Kernel Learning; Kernel Parameter Optimization; Chemical Plume Detection AB Recently, a sparse kernel-based SVM ensemble learning technique has been introduced by the authors for hyperspectral plume detection/classification. This technique first randomly selects spectral feature subspaces from the input data. Each individual SVM classifier then independently conducts its own learning within its corresponding spectral feature space using a Gaussian kernel with a single bandwidth parameter. Each classifier constitutes a weak classifier. The sub-classifiers are sparsely weighted and aggregated to make an ensemble decision. In this paper, in order to further improve the generalization performance of the ensemble classifier, Gaussian kernel with full diagonal bandwidth parameter matrix is used for each sub-classifier where the parameters are optimally learned by minimizing a bound of the generalization error estimate using a gradient descent algorithm. A performance comparison between the aggregating techniques - sparse kernel-based technique and majority voting with single bandwidth and full diagonal optimized bandwidth parameters as applied to hyperspectral chemical plume detection is presented in the paper. C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, ATTN RDRL SES E, Adelphi, MD 20783 USA. RP Gurram, P (reprint author), USA, Res Lab, ATTN RDRL SES E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 11 TC 1 Z9 1 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-9566-5 J9 INT GEOSCI REMOTE SE PY 2010 BP 2804 EP 2807 DI 10.1109/IGARSS.2010.5649859 PG 4 WC Geosciences, Multidisciplinary; Remote Sensing SC Geology; Remote Sensing GA BTS07 UT WOS:000287933802244 ER PT J AU Kwon, H Gurram, P AF Kwon, Heesung Gurram, Prudhvi GP IEEE TI OPTIMAL KERNEL BANDWIDTH ESTIMATION FOR HYPERSPECTRAL KERNEL-BASED ANOMALY DETECTION SO 2010 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT IEEE International Geoscience and Remote Sensing Symposium CY JUN 25-30, 2010 CL Honolulu, HI SP IEEE DE Anomaly Detection; Hyperspectral Images; Kernel RX algorithm; Kernel Parameter Optimization AB A kernel-based anomaly detection technique called Kernel RX algorithm has been developed earlier by one of the authors, to be used as a prescreening tool that non-linearly detects anomalous pixel spectra in hyperspectral images. Targets of interest are then identified among the prescreened anomalous spectra based on reference spectral information using supervised classification/detection techniques. Kernel RX algorithm uses kernels like the Gaussian radial basis function (RBF) kernel to transform the given data into higher-dimensional (possibly infinite) feature space before detecting the anomalies. The efficiency of the algorithm depends on this transformation which in turn depends on the respective kernel parameters. The Gaussian RBF kernel has a parameter called bandwidth parameter. In this paper, a new method to determine the optimal full diagonal bandwidth parameters of the Gaussian RBF kernel is presented. First, cross-validation technique is used to estimate an optimal single bandwidth parameter. Then, the full diagonal parameters are estimated from this single parameter using the variances of the spectral bands of the hyperspectral image. It will be shown that the optimal full diagonal bandwidth parameters provide a better probability of detection at a given false alarm rate compared to the optimal single bandwidth parameter and other suboptimal bandwidth parameters when tested on hyperspectral imagery for military target detection. C1 [Kwon, Heesung; Gurram, Prudhvi] USA, Res Lab, ATTN RDRL SES E, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), USA, Res Lab, ATTN RDRL SES E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 4 TC 5 Z9 5 U1 0 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-9566-5 J9 INT GEOSCI REMOTE SE PY 2010 BP 2812 EP 2815 DI 10.1109/IGARSS.2010.5649775 PG 4 WC Geosciences, Multidisciplinary; Remote Sensing SC Geology; Remote Sensing GA BTS07 UT WOS:000287933802246 ER PT S AU Hessner, K Hanson, JL AF Hessner, Katrin Hanson, Jeffrey L. GP IEEE TI EXTRACTION OF COASTAL WAVEFIELD PROPERTIES FROM X-BAND RADAR SO 2010 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT 30th IEEE International Geoscience and Remote Sensing Symposium (IGARSS) on Remote Sensing - Global Vision for Local Action CY JUN 25-30, 2010 CL Honolulu, HI SP IEEE DE Marine radar; coastal wave monitoring; wave climatology; wavefield analysis; wave partitioning ID OCEAN AB The dynamic wave field in a high-energy coastal environment is investigated using frequency direction wave spectra obtained by nautical X-band radar imagery. Nautical radars are generally used for navigation and ship traffic control. Under various conditons (wind speed > 3m/s, significant wave height > 0.5m(1)), signatures of the sea surface (sea clutter) become visible in the near range (less than 3 nautical miles) of naurtical radar images. Swell and wind sea waves become visible in nautical radar images as they modulate the sea clutter signal. Since standard X-band nautical radar systems scan the sea surface with high temporal and spatial resolution, they are able to monitor the sea surface in both time and space. The combination of the temporal and spatial wave information allows the determination of unambiguous directional wave spectra. Here, wave data collected from February-October 2005 at the US Army Corps of Engineering Field Research Facility (USACE-FRF) in Duck, North Carolina is presented. For the radar wave measurements the Wave and surface current Monitoring System WaMoS II was connected to a Furuno FR-7112 X-Band radar with a 6 feet open antenna and an update rate of 2.5s (24 rpm). The radar covers a range from 240m - 2160m from the antenna with a spatial resolution of 7.5m. The wave analysis was carried out over an area of 3.7 km(2) located in relative homogenous bottom topography, off the near shore breaker bar system, in a water depth of 8m-10m. The WaMoS II wave measurements were compared to those obtained from a pressure gauge array located in the same area. Earlier WaMoS II validations provide a general indicator of the quality of the measurement performance as they were carried out for standard integral wave properties overall existing wave systems such as mean or peak wave parameters. Here the XWaves ocean wave field analysis toolbox is used to compare data sets by means of a wave spectral partitioning analysis. This approach provides a more detailed validation especially for bi- and multi modal sea states, allows for a comparison of the heights, periods and directions of individual wind sea and swell components, and tracking the evolution of specific wave systems. Such analysis methods have been successfully applied in a variety of wave model validations. The data comparison was carried out for different sea state and wind conditions. Preliminary results of the data comparison show that the WaMoS II system captures the temporal evolution of the individual wind sea and swell wave components entering the surf zone. A statistical error analysis of the isolated wind sea and swell wave systems provides a quantitative assessment of WaMoS II performance in a coastal setting. C1 [Hessner, Katrin] OceanWaveS GmbH, Munstermannskamp 1, D-21335 Luneburg, Germany. [Hanson, Jeffrey L.] US Army Corps Engn, Kitty Hawk, NC USA. RP Hessner, K (reprint author), OceanWaveS GmbH, Munstermannskamp 1, D-21335 Luneburg, Germany. EM hessner@oceanwaves.de; jeffrey.l.hanson@usace.army.mil NR 9 TC 3 Z9 3 U1 1 U2 13 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4244-9566-5 J9 INT GEOSCI REMOTE SE PY 2010 BP 4326 EP 4329 DI 10.1109/IGARSS.2010.5650134 PG 4 WC Geosciences, Multidisciplinary; Remote Sensing SC Geology; Remote Sensing GA BTS07 UT WOS:000287933804122 ER PT S AU Lyzenga, D Nwogu, O Trizna, D Hathaway, K AF Lyzenga, David Nwogu, Okey Trizna, Dennis Hathaway, Kent GP IEEE TI OCEAN WAVE FIELD MEASUREMENTS USING X-BAND DOPPLER RADARS AT LOW GRAZING ANGLES SO 2010 IEEE INTERNATIONAL GEOSCIENCE AND REMOTE SENSING SYMPOSIUM SE IEEE International Symposium on Geoscience and Remote Sensing IGARSS LA English DT Proceedings Paper CT 30th IEEE International Geoscience and Remote Sensing Symposium (IGARSS) on Remote Sensing - Global Vision for Local Action CY JUN 25-30, 2010 CL Honolulu, HI SP IEEE DE Marine Technology; Doppler Radar; Sea Surface Electromagnetic Scattering AB Ocean wave field observations using two types of Doppler radar systems are compared with time series measurements of the surface elevation at the USACE Field Research Facility (FRF) in Duck, NC. C1 [Lyzenga, David; Nwogu, Okey] Univ Michigan, Naval Architecture & Marine Engn Dept, Ann Arbor, MI 48109 USA. [Trizna, Dennis] Imaging Sci Res Inc, Richmond, VA 23220 USA. [Hathaway, Kent] US Army Corp Engn, Coastal & Hydraul Lab, Washington, DC 20032 USA. RP Lyzenga, D (reprint author), Univ Michigan, Naval Architecture & Marine Engn Dept, Ann Arbor, MI 48109 USA. FU Naval Research through a MURI project [N00014-05-1-0537]; DURIP [N00014-06-1-0526]; Office of the Vice President for Research at the University of Michigan FX This work was largely funded by the Office of Naval Research through a MURI project (N00014-05-1-0537) at the University of Michigan. The radars were constructed under DURIP funding (award no. N00014-06-1-0526). Additional funding was provided by the Office of the Vice President for Research at the University of Michigan. NR 3 TC 1 Z9 1 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-6996 BN 978-1-4244-9566-5 J9 INT GEOSCI REMOTE SE PY 2010 BP 4725 EP 4728 DI 10.1109/IGARSS.2010.5650065 PG 4 WC Geosciences, Multidisciplinary; Remote Sensing SC Geology; Remote Sensing GA BTS07 UT WOS:000287933804226 ER PT S AU Chi, YM Carhart, G Vorontsov, MA Cauwenberghs, G AF Chi, Yu M. Carhart, Gary Vorontsov, Mikhail A. Cauwenberghs, Gert GP IEEE TI Intensity Histogram CMOS Image Sensor for Adaptive Optics SO 2010 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS SE IEEE International Symposium on Circuits and Systems LA English DT Proceedings Paper CT International Symposium on Circuits and Systems Nano-Bio Circuit Fabrics and Systems (ISCAS 2010) CY MAY 30-JUN 02, 2010 CL Paris, FRANCE SP IEEE, CAS, ISEP AB We present a high-speed CMOS active pixel sensor (APS) image sensor with focal plane histogram computation. The 128x128 4-transistor active pixel sensor array produces cumulative intensity histograms, at the focal-plane, with speeds in excess of 10,000 frames per second for low-latency, real-time control applications without the need for pixel digitization of external processing. In addition, an on-chip 10-bit column parallel analog-to-digital converter with a read noise of 0.6LSB and negligible fixed pattern noise facilitates conventional imaging operations and data acquisition. Each pixel occupies 19.5 mu m x19.5 mu m with a fill factor of 43%. Power consumption is 1.5mW during imaging mode and 4.6mW in high-speed histogram mode. Applications include real-time adaptive optics control for laser communications. C1 [Chi, Yu M.] Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA. [Cauwenberghs, Gert] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA. [Carhart, Gary; Vorontsov, Mikhail A.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Chi, YM (reprint author), Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA. FU Army Research Lab, Adelphi, Maryland, DARPA APPLE program FX This work was supported by a collaborative agreement with the Army Research Lab, Adelphi, Maryland as part of the DARPA APPLE program. NR 7 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0271-4302 BN 978-1-4244-5309-2 J9 IEEE INT SYMP CIRC S PY 2010 BP 633 EP 636 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BTL36 UT WOS:000287216000158 ER PT S AU Corron, NJ Stahl, MT Blakely, JN AF Corron, Ned J. Stahl, Mark T. Blakely, Jonathan N. GP IEEE TI Exactly Solvable Chaotic Circuit SO 2010 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS SE IEEE International Symposium on Circuits and Systems LA English DT Proceedings Paper CT International Symposium on Circuits and Systems Nano-Bio Circuit Fabrics and Systems (ISCAS 2010) CY MAY 30-JUN 02, 2010 CL Paris, FRANCE SP IEEE, CAS, ISEP ID SYMBOLIC DYNAMICS; SYSTEMS AB We report the construction and operation of a novel chaotic electronic oscillator for which a detailed model admits an exact analytic solution. The circuit is modeled by a hybrid dynamical system including both a differential equation and discrete switching condition. The analytic solution is written as the linear convolution of a symbol sequence and a fixed basis pulse, similar to that of conventional communications waveforms. Waveform returns sampled at the switching times are shown to be conjugate to a chaotic shift map, effectively proving the existence of chaos in the circuit. We show the analytic solution can be used to accurately reconstruct a measured chaotic waveform, thereby confirming the efficacy of the exactly solvable circuit model. C1 [Corron, Ned J.; Stahl, Mark T.; Blakely, Jonathan N.] USA, Res Dev & Engn Command, RDMR WSS, Redstone Arsenal, AL 35898 USA. RP Corron, NJ (reprint author), USA, Res Dev & Engn Command, RDMR WSS, Redstone Arsenal, AL 35898 USA. EM ned.corron@us.army.mil OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0271-4302 BN 978-1-4244-5309-2 J9 IEEE INT SYMP CIRC S PY 2010 BP 1356 EP 1359 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BTL36 UT WOS:000287216001146 ER PT S AU Waller, ML Shumpert, TH Scharstein, RW AF Waller, Marsellas L. Shumpert, Thomas H. Scharstein, Robert W. GP IEEE TI Aperture Coupling Near-Field Cavity Effects for Electromagnetic Testing with Measurements on a Slotted Circular Cylinder\ SO 2010 IEEE INTERNATIONAL SYMPOSIUM ON ELECTROMAGNETIC COMPATIBILITY (EMC 2010) SE IEEE International Symposium on Electromagnetic Compatibility LA English DT Proceedings Paper CT IEEE International Symposium on Electromagnetic Compatibility CY JUL 25-30, 2010 CL Ft Lauderdale, FL SP EMC Soc, IEEE AB Electric field measurements for an electromagnetic wave excited from a log-periodic dipole array at two separation distances on a finite slotted circular cylinder are compared to an analytical model of a plane wave on an infinite slotted circular cylinder. The four foot diameter cylinder cross section is used to represent the cross section (1/2 scale) of an Army Blackhawk helicopter. The frequency range of interest is in the Very High Frequency (VHF) band where the first resonances of the cavity occur. Transverse Magnetic (TM) and Transverse Electric (TE) polarizations are considered. C1 [Waller, Marsellas L.; Shumpert, Thomas H.] US Army, Redstone Test Ctr P, Redstone Arsenal, AL 35898 USA. [Scharstein, Robert W.] Univ Alabama, Tuscaloosa, AL 35487 USA. RP Waller, ML (reprint author), US Army, Redstone Test Ctr P, Redstone Arsenal, AL 35898 USA. EM marsellas.waller@us.army.mil; thomas.shumpert@us.army.mil; rscharst@bama.ua.edu NR 3 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2158-110X BN 978-1-4244-6307-7 J9 IEEE INT SYMP ELEC PY 2010 BP 62 EP 66 DI 10.1109/ISEMC.2010.5711248 PG 5 WC Engineering, Electrical & Electronic SC Engineering GA BWU78 UT WOS:000294962100013 ER PT S AU Qiu, JX AF Qiu, Joe X. GP IEEE TI Time-Domain Calibration Technique for Ultra-Wide Instantaneous-Bandwidth Vector Waveform Generation Using Parallel I/Q Channels SO 2010 IEEE MTT-S INTERNATIONAL MICROWAVE SYMPOSIUM DIGEST (MTT) SE IEEE MTT-S International Microwave Symposium LA English DT Proceedings Paper CT IEEE MTT-S International Microwave Symposium Digest CY MAY 23-28, 2010 CL Anaheim, CA SP IEEE DE Digital-to-analog conversion; I/Q modulation; vector signal; channelization; NMSE; UWB; QAM ID SYSTEM; RADIO AB An architecture for generating ultra-wide instantaneous-bandwidth vector waveforms by combining the spectra of multiple I/Q sub-channels is described. Each sub-channel consists of an I/Q modulator driven by a pair of digital-to-analog converters. A time-domain calibration technique is described that uses the measured channel response to equalize the sub-channels. The overall response of the combined system is realized by properly controlling the phases of the corrected I/Q sub-channels. Examples of wideband vector waveforms generated using the combined system will be given. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Qiu, JX (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 8 TC 2 Z9 2 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-645X BN 978-1-4244-6057-1 J9 IEEE MTT S INT MICR PY 2010 BP 1624 EP 1627 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BTV71 UT WOS:000288196501177 ER PT S AU Tahmoush, D Silvious, J AF Tahmoush, Dave Silvious, Jerry GP IEEE TI Simplified Model of Dismount MicroDoppler and RCS SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE ID FEATURE-EXTRACTION; HUMAN GAIT; RADAR AB Our goal is to be able to detect and classify dismounts, but we were lacking a quick way to estimate dismount parameters, especially with respect to angle of motion and depression angle of the radar. Micro-Doppler models have been developed which attempt to predict the human micro-Doppler response, and here we present a simplified model to quickly estimate dismount RCS and some micro-Doppler characteristics across a range of angles of motion. This model was extracted from measured radar data. We focus on modeling and measuring the characteristics of human walking parameters to determine response of dismounts to radar signals. We determine a simple closed form for RCS as a function of angle for walking dismounts as well as several rules of thumb, and we also determine a closed form for front-view micro-Doppler. C1 [Tahmoush, Dave; Silvious, Jerry] USA, Res Lab, Adelphi, MD 20783 USA. RP Tahmoush, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 20 TC 9 Z9 9 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 31 EP 34 DI 10.1109/RADAR.2010.5494657 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500007 ER PT S AU Martone, A Ranney, K Innocenti, R AF Martone, Anthony Ranney, Kenneth Innocenti, Roberto GP IEEE TI Automatic Through the Wall Detection of Moving Targets using Low-Frequency Ultra-Wideband Radar SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE AB This paper presents a time-domain, Moving Target Indication (MTI) processing formulation for detecting slow-moving personnel behind walls. The proposed time-domain MTI processing formulation consists of change detection and automatic target recognition algorithms. We demonstrate the effectiveness of the MTI processing formulation using data collected by an impulse-based, low-frequency, ultra-wideband radar. In this paper, we describe our radar system and algorithms used for the automatic detection of moving personnel. We also analyze the false alarm and detection rate of four operational scenarios of personnel walking inside wood and cinderblock buildings. C1 [Martone, Anthony; Ranney, Kenneth; Innocenti, Roberto] USA, Res Lab, Adelphi, MD 20783 USA. RP Martone, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 8 TC 29 Z9 29 U1 3 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 39 EP 43 DI 10.1109/RADAR.2010.5494655 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500009 ER PT S AU Goldman, GH AF Goldman, Geoffrey H. GP IEEE TI Computationally Efficient Resampling of Nonuniform Oversampled SAR Data SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE ID SYNTHETIC-APERTURE RADAR AB A computationally efficient technique is developed to resample SAR data oversampled in the slow-time domain for a platform accelerating along the track. The algorithm segments the data between uniformly spaced points on the synthetic aperture, then performs a weighted average on the demodulated SAR data in each segment to adjust the effective sample position on the aperture. The weighting is derived using a first-order Taylor series approximation and used parameters from the velocity and acceleration of the platform and the radar waveform. C1 USA, Res Lab, Signal & Image Proc Div, Adelphi, MD 20783 USA. RP Goldman, GH (reprint author), USA, Res Lab, Signal & Image Proc Div, Adelphi, MD 20783 USA. EM geoffrey.goldman@us.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 70 EP 74 DI 10.1109/RADAR.2010.5494649 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500015 ER PT S AU Crowne, F Fazi, C AF Crowne, Frank Fazi, Christian GP IEEE TI Second-Harmonic Generation by Electromagnetic Waves at the Surface of a Semi-Infinite Metal SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE DE second harmonic; scattering; metal physics; radar nonlinear response; radar cross section AB Reference [1], which appears in the Proceedings of the RADAR'09 Conference at Bordeaux in October 2009, describes nonlinear currents generated by an electromagnetic wave incident on a metal surface. This paper supplements the results of [1] with a full calculation of the RCS per unit area for second harmonic generation. These results verify that the level of such emission from a metal surface is anomalously low. C1 [Crowne, Frank; Fazi, Christian] USA, Sensors & Elect Directorate, Res Lab, Adelphi, MD USA. RP Crowne, F (reprint author), USA, Sensors & Elect Directorate, Res Lab, Adelphi, MD USA. NR 12 TC 9 Z9 9 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 385 EP 390 DI 10.1109/RADAR.2010.5494592 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500074 ER PT S AU Lam, N Innocenti, R AF Lam Nguyen Innocenti, Roberto GP IEEE TI Suppression of Sidelobes and Noise in Airborne SAR Imagery Using the Recursive Sidelobe Minimization Technique SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE AB The Army Research Laboratory (ARL) has recently developed the Recursive Side-lobe Minimization (RSM) technique (patent pending). The technique is integrated with a standard back-projection algorithm to form synthetic aperture radar (SAR) images with significant reduction in side-lobes and noise. We have achieved significant improvements in noise reduction by applying the RSM technique to our Ultrawideband (UWB) Synchronous Impulse Reconstruction (SIRE) forward-looking radar. This paper presents the application of the RSM technique using data from a side-looking airborne SAR system from SRI International. We describe the RSM technique, the SAR data processing, compare the baseline and RSM SAR images, and quantify the image quality in term of signal-to-noise ratio (SNR) and the statistical distribution of the image pixels to show that significant improvement achieved using the RSM technique. C1 [Lam Nguyen; Innocenti, Roberto] USAF, Res Lab, Adelphi, MD 20783 USA. RP Lam, N (reprint author), USAF, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM lnguyen@arl.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 522 EP 525 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500100 ER PT S AU McMillan, RW Kohlberg, I AF McMillan, R. W. Kohlberg, Ira GP IEEE TI A Probabilistic Model of the Radar Signal-to-Clutter and Noise Ratio for Weibull-Distributed Clutter SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE AB We consider four effects relevant to the determination of the ratio of radar signal to clutter and noise. These effects are atmospheric turbulence, target fluctuations based on the Swerling models, zero-mean Gaussian background and receiver noise, and Weibull-distributed clutter. Radar return signal levels are affected by target fluctuations and atmospheric turbulence, characterized by target fluctuations according to the Swerling models and a lognormal distribution, respectively. Since these distributions are not independent and identically distributed (IID), they cannot be simply added, and must be treated by combining them in a manner similar to convolution. Also, clutter and noise are not IID, and must be combined in a similar way. The ratio of these two combinations comprises a probabilistic model of the ratio of radar signal to clutter and noise. This ratio is the probability that a given signal level will be achieved in the presence of atmospheric and target scintillations divided by the probability that a given clutter and noise level will be observed. To determine the ratio of the actual signal to clutter and noise, we must multiply these probabilities by the mean powers resulting from these phenomena, as will be shown later. We treat several cases of interest by varying the average radar cross section, the log intensity standard deviation of turbulence, the radar threshold-to-noise and signal-to-noise ratios, and the distribution of Weibull clutter mentioned above. C1 [McMillan, R. W.] US Army, Space & Missile Def Command, POB 1500, Huntsville, AL 35807 USA. [Kohlberg, Ira] Kohlberg Assoc, Reston, VA 20190 USA. RP McMillan, RW (reprint author), US Army, Space & Missile Def Command, POB 1500, Huntsville, AL 35807 USA. EM bob.mcmillan@us.army.mil NR 10 TC 5 Z9 5 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 882 EP 886 DI 10.1109/RADAR.2010.5494495 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500167 ER PT S AU Yang, Y Blum, RS Sadler, BM AF Yang, Yang Blum, Rick S. Sadler, Brian M. GP IEEE TI Distributed Energy-Efficient Scheduling for Radar Signal Detection in Sensor Networks SO 2010 IEEE RADAR CONFERENCE SE IEEE National Radar Conference Proceedings LA English DT Proceedings Paper CT 2010 IEEE Radar Conference CY MAY 10-14, 2010 CL Washington, DC SP IEEE ID WIRELESS NETWORKS AB In this paper, we consider the problem of Neyman-Pearson detection of fluctuating narrowband radar signals using wireless sensor networks (WSNs), and we are interested in finding some approach which can optimize the signal detection performance jointly with the energy expenditure. Towards this goal, we propose a distributed and energy-efficient scheduling scheme to coordinate the communications between each sensor node and the fusion center. This scheduling scheme allows each sensor to make its own decision about when to send data to the fusion center, according to its own information and without consulting any other sensors. This distributed scheduling approach greatly reduces the dependence on the fusion center, and also attains an appealing balance between the detection performance and the energy efficiency. C1 [Yang, Yang; Blum, Rick S.] Lehigh Univ, ECE Dept, 19 Mem Dr W, Bethlehem, PA 18015 USA. [Sadler, Brian M.] US Army, Res Lab, Adelphi, MD 20783 USA. RP Yang, Y (reprint author), Lehigh Univ, ECE Dept, 19 Mem Dr W, Bethlehem, PA 18015 USA. EM yay204@lehigh.edu; rblum@ece.lehigh.edu; bsadler@arl.army.mil FU Air Force Research Laboratory [FA9550-09-1-0576]; National Science Foundation [CCF-0829958]; U.S. Army Research Office [W911NF-08-1-0449] FX This material is based on research supported by the Air Force Research Laboratory under agreement FA9550-09-1-0576, by the National Science Foundation under Grant CCF-0829958, and by the U.S. Army Research Office under Grant W911NF-08-1-0449. NR 11 TC 2 Z9 2 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1097-5659 BN 978-1-4244-5812-7 J9 IEEE NATL RADAR CONF PY 2010 BP 1094 EP 1099 DI 10.1109/RADAR.2010.5494458 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied; Telecommunications SC Engineering; Physics; Telecommunications GA BTO60 UT WOS:000287532500206 ER PT S AU Fischer, GA Edelstein, AS AF Fischer, G. A. Edelstein, A. S. GP IEEE TI Magnetic Modeling of a MEMS Flux Concentrator SO 2010 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 2010 IEEE Sensors Conference CY NOV 01-04, 2010 CL Kona, HI SP IEEE ID FIELD AMPLIFICATION; SENSORS; NOISE AB Magnetic flux concentrators are soft magnetic materials typically used to focus magnetic field lines in an effort to increase the sensitivity of a magnetic sensor. The use of magnetoresistive sensors, especially given the recent development of magnetic tunnel junctions (MTJ) with MgO barriers exhibiting magnetoresistance (MR) values as large as 400%, has created interest in flux concentrators as an avenue to not only increase sensitivity but to also mitigate the 1/f noise that is prevalent in these devices at low frequencies. Here we describe the magnetic modeling that has facilitated the development of the micromechanical system (MEMS) flux concentrator, a device that uses magnetic flux concentrators deposited on MEMS structures that modulate low frequency signals at the position of the sensor, essentially shifting the signal of interest to a frequency range in which 1/f noise is much lower. We present magnetic modeling results of various designs, including our current design, focusing on key design elements. C1 [Fischer, G. A.; Edelstein, A. S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Fischer, GA (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM greg.fischer@us.army.mil NR 12 TC 1 Z9 1 U1 3 U2 10 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4244-8168-2 J9 IEEE SENSOR PY 2010 BP 182 EP 187 DI 10.1109/ICSENS.2010.5690690 PG 6 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA BTS59 UT WOS:000287982100039 ER PT S AU Edelstein, AS Fischer, GA Fine, JE Viehland, D AF Edelstein, Alan S. Fischer, Greg A. Fine, Jonathan E. Viehland, Dwight GP IEEE TI Approach for sub pT, Room Temperature Magnetic Sensors SO 2010 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 2010 IEEE Sensors Conference CY NOV 01-04, 2010 CL Kona, HI SP IEEE AB Some of the major contributions to noise in magnetic sensors can only be reduced by increasing the size of the sensor. Here we present an approach for reducing 1/f noise in large magnetic sensors. The approach is based on modulating the field by rotating a disc containing permalloy flux concentrators or flux guides. The disc rotation is driven by an air turbine. Modulation frequencies as high as 76 Hz have been achieved, but higher modulation frequencies will be achieved in our new design. Low frequency signals appear as sidebands around the modulation frequency. The magnetic sensor used is a magnetoelectric sensor. Magnetoelectric sensors have achieved sensitivities of 2nT at 1 Hz. By using modulation to operate at the mechanical resonance frequency of magnetoelectric sensors it should be possible to achieve sub pT/Hz(1/2) at 1 Hz. Here we discuss the progress and problems in achieving this goal. C1 [Edelstein, Alan S.; Fischer, Greg A.; Fine, Jonathan E.] USA, Res Lab, Adelphi, MD 20783 USA. [Viehland, Dwight] Virgina Tech Univ, Blacksburg, VA 24061 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM alan.edelstein@us.army.mil FU DARPA FX Supported by DARPA in their HUMS program NR 5 TC 1 Z9 1 U1 1 U2 11 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4244-8168-2 J9 IEEE SENSOR PY 2010 BP 620 EP 622 DI 10.1109/ICSENS.2010.5690118 PG 3 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA BTS59 UT WOS:000287982100135 ER PT S AU Edelstein, AS Fischer, GA Egelhoff, W Burnette, JE AF Edelstein, A. S. Fischer, G. A. Egelhoff, Wm., Jr. Burnette, J. E. GP IEEE TI MEMS Approach for Making a Low Cost, High Sensitivity Magnetic Sensor SO 2010 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 2010 IEEE Sensors Conference CY NOV 01-04, 2010 CL Kona, HI SP IEEE ID ROOM-TEMPERATURE; MAGNETORESISTANCE AB An approach based on electromechanical systems (MEMS) technology will be presented that essentially eliminates the problem of 1/f noise in small magnetic sensors. The sensor based on this approach, the MEMS flux concentrator sensor, should outperform all other high sensitivity vector magnetometers in terms of cost, power consumption, and sensitivity. The method for achieving this improvement is to employ flux concentrators on MEMS structures that are near the magnetic sense element. The motion of the flux concentrators modulates the magnetic field and shifts the operating frequency of the sensor to higher frequencies where 1/f noise is unimportant. The data presented here provides our first evidence that the MEMS flux concentrator improves the signal to noise ratio at low frequencies. C1 [Edelstein, A. S.; Fischer, G. A.] USA, Res Lab, Adelphi, MD 20782 USA. [Egelhoff, Wm., Jr.; Burnette, J. E.] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA. RP Edelstein, AS (reprint author), USA, Res Lab, Adelphi, MD 20782 USA. EM alan.edelstein@us.army.mil NR 14 TC 0 Z9 0 U1 0 U2 10 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4244-8168-2 J9 IEEE SENSOR PY 2010 BP 2149 EP 2152 DI 10.1109/ICSENS.2010.5690534 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA BTS59 UT WOS:000287982100473 ER PT S AU Polcawich, RG Pulskamp, JS Bedair, S Smith, G Kaul, R Kroninger, C Wetzel, E Chandrahalim, H Bhave, SA AF Polcawich, Ronald G. Pulskamp, Jeffrey S. Bedair, Sarah Smith, Gabriel Kaul, Roger Kroninger, Chris Wetzel, Eric Chandrahalim, Hengky Bhave, Sunil A. GP IEEE TI Integrated PiezoMEMS Actuators and Sensors SO 2010 IEEE SENSORS SE IEEE Sensors LA English DT Proceedings Paper CT 2010 IEEE Sensors Conference CY NOV 01-04, 2010 CL Kona, HI SP IEEE AB The ability to combine both actuation and sensing technologies into one unified MEMS fabrication process is enabling for a wide variety of applications including high frequency filters, transformers and mm-scale robotics. This research demonstrates piezoelectric MEMS (PiezoMEMS) devices based on lead zirconate titanate (PZT) thin films including switchable resonators, transformers, and microflight actuators with integrated strain sensors. PiezoMEMS resonators and transformers combine actuation and sensing on a single device platform. Current research on PZT based resonators is focused on optimizing the performance for both high quality factor, Q, and low motional resistance. Resonators in the low tens of MHz can also be utilized as piezoelectric resonant transformers and are predicted to achieve AC/DC gains in the range of 2 to 8. In addition, strain sensors positioned at the cantilever root of PiezoMEMS microflight actuators provide direct feedback of the motional response of the actuated wing. C1 [Polcawich, Ronald G.; Pulskamp, Jeffrey S.; Bedair, Sarah; Smith, Gabriel; Kaul, Roger; Kroninger, Chris; Wetzel, Eric] USA, Res Lab, RF & Elect Div, Adelphi, MD 20783 USA. [Chandrahalim, Hengky; Bhave, Sunil A.] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. RP Polcawich, RG (reprint author), USA, Res Lab, RF & Elect Div, Adelphi, MD 20783 USA. EM ronald.g.polcawich@us.army.mil; sunil@ece.cornell.edu RI Bedair, Sarah/D-9130-2013; Chandrahalim, Hengky/F-1475-2016 OI Chandrahalim, Hengky/0000-0003-1930-1359 NR 10 TC 2 Z9 2 U1 0 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1930-0395 BN 978-1-4244-8168-2 J9 IEEE SENSOR PY 2010 BP 2193 EP 2196 DI 10.1109/ICSENS.2010.5690603 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA BTS59 UT WOS:000287982100486 ER PT J AU Baidas, MW Lai, HQ Liu, KJR AF Baidas, Mohammed W. Hung-Quoc Lai Liu, K. J. Ray GP IEEE TI Many-to-Many Communications via Space-Time Network Coding SO 2010 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE (WCNC 2010) LA English DT Proceedings Paper CT IEEE Wireless Communications and Networking Conference (WCNC) CY APR 18-21, 2010 CL Sydney, AUSTRALIA SP IEEE DE Cooperation; decode-and-forward; diversity; many-to-many; symbol-error-rate; wireless network coding ID COOPERATIVE DIVERSITY; PERFORMANCE ANALYSIS; FADING CHANNELS AB In this paper, the mutual cooperative communication between multiple nodes in a wireless network is efficiently achieved through a novel concept of Space-Time Network Coding (STNC). Unlike the conventional point-to-point cooperative communications between two nodes with N relay nodes deployed in between, simultaneous transmissions from the different N nodes acting as source/relay nodes are performed within 2N time-slots. In particular, the communication is split into two phases: 1) Broadcasting Phase and 2) Cooperation Phase. In the Broadcasting Phase, each node broadcasts its data symbol to the other nodes in the network in its own time-slot, alternatively; while in the Cooperation Phase, in each time-slot, a set of (N - 1) nodes transmit while a single destination node receives the other nodes' transmissions. Specifically, each node employing a selective Decode-and-Forward (DF) cooperative protocol, performs a linear combination of the other nodes data symbols and all the (N - 1) nodes simultaneously transmit their signals to a single receiving node; which then performs joint multiuser detection to separate the different nodes' symbols. Exact symbol-error-rate (SER) expressions for arbitrary order M-ary Phase Shift Keying (M-PSK) modulation are derived. In addition, an asymptotic SER approximation is also provided which is shown to be tight at high signal-to-noise ratio (SNR). Finally, the analytical results confirm that for a network of N nodes, a full diversity order of (N - 1) per node is achieved by the proposed STNC cooperative communication scheme. C1 [Baidas, Mohammed W.; Liu, K. J. Ray] Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. [Hung-Quoc Lai] US Army, RDECOM CERDEC, RDER STW NA, Aberdeen Proving Ground, MD 21005 USA. RP Baidas, MW (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM baidas@ieee.org; hungquoc.lai@us.army.mil; kjrliu@umd.edu NR 13 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-6398-5 PY 2010 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BYL10 UT WOS:000299203101083 ER PT J AU Liu, CH He, T Lee, KW Leung, KK Swami, A AF Liu, Chi Harold He, Ting Lee, Kang-won Leung, Kin K. Swami, Ananthram GP IEEE TI Dynamic Control of Data Ferries under Partial Observations SO 2010 IEEE WIRELESS COMMUNICATIONS AND NETWORKING CONFERENCE (WCNC 2010) LA English DT Proceedings Paper CT IEEE Wireless Communications and Networking Conference (WCNC) CY APR 18-21, 2010 CL Sydney, AUSTRALIA SP IEEE AB Controlled mobile helper nodes called data ferries have recently been proposed to bridge communications between disconnected nodes in a delay-tolerant manner. While existing work has explored various trajectory designs for the data ferry by assuming either static nodes or full observations at the data ferry, the problem remains open when the nodes are mobile and the ferry only has partial observations. In this paper, we investigate the problem of dynamic ferry mobility control under limited-range sensing. Assuming the data ferries are capable of sensing node presence within certain range and adjust their movements dynamically, we aim to design control policies that maximize the number of effective contacts. We provide a comprehensive model of the control framework using Partially Observable Markov Decision Process (POMDP), based on which we study the structure of the optimal policy and propose an efficient heuristic policy which shows significant improvement over the predetermined benchmark. To the best of our knowledge, this is the first data ferry control mechanism that can handle both stochastic node mobility and incomplete ferry observations. C1 [Liu, Chi Harold; Leung, Kin K.] Univ London Imperial Coll Sci Technol & Med, London, England. [Swami, Ananthram] Army Res Lab, Adelphia, MD USA. [He, Ting; Lee, Kang-won] IBM T J Watson Res Ctr, Hawthorne, NY USA. RP Liu, CH (reprint author), Univ London Imperial Coll Sci Technol & Med, London, England. EM chiliu@imperial.ac.uk; the@us.ibm.com; kangwon@us.ibm.com; kin.leung@imperial.ac.uk; aswami@arl.army.mil FU U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX Research was sponsored by the U.S. Army Research Laboratory and the U.K. Ministry of Defence and was accomplished under Agreement Number W911NF-06-3-0001. NR 10 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-6398-5 PY 2010 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BYL10 UT WOS:000299203102005 ER PT J AU Nayfeh, OM Dubey, M AF Nayfeh, Osama M. Dubey, Madan GP IEEE TI Large Area CVD Monolayer Graphene for Nanoelectronics: Device Performance and Analysis SO 2010 INTERNATIONAL CONFERENCE ON MICROELECTRONICS SE International Conference on Microelectronics-ICM LA English DT Proceedings Paper CT 22nd International Conference on Microelectronics (ICM 2010) CY DEC 19-22, 2010 CL Cairo, EGYPT SP IEEE ID FILMS AB Graphene transistors using large area CVD monolayer graphene are constructed and examined. Backgated devices with exposed graphene channels are characterized to shed light on some of the apparent doping and transport effects that could impact the device performance. Electrical measurements under vacuum and soft-anneal conditions are used to modulate the effective doping density and carrier mobility for both electrons and holes. A good agreement between measurements and a simple drift-diffusion model is obtained when modeling this CVD graphene with a net p-type doping and asymmetric electron/hole mobility. An extracted mean-free path for scattering suggests the presence of large levels of Coulomb and short-range scattering which could be limiting the mobility in this doped material. The results are of importance for understanding the potential of large-area CVD graphene for use in future radiofrequency devices. C1 [Nayfeh, Osama M.; Dubey, Madan] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Nayfeh, OM (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM osama.nayfeh@us.army.mil; madan.dubey@us.army.mil NR 17 TC 0 Z9 0 U1 1 U2 6 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-61284-151-9 J9 INT C MICROELECTRON PY 2010 BP 232 EP 235 DI 10.1109/ICM.2010.5696125 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BUX58 UT WOS:000290617900059 ER PT S AU Venugopal, SM Allee, DR Quevedo-Lopez, M Gnade, B Forsythe, E Morton, D AF Venugopal, Sameer M. Allee, David R. Quevedo-Lopez, Manuel Gnade, Bruce Forsythe, Eric Morton, David GP IEEE TI Flexible Electronics: What can it do? What should it do? SO 2010 INTERNATIONAL RELIABILITY PHYSICS SYMPOSIUM SE International Reliability Physics Symposium LA English DT Proceedings Paper CT 48TH Annual IEEE International Reliability Physics Symposium (IRPS) CY MAY 02-06, 2010 CL Anaheim, CA SP IEEE DE flexible electronics; thin film transistors ID THIN-FILM TRANSISTORS; SILICON; DISPLAYS AB The development of low temperature, thin film transistor processes that has enabled flexible displays also presents opportunities for flexible electronics. A variety of flexible digital and analog electronics have been demonstrated, although typically of modest performance. We review the state-of-the-art in flexible electronics followed by a discussion of the constraints, remaining challenges and realistic potential applications of thin film transistors and flexible integrated systems. C1 [Venugopal, Sameer M.; Allee, David R.] Arizona State Univ, Flexible Display Ctr, 7700 S River Pkwy, Tempe, AZ 85284 USA. [Quevedo-Lopez, Manuel; Gnade, Bruce] Univ Texas Dallas, Dept Mat Sci & Engn, Richardson, TX 75083 USA. [Forsythe, Eric; Morton, David] US Army, Res Lab, MS AMSRD ARL SE EO, Adelphi, MD 20783 USA. RP Venugopal, SM (reprint author), Arizona State Univ, Flexible Display Ctr, 7700 S River Pkwy, Tempe, AZ 85284 USA. EM sameermv@asu.edu RI Gnade, Bruce/C-2327-2008 FU U.S Army Research Labs; Flexible Display Center at Arizona State University FX We would like to acknowledge U.S. Army Research Labs for their continued support and funding for the development flexible electronics and displays at Flexible Display Center at Arizona State University NR 31 TC 4 Z9 4 U1 2 U2 20 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1541-7026 BN 978-1-4244-5431-0 J9 INT RELIAB PHY SYM PY 2010 BP 644 EP 649 DI 10.1109/IRPS.2010.5488757 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA BTO50 UT WOS:000287515600105 ER PT S AU Khalili, R Goeckel, DL Towsley, D Swami, A AF Khalili, Ramin Goeckel, Dennis L. Towsley, Don Swami, Ananthram GP IEEE TI Neighbor discovery with reception status feedback to transmitters SO 2010 PROCEEDINGS IEEE INFOCOM SE IEEE INFOCOM LA English DT Proceedings Paper CT Conference on IEEE INFOCOM CY MAR 15-19, 2010 CL San Diego, CA SP IEEE ID ALGORITHM AB Neighbor discovery is essential for the process of self-organization of a wireless network, where almost all routing and medium access protocols need knowledge of one-hop neighbors. In this paper we study the problem of neighbor discovery in a static and synchronous network, where time is divided into slots, each of duration equal to the time required to transmit a hello message, and potentially, some sort of feedback message. Our main contributions lie in detailing the physical layer mechanism for how nodes in receive mode detect the channel status, describing algorithms at higher layers that exploit such a knowledge, and characterizing the significant gain obtained. In particular, we describe one possible physical layer architecture that allows receivers to detect collisions, and then introduce a feedback mechanism that makes the collision information available to the transmitters. This allows nodes to stop transmitting packets as soon as they learn about the successful reception of their discovery messages by the other nodes in the network. Hence, the number of nodes that need to transmit packets decreases over time. These nodes transmit with a probability that is inversely proportional to the number of active nodes in their neighborhood, which is estimated using the collision information available at the nodes. We show through analysis and simulations that our algorithm allows nodes to discover their neighbors in a significantly smaller amount of time compared to the case where reception status feedback is not available to the transmitters. C1 [Khalili, Ramin] EPFL IC LCA, Lausanne, Switzerland. [Goeckel, Dennis L.] UMASS, ECE Dept, Amherst, MA USA. [Towsley, Don] UMASS, CS Dept, Amherst, MA USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD USA. RP Khalili, R (reprint author), EPFL IC LCA, Lausanne, Switzerland. EM ramin.khalili@epfl.ch; goeckel@ecs.umass.edu; towsley@cs.umass.edu; a.swami@ieee.org FU NSF [CNS-072186]; NCCR-MICS-Swiss National Science Foundation; International Technology Alliance; U.S. Army Research Laboratory; U.K. Ministry of Defence [W911NF-06-3-0001] FX This work was supported in part by the NSF under grant CNS-072186, by NCCR-MICS (a center supported by the Swiss National Science Foundation), and the International Technology Alliance sponsored by the U.S. Army Research Laboratory and the U.K. Ministry of Defence under Agreement Number W911NF-06-3-0001.- NR 17 TC 0 Z9 0 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-166X BN 978-1-4244-5838-7 J9 IEEE INFOCOM SER PY 2010 PG 9 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BTN69 UT WOS:000287416300165 ER PT S AU Lu, Z Wang, WY Wang, C AF Lu, Zhuo Wang, Wenye Wang, Cliff GP IEEE TI On Order Gain of Backoff Misbehaving Nodes in CSMA/CA-based Wireless Networks SO 2010 PROCEEDINGS IEEE INFOCOM SE IEEE INFOCOM LA English DT Proceedings Paper CT Conference on IEEE INFOCOM CY MAR 15-19, 2010 CL San Diego, CA SP IEEE ID PERFORMANCE AB Backoff misbehavior, in which a wireless node deliberately manipulates its backoff time, can induce significant network problems, such as severe unfairness and denial-of-service. Although great progress has been made towards the design of countermeasures to backoff misbehavior, little attention has been focused on quantifying the gain of backoff misbehaviors. In this paper, we define and study two general classes of backoff misbehavior to assess the gain that misbehaving nodes can obtain. The first class, called continuous misbehavior, keeps manipulating the backoff time unless it is disabled by countermeasures. The second class is referred to as intermittent misbehavior, which tends to evade the detection by countermeasures by performing misbehavior sporadically. Our approach is to introduce a new performance metric, namely order gain, which is to characterize the performance benefits of misbehaving nodes in comparison to legitimate nodes. Through analytical studies, simulations, and experiments, we demonstrate the impact of a wide range of backoff misbehaviors on network performance with respect to the number of users in CSMA/CA-based wireless networks. C1 [Lu, Zhuo; Wang, Wenye] North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. [Wang, Cliff] US Army, Res Off, Res Triangle Pk, NC 27709 USA. RP Lu, Z (reprint author), North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA. EM zlu3@ncsu.edu; wwang@ncsu.edu; cliff.wang@us.army.mil NR 15 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0743-166X BN 978-1-4244-5838-7 J9 IEEE INFOCOM SER PY 2010 PG 9 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic; Telecommunications SC Computer Science; Engineering; Telecommunications GA BTN69 UT WOS:000287416300103 ER PT S AU Wood, RA Urciuoli, DP Salem, TE Green, R AF Wood, R. A. Urciuoli, D. P. Salem, T. E. Green, R. GP IEEE TI Reverse Conduction of a 100 A SiC DMOSFET Module in High-Power Applications SO 2010 TWENTY-FIFTH ANNUAL IEEE APPLIED POWER ELECTRONICS CONFERENCE AND EXPOSITION (APEC) SE Annual IEEE Applied Power Electronics Conference and Exposition (APEC) LA English DT Proceedings Paper CT 25th Annual IEEE Applied Power Electronics Conference and Exposition CY FEB 21-25, 2010 CL Palm Springs, CA SP IEEE ID VEHICLES AB Numerous research efforts over the past few years have documented the enhanced capabilities that Silicon Carbide (SiC) offers over Silicon based power electronic devices. Additional research work has led to vast improvements in the manufacturing of SiC based components. As a result, SiC power electronic components, primarily diodes, are now readily available and this technology promises to have widespread market impact as more complex device structures are commercially realized. Recently, the development of a 1200 V 50 A SiC DMOSFET device and its use in a 100 A power module has been documented [1]. This paper extends that research work to report on the reverse conduction characteristics of the SiC DMOSFET and the system-level benefits for high-power applications that can be achieved by operating these devices in this manner. Experimental data is presented on the 100 A module consisting of two, 50 A SiC DMOSFETs and two, 50 A SiC JBS anti-parallel free-wheeling diodes used in a high-power bi-directional DC-DC converter during buck mode operation. C1 [Wood, R. A.; Urciuoli, D. P.; Green, R.] USA, Res Lab, Adelphi, MD USA. RP Wood, RA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD USA. NR 12 TC 7 Z9 7 U1 0 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1048-2334 BN 978-1-4244-4783-1 J9 APPL POWER ELECT CO PY 2010 BP 1568 EP 1571 DI 10.1109/APEC.2010.5433440 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA BOZ70 UT WOS:000278142300247 ER PT J AU Pelaez, JC AF Pelaez, Juan C. GP Knowledge Syst Inst TI A Pattern Methodology for Modeling Network Forensic Investigations in Converged Tactical Environments SO 22ND INTERNATIONAL CONFERENCE ON SOFTWARE ENGINEERING & KNOWLEDGE ENGINEERING (SEKE 2010) LA English DT Proceedings Paper CT 22nd International Conference on Software Engineering and Knowledge Engineering (SEKE) CY JUL 01-03, 2010 CL Redwood, CA SP Knowledge Syst Inst Grad Sch DE Voice over IP; tactical networks; semi-formal patterns; network forensics; network architecture AB Voice over IP over Wireless (VoIPoW) has had a strong effect on tactical networking by allowing human voice and video to travel over existing packet data networks along with traditional data packets. The U.S. Army is using IP telephony on high level units and it is expected that this technology will be fully implemented all the way from combat units to division level within the next lustrum. The implementation of wireless VoIP technology in the battlefield brings both network architecture and forensic challenges to the warfighter. This paper discusses the main challenges associated with security investigations in converged networks. Further, this research attempts to improve tactical Internetworking security by proposing a VoIP pattern system in order to create a UML Network Forensic Model for a simplified VoIP tactical environment. The pattern system will allow examiners to specify, analyze and implement network security investigations for different architectures. C1 [Pelaez, Juan C.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Pelaez, JC (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM juan.c.pelaez@arl.army.mil NR 13 TC 0 Z9 0 U1 0 U2 0 PU KNOWLEDGE SYSTEMS INSTITUTE PI SKOKIE PA 3420 MAIN ST, SKOKIE, IL 60076 USA BN 978-1-891706-26-4 PY 2010 BP 777 EP 782 PG 6 WC Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA BG7XA UT WOS:000391891600144 ER PT S AU Sharar, DJ Jankowski, NR Morgan, B AF Sharar, Darin J. Jankowski, Nicholas R. Morgan, Brian GP IEEE TI Thermal Performance of a Direct-Bond-Copper Aluminum Nitride Manifold-Microchannel Cooler SO 26TH ANNUAL IEEE SEMICONDUCTOR THERMAL MEASUREMENT AND MANAGEMENT SYMPOSIUM, PROCEEDINGS 2010 SE Proceedings IEEE Semiconductor Thermal Measurement and Management Symposium LA English DT Proceedings Paper CT 26th Annual IEEE Semiconductor Thermal Measurement and Management Symposium CY FEB 21-25, 2010 CL Santa Clara, CA SP IEEE, CPMT, NIST AB The presence of multiple thermally resistive layers in a standard power electronics package is a hindrance to thermal dissipation. By reducing the thermal stack and incorporating microchannel cold plates into the Aluminum Nitride substrate layer, significant improvement can be made. While parallel microchannel coolers have proved their faculty for single chip cooling, manifold microchannel coolers are explored for projected thermal and fluidic advantages for multi-chip modules aimed towards Hybrid Electric vehicles. This report outlines the fabrication, testing, and experimental results for a four-chip manifold microchannel cooler with water at 25 degrees C and 80 degrees C and three vehicular coolant fluids at 80 degrees C with a maximum allowable pressure drop of 5 psig. Depending on the coolant fluid used, the total thermal stack resistivities ranged from 0.316-0.628 K-cm(2)/W at the 5psig pressure limit. Potential for future research and module improvement is briefly discussed. C1 [Sharar, Darin J.; Jankowski, Nicholas R.; Morgan, Brian] USA, Res Lab, Adelphi, MD 20783 USA. RP Sharar, DJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM darin.sharar@arl.army.mil NR 14 TC 9 Z9 9 U1 0 U2 4 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1065-2221 BN 978-1-4244-6458-6 J9 P IEEE SEMICOND THER PY 2010 BP 68 EP 73 DI 10.1109/STHERM.2010.5444313 PG 6 WC Thermodynamics; Engineering, Electrical & Electronic SC Thermodynamics; Engineering GA BTM83 UT WOS:000287362700010 ER PT S AU Boteler, L Urciuoli, D Ovrebo, G Ibitayo, D Green, R AF Boteler, Lauren Urciuoli, Damian Ovrebo, Gregory Ibitayo, Dimeji Green, Ronald GP IEEE TI Thermal Performance of a Dual 1.2 kV, 400 A Silicon-Carbide MOSFET Power Module SO 26TH ANNUAL IEEE SEMICONDUCTOR THERMAL MEASUREMENT AND MANAGEMENT SYMPOSIUM, PROCEEDINGS 2010 SE Proceedings IEEE Semiconductor Thermal Measurement and Management Symposium LA English DT Proceedings Paper CT 26th Annual IEEE Semiconductor Thermal Measurement and Management Symposium CY FEB 21-25, 2010 CL Santa Clara, CA SP IEEE, CPMT, NIST DE Silicon carbide; thermal performance; power module; MOSFET; thermal modeling AB Power electronics are reaching the temperature limits of silicon; therefore alternative materials such as silicon carbide (SiC) are currently being explored. An all SiC 1.2 kV, 400 A dual MOSFET power module has been fabricated and tested for thermal performance. The module was designed as a drop-in replacement for standard commercial modules with an integrated liquid cooling system that reduces thermal resistance. The heat sink has been experimentally tested up to 400 A (158 W/cm(2)) showing a device temperature rise of as little as 24 degrees C. Thermal modeling was also performed and the results were compared to experimental data. C1 [Boteler, Lauren; Urciuoli, Damian; Ovrebo, Gregory; Ibitayo, Dimeji; Green, Ronald] USA, Res Lab, Power Components Branch, Adelphi, MD 20783 USA. RP Boteler, L (reprint author), USA, Res Lab, Power Components Branch, Adelphi, MD 20783 USA. EM lauren.boteler@arl.army.mil NR 4 TC 8 Z9 8 U1 1 U2 1 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1065-2221 BN 978-1-4244-6458-6 J9 P IEEE SEMICOND THER PY 2010 BP 170 EP 175 DI 10.1109/STHERM.2010.5444297 PG 6 WC Thermodynamics; Engineering, Electrical & Electronic SC Thermodynamics; Engineering GA BTM83 UT WOS:000287362700025 ER PT S AU Long, JB Tong, L Bauman, RA Atkins, JL Januszkiewicz, AJ Riccio, C Gharavi, R Shoge, R Parks, S Ritzel, DV Bentley, TB AF Long, J. B. Tong, L. Bauman, R. A. Atkins, J. L. Januszkiewicz, A. J. Riccio, C. Gharavi, R. Shoge, R. Parks, S. Ritzel, D. V. Bentley, T. B. BE Herold, KE Bentley, WE Vossoughi, J TI Blast-Induced Traumatic Brain Injury: Using a Shock Tube to Recreate a Battlefield Injury in the Laboratory SO 26TH SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE: SBEC 2010 SE IFMBE Proceedings LA English DT Proceedings Paper CT 26th Southern Biomedical Engineering Conference, SBEC 2010 CY APR 30-MAY 02, 2010 CL Univ Maryland, College Park, MD SP Natl Sci Fdn, Biomed Engn Soc Chongqing, Natl Canc Inst (NCI) HO Univ Maryland DE blast; traumatic brain injury; shock tube; shock wave; simulation; blast overpressure ID OVERPRESSURE INJURY; EXPLOSIVE BLAST; NEUROTRAUMA; MODEL; RATS AB Explosive detonation has been a longstanding battlefield concern for the U.S. Army. Recently, emphasis has shifted to blast injury to the brain since blast has emerged as the predominant cause of neurotrauma in current military conflicts, and its etiology is largely undefined. Using a compression-driven shock tube to simulate blast, we are assessing the physiological, neuropathological, and neurobehavioral consequences of airblast exposure. Blast generates an air shock front imparting effectively instantaneous increases in static and dynamic pressure conditions. The positioning of the experimental subject within the shock tube greatly influences the exposure conditions and determines the relative contributions of these side-on and dynamic pressures to the injury. The pressure exposures and brain injuries resulting from airblast exposure at different shock tube positions are reviewed. Shock tube exposures provide survivable blast conditions under which striking neuropathological changes can be generated and TBI can be studied. These findings demonstrate that shock tube-generated airblast can cause TBI in rats, and point to the utility of this experimental tool in the development of effective therapies and countermeasures. C1 [Long, J. B.; Tong, L.; Bauman, R. A.; Atkins, J. L.; Januszkiewicz, A. J.; Riccio, C.; Gharavi, R.; Shoge, R.; Bentley, T. B.] Walter Reed Army Inst Res, Div Brain Dysfunct & Blast Injury, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. [Parks, S.] Operat Res Applicat, Fredericksburg, VA 22408 USA. [Ritzel, D. V.] Dyn FX Consulting Ltd, Amherstburg, ON N9V2T5, Canada. RP Long, JB (reprint author), Walter Reed Army Inst Res, Div Brain Dysfunct & Blast Injury, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM joseph.long@amedd.army.mil FU CDMRP [W81XWH-08-2-0018, W81XWH-08-2-0017] FX The expert technical assistance of Eloyse Fleming, Angela Dalmolin, and Andrea Edwards is gratefully acknowledged. Supported by CDMRP Awards W81XWH-08-2-0018 and W81XWH-08-2-0017. NR 13 TC 3 Z9 3 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1680-0737 BN 978-3-642-14997-9 J9 IFMBE PROC PY 2010 VL 32 BP 26 EP + PG 3 WC Engineering, Biomedical SC Engineering GA BBO72 UT WOS:000307744700007 ER PT S AU Zahedi, S Srivastava, MB Bisdikian, C Kaplan, LM AF Zahedi, Sadaf Srivastava, Mani B. Bisdikian, Chatschik Kaplan, Lance M. BE Brandt, S TI Quality Tradeoffs in Object Tracking with Duty-Cycled Sensor Networks SO 31ST IEEE REAL-TIME SYSTEMS SYMPOSIUM (RTSS 2010) SE Real-Time Systems Symposium-Proceedings LA English DT Proceedings Paper CT 31st IEEE Real-Time Systems Symposium CY NOV 30-DEC 03, 2010 CL San Diego, CA SP IEEE Comp Soc, Tech Comm Real Time Sys AB Extending the lifetime of wireless sensor networks requires energy-conserving operations such as duty-cycling. However, such operations may impact the effectiveness of high-fidelity real-time sensing tasks, such as object tracking, which require high accuracy and short response times. In this paper, we quantify the influence of different duty-cycle schemes on the efficiency of bearings-only object tracking. Specifically, we use the Maximum Likelihood localization technique to analyze the accuracy limits of object location estimates under different response latencies considering variable network density and duty-cycle parameters. Moreover, we study the tradeoffs between accuracy and response latency under various scenarios and motion patterns of the object. We have also investigated the effects of different duty-cycled schedules on the tracking accuracy using acoustic sensor data collected at Aberdeen Proving Ground, Maryland, by the U. S. Army Research Laboratory (ARL).(1) C1 [Zahedi, Sadaf; Srivastava, Mani B.] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90024 USA. [Bisdikian, Chatschik] IBM Corp, T J Watson Res Ctr, Hawthorne, NY 10532 USA. [Kaplan, Lance M.] US Army Res Lab, Adelphi, MD 20783 USA. RP Zahedi, S (reprint author), Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90024 USA. EM szahedi@ee.ucla.edu; mbs@ee.ucla.edu; bisdik@us.ibm.com; lance.m.kaplan@us.army.mil FU US Army Research laboratory; UK Ministry of Defense [W911NF-06-3-0001] FX Research was sponsored by US Army Research laboratory and the UK Ministry of Defense and was accomplished under Agreement Number W911NF-06-3-0001. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the US Army Research Laboratory, the U.S. Government, the UK Ministry of Defense, or the UK Government. The US and UK Governments are authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. NR 15 TC 4 Z9 4 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA SN 1052-8725 BN 978-0-7695-4298-0 J9 REAL TIM SYST SYMP P PY 2010 BP 160 EP 169 DI 10.1109/RTSS.2010.24 PG 10 WC Computer Science, Theory & Methods SC Computer Science GA BTS37 UT WOS:000287965300015 ER PT S AU Ferguson, DC AF Ferguson, Dale C. GP IEEE TI SPACE SOLAR CELL EDGE, INTERCONNECT, AND COVERGLASS DESIGNS AND THEIR EFFECT ON SPACECRAFT CHARGING AND PLASMA INTERACTIONS SO 35TH IEEE PHOTOVOLTAIC SPECIALISTS CONFERENCE SE IEEE Photovoltaic Specialists Conference LA English DT Proceedings Paper CT 35th IEEE Photovoltaic Specialists Conference CY JUN 20-25, 2010 CL Honolulu, HI SP IEEE Elect Devices Soc, IEEE Photon Soc, IEEE Power & Energy Soc, Solar Energy Industries Assoc AB One of the principal design drivers for space solar arrays is solar cell arcing into the plasma due to spacecraft charging. The amount of spacecraft charging and the resulting differential voltages on space solar cell edges and interconnects is related to the cell edge, interconnect and coverglass designs. For example, the International Space Station (ISS) did not charge up to expected levels because of its closely spaced solar cells, wrap-through interconnects, and coverglass overhangs, which serve to choke off electron collection and prevent the concomitant negative charging that would otherwise occur on its high voltage solar arrays. Secondly, the occurrence of sustained arcing on solar arrays is related to the cell spacing and coverglass overhang. In this case, closely spaced solar array strings with little coverglass overhang may allow primary electrostatic discharges (ESDs) to transition into arcs between strings, which may continue until the entire solar array power is shorted. Thirdly, even primary ESDs have been shown to produce damage to some high efficiency triple junction solar cells by producing contaminants that can provide a conductive path between cell junctions, acting as a partial shunt resistance. Recently, novel solar cell types have been invented with structures at the cell edge, including buried junctions and stepped cell edges that may prevent damage from ESDs and sustained arcs. It is important that these designs be evaluated by spacecraft charging and current collection models to determine their effect on electron current collection, spacecraft charging, and solar array arcing. In this paper, we model standard, ISS-type, and new cell designs to determine whether the new cells help ameliorate solar cell arcing and/or damage due to the arcs. C1 USA, Res Lab, Albuquerque, NM 87117 USA. RP Ferguson, DC (reprint author), USA, Res Lab, Albuquerque, NM 87117 USA. NR 21 TC 1 Z9 1 U1 0 U2 5 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0160-8371 BN 978-1-4244-5891-2 J9 IEEE PHOT SPEC CONF PY 2010 BP 2537 EP 2542 DI 10.1109/PVSC.2010.5614609 PG 6 WC Energy & Fuels; Engineering, Electrical & Electronic SC Energy & Fuels; Engineering GA BTO69 UT WOS:000287579502173 ER PT S AU Brickey, J Walczak, S AF Brickey, Jon Walczak, Steven GP IEEE TI A Comparative Analysis of Professional Forums in the United States Army and Hybrid Communities of Practice in the Civilian Sector SO 43RD HAWAII INTERNATIONAL CONFERENCE ON SYSTEMS SCIENCES VOLS 1-5 (HICSS 2010) SE Proceedings of the Annual Hawaii International Conference on System Sciences LA English DT Proceedings Paper CT 43rd Hawaii International Conference on Systems Sciences (HICSS 2010) CY JAN 05-08, 2010 CL Honolulu, HI SP Univ Hawaii, Shidler Coll Business ID TECHNOLOGY; SYSTEMS AB Communities of practice (COPs) have been around since the founding of the first social networks many millennia ago Organizations around the world over the last two decades have leveraged COPs as tools in the knowledge management (KM) toolkit, however, the rules of the game have changed as the ubiquity of the Internet in organizations has led to profound changes in KM practices, including the rise of hybrid communities of practice (HCoPs), which combine both virtual and real world interaction between members. Whereas civilian organizations have adopted HCoPs and the adapted business unit structural changes associated with global collaboration, many have wondered how these changes would affect the US military and the Army in particular This paper is a comparative analysis of HCoPs in the Army and civilian organizations around the world Based on a review of HCoP typologies in civilian organizations. it classifies four Army HCoPs and compares them with civilian HCoPs and their associated challenges. strategies, and practices The study shows that the Army's implementation of HCoPs converges with that of the civilian sector, despite differences in organizational cultures, strategies, missions, and practices As has been the case throughout history, best practices are seldom kept secret, the Army and civilian organizations share best HCoP practices and learn from each other C1 [Brickey, Jon] USA, Washington, DC USA. [Walczak, Steven] Univ Colorado, Denver, CO USA. RP Brickey, J (reprint author), USA, Washington, DC USA. FU Center for the Advancement of Leader Development and Organizational Learning at the United States Military Academy FX We would like to thank the Center for the Advancement of Leader Development and Organizational Learning at the United States Military Academy for funding this research and providing feedback along the way. Additionally, we appreciate the time and patience of the professional forum facilitators and other Battle Command Knowledge System staff interviewed in this research. NR 29 TC 0 Z9 0 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 USA SN 1060-3425 BN 978-1-4244-5509-6 J9 P ANN HICSS PY 2010 BP 2947 EP + PG 3 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BRD18 UT WOS:000282391802119 ER PT B AU Liang, BT Urso, M Zambraski, E Jacobson, KA AF Liang, Bruce T. Urso, Maria Zambraski, Edward Jacobson, Kenneth A. BE Borea, PA TI Adenosine A(3) Receptors in Muscle Protection SO A3 ADENOSINE RECEPTORS FROM CELL BIOLOGY TO PHARMACOLOGY AND THERAPEUTICS LA English DT Article; Book Chapter ID HUMAN SKELETAL-MUSCLE; REPERFUSION INJURY; GENE-EXPRESSION; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; MESSENGER-RNA; MAST-CELLS; ISCHEMIA; ACTIVATION; INFARCTION C1 [Liang, Bruce T.] Univ Connecticut, Sch Med, Pat & Jim Calhoun Cardiovasc Ctr, Div Cardiol,Hlth Ctr, Farmington, CT 06030 USA. [Liang, Bruce T.] Univ Connecticut, Sch Med, Ctr Cardiovasc, Farmington, CT 06030 USA. [Urso, Maria; Zambraski, Edward] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Jacobson, Kenneth A.] NIDDK, Mol Recognit Sect, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA. RP Liang, BT (reprint author), Univ Connecticut, Sch Med, Pat & Jim Calhoun Cardiovasc Ctr, Div Cardiol,Hlth Ctr, 263 Farmington Ave, Farmington, CT 06030 USA. EM bliang@uchc.edu; maria.urso@us.army.mil; edward.zambraski@us.army.mil; kajacobs@helix.nih.gov OI Urso, Maria/0000-0001-8906-4673; Jacobson, Kenneth/0000-0001-8104-1493 NR 54 TC 9 Z9 9 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-90-481-3143-3 PY 2010 BP 257 EP 280 DI 10.1007/978-90-481-3144-0_13 D2 10.1007/978-90-481-3144-0 PG 24 WC Cell Biology; Pharmacology & Pharmacy SC Cell Biology; Pharmacology & Pharmacy GA BMQ78 UT WOS:000273356400013 ER PT B AU Giuliani, JR Kilcoyne, KG Rue, JPH AF Giuliani, Jeffrey R. Kilcoyne, Kelly G. Rue, John-Paul H. BE Bach, BR Provencher, MT TI ANATOMY IMPORTANT FOR SUCCESSFUL ACL RECONSTRUCTION SO ACL SURGERY: HOW TO GET IT RIGHT THE FIRST TIME AND WHAT TO DO IF IT FAILS LA English DT Article; Book Chapter ID ANTERIOR CRUCIATE LIGAMENT; FEMORAL TUNNEL PLACEMENT; IN-SITU FORCES; PATELLAR TENDON; POSTEROLATERAL BUNDLES; CORONAL PLANE; TIBIAL TUNNEL; SINGLE-BUNDLE; INTERCONDYLAR NOTCH; GRAFTS C1 [Giuliani, Jeffrey R.; Kilcoyne, Kelly G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Rue, John-Paul H.] USN Acad, Annapolis, MD 21402 USA. RP Giuliani, JR (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 46 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-55642-895-1 PY 2010 BP 9 EP 17 PG 9 WC Surgery SC Surgery GA BPE41 UT WOS:000278696100002 ER PT B AU DeBerardino, TM Bojescul, JA AF DeBerardino, Thomas M. Bojescul, John A. BE Bach, BR Provencher, MT TI MANAGEMENT OF THE VARUS-ALIGNED KNEE WITH A FAILED ACL Role of Osteotomy SO ACL SURGERY: HOW TO GET IT RIGHT THE FIRST TIME AND WHAT TO DO IF IT FAILS LA English DT Article; Book Chapter ID HIGH TIBIAL OSTEOTOMY; CRUCIATE LIGAMENT; RECONSTRUCTION; BIOMECHANICS; SURGERY; WEDGE C1 [DeBerardino, Thomas M.] UConn Hlth Ctr, Dept Orthopaed Surg, Storrs, CT USA. [DeBerardino, Thomas M.] UConn Athlet, Storrs, CT USA. [Bojescul, John A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA. RP DeBerardino, TM (reprint author), UConn Hlth Ctr, Dept Orthopaed Surg, Storrs, CT USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-55642-895-1 PY 2010 BP 287 EP 296 PG 10 WC Surgery SC Surgery GA BPE41 UT WOS:000278696100028 ER PT B AU Provencher, MT Lanzi, J Rose, M Solomon, DJ AF Provencher, Matthew T. Lanzi, Joseph Rose, Matthew Solomon, Daniel J. BE Bach, BR Provencher, MT TI MANAGEMENT OF COMBINED MENISCAL AND ACL INSUFFICIENCY AFTER RECONSTRUCTION The Role of Meniscal Transplant SO ACL SURGERY: HOW TO GET IT RIGHT THE FIRST TIME AND WHAT TO DO IF IT FAILS LA English DT Article; Book Chapter ID ANTERIOR CRUCIATE LIGAMENT; ALLOGRAFT TRANSPLANTATION; FOLLOW-UP; TIBIAL PLATEAU; KNEE; MENISCECTOMY; GRAFT; STABILITY C1 [Provencher, Matthew T.] Uniformed Serv Univ Hlth Sci, San Diego, CA USA. [Rose, Matthew; Solomon, Daniel J.] USN, Dept Orthopaed Surg, San Diego Med Ctr, San Diego, CA 92152 USA. [Lanzi, Joseph] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Provencher, MT (reprint author), Uniformed Serv Univ Hlth Sci, San Diego, CA USA. NR 40 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE ROAD, THOROFARE, NJ 08086-9447 USA BN 978-1-55642-895-1 PY 2010 BP 297 EP 310 PG 14 WC Surgery SC Surgery GA BPE41 UT WOS:000278696100029 ER PT J AU Loeb, SC Britzke, ER AF Loeb, Susan C. Britzke, Eric R. TI Intra- and interspecific responses to Rafinesque's big-eared bat (Corynorhinus rafinesquii) social calls SO ACTA CHIROPTEROLOGICA LA English DT Article DE call playback; Corynorhinus rafinesquii; eavesdropping; echolocation; social calls ID SPEAR-NOSED BATS; INFORMATION-TRANSFER; ECHOLOCATION CALLS; ROOST SELECTION; PREY SELECTION; TEMPERATE ZONE; ACOUSTIC LURE; SENSORY BASIS; FOOD-HABITS; VESPERTILIONIDAE AB responses or understand the functions of these calls. We tested the response of Rafinesque's big-cared bats (Corynorhinus rafinesquii) to social calls as a possible method to increase capture success and to understand the function of social calls. We also tested if calls of bats within the range of the previously designated subspecies differed, if the responses of Rafinesque's big-eared bats varied with geographic origin of the calls, and if other species responded to the calls of C. rafinesquii. We recorded calls of Rafinesque's big-eared bats at two colony roost sites in South Carolina, USA. Calls were recorded while bats were in the roosts and as they exited. Playback sequences for each site were created by copying typical pulses into the playback file. Two mist nets were placed approximately 50-500 m from known roost sites; the net with the playback equipment served as the Experimental net and the one without the equipment served as the Control net. Call structures differed significantly between the Mountain and Coastal Plains populations with calls from the Mountains being of higher frequency and longer duration. Ten of 11 Rafinesque's big-eared bats were caught in the Control nets and, 13 of 19 bats of other species were captured at Experimental nets even though overall bat activity did not differ significantly between Control and Experimental nets. Our results suggest that Rafinesque's big-eared bats are not attracted to conspecifics' calls and that these calls may act as an intraspecific spacing mechanism during foraging. C1 [Loeb, Susan C.] Clemson Univ, USDA Forest Serv, So Res Stn, Dept Forestay & Nat Resources, Clemson, SC 29634 USA. [Britzke, Eric R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Loeb, SC (reprint author), Clemson Univ, USDA Forest Serv, So Res Stn, Dept Forestay & Nat Resources, Clemson, SC 29634 USA. EM sloeb@fs.fed.us FU Bat Conservation International; USDA Forest Service-Southern Research Station; USDA Forest Service-Savannah River [DE-IA09-00SR22188] FX Funding for this project was provided by Bat Conservation International, the USDA Forest Service-Southern Research Station, and the USDA Forest Service-Savannah River (Interagency Agreement DE-IA09-00SR22188). We thank Congaree National Park for providing housing; Mary Bunch for logistical support; Paul and Bobby White for access to Ledyard Mine; Charles Dachelet, Adrienne DeBiase, Caitlin McCaw, Lindy Steadman, and Mark Yates for assistance in the field; and Mark Ford, Erin Gillam, Matina Kalcounis-Ruppell, Leigh Stuemke, Stan Zarnoch, and two anonymous reviewers for helpful comments on earlier drafts. NR 50 TC 5 Z9 5 U1 1 U2 21 PU MUSEUM & INST ZOOLOGY PAS-POLISH ACAD SCIENCES PI WARSAW PA WILCZA STREET 64, 00-679 WARSAW, POLAND SN 1508-1109 EI 1733-5329 J9 ACTA CHIROPTEROL JI Acta Chiropt. PY 2010 VL 12 IS 2 BP 329 EP 336 DI 10.3161/150811010X537909 PG 8 WC Zoology SC Zoology GA 700VM UT WOS:000285772400007 ER PT J AU Chen, JH Lu, F Lim, CS Kim, JY Ahn, HJ Suh, IB Takeo, S Tsuboi, T Sattabongkot, J Han, ET AF Chen, Jun-Hu Lu, Feng Lim, Chae Seung Kim, Jung-Yeon Ahn, Heui-June Suh, In-Bum Takeo, Satoru Tsuboi, Takafumi Sattabongkot, Jetsumon Han, Eun-Taek TI Detection of Plasmodium vivax infection in the Republic of Korea by loop-mediated isothermal amplification (LAMP) SO ACTA TROPICA LA English DT Article DE Malaria; Plasmodium vivax; LAMP; Diagnosis; Republic of Korea ID FALCIPARUM-MALARIA; DIAGNOSIS; PARASITES; TESTS; PCR; DNA AB Loop-mediated isothermal amplification (LAMP) is a novel technique that rapidly amplifies target DNA in isothermal conditions. In a previous study, the sensitivities and specificities of LAMP microscopy, and nested PCR were compared in the context of rapid malaria detection. In the present study, LAMP detected vivax malaria parasites in 115 of 117 microscopically positive samples (sensitivity, 98.3%; 95% CI, 97.4-100%), which agreed well with the nested PCR results (sensitivity, 99.1%; 95% CI: 96.0-100%). No positive cases of malaria were detected by LAMP or nested PCR in 50 consecutive feverish patients other than malaria from malaria endemic areas. LAMP performed on DNA extracted from heat-treated blood had a sensitivity of 93.3% (28/30, 95% CI: 84.4-100%) and specificity of 100% (30/30, 95% CI: 100%). The present study shows that LAMP based assays have high sensitivity specificity and amplification efficiencies for Plasmodium vivax detection. The authors recommend that LAMP can be considered as a rapid nucleic acid amplification assay for the molecular diagnosis of P. vivax in both clinical laboratories and malaria clinics in areas where vivax malaria is endemic. (C) 2009 Elsevier B.V. All rights reserved. C1 [Chen, Jun-Hu; Lu, Feng; Han, Eun-Taek] Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, Gangwon Do, South Korea. [Chen, Jun-Hu] Zhejiang Acad Med Sci, Inst Parasit Dis, Hangzhou 310013, Peoples R China. [Lu, Feng] Jiangsu Inst Parasit Dis, Wuxi 214064, Peoples R China. [Lim, Chae Seung] Korea Univ, Coll Med, Dept Lab Med, Seoul 425707, South Korea. [Kim, Jung-Yeon] KCDC, Natl Inst Hlth, Dept Malaria & Parasit Dis, Seoul 122701, South Korea. [Ahn, Heui-June] Korea Inst Radiol & Med Sci, Dept Internal Med, Seoul 139706, South Korea. [Suh, In-Bum] Kangwon Natl Univ, Coll Med, Dept Lab Med, Chunchon 200701, South Korea. [Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. [Takeo, Satoru; Tsuboi, Takafumi] Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. RP Han, ET (reprint author), Kangwon Natl Univ, Coll Med, Dept Parasitol, Hyoja2 Dong, Chunchon 200701, Gangwon Do, South Korea. EM ethan@kangwon.ac.kr FU Korea Government (MOST) [R01-2007-000-11260-0] FX This work was supported by the Korean Science and Engineering Foundation (KOSEF) grant funded by the Korea Government (MOST) (No. R01-2007-000-11260-0). NR 21 TC 21 Z9 29 U1 3 U2 13 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X J9 ACTA TROP JI Acta Trop. PD JAN PY 2010 VL 113 IS 1 BP 61 EP 65 DI 10.1016/j.actatropica.2009.09.007 PG 5 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 534RX UT WOS:000272916100011 PM 19778519 ER PT J AU Dilworth, RL Willis, VJ Videtec, KM Garban, M Sapp, LG Weisbord, MR Szabo, F O'Neil, J Marsick, VJ Watkins, KE Janoff, S Rimanoczy, I AF Dilworth, Robert L. Willis, Verna J. Videtec, Karen M. Garban, Mariana Sapp, Lillie Graham Weisbord, Marvin R. Szabo, Fran O'Neil, Judy Marsick, Victoria J. Watkins, Karen E. Janoff, Sandra Rimanoczy, Isabel BE Dilworth, RL Boshyk, Y TI Action Learning through the Lens of Action Learners SO ACTION LEARNING AND ITS APPLICATIONS LA English DT Article; Book Chapter C1 [Dilworth, Robert L.; Sapp, Lillie Graham] USA, Management Staff Coll, Ft Belvoir, VA USA. [Videtec, Karen M.] Virginia Commonwealth Univ, Dept Fash Design & Merchandising, Richmond, VA USA. [Dilworth, Robert L.] Boston Univ, Overseas Program, Boston, MA 02215 USA. [Dilworth, Robert L.] CUNY John Jay Coll Criminal Justice, New York, NY 10019 USA. [Garban, Mariana] Chicago Chest Phys, Chicago, IL USA. [Garban, Mariana] Cty Hosp Vasului, Vasului, Romania. [Garban, Mariana] Emergency Dept Vaslui Cty, Vaslui, Romania. [Marsick, Victoria J.] Columbia Univ, New York, NY 10027 USA. [Marsick, Victoria J.] Teachers Coll, Dept Org & Leadership, JM Huber Inst Learning Org, New York, NY 10027 USA. [Rimanoczy, Isabel] Univ Belgrano, Masters Program, Buenos Aires, DF, Argentina. [Szabo, Fran] Univ Maryland, Masters Gen Adm, College Pk, MD 20742 USA. [Szabo, Fran] Univ Delaware, Hotel Restaurant & Inst Management Programs, Newark, DE 19716 USA. [Videtec, Karen M.] Univ Ballarat Outside Melbourne, Sch Business, Melbourne, Vic, Australia. [Videtec, Karen M.] VCUs Sch Design & Arts, Doha, Qatar. [Watkins, Karen E.] Univ Georgia, Coll Educ, Athens, GA 30602 USA. [Watkins, Karen E.] Univ Texas Austin, Grad Program Adult & Human Resource Dev Leadershi, Austin, TX 78712 USA. [Willis, Verna J.] Georgia State Univ, Atlanta, GA 30303 USA. [Willis, Verna J.] Univ Salford, Revans Ctr, Salford M5 4WT, Lancs, England. RP Dilworth, RL (reprint author), USA, Management Staff Coll, Ft Belvoir, VA USA. EM vwillis@gsu.edu; kmvidetic@vcu.edu; medlink57@yahoo.co.uk; Parousia@aol.com; mweisbord@furturesearch.net; fran.szabo@gmail.com; jaoniel@aol.com; marsick@exchange.tc.columbia.edu; kwatkins@uga.edu; sjanoff@futuresearch.net; irimanoc@aol.