FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Bassett, JT Veerappan, GR Lee, DH AF Bassett, John T. Veerappan, Ganesh R. Lee, Dong H. TI Glycogenic Hepatopathy: A Rare Cause of Increased Aminotransferase Levels in a Diabetic Patient SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Editorial Material C1 [Bassett, John T.; Lee, Dong H.] Natl Naval Med Ctr, Dept Gastroenterol, Bethesda, MD USA. [Veerappan, Ganesh R.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. RP Bassett, JT (reprint author), Natl Naval Med Ctr, Dept Gastroenterol, Bethesda, MD USA. NR 2 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1542-3565 J9 CLIN GASTROENTEROL H JI Clin. Gastroenterol. Hepatol. PD NOV PY 2008 VL 6 IS 11 BP XXVI EP XXVI DI 10.1016/j.cgh.2008.04.034 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 376VK UT WOS:000261210900002 PM 18691943 ER PT J AU Kramer, LC Richards, PA Thompson, AM Harper, DP Fairchok, MP AF Kramer, Lynne C. Richards, Peaches A. Thompson, Amy M. Harper, David P. Fairchok, Mary P. TI Alternating antipyretics: Antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children SO CLINICAL PEDIATRICS LA English DT Article DE fever; acetaminophen; ibuprofen; pediatric ID FEVER PHOBIA; FEBRILE CHILDREN; THERAPY; PARENTS; SAFETY; MISCONCEPTIONS AB Methods A prospective, randomized double-blind placebo control study comparing the efficacy of acetaminophen to acetaminophen alternated with ibuprofen in 38 healthy outpatient children 6 months to 6 years presenting to the outpatient clinic with fever > 38 degrees C was conducted. Temperatures were recorded at 0, 3, 4, 5, and 6 hours. Side effect diaries and parental perception of efficacy were filled out hourly by parents. Results There were no significant differences in temperature between the 2 groups at times 0, 3, and 6 hours. The alternating group had significantly lower mean temperatures at both 4 hours (38.0 degrees C vs 37.4 degrees C; P = .05) and 5 hours (37.1 degrees C vs 37.9 degrees C; P = .0032). Parents did not perceive any difference in fever control between the groups. Conclusions An alternating regimen of acetaminophen with ibuprofen significantly decreased fever at 4 and 5 hours compared with acetaminophen alone. However, parents did not perceive a difference in efficacy. C1 [Kramer, Lynne C.; Thompson, Amy M.; Fairchok, Mary P.] Madigan Army Med Ctr, Dept Pediat, Tacoma, WA 98431 USA. [Richards, Peaches A.] Weed Army Community Hosp, Ft Irwin, CA USA. [Harper, David P.] Walter Reed Army Med Ctr, Dept Pediat Hematol Oncol, Tacoma, WA USA. RP Fairchok, MP (reprint author), Madigan Army Med Ctr, Dept Pediat, Tacoma, WA 98431 USA. EM mary.fairchok@us.army.mil FU American Academy of Pediatrics FX This research was supported by a Resident Research Grant from the American Academy of Pediatrics. NR 23 TC 14 Z9 14 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD NOV PY 2008 VL 47 IS 9 BP 907 EP 911 DI 10.1177/0009922808319967 PG 5 WC Pediatrics SC Pediatrics GA 360CT UT WOS:000260035300009 PM 18539869 ER PT J AU Mahnke, CB Mulreany, MP Inafuku, J Abbas, M Feingold, B Paolillo, JA AF Mahnke, C. Becket Mulreany, Michael P. Inafuku, Jill Abbas, Mazen Feingold, Brian Paolillo, Joseph A. TI Utility of store-and-forward pediatric telecardiology evaluation in distinguishing normal from pathologic pediatric heart sounds SO CLINICAL PEDIATRICS LA English DT Article; Proceedings Paper CT Pediatric Telehealth Colloquium CY SEP, 2007 CL San Francisco, CA DE cardiology; telemedicine ID AUSCULTATION SKILLS; INITIAL EVALUATION; PARENTAL ANXIETY; MURMURS; CHILDREN; SCHOOLCHILDREN; CARDIOLOGIST; PREVALENCE; ACCURACY; DISEASE AB Because pediatric cardiologists can accurately diagnose innocent murmurs by physical exam alone, the authors developed a system for remote cardiac auscultation. They hypothesized that their system could accurately classify auscultatory findings as normal/innocent or pathologic. Patients undergoing evaluation underwent examination, echocardiography, and heart sound recording. Pediatric cardiologists evaluated the heart sounds and classified the case as either normal/innocent or pathologic. They reviewed 103 heart sound data sets; 85% of the cases were accurately classified as either normal/innocent or pathologic, with a sensitivity of 82% and specificity of 86%. However, when accounting for clinical diagnosis, reviewer uncertainty, and ECG abnormalities, the sensitivity and specificity improved to 91% and 88% (accuracy 89%), respectively. Degree of certainty with the telecardiology diagnosis correlated with correct interpretation (P < .005). Digital heart sound recordings evaluated via telemedicine can distinguish normal/innocent murmurs from pathologic ones. Such a system could improve the use of pediatric cardiology services. C1 [Mahnke, C. Becket; Mulreany, Michael P.; Inafuku, Jill; Abbas, Mazen] Tripler Army Med Ctr, Dept Pediat Cardiol, Honolulu, HI 96859 USA. [Feingold, Brian] UPMC, Childrens Hosp Pittsburgh, Pittsburgh, PA USA. [Paolillo, Joseph A.] Univ Florida, Gainesville, FL USA. RP Mahnke, CB (reprint author), Tripler Army Med Ctr, Dept Pediat Cardiol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Christopher.Mahnke@us.army.mil NR 23 TC 6 Z9 6 U1 0 U2 3 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD NOV PY 2008 VL 47 IS 9 BP 919 EP 925 DI 10.1177/0009922808320596 PG 7 WC Pediatrics SC Pediatrics GA 360CT UT WOS:000260035300011 PM 18626106 ER PT J AU Moseman, ER Winkler, P AF Moseman, Elizabeth R. Winkler, Peter TI On a Form of Coordinate Percolation SO COMBINATORICS PROBABILITY & COMPUTING LA English DT Article ID DEPENDENT PERCOLATION; RANDOM-WALKS AB Let a(i), b(i), i = 0, 1, 2, ... be drawn uniformly and independently from the unit interval, and let t be a fixed real number. Let a site (i, j) is an element of N(2) be open if a(i) + b(j) <= t, and closed otherwise. We obtain a simple, exact expression for the probability Theta(t) that there is an infinite path (oriented or not) of open sites, containing the origin. Theta(t) is continuous and has continuous first derivative except at the critical point (t = 1), near which it has critical exponent (3 - root 5)/2. C1 [Moseman, Elizabeth R.] USMA, Dept Math Sci, West Point, NY 10996 USA. [Winkler, Peter] Dartmouth Coll, Dept Math, Hanover, NH 03755 USA. RP Moseman, ER (reprint author), USMA, Dept Math Sci, West Point, NY 10996 USA. EM lizz.moseman@usma.edu; peter.winkler@dartmouth.edu OI Winkler, Peter/0000-0002-1259-3574 FU NSF [DMS-0600876] FX Research supported by NSF grant DMS-0600876. NR 12 TC 1 Z9 1 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0963-5483 J9 COMB PROBAB COMPUT JI Comb. Probab. Comput. PD NOV PY 2008 VL 17 IS 6 BP 837 EP 845 DI 10.1017/S0963548308009474 PG 9 WC Computer Science, Theory & Methods; Mathematics; Statistics & Probability SC Computer Science; Mathematics GA 377IR UT WOS:000261245400011 ER PT J AU Glodek, TE Boyd, SE McAninch, IM LaScala, JJ AF Glodek, Terese E. Boyd, Steven E. McAninch, Ian M. LaScala, John J. TI Properties and performance of fire resistant eco-composites using polyhedral oligomeric silsesquioxane (POSS) fire retardants SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 5th Asian/Australasian Conference on Composite Materials (ACCM-5) CY NOV 27-30, 2006 CL Hong Kong, PEOPLES R CHINA SP Hong Kong Univ Sci & Technol, Nanjing Univ Aeronaut & Astronaut, Hong Kong Polytech Univ, Univ Hong Kong DE Fire resistant eco-composites; Polymer matrix composites (PMCs); Thermo-mechanical properties; Thermal properties; Dynamic mechanical thermal analysis (DMTA) ID RESINS AB Fire retardants are combined with polymer resins to reduce their flammability, decrease production of volatiles and inhibit pyrolysis. The goal of this work is to develop environmentally friendly fire retardant vinyl ester resin composites by blending fatty acid vinyl ester (FAVE) resins with environmentally friendly particulate fire retardants: polyhedral oligomeric silesquioxanes (POSS), while comparing them to similar composites with talc, a standard inorganic filler. Various concentrations of POSS or talc filler were blended into commercial and FAVE brominated vinyl ester resins, Derakane 510A-40 and FAVE-Br, respectively, and commercial and FAVE non-brominated vinyl ester resins, Derakane 441-400 and FAVE-L, respectively. Thermo-mechanical characterization of the new eco-composites was conducted using dynamic mechanical analysis and thermo-gravimetric analysis. Most POSS additives performed no better than talc in improving the composite performance relative to that of the neat resin. Yet, composites reinforced with methacryl POSS (MA0735) slightly outperformed the other POSS additives and talc. This POSS additive maintained resin viscosity, improved T-g, increased cross-link density, and increased flame retardance. However, the flame retardance of even this relatively high performing POSS-filled composite was very poor compared to that of brominated resins and the thermo-mechanical improvements relative to talc were small. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Glodek, Terese E.; Boyd, Steven E.; McAninch, Ian M.; LaScala, John J.] USA, Dept Army, Res Lab, AMSRD ARL WM MC, Aberdeen Proving Ground, MD 21005 USA. RP Boyd, SE (reprint author), USA, Dept Army, Res Lab, AMSRD ARL WM MC, Aberdeen Proving Ground, MD 21005 USA. EM steven.e.boyd@arl.army.mil OI McAninch, Ian/0000-0002-9190-2936 NR 20 TC 22 Z9 22 U1 3 U2 21 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD NOV PY 2008 VL 68 IS 14 SI SI BP 2994 EP 3001 DI 10.1016/j.compscitech.2008.06.019 PG 8 WC Materials Science, Composites SC Materials Science GA 374BM UT WOS:000261017300024 ER PT J AU Yokota, M Berglund, L Cheuvront, S Santee, W Latzka, W Montain, S Kolka, M Moran, D AF Yokota, Miyo Berglund, Larry Cheuvront, Samuel Santee, William Latzka, William Montain, Scott Kolka, Margaret Moran, Daniel TI Thermoregulatory model to predict physiological status from ambient environment and heart rate SO COMPUTERS IN BIOLOGY AND MEDICINE LA English DT Article DE Real-time modeling; Heat stress; Heart rate; Core temperature; Air temperature ID EXERCISE; TOLERANCE; STRESS; TEMPERATURE; AFGHANISTAN; PERFORMANCE; CASUALTIES AB A real-time thermoregulatory model was developed for predicting real-time physiological responses of workers engaged in various tasks for prolonged time. The unique feature of the present model is primarily on metabolic activity inputs derived from minimum non-invasive measures (i.e.. heart rate and ambient temperature). In addition, it utilizes individual anthropological characteristics (height, weight, and clothing) as an input to estimate core temperatures (T(c)). The model was validated using data from five laboratory studies (n = 63) with varied environments, clothing, and heat acclimation status. Overall. T(c) predictions using this simplified model, corresponded well with measured values (root mean square deviation: 0.05-0.31 degrees C). Published by Elsevier Ltd. C1 [Yokota, Miyo; Berglund, Larry; Cheuvront, Samuel; Santee, William; Latzka, William; Montain, Scott; Kolka, Margaret] USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. [Moran, Daniel] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. RP Yokota, M (reprint author), USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Miyo.Yokota@US.ARMY.MIL NR 20 TC 12 Z9 12 U1 1 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-4825 J9 COMPUT BIOL MED JI Comput. Biol. Med. PD NOV-DEC PY 2008 VL 38 IS 11-12 BP 1187 EP 1193 DI 10.1016/j.compbiomed.2008.09.003 PG 7 WC Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Computer Science; Engineering; Mathematical & Computational Biology GA 386FU UT WOS:000261868500007 PM 18947825 ER PT J AU Acevedo-Hurtado, PO Sundaram, PA Caceres-Valencia, PG Fachini, ER Miller, CE Placzankis, BE AF Acevedo-Hurtado, P. O. Sundaram, P. A. Caceres-Valencia, P. G. Fachini, E. R. Miller, C. E. Placzankis, B. E. TI Characterization of atmospheric corrosion in Al/Ag lap joints SO CORROSION SCIENCE LA English DT Article DE Al/Ag lap joints; XPS, SEM; Atmospheric corrosion ID POLLUTION PARAMETERS; ALUMINUM; SILVER; ZINC; PREDICTION; NACL; CO2 AB Lap joints fabricated using Al2024T3/commercially pure Ag sheet couples with nylon fasteners were exposed to standard field tests in a tropical marine atmosphere for a total period of six months. Atmospheric conditions were recorded using a weather monitoring station. Simultaneously, samples were also exposed in a salt spray chamber according to ASTM B117 and GM 9540P standards. Corrosion data was obtained for monthly intervals for both field and laboratory samples. Weight loss, pitting characteristics and the nature of the corrosion products were evaluated. Corrosion mechanisms based on the observed atmospheric corrosion phenomena are proposed. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Acevedo-Hurtado, P. O.; Sundaram, P. A.; Caceres-Valencia, P. G.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00681 USA. [Fachini, E. R.] Univ Puerto Rico, Gen Studies Fac, Dept Phys Sci, Rio Piedras, PR 00931 USA. [Miller, C. E.; Placzankis, B. E.] USA, Res Lab, Weap & Mat Directorate, Aberdeen Proving Ground, MD 21006 USA. RP Sundaram, PA (reprint author), Univ Puerto Rico, Dept Mech Engn, POB 9045, Mayaguez, PR 00681 USA. EM psundaram@me.uprm.edu FU Mandaree Corporation [FA8501-06-D-0001] FX This study was funded by the Mandaree Corporation under Task Order FA8501-06-D-0001. Thanks are due to Dr. R.P.I. Adler, US Army Research Laboratory for valuable suggestions. The Al 2024T3 samples were provided by Dr. W.H. Abbott, Battelle Laboratories, Columbus, OH. NR 30 TC 2 Z9 2 U1 1 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-938X J9 CORROS SCI JI Corrosion Sci. PD NOV PY 2008 VL 50 IS 11 BP 3123 EP 3131 DI 10.1016/j.corsci.2008.08.014 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 378ZV UT WOS:000261364700018 ER PT J AU Weyandt, J Ellsworth, RE Hooke, JA Shriver, CD Ellsworth, DL AF Weyandt, Jamie Ellsworth, Rachel E. Hooke, Jeffrey A. Shriver, Craig D. Ellsworth, Darrell L. TI Environmental Chemicals and Breast Cancer Risk - A Structural Chemistry Perspective SO CURRENT MEDICINAL CHEMISTRY LA English DT Review DE Breast cancer; environmental pollutants; chemistry; epidemiology; organochlorine; polychlorinated biphenyls; DDT; polycyclic aromatic hydrocarbons ID HYDROCARBON-DNA ADDUCTS; POLYCYCLIC AROMATIC-HYDROCARBONS; ESTROGEN-RECEPTOR-ALPHA; DONE MEAT INTAKE; SERUM POLYCHLORINATED-BIPHENYLS; ENDOCRINE-DISRUPTING CHEMICALS; CONGENER-SPECIFIC ANALYSIS; TOXIC EQUIVALENCY FACTORS; ADIPOSE-TISSUE; HETEROCYCLIC AMINES AB In modern industrialized societies, people are exposed to thousands of naturally occurring and synthetic chemicals throughout their lifetime. Although certain occupational chemicals are known to be carcinogenic in humans, it has been difficult to definitively determine the adverse health effects of many environmental pollutants due to their tremendous chemical diversity and absence of a consistent structural motif. Many environmental chemicals are metabolized in the body to reactive intermediates that readily react with DNA to form modified bases known as adducts, while other compounds mimic the biological function of estrogen. Because environmental chemicals tend to accumulate in human tissues and have carcinogenic and/or estrogenic properties, there is heightened interest in determining whether environmental chemicals increase risk for endocrine-related cancers, including breast cancer. Breast cancer is the most common cancer in women worldwide, but established risk factors account for a relatively small proportion of cases and causative factors remain ambiguous and poorly defined. In this review, we outline the structural chemistry of environmental contaminants, describe mechanisms of carcinogenesis and molecular pathways through which these chemicals may exert detrimental health effects, review current knowledge of relationships between chemicals and breast cancer risk, and highlight future directions for research on environmental contributions to breast cancer. Improved understanding of the relationship between environmental chemicals and breast cancer will help to educate the general public about real and perceived dangers of these pollutants in our environment and has the potential to reduce individual risk by changing corporate practices and improving public health policies. C1 [Weyandt, Jamie; Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Rachel E.] Henry M Jackson Fdn Advancement Mil Med, Rockville, MD USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Gen Surg Serv, Washington, DC 20307 USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Ellsworth, DL (reprint author), Windber Res Inst, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM d.ellsworth@wriwindber.org FU United States Department of Defense [MDA W81XWH-05-2-0075] FX This work was performed under the auspices of the Clinical Breast Care Project, a joint effort of many investigators and staff members whose contributions are gratefully acknowledged. We especially thank the program participants. Figures were prepared by Debbie Ford in the Henry M. Jackson Foundation for the Advancement of Military Medicine Graphics Department. Supported by the United States Department of Defense (Military Molecular Medicine Initiative MDA W81XWH-05-2-0075). The opinion and assertions contained herein are the private views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense. NR 223 TC 12 Z9 12 U1 2 U2 19 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8673 EI 1875-533X J9 CURR MED CHEM JI Curr. Med. Chem. PD NOV PY 2008 VL 15 IS 26 BP 2680 EP 2701 DI 10.2174/092986708786242930 PG 22 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA 386OE UT WOS:000261891700004 PM 18991630 ER PT J AU Scrimgeour, AG Lukaski, HC AF Scrimgeour, Angus G. Lukaski, Henry C. TI Zinc and diarrheal disease: current status and future perspectives SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Article DE cholera; diarrhea; enterotoxigenic Escherichia coli; HIV; shigellosis; zinc ID RANDOMIZED CONTROLLED-TRIAL; HIV-1 INFECTION; PERSISTENT DIARRHEA; IMMUNE-SYSTEM; ORAL ZINC; SUPPLEMENTATION; CHILDREN; CHOLERA; BANGLADESH; DEFICIENCY AB Purpose of review To evaluate clinical data indicating the benefits of oral zinc supplementation to prevent and/or treat diarrhea in children and extend these findings to adults. Recent findings Zinc plays an important role in modulating host resistance to infectious agents and reducing the risk, severity, and duration of diarrheal diseases. Zinc is important in the developing world and in low-income and middle-income countries where mild-to-moderate zinc deficiency is highly prevalent. The WHO/UNICEF recommendations for zinc supplementation are based on meta-analyses of randomized, controlled intervention trials on children: 20 mg zinc/day for 10-14 days for children with acute diarrhea and 10 mg/day for infants under 6 months of age. Effective forms include sulfate, gluconate, or acetate. No similar studies have been conducted on adults. Thus, carefully conducted clinical trials are necessary to ascertain the efficacy of zinc in prevention of acute and persistent diarrhea in adults. Summary Faced with rising antibiotic resistance and the lack of effective antidiarrheal vaccines, oral zinc provides substantial benefit in the reduction of stool output and disease duration combined with safety, selectivity of action, and low cost. Thus, oral zinc supplementation is a practical therapeutic intervention for the treatment of diarrhea in children, and by extension, should be provided to adults. C1 [Scrimgeour, Angus G.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Lukaski, Henry C.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA. RP Scrimgeour, AG (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM angus.scrimgeour@us.army.mi NR 47 TC 19 Z9 21 U1 1 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1363-1950 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD NOV PY 2008 VL 11 IS 6 BP 711 EP 717 DI 10.1097/MCO.0b013e3283109092 PG 7 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 368KI UT WOS:000260619600006 PM 18827574 ER PT J AU Weichel, ED Colyer, MH AF Weichel, Eric D. Colyer, Marcus H. TI Combat ocular trauma and systemic injury SO CURRENT OPINION IN OPHTHALMOLOGY LA English DT Article DE closed-globe injury; combat ocular trauma; enucleation; intraocular foreign body; open-globe injury; traumatic brain injury ID EYE INJURIES; WAR INJURIES; IRAQI FREEDOM; DESERT-SHIELD; PROTECTION; MANAGEMENT; STORM AB Purpose of review To review the recent literature regarding combat ocular trauma during hostilities in Operations Iraqi Freedom and Enduring Freedom, describe the classification of combat ocular trauma, and offer strategies that may assist in the management of eye injuries. Recent findings Several recent publications have highlighted features of combat ocular trauma from Operation Iraqi Freedom. The most common cause of today's combat ocular injuries is unconventional fragmentary munitions causing significant blast injuries. These explosive munitions cause high rates of concomitant nonocular injuries such as traumatic brain injury, amputation, and other organ injuries. The most frequent ocular injuries include open-globe and adnexal lacerations. The extreme severity of combat-related open-globe injuries leads to high rates of primary enucleation and retained intraocular foreign bodies. Visual outcomes of intraocular foreign body injuries are similar to other series despite delayed removal, and no cases of endophthalmitis have occurred. Despite these advances, however, significant vision loss persists in cases of perforating globe injuries as well as open and closed-globe trauma involving the posterior segment. Summary This review summarizes the recent literature describing ocular and systemic injuries sustained during Operations Iraqi and Enduring Freedom. An emphasis on classification of ocular injuries as well as a discussion of main outcome measures and complications is discussed. C1 [Weichel, Eric D.