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU PALGRAVE PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE RG21 6XS, ENGLAND BN 978-0-23025-074-1 PY 2010 BP 195 EP 210 D2 10.1057/9780230250741 PG 16 WC Education & Educational Research SC Education & Educational Research GA BWI81 UT WOS:000293957000014 ER PT S AU Bennett, K Robertson, J AF Bennett, Kelly Robertson, James BE Gilbreath, GC Hawley, CT TI The Impact of the Data Archiving File Format on the Sharing of Scientific Data for Use in Popular Computational Environments SO ACTIVE AND PASSIVE SIGNATURES SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Active and Passive Signatures CY APR 08-09, 2010 CL Orlando, FL SP SPIE DE Multimodal signatures; archiving file formats; HDF5; XML; MATLAB; Octave; Python; computational performance AB The U.S. Army Research Laboratory (ARL) conducted an initial study on the performance of XML and HDF5 in three popular computational software environments, MATLAB, Octave, and Python, all of which use high-level scripting languages and computational software tools designed for computational processing. Although usable for sharing and exchanging data, the initial results of the study indicated XML has clear limitations in a computational environment. Popular computational tools are unable to handle very large XML formatted files, thus limiting processing of large XML archived data files. We show the breakdown points of XML formatted files for various popular computational tools and explore the performance dependencies of XML and HDF5 formatted files in popular computational environments on the hardware, operating system, and mathematical function. This study also explores the inverse file size relationship between HDF5 and XML data files. Several organizations, including ARL, use both XML and HDF5 for archiving and exchanging data. XML is best suited for storing "light" data (such as metadata) and HDF5 is best suited for storing "heavy" scientific data. Integrating and using both XML and HDF5 for data archiving offers the best solution for data providers and consumers to share information for computational and scientific purposes. C1 [Bennett, Kelly] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Bennett, K (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM kelly@arl.army.mil NR 15 TC 2 Z9 2 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8151-1 J9 PROC SPIE PY 2010 VL 7687 AR 76870F DI 10.1117/12.850609 PG 12 WC Computer Science, Interdisciplinary Applications; Optics SC Computer Science; Optics GA BSQ81 UT WOS:000285499700011 ER PT S AU Smith, C Edwards, J Fisher, A AF Smith, Clint Edwards, Jarrod Fisher, Andmorgan BE Gilbreath, GC Hawley, CT TI Laser Induced Fluorescence Lifetime Characterization of Bacillus Endospore Species using Time Correlated Single Photon Counting Analysis with the Multi-Exponential Fit Method SO ACTIVE AND PASSIVE SIGNATURES SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Active and Passive Signatures CY APR 08-09, 2010 CL Orlando, FL SP SPIE DE Bacillus Endospores; Fluorescence; Lifetime Decay; TCSPC ID TO-NOISE RATIO AB Rapid detection of biological material is critical for determining presence/absence of bacterial endospores within various investigative programs. Even more critical is that if select material tests positive for bacillus endospores then tests should provide data at the species level. Optical detection of microbial endospore formers such as Bacillus sp. can be heavy, cumbersome, and may only identify at the genus level. Data provided from this study will aid in characterization needed by future detection systems for further rapid breakdown analysis to gain insight into a more positive signature collection of Bacillus sp. Literature has shown that fluorescence spectroscopy of endospores could be statistically separated from other vegetative genera, but could not be separated among one another. Results of this study showed endospore species separation is possible using laser-induce fluorescence with lifetime decay analysis for Bacillus endospores. Lifetime decays of B. subtilis, B. megaterium, B. coagulans, and B. anthracis Sterne strain were investigated. Using the Multi-Exponential fit method data showed three distinct lifetimes for each species within the following ranges, 0.2-1.3 ns; 2.5-7.0 ns; 7.5-15.0 ns, when laser induced at 307 nm. The four endospore species were individually separated using principle component analysis (95% CI). C1 [Smith, Clint; Edwards, Jarrod; Fisher, Andmorgan] USA, Engineer Res & Dev Ctr, Geospatial Res & Engn Div, Alexandria, VA 22315 USA. RP Smith, C (reprint author), USA, Engineer Res & Dev Ctr, Geospatial Res & Engn Div, Alexandria, VA 22315 USA. EM clint.b.smith@usace.army.mil NR 14 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8151-1 J9 P SOC PHOTO-OPT INS PY 2010 VL 7687 AR 76870B DI 10.1117/12.849219 PG 6 WC Computer Science, Interdisciplinary Applications; Optics SC Computer Science; Optics GA BSQ81 UT WOS:000285499700008 ER PT S AU Bhatt, RT Fox, DS Ali, AA AF Bhatt, Ramakrishna T. Fox, Dennis S. Ali, Abdul-Aziz BE Zhu, D Lin, HT Mathur, S Ohji, T TI STRENGTH DEGRADING MECHANISMS IN PLASMA SPRAY COATED SILICON NITRIDE SO ADVANCED CERAMIC COATINGS AND INTERFACES V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 34th International Conference and Exposition on Advanced Ceramics and Composites (ICACC)/Symposium on Advanced Ceramic Coatings for Structural, Environmental and Functional Applications CY JAN 24-29, 2010 CL Daytona Beach, FL SP Amer Ceram Soc (ACerS), Engn Ceram Div (ECD) ID ENVIRONMENTAL BARRIER COATINGS; MULLITE COATINGS; CARBIDE; OXIDATION AB Two high temperature grades of monolithic silicon nitrides were coated with a plasma sprayed barium aluminum strontium silicate (BSAS) based environmental barrier coating (EBC). Their room temperature flexural strengths were then measured. The EBC coated specimens showed nearly 50% loss in strength. Various factors such as substrate preparation methods, plasma spray damage to the substrate, thermal residual stresses, and stress raisers influenced the strength. To determine the strength degrading mechanism, the role played by various phases of the coating process on the substrate strength has been examined, and maximum thermal residual stresses generated in the coating has been modeled. Results indicate that three different types of flaws related to the coating deposition process in combination with tensile residual stress cause strength degradation. Of these flaws, two can be eliminated by pre and post processing treatments, but well bonded splats cannot be avoided. The splats and preexisting flaws on the substrate surface act as a stress raiser due to imposed tensile thermal residual stress of the coating, and thus cause strength degradation. C1 [Bhatt, Ramakrishna T.] USA, Vehicle Technol Ctr, Res Lab, Glenn Res Ctr Lewis Field, 21000 Brookpk Rd, Cleveland, OH 44135 USA. [Fox, Dennis S.] Cleveland State Univ, Cleveland, OH USA. [Ali, Abdul-Aziz] NASA, Glenn Res Ctr, Cleveland, OH USA. RP Bhatt, RT (reprint author), USA, Vehicle Technol Ctr, Res Lab, Glenn Res Ctr Lewis Field, 21000 Brookpk Rd, Cleveland, OH 44135 USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-94396-0; 978-0-470-59468-1 J9 CERAM ENG SCI PROC PY 2010 VL 31 IS 3 BP 57 EP 65 PG 9 WC Materials Science, Ceramics; Materials Science, Coatings & Films; Materials Science, Composites SC Materials Science GA BBU92 UT WOS:000308296400005 ER PT S AU Weiss, CA Morefield, SW Malone, PG Henry, KS Harte, SP Koenigstein, ML AF Weiss, Charles A., Jr. Morefield, Sean W. Malone, Philip G. Henry, Karen S. Harte, Sean P. Koenigstein, Michael L. BE Zhu, D Lin, HT Mathur, S Ohji, T TI USE OF GLASS-CERAMIC COATINGS CONTAINING WATER-REACTIVE COMPONENTS AS A BONDING LAYER BETWEEN CONCRETE AND METAL SO ADVANCED CERAMIC COATINGS AND INTERFACES V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 34th International Conference and Exposition on Advanced Ceramics and Composites (ICACC)/Symposium on Advanced Ceramic Coatings for Structural, Environmental and Functional Applications CY JAN 24-29, 2010 CL Daytona Beach, FL SP Amer Ceram Soc (ACerS), Engn Ceram Div (ECD) AB Vitreous enamels that were designed to bond tightly to metals can be combined with high-melting-point water-reactive silicate-and aluminate-based ceramics to form a bonding layer between a reinforcing metal and an inorganic cement, such as portland or calcium aluminate cement. Vitreous enamels can bond to a variety of metal surfaces, and a variety of water-reactive ceramics also bond tightly to vitreous enamel. The bond strength from steel to enamel is on the order of 35 MPa. The tensile strength of concrete is typically 10% of the compressive strength. The steel-to-enamel bond is over eight times the tensile strength of structural concrete (compressive strength = 40 MPa). The elevated water content of concrete at the metal surface lowers the bond strength into the range of 2.2 to 2.7 MPa thereby making the interface the weakest bond. Pull-out tests were used to demonstrate that using bonding enamel could produce a 4-fold increase in bond strength and make the interfacial bond strength exceed the tensile strength of the concrete. Using a bonding enamel allows the tensile strength at the interface to match the ultimate tensile strength of the concrete. Tests conducted with composite beams demonstrated an increase in strength in experimental beams made with coated versus uncoated steel tubes was observed after 7 days of curing. In sample beams cured for 28 days, the ultimate loading on the coated beams was increased by over 30% on average. The bonding enamel interfaces allows us to take advantage of the new generation of very-high strength concretes in new concrete-steel composites. C1 [Weiss, Charles A., Jr.; Morefield, Sean W.; Malone, Philip G.] USAE Engn Res & Dev Ctr, Vicksburg, MS USA. [Malone, Philip G.; Harte, Sean P.] USAF Acad, Rolla, MO USA. [Koenigstein, Michael L.] Pro Perma Engineered Coatings, Rolla, MO USA. RP Weiss, CA (reprint author), USAE Engn Res & Dev Ctr, Vicksburg, MS USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-94396-0; 978-0-470-59468-1 J9 CERAM ENG SCI PROC PY 2010 VL 31 IS 3 BP 187 EP 192 PG 6 WC Materials Science, Ceramics; Materials Science, Coatings & Films; Materials Science, Composites SC Materials Science GA BBU92 UT WOS:000308296400016 ER PT S AU Roman, PE Dell, RF Velasquez, JD AF Roman, Pablo E. Dell, Robert F. Velasquez, Juan D. BE Velasquez, JD Jain, LC TI Advanced Techniques in Web Data Pre-processing and Cleaning SO ADVANCED TECHNIQUES IN WEB INTELLIGENCE - 1 SE Studies in Computational Intelligence LA English DT Article; Book Chapter ID SESSION RECONSTRUCTION; TEXT CATEGORIZATION; FRAMEWORK; RETRIEVAL; ALGORITHM; PROFILES; DYNAMICS; WEBSITE; SEARCH; FUTURE AB Central to successful e-business is the construction of web sites that attract users, capture user preferences, and entice them into making a purchase. Web mining is diverse data mining applied to categorize both the content and structure of web sites with the goal of aiding e-business. Web mining requires knowledge of the web site structure (hyperlink graph), the web content (vector model) and user sessions (the sequence of pages visited by each user to a site). Much of the data for web mining can be noisy. The origin of the noise comes from many sources, for example, undocumented changes to the web site structure and content, a different understanding of the text and media semantic, and web logs without individual user identification. There may not be any record of the number of times a specific page has been visited in a session as page is stored on a proxy or web browser cache. Such noise presents a challenge for web mining. This chapter presents issues with and approaches for cleaning web data in preparation for web mining analysis. C1 [Roman, Pablo E.; Velasquez, Juan D.] Univ Chile, Sch Sci & Engn, Dept Ind Engn, Web Intelligence Res Grp, Santiago, Chile. [Dell, Robert F.] USA, Postgrad Sch, Dept Operat Res, Monterey, CA USA. RP Roman, PE (reprint author), Univ Chile, Sch Sci & Engn, Dept Ind Engn, Web Intelligence Res Grp, Republ 701, Santiago, Chile. EM proman@ing.uchile.cl; dell@nps.edu; jvelasqu@dii.uchile.cl RI Roman, Pablo/G-1960-2011 OI Roman, Pablo/0000-0002-7105-9371 NR 110 TC 2 Z9 3 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1860-949X BN 978-3-642-14460-8 J9 STUD COMPUT INTELL PY 2010 VL 311 BP 19 EP 48 D2 10.1007/978-3-642-14461-5 PG 30 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BRA34 UT WOS:000282237500002 ER PT S AU Dobrogosz, WJ Peacock, TJ Hassan, HM AF Dobrogosz, Walter J. Peacock, Trent J. Hassan, Hosni M. BE Laskin, AI Sariaslani, S Gadd, GM TI Evolution of the Probiotic Concept: From Conception to Validation and Acceptance in Medical Science SO ADVANCES IN APPLIED MICROBIOLOGY, VOL 72 SE Advances in Applied Microbiology LA English DT Review; Book Chapter ID LACTIC-ACID BACTERIA; SUPEROXIDE-DISMUTASE GENE; LACTOBACILLUS-REUTERI ATCC-55730; PLACEBO-CONTROLLED TRIAL; ALANINE RACEMASE GENE; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; DENDRITIC CELLS; STREPTOCOCCUS-THERMOPHILUS; GASTROINTESTINAL-TRACT AB Two pioneering achievements by Ilya Ilyich Metchnikoff were recorded in 1908. Most notable was his Nobel Prize in Medicine for discovering the innate cellular immune response to an infectious challenge. Of lesser note was his recommendation, " ... to absorb large quantities of microbes, as a general belief is that microbes are harmful. This belief is erroneous. There are many useful microbes, amongst which the lactic bacilli have an honorable place." While his discovery of the inflammatory response was rapidly incorporated into our understanding of cellular immunity, his recommendation "to absorb large quantities of microbes," on the other hand, languished for decades in limbos of indifference, skepticism, and disbelief. The present chapter is a synopsis of salient discoveries made during the past 100 years, which gradually displaced these skepticisms, validated his concept of "useful microbes," and propelled his "lactic bacilli" into the mainstream of modern medical science, practice, and therapy. C1 [Dobrogosz, Walter J.; Hassan, Hosni M.] N Carolina State Univ, Dept Microbiol, Raleigh, NC 27695 USA. [Peacock, Trent J.] USA, Carl R Damall Med Ctr, Ft Hood, TX USA. RP Hassan, HM (reprint author), N Carolina State Univ, Dept Microbiol, Raleigh, NC 27695 USA. EM hosni_hassan@ncsu.edu NR 154 TC 12 Z9 15 U1 3 U2 11 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 0065-2164 BN 978-0-12-380989-6 J9 ADV APPL MICROBIOL JI Adv. Appl. Microbiol. PY 2010 VL 72 BP 1 EP 41 DI 10.1016/S0065-2164(10)72001-3 PG 41 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA BQD41 UT WOS:000280734700001 PM 20602986 ER PT B AU Stults, MD Ranade, R Li, VC Rushing, TS AF Stults, M. D. Ranade, R. Li, V. C. Rushing, T. S. BE VanZijl, GPAG Boshoff, WP TI Mechanical effects of rice husk ash in ultra-high performance concretes: A matrix study SO ADVANCES IN CEMENT-BASED MATERIALS LA English DT Proceedings Paper CT International Conference on Advanced Concrete Materials (ACM) CY NOV 17-19, 2009 CL Stellenbosch, SOUTH AFRICA SP Stellenbosch Univ, Concrete Soc So Africa ID STRENGTH; CEMENT AB Rice husk ash (RHA) has been observed to greatly improve both the mechanical and durability performance of conventional concrete mixtures, including increases in compressive strength while improving resistance to chloride ion transport and decreased permeability. This study explores the effects of using RHA as a mineral admixture in an ultra-high-performance concrete (UHPC) matrix, for which very high compressive strengths have already been achieved through dense particle packing and selection of materials. RHA is a promising material because of its widespread availability, its effectiveness as a pozzolanic material, and its potential for creating more environmentally sustainable building materials. Results of this study indicate that through the inclusion of RHA, the compressive strength of various mixtures at various water-binder ratios was improved and that RHA should be considered further for its use as a pozzolan in UHPC. C1 [Stults, M. D.; Ranade, R.; Li, V. C.] Univ Michigan, Adv Civil Engn Mat Res Lab, Ann Arbor, MI 48109 USA. [Rushing, T. S.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Stults, MD (reprint author), Univ Michigan, Adv Civil Engn Mat Res Lab, Ann Arbor, MI 48109 USA. RI Ranade, Ravi/I-6387-2013 OI Ranade, Ravi/0000-0001-6030-8371 NR 11 TC 0 Z9 0 U1 1 U2 4 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-203-85601-7; 978-0-415-87637-7 PY 2010 BP 19 EP 26 PG 8 WC Construction & Building Technology; Engineering, Mechanical; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA BC6IJ UT WOS:000353964900003 ER PT S AU LaSalvia, JC Leavy, RB Houskamp, JR Miller, HT MacKenzie, DE Campbell, J AF LaSalvia, J. C. Leavy, R. B. Houskamp, J. R. Miller, H. T. MacKenzie, D. E. Campbell, J. BE Swab, JJ TI BALLISTIC IMPACT DAMAGE OBSERVATIONS IN A HOT-PRESSED BORON CARBIDE SO ADVANCES IN CERAMIC ARMOR V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 33rd International Conference on Advanced Ceramics and Composites CY JAN 18-23, 2009 CL Daytona Beach, FL ID TUNGSTEN LONG RODS; SILICON-CARBIDE; INTERFACE DEFEAT; PENETRATION; TRANSITION; VELOCITIES; TARGETS; KM/S; COMPRESSION; PROJECTILES AB In an effort to better understand the connection between the inelastic deformation mechanisms in ceramics and their ballistic performance at a more fundamental level, observations of damage in a commercial hot-pressed boron carbide (B(4)C) impacted ballistically are reported. The ballistic targets consisted of B(4)C cylinders slip-fitted into titanium alloy (Ti6Al4V) cups and welded cover plates. This target configuration provided lateral confinement for the B(4)C cylinders but zero-lateral pre-stress. Targets were impacted with laboratory-scale tungsten-iron-nickel (93%W-Fe-Ni) long-rod penetrators between 800 m/s and 1600 m/s. In the limited number of ballistic experiments conducted, two apparent dwell/penetration transition velocities (1060 m/s and 1200 m/s) were observed. The B(4)C cylinder impacted near the upper dwell/penetration transition velocity was sectioned and polished to reveal sub-surface damage features. Both optical and scanning electron microscopy were utilized to examine the cross-section. The observed damage features are consistent with the low fracture toughness of this material. This suggests that the velocity range demarcated by the two apparent dwell/penetration transition velocities may actually be a wide transition zone due to stochastic variations in material and ballistic experiment parameters. The observed damage features are compared and contrasted with that previously reported for a commercial hot-pressed silicon carbide (SiC). C1 [LaSalvia, J. C.; Leavy, R. B.; Houskamp, J. R.; Miller, H. T.; MacKenzie, D. E.; Campbell, J.] USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP LaSalvia, JC (reprint author), USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. NR 26 TC 1 Z9 1 U1 1 U2 11 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-45755-9 J9 CERAM ENG SCI PROC PY 2010 VL 30 IS 5 BP 45 EP 55 PG 11 WC Materials Science, Ceramics SC Materials Science GA BQI71 UT WOS:000281126300005 ER PT S AU Miller, HT LaSalvia, JC Leavy, RB MacKenzie, DE AF Miller, H. T. LaSalvia, J. C. Leavy, R. B. MacKenzie, D. E. BE Swab, JJ TI CHARACTERIZATION OF MICROSTRUCTURAL DAMAGE IN SILICON CARBIDE PROCESSED VIA MODIFIED CHEMICAL VAPOR DEPOSITION SO ADVANCES IN CERAMIC ARMOR V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 33rd International Conference on Advanced Ceramics and Composites CY JAN 18-23, 2009 CL Daytona Beach, FL ID AMORPHIZATION AB The role of micro and macro inelastic deformation and damage mechanisms in the high velocity penetration resistance of many technical ceramics is not fully understood. By comparing and contrasting the damage mechanisms of similar ceramics impacted at high velocities, insight can be gained, qualitatively, into the influence of crystal structure and microstructure. In this study, two commercially-available silicon carbide (SiC) variants were impacted with cemented carbide spheres (WC-6wt.%Co) at velocities between 300 m/s and 1700 m/s. The two SiC variants were SiC-N (BAE Advanced Ceramics) and CVC SiC (TREX Enterprises). Ceramic tiles 76.2 mm in diameter and 19.05 mm thick were heavily confined and pre-stressed in a titanium alloy (Ti-6Al-4V) target fixture. Select impacted tiles (low and high impact velocities) were subsequently sectioned and polished. Optical and scanning electron microscopy were utilized to examine the sub-surface damage features. Radial, lateral, and cone cracking were common in both materials. In SiC-N, comminuted regions due predominately to microcracking (grain boundary) and some microcleavage (grains) were observed. In the CVC SiC, shear localization due to fragmentation (intersecting microcleavage) and solid-state amorphization were observed. Grain boundary microcracking appeared to suppress shear localization in SiC-N. C1 [Miller, H. T.; LaSalvia, J. C.; Leavy, R. B.; MacKenzie, D. E.] USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. RP Miller, HT (reprint author), USA, Res Lab, AMSRD ARL WM MD, Aberdeen Proving Ground, MD 21005 USA. NR 12 TC 0 Z9 0 U1 0 U2 3 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-45755-9 J9 CERAM ENG SCI PROC PY 2010 VL 30 IS 5 BP 57 EP 65 PG 9 WC Materials Science, Ceramics SC Materials Science GA BQI71 UT WOS:000281126300006 ER PT S AU Schmidt, KF Little, JR Ellingson, WA Green, W AF Schmidt, K. F., Jr. Little, J. R., Jr. Ellingson, W. A. Green, W. BE Swab, JJ TI A PORTABLE MICROWAVE INTERFERENCE SCANNING SYSTEM FOR NONDESTRUCTIVE TESTING OF MULTI-LAYERED DIELECTRIC MATERIALS SO ADVANCES IN CERAMIC ARMOR V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 33rd International Conference on Advanced Ceramics and Composites CY JAN 18-23, 2009 CL Daytona Beach, FL AB A portable nondestructive technique that can be used for in-situ monitoring of the condition of multilayer composite material ceramic armor has been developed and demonstrated using the Evisive Scan microwave interference scanning method. The portable microwave interference scanning system has been demonstrated to detect damage on test specimens and engineered features in surrogates. Work has been conducted using specially fabricated surrogates and as-produced and non-ballistic impact damaged specimens. The microwave interference scanning technique detects and images cracks, laminar features and variations in material properties such as density. It requires access to only one surface, and no coupling medium. Other methods, including through-transmission x-ray, and destructive examination are used to establish quantitative performance. It appears' that the method is suitable for in-theater health monitoring of composite ceramic armor and that damage level data are not affected by separation of outer lamination layers. Test panels used in this work were provided by the US Army Research Laboratory, Ballistics Testing Station through Argonne National Laboratory. This paper will describe the system and present current results. C1 [Schmidt, K. F., Jr.; Little, J. R., Jr.] Evisive Inc, Baton Rouge, LA 70808 USA. [Ellingson, W. A.] Argonne Natl Lab, Argonne, IL USA. [Green, W.] Army Res Lab, Aberdeen Proving Ground, MD USA. RP Schmidt, KF (reprint author), Evisive Inc, Baton Rouge, LA 70808 USA. FU US Army RDECOM ARL; US Army RDECOM TARDEC FX This work is supported by the US Army RDECOM ARL and US Army RDECOM TARDEC whose staffs insight and technical contribution is much apprcciated. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-45755-9 J9 CERAM ENG SCI PROC PY 2010 VL 30 IS 5 BP 123 EP + PG 2 WC Materials Science, Ceramics SC Materials Science GA BQI71 UT WOS:000281126300012 ER PT S AU Brennan, RE Green, WH Sands, JM AF Brennan, Raymond E. Green, William H. Sands, James M. BE Swab, JJ TI DESTRUCTIVE TESTING AND NONDESTRUCTIVE EVALUATION OF ALUMINA STRUCTURAL CERAMICS SO ADVANCES IN CERAMIC ARMOR V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 33rd International Conference on Advanced Ceramics and Composites CY JAN 18-23, 2009 CL Daytona Beach, FL ID LOW-VELOCITY IMPACT; DAMAGE; COMPOSITES; FAILURE; TILES AB A combination of destructive and nondestructive testing methods was utilized to evaluate the impact velocity and energy conditions that caused fracture in alumina structural ceramics. Incremental damage was produced in aluminum-backed Al(2)O(3) tiles using drop tower testing for low velocity impact with a high mass indenter. Under these test conditions, a damage threshold range was determined below which there was no impact damage and above which fracture occurred. The majority of damage in the fractured samples consisted of radial and cone cracking. The samples were nondestructively evaluated using digital radiography, x-ray computed tomography, and ultrasound C-scan imaging. Bulk damage detected by these techniques was compared to surface damage observed by visual inspection. Qualitative evaluation of surface and bulk cracks and quantitative percent damage assessment were used to compare the integrity of the nondestructive techniques. While all three methods were able to detect surface cracks, C-scan imaging was more effective at detecting internal damage in the alumina samples while x-ray computed tomography was more effective at producing three-dimensional images of the crack patterns. C1 [Brennan, Raymond E.; Green, William H.; Sands, James M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Brennan, RE (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. NR 20 TC 0 Z9 0 U1 1 U2 4 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-45755-9 J9 CERAM ENG SCI PROC PY 2010 VL 30 IS 5 BP 135 EP 146 PG 12 WC Materials Science, Ceramics SC Materials Science GA BQI71 UT WOS:000281126300013 ER PT S AU Green, WH Brennan, R Carter, RH AF Green, William H. Brennan, Raymond Carter, Robert H. BE Swab, JJ TI NONDESTRUCTIVE EVALUATION OF AS FABRICATED AND DAMAGED ENCAPSULATED CERAMICS SO ADVANCES IN CERAMIC ARMOR V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 33rd International Conference on Advanced Ceramics and Composites CY JAN 18-23, 2009 CL Daytona Beach, FL AB X-ray computed tomography (XCT) and ultrasonic testing (UT) are two major nondestructive evaluation (NDE) methods used to inspect a wide variety of materials and components. Current work in the area of NDE of materials at the Army Research Laboratory includes inspection and analysis of both individual ceramic targets and ceramic panels. A number of samples have been evaluated using both XCT and UT, including encapsulated panels. XCT and UT results from NDE studies of as fabricated and damaged encapsulated ceramic panels will be shown and discussed. The results from the two NDE methods will be compared and contrasted. C1 [Green, William H.; Brennan, Raymond; Carter, Robert H.] USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM MD, Aberdeen Proving Ground, MD USA. RP Green, WH (reprint author), USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM MD, Aberdeen Proving Ground, MD USA. NR 10 TC 0 Z9 0 U1 0 U2 1 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-45755-9 J9 CERAM ENG SCI PROC PY 2010 VL 30 IS 5 BP 147 EP 158 PG 12 WC Materials Science, Ceramics SC Materials Science GA BQI71 UT WOS:000281126300014 ER PT S AU Fountzoulas, CG Sands, JM Gilde, G Patel, PJ AF Fountzoulas, Costas G. Sands, James M. Gilde, Gary Patel, Parimal J. BE Swab, JJ TI NUMERICAL STUDY OF THE EFFECT OF SURFACE STRESSES OF TRANSPARENT CERAMICS OF LAMINATED TARGETS FOR MILITARY ARMOR APPLICATIONS SO ADVANCES IN CERAMIC ARMOR V SE Ceramic Engineering and Science Proceedings LA English DT Proceedings Paper CT 33rd International Conference on Advanced Ceramics and Composites CY JAN 18-23, 2009 CL Daytona Beach, FL DE armor; modeling; spinel; failure analysis; defects AB With the rapid advancement of the computer power and the recent advances in the numerical techniques and materials model have allowed the accurate simulation of the ballistic impact into multilayer transparent armor configurations. The development of next generation ceramics is a key to providing the enhanced protection and extended service performance for future U.S. military systems. A significant development program is underway to improve processing and reduce costs associated with magnesium aluminate spinet. Pre-stressing of the ceramic materials has been shown to improve its ballistic characteristics. The purpose of this effort is to apply the existing modeling took in advancing ceramic transparent armor materials to fielded applications. This paper reports on the effect of various compressive stress levels on the depth of penetration (DOP) in the polycarbonate of a spinel/polycarbonate laminate impacted by a projectile. The ballistic behavior of the pre-stressed spinel was studied by ANSYS/AUTODYN commercial software and the results will be discussed in detail. C1 [Fountzoulas, Costas G.; Sands, James M.; Gilde, Gary; Patel, Parimal J.] USA, Res Lab, Survivabil Mat Branch, AMSRD ARL WM MD, Aberdeen Proving Ground, MD USA. RP Fountzoulas, CG (reprint author), USA, Res Lab, Survivabil Mat Branch, AMSRD ARL WM MD, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD USA. NR 9 TC 0 Z9 0 U1 0 U2 5 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 0196-6219 BN 978-0-470-45755-9 J9 CERAM ENG SCI PROC PY 2010 VL 30 IS 5 BP 195 EP 203 PG 9 WC Materials Science, Ceramics SC Materials Science GA BQI71 UT WOS:000281126300018 ER PT J AU Kim, HW Oh, S Minotra, D McNeese, M Yen, J Hanratty, T Strater, L Cuevas, H Colombo, D AF Kim, Hyun-Woo Oh, Sooyoung Minotra, Dev McNeese, Michael Yen, John Hanratty, Timothy Strater, Laura Cuevas, Haydee Colombo, Daniel BE Kaber, D Boy, G TI Enhancing Situation Awareness with Visual Aids on Cognitively-inspired Agent Systems SO ADVANCES IN COGNITIVE ERGONOMICS SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE Decision aid; Situation awareness; Knowledge visualization; Decision Support; Cognitively-inspired agent AB This paper describes the strengths of two types of visual aids: VADS (Visualization of Agent Decision Space) and ADT (Agent Decision Table). The VADS is a newly developed visual aid that intuitively represents complicated target attributes in a graphical form, whereas the ADT shows such things in a traditional tabular form. The strengths of each visual aid have been obtained through the analysis of real-time situational awareness queries. Graphical icons expressing multiple attributes are useful in achieving overall situation awareness in most cases. However, there are cases where presentation by a simple text is better in recognition than that by a graphical notation. We discuss the recognition of the ethnic affiliation of crowds as an example at the end. C1 [Kim, Hyun-Woo; Oh, Sooyoung; Minotra, Dev; McNeese, Michael; Yen, John] Penn State Univ, University Pk, PA 16802 USA. [Hanratty, Timothy] USA, Res Lab, Aberdeen Proving Ground, MD USA. [Strater, Laura; Cuevas, Haydee; Colombo, Daniel] SA Technol Inc, Marietta, GA USA. RP Kim, HW (reprint author), Penn State Univ, University Pk, PA 16802 USA. NR 8 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3492-3 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2010 BP 560 EP 567 PG 8 WC Engineering, Industrial; Ergonomics SC Engineering GA BSY32 UT WOS:000286105400057 ER PT J AU Minotra, D Oh, S Kim, HW McNeese, M Yen, J Hanratty, T Strater, L Cuevas, H Colombo, D AF Minotra, Dev Oh, Sooyoung Kim, Hyun-Woo McNeese, Michael Yen, John Hanratty, Timothy Strater, Laura Cuevas, Haydee Colombo, Dan BE Kaber, D Boy, G TI Establishing Trust in Decision-Aiding: The Role of a Visualization of Agent Decision-Space in Improving Operator Engagement with Reduced Cognitive Load SO ADVANCES IN COGNITIVE ERGONOMICS SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE Decision-aids; Human-automation-interaction; Automation-transparency; Multi-dimensional scaling; Cognitive-load ID CONTRAST AB Decision recommendation systems relieve operators from high cognitive-load during stressful situations. However, automation over-trust can disengage complacent operators from the task leading to lower situation awareness and inability to intervene and override incorrect recommendations. Our recent research effort was focused on a visualization of agent decision-space to improve automation transparency and aid the operator's perception of the environment. We describe specific properties of the interface and their anticipated benefits such as improved situation-awareness and expectancy. The visualization is compared with an alternative static representation with an emphasis on how the visualization improves expectancy. An experiment was conducted with a command and control simulation environment to compare the two representations. The results of the experiment have been encouraging. Observed performance improvements in specific scenario conditions, are in accordance to anticipated benefits of the visualization. C1 [Minotra, Dev; Oh, Sooyoung; Kim, Hyun-Woo; McNeese, Michael; Yen, John] Penn State Univ, University Pk, PA 16802 USA. [Hanratty, Timothy] USA, Res Lab, Washington, DC USA. RP Minotra, D (reprint author), Penn State Univ, University Pk, PA 16802 USA. NR 11 TC 0 Z9 0 U1 2 U2 3 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3492-3 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2010 BP 568 EP 575 PG 8 WC Engineering, Industrial; Ergonomics SC Engineering GA BSY32 UT WOS:000286105400058 ER PT J AU Merlo, JL Hancock, PA AF Merlo, James L. Hancock, P. A. BE Kaber, D Boy, G TI Pre-Motor Response Time Benefits in Multi-Modal Displays SO ADVANCES IN COGNITIVE ERGONOMICS SE Advances in Human Factors and Ergonomics Series LA English DT Article; Book Chapter DE Visual Signaling; Tactile Signaling; Multi-Modal Advantage ID INFORMATION; VISION; TOUCH AB The present series of experiments tested the assimilation and efficacy of purpose-created tactile messages based on five common military arm and hand signals. We compared the response times and accuracy rates to these tactile representations against the comparable responses to equivalent visual representations of these same messages. Results indicated that there was a performance benefit for concurrent message presentations which showed superior response times and improved accuracy rates when compared to individual presentations in either modality. Such improvement was identified as being due largely to a reduction in pre-motor response time and these improvements occurred equally in a military and non-military population. Results were not contingent upon the gender of the participant. Potential reasons for this multi-modal facilitation are discussed. The novel techniques employed to measure pre-motor response inform computational neuroergonomic models for multi-modal advantages in dynamic signaling. On a practical level, these results confirm the utility of tactile messaging to augment visual messaging, especially in challenging and stressful environments where visual messaging may not always be feasible or effective. C1 [Merlo, James L.] US Mil Acad, West Point, NY 10996 USA. [Hancock, P. A.] Univ Cent Florida, Orlando, FL 32816 USA. RP Merlo, JL (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 17 TC 0 Z9 0 U1 1 U2 1 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4398-3492-3 J9 ADV HUM FACT ERG SER JI ADV. HUMAN FACT. ERG. SER PY 2010 BP 607 EP 616 PG 10 WC Engineering, Industrial; Ergonomics SC Engineering GA BSY32 UT WOS:000286105400062 ER PT S AU Zakikhani, M Harrelson, DW Tom, JG Kissane, JA Allis, MK Kolber, JE AF Zakikhani, M. Harrelson, D. W. Tom, J. G. Kissane, J. A. Allis, M. K. Kolber, J. E. BE Rahman, M Brebbia, CA TI Environmental impacts on coastal structures with a case evaluation of armor stone protection at Keweenaw Waterway, USA SO ADVANCES IN FLUID MECHANICS VIII SE WIT Transactions on Engineering Sciences LA English DT Proceedings Paper CT 8th International Conference on Advances in Fluid Mechanics CY SEP 15-17, 2010 CL Algave, PORTUGAL SP Wessex Inst Technol, WIT Transact Engn Sci Fluid Mech Book Series DE hydrodynamic forces; response of structures; fluid dynamics; armor stone durability; great lakes; numerical modeling; laboratory testing AB The evaluation of armor stone performance as a viable construction material is essential to increasing the longevity of maritime structures used to protect harbors, coastal areas and navigable waterways from damaging waves and other forces. The environmental parameters have led to the armor stones deteriorating faster than laboratory testing indicates. This paper provides an overview of the decomposition of the four rock types (limestone, granite, quartzite, and concrete) over the five field inspections. The meteorological variables were used to calculate the number of freeze-thaw events that occurred over the time period. The water wave height data were used to calculate stone deterioration from wave actions. The results from the field observations, together with the meteorological analysis, were used to help better parameterize the numerical model and assist in identifying problems in scalability from laboratory test samples to field samples. C1 [Zakikhani, M.; Harrelson, D. W.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Kissane, J. A.] US Army Corps Engineers, Chicago, IL USA. [Allis, M. K.] US Army Corps Engineers, Detroit, MI USA. [Kolber, J. E.] US Army Corps Engineers, Buffalo, NY USA. RP Zakikhani, M (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU WIT PRESS PI SOUTHAMPTON PA ASHURST LODGE, SOUTHAMPTON SO40 7AA, ASHURST, ENGLAND SN 1746-4471 BN 978-1-84564-476-5 J9 WIT TRANS ENG SCI PY 2010 BP 417 EP 426 DI 10.2495/AFM100361 PG 10 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA BG9YF UT WOS:000394191500036 ER PT B AU Barfuss, SL Rahmeyer, WJ Cox, NC AF Barfuss, Steven L. Rahmeyer, William J. Cox, Nathan C. BE Li, Y Wu, S TI Eliminating Vortices at the Proposed Folsom Dam Auxiliary Spillway SO ADVANCES IN HYDRAULIC PHYSICAL MODELING AND FIELD INVESTMENT AND INVESTIGATION LA English DT Proceedings Paper CT International Symposium on Hydraulic Physical Modeling and Field Investigation (ISHPF 2010) CY SEP 13-15, 2010 CL Nanjing, PEOPLES R CHINA SP Nanjing Hydraul Res Inst, Int Assoc Hydro Environm Engn & Res, Chinese Hydraul Engn Soc, China Soc Hydropower Engn, Minist Water Resources China, Key Lab Water Sci & Engn, Minist Transport China, Key Lab Navigat Structures, State Key Lab Hydrol Water Resources & Hydraul Engn, Hohai Univ, China Inst Water Resources & Hydropower Res, Yangtze River Sci Res Inst, Inst Yellow River Hydraul Res, Chinese Soc Hydropower Engn, Navigat Engn Comm, Estuarine & Coastal Sci Res Ctr DE physical model Study; vortices; submerged radial gates; spillway capacity; flood passage AB Folsom Dam is on the American River about 20 miles northeast of Sacramento, California. The dam was designed and built by the U. S. Army Corps of Engineers (USACE) and transferred to Reclamation for operation and maintenance in 1956. The dam is a concrete gravity structure 340 ft high and impounds a reservoir of a little more than one million acre-ft. An auxiliary spillway has been proposed that will enhance flood reduction capabilities of the dam. The auxiliary spillway and gate structure will be located in a side channel near the left abutment of the existing spillway. A physical model study of the proposed auxiliary spillway structure at Utah State University revealed that the original proposed design was susceptible to strong surface vortices that were deemed unacceptable. After several unsuccessful attempts to reduce the strength of the vortices, a successful configuration was eventually determined by inclining the upstream head wall (vertical face wall) across the top of the gate structure into the flow at an incline of 20 degrees. This paper focuses on the design changes made at the spillway gate structure to reduce surface vortices resulting from the high velocity approach flow in the approach channel to the auxiliary spillway. Additionally, this paper discusses the potential vortex problems that are associated with submerged radial gate structures located in reservoir approach channels with higher approach velocities in comparison to those seen with typical submerged gates in a reservoir. The iterative process used during the model study to find an acceptable solution and to implement the working model configuration into the final USACE design is also reviewed. C1 [Barfuss, Steven L.; Rahmeyer, William J.] Utah State Univ, Coll Engn, Logan, UT 84322 USA. [Cox, Nathan C.] US Army Corps Engineers, Sacramento, CA 95814 USA. RP Barfuss, SL (reprint author), Utah State Univ, Coll Engn, Logan, UT 84322 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU CHINA WATERPOWER PRESS-CWPP PI BEIJING PA 6 SANLIHELU, FUXINGMENWAI, BEIJING, 100044, PEOPLES R CHINA BN 978-7-5084-8554-6 PY 2010 BP 413 EP 420 PG 8 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA BG7XK UT WOS:000391896700068 ER PT J AU Sloan, SD Peterie, SL Ivanov, J Miller, RD McKenna, JR AF Sloan, Steven D. Peterie, Shelby L. Ivanov, Julian Miller, Richard D. McKenna, Jason R. BE Miller, RD Holliger, K Bradford, JH TI Void Detection Using Near-surface Seismic Methods SO ADVANCES IN NEAR-SURFACE SEISMOLOGY AND GROUND-PENETRATING RADAR SE Geophysical Developments Series LA English DT Proceedings Paper CT Workshop on Advances in Near-Surface Seismology and Ground-Penetrating Radar held during the SEG Annual Meeting CY OCT 25-30, 2009 CL Houston, TX SP SEG ID REFLECTION DATA; VELOCITY; STRESS; WAVES; SANDSTONES AB Detection of anomalies such as voids in the shallow subsurface using noninvasive geophysical techniques has proved to be challenging at best. Three near-surface seismic methods are introduced, including diffracted body waves, backscattered surface waves, and changes in reflection moveout velocities to detect voids directly or their effects on surrounding material properties using different parts of the wavefield. Examples are presented, including modeled and field data sets to demonstrate each technique. Body-wave diffractions were used to identify and locate man-made tunnels in multiple geologic settings. Variations in shear-wave reflection velocities are shown to correlate to changes in stress over known void locations; backscattered surface waves are shown to correlate with a known void location. Results of the studies show that the field data correlate well with the synthetic, and these methods show promise in furthering the ability to locate subsurface voids and their effects on the surrounding media. C1 [Sloan, Steven D.; McKenna, Jason R.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39183 USA. [Peterie, Shelby L.; Ivanov, Julian; Miller, Richard D.] Kansas Geol Survey, Lawrence, KS 66044 USA. RP Sloan, SD (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39183 USA. NR 37 TC 4 Z9 4 U1 1 U2 7 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA PO BOX 702740, TULSA, OK 74170 USA BN 978-1-56080-224-2 J9 GEOPHYS DEV SER PY 2010 VL 15 BP 201 EP 218 DI 10.1190/1.9781560802259.ch12 PG 18 WC Geochemistry & Geophysics; Oceanography SC Geochemistry & Geophysics; Oceanography GA BC3UQ UT WOS:000352001900013 ER PT J AU Ivanov, J Miller, RD Xia, JH Dunbar, JB Peterie, S AF Ivanov, Julian Miller, Richard D. Xia, Jianghai Dunbar, Joseph B. Peterie, Shelby BE Miller, RD Holliger, K Bradford, JH TI Refraction Nonuniqueness Studies at Levee Sites Using the Refraction-tomography and JARS Methods SO ADVANCES IN NEAR-SURFACE SEISMOLOGY AND GROUND-PENETRATING RADAR SE Geophysical Developments Series LA English DT Proceedings Paper CT Workshop on Advances in Near-Surface Seismology and Ground-Penetrating Radar held during the SEG Annual Meeting CY OCT 25-30, 2009 CL Houston, TX SP SEG ID TRAVEL-TIME TOMOGRAPHY; SURFACE-WAVES; CURVES AB The utility of two varied approaches to first-arrival time analysis of seismic data acquired at several unique levee sites is demonstrated by solving the inverse refraction-traveltime problem (IRTP). These data were evaluated using conventional refraction tomography and joint analysis of refractions with surface waves (JARS). The JARS approach uses a reference model, derived from surface-wave-calculated shear-wave velocity estimates, as a constraint in reducing refraction nonuniqueness. At those levee sites, conventional refraction-tomography and JARS methods provided different solutions, equally matching the observed data. This observation suggests both approaches are equally possible from a numerical perspective. The JARS images reveal horizontal layering patterns, laterally uniform velocity trends, mild velocity variations, and channel-like features consistent with geologic expectations. In addition, the JARS approach demonstrated the capability for imaging low-velocity layers/zones, something not seen using conventional refraction or refraction-tomography techniques. As a result of these qualitative observations, without ground truth to support an earth model (e.g., from wells), the JARS approach can be viewed as an additional method for finding solutions to the IRTP. However, from all evidence in those studies, the JARS approach represents a possible solution and an example of the potential adverse affect of nonuniqueness. These empirical results support the understanding that for a given refraction data set, significantly different and equally possible velocity-model solutions can exist, resolving which is truly best using invasive ground truth. C1 [Ivanov, Julian; Miller, Richard D.; Xia, Jianghai; Peterie, Shelby] Kansas Geol Survey, Lawrence, KS 66044 USA. [Dunbar, Joseph B.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA. RP Ivanov, J (reprint author), Kansas Geol Survey, Lawrence, KS 66044 USA. NR 21 TC 1 Z9 1 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA PO BOX 702740, TULSA, OK 74170 USA BN 978-1-56080-224-2 J9 GEOPHYS DEV SER PY 2010 VL 15 BP 327 EP 335 DI 10.1190/1.9781560802259.ch20 PG 9 WC Geochemistry & Geophysics; Oceanography SC Geochemistry & Geophysics; Oceanography GA BC3UQ UT WOS:000352001900021 ER PT S AU Malone, P Morefield, SW Weiss, CA Baugher, E AF Malone, Philip Morefield, Sean W. Weiss, Charles A. Baugher, Earl BE Baldwin, C Evele, H Pershinsky, R TI PROGRESS IN THE USE OF SPECIALIZED ENAMEL COATINGS TO BOND CONCRETE TO STEEL SO ADVANCES IN PORCELAIN ENAMEL TECHNOLOGY SE Ceramic Transactions LA English DT Proceedings Paper CT 70th Porcelain-Enamel-Institute Technical Forum CY JUN 09-12, 2008 CL Nashville, TN SP Amer Ceram Soc, Porcelain Enamel Inst C1 [Malone, Philip] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Baugher, Earl] Porcelain Enamel Inst, Vicksburg, MS USA. RP Malone, P (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 1042-1122 BN 978-0-470-40841-4 J9 CERAM TRANS PY 2010 VL 211 BP 45 EP + PG 2 WC Materials Science, Ceramics SC Materials Science GA BTL80 UT WOS:000287226300009 ER PT S AU Mosurkal, R Tucci, V Samuelson, LA Smith, KD Westmoreland, PR Parmar, VS Kumar, J Watterson, AC AF Mosurkal, Ravi Tucci, Vincent Samuelson, Lynne A. Smith, Kenneth D. Westmoreland, Phillip R. Parmar, Virinder S. Kumar, Jayant Watterson, Arthur C. BE Clarson, SJ Owen, MJ Smith, SD VanDyke, ME TI Novel Organo-Siloxane Copolymers for Flame Retardant Applications SO ADVANCES IN SILICONES AND SILICONE-MODIFIED MATERIALS SE ACS Symposium Series LA English DT Proceedings Paper CT 4th Silicones and Silicone-Modified Materials Symposium CY SEP 10-14, 2006 CL San Francisco, CA SP Amer Chem Soc, Div Polymer Chem Inc, Proctor & Gamble, Amer Chem Soc AB Environmentally safe polysiloxane copolymers, such as copolyamides, copolyesters and copolyimides with aromatic linkers were biocatalytically synthesized using lipase as a bio-catalyst. Their thermal and flame-retardant properties were investigated. Polysiloxane copolyamides show excellent flame-retardant properties in terms of heat release capacities and char yields. The crosslinked copolyamides further improved the heat release capacity to as low as 90 J/g-K. However, the degradation temperatures are relatively low compared to copolyimides synthesized enzymatically and non-enzymatically. The copolyimides synthesized using various dianhydride monomers without using any biocatalyst showed improved degradation temperatures of up to 440-470 degrees C compared to copolyamides/esters (390 - 410 degrees C). C1 [Mosurkal, Ravi; Samuelson, Lynne A.] USA, Natick Soldier RDEC, Natick, MA 01760 USA. RP Mosurkal, R (reprint author), USA, Natick Soldier RDEC, Natick, MA 01760 USA. EM Arthur_Watterson@uml.edu RI MOSURKAL, RAVI/P-6981-2015 NR 11 TC 5 Z9 5 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 SIXTEENTH ST NW, WASHINGTON, DC 20036 USA SN 0097-6156 BN 978-0-8412-2559-6 J9 ACS SYM SER JI ACS Symp. Ser. PY 2010 VL 1051 BP 157 EP 165 DI 10.1021/bk-2010-1051.ch013 PG 9 WC Polymer Science SC Polymer Science GA BAQ72 UT WOS:000305197500013 ER PT S AU Rohith, MV Somanath, G Kambhamettu, C Geiger, C Finnegan, D AF Rohith, M., V Somanath, Gowri Kambhamettu, Chandra Geiger, Cathleen Finnegan, David BE Bebis, G Boyle, R Parvin, B Koracin, D Chung, R Hammound, R Hussain, M Han, TK Crawfis, R Thalmann, D Kao, D Avila, L TI Modified Region Growing for Stereo of Slant and Textureless Surfaces SO ADVANCES IN VISUAL COMPUTING, PT I SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 6th International Symposium on Visual Computing CY NOV 29-DEC 01, 2010 CL Las Vegas, NV SP UNR, DRI, LBNL, NASA Ames, Air Force Res Lab, Intel, DigitalPersona, Equinox, Ford, Hewlett Packard, Mitsubishi Elect Res Lab, iCore, Toyota, Delphi, Gen Elect, Microsoft MSDN, Volt ID IMAGES AB In this paper, we present an algorithm for estimating disparity for images containing large textureless regions. We propose a fast and efficient region growing algorithm for estimating the stereo disparity. Though we present results on ice images, the algorithm can be easily used for other applications. We modify the first-best region growing algorithm using relaxed uniqueness constraints and matching for sub-pixel values and slant surfaces. We provide an efficient method for matching multiple windows using a linear transform. We estimate the parameters required by the algorithm automatically based on initial correspondences. Our method was tested on synthetic, benchmark and real outdoor data. We quantitatively demonstrated that our method performs well in all three cases. C1 [Rohith, M., V; Somanath, Gowri; Kambhamettu, Chandra] Univ Delaware, Dept Comp & Informat Sci, Video Image Modeling & Synth VIMS Lab, Newark, DE 19716 USA. [Geiger, Cathleen] Univ Delaware, Dept Geog, Newark, DE USA. [Finnegan, David] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Rohith, MV (reprint author), Univ Delaware, Dept Comp & Informat Sci, Video Image Modeling & Synth VIMS Lab, Newark, DE 19716 USA. FU National Science Foundation (NSF) Office of Polar Program [ANT0636726, ARC0612105] FX This work was made possible by National Science Foundation (NSF) Office of Polar Program grants, ANT0636726 and ARC0612105. NR 16 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-17288-5 J9 LECT NOTES COMPUT SC PY 2010 VL 6453 BP 666 EP + PG 3 WC Computer Science, Artificial Intelligence; Computer Science, Theory & Methods SC Computer Science GA BUW97 UT WOS:000290548000064 ER PT B AU Montgomery, SP Blackbourne, L AF Montgomery, Sean P. Blackbourne, Lorne BE Sen, CK TI In-Theater Wound Care SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID DAMAGE CONTROL RESUSCITATION; OPERATION-IRAQI-FREEDOM; HEMORRHAGE CONTROL; TOURNIQUET USE; COMBAT OPERATIONS; UNITED-STATES; GROIN INJURY; LETHAL MODEL; CASE SERIES; SURVIVAL AB Background: There are many differences between combat and noncombat wounds, both in mechanisms and the initial treatment of the wounds. Additionally, the current conflicts in Iraq and Afghanistan have allowed the introduction of cutting edge products and techniques into the battlefield. The Problem: War wounds are often dirty and high energy. This is especially true in the current conflicts, where improvised explosive devices have accounted for the majority of all combat wounds. Additionally, the initial first aid and medical care is delivered in an austere and limited resource environment. Basic/Clinical Science Advances: The current wars have seen the widespread use of advanced hemostatic dressings for initial wound care. Tourniquets have also made a resurgence and will need to be accounted for in all future research on wound care. In the hospital setting, the concept of damage control resuscitation has been widely implemented, with the early use of fresh frozen plasma, platelets, and fresh whole blood becoming common. Clinical Care Relevance: The advances in military combat wound care are already being transferred to the civilian setting. Specifically, the topical hemostatic agents pioneered in soldiers are becoming widespread among civilians, and increasing ratios of plasma to blood have been widely adapted in civilian trauma centers. Conclusion: Advances in wound care in the theater of war have centered around achieving rapid local hemostasis with tourniquets and hemostatic agents. C1 [Montgomery, Sean P.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Blackbourne, Lorne] USA, Inst Surg Res, Dept Surg, San Antonio, TX USA. RP Montgomery, SP (reprint author), Walter Reed Army Med Ctr, Dept Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM sean.p.montgomery@us.army.mil NR 24 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 19 EP 23 DI 10.1089/awc.2009.0065 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600005 ER PT B AU Petersen, K Hospenthal, D Wortmann, G AF Petersen, Kyle Hospenthal, Duane Wortmann, Glenn BE Sen, CK TI Update on Bioburden Control and Treatment of War Wound Infections SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID TOPICAL ANTIMICROBIAL AGENTS; DIABETIC FOOT ULCERS; NEGATIVE-PRESSURE; IN-VITRO; THERAPY; INJURIES; TRIAL; COMPLICATIONS; IRRIGATION; MANAGEMENT AB Background: Combat injury related wounds are generally acute, and occur in young, otherwise healthy adults. The most significant sequelae of wound bioburden, sepsis, which previously affected 90% of casualties in the pre-antibiotic era, continues to occur in 5-10%, causing considerable morbidity and some mortality. Controlling or eradicating bioburden before the critical colonization stage of 105 colony forming unit/g or more than four bacterial species might decrease infectious sequelae. The Problem: Modern combat wounds are complex, usually blast-related injuries, with extensive soft tissue damage, which is often complicated by vascular impairment and underlying bone injury. Persons developing infection may be critically ill, have received multiple transfusions, and suffer multi-organ impairment. With modern debridement and posttrauma antibiotic use, combat wound pathogens have changed from Clostridia and Streptococcus to multidrug-resistant nosocomial pathogens such as Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii. New modalities that prevent the selection of drug-resistant bacteria, and prevent wound-related sepsis and death are needed. Basic/Clinical Science Advances: in 2008 numerous approaches to bioburden reduction were published. Several having potential for combat wound care include novel diagnostics, dressings, negative pressure devices, topical solutions, antimicrobial peptides, and innovative approaches to surgical care. Clinical Care Relevance: Application of some of these aforementioned novel approaches might reduce multidrug-resistant bacterial colonization and wound infection, but more study is required. Conclusion: Limited studies were done on combat-related bioburden reduction in 2008. Work focused on chronic wound infections may have potential crossover utility in combat wounds; however, more studies are needed in this unique population. C1 [Petersen, Kyle] USN, Med Res Ctr, Undersea Med Div, Silver Spring, MD 20910 USA. [Hospenthal, Duane] San Antonio Mil Med Ctr, Infect Dis Serv, Ft Sam Houston, TX USA. [Wortmann, Glenn] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. RP Petersen, K (reprint author), USN, Med Res Ctr, Undersea Med Div, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kyle.petersen@med.navy.mil NR 34 TC 0 Z9 0 U1 1 U2 2 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 24 EP 30 DI 10.1089/awc.2009.0058 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600006 ER PT B AU Steele, SR Peoples, GE AF Steele, Scott R. Peoples, George E. BE Sen, CK TI Damage Control in the War Wounded SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID CONTROL RESUSCITATION; CONTROL SURGERY; OPEN ABDOMEN; CONTROL LAPAROTOMY; EARLY COAGULOPATHY; CONTROL PRINCIPLES; COMBAT CASUALTIES; FASCIAL CLOSURE; TRAUMA; MANAGEMENT AB Background: Present-day wartime conflicts have highlighted the controversy regarding the optimal treatment for combat casualties. One such component, damage control surgery (DCS), has made it into mainstream practice for the most severely injured patients, and brought improved survival to injuries that previously resulted in death. The Problem: Despite system and technological improvements in combat casualty care, continued efforts are needed to reduce morbidity and mortality. DCS has emerged as a leading effort. This article describes its role on the modern-day battlefield and highlights the impact on contemporary military medicine. Basic/Clinical Science Advances: Evidence has demonstrated the high mortality associated with the commencement of an irreversible physiological insult connected with the "lethal triad" of hypothermia, acidosis, and coagulopathy. DCS attempts to halt this process through an abbreviated initial surgery aimed at controlling hemorrhage and preventing further contamination. Subsequently, the patient is rewarmed and metabolic derangements are corrected before returning for definitive surgical care. Clinical Care Relevance: While DCS is widely practiced in the civilian arena, its routine use in the combat wounded has been implemented during recent conflicts, and represents one of the major surgical shifts to improve outcomes and reduce mortality. Conclusion: Caring for combat injured provides unique challenges to surgeons due to multiple influences, including austere conditions, limited resources, and worldwide evacuation requirements. Yet, the implementation of DCS principles has had a significant impact on providing state of the art care, and improved outcomes for those wounded in battle. C1 [Steele, Scott R.] Madigan Army Med Ctr, Dept Surg, Ft Lewis, WA 98513 USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA. RP Steele, SR (reprint author), Madigan Army Med Ctr, Dept Surg, 9606 Piperhill Dr SE, Ft Lewis, WA 98513 USA. EM harkersteele@gmail.com NR 34 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 31 EP 37 DI 10.1089/awc.2009.0015 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600007 ER PT B AU Vertrees, A Shriver, C AF Vertrees, Amy Shriver, Craig BE Sen, CK TI Management of the Open Abdominal Wound SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID ACELLULAR DERMAL MATRIX; PLANNED VENTRAL HERNIA; OPEN ABDOMEN; FASCIAL CLOSURE; DAMAGE CONTROL; REPAIR AB Background: Loss of abdominal domain is common in trauma and sepsis due to generalized edema. Leaving the abdominal fascia open prevents abdominal compartment syndrome, but it creates another problem with associated morbidity and mortality. The Problem: Intraabdominal contents are contained within a myofascial sleeve. After laparotomy, intraabdominal contents may not be able to be replaced into the abdomen resulting in an open abdomen. Management of the open abdomen must address potential for evaporative losses, contamination, and reversal of causative factors. Retraction of fascial edges and granulation tissue forming a "visceral block" may preclude eventual closure. Avoiding complications including enterocutaneous fistula, prolonged, or recurrent hospitalizations, and recurrence of hernia are other important aspects of open abdominal management. Basic/Clinical Science Advances: Open abdomen management has progressed from simple and inexpensive containment of abdominal contents with Bogota bag closure to more costly negative pressure closure systems and use of mesh. Numerous methods of closure have been described with eventual fascial closure ranging from 25% to 100%. Clinical Care Relevance: Ideal management of the open abdomen must consider several aspects of patient care. Minimizing or reversing factors causing intraabdominal hypertension include judicious fluid administration, optimization of ventilator settings, adequate hemostasis, and control of sepsis. Providing tension to fascial edges prevents retraction, although excessive tension may devitalize fascial edges. Recurrence of hernia occurs with closing under suboptimal circumstances or using a material that would fail long term. Conclusion: Open abdomen management continues to evolve. Primary fascial closure with minimal complications is ideal. Temporary closures allow time for reversal of causative factors and increase the probability of primary fascial closure. Techniques providing tension to fascia increase the probability of closure. Supplemental closure devices vary in cost, effectiveness, and complications. There is currently no consensus regarding the ideal method that would allow a high rate of closure and minimize complications. C1 [Vertrees, Amy; Shriver, Craig] Walter Reed Army Med Ctr, Gen Surg Serv, Washington, DC 20307 USA. RP Vertrees, A (reprint author), Walter Reed Army Med Ctr, Gen Surg Serv, Bldg 2,5th Floor,6900 Georgia Ave NW, Washington, DC 20307 USA. EM amy.vertrees@us.army.mil NR 23 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 38 EP 43 DI 10.1089/awc.2009.0027 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600008 ER PT B AU Andersen, RC Shawen, SB Keeling, JJ O'Toole, RV AF Andersen, Romney C. Shawen, Scott B. Keeling, John J. O'Toole, Robert V. BE Sen, CK TI The Mangled Extremity SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID TIBIAL FRACTURES; AMPUTATION; CELLS; RECONSTRUCTION; TRAUMA; TISSUE; MANAGEMENT; INJURIES; OUTCOMES; DEFECTS AB Background: The global war on terror has produced devastating mangled extremities. Choosing whether or not to salvage the limb is a difficult decision for the surgeon and the patient. The Problem: There are no definitive studies that demonstrate which limbs would benefit from limb salvage and which ones would be best treated with an early amputation. Attempts at reconstruction involve replacing lost skin, bone, muscle, nerve tissue, and vasculature. Reconstructed extremities often are complicated by limited function and chronic pain, while amputation requires life-long prosthetic care. Basic/Clinical Science Advances: Stem cell research affords the potential to regenerate some of the lost tissues. Clinical studies like the Military Extremity Trauma and Amputation/Limb Salvage (METALS) study will potentially help better define which patients would benefit from limb salvage and which would benefit from early amputation. Clinical Care Relevance: If the Military Extremity Trauma and Amputation/Limb Salvage study is able to demonstrate groups of patients who would benefit with one type of treatment over another it would afford the surgeon the ability to better counsel their patients on whether they recommend limb salvage or amputation. However, the study is retrospective in nature, and there will be difficulties in stratifying injuries. Conclusion: Currently, there are no clear indicators as to which patients would benefit from limb salvage or amputation. Surgeons must rely on their clinical judgment, taking into account the patients' desired goals to make recommendations on the advantages and disadvantages of different surgical treatments. C1 [Andersen, Romney C.; Shawen, Scott B.; Keeling, John J.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Washington, DC 20307 USA. [Andersen, Romney C.; Shawen, Scott B.; Keeling, John J.] Natl Naval Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, Bethesda, MD USA. [Andersen, Romney C.; O'Toole, Robert V.] Univ Maryland Med Syst, R Adams Cowley Shock Trauma Ctr, Div Orthopaed Traumatol, Baltimore, MD USA. [Andersen, Romney C.; Shawen, Scott B.; Keeling, John J.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. RP Andersen, RC (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Orthopaed Surg Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM romney.andersen@us.army.mil NR 26 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 53 EP 58 DI 10.1089/awc.2009.0026 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600010 ER PT B AU Fitzpatrick, KF Pasquina, PF Scoville, C AF Fitzpatrick, Kevin F. Pasquina, Paul F. Scoville, Charles BE Sen, CK TI Advances in Amputee Care SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID PROSTHESIS CONTROL; REINNERVATION AB Background: Recent military conflicts have resulted in a relatively high number of young, previously healthy traumatic amputees. This has provided the setting to explore recent advances in the field of amputee care. The Problem: Major limb amputation results in a significant loss of functional abilities. It is the responsibility of the rehabilitation team to maximize the postamputation function of these patients by providing a comprehensive approach to rehabilitation. This requires the integration of a multidisciplinary team. Basic/Clinical Science Advances: Recent advances in several fields have the potential to change functional outcomes in traumatic amputees. The development of interdisciplinary centers in which comprehensive amputee care can be performed provides an efficient model for the delivery of care. The utilization of a sports medicine model of physical therapy is a recent development that may improve the method in which rehabilitation is performed. Finally, surgical advances include targeted reinnervation to improve the control of an upper limb prosthesis and osseointegration to improve the limb/prosthesis interface. Advances in the design of prostheses, such as microprocessor-controlled knees and externally powered knees, have shown promise in improving the functional abilities of amputees. Clinical Care Relevance: These advances may prove to be beneficial and improve functional outcome in the full spectrum of amputee patients. Conclusion: Ongoing developments in amputee care provide continuing improvement to the rehabilitation and functional outcomes of amputees. C1 [Fitzpatrick, Kevin F.; Pasquina, Paul F.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Scoville, Charles] Walter Reed Army Med Ctr, Amputee Care Program, Washington, DC 20307 USA. [Pasquina, Paul F.] Natl Naval Med Ctr, Bethesda, MD USA. RP Fitzpatrick, KF (reprint author), Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, 6900 Georgia Ave, Washington, DC 20307 USA. EM kevin.f.fitzpatrick@us.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 59 EP 64 DI 10.1089/awc.2009.0023 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600011 ER PT B AU Kumar, AR Harshbarger, R Martin, B AF Kumar, Anand R. Harshbarger, Raymond Martin, Barry BE Sen, CK TI Plastic Surgery Challenges in War Wounded SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID OPEN TIBIAL FRACTURES; SOFT-TISSUE RECONSTRUCTION; LOWER-EXTREMITY; MICROSURGICAL RECONSTRUCTION; CRANIOPLASTY; FLAPS; MUSCLE; MANAGEMENT; COVERAGE; TRAUMA AB Background: Military treatment facilities continue to treat injured personnel supporting the Global War on Terrorism. Optimal reconstruction of massive soft tissue and bone defects of the extremities and craniofacial skeleton secondary to high-energy wounding mechanisms remain poorly characterized. The Problem: The ideal method to care for these injuries has continued to evolve and has yet to be completely defined. Effects of high-energy blast trauma on tissues, and the unusual bacteria (Acinetobacter baumanii) existing within the wounds, characterize these unique military wounds. Despite the relatively quick triage time, definitive care is delayed, and multiple concomitant injuries exist per patient. Basic/Clinical Science Advances: In addition to practicing established concepts from prior military conflicts, new technology for the advancement of trauma care has been applied. Treatment with novel flap reconstructions, distraction osteogenesis, bone grafting, and bone-engineering techniques including use of bone morphogenetic protein-2 has led to improved outcomes. Clinical Care Relevance: Modern battlefield care in conjunction with treatment protocols at continental United States Military Treatment Facilities has resulted in improved limb and craniofacial reconstruction. Conclusion: Successful limb salvage and craniofacial reconstruction can be accomplished in the subacute period using treatment protocols, which incorporate the use of novel flaps, fixation devices, and bone-engineering techniques. C1 [Kumar, Anand R.] Natl Naval Med Ctr, Dept Plast & Reconstruct Surg, Bethesda, MD 20889 USA. [Kumar, Anand R.; Harshbarger, Raymond; Martin, Barry] Uniformed Serv Univ Hlth Sci, Dept Surg Plast Surg, Bethesda, MD 20814 USA. [Harshbarger, Raymond; Martin, Barry] Walter Reed Army Med Ctr, Dept Plast & Reconstruct Surg, Washington, DC 20307 USA. RP Kumar, AR (reprint author), Natl Naval Med Ctr, Dept Plast & Reconstruct Surg, 8901 Wisconsin Ave, Bethesda, MD 20889 USA. EM arkumar@mac.com NR 25 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 65 EP 69 DI 10.1089/awc.2009.0087 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600012 ER PT B AU Littlefield, P Cote, C Coppit, G AF Littlefield, Phillip Cote, Christopher Coppit, George BE Sen, CK TI The Use of Three-Dimensional Models in the Treatment of Craniomaxillofacial Injuries SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID AFGHANISTAN; CASUALTIES; FREEDOM; HEAD AB Background: The use of explosive weaponry and high-powered ordnance in modern combat has resulted in increasingly complex patterns of craniomaxillofacial injures. These injuries include high-velocity penetrating injuries, relatively low-velocity penetrating injuries, burns, and over pressurization blast effect injuries. These injuries typically involve extensive loss of and injury to soft tissue, dentition, ocular, bony, and neurovascular structures. Reestablishment of proper function and cosmesis in these patients presents special challenges to the reconstructive surgeon. We have found that scale three-dimensional (3D) models generated from fine-cut computed tomography scans of the defect are useful in preoperative counseling, planning and rehearsing the operative procedure, reducing operative times, and improving outcomes. The Problem: Massive traumatic head and neck injuries present special challenges to the reconstructive surgeon. Significant functional (speech, swallowing, and visual) and cosmetic defects can occur, making rehabilitation of these patients difficult. The balance between form and function in the reconstruction of these patients is facilitated by the use of preoperative 3D scanning. Basic/Clinical Science Advances: Advances in imaging techniques (3D modeling) allow for more precise interpretation of the traumatic defect. The extent of soft tissue and bony injury can be accurately assessed, and the operative plan tailored to each individual patient. This aspect can also be utilized to create patient- and defect-specific implants (polymethylmethacrylate or titanium) to aid in reconstruction. Further, stereolithic models can be created, allowing for model surgery to be performed in a test run before the actual procedure. This allows for preoperative modification of the treatment plan and more accurate determination of the reconstructive needs of the case, as well as allowing for prebending of reconstruction plates. Clinical Care Relevance: Improved preoperative imaging techniques allow for better and more individualized surgical planning, shortened operative times, and improved outcomes. The ability to perform model surgery results in shortened operative times and improved outcomes. Conclusion: The widespread use of high-velocity weapons and explosive devices in modern combat has resulted in devastating complex craniomaxillofacial injuries. The ability to restore form and function to these patients is extremely challenging. Three-dimensional stereolithic models generated from fine-cut computed tomography scans have been employed to enhance preoperative counseling and preoperative planning, to reduce operative times and to improve functional and cosmetic outcomes. C1 [Littlefield, Phillip; Cote, Christopher; Coppit, George] Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Washington, DC 20307 USA. RP Coppit, G (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.coppit@us.army.mil NR 9 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 70 EP 76 DI 10.1089/awc.2009.0025 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600013 ER PT B AU Gurjala, AN Schierle, CF Galiano, RD Leung, KP Mustoe, TA AF Gurjala, Anandev N. Schierle, Clark F. Galiano, Robert D. Leung, Kai P. Mustoe, Thomas A. BE Sen, CK TI Animal Models of Biofilm-Infected Wound Healing SO ADVANCES IN WOUND CARE, VOL 1: TRANSLATIONAL MEDICINE: FROM BENCHTOP TO BEDSIDE TO COMMUNITY AND BACK SE Advances in Wound Care LA English DT Article; Book Chapter ID BACTERIAL BIOFILMS; PATHOGENESIS; HYPOTHESIS; STRATEGIES AB Background: The presence of bacterial biofilms in chronic wounds has emerged as a major potential etiology in their pathogenesis. The ability of bacterial biofilms to induce localized inflammatory states with clinically significant effects has been confirmed in other disease states and is an attractive hypothesis for the inflammatory arrest observed in diabetic foot ulcers, pressure ulcers, and venous stasis ulcers. The Problem: In vitro biofilm models will continue to provide valuable information especially in the areas of bacterial genetics and mechanisms of resistance and treatment. Due to the complex interaction between bacterial biofilms and host factors such as the local wound environment and the immune response, in vivo biofilm wound models will also be necessary for conducting clinically relevant studies. Basic/Clinical Science Advances: Biofilms have been positively identified in human chronic wounds, and similar techniques have now been used to identify experimentally induced biofilm in the wounds of murine, rat, and porcine animal models. Assessment of wound-healing kinetics in the presence of biofilm has confirmed causality between biofilm and impaired wound healing using animal models. Clinical Care Relevance: The possibility that bacterial biofilms are a common etiology in the impaired healing of all types of chronic wounds makes them an obvious therapeutic target with the potential for large clinical impact. Conclusion: Although still in their early stages, recently developed animal models will be essential in answering fundamental questions about biofilm behavior in vivo, the host response to biofilm, and the effectiveness of antibiofilm treatment strategies. C1 [Gurjala, Anandev N.; Schierle, Clark F.; Galiano, Robert D.; Mustoe, Thomas A.] NW Feinberg Sch Med, Dept Surg, Div Plast Surg, Lab Wound Repair & Regenerat Med, Chicago, IL USA. [Leung, Kai P.] Walter Reed Army Inst Res, Microbiol Branch, Great Lakes, IL USA. RP Mustoe, TA (reprint author), 675 North St Clair,Suite 19-250, Chicago, IL 60611 USA. EM tmustoe@nmh.org NR 18 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 USA BN 978-1-934854-01-3 J9 ADV WOUND CARE PY 2010 VL 1 BP 305 EP 310 DI 10.1089/awc.2009.0094 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA BOV75 UT WOS:000277780600051 ER PT J AU Kesavan, J Schepers, D McFarland, AR AF Kesavan, Jana Schepers, Deborah McFarland, Andrew R. TI Sampling and Retention Efficiencies of Batch-Type Liquid-Based Bioaerosol Samplers SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID COLLECTION EFFICIENCY; AEROSOL COLLECTION; PARTICLES; MICROORGANISMS; PERFORMANCE; IMPINGERS; IMPACTION; CYCLONE AB Four commercially available batch-type bioaerosol samplers, which collect time-integrated samples in liquids, were evaluated. Sampling efficiency was characterized as a function of particle size using near-monodisperse polystyrene spheres (sizes of 1-5 mu m) and oleic acid droplets (3-10 mu m). Results show the sampling efficiency of AGI-30 impingers range from 4-67% for particle sizes of 1 to 5.1 mu m with significant variations between units; those of SKC BioSampler impingers range from 34-105% for particle sizes from 1 to 9 mu m; those of a batch-type wetted wall cyclone with compensation for evaporation (BWWC-EC) range from 5 to 65% for particle sizes 1 to 10 mu m; and, those of a batch-type wetted wall cyclone with no evaporation compensation (BWWC-NC) range of 55 to 88% for particle sizes of 1-8 mu m. Retention efficiency was measured for 1 and 10 mu m polystyrene spheres. For the AGI-30 and BWWC-EC, the retention efficiency of 1 mu m particles after 1 h was less than 30%, while that of the SKC BioSampler was 59%. Due to liquid evaporation, the BWWC-NC could not be operated for 1 h. Retention efficiencies for Bacillus atrophaeus spores and Pantoea agglomerans vegetative cells were measured for the AGI-30 and the SKC BioSampler. Results for the spores were about the same as those for 1 mu m non-viable polystyrene particles; however, the vegetative bacteria lose culturability and consequently show lower retention efficiencies. For the impingers, significant performance differences were observed in units delivered by vendors at different times. C1 [Kesavan, Jana] USA, Aerosol Sci Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Schepers, Deborah] Noblis Inc, Falls Church, VA USA. [McFarland, Andrew R.] Andrew R McFarland PhD PE Inc, Houston, TX USA. RP Kesavan, J (reprint author), USA, Aerosol Sci Branch, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. EM jana.kesavan@us.army.mil NR 26 TC 15 Z9 15 U1 2 U2 11 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 2010 VL 44 IS 10 BP 817 EP 829 DI 10.1080/02786826.2010.497513 PG 13 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 668WS UT WOS:000283305300002 ER PT J AU Arroyo, MA Phanuphak, N Krasaesub, S Sirivichayakul, S Assawadarachai, V Poltavee, K Pankam, T Ananworanich, J Paris, R Tovanabutra, S Kijak, GH McCutchan, FE Phanuphak, P Kim, JH de Souza, M AF Arroyo, Miguel A. Phanuphak, Nittaya Krasaesub, Somporn Sirivichayakul, Sunee Assawadarachai, Vatcharain Poltavee, Kultida Pankam, Tippawan Ananworanich, Jintanat Paris, Robert Tovanabutra, Sodsai Kijak, Gustavo H. McCutchan, Francine E. Phanuphak, Praphan Kim, Jerome H. de Souza, Mark TI HIV Type 1 Molecular Epidemiology among High-Risk Clients Attending the Thai Red Cross Anonymous Clinic in Bangkok, Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID INJECTING DRUG-USERS; CIRCULATING RECOMBINANT FORM; CRF01-AE/B RECOMBINANT; ENVELOPE SUBTYPES; INFECTION; CRF15-01B; TRIALS; ASSAY; AIDS AB Several studies have reported an increasing number of non-CRF01_AE infections in high-risk groups in Thailand suggesting a more complex HIV-1 epidemic. This study assessed the complexity of the HIV epidemic among high-risk clients tested for HIV-1 at the Thai Red Cross Anonymous Clinic (TRCAC) between July 1, 2006 and February 28, 2007. HIV-1 genotypes were determined from plasma of infected subjects (n=401) by the multi-region hybridization assay (MHAbce, v. 2). Univariate and multivariate logistic regression analyses were used to determine risk factors associated with HIV prevalence and non-CRF01_AE infection. The estimated overall HIV prevalence was 14.1%: 25.3% among men who have sex with men (MSM), 18.4% among heterosexual women, and 9.6% among heterosexual men. Among the risk factors found to be associated with HIV prevalence were age (25-29 years), risk behavior (MSM), marital status (not single), education (less than high school), and inconsistent condom use. Overall, non-CRF01_AE strains accounted for 18.9% of the infections: 25.3% among MSM and 14.8% and 20.4% among heterosexual women and men, respectively. Our results indicate a concentrated and genetically complex HIV epidemic among Thai MSM. These findings advocate for targeted intervention and prevention measures among high-risk populations in Thailand. C1 [Arroyo, Miguel A.; Krasaesub, Somporn; Assawadarachai, Vatcharain; Poltavee, Kultida; Paris, Robert; de Souza, Mark] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Phanuphak, Nittaya; Pankam, Tippawan; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok 10330, Thailand. [Sirivichayakul, Sunee] Chulalongkorn Univ, Fac Med, Bangkok 10330, Thailand. [Ananworanich, Jintanat] SEARCH, Bangkok 10330, Thailand. [Tovanabutra, Sodsai; Kijak, Gustavo H.; McCutchan, Francine E.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD 20850 USA. [McCutchan, Francine E.] Bill & Melinda Gates Fdn, Seattle, WA 98102 USA. [Kim, Jerome H.] US Mil HIV Res Program, Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD 20850 USA. RP de Souza, M (reprint author), Armed Forces Res Inst Med Sci, Dept Retrovirol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM Mark.Desouza@afrims.org OI Arroyo, Miguel/0000-0001-7416-8867 FU U.S. Military [1383, RV225]; Chulalongkorn University, Bangkok, Thailand FX This study was supported and approved by the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research (WRAIR protocol # 1383, RV225) and by the Chulalongkorn University, Bangkok, Thailand. The material has been reviewed by the Walter Reed Army Institute of Research and there is no objection to its presentation and/or publication. The authors would like to thank the management and employees of the Thai Red Cross Anonymous Clinic for their invaluable assistance and cooperation during the conduct of this study, including Dr. Mana Khongphatthanayothin. The Walter Reed Army Institute of Research Institutional Research Board human use protocol no. 1383 (RV225), "The Molecular Epidemiology of HIV-1 among HIV Blood Testing Clients Attending the Thai Red Cross Anonymous Clinic in Bangkok, Thailand,'' is funded through the U. S. Military HIV Research Program ( the Walter Reed Army Institute of Research and the Henry M. Jackson Foundation for the Advancement of Military Medicine). The views expressed here are the opinions of the authors and are not to be considered as official or reflecting the views of the Walter Reed Army Institute of Research, the Armed Forces Medical Research Institute, the U. S. Army, or the U. S. Department of Defense; the Thai Red Cross AIDS Research Centre; the Henry M. Jackson Foundation for the Advancement of Military Medicine; the Chulalongkorn University; and the South East Asia Research Collaboration with Hawaii. NR 23 TC 25 Z9 25 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JAN PY 2010 VL 26 IS 1 BP 5 EP 12 DI 10.1089/aid.2009.0150 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 551EY UT WOS:000274190700002 PM 20055593 ER PT J AU Marconi, VC Grandits, GA Weintrob, AC Chun, H Landrum, ML Ganesan, A Okulicz, JF Crum-Cianflone, N O'Connell, RJ Lifson, A Wortmann, GW Agan, BK AF Marconi, Vincent C. Grandits, Greg A. Weintrob, Amy C. Chun, Helen Landrum, Michael L. Ganesan, Anuradha Okulicz, Jason F. Crum-Cianflone, Nancy O'Connell, Robert J. Lifson, Alan Wortmann, Glenn W. Agan, Brian K. CA Infect Dis Clinical Res Program TI Outcomes of highly active antiretroviral therapy in the context of universal access to healthcare: the US Military HIV Natural History Study SO AIDS RESEARCH AND THERAPY LA English DT Article AB Background: To examine the outcomes of highly-active antiretroviral therapy (HAART) for individuals with free access to healthcare, we evaluated 2327 patients in a cohort study composed of military personnel and beneficiaries with HIV infection who initiated HAART from 1996 to the end of 2007. Methods: Outcomes analyzed were virologic suppression (VS) and failure (VF), CD4 count changes, AIDS and death. VF was defined as never suppressing or having at least one rebound event. Multivariate (MV) analyses stratified by the HAART initiation year (before or after 2000) were performed to identify risk factors associated with these outcomes. Results: Among patients who started HAART after 2000, 81% had VS at 1 year (N = 1,759), 85% at 5 years (N = 1,061), and 82% at 8 years (N = 735). Five years post-HAART, the median CD4 increase was 247 cells/ml and 34% experienced VF. AIDS and mortality rates at 5 years were 2% and 0.3%, respectively. In a MV model adjusted for known risk factors associated with treatment response, being on active duty (versus retired) at HAART initiation was associated with a decreased risk of AIDS (HR = 0.6, 95% CI 0.4-1.0) and mortality (0.6, 0.3-0.9), an increased probability of CD4 increase = 50% (1.2, 1.0-1.4), but was not significant for VF. Conclusions: In this observational cohort, VS rates approach those described in clinical trials. Initiating HAART on active duty was associated with even better outcomes. These findings support the notion that free access to healthcare likely improves the response to HAART thereby reducing HIV-related morbidity and mortality. C1 [Marconi, Vincent C.; Grandits, Greg A.; Weintrob, Amy C.; Chun, Helen; Landrum, Michael L.; Ganesan, Anuradha; Okulicz, Jason F.; Crum-Cianflone, Nancy; O'Connell, Robert J.; Lifson, Alan; Wortmann, Glenn W.; Agan, Brian K.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Marconi, Vincent C.; Landrum, Michael L.; Okulicz, Jason F.] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA. [Grandits, Greg A.; Lifson, Alan] Univ Minnesota, Div Biostat, Minneapolis, MN USA. [Weintrob, Amy C.; Crum-Cianflone, Nancy; Wortmann, Glenn W.] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. [Chun, Helen] Naval Med Ctr San Diego, Infect Dis Clin, San Diego, CA USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Infect Dis Clin, Bethesda, MD USA. [O'Connell, Robert J.] Walter Reed Army Inst Res, Rockville, MD USA. [Marconi, Vincent C.] Emory Univ, Sch Med, Atlanta, GA USA. RP Marconi, VC (reprint author), Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. EM vcmarco@emory.edu; bagan@idcrp.org RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 FU Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program through the Uniformed Services University of the Health Sciences [IDCRP-000-03]; National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) [Y1-AI-5072] FX Support for this work (IDCRP-000-03) was provided by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole, or in part, with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under Inter-Agency Agreement Y1-AI-5072. This support included study design, data collection, analysis, data interpretation, manuscript writing, and submission. NR 60 TC 40 Z9 40 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-6405 J9 AIDS RES THER JI Aids Res. Ther. PY 2010 VL 7 AR 14 DI 10.1186/1742-6405-7-14 PG 10 WC Infectious Diseases SC Infectious Diseases GA V29JM UT WOS:000208744700014 PM 20507622 ER PT S AU Fleming, SD AF Fleming, Steven D. BE Henry, DJ TI Terrestrial imaging of military test centers SO AIRBORNE INTELLIGENCE, SURVEILLANCE, RECONNAISSANCE (ISR) SYSTEMS AND APPLICATIONS VII SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Airborne Intelligence, Surveillance, Reconnaissance (ISR) Systems and Applications VII CY APR 07-08, 2010 CL Orlando, FL SP SPIE DE iPIX; terrestrial imaging; videography; immersive media; GIS; Army test centers AB Military test centers require detailed site descriptions. Test agencies demand significant written and visual information of test sites in order to facilitate successful test preparation and execution. New terrestrial imaging techniques (360 degree FOV collection) have recently become feasible to collect in the field. Combined with GIS and mapping applications, image and video data is now provided to test agencies for their use. Test sites for this study include locations in Alaska and Panama with planned image data collection in Arizona and Maryland. C1 US Mil Acad, Ctr Environm & Geog Sci, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Fleming, SD (reprint author), US Mil Acad, Ctr Environm & Geog Sci, Dept Geog & Environm Engn, 745 Brewerton Rd,Room 5303A, West Point, NY 10996 USA. EM steven.fleming@usma.edu NR 11 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8132-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7668 AR 76680D DI 10.1117/12.852672 PG 10 WC Remote Sensing; Optics; Imaging Science & Photographic Technology SC Remote Sensing; Optics; Imaging Science & Photographic Technology GA BSS38 UT WOS:000285628000012 ER PT S AU Gurram, P Kwon, H AF Gurram, Prudhvi Kwon, Heesung BE Shen, SS Lewis, PE TI Ensemble Learning based on Multiple Kernel Learning for Hyperspectral Chemical Plume Detection SO ALGORITHMS AND TECHNOLOGIES FOR MULTISPECTRAL, HYPERSPECTRAL, AND ULTRASPECTRAL IMAGERY XVI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XVI CY APR 05-08, 2010 CL Orlando, FL SP SPIE DE SVM; Ensemble learning; Multiple Kernel Learning; Chemical plume detection AB Recently, a SVM-based ensemble learning technique has been introduced by the authors for hyperspectral plume detection/classification. The SVM-based ensemble learning consists of a number of SVM classifiers and the decisions from these sub-classifiers are combined to generate a final ensemble decision. The SVM-based ensemble technique first randomly selects spectral feature subspaces from the input data. Each individual classifier then independently conducts its own learning within its corresponding spectral feature space. Each classifier constitutes a weak classifier. These weak classifiers are combined to make an ensemble decision. The ensemble learning technique provides better performance than the conventional single SVM in terms of error rate. Various aggregating techniques like bagging, boosting, majority voting and weighted averaging were used to combine the weak classifiers, of which majority voting was found to be most robust. Yet, the ensemble of SVMs is suboptimal. Techniques that optimally weight the individual decisions from the sub-classifiers are strongly desirable to improve ensemble learning performance. In the proposed work, a recently introduced kernel learning technique called Multiple Kernel Learning (MKL) is used to optimally weight the kernel matrices of the sub-SVM classifiers. MKL basically iteratively performs l2 optimization on the Euclidian norm of the normal vector of the separating hyperplane between the classes (background and chemical plume) defined by the weighted kernel matrix followed by gradient descent optimization on the l1 regularized weighting coefficients of the individual kernel matrices. Due to l1 regularization on the weighting coefficients, the optimized weighting coefficients become sparse. The proposed work utilizes the sparse weighting coefficients to combine decision results of the SVM-based ensemble technique. A performance comparison between the aggregating techniques - MKL and majority voting as applied to hyperspectral chemical plume detection is presented in the paper. C1 [Gurram, Prudhvi; Kwon, Heesung] USA, Res Lab, Image Proc Branch, Adelphi, MD 20783 USA. RP Kwon, H (reprint author), USA, Res Lab, Image Proc Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM heesung.kwon@arl.army.mil NR 9 TC 1 Z9 1 U1 2 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8159-7 J9 P SOC PHOTO-OPT INS PY 2010 VL 7695 AR 76951U DI 10.1117/12.850101 PG 11 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BSS80 UT WOS:000285716700064 ER PT S AU Rauss, P Kwon, H AF Rauss, Patrick Kwon, Heesung BE Shen, SS Lewis, PE TI Use of Ensemble Learning Technique for Detection/Identification of Chemical Plumes SO ALGORITHMS AND TECHNOLOGIES FOR MULTISPECTRAL, HYPERSPECTRAL, AND ULTRASPECTRAL IMAGERY XVI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XVI CY APR 05-08, 2010 CL Orlando, FL SP SPIE DE Hyperspectral images; Support vector machines; SVMs; ensemble technique; chemical detection AB An ensemble learning approach using a number of weak classifiers, each classifier conducting learning based on a random subset of spectral features (bands) of the training sample, is used to detect/identify a specific chemical plume. The support vector machine (SVM) is used as the weak classifier. The detection results of the multiple SVMs are combined to generate a final decision on a pixel's class membership. Due to the multiple learning processes conducted in the randomly selected spectral subspaces, the proposed ensemble learning can improve solution generality. This work uses a two-class approach, using samples taken from hyper-spectral image (HSI) cubes collected during a release of the test chemical. Performance results in the form of receiver operator characteristic curves, show similar performance when compared to a single SVM using the full spectrum. Initial results were obtained by training with samples taken from a single HSI cube. These results are compared to results that are more recent from training with sample data from 28 HSI cubes. Performance of algorithms trained with high concentration spectra show very strong responses when scored only on high concentration data. However, performance drops substantially when low concentration pixels are scored as well. Training with the low concentration pixels along with the high concentration pixels can improve over all solution generality and shows the strength of the ensemble approach. However, it appears that careful selection of the training data and the number of examples can have a significant impact on performance. C1 [Rauss, Patrick; Kwon, Heesung] USA, Res Lab, Image Proc Branch, Adelphi, MD 20783 USA. RP Rauss, P (reprint author), USA, Res Lab, Image Proc Branch, 2800 Powder Mill RD, Adelphi, MD 20783 USA. RI Rauss, Patrick/A-3029-2011 NR 4 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8159-7 J9 P SOC PHOTO-OPT INS PY 2010 VL 7695 AR 76951T DI 10.1117/12.850039 PG 10 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BSS80 UT WOS:000285716700063 ER PT S AU Rosario, D Kling, H AF Rosario, Dalton Kling, Henry BE Shen, SS Lewis, PE TI Hyperspectral object tracking using small sample size SO ALGORITHMS AND TECHNOLOGIES FOR MULTISPECTRAL, HYPERSPECTRAL, AND ULTRASPECTRAL IMAGERY XVI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XVI CY APR 05-08, 2010 CL Orlando, FL SP SPIE DE Target tracking; hyperspectral imagery; IBM Cell Processor AB This paper introduces a simple approach for object tracking using hyperspectral (HS) spectral features. The approach addresses the object tracking problem using a small object sample size. For a particular application, the key challenges are: (i) Offline training cannot be utilized; (ii) motor vehicles of interest (targets) have a small sample size (e. g., less than 9); and (iii) kinematic states of targets cannot be used for tracking, since stationary targets are also of interest. Using HS imagery, this paper introduces a method that exploits the mean and median averages spectra to estimate higher moments of the underlying (and unknown) probability distribution function of spectra; in particular, skew tendency and sign. Tracking HS targets is then possible using this algorithm to test a sequence of HS imagery, given that target spectra are initially cued by the user. The approach was implemented into a commercially off the shelf workstation, featuring the IBM Cell Processor and GA-180 Add in Board. Preliminary results are promising using a challenging HS data cube. C1 [Rosario, Dalton] USA, Res Lab, Adelphi, MD 20783 USA. RP Rosario, D (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM dalton.rosario@us.army.mil NR 8 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8159-7 J9 P SOC PHOTO-OPT INS PY 2010 VL 7695 AR 76950I DI 10.1117/12.850359 PG 9 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BSS80 UT WOS:000285716700017 ER PT S AU Wozencraft, JM AF Wozencraft, Jennifer M. BE Shen, SS Lewis, PE TI Requirements for the Coastal Zone Mapping and Imaging Lidar (CZMIL) SO ALGORITHMS AND TECHNOLOGIES FOR MULTISPECTRAL, HYPERSPECTRAL, AND ULTRASPECTRAL IMAGERY XVI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XVI CY APR 05-08, 2010 CL Orlando, FL SP SPIE DE CZMIL; SHOALS; CHARTS; lidar bathymetry; lidar topography; RGB imagery; hyperspectral imagery; coastal mapping AB The U.S. Army Corps of Engineers (USACE) began developing airborne lidar bathymetry systems for coastal mapping applications in 1986, and fielded its first system in 1994. In the ensuing years, the Scanning Hydrographic Operational Airborne Lidar Survey research and development program led to the creation of the Joint Airborne Lidar Bathymetry Technical Center of Expertise (JALBTCX), a robust federal government partnership in airborne lidar bathymetry; the USACE National Coastal Mapping Program, a program of mapping built around airborne lidar bathymetry and complementary airborne remote sensing technologies; and a healthy commercial field of airborne lidar bathymeter manufacturers and service providers. The Coastal Zone Mapping and Imaging Lidar (CZMIL) is a new USACE sensor development effort and a partnership among the JALBTCX, Optech International, and The University of Southern Mississippi. The goal of CZMIL is to produce an integrated lidar and imagery sensor suite and software package designed for highly automated generation of physical and environmental information products for the coastal zone. CZMIL is an opportunity to revamp existing hardware and software to address the turbidity and shallow water limitations of existing systems; improve environmental applications of the data; take advantage of advances in laser, scanner, and receiver technology, and in signal processing and data fusion algorithms; while maintaining accurate depth measurement capability. The CZMIL program has been underway since 2006, resulting in a detailed design of the CZMIL software and hardware. CZMIL fabrication will be complete in 2010 and fielded in USACE operations in 2011. C1 USA, Corps Engineers Engineer Res & Dev Ctr, Joint Airborne Lidar Bathymetry Tech Ctr Expertis, Kiln, MS 39556 USA. RP Wozencraft, JM (reprint author), USA, Corps Engineers Engineer Res & Dev Ctr, Joint Airborne Lidar Bathymetry Tech Ctr Expertis, 7225 Stennis Airport Rd,Suite 100, Kiln, MS 39556 USA. EM jennifer.m.wozencraft@usace.army.mil NR 19 TC 5 Z9 5 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8159-7 J9 PROC SPIE PY 2010 VL 7695 AR 76950Q DI 10.1117/12.851891 PG 7 WC Optics; Imaging Science & Photographic Technology SC Optics; Imaging Science & Photographic Technology GA BSS80 UT WOS:000285716700024 ER PT J AU Wain, HJ Dailey, J AF Wain, Harold J. Dailey, Jason TI A Dissociative Episode Following Stage Hypnosis in a Combat-Injured Soldier: Implications, Treatment and Reflections SO AMERICAN JOURNAL OF CLINICAL HYPNOSIS LA English DT Article DE Dissociation disorder nos; stage hypnosis; trauma ID POSTTRAUMATIC STRESS DISORDER; HYPNOTIZABILITY AB Significant data to suggest the need for more appropriate precautions for volunteers participating in stage hypnosis is presented. This paper is a case report of a soldier previously injured in battle who, due to participating in stage hypnosis one year after his injury, experienced a dissociative episode wherein post-traumatic stress symptoms were prominent. During this episode, which lasted over three hours, the service member assaulted an acquaintance, Subsequently believed lie was a prisoner of war, experienced amnesia for some of the events, and was eventually psychiatrically hospitalized. The diagnosis of acute psychotic reaction was rendered. Fortunately for this service member, upon his return to his treating hospital center, his primary medical team made an appropriate referral. Psychotherapeutic treatment allowed this individual to integrate his traumatic experiences, gain control and understanding of his behavior, and extinguish his pain and suffering, returning to his successful career. C1 [Wain, Harold J.] USUHS, Dept Psychiat, Walter Reed Army Med Ctr, Chief Psychiat Consultat Liaison Serv, Washington, DC 20307 USA. RP Wain, HJ (reprint author), USUHS, Dept Psychiat, Walter Reed Army Med Ctr, Chief Psychiat Consultat Liaison Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM harold.wain@amedd.army.mil NR 24 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL HYPNOSIS PI BLOOMINGDALE PA 140 N BLOOMINGDALE RD, BLOOMINGDALE, IL 60108-1017 USA SN 0002-9157 J9 AM J CLIN HYPN JI Am. J. Clin. Hypn. PD JAN PY 2010 VL 52 IS 3 BP 183 EP 188 PG 6 WC Psychology, Clinical SC Psychology GA 543LV UT WOS:000273580100007 PM 20187337 ER PT J AU Allen, D AF Allen, David TI Larry and the Feds SO AMERICAN JOURNAL OF ECONOMICS AND SOCIOLOGY LA English DT Biographical-Item C1 [Allen, David] USA, Washington, DC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-9246 J9 AM J ECON SOCIOL JI Am. J. Econ. Sociol. PD JAN PY 2010 VL 69 IS 1 BP 203 EP 205 PG 3 WC Economics; Sociology SC Business & Economics; Sociology GA 546OV UT WOS:000273821000019 ER PT J AU Cheezum, MK Willis, SL Duffy, SP Moawad, FJ Horwhat, JD Huffer, LL Welch, TS AF Cheezum, Michael K. Willis, Scott L. Duffy, Sean P. Moawad, Fouad J. Horwhat, John D. Huffer, Linda L. Welch, Timothy S. TI Broken Pancreas, Broken Heart SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter ID CARDIOMYOPATHY C1 [Willis, Scott L.; Huffer, Linda L.; Welch, Timothy S.] Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, Washington, DC 20307 USA. [Cheezum, Michael K.; Duffy, Sean P.] Walter Reed Army Med Ctr, Dept Med, Internal Med Serv, Washington, DC 20307 USA. [Moawad, Fouad J.; Horwhat, John D.] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. RP Welch, TS (reprint author), Walter Reed Army Med Ctr, Dept Med, Serv Cardiol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Timothy.Welch@amedd.army.mil NR 4 TC 4 Z9 4 U1 0 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JAN PY 2010 VL 105 IS 1 BP 237 EP 238 DI 10.1038/ajg.2009.520 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 548VG UT WOS:000273996200051 PM 20054329 ER PT J AU Cole, RE Horacek, T AF Cole, Renee E. Horacek, Tanya TI Effectiveness of the "My Body Knows When" Intuitive-eating Pilot Program SO AMERICAN JOURNAL OF HEALTH BEHAVIOR LA English DT Article DE intuitive eating; nondieting; participatory program planning ID WEIGHT MANAGEMENT; DIETARY RESTRAINT; PHYSICAL-ACTIVITY; MASS INDEX; FOOD; INTERVENTION; DIETERS; HEALTH; WOMEN; OBESE AB Objective: To evaluate the effectiveness of the "My Body Knows When" intuitive-eating (IE) program tailored to assist Fort Drum military spouses in rejecting the dieting mentality. Methods: Randomized prospective study (N=61) evaluating dieting mentality and health indicators for a 10-week intervention based on 10 IE principles. The program was developed through the PRECEDE / PROCEED (PP) health promotion planning model. Results: The intuitive-eating program was able to significantly transition participants away from a dieting mentality (P<0.015 posttest) towards intuitive-eating lifestyle behaviors. Conclusions: IE is a holist approach to long-term healthy behavior change and would benefit from an extended support system to improve effectiveness. C1 [Cole, Renee E.] USA, US Mil Dietet Internship Consortium, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. [Horacek, Tanya] Syracuse Univ, Didact Program Dietet, Dept Nutr Sci & Dietet, Syracuse, NY USA. RP Cole, RE (reprint author), ATTN MCCS HGE GN, AMEDD Ctr & Sch, 2250 Stanley Rd,RM 1140, Ft Sam Houston, TX 78234 USA. EM renee.e.cole@us.army.mil RI Horacek, Tanya/D-6355-2013 NR 36 TC 17 Z9 17 U1 5 U2 21 PU PNG PUBLICATIONS PI OAK RIDGE PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA SN 1945-7359 J9 AM J HEALTH BEHAV JI Am. J. Health Behav. PY 2010 VL 34 IS 3 BP 286 EP 297 PG 12 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 781LE UT WOS:000291932900004 PM 20001186 ER PT J AU Lentine, KL Hurst, FP Jindal, RM Villines, TC Kunz, JS Yuan, CM Hauptman, PJ Abbott, KC AF Lentine, Krista L. Hurst, Frank P. Jindal, Rahul M. Villines, Todd C. Kunz, Jeffrey S. Yuan, Christina M. Hauptman, Paul J. Abbott, Kevin C. TI Cardiovascular Risk Assessment Among Potential Kidney Transplant Candidates: Approaches and Controversies SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Review DE Cardiovascular disease; kidney transplant; myocardial revascularization; physicians' practice patterns; risk assessment ID CORONARY-ARTERY-DISEASE; STAGE RENAL-DISEASE; DOBUTAMINE STRESS ECHOCARDIOGRAPHY; PRACTICE GUIDELINES COMMITTEE; CONTRAST-INDUCED NEPHROPATHY; LEFT-VENTRICULAR DYSFUNCTION; CONGESTIVE-HEART-FAILURE; ASSOCIATION TASK-FORCE; PROGNOSTIC VALUE; DIABETIC-PATIENTS AB Cardiovascular disease is the most common cause of death after kidney transplantation. However, uncertainties regarding the optimal assessment of cardiovascular risk in potential transplant candidates have produced controversy and inconsistency in pretransplantation cardiac evaluation practices. In this review, we consider the evidence supporting cardiac evaluation in kidney transplant candidates, generally focused on coronary artery disease, according to the World Health Organization principles for screening. The importance of pretransplant cardiac evaluation is supported by the high prevalence of coronary artery disease and the incidence and adverse consequences of acute coronary syndromes in this population. Testing for coronary artery disease may be performed noninvasively by using modalities that include nuclear myocardial perfusion studies and dobutamine stress echocardiography. These tests have prognostic value for mortality, but imperfect sensitivity and specificity for detecting angiographically defined coronary artery disease in patients with end-stage renal disease. Associations of angiographically-defined coronary artery disease with subsequent survival also are inconsistent, likely because plaque instability is more critical for infarction risk than angiographic stenosis. The efficacy and best methods of myocardial revascularization have not been examined in large contemporary clinical trials in patients with end-stage renal disease. Biomarkers, such as cardiac troponin, have prognostic value in end-stage renal disease, but require further study to determine clinical applications in directing more expensive and invasive cardiac evaluation. Am J Kidney Dis 55: 152-167. (C) 2009 by the National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. C1 [Lentine, Krista L.; Hauptman, Paul J.] St Louis Univ, Ctr Outcomes Res, Sch Med, St Louis, MO 63104 USA. [Lentine, Krista L.] St Louis Univ, Div Nephrol, Sch Med, St Louis, MO 63104 USA. [Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Serv, Washington, DC 20307 USA. [Jindal, Rahul M.] Brookdale Univ Hosp & Med Ctr, Dept Surg, Brooklyn, NY USA. [Villines, Todd C.; Kunz, Jeffrey S.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Hauptman, Paul J.] St Louis Univ, Div Cardiol, Sch Med, St Louis, MO 63104 USA. RP Lentine, KL (reprint author), St Louis Univ, Ctr Outcomes Res, Sch Med, Salus Ctr 2nd Fl,3545 Lafayette Ave, St Louis, MO 63104 USA. EM lentine.krista@stanfordalumni.org OI Villines, Todd/0000-0003-2674-3702; Abbott, Kevin/0000-0003-2111-7112 FU National Institute of Diabetes Digestive and Kidney Diseases [K08DK073036] FX Dr Lentine is supported by a grant from the National Institute of Diabetes Digestive and Kidney Diseases, K08DK073036. NR 90 TC 32 Z9 34 U1 0 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD JAN PY 2010 VL 55 IS 1 BP 152 EP 167 DI 10.1053/j.ajkd.2009.06.032 PG 16 WC Urology & Nephrology SC Urology & Nephrology GA 548JN UT WOS:000273958000021 PM 19783341 ER PT J AU Salifu, MO Abbott, KC Aytug, S Hayat, A Haria, DM Shah, S Friedman, EA Delano, BG McFarlane, SI Hurst, FP Flom, PL Jindal, RM AF Salifu, Moro O. Abbott, Kevin C. Aytug, Serhat Hayat, Amir Haria, Dhiren M. Shah, Syed Friedman, Eli A. Delano, Barbara G. McFarlane, Samy I. Hurst, Frank P. Flom, Peter L. Jindal, Rahul M. TI New-Onset Diabetes after Hemodialysis Initiation: Impact on Survival SO AMERICAN JOURNAL OF NEPHROLOGY LA English DT Article DE Diabetes; Hemodialysis; End-stage renal disease; New-onset diabetes after initiation of hemodialysis (NODAD); NODAD, mortality; NODAD, survival ID STAGE RENAL-DISEASE; CARDIOVASCULAR RISK-FACTORS; IMMORTAL TIME BIAS; OXIDATIVE STRESS; ELDERLY POPULATION; INSULIN-RESISTANCE; INFLAMMATION; ATHEROSCLEROSIS; MALNUTRITION; ASSOCIATION AB Background: The incidence of new-onset diabetes after initiation of hemodialysis (NODAD) and its impact on survival is not known. Methods: We used data from the United States Renal Data System (USRDS) from January 2000 to December 2001, with at least 3 years of follow-up for this study. Patients aged 18-80 years were included. NODAD was defined as two Medicare institutional claims for diabetes in patients with no history of diabetes prior to starting hemodialysis (HD). Incidence (per 1,000 patient-years), prevalence (%) and hazard ratios for mortality in patients with NODAD were calculated. Results: There were 59,340 incident patients with no history of diabetes prior to starting HD, of which 3,853 met criteria for NODAD. The overall incidence and prevalence of NODAD were 20 per 1,000 patient-years and 7.6%, respectively. In a cohort of 444 patients without diabetes and documented glycosylated hemoglobin A1c, <6% prior to starting HD (from January 2005 and March 2006), at a mean follow-up of 4.7 +/- 2.6 months, 6.8% developed NODAD defined by two Medicare claims for diabetes after initiation of HD. NODAD was associated with a significantly increased risk of death as compared to non-diabetes patients (hazard ratio 1.20, 95% confidence interval 1.14-1.25). Conclusion: The USRDS showed a high incidence of NODAD, associated with significantly higher mortality compared to those who did not develop NODAD. The mechanism of NODAD needs to be explored further in experimental and clinical studies. Copyright (C) 2010 S. Karger AG, Basel C1 [Abbott, Kevin C.; Hurst, Frank P.; Jindal, Rahul M.] Walter Reed Army Med Ctr, Organ Transplant Program, Washington, DC 20307 USA. [Abbott, Kevin C.; Hurst, Frank P.] Walter Reed Army Med Ctr, Div Nephrol, Washington, DC 20307 USA. [Salifu, Moro O.; Hayat, Amir; Haria, Dhiren M.; Shah, Syed; Friedman, Eli A.; Delano, Barbara G.] Suny Downstate Med Ctr, Div Nephrol, Brooklyn, NY 11203 USA. [Aytug, Serhat] Crystal Run Healthcare, Div Endocrinol, Middletown, NY USA. [McFarlane, Samy I.] Suny Downstate Med Ctr, Div Endocrinol, Brooklyn, NY 11203 USA. [Jindal, Rahul M.] Brookdale Univ Hosp & Med Ctr, Brooklyn, NY USA. [Jindal, Rahul M.] George Washington Univ, Washington, DC USA. [Flom, Peter L.] Suny Downstate Med Ctr, Ctr Comp Sci, Brooklyn, NY 11203 USA. RP Jindal, RM (reprint author), Walter Reed Army Med Ctr, Organ Transplant Program, Washington, DC 20307 USA. EM Jindalr@msn.com OI Abbott, Kevin/0000-0003-2111-7112 FU Research Foundation of SUNY Downstate Medical Center [30412] FX Supported in part by an institutional grant #30412 from The Research Foundation of SUNY Downstate Medical Center. NR 34 TC 8 Z9 8 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0250-8095 J9 AM J NEPHROL JI Am. J. Nephrol. PY 2010 VL 31 IS 3 BP 239 EP 246 DI 10.1159/000276542 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA 570LE UT WOS:000275678400007 PM 20068288 ER PT J AU Usher, BM Casey, K Echard, JC AF Usher, Bethany M. Casey, Kalen Echard, Jessica Crandall TI "Standard" cemetery population from fluctuating residential patterns: A decade-by-decade comparison of census records and cemetery demography from the St. Lawrence County Almshouse. SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Meeting Abstract CT 79th Annual Meeting of the American-Association-of-Physical-Anthropologists CY APR 14-17, 2010 CL Albuquerque, NM SP Amer Assoc Phys Anthropol C1 [Usher, Bethany M.; Casey, Kalen; Echard, Jessica Crandall] SUNY Coll Potsdam, Dept Anthropol, Potsdam, NY 13676 USA. [Usher, Bethany M.] George Mason Univ, Ctr Teaching Excellence, Fairfax, VA 22030 USA. [Casey, Kalen] USA, Cultural Resources Branch, Ft Drum, NY USA. NR 0 TC 0 Z9 0 U1 2 U2 16 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PY 2010 SU 50 BP 232 EP 232 PG 1 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA 565LT UT WOS:000275295200798 ER PT J AU Sondheimer, RM Green, DP AF Sondheimer, Rachel Milstein Green, Donald P. TI Using Experiments to Estimate the Effects of Education on Voter Turnout SO AMERICAN JOURNAL OF POLITICAL SCIENCE LA English DT Article ID CLASS SIZE; UNITED-STATES; EARLY GRADES; PARTICIPATION; ATTITUDES; DESEGREGATION; ELECTIONS; ECONOMICS; DECLINE; SCHOOL AB The powerful relationship between education and voter turnout is arguably the most well-documented and robust finding in American survey research. Yet the causal interpretation of this relationship remains controversial, with many authors suggesting that the apparent link between education and turnout is spurious. In contrast to previous work, which has relied on observational data to assess the effect of education on voter turnout, this article analyzes two randomized experiments and one quasi-experiment in which educational attainment was altered exogenously. We track the children in these experiments over the long term, examining their voting rates as adults. In all three studies, we find that exogenously induced changes in high school graduation rates have powerful effects on voter turnout rates. These results imply that the correlation between education and turnout is indeed causal. We discuss some of the pathways by which education may transmit its influence. C1 [Sondheimer, Rachel Milstein] US Mil Acad, Dept Social Sci, West Point, NY 10996 USA. [Green, Donald P.] Yale Univ, Inst Social & Policy Studies, New Haven, CT 06520 USA. RP Sondheimer, RM (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd, West Point, NY 10996 USA. EM Rachel.Sondheimer@usma.edu; Donald.Green@yale.edu RI Green, Donald/E-4565-2010 OI Green, Donald/0000-0002-8850-438X NR 81 TC 36 Z9 37 U1 2 U2 34 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0092-5853 EI 1540-5907 J9 AM J POLIT SCI JI Am. J. Polit. Sci. PD JAN PY 2010 VL 54 IS 1 BP 174 EP 189 PG 16 WC Political Science SC Government & Law GA 538CM UT WOS:000273161800012 ER PT J AU Angello, JJ Smith, JW AF Angello, Joseph J. Smith, Jack W. TI The Military Accident and Injury Prevention Challenge Setting a Foundation for the Future SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Editorial Material C1 [Angello, Joseph J.] Off Secretary Def Personnel & Readiness, Washington, DC USA. [Smith, Jack W.] Off Assistant Secretary Def Hlth Affairs, Falls Church, VA USA. RP Angello, JJ (reprint author), Care Of Michelle Canham Chervak, USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, E5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM michelle.chervak@us.army.mil NR 24 TC 3 Z9 3 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S212 EP S213 DI 10.1016/j.amepre.2009.10.019 PG 2 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900021 PM 20117595 ER PT J AU Bratt, GM Kluchinsky, TA Coady, P Jordan, NN Jones, BH Spencer, CO AF Bratt, Gary M. Kluchinsky, Timothy A., Jr. Coady, Patrick Jordan, Nikki N. Jones, Bruce H. Spencer, Clark O. TI The Army Health Hazard Assessment Program's Medical Cost-Avoidance Model SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article AB Background: The Logistics Management Institute initially developed a medical cost-avoidance model (MCAM) to estimate the costs associated with the failure to eliminate or control health hazards of army materiel systems during 1997. Methods: Presented is an updated version of the MCAM that uses cost factors for individual health hazard categories. The earlier MCAM calculated army materiel acquisition-life cycle medical costs based on a single cost factor for all hazard categories. Results: The Army's Health Hazard Assessment (HHA) Program, which uses the MCAM while assessing 18 types of health hazards commonly found in materiel undergoing the acquisition process, recognized the need to refine the MCAM to be hazard-type specific. These hazard types have unique cost factors and serve as the basis for the revised model. Conclusions: The revision will assist the HHA program in targeting health hazards that have the potential to affect soldier health and readiness. (Am J Prev Med 2010;38(1S):S34-S41) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Bratt, Gary M.; Coady, Patrick; Spencer, Clark O.] Logist Management Inst, Belcamp, MD USA. [Kluchinsky, Timothy A., Jr.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Kluchinsky, Timothy A., Jr.; Jordan, Nikki N.; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Coady, Patrick] Success All Fdn, Baltimore, MD USA. RP Kluchinsky, TA (reprint author), USA, Ctr Hlth Promot & Prevent Med, 5158 Blackhawk Rd, Aberdeen, MD 21010 USA. EM timothy.kluchinsky@us.army.mil NR 33 TC 5 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S34 EP S41 DI 10.1016/j.amepre.2009.10.002 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900004 PM 20117599 ER PT J AU Bullock, SH Jones, BH Gilchrist, J Marshall, SW AF Bullock, Steven H. Jones, Bruce H. Gilchrist, Julie Marshall, Stephen W. TI Prevention of Physical Training-Related Injuries Recommendations for the Military and Other Active Populations Based on Expedited Systematic Reviews SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Review ID ANTERIOR CRUCIATE LIGAMENT; HYDROXY-BETA-METHYLBUTYRATE; OF-THE-LITERATURE; RANDOMIZED CONTROLLED-TRIAL; AUSTRALIAN ARMY RECRUITS; LOWER-EXTREMITY INJURIES; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CARBOHYDRATE-PROTEIN SUPPLEMENT; EXERCISE-RELATED INJURIES; LIMB MUSCLE SYNCHRONY AB Background: The Military Training Task Force of the Defense Safety Oversight Council chartered a joint Services Physical Training Injury Prevention Working Group to: (1) establish the evidence base for making recommendations to prevent injuries; (2) prioritize the recommendations for prevention programs and policies; and (3) substantiate the need for further research and evaluation on interventions and programs likely to reduce physical training-related injuries. Evidence acquisition: A work group was formed to identify, evaluate, and assess the level of scientific evidence for various physical training-related injury prevention strategies through an expedited systematic review process. Of 40 physical training-related injury prevention strategies identified, education, leader support, and surveillance were determined to be essential elements of a successful injury prevention program and not independent interventions. As a result of the expedited systematic reviews, one more essential element (research) was added for a total of four. Six strategies were not reviewed. The remaining 31 interventions were categorized into three levels representing the strength of recommendation: (1) recommended; (2) not recommended; and (3) insufficient evidence to recommend or not recommend. Evidence synthesis: Education, leadership support, injury surveillance, and research were determined to be critical components of any successful injury prevention program. Six interventions (i.e., prevent overtraining, agility-like training, mouthguards, semirigid ankle braces, nutrient replacement, and synthetic socks) had strong enough evidence to become working group recommendations for implementation in the military services. Two interventions (i.e., back braces and pre-exercise administration of anti-inflammatory medication) were not recommended due to evidence of ineffectiveness or harm, 23 lacked sufficient scientific evidence to support recommendations for all military services at this time, and six were not evaluated. Conclusions: Six interventions should be implemented in all four military services immediately to reduce physical training-related injuries. Two strategies should be discouraged by all leaders at all levels. Of particular note, 23 popular physical training-related injury prevention strategies need further scientific investigation, review, and group consensus before they can be recommended to the military services or similar civilian populations. The expedited systematic process of evaluating interventions enabled the working group to bad consensus around those injury prevention strategies that had enough scientific evidence to support a recommendation. (Am J Prev Med 20 10;38(1S):S156-S181) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Bullock, Steven H.] USA, Ctr Hlth Promot & Prevent Med, Publ Hlth Assessment Program, Aberdeen Proving Ground, MD USA. [Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD USA. [Gilchrist, Julie] Ctr Dis Control & Prevent, Div Unintent Injury Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. [Marshall, Stephen W.] Univ N Carolina, Injury Prevent Res Ctr, Dept Epidemiol Biostat Core, Chapel Hill, NC USA. RP Bullock, SH (reprint author), 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM Steven.H.Bullock@us.army.mil OI Marshall, Stephen/0000-0002-2664-9233 NR 329 TC 42 Z9 44 U1 1 U2 11 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S156 EP S181 DI 10.1016/j.amepre.2009.10.023 PG 26 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900017 PM 20117590 ER PT J AU Burnham, BR Copley, GB Shim, MJ Kemp, PA Jones, BH AF Burnham, Bruce R. Copley, G. Bruce Shim, Matthew J. Kemp, Philip A. Jones, Bruce H. TI Mechanisms of Flag-Football Injuries Reported to the HQ Air Force Safety Center A 10-Year Descriptive Study, 1993-2002 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID UNITED-STATES; SPORTS; EPIDEMIOLOGY AB Background: Flag (touch or intramural) football is a popular sport among the U.S. Air Force (USAF) active duty population and causes a substantial number of lost-workday injuries. The purpose of this study is to describe the mechanisms of flag-football injuries to better identify effective countermeasures. Methods: The data were derived from safety reports obtained from the USAF Ground Safety Automated System. Flag-football injuries for the years 1993-2002 that resulted in at least one lost workday were included in the study conducted in 2003. Narrative data were systematically reviewed for 32,812 USAF mishap reports; these were then coded in order to categorize and summarize mechanisms associated with flag football and other sports and occupational injuries. Results: Nine hundred and forty-four mishap reports involving active duty USAF members playing flag football met the criteria for inclusion into this study. Eight mechanisms of injury were identified. The eight mechanisms accounted for 90% of all flag-football injuries. One scenario (contact with another player) accounted for 42% of all flag-football injuries. Conclusions: The most common mechanisms of injury caused by playing flag football can be identified using the detailed information found in safety reports. These scenarios are essential to developing evidence-based countermeasures. Results for flag football suggest that interventions that prevent player contact injuries deserve further research and evaluation. The broader implications of this study are that military safety data can be used to identify potentially modifiable mechanisms of injury for specific activities such as flag football. (Am J Prev Med 2010;38(1S):S141-S147) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Burnham, Bruce R.; Kemp, Philip A.] AFSC, Anal & Integrat Div, Kirtland AFB, NM USA. [Copley, G. Bruce] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Shim, Matthew J.] USAF, Inst Operat Hlth, San Antonio, TX USA. [Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD USA. RP Burnham, BR (reprint author), USAF, HQ, Safety Ctr, SEAR, 9700 G Ave SE, Kirtland AFB, NM 87117 USA. EM bruce.burnham@kirtland.af.mil FU AFSC FX We gratefully acknowledge all the members of the Research and Epidemiology Branch who participated in this project. DJ Atkins,Tom Schultz, and Donna Roper all provided invaluable support in data abstraction and guidance in this project. The work was entirely funded by the AFSC. NR 18 TC 9 Z9 9 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S141 EP S147 DI 10.1016/j.amepre.2009.10.010 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900015 PM 20117588 ER PT J AU Burnham, BR Copley, GB Shim, MJ Kemp, PA Jones, BH AF Burnham, Bruce R. Copley, G. Bruce Shim, Matthew J. Kemp, Philip A. Jones, Bruce H. TI Mechanisms of Slow-Pitch Softball Injuries Reported to the HQ Air Force Safety Center A 10-Year Descriptive Study, 1993-2002 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID PREVENTION; BASEBALL; PLAYERS; SPORTS; ARMY; BALL AB Background: Softball is a popular sport in civilian and military populations and results in a large number of lost-workday injuries. The purpose of this study is to describe the mechanisms associated with softball injuries occurring among active duty U.S. Air Force (USAF) personnel to better identify potentially effective countermeasures. Methods: Data derived from safety reports were obtained from the USAF Ground Safety Automated System in 2003. Softball injuries for the years 1993-2002 that resulted in at least one lost workday were included in the study. Narrative data were systematically reviewed and coded in order to categorize and summarize mechanisms associated with these injuries. Results: This report documents a total of 1181 softball-related mishap reports, involving 1171 active duty USAF members who sustained one lost-workday injury while playing softball. Eight independent mechanisms were identified. Three specific scenarios (sliding, being hit by a ball, and colliding with a player) accounted for 60% of reported softball injuries. Conclusions: Mechanisms of injury for activities such as playing softball, necessary for prevention planning, can be identified using the detailed information found in safety reports. This information should also be used to develop better sports injury coding systems. Within the USAF and U.S. softball community, interventions to reduce injuries related to the most common mechanisms (sliding, being hit by a ball, and colliding with a player) should be developed, implemented, and evaluated. (Am J Prev Med 2010;38(1S):S126-S133) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Burnham, Bruce R.; Kemp, Philip A.] USAF, Safety Ctr, Anal & Integrat Div, Kirtland AFB, NM USA. [Copley, G. Bruce] ExxonMobil Biomed Sci Inc, Annandale, NJ USA. [Shim, Matthew J.] USAF, Inst Operat Hlth, San Antonio, TX USA. [Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD USA. RP Burnham, BR (reprint author), HQ AFSC SEPR, 9700 G Ave SE, Kirtland AFB, NM 87117 USA. EM bruce.burnham@kirtland.af.mil NR 24 TC 9 Z9 9 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S126 EP S133 DI 10.1016/j.amepre.2009.10.008 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900013 PM 20117586 ER PT J AU Canham-Chervak, M Hooper, TI Brennan, FH Craig, SC Girasek, DC Schaefer, RA Barbour, G Yew, KS Jones, BH AF Canham-Chervak, Michelle Hooper, Tomoko I. Brennan, Fred H., Jr. Craig, Stephen C. Girasek, Deborah C. Schaefer, Richard A. Barbour, Galen Yew, Kenneth S. Jones, Bruce H. TI A Systematic Process to Prioritize Prevention Activities Sustaining Progress Toward the Reduction of Military Injuries SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID CENTERS; TOPICS AB Background: To sustain progress toward injury reduction and other health promotion goals, public health organizations need a systematic approach based on data and an evaluation of existing scientific evidence on prevention. This paper describes a process and criteria developed to systematically and objectively define prevention program and policy priorities. Methods: Military medical surveillance data were obtained and summarized, and a working group of epidemiology and injury experts was formed. After reviewing the available data, the working group used predefined criteria to score leading military unintentional injury causes on five main criteria that assessed factors contributing to program and policy success: (1) importance of the problem, (2) effectiveness of existing prevention strategies, (3) feasibility of establishing programs and policies, (4) timeliness of implementation and results, and (5) potential for evaluation. Injury problems were ranked by total median score. Results: Causes with the highest total median scores were physical training (34 points), military parachuting (32 points), privately-owned vehicle crashes (31 points), sports (29 points), falls (27 points), and military vehicle crashes (27 points). Conclusions: Using a data-driven, criteria-based process, three injury causes (physical training, military parachuting, and privately owned-vehicle crashes) with the greatest potential for successful program and policy implementation were identified. Such information is useful for public health practitioners and policymakers who must prioritize among health problems that are competing for limited resources. The process and criteria could be adapted to systematically assess and prioritize health issues affecting other communities. (Am J Prev Med 2010;38(1S):S11-S18) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Canham-Chervak, Michelle] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. [Hooper, Tomoko I.; Girasek, Deborah C.; Barbour, Galen] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Craig, Stephen C.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Schaefer, Richard A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. [Yew, Kenneth S.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA. [Brennan, Fred H., Jr.] Seacoast Orthoped & Sports Med, Somersworth, NH USA. RP Canham-Chervak, M (reprint author), USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. EM michelle.chervak@us.army.mil NR 58 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S11 EP S18 DI 10.1016/j.amepre.2009.10.003 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900002 PM 20117584 ER PT J AU Hauret, KG Jones, BH Bullock, SH Canham-Chervak, M Canada, S AF Hauret, Keith G. Jones, Bruce H. Bullock, Steven H. Canham-Chervak, Michelle Canada, Sara TI Musculoskeletal Injuries Description of an Under-Recognized Injury Problem Among Military Personnel SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID CUMULATIVE TRAUMA DISORDERS; DATA-COLLECTION PROCEDURES; EXERCISE-RELATED INJURIES; WORKPLACE RISK-FACTORS; SURVEILLANCE SYSTEM; UPPER-LIMB; PSYCHOPHYSICAL RESEARCH; BASKETBALL INJURIES; CONSENSUS STATEMENT; INFANTRY SOLDIERS AB Introduction: Although injuries are recognized as a leading health problem in the military, the size of the problem is underestimated when only acute traumatic injuries are considered. Injury-related musculoskeletal conditions are common in this young, active Population. Many of these involve physical damage caused by micro-trauma (overuse) in recreation, sports, training, and job performance. The purpose of this analysis was to determine the incidence of injury-related musculoskeletal conditions in the military services (2006) and describe a standardized format in which to categorize and report them. Methods: The Subset of musculoskeletal diagnoses found to be injury-related in previous military investigations was identified. Musculoskeletal injuries among nondeployed, active duty service members in 2006 were identified from military medical surveillance data. A matrix was used to report and categorize these conditions by injury type and body region. Results: There were 743,547 injury-related musculoskeletal conditions in 2006 (Outpatient and inpatient, combined), including primary and nonprimary diagnoses. In the matrix, 82% of injury-related musculoskeletal conditions were classified as inflammation/pain (overuse), followed by joint derangements (15%) and stress fractures (2%). The knee/lower leg (22%), lumbar spine (20%), and ankle/foot (13%) were leading body region categories. Conclusions: When assessing the magnitude of the injury problem in the military services, injury-related musculoskeletal conditions should be included. When these injuries are combined with acute traumatic injuries, there are almost 1.6 million injury-related medical encounters each year. The matrix provides a standardized format to categorize these injuries, make comparisons over time, and focus prevention efforts on leading injury types and/or body regions. (Am J Prev Med 2010;38(1S):S61-S70) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Hauret, Keith G.; Jones, Bruce H.; Canham-Chervak, Michelle; Canada, Sara] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD USA. RP Hauret, KG (reprint author), USACHPPM ATTN MCHB TS DI, 5158 Blackhawk Rd,Bldg 4435, Aberdeen Proving Ground, MD 21010 USA. EM keith.hauret@us.army.mil NR 82 TC 56 Z9 60 U1 1 U2 15 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S61 EP S70 DI 10.1016/j.amepre.2009.10.021 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900006 PM 20117601 ER PT J AU Hauret, KG Taylor, BJ Clemmons, NS Block, SR Jones, BH AF Hauret, Keith G. Taylor, Bonnie J. Clemmons, Nakia S. Block, Suzanne R. Jones, Bruce H. TI Frequency and Causes of Nonbattle Injuries Air Evacuated from Operations Iraqi Freedom and Enduring Freedom, US Army, 2001-2006 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID UNITED-STATES; DESERT-SHIELD; DISEASE; VIETNAM; BOSNIA; REGION; SPORTS; STORM AB Introduction: Medical information systems during past military deployments had limited injury surveillance capability as data were not accessible during deployments and did not capture causes of injury. This paper describes nonbattle injury (NBI) results from an ongoing surveillance program that identifies injury occurrences and causes during deployments for Operations Iraqi Freedom (Iraq) and Enduring Freedom (Afghanistan). Methods: U.S. Army soldiers medically air evacuated from Iraq (March 2003-December 2006) or Afghanistan (October 2001-December 2006) were identified from air evacuation records that provided demographics, casualty type, diagnosis, and patient history. For NBI cases, the patient history was used to identify and code injury cause, incident circumstances, and body region. Descriptive statistics were used to describe and compare NBIs evacuated from Iraq and Afghanistan. Results: In all, 27,563 soldiers in Iraq and 4165 in Afghanistan were air evacuated. NBIs accounted for 35% and 36% of cases, respectively, and were the largest single category of evacuations for both operations. Distributions for leading categories of NBI diagnosis (fracture, inflammation/pain, and dislocation) and body region (back, knee, and wrist/hand) were similar for both operations. Leading NBI causes were the same for both operations-sports/physical training (19%-21%), falls/jumps (18%), and motor vehicle-related incidents (12%-16%)-but the proportion of motor vehicle incidents was higher in Iraq (p<0.001). Conclusions: Routinely collected air evacuation records provided the basis for ongoing injury surveillance for Iraq and Afghanistan. NBI was the largest category of evacuations from both operations. Leading NBI causes were similar to those identified for previous deployments and many should be preventable. (Am J Prev Med 2010;38(1S):S94-S107) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Hauret, Keith G.; Taylor, Bonnie J.; Clemmons, Nakia S.; Block, Suzanne R.; Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD USA. RP Hauret, KG (reprint author), USACHPPM ATTN MCHB TS DI, 5158 Blackhawk Rd,Bldg 4435, Aberdeen Proving Ground, MD 21010 USA. EM keith.hauret@us.army.mil NR 31 TC 36 Z9 37 U1 0 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S94 EP S107 DI 10.1016/j.amepre.2009.10.022 PG 14 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900010 PM 20117605 ER PT J AU Helfer, TM Canham-Chervak, M Canada, S Mitchener, TA AF Helfer, Thomas M. Canham-Chervak, Michelle Canada, Sara Mitchener, Timothy A. TI Epidemiology of Hearing Impairment and Noise-Induced Hearing Injury Among US Military Personnel, 2003-2005 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID UNITED-STATES; HEALTH AB Introduction: Rates of noise-induced hearing injury (NIHI) among U.S. active duty military have not been previously described using available military medical surveillance data. Methods: NIHI were identified in the Defense Medical Surveillance System (DMSS) using a list of ICD-9-CM diagnosis codes selected in collaboration with military audiologists. To provide a more comprehensive view of the NIHI problem, NIHI-related ICD-9 codes beyond the traditional 388 noise injury-code set were included. Visit rates by gender and age group are reported by quarter, 2003-2005. Overall frequencies and rates by occupational specialty, 2003-2005, are also described. Results: From 2003 to 2005, rates for men were significantly higher than rates for women, with rate ratios (RR) ranging from 1.15 (95% CI = 1.07, 1.23) to 1.78 (95% CI = 1.62, 1.93). Rates among women ranged from 2.9 to 6.2 per 1000 person-years; rates among men ranged from 4.5 to 6.7 per 1000 person-years. NIHI rates were highest among those aged >= 40 years and lowest among those aged 17-19 years, with RRs ranging from 3.06 (95% CI = 2.77, 3.40) to 5.51 (95% CI = 4.88, 6.30) during this time period. Among occupational groups, general officers/executives had the highest NIHI rate over this time period (29.5/1000 person-years), followed by enlisted personnel in training (14.3/1000 person-years) and scientists and professionals (12.8/1000 person-years). Conclusions: While data on outpatient injury causes and use of hearing protection are also needed to guide the future design and/or modification of interventions, existing military medical surveillance provides essential information for tracking NIHI and monitoring NIHI intervention effects. (Am J Prev Med 2010;38(1S):S71-S77) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Helfer, Thomas M.] USA, Ctr Hlth Promot & Prevent Med, Army Hearing Program, Aberdeen Proving Ground, MD 21010 USA. RP Helfer, TM (reprint author), USA, Ctr Hlth Promot & Prevent Med, Army Hearing Program, Aberdeen Proving Ground, MD 21010 USA. EM Thomas.Helfer@us.army.mil NR 26 TC 13 Z9 13 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 SU 1 BP S71 EP S77 DI 10.1016/j.amepre.2009.10.025 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900007 PM 20117602 ER PT J AU Hilber, D Mitchener, TA Stout, J Hatch, B Canham-Chervak, M AF Hilber, David Mitchener, Timothy A. Stout, James Hatch, Brian Canham-Chervak, Michelle TI Eye Injury Surveillance in the US Department of Defense, 1996-2005 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID UNITED-STATES AB Background: Consistent with the public health approach to prevention, surveillance analyses are needed to fully understand a health problem. U.S. military eye injury rates have not been fully described using medical surveillance data. Methods: Medical visit data on active duty personnel, 1996-2005, and causes of eye injury hospitalizations (identified by Standard NATO Agreement injury cause codes) were obtained from the Defense Medical Surveillance System. Eye injury-related ICD-9-CM codes beyond the traditional 800-999 injury code set were included. Rates by age and gender are reported for 1996-2005, along with the frequency of causes of injury hospitalizations and leading eye injury diagnoses for 2005. Results: Eye injury rates among active duty military personnel increased from 1996 to 2005 among both men and women (p<0.001), with the highest rates in 2004 (26/1000 person-years and 21/1000 person-years, women and men, respectively). Women consistently had 7%-21% higher rates than men (rate ratios=1.07; 95% CI=1.04, 1.11) to 1.21 (95% CI=1.17,1.25). From 1996-2005, eye injury rates increased among all age groups (p<0.001). From 2002-2005, rates were highest for those aged >= 40 years compared to those aged 17-19 years (rate ratios=1.17 [95% CI=1.11, 1.24] to 1.24 [95% CI=1.18, 1.31]). Leading causes of eye injury hospitalizations were ordnance handling (16.9%), enemy action (13.1%), and fighting (11.9%). Conclusions: Medical surveillance data enable the assessment and monitoring of overall active duty eye injury rates, trends, and causes. Outpatient data could be improved with the addition of cause of injury codes and eye protection use. Current data suggest that continued use of eye protection during ordnance handling, combat, motor vehicle use, and sports could help reduce eye injury rates. (Am J Prev Med 2010;38(1S):S78-S85) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Hilber, David] USA, Ctr Hlth Promot & Prevent Med, ATTN MCHB TS MTS, Directorate Epidemiol & Dis Prevent, Aberdeen Proving Ground, MD 21010 USA. [Canham-Chervak, Michelle] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD 21010 USA. [Hilber, David; Stout, James; Hatch, Brian] USA, Ctr Hlth Promot & Prevent Med, Directorate Occupat & Environm Med, Triserv Vis Conservat & Readiness Program, Aberdeen Proving Ground, MD 21010 USA. RP Hilber, D (reprint author), USA, Ctr Hlth Promot & Prevent Med, ATTN MCHB TS MTS, Directorate Epidemiol & Dis Prevent, Aberdeen Proving Ground, MD 21010 USA. EM david.hilber@us.army.mil; michelle.chervak@us.army.mil NR 12 TC 7 Z9 9 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S78 EP S85 DI 10.1016/j.amepre.2009.10.015 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900008 PM 20117603 ER PT J AU Jones, BH Canham-Chervak, M Canada, S Mitchener, TA Moore, S AF Jones, Bruce H. Canham-Chervak, Michelle Canada, Sara Mitchener, Timothy A. Moore, Sean TI Medical Surveillance of Injuries in the US Military Descriptive Epidemiology and Recommendations for Improvement SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID PUBLIC-HEALTH SURVEILLANCE; UNITED-STATES; SYSTEM AB Introduction: Injury surveillance is the first and most critical step of the injury prevention process. Without it, successful injury prevention could not be sustained. The purpose of this paper is to describe advances in military medical surveillance, compare the incidence of injuries with other illnesses, define the size and causes of the injury problem for the military, and make recommendations for improved surveillance and injury prevention. Methods: Medical and personnel data for nondeployed active duty personnel were obtained from the Armed Forces Health Surveillance Center for 2000-2006. Rates of nonfatal injuries and injury-related musculoskeletal conditions, frequencies of injury types, and causes of injury hospitalizations are described. Results: injuries were the leading cause of medical encounters among military personnel. The rate of hospitalization for injuries was approximately 1000 per 100,000 person-years and, for injuries treated in outpatient clinics, 999 per 1000 person-years. The leading injury type resulting in hospitalization was fractures (40%) and the leading injury type resulting in outpatient visits was sprains and strains (49%). Leading causes of hospitalization were falls/near falls (17.5%), motor vehicle mishaps (15.4%), and sports (13.1%). Conclusions: Injuries are the biggest health problem of the military services. Military medical surveillance data are useful for determining the magnitude and causes of the injury problem, identifying possible prevention targets, and monitoring of trends among military personnel. (Am J Prev Med 2010;38(1S):S42-S60) Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine C1 [Jones, Bruce H.] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. [Mitchener, Timothy A.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. [Moore, Sean] Armed Forces Hlth Surveillance Ctr, Washington, DC USA. RP Jones, BH (reprint author), USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. EM bruce.h.jones@us.army.mil NR 40 TC 44 Z9 44 U1 4 U2 9 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S42 EP S60 DI 10.1016/j.amepre.2009.10.014 PG 19 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900005 PM 20117600 ER PT J AU Jones, BH Canham-Chervak, M Sleet, DA AF Jones, Bruce H. Canham-Chervak, Michelle Sleet, David A. TI An Evidence-Based Public Health Approach to Injury Priorities and Prevention Recommendations for the US Military SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Editorial Material ID SERVICES TASK-FORCE; SETTING PRIORITIES; RISK-FACTORS; INTERVENTIONS; SYSTEM; POLICY; CARE AB Injuries are the leading cause of morbidity and mortality confronting U.S. military forces in peacetime or combat operations. Not only are injuries the biggest health problem of the military services, they are also a complex problem. The leading causes of deaths are different from those that result in hospitalization, which are different from those that result in outpatient care. As a consequence, it is not possible to focus on just one level of injury severity if the impact of injuries on military personnel is to be reduced. To effectively reduce the impact of a problem as big and complex as injuries requires a systematic approach. The purpose of this paper is to: (1) review the steps of the public health process for injury prevention; (2) review literature on evaluation of the scientific quality and consistency of information needed to make decisions about prevention policies, programs, and interventions; and (3) summarize criteria for setting objective injury prevention priorities. The review of these topics will serve as a foundation for making recommendations to enhance the effectiveness of injury prevention efforts in the military and similarly large communities. This paper also serves as an introduction to the other articles in this supplement to the American Journal of Preventive Medicine that illustrate the recommended systematic approach. (Aim J Prev Med 20 10;38(1S):S1-S10) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Canham-Chervak, Michelle] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. [Sleet, David A.] Ctr Dis Control & Prevent, Natl Ctr Injury Prevent & Control, Atlanta, GA USA. RP Canham-Chervak, M (reprint author), USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. EM michelle.chervak@us.army.mil NR 56 TC 24 Z9 24 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S1 EP S10 DI 10.1016/j.amepre.2009.10.001 PG 10 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900001 PM 20117582 ER PT J AU Knapik, JJ Brosch, LC Venuto, M Swedler, DI Bullock, SH Gaines, LS Murphy, RJ Tchandja, J Jones, BH AF Knapik, Joseph J. Brosch, Lorie C. Venuto, Margaret Swedler, David I. Bullock, Steven H. Gaines, Lorraine S. Murphy, Ryan J. Tchandja, Juste Jones, Bruce H. TI Effect on Injuries of Assigning Shoes Based on Foot Shape in Air Force Basic Training SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID PHYSICAL-ACTIVITY; RISK-FACTORS; STRESS-FRACTURES; LOWER-EXTREMITY; YOUNG MEN; RUNNING INJURIES; FEMALE RECRUITS; ARMY RECRUITS; US ARMY; FITNESS AB Background: This study examined whether assigning running shoes based on the shape of the bottom of the foot (plantar surface) influenced injury risk in Air Force Basic Military Training (BMT) and examined risk factors for injury in BMT. Methods: Data were collected from BMT recruits during 2007; analysis took place during 2008. After foot examinations, recruits were randomly consigned to either an experimental group (E, n=1042 men, 375 women) or a control group (C, n=913 men, 346 women). Experimental group recruits were assigned motion control, stability, or cushioned shoes for plantar shapes indicative of low, medium, or high arches, respectively. Control group recruits received a stability shoe regardless of plantar shape. Injuries during BMT were determined from Outpatient visits provided from the Defense Medical Surveillance System. Other injury risk factors (fitness, smoking, physical activity, prior injury, menstrual history, and demographics) were obtained from a questionnaire, existing databases, or BMT units. Results: Multivariate Cox regression controlling for other risk factors showed little difference in injury risk between the groups among men (hazard ratio [E/C]= 1.11, 95%CI=0.89-1.38) or women (hazard ratio [E/C] = 1.20, 95% CI=0.90-1.60). Independent injury risk factors among both men and women included low aerobic fitness and cigarette smoking. Conclusions: This prospective study demonstrated that assigning running shoes based on the shape of the plantar Surface had little influence on injury risk in BMT even after controlling for other injury risk factors. (Am J Prev Med 2010;38(1S):S197-S211) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Knapik, Joseph J.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. [Venuto, Margaret] US FDA, Dept Hlth & Human Serv, College Pk, MD USA. [Brosch, Lorie C.; Tchandja, Juste] USAF, Med Grp 37, Lackland AFB, TX USA. [Murphy, Ryan J.] USA, Med Dept Ctr & Sch, Ft Sam Houston, TX USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, 1570 Stark Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@us.army.mil NR 64 TC 35 Z9 35 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S197 EP S211 DI 10.1016/j.amepre.2009.10.013 PG 15 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900020 PM 20117594 ER PT J AU Knapik, JJ Spiess, A Swedler, DI Grier, TL Darakjy, SS Jones, BH AF Knapik, Joseph J. Spiess, Anita Swedler, David I. Grier, Tyson L. Darakjy, Salima S. Jones, Bruce H. TI Systematic Review of the Parachute Ankle Brace Injury Risk Reduction and Cost Effectiveness SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Review ID SPRAINS; FEMALE; IMPACT; JUMPS AB Introduction: Military parachuting has been shown to result in injuries. This investigation systematically reviewed studies examining the influence of the parachute ankle brace (PAB) on injuries during military parachuting and performed a cost-effectiveness analysis. Evidence acquisition: Parachute ankle brace studies were obtained from seven databases, personal contacts, and other sources. Investigations were reviewed if they contained original, quantitative information on PAB use and injuries during parachuting. Meta-analysis was performed using a general variance-based meta-analysis method that calculated summary risk ratios (SRR) and 95% CIs. Evidence synthesis: Five studies met the review criteria. Compared with PAB users, PAB non-users had a higher risk of ankle injuries (SRR=2.1, 95% CI=1.8-2.5); ankle sprains (SRR=2.1, 95% CI=1.4-3.1); ankle fractures (SRR=1.8, 95% CI=1.1-2.9); and all parachuting injuries combined (SRR=1.2, 95% CI=1.1-1.4). The PAB had little effect on lower body injuries exclusive of the ankle (SRR [no PAB/PAB]=0.9, 95% CI=0.7-1.2). Cost-effectiveness analysis estimated that, for every dollar expended on the PAB, a savings of about $7 to $9 could be achieved in medical and personnel costs. Conclusions: The PAB reduces ankle injuries by about half and is a cost effective device that should be worn during military airborne operations to reduce injury risk. (Am J Prev Med 2010;38(1S):S182-S188) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Knapik, Joseph J.] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Injury Prevent Program,ATTN MCHB TS DI, Aberdeen Proving Ground, MD 21010 USA. RP Knapik, JJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Injury Prevent Program,ATTN MCHB TS DI, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM joseph.knapik@apg.amedd.army.mil NR 24 TC 10 Z9 14 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S182 EP S188 DI 10.1016/j.amepre.2009.10.012 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900018 PM 20117591 ER PT J AU Mitchener, TA Canham-Chervak, M AF Mitchener, Timothy A. Canham-Chervak, Michelle TI Oral-Maxillofacial Injury Surveillance in the Department of Defense, 1996-2005 SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID UNITED-STATES; PREVENTION; ARMY; MOUTHGUARDS; SPORT AB Introduction: Oral-maxillofacial injuries can lead to deformity and malfunction, greatly diminishing quality of life and worker productivity. Data suggest that over 10% of civilian emergency room visits are due to craniofacial injuries. The size and scope of oral-maxillofacial injuries in the military is not well understood. This study reports U.S. military rates of oral-maxillofacial injuries, causes of oral-maxillofacial hospitalizations, and recommends approaches to improving surveillance, research, and prevention. Methods: Active duty U.S. military personnel who sought inpatient or outpatient treatment for one or more oral-maxillofacial injuries from 1996 to 2005 were identified in the Defense Medical Surveillance System using ICD-9-CM diagnosis codes associated with oral-maxillofacial injuries. ICD-9-CM diagnosis codes were divided into two categories: oral-maxillofacial wounds and oral-maxillofacial fractures. Results: The oral-maxillofacial fracture rates for men were consistently 1.5 to 2 times higher than those for women, with 2000-2005 rates between 1.2 and 1.5/1000 person-years for men and between 0.7 and 1.0/1000 person-years for women. Wound rates for men were similar to those for women for all years examined (p<0.001), with 2000-2005 rates ranging from 11.0 to 14.6/1000 person-years for men and 12.2-14.8/1000 person-years for women. Compared to the over-40 age group, active duty personnel under age 25 had the highest rates of both oral-maxillofacial fractures and wounds (p<0.001). Among those injuries with a cause recorded, fighting (1w3.5%) was the leading cause of oral-maxillofacial injury hospitalizations in 2005. Conclusions: Oral-maxillofacial injuries can and should be monitored using military medical surveillance data. Surveillance efforts would be enhanced by the addition of dental care data. There is also a need for additional quality intervention studies on the strategies to prevent oral and craniofacial injury. (Am J Prev Med 2010;38(1S):S86-S93) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Mitchener, Timothy A.; Canham-Chervak, Michelle] USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. RP Mitchener, TA (reprint author), USA, Ctr Hlth Promot & Prevent Med, Directorate Epidemiol & Dis Surveillance, Aberdeen Proving Ground, MD 21010 USA. EM Timothy.Mitchener@us.army.mil NR 24 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S86 EP S93 DI 10.1016/j.amepre.2009.10.016 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900009 PM 20117604 ER PT J AU Ruscio, BA Jones, BH Bullock, SH Burnham, BR Canham-Chervak, M Rennix, CP Wells, TS Smith, JW AF Ruscio, Bruce A. Jones, Bruce H. Bullock, Steven H. Burnham, Bruce R. Canham-Chervak, Michelle Rennix, Christopher P. Wells, Timothy S. Smith, Jack W. TI A Process to Identify Military Injury Prevention Priorities Based on Injury Type and Limited Duty Days SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article AB Background: Injuries, one of the leading public health problems in an otherwise healthy military population, affect operational readiness, increase healthcare costs, and result in disabilities and fatalities. This paper describes a systematic, data-driven, injury prevention-decision making process to rank potential injury prevention targets. Methods: Medical surveillance and safety report data on injuries for 2004 were reviewed. Nonfatal injury diagnoses (ICD-9-CM codes) obtained from the Defense Medical Surveillance System were ranked according to incident visit frequency and estimated limited duty days. Data on the top five injury types resulting in the greatest estimated limited duty days were matched with hospitalization and Service Safety Centers' accident investigation data to identify leading causes. Experts scored and ranked the causes using predetermined criteria that considered the importance of the problem, preventability, feasibility, timeliness of intervention establishment/results, and ability to evaluate. Department of Defense (DoD) and Service-specific injury prevention priorities were identified. Results: Unintentional injuries lead all other medical conditions for number of medical encounters, individuals affected, and hospital bed days. The top ten injuries resulted in an estimated 25 million days of limited duty. Injury-related musculoskeletal conditions were a leading contributor to days of limited duty. Sports and physical training were the leading cause, followed by falls. Conclusions: A systematic approach to injury prevention-decision making supports the DoD's goal of ensuring a healthy, fit force. The methodology described here advances this capability. Immediate follow-up efforts should employ both medical and safety data sets to identify and monitor injury prevention priorities. (Am J PrevMed 2010;38 (1S):S19-S33) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Ruscio, Bruce A.] Novartis Vaccines & Diagnost, Washington, DC USA. [Jones, Bruce H.; Canham-Chervak, Michelle] USA, Ctr Hlth Promot & Prevent Med, Injury Prevent Program, Aberdeen Proving Ground, MD USA. [Bullock, Steven H.] Hlth Promot Policy Program, Aberdeen Proving Ground, MD USA. [Burnham, Bruce R.] USAF, Safety Ctr, Res & Epidemiol Branch, Kirtland AFB, NM USA. [Rennix, Christopher P.] Navy & Marine Corps Publ Hlth Ctr, EpiData Ctr, Portsmouth, Hants, England. [Smith, Jack W.] Off Assistant Secretary Def Hlth Affairs, Clin & Program Policy, Falls Church, VA USA. [Wells, Timothy S.] USAF, Res Lab, Biomech Branch, Wright Patterson AFB, OH 45433 USA. RP Ruscio, BA (reprint author), 701 Penn Ave NW,Suite 725, Washington, DC 20004 USA. EM Bruce.ruscio@novartis.com NR 32 TC 39 Z9 39 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 BP S19 EP S33 DI 10.1016/j.amepre.2009.10.004 PG 15 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900003 PM 20117593 ER PT J AU Wojcik, BE Stein, CR Bagg, K Humphrey, RJ Orosco, J AF Wojcik, Barbara E. Stein, Catherine R. Bagg, Karen Humphrey, Rebecca J. Orosco, Jason TI Traumatic Brain Injury Hospitalizations of US Army Soldiers Deployed to Afghanistan and Iraq SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article ID WARS AB Background: Traumatic brain injury (TBI) is a life-altering condition that has affected many of our soldiers returning from war. In the current conflicts, the improvised explosive device (IED) has greatly increased the potential for soldiers to sustain a TBI. This study's objective was to establish benchmark admission rates for U.S. Army soldiers with TBIs identified during deployment to Iraq and Afghanistan. Methods: The study population consisted of U.S. Army soldiers deployed to Iraq and Afghanistan from September 11, 2001, through September 30,2007. Population data were merged with admission data to identify hospitalizations during deployment. Using the international Barell Injury Diagnosis Matrix, TBI-related admissions were categorized into Type 1 (the most severe), Type 2, and Type 3 (the least severe). All analyses were performed in 2008. Results: Of the 2898 identified TBI inpatient episodes of care, 46% were Type 1, 54% were Type 2, and less than 1% were Type 3. Over-65% of Type 1 injuries resulted from explosions, while almost half of all TBIs were non-battle-related. Overall TBI admission rates were 24.6 for Afghanistan and 41.8 for Iraq per 10,000 soldier-years. TBI hospitalization rates rose over time for both campaigns, although U.S. Army soldiers in Iraq experienced 1.7 times higher rates overall and 2.2 times higher Type 1 admission rates than soldiers in Afghanistan. The TBI-related proportion of all injury hospitalizations showed an ascending trend. Conclusions: Future surveillance of TBI hospitalization rates is needed to evaluate the effectiveness of implementation of preventive measures. (Am J Prev Med 2010;38(1S):S108 -S116) Published by Elsevier Inc. on behalf of American journal of Preventive Medicine C1 [Wojcik, Barbara E.; Stein, Catherine R.; Bagg, Karen; Humphrey, Rebecca J.] USA, Med Dept Ctr & Sch, Ctr Army, Med Dept Strateg Studies, Ft Sam Houston, TX USA. [Orosco, Jason] Lockheed Martin Corp, Bethesda, MD USA. RP Wojcik, BE (reprint author), CASS, 1608 Stanley Rd,Suite 47, Ft Sam Houston, TX 78234 USA. EM barbara.wojcik@amedd.army.mil NR 24 TC 49 Z9 51 U1 1 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD JAN PY 2010 VL 38 IS 1 SU 1 BP S108 EP S116 DI 10.1016/j.amepre.2009.10.006 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA 541KM UT WOS:000273413900011 PM 20117583 ER PT J AU Greer, J Holley, AB Collen, J Shah, A Lettieri, C AF Greer, J. Holley, A. B. Collen, J. Shah, A. Lettieri, C. TI Gene Methylation In Bronchoalveolar Lavage Fluid From Patients With Cancer, Inflammatory Lung Disease, And Tobacco Exposure SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Greer, J.; Holley, A. B.; Collen, J.; Shah, A.; Lettieri, C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM aholley9@hotmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2010 VL 181 MA A2029 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V29TP UT WOS:000208771001236 ER PT J AU Kwon, H Morris, M AF Kwon, H. Morris, M. TI Spontaneous Pneumothorax In An Adult Male With A History Of Lobar Resection For Congenital Lobar Emphysema SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Kwon, H.; Morris, M.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM herb.kwon@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2010 VL 181 MA A1485 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V29TP UT WOS:000208771000485 ER PT J AU Mitchell, J Petteys, S Holley, AB Collen, J Shah, A AF Mitchell, J. Petteys, S. Holley, A. B. Collen, J. Shah, A. TI Venous Thromboembolism Prophylaxis Rates In Specific Patient Groups Using An Electonic Reminder Designed To Improve Compliance With ACCP Guidelines SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Mitchell, J.; Petteys, S.; Holley, A. B.; Collen, J.; Shah, A.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM aholley9@hotmail.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2010 VL 181 MA A1455 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V29TP UT WOS:000208771000456 ER PT J AU Peng, X Collins, JL Witriol, A Pierre, Z Bowens, C Rodriguez, A Olivera, D Sciuto, AM AF Peng, X. Collins, J. L. Witriol, A. Pierre, Z. Bowens, C. Rodriguez, A. Olivera, D. Sciuto, A. M. TI The Physiological And Biochemical Exposure-Response Effects To Inhaled Nerve Agents In Rats SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Meeting Abstract C1 [Peng, X.; Collins, J. L.; Witriol, A.; Pierre, Z.; Bowens, C.; Rodriguez, A.; Olivera, D.; Sciuto, A. M.] US Army, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER THORACIC SOC PI NEW YORK PA 61 BROADWAY, FL 4, NEW YORK, NY 10006 USA SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PY 2010 VL 181 MA A1755 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA V29TP UT WOS:000208771000755 ER PT J AU Forman, HP Crowe, JK Messinger, N Javitt, MC Larson, DB Norbash, A Kaye, A Thrall, JH Hricak, H Kazerooni, EA AF Forman, Howard P. Crowe, John K. Messinger, Neil Javitt, Marcia C. Larson, David B. Norbash, Alexander Kaye, Alan Thrall, James H. Hricak, Hedvig Kazerooni, Ella A. TI Masters of Radiology Panel Discussion: Responding to Health Care Reform and Other Market Pressures SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Editorial Material DE cost-efficiency; health care reform; hyperefficiency; productivity; reimbursement C1 [Forman, Howard P.] Yale Univ, MBA Program & MBA Execut, New Haven, CT 06520 USA. [Crowe, John K.] Scottsdale Med Imaging, Scottsdale, AZ USA. [Messinger, Neil] Baptist Hlth Syst, Dept Radiol, Miami, FL USA. [Javitt, Marcia C.] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. [Larson, David B.] Cincinnati Childrens Hosp, Med Ctr, Dept Radiol, Cincinnati, OH USA. [Norbash, Alexander] Boston Univ, Med Ctr, Dept Radiol, Boston, MA 02118 USA. [Kaye, Alan] Bridgeport Hosp, Dept Radiol, Westport, CT USA. [Thrall, James H.] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA. [Hricak, Hedvig] Mem Sloan Kettering Canc Ctr, Dept Radiol, Seattle, WA USA. [Kazerooni, Ella A.] Univ Michigan Hosp, Dept Radiol, Ann Arbor, MI 48109 USA. RP Forman, HP (reprint author), Yale Univ, MBA Program & MBA Execut, New Haven, CT 06520 USA. EM howard.forman@yale.edu OI Norbash, Alexander/0000-0003-2986-2563; Hricak, Hedvig/0000-0003-2240-9694 NR 1 TC 2 Z9 2 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JAN PY 2010 VL 194 IS 1 BP 173 EP 177 DI 10.2214/AJR.09.3715 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 535SH UT WOS:000272990500024 PM 20028920 ER PT J AU Todd, MS Lalliss, S Garcia, E DeBerardino, TM Cameron, KL AF Todd, Michael S. Lalliss, Steve Garcia, E'Stephan DeBerardino, Thomas M. Cameron, Kenneth L. TI The Relationship Between Posterior Tibial Slope and Anterior Cruciate Ligament Injuries SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE tibial slope; noncontact; ACL; risk factors ID INTERCONDYLAR NOTCH; RISK-FACTORS; VALGUS; WIDTH; SIZE; KNEE AB Background: Two previous studies have examined the association between an increased posterior tibial slope and anterior cruciate ligament (ACL) injuries as measured on plain radiographs. The study results were contradictory, with 1 reporting a statistical difference and the other showing no association. Purpose: To determine if there is a difference in posterior tibial slope angle between patients with a history of noncontact ACL injury and a control group with no history of ACL injury. A secondary objective was to examine differences in tibial slope angle between male and female subjects within each group. Study Design: Case-control study; Level of evidence, 3. Methods: We identified all noncontact ACL injuries that were treated operatively at the United States Military Academy, West Point, New York, from 2004 to 2007. We digitally measured the posterior tibial slope from plain film radiographs of 140 noncontact ACL injuries, stratified them by sex, and compared them with a control cohort of 179 patients and radiographs. Results: Subjects in the noncontact ACL group had significantly greater slope angles (9.39 degrees +/- 2.58 degrees) than did control subjects (8.50 degrees +/- 2.67 degrees) (P = .003). The trend toward greater tibial slope angles in the noncontact ACL group was also observed when each sex was examined independently; however, the difference was only statistically significant for the female subjects between the injury and control groups (9.8 degrees +/- 2.6 degrees vs 8.20 degrees +/- 2.4 degrees) (P = .002). Conclusion: Despite the identification of an increased posterior tibial slope as a possible risk factor for women, more research that combines the multifactorial nature of an ACL injury must be performed. C1 [Todd, Michael S.; Garcia, E'Stephan] William Beaumont Army Med Ctr, El Paso, TX 79912 USA. [Lalliss, Steve] Darnall Army Med Ctr, Ft Hood, TX USA. [DeBerardino, Thomas M.; Cameron, Kenneth L.] Keller Army Community Hosp, West Point, NY USA. RP Todd, MS (reprint author), William Beaumont Army Med Ctr, El Paso, TX 79912 USA. EM michael.todd@amedd.army.mil OI DeBerardino, Thomas/0000-0002-7110-8743; Cameron, Kenneth/0000-0002-6276-4482 NR 23 TC 63 Z9 69 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD JAN PY 2010 VL 38 IS 1 BP 63 EP 67 DI 10.1177/0363546509343198 PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 539XT UT WOS:000273293300007 PM 19737987 ER PT J AU Sueker, JJ Chretien, JP Gaydos, JC Russell, KL AF Sueker, J. Jeremy Chretien, Jean-Paul Gaydos, Joel C. Russell, Kevin L. TI Short Report: Global Infectious Disease Surveillance at DoD Overseas Laboratories, 1999-2007 SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID US MILITARY PERSONNEL; OPERATIONS IRAQI FREEDOM; PLASMODIUM-FALCIPARUM MALARIA; ENDURING FREEDOM; TRAVELERS DIARRHEA; BRIGHT STAR; NORTHERN EGYPT; UNITED-STATES; MIDDLE-EAST; EPIDEMIOLOGY AB The United States Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS) conducted a review in 2008 of projects funded by DoD-GEIS at five partner overseas laboratories from 1999 through 2007. During this period, the annual overseas programming budget grew from US$1.038 million to US$21. million. The review describes the distribution of project priorities and geographic locations over the years, the types of outcomes the projects generated, and the frequency with which they involved collaboration with other public health agencies and organizations, including CDC and WHO. Areas for further program strengthening are identified. C1 [Sueker, J. Jeremy; Gaydos, Joel C.; Russell, Kevin L.] Armed Forces Hlth Surveillance Ctr, Div GEIS Operat, Silver Spring, MD 20910 USA. [Chretien, Jean-Paul] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA. [Chretien, Jean-Paul] Johns Hopkins Univ, Sch Med, Div Hlth Sci Informat, Baltimore, MD 21205 USA. RP Sueker, JJ (reprint author), Armed Forces Hlth Surveillance Ctr, Div GEIS Operat, 2900 Linden Lane, Silver Spring, MD 20910 USA. EM Jsueker@alumni.tufts.edu NR 53 TC 2 Z9 3 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 2010 VL 82 IS 1 BP 23 EP 27 DI 10.4269/ajtmh.2010.09-0139 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 540VF UT WOS:000273367400006 PM 20064990 ER PT J AU Rice, RD Parker, DM Gallo, DM Arciero, CA AF Rice, Robert D. Parker, David M. Gallo, Dominic M. Arciero, Cletus A. TI Persistent Anterior Mediastinal Mass in a Patient with Graves' Disease SO AMERICAN SURGEON LA English DT Letter ID THYMIC HYPERPLASIA C1 [Rice, Robert D.] Dwitht David Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Rice, RD (reprint author), Dwitht David Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. EM Robert.D.Rice@amedd.army.mil NR 6 TC 2 Z9 2 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD JAN PY 2010 VL 76 IS 1 BP 113 EP 115 PG 3 WC Surgery SC Surgery GA 546TG UT WOS:000273834200025 PM 20135954 ER PT J AU Brockmeyer, JR Rice, RD Seery, JM Ziemba, MG AF Brockmeyer, Joel R. Rice, Robert D. Seery, Jason M. Ziemba, Mark G. TI Sclerosing Sweat Duct Carcinoma in the Left Axilla Presenting as Metastatic Breast Cancer SO AMERICAN SURGEON LA English DT Letter ID MICROCYSTIC ADNEXAL CARCINOMA C1 [Brockmeyer, Joel R.; Rice, Robert D.; Seery, Jason M.; Ziemba, Mark G.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Brockmeyer, JR (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. EM Joel.R.Brockmeyer@amedd.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD JAN PY 2010 VL 76 IS 1 BP 119 EP 120 PG 2 WC Surgery SC Surgery GA 546TG UT WOS:000273834200028 PM 20135957 ER PT J AU Brockmeyer, JR Rice, RD Seery, JM Arciero, CA Sterenchock, TD AF Brockmeyer, Joel R. Rice, Robert D. Seery, Jason M. Arciero, Cletus A. Sterenchock, Trent D. TI Primary Embryonal Rhabdomyosarcoma of the Prostate in an Adult SO AMERICAN SURGEON LA English DT Letter C1 [Brockmeyer, Joel R.; Rice, Robert D.; Seery, Jason M.; Arciero, Cletus A.; Sterenchock, Trent D.] Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. RP Brockmeyer, JR (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Gen Surg, Ft Gordon, GA 30905 USA. EM Joel.R.Brockmeyer@amedd.army.mil NR 4 TC 2 Z9 2 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD JAN PY 2010 VL 76 IS 1 BP 122 EP 123 PG 2 WC Surgery SC Surgery GA 546TG UT WOS:000273834200030 PM 20135959 ER PT J AU Qashu, F Figueiredo, TH Aroniadou-Anderjaska, V Apland, JP Braga, MFM AF Qashu, Felicia Figueiredo, Taiza H. Aroniadou-Anderjaska, Vassiliki Apland, James P. Braga, Maria F. M. TI Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis SO AMINO ACIDS LA English DT Article DE Amygdala; Hippocampus; Benzodiazepines; Status epilepticus; Neurodegeneration; Epileptogenesis ID TEMPORAL-LOBE EPILEPSY; LIMBIC STATUS EPILEPTICUS; CONVULSIVE STATUS EPILEPTICUS; KAINIC ACID; ELECTRICAL-STIMULATION; FUNCTIONAL-ANATOMY; PILOCARPINE MODEL; GABA(A) RECEPTORS; NEURONAL DAMAGE; CELL-DEATH AB An episode of status epilepticus (SE), if left untreated, can lead to death, or brain damage with long-term neurological consequences, including the development of epilepsy. The most common first-line treatment of SE is administration of benzodiazepines (BZs). However, the efficacy of BZs in terminating seizures is reduced with time after the onset of SE; this is accompanied by a reduced efficacy in protecting the hippocampus against neuronal damage, and is associated with impaired function and internalization of hippocampal GABA(A) receptors. In the present study, using Fluoro-Jade C staining, we found that administration of diazepam to rats at 3 h after the onset of kainic acid-induced SE, at a dose sufficient to terminate SE, had no protective effect on the hippocampus, but produced a significant reduction in neuronal degeneration in the amygdala, piriform cortex, and endopiriform nucleus, examined on days 7-9 after SE. Thus, in contrast to the hippocampus, the amygdala and other limbic structures are responsive to neuroprotection by BZs after prolonged SE, suggesting that GABA(A) receptors are not significantly altered in these structures during SE. C1 [Figueiredo, Taiza H.; Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. [Qashu, Felicia; Aroniadou-Anderjaska, Vassiliki; Braga, Maria F. M.] Uniformed Serv Univ Hlth Sci, Neurosci Program, Bethesda, MD 20814 USA. [Apland, James P.] USA, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen Proving Ground, MD 21010 USA. RP Braga, MFM (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Anat Physiol & Genet, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM mbraga@usuhs.mil FU National Institute of Neurological Disorders and Stroke [U01 NS058162-01]; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division [1.E0021_07_US_C] FX This work was funded by the National Institutes of Health CounterACT Program through the National Institute of Neurological Disorders and Stroke (award # U01 NS058162-01). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the federal government. This work was also supported by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (grant 1.E0021_07_US_C). NR 59 TC 18 Z9 20 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0939-4451 J9 AMINO ACIDS JI Amino Acids PD JAN PY 2010 VL 38 IS 1 BP 189 EP 197 DI 10.1007/s00726-008-0227-2 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 553RH UT WOS:000274384000020 PM 19127342 ER PT J AU Fernandez-Maestre, R Harden, CS Ewing, RG Crawford, CL Hill, HH AF Fernandez-Maestre, Roberto Harden, Charles Steve Ewing, Robert Gordon Crawford, Christina Lynn Hill, Herbert Henderson, Jr. TI Chemical standards in ion mobility spectrometry SO ANALYST LA English DT Article ID FLIGHT MASS-SPECTROMETRY; ELECTROSPRAY-IONIZATION; AMBIENT-PRESSURE; PLASMA CHROMATOGRAPHY; DEGRADATION-PRODUCTS; RESOLUTION; GAS; TIME; AIR; SEPARATION AB In ion mobility spectrometry (IMS), reduced mobility values (K(0)) are used as a qualitative measure of gas phase ions, and are reported in the literature as absolute values. Unfortunately, these values do not always match with those collected in the field. One reason for this discrepancy is that the buffer gas may be contaminated with moisture or other volatile compounds. In this study, the effect of moisture and organic contaminants in the buffer gas on the mobility of IMS standards and analytes was investigated for the first time using IMS directly coupled to mass spectrometry. 2,4-Dimethylpyridine, 2,6-di-tertbutylpyridine (DTBP), and tetrabutylammonium, tetrapropylammonium, tetraethylammonium, and tetramethylammonium chlorides were used as chemical standards. In general, the mobility of IMS standard product ions was not affected by small amounts of contamination while the mobilities of many analytes were affected. In the presence of contaminants in the buffer gas, the mobility of analyte ions is often decreased by forming ion-molecule clusters with the contaminant. To ensure the measurement of accurate reduced mobility values, two IMS standards are required: an instrument and a mobility standard. An instrument standard is not affected by contaminants in the buffer gas, and provides an accurate measurement of the instrumental parameters, such as voltage, drift length, pressure, and temperature. The mobility standard behaves like an analyte ion in that the compound's mobility is affected by low levels of contamination in the buffer gas. Prudent use of both of these standards can lead to improved measurement of accurate reduced mobility values. C1 [Fernandez-Maestre, Roberto; Crawford, Christina Lynn; Hill, Herbert Henderson, Jr.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA. [Harden, Charles Steve] USA, SAIC, Edgewood Chem Biol Ctr Operat, Gunpowder, MD 21010 USA. [Ewing, Robert Gordon] Pacific NW Natl Lab, Richland, WA 99354 USA. [Fernandez-Maestre, Roberto] Univ Cartagena, Grp Quim Aplicada, Programa Quim, Cartagena, Colombia. RP Hill, HH (reprint author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA. EM hhhill@wsu.edu OI Fernandez-Maestre, Roberto/0000-0001-6791-5318 FU Science Applications Intl.; SAIC/US Army, Edgewood Chemical Biological Center Operations FX This work was supported by a grant from Science Applications Intl. and in part by a grant from SAIC/US Army, Edgewood Chemical Biological Center Operations P.O. Box 68 Gunpowder, MD 21010-0068, USA. NR 53 TC 37 Z9 38 U1 2 U2 37 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 0003-2654 J9 ANALYST JI Analyst PY 2010 VL 135 IS 6 BP 1433 EP 1442 DI 10.1039/b915202d PG 10 WC Chemistry, Analytical SC Chemistry GA 600TM UT WOS:000278011800039 PM 20369157 ER PT J AU Dworzanski, JP Dickinson, DN Deshpande, SV Snyder, AP Eckenrode, BA AF Dworzanski, Jacek P. Dickinson, Danielle N. Deshpande, Samir V. Snyder, A. Peter Eckenrode, Brian A. TI Discrimination and Phylogenomic Classification of Bacillus anthracis-cereus-thuringiensis Strains Based on LC-MS/MS Analysis of Whole Cell Protein Digests SO ANALYTICAL CHEMISTRY LA English DT Article ID DNA-DNA HYBRIDIZATION; SPECTROMETRY-BASED PROTEOMICS; ACID-SOLUBLE PROTEINS; 16S RIBOSOMAL-RNA; AD-HOC-COMMITTEE; MASS-SPECTROMETRY; MICROORGANISM IDENTIFICATION; SPECIES DEFINITION; DATABASE SEARCH; SEQUENCE AB Modem taxonomy, diagnostics, and forensics of bacteria benefit from technologies that provide data for genome-based classification and identification of strains; however, full genome sequencing is still costly, lengthy, and labor intensive. Therefore, other methods are needed to estimate genomic relatedness among strains in an economical and timely manner. Although DNA-DNA hybridization and techniques based on genome fingerprinting or sequencing selected genes like 16S rDNA, gyrB, or rpoB are frequently used as phylogenetic markers, analyses of complete genome sequences showed that global measures of genome relatedness, such as the average genome conservation of shared genes, can provide better strain resolution and give phylogenies congruent with relatedness revealed by traditional phylogenetic markers. Bacterial genomes are characterized by a high gene density; therefore, we investigated the integration of mass spectrometry-based proteomic techniques with statistical methods for phylogenomic classification of bacterial strains. For this purpose, we used a set of well characterized Bacillus cereus group strains isolated from poisoned food to describe a method that relies on liquid chromatography-electrospray ionization-tandem mass spectrometry of tryptic peptides derived from whole cell digests. Peptides were identified and matched to a prototype database (DB) of reference bacteria with fully sequenced genomes to obtain their phylogenetic profiles. These profiles were processed for predicting genomic similarities with DB bacteria estimated by fractions of shared peptides (FSPs). FSPs served as descriptors for each food isolate and were jointly analyzed using hierarchical cluster analysis methods for revealing relatedness among investigated strains. The results showed that phylogenomic classification of tested food isolates was in consonance with results from established genomic methods, thus validating our findings. In conclusion, the proposed approach could be used as an alternative method for predicting relatedness among microbial genomes of B. cereus group members and potentially may circumvent the need for whole genome sequencing for phylogenomic typing of strains. C1 [Dworzanski, Jacek P.] Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. [Dickinson, Danielle N.] Northrop Grumman Elect Syst, Baltimore, MD 21203 USA. [Deshpande, Samir V.] Sci & Technol Corp, Edgewood, MD 21040 USA. [Snyder, A. Peter] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Eckenrode, Brian A.] FBI Counterterrorism & Forens Sci Res Unit, Quantico, VA 22135 USA. RP Dworzanski, JP (reprint author), Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. EM jacek.p.dwortzanski@gmail.com FU U.S. Department of Energy; FBI-CTFSRU FX This research was supported in part by an appointment to the Research Participation Program at the Federal Bureau of Investigation, Counterterrorism and Forensic Science Research Unit (FBI-CTFSRU), administered by the Oak Ridge Institute of Science and Education through an interagency agreement between the U.S. Department of Energy and FBI-CTFSRU. The authors would also like to thank M. Satomi and K. Venkateswaran for providing the bacterial strains used in this study. NR 55 TC 10 Z9 12 U1 2 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0003-2700 EI 1520-6882 J9 ANAL CHEM JI Anal. Chem. PD JAN 1 PY 2010 VL 82 IS 1 BP 145 EP 155 DI 10.1021/ac9015648 PG 11 WC Chemistry, Analytical SC Chemistry GA 539OT UT WOS:000273265700029 PM 19938824 ER PT J AU Cohen, SP Strassels, SA Kurihara, C Forsythe, A Buckenmaier, CC McLean, B Riedy, G Seltzer, S AF Cohen, Steven P. Strassels, Scott A. Kurihara, Connie Forsythe, Akara Buckenmaier, Chester C., III McLean, Brian Riedy, Gerard Seltzer, Sharon TI Randomized Study Assessing the Accuracy of Cervical Facet Joint Nerve (Medial Branch) Blocks Using Different Injectate Volumes SO ANESTHESIOLOGY LA English DT Article ID LOW-BACK-PAIN; RADIOFREQUENCY DENERVATION; ASYMPTOMATIC SUBJECTS; MULTICENTER ANALYSIS; COMPUTED-TOMOGRAPHY; COST-EFFECTIVENESS; SPINAL PAIN; DORSAL RAMI; LUMBAR; PREVALENCE AB Background: Neck pain is a frequent cause of disability, with facet joint arthropathy accounting for a large percentage of cases, The diagnosis of cervical facet joint pain is usually made with diagnostic blocks of the nerves that innervate them. Yet, medial branch blocks are associated with a high false-positive rate. One hypothesized cause of inaccurate diagnostic blocks is inadvertent extravasation of injectate into adjacent pain-generating structures. The objective of this study was to evaluate the accuracy of medial branch blocks by using different injectate volumes. Methods: Twenty-four patients received cervical medial branch blocks, using either 0.5 or 0.25 ml of buipivacaine mixed with contrast. One half of the patients in each group were suballocated to receive the blocks in the prone position and the other half through a lateral approach. Participants then underwent computed tomography of the cervical spine to evaluate accuracy and patterns of aberrant contrast spread. Results: Sixteen instances of aberrant spread were observed in nine patients receiving blocks using 0.5 ml versus seven occurrences in six patients in the 0.25 ml group (P = 0.07). Aberrant spread was most commonly observed (57%) when an injection at C3 engulfed the third occipital nerve. Among the 86 nerve blocks, foraminal spread occurred in five instances using 0.5 ml and in two cases with 0.25 ml. The six "missed" nerves were equally divided between treatment groups. No significant difference in any outcome measure was observed between the prone and lateral positions. Conclusions: Reducing the volume during cervical medial branch blocks may improve precision and accuracy. C1 Johns Hopkins Sch Med, Dept Anesthesiol, Baltimore, MD USA. [Kurihara, Connie] Walter Reed Army Med Ctr, Pain Management Ctr, Washington, DC 20307 USA. [Buckenmaier, Chester C., III] Walter Reed Army Med Ctr, Dept Anesthesiol, Washington, DC 20307 USA. [Riedy, Gerard; Seltzer, Sharon] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Cohen, SP (reprint author), 550 North Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu FU John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania; U.S. Army, and the Army Regional Anesthesia and Pain Medicine Initiative, Washington, D.C; NIH [NCT006133410] FX Received front the Departments of Anesthesiology, Johns Hopkins School of Medicine, Baltimore, Maryland, and Walter Reed Army Medical Center, Washington, D.C. Submitted for publication May 4 2009. Accepted for publication September 16, 2009. Supported in part by a Congressional Grant from the John P. Murtha Neuroscience and Pain Institute, Johnstown, Pennsylvania, the U.S. Army, and the Army Regional Anesthesia and Pain Medicine Initiative, Washington, D.C. NIH clinical trials identifier: NCT006133410. The opinions or assertions contained herein are the private views of the authors and are riot to he construed as official or as reflecting the views of the Dei of the Army, or the Department of Defense. NR 41 TC 27 Z9 27 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD JAN PY 2010 VL 112 IS 1 BP 144 EP 152 PG 9 WC Anesthesiology SC Anesthesiology GA 540EP UT WOS:000273314200022 PM 19996954 ER PT J AU Andrews, RS Becker, JJ Gagne, MR AF Andrews, R. Stephen Becker, Jennifer J. Gagne, Michel R. TI Intermolecular Addition of Glycosyl Halides to Alkenes Mediated by Visible Light SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION LA English DT Article DE alkenes; C-glycosides; homogeneous catalysis; photooxidation; ruthenium ID BOND-DISSOCIATION ENERGIES; CROSS-COUPLING APPROACH; C-GLYCOSIDES; PHOTOREDOX CATALYSIS; ELECTRON-TRANSFER; GLYCOSYLTRANSFERASE INHIBITORS; SYNTHETIC APPLICATIONS; RADICALS; PHOTOCATALYSIS; ORGANOCATALYSIS C1 [Andrews, R. Stephen; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Becker, Jennifer J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM mgagne@email.unc.edu FU Army Research Office; Department of Energy [DE-FG02-05ER15630] FX We thank Aaron J. Francis for his contribution to optimization and Prof. Malcolm Forbes for his help with EPR experiments. The Army Research Office Staff Research Funding and Department of Energy (DE-FG02-05ER15630) are gratefully acknowledged for their support. NR 50 TC 137 Z9 137 U1 5 U2 48 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1433-7851 J9 ANGEW CHEM INT EDIT JI Angew. Chem.-Int. Edit. PY 2010 VL 49 IS 40 BP 7274 EP 7276 DI 10.1002/anie.201004311 PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 663UX UT WOS:000282916800021 PM 20740519 ER PT S AU Dalton, K Hall, JB AF Dalton, Ken Hall, J. Brian GP IEEE TI Implementing New RAM Initiatives In Army Test And Evaluation SO ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM, 2010 PROCEEDINGS SE Reliability and Maintainability Symposium LA English DT Proceedings Paper CT Annual Reliability and Maintainability Symposium/International Symposium on Product Quality and Integrity CY JAN 25-28, 2010 CL San Jose, CA SP AIAA, IEEE, ASQ, IEST, IIE, SAE, SOLE, SRE, SSS DE design for reliability; reliability growth; reliability program scorecard; contract language AB This paper describes the processes for implementing new Department of the Army (DA) reliability policy directives [1] issued by the Assistant Secretary of the Army for Acquisition, Logistics, and Technology, or ASA(ALT). It highlights key points of the implementation guide [2] prepared by the U. S. Army Evaluation Center (AEC) and the U. S. Army Test and Evaluation Command (ATEC). The implementation plan herein utilizes GEIA-STD-0009 [3] for developing contract language promoting reliability best practices. The Army Materiel Systems Analysis Activity's (AMSAA's) new Reliability Program Scorecard [4] is used for performing early-on engineering evaluations of contractor reliability engineering activities. Note that both of these tools are outcomes of the Department of Defense (DoD) Reliability Improvement Working Group (RIWG) [5]. The implementation plan also addresses the Defense Science Board (DSB) recommendation [6] and the new DoD acquisition regulations [7] to establish Reliability Growth (RG) programs for developmental systems. Growth programs and associated planning curves are constructed via AMSAA's Planning Model based on Projection Methodology, hereafter referred to as PM2 [8, 9]. Finally, AMSAA's COnsumption, HOlding, Repair and Transportation (COHORT) cost model [10, 11] is utilized to identify life cycle cost impacts for systems that breach their established reliability thresholds. C1 [Dalton, Ken] USA, Evaluat Ctr AEC, TEAE REG, 4120 Susquehanna Ave, Aberdeen Proving Ground, MD 21005 USA. [Hall, J. Brian] USA, Evaluat Ctr, TEAE REG, Aberdeen Proving Ground, MD 21005 USA. RP Dalton, K (reprint author), USA, Evaluat Ctr AEC, TEAE REG, 4120 Susquehanna Ave, Aberdeen Proving Ground, MD 21005 USA. EM ken.dalton@us.army.mil; brian.hall@us.army.mil NR 16 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 0149-144X BN 978-1-4244-5103-6 J9 P REL MAINT S PY 2010 PG 6 WC Engineering, Multidisciplinary; Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA BTL33 UT WOS:000287207000020 ER PT S AU Miyahira, SD Folen, RA Stetz, M Rizzo, A Kawasaki, MM AF Miyahira, Sarah D. Folen, Raymond A. Stetz, Melba Rizzo, Albert Kawasaki, Michelle M. BE Wiederhold, BK Riva, G Kim, SI TI Use of Immersive Virtual Reality for Treating Anger SO ANNUAL REVIEW OF CYBERTHERAPY AND TELEMEDICINE 2010: ADVANCED TECHNOLOGIES IN BEHAVIORAL, SOCIAL AND NEUROSCIENCES SE Studies in Health Technology and Informatics LA English DT Article; Book Chapter DE Virtual reality; anger treatment; cue arousal; presence ID HOSTILITY; THERAPY; MEN AB Poorly managed anger responses can be detrimental to one's physical and psychosocial well-being. Cognitive behavior therapies (CBT) have been found to be effective in treating anger disorders. A key component of CBT treatment is exposure to the anger arousing stimuli. Virtual reality (VR) environments can elicit potent reactions and may facilitate the treatment of anger. An anger VR environment with six video vignettes was developed by this study to examine the anger arousal potential of VR. Outcome measures included assessment of emotional reactivity, state anger, and presence. The results showed that significant anger arousal occurred during exposure to the VR environment, and arousal was greater when viewed in an immersive HMD than a non-immersive flat screen. In addition, presence was found to moderate the effects of VR. Low presence resulted in low reactivity regardless of the display modality. C1 [Miyahira, Sarah D.] VA Pacific Isl Hlth Care Syst, Honolulu, HI 96819 USA. [Folen, Raymond A.; Stetz, Melba] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Rizzo, Albert] Univ So Calif, Los Angeles, CA USA. [Kawasaki, Michelle M.] Univ Hawaii, Honolulu, HI 96822 USA. RP Miyahira, SD (reprint author), VA Pacific Isl Hlth Care Syst, 459 Patterson Rd, Honolulu, HI 96819 USA. EM sarah.miyahira@va.gov NR 8 TC 5 Z9 5 U1 0 U2 1 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0926-9630 BN 978-1-60750-561-7 J9 STUD HEALTH TECHNOL PY 2010 VL 154 BP 82 EP 86 DI 10.3233/978-1-60750-561-7-82 PG 5 WC Computer Science, Interdisciplinary Applications; Health Care Sciences & Services SC Computer Science; Health Care Sciences & Services GA BJP47 UT WOS:000329497000017 PM 20543275 ER PT S AU Miyahira, SD Folen, RA Hoffman, HG Garcia-Palacios, A Schaper, KM AF Miyahira, Sarah D. Folen, Raymond A. Hoffman, Hunter G. Garcia-Palacios, Azucena Schaper, Kim M. BE Wiederhold, BK Riva, G Kim, SI TI Effectiveness of Brief VR Treatment for PTSD in War-Fighters: A Case Study SO ANNUAL REVIEW OF CYBERTHERAPY AND TELEMEDICINE 2010: ADVANCED TECHNOLOGIES IN BEHAVIORAL, SOCIAL AND NEUROSCIENCES SE Studies in Health Technology and Informatics LA English DT Article; Book Chapter DE Virtual reality; PTSD; exposure therapy; combat ID POSTTRAUMATIC-STRESS-DISORDER; REALITY EXPOSURE THERAPY; INVENTORY AB War-fighters exposed to combat are at high risk for developing posttraumatic stress disorder (PTSD), a complex and challenging condition to treat. Cognitive behavioral therapies (CBT) have been empirically validated as effective treatments for PTSD resulting from sexual assault, vehicular accidents, and disasters. Exposure, imaginal or in vivo, to the traumatic event is a central component of successful CBT treatment. Early studies indicate that CBT with brief virtual reality exposure (VRE) is beneficial in treating PTSD. The case study examined the effectiveness of brief VRE in treating combat-related PTSD. C1 [Miyahira, Sarah D.] VA Pacific Isl Hlth Care Syst, Honolulu, HI 96819 USA. [Folen, Raymond A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Hoffman, Hunter G.] Univ Washington, Seattle, WA 98195 USA. [Garcia-Palacios, Azucena] Univ Jaume 1, Castellon de La Plana, Spain. [Schaper, Kim M.] Univ Hawaii Manoa, Honolulu, HI 96822 USA. RP Miyahira, SD (reprint author), VA Pacific Isl Hlth Care Syst, 459 Patterson Rd, Honolulu, HI 96819 USA. EM sarah.miyahira@va.gov OI Garcia-Palacios, Azucena/0000-0001-9250-8714 NR 17 TC 1 Z9 1 U1 2 U2 12 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 0926-9630 BN 978-1-60750-561-7 J9 STUD HEALTH TECHNOL PY 2010 VL 154 BP 214 EP 219 DI 10.3233/978-1-60750-561-7-214 PG 6 WC Computer Science, Interdisciplinary Applications; Health Care Sciences & Services SC Computer Science; Health Care Sciences & Services GA BJP47 UT WOS:000329497000042 PM 20543300 ER PT S AU Galyov, EE Brett, PJ DeShazer, D AF Galyov, Edouard E. Brett, Paul J. DeShazer, David BE Gottesman, S Harwood, CS TI Molecular Insights into Burkholderia pseudomallei and Burkholderia mallei Pathogenesis SO ANNUAL REVIEW OF MICROBIOLOGY, VOL 64, 2010 SE Annual Review of Microbiology LA English DT Review; Book Chapter DE melioidosis; glanders; bacterial pathogen; intracellular; virulence ID III SECRETION SYSTEM; ACTIN-BASED MOTILITY; QUORUM-SENSING SYSTEM; ANTIGENIC POLYSACCHARIDE MOIETY; RAW-264.7 MURINE MACROPHAGES; SIGNATURE-TAGGED MUTAGENESIS; MAJOR VIRULENCE DETERMINANT; SELECT-AGENT-COMPLIANT; VI-SECRETION; CAPSULAR POLYSACCHARIDE AB Burkholderia pseudomallei and Burkholderia mallet are closely related gram-negative bacteria that can cause serious diseases in humans and animals This review summarizes the current and rapidly expanding knowledge on the specific virulence factors employed by these pathogens and their roles in the pathogenesis of melioidosis and glanders In particular, the contributions of recently identified virulence factors are described in the context of the intracellular lifestyle of these pathogens Throughout this review, unique and shared virulence features of B pseudomallei and B mallei are discussed C1 [Galyov, Edouard E.] Univ Leicester, Dept Infect Immun & Inflammat MSB, Leicester LF1 9HN, Leics, England. [Brett, Paul J.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA. [DeShazer, David] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Galyov, EE (reprint author), Univ Leicester, Dept Infect Immun & Inflammat MSB, Leicester LF1 9HN, Leics, England. FU Wellcome Trust NR 130 TC 119 Z9 125 U1 9 U2 55 PU ANNUAL REVIEWS PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA SN 0066-4227 BN 978-0-8243-1164-3 J9 ANNU REV MICROBIOL JI Annu. Rev. Microbiol. PY 2010 VL 64 BP 495 EP 517 DI 10.1146/annurev.micro.112408.134030 PG 23 WC Microbiology SC Microbiology GA BSA47 UT WOS:000284030600026 PM 20528691 ER PT S AU Ho, SA Hung, N AF Ho, Sean Hung Nguyen BE Tescher, AG TI Computational Architecture for Image Processing on a Small Unmanned Ground Vehicle SO APPLICATIONS OF DIGITAL IMAGE PROCESSING XXXIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Applications of Digital Image Processing XXXIII CY AUG 02-04, 2010 CL San Diego, CA SP SPIE DE computational architecture; image processing; surveillance AB Man-portable Unmanned Ground Vehicles (UGVs) have been fielded on the battlefield with limited computing power. This limitation constrains their use primarily to teleoperation control mode for clearing areas and bomb defusing. In order to extend their capability to include the reconnaissance and surveillance missions of dismounted soldiers, a separate processing payload is desired. This paper presents a processing architecture and the design details on the payload module that enables the PackBot to perform sophisticated, real-time image processing algorithms using data collected from its onboard imaging sensors including LADAR, IMU, visible, IR, stereo, and the Ladybug spherical cameras. The entire payload is constructed from currently available Commercial off-the-shelf (COTS) components including an Intel multi-core CPU and a Nvidia GPU. The result of this work enables a small UGV to perform computationally expensive image processing tasks that once were only feasible on a large workstation. C1 [Ho, Sean; Hung Nguyen] USA, Res Lab, Adelphi, MD 20783 USA. RP Ho, SA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 25 TC 0 Z9 0 U1 1 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8294-5 J9 PROC SPIE PY 2010 VL 7798 AR 77980D DI 10.1117/12.863554 PG 10 WC Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Computer Science; Engineering; Optics; Imaging Science & Photographic Technology GA BTQ34 UT WOS:000287763500008 ER PT S AU Sahin, CS Gundry, S Urrea, E Uyar, MU Conner, M Bertoli, G Pizzo, C AF Sahin, Cem Safak Gundry, Stephen Urrea, Elkin Uyar, M. Uemit Conner, Michael Bertoli, Giorgio Pizzo, Christian BE DiChio, C Brabazon, A DiCaro, GA Ebner, M Farooq, M Fink, A Grahl, J Greenfield, G Machado, P ONeill, M Tarantino, E Urquhart, N TI Markov Chain Models for Genetic Algorithm Based Topology Control in MANETs SO APPLICATIONS OF EVOLUTIONARY COMPUTATION, PT II, PROCEEDINGS SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT Evo Applications 2010 Conference CY APR 07-09, 2010 CL Istanbul, TURKEY SP Istanbul Tech Univ, Microsoft Turkey, Sci & Technol Res Council Turkey, Edinburgh Napier Univ, Ctr Emergent Comp DE Bio-inspired Algorithms; Genetic Algorithms; MANET; Markov Chains AB We analyze the convergence properties of our force based genetic algorithm(FGA) as a decentralized topology control mechanism distributed among software agents. PGA guides autonomous mobile agents over an unknown geographical area to obtain a uniform node distribution. The stochastic behavior of PGA makes it difficult to analyze the effects of various MANET characteristics over its convergence rate. We present ergodic homogeneous Markov chains to analyze the convergence of our PGA with respect to changing communication range of mobile nodes. Simulation experiments indicate that the increased communication range for the mobile nodes does not result in a faster convergence. C1 [Sahin, Cem Safak; Gundry, Stephen; Urrea, Elkin; Uyar, M. Uemit; Conner, Michael] CUNY City Coll, New York, NY 10031 USA. [Sahin, Cem Safak; Gundry, Stephen; Urrea, Elkin; Uyar, M. Uemit; Conner, Michael] CUNY, Grad Ctr, New York, NY 10031 USA. [Bertoli, Giorgio; Pizzo, Christian] US Army, Commun Elect RD&E Ctr, Fort Monmouth, NJ USA. RP Sahin, CS (reprint author), CUNY City Coll, New York, NY 10031 USA. EM csahin@gc.cuny.edu; sgundry00@ccny.cuny.edu; eurrea@gc.cuny.edu; uyar@ccny.cuny.edu; conner@ccny.cuny.edu; Giorgio.Bertoli@us.army.mil; Christian.Pizzo@us.army.mil FU u.s. Army Communications-Electronics rde Center; National Science Foundation [ecs-0421159, cns-0619577] FX This work has been supported by u.s. Army Communications-Electronics rd&e Center. The contents of this document represent the views of the authors and are not necessarily the official views of, or are endorsed by, the u.s. Government, Department of Defense, Department of the Army, or the u.s. Army Communications-Electronics rd&e Center. This work has been supported by the National Science Foundation grants ecs-0421159 and cns-0619577. NR 18 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-12241-5 J9 LECT NOTES COMPUT SC PY 2010 VL 6025 BP 41 EP + PG 3 WC Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA BPZ01 UT WOS:000280403600005 ER PT J AU Swenson, GW White, MJ Oelze, ML AF Swenson, George W., Jr. White, Michael J. Oelze, Michael L. TI Low-frequency sound wave parameter measurement in gravels SO APPLIED ACOUSTICS LA English DT Article DE Attenuation; Phase velocity; Wavelength; Porous media; Granular media; Impedance tube; Gravel ID GROUND SURFACES; FLOW RESISTIVITY; IMPEDANCE; PROPAGATION; SOILS; ATTENUATION; SPEED; RANGE AB Experiments were performed to measure the various sound-wave propagation parameters of two kinds of gravel, a crushed limestone and a stream-formed "pea gravel", at frequencies between 25 and 200 Hz. The apparatus was a very large standing-wave tube with an array of microphones along its entire length. Measurements were made with the tube in the vertical position, filled to various depths, with a pressure-doubling barrier at the bottom. Values were determined for wavelength and attenuation in the gravel and for input impedance at the boundary between gravel and air. The basic analysis method was to fit the parameters of a presumed Green's function representing the standing wave in the tube to the measured sound pressure amplitudes measured by the microphones. This worked well for some frequencies and some depths of gravel. In other cases, various modifications of the method gave more consistent results. For crushed limestone, the estimates of phase velocity and attenuation increased monotonically with frequency, ranging between 150 and 250 m/s and 0.1 and 0.8 Np/m, respectively. For pea gravel, the estimates increased monotonically with frequency, with values between 160 and 205 m/s and 0.4 and 1.1 Np/m, respectively. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Swenson, George W., Jr.; Oelze, Michael L.] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. [White, Michael J.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Swenson, GW (reprint author), Univ Illinois, Dept Elect & Comp Engn, 1308 W Main St, Urbana, IL 61801 USA. EM gswenson@illinois.edu RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 FU University of Illinois at Urbana-Champaign [W9132T-06-2-0002]; US Army Construction Engineering Research Laboratory (CERL) [W9132T-06-2-0002] FX This work was conducted under Agreement No. W9132T-06-2-0002, Upper Mississippi Valley Cooperative Ecosystems Studies Unit., between the University of Illinois at Urbana-Champaign and the US Army Construction Engineering Research Laboratory (CERL). The experiments are conducted on the premises of and with the facilities of CERL. The authors acknowledge the contributions of former Graduate Research Assistants Timothy Onder, Ryan Lee, Timothy Eggerding and Todd Borrowman, and of CERL employees Dr. Larry Pater, Niels Svendsen, Dr. Michelle Swearingen, Jeffery Mifflin, Robert Klein and Bruce MacAllister. Thanks are given to two anonymous reviewers whose questions prompted significant revision of the manuscript. NR 22 TC 3 Z9 3 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0003-682X J9 APPL ACOUST JI Appl. Acoust. PD JAN PY 2010 VL 71 IS 1 BP 45 EP 51 DI 10.1016/j.apacoust.2009.07.003 PG 7 WC Acoustics SC Acoustics GA 504UG UT WOS:000270642600006 ER PT J AU Zaghloul, AI Weiss, SJ Coburn, WK AF Zaghloul, Amir I. Weiss, Steven J. Coburn, W. Keefe TI Antenna Developments for Military Applications SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article; Proceedings Paper CT 25th International Review of Progress in Applied Computational Electromagnetics CY MAR 08-12, 2009 CL Monterey, CA DE Antenna Modeling; Army; Military; In-Situ AB A review of current, past and projected activities in antenna development indicates a broad spectrum of requirements, and subsequently a variety of innovations to meet these requirements for military radar and communications systems. Designing the antennas in the operating environment, known as in-situ design, is an important factor in guaranteeing the successful operation of the antenna in the field. This paper presents the basic blocks in antenna development, followed by examples of some antennas developed at the Army Research Laboratory for military systems and applications. These include Rotman lenses as beam formers for electronically scanning arrays; phased arrays using MEMS phase shifters at 30 GHz; a 76-GHz narrow beam, low-sidelobe antenna for collision avoidance radar; and other specialized antennas. Of special interest is an effort on developing and using metamaterials in antenna designs, where practical realizations of such materials have the potential of improving the performance and reducing the size of antennas. C1 [Zaghloul, Amir I.; Weiss, Steven J.; Coburn, W. Keefe] USA, Res Lab, Adelphi, MD 20783 USA. [Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Dept Elect & Comp Engn, Blacksburg, VA 22043 USA. RP Zaghloul, AI (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM amir.zaghloul@us.army.mil; steven.weiss@us.army.mil; william.coburn@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 2 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD JAN PY 2010 VL 25 IS 1 SI SI BP 41 EP 53 PG 13 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 589PN UT WOS:000277164600005 ER PT J AU Coburn, W AF Coburn, William TI A Numerical Study of Coaxial Helical Antennas SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article; Proceedings Paper CT 25th International Review of Progress in Applied Computational Electromagnetics CY MAR 08-12, 2009 CL Monterey, CA DE Helical antenna; circular polarization; dual-band; fiberglass; Method of Moments; FEKO AB A FEKO model was constructed to investigate two helical antennas integrated coaxially on a shaped ground plane. One antenna was designed to have a reasonable gain and axial ratio (AR) from 0.5-0.9 GHz and the other from 1.0-1.6 GHz. In principle, the antennas could be connected in parallel to provide a near 50 Omega input impedance and act as a wideband antenna. However, this connection is problematic and can make fabrication more complex while changing the input impedance in unpredictable ways. An alternative is to use a microstrip impedance transformer to provide a 50 Omega input to each antenna. Then a broadband splitter can be used for a single feed wideband antenna. Otherwise, these two ports with switched input allow dual-band operation. The FEKO model is described and simulation results are presented for both cases. These results encourage further virtual prototyping and prototype fabrication for model validation. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Coburn, W (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM wcoburn@arl.army.mil NR 5 TC 0 Z9 0 U1 0 U2 2 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD JAN PY 2010 VL 25 IS 1 SI SI BP 61 EP 68 PG 8 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 589PN UT WOS:000277164600007 ER PT J AU Shubitidze, F Fernandez, JP Shamatava, I Pasion, LR Barrowes, BE O'Neill, K AF Shubitidze, Fridon Fernandez, Juan Pablo Shamatava, Irma Pasion, Leonard R. Barrowes, Benjamin E. O'Neill, Kevin TI Application of the Normalized Surface Magnetic Source Model to a Blind Unexploded Ordnance Discrimination Test SO APPLIED COMPUTATIONAL ELECTROMAGNETICS SOCIETY JOURNAL LA English DT Article; Proceedings Paper CT 25th International Review of Progress in Applied Computational Electromagnetics CY MAR 08-12, 2009 CL Monterey, CA DE UXO; Camp Sibert tests; NSMS model; HAP method; discrimination; inversion ID UXO DISCRIMINATION AB The Normalized Surface Magnetic Source (NSMS) model is applied to unexploded ordnance (UXO) discrimination data collected at Camp Sibert, AL, with the EM63 electromagnetic induction sensor. The NSMS is a fast and accurate numerical forward model that represents an object's response using a set of equivalent magnetic dipoles distributed on a surrounding closed surface. As part of the discrimination process one must also determine the location and orientation of each buried target. This is achieved using a physics-based technique that assumes a target to be a dipole and extracts the location from the measured magnetic field vector and the scalar magnetic potential; the latter is reconstructed from field measurements by means of an auxiliary layer of magnetic charges. Once the object's location is estimated, the measured magnetic field is matched to NSMS predictions to determine the time-dependent amplitudes of the surface magnetic sources, which in turn can be used to generate classifying features. This paper shows the superior discrimination performance of the NSMS model. C1 [Shubitidze, Fridon; Fernandez, Juan Pablo; Shamatava, Irma; Barrowes, Benjamin E.; O'Neill, Kevin] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Shamatava, Irma; Pasion, Leonard R.] Sky Res Inc, Vancouver, BC V6T 1Z3, Canada. [Barrowes, Benjamin E.; O'Neill, Kevin] USA, ERDC Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Shubitidze, F (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM fridon.shubitidze@dartmouth.edu; jpfb@dartmouth.edu; irma.shamatava@dartmouth.edu; len.pasion@skyresearch.com; benjatnin.e.barrowes@usace.army.mil; kevin.o'neill@erdc.usace.army.mil NR 21 TC 10 Z9 10 U1 0 U2 7 PU APPLIED COMPUTATIONAL ELECTROMAGNETICS SOC PI UNIVERSITY PA UNIV MISSISSIPPI, DEPT ELECTRICAL ENGINEERING, UNIVERSITY, MS 38677 USA SN 1054-4887 J9 APPL COMPUT ELECTROM JI Appl. Comput. Electromagn. Soc. J. PD JAN PY 2010 VL 25 IS 1 SI SI BP 89 EP 98 PG 10 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 589PN UT WOS:000277164600010 ER PT J AU Armistead-Jehle, P AF Armistead-Jehle, Patrick TI Symptom Validity Test Performance in U. S. Veterans Referred for Evaluation of Mild TBI SO APPLIED NEUROPSYCHOLOGY LA English DT Article DE mild TBI; MSVT; Symptom Validity Testing ID POSTTRAUMATIC-STRESS-DISORDER; PSYCHOGENIC NONEPILEPTIC SEIZURES; BASE RATES; NEUROPSYCHOLOGICAL TESTS; DISABILITY INCENTIVES; BRAIN-INJURY; EXAGGERATION; CLAIMANTS; FAILURE; FIBROMYALGIA AB The current study examined Medical Symptom Validity Test (MSVT) performance in U.S. veterans referred for evaluation of mild traumatic brain injury (TBI) after scoring positive on the Veterans Health Administration (VHA) TBI screening measures. Fifty-eight percent of the sample scored below the MSVT cut scores on subtests more sensitive to effort than to neurological insult. There were no differences among those who did and those who did not pass the MSVT as a function of gender, age, education, ethnicity, previous posttraumatic stress disorder or substance use disorder diagnoses, or Personality Assessment Inventory validity scales designed to measure negative impression management. A higher number of those who were service connected and previously diagnosed with a depressive condition failed the measure at a higher rate than those who were not. These results are discussed in relation to the specific nature of VHA patient populations. C1 [Armistead-Jehle, Patrick] Pacific Isl Hlth Care Syst, Dept Vet Affairs, Dept Mental Hlth, Honolulu, HI USA. RP Armistead-Jehle, P (reprint author), Munson Army Hlth Ctr, 550 Pope Ave, Ft Leavenworth, KS 66027 USA. EM patrick.jehle@armedd.army.mil NR 42 TC 76 Z9 76 U1 3 U2 6 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND SN 0908-4282 J9 APPL NEUROPSYCHOL JI Appl. Neuropsychol. PY 2010 VL 17 IS 1 BP 52 EP 59 AR PII 919154983 DI 10.1080/09084280903526182 PG 8 WC Clinical Neurology; Psychology SC Neurosciences & Neurology; Psychology GA 554JY UT WOS:000274432500007 PM 20146122 ER PT J AU Metcalfe, GD Shen, HG Wraback, M Koblmuller, G Gallinat, C Wu, F Speck, JS AF Metcalfe, Grace D. Shen, Hongen Wraback, Michael Koblmueller, Gregor Gallinat, Chad Wu, Feng Speck, James S. TI Terahertz Radiation from Nonpolar InN Due to Drift in an Intrinsic In-Plane Electric Field SO APPLIED PHYSICS EXPRESS LA English DT Article AB A sinusoidal dependence of the s- and p-polarized terahertz (THz) emission on sample rotation angle in m- and a-plane InN has been observed using ultrafast pulse excitation at a moderate pump fluence of similar to 1 mu J/cm(2). The angular dependence is attributed to carrier drift in an intrinsic in-plane electric field parallel to the c-axis induced by stacking fault-terminated internal polarization at wurtzite domain boundaries, with a THz polarity flip corresponding to a reversal of the c-axis. The p-polarized THz signal also consists of an angular-independent component, similar to that from c-plane InN, consistent with surface normal transport due to the photo-Dember effect. (c) 2010 The Japan Society of Applied Physics C1 [Metcalfe, Grace D.; Shen, Hongen; Wraback, Michael; Gallinat, Chad] USA, Res Lab, Sensors & Elect Devices Directorate, RDRL SEE M, Adelphi, MD 20783 USA. [Koblmueller, Gregor; Gallinat, Chad; Wu, Feng; Speck, James S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Koblmueller, Gregor] Tech Univ Munich, Walter Schottky Inst, D-85748 Garching, Germany. [Koblmueller, Gregor] Tech Univ Munich, Dept Phys, D-85748 Garching, Germany. RP Metcalfe, GD (reprint author), USA, Res Lab, Sensors & Elect Devices Directorate, RDRL SEE M, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM grace.metcalfe@us.army.mil RI Speck, James/H-5646-2011; Wu, Feng/D-5641-2015 NR 14 TC 11 Z9 11 U1 0 U2 7 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 1882-0778 EI 1882-0786 J9 APPL PHYS EXPRESS JI Appl. Phys. Express PY 2010 VL 3 IS 9 AR 092201 DI 10.1143/APEX.3.092201 PG 3 WC Physics, Applied SC Physics GA 653YY UT WOS:000282136500014 ER PT J AU Shatalov, M Sun, WH Bilenko, Y Sattu, A Hu, XH Deng, JY Yang, JW Shur, M Moe, C Wraback, M Gaska, R AF Shatalov, Max Sun, Wenhong Bilenko, Yuri Sattu, Ajay Hu, Xuhong Deng, Jianyu Yang, Jinwei Shur, Michael Moe, Craig Wraback, Michael Gaska, Remis TI Large Chip High Power Deep Ultraviolet Light-Emitting Diodes SO APPLIED PHYSICS EXPRESS LA English DT Article AB Single chip deep ultraviolet light-emitting diodes with junction area up to 1 mm(2) were fabricated for high power applications. Lateral geometry devices were designed for low operating voltage, uniform current spreading and emission resulting in substantial improvement of high current performance. The maximum CW optical power of 30 and 6 mW was achieved for devices emitting at 273 and 247 nm, respectively. (C) 2010 The Japan Society of Applied Physics C1 [Shatalov, Max; Sun, Wenhong; Bilenko, Yuri; Sattu, Ajay; Hu, Xuhong; Deng, Jianyu; Yang, Jinwei; Shur, Michael; Gaska, Remis] Sensor Elect Technol Inc, Columbia, SC 29209 USA. [Shur, Michael] Rensselaer Polytech Inst, Dept Elect Comp & Syst Engn, Troy, NY 12180 USA. [Shur, Michael] Rensselaer Polytech Inst, Ctr Integrated Elect, Troy, NY 12180 USA. [Moe, Craig; Wraback, Michael] USA, Res Lab, Adelphi, MD 20783 USA. RP Shatalov, M (reprint author), Sensor Elect Technol Inc, 1195 Atlas Rd, Columbia, SC 29209 USA. EM shatalov@s-et.com RI Shur, Michael/A-4374-2016 OI Shur, Michael/0000-0003-0976-6232 FU U.S. Army Research Office [W911NF-09-C-0160]; U.S. Army Research Laboratory [W911NF-07-2-0057, W911NF-10-2-0023] FX This work was partially supported by the U.S. Army Research Office SBIR Phase II contract W911NF-09-C-0160 (Dr. Michael Gerhold) and U.S. Army Research Laboratory Cooperative Research Agreements W911NF-07-2-0057 and W911NF-10-2-0023 (Dr. Michael Wraback). NR 17 TC 18 Z9 18 U1 1 U2 9 PU JAPAN SOC APPLIED PHYSICS PI TOKYO PA KUDAN-KITA BUILDING 5TH FLOOR, 1-12-3 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN SN 1882-0778 J9 APPL PHYS EXPRESS JI Appl. Phys. Express PY 2010 VL 3 IS 6 AR 062101 DI 10.1143/APEX.3.062101 PG 3 WC Physics, Applied SC Physics GA 613ES UT WOS:000278961400014 ER PT J AU Kannarpady, GK Sharma, R Liu, B Trigwell, S Ryerson, C Biris, AS AF Kannarpady, Ganesh K. Sharma, Rajesh Liu, Bo Trigwell, Steve Ryerson, Charles Biris, Alexandru S. TI Silane decorated metallic nanorods for hydrophobic applications SO APPLIED SURFACE SCIENCE LA English DT Article DE Silane decoration; Hydrophobicity; Anti-icing coating; Metallic nanorods ID GLANCING-ANGLE DEPOSITION; SUPERHYDROPHOBIC SURFACE; ALUMINUM; WATER; NANOPARTICLES; LITHOGRAPHY; WETTABILITY; FABRICATION; FILMS AB A novel technique to modify a metallic surface for anti-icing applications is presented. An oblique angle deposition (OAD) technique has been used to fabricate metallic nanorods of Aluminum and Tungsten on a glass substrate. A conformal coating of a silane has been applied using a molecular vapor deposition technique. The resulting surface has shown a static contact angle of 134 degrees with the water droplet. SEM, AFM and XPS have been used to study the surface modification. This is a highly promising approach for anti-icing applications due to its scalability at a very low cost. (C) 2009 Elsevier B.V. All rights reserved. C1 [Kannarpady, Ganesh K.; Sharma, Rajesh; Liu, Bo; Biris, Alexandru S.] Univ Arkansas, Nanotechnol Ctr, Little Rock, AR 72204 USA. [Trigwell, Steve] ASRC Aerosp, Kennedy Space Ctr, FL 32899 USA. [Ryerson, Charles] USA, Terr & Cryospher Sci Branch, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr,Corps Engineers, Hanover, NH 03755 USA. RP Kannarpady, GK (reprint author), Univ Arkansas, Nanotechnol Ctr, 2801 S Univ Ave, Little Rock, AR 72204 USA. EM gkkannarpady@ualr.edu; asbiris@ualr.edu RI Biris, Alexandru/A-8507-2010 FU Arkansas Science & Technology Authority [08-CAT-03]; U.S. Army [W912HZ-09-02-0008] FX Financial support from Arkansas Science & Technology Authority (Grant #08-CAT-03) and U.S. Army (ERDC Cooperative Agreement Number: W912HZ-09-02-0008) is greatly acknowledged. NR 21 TC 22 Z9 23 U1 2 U2 19 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-4332 J9 APPL SURF SCI JI Appl. Surf. Sci. PD JAN 1 PY 2010 VL 256 IS 6 BP 1679 EP 1682 DI 10.1016/j.apsusc.2009.09.093 PG 4 WC Chemistry, Physical; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Chemistry; Materials Science; Physics GA 537YZ UT WOS:000273151900011 ER PT J AU James, WF AF James, William F. TI Nitrogen retention in a floodplain backwater of the upper Mississippi River (USA) SO AQUATIC SCIENCES LA English DT Article DE Ammonium; Backwaters; Denitrification; Nitrification; Nitrate; Rivers ID GULF-OF-MEXICO; AQUATIC ECOSYSTEMS; DENITRIFICATION; NITRATE; NITRIFICATION; RATES; SEDIMENT; STREAMS; MACROPHYTE; DANUBE AB Backwaters connected to large rivers retain nitrate and may play an important role in reducing downstream loading to coastal marine environments. A summer nitrogen (N) inflow-outflow budget was examined for a flow-regulated backwater of the upper Mississippi River in conjunction with laboratory estimates of sediment ammonium and nitrate fluxes, organic N mineralization, nitrification, and denitrification to provide further insight into N retention processes. External N loading was overwhelmingly dominated by nitrate and 54% of the input was retained (137 mg m(-2) day(-1)). Ammonium and dissolved organic N were exported from the backwater (14 and 9 mg m(-2) day(-1), respectively). Nitrate influx to sediment increased as a function of increasing initial nitrate concentration in the overlying water. Rates were greater under anoxic versus oxic conditions. Ammonium effluxes from sediment were 26.7 and 50.6 mg m(-2) day(-1) under oxic and anoxic conditions, respectively. Since anoxia inhibited nitrification, the difference between ammonium anoxic-oxic fluxes approximated a nitrification rate of 29.1 mg m(-2) day(-1). Organic N mineralization was 64 mg m(-2) day(-1). Denitrification, estimated from regression relationships between oxic nitrate influx versus initial nitrate concentration and a summer lakewide mean nitrate concentration of 1.27 mg l(-1), was 94 mg m(-2) day(-1). Denitrification was equivalent to only 57% of the retained nitrate, suggesting that another portion was assimilated by biota. The high sediment organic N mineralization and ammonium efflux rate coupled with the occurrence of ammonium export from the system suggested a possible link between biotic assimilation of nitrate, mineralization, and export. C1 US Army Corps Engineers, Engineer Res & Dev Ctr, Eau Galle Aquat Ecol Lab, Spring Valley, WI 54767 USA. RP James, WF (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Eau Galle Aquat Ecol Lab, W500 Eau Galle Dam Rd, Spring Valley, WI 54767 USA. EM william.f.james@usace.army.mil FU U.S. Army Corps of Engineers; Engineer Research and Development Center; System-Wide Water Resources Program FX Funding was provided by the U.S. Army Corps of Engineers, Engineer Research and Development Center, System-Wide Water Resources Program. H. Eakin and L. Pommier of the Eau Galle Aquatic Ecology Laboratory are gratefully acknowledged for their participation in this research. Permission to publish this information was granted by the Chief of Engineers. NR 32 TC 8 Z9 10 U1 1 U2 10 PU BIRKHAUSER VERLAG AG PI BASEL PA VIADUKSTRASSE 40-44, PO BOX 133, CH-4010 BASEL, SWITZERLAND SN 1015-1621 J9 AQUAT SCI JI Aquat. Sci. PD JAN PY 2010 VL 72 IS 1 BP 61 EP 69 DI 10.1007/s00027-009-0113-3 PG 9 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 534MN UT WOS:000272901900006 ER PT J AU Yeh, S Forooghian, F Wong, WT Faia, LJ Cukras, C Lew, JC Wroblewski, K Weichel, ED Meyerle, CB Sen, HN Chew, EY Nussenblatt, RB AF Yeh, Steven Forooghian, Farzin Wong, Wai T. Faia, Lisa J. Cukras, Catherine Lew, Julie C. Wroblewski, Keith Weichel, Eric D. Meyerle, Catherine B. Sen, Hatice Nida Chew, Emily Y. Nussenblatt, Robert B. TI Fundus Autofluorescence Imaging of the White Dot Syndromes SO ARCHIVES OF OPHTHALMOLOGY LA English DT Article ID OCCULT OUTER RETINOPATHY; RELENTLESS PLACOID CHORIORETINITIS; RETINAL-PIGMENT EPITHELIUM; SERPIGINOUS CHOROIDITIS; MACULAR DEGENERATION; GEOGRAPHIC ATROPHY; PROGRESSION; LIPOFUSCIN; ENTITY AB Objective: To characterize the fundus autofluorescence (FAF) findings in patients with white dot syndromes (WDSs). Methods: Patients with WDSs underwent ophthalmic examination, fundus photography, fluorescein angiography, and FAF imaging. Patients were categorized as having no, minimal, or predominant foveal hypoautofluorescence. The severity of visual impairment was then correlated with the degree of foveal hypoautofluorescence. Results: Fifty-five eyes of 28 patients with WDSs were evaluated. Visual acuities ranged from 20/12.5 to hand motions. Diagnoses included serpiginous choroidopathy (5 patients), birdshot retinochoroidopathy (10), multifocal choroiditis (8), relentless placoid chorioretinitis (1), presumed tuberculosis-associated serpiginouslike choroidopathy (1), acute posterior multifocal placoid pigment epitheliopathy (1), and acute zonal occult outer retinopathy (2). In active serpiginous choroidopathy, notable hyperautofluorescence in active disease distinguished it from the variegated FAF features of tuberculosis-associated serpiginouslike choroidopathy. The percentage of patients with visual acuity impairment of less than 20/40 differed among eyes with no, minimal, and predominant foveal hypoautofluorescence (P<.001). Patients with predominant foveal hypoautofluorescence demonstrated worse visual acuity than those with minimal or no foveal hypoautofluorescence (both P<.001). Conclusions: Fundus autofluorescence imaging is useful in the evaluation of the WDS. Visual acuity impairment is correlated with foveal hypoautofluorescence. Further studies are needed to evaluate the precise role of FAF imaging in the WDSs. C1 [Yeh, Steven; Forooghian, Farzin; Wong, Wai T.; Faia, Lisa J.; Cukras, Catherine; Lew, Julie C.; Wroblewski, Keith; Weichel, Eric D.; Meyerle, Catherine B.; Sen, Hatice Nida; Chew, Emily Y.; Nussenblatt, Robert B.] NEI, NIH, Bethesda, MD 20892 USA. [Wroblewski, Keith; Weichel, Eric D.] Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. RP Nussenblatt, RB (reprint author), NEI, NIH, 10 Ctr Dr,Bldg 10,10N-112, Bethesda, MD 20892 USA. EM DrBob@nei.nih.gov RI Wong, Wai/B-6118-2017 OI Wong, Wai/0000-0003-0681-4016 FU National Eye Institute; National Institutes of Health; Heed Ophthalmic Foundation FX This study was supported in part by Intramural Funding of the National Eye Institute, National Institutes of Health, and the Heed Ophthalmic Foundation (Dr Yeh). NR 28 TC 28 Z9 30 U1 1 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-9950 J9 ARCH OPHTHALMOL-CHIC JI Arch. Ophthalmol. PD JAN PY 2010 VL 128 IS 1 BP 46 EP 56 DI 10.1001/archophthalmol.2009.368 PG 11 WC Ophthalmology SC Ophthalmology GA 542XO UT WOS:000273532800006 PM 20065216 ER PT J AU Laucirica, R Bentz, JS Souers, RJ Wasserman, PG Crothers, BA Clayton, AC Henry, MR Chmara, BA Clary, KM Fraig, MM Moriarty, AT AF Laucirica, Rodolfo Bentz, Joel S. Souers, Rhona J. Wasserman, Patricia G. Crothers, Barbara A. Clayton, Amy C. Henry, Michael R. Chmara, Beth Anne Clary, Karen M. Fraig, Mostafa M. Moriarty, Ann T. TI Do Liquid-Based Preparations of Urinary Cytology Perform Differently Than Classically Prepared Cases? Observations From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID TRANSITIONAL-CELL-CARCINOMA; IN-SITU HYBRIDIZATION; THIN-LAYER; GYNECOLOGIC CYTOLOGY; BLADDER; DIAGNOSIS; THINPREP(R) AB Context.-The cytomorphology of liquid-based preparations in urine cytology is different than classic slide preparations. Objectives.-To compare the performance of liquid-based preparation specimens to classically prepared urine specimens with a malignant diagnosis in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Design.-Participant responses between 2000 and 2007 for urine specimens with a reference diagnosis of high-grade urothelial carcinoma/carcinoma in situ/dysplasia (HGUCA), squamous cell carcinoma, or adenocarcinoma were evaluated. ThinPrep and SurePath challenges were compared with classic preparations (smears, cytospins) for discordant responses. Results.-There were 18 288 pathologist, 11 957 cytotechnologist, and 8086 "laboratory'' responses available. Classic preparations comprised 90% (n = 34 551) of urine challenges; 9% (n = 3295) were ThinPrep and 1% (n = 485) were SurePath. Concordance to the general category of "positive-malignant'' was seen in 92% of classic preparations, 96.5% of ThinPrep, and 94.6% of SurePath challenges (P < .001). These results were statistically different for the exact reference interpretation of HGUCA (P < .001) but not for adenocarcinoma (P = .22). Cytotechnologists demonstrate statistically better performance for the general category of "positive-malignant'' compared with pathologists for all urinary slide types and for the exact reference interpretation of HGUCA (94% versus 91.1%; P < .001) but not adenocarcinoma (96.3% versus 95.8%; P = .77) or squamous cell carcinoma (93.6% versus 87.7%; P = .07). Conclusions.-Liquid-based preparations performed significantly better in urinary cytology challenges when evaluating malignant categories in the College of American Pathologists interlaboratory comparison program. The liquid-based preparation challenges also performed better for the exact reference interpretation of HGUCA, but no difference was observed for adenocarcinoma challenges. Cytotechnologists perform better than pathologists for all slide types, as well as those demonstrating HGUCA. These results suggest that liquid-based preparations facilitate a more accurate diagnosis than conventional preparations. (Arch Pathol Lab Med. 2010; 134: 19-22) C1 [Laucirica, Rodolfo] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA. [Bentz, Joel S.] Univ Utah, Dept Pathol, Salt Lake City, UT USA. [Souers, Rhona J.] Coll Amer Pathologists, Dept Biostat, Northfield, IL USA. [Chmara, Beth Anne] Coll Amer Pathologists, Surveys Dept, Northfield, IL USA. [Wasserman, Patricia G.] Long Isl Jewish Med Ctr, Dept Pathol, New Hyde Pk, NY 11042 USA. [Crothers, Barbara A.] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. [Clayton, Amy C.; Henry, Michael R.] Mayo Clin, Rochester, MN USA. [Clary, Karen M.] Rochester Gen Hosp, Dept Pathol, Rochester, NY 14621 USA. [Fraig, Mostafa M.] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. [Moriarty, Ann T.] AmeriPath Indiana, Indianapolis, IN USA. RP Laucirica, R (reprint author), Baylor Coll Med, Dept Pathol, 1 Baylor Plaza, Houston, TX 77030 USA. EM rodolfol@bcm.edu RI Fraig, Mostafa/I-1670-2016 OI Fraig, Mostafa/0000-0003-1119-3672 NR 23 TC 14 Z9 16 U1 0 U2 2 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD JAN PY 2010 VL 134 IS 1 BP 19 EP 22 PG 4 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA 542ZV UT WOS:000273539400005 PM 20073599 ER PT J AU Hebert, JJ Koppenhaver, SL Magel, JS Fritz, JM AF Hebert, Jeffrey J. Koppenhaver, Shane L. Magel, John S. Fritz, Julie M. TI The Relationship of Transversus Abdominis and Lumbar Multifidus Activation and Prognostic Factors for Clinical Success With a Stabilization Exercise Program: A Cross-Sectional Study SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE Exercise; Low back pain; Muscle, skeletal; Prognosis; Rehabilitation; Ultrasonography ID LOW-BACK-PAIN; FEEDFORWARD POSTURAL RESPONSES; TRUNK MUSCLES; ULTRASOUND MEASUREMENT; PARASPINAL MUSCLES; DISC HERNIATION; DRAWING-IN; LOWER-LIMB; CONTRACTION; RELIABILITY AB Hebert JJ, Koppenhaver SL, Magel JS, Fritz JM. The relationship of transversus abdominis and lumbar multifidus activation and prognostic factors for clinical success with a stabilization exercise program: a cross-sectional study. Arch Phys Med Rehabil 2010;91:78-85. Objective: To examine the relationship between prognostic factors for clinical success with a stabilization exercise program and lumbar multifidus (LM) and transversus abdominis (TrA) muscle activation assessed using rehabilitative ultrasound imaging (RUSI). Design: Cross-sectional study. Setting: Outpatient physical therapy clinic. Participants: Volunteers with current low back pain (N=40). Intervention: Not applicable. Main Outcome Measures: We examined the relationship between prognostic factors associated with clinical success with a stabilization exercise program (positive prone instability test, age <40y, aberrant movements, straight leg raise >91 degrees, presence of lumbar hypermobility) and degree of TrA and LM muscle activation assessed by RUSI. Results: Significant univariate relationships were identified between LM muscle activation and the number of prognostic factors present (Pearson correlation coefficient [r] = -.558, P=.001), as well as the individual factors of a positive prone instability test (point biserial correlation coefficient [r(pbis)]=.376, P=.018) and segmental hypermobility (r(pbis) = .358, P=.025). The multivariate analyses indicated that after controlling for other variables, the addition of the variable "number of prognostic factors present" resulted in a significant increase in R(2) (P=.006). No significant univariate or multivariate relationships were observed between the prognostic factors and TrA muscle activation. Conclusions: Decreased LM muscle activation, but not TrA muscle activation, is associated with the presence of factors predictive of clinical success with a stabilization exercise program. Our findings provide researchers and clinicians with evidence regarding the construct validity of the prognostic factors examined in this study, as well as the potential clinical importance of the LM muscle as a target for stabilization exercises. C1 [Hebert, Jeffrey J.; Koppenhaver, Shane L.; Magel, John S.; Fritz, Julie M.] Univ Utah, Coll Hlth, Salt Lake City, UT USA. [Magel, John S.; Fritz, Julie M.] Intermt Healthcare, Salt Lake City, UT USA. [Koppenhaver, Shane L.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. RP Hebert, JJ (reprint author), Dept Phys Therapy, 520 Wakara Way, Salt Lake City, UT 84108 USA. EM jeff.hebert@utah.edu RI Hebert, Jeffrey/C-4614-2008; OI Hebert, Jeffrey/0000-0002-6959-325X; Magel, John/0000-0001-9087-4753 FU Sonosite Inc FX Supported in part by Sonosite Inc. Bothell, WA, in providing the ultrasound machine used in this study to the Department of Physical Therapy, University of Utah. NR 59 TC 24 Z9 27 U1 3 U2 25 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JAN PY 2010 VL 91 IS 1 BP 78 EP 85 DI 10.1016/j.apmr.2009.08.146 PG 8 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 592YG UT WOS:000277417300012 PM 20103400 ER PT J AU Kraft, TL Jobes, DA Lineberry, TW Conrad, A Kung, S AF Kraft, Tara L. Jobes, David A. Lineberry, Timothy W. Conrad, Amy Kung, Simon TI Brief Report: Why Suicide? Perceptions of Suicidal Inpatients and Reflections of Clinical Researchers SO ARCHIVES OF SUICIDE RESEARCH LA English DT Article DE qualitative research; suicidal ideation; suicide ID SOCIAL DESIRABILITY; HOPELESSNESS; PARASUICIDE AB Qualitatively oriented research (e.g., studies of suicide notes) has shed valuable light on the phenomenology of suicidal states. However, one draw back to this approach is that conclusions drawn from such data are inferential. In the current study, we took a more direct approach by having a sample of 52 suicidal inpatients provide written responses to the following query: Why suicide? A reliable coding system was developed that captured seven distinct response types to our prompt (i.e., suicide was seen as: the easy way out, a permanent solution, an escape from pain, the only option, self-oriented, related to hopelessness, and relationally-focused). In our discussion, we further reflect on these patient perceptions of suicide in terms of theory, research, and practice. C1 [Kraft, Tara L.; Jobes, David A.] Catholic Univ Amer, Dept Psychol, Washington, DC 20064 USA. [Lineberry, Timothy W.; Kung, Simon] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA. [Conrad, Amy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Kraft, TL (reprint author), Univ Kansas, Dept Psychol, 1415 Jayhawk Blvd, Lawrence, KS 66045 USA. EM kraft.tara@gmail.com NR 22 TC 10 Z9 10 U1 1 U2 4 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 1381-1118 J9 ARCH SUICIDE RES JI Arch. Suicide Res. PY 2010 VL 14 IS 4 BP 375 EP 382 AR PII 929635274 DI 10.1080/13811118.2010.524073 PG 8 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA 680HE UT WOS:000284222200007 PM 21082453 ER PT J AU Hajjar, RM AF Hajjar, Remi M. TI A New Angle on the US Military's Emphasis on Developing Cross-Cultural Competence: Connecting In-Ranks' Cultural Diversity to Cross-Cultural Competence SO ARMED FORCES & SOCIETY LA English DT Article DE cross-cultural competence; culture-general factors; culture-specific factors; internal cultural diversity issues AB This article forwards a novel approach regarding the U.S. military's growing focus on building cross-cultural competence. This piece argues that a link exists between the armed forces' internal cultural diversity issues and the military's objective to heighten its ability to work effectively in foreign cultures. Cross-cultural competence means the knowledge, attitudes, and behavioral repertoire and skill sets that military members require to accomplish all given tasks and missions involving cultural diversity. Despite the military's noteworthy historic progress in the area of building a diverse and cohesive force, it possesses some ongoing cultural diversity problems. The article examines three concerns within the ranks of the U.S. military: signs of religious intolerance, some ongoing resistance toward women service members, and antihomosexual attitudes and conduct. This piece explores these concerns and also argues that ameliorating these cultural diversity issues will contribute to building cross-cultural competence in the military. C1 USA, Washington, DC USA. RP Hajjar, RM (reprint author), USA, Washington, DC USA. EM remi.hajjar@us.army.mil NR 26 TC 11 Z9 11 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X EI 1556-0848 J9 ARMED FORCES SOC JI Armed Forces Soc. PD JAN PY 2010 VL 36 IS 2 BP 247 EP 263 DI 10.1177/0095327X09339898 PG 17 WC Political Science; Sociology SC Government & Law; Sociology GA 535CS UT WOS:000272944800003 ER PT J AU Campbell, DJ Campbell, KM AF Campbell, Donald J. Campbell, Kathleen M. TI Soldiers as Police Officers Police Officers as Soldiers: Role Evolution and Revolution in the United States SO ARMED FORCES & SOCIETY LA English DT Article DE role convergence; police-military fusion; military job redefinition AB The military and police professions share a number of common facets, but in spite of surface similarities, the two professions are significantly different. Consequently, the evidence indicating a convergence of primary aspects of the two roles presages an important societal development, with substantial implications on several levels. Thus, this article has several objectives. First, it reviews the evidence indicating role convergence, that is, evidence that significant segments of police operations in the United States have taken on military characteristics; and evidence indicating that many U.S. military initiatives have taken on policing characteristics. Next, using the notion of internal and external role-change "drivers," it examines how such role shifts occur and considers some political and legal implications of the shift. Third, the article compares the role orientations and job demands of both professions, identifying the important differences inherent in the two roles and presenting an analysis of the occupational implications of role convergence for job holders, job evaluators, and job "clients" (i.e., ordinary citizens). The last section considers the implications of role convergence for role management. C1 [Campbell, Donald J.; Campbell, Kathleen M.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Campbell, DJ (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. NR 32 TC 7 Z9 7 U1 0 U2 6 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD JAN PY 2010 VL 36 IS 2 BP 327 EP 350 DI 10.1177/0095327X09335945 PG 24 WC Political Science; Sociology SC Government & Law; Sociology GA 535CS UT WOS:000272944800007 ER PT J AU Fowler, J Owens, BD AF Fowler, Justin Owens, Brett D. TI Abdominal Compartment Syndrome After Hip Arthroscopy SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY LA English DT Article ID JOINT AB As hip arthroscopy becomes a more common procedure, more complications may occur. We present a case of abdominal compartment syndrome resulting from fluid extravasation in a 42-year-old man who underwent routine hip arthroscopy for femoral acetabular impingement. He had not had previous surgeries to that hip, and arthroscopy was performed in the supine position. After adequate distraction, arthroscopy was performed with an automated pressure-and flow-controlled pump with the pressure maintained between 40 and 60 mm Hg. We performed debridement of a degenerative tear of the anterosuperior labrum, removal of a pincer lesion, and a psoas tenotomy through a capsular window. A distended abdomen was noted on drape removal, and the patient required decompressive laparotomy for abdominal compartment syndrome. Extravasation of arthroscopy fluid is a potentially devastating complication during hip arthroscopy, and there should be careful monitoring by the surgeons, anesthesiologists, and operating room staff. C1 [Fowler, Justin; Owens, Brett D.] William Beaumont Army Med Ctr, Div Orthopaed Surg, El Paso, TX 79920 USA. RP Owens, BD (reprint author), Keller Army Hosp, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 9 TC 37 Z9 38 U1 1 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0749-8063 J9 ARTHROSCOPY JI Arthroscopy PD JAN PY 2010 VL 26 IS 1 BP 128 EP 130 DI 10.1016/j.arthro.2009.06.021 PG 3 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 552NT UT WOS:000274299700018 PM 20117637 ER PT S AU Fanelli, RL AF Fanelli, Robert L. BE Hart, E McEwan, C Timmis, J Hone, A TI Further Experimentation with Hybrid Immune Inspired Network Intrusion Detection SO ARTIFICIAL IMMUNE SYSTEMS SE Lecture Notes in Computer Science LA English DT Proceedings Paper CT 9th International Conference on Artificial Immune Systems (ICARIS 2010) CY JUL 26-29, 2010 CL Edinburgh, SCOTLAND SP Pervas Adaptat Network, Inst Informat & Digital Innovat ID ANOMALY DETECTION; DANGER; SYSTEM AB This paper presents continued experimentation on the Network Threat Recognition with Immune Inspired Anomaly Detection, or NetTRIIAD, model. This hybrid model combines established network monitoring methods with artificial immune system methods to achieve improved performance. The paper presets experiments investigating the model's performance in detecting novel threats and the performance contribution of the individual components. C1 US Mil Acad, West Point, NY 10996 USA. RP Fanelli, RL (reprint author), US Mil Acad, West Point, NY 10996 USA. EM robert.fanelli@usma.edu NR 24 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0302-9743 BN 978-3-642-14546-9 J9 LECT NOTES COMPUT SC PY 2010 VL 6209 BP 264 EP 275 PG 12 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Computer Science, Theory & Methods SC Computer Science GA BSS43 UT WOS:000285700300021 ER PT B AU Corum, JS AF Corum, James S. BE Kassimeris, G Buckley, J TI Development of Modern Counterinsurgency Theory and Doctrine SO ASHGATE RESEARCH COMPANION TO MODERN WARFARE LA English DT Article; Book Chapter C1 Balt Def Coll, Tartu, Estonia. [Corum, James S.] US Army Reserve, Ft Bragg, NC USA. RP Corum, JS (reprint author), Balt Def Coll, Tartu, Estonia. NR 37 TC 1 Z9 1 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-0-7546-9177-8; 978-0-7546-7410-8 PY 2010 BP 31 EP 48 PG 18 WC International Relations; Political Science SC International Relations; Government & Law GA BA3RX UT WOS:000334697000004 ER PT B AU Chun, C AF Chun, Clayton BE Pauly, RJ TI The Greater Middle East SO ASHGATE RESEARCH COMPANION TO US FOREIGN POLICY LA English DT Article; Book Chapter C1 US Army War Coll, Dept Distance Educ, Carlisle, PA 17013 USA. RP Chun, C (reprint author), US Army War Coll, Dept Distance Educ, Carlisle, PA 17013 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASHGATE PUBLISHING LTD PI ALDERSHOT PA GOWER HOUSE, CROFT ROAD, ALDERSHOT GU11 3HR, ENGLAND BN 978-0-7546-9932-3; 978-0-7546-4862-8 PY 2010 BP 159 EP 174 PG 16 WC International Relations SC International Relations GA BA3ML UT WOS:000334361400010 ER PT S AU Zhu, DM Taylor, AJ Villines, TC AF Zhu, Daming Taylor, Allen J. Villines, Todd C. BE Naghavi, M TI Monitoring of Subclinical Atherosclerotic Disease SO ASYMPTOMATIC ATHEROSCLEROSIS: PATHOPHYSIOLOGY, DETECTION AND TREATMENT SE Contemporary Cardiology LA English DT Article; Book Chapter DE Atherosclerosis; Carotid artery; Coronary calcium; Inflammation; Risk factors; Computed tomography; Clinical trials ID CORONARY-ARTERY CALCIUM; POSITRON-EMISSION-TOMOGRAPHY; INTIMA-MEDIA THICKNESS; ELECTRON-BEAM CT; SPIRAL COMPUTED-TOMOGRAPHY; RANDOMIZED CONTROLLED-TRIAL; LIPID-LOWERING THERAPY; IN-VIVO; PLAQUE INFLAMMATION; CAROTID INTIMA AB Direct assessment of the vascular wall provides the capability to monitor atherosclerosis progression and assess the response to pharmacotherapy as a surrogate to clinical outcomes. Carotid intima-media thickness (IMT) using high-frequency ultrasound (10 MHz) accurately measures arterial wall thickness, with the recommendation that the far wall of the common carotid artery is the optimal site for serial assessment. A 15-18% increase in relative risk for myocardial infarction and stroke is observed for each 0.10 mm increase in carotid IMT. Inter-test reproducibility is high, but the application to individual patients is limited by generally slow progression of IMT. Coronary artery calcium correlates to overall atherosclerosis burden and independently predicts incident cardiovascular events up to tenfold over standard risk factors. Progression of coronary calcium is rapid, and a rate >= 15% per year clinically identifies individuals with increased cardiovascular risk. A complicated relationship exists between cardiovascular risk factor modification and coronary calcium progression, such that its use in pharmacotherapy evaluation is limited. Contrast enhanced CT angiography provides the ability to image both calcified and non-calcified coronary atherosclerosis, but requires careful attention to image quality. Nuclear imaging of the vascular wall, with positron emission tomography, targets inflammation within the vascular wall of larger vessels. Pharmacotherapies with anti-inflammatory properties may be studied with FDG-PET, but these findings have not yet been related to cardiovascular outcomes. C1 [Zhu, Daming] Johns Hopkins Bayview Med Ctr, Dept Internal Med, Baltimore, MD USA. [Taylor, Allen J.; Villines, Todd C.] USA, Serv Cardiol, Walter Reed Army Med Ctr, Washington, DC 20310 USA. RP Zhu, DM (reprint author), Johns Hopkins Bayview Med Ctr, Dept Internal Med, Baltimore, MD USA. NR 79 TC 0 Z9 0 U1 0 U2 0 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA SN 1191-7601 BN 978-1-60327-178-3 J9 CONTEMP CARDIOL JI Contemp. Cardiol. PY 2010 BP 549 EP 567 DI 10.1007/978-1-60327-179-0_41 D2 10.1007/978-1-60327-179-0 PG 19 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA BOC89 UT WOS:000276203100041 ER PT B AU Webster, GD Walter, JR AF Webster, George D. Walter, Jack R. BE Staskin, DR TI Artificial Urinary Sphincter II SO ATLAS OF BLADDER DISEASE LA English DT Article; Book Chapter ID INCONTINENCE C1 [Webster, George D.] Duke Univ, Med Ctr, Dept Surg, Div Urol, Durham, NC 27710 USA. [Walter, Jack R.] Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. RP Webster, GD (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Urol, Durham, NC 27710 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-57340-307-8 PY 2010 BP 201 EP 207 PG 7 WC Surgery; Urology & Nephrology SC Surgery; Urology & Nephrology GA BMM82 UT WOS:000272856800013 ER PT J AU Knepp, TN Bottenheim, J Carlsen, M Carlson, D Donohoue, D Friederich, G Matrai, PA Netcheva, S Perovich, DK Santini, R Shepson, PB Simpson, W Valentic, T Williams, C Wyss, PJ AF Knepp, T. N. Bottenheim, J. Carlsen, M. Carlson, D. Donohoue, D. Friederich, G. Matrai, P. A. Netcheva, S. Perovich, D. K. Santini, R. Shepson, P. B. Simpson, W. Valentic, T. Williams, C. Wyss, P. J. TI Development of an autonomous sea ice tethered buoy for the study of ocean-atmosphere-sea ice-snow pack interactions: the O-buoy SO ATMOSPHERIC MEASUREMENT TECHNIQUES LA English DT Article ID SURFACE OZONE DEPLETION; POLAR SUNRISE; FROST FLOWERS; BROMINE; AIR; BRO; CHEMISTRY; CO2; DESTRUCTION; VARIABILITY AB A buoy based instrument platform (the "O-buoy") was designed, constructed, and field tested for year-round measurement of ozone, bromine monoxide, carbon dioxide, and meteorological variables over Arctic sea ice. The O-buoy operated in an autonomous manner with daily, bi-directional data transmissions using Iridium satellite communication. The O-buoy was equipped with three power sources: primary lithium-ion battery packs, rechargeable lead acid packs, and solar panels that recharge the lead acid packs, and can fully power the O-buoy during summer operation. This system was designed to operate under the harsh conditions present in the Arctic, with minimal direct human interaction, to aid in our understanding of the atmospheric chemistry that occurs in this remote region of the world. The current design requires approximately yearly maintenance limited by the lifetime of the primary power supply. The O-buoy system was field tested in Elson Lagoon, Barrow, Alaska from February to May 2009, and deployed in the Beaufort Sea in October 2009. Here, we describe the design and present preliminary data. C1 [Matrai, P. A.] Bigelow Lab Ocean Sci, W Boothbay Harbor, ME 04575 USA. [Knepp, T. N.; Shepson, P. B.] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA. [Bottenheim, J.; Netcheva, S.] Environm Canada, Toronto, ON M3H 5T4, Canada. [Carlsen, M.; Santini, R.; Wyss, P. J.] Purdue Univ, Jonathan Amy Facil Chem Instrumentat, W Lafayette, IN 47907 USA. [Carlson, D.; Donohoue, D.; Simpson, W.] Univ Alaska Fairbanks, Dept Chem & Biochem, Fairbanks, AK 99775 USA. [Friederich, G.] Monterey Bay Aquarium Res Inst, Moss Landing, CA 95039 USA. [Perovich, D. K.] USA, Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Shepson, P. B.; Williams, C.] Purdue Univ, Dept Earth & Atmospher Sci, W Lafayette, IN 47907 USA. [Shepson, P. B.] Purdue Univ, Purdue Climate Change Res Ctr, W Lafayette, IN 47909 USA. [Valentic, T.] SRI Int, Menlo Pk, CA 94025 USA. RP Matrai, PA (reprint author), Bigelow Lab Ocean Sci, 180 McKown Pt, W Boothbay Harbor, ME 04575 USA. EM pmatrai@bigelow.org RI Shepson, Paul/E-9955-2012; Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 FU NSF [ARC-0612331, ARC-0611992, ARC-0612047, ARC-0612457]; Canadian Government's Federal Program Office for the International Polar FX We thank the NSF for funding this work through grants No. ARC-0612331, ARC-0611992, ARC-0612047, and ARC-0612457 to P. Matrai, D. Perovich, P. Shepson, and W. Simpson, respectively, and the Canadian Government's Federal Program Office for the International Polar Year No. MD065, "OASIS-CANADA". NR 44 TC 13 Z9 14 U1 0 U2 6 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1867-1381 EI 1867-8548 J9 ATMOS MEAS TECH JI Atmos. Meas. Tech. PY 2010 VL 3 IS 1 BP 249 EP 261 PG 13 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 602DK UT WOS:000278118500017 ER PT S AU Klipp, C AF Klipp, Cheryl BE Thomas, LMW Spillar, EJ TI Near-surface anisotropic turbulence SO ATMOSPHERIC PROPAGATION VII SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Atmospheric Propagation VII CY APR 06-07, 2010 CL Orlando, FL SP SPIE DE Anisotropic turbulence; Reynolds stress tensor; multiresolution decomposition; Haar wavelet; CASES99 data AB Turbulent motion is nearly isotropic at spatial scales on the order of a few meters or less, but larger scales, which carry more energy, are anisotropic. It is found that the scales of peak contribution to the total turbulent kinetic energy vary from 50 to 5000 meters depending on stability and elevation above the surface. The scales of peak contribution to the heat flux vary 2 meters to 1000 meters depending on stability and elevation above the surface. The temperature variance shows little contribution at night for scales between a few meters and a few kilometers, while daytime peak temperature variances occur at scales on the order of 100 meters to 2000 meters depending on elevation. Also, the natural coordinate system for the turbulent motion is not aligned with the streamwise, cross-stream, vertical coordinate system and varies with the scale of the motion as well as stability. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Klipp, C (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM cheryl.l.klipp@us.army.mil NR 7 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8149-8 J9 P SOC PHOTO-OPT INS PY 2010 VL 7685 AR 768505 DI 10.1117/12.849557 PG 11 WC Mechanics; Meteorology & Atmospheric Sciences; Optics SC Mechanics; Meteorology & Atmospheric Sciences; Optics GA BSM44 UT WOS:000284932600004 ER PT S AU Tofsted, DH AF Tofsted, David H. BE Thomas, LMW Spillar, EJ TI Three-Dimensional Near-Surface Turbulent Anisotropic Structure Function Measurements SO ATMOSPHERIC PROPAGATION VII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Atmospheric Propagation VII CY APR 06-07, 2010 CL Orlando, FL SP SPIE DE Atmospheric turbulence; atmospheric optics ID LAYER AB A common assumption used in describing the turbulence structure present during atmospheric propagation is turbulent isotropy. Yet low frequency fluctuations obviously cannot exhibit this property since vertically oriented fluctuations are impacted by surface boundary conditions. To gain insight into the anisotropic nature of the surface boundary, a measurement campaign was carried out in the spring of 2008 at White Sands Missile Range, NM. A 2D array of 3D sonic anemometers was constructed. This array, a 14m wide by 10m high grid of sensors was used to sample wind and temperature fluctuations over a two-month period. More than 300 hours of data were collected that fit the criteria of sensor availability, mean winds directed from a desired sector, and steady wind speed. This paper describes the grid, the overall experiment, and considers aspects of correlations present in the temperature data fields that may be useful in characterizing an anisotropic refractive index structure function. C1 USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Tofsted, DH (reprint author), USA, Res Lab, White Sands Missile Range, NM 88002 USA. EM david.tofsted@us.army.mil NR 13 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8149-8 J9 PROC SPIE PY 2010 VL 7685 AR 76850O DI 10.1117/12.850459 PG 12 WC Mechanics; Meteorology & Atmospheric Sciences; Optics SC Mechanics; Meteorology & Atmospheric Sciences; Optics GA BSM44 UT WOS:000284932600019 ER PT S AU Tofsted, DH AF Tofsted, David H. BE Thomas, LMW Spillar, EJ TI A Reanalysis of Short-Exposure Turbulent Effects on Passive Imaging SO ATMOSPHERIC PROPAGATION VII SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Atmospheric Propagation VII CY APR 06-07, 2010 CL Orlando, FL SP SPIE DE Atmospheric optics; turbulence; modulation transfer function AB In 1966, D. L. Fried developed a theoretical framework for describing the modulation transfer function (MTF) of optical turbulence effects for short-exposure imaging, thereby extending Hufnagel and Stanley's model for long-exposure imaging through turbulence. In his analysis Fried assumed the independence of phase perturbations about the mean tilt factor and this tilt factor. In this reanalysis this assumption is deleted, resulting in a new term in the derivation. This term exhibits several new features, including superresolution at high spatial frequencies under moderate turbulence levels, and turbulence strength dependent degradation of the MTF at high turbulence levels. C1 USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP Tofsted, DH (reprint author), USA, Res Lab, White Sands Missile Range, NM 88002 USA. EM david.tofsted@us.army.mil NR 15 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8149-8 J9 P SOC PHOTO-OPT INS PY 2010 VL 7685 AR 768504 DI 10.1117/12.850405 PG 10 WC Mechanics; Meteorology & Atmospheric Sciences; Optics SC Mechanics; Meteorology & Atmospheric Sciences; Optics GA BSM44 UT WOS:000284932600003 ER PT B AU Fritzsche, KH Stewart, CV Roysam, B AF Fritzsche, Kenneth H. Stewart, Charles V. Roysam, Bardrinath BE Jelinek, HF Cree, MJ TI Determining Retinal Vessel Widths and Detection of Width Changes SO AUTOMATED IMAGE DETECTION OF RETINAL PATHOLOGY LA English DT Article; Book Chapter ID 2ND-ORDER GAUSSIAN FILTER; OCULAR FUNDUS IMAGES; BLOOD-VESSEL; CONTOUR REPRESENTATION; COMPUTER; EXTRACTION; DIAMETER; TRACKING; SEGMENTATION; PHOTOGRAPHS C1 [Fritzsche, Kenneth H.] US Mil Acad, Springfield, VA 22150 USA. [Stewart, Charles V.; Roysam, Bardrinath] Rensselaer Polytech Inst, Troy, NY USA. RP Fritzsche, KH (reprint author), US Mil Acad, Springfield, VA 22150 USA. NR 73 TC 1 Z9 1 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-1-4200-3700-5; 978-0-8493-7556-9 PY 2010 BP 269 EP 304 PG 36 WC Engineering, Biomedical; Ophthalmology SC Engineering; Ophthalmology GA BC3DN UT WOS:000351533400010 ER PT S AU Chan, AL AF Chan, Alex Lipchen BE Sadjadi, FA Mahalanobis, A Chodos, SL Thompson, WE Casasent, DP Chao, TH TI A robust target tracking algorithm for FLIR imagery SO AUTOMATIC TARGET RECOGNITION XX; ACQUISITION, TRACKING, POINTING, AND LASER SYSTEMS TECHNOLOGIES XXIV; AND OPTICAL PATTERN RECOGNITION XXI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Automatic Target Recognition XX - Acquisition, Tracking, Pointing, and Laser Systems Technologies XXIV - and Optical Pattern Recognition XXI CY APR 05-08, 2010 CL Orlando, FL SP SPIE DE Target detection; target tracking; moving targets; FLIR imagery; background modeling ID VIDEO; SURVEILLANCE; MOTION AB A robust target tracking algorithm is proposed to overcome a number of challenges often associated with the FLIR imagery. Several disjoint intermediate background models are used to form an accurate and dynamic representation of the current background. The signatures of moving targets are captured and enhanced through a set of image filters, while the next movements of these targets are reasonably estimated using a set of kinematic predictors. By integrating the effective target detection method with the robust background modeling process, an excellent target tracking performance can be achieved. C1 USA, Res Lab, Attent RDRL SES E, Adelphi, MD 20783 USA. RP Chan, AL (reprint author), USA, Res Lab, Attent RDRL SES E, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 25 TC 2 Z9 2 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8160-3 J9 PROC SPIE PY 2010 VL 7696 AR 769603 DI 10.1117/12.850449 PG 11 WC Engineering, Aerospace; Robotics; Optics SC Engineering; Robotics; Optics GA BSH11 UT WOS:000284396300003 ER PT S AU Mehmood, A Nasrabadi, NM AF Mehmood, Asif Nasrabadi, Nasser M. BE Sadjadi, FA Mahalanobis, A Chodos, SL Thompson, WE Casasent, DP Chao, TH TI Anomaly detection in wavelet domain for long-wave FLIR imagery SO AUTOMATIC TARGET RECOGNITION XX; ACQUISITION, TRACKING, POINTING, AND LASER SYSTEMS TECHNOLOGIES XXIV; AND OPTICAL PATTERN RECOGNITION XXI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Automatic Target Recognition XX - Acquisition, Tracking, Pointing, and Laser Systems Technologies XXIV - and Optical Pattern Recognition XXI CY APR 05-08, 2010 CL Orlando, FL SP SPIE DE Anomaly detection; RX; Target detection algorithms; Wavelets; FLIR ID AUTOMATIC TARGET RECOGNITION; HYPERSPECTRAL IMAGERY; ALGORITHMS; TRANSFORM AB This paper describes a new wavelet-based anomaly detection technique for Forward Looking Infrared (FLIR) sensor consisting a Long-wave (LW) and a Mid-wave (MW) sensor. The proposed approach called wavelet-RX algorithm consists of a combination of a two-dimensional (2-D) wavelet transform and the well-known multivariate anomaly detector called the RX algorithm. In our wavelet-RX algorithm, a 2-D wavelet transform is first applied to decompose the input image into uniform subbands. A number of significant subbands (high energy subbands) are concatenated together to form a subband-image cube. The RX algorithm is then applied to each subband-image cube obtained from wavelet decomposition of LW and MW sensor data separately. Experimental results are presented for the proposed wavelet-RX and the classical CFAR algorithm for detecting anomalies (targets) in a single broadband FLIR (LW or MW) sensors. The results show that the proposed wavelet-RX algorithm outperforms the classical CFAR detector for both LW and for MW FLIR sensors data. C1 [Mehmood, Asif; Nasrabadi, Nasser M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Mehmood, A (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM asif.mehmood1@us.army.mil NR 19 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8160-3 J9 PROC SPIE PY 2010 VL 7696 AR 76960S DI 10.1117/12.850211 PG 11 WC Engineering, Aerospace; Robotics; Optics SC Engineering; Robotics; Optics GA BSH11 UT WOS:000284396300025 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI Sketches of Matthew Arnold and John Dewey SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 1 EP 36 PG 36 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200002 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI An Awkward Echo Matthew Arnold and John Dewey Preface SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Editorial Material; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP VIII EP + PG 11 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200001 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI Educational Pluralism SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 37 EP 67 PG 31 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200003 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI The Tentacled Mind SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 69 EP 88 PG 20 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200004 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI The Critical Mind SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 89 EP 147 PG 59 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200005 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI The Intentional Mind SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 149 EP 208 PG 60 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200006 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI The Reflective-Response Mind SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 209 EP 230 PG 22 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200007 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI An Adequate Echo SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 231 EP 253 PG 23 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200008 ER PT B AU Dietz, MD AF Dietz, Mark David BA Dietz, MD BF Dietz, MD TI Postscript: Overhearing Myself SO AWKWARD ECHO: MATTHEW ARNOLD AND JOHN DEWEY SE Research in Curriculum and Instruction LA English DT Article; Book Chapter C1 [Dietz, Mark David] Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. [Dietz, Mark David] Texas Instruments Inc, Semicond Div, Dallas, TX 75265 USA. [Dietz, Mark David] USA, Washington, DC USA. RP Dietz, MD (reprint author), Texas Instruments Inc, Def Div, Dallas, TX 75265 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INFORMATION AGE PUBLISHING-IAP PI CHARLOTTE PA PO BOX 79049, CHARLOTTE, NC 28271-7047 USA BN 978-1-60752-398-7 J9 RES CURRIC INSTRUCT PY 2010 BP 255 EP 260 PG 6 WC Education & Educational Research SC Education & Educational Research GA BNK46 UT WOS:000274799200009 ER PT S AU O'Brien, H Ogunniyi, A Zhang, QJ Agarwal, AK AF O'Brien, Heather Ogunniyi, Aderinto Zhang, Q. Jon Agarwal, Anant K. BE Saddow, SE Sanchez, E Zhao, F Dudley, M TI Pulse Performance and Reliability Analysis of a 1.0 cm(2) 4H-SiC GTO SO B - SILICON CARBIDE 2010-MATERIALS, PROCESSING AND DEVICES SE Materials Research Society Symposium Proceedings LA English DT Proceedings Paper CT MRS Spring Meeting CY APR 05-09, 2010 CL San Francisco, CA SP MRS AB A 1.0 cm(2) silicon carbide Super-GTO was designed and fabricated for Army pulsed power applications. It is a milestone, being the first SiC Super-GTO of this size. The design is the culmination of several years of research into material improvement, termination and gate patterns, optimizing device size, and calibrating pulse performance. The SGTO's forward blocking voltage is 9.0 kV, and its on-state voltage is 2.9 V at turn-on. Six devices were evaluated for pulse capability in a high-energy circuit that was designed to produce a 1-ms wide half-sine shaped pulse. The maximum safe operating current for each of the six Super-GTOs varied from 2.2 kA to 3.4 kA, with 13 V being the typical V-AK at a current of 3.0 kA. Two of the GTOs were also tested for pulse reliability and repeatability. They were individually switched in the pulse circuit for >500 pulses at very low duty cycle. This study is base-level research on pulse capability of the newest generation of SiC Super-GTOs and as such strives to identify the defining characteristics of an optimal device as well as the predominant modes of device failure. C1 [O'Brien, Heather; Ogunniyi, Aderinto] USA, Res Lab, Adelphi, MD 20783 USA. RP O'Brien, H (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 10 TC 0 Z9 0 U1 1 U2 7 PU MATERIALS RESEARCH SOC PI WARRENDALE PA 506 KEYSTONE DRIVE, WARRENDALE, PA 15088-7563 USA SN 0272-9172 BN 978-1-60511-223-7 J9 MATER RES SOC SYMP P PY 2010 VL 1246 DI 10.1557/PROC-1246-B08-03 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA BAW97 UT WOS:000305896100025 ER PT S AU Montgomery, EE AF Montgomery, Edward E. BE Phipps, C komurasaki, K Sinko, J TI Power Beamed Photon Sails: New Capabilities Resulting From Recent Maturation Of Key Solar Sail And High Power Laser Technologies SO BEAMED ENERGY PROPULSION SE AIP Conference Proceedings LA English DT Proceedings Paper CT 6th International Symposium on Beamed Energy Propulsion CY NOV 01-05, 2009 CL Scottsdale, AZ SP Amer Inst Beamed Energy Propuls, US Air Force Off Sci Res, Exquadrum Inc, Photonic Assoc, Lightcraft Tech Int DE beamed energy; laser propulsion; solar sail AB This paper revisits some content in the First International Symposium on Beamed Energy Propulsion in 2002 related to the concept of propellantless in-space propulsion utilizing an external high energy laser to provide momentum to an ultralightweight (gossamer) spacecraft. The design and construction of the NanoSail-D solar sail demonstration spacecraft has demonstrated in space flight hardware the concept of small, very light - yet capable - spacecraft. The results of the Joint High Power Solid State Laser (JHPSSL) have also increased the effectiveness and reduced the cost of an entry level laser source. This paper identifies the impact from improved system parameters on current mission applications. C1 USA, Space & Missile Def Command, Huntsville, AL USA. RP Montgomery, EE (reprint author), USA, Space & Missile Def Command, Huntsville, AL USA. NR 5 TC 1 Z9 1 U1 2 U2 5 PU AMER INST PHYSICS PI MELVILLE PA 2 HUNTINGTON QUADRANGLE, STE 1NO1, MELVILLE, NY 11747-4501 USA SN 0094-243X BN 978-0-7354-0774-9 J9 AIP CONF PROC PY 2010 VL 1230 BP 3 EP 9 DI 10.1063/1.3435457 PG 7 WC Optics; Physics, Applied SC Optics; Physics GA BRR29 UT WOS:000283479800001 ER PT S AU Fleisher, PJ Bailey, PK Natel, EM Muller, EH Cadwell, DH Russell, A AF Fleisher, P. Jay Bailey, Palmer K. Natel, Eric M. Muller, Ernie H. Cadwell, Don H. Russell, Andrew BE Shuchman, RA Josberger, EG TI The 1993-1995 surge and foreland modification, Bering Glacier, Alaska SO BERING GLACIER: INTERDISCIPLINARY STUDIES OF EARTHS LARGEST TEMPERATE SURGING GLACIER SE Geological Society of America Special Papers LA English DT Article; Book Chapter ID DEFORMATION BENEATH GLACIERS; SUBGLACIAL BED CONDITIONS; ICE-SHEET HYDROLOGY; VARIEGATED GLACIER; HOLOCENE HISTORY; PIEDMONT GLACIER; OUTBURST FLOODS; CONDUIT SYSTEM; WATER; MECHANISM AB A 25-30 yr surge cycle anticipated by Post (1972) was confirmed by the 1993-1995 surge, although the advance culminated more than a kilometer short of the 1965-1967 surge limit. During the initial 6 mo. of the 1993-1995 surge the eastern terminus of the Bering Glacier Piedmont Lobe advanced 1.0-1.5 km at a rate that varied between 1.0-7.4 m/d, and thickened by an estimated 125-150 m. One year after the surge began an outburst of pressured subglacial water temporarily interrupted basal sliding and slowed ice front advance. Within days gravel and blocks of ice transported and deposited by that flood partially filled an ice-contact lake, forming a 1.5 km(2) sandur. During the next few months a second outburst nearly dissected a foreland island with the resulting construction of two additional sandar, each nearly 1 km(2). Both outburst sites coincided with a subglacial conduit system that has persisted for decades and survived two surges. When the surge resumed, advance was intermittent and slower. A prominent push moraine marks the limit of ice advance on the eastern sector. Although basal sliding across a saturated substrate was a major contributor to surge-related changes along the eastern sector, the most profound foreland alteration was the result of outburst-related erosion, deposition, and drainage modification associated with outburst floods. The dominant modification of overridden terrain was subglacial hydraulic scouring of sub-kilometer scale basins, 15-20 m deep, and outburst-related proglacial sandur development. Only after a decade of retreat was it possible to assess the limited direct effects of overriding ice, which were confined to deposition of a sub-meter-thick deformation till, decameter-scale flutes, and drumlinized topography accompanied by truncation of subglacial strata. C1 [Fleisher, P. Jay] SUNY Coll Oneonta, Oneonta, NY 13820 USA. [Bailey, Palmer K.] USA, Corps Engineers, Anchor Point, AK 99556 USA. [Natel, Eric M.] Eastman Kodak, Res & Dev, Rochester, NY 14650 USA. [Muller, Ernie H.] Syracuse Univ, Dept Earth Sci, Syracuse, NY 13244 USA. [Cadwell, Don H.] New York State Geol Survey, Albany, NY 12230 USA. [Russell, Andrew] Newcastle Univ, Sch Geog, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England. RP Fleisher, PJ (reprint author), SUNY Coll Oneonta, Oneonta, NY 13820 USA. EM fleishpj@oneonta.edu NR 89 TC 6 Z9 6 U1 1 U2 2 PU GEOLOGICAL SOC AMER INC PI BOULDER PA 3300 PENROSE PL, PO BOX 9140, BOULDER, CO 80301 USA SN 0072-1077 BN 978-0-8137-2462-1 J9 GEOL SOC AM SPEC PAP PY 2010 VL 462 BP 193 EP 216 DI 10.1130/2010.2462(10) PG 24 WC Geology; Geosciences, Multidisciplinary SC Geology GA BTA53 UT WOS:000286213100013 ER PT B AU Crothers, BA Henry, MR Firat, P Hamper, UM AF Crothers, Barbara A. Henry, Michael R. Firat, Pinar Hamper, Ulrike M. BE Ali, SZ Cibas, ES TI Nondiagnostic/Unsatisfactory SO BETHESDA SYSTEM FOR REPORTING THYROID CYTOPATHOLOGY: DEFINITIONS, CRITERIA AND EXPLANATORY NOTES LA English DT Proceedings Paper CT National-Cancer-Institute Conference on Thyroid Fine-Needle Aspiration State of the Science CY OCT 22-23, 2007 CL Bethesda, MD SP Natl Canc Inst ID FINE-NEEDLE-ASPIRATION; SCIENCE CONFERENCE; DIAGNOSTIC TERMINOLOGY; THYROID-NODULES; SYNOPSIS; ADEQUACY; CRITERIA; STATE; FNA C1 [Crothers, Barbara A.] Walter Reed Army Med Ctr, Dept Pathol, Springfield, VA USA. [Henry, Michael R.] Mayo Clin & Mayo Fdn, Dept Lab Med, Dept Pathol, Rochester, MN USA. [Firat, Pinar] Hacettepe Univ, Dept Pathol, Ankara, Turkey. [Hamper, Ulrike M.] Johns Hopkins Med Inst, Dept Radiol & Radiol Sci, 600 N Wolfe St, Baltimore, MD 21205 USA. RP Crothers, BA (reprint author), Walter Reed Army Med Ctr, Dept Pathol, Springfield, VA USA. NR 15 TC 7 Z9 8 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-0-387-87665-8 PY 2010 BP 5 EP + DI 10.1007/978-0-387-87666-5_2 PG 3 WC Endocrinology & Metabolism; Pathology; Radiology, Nuclear Medicine & Medical Imaging; Surgery SC Endocrinology & Metabolism; Pathology; Radiology, Nuclear Medicine & Medical Imaging; Surgery GA BOC73 UT WOS:000276194800002 ER PT J AU Dickson, TL Wilsey, BJ Busby, RR Gebhart, DL AF Dickson, Timothy L. Wilsey, Brian J. Busby, Ryan R. Gebhart, Dick L. TI Melilotus officinalis (yellow sweetclover) causes large changes in community and ecosystem processes in both the presence and absence of a cover crop SO BIOLOGICAL INVASIONS LA English DT Article DE Community restoration; Ecological bridge species; Ecosystem functioning; Exotic legume; Invasive species; Nitrogen isotope ((15)N) ID OLD-FIELD; POSITIVE INTERACTIONS; PHALARIS-ARUNDINACEA; PERENNIAL GRASSES; PLANT-COMMUNITIES; INVASION; GRASSLAND; RESTORATION; COMPETITION; NITROGEN AB Non-native species are hypothesized to decrease native species establishment and cover crops are hypothesized to decrease non-native species abundance. Although many studies have compared invaded to non-invaded habitats, relatively few studies have experimentally added non-native species to directly examine their effects. In a greenhouse mesocosm experiment, we tested the effects of non-native forbs (Melilotus officinalis, Verbascum thapsus, and Lespedeza cuneata), a proposed C(3) grass cover crop (Pascopyrum smithii), and a commonly seeded non-native C(3) grass (Bromus inermis) on the establishment of target native C(4) prairie grass species. All treatments contained the same seed density of target C(4) species and were begun on bare soil collected from the field. The legume M. officinalis strongly decreased the abundance of all other species, species diversity, and light and soil moisture levels. Surprisingly, M. officinalis took up relatively large amounts of labeled nitrogen ((15)N) from the soil early in its development, but M. officinalis fixed nitrogen, thus increasing nitrogen in biomass nearly fivefold by the end of the study. We found few effects of either C(3) grass species on non-native forbs or C(4) target species, but seeded P. smithii did increase species diversity. Non-native plants therefore impeded native C(4) grass establishment through long-lasting effects of target species seedbank depletion (death of most target seedlings) and altered nutrient availability. The effects of M. officinalis were not reduced by the presence of a cover crop. C1 [Dickson, Timothy L.; Wilsey, Brian J.] Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50011 USA. [Busby, Ryan R.; Gebhart, Dick L.