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Weichel, Eric D.] NEI, NIH, Bethesda, MD 20892 USA. RP Weichel, ED (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM eweichel@hotmail.com NR 39 TC 24 Z9 24 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1040-8738 J9 CURR OPIN OPHTHALMOL JI Curr. Opin. Ophthalmol. PD NOV PY 2008 VL 19 IS 6 BP 519 EP 525 DI 10.1097/ICU.0b013e3283140e98 PG 7 WC Ophthalmology SC Ophthalmology GA 367WA UT WOS:000260582100011 PM 18854697 ER PT J AU Lewis, FS Xia, Y Guardiano, RA Maggio, KL AF Lewis, Felisa S. Xia, Yang Guardiano, Robert A. Maggio, Kurt L. TI What Is Your Diagnosis? The Diagnosis: Dermatofibrosarcoma Protuberans SO CUTIS LA English DT Editorial Material ID MOHS MICROGRAPHIC SURGERY C1 [Lewis, Felisa S.; Xia, Yang; Guardiano, Robert A.; Maggio, Kurt L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Lewis, FS (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD NOV PY 2008 VL 82 IS 5 BP 325 EP + PG 3 WC Dermatology SC Dermatology GA 377KQ UT WOS:000261250500004 PM 19090335 ER PT J AU Forbes, MG Doyle, RD Scott, JT Stanley, JK Huang, H Brooks, BW AF Forbes, Margaret G. Doyle, Robert D. Scott, J. Thad Stanley, Jacob K. Huang, Hui Brooks, Bryan W. TI Physical Factors Control Phytoplankton Production and Nitrogen Fixation in Eight Texas Reservoirs SO ECOSYSTEMS LA English DT Article DE N(2) fixation; primary production; reservoirs; regression trees; total phosphorus; relative drainage area ID BLUE-GREEN-ALGAE; FRESH-WATER; N-P; ACETYLENE-REDUCTION; PHOSPHORUS RATIOS; MARINE ECOSYSTEMS; NUMERICAL-MODEL; CHESAPEAKE BAY; LAKE-MICHIGAN; N-2 FIXATION AB We compared regression tree analyses and multiple linear regression models to explore the relative importance of physical factors, land use, and water quality in predicting phytoplankton production and N(2) fixation potentials at 85 locations along riverine to lacustrine gradients within eight southern reservoirs. The regression tree model (r(2) = 0.73) revealed that differences in phytoplankton production were primarily a function of water depth. The highest rates of production (mg C m(-3) h(-1)) occurred at shallow sites (< 0.9 m), where rates were also related to total phosphorus (TP) levels. At deeper sites, production rates were higher at sites with relative drainage area (RDA, ratio of drainage area to water surface area) below 45, potentially due to longer hydraulic residence times. In contrast, multiple linear regression selected TP, RDA, dissolved phosphorus, and percent developed land as significant model variables (r(2) = 0.63). The regression tree model (r(2) = 0.67) revealed that N(2) fixation potentials (mg N m(-3) h(-1)) were substantially higher at sites with relatively smaller drainage areas (RDA < 45). Within this subgroup, fixation rates were additionally related to TP values (threshold = 41 mu g I(-1)). The multiple linear regression model (r(2) = 0.67) also selected RDA as the primary predictor of N(2) fixation. Regression tree models suggest that nutrient controls (phosphorus) were subordinate to physical factors such as depth and RDA. We concluded that regression tree analysis was well suited to revealing nonlinear trends in data (for example, depth), but yielded large uncertainty estimates when applied to linear data (for example, phosphorus). C1 [Forbes, Margaret G.; Doyle, Robert D.; Scott, J. Thad; Stanley, Jacob K.; Brooks, Bryan W.] Baylor Univ, Ctr Reservoir & Aquat Syst Res, Waco, TX 76798 USA. [Forbes, Margaret G.; Doyle, Robert D.; Stanley, Jacob K.; Huang, Hui] Baylor Univ, Dept Biol, Waco, TX 76798 USA. [Scott, J. Thad] Univ Arkansas, Dept Crop Soil & Environm Sci, Fayetteville, AR 72701 USA. [Stanley, Jacob K.] USA, Engineer Res & Dev Ctr, CEERD EP R, Vicksburg, MS 39180 USA. [Brooks, Bryan W.] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA. RP Forbes, MG (reprint author), Baylor Univ, Ctr Reservoir & Aquat Syst Res, 1 Bear Pl 97388, Waco, TX 76798 USA. EM Maggie_Forbes@baylor.edu RI Brooks, Bryan/B-2612-2010; Guenat, Heather/H-6528-2014 OI Brooks, Bryan/0000-0002-6277-9852; FU U. S. Environmental Protection Agency; Texas Commission on Environmental Quality; Brazos River Authority; Baylor University FX This study was supported by grants from the U. S. Environmental Protection Agency through the Texas Commission on Environmental Quality and Brazos River Authority. The authors thank Jason Taylor and Ryan King for discussions regarding CART analysis. Barry Fulton and Theodore Valenti, Jr provided assistance with data collection. Kirk Dean, Shane Prochnow, and Matt Schreiner supported land use analysis. Ken Wagner and Larry Koenig provided useful comments. Additional support was provided for M. G. Forbes through the Baylor University post-doctoral fellowship program. NR 66 TC 14 Z9 16 U1 2 U2 17 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1432-9840 J9 ECOSYSTEMS JI Ecosystems PD NOV PY 2008 VL 11 IS 7 BP 1181 EP 1197 DI 10.1007/s10021-008-9188-2 PG 17 WC Ecology SC Environmental Sciences & Ecology GA 366UX UT WOS:000260510000013 ER PT J AU Le Duc, JW Anderson, K Bloom, ME Estep, JE Feldmann, H Geisbert, JB Geisbert, TW Hensley, L Holbrook, M Jahrling, PB Ksiazek, TG Korch, G Patterson, J Skvorak, JP Weingartl, H AF Le Duc, James W. Anderson, Kevin Bloom, Marshall E. Estep, James E. Feldmann, Heinz Geisbert, Joan B. Geisbert, Thomas W. Hensley, Lisa Holbrook, Michael Jahrling, Peter B. Ksiazek, Thomas G. Korch, George Patterson, Jean Skvorak, John P. Weingartl, Hana TI Framework for Leadership and Training of Biosafety Level 4 Laboratory Workers SO EMERGING INFECTIOUS DISEASES LA English DT Article AB Construction of several new Biosafety Level 4 (BSL-4) laboratories and expansion of existing operations have created an increased international demand for well-trained staff and facility leaders. Directors of most North American BSL-4 laboratories met and agreed upon a framework for leadership and training of biocontainment research and operations staff. They agreed on essential preparation and training that includes theoretical consideration of biocontainment principles, practical hands-on training, and mentored on-the-job experiences relevant to positional responsibilities as essential preparation before a person's independent access to a BSL-4 facility. They also agreed that the BSL-4 laboratory director is the key person most responsible for ensuring that staff members are appropriately prepared for BSL-4 operations. Although standardized certification of training does not formally exist, the directors agreed that facility-specific, time-limited documentation to recognize specific skills and experiences of trained persons is needed. C1 [Le Duc, James W.] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston Natl Lab, Galveston, TX 77555 USA. [Anderson, Kevin; Estep, James E.] Natl Biodef Anal & Countermeasures Ctr, Frederick, MD USA. [Bloom, Marshall E.] Natl Inst Hlth, Hamilton, MT USA. [Feldmann, Heinz] Publ Hlth Agcy Canada, Winnipeg, MB, Canada. [Geisbert, Joan B.; Geisbert, Thomas W.] Boston Univ, Sch Med, Boston, MA 02215 USA. [Hensley, Lisa; Korch, George; Patterson, Jean] USA, Med Res Inst Infect Dis, Frederick, MD USA. [Jahrling, Peter B.] NIH, Bethesda, MD 20892 USA. [Ksiazek, Thomas G.] Ctr Dis Control & Prevent, Atlanta, GA USA. [Patterson, Jean] SW Fdn Biomed Res, San Antonio, TX 78284 USA. [Weingartl, Hana] Canadian Food Inspect Agcy, Winnipeg, MB, Canada. RP Le Duc, JW (reprint author), Univ Texas Med Branch, Inst Human Infect & Immun, Galveston Natl Lab, 301 Univ Blvd, Galveston, TX 77555 USA. EM jwleduc@utmb.edu FU National Institute of Allergy and Infectious Diseases (NIAID) [UC7-AI-070083]; National Institutes of Health; NIAID Division of Intramural Research FX This study was supported by grant UC7-AI-070083 from the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, and by the NIAID Division of Intramural Research. NR 5 TC 10 Z9 10 U1 0 U2 2 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2008 VL 14 IS 11 BP 1685 EP 1688 DI 10.3201/eid1411.080741 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 368JI UT WOS:000260617000001 PM 18976549 ER PT J AU Briese, T Palacios, G Lipkin, WI Renwick, N Venter, M Jarman, RG Dominguez, SR Holmes, KV Holmes, EC AF Briese, Thomas Palacios, Gustavo Lipkin, W. Ian Renwick, Neil Venter, Marietjie Jarman, Richard G. Dominguez, Samuel R. Holmes, Kathryn V. Holmes, Edward C. TI Prior Evidence of Putative Novel Rhinovirus Species, Australia Response SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID GENOTYPE; ILLNESS C1 [Briese, Thomas; Palacios, Gustavo; Lipkin, W. Ian] Columbia Univ, New York, NY USA. [Renwick, Neil] Rockefeller Univ, New York, NY 10021 USA. [Venter, Marietjie] Univ Pretoria, ZA-0002 Pretoria, South Africa. [Jarman, Richard G.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Dominguez, Samuel R.; Holmes, Kathryn V.] Univ Colorado, Denver Sch Med, Aurora, CO USA. [Holmes, Edward C.] Penn State Univ, University Pk, PA 16802 USA. [Holmes, Edward C.] Fogarty Int Ctr, Bethesda, MD USA. RP Briese, T (reprint author), Columbia Univ Epidemiol, Mailman Sch Publ Hlth, Ctr Infect & Immun, 722 W 168th St, New York, NY 10032 USA. EM thomas.briese@columbia.edu RI Venter, Marietjie/H-3032-2011; Venter, Marietjie/P-9604-2016 OI Venter, Marietjie/0000-0003-2696-824X NR 5 TC 0 Z9 0 U1 0 U2 0 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD NOV PY 2008 VL 14 IS 11 BP 1824 EP 1825 DI 10.3201/eid1411.081088 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 368JI UT WOS:000260617000040 ER PT J AU Kim, E Hansen, K Frizzi, J AF Kim, Esther Hansen, Karla Frizzi, James TI Eagle syndrome: Case report and review of the literature SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Review AB Eagle syndrome, which is an uncommon sequela of elongation of the styloid process, can manifest as pain in the anterolateral neck, often with referred pain to the ear. In most cases, the elongation is an acquired condition, often occurring as a result of a traumatic incident, including tonsillectomy. We describe the case of a 57-year-old man who experienced unremitting right neck pain for several years following an accidental fall. A multidisciplinary investigation identified an elongated styloid process. Surgical shortening of the structure provided definitive relief of the patient's symptoms. We review the anatomy of the peristylold structures and discuss the etiology, diagnosis, and treatment of Eagle syndrome. C1 [Hansen, Karla] Dwight D Eisenhower Army Med Ctr, MCHF SD, Dept Otolaryngol Head & Neck Surg, Ft Gordon, GA 30905 USA. [Kim, Esther; Frizzi, James] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. RP Hansen, K (reprint author), Dwight D Eisenhower Army Med Ctr, MCHF SD, Dept Otolaryngol Head & Neck Surg, Ft Gordon, GA 30905 USA. EM karla.k.hansen@us.army.mil NR 12 TC 16 Z9 16 U1 0 U2 0 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD NOV PY 2008 VL 87 IS 11 BP 631 EP 633 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA V10PE UT WOS:000207475100008 PM 19006064 ER PT J AU Smith, KW Proctor, SP McClean, MD AF Smith, K. W. Proctor, S. P. McClean, M. D. TI Repeated Measures of Inhalation and Dermal Exposure to Jet Fuel Among Air Force Personnel SO EPIDEMIOLOGY LA English DT Meeting Abstract CT 20th Annual Conference of the International-Society-for-Environmental-Epidemiology CY OCT 12-16, 2008 CL Pasadena, CA SP Int Soc Environm Epidemiol C1 [Smith, K. W.; McClean, M. D.] Boston Univ, Sch Publ Hlth, Boston, MA USA. [Proctor, S. P.] USA, Environm Med Res Inst, Natick, MA 01760 USA. RI McClean, Michael/J-2934-2015 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1044-3983 J9 EPIDEMIOLOGY JI Epidemiology PD NOV PY 2008 VL 19 IS 6 BP S179 EP S179 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 362IR UT WOS:000260191900509 ER PT J AU Patel, OV Zakrzewska, E Maple, RL Baer, LA Ronca, AE Wade, CE Plaut, K AF Patel, Osman V. Zakrzewska, Elzbieta Maple, Rhonda L. Baer, Lisa A. Ronca, April E. Wade, Charles E. Plaut, Karen TI Lipogenesis impaired in periparturient rats exposed to altered gravity is independent of prolactin and glucocorticoid secretion SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE gravity; glucocorticoid; lactating; lipogenesis; prolactin; rats; receptor ID RECEPTOR GENE-EXPRESSION; LACTATING MAMMARY-GLAND; LIPID-METABOLISM; ADIPOSE-TISSUE; FOOD-INTAKE; CELL-SIZE; SIGNAL-TRANSDUCTION; HORMONAL-REGULATION; TRANSGENIC MICE; KNOCKOUT MICE AB Perturbed prolactin (PRL) secretion and concomitant downregulation of PRL receptor (PRLR) in periparturient dams exposed to altered gravity are linked to aberrant lipogenesis and reduced neonatal survival. PRL and glucocorticoids (GC) are known to modulate PRLR expression. We hypothesized that improving levels of PRLR would mitigate the increased gravity [hypergravity (HG)]-induced effects of impaired mammary lipogenesis and increase neonatal survival. The objective of this study was to determine if prepartum PRL or GC supplementation would override the HG-induced repression of PRLR along with lipogenic genes and increase tissue fatty acid synthesis. Pregnant rats were exposed to either 2g (HG) or kept at 1g (control) from day 11 of gestation (G11) through Postnatal day 1 (P1). HG exposed rats were supplemented with either PRL or corticosterone or a placebo from G13 to P1. On P1, mammary, liver and adipose tissues were collected to measure glucose incorporation into lipids and mRNA abundance of PRL long and short form receptors (Prlr-l, Prlr-s), glucocorticoid receptor (Nr3c1), Acetyl CoA carboxylase-alpha (Acaca), fatty acid synthase (Fasn), lipoprotein lipase (Lpl), Sterol Regulatory Element Binding Protein-1 (Srebp1) and protein kinase B (Akt1) genes by quantitative polymerase chain reaction (qPCR). PRL and GC supplementation had a limited effect on lipogenesis in the three tissues of HG group likely due to their inability to increase abundance of key down-regulated genes, including Prlr-l and Nr3c1. There was no difference in the abundance of genes coding for milk proteins or those associated with milk fat globule formation and secretion. These data suggest that reduced lipogenesis in HG exposed dams is independent of PRL and GC secretion but may be associated with dysregulation of multiple metabolic regulators at the level of mRNA expression. C1 [Patel, Osman V.; Plaut, Karen] Michigan State Univ, Dept Anim Sci, E Lansing, MI 48824 USA. [Zakrzewska, Elzbieta; Maple, Rhonda L.] Univ Vermont, Burlington, VT 05405 USA. [Baer, Lisa A.; Wade, Charles E.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Ronca, April E.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC 27157 USA. RP Patel, OV (reprint author), Michigan State Univ, Dept Anim Sci, B290 Anthony Hall, E Lansing, MI 48824 USA. EM patelo@msu.edu FU NASA [NNA05CP91A, NNA04CK83] FX We extend our gratitude to the staff of NASA Ames Research Center Acceleration facility for their expert help with running of the experiment, and Jim Liesman for his help with statistical analysis. This work was supported by NASA grants NNA05CP91A and NNA04CK83. NR 55 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD NOV PY 2008 VL 104 IS 5 BP 847 EP 858 DI 10.1007/s00421-008-0840-5 PG 12 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 357QQ UT WOS:000259861600011 PM 18665386 ER PT J AU Seehusen, DA AF Seehusen, Dean A. TI Going Home SO FAMILY MEDICINE LA English DT Editorial Material C1 [Seehusen, Dean A.] Einsenhower Army Med Ctr, Dept Family & Community Med, Ft Gordon, GA USA. RP Seehusen, DA (reprint author), 212 Bainbridge Dr, Evans, GA 30809 USA. EM dseehusen@msn.com NR 0 TC 1 Z9 1 U1 0 U2 0 PU SOC TEACHERS FAMILY MEDICINE PI LEAWOOD PA 11400 TOMAHAWK CREEK PARKWAY, STE 540, LEAWOOD, KS 66207 USA SN 0742-3225 J9 FAM MED JI Fam. Med. PD NOV-DEC PY 2008 VL 40 IS 10 BP 700 EP 701 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 373RA UT WOS:000260988500007 PM 19039860 ER PT J AU Browne, H McCarthy-Keith, D Stegmann, B Spies, J Armstrong, A AF Browne, Hyacinth McCarthy-Keith, Desiree Stegmann, Barbara Spies, James Armstrong, Alicia TI Ovarian response in women undergoing ovarian stimulation after myomectomy SO FERTILITY AND STERILITY LA English DT Editorial Material DE Fibroids; myomectomy; ovarian reserve; assisted reproductive technology ID UTERINE ARTERY EMBOLIZATION; IN-VITRO FERTILIZATION; RESERVE; LEIOMYOMATA; HYSTERECTOMY AB Objective: To examine ovarian response in infertile women undergoing ovarian stimulation after abdominal myomectomy. Design: Case report. Setting: Academic medical research center. Patient(s): Four infertile women with known fibroids who had a failed assisted reproductive technology (ART) cycle followed by an abdominal myomectomy. Intervention(s): Infertile women with known fibroids who had a failed ART cycle, from January 2000 to December 2006, followed by an abdominal myomectomy and a subsequent ART cycle. Main Outcome Measure(s): Ovarian function before (baseline) and after myomectomy was assessed by age, day 3 and day 10 FSH levels, days of stimulation, total gonadotropins used, peak E(2) level, the number of oocytes retrieved and embryos obtained, the number of high-grade embryos, and pregnancy outcome. Result(s): The mean age was 35 and 36 years before and after myomectomy, respectively. All subjects had uterine factor infertility. Two of these women also had tubal factor infertility, and one had endometriosis and male factor infertility. There was no difference in ovarian response before and after myomectomy. Conclusion(s): As expected, abdominal myomectomy did not adversely affect ovarian response in infertile women undergoing ovarian stimulation after a failed ART cycle. Larger randomized prospective studies are needed to accurately assess whether myomectomy has a negative impact on ovarian response. (Fertil Steril (R) 2008; 90: 2004. e19-e21. (C)2008 by American Society for Reproductive Medicine.) C1 [Browne, Hyacinth; McCarthy-Keith, Desiree; Stegmann, Barbara; Armstrong, Alicia] NICHHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA. [Browne, Hyacinth; McCarthy-Keith, Desiree; Stegmann, Barbara; Armstrong, Alicia] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Spies, James] Georgetown Univ Hosp, Dept Radiol, Intervent Radiol Sect, Washington, DC 20007 USA. RP Browne, H (reprint author), NICHD, Program Reprod & Adult Endocrinol, NIH, CRC 1 E Rm 1-E-3140,10 Ctr Dr, Bethesda, MD 20892 USA. EM brownehy@mail.nih.gov FU National Institute of Child Health and Human Development, National Institutes of Health FX Carried out under Walter Reed Army Medical Center Department of Clinical Investigations protocol WU #08-04-44018hEX(1) and supported in part by the Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health. NR 14 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD NOV PY 2008 VL 90 IS 5 AR 2004.e19 DI 10.1016/j.fertnstert.2008.04.008 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA V13XQ UT WOS:000207699900010 PM 18565518 ER PT J AU Chason, RJ Levens, ED Yauger, BJ Payson, MD Cho, K Larsen, FW AF Chason, Rebecca J. Levens, Eric D. Yauger, Belinda J. Payson, Mark D. Cho, Kenneth Larsen, Frederick W. TI Balloon fluoroscopy as treatment for intrauterine adhesions: a novel approach SO FERTILITY AND STERILITY LA English DT Editorial Material DE Asherman's syndrome; synechiae; intrauterine adhesions; balloon dilation; cesarean section scar ID CESAREAN-SECTION SCAR; SONOHYSTEROGRAPHY AB Objective: To report a unique fluoroscopically guided approach to treat severe intrauterine adhesions and cervical stenosis using balloon hysteroplasty. Design: Case report. Setting: Military-based fertility center. Patient(s): A 33-year-old woman undergoing assisted reproductive technology whose uterus could not be cannulated because of the development of intrauterine synechiae and cervical stenosis after a post-IUI infection that was further complicated by a prominent lower uterine segment-filling defect in the location of a prior cesarean delivery scar. Intervention(s): Fluoroscopic cannulation and balloon uterine dilation. Main Outcome Measure(s): Resolution of synechiae by hysterosalpingogram and successful uterine cannulation. Result(s): A postprocedure hysterosalpingogram demonstrated a normalized uterine cavity with the exception of a persistent prominent lower uterine segment-filling defect from a prior cesarean delivery. A frozen ET cycle was performed successfully. Conclusion(s): Hysteroplasty, using standard interventional radiographic techniques, may provide an alternative treatment modality for patients with intrauterine adhesions and lower uterine defects from prior cesarean deliveries in select cases. While treating intrauterine adhesions improves pregnancy outcome, the effect of lower uterine segment-filling defects from cesarean deliveries on pregnancy outcome in assisted reproductive technology cycles warrants further investigation. (Fertil Steril (R) 2008; 90: 2005. e15-e17. (C)2008 by American Society for Reproductive Medicine.) C1 [Chason, Rebecca J.] NICHHD, Natl Naval Med Ctr, NIH, Bethesda, MD 20892 USA. [Levens, Eric D.; Yauger, Belinda J.] NICHHD, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA. [Yauger, Belinda J.; Payson, Mark D.; Cho, Kenneth; Larsen, Frederick W.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Chason, RJ (reprint author), Care of Cyoyle MP, Natl Naval Med Ctr, Bldg 1,Rm 2435,8901 Rockville Pike, Bethesda, MD 20889 USA. EM rebecca.chason@amedd.army.mil FU Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institutes of Health, Bethesda, Maryland FX This research was supported, in part, by the Program in Reproductive and Adult Endocrinology of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institutes of Health, Bethesda, Maryland. NR 11 TC 2 Z9 2 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD NOV PY 2008 VL 90 IS 5 AR 2005.e15 DI 10.1016/j.fertnstert.2008.07.1752 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA V13XQ UT WOS:000207699900016 PM 18793771 ER PT J AU Carlson, JW Stojadinovic, A Ennis, W Diegelmann, R Attinger, C AF Carlson, Jay W. Stojadinovic, Alexander Ennis, William Diegelmann, Robert Attinger, Christopher TI Multidisciplinary panel discussion of a gynecologic oncology patient: Preventing wound complications SO GYNECOLOGIC ONCOLOGY LA English DT Article DE Gynecologic oncology; Wound infection; Perioperative morbidity; Complex wound ID PROPHYLAXIS; INFECTION AB At the 39th meeting of the Society of Gynecologic Oncologists, a multidisciplinary panel presented and discussed the current management strategies for the treatment of complex wounds. After the presentations, the panel discussed the management options for a morbidly obese endometrial cancer patient with a focus toward the complex wound that may delay discharge, healing, or the start of adjuvant treatment. This article highlights the clinical considerations discussed for these types of patients. (C) 2008 Elsevier Inc. All rights reserved. C1 [Carlson, Jay W.] Gynecol Oncol W Michigan, Grand Rapids, MI USA. [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Div Surg Oncol, Washington, DC 20307 USA. [Ennis, William] Univ Illinois, Div Wound Care & Tissue Repair, Chicago, IL USA. [Diegelmann, Robert] Virginia Commonwealth Univ, Lab Tissue Repair, Richmond, VA USA. [Attinger, Christopher] Georgetown Univ, Wound Healing Ctr, Washington, DC USA. RP Carlson, JW (reprint author), Gynecol Oncol W Michigan, Grand Rapids, MI USA. EM jaycarlson1@mac.com NR 10 TC 2 Z9 2 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2008 VL 111 IS 2 SU 1 BP S98 EP S100 DI 10.1016/j.ygyno.2008.08.010 PG 3 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 375BL UT WOS:000261087800018 PM 18786719 ER PT J AU Stojadinovic, A Carlson, JW Schultz, GS Davis, TA Elster, EA AF Stojadinovic, Alexander Carlson, Jay W. Schultz, Gregory S. Davis, Thomas A. Elster, Eric A. TI Topical advances in wound care SO GYNECOLOGIC ONCOLOGY LA English DT Review DE Wound healing; Chronic wound; Wound bed preparation ID ACELLULAR DERMAL MATRIX; GROWTH-FACTOR-BB; GASTROINTESTINAL CANCER-PATIENTS; COMPROMISED SURGICAL FIELD; TOTAL PARENTERAL-NUTRITION; EXTREMITY DIABETIC ULCERS; ABDOMINAL-WALL DEFECTS; VENTRAL HERNIA REPAIR; BREAST RECONSTRUCTION; BURN WOUNDS AB There are fundamental differences between acute wounds that proceed to uncomplicated healing and those that become chronic wounds. Non-healing or chronic wounds can result from a combination of overlapping factors that prevent healing, including local tissue ischemia, repetitive trauma and ischemia/reperfusion injury presence of tissue necrosis, impaired cellular and systemic host response to stress, and critical bacterial contamination. The bacterial burden in the wound contributes to a sustained inflammatory state, which inhibits normal progression to the proliferative phase of healing, thereby preventing restoration of tissue integrity. Appropriate wound bed preparation removes local barriers to healing and optimizes the tissue environment to achieve wound healing. It is an essential element of wound management that advances endogenous healing as well as the efficacy of topical and other wound therapy. This article will summarize a systematic approach to wound bed preparation using the "TIME" principle, and will highlight important advances in topical wound care. Published by Elsevier Inc. C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. [Davis, Thomas A.; Elster, Eric A.] USN, Med Res Ctr, Silver Spring, MD USA. [Stojadinovic, Alexander; Davis, Thomas A.; Elster, Eric A.] Combat Wound Initiat, Washington, DC USA. [Carlson, Jay W.] Gynecol Oncol W Michigan, Grand Rapids, MI USA. [Schultz, Gregory S.] Univ Florida, Dept Obstet & Gynecol, Gainesville, FL 32611 USA. [Davis, Thomas A.; Elster, Eric A.] Natl Naval Med Ctr, Dept Surg, Bethesda, MD USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. EM alexander.stojadinovic@amedd.army.mil NR 101 TC 32 Z9 33 U1 7 U2 14 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 2008 VL 111 IS 2 SU 1 BP S70 EP S80 DI 10.1016/j.ygyno.2008.07.042 PG 11 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 375BL UT WOS:000261087800014 PM 18793796 ER PT J AU McPherson, NA Neal, TA Johnson, TE AF McPherson, Nicole A. Neal, Thomas A. Johnson, Thomas E. TI The Potential Hidden Hazards of a Laser Pumped Tunable OPO System SO HEALTH PHYSICS LA English DT Article DE operational topics; lasers; exposure; radiofrequency; radiation protection ID OPTICAL FREQUENCIES; OSCILLATION AB Laser pumped tunable optical parametric oscillator (OPO) systems from 1,300 to 2,200 nm have been introduced due to their retina-safe characteristics and ability to adjust to multiple wavelengths. We report on unintended consequences to a rabbit cornea resulting from OPO exposure. No gross injury was visible to the cornea post exposure,however, closer examination revealed a vitreous hemorrhage had occurred within the eye. Evaluation of the tunable laser system revealed a cracked crystal and a resultant 1,064 nm emission from the pump laser, rather than the desired 1,540 urn wavelength. This incident illustrates the importance of protective eyewear shielding against all potential wavelengths, including the pump lasers, when operating OPO tunable laser systems. Health Phys. 95(Supplement 5):S194-S196; 2008 C1 [McPherson, Nicole A.] Tripler Army Med Ctr, Directorate Hlth Educ & Training, Honolulu, HI 96859 USA. [Neal, Thomas A.] MITRE Corp, Ctr Enteiprise Modernizat, Mclean, VA 22102 USA. [Johnson, Thomas E.] Colorado State Univ, Ft Collins, CO 80523 USA. RP McPherson, NA (reprint author), Tripler Army Med Ctr, Directorate Hlth Educ & Training, Honolulu, HI 96859 USA. EM nicole.mcpherson@us.amy.mil FU DoD [DAMD17-03-0032]; CDMRP; PRMRP; U.S. Army Medical Research and Material Command Fort Detrick, MD FX This incident occurred during a project funded under grant DAMD17-03-0032 from the DoD, CDMRP, PRMRP, U.S. Army Medical Research and Material Command Fort Detrick, MD. The funded project was to assess the Corneal effects for pulsed laser exposure at 1,540 nm.; The views, opinions, and/or findings contained in this report are those or the authors and do not necessarily reflect those of the Uniformed Services University of Health Science (USUHS), the Department of Defense or Colorado State University. The authors would like to thank Golda Winston, Laticia Sanders, Tridaugh Winston, Don Randolph, and Aimee Oke for their outstanding support and assistance. NR 8 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD NOV PY 2008 VL 95 IS 5 SU S BP S194 EP S196 DI 10.1097/01.HP.0000326330.24845.8b PG 3 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA 363UU UT WOS:000260293200009 PM 18849714 ER PT J AU Scheithauer, BW Santi, M Richter, ER Belman, B Rushing, EJ AF Scheithauer, Bernd W. Santi, Mariarita Richter, Eric R. Belman, Barry Rushing, Elisabeth J. TI Diffuse ganglioneuromatosis and plexiform neurofibroma of the urinary bladder: report of a pediatric example and literature review SO HUMAN PATHOLOGY LA English DT Article DE Urinary bladder; Ganglioneuromatosis; Plexiform neurofibroma; Neurofibromatosis type 1; Immunohistochemistry ID VONRECKLINGHAUSEN NEUROFIBROMATOSIS; CHILDREN; TRACT AB As an initial manifestation of neurofibromatosis type 1, isolated neurofibroma of the urinary bladder occurs only rarely in the first 2 decades of life. We report a case of a 6-year-old African-American girl who presented in this manner and was found to have a plexiform neurofibroma as well as diffuse ganglioneuromatosis of the urinary bladder. We describe the clinical presentation, diagnostic procedures, and pathologic features encountered. In addition, we review the literature with respect to etiology, current treatment strategies, and the issue of surveillance for this complex lesion occurring in the pediatric population. Neurofibroma of the bladder should be considered in the differential diagnosis of painless hematuria in childhood. Its presentation in such patients warrants a complete evaluation to establish the diagnosis of neurofibromatosis type 1 and begin long-term surveillance for its associated manifestations. At present, there are no established criteria for the treatment of this rare lesion. (C) 2008 Published by Elsevier Inc. C1 [Scheithauer, Bernd W.] Mayo Clin, Dept Pathol & Lab Med, Rochester, MN 55905 USA. [Santi, Mariarita] Childrens Natl Med Ctr, Div Pathol, Washington, DC 20010 USA. [Belman, Barry] Childrens Natl Med Ctr, Div Urol, Washington, DC 20010 USA. [Richter, Eric R.] Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. [Rushing, Elisabeth J.] Armed Forces Inst Pathol, Dept Neuropathol & Ophthalm Pathol, Washington, DC 20306 USA. RP Scheithauer, BW (reprint author), Mayo Clin, Dept Pathol & Lab Med, Rochester, MN 55905 USA. EM scheithauer.bernd@mayo.edu NR 15 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD NOV PY 2008 VL 39 IS 11 BP 1708 EP 1712 DI 10.1016/j.humpath.2008.02.019 PG 5 WC Pathology SC Pathology GA 366BP UT WOS:000260455300019 PM 18656232 ER PT J AU Kant, L Young, K Younis, O Shallcross, D Sinkar, K McAuley, A Manousakis, K Chang, K Graff, C AF Kant, Latha Young, Kenneth Younis, O. Shallcross, D. Sinkar, K. McAuley, A. Manousakis, K. Chang, K. Graff, Charles TI Network Science Based Approaches to Design and Analyze MANETs for Military Applications SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Mobile ad hoc networks have become the basis of the military's network-centric warfare (NCW) approach. However, for NCW to be successful, it is imperative that the networks be designed in a robust manner with the capability to produce consistent predictable results despite the uncertainties of the underlying environment. This underscores the need for formal systematic methodologies to design and predict performance of such networks. The challenges of mobile ad hoc networking combined with those associated with the stringent requirements posed by NCW systems, however, are daunting, and thus no systematic design techniques for NCW system design exist. To address this problem, a joint project was initiated between CERDEC and Telcordia Technologies to develop the Network Engineering Design Analytic Toolset (NEDAT) - a toolset that applies network-science-based approaches to design MANETs for use in NCW. Rooted in formal/analytic techniques, NEDAT can be used to design MANETs for use in NCW given information about available resources and performance objectives, analyze performance of a given NCW network, and understand design trades. C1 [Kant, Latha] Telcordia Technol, Appl Res, Mobile Networking Res Dept, Red Bank, NJ USA. [Young, Kenneth] Telcordia Technol, Govt Project Dev Appl Res Org, Red Bank, NJ USA. [Graff, Charles] USA, CERDEC, RDECOM Ft Monmouth, Ft Monmouth, NJ USA. [Shallcross, D.] Telcordia Technol, Appl Res, Informat Anal & Serv Dept, Red Bank, NJ USA. [Sinkar, K.; Manousakis, K.] Telcordia Technol, Appl Res, Mobil Management Res Dept, Red Bank, NJ USA. [Chang, K.] Telcordia Technol, Appl Res Area, Red Bank, NJ USA. RP Kant, L (reprint author), Telcordia Technol, Appl Res, Mobile Networking Res Dept, Red Bank, NJ USA. EM lkant@telcordia.com FU CERDEC STCD Network Design Program FX The Telcordia Team acknowledges with gratitude the support from CERDEC STCD Network Design Program for funding this work. Our thanks also go to Dr. Graff and his team members, William Kline, David Yee, and Liweih Wright, for their help implementing portions of the NEDAT prototype. NR 9 TC 8 Z9 8 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0163-6804 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD NOV PY 2008 VL 46 IS 11 BP 55 EP 61 DI 10.1109/MCOM.2008.4689245 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 371YB UT WOS:000260867500007 ER PT J AU Koop, CE Mosher, R Kun, L Geiling, J Grigg, E Long, S Macedonia, C Merrell, RC Satava, R Rosen, JM AF Koop, C. Everett Mosher, Robyn Kun, Luis Geiling, Jim Grigg, Eliot Long, Sarah Macedonia, Christian Merrell, Ronald C. Satava, Richard Rosen, Joseph M. TI Future Delivery of Health Care: Cybercare A Distributed Network-Based Health-Care System SO IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE LA English DT Article ID TELEMEDICINE; INFORMATION C1 [Mosher, Robyn; Rosen, Joseph M.] Dartmouth Hitchcock Med Ctr, Dartmouths Thayer Sch Engn, Lebanon, NH 03756 USA. [Koop, C. Everett] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA. [Kun, Luis] NDU, IRM Coll, Washington, DC USA. [Geiling, Jim] Vet Affairs Med Ctr, ICU, Dortmouth Hithcock Med Ctr, White River Jct, VT USA. [Merrell, Ronald C.] Virginia Commonwealth Univ, Dept Surg, Richmond, VA 23284 USA. [Merrell, Ronald C.] Virginia Commonwealth Univ, Hlth Syst Telemed Program, Richmond, VA 23284 USA. [Satava, Richard] Univ Washington, Med Ctr, Seattle, WA 98195 USA. [Satava, Richard] USA, Med Res & Mat Command, Ft Detrick, MD USA. RP Rosen, JM (reprint author), Dartmouth Hitchcock Med Ctr, Dartmouths Thayer Sch Engn, 1 Med Ctr Dr, Lebanon, NH 03756 USA. EM Rosen@Dartmouth.edu NR 35 TC 20 Z9 20 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0739-5175 J9 IEEE ENG MED BIOL JI IEEE Eng. Med. Biol. Mag. PD NOV-DEC PY 2008 VL 27 IS 6 BP 29 EP 38 DI 10.1109/MEMB.2008.929888 PG 10 WC Engineering, Biomedical; Medical Informatics SC Engineering; Medical Informatics GA 374XN UT WOS:000261077100007 PM 19004693 ER PT J AU Bai, H Mi, CC Gargies, S AF Bai, Hua Mi, Chunting Chris Gargies, Sonya TI The Short-Time-Scale Transient Processes in High-Voltage and High-Power Isolated Bidirectional DC-DC Converters SO IEEE TRANSACTIONS ON POWER ELECTRONICS LA English DT Article DE DC-DC converter; deadband effect; high-frequency transformer; phase shift; short-time-scale; transient process ID PHASE-SHIFT CONTROL; COMPENSATION; SYSTEM AB This paper discusses the short-time-scale transient processes in an isolated bidirectional dc-dc converter with phase-shift control. The deadband effect on the steady-state and transient commutating process are analyzed. The current variations caused by phase-shift errors at the boundary conditions are simulated and validated through experiments. The concept of "energy deadband" is introduced to describe those specific transients where no energy flows from source to load or load to source. A set of strategies are proposed to increase the system robustness. Simulation and experiments on a 200-V/400-V, 6-kW dc-dc converter prototype validated these strategies. C1 [Bai, Hua; Mi, Chunting Chris] Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. [Gargies, Sonya] USA, Res Dev & Engn Command RDECOM, Tank Automot & Armament Res Dev & Engn Command, Ground Vehicle Power & Mobil, Warren, MI 48397 USA. RP Bai, H (reprint author), Univ Michigan, Dept Elect & Comp Engn, Dearborn, MI 48128 USA. EM chrismi@umich.edu; sonya.gargies@us.army.mil RI Mi, Chunting/E-3769-2013 OI Mi, Chunting/0000-0002-5471-8953 FU U.S. Army Tank Automotive and Armament Research, Development, and Engineering Command (TARDEC) FX This work was supported by the U.S. Army Tank Automotive and Armament Research, Development, and Engineering Command (TARDEC). Recommended for publication by Associate Editor A. Rufer. NR 23 TC 36 Z9 42 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0885-8993 J9 IEEE T POWER ELECTR JI IEEE Trans. Power Electron. PD NOV PY 2008 VL 23 IS 6 BP 2648 EP 2656 DI 10.1109/TPEL.2008.2005106 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA 390HB UT WOS:000262153800002 ER PT J AU Coovert, MD Walvoord, AA Elliott, LR Redden, ES AF Coovert, Michael D. Walvoord, Ashley A. Elliott, Linda R. Redden, Elizabeth S. TI A Tool for the Accumulation and Evaluation of Multimodal Research SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART C-APPLICATIONS AND REVIEWS LA English DT Editorial Material DE Auditory systems; cognitive science; human factors; multimodal interfaces; tactile system; user interfaces; visual systems ID PERFORMANCE; FEEDBACK; ROBOT AB A surge of interest exists in multimodal research and interfaces. This is due, at least in part, to an exponential increase in the amount and type of information that can be presented to a user. When a great deal of information is presented via a single sensory modality, it can exceed the operator's capacity to manage the information efficiently, generating cognitive overload. As a consequence, the user's performance becomes susceptible to slower response times, loss of situational awareness, faulty decision making, and execution errors. Researchers and designers have responded to these issues with the development and application of multiniodal information displays. The cross-disciplinary flavor of multimodal applications presents a challenge to the accumulation, evaluation, and dissemination of relevant research. We describe the development of a taxonomy for the evaluation and comparison of multimodal display research studies, and the implementation of the taxonomy into a database: the Multimodal Query System (MQueS). C1 [Coovert, Michael D.; Walvoord, Ashley A.