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Dickson, TL (reprint author), Iowa State Univ, Dept Ecol Evolut & Organismal Biol, Ames, IA 50011 USA. EM DicksonTL@gmail.com OI Wilsey, Brian J./0000-0002-0628-5006 FU US Army Corps of Engineers Upper Middle Mississippi Valley Cooperative Ecosystem Studies Unit [W9132T-06-2-0007] FX Roxane Fagan at North Carolina State University analyzed all 15N samples. Adam Asche, Andrea Blong, John Smith, Chris Swenson, and Kim Wahl provided greenhouse help. This work was funded by the US Army Corps of Engineers Upper Middle Mississippi Valley Cooperative Ecosystem Studies Unit program Agreement W9132T-06-2-0007. NR 52 TC 3 Z9 3 U1 2 U2 25 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1387-3547 J9 BIOL INVASIONS JI Biol. Invasions PD JAN PY 2010 VL 12 IS 1 BP 65 EP 76 DI 10.1007/s10530-009-9430-7 PG 12 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA 533TJ UT WOS:000272847900006 ER PT J AU Thorp, JH Flotemersch, JE Delong, MD Casper, AF Thoms, MC Ballantyne, F Williams, BS O'Neill, BJ Haase, CS AF Thorp, James H. Flotemersch, Joseph E. Delong, Michael D. Casper, Andrew F. Thoms, Martin C. Ballantyne, Ford Williams, Bradley S. O'Neill, Brian J. Haase, C. Stephen TI Linking Ecosystem Services, Rehabilitation, and River Hydrogeomorphology SO BIOSCIENCE LA English DT Article DE environmental benefits analysis; hydrogeomorphic patches; river management; river rehabilitation; riverine ecosystem synthesis ID CONSERVATION; NETWORKS; ECOLOGY; SYSTEMS; CLASSIFICATION; CONNECTIVITY; BIODIVERSITY; MISSISSIPPI; CONTINUUM; STREAMS AB Assignment of values for natural ecological benefits and anthropocentric ecosystem services in riverine landscapes has been problematic, because a firm scientific basis linking these to the river's physical structure has been absent. Me highlight some inherent problems in this process and suggest possible solutions on the basis of the hydrogeomorphic classification of rivers. We suggest this link can be useful in fair asset trading (mitigation and offsets), selection of sites for rehabilitation, cost-benefit decisions on incremental steps in restoring ecological functions, and general protection of rivers. C1 [Thorp, James H.] Univ Kansas, Dept Ecol & Evolutionary Biol, Lawrence, KS 66045 USA. [Flotemersch, Joseph E.] US EPA, Off Res & Dev, Cincinnati, OH 45268 USA. [Delong, Michael D.] Winona State Univ, Dept Biol, Winona, MN USA. [Casper, Andrew F.] USA, Corps Engineers, Aquat Ecol & Invas Species Branch, Environm Lab,Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Thoms, Martin C.] Univ New England, Div Geog & Planning, Armidale, NSW 2351, Australia. [Thoms, Martin C.] Univ New England, Riverine Landscapes Res Lab, Armidale, NSW 2351, Australia. [Haase, C. Stephen] So US Reg Nat Conservancy, Rockwood, TN USA. RP Thorp, JH (reprint author), Univ Kansas, Dept Ecol & Evolutionary Biol, Lawrence, KS 66045 USA. EM thorp@ku.edu OI Thoms, Martin/0000-0002-8074-0476 FU Office of Research and Development; National Science Foundation [EPS-0553722] FX Support for an ecosystem services workshop came from the EPA's Office of Research and Development, a National Science Foundation EPSCoR grant to the University of Kansas (EPS-0553722; Kristin Bowman-James, primary investigator), and the University of Kansas's Kansas Biological Survey. We thank Greg Toth and two reviewers for comments on an earlier manuscript. NR 37 TC 38 Z9 41 U1 3 U2 57 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0006-3568 EI 1525-3244 J9 BIOSCIENCE JI Bioscience PD JAN PY 2010 VL 60 IS 1 BP 67 EP 74 DI 10.1525/bio.2010.60.1.11 PG 8 WC Biology SC Life Sciences & Biomedicine - Other Topics GA 540CX UT WOS:000273309500010 ER PT S AU Hankus, ME Stratis-Cullum, DN Pellegrino, PM AF Hankus, Mikella E. Stratis-Cullum, Dimitra N. Pellegrino, Paul M. BE Mohseni, H Razeghi, M TI Towards Advanced Biological Detection using Surface Enhanced Raman Scattering (SERS)-based Sensors SO BIOSENSING III SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Biosensing III CY AUG 01-03, 2010 CL San Diego, CA SP SPIE DE SERS; Raman; sensor; biologicals; surface enhanced Raman scattering; molecular probe; fluorescence ID GOLD NANOPARTICLES; SERS SPECTROSCOPY; BACTERIAL-SPORES; CHEMICAL-AGENTS; NANOSTRUCTURES; SILVER; DISCRIMINATION; IDENTIFICATION; MOLECULES; APTAMERS AB The Army has a need for an accurate, fast, reliable and robust means to identify and quantify defense related materials. Raman spectroscopy is a form of vibrational spectroscopy that is rapidly becoming a valuable tool for homeland defense applications, as it is well suited for the molecular identification of a variety of compounds, including explosives and chemical and biological hazards. To measure trace levels of these types of materials, surface enhanced Raman scattering (SERS), a specialized form of Raman scattering, can be employed. The SERS enhancements are produced on, or in close proximity to, a nanoscale roughened metal surface and are typically associated with increased local electromagnetic field strengths. However, before application of SERS in the field and in particular to biological and other hazard sensing applications, significant improvements in substrate performance are needed. In this work, we will report the use of several SERS substrate architectures (colloids, film-over-nanospheres (FONs) and commercially available substrates) for detecting and differentiating numerous endospore samples. The variance in spectra as obtained using different sensing architectures will also be discussed. Additionally, the feasibility of using a modified substrate architecture that is tailored with molecular recognition probe system for detecting biological samples will be explored. We will discuss the progress towards an advanced, hybrid molecular recognition with a SERS/Fluorescence nanoprobe system including the optimization, fabrication, and spectroscopic analysis of samples on a commercially available substrate. Additionally, the feasibility of using this single-step switching architecture for hazard material detection will also be explored. C1 [Hankus, Mikella E.; Stratis-Cullum, Dimitra N.; Pellegrino, Paul M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Hankus, ME (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Hankus, Mikella/A-9005-2012 NR 59 TC 2 Z9 2 U1 0 U2 11 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8255-6 J9 PROC SPIE PY 2010 VL 7759 AR 77590G DI 10.1117/12.859267 PG 13 WC Engineering, Biomedical; Remote Sensing; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Engineering; Remote Sensing; Optics; Radiology, Nuclear Medicine & Medical Imaging GA BSU76 UT WOS:000285834600005 ER PT J AU Mandels, M Hontz, L Nystrom, J AF Mandels, Mary Hontz, Lloyd Nystrom, John TI Enzymatic Hydrolysis of Waste Cellulose SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article ID TRICHODERMA-VIRIDE; SACCHARIFICATION; GLUCOSE; WOOD AB Waste cellulose was a suitable carbon source for cellulase production by Trichoderma viride. The enzyme can be produced in submerged fermentation using newspaper as a growth substrate. A variety of pure and complex cellulosic materials were hydrolyzed by culture filtrates. Saccharification of 5% slurries after 48 hr ranged from 2-92%. The rate and extent of hydrolysis was controlled by degree of crystallinity, particle size, and presence of impurities. Newspaper was used to evaluate methods for the pretreatment of substrate. The best pretreatment was ball milling which gave good size reduction, maximum bulk density, and maximum susceptibility. Hammer milling, fluid energy milling, colloid milling, or alkali treatments were less satisfactory. Dissolving cellulose in cuprammonium, or carbon disulfide (Viscose) and then reprecipitating gave a susceptible, but low bulk density product. However the susceptibility was lost if the substrate was dried. Because of costs, low bulk density, necessity of keeping the substrate wet, and generation of chemical waste streams dissolving cellulose to increase reactivity does not seem a practical approach. Cellulose fractions separated from municipal trash or agricultural residues such as milled fibers from bovine manure are promising substrates for conversion. C1 [Mandels, Mary; Hontz, Lloyd; Nystrom, John] USA, Natick Labs, Natick, MA 01760 USA. RP Mandels, M (reprint author), USA, Natick Labs, Natick, MA 01760 USA. NR 31 TC 4 Z9 4 U1 3 U2 10 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0006-3592 J9 BIOTECHNOL BIOENG JI Biotechnol. Bioeng. PD JAN 1 PY 2010 VL 105 IS 1 BP 3 EP 25 PG 23 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 531HV UT WOS:000272656200002 PM 19937801 ER PT J AU Simmons, JW Chung, KK Renz, EM White, CE Cotant, CL Tilley, MA Hardin, MO Jones, JA Blackbourne, LH Wolf, SE AF Simmons, John W. Chung, Kevin K. Renz, Evan M. White, Christopher E. Cotant, Casey L. Tilley, Molly A. Hardin, Mark O. Jones, John A. Blackbourne, Lorne H. Wolf, Steven E. TI Fenoldopam use in a burn intensive care unit: a retrospective study SO BMC ANESTHESIOLOGY LA English DT Article AB Background: Fenoldopam mesylate is a highly selective dopamine-1 receptor agonist approved for the treatment of hypertensive emergencies that may have a role at low doses in preserving renal function in those at high risk for or with acute kidney injury (AKI). There is no data on low-dose fenoldopam in the burn population. The purpose of our study was to describe our use of low-dose fenoldopam (0.03-0.09 mu g/kg/min) infusion in critically ill burn patients with AKI. Methods: We performed a retrospective analysis of consecutive patients admitted to our burn intensive care unit (BICU) with severe burns from November 2005 through September 2008 who received low-dose fenoldopam. Data obtained included systolic blood pressure, serum creatinine, vasoactive medication use, urine output, and intravenous fluid. Patients on concomitant continuous renal replacement therapy were excluded. Modified inotrope score and vasopressor dependency index were calculated. One-way analysis of variance with repeated measures, Wilcoxson signed rank, and chi-square tests were used. Differences were deemed significant at p < 0.05. Results: Seventy-seven patients were treated with low-dose fenoldopam out of 758 BICU admissions (10%). Twenty (26%) were AKI network (AKIN) stage 1, 14 (18%) were AKIN stage 2, 42 (55%) were AKIN stage 3, and 1 (1%) was AKIN stage 0. Serum creatinine improved over the first 24 hours and continued to improve through 48 hours (p < 0.05). There was an increase in systolic blood pressure in the first 24 hours that was sustained through 48 hours after initiation of fenoldopam (p < 0.05). Urine output increased after initiation of fenoldopam without an increase in intravenous fluid requirement (p < 0.05; p = NS). Modified inotrope score and vasopressor dependency index both decreased over 48 hours (p < 0.0001; p = 0.0012). Conclusions: These findings suggest that renal function was preserved and that urine output improved without a decrease in systolic blood pressure, increase in vasoactive medication use, or an increase in resuscitation requirement in patients treated with low-dose fenoldopam. A randomized controlled trial is required to establish the efficacy of low-dose fenoldopam in critically ill burn patients with AKI. C1 [Simmons, John W.; Chung, Kevin K.; Renz, Evan M.; White, Christopher E.; Hardin, Mark O.; Jones, John A.; Blackbourne, Lorne H.; Wolf, Steven E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Cotant, Casey L.; Tilley, Molly A.] Wilford Hall USAF Med Ctr, San Antonio, TX 78236 USA. [Renz, Evan M.; White, Christopher E.; Wolf, Steven E.] UT Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Chung, Kevin K.; Renz, Evan M.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Simmons, JW (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM john.simmons@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 55 TC 3 Z9 3 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2253 J9 BMC ANESTHESIOL JI BMC Anesthesiol. PY 2010 VL 10 AR 9 DI 10.1186/1471-2253-10-9 PG 7 WC Anesthesiology SC Anesthesiology GA V27TW UT WOS:000208636500009 PM 20576149 ER PT J AU Larson, GJ Lawson, DE Evenson, EB Knudsen, O Alley, RB Phanikumar, MS AF Larson, Grahame J. Lawson, Daniel E. Evenson, Edward B. Knudsen, Oskar Alley, Richard B. Phanikumar, Mantha S. TI Origin of stratified basal ice in outlet glaciers of Vatnajokull and Oraefajokull, Iceland SO BOREAS LA English DT Article ID FREEZE-ON MECHANISM; MATANUSKA GLACIER; SOUTHEAST ICELAND; ISOTOPE FRACTIONATION; OXYGEN-ISOTOPE; FRAZIL ICE; DEBRIS; WATER; REGELATION; ALASKA AB During the period 2000-2005, we collected samples of englacial ice, vent water, frazil/anchor ice and stratified basal ice from warm-based outlet glaciers of Vatnajokull and Oraefajokull, Iceland, and analysed them for 3H, 18O and D. Results of 3H analyses show that the stratified basal ice contains 3H from atmospheric thermonuclear testing and is younger than the englacial ice. Results of the 18O and D analyses show that frazil/anchor and stratified basal ice are both enriched by an average of 2.4 parts per thousand in 18O and 11 parts per thousand in D relative to vent water. These values are consistent with fractionation during partial freezing of supercooled subglacial water in an open system, one in which the remaining water is continuously removed and replenished by water of similar composition. The isotopic data and field observations do not support either a regelation or a thermal ad-freeze-on origin for the stratified basal ice. C1 [Larson, Grahame J.] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. [Lawson, Daniel E.] Cold Reg Res & Engn Lab, Terrain & Cryospher Sci Branch, Hanover, NH 03755 USA. [Evenson, Edward B.] Lehigh Univ, Dept Earth & Environm Sci, Bethlehem, PA 18015 USA. [Alley, Richard B.] Penn State Univ, Dept Geosci, University Pk, PA 16802 USA. [Alley, Richard B.] Penn State Univ, Earth & Environm Syst Inst, University Pk, PA 16802 USA. [Phanikumar, Mantha S.] Michigan State Univ, Dept Civil & Environm Engn, E Lansing, MI 48824 USA. RP Larson, GJ (reprint author), Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA. EM larsong@msu.edu; Daniel.E.Lawson@usace.army.mil; ede0@Lehigh.edu; oskar@versco.is; ralley@geosc.psu.edu; phani@msu.edu FU National Science Foundation Office; US Army Cold Regions Research and Engineering Laboratory (CRREL) FX We thank the National Science Foundation Office for funding of our research on glaciohydraulic supercooling. We also wish to acknowledge the US Army Cold Regions Research and Engineering Laboratory (CRREL) for support, including funding for the isotopic analyses. Special thanks go to Teryn Ebert, Sarah Kopczynski and Michiel Kramer for their assistance in the field, and to Helgi Bjornsson and Finnur Palsson for informative discussions about Icelandic glacial systems and their radar profiling data of the outlet glaciers. We are particularly grateful to Ragnar Frank Kristjansson of the Skaftafell National Park for housing and logistical support, and for lively discussions of Icelandic historical observations of glacial activity. We thank Peggy Ostrom and the Center for Statistical Training and Consulting at Michigan State University for their help with statistical analyses. Finally, we thank Neal Iverson and an anonymous reviewer for their constructive reviews of this article, Simon J. Cook for his helpful comments on an earlier version of the article, and Jan A. Piotrowski for editorial comments. NR 67 TC 2 Z9 2 U1 3 U2 11 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0300-9483 J9 BOREAS JI Boreas PY 2010 VL 39 IS 3 BP 457 EP 470 DI 10.1111/j.1502-3885.2009.00134.x PG 14 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 612QN UT WOS:000278916600001 ER PT J AU Ray, JC AF Ray, James C. BE Frangopol, DM Sause, R Kusko, CS TI The evolving science of terrorist threat mitigation for bridges SO BRIDGE MAINTENANCE, SAFETY, MANAGEMENT AND LIFE-CYCLE OPTIMIZATION LA English DT Proceedings Paper CT 5th International Conference on Bridge Maintenance, Safety and Management (IABMAS) CY JUL 11-15, 2010 CL Lehigh Univ, Adv Technol Large Struct Syst (ATLSS) Engn Res Ctr, Philadelphia, PA SP Digitexx Data Syst, Inc, U S Dept Transportat, Fed Highway Adm, Penn Infrastructure Technol Alliance (PITA), T Y Lin Int, Int Assoc Bridge Maintenance & Safety (IABMAS) HO Lehigh Univ, Adv Technol Large Struct Syst (ATLSS) Engn Res Ctr AB Since September 11, 2001 (9-11), a new threat has been added to the list of all others that endanger our nation's bridges: Terrorists! This paper discusses the various ways in which a terrorist may attack a bridge and provides an overview of the current state-of-the-art for mitigation of these threats and how it has evolved from almost nothing since 9-11. The science is still very much in its infancy and has far to go before it reaches the level of maturity and definition desired by engineers endeavoring to address the threat in their bridge designs and retrofits. While it is very sad that this science even has to exist, it is exciting for engineers and scientists hoping to make a difference in the world that there is a unique new arena in which there is still so much room for innovation and development. The author discusses the science in terms of three major categories: mitigation prioritization; vulnerability assessments; and threat mitigation. The purpose of the paper is to present the science within a concise framework and provide a glimpse of what has been done in each category since its beginning in order to better educate and inspire engineers and scientists that are just beginning in this important area. C1 US Army, Engineer Res & Dev Ctr ERDC, Adelphi, MD 20783 USA. RP Ray, JC (reprint author), US Army, Engineer Res & Dev Ctr ERDC, Adelphi, MD 20783 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-415-87786-2 PY 2010 BP 78 EP 92 PG 15 WC Engineering, Civil; Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA BFN40 UT WOS:000320615000007 ER PT J AU Ray, J Chiarito, V Walker, B Minor, J AF Ray, J. Chiarito, V. Walker, B. Minor, J. BE Frangopol, DM Sause, R Kusko, CS TI Mitigation of terrorist threats to structural components SO BRIDGE MAINTENANCE, SAFETY, MANAGEMENT AND LIFE-CYCLE OPTIMIZATION LA English DT Proceedings Paper CT 5th International Conference on Bridge Maintenance, Safety and Management (IABMAS) CY JUL 11-15, 2010 CL Lehigh Univ, Adv Technol Large Struct Syst (ATLSS) Engn Res Ctr, Philadelphia, PA SP Digitexx Data Syst, Inc, U S Dept Transportat, Fed Highway Adm, Penn Infrastructure Technol Alliance (PITA), T Y Lin Int, Int Assoc Bridge Maintenance & Safety (IABMAS) HO Lehigh Univ, Adv Technol Large Struct Syst (ATLSS) Engn Res Ctr AB Many significant structures, including buildings, bridges, tunnels, etc. are threatened by terrorist attack. While very different in terms of their function, all of these structures are ultimately composed of basic structural components: plates, beams, columns, cables, etc. This presentation will provide a basic overview of explosive blast mitigation techniques for basic structural components that are applicable to any structure type. Mitigation techniques are categorized and discussed in terms of the manner in which they affect the most basic law of motion, Newton's second law. Results from recent high explosive tests conducted by the authors are presented and used to show the effectiveness of the varied concepts. C1 [Ray, J.; Chiarito, V.; Walker, B.; Minor, J.] USA, Erdc, Washington, DC 20310 USA. RP Ray, J (reprint author), USA, Erdc, Washington, DC 20310 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-415-87786-2 PY 2010 BP 2640 EP 2647 PG 8 WC Engineering, Civil; Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA BFN40 UT WOS:000320615004057 ER PT J AU Greer, L Patel, B Kreishman, P Via, K Fox, C AF Greer, L. Patel, B. Kreishman, P. Via, K. Fox, C. TI Management of secondary haemorrhage from early graft failure in military extremity wounds SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT Electronic Poster of Distinction in Association-of-Surgeons-of-Great-Britain-and-Ireland-International-Surgi cal-Congress CY APR 14-16, 2010 CL Liverpool, ENGLAND SP Assoc Surg Great Britain & Ireland Int Surg Congress C1 [Greer, L.; Patel, B.; Kreishman, P.; Via, K.; Fox, C.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0007-1323 J9 BRIT J SURG JI Br. J. Surg. PY 2010 VL 97 SU 2 BP 23 EP 23 PG 1 WC Surgery SC Surgery GA 764WA UT WOS:000290664000065 ER PT J AU Fox, C Perkins, J Kragh, J Singh, N Patel, B AF Fox, C. Perkins, J. Kragh, J. Singh, N. Patel, B. TI Popliteal artery repair in massively transfused military casualties: a pursuit to save life and limb SO BRITISH JOURNAL OF SURGERY LA English DT Meeting Abstract CT Electronic Poster of Distinction in Association-of-Surgeons-of-Great-Britain-and-Ireland-International-Surgi cal-Congress CY APR 14-16, 2010 CL Liverpool, ENGLAND SP Assoc Surg Great Britain & Ireland Int Surg Congress C1 [Fox, C.; Perkins, J.; Kragh, J.; Singh, N.; Patel, B.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0007-1323 J9 BRIT J SURG JI Br. J. Surg. PY 2010 VL 97 SU 2 BP 197 EP 197 PG 1 WC Surgery SC Surgery GA 764WA UT WOS:000290664000617 ER PT J AU Luria, T Matsliah, Y Adir, Y Josephy, N Moran, DS Evans, RK Abramovich, A Eliakim, A Nemet, D AF Luria, Tal Matsliah, Yinnon Adir, Yochai Josephy, Noam Moran, Daniel S. Evans, Rachel K. Abramovich, Amir Eliakim, Alon Nemet, Dan TI Effects of a Prolonged Submersion on Bone Strength and Metabolism in Young Healthy Submariners SO CALCIFIED TISSUE INTERNATIONAL LA English DT Article DE Bone density technology; Ultrasound; Osteoporosis; Exercise; Physical factors; Mechanical loading ID QUANTITATIVE ULTRASOUND; CALCIUM-METABOLISM; SUPPLEMENTATION; OSTEOPOROSIS; COMPARTMENT; FRACTURE; DISEASE; MARKERS; TIBIA; RISK AB Submariners taking part in prolonged missions are exposed to environmental factors that may adversely affect bone health. Among these, relatively high levels of CO(2), lack of sunlight exposure affecting vitamin D metabolism, limited physical activity, and altered dietary habits. The aims of this study were to examine the effect of a prolonged submersion (30 days) on changes in bone strength using quantitative bone speed of sound and in markers of bone metabolism that include bone turnover (BAP, PINP, TRAP5b, and CTx) and endocrine regulators (serum calcium, PTH, and 25[OH]D) in a group of 32 young healthy male submariners. The prolonged submersion led to increases in body weight and BMI and to a decrease in fitness level. There was a significant decrease in bone strength following the submersion. Speed of sound exhibited continued decline at 4 weeks after return to shore and returned to baseline levels at the 6-month follow-up. There was a significant increase in circulating calcium level. PTH and 25(OH)D levels decreased significantly. Significant decreases were observed in both TRAP5b and CTx levels, markers of bone resorption, as well as in N-terminal propeptide of type I collagen (PINP), a bone formation marker. Prolonged submersion led to a significant decrease in bone strength, accompanied by an overall decrease in bone metabolism. Bone strength was regained only 6 months after return to shore. Prevention and/or rehabilitation programs should be developed following periods of relative disuse even for young submariners. The effects of repeated prolonged submersions on bone health are yet to be determined. C1 [Nemet, Dan] Meir Hosp, Dept Pediat, IL-44281 Kefar Sava, Israel. [Luria, Tal; Matsliah, Yinnon; Adir, Yochai; Josephy, Noam; Abramovich, Amir] IDF Med Corps, Israel Naval Med Inst, Haifa, Israel. [Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Eliakim, Alon; Nemet, Dan] Tel Aviv Univ, Sackler Sch Med, Meir Gen Hosp, Child Hlth & Sports Ctr, IL-69978 Tel Aviv, Israel. RP Nemet, D (reprint author), Meir Hosp, Dept Pediat, 59 Tchernichovski St, IL-44281 Kefar Sava, Israel. EM sivanida@gmail.com; dan.nemet@clalit.org.il NR 31 TC 14 Z9 16 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0171-967X J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PD JAN PY 2010 VL 86 IS 1 BP 8 EP 13 DI 10.1007/s00223-009-9308-9 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 537HA UT WOS:000273102700002 PM 19882096 ER PT J AU Gallo, A AF Gallo, Andrew TI Combating terrorism: Saudi Arabia's role in the war on terror SO CAMBRIDGE REVIEW OF INTERNATIONAL AFFAIRS LA English DT Book Review C1 [Gallo, Andrew] US Mil Acad, West Point, NY 10996 USA. RP Gallo, A (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND SN 0955-7571 J9 CAMB REV INT AFF JI Camb. Rev. Int. Aff. PY 2010 VL 23 IS 4 BP 623 EP 624 PG 2 WC International Relations; Political Science SC International Relations; Government & Law GA 734ZA UT WOS:000288381400005 ER PT J AU Whitman, EJ Pomerantz, M Chen, YM Chamberlin, MM Furusato, B Gao, C Ali, A Ravindranath, L Dobi, A Sestrehenn, IA McLeod, DG Srivastava, S Freedman, M Petrovics, G AF Whitman, Eric J. Pomerantz, Mark Chen, Yongmei Chamberlin, Michael M. Furusato, Bungo Gao, Chunling Ali, Amina Ravindranath, Lakshmi Dobi, Albert Sestrehenn, Isabell A. McLeod, David G. Srivastava, Shiv Freedman, Matthew Petrovics, Gyorgy TI Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION LA English DT Article ID 5 GENETIC-VARIANTS; GENOME-WIDE ASSOCIATION; CHROMOSOME 8Q24; LOCUS; CONFIRMATION; POPULATIONS; AMERICANS; MORTALITY; MULTIPLE; MEN AB Purpose: A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles show a strong association in African-American men. This study was designed to evaluate associations between 8q24 risk alleles and clinical variables, such as pathologic stage, age at diagnosis, and recurrence, in a case series of African-American men. Experimental Design: Peripheral blood DNA samples from 114 African-American men with prostate cancer, including 106 who had undergone radical prostatectomy, were genotyped for six single-nucleotide polymorphisms on three 8q24 regions. The presence of these single-nucleotide polymorphisms was compared with clinicopathologic and follow-up data after radical prostatectomy. Results: The mean age of diagnosis and follow-up time were 57.4 (+/-8.9) years and 49.1 (+/-31.6) months, respectively. Patients carrying the Broad11934905 A risk allele, which is specific for African ancestry, were more likely to have a higher pathologic stage (pT(3-4)) than individuals with the wild type (odds ratio, 4.48; 95%, confidence interval, 1.42-14.14; P = 0.011). A trend toward increased frequency of and shorter time to biochemical recurrence was noted in patients with this risk allele on Kaplan-Meier unadjusted survival analysis (P = 0.076). Conclusions: The Broad11934905 polymorphism at 8q24, which is only found in people of African ancestry, is associated with an increase in non-organ-con fined prostate cancer at prostatectomy. In addition, for those with this risk allele, there is a trend toward early biochemical recurrence that requires validation in larger studies. Cancer Epidemiol Biomarkers Prev; 19(1); 1-8. @2010 AACR. C1 [Whitman, Eric J.; Chamberlin, Michael M.; Ali, Amina; McLeod, David G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC USA. [Furusato, Bungo; Sestrehenn, Isabell A.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Chen, Yongmei; Furusato, Bungo; Gao, Chunling; Ravindranath, Lakshmi; Dobi, Albert; McLeod, David G.; Srivastava, Shiv; Petrovics, Gyorgy] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD USA. [Pomerantz, Mark; Freedman, Matthew] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA. [Dobi, Albert; McLeod, David G.; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Bethesda, MD USA. RP Freedman, M (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA 02115 USA. EM freedman@broad.mit.edu; gpetrovics@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 NR 26 TC 21 Z9 22 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 1055-9965 J9 CANCER EPIDEM BIOMAR JI Cancer Epidemiol. Biomarkers Prev. PD JAN PY 2010 VL 19 IS 1 BP 1 EP 8 DI 10.1158/1055-9965.EPI-08-1111 PG 8 WC Oncology; Public, Environmental & Occupational Health SC Oncology; Public, Environmental & Occupational Health GA 543OA UT WOS:000273586700001 PM 20056617 ER PT J AU Peterson, GW Rossin, JA Smith, PB Wagner, GW AF Peterson, Gregory W. Rossin, Joseph A. Smith, Philip B. Wagner, George W. TI Effects of water on the removal of methyl bromide using triethylene diamine impregnated carbon SO CARBON LA English DT Article ID ACTIVATED CARBON; ADSORPTION; IODIDE AB The removal of methyl bromide (CH(3)Br) from streams of dry and humid air was investigated using coconut shell carbon impregnated with triethylene diamine (TEDA). The relative humidity of the air stream had a significant effect on the CH(3)Br breakthrough time, but not the removal capacity, especially as the relative humidity of the air stream was increased to greater than 50%. The decrease in the breakthrough time was attributed to an increased in the amount of water physically adsorbed by the carbon substrate, leading to a significant decrease in the CH(3)Br adsorption capacity. NMR results revealed TEDA was reacting directly with CH(3)Br, leading to the formation of primarily a mono-substituted quaternary amine, with only small amounts of the di-substituted quaternary amine detected. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Rossin, Joseph A.] Guild Associates Inc, Dublin, OH 43016 USA. [Peterson, Gregory W.; Wagner, George W.] USA, ECBC, Aberdeen Proving Ground, MD 21010 USA. [Smith, Philip B.] SAIC Inc, Gunpowder Branch, Aberdeen Proving Ground, MD 21010 USA. RP Rossin, JA (reprint author), Guild Associates Inc, 5750 Shier Rings Rd, Dublin, OH 43016 USA. EM jarossin@guildassociates.com NR 17 TC 11 Z9 11 U1 2 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0008-6223 J9 CARBON JI Carbon PD JAN PY 2010 VL 48 IS 1 BP 81 EP 88 DI 10.1016/j.carbon.2009.08.038 PG 8 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 522SK UT WOS:000272018800011 ER PT S AU Doona, CJ Kustin, K Feeherry, FE AF Doona, C. J. Kustin, K. Feeherry, F. E. BE Doona, CJ Kustin, K Feeherry, FE TI Case studies in novel food processing technologies Innovations in processing, packaging and predictive modelling Preface SO CASE STUDIES IN NOVEL FOOD PROCESSING TECHNOLOGIES: INNOVATIONS IN PROCESSING, PACKAGING, AND PREDICTIVE MODELLING SE Woodhead Publishing in Food Science Technology and Nutrition LA English DT Editorial Material; Book Chapter C1 [Doona, C. J.; Feeherry, F. E.] USA, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. [Kustin, K.] Brandeis Univ, Dept Chem MS015, Waltham, MA 02453 USA. RP Doona, CJ (reprint author), USA, Natick Soldier RD&E Ctr, 15 Kansas St, Natick, MA 01760 USA. EM christopher.doona@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2042-8049 BN 978-1-84569-551-4 J9 WOODHEAD PUBL FOOD S JI Woodhead Publ. Food Sci. Technol. Nutr. PY 2010 IS 197 BP XXVII EP XXX D2 10.1533/9780857090713 PG 4 WC Food Science & Technology SC Food Science & Technology GA BVB49 UT WOS:000290957900001 ER PT S AU Thellen, C Ratto, JA Froio, D Lucciarini, J AF Thellen, C. Ratto, J. A. Froio, D. Lucciarini, J. BE Doona, CJ Kustin, K Feeherry, FE TI Development of a nanocomposite meal bag for individual military rations SO CASE STUDIES IN NOVEL FOOD PROCESSING TECHNOLOGIES: INNOVATIONS IN PROCESSING, PACKAGING, AND PREDICTIVE MODELLING SE Woodhead Publishing in Food Science Technology and Nutrition LA English DT Article; Book Chapter DE nanocomposites; packaging; rations; Meal Ready-To-Eat (TM) AB It has been known for some time that quality food and rations are important for providing health, morale, and discipline to the men and women of the armed forces. Military rations and supplies have undergone quite a few progressive changes throughout the years, as new technologies have paved the way for next generations of military feeding systems. The latest significant effect on the development and progression of future ration systems is nanotechnology. By utilizing the advanced mechanical, thermal, and barrier properties of nanocomposite systems, the next generation of packaging materials for MREs (TM) (Meal Ready-to-Eat (TM)) are being developed, to be lighter weight, recyclable, and to outperform the current MRE (TM) individual ration packaging systems. This chapter summarizes the progression of modern military rations and introduces research and development of new ration packaging systems based on the use of nanotechnology. C1 [Thellen, C.; Ratto, J. A.; Froio, D.; Lucciarini, J.] USA, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. RP Thellen, C (reprint author), USA, Natick Soldier RD&E Ctr, 15 Kansas St, Natick, MA 01760 USA. EM Christopher.Thellen@us.army.mil RI Dopko, Rae/J-7437-2015 NR 17 TC 0 Z9 0 U1 2 U2 6 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2042-8049 BN 978-1-84569-551-4 J9 WOODHEAD PUBL FOOD S JI Woodhead Publ. Food Sci. Technol. Nutr. PY 2010 IS 197 BP 367 EP 386 DI 10.1533/9780857090713.3.367 D2 10.1533/9780857090713 PG 20 WC Food Science & Technology SC Food Science & Technology GA BVB49 UT WOS:000290957900016 ER PT S AU Doona, CJ Feeherry, FE Ross, EW AF Doona, C. J. Feeherry, F. E. Ross, E. W. BE Doona, CJ Kustin, K Feeherry, FE TI A case study in military ration foods: the Quasi-chemical model and a novel accelerated three-year challenge test SO CASE STUDIES IN NOVEL FOOD PROCESSING TECHNOLOGIES: INNOVATIONS IN PROCESSING, PACKAGING, AND PREDICTIVE MODELLING SE Woodhead Publishing in Food Science Technology and Nutrition LA English DT Article; Book Chapter DE Quasi-chemical model; S. aureus growth/death kinetics; Maple-filled French toast intermediate moisture enrobed sandwich; accelerated 3-year microbial challenge test ID STAPHYLOCOCCUS-AUREUS; WATER ACTIVITY; GROWTH; KINETICS; DEATH; BREAD AB Maple-filled French toast (MFFT) enrobed sandwiches are intermediate moisture (IM) bi-layered foods formulated with 'hurdles' to prevent the growth of Staphylococcus aureus for product shelf-life (3 years at T = 80 degrees F approximate to 27 degrees C). A novel approach to accelerate microbial challenge testing was investigated. The Quasi-chemical model's secondary model ('growth-no-growth boundary') was used to guide the formulation of the MITT. The novel 3-year test protocol used a five-strain cocktail of S. aureus to challenge MITT with variations in storage temperature, product formulation, and packaging atmosphere. The inactivation kinetics were evaluated with the modified Quasi-chemical model and determined to be more rapid at T = 35 degrees C than at T = 25 degrees C. Removing the oxygen scavenger did not promote S. aureus growth. These results provide a basis for standardizing accelerated microbial challenge tests for new varieties of IM enrobed sandwiches in the pipeline to save time, money, and labor, while ensuring food safety. C1 [Doona, C. J.; Feeherry, F. E.; Ross, E. W.] USA, Natick Soldier RD&E Ctr, Natick, MA 01760 USA. RP Doona, CJ (reprint author), USA, Natick Soldier RD&E Ctr, 15 Kansas St, Natick, MA 01760 USA. EM christopher.doona@us.army.mil; florence.edna.feeherry@us.army.mil NR 29 TC 2 Z9 2 U1 0 U2 1 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2042-8049 BN 978-1-84569-551-4 J9 WOODHEAD PUBL FOOD S JI Woodhead Publ. Food Sci. Technol. Nutr. PY 2010 IS 197 BP 489 EP 513 DI 10.1533/9780857090713.4.489 D2 10.1533/9780857090713 PG 25 WC Food Science & Technology SC Food Science & Technology GA BVB49 UT WOS:000290957900022 ER PT B AU Friedlander, AM AF Friedlander, Arthur M. BE Shafferman, A Ordentlich, A Velan, B TI The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics SO CHALLENGE OF HIGHLY PATHOGENIC MICROORGANISMS: MECHANISMS OF VIRULENCE AND NOVEL MEDICAL COUNTERMEASURES LA English DT Proceedings Paper CT 46th Oholo Conference on the Challenge of Highly Pathogenic Microorganisms - Mechanisms of Virulence and Novel Medical Countermeasures CY OCT 25-29, 2009 CL Eilat, ISRAEL SP Israel Inst Biol Res DE Anthrax; Capsule; Vaccine; Therapy; Capsule depolymerase ID BACILLUS-ANTHRACIS; VIRULENCE; DEPOLYMERASE; MACROPHAGES; INFECTION AB The polyglutamic acid capsule of Bacillus anthracis is a well-established virulence factor, conferring antiphagocytic properties on the bacillus. We have shown that the capsule also confers partial resistance to killing by human defensins. In our research we targeted the anthrax capsule for developing medical countermeasures, first using the capsule as a vaccine, similar to successful efforts with other bacteria, and secondly, by developing a novel therapeutic against the capsule. Our experiments showed that a capsule vaccine is protective in the mouse model and its efficacy could be enhanced by conjugation to a protein carrier. In initial experiments using high challenge doses, a capsule conjugate vaccine was not protective in rabbits but did show some protection in nonhuman primates. This suggests it may be useful as an addition to a protective antigen-based vaccine. We are also developing the use of the B. anthracis capsule-depolymerizing enzyme, CapD, as a therapeutic. We demonstrated that in vitro treatment of the encapsulated anthrax bacillus with CapD enzymatically removed the capsule from the bacterial surface making it susceptible to phagocytic killing. Initial experiments in vivo showed that CapD could be used successfully to treat experimental anthrax infections. Such a novel approach to target the capsule virulence factor might be of value in the treatment of infections due to antibiotic-resistant strains. C1 US Army Med Res Inst Infect Dis, Frederick, MD 21702 USA. RP Friedlander, AM (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA. EM arthur.friedlander@amedd.army.mil NR 22 TC 2 Z9 2 U1 1 U2 4 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS BN 978-90-481-9053-9 PY 2010 BP 1 EP 9 DI 10.1007/978-90-481-9054-6_1 PG 9 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA BGG65 UT WOS:000322847000001 ER PT S AU Christesen, S AF Christesen, Steven BE Fountain III, AW Gardner, PJ TI Improved Raman sensitivity using polarization analysis SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI CY APR 06-08, 2010 CL Orlando, FL SP SPIE DE Raman; polarization; depolarization ratio; surface detection AB Raman spectroscopy is a very powerful technique for molecular identification, and small Raman instruments have been used successfully to identify toxic substances. The sensitivity of the technique, however, can be limited by fluorescence interference arising from the analyte itself or sample impurities. In the case of surface detection, the Raman signature and/or fluorescence from the surface can also interfere with identification of the target chemical. We take advantage of the polarization characteristics of the Raman scattering to reduce the broadband fluorescence background and surface Raman features. Using a custom fiber optic probe with excitation at 785 nm, we have demonstrated real-time polarization analysis. The spectrum obtained by ratioing the parallel and perpendicular polarization components of the Raman scattering, reduces the surface signature and has a better spectral correlation to the target analyte. C1 USA, Edgewood Chem Biol Ctr, APG EA, Aberdeen Proving Ground, MD 21010 USA. RP Christesen, S (reprint author), USA, Edgewood Chem Biol Ctr, APG EA, Aberdeen Proving Ground, MD 21010 USA. NR 3 TC 0 Z9 0 U1 1 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8129-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7665 AR 76651B DI 10.1117/12.851007 PG 7 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSS35 UT WOS:000285626600040 ER PT S AU Ginsberg, MD Smith, ED VanBlaricum, V Hock, VF Kroll, D Russell, KJ AF Ginsberg, Mark D. Smith, Eddy D. VanBlaricum, Vicki Hock, Vincent F. Kroll, Dan Russell, Kevin J. BE Fountain III, AW Gardner, PJ TI Sensor-Enabled Chem/Bio Contamination Detection System Dedicated to Situational Awareness of Water Distribution Security Status SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI CY APR 06-08, 2010 CL Orlando, FL SP SPIE DE water supply; water distribution systems; drinking water; homeland security; contamination; corrosion AB Both real events and models have proven that drinking water systems are vulnerable to deliberate and/or accidental contamination. Additionally, homeland security initiatives and modeling efforts have determined that it is relatively easy to orchestrate the contamination of potable water supplies. Such contamination can be accomplished with classic and non-traditional chemical agents, toxic industrial chemicals (TICs), and/or toxic industrial materials (TIMs). Subsequent research and testing has developed a proven network for detection and response to these threats. The method uses off-the-shelf, broad-spectrum analytical instruments coupled with advanced interpretive algorithms. The system detects and characterizes any backflow events involving toxic contaminants by employing unique chemical signature (fingerprint) response data. This instrumentation has been certified by the Office of Homeland Security for detecting deliberate and/or accidental contamination of critical water infrastructure. The system involves integration of several mature technologies (sensors, SCADA, dynamic models, and the HACH HST Guardian Blue instrumentation) into a complete, real-time, management system that also can be used to address other water distribution concerns, such as corrosion. This paper summarizes the reasons and results for installing such a distribution-based detection and protection system. C1 [Ginsberg, Mark D.; Smith, Eddy D.; VanBlaricum, Vicki; Hock, Vincent F.] ERDC CERL, Champaign, IL 61822 USA. RP Ginsberg, MD (reprint author), ERDC CERL, 2902 Newmark Dr, Champaign, IL 61822 USA. EM edgar.d.smith@usace.army.mil NR 6 TC 0 Z9 0 U1 0 U2 7 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8129-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7665 AR 76651Q DI 10.1117/12.848389 PG 9 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSS35 UT WOS:000285626600053 ER PT S AU Guicheteau, J Tripathi, A Minter, J Wilcox, P Christesen, S AF Guicheteau, Jason Tripathi, Ashish Minter, Jennifer Wilcox, Phillip Christesen, Steven BE Fountain III, AW Gardner, PJ TI Fate Study of Water Borne Gram Positive Vegetative Bacterial Cells with Raman Microscopy SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI CY APR 06-08, 2010 CL Orlando, FL SP SPIE DE Raman; polyhydroxybuturic acid; Bacillus AB We present an initial bacterial fate study of Gram positive vegetative cells suspended in water and stored at ambient room temperature via Raman spectroscopy monitoring. Two types of cells were considered for this study: vegetative cells of Bacillus cereus, Bacillus thuringiensis which contain the polyhydroxybutyric acid (PHBA) as an energy storage compound and Bacillus subtlilis cells which do not. The cells were cultured specifically for this project. Immediately following the culturing phase, the bacteria were extracted, cleaned and at the onset of the study were suspended in de-ionized water and stored at room temperature. Aliquots of suspensions were deposited onto aluminum slides at different times and allowed to dry for Raman analysis. Spectra from multiple regions of each dried spot and each deposit time were acquired along with the bright-field and fluorescence images. Results were examined to investigate the effect of suspension time on the spectral signatures as well as the fate behavior of the three types of cells investigated. The cells were monitored daily for over a 14 period during which time the onset of starvation induced sporulation was observed. C1 [Guicheteau, Jason; Wilcox, Phillip; Christesen, Steven] USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Guicheteau, J (reprint author), USA, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8129-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7665 AR 766502 DI 10.1117/12.851147 PG 8 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSS35 UT WOS:000285626600002 ER PT S AU Holthoff, E Bender, J Pellegrino, P Fisher, A Stoffel, N AF Holthoff, Ellen Bender, John Pellegrino, Paul Fisher, Almon Stoffel, Nancy BE Fountain III, AW Gardner, PJ TI Photoacoustic Spectroscopy for Trace Vapor Detection and Molecular Discrimination SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XI SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI CY APR 06-08, 2010 CL Orlando, FL SP SPIE DE Photoacoustic spectroscopy; sensor; quantum cascade laser; MEMS ID QUANTUM CASCADE LASER; CHEMICAL SENSOR; MINIATURIZATION; INTEGRATION; CELL AB Photoacoustic spectroscopy (PAS) is a useful monitoring technique that is well suited for trace gas detection. This method routinely exhibits detection limits at the parts-per-million (ppm) or parts-per-billion (ppb) level for gaseous samples. PAS also possesses favorable detection characteristics when the system dimensions are scaled to a microsystem design. Current research utilizes quantum cascade lasers (QCLs) in combination with micro-electromechanical systems (MEMS)-scale photoacoustic cell designs. This sensing platform has provided favorable detection limits for a standard nerve agent simulant. The objective of the present work is to demonstrate an extremely versatile MEMS-scale photoacoustic sensor system that is able to discriminate between different analytes of interest. C1 [Holthoff, Ellen; Bender, John; Pellegrino, Paul] USA, Res Lab, Adelphi, MD 20783 USA. RP Holthoff, E (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 20 TC 1 Z9 1 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8129-0 J9 PROC SPIE PY 2010 VL 7665 AR 766510 DI 10.1117/12.850118 PG 7 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSS35 UT WOS:000285626600029 ER PT S AU Holthoff, EL Stratis-Cullum, DN Hankus, ME AF Holthoff, Ellen L. Stratis-Cullum, Dimitra N. Hankus, Mikella E. BE Fountain III, AW Gardner, PJ TI Xerogel-Based Molecularly Imprinted Polymers for Explosives Detection SO CHEMICAL, BIOLOGICAL, RADIOLOGICAL, NUCLEAR, AND EXPLOSIVES (CBRNE) SENSING XI SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) Sensing XI CY APR 06-08, 2010 CL Orlando, FL SP SPIE DE Molecular imprinting; SERS; xerogel; sensor; explosives ID ENHANCED RAMAN-SCATTERING; SELECTIVE DETECTION; SENSORS; TNT AB Molecularly imprinted polymers (MIPs) can be utilized as artificial recognition elements for target chemical analytes of interest. Molecular imprinting involves arranging polymerizable functional monomers around a template followed by polymerization and template removal. The selectivity for the target analyte is based on the spatial orientation of the binding site and covalent or noncovalent interactions between the functional monomer and the analyte. The polymer materials of particular interest are sol-gel-derived xerogels. To allow for increased target recognition, the xerogel has specific functional groups, which allow for polymer interactions with the template molecule (and target analyte). In a sensor format, the recognition event is monitored with some form of transduction. MIP technology is still in its infancy and limitations such as non-specific binding may be overcome utilizing surface enhanced Raman scattering (SERS) as an integrated transduction method for enhanced sensor performance. The objective of the present work is to create a sensitive and selective MIP-SERS sensing platform for 2,4,6-trinitrotoluene (TNT). C1 [Holthoff, Ellen L.; Stratis-Cullum, Dimitra N.; Hankus, Mikella E.] USA, Res Lab, Adelphi, MD 20783 USA. RP Holthoff, EL (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. RI Hankus, Mikella/A-9005-2012 NR 19 TC 4 Z9 4 U1 1 U2 16 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8129-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7665 AR 76650W DI 10.1117/12.850129 PG 9 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSS35 UT WOS:000285626600026 ER PT J AU Everley, PA Dillman, JF AF Everley, Patrick A. Dillman, James F., III TI A Large-Scale Quantitative Proteomic Approach To Identifying Sulfur Mustard-Induced Protein Phosphorylation Cascades SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID HUMAN EPIDERMAL-KERATINOCYTES; CELL-CYCLE REGULATION; MASS-SPECTROMETRY; DNA-DAMAGE; SACCHAROMYCES-CEREVISIAE; AMINO-ACIDS; IN-VIVO; KINASE; SILAC; CALMODULIN AB Sulfur mustard [SM, bis-(2-chloroethyl) sulfide] is a potent alkylating agent and chemical weapon. While there are no effective treatments for SM-induced injury, current research focuses on Understanding the Molecular changes upon SM exposure. Indeed, efforts that seek if more comprehensive analysis of proteins and post-translational modifications are critical for understanding SM-induced toxicity on a more global scale. Furthermore, these Studies Call uncover proteins previously uncharacterized in SM-exposed cells, which in turn leads to potential targets for therapeutic intervention. Here, We apply it quantitative proteomic approach termed stable isotope-labeling with amino acids in cell Culture combined with immobilized metal affinity chromatography to study the large-scale protein phosphorylation changes resulting front SM exposure in a human keratinocyte Cell culture model, This resulted in the characterization of over 2300 nonredundant phosphorylation sites, many of which exhibit altered levels in response to SM Our results point toward several proteins previously implicated in SM-induced toxicity as well its many additional proteins previously uncharacterized. Further de novo analysis of these phosphoproteins using interaction mapping software revealed both known and novel pathways that may Serve as future therapeutic targets of SM exposure. C1 [Everley, Patrick A.; Dillman, James F., III] USA, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA. RP Everley, PA (reprint author), USA, Med Res Inst Chem Def, Div Res, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM patrick.everley@us.army.mil FU U.S. Army; Defense Threat Reduction Agency-Joint Science and Technology Office, Medical ST Division FX Support for this work was provided by In-house Laboratory Independent Research funding from the U.S. Army (P.A.E.) as well as by the Defense Threat Reduction Agency-Joint Science and Technology Office, Medical S&T Division (J.F.D.). We thank members of the Dillman laboratory for insightful discussions and technical assistance, as well its S. Beausoleil and S. Gygi (Harvard Medical School, Boston, MA) for mass spectrometry analysis and phosphopeptide characterization. The opinions or assertions contained herein are the private views of the authors and are not to be construed its official or as reflecting the views of the Department of the Army or the Department of Defense. NR 31 TC 6 Z9 6 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD JAN PY 2010 VL 23 IS 1 BP 20 EP 25 DI 10.1021/tx900265z PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 543YU UT WOS:000273618500004 PM 19845377 ER PT J AU Bhattacharjee, AK Kuca, K Musilek, K Gordon, RK AF Bhattacharjee, Apurba K. Kuca, Kamil Musilek, Kamil Gordon, Richard K. TI In Silico Pharmacophore Model for Tabun-Inhibited Acetylcholinesterase Reactivators: A Study of Their Stereoelectronic Properties SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID CURRENTLY AVAILABLE OXIMES; CHOLINESTERASE REACTIVATORS; CRYSTAL-STRUCTURES; DESIGN; CONFORMATIONS; ANTIDOTES; OBIDOXIME; MECHANISM; EFFICACY; ANALOGS AB Organophosphorus (OP) nerve agents that inhibit acetylcholinesterase (AChE; EC 3.1.1.7) function in the nervous system, causing acute intoxication. If Untreated, death can result. Inhibited AChE call be reactivated by oximes, antidotes for OP exposure. However, OP intoxication caused by the nerve agent tabun (GA) is particularly resistant to oximes, which poorly reactivate GA-inhibited AChE. In an attempt to develop a rational strategy for the discovery and design of novel reactivators with lower toxicity and increased efficacy in reactivating GA-inhibited ACME, we developed the first in silico pharmacophore model for binding affinity of GA-inhibited AChE from a set of 11 oximes. Oximes were analyzed for stereoelectronic profiles and three-dimensional quantitative structure-activity relationship pharmacophores using ab initio quantum chemical and pharmacophore generation methods. Quantum chemical methods were sequentially used from semiempirical AM1 to hierarchical ab initio Calculations to determine the stereoelectronic properties of nine oximes exhibiting affinity for binding to GA-inhibited AChE in vivo. The Calculated stereoelectronic properties led US to develop the in silico pharmacophore model using CATALYST methodology. Specific stereoelectronic profiles including the distance between bisquarternary nitrogen atoms of the pyridinium ring in the oximes, hydrophilicity, surface area, nucleophilicity of the oxime oxygen, and location of the molecular orbitals on the isosurfaces have important roles for potencies for reactivating GA-inhibited AChE. The in silico pharmacophore model of oxime affinity for binding to GA-inhibited AChE was found to require a hydrogen bond acceptor, a hydrogen bond donor at the two terminal regions, and in aromatic ring in the central region of the oximes. The model was found to be well-correlated (R = 0.9) With experimental oxime affinity for binding to GA-inhibited AChE. Additional sterectelectronic features relating activity with the location of molecular orbitals and weak electrostatic potential field over the aromatic rings were, found to be consistent with the pharmacophore model. These results provided the first predictive pharmacophore model of oxime affinity for binding toward GA-inhibited AChE. The model may be Useful for virtual screening of compound libraries to discover and/or custom synthesize more efficacious and less toxic reactivators that may be useful for GA intoxication. C1 [Bhattacharjee, Apurba K.; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, Silver Spring, MD 20910 USA. [Bhattacharjee, Apurba K.; Gordon, Richard K.] Fac Mil Hlth Sci, Ctr Adv Studies, Hradec Kralove 1575, Czech Republic. [Kuca, Kamil] Fac Mil Hlth Sci, Dept Toxicol, Hradec Kralove 1575, Czech Republic. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Regulated Labs, Div Regulated Act, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Apurba.Bhattacharjee@amedd.army.mil RI Kuca, Kamil/D-1396-2011; OI Kuca, Kamil/0000-0001-9664-1109; Musilek, Kamil/0000-0002-7504-4062 FU DTRA [1 E0057_08_WR_C] FX Material has been reviewed by the Walter Reed Army Institute of Research. There, is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private Views of the authors and are not to be construed as official or reflecting true views of the Department of the Army or the Department of Defense. We express sincere thanks to Sonia Thangavelu for drawing the figures and Dr. Shaliza Somerville For help in the manuscript preparation. Funding from DTRA (#1 E0057_08_WR_C) is gratefully acknowledged. NR 40 TC 17 Z9 17 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD JAN PY 2010 VL 23 IS 1 BP 26 EP 36 DI 10.1021/tx900192u PG 11 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA 543YU UT WOS:000273618500005 PM 20028185 ER PT J AU Walsh, ME Taylor, S Hewitt, AD Walsh, MR Ramsey, CA Collins, CM AF Walsh, Marianne E. Taylor, Susan Hewitt, Alan D. Walsh, Michael R. Ramsey, Charles A. Collins, Charles M. TI Field observations of the persistence of Comp B explosives residues in a salt marsh impact area SO CHEMOSPHERE LA English DT Article DE RDX; TNT; Energetic materials; Dissolution; Military training; Low-order detonation ID AIR WEAPONS RANGE; DISSOLUTION RATES; TNT; RDX; TRANSPORT; FLOW AB Field observations of weathering Comp B (RDX/TNT 60/40) residue were made on a live-fire training range over four years. The Comp B residue was formed by low-order detonations of 120-mm mortar projectiles. Physical changes were the disaggregation of initially solid chunks into masses of smaller diameter pieces and formation of red phototransformation products that washed off with rain or tidal flooding. Disaggregation increased the surface area of the residue, thereby increasing the potential for dissolution. The bulk of the mass of Comp B was in the craters, but solid chunks were scattered asymmetrically up to 30 m away. Published by Elsevier Ltd. C1 [Walsh, Marianne E.; Taylor, Susan; Hewitt, Alan D.; Walsh, Michael R.; Collins, Charles M.] USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Ramsey, Charles A.] Enivrostat Inc, Ft Collins, CO 80522 USA. RP Walsh, ME (reprint author), USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Marianne.E.Walsh@usace.army.mil FU US Army Garrison Alaska; Strategic Environmental Research and Development Program FX Funding for this research was provided by the US Army Garrison Alaska, under the sponsorship of Gary Larsen, and the Strategic Environmental Research and Development Program, Dr. Jeffrey Marqusee, Technical Director. NR 18 TC 15 Z9 16 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JAN PY 2010 VL 78 IS 4 BP 467 EP 473 DI 10.1016/j.chemosphere.2009.10.021 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 550CL UT WOS:000274105700018 PM 19883934 ER PT S AU White, JW Hoogenboom, G AF White, Jeffrey W. Hoogenboom, Gerrit BE Lobell, D Burke, M TI Crop Response to Climate: Ecophysiological Models SO CLIMATE CHANGE AND FOOD SECURITY: ADAPTING AGRICULTURE TO A WARMER WORLD SE Advances in Global Change Research LA English DT Article; Book Chapter ID CULTIVAR COEFFICIENTS; PERFORMANCE TRIALS; SIMULATION-MODELS; CARBON-DIOXIDE; GENETIC COEFFICIENTS; AGRICULTURAL CROPS; ELEVATED CO2; GROWTH-MODEL; WHEAT; IMPACT AB To predict the possible impacts of global warming and increased CO(2) on agriculture, scientists use computer-based models that attempt to quantify the best-available knowledge on plant physiology, agronomy, soil science and meteorology in order to predict how a plant will grow under specific environmental conditions. The chapter reviews the basic features of crop models with emphasis on physiological responses to temperature and CO(2) and explains how models are used to predict potential impacts of climate change, including options for adaptation. The closing section reviews major issues affecting the reliability of model-based predictions. These include the need for accurate inputs, the challenges of improving the underlying physiological knowledge, and the need to improve representations of genetic variation that likely will affect adaptation to climate change. C1 [White, Jeffrey W.] USA, Land Agr Res Ctr, USDA ARS, Maricopa, AZ 85224 USA. [Hoogenboom, Gerrit] Univ Georgia, Griffin, GA 30223 USA. RP White, JW (reprint author), USA, Land Agr Res Ctr, USDA ARS, 21881 N Cardon Lane, Maricopa, AZ 85224 USA. EM jeffrey.white@ars.usda.gov; Gerrit@uga.edu NR 76 TC 9 Z9 9 U1 1 U2 10 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1574-0919 BN 978-90-481-2951-5 J9 ADV GLOB CHANGE RES JI Adv. Glob. Change Res. PY 2010 VL 37 BP 59 EP 83 DI 10.1007/978-90-481-2953-9_4 PG 25 WC Agricultural Economics & Policy; Environmental Sciences; Environmental Studies; Planning & Development SC Agriculture; Environmental Sciences & Ecology; Public Administration GA BMQ42 UT WOS:000273346700004 ER PT S AU Stockton, SL White, KD AF Stockton, S. L. White, K. D. BE Linkov, I Bridges, TS TI US Army Corps of Engineers' Collaborative Approach to Twenty-First Century Challenges Posed by Global Change SO CLIMATE: GLOBAL CHANGE AND LOCAL ADAPTATION SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Global Climate Change and Local Adaptation CY JUN 06-10, 2010 CL Hella, ICELAND SP NATO ID WATER-RESOURCES; CLIMATE-CHANGE; CONFLICT AB It is now clear that global changes, including demographic shifts, changing land use/land cover, climate change, and changing social values and economic conditions, are part of a complex system that cannot effectively be dealt with by piecemeal or sequential problem-solving. These changes can interact and combine in unpredictable ways, resulting in potentially surprising or abrupt changes that threaten public health and safety, the performance of water resources infrastructure, and the functioning of ecosystems. The U.S. Army Corps of Engineers (USACE) sees these global changes that result in local impacts and responses as the major challenge of the twenty-first century. We also recognize that close collaboration, both nationally and internationally, is the most effective way to develop practical, nationally consistent, and cost-effective measures to reduce potential vulnerabilities resulting from global changes. This paper will discuss how USACE is leading the way to solve the challenges of the twenty-first century through our collaborative approach. C1 [Stockton, S. L.] US Army Corps Engineers, 441 G St NW, Washington, DC USA. [White, K. D.] US Army Corps Engineers, Inst Water Resources, Hanover, NH 03755 USA. RP Stockton, SL (reprint author), US Army Corps Engineers, 441 G St NW, Washington, DC USA. EM Steven.L.Stockton@usace.army.mil; Kathleen.D.White@usace.army.mil NR 38 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-94-007-1769-5 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2010 BP 19 EP + DI 10.1007/978-94-007-1770-1_3 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA BBM95 UT WOS:000307436500003 ER PT S AU Linkov, I Bates, M Loney, D Sparrevik, M Bridges, T AF Linkov, I. Bates, M. Loney, D. Sparrevik, M. Bridges, T. BE Linkov, I Bridges, TS TI Risk Management Practices Cross-Agency Comparisons and Tolerable Risk SO CLIMATE: GLOBAL CHANGE AND LOCAL ADAPTATION SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Global Climate Change and Local Adaptation CY JUN 06-10, 2010 CL Hella, ICELAND SP NATO ID TOOL AB The inevitable public unease in the wake of large infrastructure failure prompts questions regarding how to properly define and manage the risks of various engineered activities to socially acceptable levels. A changing climate may add additional vulnerability to infrastructure and thus should be considered in risk management strategies. Current implementations of risk management processes differ across public agencies, but often rely on a concept of Tolerable Risk. Tolerable Risk is a numerical value for the boundary-in a continuum of management alternatives-below which risk is tolerated to secure societal benefits, though engineering interventions may be still be necessary and proper to achieve higher degrees of protection. This chapter gives an overview of risk management and introduces the Tolerable Risk framework, reviews and summarizes risk management frameworks for several federal and foreign agencies, and recommends key features and necessary steps for a Tolerable Risk framework implementation. The ideas in this chapter draw extensively from a March 2008 inter-agency workshop on Tolerable Risk sponsored by the U.S. Army Corps of Engineers, the U.S. Bureau of Reclamation, and the Federal Energy Regulatory Commission, and attended by several additional federal and foreign agencies [33]. C1 [Linkov, I.; Bates, M.; Loney, D.; Bridges, T.] USACE Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. [Bates, M.] US Army Corps of Engineers, Engineer Res & Dev Ctr, Environm Lab, Washington, DC USA. [Sparrevik, M.] Norwegian Univ Technol & Sci, Dept Ind Econom & Technol, Trondheim, Norway. RP Linkov, I (reprint author), USACE Engn Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA. EM Igor.Linkov@usace.army.mil FU US Army Corps of Engineers Civil Works Program FX This study was funded in part by the US Army Corps of Engineers Civil Works Program. Permission was granted by the Chief of Engineers to publish this information.The view sand opinions expressed here are those of the individual authors and not those of the U.S. Army Corps of Engineers. Thanks are due the anonymous referees who provided useful commentary and suggestions on an earlier draft of this paper. Any errors are, of course, our own. The authors are grateful to David Bowles (Utah University) and David Moser and Todd Bridges (US Army Corps of Engineers) for fruitful discussions and support of this effort. NR 57 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-94-007-1769-5 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2010 BP 133 EP + DI 10.1007/978-94-007-1770-1_8 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA BBM95 UT WOS:000307436500008 ER PT S AU Russo, EJ McBride, B Bennett, E Bjornsson, H Brklacich, M Bromberg, G Butte, G Geiss, K Lewis, K Merad, M Nyer, R Tkachuk, A AF Russo, E. J., Jr. McBride, B. Bennett, E. Bjornsson, H. Brklacich, M. Bromberg, G. Butte, G. Geiss, K. Lewis, K. Merad, M. Nyer, R. Tkachuk, A. BE Linkov, I Bridges, TS TI National Security Perspectives on Addressing Instabilities Arising from Climate Change Impacts on the Environment SO CLIMATE: GLOBAL CHANGE AND LOCAL ADAPTATION SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Global Climate Change and Local Adaptation CY JUN 06-10, 2010 CL Hella, ICELAND SP NATO AB Societal stability and the security of peoples can be threatened in subtle, complex, and profound ways by the effects of global climate change on the environment. Stresses due to climate change on the quality, quantity, and distribution of environmental resources accessible by nations and regional communities often multiply security threats. Active security concerns can become heightened in these conditions. New security issues have potential to emerge with mobilization of new or latent stressors. Contemplating science-based, plausible climate change futures that have potential for impact provides context for anticipating environmental security tipping points. Examination of historical environmental security risk analogs facilitates synthesis of knowledge for adapting to climate changes in ways that maintain and restore global environmental security conditions. National security agencies of governments equipped with this knowledge increase their potential to effectively identify, prepare, and apply measures to address climate change environmental issues on a timely basis to save lives, conserve natural resources, reduce international tensions, and build global trust. C1 [Russo, E. J., Jr.] USA, Ecosyst Evaluat & Engn Div, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. [McBride, B.] US Navy, US Navy Task Force Climate Change, Off Oceanographer, Washington, DC USA. [Bennett, E.] Bioengineering, Toronto, ON, Canada. [Bjornsson, H.] Icelandic Meteorol Off, Climate Change Res Grp, Reykjavik, Iceland. [Brklacich, M.] Carleton Univ, Ottawa, ON, Canada. [Bromberg, G.] Friends Earth Middle East, Amman, Israel. [Butte, G.] Decision Partners, Reston, VA USA. [Geiss, K.] US Army, Energy Secur, Washington, DC USA. [Lewis, K.] Hadley Ctr, Met Off, Devon, England. [Merad, M.] INERIS, Verneuil Halatte, Picardie, France. [Nyer, R.] RNC Conseil, Neuilly Sur Seine, France. [Tkachuk, A.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA. RP Russo, EJ (reprint author), USA, Ecosyst Evaluat & Engn Div, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM edmond.j.russo@usace.army.mil NR 14 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-94-007-1769-5 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2010 BP 259 EP + DI 10.1007/978-94-007-1770-1_14 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA BBM95 UT WOS:000307436500014 ER PT S AU Tkachuk, A Collier, Z Travleev, A Levchenko, V Levchenko, A Kazansky, Y Parad, S Linkov, I AF Tkachuk, A. Collier, Z. Travleev, A. Levchenko, V. Levchenko, A. Kazansky, Y. Parad, S. Linkov, I. BE Linkov, I Bridges, TS TI Energy Security: Using Multicriteria Decision Analysis to Select Power Supply Alternatives for Small Settlements SO CLIMATE: GLOBAL CHANGE AND LOCAL ADAPTATION SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Global Climate Change and Local Adaptation CY JUN 06-10, 2010 CL Hella, ICELAND SP NATO ID MANAGEMENT; RISK; SYSTEMS; DESIGN; PLANTS; SITES AB Selecting an effective energy strategy for military installations and small towns is a challenge given the variety of climate, geographical, economic, and social conditions as well as military mission needs. This chapter illustrates a multicriteria decision analysis (MCDA) framework for energy infrastructure planning and technology selection that can be applied to energy security, climate change impacts, and other related uncertainties. The decision model frames the problem in terms of the power plant life cycle, including plant development, commissioning, operation, and decommissioning. Metrics associated with technical, economic, sociopolitical, ecological, and human health risks are considered for each life cycle stage. These criteria and metrics are developed and quantified based on available literature data and expert judgments, and are applied to a realistic case study. C1 [Tkachuk, A.; Collier, Z.; Linkov, I.] USA, Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA USA. [Travleev, A.] Karlsruhe Inst Technol, Inst Neutron Phys & Reactor Technol, Karlsruhe, Germany. [Levchenko, V.; Levchenko, A.] Simulat Syst Ltd, Obninsk, Russia. [Kazansky, Y.] Obninsk State Tech Univ Nucl Power Engn, Obninsk, Russia. [Parad, S.] Swiss Fed Inst Technol, Inst Environm Decis, Nat & Social Sci Interface, Zurich, Switzerland. RP Linkov, I (reprint author), USA, Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA USA. EM igor.linkov@usace.army.mil FU U.S. Army Engineer Research and Development Center; Department of Army Installation Technology Transfer Program FX The authors are grateful to Christopher Karvetski and Matthew Bates for their review and suggestions. This effort was sponsored in part by the USACE Civil Works Basic Research Program by the U.S. Army Engineer Research and Development Center and the Department of Army Installation Technology Transfer Program. Permission was granted by the USACE Chief of Engineers to publish this material. The views and opinions expressed in this paper are those of the individual authors and not those of the U.S. Army, or other sponsor organizations. NR 69 TC 0 Z9 0 U1 0 U2 4 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-94-007-1769-5 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2010 BP 311 EP + DI 10.1007/978-94-007-1770-1_18 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA BBM95 UT WOS:000307436500018 ER PT S AU Lozar, RC Hiett, MD Westervelt, JD AF Lozar, R. C. Hiett, M. D. Westervelt, J. D. BE Linkov, I Bridges, TS TI Climate Change Impacts and Adaptation on CONUS Military Installations SO CLIMATE: GLOBAL CHANGE AND LOCAL ADAPTATION SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Global Climate Change and Local Adaptation CY JUN 06-10, 2010 CL Hella, ICELAND SP NATO ID SOIL-EROSION; UNITED-STATES; PRECIPITATION; ECOREGIONS; MODEL; SENSITIVITY; DELINEATION; INTENSITY; RESPONSES; RAINFALL AB Military installations must be maintained and managed to provide appropriate training and testing opportunities. As climate changes, natural areas on installations may shift, and the costs to maintain training and testing areas may change. This chapter looks across continental U.S. (CONUS) installations with respect to the habitat and erosion consequences associated with climate forecasts from four Global Climate Models (GCMs). Habitat is important from two perspectives: its ability to support training and testing, and its capacity to meet federal requirements regarding the maintenance of listed threatened and endangered species. That capacity can change due to shifts in weather patterns, flooding, drought potential, and annual temperature patterns. With substantial change, species can be directly affected by invasive species, loss and fragmentation of habitat, or increased disease and predation. Population losses for these species can result in loss of training lands and/or time. Additionally, climate change might result in changes in erosion patterns and intensity, which can also directly affect training. This chapter begins an exploration of how climate change forecasts can be converted to forecasts regarding potential challenges to habitats and species and potential impacts on erosion at each of about 130 CONUS installations. The chapter concludes with recommendations on how to adapt to these changes. C1 [Lozar, R. C.; Hiett, M. D.; Westervelt, J. D.] USA, Engineers Res & Dev Ctr, Champaign, IL 61821 USA. RP Westervelt, JD (reprint author), USA, Engineers Res & Dev Ctr, 2009 Newmark Dr, Champaign, IL 61821 USA. EM james.d.westervelt@usace.army.mil NR 36 TC 0 Z9 0 U1 1 U2 5 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-94-007-1769-5 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2010 BP 333 EP 371 DI 10.1007/978-94-007-1770-1_19 PG 39 WC Environmental Sciences SC Environmental Sciences & Ecology GA BBM95 UT WOS:000307436500019 ER PT S AU Dalton, JC Brown, TA Pietrowsky, RA White, KD Olsen, JR Arnold, JR Giovannettone, JP Brekke, LD Raff, DA AF Dalton, J. C. Brown, T. A. Pietrowsky, R. A. White, K. D. Olsen, J. R. Arnold, J. R. Giovannettone, J. P. Brekke, L. D. Raff, D. A. BE Linkov, I Bridges, TS TI US Army Corps of Engineers Approach to Water Resources Climate Change Adaptation SO CLIMATE: GLOBAL CHANGE AND LOCAL ADAPTATION SE NATO Science for Peace and Security Series C-Environmental Security LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Global Climate Change and Local Adaptation CY JUN 06-10, 2010 CL Hella, ICELAND SP NATO ID WESTERN NORTH-AMERICA; CALIFORNIA AB The magnitude of climate change impacts facing water resources managers in the United States has spurred closer interagency cooperation in developing methods supporting planning and engineering for climate change adaptation. The two largest water resources management agencies in the U.S., the U.S. Army Corps of Engineers and the Bureau of Reclamation, have partnered to describe climate change challenges, identify user needs for improving tools and information, and assess capabilities to use weather and climate forecasts in federal water resources management. They have also hosted a forum with national and international experts exploring the issue of nonstationary hydrology with respect to climate change. In progress is development of multiagency guidelines for best practices to select from the portfolio of climate information including global climate scenarios, through general circulation models, through downscaling, to regional or watershed-scale hydrological and operations planning models to account properly for climate change and variability at the scale of water-resource operational decisions. This presentation describes collaborative activities and the resulting methods being used as both agencies plan for and implement climate change adaptation measures. C1 [Dalton, J. C.; Brown, T. A.] US Army Corps Engineers, 441 G St NW, Washington, DC USA. [Pietrowsky, R. A.; White, K. D.; Olsen, J. R.; Arnold, J. R.; Giovannettone, J. P.] US Army Corps Engineers, Inst Water Resources, Washington, DC USA. [Brekke, L. D.] US Bureau Reclamat, Tech Serv Ctr, Washington, DC USA. [Raff, D. A.] US Bureau Reclamat, Policy and Adm, Washington, DC USA. RP Dalton, JC (reprint author), US Army Corps Engineers, 441 G St NW, Washington, DC USA. EM James.C.Dalton@usace.army.mil NR 33 TC 1 Z9 1 U1 0 U2 3 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1871-4668 BN 978-94-007-1769-5 J9 NATO SCI PEACE SECUR JI NATO Sci. Peace Secur. Ser. C- Environ. Secur. PY 2010 BP 401 EP + DI 10.1007/978-94-007-1770-1_21 PG 4 WC Environmental Sciences SC Environmental Sciences & Ecology GA BBM95 UT WOS:000307436500021 ER PT J AU Kellogg, M Hollis, M Gauthier, C O'Brien, T AF Kellogg, Mark Hollis, Mark Gauthier, Cheryl O'Brien, Tom TI Detection of Biological Agents Used for Terrorism: Are We Ready? SO CLINICAL CHEMISTRY LA English DT Editorial Material C1 [Kellogg, Mark] Childrens Hosp, Boston, MA 02115 USA. [Kellogg, Mark] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. [Hollis, Mark] MIT, Lincoln Lab, Lexington, MA 02173 USA. [Gauthier, Cheryl] MIT, Dept Publ Hlth, Bioterrorism Response Lab, Boston, MA USA. [O'Brien, Tom] Tetracore Inc, Rockville, MD USA. [O'Brien, Tom] USN, Naval Med Res Inst, Dept Immunol, Biol Def Res Programg, Bethesda, MD 20084 USA. RP Kellogg, M (reprint author), Childrens Hosp, 300 Longwood Ave, Boston, MA 02115 USA. OI Kellogg, Mark/0000-0003-1868-2153 NR 0 TC 3 Z9 3 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JAN PY 2010 VL 56 IS 1 BP 10 EP 15 DI 10.1373/clinchem.2009.139493 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 542BM UT WOS:000273466300004 PM 19926772 ER PT J AU Brady, DE Torres, DM An, JW Ward, JA Lawitz, E Harrison, SA AF Brady, Daniel E. Torres, Dawn M. An, Jong W. Ward, John A. Lawitz, Eric Harrison, Stephen A. TI Induction Pegylated Interferon Alfa-2b in Combination With Ribavirin in Patients With Genotypes 1 and 4 Chronic Hepatitis C: A Prospective, Randomized, Multicenter, Open-Label Study SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article ID NON-B HEPATITIS; SUSTAINED VIROLOGICAL RESPONSE; PLACEBO-CONTROLLED TRIAL; ALPHA-2B PLUS RIBAVIRIN; PEGINTERFERON ALPHA-2B; INSULIN-RESISTANCE; NON-A; INITIAL TREATMENT; VIRAL CLEARANCE; UNITED-STATES AB BACKGROUND & AIMS: Standard of care (SOC) treatment for chronic hepatitis C (CHC) involves weekly pegylated (PEG) interferon plus weight-based ribavirin with resultant sustained virologic response (SVR) rates at or near 50% for genotypes 1 and 4 virus. Induction therapy with higher doses of PEG interferon may improve first-phase viral kinetics and thus improve the overall SVR in genotypes 1 and 4 patients. METHODS: This multicenter, randomized, open-label trial enrolled treatment-naive genotypes 1- and 4-infected CHC patients to either initial induction therapy versus SOC. The induction group received PEG interferon alfa-2b 3.0 mcg/kg/wk for 12 weeks followed by PEG interferon alfa-2b 1.5 mcg/kg/wk for 36 weeks and 13 +/- 2 mg/kg ribavirin daily for 48 weeks. SOC patients received PEG interferon alfa-2b 1.5 mcg/kg weekly for 48 weeks and 13 +/- 2 mg/kg ribavirin daily for 48 weeks. The primary end point was SVR. RESULTS: There were 610 patients enrolled throughout the United States. Complete early virologic response was 62.6% versus 57.7% in induction versus SOC (NS). Overall SVR was 32% in induction versus 29% in SOC group (NS). Dose reduction of either PEG interferon (24.1% vs 23.8%) or ribavirin (26.8% vs 25.1%) was similar between the 2 groups. There was a trend toward a significant difference when comparing the SVR in induction therapy in patients weighing more than 85 kg versus those receiving SOC (38% vs 28%; P = .08). CONCLUSIONS: Induction therapy does not enhance complete early virologic response or SVR rates in a predominantly genotype 1 CHC population compared with SOC therapy. C1 [Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. [Lawitz, Eric] Alamo Med Res, San Antonio, TX USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA. EM stephen.harrison@amedd.army.mil FU Schering Plough (Kenilworth, NJ) FX Supported by an unrestricted grant from Schering Plough (Kenilworth, NJ). Schering Plough had no role in the study design; the collection, analysis, and interpretation of the data; or in the decision to submit the report for publication. NR 31 TC 9 Z9 9 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD JAN PY 2010 VL 8 IS 1 BP 66 EP 71 DI 10.1016/j.cgh.2009.08.036 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 592ZO UT WOS:000277420800016 PM 19747986 ER PT J AU Fitzpatrick, KF AF Fitzpatrick, Kevin F. TI Cyclists - Ulnar Nerve Neuropathy and Double Crush SO CLINICAL JOURNAL OF SPORT MEDICINE LA English DT Letter ID CARPAL-TUNNEL SYNDROME; COMPRESSION C1 Walter Reed Army Med Ctr, PM&R Electrodiagnost Lab, Washington, DC 20307 USA. RP Fitzpatrick, KF (reprint author), Walter Reed Army Med Ctr, PM&R Electrodiagnost Lab, Washington, DC 20307 USA. NR 12 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1050-642X J9 CLIN J SPORT MED JI Clin. J. Sport Med. PD JAN PY 2010 VL 20 IS 1 BP 69 EP 70 PG 2 WC Orthopedics; Physiology; Sport Sciences SC Orthopedics; Physiology; Sport Sciences GA 542ON UT WOS:000273504100013 PM 20051739 ER PT J AU Loh, Y Hinds, SR AF Loh, Yince Hinds, Sidney R., II TI Serial PET Changes of Extraocular Muscle Hypermetabolism in Sporadic Fatal Insomnia SO CLINICAL NUCLEAR MEDICINE LA English DT Editorial Material DE prion; sporadic fatal insomnia; PET; thalamic; hypometabolism; extraocular muscles ID CREUTZFELDT-JAKOB-DISEASE; FAMILIAL INSOMNIA; DEMENTIA AB The chronological development of positron emission tomography abnormalities in prion disease is unclear. A 44-year-old man with no significant family history presented with cognitive difficulties, paranoia, and insomnia. He had prominent saccadic intrusions and a lurching gait. Cell count, metabolic panel, copper, thyroid, and urine heavy metals were normal. Cerebrospinal 14-3-3 and antithyroid antibodies were not detected. Positron emission tomography demonstrated decreased thalamic F-18 fluorodeoxyglucose uptake. Over months, cortical metabolism decreased while uptake increased in the extraocular muscles. Eighteen months later, the patient aspirated and died. Hypermetabolism of the extraocular muscles reflects increased motor activity from continuous saccades, which results from loss of cortical fixation. C1 [Loh, Yince] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. [Hinds, Sidney R., II] Walter Reed Army Med Ctr, Dept Radiol, Washington, DC 20307 USA. RP Loh, Y (reprint author), Madigan Army Med Ctr, Neurol Serv, Dept Med, Bldg 9040,Fitzsimmons Dr, Tacoma, WA 98431 USA. EM yincer@yahoo.com NR 8 TC 0 Z9 0 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JAN PY 2010 VL 35 IS 1 BP 47 EP 48 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 540MR UT WOS:000273336500016 PM 20026978 ER PT J AU Sheehan, FT Derasari, A Fine, KM Brindle, TJ Alter, KE AF Sheehan, Frances T. Derasari, Aditya Fine, Kenneth M. Brindle, Timothy J. Alter, Katharine E. TI Q-angle and J-sign Indicative of Maltracking Subgroups in Patellofemoral Pain SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID ANTERIOR KNEE PAIN; IN-VIVO; TIBIOFEMORAL KINEMATICS; PHYSICAL-EXAMINATION; PATELLAR TRACKING; ALIGNMENT; JOINT; WOMEN; INDIVIDUALS; RELIABILITY AB Mechanical factors related to patellofemoral pain syndrome and maltracking are poorly understood. Clinically, the Q-angle, J-sign,and lateral hypermobility commonly are used to evaluate patellar maltracking. However, these measures have yet to be correlated to specific three-dimensional patellofemoral displacements and rotations. Thus, we tested the hypotheses that increased Q-angle, lateral hypermobility, and J-sign correlate with three-dimensional patellofemoral displacements and rotations. We also determined whether multiple maltracking patterns can be discriminated, based on patellofemoral displacements and rotations. Three-dimensional patellofemoral motion data were acquired during active extension-flexion using dynamic MRI in 30 knees diagnosed with patellofemoral pain and at least one clinical sign of patellar maltracking (Q-angle, lateral hypermobility, or J-sign) and in 37 asymptomatic knees. Although the Q-angle is assumed to indicate lateral patellar subluxation, our data supported a correlation between the Q-angle and medial, not lateral, patellar displacement. We identified two distinct maltracking groups based on patellofemoral lateral-medial displacement, but the same groups could not be discriminated based on standard clinical measures (eg, Q-angle, lateral hypermobility, and J-sign). A more precise definition of abnormal three-dimensional patellofemoral motion, including identifying subgroups in the patellofemoral pain population, may allow more targeted and effective treatments. C1 [Sheehan, Frances T.; Brindle, Timothy J.; Alter, Katharine E.] NIH, Dept Rehabil Med, Bethesda, MD 20892 USA. [Derasari, Aditya] Univ Miami, Dept Orthopaed, Miami, FL USA. [Fine, Kenneth M.] Orthopaed Ctr, Rockville, MD USA. [Brindle, Timothy J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Alter, Katharine E.] Mt Washington Pediat Hosp, Baltimore, MD USA. RP Sheehan, FT (reprint author), NIH, Dept Rehabil Med, Bldg 10 CRC,Room 1-1469,10 Ctr Dr MSC 1604, Bethesda, MD 20892 USA. EM fsheehan@cc.nih.gov RI sheehan, frances/B-6962-2009 FU Diagnostic Radiology Department at the National Institutes of Health FX We thank Ching-yi Shieh, PhD, and Elizabeth K. Rasch, PT, PhD, for support on the statistical analysis and Steven Stanhope, PhD, for guidance throughout the project. We also thank Bonnie Damaska, Jamie Fraunhaffer, Jere McLucas, Dr. Barry Boden, and the Diagnostic Radiology Department at the National Institutes of Health for their support and research time. NR 51 TC 18 Z9 18 U1 0 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JAN PY 2010 VL 468 IS 1 BP 266 EP 275 DI 10.1007/s11999-009-0880-0 PG 10 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 558SU UT WOS:000274767200039 PM 19430854 ER PT J AU O'Neal, S Potter, BK Adams, SC Pitcher, JD AF O'Neal, Scott Potter, Benjamin K. Adams, Sheila C. Pitcher, J. David, Jr. TI A Slow-growing Anterior Tibial Mass in a 37-year-old Woman SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID MYCETOMA; FEATURES C1 [O'Neal, Scott; Adams, Sheila C.; Pitcher, J. David, Jr.] Univ Miami, Jackson Mem Hosp, Dept Orthopaed, Miami, FL 33101 USA. [Potter, Benjamin K.] Walter Reed Army Med Ctr, Orthopaed Surg Serv, Washington, DC 20307 USA. RP O'Neal, S (reprint author), Univ Miami, Jackson Mem Hosp, Dept Orthopaed, POB 016960 D-27, Miami, FL 33101 USA. EM soneal@med.miami.edu NR 11 TC 2 Z9 2 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JAN PY 2010 VL 468 IS 1 BP 302 EP 306 DI 10.1007/s11999-009-0893-8 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 558SU UT WOS:000274767200044 PM 19452235 ER PT J AU Heckler, AK Shmorhun, D AF Heckler, Alan K. Shmorhun, Daniel TI Asymptomatic, Transient Complete Heart Block in a Pediatric Patient with Lyme Disease SO CLINICAL PEDIATRICS LA English DT Article DE Lyme disease; Lyme carditis; complete heart block; third degree heart block; pediatric patient ID CHILDREN AB Lyme Disease, caused by the spirochete Borrellia burgdorferi, is the most common vector-borne disease in the United States. Clinically, it primarily affects the skin, joints, nervous system, and heart. Lyme carditis occurs in 4%-10% of adults with Lyme disease. Transient variable-level atrioventricular blocks, occurring in 77% of adults with Lyme carditis, are the most common cardiac manifestation. Up to 50% of Lyme carditis patients may develop complete heart block. The incidence of Lyme carditis in the pediatric population is not well established. We present a pediatric patient with a transient asymptomatic complete heart block resulting from Lyme carditis, an under-recognized complication of Lyme disease in the pediatric population. C1 [Heckler, Alan K.; Shmorhun, Daniel] Walter Reed Army Med Ctr, Natl Capitol Mil Childrens Ctr, Washington, DC 20307 USA. RP Heckler, AK (reprint author), 6900 Georgia Ave NW, Washington, DC 20307 USA. EM alan.heckler@nccpeds.com NR 10 TC 0 Z9 0 U1 0 U2 1 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD JAN PY 2010 VL 49 IS 1 BP 82 EP 85 DI 10.1177/0009922808330784 PG 4 WC Pediatrics SC Pediatrics GA 537EF UT WOS:000273095100016 PM 19190204 ER PT J AU Burns, JW Sondeen, JL Prince, MD Estep, JS Dubick, MA AF Burns, John W. Sondeen, Jill L. Prince, M. Dale Estep, J. Scot Dubick, Michael A. TI Influence of asymptomatic pneumonia on the response to hemorrhage and resuscitation in swine SO CLINICS LA English DT Article DE Controlled Hemorrhage; Resuscitation; Cardiac Output; Physiologic Reserve; Immature Domestic Swine ID UNCONTROLLED HEMORRHAGE; VOLUME RESUSCITATION; SHOCK; INJURY; MODEL; PRESSURE AB INTRODUCTION: Investigation of resuscitation fluids in our swine hemorrhage model revealed moderate to severe chronic pneumonia in five swine at necropsy. Our veterinary staff suggested that we perform a retrospective analysis of prospectively collected data from these animals. We compared the data to that of ten healthy swine to determine the physiologic consequences of the added stress on our hemorrhage/resuscitation model. METHODS: Anesthetized, immature female swine (40 +/- 5 kg) were instrumented for determining arterial and venous pressures, cardiac output and urine production. A controlled hemorrhage of 20 ml/kg over 4 min 40 sec was followed at 30 min by a second hemorrhage of 8 ml/kg and resuscitation with 1.5 ml/kg/min of LR solutions to achieve and maintain systolic blood pressure at 80 +/- 5 mmHg for 3.5 hrs. Chemistries and arterial and venous blood gasses were determined from periodic blood samples along with hemodynamic variables. RESULTS: There were significant decreases in survival, urine output, cardiac output and oxygen delivery at 60 min and O(2) consumption at 120 min in the pneumonia group compared to the non-pneumonia group. There were no differences in other metabolic or hemodynamic data between the groups. CONCLUSION: Although pneumonia had little influence on pulmonary gas exchange, it influenced cardiac output, urine output and survival compared to healthy swine, suggesting a decrease in the physiologic reserve. These data may be relevant to patients with subclinical infection who are stressed by hemorrhage and may explain in part why some similarly injured patients require more resuscitation efforts than others. C1 [Burns, John W.; Sondeen, Jill L.; Prince, M. Dale; Estep, J. Scot; Dubick, Michael A.] USA, Inst Surg Res, San Antonio, TX USA. RP Burns, JW (reprint author), USA, Inst Surg Res, San Antonio, TX USA. EM michael.dubick@amedd.army.mil FU U.S. Army Medical Research and Materiel Command; U.S. Army Institute of Surgical Research FX This study was supported by the U.S. Army Medical Research and Materiel Command. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.; Dr. Burns is an employee of Premier Consulting and Management Services (PCMS), Atlanta, GA, under contract with the U.S. Army Institute of Surgical Research. NR 23 TC 2 Z9 2 U1 0 U2 0 PU HOSPITAL CLINICAS, UNIV SAO PAULO PI SAO PAULO PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL SN 1807-5932 J9 CLINICS JI Clinics PY 2010 VL 65 IS 11 BP 1189 EP 1195 DI 10.1590/S1807-59322010001100023 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 736JW UT WOS:000288492000023 PM 21243295 ER PT J AU Zhao, Q Swami, A AF Zhao, Qing Swami, Ananthram BE Wyglinski, AM Nekovee, M Hou, YT TI Spectrum sensing and identification SO COGNITIVE RADIO COMMUNICATIONS AND NETWORKS: PRINCIPLES AND PRACTICE LA English DT Article; Book Chapter C1 [Zhao, Qing] Univ Calif Davis, Davis, CA 95616 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Zhao, Q (reprint author), Univ Calif Davis, Davis, CA 95616 USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-087932-1 PY 2010 BP 85 EP 111 DI 10.1016/B978-0-12-374715-0.00004-6 PG 27 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA BEL87 UT WOS:000317277500005 ER PT J AU Siperstein, FR Lisal, M Brennan, JK AF Siperstein, Flor R. Lisal, Martin Brennan, John K. TI A MOLECULAR SIMULATION STUDY OF ADSORPTION OF NITROGEN AND METHANE IN TITANIUM SILICATE (ETS-4) SO COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS LA English DT Article DE Adsorption isotherms; ETS-4; Grand canonical Monte Carlo; Molecular dynamics; Self diffusion ID FORCE-FIELD; ALKANES; DIFFUSION; CLINOPTILOLITES; TEMPERATURE; SEPARATION; ISOTHERMS; ZEOLITES; CATIONS; SODIUM AB Adsorption isotherms of methane and nitrogen in porous titanium silicate ETS-4 (Engelhard titanium silicate) are calculated using grand canonical Monte Carlo (GCMC) simulations. Self-diffusion coefficients are determined using molecular dynamics (MD) simulations. Properties for pure gases were determined for two of the ideal ETS-4 polymorphs (ABAB-AA and ABAB-AC) dehydrated at different temperatures (423 and 573 K), taking into account only the framework atoms of the structure and ignoring the non-framework cations and water molecules. It was observed that equilibrium properties are slightly dependent on the structure selected for idealized polymorphs. However, it is not sufficient to explain the differences in adsorption capacity observed experimentally, which can only be explained with the combination of two polymorphs. In polymorphs with straight channels, self-diffusion in the direction of the main channel is two orders of magnitude larger than through the small rings that connect the main channels with some small cages. The trends observed in the self-diffusion coefficient with loading confirmed that crossing an eight-membered ring is an activated process. C1 [Lisal, Martin] Acad Sci Czech Republic, Vvi, E Hala Lab Thermodynam, Inst Chem Proc Fundamentals, CR-16502 Prague 6, Suchdol, Czech Republic. [Siperstein, Flor R.] Univ Manchester, Sch Chem Engn & Analyt Sci, Manchester M60 1QD, Lancs, England. [Lisal, Martin] Univ JE Purkyne, Dept Phys, Fac Sci, Usti Nad Labem 40096, Czech Republic. [Brennan, John K.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Lisal, M (reprint author), Acad Sci Czech Republic, Vvi, E Hala Lab Thermodynam, Inst Chem Proc Fundamentals, Rozvojova 135, CR-16502 Prague 6, Suchdol, Czech Republic. EM flor.siperstein@manchester.ac.uk; lisal@icpf.cas.cz; john.k.brennan@us.army.mil RI Lisal, Martin/A-8176-2011 OI Lisal, Martin/0000-0001-8005-7143 FU Marie Curie Open Transfer of Knowledge [MTKD-CT-2005-030040]; Generalitat de Catalunya [BE00334]; Ramon y Cajal Program of the Spanish Ministerio de Educacion y Ciencia; Czech Science Foundation [203/08/0094]; National Research Programme "Information Society" [1ET400720507]; Academy of Sciences of the Czech Republic [KAN400720701]; European Community [033304, COST TD0802]; HERA AMASA SL; DINAMIC Innovation Centre FX Support from the Marie Curie Open Transfer of Knowledge project (MTKD-CT-2005-030040) and a mobility grant from the Generalitat de Catalunya BE00334 are gratefully acknowledged. F. R. Siperstein acknowledges support from the Ramon y Cajal Program of the Spanish Ministerio de Educacion y Ciencia and the hospitality at the E. Hala Laboratory of Thermodynamics during this work, as well as useful discussions with F. Leroy at Universitat Rovira i Virgili in Tarragona, Spain. M. L sal acknowledges the Czech Science Foundation (Grant No. 203/08/0094), by the National Research Programme "Information Society" (Project No. 1ET400720507), by the Grant Programme of the Academy of Sciences of the Czech Republic "Nanotechnology for the Society" (Project No. KAN400720701), and by the European Community under the 6th Framework Programme (Project MULTIPRO No. 033304) and under the 7th Framework Programme (Project COST TD0802). This project was partially funded by HERA AMASA SL and DINAMIC Innovation Centre. NR 34 TC 3 Z9 3 U1 2 U2 21 PU INST ORGANIC CHEM AND BIOCHEM PI PRAGUE 6 PA ACAD SCI CZECH REPUBLIC, FLEMINGOVO NAM 2, PRAGUE 6 166 10, CZECH REPUBLIC SN 0010-0765 J9 COLLECT CZECH CHEM C JI Collect. Czech. Chem. Commun. PY 2010 VL 75 IS 2 BP 145 EP 164 DI 10.1135/cccc2009102 PG 20 WC Chemistry, Multidisciplinary SC Chemistry GA 589DM UT WOS:000277125800001 ER PT J AU Strauss, J Kadilak, A Cronin, C Mello, CM Camesano, TA AF Strauss, Joshua Kadilak, Andrea Cronin, Christine Mello, Charlene M. Camesano, Terri A. TI Binding, inactivation, and adhesion forces between antimicrobial peptide cecropin P1 and pathogenic E. coli SO COLLOIDS AND SURFACES B-BIOINTERFACES LA English DT Article DE Bacterial adhesion; Atomic force microscopy; Antimicrobial peptide; Quartz crystal microbalance; Lipopolysaccharide; Biopolymer; Adhesion ID QUARTZ-CRYSTAL MICROBALANCE; SELF-ASSEMBLED MONOLAYERS; ESCHERICHIA-COLI; PHOSPHOLIPID-MEMBRANES; LIPID-BILAYERS; O-ANTIGEN; PSEUDOMONAS-AERUGINOSA; CHAIN-LENGTH; L-CYSTEINE; SURFACES AB The antimicrobial peptide cecropin P1 (CP1) exhibits broad spectrum activity against planktonic bacteria, including Escherichia coli (E. colt) However, its activity when attached to a substrate has not been thoroughly studied We immobilized CP1 to gold or silicon nitride, and studied how the method of attachment of peptide to the surface affected peptide interaction with and killing of the bacteria Using the quartz crystal microbalance with dissipation monitoring (QCM-D), we characterized non-specific binding between CP1 to silicon nitride and gold, and covalent binding of cysteine-terminated CP1 (CP1-cys) to gold The density of CP1-cys adsorbed on gold was more than the density of CP1 on silicon nitride. and activity against E colt also depended on the method of attachment used to anchor the peptide to the surface Twelve E colt strains with known lipopolysaccharide (LPS) structures were studied Bacterial adhesion with CP1 was strongest for E coli with long O-antigens, as determined by atomic force microscopy (AFM) This may be caused by CP1 interacting with the hydrophilic part of the LPS, while control bacteria or those with short O-antigens had their hydrophobic lipid A region more exposed Killing of E col, due to contact with CP1 was dependent on the method by which the peptide was immobilized Four out of 12 E colt strains were killed when contacted with CP1-cys bound to gold via a thiol bond, while all 12 strains could be killed when in contact with CP1 on silicon nitride In summary, both QCM-D adsorption experiments and adhesion forces measured by AFM showed a relationship between bacteria LPS length and binding or interaction with the antimicrobial peptide, but killing of E colt by the peptide was most strongly dependent on how the peptide was attached to the surface (C) 2009 Elsevier B V All rights reserved C1 [Strauss, Joshua; Kadilak, Andrea; Cronin, Christine; Camesano, Terri A.] Gateway Pk Worcester Polytech Inst, Life Sci & Bioengn Ctr, Dept Chem Engn, Worcester, MA 01609 USA. [Mello, Charlene M.] USA, Biosci & Technol Team, NSRDEC, Natick, MA 01760 USA. [Mello, Charlene M.] Univ Massachusetts Dartmouth, Dept Chem & Biochem, Dartmouth, MA 02743 USA. RP Camesano, TA (reprint author), Gateway Pk Worcester Polytech Inst, Life Sci & Bioengn Ctr, Dept Chem Engn, 100 Inst Rd, Worcester, MA 01609 USA. FU National Science Foundation [BES0238627, EEC0452809] FX This work was supported in part by the National Science Foundation, through grants BES0238627 and EEC0452809. NR 75 TC 37 Z9 38 U1 3 U2 44 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-7765 EI 1873-4367 J9 COLLOID SURFACE B JI Colloid Surf. B-Biointerfaces PD JAN 1 PY 2010 VL 75 IS 1 BP 156 EP 164 DI 10.1016/j.colsurfb.2009.08.026 PG 9 WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials SC Biophysics; Chemistry; Materials Science GA 609YR UT WOS:000278695300020 PM 19734022 ER PT J AU Busby, RR Gebhart, DL Torbert, HA Dawson, JO Bollero, GA Potter, KN Curtin, DR AF Busby, R. R. Gebhart, D. L. Torbert, H. A. Dawson, J. O. Bollero, G. A. Potter, K. N. Curtin, D. R. TI Effects of a New Waste-Processing By-product on Soil and Vegetation at Fort Campbell, Tennessee SO COMMUNICATIONS IN SOIL SCIENCE AND PLANT ANALYSIS LA English DT Article DE Heavy metals; municipal waste; nutrient immobilization; plant establishment; soil restoration ID ANDROPOGON-GERARDII; PANICUM-VIRGATUM; RESPONSES; SWITCHGRASS; RECLAMATION; SUCCESSION AB A garbage-processing technology has been developed that sterilizes and separates inorganic and organic components of municipal solid waste. A study was initiated to evaluate the uncomposted organic by-product of this process as a soil amendment for establishing native prairie grasses on disturbed Army training lands. The waste was incorporated into a silt loam soil at Fort Campbell Military Reservation in the central United States. The waste material was applied at rates of 0, 4.5, 9, 18, and 36 Mg ha(-1) and seeded with native prairie grasses to assess its effects on vegetation for two growing seasons, with an additional unseeded control treatment for comparison to natural recovery. Treatments receiving the highest rate of application had significantly more native grass basal cover and percent composition than the controls. Plant phosphorus accumulation increased significantly with increasing pulp application. Soil phosphorus and lead concentrations increased in the top 10 cm of the highest application rates where pulp was mixed in the soil. Because minimal environmental effects were detected and the pulp improved perennial grass establishment and nutrition at the 36 Mg ha(-1) rate, land application should be considered a viable and beneficial alternative to current waste-management practices. C1 [Busby, R. R.; Gebhart, D. L.; Curtin, D. R.] USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. [Torbert, H. A.] ARS, USDA, Natl Soil Dynam Lab, Auburn, AL USA. [Dawson, J. O.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Bollero, G. A.] Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA. [Potter, K. N.] ARS, USDA, Grassland Soil & Water Res Lab, Temple, TX USA. RP Busby, RR (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM ryan.busby@us.army.mil FU U.S. Army Office of the Directorate of Environmental Programs (DAIM); U.S. Army Forces Command; Congressional Plus Up FX We thank Beth Boren and Steve Taylor of the Fort Campbell Environmental Division for their assistance in planning and executing the study; Jerry Carrington, Marlon Siegford, and Dr. Stephen Prior of the USDA-ARS National Soil Dynamics Lab for their expertise in data collection; and Pat Kemme of the U. S. Army Engineer Research and Development Center, Construction Engineering Research Laboratory for her assistance in performing the initial sampling and analysis of the fluff. This study was funded by the U.S. Army Office of the Directorate of Environmental Programs (DAIM), Assistant Chief of Staff (Installation Management); U.S. Army Forces Command; and Congressional Plus Up. NR 34 TC 0 Z9 0 U1 1 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0010-3624 J9 COMMUN SOIL SCI PLAN JI Commun. Soil Sci. Plant Anal. PY 2010 VL 41 IS 3 BP 250 EP 266 DI 10.1080/00103620903460773 PG 17 WC Agronomy; Plant Sciences; Chemistry, Analytical; Soil Science SC Agriculture; Plant Sciences; Chemistry GA 552JR UT WOS:000274286600003 ER PT S AU Grossman, GD Ratajczak, RE Farr, MD Wagner, CM Petty, JT AF Grossman, Gary D. Ratajczak, Robert E., Jr. Farr, Mark D. Wagner, C. Michael Petty, J. Todd BE Gido, KB Jackson, DA TI Why There Are Fewer Fish Upstream SO COMMUNITY ECOLOGY OF STREAM FISHES: CONCEPTS, APPROACHES, AND TECHNIQUES SE American Fisheries Society Symposium LA English DT Proceedings Paper CT Symposium on Community Ecology of Stream Fishes: Concepts, Approaches, and Techniques CY AUG 19-20, 2008 CL Ottawa, CANADA ID SOUTHERN APPALACHIAN STREAM; MICROHABITAT USE; MOTTLED SCULPIN; FLOW REGIME; ASSEMBLAGE; DIVERSITY; PATTERNS; BIODIVERSITY; ORGANIZATION; RIVERS AB Studies demonstrating the mechanisms regulating biodiversity are uncommon. Streams and rivers worldwide display a longitudinal gradient in fish biodiversity, and most prior research has used correlative evidence to infer that higher downstream diversity is produced by factors facilitating greater niche separation. We combine 20 years of fish abundance samples from a representative southern Appalachian stream with critical swimming velocity experiments to provide direct evidence that a shifting hydrodynamic barrier affects this gradient in Coweeta Creek. We observed increased diversity in multiple sites, produced by species immigrating upstream during periodic droughts (1985-1988, 1999-2002) and a highly significant positive relationship (r(2) = 0.77) between drought (Palmer index) and Shannon-Weiner diversity Resident fish generally had smaller standard lengths during drought periods. Critical velocity measurements showed that residents could tolerate faster water velocities than drought immigrants and that upstream velocities in nondrought years were faster than those in some downstream sites. These data support the hypothesis that local fish diversity in this system is limited by the ability of drought immigrants to pass an upstream hydrodynamic barrier. Alternative hypotheses such as temperature differences between sites, increased capture efficiency during droughts, and increased productivity during droughts were not supported by the data. The relationship between drought and diversity in this system is counterintuitive because drought should reduce resource availability and produce lower rather than higher diversity. These results highlight the important relationship between natural flow variation and maintenance of local diversity and demonstrate the need for long-term ecological data. C1 [Grossman, Gary D.; Ratajczak, Robert E., Jr.] Univ Georgia, DB Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. [Farr, Mark D.] US Army, Engineer Res Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Wagner, C. Michael] Michigan State Univ, Dept Fisheries & Wildlife, E Lansing, MI 48824 USA. [Petty, J. Todd] West Virginia Univ, Div Forestry & Nat Resources, Morgantown, WV 26506 USA. RP Grossman, GD (reprint author), Univ Georgia, DB Warnell Sch Forestry & Nat Resources, Athens, GA 30602 USA. EM grossman@uga.edu FU USDA Forest Service McIntire-Stennis program [GEO-0035-MS, GEO-0042-MS, GEO-0047-MS, GEO-0086-MS, GEO-00114-MS, GEO-00144-MS]; National Science Foundation [BSR-9011661, DEB-9632854, DEB-2018001]; Daniel B. Warnell School of Forestry and Natural Resources FX We would like to thank the many staff and students who worked in the senior author's laboratory over the past 17 years, especially P. Rincon, J. Little, A. Thompson, K. McDaniel, and C. Gibson. We owe a debt of gratitude to our families for their material and moral support. Long-term access to the site, hydrological data, and logistical support were provided by J. Vose, and the staff of the USDA Forest Service Coweeta Hydrologic Laboratory Finally, we are indebted to the employees of Jittery Joe's for their stimulating help. This research was funded via long-term support from the USDA Forest Service McIntire-Stennis program (grants GEO-0035-MS, GEO-0042-MS, GEO-0047-MS and GEO-0086-MS, GEO-00114-MS, and GEO-00144-MS) and the National Science Foundation (BSR-9011661, DEB-9632854, DEB-2018001). Additional support was provided by the Daniel B. Warnell School of Forestry and Natural Resources. We are grateful for the suggestions and comments of Shannon Crow, John Drake, Nathaniel Hitt, Daniel McGarvey, Gary Sundin, Wayne Wurtsbaugh, and two anonymous referees. NR 53 TC 20 Z9 21 U1 0 U2 2 PU AMER FISHERIES SOC PI BETHESDA PA 5410 GROSVENOR LANE, STE 110, BETHESDA, MD 20814-2199 USA SN 0892-2284 BN 978-1-934874-14-1 J9 AM FISH S S JI Am. Fish. Soc. Symp. PY 2010 VL 73 BP 63 EP 81 PG 19 WC Fisheries; Marine & Freshwater Biology SC Fisheries; Marine & Freshwater Biology GA BG9QO UT WOS:000393626300004 ER PT J AU Gawandi, A Carlsson, LA Bogetti, TA Gillespie, JW AF Gawandi, Anis Carlsson, Leif A. Bogetti, Travis A. Gillespie, John W., Jr. TI Mechanics of discontinuous ceramic tile core sandwich structure: Influence of thermal and interlaminar stresses SO COMPOSITE STRUCTURES LA English DT Article DE Sandwich; Thermal; Stress; Failure; Interlaminar; Interface ID VARIATIONAL APPROACH; CONSTITUTIVE RELATIONS; COMPOSITE-MATERIALS; MATRIX CRACKING; DEGRADATION AB The stress states in a discontinuous ceramic tile core sandwich structure due to mechanical and thermal loading are investigated. The influence of coefficient of thermal expansion (CTE) mismatch between the tile and face sheet layer on the in-plane and interlaminar stresses in the sandwich structure is evaluated. The factors affecting the interlaminar stresses in the structure are of particular interest. The influence of an adhesive layer between the face sheet and core on the effective properties of the sandwich is also discussed. A study is performed to evaluate tailoring of the adhesive properties to reduce interfaminar stresses for increased durability. A parametric study is performed to study how various geometric parameters such as tile and adhesive layer thickness affect the effective properties (e.g. axial modulus and CTE). Failure of the discontinuous core sandwich structure under in-plane tension loading is analyzed. It is observed that thermal property mismatch in the structure can significantly reduce the failure loads for the tile layer. Finally, failure of the sandwich corresponding to various failure modes is discussed. (C) 2009 Elsevier Ltd. All rights reserved. C1 [Gawandi, Anis; Gillespie, John W., Jr.] Univ Delaware, Ctr Composite Mat, Newark, DE 19711 USA. [Carlsson, Leif A.] Florida Atlantic Univ, Dept Mech Engn, Boca Raton, FL 33431 USA. [Bogetti, Travis A.] USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Gawandi, A (reprint author), Univ Delaware, Ctr Composite Mat, Newark, DE 19711 USA. EM Gawandi@udel.edu NR 20 TC 7 Z9 7 U1 0 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0263-8223 J9 COMPOS STRUCT JI Compos. Struct. PD JAN PY 2010 VL 92 IS 1 BP 164 EP 172 DI 10.1016/j.compstruct.2009.07.022 PG 9 WC Materials Science, Composites SC Materials Science GA 516SO UT WOS:000271563100018 ER PT J AU Steggall-Murphy, C Simacek, P Advani, SG Yarlagadda, S Walsh, S AF Steggall-Murphy, Claire Simacek, Pavel Advani, Suresh G. Yarlagadda, Shridhar Walsh, Shawn TI A model for thermoplastic melt impregnation of fiber bundles during consolidation of powder-impregnated continuous fiber composites SO COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING LA English DT Article; Proceedings Paper CT 9th International Conference on Flow Processes in Composite Materials CY JUL 08-10, 2008 CL Montreal, CANADA DE Polymer matrix composites (PMC's); Thermoplastic resin; Analytical modeling; Compression molding ID COMMINGLED YARNS; PREPREG AB Continuous fiber thermoplastic matrix composites were fabricated using a novel powder-impregnation process that combined vacuum assisted resin transfer molding (VARTM) with compression molding. The resulting composite has an average fiber volume fraction of 65%. A model has been developed for the consolidation phase to predict the void fraction of the resulting composite. This model takes into account the fabric unit cell dimensions and material properties and assumes that tow permeability remains constant. The model is compared to experimental values for void fraction for samples prepared using a range of consolidation pressures and dwell times. (C) 2009 Published by Elsevier Ltd. C1 [Steggall-Murphy, Claire; Simacek, Pavel; Advani, Suresh G.] Univ Delaware, Ctr Composite Mat, Dept Mech Engn, Newark, DE 19716 USA. [Yarlagadda, Shridhar] Univ Delaware, Ctr Composite Mat, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Walsh, Shawn] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Advani, SG (reprint author), Univ Delaware, Ctr Composite Mat, Dept Mech Engn, Newark, DE 19716 USA. EM advani@udel.edu NR 28 TC 10 Z9 13 U1 2 U2 40 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1359-835X J9 COMPOS PART A-APPL S JI Compos. Pt. A-Appl. Sci. Manuf. PD JAN PY 2010 VL 41 IS 1 SI SI BP 93 EP 100 DI 10.1016/j.compositesa.2009.09.026 PG 8 WC Engineering, Manufacturing; Materials Science, Composites SC Engineering; Materials Science GA 543BV UT WOS:000273545800012 ER PT J AU Barth, H Stiles, BG AF Barth, Holger Stiles, Bradley G. BE Mander, L Liu, HW TI Protein Toxins from Bacteria SO COMPREHENSIVE NATURAL PRODUCTS II: CHEMISTRY AND BIOLOGY, VOL 5: AMINO ACIDS, PEPTIDES AND PROTEINS LA English DT Article; Book Chapter ID STAPHYLOCOCCAL-ENTEROTOXIN-B; BOTULINUM C2 TOXIN; SHOCK-SYNDROME TOXIN-1; T-CELL-RECEPTOR; MHC CLASS-II; MAJOR HISTOCOMPATIBILITY COMPLEX; PERFRINGENS IOTA-TOXIN; TUMOR-NECROSIS-FACTOR; CLOSTRIDIUM-DIFFICILE INFECTION; HUMAN PERIPHERAL-BLOOD C1 [Barth, Holger] Univ Ulm, Med Ctr, D-89069 Ulm, Germany. [Stiles, Bradley G.] Wilson Coll, Chambersburg, PA USA. [Stiles, Bradley G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA. RP Barth, H (reprint author), Univ Ulm, Med Ctr, D-89069 Ulm, Germany. NR 202 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-045382-8 PY 2010 BP 149 EP 173 PG 25 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA BA4ZT UT WOS:000336460200006 ER PT B AU Cusatis, G Schauffert, EA Pelessone, D O'Daniel, JL Marangi, P Stacchini, M Savoia, M AF Cusatis, G. Schauffert, E. A. Pelessone, D. O'Daniel, J. L. Marangi, P. Stacchini, M. Savoia, M. BE Bicanic, N DeBorst, R Mang, H Meschke, G TI Lattice Discrete Particle Model for Fiber reinforced concrete (LDPM-F) with application to the numerical simulation of armoring systems SO COMPUTATIONAL MODELLING OF CONCRETE STRUCTURES LA English DT Proceedings Paper CT EURO-C Conference CY MAR 15-18, 2010 CL Schladming, AUSTRIA SP EURO C ID SPRING NETWORKS; FRACTURE; COMPOSITES; COMPRESSION; TENSION; DAMAGE AB In this paper, the Lattice Discrete Particle Model (LDPM) is extended to include the effect of dispersed fibers with the objective of simulating the behavior of fiber reinforced concrete for armoring system applications. Within the LDPM framework, the effect of dispersed fibers is taken into account through the following procedure. 1) Fibers are randomly placed in the volume of interest according to the given fiber volume ratio and fiber geometry. 2) The number and orientation of fibers crossing each facet are computed along with the fiber embedment length on each side of the facet. 3) At the facet level, fibers and plain concrete are assumed to be coupled in parallel. 4) The contribution of each fiber to the facet response is formulated on the basis of a micromechanical model of fiber-matrix interaction. The developed model, named LDPM-F, is validated by carrying out numerical simulations of direct tension and three-point bending tests on fiber reinforced concrete mixes characterized by various fiber volume fractions. Finally, LDPM-F is applied to the analysis of the penetration resistance of fiber reinforced slabs. C1 [Cusatis, G.; Schauffert, E. A.] Rensselaer Polytech Inst, Troy, NY 12181 USA. [Pelessone, D.] ES3, Solana Beach, CA USA. [O'Daniel, J. L.] Engn Res & Dev Ctr, Vicksburg, MS USA. [Marangi, P.; Stacchini, M.; Savoia, M.] Univ Bologna, Bologna, Italy. RP Cusatis, G (reprint author), Rensselaer Polytech Inst, Troy, NY 12181 USA. FU US Army Engineer Research and Development Center (ERDC); DTRA [HDTRA1-09-1-0029] FX This effort was sponsored in part by the US Army Engineer Research and Development Center (ERDC). Permission to publish was granted by the Director, Geotechnical and Structures Laboratory, ERDC. The work of the first two authors was also supported under DTRA grant HDTRA1-09-1-0029 to Rensselaer Polytechnic Institute. This financial support is gratefully acknowledged. NR 22 TC 2 Z9 2 U1 0 U2 0 PU CRC PRESS-TAYLOR & FRANCIS GROUP PI BOCA RATON PA 6000 BROKEN SOUND PARKWAY NW, STE 300, BOCA RATON, FL 33487-2742 USA BN 978-0-203-84833-3; 978-0-415-58479-1 PY 2010 BP 291 EP 300 PG 10 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA BG7YM UT WOS:000392025000031 ER PT S AU Cardello, AV Jaeger, SR AF Cardello, A. V. Jaeger, S. R. BE Jaeger, SR MacFie, H TI Hedonic measurement for product development: new methods for direct and indirect scaling SO CONSUMER-DRIVEN INNOVATION IN FOOD AND PERSONAL CARE PRODUCTS SE Woodhead Publishing in Food Science Technology and Nutrition LA English DT Article; Book Chapter DE scaling methodology; labeled affective magnitude scale (LAM); best-worst scaling (BWS) ID ACROSS-GROUP COMPARISONS; LONG-TERM ACCEPTABILITY; LABELED MAGNITUDE SCALE; SENSORY EVALUATION; PROBABILISTIC MODELS; FOOD ACCEPTABILITY; PERCEIVED SATIETY; GENETIC-VARIATION; TASTE PERCEPTION; CATEGORY SCALES AB Hedonic measures, e. g. judgments of liking/disliking, pleasure/displeasure, preference, etc., obtained in response to products are used to make critical decisions throughout the R&D cycle. Although the history of hedonic testing is long, new methods of measurement continue to evolve in the literature. This continual development is driven by the importance of the hedonic construct to sensory scientists working in industry and to scholars interested in the quantification of human sensory, attitudinal and emotional responses. In this chapter we examine two recent developments in hedonic scaling: the method of best-worst scaling and the method of labeled affective magnitude scaling. These two techniques represent examples of indirect and direct scaling, respectively. In order to fully understand both the theoretical and practical differences between these methods, the chapter begins with an historical account of indirect and direct scaling methods in psychophysics. Next, the methods and techniques of best-worst and labeled affective magnitude scaling are introduced in detail, focusing on practical aspects. The chapter concludes with a comparison among methods of hedonic scaling and we offer recommendations regarding the most effective and efficient assessment of hedonic differences among test stimuli, from a methods perspective. C1 [Cardello, A. V.] USA, Natick Soldier R D&E Ctr, Natick, MA 01760 USA. [Jaeger, S. R.] New Zealand Inst Plant & Food Res Ltd, Auckland 1025, New Zealand. RP Cardello, AV (reprint author), USA, Natick Soldier R D&E Ctr, Natick, MA 01760 USA. EM Armand.Cardello@us.army.mil; sara.jaeger@plantandfood.co.nz RI Jaeger, Sara/R-2648-2016; OI Jaeger, Sara/0000-0002-4960-5233 NR 163 TC 1 Z9 1 U1 1 U2 7 PU WOODHEAD PUBL LTD PI CAMBRIDGE PA ABINGTON HALL ABINGTON, CAMBRIDGE CB1 6AH, CAMBS, ENGLAND SN 2042-8049 BN 978-1-84569-567-5 J9 WOODHEAD PUBL FOOD S JI Woodhead Publ. Food Sci. Technol. Nutr. PY 2010 IS 195 BP 135 EP 174 DI 10.1533/9781845699970.2.135 D2 10.1533/9781845699970 PG 40 WC Food Science & Technology SC Food Science & Technology GA BVB25 UT WOS:000290950300008 ER PT S AU Ritchie, EC AF Ritchie, Elspeth Cameron BE Wiederhold, BK TI Psychological Issues of War: Information Gained from US Army Surveillance and Research and Strategies for Mitigation SO COPING WITH POSTTRAUMATIC STRESS DISORDER IN RETURNING TROOPS: WOUNDS OF WAR II SE Nato Science for Peace and Security Series E-Human and Societal Dynamics LA English DT Proceedings Paper CT NATO Advanced Workshop on Wounds of War - Coping with Posttraumatic Stress Disorder in Returning Troops CY OCT 19-21, 2009 CL Sudkarnten, AUSTRIA SP N Atlantic Treaty Org Sci Peace & Secur Programme Initiat, Austrian Minist Def, Univ Hosp Dubrava, Croatian Minist Hlth & Social Welfare, US Army Med Res & Mat Command, Virtual Real Med Ctr, Interact Media Inst, Virtual Real Med Inst DE Psychological health; US army; suicide; posttraumatic stress disorder; traumatic brain injury ID MENTAL-HEALTH PROBLEMS; IRAQ; AFGHANISTAN AB Eight years of war and repeated deployments have led to both physical and psychological wounds in the United States Army. This paper will discuss both old and new challenges, including suicide, posttraumatic stress disorder (PTSD), traumatic brain injury (TBI) and pain management. While an array of behavioral health services has long been available to address the troubling effects on our Soldiers and Families, these services are clearly strained. These services include Combat and Operational Stress Control, routine behavioral health care, and suicide prevention. Pre-clinical services, such as Chaplains, Military One Source and Army Community Service also offer support. We have multiple other initiatives to provide outreach, education and training, including "Battlemind," Combat and Operational Stress Control, Warrior Adventure Quest and RESPECT-MIL. There continue to be major challenges that will face our service members, their Families and the United States. C1 [Ritchie, Elspeth Cameron] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Ritchie, EC (reprint author), US Army, 5109 Leesburg Pike,Skyline 6,Room 684, Falls Church, VA 22041 USA. EM Elspeth.Ritchie@us.army.mil NR 3 TC 0 Z9 0 U1 0 U2 0 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1879-8268 BN 978-1-60750-571-6; 978-1-60750-570-9 J9 NATO SCI PEACE SEC PY 2010 VL 68 BP 109 EP 114 DI 10.3233/978-1-60750-571-6-109 PG 6 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC1YS UT WOS:000350553400009 ER PT S AU Stetz, MC Ganz, MB Folen, RA AF Stetz, Melba C. Ganz, Michael B. Folen, Raymond A. BE Wiederhold, BK TI Virtual Reality and Biofeedback to Help War Fighters Deal with Stress SO COPING WITH POSTTRAUMATIC STRESS DISORDER IN RETURNING TROOPS: WOUNDS OF WAR II SE Nato Science for Peace and Security Series E-Human and Societal Dynamics LA English DT Proceedings Paper CT NATO Advanced Workshop on Wounds of War - Coping with Posttraumatic Stress Disorder in Returning Troops CY OCT 19-21, 2009 CL Sudkarnten, AUSTRIA SP N Atlantic Treaty Org Sci Peace & Secur Programme Initiat, Austrian Minist Def, Univ Hosp Dubrava, Croatian Minist Hlth & Social Welfare, US Army Med Res & Mat Command, Virtual Real Med Ctr, Interact Media Inst, Virtual Real Med Inst DE Combat Stress; Virtual Reality; Biofeedback; Military AB Many individuals in the world suffer from stress. The United States military is no exception. In fact, many war fighters return from theater with combat stress symptoms. Sadly, they often worry about becoming stigmatized if they seek professional help. Fortunately, the new generation of war fighters seems to be very technologically-driven. Therefore, a new promising and less stigmatized way to reach out to service members could be via VR. The purpose of this article is to briefly discuss combat stress and how the virtual reality, along with biofeedback, may be use to help war fighters. C1 [Stetz, Melba C.; Ganz, Michael B.; Folen, Raymond A.] Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Stetz, MC (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. EM melba.stetz@us.army.mil NR 22 TC 0 Z9 0 U1 0 U2 0 PU IOS PRESS PI AMSTERDAM PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS SN 1879-8268 BN 978-1-60750-571-6; 978-1-60750-570-9 J9 NATO SCI PEACE SEC PY 2010 VL 68 BP 185 EP 192 DI 10.3233/978-1-60750-571-6-185 PG 8 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA BC1YS UT WOS:000350553400016 ER PT J AU Logue, BA Hinkens, DM Baskin, SI Rockwood, GA AF Logue, Brian A. Hinkens, Diane M. Baskin, Steven I. Rockwood, Gary A. TI The Analysis of Cyanide and its Breakdown Products in Biological Samples SO CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY LA English DT Review DE cyanide; thiocyanate; 2-amino-2-thiazoline-4-carboxylic acid (ATCA); chemical warfare agent; exposure; toxicology; analytical methods ID PERFORMANCE LIQUID-CHROMATOGRAPHY; HEADSPACE GAS-CHROMATOGRAPHY; SELECTIVE-MEMBRANE-ELECTRODE; SOLID-PHASE MICROEXTRACTION; METABOLITE 2-AMINOTHIAZOLINE-4-CARBOXYLIC ACID; NITROGEN PHOSPHORUS DETECTION; BLOOD CYANIDE; ION CHROMATOGRAPHY; WHOLE-BLOOD; MASS-SPECTROMETRY AB Cyanide is a toxic chemical that may be introduced into living organisms as a result of natural processes and/or anthropogenic uses (legal or illicit). Exposure to cyanide can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, law-enforcement, military, forensic, research, or veterinary purposes. This review will discuss current bioanalytical techniques used for the verification of cyanide exposure, identify common problems associated with the analysis of cyanide and its biological breakdown products, and briefly address the metabolism and toxicokinetics of cyanide and its breakdown products in biological systems. C1 [Logue, Brian A.; Hinkens, Diane M.] S Dakota State Univ, Dept Chem & Biochem, Brookings, SD 57007 USA. [Baskin, Steven I.; Rockwood, Gary A.] USA, Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA. RP Logue, BA (reprint author), S Dakota State Univ, Dept Chem & Biochem, POB 2202, Brookings, SD 57007 USA. EM brian.logue@sdstate.edu FU National Institutes of Health Office of the Director; National Institute of Allergy and Infectious Diseases; Department of Defense [Y1-A1-6176-03/A120-B.P2008-01] FX The authors gratefully acknowledge funding support from the National Institutes of Health Office of the Director, the National Institute of Allergy and Infectious Diseases, and the Department of Defense, Grant Number Y1-A1-6176-03/A120-B.P2008-01. The authors would also like to acknowledge the work of Mitch Perrizo of South Dakota State University, whose organization of the many references was invaluable. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the National Institutes of Health, the National Institute of Allergy and Infectious Diseases, the Department of the Army, or the Department of Defense. NR 266 TC 35 Z9 36 U1 4 U2 48 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1040-8347 J9 CRIT REV ANAL CHEM JI Crit. Rev. Anal. Chem. PY 2010 VL 40 IS 2 BP 122 EP 147 AR PII 921990964 DI 10.1080/10408340903535315 PG 26 WC Chemistry, Analytical SC Chemistry GA 594FB UT WOS:000277518600005 ER PT J AU Aoki, KR Smith, LA Atassi, MZ AF Aoki, K. Roger Smith, Leonard A. Atassi, M. Zouhair TI Mode of Action of Botulinum Neurotoxins: Current Vaccination Strategies and Molecular Immune Recognition SO CRITICAL REVIEWS IN IMMUNOLOGY LA English DT Article DE Antigenic sites; antibodies; botulinum neurotoxin; cervical dystonia; epitopes; immunoresistance; mechanism of action; subunit; synthetic peptides; vaccines ID SPERM-WHALE MYOGLOBIN; CHAIN FRAGMENT-C; TOXIN TYPE-A; ANTIBODY-BINDING REGIONS; COMPREHENSIVE SYNTHETIC APPROACH; NUCLEOTIDE-SEQUENCE ANALYSIS; CERVICAL DYSTONIA PATIENTS; N-DOMAIN RESIDUES-449-859; YEAST PICHIA-PASTORIS; AMINO-ACID-SEQUENCE AB The action of a botulinum neurotoxin (BoNT) commences by binding at the nerve terminal via its H- (heavy) chain to a cell-surface receptor, which consists of a ganglioside and a cell-surface protein. Binding enables the L-chain, a Zn(2+)-dependent endopeptidase, to be internalized and act intracellularly, cleaving one or more SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) proteins required for vesicle docking and fusion, which results in reduced neurotransmitter release. Sprouts emerge at motor-nerve terminals that reestablish synaptic contact and lead to restoration of exocytosis. As the terminals recover, sprouts retreat and synaptic function is fully re-established. Neutralizing antibodies (Abs) induced by vaccination can prevent the neuronal changes produced by BoNT. Until recently, vaccines against BoNT have been based on toxins inactivated by treatment with formaldehyde (toxoids) and contain either one (monovalent) or five (pentavalent) toxoids, but formalin-based toxoids have many undesirable side effects. Availability of the gene sequences of BoNT serotypes enabled design of recombinant subunit vaccines that have included the C-terminal domain of the H chain (H(C)), its subdomains (H(C)-N and H(C)-C), the L- (catalytic) chain, and the L-chain expressed with the translocation domain (LCH(N)). Of these, the H(C) displays the highest protective ability. Recent vaccines have used whole toxins inactivated by three key mutations at the enzyme active site, which have been found to be very effective in mice against the correlated toxin. Immune responses to BoNTs A and B epitopes are under the host's MHC (major histocompatibility complex) control. Anti-BoNT/A blocking Abs bind at sites that coincide or overlap with those that bind synaptosomes and to BoNT/B at sites that overlap with synaptotagmin-II and ganglioside-binding sites. Therefore, locations occupied by blocking Abs preclude the respective toxin from binding to its receptor and thus from binding to cell surface. Information on BoNT epitopes for blocking Abs, sites for binding to cell surface receptors, and T-cell epitopes that provide help to B cells making blocking Abs afford a prospect for rational design of stable synthetic vaccines. These constructs should be clinically useful for epitope-selective modulation of Ab responses to restore effective BoNT treatment in immunoresistant patients. C1 [Atassi, M. Zouhair] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA. [Atassi, M. Zouhair] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA. [Smith, Leonard A.] US Army Med Res & Mat Command, Frederick, MD USA. [Aoki, K. Roger] Allergan Pharmaceut Inc, Irvine, CA USA. RP Atassi, MZ (reprint author), Baylor Coll Med, Dept Biochem & Mol Biol, 1 Baylor Plaza, Houston, TX 77030 USA. EM matassi@bcm.tmc.edu FU Allergan; Joint Science and Technology Office for Chemical-Biological Defense; Welch Foundation, FX This work was supported by grants from Allergan and from the Joint Science and Technology Office for Chemical-Biological Defense, and from the Welch Foundation's award to M. Z. Atassi of the Robert A. Welch Chair of Chemistry. NR 155 TC 34 Z9 35 U1 1 U2 15 PU BEGELL HOUSE INC PI REDDING PA 50 CROSS HIGHWAY, REDDING, CT 06896 USA SN 1040-8401 J9 CRIT REV IMMUNOL JI Crit. Rev. Immunol. PY 2010 VL 30 IS 2 BP 167 EP 187 PG 21 WC Immunology SC Immunology GA 590AZ UT WOS:000277197000005 PM 20370628 ER PT J AU Jacobi, HW Domine, F Simpson, WR Douglas, TA Sturm, M AF Jacobi, H. -W. Domine, F. Simpson, W. R. Douglas, T. A. Sturm, M. TI Simulation of the specific surface area of snow using a one-dimensional physical snowpack model: implementation and evaluation for subarctic snow in Alaska SO CRYOSPHERE LA English DT Article ID NUMERICAL-MODEL; SPECTRAL ALBEDO; SNOATACK MODEL; SEASONAL SNOW; ALPINE SITE; COVER; ICE; ADSORPTION; TEMPERATURE; EVOLUTION AB The specific surface area (SSA) of the snow constitutes a powerful parameter to quantify the exchange of matter and energy between the snow and the atmosphere. However, currently no snow physics model can simulate the SSA. Therefore, two different types of empirical parameterizations of the specific surface area (SSA) of snow are implemented into the existing one-dimensional snow physics model CROCUS. The parameterizations are either based on diagnostic equations relating the SSA to parameters like snow type and density or on prognostic equations that describe the change of SSA depending on snow age, snowpack temperature, and the temperature gradient within the snowpack. Simulations with the upgraded CROCUS model were performed for a subarctic snowpack, for which an extensive data set including SSA measurements is available at Fairbanks, Alaska for the winter season 2003/2004. While a reasonable agreement between simulated and observed SSA values is obtained using both parameterizations, the model tends to overestimate the SSA. This overestimation is more pronounced using the diagnostic equations compared to the results of the prognostic equations. Parts of the SSA deviations using both parameterizations can be attributed to differences between simulated and observed snow heights, densities, and temperatures. Therefore, further sensitivity studies regarding the thermal budget of the snowpack were performed. They revealed that reducing the thermal conductivity of the snow or increasing the turbulent fluxes at the snow surfaces leads to a slight improvement of the simulated thermal budget of the snowpack compared to the observations. However, their impact on further simulated parameters like snow height and SSA remains small. Including additional physical processes in the snow model may have the potential to advance the simulations of the thermal budget of the snowpack and, thus, the SSA simulations. C1 [Jacobi, H. -W.; Domine, F.] Univ Grenoble 1, CNRS, Lab Glaciol & Geophys Environm, F-38402 St Martin Dheres, France. [Simpson, W. R.] Univ Alaska, Inst Geophys, Fairbanks, AK USA. [Simpson, W. R.] Univ Alaska, Dept Chem & Biochem, Fairbanks, AK 99701 USA. [Douglas, T. A.; Sturm, M.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Jacobi, HW (reprint author), Univ Grenoble 1, CNRS, Lab Glaciol & Geophys Environm, F-38402 St Martin Dheres, France. EM jacobi@lgge.obs.ujf-grenoble.fr RI Domine, Florent/E-8699-2011; Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 NR 47 TC 13 Z9 13 U1 0 U2 9 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLEE 1E, GOTTINGEN, 37081, GERMANY SN 1994-0416 J9 CRYOSPHERE JI Cryosphere PY 2010 VL 4 IS 1 BP 35 EP 51 PG 17 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA 576QT UT WOS:000276162200004 ER PT J AU Atkinson, R Bauer, C Blakley, B Brassard, G Buonafalce, A Bury, J Christensen, C Desmedt, Y Gaddy, DW Gillogly, J Hamer, D Hanyok, RJ Hartwig, R Hellman, M Kruh, L Maurer, U Naccache, D Quisquater, JJ Rivest, R Singh, S Winkel, BJ Yung, M AF Atkinson, Russell Bauer, Craig Blakley, Bob Brassard, Gilles Buonafalce, Augusto Bury, Jan Christensen, Chris Desmedt, Yvo Gaddy, David Winfred Gillogly, Jim Hamer, David Hanyok, Robert J. Hartwig, Robert Hellman, Martin Kruh, Lou Maurer, Ueli Naccache, David Quisquater, Jean-Jacques Rivest, Ron Singh, Simon Winkel, Brian J. Yung, Moti TI A Tribute to David Kahn SO CRYPTOLOGIA LA English DT Biographical-Item C1 [Blakley, Bob] Texas A&M Univ, College Stn, TX 77843 USA. [Brassard, Gilles] Univ Montreal, Montreal, PQ H3C 3J7, Canada. [Bury, Jan] Cardinal Stefan Wyszynski Univ, Warsaw, Poland. [Desmedt, Yvo] UCL, London, England. [Maurer, Ueli] ETH, Zurich, Switzerland. [Naccache, David] Ecole Normale Super, F-75231 Paris, France. [Quisquater, Jean-Jacques] UCL, Louvain, Belgium. [Rivest, Ron] MIT, Cambridge, MA 02139 USA. [Winkel, Brian J.] US Mil Acad, West Point, NY USA. [Yung, Moti] Google, Mountain View, CA 94043 USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0161-1194 J9 CRYPTOLOGIA JI Cryptologia PY 2010 VL 34 IS 1 BP 1 EP 11 AR PII 917901545 DI 10.1080/01611190903408001 PG 11 WC Computer Science, Theory & Methods; History & Philosophy Of Science; Mathematics, Applied SC Computer Science; History & Philosophy of Science; Mathematics GA 534LK UT WOS:000272898200001 ER PT J AU Winkel, B AF Winkel, Brian TI David, Calm Down! On Second and More Reflective Thought, Don't! SO CRYPTOLOGIA LA English DT Article DE censorship; David Kahn; editorship; righteous indignation AB We recount our relationship with David Kahn as co-founding editors of Cryptologia-both in specific incidents and broader experiences. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Winkel, B (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM Brian.Winkel@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0161-1194 J9 CRYPTOLOGIA JI Cryptologia PY 2010 VL 34 IS 2 BP 101 EP 103 DI 10.1080/01611191003590763 PG 3 WC Computer Science, Theory & Methods; History & Philosophy Of Science; Mathematics, Applied SC Computer Science; History & Philosophy of Science; Mathematics GA 591YF UT WOS:000277340800001 ER PT J AU Wagner, TD Yang, GY AF Wagner, Timothy D. Yang, Gary Y. TI The Role of Chemotherapy and Radiation in the Treatment of Locally Advanced Non-Small Cell Lung Cancer (NSCLC) SO CURRENT DRUG TARGETS LA English DT Review DE Radiation therapy; pemetrexed; locally advanced non-small cell lung cancer; concurrent chemoradiation ID INTENSITY-MODULATED RADIOTHERAPY; RANDOMIZED PHASE-II; LEUKEMIA GROUP-B; NAIVE PATIENTS; TRIAL; CISPLATIN; CARBOPLATIN; IRRADIATION; THERAPY; CHEMORADIOTHERAPY AB Approximately one out of every three patients with non-small cell lung cancer (NSCLC) has locally advanced disease that is surgically unresectable. If their performance status allow, it is current practice to treat these patients with a combination of chemotherapy and external beam irradiation. There have been several studies supporting the addition of chemotherapy to radiation, particularly when delivered concurrently. There is a debate over which treatment agents and schedules are the most optimal, even with the most proven treatments delivering only modest results, with high rates of local and distant disease failure. Advances in imaging, radiation planning and delivery technology have allowed the potential for improvement of the therapeutic ratio by reducing normal tissue exposure and ensuring for more precise delivery, while new systemic agents show promising activity in NSCLC. Pemetrexed is a pyrrolopyrimidine-based folate anti-metabolite that works by inhibiting a variety of enzymes of thymidylate and purine synthesis, thus leading to cell stasis and death. Similar to other cytotoxic antifolates, pemetrexed has been shown in pre-clinical study to act as an effective radiosensitizer. At present, it is being studied in phase I and II studies when combined with other systemic agents and radiation therapy in the treatment of locally advanced NSCLC, and the results have been promising. It has the advantage of allowing relatively safe delivery of full systemic doses when combined with other agents and radiation therapy, a distinction over combined modality treatments. Its efficacy, particularly in non-squamous NSCLC, in phase I and II studies has lead to investigations in the phase III setting where a more defined role for pemetrexed in locally advanced non-squamous NSCLC will potentially be defined. This review summarizes the use of combined modality treatment in locally advanced NSCLC, outlines recent advances in radiation planning and treatment, and reviews the current data on the use of concurrent chemoradiation regimens featuring pemetrexed. C1 [Wagner, Timothy D.] Brooke Army Med Ctr, Dept Radiol, Radiat Oncol Serv, Ft Sam Houston, TX 78234 USA. [Yang, Gary Y.] Roswell Pk Canc Inst, Dept Radiat Med, Buffalo, NY 14263 USA. RP Wagner, TD (reprint author), Brooke Army Med Ctr, Dept Radiol, Radiat Oncol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM timothy.d.wagner@us.army.mil NR 51 TC 19 Z9 20 U1 1 U2 5 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1389-4501 J9 CURR DRUG TARGETS JI Curr. Drug Targets PD JAN PY 2010 VL 11 IS 1 BP 67 EP 73 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 532KO UT WOS:000272747000009 PM 19839925 ER PT S AU Endy, TP Yoon, IK Mammen, MP AF Endy, Timothy P. Yoon, In-Kyu Mammen, Mammen P. BE Rothman, AL TI Prospective Cohort Studies of Dengue Viral Transmission and Severity of Disease SO DENGUE VIRUS SE Current Topics in Microbiology and Immunology LA English DT Review; Book Chapter ID PRIMARY-SCHOOL CHILDREN; KAMPHAENG-PHET; SHOCK SYNDROME; RISK-FACTORS; THAILAND; VIRUS; INFECTION; EPIDEMIOLOGY; CIRCULATION; INDONESIA AB As the four serotypes of dengue virus (DENV) systematically spread throughout the tropical and subtropical regions globally, dengue is increasingly contributing to the overall morbidity and mortality sustained by populations and thereby challenging the health infrastructures of most endemic countries. DENV-human host-mosquito vector interactions are complex and cause in humans either asymptomatic or subclinical DENV infection, mild to severe dengue fever (DF), severe dengue hemorrhagic fever (DHF), or dengue shock syndrome (DSS). Over the past decade, we have seen an increase in research funding and public health efforts to offset the effects of this pandemic. Though multiple vaccine development efforts are underway, the need remains to further characterize the determinants of varying severities of clinical outcomes. Several long-term prospective studies on DENV transmission and dengue severity have sought to define the epidemiology and pathogenesis of this disease. Yet, more studies are required to quantify the disease burden on different populations, explore the impact of DENV serotype-specific transmission on host-responses and dengue severity and measure the economic impact of dengue on a population. In this section, we will review the critical past and recent findings of dengue prospective studies on our understanding of the disease and the potential role of future prospective cohort studies in advancing issues required for vaccine field evaluations. C1 [Endy, Timothy P.] Upstate Med Univ, SUNY Syracuse, Dept Med, Div Infect Dis, Syracuse, NY 13210 USA. [Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. [Mammen, Mammen P.] US Army Med Mat Dev Act, Ft Detrick, MD 21702 USA. RP Endy, TP (reprint author), Upstate Med Univ, SUNY Syracuse, Dept Med, Div Infect Dis, 725 Irving Ave,Suite 304, Syracuse, NY 13210 USA. EM endyt@upstate.edu; InKyu.Yoon@afrims.org; mammen.mammen@us.army.mil NR 14 TC 36 Z9 36 U1 1 U2 11 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 0070-217X BN 978-3-642-02214-2 J9 CURR TOP MICROBIOL JI Curr.Top.Microbiol.Immunol. PY 2010 VL 338 BP 1 EP 13 DI 10.1007/978-3-642-02215-9_1 D2 10.1007/978-3-642-02215-9 PG 13 WC Immunology; Microbiology SC Immunology; Microbiology GA BMW93 UT WOS:000273776100001 PM 19802574 ER PT J AU Henning, MJS Firoz, BF AF Henning, Major J. Scott Firoz, Bahar F. TI Contribution of Dermatologic Surgery in War SO DERMATOLOGIC SURGERY LA English DT Article AB BACKGROUND Despite the large contribution by dermatology to military readiness, there have been no published reports regarding dermatologic surgery or skin cancer in the combat environment. OBJECTIVE To outline the contribution of dermatologic surgery, including skin cancer and benign tumors, to deployed service men and women in Operation Iraqi Freedom. METHODS A retrospective chart review was performed of all dermatology visits at the 86th Combat Support Hospital, Ibn Sina, Iraq, between January 15, 2008 and July 15, 2008. RESULTS Two thousand six hundred ninety-six patients were seen in the combat dermatology clinic during the 6-month period reviewed; 8% (205/2,696) of the total visits were for skin cancer, and another 129 patients were treated for actinic keratosis. The specific diagnoses were basal cell carcinoma (n=70), in situ and invasive squamous cell carcinoma (n=68), mycosis fungoides (n=1), bowenoid papulosis (n=1), and in situ and invasive melanoma (n=9). Benign lesions and tumors accounted for 14% (357/2,696) of total patient visits. Three hundred seven surgeries were performed during the 6-month period (178 skin cancers and 129 benign lesions), and 20 patients were referred for Mohs micrographic surgery. The surgical complications included five postoperative wound infections (1 methicillin-resistant Staphylococcus aureus), one wound dehiscence, and seven allergic contact dermatitis. CONCLUSIONS To the authors' knowledge, this is the first publication regarding skin cancer and dermatologic surgery in the combat setting. This report outlines the important contribution of dermatologic surgery in the combat environment. The authors have indicated no significant interest with commercial supporters. C1 [Henning, Major J. Scott] Brooke Army Med Ctr, Houston, TX USA. [Firoz, Bahar F.] Methodist Hosp & DermSurg Associates, Houston, TX USA. RP Henning, MJS (reprint author), Dept Dermatol, 3851 Roger Brooke Dr, Houston, TX 78251 USA. EM Jeffrey.henning@amedd.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1076-0512 J9 DERMATOL SURG JI Dermatol. Surg. PD JAN PY 2010 VL 36 IS 1 BP 1 EP 7 DI 10.1111/j.1524-4725.2009.01377.x PG 7 WC Dermatology; Surgery SC Dermatology; Surgery GA 534JM UT WOS:000272892400001 ER PT S AU Bhatt, RT Cosgriff, LM Fox, DS AF Bhatt, Ramakrishna T. Cosgriff, Laura M. Fox, Dennis S. BE Singh, D Zhu, DM Zhou, M TI INFLUENCE OF FIBER ARCHITECTURE ON IMPACT RESISTANCE OF UNCOATED SIC/SIC COMPOSITES SO DESIGN, DEVELOPMENT, AND APPLICATIONS OF ENGINEERING CERAMICS AND COMPOSITES SE Ceramic Transactions LA English DT Proceedings Paper CT 8th Pacific Rim Conference on Ceramic and Glass Technology CY MAY 31-JUN 05, 2009 CL Vancouver, CANADA SP Amer Ceram Soc ID ENVIRONMENTAL BARRIER COATINGS; DAMAGE AB 2-D and 2.5D woven SiC/SiC composites fabricated by melt infiltration (MI) method were impact tested at ambient temperature and at 1316 degrees C in air Using 1.59-mm diameter steel-ball projectiles at velocities ranging from 115 m/s to 300 m/s. The extent of substrate damage with increasing projectile velocity was imaged and analyzed using optical microscopy, pulsed thermography, and computed tomography. Results indicate that both types of composites impact tested at ambient temperature and at 1316 degrees C showed increased surface or internal damage with increased projectile velocity. At a fixed projectile velocity, the extant of impact damage caused at ambient temperature is nearly the same as that at 1316 degrees C. Predominant impact damage mechanisms in 2-D SiC/SiC composites are fiber ply delamination, fiber fracture and matrix shearing, and in 2.5D SiC/SiC composites are fiber fracture and matrix shearing with no evidence of delamination cracks. Under similar testing conditions, the depth of projectile penetration into 2.5D SiC/SiC composites is significantly, lower than that in 2D SiC/SiC composites. C1 [Bhatt, Ramakrishna T.] NASA, Glenn Res Ctr, USA, Vehicle Technol Directorate, 21000 Brookpk Rd, Cleveland, OH 44135 USA. RP Bhatt, RT (reprint author), NASA, Glenn Res Ctr, USA, Vehicle Technol Directorate, 21000 Brookpk Rd, Cleveland, OH 44135 USA. NR 14 TC 0 Z9 0 U1 0 U2 1 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, WESTERVILLE, OH 43081-8720 USA SN 1042-1122 BN 978-0-470-88936-7 J9 CERAM TRANS PY 2010 VL 215 BP 97 EP + PG 2 WC Materials Science, Ceramics; Materials Science, Composites SC Materials Science GA BTM12 UT WOS:000287268800010 ER PT B AU Stringer, DB Allaire, PE AF Stringer, David B. Allaire, Paul E. GP ASME TI MODELING TECHNIQUES FOR DYNAMIC ANALYSIS OF A HELICOPTER TRANSMISSION SYSTEM SO DETC2009: PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES/COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE LA English DT Proceedings Paper CT ASME International Design Engineering Technical Conferences/Computers and Information in Engineering Conference CY AUG 30-SEP 02, 2009 CL San Diego, CA SP ASME, Design Engn Div, ASME, Computers & Info Engn Div DE finite element modeling; health monitoring; helicopter gearbox; sensor placement; transmission vibration ID VIBRATION AB This research presents a rotor dynamic, finite clement model of a rotary-wing transmission based on first principles. The transmission and model formulation are presented. The effects of the different gearing configurations within the model are discussed. The natural frequencies and mode shapes are extracted using conventional eigenvalue analysis. The frequencies are compared and shown to correspond with experimental results. Observations on the resulting system mode shapes arc presented. The model exhibits great potential for use in health monitoring of rotary-wing systems and sensor optimization algorithms. C1 [Stringer, David B.] USA, Res Lab, Vehicle Technol Directorate, Cleveland, OH USA. RP Stringer, DB (reprint author), USA, Res Lab, Vehicle Technol Directorate, Cleveland, OH USA. RI Stringer, D. Blake/B-3051-2017 OI Stringer, D. Blake/0000-0002-4375-2638 NR 20 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4903-3 PY 2010 BP 305 EP 311 PG 7 WC Engineering, Mechanical SC Engineering GA BRO61 UT WOS:000283272400033 ER PT B AU Pulskamp, JS Polcawich, RG Oldham, K AF Pulskamp, Jeffrey S. Polcawich, Ronald G. Oldham, Kenn GP ASME TI HIGHLY INTEGRATED PIEZOMEMS ENABLED MILLIMETER-SCALE ROBOTICS SO DETC2009: PROCEEDINGS OF THE ASME INTERNATIONAL DESIGN ENGINEERING TECHNICAL CONFERENCES/COMPUTERS AND INFORMATION IN ENGINEERING CONFERENCE LA English DT Proceedings Paper CT ASME International Design Engineering Technical Conferences/Computers and Information in Engineering Conference CY AUG 30-SEP 02, 2009 CL San Diego, CA SP ASME, Design Engn Div, ASME, Computers & Info Engn Div ID FILM PIEZOELECTRIC ACTUATORS; PZT THIN-FILMS; INSECT FLIGHT; MEMS; GENERATOR AB This report provides an overview of ongoing research at the U.S Army Research Laboratory regarding the development of piezoelectric MEMS-enabled millimeter-scale robotics Research topics include the development of enabling technologies for terrestrial locomotion, insect-inspired microflight, gecko-inspired reversible adhesives, and piezoelectric energy harvesting. The development of complementary lead zirconate titanate thin film MEMS devices, applicable to highly integrated millimeter-scale robotics, is also reviewed. C1 [Pulskamp, Jeffrey S.; Polcawich, Ronald G.] USA, Sensors & Electron Devices Div, Res Lab, Adelphi, MD 20873 USA. RP Pulskamp, JS (reprint author), USA, Sensors & Electron Devices Div, Res Lab, Adelphi, MD 20873 USA. EM jpulskamp@arl.army.mil; rpolcawich@arl.army.mil; oldham@umich.edu NR 32 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4903-3 PY 2010 BP 797 EP 805 PG 9 WC Engineering, Mechanical SC Engineering GA BRO61 UT WOS:000283272400101 ER PT S AU Bishop, S Ngaya, TA Vignola, J Judge, J Marble, J Gugino, P Soumekh, M Rosen, E AF Bishop, Steven Ngaya, Therese-Ann Vignola, Joe Judge, John Marble, Jay Gugino, Pete Soumekh, Mehrdad Rosen, Erik BE Harmon, RS Holloway, KH Broach, JT TI Outdoor Synthetic Aperture Acoustic Ground Target Measurements SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XV SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XV CY APR 05-09, 2010 CL Orlando, FL SP SPIE DE Synthetic aperture acoustics; side attack munitions; acoustic image; image reconstructions ID FORWARD-LOOKING GPR; SYSTEM AB A novel outdoor synthetic aperture acoustic (SAA) system consists of a microphone and loudspeaker traveling along a 6.3-meter rail system. This is an extension from a prior indoor laboratory measurement system in which selected targets were insonified while suspended in air. Here, the loudspeaker and microphone are aimed perpendicular to their direction of travel along the rail. The area next to the rail is insonified and the microphone records the reflected acoustic signal, while the travel of the transceiver along the rail creates a synthetic aperture allowing imaging of the scene. Ground surfaces consisted of weathered asphalt and short grass. Several surface-laid objects were arranged on the ground for SAA imaging. These included rocks, concrete masonry blocks, grout covered foam blocks; foliage obscured objects and several spherical canonical targets such as a bowling ball, and plastic and metal spheres. The measured data are processed and ground targets are further analyzed for characteristics and features amenable for discrimination. This paper includes a description of the measurement system, target descriptions, synthetic aperture processing approach and preliminary findings with respect to ground surface and target characteristics. C1 [Bishop, Steven; Marble, Jay; Gugino, Pete] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Bishop, S (reprint author), USA, RDECOM CERDEC NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. RI Judge, John/D-1429-2015 NR 25 TC 0 Z9 0 U1 1 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8128-3 J9 P SOC PHOTO-OPT INS PY 2010 VL 7664 AR 76641Y DI 10.1117/12.851802 PG 10 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSR48 UT WOS:000285543100058 ER PT S AU Glaspell, G Tabb, JS Shearer, A Wilkins, J Smith, C Massaro, R AF Glaspell, Garry Tabb, J. S. Shearer, Al Wilkins, James Smith, Clint Massaro, Ricky BE Harmon, RS Holloway, KH Broach, JT TI Utilizing Upconverting Phosphors for the Detection of TNT SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XV SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XV CY APR 05-09, 2010 CL Orlando, FL SP SPIE DE Upconverters; antibodies; TNT ID UP-CONVERSION LUMINESCENCE; Y2O3 NANOCRYSTALS; YTTRIUM-OXIDE; BLUE; RED; ERBIUM; GREEN; YB3+ AB Herein we purpose to utilize upconverting phosphors to detect explosives. To detect TNT, antibodies specific to TNT are conjugated to the surface. The role of the antibodies is two fold; to bind a quencher and to accept TNT. The quencher is a bifunctional molecule, with one end containing a TNT analog and the other end being a dark fluorescent quenching dye. The dye is chosen so that the luminescence from the phosphor will be absorbed preventing it from emitting, reducing luminescence from the phosphor. However, in the presence of TNT the quencher that is bound with DNT will be displaced. With the quencher displaced the phosphor will be able to emit light indicating TNT is present in the select area. C1 [Glaspell, Garry; Wilkins, James; Smith, Clint; Massaro, Ricky] USA, Engineer Res & Dev Ctr, Alexandria, VA 22315 USA. RP Glaspell, G (reprint author), USA, Engineer Res & Dev Ctr, 7701 Telegraph Rd, Alexandria, VA 22315 USA. NR 17 TC 0 Z9 0 U1 1 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8128-3 J9 P SOC PHOTO-OPT INS PY 2010 VL 7664 AR 76641G DI 10.1117/12.846578 PG 6 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSR48 UT WOS:000285543100042 ER PT S AU Gurton, K Felton, M Mack, R LeMaster, D Farlow, C Kudenov, M Pezzaniti, L AF Gurton, Kristan Felton, Melvin Mack, Robert LeMaster, Daniel Farlow, Craig Kudenov, Michael Pezzaniti, Larry BE Harmon, RS Holloway, KH Broach, JT TI MidIR and LWIR polarimetric sensor comparison study SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XV CY APR 05-09, 2010 CL Orlando, FL SP SPIE ID MUELLER MATRIX; ROC ANALYSIS AB We present a comparative study involving five distinctly different polarimetric imaging platforms that are designed to record calibrated Stokes images (and associated polarimetric products) in either the MidIR or LWIR spectral regions. The data set used in this study was recorded during April 14-18, 2008, at the Russell Tower Measurement Facility, Redstone Arsenal, Huntsville, AL. Four of the five camera systems were designed to operate in the LWIR (approx. 8-12 mu m), and used either cooled mercury cadmium telluride (MCT) focal-plane-arrays (FPA), or a nearroom temperature microbolometer. The lone MidIR polarimetric sensor was based on a liquid nitrogen (LN2) cooled indium antimonide (InSb) FPA, resulting in an approximate wavelength response of 3-5 mu m. The selection of cameras was comprised of the following optical designs: a LWIR "super-pixel," or division-of-focal plane (DoFP) sensor; two LWIR spinning-achromatic-retarder (SAR) based sensors; one LWIR division-of-amplitude (DoAM) sensor; and one MidIR division-of-aperture (DoA) sensor. Cross-sensor comparisons were conducted by examining calibrated Stokes images (e. g., S0, S1, S2, and degree-of-linear polarization (DOLP)) recorded by each sensor for a given target at approximately the same test periods to ensure that data sets were recorded under similar atmospheric conditions. Target detections are applied to the image set for each polarimetric sensor for further comparison, i.e., conventional receiver operating characteristic (ROC) curve analysis and an effective contrast ratio are considered. C1 [Gurton, Kristan; Felton, Melvin] USA, Res Lab, Adelphi, MD 20783 USA. RP Gurton, K (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. NR 15 TC 1 Z9 1 U1 1 U2 4 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8128-3 J9 PROC SPIE PY 2010 VL 7664 AR 76640L DI 10.1117/12.851898 PG 14 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSR48 UT WOS:000285543100018 ER PT S AU Naumann, JC Rubis, K Young, DR AF Naumann, Julie C. Rubis, Kathryn Young, Donald R. BE Harmon, RS Holloway, KH Broach, JT TI Fusing chlorophyll fluorescence and plant canopy reflectance to detect TNT contamination in soils SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XV CY APR 05-09, 2010 CL Orlando, FL SP SPIE DE Chlorophyll fluorescence; hyperspectral reflectance; photosynthesis; plant physiology; soil N; trinitrotoluene; water relations ID LEAF; STRESS; WATER; NM AB TNT is released into the soil from many different sources, especially from military and mining activities, including buried land mines. Vegetation may absorb explosive residuals, causing stress and by understanding how plants respond to energetic compounds, we may be able to develop non-invasive techniques to detect soil contamination. The objectives of our study were to examine the physiological response of plants grown in TNT contaminated soils and to use remote sensing methods to detect uptake in plant leaves and canopies in both laboratory and field studies. Differences in physiology and light-adapted fluorescence were apparent in laboratory plants grown in N enriched soils and when compared with plants grown in TNT contaminated soils. Several reflectance indices were able to detect TNT contamination prior to visible signs of stress, including the fluorescence-derived indices, R-740/R-850 and R-735/R-850, which may be attributed to transformation and conjugation of TNT metabolites with other compounds. Field studies at the Duck, NC Field Research Facility revealed differences in physiological stress measures, and leaf and canopy reflectance when plants growing over suspected buried UXOs were compared with reference plants. Multiple reflectance indices indicated stress at the suspected contaminated sites, including R-740/R-850 and R-735/R-850. Under natural conditions of constant leaching of TNT into the soil, TNT uptake would be continuous in plants, potentially creating a distinct signature from remotely sensed vegetation. We may be able to use remote sensing of plant canopies to detect TNT soil contamination prior to visible signs. C1 [Naumann, Julie C.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. RP Naumann, JC (reprint author), USA, Erdc, Fluorescence Spect Lab, 7701 Telegraph Rd, Alexandria, VA 22315 USA. EM Julie.C.Naumann@usace.army.mil NR 18 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8128-3 J9 PROC SPIE PY 2010 VL 7664 AR 76641L DI 10.1117/12.851220 PG 7 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSR48 UT WOS:000285543100047 ER PT S AU O'Neill, K Barrowes, BE Shubitidze, F Fernandez, JP Grzegorczyk, TM Shamatava, I AF O'Neill, Kevin Barrowes, Benjamin E. Shubitidze, Fridon Fernandez, Juan Pablo Grzegorczyk, Tomasz M. Shamatava, Irma BE Harmon, RS Holloway, KH Broach, JT TI Upward continuation of EMI data for sensing of subsurface UXO in cluttered, multi-object cases SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XV SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XV CY APR 05-09, 2010 CL Orlando, FL SP SPIE DE Unexploded ordnance; UXO; Electromagnetic induction; EMI; subsurface; clutter; upward continuation; TEMTADS AB In subsurface UXO sensing, single field (SF) data arises when an excitation field produces a single, spatially distributed response field that is sampled from a number of different locations. Measurements from traditional magnetometers furnish such data, for which the essentially invariant excitation is the earth's magnetic field. Upward continuation (UC) of SF data allows one to calculate signals that would be received at a higher elevation above the ground without actually raising the receiver. This is done without having to solve for the actual target characteristics or location. The technique is designed to smooth out the perturbations from irregularities and near-surface clutter. Applied recently to broader band electromagnetic induction (EMI) data of the the GAP SAM system, UC has shown distinct benefits in suppressing the strength of near surface clutter signals relative to those from a deeper UXO. Here we investigate possible application to the TEMTADS sensor. Preliminary results suggest that here too the method may bring out the signal of an underlying larger UXO relative to discrete clutter or smaller shallowers items, thereby aiding discrimination. In future work resolution issues must be addressed. C1 [O'Neill, Kevin; Barrowes, Benjamin E.] ERDC CRREL, Hanover, NH 03755 USA. RP O'Neill, K (reprint author), ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. EM Kevin.O'Neill@usace.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8128-3 J9 P SOC PHOTO-OPT INS PY 2010 VL 7664 AR 76640C DI 10.1117/12.850441 PG 11 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSR48 UT WOS:000285543100011 ER PT S AU Trang, A Agarwal, S Broach, T Smith, T AF Trang, Anh Agarwal, Sanjeev Broach, Thomas Smith, Thomas BE Harmon, RS Holloway, KH Broach, JT TI Exploiting spatial distributions for minefield detection in cluttered environment SO DETECTION AND SENSING OF MINES, EXPLOSIVE OBJECTS, AND OBSCURED TARGETS XV SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Detection and Sensing of Mines, Explosive Objects, and Obscured Targets XV CY APR 05-09, 2010 CL Orlando, FL SP SPIE DE Mine detection; minefield detection; spatial distribution; patterned minefield; scatterable minefield; Markov marked point process; maximum log-likelihood ID PATTERN AB Spectral, shape and texture features of the detected targets are used to model the likelihood of detections to be potential mines in a minefield. However, a large number of these potential mines can be false alarms due to the similarity of the mine signatures with natural and other manmade clutter objects which significantly affects the overall detection performance. In addition to the spectral features, spatial distribution of the detected targets can be used to improve the minefield detection performance. In this paper, spectral features and spatial distributions are used simultaneously for minefield detection. We use nearest neighbor distances of the detected targets to capture the spatial characteristics of the minefields. We investigate the spatial distributions and evaluate minefield performance for both patterned and scatterable minefields in a cluttered environment where the number of detected mines is many times less than the number of false alarms. For patterned minefields, performance for minefields with different number of rows at different mine false alarm rates is evaluated. For scatterable minefields, we evaluate the performance of minefields where potential mines are randomly and regularly distributed. In all cases, the false alarms are assumed to be spatially randomly distributed. The performance of the proposed detection algorithm is compared to the baseline algorithm using extensive simulated minefield data. C1 [Trang, Anh; Agarwal, Sanjeev; Broach, Thomas; Smith, Thomas] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA USA. RP Trang, A (reprint author), USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA USA. NR 16 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8128-3 J9 P SOC PHOTO-OPT INS PY 2010 VL 7664 AR 766426 DI 10.1117/12.851488 PG 12 WC Remote Sensing; Optics SC Remote Sensing; Optics GA BSR48 UT WOS:000285543100065 ER PT S AU Wijewarnasuriya, PS AF Wijewarnasuriya, Priyalal S. BE Dereniak, EL Hartke, JP LeVan, PD Longshore, RE Sood, AK Razeghi, M Sudharsanam, R TI Nonequilibrium Operation of Long Wavelength HgCdTe Photo Detectors For Higher Operating temperatures SO DETECTORS AND IMAGING DEVICES: INFRARED, FOCAL PLANE, SINGLE PHOTON SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Detectors and Imaging Devices - Infrared, Focal Plane, Single Photon CY AUG 04-05, 2010 CL San Diego, CA SP SPIE DE Auger suppression; nonequilibrium; photovoltaic devices; arsenic p-type doping; molecular beam epitaxy; HgCdTe; long wavelength; infrared devices ID MOLECULAR-BEAM EPITAXY; INFRARED DETECTION; DEVICES; PHOTODIODES; HG1-XCDXTE; LIFETIME AB Our fundamental approach was to increase the operating temperature of the device by reducing the volume of its diffusion region, while maintaining the performance at low temperatures. Reducing the diffusion volume of a detector can be achieved by reducing the active layer thickness, reducing the absorber volume, and reducing the junction area while maintaining the optical area as the original pixel by using micro-lens technology on pixel levels, etc. We are pursuing an infrared device with a unique planar architecture that uses a novel approach in obtaining low arsenic doping concentrations in long-wavelength (LW) mercury cadmium telluride (HgCdTe) on CdZnTe substrates for higher temperature applications. We fabricated a p-on-n structure that we term P+/p/N+, where the symbol "p'' indicates a drastically reduced extrinsic p-type carrier concentration (on the order of mid-10(15) cm(-3)); P+ and N+ denote a higher doping density, as well as a higher energy gap, than the photosensitive base p-region. Fabricated devices indicated that Auger suppression is seen in the P+/p/N+ architecture at temperatures above 130 K; we obtained saturation currents on the order of 3 mAmps on 250-mu m-diameter devices at 300 K with Auger suppression. Data shows that roughly 50% reduction in dark current is achieved at 300 K due to Auger suppression. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Wijewarnasuriya, PS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 18 TC 1 Z9 1 U1 0 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8276-1 J9 PROC SPIE PY 2010 VL 7780 AR 77800A DI 10.1117/12.870920 PG 14 WC Optics; Physics, Applied; Imaging Science & Photographic Technology SC Optics; Physics; Imaging Science & Photographic Technology GA BTS05 UT WOS:000287928300006 ER PT B AU McClung, JP Peterson, DG AF McClung, James P. Peterson, Daniel G. BE Watson, RR Zibadi, S Preedy, VR TI Trace Elements and Immune Function SO DIETARY COMPONENTS AND IMMUNE FUNCTION SE Nutrition and Health Series LA English DT Article; Book Chapter DE Trace elements; minerals; immune function; copper; iron; selenium; zinc ID SELENIUM-DEFICIENT MICE; PAPUA-NEW-GUINEA; COPPER DEFICIENCY; ZINC SUPPLEMENTATION; INFECTIOUS-DISEASE; IRON-DEFICIENCY; RATS; LYMPHOCYTES; PHYSIOLOGY; INCREASES C1 [McClung, James P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Peterson, Daniel G.] Calif Polytech State Univ San Luis Obispo, Dept Anim Sci, San Luis Obispo, CA 93407 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM james.mcclung@amedd.army.mil; dpeterso@calpoly.edu NR 55 TC 1 Z9 1 U1 1 U2 2 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DR, STE 208, TOTOWA, NJ 07512-1165 USA BN 978-1-60761-060-1 J9 NUTR HEALTH SER JI Nutr. Health Ser. PY 2010 BP 253 EP 262 DI 10.1007/978-1-60761-061-8_14 D2 10.1007/978-1-60761-061-8 PG 10 WC Immunology; Nutrition & Dietetics SC Immunology; Nutrition & Dietetics GA BQK34 UT WOS:000281202700014 ER PT S AU Wilson, D Lavine, MK AF Wilson, Duane Lavine, Michael K. BE Goel, S TI A Discretionary Access Control Method for Preventing Data Exfiltration (DE) via Removable Devices SO DIGITAL FORENSICS AND CYBER CRIME SE Lecture Notes of the Institute for Computer Sciences Social Informatics and Telecommunications Engineering LA English DT Proceedings Paper CT 1st International Conference on Digital Forensics and Cyber Crime (ICDF2C) CY SEP 30-OCT 02, 2009 CL Albany, NY SP Create Net, ASR Data, Guardian Software, Guidance Software, Springer Link DE Data ex filtration; extended file attributes; alternate data streams AB One of the major challenges facing the security community today is how to prevent DE. DE is the unauthorized release of information from a computer system or network of systems. Current methods attempt to address this issue by controlling the information that is released over the Internet. In this paper, we present a host-level discretionary access control method that focuses on exfiltration via removable devices (e.g. thumb drives or external hard drives). Using XML to store extended file attributes, we classify tiles based on user-defined distribution levels and the community of interest to which they belong. Files are classified with a distribution statement upon creation and re-classified (if necessary) when modified. By monitoring the access to all classified files present on a file system, we allow or prevent release of this information based on predefined policies. With this approach, we show that the unauthorized release of information can be prevented by using a system of accounting that is tied to access control policies. Users are given the authority to transfer files to a removable device according to their current access rights. As a proof of concept, our method demonstrates the value of using accounting as a means of preventing data loss or theft. Our approach can be applied to a variety of data types found on a file system including: executables, archived files, images, and even audio or video tiles. C1 [Wilson, Duane] USA, Network Secur Branch, Res Lab, Adelphi, MD 20783 USA. [Lavine, Michael K.] Johns Hopkins Univ, Informat Secur Inst, Baltimore, MD 21205 USA. RP Wilson, D (reprint author), USA, Network Secur Branch, Res Lab, Adelphi, MD 20783 USA. EM dwilson@arl.army.mil; mlavine@jhu.edu NR 9 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1867-8211 BN 978-3-642-11533-2 J9 L N INST COMP SCI SO PY 2010 VL 31 BP 151 EP + PG 2 WC Computer Science, Information Systems; Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BZY47 UT WOS:000303374200015 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI New age of warfare: How digital forensics is reshaping today's military SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Article; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP 1 EP 11 DI 10.1016/B978-1-59749-596-7.00001-2 PG 11 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600003 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI Digital Triage Forensics Processing the Digital Crime Scene Preface SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Editorial Material; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP VII EP VII DI 10.1016/B978-1-59749-596-7.00011-5 PG 1 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600001 ER PT J AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI Introduction: Using the digital triage forensics model to collect and process cell phones and SIM cards SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Editorial Material; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP IX EP XI DI 10.1016/B978-1-59749-596-7.00012-7 PG 3 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600002 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI Digital triage forensics and battlefield forensics SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Article; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP 13 EP 24 DI 10.1016/B978-1-59749-596-7.00002-4 PG 12 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600004 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI Conducting pre/postblast investigations SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Article; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP 25 EP 56 DI 10.1016/B978-1-59749-596-7.00003-6 PG 32 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600005 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI Using the DTF model to process digital media SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Article; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP 57 EP 143 DI 10.1016/B978-1-59749-596-7.00004-8 PG 87 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600006 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI Using the DTF model to collect and process cell phones and SIM cards SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Article; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP 145 EP 250 DI 10.1016/B978-1-59749-596-7.00005-X PG 106 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600007 ER PT B AU Pearson, S Watson, R Harrington, M AF Pearson, Stephen Watson, Richard Harrington, Michael BA Pearson, S Watson, R BF Pearson, S Watson, R TI The changing role of a digital forensic investigator SO DIGITAL TRIAGE FORENSICS: PROCESSING THE DIGITAL CRIME SCENE LA English DT Article; Book Chapter C1 [Pearson, Stephen] USA, Mil Police Sch, Ft McClellan, AL USA. RP Pearson, S (reprint author), Webster Univ, St Louis, MO 63119 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-1-59749-597-4 PY 2010 BP 251 EP 255 DI 10.1016/B978-1-59749-596-7.00006-1 PG 5 WC Medicine, Legal SC Legal Medicine GA BEF56 UT WOS:000316405600008 ER PT J AU Thompson, WC AF Thompson, Wiley C. TI Success in Kashmir: a positive trend in civil-military integration during humanitarian assistance operations SO DISASTERS LA English DT Article DE disaster relief; earthquake; humanitarian assistance; Kashmir; military; NGO ID DISASTER RELIEF; INTERVENTION; COORDINATION; EARTHQUAKE; CRISES AB The modern cast of disaster relief actors includes host nations, non-governmental organisations, private volunteer organisations, military organisations and others. Each group, civilian or military, has valuable skills and experiences critical to disaster relief work. The goal of this paper is to supplement the study of civil-military relief efforts with contemporary anecdotal experience. The paper examines the interaction between US military forces and other disaster relief actors during the 2005 Kashmir earthquake relief effort. The author uses direct observations made while working in Pakistan to contrast the relationships and activities from that effort with other accounts in prevailing scholarly disaster literature and military doctrine. Finally, this paper suggests that the Kashmir model of integration, coordination and transparency of intent creates a framework in which future humanitarian assistance operations could be successfully executed. Recommendations to improve civil-military interaction in future relief efforts will also be addressed. C1 US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Thompson, WC (reprint author), US Mil Acad, Dept Geog & Environm Engn, 745 Brewerton Rd, West Point, NY 10996 USA. EM wiley.thompson@usma.edu NR 31 TC 4 Z9 4 U1 3 U2 17 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0361-3666 J9 DISASTERS JI Disasters PD JAN PY 2010 VL 34 IS 1 BP 1 EP 15 DI 10.1111/j.0361-3666.2009.01111.x PG 15 WC Planning & Development SC Public Administration GA 524UV UT WOS:000272170400002 PM 19459902 ER PT J AU Greenwald, BD Dumot, JA Horwhat, JD Lightdale, CJ Abrams, JA AF Greenwald, Bruce D. Dumot, John A. Horwhat, J. David Lightdale, Charles J. Abrams, Julian A. TI Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagus SO DISEASES OF THE ESOPHAGUS LA English DT Article DE Barrett esophagus; catheter ablation; cryosurgery; cryotherapy; esophageal neoplasm; safety ID ARGON PLASMA COAGULATION; HIGH-GRADE DYSPLASIA; BARRETTS-ESOPHAGUS; PHOTODYNAMIC THERAPY; MULTIPOLAR ELECTROCOAGULATION; ACID SUPPRESSION; CONTROLLED-TRIAL; ABLATION; MULTICENTER; ERADICATION AB Endoscopic cryotherapy is a new technique for ablation of esophageal dysplasia and neoplasia. Preliminary studies have shown it to be safe and effective for this indication. The objective of this study is to characterize safety, tolerability, and efficacy of low-pressure liquid nitrogen endoscopic spray cryotherapy ablation in a large cohort across multiple study sites. Parallel prospective treatment studies at four tertiary care academic medical centers in the U. S. assessed spray cryotherapy in patients with Barrett's esophagus with or without dysplasia, early stage esophageal cancer, and severe squamous dysplasia who underwent cryotherapy ablation of the esophagus. All patients were contacted between 1 and 10 days after treatment to assess for side effects and complications of treatment. The main outcome measurement was the incidence of serious adverse events and side effects from treatment. Complete response for high-grade dysplasia (HGD) (CR-HGD), all dysplasia (CR-D), intestinal metaplasia (CR-IM) and cancer (CR-C) were assessed in patients completing therapy during the study period. A total of 77 patients were treated for Barrett's high-grade dysplasia (58.4%), intramucosal carcinoma (16.9%), invasive carcinoma (13%), Barrett's esophagus without dysplasia (9.1%), and severe squamous dysplasia (2.6%). Twenty-two patients (28.6%) reported no side effects throughout treatment. In 323 procedures, the most common complaint was chest pain (17.6%) followed by dysphagia (13.3%), odynophagia (12.1%), and sore throat (9.6%). The mean duration of any symptoms was 3.6 days. No side effects were reported in 48% of the procedures (155/323). Symptoms did not correlate with age, gender, diagnosis, or to treatment early versus late in the patient's or site's experience. Logit analysis showed that symptoms were greater in those with a Barrett's segment of 6 cm or longer. Gastric perforation occurred in one patient with Marfan's syndrome. Esophageal stricture developed in three, all successfully treated with dilation. In 17 HGD patients, cryotherapy produced CR-HGD, CR-D, and CR-IM of 94%, 88%, and 53%, respectively. Complete regression of cancer and HGD was seen in all seven patients with intramucosal carcinoma or stage I esophageal cancer. Endoscopic spray cryotherapy ablation using low-pressure liquid nitrogen in the esophagus is safe, well-tolerated, and efficacious. C1 [Greenwald, Bruce D.] Univ Maryland, Div Gastroenterol & Hepatol, Dept Med, Sch Med, Baltimore, MD 21201 USA. [Greenwald, Bruce D.] Greenebaum Canc Ctr, Baltimore, MD USA. [Dumot, John A.] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH 44106 USA. [Horwhat, J. David] Walter Reed Army Med Ctr, Dept Med, Gastroenterol Serv, Washington, DC 20307 USA. [Lightdale, Charles J.; Abrams, Julian A.] Columbia Univ, Div Digest & Liver Dis, New York, NY USA. RP Greenwald, BD (reprint author), Univ Maryland, Div Gastroenterol & Hepatol, Dept Med, Sch Med, 22 S Greene St,Rm N3W62, Baltimore, MD 21201 USA. EM bgreenwa@medicine.umaryland.edu FU CSA Medical, Inc.; University of Maryland; Cleveland Clinic Foundation; National Cancer Institute [CA132892] FX CSA Medical, Inc. provided financial support for data collection and statistical analysis. However, CSA Medical, Inc. had no role in the analysis and interpretation of the data, the preparation, review, or approval of the manuscript, or the decision to publish the findings. CSA Medical, Inc. also provided research support at the University of Maryland and Cleveland Clinic Foundation to conduct the treatment studies. The Maryland Industrial Partnerships Program provided research funding at the University of Maryland. Dr. Abrams was supported in part by a K07 award from the National Cancer Institute (CA132892). NR 20 TC 43 Z9 44 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1120-8694 J9 DIS ESOPHAGUS JI Dis. Esophagus PY 2010 VL 23 IS 1 BP 13 EP 19 DI 10.1111/j.1442-2050.2009.00991.x PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 546PA UT WOS:000273821500003 PM 19515183 ER PT B AU Yuan, FP Tsai, LR Prakash, V Dandekar, DP Rajendran, AM AF Yuan, Fuping Tsai, Liren Prakash, Vikas Dandekar, Dattatraya P. Rajendran, A. M. BE Shukla, A Ravichandran, G Rajapakse, YDS TI Dynamic Response of Glass-Fiber Reinforced Polymer Composites Under Shock Wave Loading SO DYNAMIC FAILURE OF MATERIALS AND STRUCTURES LA English DT Article; Book Chapter DE S2 glass fiber reinforced composites; Shock-induced compression; Combined pressure and shear loading; Dynamic spall strength; Shock Hugoniot; Hugoniot elastic limit ID LAMINATED COMPOSITES; EPOXY COMPOSITE; INTEGRAL ARMOR; STRENGTH; IMPACT; DELAMINATION; ALUMINUM; BEHAVIOR AB Synthetic heterogeneous material systems, for example, layered composite materials with organic matrices reinforced by glass fiber reinforces polymers (GRPs), are attractive for a variety of lightweight structural applications. This chapter deals with the dynamic response of layered heterogeneous material systems, such as the GRPs, under shock wave loading conditions. To understand material and geometric dispersion of stress waves in the GRPs, these are modeled as elastic-elastic and/or elastic-viscoelastic bilaminates. The analysis makes use of the Laplace transform and Floquet theory for Ordinary Differential Equations (ODEs) with periodic coefficients. Both wave front and late-time solutions for step-pulse loading on a layered half-space are analyzed. The results of the analytical study show that the structure of acceleration waves is strongly influenced by impedance mismatch of the layers constituting the laminates, density of interfaces, distance of wave propagation, and the material inelasticity. Next, series of plate impact experiments are conducted on two different architectures of GRP composites - S2-glass woven roving in CYCOM 4102 polyester resin matrix and a balanced 5-harness satin weave E-glass in a Ciba epoxy (LY564) matrix. The experiments are conducted using an 82.5 mm bore single-stage gas-gun at CWRU. In all experiments, the history of the shock-induced free-surface particle velocity profiles at the rear surface of the target plate are monitored using a multibeam VALYN (TM) VISAR. In the first series of experiments, the structure of the shock waves in the S2-glass GRP is investigated as a function of shock-induced compression and the distance of shock wave propagation. The results of the experiments show the absence of an elastic precursor. The critical shock stress amplitude at which a clear shock front is seen to develop in the GRP was determined to be between 1.5 and 2.0 GPa. Combining the results of the present experiments with data from Dandekar et al. (1998, 2003a), the equation of state (EOS) of the S2-glass GRP was determined in the stress range of 0.04-20 GPa. Besides the EOS, the Hugoniot curve (Hugoniot stress vs Hugoniot strain) was calculated using the Rankine-Hugoniot relationships; the Hugoniot elastic limit (HEL) of the S2-glass GRP was estimated to be about 1.6 GPa. In the second series experiments, the postshock spall strengths of the S2-glass and E-glass GRP composites were investigated by subjecting the specimens to shock compression and combined shock compression and shear loadings. The spall strengths of the two GRP composites were observed to decrease with increasing levels of shock compression. Moreover, superposition of shear-strain on the normal shock compression was found to be highly detrimental to the spall strengths. The E-glass GRP composite was found to have a much higher level of spall strength under both normal-compression and combined compression-and-shear loading conditions in comparison to the S2-glass composite. The maximum spall strength of the E-glass GRP was 119.5 MPa, while the maximum spall strength for the S2-glass GRP was only 53.7 MPa. In the third series of experiments, plate impact shock-reshock and shock release experiments were conducted to study the residual shear strength of the S2-glass GRP under various levels of shock compression (0.8-1.8 GPa). To conduct these experiments, a dual flyer plate assembly was used. Using the self-consistent procedure outlined in Asay and Chhabildas (1981), the critical shear strength following shock-induced compression (in the rane 0.8-1.8 GPa) was determined. The results indicate that the critical shear strength of the GRP increases from 0.108 to 0.682 GPa when the shock compression level is increased from 0.8 to 1.8 GPa. This increase in critical shear strength may be attributed to the rate-dependence and/or pressure-dependent yield behavior of the GRP composites. C1 [Yuan, Fuping; Prakash, Vikas] Case Western Reserve Univ, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA. [Tsai, Liren] Natl Chiao Tung Univ, Dept Mech Engn, Hsinchu 300, Taiwan. [Rajendran, A. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. [Dandekar, Dattatraya P.] USA, Res Lab, AMSRD ARL WM TD, Aberdeen Proving Ground, MD 21005 USA. RP Yuan, FP (reprint author), Case Western Reserve Univ, Dept Mech & Aerosp Engn, Cleveland, OH 44106 USA. EM Fuping.Yuan@case.edu; vikas.prakash@case.edu; ddandek@arl.army.mil; raj@arl.aro.army.mil NR 39 TC 1 Z9 1 U1 2 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-0445-4 PY 2010 BP 63 EP 106 DI 10.1007/978-1-4419-0446-1_3 D2 10.1007/978-1-4419-0446-1 PG 44 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA BMD17 UT WOS:000271892200003 ER PT B AU Rajendran, AM AF Rajendran, A. M. BE Shukla, A Ravichandran, G Rajapakse, YDS TI Advanced Numerical Simulation of Failure in Solids Under Blast and Ballistic Loading: A Review SO DYNAMIC FAILURE OF MATERIALS AND STRUCTURES LA English DT Review; Book Chapter DE Blast; Dynamic fracture; Shock wave propagation; Hydrocodes; Projectile penetration; Diagnostics penetration experiments; Particles methods; Adaptive mesh; Contact ID LONG-ROD PENETRATION; TARGETS; PROJECTILES; IMPACT; PLATES; SHOCK AB Analyses of structural response to blast and projectile penetration require advanced computational modeling. The problems are geometrically and materially nonlinear. Accuracy of the solutions is sensitive to several numerical algorithms: robust contact, air blast/structure coupling, nonlinear error estimation, adaptive mesh, and cohesive element. Description of the damage and failure processes demand high mesh resolution and often extremely small time steps. If the localization phenomenon leads to large-scale plastic yielding and large deformations, the accuracy of the solution tends to depend on our ability to capture the time and space resolved extreme gradients of stress, strain, and other internal state variables. This chapter discusses the computational requirements on the accurate modeling of structure, armor, and projectile responses as well as the blast phenomenon. C1 [Rajendran, A. M.] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Rajendran, A. M.] Univ Mississippi, Dept Mech Engn, University, MS 38677 USA. RP Rajendran, AM (reprint author), USA, Res Off, Res Triangle Pk, NC 27709 USA. EM raj@arl.aro.army.mil NR 47 TC 0 Z9 0 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES BN 978-1-4419-0445-4 PY 2010 BP 327 EP 347 DI 10.1007/978-1-4419-0446-1_11 D2 10.1007/978-1-4419-0446-1 PG 21 WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA BMD17 UT WOS:000271892200011 ER PT B AU Lebeda, FJ Cer, RZ Stephens, R Mudunuri, U AF Lebeda, Frank J. Cer, Regina Z. Stephens, Robert Mudunuri, Uma BE Kurstot, J Forsstrom, M TI Time Course of the Effects of Botulinum Neurotoxin SO DYSTONIA: CAUSES, SYMPTOMS AND TREATMENT SE Neurology Laboratory and Clinical Research Series LA English DT Article; Book Chapter ID TOXIN TYPE-A; MOUSE NEUROMUSCULAR-JUNCTIONS; CERVICAL DYSTONIA; CLOSTRIDIAL NEUROTOXINS; DOUBLE-BLIND; MASS-SPECTROMETRY; INDUCED PARALYSIS; LIGHT-CHAIN; TRANSLOCATION; EFFICACY AB Of the seven immunologically distinct forms of the bacterial protein botulinum neurotoxin, serotypes A and B are currently the most widely used in the pharmaceutical treatment of the dystonias. In this study, we have outlined our approach in finding time-related clinical data, (e.g., onset times, durations of effect) from systematically mining the biomedical literature. These values are being integrated into mathematical frameworks to further our understanding of the therapeutic effects of the neurotoxin at the molecular and cellular levels. Potentially, these models could be of use in personalized medicine by making accurate predictions of individual patient responses to small doses of administered toxin. C1 [Lebeda, Frank J.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 20701 USA. [Cer, Regina Z.; Stephens, Robert; Mudunuri, Uma] NCI Frederick, Adv Biomed Comp Ctr, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21702 USA. RP Lebeda, FJ (reprint author), USA, Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 20701 USA. NR 60 TC 1 Z9 1 U1 0 U2 1 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 978-1-60876-445-7 J9 NEUROL LAB CLIN RES PY 2010 BP 179 EP 198 PG 20 WC Clinical Neurology SC Neurosciences & Neurology GA BPO29 UT WOS:000279531400007 ER PT J AU Muinonen, K Tyynela, J Zubko, E Videen, G AF Muinonen, Karri Tyynela, Jani Zubko, Evgenij Videen, Gorden TI Scattering parameterization for interpreting asteroid polarimetric and photometric phase effects SO EARTH PLANETS AND SPACE LA English DT Article; Proceedings Paper CT 5th Annual Meeting of the Asia-Oceania-Geoscience-Society CY JUN 16-20, 2008 CL Busan, SOUTH KOREA SP Asia Oceania Geosci Soc DE Light scattering; coherent backscattering; photometry; polarimetry; cosmic dust; small particle; negative polarization; opposition effect ID GAUSSIAN RANDOM PARTICLES; INTERNAL ELECTRIC-FIELDS; LIGHT-SCATTERING AB We derive an analytical parameterization of the amplitude and Mueller scattering matrices of it System composed of a small number of electric dipoles. The appeal of this derivation is that it provides a wide range of light-scattering polarization states with a minimal number of parameters. Such a tool call be used to interpret observations in terms of physical parameters. We aim to utilize these results ill multiple-scattering studies. Such as the interpretation of polarimetric and photometric phase effects of asteroids and other atmosphereless solar-system objects. C1 [Muinonen, Karri; Tyynela, Jani] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Zubko, Evgenij] Tohoku Univ, Grad Sch Sci, Ctr Atmospher & Ocean Studies, Aoba Ku, Sendai, Miyagi 9808578, Japan. [Zubko, Evgenij] Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. [Videen, Gorden] USA, Res Lab, CI ES, Adelphi, MD 20783 USA. RP Muinonen, K (reprint author), Univ Helsinki, Dept Phys, POB 14, FI-00014 Helsinki, Finland. EM karri.muinonen@helsinki.fi RI Tyynela, Jani/H-4761-2011 NR 12 TC 7 Z9 7 U1 0 U2 6 PU TERRA SCIENTIFIC PUBL CO PI TOKYO PA 2003 SANSEI JIYUGAOKA HAIMU, 5-27-19 OKUSAWA, SETAGAYA-KU, TOKYO, 158-0083, JAPAN SN 1343-8832 J9 EARTH PLANETS SPACE JI Earth Planets Space PY 2010 VL 62 IS 1 BP 47 EP 52 DI 10.5047/eps.2009.01.001 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 563TH UT WOS:000275156600008 ER PT S AU Espinola, RL Steinvall, O Elmquist, M Karlsson, K AF Espinola, Richard L. Steinvall, Ove Elmquist, Magnus Karlsson, Kjell BE Kamerman, GW Steinvall, O Lewis, KL Hollins, RC Merlet, TJ Bishop, GJ Gonglewski, JD TI Modeling of 1.5 mu m range gated imaging for small surface vessel identification SO ELECTRO-OPTICAL REMOTE SENSING, PHOTONIC TECHNOLOGIES, AND APPLICATIONS IV SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Electro-Optical Remote Sensing, Photonic Technologies, and Applications IV CY SEP 20-23, 2010 CL Toulouse, FRANCE SP SPIE, Electro Magnet Remote Sensing Defence Technol Ctr, SFO DE Laser range gated; SWIR; imaging; sensor performance modeling; maritime security ID TARGET ACQUISITION PERFORMANCE AB Within the framework of the NATO group (NATO SET-132/RTG-72) on imaging ladars, a test was performed to collect simultaneous multi-mode LADAR signatures of maritime objects entering and leaving San Diego Harbor. Beside ladars, passive sensors were also employed during the test which occurred during April 2009 from Point Loma and the harbor in San Diego. This paper will report on 1.5 mu m gated imaging on a number of small civilian surface vessels with the aim to present human perception experimental results and comparisons with sensor performance models developed by US Army RDECOM CERDEC NVESD. We use controlled human perception tests to measure target identification performance and compare the experimental results with model predictions. C1 [Espinola, Richard L.] USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. RP Espinola, RL (reprint author), USA, RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. NR 9 TC 2 Z9 2 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8353-9 J9 PROC SPIE PY 2010 VL 7835 AR 78350B DI 10.1117/12.865076 PG 9 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BTP50 UT WOS:000287709400009 ER PT S AU Jiang, JH Aulich, TR Collings, ME Sohn, CW AF Jiang, Junhua Aulich, Ted R. Collings, Michael E. Sohn, Chang W. BE Lvov, SN Subramanian, VR Weidner, JW Williams, M TI High-Pressure Electrochemical Hydrogen Purification Process Using a High-Temperature Polybenzimidazole (PBI) Membrane SO ELECTROCHEMICAL TECHNOLOGIES FOR HYDROGEN PRODUCTION SE ECS Transactions LA English DT Proceedings Paper CT Symposium on Electrochemical Technologies for Hydrogen Production held during the 217th Meeting of the Electrochemical-Society CY APR 25-30, 2010 CL Vancouver, CANADA SP Electrochem Soc (ECS), Ind Electrochemistry & Electrochem Engn, Energy Technol, High Temp Mat ID FUEL-CELLS; CONDUCTIVITY; OPERATION AB A high-pressure electrochemical hydrogen purification system comprising a two-chamber electrochemical cell and fully automatic flow, pressure, and temperature control units has been successfully constructed. The electrochemical hydrogen purification process using a high-temperature polybenzimidazole membrane and Pt electrocatalysts has been investigated via polarization measurements and product analysis at elevated pressure. Measured linear potential-current curves demonstrate high electrode polarizations in simulated reformate gas containing hydrogen, carbon monoxide, and carbon dioxide. The adsorption of both CO and CO2 onto Pt electrocatalysts at increased pressure has been proposed to be responsible for the high electrode polarizations. The gas chromatography analysis of cathode products suggests that high-purity hydrogen could be obtained at the cathode side, albeit with a small amount of CO2 as impurity. Further research on the optimization of the high-pressure electrochemical purification process for minimized electrode polarizations and maximized hydrogen purity is under way at the Energy and Environmental Research Center. C1 [Jiang, Junhua; Aulich, Ted R.; Collings, Michael E.] Univ N Dakota, Energy & Environm Res Ctr, 15 North 23rd St, Grand Forks, ND 58202 USA. [Sohn, Chang W.] US Army, Engn Res & Dev Ctr Construct, Energy Branch, Champaign, IL 61826 USA. RP Jiang, JH (reprint author), Univ N Dakota, Energy & Environm Res Ctr, 15 North 23rd St, Grand Forks, ND 58202 USA. RI Jiang, Junhua/D-2645-2017 OI Jiang, Junhua/0000-0003-2437-9812 FU U.S. Army ERDC-CERL FX We appreciate financial support from the U.S. Army ERDC-CERL, and technical assistance provided by Tim Kujawa, Jerry Petersburg, John Richter, Ron Kulas and Dennis Kyle at the EERC. NR 11 TC 0 Z9 0 U1 0 U2 2 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-56677-852-7 J9 ECS TRANSACTIONS PY 2010 VL 28 IS 26 BP 91 EP 100 DI 10.1149/1.3501098 PG 10 WC Electrochemistry SC Electrochemistry GA BDW88 UT WOS:000315446500008 ER PT J AU Wildman, RA Weile, DS AF Wildman, Raymond A. Weile, Daniel S. TI Inverse Scattering of Dielectric Cylindrical Targets Using Genetic Programming SO ELECTROMAGNETICS LA English DT Article; Proceedings Paper CT 9th International Workshop on Finite Elements for Microwave Engineering CY MAY 08-09, 2008 CL Bonn, GERMANY DE genetic programming; genetic algorithms; inverse scattering; computational geometry ID CONDUCTING CYLINDERS; ALGORITHM AB A genetic programming method for solving inverse scattering problems involving cylindrical targets composed of either homogeneous or inhomogeneous dielectrics is presented. Specifically, a tree-shaped chromosome is used to combine convex polygons using either Boolean operations (for homogeneous targets) or an overlapping scheme (for inhomogeneous targets). Convex polygons residing in the terminal nodes of the tree are represented as the convex hull of a variable length list of points. Genetic programming then optimizes the geometry and topology of the target along with all material values. Results show that the method is accurate for a broad class of scattering targets. C1 [Weile, Daniel S.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA. [Wildman, Raymond A.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen, MD USA. RP Weile, DS (reprint author), Univ Delaware, Dept Elect & Comp Engn, 140 Evans Hall, Newark, DE 19716 USA. EM weile@ee.udel.edu NR 18 TC 1 Z9 1 U1 0 U2 3 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0272-6343 J9 ELECTROMAGNETICS JI Electromagnetics PY 2010 VL 30 IS 1-2 SI SI BP 222 EP 236 AR PII 919723416 DI 10.1080/02726340903485513 PG 15 WC Engineering, Electrical & Electronic SC Engineering GA 565FV UT WOS:000275275700014 ER PT S AU Ouellette, GD Buckley, PE O'Connell, KP AF Ouellette, Gary D. Buckley, Patricia E. O'Connell, Kevin P. BE OConnell, KP Skowronski, EW Sulakvelidze, A Bakanidze, L TI Environmental Influences on the Relative Stability of Baculoviruses and Vaccinia Virus: A Review SO EMERGING AND ENDEMIC PATHOGENS: ADVANCES IN SURVEILLANCE, DETECTION AND IDENTIFICATION SE NATO Science for Peace and Security Series A-Chemistry and Biology LA English DT Proceedings Paper CT NATO Advanced Research Workshop on Advances in Surveillance, Detection and Identification of Emerging and Endemic Pathogens CY JUN 24-26, 2008 CL Tbilisi, REP OF GEORGIA ID NUCLEAR-POLYHEDROSIS-VIRUS; PURIFIED GRANULOSIS VIRUS; PIERIS-BRASSICAE; CYDIA-POMONELLA; CABBAGE-LOOPER; HELIOTHIS-ZEA; THERMAL INACTIVATION; SODIUM HYPOCHLORITE; SIMULATED SUNLIGHT; VIRUCIDAL EFFICACY AB The environmental fate of viruses is a topic of recent interest because the transport and fate of viruses in the environment may impact human and animal health. In studying the transport of pathogenic viruses in the environment some workers have used non-pathogenic surrogate or "simulant" viruses as tracer organisms for safety reasons. In an effort to identify simulants for orthopoxviruses, the use of baculoviruses has been proposed. Like poxviruses, they are also large, ds-DNA viruses. Unlike poxviruses, however, they are generally regarded as harmless to plants and animals outside their narrow insect host range and have been broadly disseminated for decades in organic agriculture as natural insecticides. The use of baculoviruses as simulants for the development of decontaminants requires an understanding of the relative resistance of both poxviruses and baculoviruses to environmental stressors, so that their relative, inherent rates of environmental degradation can be accounted for in determining whether a candidate decontamination regime is effective. To this end, we review here what is known about the susceptibility of baculoviruses and poxviruses to environmental stressors (temperature, UV light, moisture and pH) and the influence of their physical environments (soil, phyllosphere, or aquatic surroundings). C1 [Ouellette, Gary D.] US Army, SAIC, ECBC, Aberdeen Proving Ground, MD USA. [Buckley, Patricia E.; O'Connell, Kevin P.] US Army, ECBC, AMSRD ECB RT BM, Aberdeen Proving Ground, MD USA. RP Ouellette, GD (reprint author), US Army, SAIC, ECBC, Aberdeen Proving Ground, MD USA. NR 125 TC 0 Z9 0 U1 0 U2 5 PU SPRINGER PI DORDRECHT PA PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 1874-6489 BN 978-90-481-9636-4 J9 NATO SCI PEACE SEC A JI NATO Sci. Peace Secur. Ser. A-Chem. Biol. PY 2010 BP 125 EP + DI 10.1007/978-90-481-9637-1_12 PG 7 WC Biotechnology & Applied Microbiology; Chemistry, Applied; Microbiology; Virology SC Biotechnology & Applied Microbiology; Chemistry; Microbiology; Virology GA BUX82 UT WOS:000290639600012 ER PT S AU Cancio, LC AF Cancio, Leopoldo C. BE Douglass, MR Hornbeck, LJ TI Application of novel hyperspectral imaging technologies in combat casualty care SO EMERGING DIGITAL MICROMIRROR DEVICE BASED SYSTEMS AND APPLICATIONS II SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Emerging Digital Micromirror Device Based Systems and Applications II CY JAN 27, 2010 CL San Francisco, CA SP SPIE, Texas Instruments Inc ID OPERATION-ENDURING-FREEDOM; ISCHEMIA-REPERFUSION INJURY; NEAR-INFRARED SPECTROSCOPY; EN-ROUTE CARE; DAMAGE CONTROL; IRAQI-FREEDOM; MASS CASUALTIES; EARLY EXCISION; TOURNIQUET USE; BURN PATIENTS AB Novel hyperspectral imaging (HSI) methods may play several important roles in Combat Casualty Care: (1) HSI of the skin may provide spatial data on hemoglobin saturation of oxygen, as a "window" into perfusion during shock. (2) HSI or similar technology could be incorporated into closed-loop, feedback-controlled resuscitation systems. (3) HSI may provide information about tissue viability and/or wound infection. (4) HSI in the near-infrared range may provide information on the tissue water content--greatly affected, e.g., by fluid resuscitation. Thus, further refinements in the speed and size of HSI systems are sought to make these capabilities available on the battlefield. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. NR 56 TC 1 Z9 1 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-7992-1 J9 PROC SPIE PY 2010 VL 7596 AR 759605 DI 10.1117/12.846331 PG 8 WC Engineering, Biomedical; Optics SC Engineering; Optics GA BSG22 UT WOS:000284357800004 ER PT J AU Xu, K AF Xu, Kang TI Electrolytes and Interphasial Chemistry in Li Ion Devices SO ENERGIES LA English DT Review DE interphase; Li ion batteries; electrolytes ID PROPYLENE CARBONATE SOLUTIONS; LITHIUM-ION; ETHYLENE CARBONATE; SURFACE-FILMS; BATTERIES; GRAPHITE; INTERCALATION; ELECTRODES; BEHAVIOR; ANODES AB Since its appearance in 1991, the Li ion battery has been the major power source driving the rapid digitalization of our daily life; however, much of the processes and mechanisms underpinning this newest battery chemistry remains poorly understood. As in any electrochemical device, the major challenge comes from the electrolyte/electrode interfaces, where the discontinuity in charge distribution and extreme disequality in electric forces induce diversified processes that eventually determine the kinetics of Li(+) intercalation chemistry. This article will summarize the most recent efforts on the fundamental understanding of the interphases in Li ion devices. Emphasis will be placed on the formation chemistry of the so-called "SEI" on graphitic anode, the effect of solvation sheath structure of Li(+) on the intercalation energy barrier, and the feasibility of tailoring a desired interphase. Biologically inspired approaches to an ideal interphase will also be briefly discussed. C1 USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. EM cxu@arl.army.mil NR 32 TC 50 Z9 50 U1 12 U2 121 PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1996-1073 J9 ENERGIES JI Energies PD JAN PY 2010 VL 3 IS 1 BP 135 EP 154 DI 10.3390/en3010135 PG 20 WC Energy & Fuels SC Energy & Fuels GA 583UJ UT WOS:000276705100005 ER PT S AU Wood, J Klote, MM Tung, HL Stachura, ME Astapova, EV Sofge, DA Grayson, J Lawless, WF AF Wood, Joseph Klote, Mary M. Tung, Hui-Lien Stachura, Max E. Astapova, Elena V. Sofge, Donald A. Grayson, James Lawless, W. F. BE QuintelaVarajao, JE CruzCunha, MM Putnik, GD Trigo, A TI Military Medical Department Research Centers SO ENTERPRISE INFORMATION SYSTEMS PT II SE Communications in Computer and Information Science LA English DT Proceedings Paper CT International Conference on Enterprise Information Systems CY OCT 20-22, 2010 CL Viana do Castelo, PORTUGAL SP Univ TrasosMontes & Alto Douro, Polytechn Inst Cavado & Ave, GESITI DE Organizational uncertainty; metrics; interdependence AB We review our research with military Medical Department Research Centers (MDRC; a pseudonym). In 2006, we first proposed an electronic data system with metrics to better measure performance for the MDRCs. The data management system evolved into an electronic system for an Institutional Review Board (e-IRB) at one site. We foresaw that an e-IRB could provide the metrics to better monitor MDRC practices. Now that the eIRB is operational, metrics can measure how well the present mission of the MDRCs is being met across its system (improved patient care, increased scientific knowledge, and improved graduate student education); and, how well its vision is achieved (transforming the present mission of MDRCs to prepare for future missions). C1 [Lawless, W. F.] Paine Coll, 1235 15th St, Augusta, GA 30901 USA. [Wood, Joseph] Dept Clin Invest, Ft Gordon, GA 30905 USA. [Klote, Mary M.] US Army, Clin Investigat Regulatory Off, Med Res & Mat Command, Frederick, MD 21702 USA. [Tung, Hui-Lien] Dept Management, Auburn, AL USA. [Stachura, Max E.; Astapova, Elena V.] Ctr Telehlth, Med Coll Georgia, Augusta, GA USA. [Sofge, Donald A.] Navy Ctr, Appl Res Artificial Intelligence, Naval Res Lab, Washington, DC USA. [Grayson, James] Augusta State Univ, Augusta, GA 30904 USA. RP Lawless, WF (reprint author), Paine Coll, 1235 15th St, Augusta, GA 30901 USA. EM Joseph.C.Wood@us.army.mil; Mary.Klote@us.army.mil; hzt0007@auburn.edu; maxs@mcg.edu; eastapova@mail.mcg.edu; donald.sofge@nrl.navy.nil; jgrayson@aug.edu; wlawless@paine.edu FU U. S. Army Research Office [W911NF-10-1-0252] FX This material is based upon work supported by, or in part by, the U. S. Army Research Laboratory and the U. S. Army Research Office under contract/grant number W911NF-10-1-0252. NR 22 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER-VERLAG BERLIN PI BERLIN PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY SN 1865-0929 BN 978-3-642-16418-7 J9 COMM COM INF SC PY 2010 VL 110 BP 109 EP + PN 2 PG 2 WC Computer Science, Information Systems; Computer Science, Software Engineering; Computer Science, Theory & Methods SC Computer Science GA BTZ21 UT WOS:000288485400011 ER PT J AU Griggs, C Larson, S Liu, GJ Felt, D Martin, WA Thompson, M Nestler, C AF Griggs, Christopher Larson, Steven Liu, Goujing Felt, Deborah Martin, W. Andy Thompson, Michelle Nestler, Catherine TI Solid-Phase Tungsten Speciation by Differential Digestion SO ENVIRONMENTAL FORENSICS LA English DT Article DE tungsten; tungstate; tungsten trioxide; speciation; differential digestion; x-ray diffraction (XRD) ID SOIL AB In this study, a series of chemical extractions was used as a low-level, solid-phase tungsten speciation technique and correlated with XRD results. In addition to qualitative speciation, these efforts, which utilize the varying solubilities of WO(4)(-2), WO(3), and W, provide statistically representative quantitative data at environmentally relevant levels. The selective nature of the digestion procedures allowed calculation of each individual species concentration by subtracting recoveries of the composite matrices from the total tungsten determinations. The results of this method exceed the sensitivity limitations of non-destructive techniques and may provide a valuable tool in environmental forensic investigations regarding the source of tungsten contamination. C1 [Griggs, Christopher; Larson, Steven; Felt, Deborah; Martin, W. Andy] USA, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Liu, Goujing] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. [Thompson, Michelle; Nestler, Catherine] Appl Res Associates, Vicksburg, MS USA. RP Griggs, C (reprint author), USA, Environm Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM chris.s.griggs@usace.army.mil NR 17 TC 0 Z9 0 U1 3 U2 12 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 1527-5922 J9 ENVIRON FORENSICS JI Environ. Forensics PY 2010 VL 11 IS 3 BP 275 EP 281 DI 10.1080/15275922.2010.494966 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA 651BK UT WOS:000281899400009 ER PT J AU Van Aggelen, G Ankley, GT Baldwin, WS Bearden, DW Benson, WH Chipman, JK Collette, TW Craft, JA Denslow, ND Embry, MR Falciani, F George, SG Helbing, CC Hoekstra, PF Iguchi, T Kagami, Y Katsiadaki, I Kille, P Liu, L Lord, PG McIntyre, T O'Neill, A Osachoff, H Perkins, EJ Santos, EM Skirrow, RC Snape, JR Tyler, CR Versteeg, D Viant, MR Volz, DC Williams, TD Yu, L AF Van Aggelen, Graham Ankley, Gerald T. Baldwin, William S. Bearden, Daniel W. Benson, William H. Chipman, J. Kevin Collette, Tim W. Craft, John A. Denslow, Nancy D. Embry, Michael R. Falciani, Francesco George, Stephen G. Helbing, Caren C. Hoekstra, Paul F. Iguchi, Taisen Kagami, Yoshi Katsiadaki, Ioanna Kille, Peter Liu, Li Lord, Peter G. McIntyre, Terry O'Neill, Anne Osachoff, Heather Perkins, Ed J. Santos, Eduarda M. Skirrow, Rachel C. Snape, Jason R. Tyler, Charles R. Versteeg, Don Viant, Mark R. Volz, David C. Williams, Tim D. Yu, Lorraine TI Integrating Omic Technologies into Aquatic Ecological Risk Assessment and Environmental Monitoring: Hurdles, Achievements, and Future Outlook SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE environment; environmental monitoring; fish; metabolomics; microarray; regulatory toxicology; transcriptomics ID FATHEAD MINNOWS; TOXICOGENOMICS; MICROARRAY; ECOTOXICOLOGY; BIOMARKERS; RESPONSES; PROFILES; SYSTEMS; SITES AB BACKGROUND: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics-Moving into Regulation and Monitoring, held 21-23 April 2008 at the Pacific Environmental Science Centre, Vancouver, BC, Canada). OBJECTIVES: The consortium from government agencies, academia, and industry addressed three topics: progress in ecotoxicogenomics, regulatory perspectives on roadblocks for practical implementation of toxicogenomics into risk assessment, and dealing with variability in data sets. DISCUSSION: Participants noted that examples of successful application of omic technologies have been identified, but critical studies are needed to relate molecular changes to ecological adverse outcome. Participants made recommendations for the management of technical and biological variation. They also stressed the need for enhanced interdisciplinary training and communication as well as considerable investment into the generation and curation of appropriate reference omic data. CONCLUSIONS: The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach. C1 [Chipman, J. Kevin] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England. [Van Aggelen, Graham; McIntyre, Terry; Osachoff, Heather; Skirrow, Rachel C.; Yu, Lorraine] Environm Canada, Pacific Environm Sci Ctr, Vancouver, BC, Canada. [Ankley, Gerald T.] US EPA, Duluth, MN USA. [Baldwin, William S.] Clemson Univ, Clemson, SC USA. [Bearden, Daniel W.] NIST, Hollings Marine Lab, Charleston, SC USA. [Benson, William H.] US EPA, Gulf Ecol Div, Gulf Breeze, FL USA. [Collette, Tim W.] US EPA, Athens, GA USA. [Craft, John A.] Glasgow Caledonian Univ, Glasgow G4 0BA, Lanark, Scotland. [Denslow, Nancy D.; Liu, Li] Univ Florida, Gainesville, FL USA. [Embry, Michael R.] Hlth & Environm Sci Inst, Washington, DC USA. [George, Stephen G.] Univ Stirling, Stirling FK9 4LA, Scotland. [Helbing, Caren C.] Univ Victoria, Victoria, BC, Canada. [Hoekstra, Paul F.] Syngenta Crop Protect Canada Inc, Guelph, ON, Canada. [Iguchi, Taisen] Okazaki Natl Res Inst, Aichi, Japan. [Kagami, Yoshi] Ecogen Inc, Fukuoka, Japan. [Katsiadaki, Ioanna] Ctr Environm Fisheries & Aquaculture Sci, Weymouth, Dorset, England. [Kille, Peter] Cardiff Univ, Cardiff, S Glam, Wales. [Lord, Peter G.] Johnson & Johnson, New Brunswick, NJ USA. [O'Neill, Anne] Environm Agcy, Bristol, Avon, England. [Perkins, Ed J.] US Army Corps Engn, Vicksburg, MS USA. [Santos, Eduarda M.; Tyler, Charles R.] Univ Exeter, Exeter, Devon, England. [Versteeg, Don] Procter & Gamble Co, Cincinnati, OH USA. [Volz, David C.] Syngenta Crop Protect Inc, Greensboro, NC USA. RP Chipman, JK (reprint author), Univ Birmingham, Sch Biosci, Univ Rd W, Birmingham B15 2TT, W Midlands, England. EM j.k.chipman@bham.ac.uk RI Falciani, Francesco/F-3490-2010; Kille, Peter/A-4337-2010; Viant, Mark/B-6339-2009; Williams, Tim/G-1180-2010; OI Kille, Peter/0000-0001-6023-5221; Viant, Mark/0000-0001-5898-4119; Williams, Timothy/0000-0002-5857-3851; Katsiadaki, Ioanna/0000-0001-8649-2795; Santos, Eduarda/0000-0002-4074-0121 FU U.K. National Environment Research Council [NE/D000793/1] FX The workshop was funded by the U.K. National Environment Research Council (grant NE/D000793/1). NR 34 TC 62 Z9 64 U1 8 U2 97 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JAN PY 2010 VL 118 IS 1 BP 1 EP 5 DI 10.1289/ehp.0900985 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 539XP UT WOS:000273292800017 PM 20056575 ER PT J AU Johnson, DR Methner, MM Kennedy, AJ Steevens, JA AF Johnson, David R. Methner, Mark M. Kennedy, Alan J. Steevens, Jeffery A. TI Potential for Occupational Exposure to Engineered Carbon-Based Nanomaterials in Environmental Laboratory Studies SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE aerosolization; ecotoxicology; multiwalled carbon nanotubes; nanomaterials; occupational exposure; sonication ID NATURAL ORGANIC-MATTER; NANOTUBES; TOXICITY; HEALTH; OPERATIONS; ADSORPTION; PULMONARY; IMPACT; MICE AB BACKGROUND: The potential exists for laboratory personnel to be exposed to engineered carbon-based nanomaterials (CNMs) in studies aimed at producing conditions similar to those found in natural surface waters [e.g., presence of natural organic matter (NOM)]. OBJECTIVE: The goal of this preliminary investigation was to assess the release of CNMs into the laboratory atmosphere during handling and sonication into environmentally relevant matrices. METHODS: We measured fullerenes (C60), underivatized multiwalled carbon nanotubes (raw MWCNT), hydroxylated MWCNT (MWCNT-OH), and carbon black (CB) in air as the nanomaterials were weighed, transferred to beakers filled with reconstituted freshwater, and sonicated in deionized water and reconstituted freshwater with and without NOM. Airborne nanomaterials emitted during processing were quantified using two hand-held particle counters that measure total particle number concentration per volume of air within the nanometer range (10-1,000 nm) and six specific size ranges (300-10,000 nm). Particle size and morphology were determined by transmission electron microscopy of air sample filters. DISCUSSION: After correcting for background particle number concentrations, it was evident that increases in airborne particle number concentrations occurred for each nanomaterial except CB during weighing, with airborne particle number concentrations inversely related to particle size. Sonicating nanomaterial-spiked water resulted in increased airborne nanomaterials, most notably for MWCNT-OH in water with NOM and for CB. CONCLUSION: Engineered nanomaterials can become airborne when mixed in solution by sonication, especially when nanomaterials are functionalized or in water containing NOM. This finding indicates that laboratory workers may be at increased risk of exposure to engineered nanomaterials. C1 [Johnson, David R.; Kennedy, Alan J.; Steevens, Jeffery A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Methner, Mark M.] NIOSH, Nanotechnol Res Ctr, Cincinnati, OH 45226 USA. RP Johnson, DR (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd,Bldg 6011, Vicksburg, MS 39180 USA. EM David.R.Johnson@usace.army.mil FU U.S. Army Environmental Quality Technology Program FX Support was provided by the U.S. Army Environmental Quality Technology Program. Permission was granted by the Chief of Engineers to publish this information. NR 24 TC 61 Z9 61 U1 1 U2 32 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 EI 1552-9924 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD JAN PY 2010 VL 118 IS 1 BP 49 EP 54 DI 10.1289/ehp.0901076 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 539XP UT WOS:000273292800023 PM 20056572 ER PT J AU Gong, P Basu, N Scheuhammer, AM Perkins, EJ AF Gong, Ping Basu, Niladri Scheuhammer, Anton M. Perkins, Edward J. TI Neurochemical and electrophysiological diagnosis of reversible neurotoxicity in earthworms exposed to sublethal concentrations of CL-20 SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH LA English DT Article DE Conduction velocity; Earthworm (Eisenia fetida); Electrophysiological recording; Giant nerve fiber; Hexanitrohexaazaisowurtzitane (CL-20); Muscarinic acetylcholine receptor (mAChR); Reversible neurotoxicity ID EISENIA-FOETIDA; BIOCHEMICAL MARKERS; NERVOUS-SYSTEM; RECEPTORS; HEXANITROHEXAAZAISOWURTZITANE; PESTICIDES; RDX AB Hexanitrohexaazaisowurtzitane (CL-20) is a relatively new energetic compound sharing some degree of structural similarity with hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), a known neurotoxic compound. Previously, we demonstrated using a noninvasive electrophysiological technique that CL-20 was a more potent neurotoxicant than RDX to the earthworm Eisenia fetida. In the present study, we investigated the effect of CL-20 exposure and subsequent recovery on muscarinic acetylcholine receptors (mAChRs) to further define the mechanism of reversible neurotoxicity of CL-20 in E. fetida. We used a noninvasive electrophysiological technique to evaluate neurotoxicity in CL-20-treated worms, and then measured how such exposures altered levels of whole-body mAChR in the same animals. A good correlation exists between these two types of endpoints. Effect on mAChR levels was most prominent at day 6 of exposure. After 7 days of recovery, both conduction velocity and mAChR were significantly restored. Our results show that sublethal concentrations of CL-20 significantly reduced mAChR levels in a concentration- and duration-dependent manner, which was accompanied with significant decreases in the conduction velocity of the medial and lateral giant nerve fibers. After 7-day post exposure recovery, worms restored both neurochemical (mAChR) and neurophysiological (conduction velocity) endpoints that were reduced during 6-day exposures to CL-20 concentrations from 0.02 to 0.22 A mu g/cm(2). Our findings support the idea that CL-20 induced neurotoxic effects are reversible, and suggest that CL-20 neurotoxicity may be mediated through the cholinergic system. Future studies will investigate other neurotransmission systems such as GABA, glutamate, and monoamine. Ion channels in the nerve membrane should be examined to further define the precise mechanisms underlying CL-20 neurotoxicity. C1 [Gong, Ping] SpecPro Inc, Vicksburg, MS 39180 USA. [Basu, Niladri] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA. [Scheuhammer, Anton M.] Environm Canada, Canadian Wildlife Serv, Natl Wildlife Res Ctr, Ottawa, ON K1A 0H3, Canada. [Perkins, Edward J.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), SpecPro Inc, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ping.gong@us.army.mil OI Basu, Niladri/0000-0002-2695-1037 FU U.S. Army Environmental Quality Technology Basic Research Program FX This study was funded by the U.S. Army Environmental Quality Technology Basic Research Program. Permission was granted by the Chief of Engineers to publish this information. We thank Willie Brown and Robert Boyd for their technical assistance. NR 24 TC 5 Z9 5 U1 1 U2 16 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 0944-1344 EI 1614-7499 J9 ENVIRON SCI POLLUT R JI Environ. Sci. Pollut. Res. PD JAN PY 2010 VL 17 IS 1 BP 181 EP 186 DI 10.1007/s11356-009-0117-5 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 540DN UT WOS:000273311100018 PM 19274471 ER PT J AU Banasik, M Hardy, M Muro-Cacho, C Hover, CG Stedeford, T AF Banasik, Marek Hardy, Marcia Muro-Cacho, Carlos Hover, Carl G. Stedeford, Todd TI Developmental immunotoxicity and the importance of controlling for litter effects SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY LA English DT Letter DE Decabromodiphenyl ether; DBDE; BDE-209; Developmental immunotoxicity ID EXPERT WORKING GROUP; STATISTICAL ISSUES C1 [Banasik, Marek] Inst Publ Hlth & Environm Protect, PL-02835 Warsaw, Poland. [Hardy, Marcia; Stedeford, Todd] Albemarle Corp, Hlth Safety & Environm, Baton Rouge, LA 70801 USA. [Muro-Cacho, Carlos] James A Haley Vet Affairs Med Ctr, Tampa, FL 33612 USA. [Hover, Carl G.] USA, Safety Environm & Integrated Planning Off, Ft Detrick, MD 21702 USA. RP Banasik, M (reprint author), Inst Publ Hlth & Environm Protect, PL-02835 Warsaw, Poland. EM iphep.banasik@gmail.com NR 7 TC 1 Z9 1 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1382-6689 J9 ENVIRON TOXICOL PHAR JI Environ. Toxicol. Pharmacol. PD JAN PY 2010 VL 29 IS 1 BP 1 EP 2 DI 10.1016/j.etap.2009.08.003 PG 2 WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology GA 546UA UT WOS:000273837200001 PM 21787573 ER PT J AU Chen, JYC AF Chen, Jessie Y. C. TI UAV-guided navigation for ground robot tele-operation in a military reconnaissance environment SO ERGONOMICS LA English DT Article DE human-robot interaction; military; navigation; spatial ability; UAV; UGV ID SIMULATED MULTITASKING ENVIRONMENT; INDIVIDUAL-DIFFERENCES; CONCURRENT PERFORMANCE; VIRTUAL ENVIRONMENTS; TASKS; DIRECTION; DISPLAYS; STRATEGY; ABILITY; DESIGN AB A military reconnaissance environment was simulated to examine the performance of ground robotics operators who were instructed to utilise streaming video from an unmanned aerial vehicle (UAV) to navigate his/her ground robot to the locations of the targets. The effects of participants' spatial ability on their performance and workloadwere also investigated. Results showed that participants' overall performance (speed and accuracy) was better when she/he had access to images from larger UAVs with fixed orientations, compared with other UAV conditions (baseline- no UAV, micro air vehicle and UAV with orbiting views). Participants experienced the highest workload when the UAV was orbiting. Those individuals with higher spatial ability performed significantly better and reported less workload than those with lower spatial ability. The results of the current study will further understanding of ground robot operators' target search performance based on streaming video from UAVs. The results will also facilitate the implementation of ground/air robots in military environments and will be useful to the future military system design and training community. C1 USA, Res Lab, Human Res & Engn Directorate, Orlando, FL USA. RP Chen, JYC (reprint author), USA, Res Lab, Human Res & Engn Directorate, Orlando, FL USA. EM jessie.chen@us.army.mil FU US Army's Robotics Collaboration Army Technology Objective (ATO); RDECOM Simulation & Training Technology Center (STTC) FX This project was funded by the US Army's Robotics Collaboration Army Technology Objective (ATO) and Scalable Embedded Training - Mission Rehearsal ATO of RDECOM Simulation & Training Technology Center (STTC). The author wishes to thank Mr Bryan Clark for his contribution to the data collection process and Mr Michael Barnes of ARL-HRED for his guidance. The author would also like to thank STTC for providing equipment and support. NR 41 TC 19 Z9 21 U1 3 U2 14 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0014-0139 J9 ERGONOMICS JI Ergonomics PY 2010 VL 53 IS 8 BP 940 EP 950 AR PII 924714190 DI 10.1080/00140139.2010.500404 PG 11 WC Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Engineering; Psychology GA 630IK UT WOS:000280266400002 PM 20658388 ER PT J AU Gregorczyk, KN Hasselquist, L Schiffman, JM Bensel, CK Obusek, JP Gutekunst, DJ AF Gregorczyk, Karen N. Hasselquist, Leif Schiffman, Jeffrey M. Bensel, Carolyn K. Obusek, John P. Gutekunst, David J. TI Effects of a lower-body exoskeleton device on metabolic cost and gait biomechanics during load carriage SO ERGONOMICS LA English DT Article DE backpack loads; exoskeleton; gait biomechanics; load carriage; metabolic cost ID PROLONGED TREADMILL WALKING; ENERGY-COST; PHYSIOLOGICAL-RESPONSES; LEG EXOSKELETON; LEVEL WALKING; WOMEN; MASS; BACKPACKING; EXPENDITURE; CHALLENGES AB This study investigated the effects on metabolic cost and gait biomechanics of using a prototype lower-body exoskeleton (EXO) to carry loads. Nine US Army participants walked at 1.34m/s on a 0% grade for 8min carrying military loads of 20kg, 40kg and 55kg with and without the EXO. Mean oxygen consumption (VO2) scaled to body mass and scaled to total mass were significantly higher, by 60% and 41% respectively, when the EXO was worn, compared with the control condition. Mean V 8,500 hours at FCE. Electrochemical Hydrogen Separation (EHS) systems, currently under development at FCE, can separate the excess hydrogen produced in the DFC (R) system with relatively lower energy consumption. C1 [Patel, P.; Lipp, L.; Jahnke, F.] FuelCell Energy Inc FCE, Danbury, CT 06813 USA. [Heydorn, E.] Air Prod & Chem Inc, Allentown, PA 18195 USA. [Abdallah, T.; Holcomb, F.] S Army Engn Res & Dev Ctr, ERDC, CERL, Champaign, IL 61822 USA. RP Patel, P (reprint author), FuelCell Energy Inc FCE, Danbury, CT 06813 USA. FU ERDC-CERL; Connecticut Clean Energy Fund; DOE-EERE; APCI; FCE FX Financial support from ERDC-CERL, Connecticut Clean Energy Fund, DOE-EERE, APCI and FCE is gratefully acknowledged. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 65 S MAIN ST, PENNINGTON, NJ 08534-2839 USA SN 1938-5862 BN 978-1-60768-166-3 J9 ECS TRANSACTIONS PY 2010 VL 26 IS 1 BP 493 EP 504 DI 10.1149/1.3429022 PG 12 WC Electrochemistry; Energy & Fuels SC Electrochemistry; Energy & Fuels GA BDI60 UT WOS:000313482800051 ER PT J AU Ryan, K AF Ryan, Kevin BE Bellacqua, J TI Russo-Chinese Defense Relations The View from Moscow SO FUTURE OF CHINA-RUSSIA RELATIONS SE Asia in the New Millennium LA English DT Article; Book Chapter C1 [Ryan, Kevin] Harvards Belfer Ctr Sci & Int Affairs, Cambridge, MA 02138 USA. [Ryan, Kevin] Off Secretary Def, Washington, DC USA. [Ryan, Kevin] US POW MIA Off Moscow, Moscow, Russia. [Ryan, Kevin] Armys Space, Huntsville, AL USA. [Ryan, Kevin] Missile Def Command, Huntsville, AL USA. [Ryan, Kevin] US Mil Acad, West Point, NY USA. [Ryan, Kevin] Armys Directorate Strategy Plans & Policy, Goldsboro, NC USA. RP Ryan, K (reprint author), Harvards Belfer Ctr Sci & Int Affairs, Cambridge, MA 02138 USA. NR 53 TC 1 Z9 1 U1 0 U2 0 PU UNIV PRESS KENTUCKY PI LEXINGTON PA 102 LAFFERTY HALL, UNIVERSITY OF KENTUCKY, LEXINGTON, KY 40506 USA BN 978-0-8131-2939-6 J9 ASIA NEW MILLENN PY 2010 BP 179 EP 202 PG 24 WC International Relations SC International Relations GA BAJ86 UT WOS:000304375000007 ER PT J AU Stiehm, JH AF Stiehm, Judith Hicks BE Sjoberg, L TI Theses on the military, security, war and women SO GENDER AND INTERNATIONAL SECURITY: FEMINIST PERSPECTIVES SE Routledge Critical Security Studies LA English DT Article; Book Chapter C1 [Stiehm, Judith Hicks] Florida Int Univ, Miami, FL 33199 USA. [Stiehm, Judith Hicks] Univ Wisconsin, Madison, WI 53706 USA. [Stiehm, Judith Hicks] Univ Calif Los Angeles, Los Angeles, CA 90024 USA. [Stiehm, Judith Hicks] Univ So Calif, Los Angeles, CA 90089 USA. RP Stiehm, JH (reprint author), USA, Peacekeeping Inst, Washington, DC 20310 USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON EC4P 4EE, ENGLAND BN 978-0-203-86693-1 J9 ROUTL CRIT SECUR STU PY 2010 BP 17 EP 23 PG 7 WC Political Science; Women's Studies SC Government & Law; Women's Studies GA BNB66 UT WOS:000274092000002 ER PT J AU Losada, L Ronning, CM DeShazer, D Woods, D Fedorova, N Kim, HS Shabalina, SA Pearson, TR Brinkac, L Tan, P Nandi, T Crabtree, J Badger, J Beckstrom-Sternberg, S Saqib, M Schutzer, SE Keim, P Nierman, WC AF Losada, Liliana Ronning, Catherine M. DeShazer, David Woods, Donald Fedorova, Natalie Kim, H. Stanley Shabalina, Svetlana A. Pearson, Talima R. Brinkac, Lauren Tan, Patrick Nandi, Tannistha Crabtree, Jonathan Badger, Jonathan Beckstrom-Sternberg, Steve Saqib, Muhammad Schutzer, Steven E. Keim, Paul Nierman, William C. TI Continuing Evolution of Burkholderia mallei Through Genome Reduction and Large-Scale Rearrangements SO GENOME BIOLOGY AND EVOLUTION LA English DT Article DE bacterial evolution; comparative genomics; genome erosion; bacterial virulence ID MICROBIAL GENE IDENTIFICATION; BACTERIAL GENOMES; PSEUDOMALLEI; MELIOIDOSIS; AGENT; SALMONELLA; CHROMOSOME; AMINOGLYCOSIDE; SUSCEPTIBILITY; POPULATIONS AB Burkholderia mallei (Bm), the causative agent of the predominately equine disease glanders, is a genetically uniform species that is very closely related to the much more diverse species Burkholderia pseudomallei (Bp), an opportunistic human pathogen and the primary cause of melioidosis. To gain insight into the relative lack of genetic diversity within Bm, we performed whole-genome comparative analysis of seven Bm strains and contrasted these with eight Bp strains. The Bm core genome (shared by all seven strains) is smaller in size than that of Bp, but the inverse is true for the variable gene sets that are distributed across strains. Interestingly, the biological roles of the Bm variable gene sets are much more homogeneous than those of Bp. The Bm variable genes are found mostly in contiguous regions flanked by insertion sequence (IS) elements, which appear to mediate excision and subsequent elimination of groups of genes that are under reduced selection in the mammalian host. The analysis suggests that the Bm genome continues to evolve through random IS-mediated recombination events, and differences in gene content may contribute to differences in virulence observed among Bm strains. The results are consistent with the view that Bm recently evolved from a single strain of Bp upon introduction into an animal host followed by expansion of IS elements, prophage elimination, and genome rearrangements and reduction mediated by homologous recombination across IS elements. C1 [Losada, Liliana; Ronning, Catherine M.; Fedorova, Natalie; Brinkac, Lauren; Nierman, William C.] J Craig Venter Inst, Rockville, MD USA. [Losada, Liliana] Trinity Univ, Washington, DC USA. [DeShazer, David] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Woods, Donald] Univ Calgary, Dept Microbiol & Infect Dis, Calgary, AB, Canada. [Kim, H. Stanley] Korea Univ, Coll Med, Bioinformat & Funct Genom Lab, Seoul 136705, South Korea. [Shabalina, Svetlana A.] NIH, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA. [Pearson, Talima R.; Beckstrom-Sternberg, Steve; Keim, Paul] No Arizona Univ, Ctr Microbial Genet & Genom, Flagstaff, AZ 86011 USA. [Tan, Patrick; Nandi, Tannistha] Genome Inst Singapore, Singapore, Singapore. [Tan, Patrick] Duke Natl Univ Singapore, Grad Sch Med, Durham, NC USA. [Crabtree, Jonathan] Univ Maryland Baltimore Cty, Bioinformat Resource Ctr, Baltimore, MD 21228 USA. [Crabtree, Jonathan] J Craig Venter Inst, San Diego, CA USA. [Saqib, Muhammad] Vet Res Ctr, Barka, Oman. [Saqib, Muhammad] Univ Agr Faisalabad, Faisalabad, Pakistan. [Schutzer, Steven E.] Univ Med & Dent New Jersey, Dept Med, Sch Med, Newark, NJ 07103 USA. [Nierman, William C.] George Washington Univ, Dept Biochem & Mol Biol, Sch Med, Washington, DC 20052 USA. RP Losada, L (reprint author), J Craig Venter Inst, Rockville, MD USA. EM llosada@jcvi.org RI Keim, Paul/A-2269-2010; Shabalina, Svetlana/N-8939-2013; Abrams, Natalie/F-4845-2011 OI Shabalina, Svetlana/0000-0003-2272-7473; Abrams, Natalie/0000-0001-9698-2819 FU National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [N01-AI-30071] FX This project has been funded with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under contract number N01-AI-30071. NR 53 TC 30 Z9 31 U1 6 U2 14 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 1759-6653 J9 GENOME BIOL EVOL JI Genome Biol. Evol. PY 2010 VL 2 BP 102 EP 116 DI 10.1093/gbe/evq003 PG 15 WC Evolutionary Biology; Genetics & Heredity SC Evolutionary Biology; Genetics & Heredity GA 633DP UT WOS:000280480000010 PM 20333227 ER PT J AU McKenna, SP McKenna, JR AF McKenna, Sean P. McKenna, Jason R. TI Modeling and analysis of the response of a triaxial, frequency-domain electromagnetic induction sensor to a buried linear conductor SO GEOPHYSICS LA English DT Article DE electric sensing devices; electromagnetic induction; geomagnetism; geophysical signal processing; geotechnical engineering; object detection; terrestrial electricity; tunnels ID CABLE; MULTICOMPONENT; EXCITATION; OBJECTS; PLANE; SITE AB This paper presents analytical modeling results for a triaxial frequency-domain electromagnetic-induction (EMI) sensor over a homogeneous earth containing a long linear conductor. Although the conductor studied is intended to represent an underground wire or pipe, it can represent any subsurface, linear geologic structure that can channel current. Treating the sensor transmitter as a vertical magnetic dipole, the model combines the well-known solution for the magnetic field arising from the interaction with the earth with the solution for the induced magnetic field from the excited subsurface conductor. Expressions for the three components of the magnetic field at an arbitrary point above the earth are presented. Two types of coupled, moving transmitter-receiver configurations (coaxial and coplanar) wereconsidered, and the model is sufficiently flexible to allow for many other sensor variations to be studied. Characteristics of the sensor signals were explored through several parametric modeling studies that demonstrate the sensitivity of the signals to transmitter frequency, earth conductivity, conductor depth, sensor geometry, and crossing angle. Using simple relationships developed from analysis of the sensor signals, key parameters such as conductor depth and orientation can be estimated. The ability of the model to predict and characterize sensor output should prove helpful in distinguishing between geologic features and man-made underground infrastructure. These modeling results also are expected to facilitate frequency-domain EMI data analysis and interpretation, sensor design and operation, and the development of detection and classification algorithms. C1 [McKenna, Sean P.] Northrop Grumman Informat Syst, Andover, MA USA. [McKenna, Jason R.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. RP McKenna, SP (reprint author), Northrop Grumman Informat Syst, Andover, MA USA. EM sean.mckenna@ngc.com; Jason.R.McKenna@usace.army.mil FU U.S. Army Engineer Research and Development Center (ERDC) FX Funding for this research was provided by the U.S. Army Engineer Research and Development Center (ERDC) under the Near-Surface Phenomenology Military Engineering Program. The director of the ERDC's Geotechnical and Structures Laboratory granted permission to publish. NR 33 TC 7 Z9 7 U1 4 U2 4 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 USA SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD JAN-FEB PY 2010 VL 75 IS 1 BP F1 EP F14 DI 10.1190/1.3267876 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 564WD UT WOS:000275247900013 ER PT S AU Hendricks, M Merlo, J Puryear, J Smith, J AF Hendricks, Michael Merlo, James Puryear, John Smith, Justin GP ISPRS TI GEOVISUALIZATION OF PLANNED AND EXECUTED ROUTES FOR LAND NAVIGATION TRAINING WITH PEN BASED AND GPS TECHNOLOGY SO GEOSPATIAL DATA AND GEOVISUALIZATION: ENVIRONMENT, SECURITY, AND SOCIETY SE International Archives of the Photogrammetry Remote Sensing and Spatial Information Sciences LA English DT Proceedings Paper CT Joint Symposium of ISPRS Commission IV / AutoCarto Annual Conference CY NOV 15-19, 2010 CL Orlando, FL SP Int Soc Photogrammetry & Remote Sensing DE Land Navigation; GPS; Digital Pen AB Training individuals in land navigation is a challenging endeavor. One of the difficulties with this task is providing effective after action review feedback to individuals. The current method asks the navigator to draw their planned and executed route on a map. With this information the trainer provides feedback to the individual on route selection and overall success. This process is flawed in many ways. The individual often does know where they traveled, or worse they may confidently believe they traveled along a route which is in fact not true. GPS data loggers can be employed to provide the navigator feedback on their actual traveled route. Trainers can view this route information and provide quick and effective feedback related to their executed route. This technique is employed to great success with the United States Military Academy's Orienteering Team and many other individuals. Feedback on a navigator's executed route, though critical, is only part of a robust land navigation training program. It is also important to provide feedback on both the navigator's planned route and perceived executed route. Analyzing differenced between these three routes, planned, perceived, and executed, allows trainers to provide truly effective feedback. The use of geospatially referenced pen based graphic input devices allows trainers to quickly obtain both the navigator's planned route and their perceived route. These devices now allow individuals to draw their routes along with key decisions points on a paper map and have these routes automatically georeferenced. With this new technique trainers now immediately provide feedback to navigators on all three routes overlayed on high resolution imagery and map data in an interactive 3D environment. C1 [Hendricks, Michael; Merlo, James; Puryear, John; Smith, Justin] US Mil Acad, West Point, NY 10996 USA. RP Hendricks, M (reprint author), US Mil Acad, West Point, NY 10996 USA. EM michael.hendricks@usma.edu; james.merlo@usma.edu; john.puryear@usma.edu; justin.smith@usma.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU COPERNICUS GESELLSCHAFT MBH PI GOTTINGEN PA BAHNHOFSALLE 1E, GOTTINGEN, 37081, GERMANY SN 2194-9034 J9 INT ARCH PHOTOGRAMM PY 2010 VL 38 PN 4 PG 6 WC Geography, Physical; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Remote Sensing; Imaging Science & Photographic Technology GA BE1RS UT WOS:000368436900032 ER PT J AU Petraeus, GD AF Petraeus, General David TI Counterinsurgency Concepts: What We Learned in Iraq SO GLOBAL POLICY LA English DT Editorial Material C1 USA, Washington, DC USA. RP Petraeus, GD (reprint author), USA, Washington, DC USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1758-5880 J9 GLOB POLICY JI Glob. Policy PD JAN PY 2010 VL 1 IS 1 BP 116 EP 117 DI 10.1111/j.1758-5899.2009.00003.x PG 2 WC International Relations; Political Science SC International Relations; Government & Law GA V26ZC UT WOS:000208582500012 ER PT S AU Arnas, AO AF Arnas, A. Oezer BE Dincer, I Midilli, A Hepbasli, A Karakoc, TH TI On the Principles of Thermodynamics - Effects on the Environment, Global Warming, and Sustainability SO GLOBAL WARMING: ENGINEERING SOLUTIONS SE Green Energy and Technology LA English DT Proceedings Paper CT Global Conference on Global Warming CY JUL 06-10, 2008 CL Istanbul, TURKEY C1 US Mil Acad, West Point, NY 10996 USA. RP Arnas, AO (reprint author), US Mil Acad, West Point, NY 10996 USA. RI Dincer, Ibrahim/A-5379-2012 NR 12 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SN 1865-3529 BN 978-1-4419-1016-5 J9 GREEN ENERGY TECHNOL PY 2010 BP 47 EP 69 DI 10.1007/978-1-4419-1017-2_2 PG 23 WC Engineering, Mechanical SC Engineering GA BRE21 UT WOS:000282475000002 ER PT B AU Bulatov, D Lavery, J AF Bulatov, Dimitri Lavery, John BE Richards, P Braz, J Hilton, A TI COMPARISON IN THE HAUSDORFF METRIC OF RECONSTRUCTION OF 3D URBAN TERRAIN BY FOUR PROCEDURES SO GRAPP 2010: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON COMPUTER GRAPHICS THEORY AND APPLICATIONS LA English DT Proceedings Paper CT 5th International Conference on Computer Graphics Theory and Applications (GRAPP 2010) CY MAY 17-21, 2010 CL Univ Angers, Angers, FRANCE SP Inst Syst & Technol Informat Control & Commun, Workflow Management Coalit, Univ Angers, IstiA, LISA HO Univ Angers DE 3D; Alpha shapes; Cubic spline; Hausdorff distance; Irregular data; Iso-surface; L-1 spline AB We computationally compare four procedures, namely, alpha-shapes, iso-surface extraction, gridfit and L-1 splines for geometric reconstruction of 3D urban structures represented by irregular point clouds with abrupt changes in density. For significant numbers of outliers, L-1 splines produce the most accurate reconstructions both visually and when measured analytically in the Hausdorff metric but are more computationally expensive than the other three procedures. C1 [Bulatov, Dimitri] Fraunhofer Inst Optron Syst Technol & Image Explo, Gutleuthausstr 1, D-76275 Ettlingen, Germany. [Lavery, John] Army Res Lab, Div Math, Res Triangle Pk, NC 27709 USA. RP Bulatov, D (reprint author), Fraunhofer Inst Optron Syst Technol & Image Explo, Gutleuthausstr 1, D-76275 Ettlingen, Germany. EM bulatov@fom.fgan.de; john.lavery2@us.army.mil NR 20 TC 0 Z9 0 U1 0 U2 0 PU INSTICC-INST SYST TECHNOLOGIES INFORMATION CONTROL & COMMUNICATION PI SETUBAL PA AVENIDA D MANUEL L, 27A 2 ESQUERDO, SETUBAL, 2910-595, PORTUGAL BN 978-989-674-026-9 PY 2010 BP 125 EP 129 PG 5 WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic SC Computer Science; Engineering GA BG9AD UT WOS:000392907500020 ER PT B AU Paik, HJ Venkateswara, KY Moody, MV Prieto, V AF Paik, Ho Jung Venkateswara, Krishna Y. Moody, M. Vol Prieto, Violeta BE Luo, J Zhou, ZB Yeh, HC Hsu, JP TI CRYOGENIC TEST OF THE GRAVITATIONAL INVERSE-SQUARE LAW SO GRAVITATION AND ASTROPHYSICS LA English DT Proceedings Paper CT 9th Asia-Pacific International Conference on Gravitation and Astrophysics CY JUN 29-JUL 02, 2009 CL Huazhong Univ Sci & Technol, Wuhan, PEOPLES R CHINA SP Asia Pacific Ctr Theoret Phys, Natl Nat Sci Fdn China, Minist Educ P R China, Univ Massachusetts, Dartmouth Fdn HO Huazhong Univ Sci & Technol DE Test of gravity; Cryogenic; Superconducting accelerometer; ICGA 09 ID SUPERCONDUCTING GRAVITY GRADIOMETER; DIMENSIONS; MILLIMETER; FORCES AB In string theories, the law of gravity changes as the distance r is reduced to below the radius of compactification, R. Gravity-only large extra dimensions with R similar to 100 mu m could solve the gauge hierarchy problem in grand unification. On the other hand, the observed accelerating expansion of the universe is consistent with a vacuum-energy density 10(120) times smaller than the value predicted from the quantum corrections to it. This enormous discrepancy could be eliminated if gravitons were 'fat' with the size of the order of 50 mu m. Both of these possibilities would lead to a violation of the 1/r(2) law below 100 mu m. We are conducting a sub-millimeter test of the 1/r(2) law at 4.2 K. To minimize Newtonian errors, the experiment employs a near-null source, a circular disk of large diameter-to-thickness ratio. Two test masses, also disk-shaped, are positioned on the two sides of the source mass at a nominal distance of 260 mu m. The test masses are connected to a SQUID to form a superconducting differential accelerometer. As the source is driven sinusoidally, a violation signal should appear at the second harmonic due to symmetry. The detector is rigidly mounted on the housing and the source mass is suspended separately and driven from outside the housing. The source is driven at its resonance frequency. In this paper, we discuss the design, principle, and progress of this experiment. C1 [Paik, Ho Jung; Venkateswara, Krishna Y.; Moody, M. Vol] Univ Maryland, Dept Phys, College Pk, MD 20742 USA. [Prieto, Violeta] US Army, Res Lab, Adelphi, MD 20789 USA. RP Paik, HJ (reprint author), Univ Maryland, Dept Phys, College Pk, MD 20742 USA. EM hpaik@umd.edu; violeta.prieto@us.army.mil FU National Science Foundation [PHY0244966, PHY0904614] FX This research was supported in part by the National Science Foundation under grants PHY0244966 and PHY0904614. NR 14 TC 0 Z9 0 U1 0 U2 0 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA PO BOX 128 FARRER RD, SINGAPORE 9128, SINGAPORE BN 978-981-4307-66-6 PY 2010 BP 26 EP + DI 10.1142/9789814307673_0003 PG 3 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA BDB15 UT WOS:000312423200003 ER PT S AU Kolodny, MA AF Kolodny, Michael A. BE Kolodny, MA TI Introduction SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE C1 USA, Res Lab, Washington, DC 20310 USA. RP Kolodny, MA (reprint author), USA, Res Lab, Washington, DC 20310 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7694 BP XI EP XI PG 1 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900001 ER PT S AU Damarla, T AF Damarla, Thyagaraju BE Kolodny, MA TI Sensor Fusion for ISR Assets SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE Sensor fusion; Dempster-Shafer; ISR; multi-modal sensors AB Multiple sensors with multiple modalities are being routinely deployed in forward areas to gain the situational awareness. Some of the sensors are activity detection sensors such as acoustic, seismic, passive infrared (PIR), and magnetic sensors which normally consume low power. These sensors often cue or wake up more power hungry sensors such as imaging sensors, namely visible camera and infrared camera, and radar to either capture a picture or to track a target of interest. Several airborne sensors routinely gather information on an area of interest using radar, imaging sensors for intelligence, surveillance and reconnaissance (ISR) purposes. Recently, Empire Challenge has brought a new concept: that is, harvesting the ISR data from the remotely distributed unattended ground sensors. Here aerial vehicle flies by the area occasionally and queries if the sensors have any data to be harvested. Harvesting large amounts of data is unnecessary and impractical - so some amount of fusion of the sensor data is essential. C1 USA, Res Lab, ATTN RDRL SES A, Adelphi, MD 20783 USA. RP Damarla, T (reprint author), USA, Res Lab, ATTN RDRL SES A, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM thyagaraju.damarla@us.army.mil NR 9 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 PROC SPIE PY 2010 VL 7694 AR 76941C DI 10.1117/12.851700 PG 7 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900034 ER PT S AU Sadler, L Alexander, TA AF Sadler, Laurel Alexander, Troy A. BE Kolodny, MA TI Mobile Optical Detection System for Counter-Surveillance SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE Optical; Retro-reflector; Counter-Surveillance; laser diodes AB There exists a current need to rapidly and accurately identify the presence and location of optical imaging devices used in counter-surveillance activities against U. S. troops deployed abroad. The locations of devices employed in counter-surveillance activities can be identified through detection of the optically augmented reflection from these devices. To address this need, we have developed a novel optical augmentation sensor, the Mobile Optical Detection System (MODS), which is uniquely designed to identify the presence of optical systems of interest. The essential components of the sensor are three, spectrally diverse diode lasers (1 ultraviolet/2 near-infrared) which are integrated to produce a single multi-wavelength interrogation beam and a charge-coupled-device (CCD) receiver which is used to detect the retroreflected, optical beam returned from a target of interest. The multi-spectral diode laser illuminator and digital receiver are configured in a pseudo-monostatic arrangement and are controlled through a customized computer interface. By comparison, MODS is unique among OA sensors since it employs a collection of wavelength-diverse, continuous-wave (CW) diode laser sources which facilitate the identification of optical imaging devices used for counter-surveillance activities. In addition, digital image processing techniques are leveraged to facilitate improved clutter rejection concomitant with highly-specific target location (e. g., azimuth and elevation). More, the digital output format makes the sensor amenable to a wide range of interface options including computer networks, eyepieces and remotely-located displays linked through wireless nodes. C1 [Sadler, Laurel] USA, Res Lab, RDRL CII A, Adelphi, MD 20783 USA. RP Sadler, L (reprint author), USA, Res Lab, RDRL CII A, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 5 TC 2 Z9 2 U1 0 U2 1 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7694 AR 76940Y DI 10.1117/12.850465 PG 8 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900024 ER PT S AU Stolovy, GH AF Stolovy, Gary H. BE Kolodny, MA TI Standards and protocols for interoperation of unattended ground sensors SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE Unattended Ground Sensors AB Unattended Ground Sensor (UGS) systems have special requirements for long-duration, low-power operation, exfiltration of sensor reports and imagery over intermittent terrestrial or satellite communications channels, sensor description, management, discovery, configuration and command-and-control. This paper surveys a number existing and proposed software architectures for networked sensors, to include publish/subscribe brokered frameworks, with respect to the specific features needed for standards and protocols for UGS interoperability. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Stolovy, GH (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7694 AR 76940M DI 10.1117/12.851864 PG 6 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900014 ER PT S AU Stump, EA Sadler, BM AF Stump, Ethan A. Sadler, Brian M. BE Kolodny, MA TI Persistent Surveillance using Mutually-Visible Robotic Formations SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE robotic formation; mutual visibility; surveillance; collaboration AB We consider the problem of deploying mobile robots to create a mutually-visible formation between stationary and mobile targets in a known environment. A mutually-visible formation is a placement where each agent or target is connected to all others through a sequence of visibility pairings. Mutual visibility enhances radio communications links, and enables other modalities such as optical communications. We discretize the environment in a manner conducive to visibility calculations, and, as targets shift, we use dynamic programming to find formations that preserve the visibility topology and minimize movement. C1 [Stump, Ethan A.; Sadler, Brian M.] USA, Res Lab, Adelphi, MD 20783 USA. RP Stump, EA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ethan.stump@us.army.mil; bsadler@arl.army.mil NR 17 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 PROC SPIE PY 2010 VL 7694 AR 76940C DI 10.1117/12.851148 PG 9 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900008 ER PT S AU Vecherin, SN Wilson, DK Pettit, CL AF Vecherin, Sergey N. Wilson, D. Keith Pettit, Chris L. BE Kolodny, MA TI Optimal placement of multiple types of communicating sensors with availability and coverage redundancy constraints SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE sensor placement; optimization; binary linear programming; sensor communication; backup coverage; sensor availability AB Determination of an optimal configuration (numbers, types, and locations) of a sensor network is an important practical problem. In most applications, complex signal propagation effects and inhomogeneous coverage preferences lead to an optimal solution that is highly irregular and nonintuitive. The general optimization problem can be strictly formulated as a binary linear programming problem. Due to the combinatorial nature of this problem, however, its strict solution requires significant computational resources (NP-complete class of complexity) and is unobtainable for large spatial grids of candidate sensor locations. For this reason, a greedy algorithm for approximate solution was recently introduced [S. N. Vecherin, D. K. Wilson, and C. L. Pettit, "Optimal sensor placement with terrain-based constraints and signal propagation effects," Unattended Ground, Sea, and Air Sensor Technologies and Applications XI, SPIE Proc. Vol. 7333, paper 73330S (2009)]. Here further extensions to the developed algorithm are presented to include such practical needs and constraints as sensor availability, coverage by multiple sensors, and wireless communication of the sensor information. Both communication and detection are considered in a probabilistic framework. Communication signal and signature propagation effects are taken into account when calculating probabilities of communication and detection. Comparison of approximate and strict solutions on reduced-size problems suggests that the approximate algorithm yields quick and good solutions, which thus justifies using that algorithm for full-size problems. Examples of three-dimensional outdoor sensor placement are provided using a terrain-based software analysis tool. C1 [Vecherin, Sergey N.; Wilson, D. Keith] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Vecherin, SN (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM Sergey.N.Vecherin@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 6 TC 1 Z9 1 U1 1 U2 5 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 PROC SPIE PY 2010 VL 7694 AR 76940U DI 10.1117/12.849327 PG 10 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900020 ER PT S AU Wikner, DA Viveiros, EA Wellman, R Clark, J Kurtz, J Pulskamp, J Proie, R Ivanov, T Polcawich, RG Adler, ED AF Wikner, David A. Viveiros, Edward A. Wellman, Ronald Clark, John Kurtz, Jim Pulskamp, Jeff Proie, Robert Ivanov, Tony Polcawich, Ronald G. Adler, Eric D. BE Kolodny, MA TI Compact networked radars for Army unattended ground sensors SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE compact radar; unattended radar; networked radar AB The Army Research Laboratory is in partnership with the University of Florida - Electronics Communications Laboratory to develop compact radar technology and demonstrate that it is scalable to a variety of ultra-lightweight platforms (< 10 lbs.) to meet Army mission needs in persistent surveillance, unattended ground sensor (UGS), unmanned systems, and man-portable sensor applications. The advantage of this compact radar is its steerable beam technology and relatively long-range capability compared to other small, battery-powered radar concepts. This paper will review the ongoing development of the sensor and presents a sample of the collected data thus far. C1 [Wikner, David A.; Viveiros, Edward A.; Clark, John; Pulskamp, Jeff; Polcawich, Ronald G.; Adler, Eric D.] USA, Res Lab, Adelphi, MD 20783 USA. RP Wikner, DA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 6 TC 1 Z9 1 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 PROC SPIE PY 2010 VL 7694 AR 769410 DI 10.1117/12.852916 PG 10 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900026 ER PT S AU Yamamoto, KK Wilson, DK AF Yamamoto, Kenneth K. Wilson, D. Keith BE Kolodny, MA TI Environmental awareness for sensor and emitter employment SO GROUND/AIR MULTI-SENSOR INTEROPERABILITY, INTEGRATION, AND NETWORKING FOR PERSISTENT ISR SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Ground/Air Multi-Sensor Interoperability, Integration, and Networking for Persistent ISR CY APR 06-09, 2010 CL Orlando, FL SP SPIE DE battlespace signal modeling; environmental effects; battlespace command and control (C2); decision-support tool; object-oriented programming ID PROPAGATION; SOUND AB Environmental Awareness for Sensor and Emitter Employment (EASEE) is a flexible, object-oriented software design for predicting environmental effects on the performance of battlefield sensors and detectability of signal emitters. Its decision-support framework facilitates many sensor and emitter modalities and can be incorporated into battlespace command and control (C2) systems. Other potential applications include immersive simulation, force-on-force simulation, and virtual prototyping of sensor systems and signal-processing algorithms. By identifying and encoding common characteristics of Army problems involving multimodal signal transmission and sensing into a flexible software architecture in the Java programming language, EASEE seeks to provide an application interface enabling rapid integration of diverse signal-generation, propagation, and sensor models that can be implemented in many client-server environments. Its explicit probabilistic modeling of signals, systematic consideration of many complex environmental and mission-related factors affecting signal generation and propagation, and computation of statistical metrics characterizing sensor performance facilitate a highly flexible approach to signal modeling and simulation. EASEE aims to integrate many disparate statistical formulations for modeling and processing many types of signals, including infrared, acoustic, seismic, radiofrequency, and chemical/biological. EASEE includes objects for representing sensor data, inferences for target detection and/or direction, signal transmission and processing, and state information (such as time and place). Various transmission and processing objects are further grouped into platform objects, which fuse data to make various probabilistic predictions of interest. Objects representing atmospheric and terrain environments with varying degrees of fidelity enable modeling of signal generation and propagation in diverse and complex environments. C1 [Yamamoto, Kenneth K.; Wilson, D. Keith] USA, Cold Reg Res & Engn Lab, Signature Phys Branch, Hanover, NH 03755 USA. RP Wilson, DK (reprint author), USA, Cold Reg Res & Engn Lab, Signature Phys Branch, 72 Lyme Rd, Hanover, NH 03755 USA. EM D.Keith.Wilson@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 9 TC 1 Z9 1 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8158-0 J9 P SOC PHOTO-OPT INS PY 2010 VL 7694 AR 76940F DI 10.1117/12.852423 PG 9 WC Computer Science, Hardware & Architecture; Remote Sensing; Optics SC Computer Science; Remote Sensing; Optics GA BSS81 UT WOS:000285716900011 ER PT J AU Serichantalergs, O Pootong, P Dalsgaard, A Bodhidatta, L Guerry, P Tribble, DR Anuras, S Mason, CJ AF Serichantalergs, Oralak Pootong, Piyarat Dalsgaard, Anders Bodhidatta, Ladaporn Guerry, Patricia Tribble, David R. Anuras, Sinn Mason, Carl J. TI PFGE, Lior serotype, and antimicrobial resistance patterns among Campylobacter jejuni isolated from travelers and US military personnel with acute diarrhea in Thailand, 1998-2003 SO GUT PATHOGENS LA English DT Article AB Background: Campylobacter jejuni is a major cause of gastroenteritis worldwide. In Thailand, several strains of C. jejuni have been isolated and identified as major diarrheal pathogens among adult travelers. To study the epidemiology of C. jejuni in adult travelers and U. S. military personnel with acute diarrhea in Thailand from 1998-2003, strains of C. jejuni were isolated and phenotypically identified, serotyped, tested for antimicrobial susceptibility, and characterized using pulsed-field gel electrophoresis (PFGE). Results: A total of 312 C. jejuni isolates were obtained from travelers (n = 46) and U. S. military personnel (n = 266) in Thailand who were experiencing acute diarrhea. Nalidixic acid and ciprofloxacin resistance was observed in 94.9% and 93.0% of the isolates, respectively. From 2001-2003, resistance to tetracycline (81.9%), trimethoprim-sulfamethoxazole (57.9%), ampicillin (28.9%), kanamycin (5.9%), sulfisoxazole (3.9%), neomycin (2.0%), and streptomycin (0.7%) was observed. Combined PFGE analysis showed considerable genetic diversity among the C. jejuni isolates; however, four PFGE clusters included isolates from the major Lior serotypes (HL: 36, HL: 11, HL: 5, and HL: 28). The PFGE analysis linked individual C. jejuni clones that were obtained at U. S. military exercises with specific antimicrobial resistance patterns. Conclusions: In summary, most human C. jejuni isolates from Thailand were multi-resistant to quinolones and tetracycline. PFGE detected spatial and temporal C. jejuni clonality responsible for the common sources of Campylobacter gastroenteritis. C1 [Serichantalergs, Oralak; Pootong, Piyarat; Bodhidatta, Ladaporn; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, Bangkok 10400, Thailand. [Serichantalergs, Oralak; Dalsgaard, Anders] Univ Copenhagen, Dept Vet Pathobiol, Fac Life Sci, DK-1870 Frederiksberg C, Denmark. [Guerry, Patricia] USN, Med Res Ctr, Silver Spring, MD 20910 USA. [Tribble, David R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Anuras, Sinn] Bumrungrad Hosp, Bangkok 10110, Thailand. RP Serichantalergs, O (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand. EM oralaks@afrims.org RI Valle, Ruben/A-7512-2013; Guerry, Patricia/A-8024-2011; OI MASON, CARL/0000-0002-3676-2811 FU United States Army Medical Research and Materiel Command in Fort Detrick, MD, USA FX All of the study projects described herein were supported financially by the Military Infectious Diseases Research Program, United States Army Medical Research and Materiel Command in Fort Detrick, MD, USA. We are grateful to the National Laboratory for Enteric Pathogens in Winnipeg, Manitoba, Canada for providing antiserum to perform the Lior serotyping. The views expressed here are those of the authors and are not to be construed as reflecting the views of the United States Department of Defense or the United States Army. NR 43 TC 8 Z9 10 U1 1 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1757-4749 J9 GUT PATHOG JI Gut Pathogens PY 2010 VL 2 AR 15 DI 10.1186/1757-4749-2-15 PG 11 WC Gastroenterology & Hepatology; Microbiology SC Gastroenterology & Hepatology; Microbiology GA V20VM UT WOS:000208167500015 PM 21062505 ER PT J AU Dietrich, CS Greenberg, VL DeSimone, CP Modesitt, SC van Nagell, JR Craven, R Zimmer, SG AF Dietrich, Charles S., III Greenberg, Victoria L. DeSimone, Christopher P. Modesitt, Susan C. van Nagell, John R. Craven, Rolf Zimmer, Stephen G. TI Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Ovarian cancer; Histone deacetylase inhibitor; SAHA; Paclitaxel; Survivin; Bad ID HISTONE-DEACETYLASE INHIBITORS; GYNECOLOGIC-ONCOLOGY-GROUP; EPITHELIAL OVARIAN; PHASE-I; SURVIVIN; VORINOSTAT; TRIAL; AGENTS; CYCLOPHOSPHAMIDE; CHECKPOINT AB Objectives. To determine if SAHA, a histone deacetylase inhibitor, decreases ovarian cancer cell viability when combined with paclitaxel in vitro, and to explore molecular alterations of combined paclitaxel + SAHA treatment. Methods. SKOV3 and Hey ovarian cancer cell lines were treated for 24 h with paclitaxel, then re-treated with SAHA or paclitaxel for an additional 48 It. Protein extracts were prepared at 48 h for western blot analysis. Cell viability was assessed at 72 h using the ApoAlert Annexin V Apoptosis Kit. Results. SAHA causes G1 and G2 cell cycle arrest in ovarian cancer cell lines. Cell viability was significantly reduced by combined paclitaxel + SAHA treatment. In Hey cells, viability was reduced to 67% with paclitaxel, and to 48% with paclitaxel + SAHA (p<0.001). In the SKOV3 cell line, viability was reduced to 70% with continuous paclitaxel treatment, and was further reduced to 57% in the combined treatment group (p<0.05). Increased PARP cleavage was noted in the paclitaxel + SAHA groups. SAHA increased expression of p21cip1/waf1 and p27Kip1, down regulated cyclins A and B, and suppressed CDK1. Paclitaxel induced expression of survivin, an inhibitor Of apoptosis protein, was reduced to baseline control levels with the addition of SAHA. The pro-apoptotic protein, Bad, was also increased with SAHA. Conclusions. Paclitaxel + SAHA reduces cell viability in excess of either agent alone in ovarian cancer cell lines. Cell death is mediated via several mechanisms including G1/G2 arrest from CDK1 downregulation, inhibition of paclitaxel-induced survivin accumulation, and from increased Bad expression. Published by Elsevier Inc. C1 [Dietrich, Charles S., III] Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, Honolulu, HI 96859 USA. [Greenberg, Victoria L.; DeSimone, Christopher P.; van Nagell, John R.; Craven, Rolf; Zimmer, Stephen G.] Univ Kentucky, Div Gynecol Oncol, Dept Obstet & Gynecol, Markey Canc Ctr, Lexington, KY 40536 USA. [Modesitt, Susan C.] Univ Virginia Hlth Syst, Div Gynecol Oncol, Charlottesville, VA 22908 USA. RP Dietrich, CS (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM chuck.dietrich@us.army.mil FU Merck FX Dr. Modesitt received in investigational grant from Merck after this project was completed to further study SAHA. The remaining authors declare no conflicts of interest. NR 35 TC 28 Z9 30 U1 0 U2 8 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JAN PY 2010 VL 116 IS 1 BP 126 EP 130 DI 10.1016/j.ygyno.2009.09.039 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 537JH UT WOS:000273108700023 PM 19875160 ER PT J AU Pittman, RD Shaver, D AF Pittman, Ryan D. Shaver, Dave BE Casey, E TI Windows Forensic Analysis SO HANDBOOK OF DIGITAL FORENSICS AND INVESTIGATION LA English DT Article; Book Chapter C1 [Pittman, Ryan D.] US Army CCIU, Ft Belvoir, VA USA. [Shaver, Dave] US Army, Woodbridge, VA USA. RP Pittman, RD (reprint author), US Army CCIU, Ft Belvoir, VA USA. NR 32 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS BN 978-0-08-092147-1 PY 2010 BP 209 EP 300 DI 10.1016/B978-0-12-374267-4.00005-7 PG 92 WC Criminology & Penology; Medicine, Legal SC Criminology & Penology; Legal Medicine GA BGB48 UT WOS:000322166900006 ER PT J AU Patel, A AF Patel, Anil BE Mazzola, P Kellermanns, FW TI Public sector and strategic management: the case study at the US Army Corps of Engineers SO HANDBOOK OF RESEARCH ON STRATEGY PROCESS LA English DT Article; Book Chapter ID PERFORMANCE; FIT; REFORM; EVOLUTION; MARKETS; FUTURE; ROAD C1 [Patel, Anil] Univ Georgia, Terry Coll Business, Dept Management, Athens, GA 30602 USA. [Patel, Anil] USA, Strategy & Integrat Off, HQ, Corps Engn, Washington, DC 20310 USA. RP Patel, A (reprint author), Univ Georgia, Terry Coll Business, Dept Management, Athens, GA 30602 USA. NR 87 TC 0 Z9 0 U1 0 U2 0 PU EDWARD ELGAR PUBLISHING LTD PI CHELTENHAM PA GLENSANDA HOUSE, MONTPELLIER PARADE, CHELTENHAM GL50 1UA, GLOS, ENGLAND BN 978-1-84844-044-9 PY 2010 BP 519 EP 540 PG 22 WC Business; Management SC Business & Economics GA BZB90 UT WOS:000301062300024 ER PT S AU Fellowes, DA Wood, MV Hastings, AR Draper, RS Lum, AK Ghosh, AP Prache, O Wacyk, I AF Fellowes, David A. Wood, Michael V. Hastings, Arthur R., Jr. Draper, Russell S. Lum, Alden K. Ghosh, Amalkumar P. Prache, Olivier Wacyk, Ihor BE Marasco, PL Havig, PR TI Active matrix organic light emitting diode (AMOLED) performance and life test results SO HEAD- AND HELMET-MOUNTED DISPLAYS XV: DESIGN AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Head- and Helmet-Mounted Displays XV - Design and Applications CY APR 08, 2010 CL Orlando, FL SP SPIE DE AMOLED; OLED; long-life OLED; lifetime; usable display lifetime; SXGA OLED; display; microdisplay AB The US Army and eMagin Corporation established a Cooperative Research and Development Agreement (CRADA) to characterize the ongoing improvements in the lifetime of OLED displays. This CRADA also called for the evaluation of OLED performance as the need arises, especially when new products are developed or when a previously untested parameter needs to be understood. In 2006, eMagin Corporation developed long-life OLED-XL (TM) devices for use in their AMOLED microdisplays for head-worn applications. Through Research and Development programs from 2007 to 2009 with the US Government, eMagin made additional improvements in OLED life and developed the first SXGA (1280 X 1024 triad pixels) OLED microdisplay. US Army RDECOM CERDEC NVESD conducted life and performance tests on these displays, publishing results at the 2007, 2008, and 2009 SPIE Defense and Security Symposia(1,2,3). Life and performance tests have continued through 2009, and this data will be presented along with a recap of previous data. This should result in a better understanding of the applicability of AMOLEDs in military and commercial head mounted systems: where good fits are made, and where further development might be desirable. C1 [Fellowes, David A.; Wood, Michael V.; Hastings, Arthur R., Jr.; Draper, Russell S.; Lum, Alden K.] USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, RDER NVS IM, Ft Belvoir, VA 22060 USA. RP Fellowes, DA (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, RDER NVS IM, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8152-8 J9 PROC SPIE PY 2010 VL 7688 AR 76880A DI 10.1117/12.849235 PG 12 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BSM48 UT WOS:000284936400007 ER PT S AU Harding, TH Rash, CE Lang, GT AF Harding, Thomas H. Rash, Clarence E. Lang, Gregory T. BE Marasco, PL Havig, PR TI Perceptual and Cognitive Effects on the Use of Helmet-Mounted Displays Due to External Operational Factors SO HEAD- AND HELMET-MOUNTED DISPLAYS XV: DESIGN AND APPLICATIONS SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Head- and Helmet-Mounted Displays XV - Design and Applications CY APR 08, 2010 CL Orlando, FL SP SPIE DE Helmet-mounted display; cognition; perception; stressors; operational factors; noise; vibration; heat; cold ID IMAGE STABILIZATION; HUMAN-PERFORMANCE; VIBRATION; HYPOXIA; VISION AB This paper addresses the human component of the human-machine interface and the effects of operational stressors on the user as a system operator. Discussions will strive to link operational stress factors to perception, cognition, and human performance errors and their implications for the design of helmet-mounted displays (HMDs). While many operational stressors can be self-imposed (e. g., fatigue, medication use and smoking), this discussion will focus on environment-related (external) stressors. Generally these factors are characteristics of an environment that require unique countermeasure development versus being under the direct control of the user. These include altitude, noise, vibration, thermal extremes and ambient lighting. Thus, it becomes incumbent upon the HMD designers to be cognizant of these environmental stressors and understand how the Soldier will perform when exposed to these conditions. C1 [Harding, Thomas H.; Rash, Clarence E.] USA, Aeromed Res Lab, Ft Rucker, AL 36330 USA. RP Harding, TH (reprint author), USA, Aeromed Res Lab, POB 620577, Ft Rucker, AL 36330 USA. NR 46 TC 0 Z9 0 U1 1 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8152-8 J9 PROC SPIE PY 2010 VL 7688 AR 76880C DI 10.1117/12.848931 PG 11 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BSM48 UT WOS:000284936400009 ER PT S AU Hiatt, KL Trollman, CJ Rash, CE AF Hiatt, Keith L. Trollman, Christopher J. Rash, Clarence E. BE Marasco, PL Havig, PR TI Aviator's Night Vision System (ANVIS) in Operation Enduring Freedom (OEF): User Acceptability Survey SO HEAD- AND HELMET-MOUNTED DISPLAYS XV: DESIGN AND APPLICATIONS SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Head- and Helmet-Mounted Displays XV - Design and Applications CY APR 08, 2010 CL Orlando, FL SP SPIE DE Helmet-mounted display; HMD; Aviator's Night Vision System; ANVIS; User Satisfaction; Human Factors; Combat AB In 1973, the U. S. Army adopted night vision devices for use in the aviation environment. These devices are based on the principle of image intensification (I(2)) and have become the mainstay for the aviator's capability to operate during periods of low illumination, i.e., at night. In the nearly four decades that have followed, a number of engineering advancements have significantly improved the performance of these devices. The current version, using 3(rd) generation I(2) technology is known as the Aviator's Night Vision Imaging System (ANVIS). While considerable experience with performance has been gained during training and peacetime operations, no previous studies have looked at user acceptability and performance issues in a combat environment. This study was designed to compare Army Aircrew experiences in a combat environment to currently available information in the published literature (all peacetime laboratory and field training studies) and to determine if the latter is valid. The purpose of this study was to identify and assess aircrew satisfaction with the ANVIS and any visual performance issues or problems relating to its use in Operation Enduring Freedom (OEF). The study consisted of an anonymous survey (based on previous validated surveys used in the laboratory and training environments) of 86 Aircrew members (64% Rated and 36% Non-rated) of an Aviation Task Force approximately 6 months into their OEF deployment. This group represents an aggregate of >94,000 flight hours of which similar to 22,000 are ANVIS and similar to 16,000 during this deployment. Overall user acceptability of ANVIS in a combat environment will be discussed. C1 [Hiatt, Keith L.