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Coovert, Michael D.] Univ S Florida, Inst Human Performance Decis Making & Cybernet, Tampa, FL 33620 USA. [Coovert, Michael D.] MDC & Associates Inc, Plant City, FL 33620 USA. [Elliott, Linda R.; Redden, Elizabeth S.] USA, Res Lab, Human Res & Engn Directorate, Ft Benning, GA 31905 USA. RP Coovert, MD (reprint author), Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. EM coovert@luna.cas.usf.edu; ashleywalvoord@gmail.com; linda.r.elliott@us.army.mil; elizabeth.s.redden@us.army.mil NR 28 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1094-6977 J9 IEEE T SYST MAN CY C JI IEEE Trans. Syst. Man Cybern. Part C-Appl. Rev. PD NOV PY 2008 VL 38 IS 6 BP 850 EP 855 DI 10.1109/TSMCC.2008.2001695 PG 6 WC Computer Science, Artificial Intelligence; Computer Science, Cybernetics; Computer Science, Interdisciplinary Applications SC Computer Science GA 372KA UT WOS:000260899300013 ER PT J AU Chakka, V Trabia, MB O'Toole, B Sridharala, S Ladkany, S Chowdhury, M AF Chakka, Vinod Trabia, Mohamed B. O'Toole, Brendan Sridharala, Srujanbabu Ladkany, Samaan Chowdhury, Mostafiz TI Modeling and reduction of shocks on electronic components within a projectile SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE projectile; modeling; shock; finite element; electronic components AB Electronic components within a projectile are subjected to severe loads over an extremely short duration during the launch process. Failure of these components during launch can result in negative effects on the mission of the projectile. While experimental data can be helpful in understanding failure of electronic components within a projectile, collecting such data are usually difficult. There are also limitations oil the reliability of sensors under these circumstances. Finite element modeling (FEM) can offer a means to better understand the behavior of these components. It can also be used to develop better shock mitigation features into the projectile design. This research has two objectives. The first objective is to develop an FEM that one describes the interaction of a typical projectile with the gun barrel during launch. The projectile includes a payload of a one-pound mass representing a typical electronic package supported by a plate. The second objective of this work is to investigate the use of composite plates to support electronic payload as a means to reduce the transmitted shocks during the projectile launch event. The proposed plate has carbon fibers embedded in an epoxy matrix. A parametric study of the effects of varying the thickness of the supporting plate and the fiber volume fraction on the accelerations and stresses is included. Results of the study are used to reach general recommendations regarding reducing failure of electronic components within a projectile. (C) 2007 Elsevier Ltd. All rights reserved. C1 [Chakka, Vinod; Trabia, Mohamed B.; O'Toole, Brendan; Sridharala, Srujanbabu] Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA. [Ladkany, Samaan] Univ Nevada, Dept Civil & Environm Engn, Las Vegas, NV 89154 USA. [Chowdhury, Mostafiz] USA, AMSRL WM MB ALC, Ordnance Mat Branch, Weapons & Mat Res Directorate,Res Lab, Adelphi, MD 20783 USA. RP Trabia, MB (reprint author), Univ Nevada, Dept Mech Engn, Las Vegas, NV 89154 USA. EM vinod_engg1@yahoo.com; mbt@me.unlv.edu; bj@me.unlv.edu; srujanbabus@yahoo.com; samaan@ce.unlv.edu; MChowdhury@arl.army.mil OI Trabia, Mohamed/0000-0003-3090-9672 FU ARL through the Soldier's Future Force Electronics Reliability and Survivability Technology Program (Soldier FERST) [DAAD 19-03-2-0007] FX The authors would like to acknowledge the help of Dr. Donald Carlucci, Mr. Matt Hawkswell, and Mr. Michael Hollis (US Army TACOM-ARDEC) for their continued support and numerous discussions. The authors would also like to thank Mr. Ami Frydman, US Army Research Laboratory, for suggesting this research topic and interacting with the authors. Funding for the work is provided by ARL through the Soldier's Future Force Electronics Reliability and Survivability Technology Program (Soldier FERST), cooperative agreement number DAAD 19-03-2-0007. NR 17 TC 7 Z9 8 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD NOV PY 2008 VL 35 IS 11 BP 1326 EP 1338 DI 10.1016/j.ijimpeng.2007.07.005 PG 13 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 346OI UT WOS:000259077700011 ER PT J AU Johnston, J Johnston, EA AF Johnston, Jarold (Tom) Johnston, Elizabeth A. TI On Bed Sharing SO JOGNN-JOURNAL OF OBSTETRIC GYNECOLOGIC AND NEONATAL NURSING LA English DT Letter C1 [Johnston, Jarold (Tom)] Ft Drum Obstet & Gynecol, Watertown, NY 13601 USA. [Johnston, Jarold (Tom)] USA, Watertown, NY USA. [Johnston, Jarold (Tom)] Samaritan Med Ctr, Watertown, NY USA. [Johnston, Elizabeth A.] RNC, Watertown, NY USA. RP Johnston, J (reprint author), Ft Drum Obstet & Gynecol, 826 Washington St,Suite 202, Watertown, NY 13601 USA. EM jarold.johnston@us.army.mil NR 6 TC 3 Z9 3 U1 0 U2 2 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0884-2175 J9 JOGNN-J OBST GYN NEO JI JOGNN PD NOV-DEC PY 2008 VL 37 IS 6 BP 619 EP 621 DI 10.1111/j.1552-6909.2008.00287.x PG 3 WC Nursing; Obstetrics & Gynecology SC Nursing; Obstetrics & Gynecology GA 370CK UT WOS:000260740100002 PM 19012710 ER PT J AU Chahine, G Koike, M Okabe, T Smith, P Kovacevic, R AF Chahine, Gilbert Koike, Mari Okabe, Toru Smith, Pauline Kovacevic, Radovan TI The design and production of Ti-6Al-4V ELI customized dental implants SO JOM LA English DT Article AB This paper addresses the production of customized Ti-6Al-4V ELI dental implants via electron beam melting (EBM). The melting of Ti-6Al-4V ELI powder produces implants with great biocompatibility, fi ne mechanical performance, and a high bone ingrowth potential. The EBM technology is used to produce one-component dental implants that mimic the exact shape of the patient's tooth, replacing the traditional, three-component, "screw-like" standardized dental implants currently used. The new generation of implants provides the possibility of simplifying pre-insertion procedures leading to faster healing time, and the potential of better and stronger osseointegration, specifi cally through incorporating lattice structure design. C1 [Chahine, Gilbert; Kovacevic, Radovan] So Methodist Univ, Res Ctr Adv Mfg, Dept Mech Engn, Dallas, TX 75205 USA. [Koike, Mari] Baylor Coll Dent, Texas A&M Hlth Sci Ctr, Dept Biomat Sci, Dallas, TX 75246 USA. [Smith, Pauline] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Chahine, G (reprint author), So Methodist Univ, Res Ctr Adv Mfg, Dept Mech Engn, Dallas, TX 75205 USA. EM gchahine@smu.edu FU U. S. Army Research Office provided Southern Methodist University (SMU) [W911NF-07-2-0056] FX The U. S. Army Research Office provided Southern Methodist University (SMU) a grant to develop a program titled "Advanced Precision Supply Parts Manufacturing," Grant No. W911NF-07-2-0056. In October 2007, in cooperation with the Army Research Laboratory, SMU acquired the ARCAM A2 machine for solid freeform fabrication by electron beam in a vacuum environment manufactured by ARCAM AB Gothenburg, Sweden. NR 12 TC 24 Z9 24 U1 0 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1047-4838 J9 JOM-US JI JOM PD NOV PY 2008 VL 60 IS 11 BP 50 EP 55 DI 10.1007/s11837-008-0148-2 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA 372BX UT WOS:000260877500008 ER PT J AU Fitzgibbon, JE Sagripanti, JL AF Fitzgibbon, J. E. Sagripanti, J. -L. TI Analysis of the survival of Venezuelan equine encephalomyelitis virus and possible viral simulants in liquid suspensions SO JOURNAL OF APPLIED MICROBIOLOGY LA English DT Article DE alphavirus; biodefense; disinfection; environmental water; Sindbis; simulant; Venezuelan equine encephalitis; water ID PLASMA-DERIVED PRODUCTS; FELINE CALICIVIRUS; ESCHERICHIA-COLI; SOLAR-RADIATION; SINDBIS-VIRUS; PLAQUE-ASSAY; INACTIVATION; MS2; COLIPHAGE; TEMPERATURE AB Aims: To compare the inactivation rate of Venezuelan equine encephalomyelitis (VEE) virus in liquids to that of Sindbis virus (SV, another alphavirus) and to a bacteriophage (MS2) generally used as a viral simulant in the development of countermeasures in biodefense. Methods and Results: Viruses were inoculated into liquids and viral titres were determined at various times postinoculation. The viruses were stable in distilled-deionized (dd) water at 4 degrees C during the 21 days of the study. The inactivation rates of VEE and SV in dd water at 21 and 30 degrees C were very similar (between 0.12 and 0.14 log(10) per day), while MS2 was three-fold slower. In tap water (chlorine content between 4 and 5 ppm) at 21 degrees C, VEE and SV were inactivated at twice the rate measured in dd water. Conclusions: The inactivation rates of VEE and SV were similar to each other and faster than MS2 in all liquids tested. Significance and Impact of the Study: VEE is likely to remain viable for many days after release into water, snow, or even chlorinated tap water. SV can be used to estimate the persistence of VEE in liquids, but using MS2 as a simulant would overestimate of the stability of VEE. C1 [Sagripanti, J. -L.] USA, Edgewood Chem Biol Ctr, Res Engn & Dev Command, Aberdeen Proving Ground, MD 21010 USA. [Fitzgibbon, J. E.] NIH, Div Aids, Therapeut Res Program, Drug Dev & Clin Sci Branch, Bethesda, MD 20892 USA. RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, Res Engn & Dev Command, AMSRD ECB RT 5183 Blackhawk Rd,Edgewood Area, Aberdeen Proving Ground, MD 21010 USA. EM joseluis.sagripanti@us.army.mil FU US Department of Defense Chemical and Biological Defense; Defense Threat Reduction Agency; In-House Laboratory Independent Research (ILIR); Research and Technology Directorate, Edgewood Chemical Biological Center, Research Development and Engineering Command, US Army FX We gratefully acknowledge Dr Mike Parker of USAMRIID for supplying the VEE TC-83 virus. This work was supported by the US Department of Defense Chemical and Biological Defense program administered by the Defense Threat Reduction Agency and by In-House Laboratory Independent Research (ILIR) funds from the Research and Technology Directorate, Edgewood Chemical Biological Center, Research Development and Engineering Command, US Army. NR 24 TC 4 Z9 4 U1 2 U2 5 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1364-5072 J9 J APPL MICROBIOL JI J. Appl. Microbiol. PD NOV PY 2008 VL 105 IS 5 BP 1477 EP 1483 DI 10.1111/j.1365-2672.2008.03919.x PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 361FP UT WOS:000260113200026 PM 19146486 ER PT J AU Kanel, GI Bless, SJ Savinykh, AS Razorenov, SV Chen, T Rajendran, A AF Kanel, G. I. Bless, S. J. Savinykh, A. S. Razorenov, S. V. Chen, T. Rajendran, A. TI To the mechanisms of failure wave SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SHOCK COMPRESSION; GLASSES AB Results of shock-wave experiments with free and prestressed samples of K8 and K14 crown glasses are presented. Controlled confinement pressure on the specimen of around 200 MPa was provided by installing a shrink-fit metal sleeve on the lateral surface of the sample disk. Results of measurements of the free surface velocity histories show that prestressing leads to earlier stopping of the failure wave. Thus, the compressive transverse stress increases the failure threshold that is in agreement with existing criteria of compressive fracture. However, sensitivity of the failure threshold to the confinement stress value is not as high as it could be expected. Measurements of the refractive indexes for the particles from the failure wave zone of recovered glass samples have shown their small increase whereas no index change for particles from the residual zone was found. It has been concluded that irreversible densification makes essential contribution to the mechanism of failure of glasses. (C) 2008 American Institute of Physics. [DOI: 10.1063/1.3006131] C1 [Kanel, G. I.] Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia. [Bless, S. J.; Chen, T.] Univ Texas Austin, Inst Adv Technol, Austin, TX 78759 USA. [Savinykh, A. S.; Razorenov, S. V.] Joint Inst High Temp, Moscow 125412, Russia. [Rajendran, A.] USA, Res Off, RTP, Res Triangle Pk, NC 27709 USA. RP Kanel, GI (reprint author), Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia. EM kanel@ficp.ac.ru RI Kanel, Gennady/K-1657-2013; Razorenov, Sergei/O-6450-2014 FU U. S. Army Research Office through CRDF GAP [RUE2-1615-MO-06]; U. S. Office of Naval Research [N0014-06-01-0475] FX The work was supported by the U. S. Army Research Office through CRDF GAP Grant No. RUE2-1615-MO-06 and the U. S. Office of Naval Research through Grant No. N0014-06-01-0475. NR 13 TC 2 Z9 2 U1 1 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 2008 VL 104 IS 9 AR 093509 DI 10.1063/1.3006131 PG 6 WC Physics, Applied SC Physics GA 372ZV UT WOS:000260941700027 ER PT J AU Cappaert, TA Stone, JA Castellani, JW Krause, BA Smith, D Stephens, BA AF Cappaert, Thomas A. Stone, Jennifer A. Castellani, John W. Krause, Bentley Andrew Smith, Daniel Stephens, Bradford A. TI National Athletic Trainers' Association Position Statement: Environmental Cold Injuries SO JOURNAL OF ATHLETIC TRAINING LA English DT Review DE environmental physiology; hypothermia; frostbite; frostnip; chilblain; pernio; immersion foot; trench foot ID SPINAL-CORD-INJURY; HUMAN THERMOREGULATORY RESPONSES; EXERCISE-INDUCED BRONCHOSPASM; SKIN BLOOD-FLOW; WATER IMMERSION; THERMAL RESPONSES; PHYSIOLOGICAL-RESPONSES; TEMPERATURE REGULATION; METABOLIC-RESPONSES; ANOREXIA-NERVOSA AB Objective: To present recommendations for the prevention, recognition, and treatment of environmental cold injuries. Background: Individuals engaged in sport-related or work-related physical activity in cold, wet, or windy conditions are at risk for environmental cold injuries. An understanding of the physiology and pathophysiology, risk management, recognition, and immediate care of environmental cold injuries is an essential skill for certified athletic trainers and other health care providers working with individuals at risk. Recommendations: These recommendations are intended to provide certified athletic trainers and others participating in athletic health care with the specific knowledge and problem-solving skills needed to address environmental cold injuries. Each recommendation has been graded (A, B, or C) according to the Strength of Recommendation Taxonomy criterion scale. C1 [Cappaert, Thomas A.] Cent Michigan Univ, Mt Pleasant, MI 48859 USA. [Castellani, John W.] USA, Inst Environm Med, Natick, MA 01760 USA. [Krause, Bentley Andrew] Ohio Univ, Athens, OH 45701 USA. [Smith, Daniel] US Luge Assoc, Lake Placid, NY USA. [Stephens, Bradford A.] Lake Placid Sports Med, Lake Placid, NY USA. RP Cappaert, TA (reprint author), Natl Athlet Trainers Assoc, Dept Commun, 2952 Stemmons Freeway, Dallas, TX 75247 USA. RI Cappaert, Thomas/K-2725-2012 NR 125 TC 17 Z9 17 U1 4 U2 9 PU NATL ATHLETIC TRAINERS ASSOC INC PI DALLAS PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA SN 1062-6050 J9 J ATHL TRAINING JI J. Athl. Train. PD NOV-DEC PY 2008 VL 43 IS 6 BP 640 EP 658 DI 10.4085/1062-6050-43.6.640 PG 19 WC Sport Sciences SC Sport Sciences GA 377RN UT WOS:000261268400011 PM 19030143 ER PT J AU Lee, JW Kim, JG Mahon, S Tromberg, BJ Ryan, KL Convertino, VA Rickards, CA Osann, K Brenner, M AF Lee, Jangwoen Kim, Jae G. Mahon, Sari Tromberg, Bruce J. Ryan, Kathy L. Convertino, Victor A. Rickards, Caroline A. Osann, Kathryn Brenner, Matthew TI Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE hemorrhagic shock; lower body negative pressure; hemodynamic decompensation ID BODY NEGATIVE-PRESSURE; PHOTON MIGRATION SPECTROSCOPY; TIDAL CARBON-DIOXIDE; TRAUMA TRIAGE RULE; BLOOD-PRESSURE; HEMORRHAGIC-SHOCK; FREQUENCY-DOMAIN; NEOADJUVANT CHEMOTHERAPY; SCATTERING PROPERTIES; OXYGEN-SATURATION AB We demonstrate noninvasive near-infrared diffuse optical spectroscopy (DOS) measurements of tissue hemoglobin contents that can track progressive reductions in central blood volume in human volunteers. Measurements of mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), and cardiac output (Q) are obtained in ten healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Simultaneous quantitative noninvasive measurements of tissue oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin concentration (THb), and tissue hemoglobin oxygen saturation (S(t)O(2)) are performed throughout LBNP application using broadband DOS. As progressively increasing amounts of LBNP are applied, HR increases, and MAP, SV, and Q decrease (p < 0.001). OHb, S(t)O(2), and THb decrease (p < 0.001) in correlation with progressive increases in LBNP, while tissue RHb remained relatively constant (p=0.378). The average fractional changes from baseline values in DOS OHb (fOHb) correlate closely with independently measured changes in SV (r(2)=0.95) and Q (r(2)=0.98) during LBNP. Quantitative noninvasive broadband DOS measurements of tissue hemoglobin parameters of peripheral perfusion are capable of detecting progressive reductions in central blood volume, and appear to be sensitive markers of early hypoperfusion associated with hemorrhage as simulated by LBNP. (c) 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3041712] C1 [Lee, Jangwoen; Kim, Jae G.; Mahon, Sari; Tromberg, Bruce J.; Brenner, Matthew] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92612 USA. [Ryan, Kathy L.; Convertino, Victor A.; Rickards, Caroline A.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Osann, Kathryn] Univ Calif Irvine, Dept Med, Irvine, CA 92612 USA. [Brenner, Matthew] Univ Calif Irvine, Med Ctr, Pulm & Crit Care Div, Orange, CA 92868 USA. RP Lee, JW (reprint author), Univ Calif Irvine, Beckman Laser Inst & Med Clin, 1002 Hlth Sci Rd E, Irvine, CA 92612 USA. EM mbrenner@uci.edu FU NCI NIH HHS [P30 CA062203] NR 59 TC 6 Z9 7 U1 0 U2 2 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 J9 J BIOMED OPT JI J. Biomed. Opt. PD NOV-DEC PY 2008 VL 13 IS 6 AR 064027 DI 10.1117/1.3041712 PG 10 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 403RY UT WOS:000263100900032 PM 19123673 ER PT J AU Nesti, LJ Jackson, WM Shanti, RM Koehler, SM Aragon, AB Bailey, JR Sracic, MK Freedman, BA Giuliani, JR Tuan, RS AF Nesti, Leon J. Jackson, Wesley M. Shanti, Rabie M. Koehler, Steven M. Aragon, Amber B. Bailey, James R. Sracic, Michael K. Freedman, Brett A. Giuliani, Jeffrey R. Tuan, Rocky S. TI Differentiation Potential of Multipotent Progenitor Cells Derived from War-Traumatized Muscle Tissue SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID MESENCHYMAL STEM-CELLS; BONE-MARROW; STROMAL CELLS; CARTILAGE; IDENTIFICATION; REGENERATION; FRACTURES; INJURY; MICE AB Background: Recent military conflicts have resulted in numerous extremity injuries requiring complex orthopaedic reconstructive procedures, which begin with a thorough debridement of all contaminated and necrotic tissue in the zone of injury. The site of injury is also the site of healing, and we propose that debrided muscle tissue contains cells with robust reparative and regenerative potential. Methods: Debrided muscle from soldiers who had sustained traumatic open extremity injuries was collected during surgical debridement procedures at Walter Reed Army Medical Center. With modifications to a previously described stem-cell-isolation protocol, mesenchymal progenitor cells were harvested from traumatized muscle, enriched, expanded in culture, and exposed to induction media for osteogenesis, adipogenesis, and chondrogenesis. Results: The isolated mesenchymal progenitor cells stained positive for cell-surface markers (CD73, CD90, CD105), which are characteristic of adult human mesenchymal stem cells. Histological identification of lineage-specific markers demonstrated the potential of these cells to differentiate into multiple mesenchymal lineages. Reverse transcription-polymerase chain reaction analysis confirmed multilineage mesenchymal differentiation at the gene-expression level. Conclusions: To our knowledge, the present report provides the first description of mesenchymal progenitor cell isolation from traumatized human muscle. These cells may play an integral role in tissue repair and regeneration and merit additional investigation as they could be useful in future cell-based tissue-engineering strategies. Clinical Significance: Mesenchymal progenitor cells isolated from war-traumatized tissues have the potential for applications in cell-based tissue engineering. Elucidating the cellular mechanisms regulating their differentiation activities may lead to the development of novel treatments for musculoskeletal trauma and pathological healing responses, such as heterotopic ossification. C1 [Jackson, Wesley M.; Shanti, Rabie M.; Koehler, Steven M.; Aragon, Amber B.; Giuliani, Jeffrey R.; Tuan, Rocky S.] NIAMSD, Cartilage Biol & Orthopaed Branch, US Dept HHS, NIH, Bethesda, MD 20892 USA. [Bailey, James R.; Sracic, Michael K.] Uniformed Serv Univ Hlth Sci, Washington, DC USA. [Freedman, Brett A.] Walter Reed Army Med Ctr, Integrated Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Nesti, LJ (reprint author), 6900 Georgia Ave NW,Bldg 2,Room 5B28, Washington, DC 20307 USA. EM leonnesti@gmail.com FU Military Amputee Research Program [P05-A011]; NIH; NIAMS [Z01 AR41131] FX In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the Military Amputee Research Program at Walter Reed Army Medical Center (P05-A011) and by the Intramural Research Program at the NIH, NIAMS (Z01 AR41131). Neither they nor a member of their immediate families received payments or other benefits ora commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families. are affiliated or associated. NR 28 TC 80 Z9 84 U1 0 U2 3 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 USA SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD NOV PY 2008 VL 90A IS 11 BP 2390 EP 2398 DI 10.2106/JBJS.H.00049 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 372NA UT WOS:000260907100009 PM 18978407 ER PT J AU Mason, AD AF Mason, Arthur D., Jr. TI Invited Critique: The 2007 NBR Report: A Synopsis of the 2007 Call for Data SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article C1 [Mason, Arthur D., Jr.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Mason, AD (reprint author), 110 Rio Bravo, San Antonio, TX 78232 USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD NOV-DEC PY 2008 VL 29 IS 6 BP 871 EP 871 DI 10.1097/BCR.0b013e31818cb087 PG 1 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 372ZD UT WOS:000260939900003 ER PT J AU Davis, J Animashaun, A Schoenherr, E McDowell, K AF Davis, James Animashaun, Asisat Schoenherr, Edward McDowell, Kaleb TI Evaluation of Semi-Autonomous Convoy Driving SO JOURNAL OF FIELD ROBOTICS LA English DT Article ID ADAPTIVE CRUISE CONTROL; AUTOMATION; PERFORMANCE; WORKLOAD AB Autonomous mobility technologies may have applications to manned vehicle convoy operations-they have the ability to enhance both system performance and operator capability. This effort examines the potential impact of introducing semi-autonomous mobility [Convoy Active Safety Technologies (CAST)] into manned vehicles. Twelve civilians with experience driving military vehicles in convoy-type operations participated in this experiment. For the experiment, they were tasked with following a lead vehicle while completing a concurrent security task (scanning the local environment for targets). The control of the manned vehicle was varied between CAST and manual control at several different speed levels. Several objective speed and accuracy variables along with subjective operator assessment variables were examined for each task. The results support the potential benefits of incorporating semi-autonomous mobility technologies into manned vehicle convoy operations. The semi-autonomous mobility system was associated with significantly better performance in several aspects of operator situational awareness and convoy integrity, including enhanced target identification, improved maintenance of following distance, and improved performance for unanticipated stops. This experiment also highlighted a critical human factors issue associated with the incorporation Of autonomy in real-world applications: participants felt that, overall, they outperformed the semi-autonomous system on the simulated convoy operation. The operator's perception of the system's performance could potentially affect his or her willingness to use the system in real-world applications. This experiment demonstrated that enhancements to overall system performance in real-world applications are achieved by considering both technological and human factors solutions. Published 2008 Wiley Periodicals, lnc.* C1 [Davis, James; Animashaun, Asisat; McDowell, Kaleb] USA, Res Lab, Aberdeen Proving Ground, MD 21001 USA. [Schoenherr, Edward] USA, Tank & Automot Res Dev & Engn Ctr, Warren, MI 48397 USA. RP Davis, J (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21001 USA. EM james.davis@arl.army.mil; aanimashaun@arl.army.mil; edward.schoenherr@us.army.mil; kmcdowell@arl.army.mil RI McDowell, Kaleb/A-3410-2009 NR 38 TC 7 Z9 7 U1 0 U2 7 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1556-4959 EI 1556-4967 J9 J FIELD ROBOT JI J. Field Robot. PD NOV-DEC PY 2008 VL 25 IS 11-12 BP 880 EP 897 DI 10.1002/rob.20263 PG 18 WC Robotics SC Robotics GA 382BK UT WOS:000261579600002 ER PT J AU Oster, BG Timpe, RC Aulich, TR Lin, MCJ Holcomb, FH AF Oster, Benjamin G. Timpe, Ronald C. Aulich, Ted R. Lin, Mike C. J. Holcomb, Franklin H. TI On-Demand Hydrogen via High-Pressure Water Reforming for Military Fuel Cell Applications SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article DE on-demand hydrogen; JP-8; fuel cell; reforming; hydrogen economy AB Researchers have developed a high-pressure water-reforming (HPWR) process that produces high-pressure hydrogen from a jet fuel feedstock. Converting petroleum-based fuels to hydrogen for fuel cell use is a unique approach to reducing military petroleum consumption by improving petroleum utilization efficiency. HPWR is an attractive option because, unlike traditional steam methane reforming, it does not require postreformer hydrogen compression and storage. A HPWR apparatus was designed and manufactured. Several catalysts were tested for their ability to produce high-pressure hydrogen from jet fuel. S-8, which is a jet fuel derived from natural gas, was used as a model feedstock for initial experiments because the fuel is sulfur and aromatics free. After optimizing with S-8, JP-8 will be utilized for future experiments. The most promising catalyst produced a 4000 psi (gauge) product gas stream that contained 54 mol % hydrogen. These experimental results show that HPWR is a promising solution for high-pressure hydrogen production as a key step toward reducing military petroleum use. C1 [Oster, Benjamin G.; Timpe, Ronald C.; Aulich, Ted R.] Univ N Dakota, Energy & Environm Res Ctr, Grand Forks, ND 58202 USA. [Lin, Mike C. J.; Holcomb, Franklin H.] USA, Construct Engn Res Lab, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. RP Oster, BG (reprint author), Univ N Dakota, Energy & Environm Res Ctr, 15 N 23rd St,Stop 9018, Grand Forks, ND 58202 USA. EM boster@undeerc.org; rtimpe@undeerc.org; taulich@undeerc.org; m-lin@cecer.army.mil; franklin.h.holcomb@erdc.usace.army.mil NR 11 TC 1 Z9 1 U1 0 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD NOV PY 2008 VL 5 IS 4 AR 044501 DI 10.1115/1.2931460 PG 4 GA 359EM UT WOS:000259969200017 ER PT J AU Sathunuru, R Melendez, V Kozar, MP Lin, AJ AF Sathunuru, Ramadas Melendez, Victor Kozar, Michael P. Lin, Ai J. TI A Facile One Pot Synthesis of 2,4-Diamino-6-substituted s-Triazine Derivatives SO JOURNAL OF HETEROCYCLIC CHEMISTRY LA English DT Article ID IMIDAZOLIDINEDIONE DERIVATIVES; MALARIA; ISOTHIOCYANATES; INHIBITORS AB A novel and facile one-pot procedure for the preparation of 2,4-diamino-6-substituted-s-triazine derivatives (IIa-n) was reported. The scope of its application was demonstrated with a number of examples. The new procedure involved treatment of proguanil or chloroproguanil with acyl chloride or alky chlorooxoacetate in pyridine at ice cold temperature followed by reflux overnight to give good yields of the desired products. C1 [Sathunuru, Ramadas; Melendez, Victor; Kozar, Michael P.; Lin, Ai J.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Lin, AJ (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RI Kozar, Michael/A-9155-2011 FU Military Infections Diseases Research Program [A40096_06_WR_CSPP]; U.S. Army Medical Research and Material Cormnand, Department of Defense, USA.; Peer Reviewed Medical Research Program (PRMRP) [PR054609]; Malaria and Medicine Venture (MMV), Geneva, Switzerland; [MMV04/0013] FX Material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publications. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as official, or as reflecting true views of the Department of the Army or the Department of Defense. This research is supported in part by funding from Military Infections Diseases Research Program (A40096_06_WR_CSPP), U.S. Army Medical Research and Material Cormnand, Department of Defense, USA., Peer Reviewed Medical Research Program (PRMRP) (Grant # PR054609), and Malaria and Medicine Venture (MMV), Geneva, Switzerland, (Grant # MMV04/0013). NR 20 TC 0 Z9 0 U1 1 U2 2 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-152X J9 J HETEROCYCLIC CHEM JI J. Heterocycl. Chem. PD NOV-DEC PY 2008 VL 45 IS 6 BP 1673 EP 1678 PG 6 WC Chemistry, Organic SC Chemistry GA 374XS UT WOS:000261077600018 ER PT J AU Wolfenstine, J Allen, JL AF Wolfenstine, J. Allen, J. L. TI Reaction of Li(0.33)La(0.57)TiO(3) with water SO JOURNAL OF MATERIALS SCIENCE LA English DT Letter ID IONIC-CONDUCTIVITY; LITHIUM; CERAMICS; TITANATE C1 [Wolfenstine, J.; Allen, J. L.] USA, Res Lab, AMSRD ARL SE DC, Adelphi, MD 20783 USA. RP Wolfenstine, J (reprint author), USA, Res Lab, AMSRD ARL SE DC, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM jwolfenstine@arl.army.mil NR 18 TC 11 Z9 11 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD NOV PY 2008 VL 43 IS 22 BP 7247 EP 7249 DI 10.1007/s10853-008-3048-5 PG 3 WC Materials Science, Multidisciplinary SC Materials Science GA 373FZ UT WOS:000260957700030 ER PT J AU Kochary, F Aggarwal, MD Batra, AK Hawrami, R Lianos, D Burger, A AF Kochary, F. Aggarwal, M. D. Batra, A. K. Hawrami, R. Lianos, D. Burger, A. TI Growth and electrical characterization of the lead magnesium niobate-lead titanate (PMN-PT) single crystals for piezoelectric devices SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article ID TEMPERATURE SOLUTION GROWTH; PBTIO3; 1ST-PRINCIPLES; CERAMICS AB The lead magnesium niobate-lead titanate is one of the new generations of piezoelectric materials with outstanding properties. Single crystals of 0.67Pb(Mg(1/3)Nb(2/3))O(3)-0.33PbTiO(3) (PMN-PT) show superior properties as compared to piezoelectric ceramics and piezoelectric films in device applications. Large size crystals are required for specific applications. Previously, transparent and high quality PMN-PT single crystals have been grown in our laboratory using the high temperature flux method. The size of the obtained crystals was small and varied from 2 to 8 mm(3), mostly showing regular prismatic shape. In present attempt, PMN-PT crystals are grown from the vertical gradient freeze method with no flux using congruent melt. Processing conditions and growth parameters have been optimized to increase the size and yield of the perovskite crystals including cooling rate, soak time and soak temperature. The size of the grown crystals obtained by this method is very large relatively and varied from 5 to 30 mm(3). The microstructure of the as grown single crystals is investigated by scanning electron microscopy. Piezoelectric properties of the grown crystals are also investigated. PMN-PT plates show excellent piezoelectric properties. Samples were poled under an applied electric field of 5 kV/cm. Dielectric properties at a frequency of 1 kHz are examined. Finally, the variation of pyroelectric coefficient with temperature is studied. The grown PMN-PT crystals show typical relaxor dielectric properties. C1 [Kochary, F.; Aggarwal, M. D.; Batra, A. K.; Hawrami, R.] Alabama A&M Univ, Dept Phys, Normal, AL 35762 USA. [Lianos, D.] USA, SMDC, Huntsville, AL 35805 USA. [Burger, A.] Fisk Univ, Dept Phys, Nashville, TN 37208 USA. RP Kochary, F (reprint author), Alabama A&M Univ, Dept Phys, 4900 Meridian St,POB 1268, Normal, AL 35762 USA. EM fkochary@gmail.com FU NSF-HBCU-RISE [HRD-0531183]; U. S. Army Space and Missile Defense Command [W9113M-04-C-0005]; United Negro College Fund Special Program (UNCFSP) [NNG06GC58A] FX This work was supported under the NSF-HBCU-RISE program HRD-0531183 and U. S. Army Space and Missile Defense Command, contract # W9113M-04-C-0005. One of the authors (MDA) would like to acknowledge support from NASA administrator's Fellowship Program (NAFP) through United Negro College Fund Special Program (UNCFSP) corporation under their contract # NNG06GC58A. NR 26 TC 6 Z9 6 U1 1 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD NOV PY 2008 VL 19 IS 11 BP 1058 EP 1063 DI 10.1007/s10854-007-9459-2 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA 338TU UT WOS:000258532900006 ER PT J AU Turell, MJ Sardelis, MR Jones, JW Watts, DM Fernandez, R Garbajal, F Pecor, JE Klein, TA AF Turell, Michael. J. Sardelis, Michael R. Jones, James W. Watts, Douglas M. Fernandez, Roberto Garbajal, Faustino Pecor, James E. Klein, Terry A. TI Seasonal Distribution, Biology, and Human Attraction Patterns of Mosquitoes (Diptera: Culicidae) in a Rural Village and Adjacent Forested Site Near Iquitos, Peru SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Anopheles; bionomics; mosquito ecology; Amazon Basin; Peru ID AMAZON BASIN REGION; ANOPHELES-DARLINGI; PLASMODIUM-FALCIPARUM; MALARIA TRANSMISSION; VECTOR COMPETENCE; SOUTH-AMERICA; VIRUS; BRAZIL; RONDONIA; SUSCEPTIBILITY AB This study was conducted as part of a field-ecology study of arboviral and malarial activity in the Amazon Basin, Loreto Department, Peru. to determine the relative abundance, species diversity. and seasonal and vertical distributions of potential mosquito vectors. Mosquitoes were captured either by volunteers using mouth aspirators while mosquitoes attempted to land on the collectors or in dry ice-baited ABC light traps. Anopheles darlingi, the principal malaria vector in the region, was the most commonly captured anopheline mosquito in Puerto Almendra village (99%) while landing oil humans, with a mean of 37.1 mosquitoes captured per 24-h period, representing nearly one half of all mosquitoes collected. An. darlingi human landing activity began shortly after sunset, peaked at 2000-2100 hours, and declined gradually until sunrise. This species readily entered houses, because 51% of the An. darlingi captured by paired collectors, stationed inside and outside houses, were captured indoors. Human landing collections provided a more accurate estimate of human attraction of An. darlingi, capturing 30 tunes as many as co-located dry ice-baited ABC light traps. In contrast, eight times as many Culex (Melanoconion) species, including known arbovirus vectors, were captured in light traps as by co-located human collectors. Despite being located within 300 in of the village collection site, only a few Anopheles species were captured at the forest collection site, including only 0.1 Andarlingi/24 h, thus indicating that An. darlingi activity was directly associated with the rural village. These data provide a better understanding of the taxonomy, population density, and seasonal distribution of potential mosquito vectors of disease within the Amazon Basin region and allow for the development of appropriate vector and disease prevention strategies that target vector populations. C1 [Turell, Michael. J.; Sardelis, Michael R.; Jones, James W.; Watts, Douglas M.; Fernandez, Roberto; Garbajal, Faustino; Pecor, James E.; Klein, Terry A.] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Turell, MJ (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM michael.turell@amess.army.mil RI Valle, Ruben/A-7512-2013 FU U.S. Navy [62787A870U8517] FX We thank M. Wooster, K. Block, A. Gozalo, H. Astete, Naval Medical Research Center. and Detachment-Peru for technical support; C. Calampa, Director de la Region de Salud de Loreto, Ministry of Health, Iquitos. Peru, for assistance R, Wilkerson, and E. L. Peyton, Walter Reed Army Medical Institute of Research, for providing taxonomic assistance; A. Anderson for providing guidance on obtaining the Human-Use Protocol, K. Kenyon foi expert editorial assistance L. Farinick for illustrations: and G. Korch for support and helpful suggestions. This work was supported by Work Unit 62787A870U8517 of the U.S. Navy. NR 40 TC 13 Z9 13 U1 0 U2 8 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 2008 VL 45 IS 6 BP 1165 EP 1172 DI 10.1603/0022-2585(2008)45[1165:SDBAHA]2.0.CO;2 PG 8 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 368ZA UT WOS:000260661000027 PM 19058644 ER PT J AU Han, Y Sukhishvili, S Du, H Cefaloni, J Smolinsko, B AF Han, Yun Sukhishvili, Svetlana Du, Henry Cefaloni, John Smolinsko, Benjamin TI Layer-by-Layer Self-Assembly of Oppositely Charged Ag Nanoparticles on Silica Microspheres for Trace Analysis of Aqueous Solutions Using Surface-Enhanced Raman Scattering SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE Ag Nanoparticles; Layer-by-Layer Assembly; Raman Scattering ID GOLD NANOPARTICLES; SINGLE-MOLECULE; SILVER ELECTRODE; COLLOIDAL PARTICLES; THIN-FILMS; SERS; SPECTROSCOPY; SPHERES; SPECTRA; NANOSHELLS AB A layer-by-layer (LbL) self-assembly strategy involving oppositely charged Ag nanoparticles was used to deposit a nanoshell of Ag nanoparticles on silica microspheres for trace chemical measurements in aqueous solutions by means of surface-enhanced Raman scattering (SERS). Positively charged Ag nanoparticles were produced by reduction of Ag nitrate in a solution mixture of branched polyethyleneimine (BPEI) and N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid (HEPES) under UV irradiation whereas negatively charged Ag nanoparticles were synthesized by the conventional citrate reduction method. The density of Ag nanoparticles in the nanoshell exhibits a strong correlation with the layer number and the nanoparticle type. Thiocyanate (SCN(-)) and crystal violet and were used as model positively and negatively charged analytes respectively to assess the robustness of the resultant core-shell nanostructures for SERS measurements. High sensitivity, at ppt for crystal violet and ppb for SCN(-), was obtained when the surface charge of the terminating Ag layer in the LbL self-assembled nanoshell was opposite to the ionic nature of the analyte of interest due to enhanced adsorption of the analyte to the Ag nanoparticles facilitated by strong electrostatic attraction. The microsphere-nanoshell structures were all individually SERS-active, making them excellent candidate platform for integration with microfluidic systems for in situ SERS-based sensing and measurements. C1 [Sukhishvili, Svetlana] Stevens Inst Technol, Dept Chem & Chem Biol, Hoboken, NJ 07030 USA. [Han, Yun; Du, Henry] Stevens Inst Technol, Dept Chem Biomed & Mat Engn, Hoboken, NJ 07030 USA. [Smolinsko, Benjamin] USA, Armament Res Dev & Engn Ctr, Energet Warheads & Environm Technol Directorate, Picatinny Arsenal, NJ 07806 USA. RP Sukhishvili, S (reprint author), Stevens Inst Technol, Dept Chem & Chem Biol, Hoboken, NJ 07030 USA. RI han, yun/F-1588-2011 FU National Science Foundation [ECS-0404002]; US Army RDECOM-ARDEC FX We thank Dr. Denis Pristinski of our research group for valuable assistance in the Raman measurement part of this study. This work was supported by the National Science Foundation under grant number ECS-0404002 and by the US Army RDECOM-ARDEC. NR 65 TC 18 Z9 20 U1 4 U2 42 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1533-4880 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD NOV PY 2008 VL 8 IS 11 BP 5791 EP 5800 DI 10.1166/jnn.2008.221 PG 10 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 379IV UT WOS:000261390800029 PM 19198307 ER PT J AU Delaney, HM Praumer, RD Person, DA AF Delaney, Heather M. Praumer, Ronald D. Person, Donald A. TI Germline p53 Mutation in a Micronesian Child With Adrenocortical Carcinoma and Subsequent Osteosarcoma SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE adrenocortical carcinoma; osteosarcoma; p53 germline mutation ID TUMOR-SUPPRESSOR GENE; SOFT-TISSUE SARCOMAS; LI-FRAUMENI-SYNDROME; FAMILIAL SYNDROME; BREAST-CANCER; TP53 MUTATION; NEOPLASMS; BONE; IMPACT AB In 1990, an 18-month-old Micronesian girl was initially diagnosed with a right adrenocortical carcinoma. More than a decade later (2003), she was diagnosed with metastatic osteosarcoma with the primary in her right proximal fibula. Given this child's remarkable history of malignancy, she underwent testing for a genetic mutation that is associated with increased cancer formation. One such cancer syndrome is called Li-Fraumeni syndrome where approximately 70% of patients carry a genetic mutation in the p53 tumor suppressor gene. Patients with LFS are at risk for developing cancers of the breast, soft tissues, brain, bone, adrenal gland, and blood cells. Mutational analysis of out patient did reveal the presence of a germline mutation of the p53 tumor suppressor gene. She was found to have a base pair change (A -> C) at nucleotide 394 resulting in a lysine to glutamine amino acid change at condon 132 (K 132Q), which remarkably has never been described in association with either adrenocortical carcinoma or osteosarcoma. C1 [Delaney, Heather M.; Praumer, Ronald D.; Person, Donald A.