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Hiatt, KL (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. NR 37 TC 0 Z9 0 U1 0 U2 2 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8152-8 J9 P SOC PHOTO-OPT INS PY 2010 VL 7688 AR 76880G DI 10.1117/12.848928 PG 11 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA BSM48 UT WOS:000284936400013 ER PT J AU Hargrave, ML AF Hargrave, Michael L. TI Geophysical Detection of Features and Community Plan at New Philadelphia, Illinois SO HISTORICAL ARCHAEOLOGY LA English DT Article AB Geophysical surveys, including magnetic field gradient and electrical resistance techniques, were conducted at New Philadelphia to identify productive locations for excavation, investigate the community plan, and present students with training in these techniques. Excavation of a sample of the most promising anomalies identified foundations, stone-lined and pit cellars, wells, a privy, and other features. Archival records available during the fieldwork provided no evidence for the presence of four features constructed in the 1840s and 1850s. Features directly associated with houses, such as foundations and cellars, are located very near the platted locations of streets, alleys, and corners, whereas many of the non-residential features occur in the middle portions of lots. C1 US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Hargrave, ML (reprint author), US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU SOC HISTORICAL ARCHAEOLOGY PI ROCKVILLE PA 15245 SHADY GROVE RD, STE 130, ROCKVILLE, MD 20850 USA SN 0440-9213 J9 HIST ARCHAEOL JI Hist. Archaeol. PY 2010 VL 44 IS 1 BP 43 EP 57 PG 15 WC Archaeology SC Archaeology GA 716GO UT WOS:000286957300005 ER PT J AU Johnson, JA AF Johnson, Jeffrey A. BE Dale, TM Foy, JJ TI RAISING THE RED FLAG Culture, Labor, and the Left, 1880-1920 SO HOMER SIMPSON MARCHES ON WASHINGTON: DISSENT THROUGH AMERICAN POPULAR CULTURE LA English DT Article; Book Chapter C1 [Johnson, Jeffrey A.] Providence Coll, Providence, RI 02918 USA. [Johnson, Jeffrey A.] US Mil Acad, West Point, NY USA. [Johnson, Jeffrey A.] Harvard Univ, WEB DuBois Inst, Cambridge, MA 02138 USA. RP Johnson, JA (reprint author), Providence Coll, Providence, RI 02918 USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU UNIV PRESS KENTUCKY PI LEXINGTON PA 102 LAFFERTY HALL, UNIVERSITY OF KENTUCKY, LEXINGTON, KY 40506 USA BN 978-0-8131-7375-7 PY 2010 BP 191 EP 201 PG 11 WC Cultural Studies; Political Science SC Cultural Studies; Government & Law GA BAU57 UT WOS:000305538800012 ER PT J AU Tucker, JS Pleban, RJ Gunther, KM AF Tucker, Jennifer S. Pleban, Robert J. Gunther, Katie M. TI The Mediating Effects of Adaptive Skill on Values-Performance Relationships SO HUMAN PERFORMANCE LA English DT Article ID ORGANIZATIONAL CITIZENSHIP BEHAVIOR; CONTEXTUAL PERFORMANCE; TASK-PERFORMANCE; MODEL; LEADERSHIP; ADAPTABILITY AB Researchers posit that adaptability is an important contributor of performance and that it mediates the effects of distal predictors on performance. As limited empirical evidence supports these relationships, the present research examined whether adaptive skill mediated the effects of values on performance for military leaders. We found that adaptive skill was a distinct construct which uniquely contributed to overall performance. Further, we found that adaptive skill fully mediated the effects of values on technical-administrative behaviors and partially mediated the effects of values on contextual performance and leader behaviors. We discuss the need to further test the nomological network of KSAO-adaptability-performance relationships. C1 [Tucker, Jennifer S.; Pleban, Robert J.] USA, Res Inst, Ft Benning, GA 31995 USA. [Gunther, Katie M.] Auburn Univ, Auburn, AL 36849 USA. RP Tucker, JS (reprint author), USA, Res Inst, POB 52086, Ft Benning, GA 31995 USA. EM Jennifer.S.Tucker@us.army.mil NR 38 TC 6 Z9 7 U1 1 U2 5 PU LAWRENCE ERLBAUM ASSOC INC-TAYLOR & FRANCIS PI PHILADELPHIA PA 325 CHESTNUT STREET, STE 800, PHILADELPHIA, PA 19106 USA SN 0895-9285 J9 HUM PERFORM JI Hum. Perform. PY 2010 VL 23 IS 1 BP 81 EP 99 AR PII 918575648 DI 10.1080/08959280903400275 PG 19 WC Psychology, Applied SC Psychology GA 544CW UT WOS:000273631100005 ER PT J AU Bruder, JT Angov, E Limbach, KJ Richie, TL AF Bruder, Joseph T. Angov, Evelina Limbach, Keith J. Richie, Thomas L. TI Molecular vaccines for malaria SO HUMAN VACCINES LA English DT Review DE malaria; vaccine; antigen; adjuvant; vaccine design; vaccine delivery; vaccine safety ID APICAL MEMBRANE ANTIGEN-1; PLASMODIUM-FALCIPARUM MALARIA; MEROZOITE SURFACE PROTEIN-1; CELLULAR IMMUNE-RESPONSES; VIRUS-LIKE PARTICLES; CD8(+) T-CELL; MEDIATED PROTECTIVE IMMUNITY; DEFECTIVE ADENOVIRUS VECTORS; DIFFERING PLASMID BACKBONES; RANDOMIZED CONTROLLED-TRIAL AB The basic premise of vaccination is the triggering of host immune responses leading to the induction of adaptive immunity having sufficient magnitude and duration to provide long term protection. This has been achieved by many licensed vaccines, the majority based on attenuated or inactivated organisms, although often the protective antigens and underlying molecular mechanisms have not been identified. However, this traditional approach has not led to the development of a licensed vaccine for malaria or for several other devastating infectious diseases. Recently, substantial efforts have been focused on applying rational molecular design principles toward the development of novel vaccines for these refractory pathogens. In this review, we discuss the molecular aspects of antigen design, adjuvant advancement and the development of vaccine delivery systems as they are being applied to malaria vaccines. C1 [Bruder, Joseph T.] GenVec Inc, Gaithersburg, MD USA. [Angov, Evelina; Limbach, Keith J.; Richie, Thomas L.] US Mil Malaria Vaccine Program, Silver Spring, MD USA. [Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Limbach, Keith J.; Richie, Thomas L.] USN, Med Res Ctr, Silver Spring, MD USA. RP Bruder, JT (reprint author), GenVec Inc, Gaithersburg, MD USA. EM jbruder@genvec.com OI Richie, Thomas/0000-0002-2946-5456 FU [RAD1.F.A0309] FX We thank Ashley Birkett for assistance in generating the manuscript outline, Doug Brough for his review of the entire manuscript, Sheetij Dutta, Yimin Wu and Shannon Takala for their reviews of the sections describing their laboratory's work on AMA1, David Lanar for his review of the sections on SAPNs, Blaise Genton for his review of the update on virosomes and Graham Bentley for his review of the legend for Figure 2. We are grateful to Gary Brice, Adrian Hill, Tupur Husain, David Lanar and Annie Mo for their personal communications, to Judith Epstein, Birgitte Giersing, Gregory Mullen and Vasee Moorthy for permission to republish Figure 1, to Edmond Remarque, Bart Faber and Henk van Westbroek for the original figure of the PfAMA1 crystal structure and legend in Figure 2 and to David Lanar for permission to publish the SAPN diagram and murine protection data in Figure 4. The study protocols for the clinical trials discussed in the manuscript that were performed by the US Navy or US Army were approved by the Naval Medical Research Center or Walter Reed Army Institute of Research Institutional Review Boards, respectively, in compliance with all applicable Federal regulations governing the protection of human subjects. Likewise, the animal experiments reported herein that were conducted by the US Navy or US Army were conducted in compliance with the Animal Welfare Act and in accordance with the principles set forth in the "Guide for the Care and Use of Laboratory Animals," Institute of Laboratory Animals Resources, National Research Council, National Academy Press, 1996. TLR is a military service member and EA is an employee of the U. S. Government. The work of TLR and EA was prepared as part of official government duties. Title 17 U.S.C. S105 provides that 'Copyright protection under this title is not available for any work of the United States Government.' Title 17 U.S.C. S101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person's official duties. The work of KL and TLR was supported by work unit number 6000. RAD1.F.A0309. NR 263 TC 17 Z9 17 U1 0 U2 1 PU LANDES BIOSCIENCE PI AUSTIN PA 1806 RIO GRANDE ST, AUSTIN, TX 78702 USA SN 1554-8600 J9 HUM VACCINES JI Hum. Vaccines PD JAN PY 2010 VL 6 IS 1 BP 54 EP 77 PG 24 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 557DT UT WOS:000274650200009 PM 20061792 ER PT B AU Boulton, ME Sliney, DH AF Boulton, Michael E. Sliney, David H. BA Baxter, PJ Aw, TC Cockcroft, A Durrington, P Harrington, JM BF Baxter, PJ Aw, TC Cockcroft, A Durrington, P Harrington, JM TI Non-ionizing radiation and the eye SO HUNTER'S DISEASES OF OCCUPATIONS, 10TH EDITION LA English DT Article; Book Chapter ID RETINAL INJURY; ULTRAVIOLET-RADIATION; OPTICAL RADIATION; OCULAR INJURIES; LASER EXPOSURE; WELDING ARC; 400 NM; LIGHT; CATARACT; DAMAGE C1 [Boulton, Michael E.] Univ Florida, Dept Anat & Cell Biol, Gainesville, FL 32611 USA. [Sliney, David H.] US Army Ctr Hlth Promot & Prevent Med, Laser Opt Radiat Program, Aberdeen Proving Ground, MD USA. RP Boulton, ME (reprint author), Univ Florida, Dept Anat & Cell Biol, Gainesville, FL 32611 USA. NR 90 TC 0 Z9 0 U1 0 U2 0 PU HODDER AND STAUGHTON LTD PI LONDON PA 338 EUSTON RD, LONDON, NW1 3BH, ENGLAND BN 978-1-4441-2843-7; 978-0-340-94166-9 PY 2010 BP 644 EP 662 D2 10.1201/b13467 PG 19 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA BC8CQ UT WOS:000355550500055 ER PT S AU Nguyen, HV Cheng, JRC Hammack, EA Maier, RS AF Nguyen, Hung V. Cheng, Jing-Ru C. Hammack, E. Allen Maier, Robert S. GP ICCS BE Sloot, PMA Albada, GDV Dongarra, J TI Parallel Newton-Krylov solvers for modeling of a navigation lock filling system SO ICCS 2010 - INTERNATIONAL CONFERENCE ON COMPUTATIONAL SCIENCE, PROCEEDINGS SE Procedia Computer Science LA English DT Proceedings Paper CT International Conference on Computational Science (ICCS) CY MAY 31-JUN 02, 2010 CL Univ Amsterdam, Amsterdam, NETHERLANDS SP NWO, Netherlands Org Sci Res, KNAW, Royal Netherlands Acad Arts & Sci, Elsevier, Univ Amsterdam HO Univ Amsterdam DE Navigation lock; iterative solvers; ADH; PETSc; turbulent flow ID NONSYMMETRIC LINEAR-SYSTEMS; BI-CG; ALGORITHM; GMRES AB The Galerkin least-squares finite element method for solving the Reynolds-averaged incompressible turbulent 3-D Navier-Stokes equations is employed to simulate a navigation lock filling system in the numerical code Adaptive Hydraulics (ADH). The linear system is solved at each nonlinear iteration within every time-step using biconjugate gradient stabilized (BiCGstab) in combination with block-Jacobi (bjacobi) preconditioners, as it failed to solve the linear system because of dramatic changes in flow velocity and pressure early in the simulation. To overcome this problem, we used the Portable Extensible Toolkit for Scientific Computation (PETSc), a numerical library that provides multiple types of linear solvers. PETSc has been incorporated into the ADH code. The ADH-PETSc interface helps to systematically investigate the best linear solver for an ADH simulation. We found that a variant, known as enhanced BiCGstab(l) in combination with the additive Schwarz method (ASM), made it possible to simulate the John Day lock filling system. The BiCGstab(l) solver improved the rate of convergence because of a more reliable update strategy for the residuals. In addition, the simulation was run with various numbers of processors. The result shows good scaling of solution time as the number of processors increases (C) 2010 Published by Elsevier Ltd. C1 [Nguyen, Hung V.; Cheng, Jing-Ru C.; Maier, Robert S.] USA, ERDC, ITL, Vicksburg, MS 39180 USA. [Hammack, E. Allen] USA, ERDC, CHL, Vicksburg, MS 39180 USA. RP Nguyen, HV (reprint author), USA, ERDC, ITL, Vicksburg, MS 39180 USA. EM Hung.V.Nguyen@usace.army.mil FU U.S. Army Corps of Engineers; Engineer Research and Development Center; Civil Works basic research program; DoD High Performance Computing Modernization Program FX This study was supported by the U.S. Army Corps of Engineers, Engineer Research and Development Center, Civil Works basic research program. It was also supported in part by an allocation of computer time from the DoD High Performance Computing Modernization Program. NR 15 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1877-0509 J9 PROCEDIA COMPUT SCI PY 2010 VL 1 IS 1 BP 699 EP 707 DI 10.1016/j.procs.2010.04.075 PG 9 WC Computer Science, Theory & Methods SC Computer Science GA BQV31 UT WOS:000281951600074 ER PT S AU Eller, PR Cheng, JRC Nguyen, HV Maier, RS AF Eller, Paul R. Cheng, Jing-Ru C. Nguyen, Hung V. Maier, Robert S. GP ICCS BE Sloot, PMA Albada, GDV Dongarra, J TI Improving parallel performance of large-scale watershed simulations SO ICCS 2010 - INTERNATIONAL CONFERENCE ON COMPUTATIONAL SCIENCE, PROCEEDINGS SE Procedia Computer Science LA English DT Proceedings Paper CT International Conference on Computational Science (ICCS) CY MAY 31-JUN 02, 2010 CL Univ Amsterdam, Amsterdam, NETHERLANDS SP NWO, Netherlands Org Sci Res, KNAW, Royal Netherlands Acad Arts & Sci, Elsevier, Univ Amsterdam HO Univ Amsterdam DE Watershed Model; MPI; PETSc; Linear Solvers; Preconditioners AB A comprehensive, physics-based watershed model with multispatial domains and multitemporal scales has been developed and used. This paper discusses interfacing the watershed model with PETSc and evaluating the model performance for a variety of PETSc preconditioners. Both wall-clock time and scalability are compared based on performance on the Cray XT4 machine, along with tests to verify that all solutions are producing accurate results. The findings conclude that the PETSc Conjugate Gradient solver and preconditioners outperform the simple Conjugate Gradient solver and Jacobi preconditioner originally used by the watershed model. Tests show that the Hypre-Boomeramg preconditioner provides the most significant speedup for the watershed model. (C) 2010 Published by Elsevier Ltd. C1 [Eller, Paul R.; Cheng, Jing-Ru C.; Nguyen, Hung V.; Maier, Robert S.] USA, Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS 39180 USA. RP Eller, PR (reprint author), USA, Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1877-0509 J9 PROCEDIA COMPUT SCI PY 2010 VL 1 IS 1 BP 801 EP 808 DI 10.1016/j.procs.2010.04.086 PG 8 WC Computer Science, Theory & Methods SC Computer Science GA BQV31 UT WOS:000281951600085 ER PT S AU Hodo, DW Bevly, DM Hung, JY Millhouse, S Selfridge, B AF Hodo, David W. Bevly, David M. Hung, John Y. Millhouse, Scott Selfridge, Bob GP IEEE TI Optimal Path Planning with Obstacle Avoidance for Autonomous Surveying SO IECON 2010 - 36TH ANNUAL CONFERENCE ON IEEE INDUSTRIAL ELECTRONICS SOCIETY SE IEEE Industrial Electronics Society LA English DT Proceedings Paper CT 36th Annual Conference of the IEEE Industrial-Electronics-Society (IECON)/4th IEEE International Conference on E-Learning in Industrial Electronics/IES Industry Forum CY NOV 07-10, 2010 CL Glendale, AZ SP Inst Elect & Elect Engineers (IEEE), IEEE Ind Elect Soc, New Jersey Sci & Technol Univ, New Jersey Inst Technol (NJIT), N Carolina State Univ (NCSU), Soc Instrument & Control Engineers (SICE), Auburn Univ, Intel, Altera, IEEE Phoenix Sect AB In order to perform surveying with an autonomous vehicle, a path must often be designed for geometrically complex boundaries, while also accounting for mapped obstacles. In this paper, several algorithms that solve different aspects of the problem are presented. Together, the algorithms generate a path with the following characteristics: (a) it completely covers a field given its respective corner points, (b) considers the desired initial orientation of the vehicle, (c) provides methods for known obstacles to be avoided by defining areas that are not to be mapped, and (d) can cover a composition of multiple, disjoint fields. The algorithm represents an integration of several theoretical concepts, including: Dubins's paths for basic planning, modified visibility graphs to define feasible paths around obstacles, Dijkstra's algorithm to search for the shortest path, and ... C1 [Hodo, David W.; Hung, John Y.] Auburn Univ, Elect & Comp Engn Dept, Auburn, AL 36849 USA. [Bevly, David M.] Auburn Univ, Dept Engn Mech, Auburn, AL 36849 USA. [Millhouse, Scott; Selfridge, Bob] US Army Corps Engn, Engn & Support Ctr, Huntsville, AL 35807 USA. RP Hodo, DW (reprint author), Auburn Univ, Elect & Comp Engn Dept, Auburn, AL 36849 USA. EM hododav@auburn.edu; Bob.J.Selfridge@usace.army.mil FU U.S. Army Corps of Engineers and the Environmental Security Technology Certification Program (ESTCP) FX The authors express thanks for the support from the U.S. Army Corps of Engineers and the Environmental Security Technology Certification Program (ESTCP). NR 14 TC 0 Z9 0 U1 0 U2 0 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1553-572X BN 978-1-4244-5226-2 J9 IEEE IND ELEC PY 2010 PG 7 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA BYT36 UT WOS:000300146000096 ER PT S AU Zaidi, SSH Zanardelli, WG Aviyente, S Strangas, EG AF Zaidi, Sycd Sajjad H. Zanardelli, Wesley G. Aviyente, Selin Strangas, E. G. GP IEEE TI Prognosis of Electrical Faults in Permanent Magnet AC Machines using the Hidden Markov Model SO IECON 2010 - 36TH ANNUAL CONFERENCE ON IEEE INDUSTRIAL ELECTRONICS SOCIETY SE IEEE Industrial Electronics Society LA English DT Proceedings Paper CT 36th Annual Conference of the IEEE Industrial-Electronics-Society (IECON)/4th IEEE International Conference on E-Learning in Industrial Electronics/IES Industry Forum CY NOV 07-10, 2010 CL Glendale, AZ SP Inst Elect & Elect Engineers (IEEE), IEEE Ind Elect Soc, New Jersey Sci & Technol Univ, New Jersey Inst Technol (NJIT), N Carolina State Univ (NCSU), Soc Instrument & Control Engineers (SICE), Auburn Univ, Intel, Altera, IEEE Phoenix Sect ID TIME-FREQUENCY ANALYSIS; SYNCHRONOUS MACHINES; INDUCTION MACHINES; WAVELET TRANSFORM; DIAGNOSIS; MOTORS; CLASSIFICATION; CONNECTIONS; TRACKING AB Reliable and fault free operation of machines needs not only timely fault detection and classification, but also an estimate of its remaining useful life, resulting in two phases of systems health monitoring, diagnosis and prognosis. Both share commonalities, with prognosis being the succeeding phase of diagnosis. In this paper, a prognosis algorithm based on the statistical hidden Markov model, is presented for the electrical faults of permanent magnet AC machines. The model parameters are computed by using the training outputs of the diagnosis phase. The algorithm estimates the failure state probability for each sampled observation. Time-frequency features extracted from the torque producing component of the machine current is used as the health indicator. The remaining useful life is estimated in terms of the probability of failure state. Parameter training of Hidden Markov Models generally need huge amounts of historical data, which are often not available in the case of highly reliable electrical machines. A method, which uses experimental observations, is presented for the computation of the state dependent observation probability densities from the limited data C1 [Zaidi, Sycd Sajjad H.; Aviyente, Selin; Strangas, E. G.] Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. [Zanardelli, Wesley G.] US Army TARDEC, Hybrid Elect Res, Warren, MI 48397 USA. RP Zaidi, SSH (reprint author), Michigan State Univ, Dept Elect & Comp Engn, E Lansing, MI 48824 USA. EM zaidisy1@msu.edu NR 38 TC 0 Z9 0 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 1553-572X BN 978-1-4244-5226-2 J9 IEEE IND ELEC PY 2010 PG 7 WC Automation & Control Systems; Engineering, Electrical & Electronic SC Automation & Control Systems; Engineering GA BYT36 UT WOS:000300146001101 ER PT J AU Weiss, SJ Kilic, O AF Weiss, Steven J. Kilic, Ozlem TI A Vector Transform Solution Procedure for Solving Electromagnetic Problems in Cartesian Coordinates SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Microstrip antenna; planar Green's function; stratified media; vector transforms ID ANTENNAS AB Some vector transforms of importance to solving electromagnetic problems were introduced by Chew and Habashy in 1986. The primary advantage gained in the use of these transforms is that the analytical development of field solutions becomes streamlined by what amounts to a very powerful bookkeeping method. The aforementioned paper presents transforms for Cartesian, cylindrical, and elliptical geometries. A later paper by Weiss and Kahn demonstrated that these transforms emerge from careful consideration of the longitudinal components of the electric and magnetic fields. Applying the techniques to the Cartesian geometry, one finds a variation to the vector transform postulated by Chew and Habashy. This letter will discuss the analytical formulation of the variation and demonstrate its usefulness in the development of Green's functions for a planar stratified medium. The foundation of this variation to the well-established development in Chew and Habashy's work lies in obtaining it solely from consideration of the longitudinal electric and magnetic field components. This method then simplifies the derivations and necessary bookkeeping. Although demonstrated here for a simple geometry, the approach applies to multiple layers as effectively. C1 [Weiss, Steven J.] USA, Res Lab, Adelphi, MD 20783 USA. [Kilic, Ozlem] Catholic Univ Amer, Washington, DC 20064 USA. RP Weiss, SJ (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM steven.weiss@us.army.mil NR 7 TC 1 Z9 1 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2010 VL 9 BP 291 EP 294 DI 10.1109/LAWP.2010.2047230 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 588ES UT WOS:000277051000001 ER PT J AU Zaghloul, AI Kilic, O AF Zaghloul, Amir I. Kilic, Ozlem TI Hybrid Beam Former for Distributed-Aperture Electronically Steered Arrays SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Beam forming; conformal arrays; electronic scanning; phased arrays; vehicle antennas ID BUTLER MATRIX; ANTENNA; DESIGN AB This letter presents a concept for a hybrid beam former that is composed of two stages: an RF stage with limited scanning steps and a digital stage that is capable of steering multiple beams of different channels in all required directions. The two-stage beam former uses fewer A/D converters than its all-digital counterpart and lower losses than the all-RF beam former. Examples are given for multifaceted or conformal apertures. Although the examples are limited to one-dimensional (1-D) scanning, the concept is valid for two-dimensional (2-D) scanning as well. C1 [Zaghloul, Amir I.] Virginia Polytech Inst & State Univ, Falls Church, VA 22043 USA. [Zaghloul, Amir I.] USA, Res Lab, Adelphi, MD 20783 USA. [Kilic, Ozlem] Catholic Univ Amer, Washington, DC 20001 USA. RP Zaghloul, AI (reprint author), Virginia Polytech Inst & State Univ, Falls Church, VA 22043 USA. EM amirz@vt.edu; kilic@cua.edu NR 9 TC 0 Z9 0 U1 0 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2010 VL 9 BP 678 EP 681 DI 10.1109/LAWP.2010.2053512 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 664EK UT WOS:000282942600003 ER PT J AU Keller, SD Palmer, WD Joines, WT AF Keller, Steven D. Palmer, W. Devereux Joines, William T. TI Electromagnetic Modeling and Simulation of a Directly Modulated Patch Antenna SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Computational electromagnetics; direct modulation; p-i-n diode; patch antenna ID RESONATORS AB The direct modulation of an L-band microstrip patch antenna with integrated fast-switching p-i-n diodes is explored over a range of modulation frequencies well beyond the resonant bandwidth of the antenna. Electromagnetic simulation of one embodiment of a directly modulated antenna, including an equivalent circuit model for the p-i-n diode as a function of bias voltage, provides insight into the mechanisms behind the modulation effect and serves as a design tool to optimize and predict the modulation of the antenna radiation pattern. C1 [Keller, Steven D.] USA, Res Lab, Adelphi, MD 20783 USA. [Palmer, W. Devereux] USA, Res Off, Res Triangle Pk, NC 27703 USA. [Joines, William T.] Duke Univ, Elect & Comp Engn Dept, Durham, NC 27708 USA. RP Keller, SD (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM steven.keller4@us.army.mil; dev.palmer@us.army.mil; wtj@ee.duke.edu RI Palmer, William/E-2296-2012 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-04-D-0001] FX Manuscript received June 25, 2010; revised July 26, 2010; accepted July 26, 2010. Date of publication August 05, 2010; date of current version August 16, 2010. This work was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Agreement W911NF-04-D-0001, Delivery Order 0003. NR 6 TC 3 Z9 3 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2010 VL 9 BP 779 EP 782 DI 10.1109/LAWP.2010.2063414 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 666PR UT WOS:000283128800002 ER PT J AU Keller, SD Palmer, WD Joines, WT AF Keller, Steven D. Palmer, W. Devereux Joines, William T. TI Switched Antenna Circuit With Increased Information Bandwidth SO IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS LA English DT Article DE Computational electromagnetics; direct modulation; patch antenna; p-i-n diode AB An L-band microstrip patch antenna is directly modulated with fast-switching p-i-n diodes over a range of modulation frequencies well beyond the resonant bandwidth of the antenna. The experimental results, in both the time and frequency domains, show that by using this direct modulation technique, a narrowband patch antenna with a -10 -dB reflection coefficient bandwidth of 28 MHz successfully transmits a directly modulated signal with a bandwidth greater than 300 MHz. C1 [Keller, Steven D.] USA, Res Lab, Adelphi, MD 20783 USA. [Palmer, W. Devereux] USA, Res Off, Res Triangle Pk, NC 27703 USA. [Joines, William T.] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA. RP Keller, SD (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM steven.keller4@us.army.mil; dev.palmer@us.army.mil; wtj@ee.duke.edu RI Palmer, William/E-2296-2012 FU U.S. Army Research Laboratory; U.S. Army Research Office [W911NF-04-D-0001, 0003] FX This work was supported in part by the U.S. Army Research Laboratory and the U.S. Army Research Office under Agreement Number W911NF-04-D-0001, Delivery Order 0003. NR 5 TC 1 Z9 1 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-1225 J9 IEEE ANTENN WIREL PR JI IEEE Antennas Wirel. Propag. Lett. PY 2010 VL 9 BP 1045 EP 1048 DI 10.1109/LAWP.2010.2089775 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 682OD UT WOS:000284412000004 ER PT J AU Ho, J Jow, TR Boggs, S AF Ho, Janet Jow, T. Richard Boggs, Steven TI Historical Introduction to Capacitor Technology SO IEEE ELECTRICAL INSULATION MAGAZINE LA English DT Article DE capacitor; capacitor history; ceramic capacitor; film capacitor; double layer capacitor; electrochemical capacitor C1 [Ho, Janet; Jow, T. Richard] USA, Res Lab, Adelphi, MD USA. [Boggs, Steven] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA. RP Ho, J (reprint author), USA, Res Lab, Adelphi, MD USA. EM janet.ho@arl.army.mil NR 8 TC 21 Z9 21 U1 5 U2 34 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0883-7554 J9 IEEE ELECTR INSUL M JI IEEE Electr. Insul. Mag. PD JAN-FEB PY 2010 VL 26 IS 1 BP 20 EP 25 DI 10.1109/MEI.2010.5383924 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA 546CA UT WOS:000273784700005 ER PT S AU O'Brien, B Stump, E Pierce, C AF O'Brien, Barry Stump, Ethan Pierce, Cynthia GP IEEE TI Effects of Increasing Autonomy on Tele-Operation Performance SO IEEE/RSJ 2010 INTERNATIONAL CONFERENCE ON INTELLIGENT ROBOTS AND SYSTEMS (IROS 2010) SE IEEE International Conference on Intelligent Robots and Systems LA English DT Proceedings Paper CT IEEE/RSJ International Conference on Intelligent Robots and Systems CY OCT 18-22, 2010 CL Taipei, TAIWAN ID ROBOTS AB Tele-operation of robotic platforms has long suffered from the inability of the operator to effectively perform ancillary tasks while controlling the robot. Because of the focus required to perform tele-operation, the operator is limited in their ability to use the robot to improve their situational awareness, with tele-operation often becoming a detriment to their task rather than an enhancement. We present experimental results on the use of a tele-operated robotic system modified to include layered obstacle detection and avoidance routines and an open space planner. These algorithms help the operator shift their focus towards high-level tasks instead of low-level navigation. While experimental data shows that the increase in autonomy did not lead to a reduction in task completion time, obstacle collisions were reduced and has led to further investigation of cognitive load reduction during operation. C1 [O'Brien, Barry; Stump, Ethan; Pierce, Cynthia] USA, Res Lab, Temple, TX 76502 USA. RP O'Brien, B (reprint author), USA, Res Lab, Temple, TX 76502 USA. NR 24 TC 1 Z9 1 U1 1 U2 3 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA SN 2153-0858 BN 978-1-4244-6675-7 J9 IEEE INT C INT ROBOT PY 2010 BP 1792 EP 1798 DI 10.1109/IROS.2010.5652709 PG 7 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Robotics SC Computer Science; Robotics GA BTO97 UT WOS:000287672001080 ER PT J AU Hansson, J Wrage, L Feiler, PH Morley, J Lewis, B Hugues, J AF Hansson, Joergen Wrage, Lutz Feiler, Peter H. Morley, John Lewis, Bruce Hugues, Jerome TI Architectural Modeling to Verify Security and Nonfunctional Behavior SO IEEE SECURITY & PRIVACY LA English DT Article C1 [Hansson, Joergen; Wrage, Lutz; Feiler, Peter H.; Lewis, Bruce] Carnegie Mellon Univ, Inst Software Engn, Architecture Centr Engn Initiat, Pittsburgh, PA 15213 USA. [Lewis, Bruce] USA, Aviat & Missile Commands Res Dev & Engn Lab, Software Engn Directorate, Washington, DC USA. [Hugues, Jerome] ParisTech, Inst Telecom, Networks & Comp Sci Dept, Paris, France. RP Hansson, J (reprint author), Carnegie Mellon Univ, Inst Software Engn, Architecture Centr Engn Initiat, Pittsburgh, PA 15213 USA. EM hansson@sei.cmu.edu; lwrage@sei.cmu.edu; phf@sei.cmu.edu; jmorley@sei.cmu.edu; bruce.a.lewis@usarmy.mil; hugues@telecom-paristech.fr RI Hugues, Jerome/I-3663-2015 OI Hugues, Jerome/0000-0003-0148-7175 NR 17 TC 2 Z9 2 U1 0 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD JAN-FEB PY 2010 VL 8 IS 1 BP 43 EP 49 PG 7 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 555QE UT WOS:000274527500007 ER PT J AU Gani, A Gribok, AV Lu, YH Ward, WK Vigersky, RA Reifman, J AF Gani, Adiwinata Gribok, Andrei V. Lu, Yinghui Ward, W. Kenneth Vigersky, Robert A. Reifman, Jaques TI Universal Glucose Models for Predicting Subcutaneous Glucose Concentration in Humans SO IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE LA English DT Article DE Diabetes; glucose prediction; glucose regulation; inverse problems; mathematical model; regularization; system dentification ID DYNAMICS AB This paper tests the hypothesis that a "universal," data-driven model can be developed based on glucose data from one diabetic subject, and subsequently applied to predict subcutaneous glucose concentrations of other subjects, even of those with different types of diabetes. We employed three separate studies, each utilizing a different continuous glucose monitoring (CGM) device, to verify the model's universality. Two out of the three studies involved subjects with type 1 diabetes and the other one with type 2 diabetes. We first filtered the subcutaneous glucose concentration data by imposing constraints on their rate of change. Then, using the filtered data, we developed data-driven autoregressive models of order 30, and used them to make short-term, 30-min-ahead glucose-concentration predictions. We used same-subject model predictions as a reference for comparisons against cross-subject and cross-study model predictions, which were evaluated using the root-mean-squared error (RMSE) and Clarke error grid analysis (EGA). We found that, for each studied subject, the average cross-subject and cross-study RMSEs of the predictions were small and indistinguishable from those obtained with the same-subject models. These observations were corroborated by EGA, where better than 99.0% of the paired sensor-predicted glucose concentrations lay in the clinically acceptable zone A. In addition, the predictive capability of the models was found not to be affected by diabetes type, subject age, CGM device, and interindividual differences. We conclude that it is feasible to develop universal glucose models that allow for clinical use of predictive algorithms and CGM devices for proactive therapy of diabetic patients. C1 [Gani, Adiwinata; Lu, Yinghui; Reifman, Jaques] USA, Bioinformat Cell Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Gribok, Andrei V.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA. [Ward, W. Kenneth] Oregon Hlth & Sci Univ, Wilsonville, OR 97070 USA. [Ward, W. Kenneth] ISense Corp, Wilsonville, OR 97070 USA. [Vigersky, Robert A.] Walter Reed Army Med Ctr, Inst Diabet, Washington, DC 20307 USA. RP Gani, A (reprint author), Asia Pulp & Paper Sinarmas Grp, Jakarta, Indonesia. EM adiwinata.gani@gmail.com; agribok@bioanalysis.org; ylu@bioanalysis.org; kenward503@msn.com; Robert.Vigersky@amedd.army.mil; jaques.reifman@us.army.mil FU U. S. Army Medical Department, Advanced Medical Technology Initiative; U. S. Army Medical Research and Materiel Command, Fort Detrick, MD FX This work was supported by the U. S. Army Medical Department, Advanced Medical Technology Initiative, funded by the Telemedicine and Advanced Technology Research Center of the U. S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 17 TC 43 Z9 44 U1 0 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1089-7771 J9 IEEE T INF TECHNOL B JI IEEE T. Inf. Technol. Biomed. PD JAN PY 2010 VL 14 IS 1 BP 157 EP 165 DI 10.1109/TITB.2009.2034141 PG 9 WC Computer Science, Information Systems; Computer Science, Interdisciplinary Applications; Mathematical & Computational Biology; Medical Informatics SC Computer Science; Mathematical & Computational Biology; Medical Informatics GA 545CQ UT WOS:000273710500021 PM 19858035 ER PT J AU Ballato, A AF Ballato, Arthur TI Poisson's Ratios of Auxetic and Other Technological Materials SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article; Proceedings Paper CT Joint Meeting of the European Frequency and Time Forum/IEEE International Frequency Control Symposium CY 2009 CL Besancon, FRANCE SP IEEE ID CUBIC MATERIALS; YOUNGS MODULUS; QUARTZ PLATES; SHEAR MODULUS; CRYSTALS; ELASTICITY; VIBRATIONS AB Poisson's ratio, the relation between lateral contraction of a thin, linearly elastic rod when subjected to a longitudinal extension, has a long and interesting history. For isotropic bodies, it can theoretically range from + 1/2 to -1; the experimental gamut for anisotropics is even larger. The ratio is positive for all combinations of directions in most crystals. But as far back as the 1800s, Voigt and others found that negative values were encountered for some materials, a property now called auxeticity. Here we examine this property from the point of view of crystal stability and compute extrema of the ratio for various interesting and technologically important materials. Potential applications of the auxetic property are mentioned. C1 US Army Commun Elect RDEC, Ft Monmouth, NJ USA. RP Ballato, A (reprint author), US Army Commun Elect RDEC, Ft Monmouth, NJ USA. EM a.ballato@ieee.org NR 58 TC 11 Z9 11 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JAN PY 2010 VL 57 IS 1 SI SI BP 7 EP 15 DI 10.1109/TUFFC.2010.1372 PG 9 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA 604PE UT WOS:000278290200002 PM 20040420 ER PT J AU Chen, CH Yucesan, E Dai, LY Chen, HC AF Chen, Chun-Hung Yuecesan, Enver Dai, Liyi Chen, Hsiao-Chang TI Optimal budget allocation for discrete-event simulation experiments SO IIE TRANSACTIONS LA English DT Article DE Discrete-event simulation; simulation optimization; simulation uncertainty ID STAGE SAMPLING ALLOCATIONS; ORDINAL OPTIMIZATION; SELECTION PROCEDURES; RANKING; PROBABILITY; SUBSET AB Simulation plays a vital role in analyzing discrete-event systems, particularly in comparing alternative system designs with a view to optimizing system performance. Using simulation to analyze complex systems, however, can be both prohibitively expensive and time-consuming. Effective algorithms to allocate intelligently a computing budget for discrete-event simulation experiments are presented in this paper. These algorithms dynamically determine the simulation lengths for all simulation experiments and thus significantly improve simulation efficiency under the constraint of a given computing budget. Numerical illustrations are provided and the algorithms are compared with traditional two-stage ranking-and-selection procedures through numerical experiments. Although the proposed approach is based on heuristics, the numerical results indicate that it is much more efficient than the compared procedures. C1 [Chen, Chun-Hung] George Mason Univ, Dept Syst Engn & Operat Res, Fairfax, VA 22030 USA. [Yuecesan, Enver] INSEAD, F-77305 Fontainebleau, France. [Dai, Liyi] USA, Res Off, Res Triangle Pk, NC 27709 USA. [Chen, Hsiao-Chang] E2OPEN Inc, Taipei, Taiwan. RP Chen, CH (reprint author), George Mason Univ, Dept Syst Engn & Operat Res, 4400 Univ Dr,MS 4A6, Fairfax, VA 22030 USA. EM cchen9@gmu.edu RI Yucesan, Enver/B-4374-2010 FU Department of Energy [DE-SC0002223]; National Science Council of the Republic of China [NSC 95-2811-E-002-009]; NSF [IIS-0325074]; NASA Ames Research Center [NAG-2-1643, NNA05CV26G]; FAA [00-G-016] FX This work has been supported in part by the Department of Energy under grant DE-SC0002223 the National Science Council of the Republic of China under grant NSC 95-2811-E-002-009, by NSF under grant IIS-0325074, by NASA Ames Research Center under grants NAG-2-1643 and NNA05CV26G and by the FAA under grant 00-G-016. The authors would like to thank Professors David Goldsman, Stephen Chick and Barry Nelson for their helpful suggestions and valuable comments, which significantly improved the exposition of this paper. NR 34 TC 27 Z9 27 U1 1 U2 6 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 0740-817X J9 IIE TRANS JI IIE Trans. PY 2010 VL 42 IS 1 BP 60 EP 70 DI 10.1080/07408170903116360 PG 11 WC Engineering, Industrial; Operations Research & Management Science SC Engineering; Operations Research & Management Science GA 547WB UT WOS:000273919300005 ER PT B AU Reuss, M Cutcliffe, SH AF Reuss, Martin Cutcliffe, Stephen H. BE Reuss, M Cutcliffe, SH TI The Illusory Boundary Environment and Technology in History Introduction SO ILLUSORY BOUNDARY: ENVIRONMENT AND TECHNOLOGY IN HISTORY LA English DT Editorial Material; Book Chapter C1 [Cutcliffe, Stephen H.] Lehigh Univ, Dept Hist, Bethlehem, PA USA. [Reuss, Martin] USA, Corps Engineers, Washington, DC USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU UNIV PRESS VIRGINIA PI CHARLOTTESVILLE PA P O BOX 400318,, CHARLOTTESVILLE, VA 22904-4318 USA BN 978-0-8139-2989-7 PY 2010 BP 1 EP 6 PG 6 WC History & Philosophy Of Science SC History & Philosophy of Science GA BDA36 UT WOS:000312293000001 ER PT B AU Reuss, M AF Reuss, Martin BE Reuss, M Cutcliffe, SH TI The Illusory Boundary Environment and Technology in History Afterword SO ILLUSORY BOUNDARY: ENVIRONMENT AND TECHNOLOGY IN HISTORY LA English DT Editorial Material; Book Chapter C1 [Reuss, Martin] USA, Corps Engineers, Washington, DC USA. NR 42 TC 0 Z9 0 U1 0 U2 0 PU UNIV PRESS VIRGINIA PI CHARLOTTESVILLE PA P O BOX 400318,, CHARLOTTESVILLE, VA 22904-4318 USA BN 978-0-8139-2989-7 PY 2010 BP 291 EP 301 PG 11 WC History & Philosophy Of Science SC History & Philosophy of Science GA BDA36 UT WOS:000312293000013 ER PT B AU Jankowski, NR Morgan, BC McCluskey, FP AF Jankowski, Nicholas R. Morgan, Brian C. McCluskey, F. Patrick GP ASME TI DESIGN AND FABRICATION OF A SUBSTRATE INTEGRATED PHASE CHANGE THERMAL BUFFER HEAT SINK SO IMCE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 5 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME ID ENERGY-STORAGE; MANAGEMENT AB Recent power electronics cooling efforts have shown that bringing the cooling mechanism directly into the device substrate can achieve reduced package thermal resistance and reduced system pumping requirements while maintaining traditional circuit manufacturing processes. At the same time, it has been demonstrated that effective compact methods of managing electronic temperature excursions from brief power surges or other transient events include the use of a solid-liquid phase change material (PCM), but tight integration into the electronics package without degrading overall cooling has proven difficult. Recognizing that such a thermal buffer heat sink (TBHS) would enable lighter weight, more compact cooling hardware for vehicle power electronic modules, the U.S. Army Research Laboratory has developed a method for integrating and assembling a PCM-based TBHS within a power electronics substrate. The TBHS design builds upon both the author's previous efforts in substrate integrated cooling and design trade studies sponsored by the Department of Energy. By fabricating the PCM cavities alongside the fluidic passages on the backside of a ceramic substrate, the PCM thermal bottleneck can be minimized, and a compact solution can be found. Low fabrication temperature limits imposed by the presence of an integrated PCM can be circumvented by using a room temperature curing silicone bonding layer for assembly. The prototype fabrication plan is presented along with steady and transient thermal models to verify performance of the integrated heatsink. A representative design is shown to have a steady state thermal resistivity of less than 0.4 cm(2)K/W, with the convective rate of the cooling fluid being the dominant factor. Transient analysis shows peak temperature suppression due to the effect of phase change heat absorption, including a 4 degrees C reduction under a pulsed loading condition. C1 [Jankowski, Nicholas R.; Morgan, Brian C.] USA, Res Lab, Adelphi, MD USA. RP Jankowski, NR (reprint author), USA, Res Lab, Adelphi, MD USA. EM Nicholas.jankowski@us.army.mil; brian.morgan6@us.army.mil; mcclupa@umd.edu NR 28 TC 0 Z9 0 U1 1 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4378-9 PY 2010 BP 75 EP 84 PG 10 WC Engineering, Electrical & Electronic; Engineering, Mechanical SC Engineering GA BQZ38 UT WOS:000282196300012 ER PT B AU Billie, JS Kincaid, RK AF Billie, J. Scott Kincaid, Rex K. BE Baralt, J Callaos, N Chu, HW Savoie, MJ Zinn, CD TI Analyzing Historical Changes in the Airline Transportation Network from the 1920's to Present Day SO IMCIC 2010: INTERNATIONAL MULTI-CONFERENCE ON COMPLEXITY, INFORMATICS AND CYBERNETICS, VOL I (POST-CONFERENCE EDITION) LA English DT Proceedings Paper CT International Multi-Conference on Complexity, Informatics and Cybernetics CY APR 06-09, 2010 CL Orlando, FL SP Int Inst Informat & Syst DE Airline Transportation Network; Scale-free Networks; and Geo-spatial Network Representation AB This research effort considers air transport network design as a complex systems optimization problem. Specifically, a top-down approach is taken to identify design metrics associated with scale-free networks that directly impact Federal Aviation Agency and passenger performance metrics. A historical review of the U.S. airline industry illuminates fundamental changes within the air transport network structure. The effects of changing network metrics (connectivity, synchronicity, etc) through basic network design (direct flights verses hub-and-spoke, etc.) and how criteria such as late arrivals and customer satisfaction are impacted will be examined. C1 [Billie, J. Scott] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. [Kincaid, Rex K.] Coll William & Mary, Dept Math, Williamsburg, VA 23188 USA. RP Billie, JS (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. NR 36 TC 0 Z9 0 U1 0 U2 0 PU INT INST INFORMATICS & SYSTEMICS PI ORLANDO PA 14269 LORD BARCLAY DR, ORLANDO, FL 32837 USA BN 978-1-934272-91-6 PY 2010 BP 85 EP 90 PG 6 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA BG7KY UT WOS:000391415900016 ER PT B AU Anderson, TW Clark, NA Kotz, WE Stremick, BD Arnas, O Tamm, G Ingold, K Kiel, T AF Anderson, Thomas W. Clark, Nathaniel A. Kotz, Wesley E. Stremick, Briana D. Arnas, Oezer Tamm, Gunnar Ingold, Kirk Kiel, Thomas GP ASME TI IMPROVING TURRET CONTROL ON MILITARY VEHICLES SO IMECE 2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 10, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME AB Recent additions of armor have made light tactical vehicle turrets heavy enough that mechanical assistance is required for them to rotate. The Army's solution is the Battery Powered Motorized Traversing Unit (BPMTU) which uses a joystick to traverse the turret. Use of the joystick distracts the gunner and prevents the gunner from continuously engaging the target while rotating the turret. This paper presents a modification to the weapon mount that allows the turret to be controlled by the position of the weapon itself and emphasizes the design process used to develop the inovation. With this design, the gunner can now maintain contact with a target, while rotating the turret, without fiddling with the joystick. The Weapon Activated and Controlled Turret (WACT) consists of two primary components; the bottom component is stationary relative to the turret and contains a Hall effect sensor and the top component rotates with the weapon and holds a linear magnet. As the position of the sensor relative to the magnet changes, the corresponding strength of the magnetic field also varies. This change in magnetic force induces a similar response in the output voltage of the Hall effect sensor, effectively translating rotational motion into an electric signal able to control the turret motor. C1 [Anderson, Thomas W.; Clark, Nathaniel A.; Kotz, Wesley E.; Stremick, Briana D.; Arnas, Oezer; Tamm, Gunnar] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. RP Anderson, TW (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA. NR 8 TC 0 Z9 0 U1 0 U2 4 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4383-3 PY 2010 BP 163 EP 169 PG 7 WC Automation & Control Systems; Engineering, Mechanical SC Automation & Control Systems; Engineering GA BPX13 UT WOS:000280200700021 ER PT B AU Chung, JH Coleman, NP Cheung, YS AF Chung, Jae H. Coleman, Norman P. Cheung, Yushing GP ASME TI SEMI-AUTONOMOUS CONTROL OF A MULTI-ARM TELEMANIPULATOR WITH ADAPTIVE IMPEDANCE SO IMECE 2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 10, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME ID TELEOPERATION AB This paper addresses problems to achieve transparency and contact stability for Single Master Multi-Slave telemanipulation that consists of unconstrained and constrained motions. The adaptive bilateral control with a local force compensator is developed based on adaptive impedance control and contact force driven compensation with auto-switching functions. With a limited amount of knowledge about robotic and environment dynamics and a time-varying communication delay, the developed method guarantees good adaptive tracking performance in unconstrained motion and reduction of oscillating contacts to keep a balance of the system in constrained motion. Based on an actual haptic device and virtual robots, haptic simulations are presented to demonstrate adaptive transparency and contact stability in the presence of communication delays. C1 [Chung, Jae H.; Coleman, Norman P.] US Army RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Chung, JH (reprint author), US Army RDECOM ARDEC, Bldg 95N, Picatinny Arsenal, NJ 07806 USA. EM jae.chung3@us.army.mil; jae.chung3@us.army.mil; Yu-Shing.Cheung@stevens.edu NR 16 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4383-3 PY 2010 BP 171 EP 180 PG 10 WC Automation & Control Systems; Engineering, Mechanical SC Automation & Control Systems; Engineering GA BPX13 UT WOS:000280200700022 ER PT B AU Bartolucci, SF Mago, G Gevgilili, H Vural, S Dikovics, K Kalyon, DM Fisher, FT AF Bartolucci, Stephen F. Mago, Gaurav Gevgilili, Halil Vural, Seda Dikovics, Kimberly Kalyon, Dilhan M. Fisher, Frank T. GP ASME TI INVESTIGATION OF THE PROPERTIES OF PEEK-NANOTUBE COMPOSITES PREPARED BY SOLUTION METHODS SO IMECE 2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 12, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME DE Poly(ether ether ketone); carbon nanofibers; nanocomposites ID POLY(ETHER ETHER KETONE); INDUCED CRYSTALLIZATION; CARBON NANOTUBES; NANOCOMPOSITES; MORPHOLOGY; BEHAVIOR AB Poly(ether ether ketone) (PEEK) is an aromatic, very high temperature semi-crystalline polymer which exhibits a technologically useful combination of mechanical and chemical properties. In this study carbon nanofibers (CNFs) were used to prepare nanocomposites from PEEK using a polymer crystallization technique at intermediate temperatures. The solution processing technique was used to uniformly disperse the CNFs in the polymer solution and to prepare the nanocomposite samples with different loading of CNFs. Microstructural characterization shows dispersion at very low loading of CNFs, but agglomerates were formed at higher loading. Thermal analysis was used as a means to understand the effect of CNFs on the physical properties of the PEEK nanocomposites. C1 [Bartolucci, Stephen F.] USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. RP Bartolucci, SF (reprint author), USA, Benet Labs, Armaments Res Dev & Engn Ctr, Watervliet, NY 12189 USA. EM stephen.bartolucci@us.army.mil; fgaurav@stevens.edu; Dilhan.Kalyon@stevens.edu; Frank.Fisher@stevens.edu RI mago, gaurav/A-6753-2013; Mago, Gaurav/I-3356-2013 OI mago, gaurav/0000-0003-2316-8458; NR 13 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4385-7 PY 2010 BP 279 EP 282 PG 4 WC Engineering, Mechanical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BPX18 UT WOS:000280203700040 ER PT B AU Haynes, A Gouma, P AF Haynes, A. Gouma, P. GP ASME TI NANOENGINEERING POLYANILINE FOR ADVANCED CHEMOSENSING APPLICATIONS SO IMECE 2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 12, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME ID CELLULOSE-ACETATE; TRANSPORT-PROPERTIES; MEMBRANES; BLENDS; WATER; LEUCOEMERALDINE; CONDUCTIVITY; COMPOSITES; EMERALDINE; ESTERS AB The focus of this study is the development of polyaniline based hybrid systems for selective room temperature detection of NO(2). The electrospinning technique has been employed to produce highly dispersed nanocomposites of leucoemeraldine base polyaniline (LEB-PANI) with cellulose acetate (CA) as a secondary component. The nanocomposites exhibit sensitivity and selectivity to NO(2) down to 1 ppm with response time of 70s and recovery time of 155s. Spectroscopic analyses of the nanocomposites reveal that the molecular interactions between cellulose acetate and LEB-PANI yields enhanced sensitivity and selectivity to NO(2). DC electrical resistance measurements of the composite during exposure to the analyte suggest that the response mechanism has some dependency on the humidity level in the gas chamber. This is found to be partly attributed to the byproduct of hydrolyzed CA: acetic acid. Infrared spectroscopy reveals that the acetate ions from the acid and polymer transforms base groups of LED-PANT to higher oxidized states and affix to quinoid, benzenoid, and imine groups along polyaniline's chain. These sites operate as additional reactions sites along the polymer backbone for increased ion mobility and aid in retaining the sensor's stability and selectivity under varying gas atmospheres. This paper details the results from sensing experimentation and classical characterization techniques in an effort to develop a paradigm for chemical sensing with CA-PANI nanocomposites. C1 [Haynes, A.] USA, ARDEC RDAR MEF E, Picatinny Arsenal, NJ 07806 USA. RP Haynes, A (reprint author), USA, ARDEC RDAR MEF E, Bldg,94 Picatinny Arsenal, Picatinny Arsenal, NJ 07806 USA. EM aisha.s.haynese@us.army.mil; pgouma@notes.cc.sunysb.edu NR 24 TC 0 Z9 0 U1 1 U2 5 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4385-7 PY 2010 BP 829 EP 838 PG 10 WC Engineering, Mechanical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BPX18 UT WOS:000280203700134 ER PT B AU Macri, MF AF Macri, Michael F. GP ASME TI A Comparison of coupling molecular dynamics to general finite elements SO IMECE 2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 12, PTS A AND B LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME ID SOLIDS AB In this paper, we assess the ability of three interpolation functions in a discretized continuum model to capture and accurately represent the solution. In particular we examine the differences between the partition of unity, moving least squares and finite element methods in the continuum part of the multiscale model. C1 USA, Res Dev & Engn Command, Bent Labs, Watervliet, NY 12189 USA. RP Macri, MF (reprint author), USA, Res Dev & Engn Command, Bent Labs, BLDG 115 RDAR WSB LB, Watervliet, NY 12189 USA. EM michael.f.macri@us.army.mil NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4385-7 PY 2010 BP 849 EP 852 PG 4 WC Engineering, Mechanical; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BPX18 UT WOS:000280203700137 ER PT B AU Paquin, JD Martinez, FJ Hitt, J Arnas, AO AF Paquin, Jeremy D. Martinez, Francisco J. Hitt, Joseph Arnas, A. Oezer GP ASME TI MATERIALS CONSIDERATIONS FOR IMPROVED FLASH/FLAME PROTECTION SO IMECE2009: PROCEEDINGS OF THE ASME INTERNATIONAL MECHANICAL ENGINEERING CONGRESS AND EXPOSITION, VOL 2 LA English DT Proceedings Paper CT ASME International Mechanical Engineering Congress and Exposition CY NOV 13-19, 2009 CL Lake Buena Vista, FL SP ASME AB To investigate the capabilities of protective clothing materials to withstand the initial radiant energy effects and secondary flame impingement from a blast and devise suggestions for new materials, better configuration designs, and manufacturability of those designs must be considered. This paper discusses results that will directly benefit soldiers and others with risk to exposure of flash/flames due to explosions. Dismounted soldiers need a material that has improved flash/flame protective qualities to better protect them in combat situations that may result in burn injuries from fires that originate from a blast. This paper investigates why the burns occurred, how the materials used in the current configuration of clothing could be improved upon, and what new materials choices can be made in other configurations to better protect dismounted soldiers. The causes of failure have been evaluated, and by way of reverse and forward engineering, alternative choice of materials and improved designs has been considered. As a result, a prototype can/will be built based on the design characteristics, tested, and potentially fielded for use by soldiers. The paper provides sufficient background information on the anatomy of explosions, physiology of burn injuries, and blast type and burn relationships. Current testing methods for testing burn-protection materials are discussed including both bench scales and full scale tests and the pros and cons of each. The engineering requirements for current fire resistant clothing are broken down. Then, a description of the assumptions is listed, and the engineering design process is applied to the problem to determine which characteristics are most important in this type of fire-resistant material. This process includes a survey and several design tools to narrow the design criteria to the most important engineering characteristics required for a successful application of the design. Another aspect is introduced by including an analysis of the heat transfer characteristics of fire-resistant materials to help narrow the criteria and better understand the problem. C1 [Paquin, Jeremy D.; Hitt, Joseph; Arnas, A. Oezer] US Mil Acad, West Point, NY 10996 USA. RP Paquin, JD (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 22 TC 0 Z9 0 U1 0 U2 3 PU AMER SOC MECHANICAL ENGINEERS PI NEW YORK PA THREE PARK AVENUE, NEW YORK, NY 10016-5990 USA BN 978-0-7918-4375-8 PY 2010 BP 195 EP 205 PG 11 WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Engineering, Mechanical SC Biotechnology & Applied Microbiology; Engineering GA BRC33 UT WOS:000282340500033 ER PT B AU Quinn, MJ AF Quinn, Michael J., Jr. BE ElNemr, A TI AVIAN IMMUNOTOXICOLOGY: CURRENT TRENDS AND FUTURE DIRECTIONS SO IMPACT, MONITORING AND MANAGEMENT OF ENVIRONMENTAL POLLUTION SE Pollution Science Technology and Abatement LA English DT Article; Book Chapter ID SMYTH LINE CHICKENS; BLACK-HEADED GULLS; JAPANESE-QUAIL; IMMUNE-RESPONSE; DEVELOPMENTAL IMMUNOTOXICITY; HUMORAL IMMUNITY; ANTIBODY-RESPONSE; GONADAL-STEROIDS; RISK-ASSESSMENT; BROILER CHICKS AB Immunotoxicology is a relatively recent subdiscipline of the larger field of toxicology with the majority of its studies focused on mammalian systems. Immunotoxicological studies that concentrate on avian species have steadily increased over the past two decades. Birds occupy a wide variety of ecological niches and are good representatives of many different trophic levels, making them good indicators for environmental health assessments. This review describes current methods that are commonly used to assess immune status in birds and suggests directions for future efforts. The usefulness of measures that assess the effects of environmental contaminant exposure on immunological structure will be compared to those that test function. Particular attention is paid to emerging issues in the field, such as developmental immunotoxicology (DIT) and the use of cytokine measures in immunotoxicity evaluations, and how they are being, or should be, addressed in avian species. C1 [Quinn, Michael J., Jr.] USA, Ctr Hlth Promot & Prevent Med, Directorate Toxicol, Hlth Effects Res Program, Washington, DC USA. RP Quinn, MJ (reprint author), Edgewood Area,Bldg E-2100, Aberdeen Proving Ground, MD 21010 USA. EM Michael.james.quinn@us.army.mil NR 70 TC 0 Z9 0 U1 0 U2 1 PU NOVA SCIENCE PUBLISHERS, INC PI HAUPPAUGE PA 400 OSER AVE, STE 1600, HAUPPAUGE, NY 11788-3635 USA BN 978-1-60876-487-7 J9 POLLUT SCI TECHNOL A PY 2010 BP 97 EP 113 PG 17 WC Environmental Sciences SC Environmental Sciences & Ecology GA BTD36 UT WOS:000286537000005 ER PT S AU Lepparanta, M AF Lepparanta, Matti BE George, G TI Modelling the Formation and Decay of Lake Ice SO IMPACT OF CLIMATE CHANGE ON EUROPEAN LAKES SE Aquatic Ecology Series LA English DT Article; Book Chapter ID SNOW ICE; SEA-ICE; THICKNESS; DYNAMICS; GROWTH C1 [Lepparanta, Matti] Univ Helsinki, Dept Phys, FI-00014 Helsinki, Finland. [Lepparanta, Matti] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Lepparanta, Matti] Hokkaido Univ, Inst Low Temp Sci, Sapporo, Hokkaido 060, Japan. EM matti.lepparanta@helsinki.fi NR 32 TC 13 Z9 13 U1 0 U2 4 PU ELSEVIER ACADEMIC PRESS INC PI SAN DIEGO PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA SN 1573-4595 BN 978-90-481-2944-7 J9 AQUAT ECOL SER JI Aquat. Ecol. Ser. PY 2010 BP 63 EP 83 DI 10.1007/978-90-481-2945-4_5 D2 10.1007/978-90-481-2945-4 PG 21 WC Ecology; Environmental Sciences; Marine & Freshwater Biology; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Meteorology & Atmospheric Sciences GA BNH50 UT WOS:000274567000005 ER PT J AU Burgess, AP AF Burgess, Anthony P. BE Green, A Stankosky, M Vandergriff, L TI From the Periphery to the Core: Understanding the Process Whereby Members of a Distributed Community of Practice Become Leaders of the Community (and What the Experience Means to Them) SO IN SEARCH OF KNOWLEDGE MANAGEMENT: PURSUING PRIMARY PRINCIPLES LA English DT Article; Book Chapter AB The core-group phenomenon in a distributed community of practice is the development of a small, socially connected and committed group of members that takes responsibility for the majority of activity in the system. The success of the larger community is contingent upon the vitality of the core group. Previous research has been limited largely to naming the phenomenon and establishing a relationship between the core group and the effectiveness of the community of practice. The purpose of this study was to provide a greater understanding of the core-group phenomenon by studying the lived experience of actual core-group members in one particular community of practice: a distributed community of company commanders in the U.S. Army. This research took an inductive, phenomenological approach and created insights based on multiple in-depth interviews of 10 core-group members. The study explored the process whereby members of the core group traveled from the periphery of the community to the core and what their experiences mean to them. The process was found to be an iterative, mutually reinforcing process of participation and connection. A key finding was that core-group-members' experiences are meaningful in particular ways, and the meaningful nature of the experience reinforces their participation. Analysis yielded a definition for meaningful action in a community of practice, which builds on the work of Podolny et al. (2005): An action, situated in the purposeful context of the community of practice, is meaningful to me when I make a tangible contribution to a valued other and/or the community (to contribute); I become more socially connected and achieve greater solidarity with other members (to connect); and I become more personally effective (to develop personally). Finally, this research found that a definition for leadership in communities of practice should position leadership as a process whereby members foster the creation of meaning for each other. This study contributes to the growing field of communities of practice by providing an empirically grounded understanding of the core-group phenomenon. C1 US Mil Acad, West Point, NY 10996 USA. RP Burgess, AP (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 36 TC 0 Z9 0 U1 0 U2 1 PU EMERALD GROUP PUBLISHING LIMITED PI BINGLEY PA HOWARD HOUSE, WAGON LANE, BINGLEY, W YORKSHIRE BD16 1WA, ENGLAND BN 978-1-84950-673-1 PY 2010 BP 287 EP 331 PG 45 WC Management SC Business & Economics GA BUW60 UT WOS:000290523500022 ER PT S AU Dolan, P Szu, H AF Dolan, Patrick Szu, Harold BE Szu, HH Agee, FJ TI Can we detect influenza? SO INDEPENDENT COMPONENT ANALYSES, WAVELETS, NEURAL NETWORKS, BIOSYSTEMS, AND NANOENGINEERING VIII SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII CY APR 07-09, 2010 CL Orlando, FL SP SPIE DE Surface Enhanced Raman Spectroscopy; Influenza; Disease Detection; Nanotechnology; Medicine AB This paper will give background information on the structure of different influenza viruses and address the remote detection of viral particles using Surface Enhanced Raman Spectroscopy (SERS). Also, we will mathematically predict how small to create the silver nanorods, measured by the diameter of the rod, in order for there to be a discernable enhancement in the Raman signal due to quantum properties of the rods. Finally, the future of nanotechnology in optics as it relates to medical applications will be addressed, highlighting a few of the most important possible future applications. C1 [Dolan, Patrick; Szu, Harold] USA, NVESD, MSD HSE, Ft Belvoir, VA 22060 USA. RP Dolan, P (reprint author), USA, NVESD, MSD HSE, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. NR 7 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8167-2 J9 P SOC PHOTO-OPT INS PY 2010 VL 7703 AR 77030T DI 10.1117/12.853652 PG 10 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Mathematical & Computational Biology; Nanoscience & Nanotechnology; Optics SC Computer Science; Engineering; Mathematical & Computational Biology; Science & Technology - Other Topics; Optics GA BSS75 UT WOS:000285715600026 ER PT S AU Farley, M Szu, H Reynolds, JP AF Farley, Matthew Szu, Harold Reynolds, Joseph P. BE Szu, HH Agee, FJ TI Optical determination of cardiovascular health at a distance SO INDEPENDENT COMPONENT ANALYSES, WAVELETS, NEURAL NETWORKS, BIOSYSTEMS, AND NANOENGINEERING VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII CY APR 07-09, 2010 CL Orlando, FL SP SPIE DE Laser Speckle Contrast Imaging; Blood Pressure; Pulse Wave Velocity (PWV); Laser Speckle Contrast Analysis (LASCA); Laser Speckle Imaging (LSI) ID CONTRAST ANALYSIS LASCA; CAPILLARY BLOOD-FLOW; PULSE-WAVE VELOCITY; LASER; TIME AB Although contemporary, contact methods of measuring cardiovascular health are accurate and applicable, a non-contact optical sensor that detects these same parameters of health and eliminates the inconvenience of patient contact would be useful to the medical community. Techniques of mapping and imaging blood flow with laser speckle contrast imaging have shown promise as a non-contact health sensor. This paper explores using a laser speckle detector to detect blood pressure, pulse pressure waves, and pulse wave velocity at a standoff. The laser speckle detector was able to detect pulse pressure waves and with further development, may be able to measure pulse wave velocity and blood pressure. C1 [Farley, Matthew; Szu, Harold; Reynolds, Joseph P.] USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Farley, M (reprint author), USA, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8167-2 J9 PROC SPIE PY 2010 VL 7703 AR 77030R DI 10.1117/12.853314 PG 13 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Mathematical & Computational Biology; Nanoscience & Nanotechnology; Optics SC Computer Science; Engineering; Mathematical & Computational Biology; Science & Technology - Other Topics; Optics GA BSS75 UT WOS:000285715600024 ER PT S AU Jenkins, J Szu, H AF Jenkins, Jeffrey Szu, Harold BE Szu, HH Agee, FJ TI Recognizing Foreground - Background Interaction SO INDEPENDENT COMPONENT ANALYSES, WAVELETS, NEURAL NETWORKS, BIOSYSTEMS, AND NANOENGINEERING VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII CY APR 07-09, 2010 CL Orlando, FL SP SPIE DE Early Vision; Neural Networks; Thermodynamics; Wavelets; Unsupervised Smart Sensors; Human Visual System; Retinal Ganglion Cells; Psychophysics; Neuroscience; Phase Transition; Psychology ID RETINA; INTEGRATION; ATTENTION; VISION; CELLS AB Can the background affect a foreground target in distant, low-quality imagery? If it does, it might occur in our mind, or perhaps it may represent a snapshot of our early vision. An affirmative answer, one way or another, may affect our current understanding of this phenomena and potentially for related applications. How can we be sure about this in the psychophysical sense? We begin with the physiology of our brain's homeostasis, of which an isothermal equilibrium is characterized by the minimum of Helmholtz isothermal Free Energy: A = U - T0S >= 0, where T-0 = 37 degrees C, the Boltzmann Entropy S = KBIn(W), and U is the unknown internal energy to be computed. We assume that a pre-attentive recognition is effortless, meaning A approximate to 0 implying U = T0S, Q. E. D. We estimate the early brain vision processing space to be proportional to the size of a digital image. To illustrate the importance of foreground and background interaction by the thermodynamics principle, we further approximate a distant panoramic view of low-quality night vision imagery, in terms of sparse binary macro-pixel features of connected ones and zeros. Then, to estimate the brain energy U = T0S consumed in the early vision, we shall compute the entropy of the image. According to Boltzmann, the entropy is a logarithmic function of the phase space W, which are the combinatorial choices to realize the macroscopic condition. We have obtained W proportional to N!/(P-0!P-1!P-2!...), where the total number of macro-pixels N = P-0+P-1+P-2+ for the i(th) class of macro-pixels (i = 0, 1, 2, respectively for zero, single ones, paired ones). Besides occlusion, a natural physical interaction is shadowing, which when viewed, may form paired macro-pixels; ones from the foreground while others are from the background. By computing the entropy reduction due to shadowing which creates a new class of macro-pixels, e. g. edge elements, entropy is decreased as given a constant total number of pixels N, the number of classes, P-i, increases in the denominator of W = N!/(P-0!P-1!P-2!..).. We have explicitly computed the entropy and demonstrated indeed that the existence of a physical interaction between foreground and background reduces the thermodynamic energy consumed for early vision. Furthermore, we theorized "aha" could be due to the interaction between background and foreground happening at effortless early vision minimum free energy. Therefore, we mathematically map the well-known physiology "Ganglion response function," namely the Hubel-Wiesel early vision edge map, DoG Laplacian paradigm, or Mexican hat wavelets, into two parameters: (i) the contrast between the foreground ( F) and the background ( B): -2 <= alpha I-F - I-B/(I) over bar <= 2, where the mean intensity (I) over bar = I-F - I-B/2 gives the extra factor 2; as well as (ii) the celebrated Herman Haken phase transition base on a nonlinear Hooke's spring constant beta > 0. As a result, we have also proved that disambiguated vision can happen as an instantaneous phase transition without invoking associative memory at the Hippocampus. It seems that this phase transition happens at the early vision of our retinas, then by the LGN, where both optic nerves converge in the middle of brain. We have demonstrated the effortless phenomenon of an "aha" discovery may happen at this early visual stage, rather than the conventionl EEG confirmed " event evoked potential" P300 (meaning: 300 ms=0.3 second time spent of neuro-response across the whole brain). A realistic neuropsychology vision experimentation should be conducted based on available high-resolution EEG devices (in non-interference fashion utilizing a wireless head-mount baseball cap) to determine exactly where the " see-no-see" response happen in the brain, and whether it is ahead of the P300 event or not. Without IRB for EEG human subjects, therefore, a preliminary non-invasive vision test has explored with encouraging results through an Internet based delivery system. C1 [Jenkins, Jeffrey; Szu, Harold] USA, NVESD, Ft Belvoir, VA 22060 USA. RP Jenkins, J (reprint author), USA, NVESD, Ft Belvoir, VA 22060 USA. NR 20 TC 0 Z9 0 U1 0 U2 3 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8167-2 J9 PROC SPIE PY 2010 VL 7703 AR 770312 DI 10.1117/12.853601 PG 21 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Mathematical & Computational Biology; Nanoscience & Nanotechnology; Optics SC Computer Science; Engineering; Mathematical & Computational Biology; Science & Technology - Other Topics; Optics GA BSS75 UT WOS:000285715600034 ER PT S AU Szu, H AF Szu, Harold BE Szu, HH Agee, FJ TI Nano-Photonics: past and present SO INDEPENDENT COMPONENT ANALYSES, WAVELETS, NEURAL NETWORKS, BIOSYSTEMS, AND NANOENGINEERING VIII SE Proceedings of SPIE LA English DT Proceedings Paper CT Conference on Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII CY APR 07-09, 2010 CL Orlando, FL SP SPIE AB Nanotech is at the scale of 10(-9) meters, located at the mesocopic transition phase, which can take both classical mechanics (CM) and quantum mechanics (QM) descriptions bridging ten orders of magnitude phenomena, between the microscopic world of a single atom at 10(-10) meters with the macroscopic world at meters. However, QM principles aid the understanding of any unusual property at the nanotech level. The other major difference between nano-photonics and other forms of optics is that the nano-scale is not very 'hands on'. For the most part, we will not be able to see the components with our naked eyes, but will be required to use some nanotech imaging tools, as follows: (1) Electron Scanning Microscope (through a focusing lens of positive refractive index material). (2) Scanning Tunneling Microscope (STM, (de Broglie Wave for dry metallic materials). (3) X-ray Laser Photons: Specifically, Los Alamos Lab has produced the world record for the shortest wavelength X-ray laser for coherent imaging of atoms. (4) Nature photonics is an inspiration, a proof of existence in nano-scales: e. g. reflection-free glare-less Moth's eye, dirt-free lily flower emerging from a muddy pond, sucking setae of scalping gecko, etc. (5) Evanescence Wave Imaging: the detail evanescence decaying waves become a propagating imaging focusing wave in case of a negative dielectric constant, such as made possible at the anisotropic dielectric material which might produce a negative transversal index epsilon(2)(perpendicular to)=parallel to epsilon(o)parallel to(2)-epsilon(2)(parallel to); or the optical surface optical Plasmon reactive interaction, or man-made slit ring :"letter C" at the long-long infrared at hundreds THz complex impedance. The nano-manipulator (NanoRobot) has combined both "touching-feeling" and "pushing-moving" in a design, which supports electrically multiplexing using a compounded piezoelectric cantilever layers with single crystal tips/. This manipulator is augmented with the Atomic Force Microscope (AFM), after a detailed blue-print made by STM imaging. As an application, we review (i) a simple self-consistency derivation of the Wallance's band-gap formulae for Single Wall CNT; (ii) the prototype of non-cryogenic dual infrared spectrum cameras made of the semiconductor Carbon NanoTube (CNT), and (iii) the high efficient solar voltaic cells made of a stack of rotated staircase of CNT's. C1 USA, NVESD RDECOM CERDEC, Ft Belvoir, VA 22060 USA. RP Szu, H (reprint author), USA, NVESD RDECOM CERDEC, Ft Belvoir, VA 22060 USA. NR 6 TC 0 Z9 0 U1 4 U2 18 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8167-2 J9 PROC SPIE PY 2010 VL 7703 AR 77030J DI 10.1117/12.855069 PG 14 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Mathematical & Computational Biology; Nanoscience & Nanotechnology; Optics SC Computer Science; Engineering; Mathematical & Computational Biology; Science & Technology - Other Topics; Optics GA BSS75 UT WOS:000285715600017 ER PT S AU Szu, H AF Szu, Harold BE Szu, HH Agee, FJ TI ASYMMETRIC GT OF SOCIAL NETWORKS SO INDEPENDENT COMPONENT ANALYSES, WAVELETS, NEURAL NETWORKS, BIOSYSTEMS, AND NANOENGINEERING VIII SE Proceedings of SPIE-The International Society for Optical Engineering LA English DT Proceedings Paper CT Conference on Independent Component Analyses, Wavelets, Neural Networks, Biosystems, and Nanoengineering VIII CY APR 07-09, 2010 CL Orlando, FL SP SPIE DE Graph Laplacian; Asymmetric Weight; Social Networkworks; Kirchhoff Free Energy; Average Centrality AB Web citation indexes are computed according to a data vector collected from the frequency of user accesses, citations weighted by other sites' popularities, and modified by the financial sponsorship in a proprietary manner. The indexing determining the information to be retrieved by the public should be made responsible transparently in at least two ways. One shall balance the inbound linkages pointed at the specific i-th site called the popularity (P(i)equivalent to Sigma(N)(j=1)W(i,j)) with the outbound linkages (R(i) equivalent to Sigma(N)(K=1)W(k,i)) called the risk factor before the release of new information as environmental impact analysis. The relationship between these two factors cannot be assumed equivalent (undirected) as in the case of many mainstream Graph Theory (GT) models. The measure over the edge is the asymmetric weight: [GRAPHICS] where [GRAPHICS] are either a-priori or a-posterior probabilities and the mutual coupling [GRAPHICS] . All ten social fabrics are analyzable in such a asymmetric framework in terms of the thermodynamic free energy defined by Kirchhoff as [GRAPHICS] where [< d(i) > delta(ij) - W(i,j)] with new averaged centrality [GRAPHICS] .Applications have two categories:(A) Symmetric GT: (i) i-phone video stream organization. One can apply a symmetric diffusion w(ij) = exp -vertical bar x(i)-x(j)/2 sigma vertical bar = W(ji) where < d(i) >-> d equivalent to Sigma(N)(j-1) W(i,j) and [K(i,j)] -> [L(ij)] equivalent to [d(i)delta(ij) - W(ij)] which becomes symmetric GT Laplacian mapping images [GRAPHICS] to low dimensional optical flow. (ii) Database Management: If one can decompose the social group to two closely networkted social groups to partition the storage into two separate ones. (B) Asymmetric GT: (iii) Non-orthogonal projection: [GRAPHICS] where [GRAPHICS] give rise to a pseudo-projection operator generating unequal membership ground state. The next eigenvector can be used to assess the information impact factor in trading the popularity against the risk before the release. (iv) WebSite Trustworthiness: tracking the change of the degree of asymmetry: [GRAPHICS] might signal a warning with learning. C1 USA, NVESD RDECOM CERDEC, Ft Belvoir, VA 22060 USA. RP Szu, H (reprint author), USA, NVESD RDECOM CERDEC, Ft Belvoir, VA 22060 USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU SPIE-INT SOC OPTICAL ENGINEERING PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA SN 0277-786X BN 978-0-8194-8167-2 J9 P SOC PHOTO-OPT INS PY 2010 VL 7703 AR 770304 DI 10.1117/12.853682 PG 17 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Mathematical & Computational Biology; Nanoscience & Nanotechnology; Optics SC Computer Science; Engineering; Mathematical & Computational Biology; Science & Technology - Other Topics; Optics GA BSS75 UT WOS:000285715600003 ER PT B AU Li, RCL Unguris, J Edelstein, AS Burnette, JE Fischer, GA Nowak, ER Egelhoff, WF Pong, PWT AF Li, Ronald C. L. Unguris, J. Edelstein, Alan S. Burnette, J. E. Fischer, G. A. Nowak, Edmund R. Egelhoff, William F., Jr. Pong, Philip W. T. BE Chu, PKI TI Magnetic Tunnel Junction Magnetic Field Sensor Design Tool SO INEC: 2010 3RD INTERNATIONAL NANOELECTRONICS CONFERENCE, VOLS 1 AND 2 LA English DT Proceedings Paper CT 3rd IEEE International NanoElectronics Conference (INEC)/Symposium on Nanoscience and Nanotechnology in China CY JAN 03-08, 2010 CL City Univ Hong Kong, Hong Kong, PEOPLES R CHINA SP IEEE HO City Univ Hong Kong AB A spreadsheet-based magnetic tunnel junction (MTJ) sensor design tool is presented in this paper. The system is developed using Excel and Visual Basic Application. It allows users to optimize the various parameters of the sensor design with the goal of SQUID-like sensitivity. Users can input parameters of the design including magnetic properties, junction areas, and free layers thicknesses. The design tool will then calculate and display automatically various noise sources including Johnson noise, shot noise, 1/f noise, and thermal magnetic noise that must be considered when building MTJ magnetic field sensors. Graphs predicting the sensitivities, operating current and power of the finished sensors are shown and fine tuning of each design parameter is allowed using the scrollbars provided. Using this design tool, effects of changes made to any design parameter can be clearly observed and detailed noise analysis can be studied without manually repeating complex calculations. C1 [Li, Ronald C. L.; Pong, Philip W. T.] Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China. [Unguris, J.] NIST, Ctr Nanoscale Sci & Tech, Gaithersburg, MD 20899 USA. [Edelstein, Alan S.; Burnette, J. E.; Fischer, G. A.] Army Res Lab, Adelphi, MD 20783 USA. [Nowak, Edmund R.] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Egelhoff, William F., Jr.] NIST, Div Met, Gaithersburg, MD 20899 USA. RP Li, RCL (reprint author), Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China. EM ppong@eee.hku.hk RI Unguris, John/J-3989-2014 NR 6 TC 1 Z9 1 U1 0 U2 2 PU IEEE PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 USA BN 978-1-4244-3543-2 PY 2010 BP 1149 EP + PG 2 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology SC Engineering; Science & Technology - Other Topics GA BQW82 UT WOS:000282026500585 ER PT J AU Burtnick, MN DeShazer, D Nair, V Gherardini, FC Brett, PJ AF Burtnick, Mary N. DeShazer, David Nair, Vinod Gherardini, Frank C. Brett, Paul J. TI Burkholderia mallei Cluster 1 Type VI Secretion Mutants Exhibit Growth and Actin Polymerization Defects in RAW 264.7 Murine Macrophages SO INFECTION AND IMMUNITY LA English DT Article ID FRANCISELLA PATHOGENICITY ISLAND; VIRULENCE DETERMINANT; SALMONELLA-ENTERICA; RESPONSE REGULATOR; EDWARDSIELLA-TARDA; EUKARYOTIC CELLS; IN-VIVO; SYSTEM; PSEUDOMALLEI; PROTEIN AB Burkholderia mallei is a facultative intracellular pathogen that causes severe disease in animals and humans. Recent studies have shown that the cluster 1 type VI secretion system (T6SS-1) expressed by this organism is essential for survival in a hamster model of glanders. To better understand the role of T6SS-1 in the pathogenesis of disease, studies were initiated to examine the interactions of B. mallei tssE mutants with RAW 264.7 murine macrophages. Results obtained by utilizing modified gentamicin protection assays indicated that although the tssE mutants were able to survive within RAW 264.7 cells, significant growth defects were observed in comparison to controls. In addition, analysis of infected monolayers by differential interference contrast and fluorescence microscopy demonstrated that the tssE mutants lacked the ability to induce multinucleated giant cell formation. Via the use of fluorescence microscopy, tssE mutants were shown to undergo escape from lysosome-associated membrane protein 1-positive vacuoles. Curiously, however, following entry into the cytosol, the mutants exhibited actin polymerization defects resulting in inefficient intra-and intercellular spread characteristics. Importantly, all mutant phenotypes observed in this study could be restored by complementation. Based upon these findings, it appears that T6SS-1 plays a critical role in growth and actin-based motility following uptake of B. mallei by RAW 264.7 cells. C1 [Burtnick, Mary N.; Brett, Paul J.] Univ S Alabama, Dept Microbiol & Immunol, Mobile, AL 36688 USA. [DeShazer, David] USA, Bacteriol Div, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Nair, Vinod] NIAID, Res Technol Sect, RTB, NIH, Hamilton, MT 59840 USA. [Gherardini, Frank C.] NIAID, Lab Zoonot Pathogens, Rocky Mt Labs, NIH, Hamilton, MT 59840 USA. RP Brett, PJ (reprint author), Univ S Alabama, Dept Microbiol & Immunol, 307 Univ Blvd, Mobile, AL 36688 USA. EM pbrett@jaguar1.usouthal.edu FU NIH; National Institute of Allergy and Infectious Diseases FX This research was supported in part by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases. NR 66 TC 50 Z9 50 U1 2 U2 14 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 EI 1098-5522 J9 INFECT IMMUN JI Infect. Immun. PD JAN PY 2010 VL 78 IS 1 BP 88 EP 99 DI 10.1128/IAI.00985-09 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 535QC UT WOS:000272984300008 PM 19884331 ER EF