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. [Person, Donald A.] Pacific Isl Hlth Care Project, Dept Clin Invest, Honolulu, HI USA. RP Delaney, HM (reprint author), Tripler Army Med Ctr, Dept Pediat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM delane@amedd.army.mil NR 18 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1077-4114 J9 J PEDIAT HEMATOL ONC JI J. Pediatr. Hematol. Oncol. PD NOV PY 2008 VL 30 IS 11 BP 803 EP 806 DI 10.1097/MPH.0b013e31818ab288 PG 4 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA 369XK UT WOS:000260727000004 PM 18989156 ER PT J AU Chen, SE Young, D Hutchens, M Anthony, RW Cohen, JM Mlakar, P AF Chen, Shen-En Young, David Hutchens, Maie Anthony, Ronald W. Cohen, Julie Mark Mlakar, Paul TI Students' Recommendations for the Guidelines for Failure Investigation SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article C1 [Chen, Shen-En; Young, David] Univ N Carolina, Dept Civil Engn, Charlotte, NC 28223 USA. [Hutchens, Maie] McKim & Creed, Charlotte, NC 28227 USA. [Anthony, Ronald W.] Comm Forens Invest Tech Council Forens Engn, Ft Collins, CO 80527 USA. [Anthony, Ronald W.] Anthony & Associates Inc, Ft Collins, CO 80527 USA. [Mlakar, Paul] USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Chen, SE (reprint author), Univ N Carolina, Dept Civil Engn, 9201 Univ City Blvd, Charlotte, NC 28223 USA. NR 40 TC 1 Z9 1 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD NOV-DEC PY 2008 VL 22 IS 6 BP 353 EP 355 DI 10.1061/(ASCE)0887-3828(2008)22:6(353) PG 3 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 372ZE UT WOS:000260940000002 ER PT J AU Lentz, SJ Fewings, M Howd, P Fredericks, J Hathaway, K AF Lentz, Steven J. Fewings, Melanie Howd, Peter Fredericks, Janet Hathaway, Kent TI Observations and a Model of Undertow over the Inner Continental Shelf SO JOURNAL OF PHYSICAL OCEANOGRAPHY LA English DT Article ID SURF ZONE; VERTICAL STRUCTURE; OCEAN CIRCULATION; BOUNDARY-LAYER; FINITE DEPTH; WAVE-DRIVEN; WIND; FLOW; DYNAMICS; CURRENTS AB Onshore volume transport ( Stokes drift) due to surface gravity waves propagating toward the beach can result in a compensating Eulerian offshore flow in the surf zone referred to as undertow. Observed offshore flows indicate that wave-driven undertow extends well offshore of the surf zone, over the inner shelves of Martha's Vineyard, Massachusetts, and North Carolina. Theoretical estimates of the wave-driven offshore transport from linear wave theory and observed wave characteristics account for 50% or more of the observed offshore transport variance in water depths between 5 and 12 m, and reproduce the observed dependence on wave height and water depth. During weak winds, wave-driven cross-shelf velocity profiles over the inner shelf have maximum offshore flow (1-6 cm s(-1)) and vertical shear near the surface and weak flow and shear in the lower half of the water column. The observed offshore flow profiles do not resemble the parabolic profiles with maximum flow at middepth observed within the surf zone. Instead, the vertical structure is similar to the Stokes drift velocity profile but with the opposite direction. This vertical structure is consistent with a dynamical balance between the Coriolis force associated with the offshore flow and an along-shelf "Hasselmann wave stress" due to the influence of the earth's rotation on surface gravity waves. The close agreement between the observed and modeled profiles provides compelling evidence for the importance of the Hasselmann wave stress in forcing oceanic flows. Summer profiles are more vertically sheared than either winter profiles or model profiles, for reasons that remain unclear. C1 [Lentz, Steven J.; Fewings, Melanie; Fredericks, Janet] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA. [Howd, Peter] US Geol Survey, St Petersburg, FL USA. [Hathaway, Kent] USA, Corps Engineers, CHL Field Res Facil, Kitty Hawk, NC USA. RP Lentz, SJ (reprint author), Woods Hole Oceanog Inst, MS 21, Woods Hole, MA 02543 USA. EM slentz@whoi.edu RI Fewings, Melanie/F-6838-2013; OI Fewings, Melanie/0000-0003-2903-1620; Lentz, Steven/0000-0001-7498-0281 NR 45 TC 65 Z9 65 U1 2 U2 19 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-3670 J9 J PHYS OCEANOGR JI J. Phys. Oceanogr. PD NOV PY 2008 VL 38 IS 11 BP 2341 EP 2357 DI 10.1175/2008JPO3986.1 PG 17 WC Oceanography SC Oceanography GA 381TQ UT WOS:000261559200001 ER PT J AU Esquivel, J Nissan, A Stojadinovic, A AF Esquivel, Jesus Nissan, Aviram Stojadinovic, Alexander TI Cytoreductive Surgery and Heated Intra-Peritoneal Chemotherapy in the Treatment of Peritoneal Carcinomatosis of Colorectal Origin: The Need for Practice Altering Data SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Editorial Material ID HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; CANCER; FLUOROURACIL; LEUCOVORIN; IRINOTECAN; MANAGEMENT; TRIAL C1 [Stojadinovic, Alexander] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Esquivel, Jesus] St Agnes Hosp, Dept Surg, Baltimore, MD USA. [Nissan, Aviram] Hadassah Hebrew Univ Med Ctr, Dept Surg, Jerusalem, Israel. [Stojadinovic, Alexander] US Mil Canc Inst, Washington, DC USA. RP Stojadinovic, A (reprint author), Walter Reed Army Med Ctr, Dept Surg, 6900 Georgia Ave NW,Rm 5C27A, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.army.mil NR 5 TC 3 Z9 3 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD NOV 1 PY 2008 VL 98 IS 6 BP 397 EP 398 DI 10.1002/jso.21124 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 371SF UT WOS:000260850900001 PM 18780291 ER PT J AU Sawvel, RA Kim, B Alvarez, PJJ AF Sawvel, Russell A. Kim, Byung Alvarez, Pedro J. J. TI Removal of Volatile Organic Compounds at Extreme Shock-Loading Using a Scaled-Up Pilot Rotating Drum Biofilter SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article AB A pilot-scale rotating drum biofilter (RDB), which is a novel biofilter design that offers flexible flow-through configurations, was used to treat complex and variable volatile organic compound (VOC) emissions, including shock loadings, emanating from paint drying operations at an Army ammunition plant. The RDB was seeded with municipal wastewater activated sludge. Removal efficiencies up to 86% and an elimination capacity of 5.3 g chemical oxygen demand (COD) m(-3) center dot hr(-1) were achieved at a filter-medium contact time of 60 sec. Efficiency increased at higher temperatures that promote higher biological activity, and decreased at lower pH, which dropped down to pH 5.5 possibly as a result of carbon dioxide and volatile fatty acid production and ammonia consumption during VOC degradation. In comparison, other studies have shown that a bench-scale RDB could achieve a removal efficiency of 95% and elimination capacity of 331 g COD m(-1) center dot hr(-1). Sustainable performance of the pilot-scale RDB was challenged by the intermittent nature of painting operations, which typically resulted in 3-day long shutdown periods when bacteria were not fed. This challenge was overcome by adding sucrose (2 g/L weekly) as an auxiliary substrate to sustain metabolic activity during shutdown periods. C1 [Sawvel, Russell A.; Alvarez, Pedro J. J.] Univ Iowa, Dept Civil & Environm Engn, Iowa City, IA 52242 USA. [Kim, Byung] USA, ERDC CERL, Champaign, IL USA. RP Alvarez, PJJ (reprint author), Rice Univ, Dept Civil & Environm Engn, 6100 Main St,MS 317, Houston, TX 77005 USA. EM alvarez@rice.edu NR 6 TC 3 Z9 4 U1 1 U2 7 PU AIR & WASTE MANAGEMENT ASSOC PI PITTSBURGH PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA SN 1047-3289 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD NOV PY 2008 VL 58 IS 11 BP 1407 EP 1414 DI 10.3155/1047-3289.58.11.1407 PG 8 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 372FA UT WOS:000260886300003 PM 19044156 ER PT J AU Pollak, AN Ficke, CJR AF Pollak, Andrew N. Ficke, Col. James R. TI Extremity War Injuries: Challenges in Definitive Reconstruction Introduction SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Editorial Material C1 [Pollak, Andrew N.] Univ Maryland, Ctr Shock Trauma, Sch Med, Baltimore, MD 21201 USA. [Ficke, Col. James R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Ficke, Col. James R.] USA, Ft Sam Houston, TX USA. RP Pollak, AN (reprint author), Univ Maryland, Ctr Shock Trauma, Sch Med, Baltimore, MD 21201 USA. EM apollak@umoa.umm.edu; james.ficke@cen.amedd.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD NOV PY 2008 VL 16 IS 11 BP 626 EP 627 PG 2 WC Orthopedics SC Orthopedics GA 364UA UT WOS:000260359700002 PM 18978284 ER PT J AU Pollak, AN Ficke, CJR AF Pollak, Andrew N. Ficke, Col James R. TI Extremity War Injuries: Challenges in Definitive Reconstruction SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS LA English DT Article ID BONE MORPHOGENETIC PROTEIN-2; OPEN TIBIAL FRACTURES; ALLOGRAFT RECONSTRUCTION; EXTERNAL FIXATION; ELBOW ALLOGRAFT; SEGMENTAL BONE; FOLLOW-UP; DEFECTS; ARTHRODESIS; TRAUMA AB The third annual Extremity War Injuries Symposium was held in January 2008 to review challenges related to definitive management of severe injuries sustained primarily as a result of blast injuries associated with military operations in the Global War on Terror. Specifically, the symposium focused on the management of soft-tissue defects, segmental bone defects, open tibial shaft fractures, and challenges associated with massive periarticular reconstructions. Advances in several components of soft-tissue injury management, such as improvement in the use of free-tissue transfer and enhanced approaches to tissue-engineering, may improve overall care for extremity injuries. Use of distraction osteogenesis for treatment of large bone defects has been simplified by the development of computer-aided distraction protocols. For closed tibial fractures, evidence and consensus support initial splinting for transport and aeromedical evacuation, followed by elective reamed, locked intramedullary nail fixation. Management of open tibial shaft fractures sustained as a result of high-energy combat injuries should include serial debridements every 48 hours until definitive wound closure and stabilization are recommended. A low threshold is recommended for early utilization of fasciotomies in the overall treatment of tibial shaft fractures associated with war injuries. For management of open tibial fractures secondary to blast or high-velocity gunshot injuries, good experiences have been reported with the use of ring fixation for definitive treatment. Treatment options in any given case of massive periarticular defects must consider the specific anatomic and physiologic challenges presented as well as the capabilities of the treating surgeon. C1 [Pollak, Andrew N.] Univ Maryland, Sch Med, RAC Shock Trauma Ctr, Baltimore, MD 21201 USA. [Ficke, Col James R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Ficke, Col James R.] USA, Ft Sam Houston, TX USA. RP Pollak, AN (reprint author), Univ Maryland, Sch Med, RAC Shock Trauma Ctr, Room T3R54,22 S Greene St, Baltimore, MD 21201 USA. NR 43 TC 17 Z9 17 U1 2 U2 5 PU AMER ACAD ORTHOPAEDIC SURGEONS PI ROSEMENT PA 6300 N RIVER ROAD, ROSEMENT, IL 60018-4262 USA SN 1067-151X J9 J AM ACAD ORTHOP SUR JI J. Am. Acad. Orthop. Surg. PD NOV PY 2008 VL 16 IS 11 BP 628 EP 634 PG 7 WC Orthopedics SC Orthopedics GA 364UA UT WOS:000260359700003 PM 18978285 ER PT J AU Blaha, MD Leon, LR AF Blaha, Michael D. Leon, Lisa R. TI Effects of Indomethacin and Buprenorphine Analgesia on the Postoperative Recovery of Mice Response SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Letter C1 [Blaha, Michael D.; Leon, Lisa R.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Blaha, MD (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD NOV PY 2008 VL 47 IS 6 BP 8 EP 9 PG 2 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 380AR UT WOS:000261438400002 ER PT J AU Paliwal, B Ramesh, KT McCauley, JW Chen, MW AF Paliwal, Bhasker Ramesh, Kaliat T. McCauley, James W. Chen, Mingwei TI Dynamic Compressive Failure of AlON Under Controlled Planar Confinement SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID ALUMINUM OXYNITRIDE SPINEL; BRITTLE MATERIALS; LATERAL CONFINEMENT; MGAL2O4 SPINEL; DAMAGE MODEL; CERAMICS; PRESSURE; TEMPERATURE; PLASTICITY; STRENGTH AB An experimental technique is developed to impose a planar lateral confinement in a prismatic specimen (with a rectangular cross section); the setup enabled a controlled and homogeneous stress state with high lateral compressive stresses. A transparent polycrystalline aluminum oxynitride (AlON) specimen was used for the study. The statically precompressed specimen was then subjected to axial dynamic compressive loading using a modified compression Kolsky bar setup. Experimental design was performed using 3D computational modeling. Initial exploratory experiments were conducted on AlON at an average planar confinement of 400-410 MPa; the results suggested a higher compressive strength and a nonlinear stress evolution in AlON due to the confinement. A high-speed camera was used to observe the damage evolution in the specimen during the course of loading. The photographs and stress evolution are suggestive of an additional inelastic deformation mechanism, whose evolution is slower than the typical brittle-cracking type of damage apparent in the unconfined case. The TEM and high-resolution electron microscope analysis indicated dislocation plasticity in some fragments; dislocations in the slip bands were characterized to be dissociated < 110 > dislocations on {111} planes. The width between two partial dislocations was about 15 nm, suggesting low stacking fault energy of AlON. Microscopic characterization also shows that the eventual fragmentation of AlON is by cleavage mainly along low-index {111} planes. C1 [Paliwal, Bhasker; Ramesh, Kaliat T.; Chen, Mingwei] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [McCauley, James W.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21078 USA. [Chen, Mingwei] Tohoku Univ, WPI Adv Inst Mat Res, Tohoku, Japan. RP Paliwal, B (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM bpaliwal@jhu.edu RI Chen, Mingwei/A-4855-2010 OI Chen, Mingwei/0000-0002-2850-8872 FU Army Research Laboratory [W911NF-06-2-0006] FX This work was financially supported by the Army Research Laboratory under ARMAC-RTP Cooperative Agreement No. W911NF-06-2-0006. NR 43 TC 29 Z9 30 U1 2 U2 14 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD NOV PY 2008 VL 91 IS 11 BP 3619 EP 3629 DI 10.1111/j.1551-2916.2008.02712.x PG 11 WC Materials Science, Ceramics SC Materials Science GA 374SI UT WOS:000261063600023 ER PT J AU Cohen, SD Kimmel, PL Neff, R Agodoa, L Abbottt, KC AF Cohen, Scott D. Kimmel, Paul L. Neff, Robert Agodoa, Lawrence Abbottt, Kevin C. TI Association of Incident Gout and Mortality in Dialysis Patients SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the American-Society-of-Nephrology/Annual Renal Week CY OCT 31-NOV 05, 2007 CL San Francisco, CA SP Amer Soc Nephrol ID SERUM URIC-ACID; STAGE RENAL-DISEASE; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; MIDDLE-AGED MEN; HEMODIALYSIS-PATIENTS; CARDIOVASCULAR MORTALITY; RISK-FACTOR; FOLLOW-UP; METABOLIC SYNDROME AB Previous studies have shown that gout is associated with an increased risk for cardiovascular mortality in the general population, but this has not been well studied in patients with ESRD. In this study, the incidence of gout and its association with mortality was evaluated in 259,209 patients in the United States Renal Data System. Overall, the incidence of gout in the first year of dialysis was 5% and in the first 5 yr was 15.4%. Independent risk factors for gout in adjusted analyses included black race, older age, female gender, hypertension, ischemic heart disease, congestive heart failure, and alcohol use. Factors associated with a lower risk for gout included a history of diabetes, smoking, and peripheral vascular disease. Time-dependent Cox regression analysis suggested that an episode of gout was independently associated with a 1.5-fold increase in mortality risk (adjusted hazard ratio 1.49; 95% confidence interval 1.43 to 1.55). The mechanisms underlying this association require further study. C1 [Neff, Robert; Abbottt, Kevin C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Cohen, Scott D.; Kimmel, Paul L.] George Washington Univ, Med Ctr, Dept Med, Div Renal Dis, Washington, DC 20052 USA. [Agodoa, Lawrence] NIDDK, NIH, Bethesda, MD USA. [Neff, Robert; Abbottt, Kevin C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Abbottt, KC (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM kevin.abbott@amedd.army.mil OI Abbott, Kevin/0000-0003-2111-7112 NR 57 TC 39 Z9 42 U1 0 U2 0 PU AMER SOC NEPHROLOGY PI WASHINGTON PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA SN 1046-6673 J9 J AM SOC NEPHROL JI J. Am. Soc. Nephrol. PD NOV PY 2008 VL 19 IS 11 BP 2204 EP 2210 DI 10.1681/ASN.2007111256 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA 367YI UT WOS:000260588100021 PM 18508965 ER PT J AU Shuja, F Shults, C Duggan, M Tabbara, M Butt, MU Fischer, TH Schreiber, MA Tieu, B Holcomb, JB Sondeen, JL Demoya, M Velmahos, GC Alam, HB AF Shuja, Fahad Shults, Christian Duggan, Michael Tabbara, Malek Butt, Muhammad U. Fischer, Thomas H. Schreiber, Martin A. Tieu, Brandon Holcomb, John B. Sondeen, Jill L. deMoya, Marc Velmahos, George C. Alam, Hasan B. TI Development and Testing of Freeze-Dried Plasma for the Treatment of Trauma-Associated Coagulopathy SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 38th Annual Meeting of the Western-Trauma-Association CY FEB 24-29, 2008 CL Squaw Creek, CA DE Lyophilized; Freeze-dried; Plasma; Blood; Coagulopathy; Acidosis; Hypotherima; Multiple injuries; Resuscitation; Hemodilution; Liver injury; Femur fracture ID FRESH WHOLE-BLOOD; UNCONTROLLED HEMORRHAGIC-SHOCK; COAGULATION-FACTORS; LACTATED RINGERS; POOLED PLASMA; NORMAL SALINE; RESUSCITATION; TRANSFUSIONS; TEMPERATURE; MILITARY AB Background: Trauma-induced coagulopathy is associated with an extremely high mortality. We have recently shown that survival can be improved by correction of coagulopathy through early, aggressive infusion of Fresh Frozen Plasma (FFP). However, FFP is a perishable product, and its use is impractical in challenging environments such as a battlefield. Development of shelf-stable, easy to use, low volume, lyophilized, Freeze-Dried Plasma (FDP) can overcome the logistical limitations. We hereby report the development and testing of such a product. Methods: Plasma separated from fresh porcine blood (n = 10) was either stored as FFP, or lyophilized to produce the FDP. For in vitro testing, the FDP was rehydrated with distilled water and the pH, temperature, and osmolarity were adjusted to match the thawed FFP. Laboratory analysis included measurements of prothrombin time (PT), partial thromboplastin time, fibrinogen levels, and clotting factors II, VII, and IX. To test in vivo efficacy, swine were subjected to multiple injuries (femur fracture and grade V liver injury) and severe hemorrhagic shock (60% blood loss associated with "lethal triad" of coagulopathy, acidosis, and hypothermia), and resuscitated with FFP or FDP (n = 6/group; plasma volumes equal to the volume of shed blood). No treatment, and resuscitation with fresh whole blood served as the control groups (n = 6/group). Coagulation profiles (thromboelastography, PT, partial thromboplastin time, international normalized ratio, fibrinogen) were measured serially during the experiment, and for 4 hours posttreatment. Results: In vitro analysis revealed no differences in the coagulation profiles of FFP and FDP. The lyophilization process did not decrease the activity levels of the measured clotting factors. In the swine model, multiple injuries and hemorrhagic shock caused a 50% to 70% increase in PT (p = 0.03), and infusion of FDP and FFP were equally effective in correcting the coagulopathy. Conclusion: Plasma can be lyophilized and freeze-dried to create a logistically superior product without compromising its hemostatic properties. This product may be suitable for use in austere environments, such as a battlefield, for the treatment of trauma-associated coagulopathy. C1 [Alam, Hasan B.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, Boston, MA 02114 USA. [Shults, Christian] Washington Hosp Ctr, Washington, DC 20010 USA. [Fischer, Thomas H.] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA. [Schreiber, Martin A.; Tieu, Brandon] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Holcomb, John B.; Sondeen, Jill L.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Alam, HB (reprint author), Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Trauma Emergency Surg & Surg Crit Care, 165 Cambridge St,Suite 810, Boston, MA 02114 USA. EM hbalam@partners.org OI Tabbara, Malek/0000-0003-1046-7803 NR 44 TC 56 Z9 60 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2008 VL 65 IS 5 BP 975 EP 985 DI 10.1097/TA.0b013e3181801cd9 PG 11 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 372DD UT WOS:000260881000002 PM 19001961 ER PT J AU Black, IH Angelucci, MP Linfoot, JA Grathwohl, KW AF Black, Ian H. Angelucci, Michael P. Linfoot, John A. Grathwohl, Kurt W. TI Novel Use of a Portable Ventilation Device With Low-Flow Tracheal Insufflation of Oxygen in a Swine Model SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Tracheal insufflation of oxygen; Apneic oxygenation; Portable ventilators; Military medicine; Oxygen conservation ID BAG-VALVE DEVICE; DRIVEN RESUSCITATORS; 1ST RESPONDERS; TRIAL AB Introduction: Mechanical ventilation of intubated patients is standard to meet oxygenation and ventilation goals. This can require significant energy and oxygen resources. In military operations and mass casualty disasters, oxygen conserving strategies may be important. Low now tracheal insufflation of oxygen (TRIO). is a technique that provides adequate oxygenation while conserving oxygen during apnea. This technique, however. is limited by increases in carbon dioxide (CO2) when used for extended periods. The addition of passive pressure release ventilation could potentially improve CO, elimination and the acceptance of this technique. The purpose of this study was to determine whether TRIO combined with the novel configuration of a portable ventilator used to provide passive pressure release ventilation improves CO2 levels during apneic oxygenation. Methods: Animals (n = 7) were anesthetized, paralyzed, and intubated. Oxygen (O-2) was insufflated through the capillary lumen of the Boussignac endotracheal tube at 2 L/min. The low flow O-2 was the only source of power and gas for ventilation. A modified Oxylator EMX transport ventilator connected to the endotracheal tube was configured to release when pressure in the subjects lungs reached 30 cm H2O. No electrical or pneumatic sources were required. Hemodynamic measurements and arterial blood gases were taken at various intervals for 2 hours. Results: All pigs remained adequately oxygenated with Pao(2) >390 mm Hg in all subjects at every blood gas measurement and survived the 2-hour experiment. Baseline Paco(2) (43 +/- 4 mm Hg) increased and pH (7.48 +/- 0.03) decreased to 72 +/- 5 mm Hg and 7.29 +/- 0.02 at 1 hour and 83 +/- 8, 7.24 +/- 0.03 at 2 hours. This is significantly less than would be expected during apnea over this time period. Hemodynamic measurements remained stable. Conclusion: The combination of low flow TRIO with a modified Oxylator in this novel configuration provides acceptable Pao(2), Paco(2), and hemodynamic parameters for 2 hours in apneic swine. This could be a valuable technique in situations where oxygen and power are limited. C1 [Black, Ian H.] Brooke Army Med Ctr, Dept Anesthesiol & Operat Serv, Ft Sam Houston, TX 78234 USA. [Linfoot, John A.] San Antonio Uniformed Serv Hlth Educ, San Antonio, TX USA. RP Black, IH (reprint author), Brooke Army Med Ctr, Dept Anesthesiol & Operat Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM ian.h.black@us.army.mil NR 10 TC 1 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD NOV PY 2008 VL 65 IS 5 BP 1133 EP 1139 DI 10.1097/TA.0b013e318166d262 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 372DD UT WOS:000260881000027 PM 19001987 ER PT J AU Whitman, EJ Groskopf, J Ali, A Chen, YM Blase, A Furusato, B Petrovics, G Ibrahim, M Elsamanoudi, S Cullen, J Sesterhenn, IA Brassell, S Rittenhouse, H Srivastava, S McLeod, DG AF Whitman, Eric J. Groskopf, Jack Ali, Amina Chen, Yongmei Blase, Amy Furusato, Bungo Petrovics, Gyorgy Ibrahim, Mona Elsamanoudi, Sally Cullen, Jennifer Sesterhenn, Isabell A. Brassell, Stephen Rittenhouse, Harry Srivastava, Shiv McLeod, David G. TI PCA3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volume SO JOURNAL OF UROLOGY LA English DT Article DE prostate; prostatic neoplasms; urine; tumor marker, biological; gene expression ID MOLECULAR URINE ASSAY; ACTIVE SURVEILLANCE; CANCER; BIOPSY; NOMOGRAM; MEN; DIAGNOSIS; SURVIVAL; LEVEL AB Purpose: PCA3 is a prostate specific, nonprotein coding RNA that is over expressed in prostate cancer. Recent studies showed the diagnostic potential of a urine based PCA3 for predicting biopsy outcome. We assessed the relationship between urine PCA3 and pathological features in whole mount radical prostatectomy specimens. Materials and Methods: Post-digital rectal examination urine specimens were obtained from 72 men with prostate cancer before radical prostatectomy. PCA3 and PSA mRNA were measured. The ratio of PCA3 to PSA mRNA was recorded as a PCA3 score and correlated with data on each prostate specimen. Results: Patients with extracapsular extension had a significantly higher median PCA3 score than patients without extracapsular extension (48.8 vs 18.7, p = 0.02). PCA3 score significantly correlated with total tumor volume (r = 0.38, p < 0.01). On multivariate analysis PCA3 score was an independent predictor of extracapsular extension (p = 0.01) and total tumor volume less than 0.5 cc (p = 0.04). At a cutoff PCA3.score of 47 extracapsular extension was predicted with 94% specificity and an 80% positive predictive value. When combined with serum PSA and biopsy Gleason score, the ROC AUC for predicting extracapsular extension was 0.90. Conclusions: PCA3 detected in the post-digital rectal examination urine of patients with prostate cancer correlated with pathological findings. Therefore, it could provide prognostic information. To our knowledge this is the first report of a molecular urine assay that predicts extracapsular extension. C1 [McLeod, David G.] Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Furusato, Bungo; Sesterhenn, Isabell A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Whitman, Eric J.; Ali, Amina; Chen, Yongmei; Furusato, Bungo; Petrovics, Gyorgy; Ibrahim, Mona; Elsamanoudi, Sally; Cullen, Jennifer; Srivastava, Shiv; McLeod, David G.] Ctr Prostate Dis Res, Bethesda, MD USA. [Petrovics, Gyorgy; Brassell, Stephen; Srivastava, Shiv; McLeod, David G.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD USA. Gen Probe Inc, San Diego, CA USA. RP McLeod, DG (reprint author), Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Dept Surg, Urol Serv, Washington, DC 20307 USA. EM david.mcleod@amedd.army.mil OI Furusato, Bungo/0000-0003-4614-9882 FU Gen-Probe, Inc. FX Supported by a grant from Gen-Probe, Inc., San Diego, California (DGM, SS). NR 20 TC 106 Z9 111 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 2008 VL 180 IS 5 BP 1975 EP 1978 DI 10.1016/j.juro.2008.07.060 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 361BH UT WOS:000260102000030 PM 18801539 ER PT J AU Dhawan, A Muth, JF Leonard, DN Gerhold, MD Gleeson, J Vo-Dinh, T Russell, PE AF Dhawan, A. Muth, J. F. Leonard, D. N. Gerhold, M. D. Gleeson, J. Vo-Dinh, T. Russell, P. E. TI Focused in beam fabrication of metallic nanostructures on end faces of optical fibers for chemical sensing applications SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 52nd International Conference on Electron, Ion and Photon Beam Technology and Nanofabrication CY MAY 27-30, 2008 CL Portland, OR DE chemical sensors; fibre optic sensors; focused ion beam technology; gold; metallic thin films; nanostructured materials; refractive index; silver; surface plasmon resonance ID HOLE ARRAYS; PLASMON; NANOPARTICLES AB Focused ion beam (FIB) fabrication of fiber optic sensors, mainly chemical sensors, which are based on plasmonics-active nanostructures formed on the cleaved tips of optical fibers, is reported. The nanostructures fabricated included nanoholes in optically thick metallic films as well as metallic nanopillars and nanorods. The sensing mechanism is based on detecting shifts in surface plasmon resonances (SPRs) associated with nanoholes in metallic films and localized SPRs of metallic nanopillars and nanorods, when the refractive index of the medium surrounding the nanostructures is changed. These sensors can be employed for the detection of chemical agents in air as well as liquid media surrounding the sensors. FIB milling was employed to fabricate ordered arrays of nanoholes in optically thick (100-240 nm) metallic films deposited on cleaved end faces of multimode, four-mode, and single-mode optical fibers. Separately, metallic nanorods and nanopillars were formed by first depositing a metallic (gold or silver) film on tips of optical fibers, which was followed by FIB milling large area patterns to form freestanding nanorods and nanopillars. Utilizing FIB allows engineering nanostructure geometries, i.e., nanostructure shapes and sizes that are chosen based on the plasmon resonances associated with them. Formation of periodic arrays of nanoholes provides a means of tuning plasmon resonance peaks, associated with extraordinary transmission of light through the array of nanoholes in the metallic films, based on periodicity and shape of the nanoholes as well as on refractive index changes to form sensitive chemical sensors. C1 [Dhawan, A.; Gerhold, M. D.] USA, Res Off, Durham, NC 27709 USA. [Dhawan, A.; Vo-Dinh, T.] Duke Univ, Fitzpatrick Inst Photon, Durham, NC 27708 USA. [Muth, J. F.] N Carolina State Univ, Raleigh, NC 27695 USA. [Leonard, D. N.; Gleeson, J.; Russell, P. E.] Appalachian State Univ, Boone, NC 28608 USA. RP Dhawan, A (reprint author), USA, Res Off, Durham, NC 27709 USA. EM russllp@appstate.edu RI Muth, John/E-9027-2012 OI Muth, John/0000-0002-2488-7721 FU NIBIB NIH HHS [R01 EB006201, R01 EB006201-04]; NIEHS NIH HHS [R01 ES014774] NR 14 TC 30 Z9 32 U1 0 U2 17 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2008 VL 26 IS 6 BP 2168 EP 2173 DI 10.1116/1.3013329 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 379GV UT WOS:000261385600062 PM 23976838 ER PT J AU Morris, CJ Dubey, M AF Morris, Christopher J. Dubey, Madan TI Microscale self-assembly using molten alloys with different melting points SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 52nd International Conference on Electron, Ion and Photon Beam Technology and Nanofabrication CY MAY 27-30, 2008 CL Portland, OR DE bismuth alloys; contact resistance; electrical contacts; integrated circuit interconnections; integrated circuit packaging; lead alloys; liquid metals; melting point; reflow soldering; self-assembly; tin alloys ID HETEROGENEOUS INTEGRATION AB The authors demonstrate a system for self-assembling 280 mu m sized parts onto a separate template using two molten alloys having differing melting points. The use of two alloys decoupled the formation of mechanical and electrical connections and improved the resulting electrical contact resistance by over two orders of magnitude. C1 [Morris, Christopher J.; Dubey, Madan] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE RL, Adelphi, MD 20783 USA. RP Morris, CJ (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE RL, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM christopher.morris17@arl.army.mil NR 18 TC 2 Z9 2 U1 0 U2 6 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD NOV PY 2008 VL 26 IS 6 BP 2534 EP 2538 DI 10.1116/1.2978395 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 379GV UT WOS:000261385600132 ER PT J AU Aitichou, M Saleh, S Kyusung, P Huggins, J O'Guinn, M Jahrling, P Ibrahim, S AF Aitichou, Mohamed Saleh, Sharron Kyusung, Park Huggins, John O'Guinn, Monica Jahrling, Peter Ibrahim, Sofi TI Dual-probe real-time PCR assay for detection of variola or other orthopoxviruses with dried reagents SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE Orthopox virus; Smallpox; Variola; Monkeypox; Cowpox; Vaccinia; Taqman; PCR; Real-time PCR; Multiplex PCR; Dried PCR reagents ID SMALLPOX-VIRUS; ROCHE LIGHTCYCLER; MONKEYPOX; IDENTIFICATION; DNA; COWPOX AB A real-time, multiplexed polymerase chain reaction (PCR) assay based on dried PCR reagents was developed. Only variola virus could be specifically detected by a FAM (6-carboxyfluorescein)-labeled probe while camelpox, cowpox, monkeypox and vaccinia viruses could be detected by a TET (6-carboxytetramethylrhodamine)-labeled probe in a single PCR reaction. Approximately 25 copies of cloned variola virus DNA and 50 copies of genomic orthopoxviruses DNA could be detected with high reproducibility. The assay exhibited a dynamic range of seven orders of magnitude with a correlation coefficient value greater than 0.97. The sensitivity and specificity of the assay, as determined from 100 samples that contained nucleic acids from a multitude of bacterial and viral species were 96% and 98%, respectively. The limit of detection, sensitivity and specificity of the assay were comparable to standard real-time PCR assays with wet reagents. Employing a multiplexed format in this assay allows simultaneous discrimination of the variola virus from other closely related orthopoxviruses. Furthermore, the implementation of dried reagents in real-time PCR assays is an important step towards simplifying such assays and allowing their use in areas where cold storage is not easily accessible. (C) 2008 Elsevier B.V. All rights reserved. C1 [Aitichou, Mohamed; Saleh, Sharron; Huggins, John; O'Guinn, Monica; Ibrahim, Sofi] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. [Jahrling, Peter] NIAID, NIH, Bethesda, MD 20892 USA. [Kyusung, Park] Invitrogen Corp, Carlsbad, CA USA. RP Aitichou, M (reprint author), USA, Med Res Inst Infect Dis, Div Virol, 1425 Porter St,Ft Frederick, Frederick, MD 21702 USA. EM mohamed.aitichou@amedd.army.mil FU Defense Threat Reduction Agency [02-4-41-091] FX This work was supported by research program funds managed by the Defense Threat Reduction Agency grant #02-4-41-091. We thank Katheryn Kenyon for reviewing the manuscript. The mention of materials or products in this article does not constitute endorsement by the Department of Defense or the United States government. NR 28 TC 8 Z9 10 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD NOV PY 2008 VL 153 IS 2 BP 190 EP 195 DI 10.1016/j.jviromet.2008.07.018 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 367PV UT WOS:000260565200017 PM 18725245 ER PT J AU Gardner, CL Burke, CW Tesfay, MZ Glass, PJ Klimstra, WB Ryman, KD AF Gardner, Christina L. Burke, Crystal W. Tesfay, Mulu Z. Glass, Pamela J. Klimstra, William B. Ryman, Kate D. TI Eastern and Venezuelan Equine Encephalitis Viruses Differ in Their Ability To Infect Dendritic Cells and Macrophages: Impact of Altered Cell Tropism on Pathogenesis SO JOURNAL OF VIROLOGY LA English DT Article ID SINDBIS-VIRUS; ALPHAVIRUS REPLICATION; ALPHA/BETA-INTERFERON; HEPARAN-SULFATE; CAPSID PROTEIN; MESSENGER-RNA; E2 GLYCOPROTEIN; GENE-EXPRESSION; INDUCED DISEASE; IN-VITRO AB Eastern and Venezuelan equine encephalitis viruses (EEEV and VEEV, respectively) cause severe morbidity and mortality in equines and humans. Like other mosquito-borne viruses, VEEV infects dendritic cells (DCs) and macrophages in lymphoid tissues, fueling a serum viremia and facilitating neuroinvasion. In contrast, EEEV replicates poorly in lymphoid tissues, preferentially infecting osteoblasts. Here, we demonstrate that infectivity of EEEV for myeloid lineage cells including DCs and macrophages was dramatically reduced compared to that of VEEV, whereas both viruses replicated efficiently in mesenchymal lineage cells such as osteoblasts and fibroblasts. We determined that EEEV infection of myeloid lineage cells was restricted after attachment, entry, and uncoating of the genome. Using replicon particles and translation reporter RNAs, we found that translation of incoming EEEV genomes was almost completely inhibited in myeloid, but not mesenchymal, lineage cells. Alpha/beta interferon (IFN-alpha/beta) responses did not mediate the restriction, as infectivity was not restored in the absence of double-stranded RNA-dependent protein kinase, RNase L, or IFN-alpha/beta receptor-mediated signaling. We confirmed these observations in vivo, demonstrating that EEEV is compromised in its ability to replicate within lymphoid tissues, whereas VEEV does so efficiently. The altered tropism of EEEV correlated with an almost complete avoidance of serum IFN-alpha/beta induction in vivo, which may allow EEEV to evade the host's innate immune responses and thereby enhance neurovirulence. Taken together, our data indicate that inhibition of genome translation restricts EEEV infectivity for myeloid but not mesenchymal lineage cells in vitro and in vivo. In this regard, the tropisms of EEEV and VEEV differ dramatically, likely contributing to observed differences in disease etiology. C1 [Gardner, Christina L.; Burke, Crystal W.; Tesfay, Mulu Z.; Klimstra, William B.; Ryman, Kate D.] Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, Shreveport, LA 71130 USA. [Gardner, Christina L.; Burke, Crystal W.; Tesfay, Mulu Z.; Klimstra, William B.; Ryman, Kate D.] Louisiana State Univ, Hlth Sci Ctr, Ctr Mol & Tumor Virol, Shreveport, LA 71130 USA. [Glass, Pamela J.] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21701 USA. RP Ryman, KD (reprint author), Louisiana State Univ, Hlth Sci Ctr, Dept Microbiol & Immunol, 2-347B Med Sch Bldg B,1501 Kings Highway, Shreveport, LA 71130 USA. EM kryman@lsuhsc.edu RI Glass, Pamela/G-1170-2011 FU National Institutes of Health [R21 AI069158]; NIAID/NIH [U54 AI057156] FX We thank Michael Farmer, Danielle Gonzalez, and DeAquanita McKinney for excellent technical assistance and Tracee Terry in the LSUHSC-S Research Core Facility for performing in vivo imaging studies. We thank Michael Parker for critical reading of the manuscript and Gerard Karsenty's group for providing protocols for the generation of primary murine osteoblast cultures. We are particularly indebted to Scott Weaver and Robert Johnston for providing us with cDNA clones for generating viruses and replicons.; This work was supported by National Institutes of Health grant R21 AI069158 ( K. D. R.) and grants from NIAID/NIH through the Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research (WRCE) U54 AI057156 (Career Development award to K. D. R. and major project subcontract to W. B. K.). NR 57 TC 53 Z9 53 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 2008 VL 82 IS 21 BP 10634 EP 10646 DI 10.1128/JVI.01323-08 PG 13 WC Virology SC Virology GA 361EF UT WOS:000260109600031 PM 18768986 ER PT J AU Montain, SJ Baker-Fulco, CJ Niro, PJ Reinert, AR Cuddy, JS Ruby, BC AF Montain, Scott J. Baker-Fulco, Carol J. Niro, Philip J. Reinert, Andrew R. Cuddy, John S. Ruby, Brent C. TI Efficacy of Eat-on-Move Ration for Sustaining Physical Activity, Reaction Time, and Mood SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE CAFFEINE; DIET; MEAL FREQUENCY; SNACKING; ACTIMETRY; PERFORMANCE ID CAFFEINE MAINTAINS VIGILANCE; ENERGY-EXPENDITURE; COGNITIVE PERFORMANCE; WILDFIRE SUPPRESSION; OPERATIONS; INGESTION; SUPPLEMENTATION; PRODUCTIVITY; EXERCISE; LABORERS AB MONTAIN, S. J., C. J. BAKER-FULCO, P. J. NIRO, A. R. REINERT, J. S. CUDDY, and B. C. RUBY. Efficacy of Eat-on-Move Ration for Sustaining Physical Activity, Reaction Time, and Mood. Med. Sci. Sports Exerc., Vol. 40, No. 11, pp. 1970-1976, 2008. Repeated carbohydrate feedings and caffeine have been shown to increase self-paced physical activity. Whether a field ration pack that promotes snacking of these items would enhance physical activity remains unclear. Purpose: Evaluate the effectiveness of a ration pack consisting of eat-on-move items to promote snacking, as well as caffeine items, as a nutritional strategy to improve performance. Methods: Twenty-eight wildland firefighters consumed both an eat-on-move ration (first strike ration (FSR): 13.2 MJ. 420 g CHO, 665 mg caffeine daily) and entree-based ration (meals, ready-to-eat (MRE): 11.9 MJ, 373 g CHO, 100 mg caffeine daily) for 2 d separated by I d. Diet order was counterbalanced. Outcome measurements included self-paced physical activity determined by actimetry, reaction time, number of eating occasions using dietary recall, and dietary intake from food wrapper collection. Results: Total eating episodes were higher with FSR compared with MRE (P = 0.013; mean +/- SD: 8.2 +/- 1.3 vs 7.6 +/- 1.1 episodes.2 d(-1)), as were 2-d energy intake (22.0 +/- 2.4 vs 18.4 +/- 2.5 MJ; P < 0.01), carbohydrate intake (698 76 vs 546 82 mg P < 0.01), self-reported caffeine intake (347 262 vs 55 65 mg P < 0.01). and average end-shift salivary caffeine (1.6 +/- 1.9 vs 0.7 +/- 1.0 mu g.mL(-1); P < 0.01). Total activity counts were higher (P = 0.046) when consuming FSR (507,833 +/- 129,130 counts per shift) compared with MRE (443,095 +/- 142,208 counts per shift). This was accomplished by spending a greater percentage of work shift with activity counts >1000 counts.min(-1) (21 +/- 8% vs 18 +/- 6%; P = 0.01) and less percent of work shift <50 counts.min(-1) (33 +/- 10% vs 38 +/- 10%; P = 0.01). Conclusions: Delivery of energy and caffeine in a manner that promotes snacking behavior is advantageous for increasing self-selected physical activity during arduous labor. C1 [Montain, Scott J.; Baker-Fulco, Carol J.; Niro, Philip J.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Reinert, Andrew R.; Cuddy, John S.; Ruby, Brent C.] Univ Montana, Dept Hlth & Human Performance, Missoula, MT USA. RP Montain, SJ (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Bldg 42,Kansas St, Natick, MA 01760 USA. EM scott.montain@us.army.mil RI Cuddy, John/A-6728-2009; WPEM, Montana/A-6754-2009 FU US Army FX The authors acknowledge the technical support of Susan McGraw, Jennifer Rood, Harris Lieberman, Joseph Domitrovich, and Nobuo Yasuda, as well as the efforts of the volunteers who participated in the study. Thanks are also extended to the fire overhead management teams for their cooperation with logistic support and access to the fire camp and crews. Funding was provided by the US Army.; Disclaimer: The views, opinions, and/or findings contained in this publication are those of the authors and should not be construed as an official Department of the Army position, policy, or decision unless so designated by other documentation. The results do not constitute endorsement by the American College of Sports Medicine. This paper is approved for public release; distribution is unlimited. NR 27 TC 15 Z9 15 U1 1 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 BP 1970 EP 1976 DI 10.1249/MSS.0b013e31817f4d58 PG 7 WC Sport Sciences SC Sport Sciences GA 365VA UT WOS:000260435800014 PM 18845969 ER PT J AU Evans, RK Antczak, AJ Lester, M Yanovich, R Israeli, EA Moran, DS AF Evans, Rachel K. Antczak, Amanda J. Lester, Mark Yanovich, Ran Israeli, Er-An Moran, Daniel S. TI Effects of a 4-Month Recruit Training Program on Markers of Bone Metabolism SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE BIOMARKER; BONE METABOLISM; TRAINING; GENDER; BONE TURNOVER ID VITAMIN-D STATUS; STRESS-FRACTURES; GENDER-DIFFERENCES; PHYSICAL-ACTIVITY; BIOCHEMICAL MARKERS; PARATHYROID-HORMONE; MILITARY RECRUITS; FEMORAL-NECK; YOUNG-WOMEN; TURNOVER AB EVANS, R. K., A. J. ANTCZAK, M. LESTER, R. YANOVICH, E. ISRAELI, and D. S. MORAN. Effects of a 4-Month Recruit Training Program on Markers of Bone Metabolism. Med. Sci. Sports Exerc., Vol. 40 No. I I S, pp. S660-S670. 2008. Stress fracture susceptibility results front accelerated bone remodeling after onset of novel exercise and may be reflected in bone turnover changes, It is unknown if the bone turnover response to exercise is different between sexes. Purpose: To assess disparity between sexes in boric metabolism markers during military recruit training and to evaluate relationships between bone turnover markets and factors that may affect boric metabolism. Methods: Volunteers were age-matched men (n = 58) and women (n = 199) 19 yr old, entering gender-integrated combat training. Blood was collected at 0, 2, and 4 months and anthropometric and fitness measures at 0 and 4 months. Serum was analyzed for biomarkers reflecting bone formation (bone alkaline phosphatase and procollagen 1 N-terminal peptide), bone resorption (C-telopeptide cross-links of type I collagen and tartrate-resistant acid phosphatase). endocrine regulation (parathyroid hormone, calcium. and 25(OH)D), and inflammation (interleukin 1B. interleukin 6, and tumor necrosis tactor alpha). Data were analyzed rising ANOVA, Correlation, and regression analyses. Results: Bone turnover Markers were higher in men (P < 0.01) and increased similarly for both sexes front 0 to 2 months (P < 0.01). Independent of gender, VO2max (R-2 = 0.477) and scrum calcium (R-2 = 0.252) predicted bone formation activity (bone alkaline phosphatase) at baseline (P < 0.01). Scrum calcium and parathyroid hormone decreased (2.0 and 6.4%, respectively) front 0 to 2 months (P < 0.001), returning to baseline at 4 months for both sexes. Men exhibited a decrease in 25(OH)D front 0 to 4 months (P = 0.007). Changes in endocrine regulators were significantly correlated with changes in boric turnover markers. Inflammatory markers did not differ between sexes and (It(] not increase. Conclusion: Military training increased boric formation and resorption markers in 2 Months, Suggesting rapid onset of strenuous exercise accelerates bone turnover similarly in men and,women. Although boric turnover markers were higher in men than women, bone formation status may be related to aerobic fitness and serum calcium independent of gender and may be affected by small changes in endocrine regulators related to nutrition. C1 [Evans, Rachel K.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Yanovich, Ran; Israeli, Er-An; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. RP Evans, RK (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Bldg 42,Kansas Street, Natick, MA 01760 USA. EM rachel.evans@us.army.mil NR 43 TC 37 Z9 38 U1 2 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S660 EP S670 DI 10.1249/MSS.0b013e318189422b PG 11 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900009 PM 18849868 ER PT J AU Evans, RK Negus, C Antczak, AJ Yanovich, R Israeli, E Moran, DS AF Evans, Rachel K. Negus, Charles Antczak, Amanda J. Yanovich, Ran Israeli, Eran Moran, Daniel S. TI Sex Differences in Parameters of Bone Strength in New Recruits: Beyond Bone Density SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE pQCT; IMAGE ANALYSIS METHODOLOGY; BONE GEOMETRY; BASIC TRAINING; STRESS FRACTURE ID STRESS-FRACTURES; MINERAL DENSITY; GENDER-DIFFERENCES; CORTICAL BONE; LONG BONES; BODY-SIZE; IN-VITRO; MORPHOLOGY; ABSORPTIOMETRY; MICRODAMAGE AB EVANS, R. K. C. NEGUS, A. J. ANTCZAK, R. YANOVICH, E. ISRAELI, and D. S. MORAN. Sex Differences in Parameters of Bone Strength in New Recruits: Beyond Bone Density. Med. Sci. Sports Exerc., Vol. 40, No. I I S, pp. S645-S653 2008. Background: Stress fracture (SF) injuries in new recruits have long been attributed to low bone mineral density (BMD). Low areal BMD assessed using two-dimensional dual-energy x-ray absorptiometry imaging, however, reflects structural density and is affected by smaller measures of bone geometry. Recent studies support a relationship between bone size and SF and indicate that slender bones are more susceptible to damage under identical loading conditions. Peripheral quantitative computed tomography (pQCT) is a three-dimensional imaging tool that provides measures of tissue density and geometry parameters of the tibia, a common site of SF. Purpose: To evaluate sex differences in parameters of volumetric BMD (vBMD), geometry, and strength of the tibia in new recruits using a novel pQCT image analysis procedure. Methods: pQCT images were obtained from 128 healthy men and women (20 male, 108 female, aged 18-21 yr) entering a 4-month gender-integrated combat training program in the Israeli Defense Forces. Tibial scans taken at sites 4% (trabecular bone), 38%, and 66% (cortical bone) from the distal end plate were analyzed using MATLAB to assess whole-bone and regional parameters. Measures included vBMD, geometry (diameter, area, cortical thickness, and canal radius), and strength (moments of inertia and bone strength and slenderness indices), Results: With the exception of normalized canal radius, which did not differ between sexes, all measures of bone geometry (P < 0.0001) and strength (P < 0,000 1 to P = 0.07) were greater in men. Women exhibited 2.7% to 3.0% greater cortical vBMD than men, whereas trabecular vBMD was 8.4% lower in women (P < 0.001). These differences remained significant after adjusting for body size. Conclusion: Sex differences in bone geometry and mineralization of the tibia may contribute to a decreased ability to withstand the demands imposed by novel, repetitive exercise in untrained individuals entering recruit training. C1 [Evans, Rachel K.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Negus, Charles] L3 Jaycor, San Diego, CA USA. [Yanovich, Ran; Israeli, Eran; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. RP Evans, RK (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Bldg 42,Kansas St, Natick, MA 01760 USA. EM rachel.evans@us.army.mil RI CHEN, Jiangang/A-1549-2011 NR 28 TC 23 Z9 24 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S645 EP S653 DI 10.1249/MSS.0b013e3181893cb7 PG 9 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900007 PM 18849870 ER PT J AU Finestone, A Milgrom, C Evans, R Yanovich, R Constantin, N Moran, DS AF Finestone, Aharon Milgrom, Charles Evans, Rachel Yanovich, Ran Constantin, Naama Moran, Daniel S. TI Overuse Injuries in Female Infantry Recruits during Low-Intensity Basic Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE STRESS FRACTURE; GENDER; MILITARY; BMI; RISK; FACTOR; MUSCULOSKELETAL ID STRESS-FRACTURES; RISK-FACTORS; MILITARY RECRUITS; WOMEN; MEN AB FINESTONE. A., C. MILGROM, R. EVANS. R. YANOVICH, N. CONSTANTINI. and D. S. MORAN. Overuse Injuries in Female Infantry Recruits during Low-Intensity Basic Training. Med. Sci. Sports Exerc.. Vol. 40, No. I IS. pp. S630-S635, 2008. Purpose: The purpose of this prospective study was to investigate the epidemiology of overuse injuries and to identify common risk factors for stress fractures among female and male recruits in a new light infantry basic training designed to minimize the incidence of overuse injuries. Methods: Study subjects were male and female recruits in the 16-wk light infantry basic training. A control group of noncombat fernale medics whose military service did not include demanding physical activities was recruited to assess the female recruits' preinduction physical preparedness. Pretraining survey of all participants' medical and sports participation histories was conducted. Anthropometric measurements were performed. Subjects were followed every 3 wk for overuse injuries. Stress fractures were diagnosed by radiography or scintigraphy. Results: Ninety-nine fernale recruits. 36 male recruits, and 55 controls participated. Although 31% of the controls reported regular preinduction sports participation, less than 25% of both male and female recruits did. Stress fractures incidence was 0% among males and controls but 12% among fernale recruits (P = 0.03). The mean body mass index officinale recruits with stress fractures was 19.2 +/- 2.6 versus 22.5 +/- 3.3 kg.m(-2) of female recruits without stress fractures (P = 0.02, odds ratio = 1.397, 95% confidence interval = 1.065-1.833). No statistically significant difference was found between female and male military trainees in the incidence of other overuse injuries, but there was a statistical trend (P = 0.07) for more back pain among females. Conclusions: Lower body mass index was the only variable identified as a risk factor for stress fractures among female recruits in the present study. It does not explain the markedly different response of female and male recruits' bones to the low demand training. There may be ail intrinsic difference between male and female bone resistance to fatigue. C1 [Milgrom, Charles; Constantin, Naama] Hadassah Hebrew Univ, Med Ctr, Dept Orthopaed Surg, Jerusalem, Israel. [Finestone, Aharon] Assaf Harofeh Med Ctr, Dept Orthopaed, Foot & Ankle Unit, Zerifin, Israel. [Evans, Rachel] USA, Environm Med Res Inst, Bone Hlth Res Program, Mil Performance Div, Natick, MA 01760 USA. [Yanovich, Ran; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Yanovich, Ran; Moran, Daniel S.] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel. RP Milgrom, C (reprint author), Hadassah Univ Hosp, Dept Orthopaed, POB 12000, IL-91120 Jerusalem, Israel. EM charles.migrom@ekmd.huji.ic.il NR 30 TC 20 Z9 21 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S630 EP S635 DI 10.1249/MSS.0b013c3181892ff9 PG 6 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900005 PM 18849872 ER PT J AU Friedl, KE Evans, RK Moran, DS AF Friedl, Karl E. Evans, Rachel K. Moran, Daniels S. TI Stress Fracture and Military Medical Readiness: Bridging Basic and Applied Research SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE BONE BIOLOGY; GROUND REACTION FORCES; MECHANOTRANSDUCTION; MILITARY PERSONNEL; TRAINING STUDIES; GENOMICS ID BONE-MINERAL DENSITY; GROWTH-FACTOR-I; VITAMIN-D SUPPLEMENTATION; QUANTITATIVE TRAIT LOCI; OSCILLATORY FLUID-FLOW; FEMALE NAVY RECRUITS; SMALL ANIMAL PET; YOUNG-WOMEN; OSTEOBLASTIC CELLS; PHYSICAL-ACTIVITY AB FRIEDL, K. E., R. K. EVANS, and D. S. MORAN. Stress Fracture and Military Medical Readiness: Bridging Basic and Applied Research. Med. Sci. Sports Everc., Vol. 40, No. I IS, pp. S609-S622, 2008. Purpose: Military recruits and distance runners share a special risk of stress fracture injury. Recent efforts by US and Israeli military-sponsored researchers have uncovered important mechanisms and practical low-cost interventions. This article summarizes key findings relevant to prevention of stress fracture, including simple strategies to identify and to mitigate risk. Methods: Published research supported through the Bone Health and Military Medical Readiness research program and related military bone research was analyzed for contributions to preventing stress fracture in military recruits and optimizing bone health. Results: Thousands of military recruits helped test hypotheses about predictors of risk, safer exercise regimens, and rest, nutrition, gait training, and technology interventions to reduce stress fracture risk. Concurrent cellular, animal, and human laboratory studies were used to systematically investigate mechanisms of mechanical forces acting on bone and interactions through muscle, hormonal and genetic influences, and metabolism. The iterative and sometimes simultaneous process of basic discovery and field testing produced new knowledge that will provide safer science-based physical training. Discussion: Human training studies evaluating effects on bone require special commitment from investigators and funders due to volunteer compliance and attrition challenges. The findings from multiple studies indicate that measures of bone elasticity, fragility, and geometry are as important as bone mineral density in predicting fracture risk, with applications for new measurement technologies. Risk may be reduced by high intakes of calcium, vitamin D, and possibly protein (e.g., milk products). Prostaglandin E2, insulin-like growth factor 1, and estrogens are important mediators of osteogenesis, indicating reasons to limit the use of certain drugs (e.g., ibuprofen), to avoid excessive food restriction, and to treat hypogonadism. Abnormal gait may be a correctable risk factor. Brief daily vibration may stimulate bone mineral accretion similar to weight-bearing exercise. Genetic factors contribute importantly to bone quality, affecting fracture Susceptibility and providing new insights into fracture healing and tissue reengineering. C1 [Friedl, Karl E.] TATRC, Ft Detrick, MD 21702 USA. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Moran, Daniels S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. RP Friedl, KE (reprint author), TATRC, Bldg 1054, Ft Detrick, MD 21702 USA. EM karl.friedl@us.army.mil NR 138 TC 17 Z9 18 U1 1 U2 9 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S609 EP S622 DI 10.1249/MSS.0013018189263 PG 14 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900003 PM 18849874 ER PT J AU Israeli, E Merkel, D Constantini, N Yanovich, R Evans, RK Shahar, D Moran, DS AF Israeli, Eran Merkel, Drorit Constantini, Naama Yanovich, Ran Evans, Rachel K. Shahar, Danit Moran, Daniel S. TI Iron Deficiency and the Role of Nutrition among Female Military Recruits SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE ANEMIA; FEMALE SOLDIERS; FOOD FREQUENCY QUESTIONNAIRE ID FOOD-FREQUENCY QUESTIONNAIRE; BLOOD-LOSS; ANEMIA; WOMEN; EXERCISE; DIET; POPULATIONS; PREVALENCE; HEPCIDIN; SPORTS AB ISRAELI, E., D. MERKEL, N. CONSTANTINI, R. YANOVICH, R. K. EVANS, D. SHAHAR, and D. S. MORAN. Iron Deficiency and the Role of Nutrition among Female Military Recruits. Med. Sci. Sports Exerc., Vol. 40, No. I IS, pp. S685-S690 2008, The impact of iron deficiency is considerable when enhanced physical fitness is required. Female military recruits represent a unique population faced with intense physical and cognitive demands. Purpose: To examine the prevalence of iron deficiency and the impact of dietary habits among female recruits in the Israel Defense Forces. Methods: Three hundred and forty-eight recruits completed the study (188 female combatants, 58 male combatants, and 92 noncombat females). Dietary intake was assessed using a Food Frequency Questionnaire. Blood samples were collected for complete blood cell count, iron indices, and vitamin B-12. The common definitions for anemia and iron store deficiency were used as follows: hemoglobin <12 g.dL(-1) for females and <14 g.dL(-1) for males; serum ferritin <12 mg.dL(-1). Results: The prevalence of iron deficiency and iron deficiency anemia was 29.8% and 12.8%, respectively, among female combatants. Similar data were found among noncombat females (27.2% and 17.4%, respectively) as compared with 5.2% and 0% among males. No significant difference in iron or total calorie intake was detected between subjects with iron deficiency (with or without anemia) when compared with subjects with normal iron status in the same study group. Plant sources constituted 85% of dietary iron source for females, in comparison to 73% for males. The contribution of red meat to the daily iron intake was 2% for females and 20% for males. Conclusions: A high prevalence of iron deficiency was found among female recruits. Coupled with the iron loss during menstruation, inadequate iron intake may have a permissive role for iron deficiency in female recruits and is an important issue facing females in the military. C1 [Israeli, Eran] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Gastroenterol, Div Med, IL-91120 Jerusalem, Israel. [Israeli, Eran] Chaim Sheba Med Ctr, Israel Def Forces Med Corps, IL-52621 Tel Hashomer, Israel. [Yanovich, Ran; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Constantini, Naama] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Orthoped, Jerusalem, Israel. [Evans, Rachel K.; Moran, Daniel S.] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Shahar, Danit] Ben Gurion Univ Negev, S Daniel Abraham Int Ctr Hlth & Nutr, IL-84105 Beer Sheva, Israel. RP Israeli, E (reprint author), Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Gastroenterol, Div Med, POB 12000, IL-91120 Jerusalem, Israel. EM eran-i@bezeqint.net RI Shahar, Danit/B-4280-2012 NR 26 TC 7 Z9 7 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S685 EP S690 DI 10.1249/MSS.0b013e31818946ae PG 6 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900012 PM 18849865 ER PT J AU Lieberman, HR Kellogg, MD Bathalon, GP AF Lieberman, Harris R. Kellogg, Mark D. Bathalon, Gaston P. TI Female Marine Recruit Training: Mood, Body Composition, and Biochemical Changes SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE MILITARY; DEPRESSION; FATIGUE; STRESS; CORTISOL; CHOLESTEROL ID PSYCHOLOGICAL ADJUSTMENT; EXERCISE; DEPRESSION; COGNITION; SYMPTOMS; CORTISOL; FITNESS; WOMEN AB LIEBERMAN, H. R., M. D. KELLOGG, and G. P. BATHALON. Female Marine Recruit Training: Mood, Body Composition, and Biochemical Changes. Med. Sci. Sports Exerc., Vol. 40, No. I IS, pp. S671-S676,2008. Purpose: The US Marine Corps (USMC) is an elite military organization, Marine recruit training (RT) is a physically and psychologically intense 13-wk-long course designed to transform civilians into Marines through shared hardship and arduous training. Our laboratory conducted a study of female recruits in USMC RT that assessed the nature and the extent of cognitive, nutritional, and physical changes that occur during this unique period of structured mental and physical training. Methods: During RT, mood state was assessed every 4 wk with a standardized questionnaire,, the POMS. Body composition was assessed with dual-energy x-ray absorptiometry every 4 wk, and blood samples were collected for assessing metabolic status at the start and at the completion of training. Results: At the beginning of RT, approximately I wk after arrival at the training facility, levels of several negative mood states assessed by the POMS, depression, anxiety, fatigue, anger, and confusion, were considerably higher than POMS norms for age-matched, female College Students. However, over the course of RT, these mood states gradually declined until, by the completion of training, they were substantially lower than college norms. Body composition changed dramatically, with muscle mass increasing by 2.5 +/- 0.2 kg on average and fat declining by 4.7 +/- 0.4 kg. There were also significant changes in several biochemical parameters associated with nutritional and physical status, particularly LDL cholesterol, free fatty acids, and cortisol. Other factors, such as total cholesterol, HDL. cholesterol, and glucose, were more stable. Conclusions: Over the course of USMC RT, mood and body composition improved Substantially and dramatically, all indication of the effectiveness of USMC RT for altering the physical and the cognitive status of trainees. C1 [Lieberman, Harris R.; Kellogg, Mark D.; Bathalon, Gaston P.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM harris.lieberman@amedd.army.mil NR 26 TC 9 Z9 10 U1 2 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S671 EP S676 DI 10.1249/MSS.0b013c31818943b3 PG 6 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900010 PM 18849867 ER PT J AU Merkel, D Moran, DS Yanovich, R Evans, RK Finestone, AS Constantini, N Israeli, E AF Merkel, Drorit Moran, Daniel S. Yanovich, Ran Evans, Rachel K. Finestone, Aharon S. Constantini, Naama Israeli, Eran TI The Association between Hematological and Inflammatory Factors and Stress Fractures among Female Military Recruits SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE IRON DEFICIENCY; BASIC TRAINING; FEMALE SOLDIERS; ANEMIA ID IRON-DEFICIENCY; ANEMIA; PREVALENCE; ADOLESCENTS; EXERCISE; BONE; INTERLEUKIN-6; PLASMA; ARMY AB MERKEL, D., D. S. MORAN, R. YANOVICH, R. K. EVANS, A. S. FINESTONE, N. CONSTANTINI, and E. ISRAELI. The Association between Hematological and Inflammatory Factors and Stress Fractures among Female Military Recruits. Med. Sci. Sports Exerc., Vol. 40, No. 11S, pp. S691-S697, 2008. Background: With the growing number of females accepted for combat-related military duties in the Israeli Defense Forces, their special needs should be addressed. Previous studies on females in combat training have found a high prevalence of iron deficiency at recruitment as well as an increased rate of stress fractures (SF) and overuse injuries during training when compared with males. The aim of this study was to assess the correlation between hematological and inflammatory variables and SF occurrence among military recruits during basic training. Methods: Three gender-integrated light infantry units were followed prospectively. Female recruits inducted for medic and dental assistants' courses were followed for comparison. Hemoglobin, iron, transferrin, ferritin, C-reactive protein, and interleukin-6 levels were measured for all participants at recruitment and at 2 and 4 months of training. SF were diagnosed radiographically or scintigraphically according to the Israeli Defense Forces protocol. Results: A total of 438 subjects were recruited (female combatants = 227, male combatants 83, noncombatant females = 128). At induction, 18% of female combatants had anemia compared with 8% of males and 19% of noncombatants. Iron deficiency was noted in 40%, 6%, and 38%, respectively. There were no clinically significant changes during training. Twelve percent of female combatants developed SF, whereas none occurred among male combatants or noncombatants. Subjects sustaining an SF had significantly lower levels of serum iron and iron saturation. Conclusions: A high incidence of anemia as well as iron deficiency was found in this young asymptomatic cohort, with no significant change during training. The lower level of iron in female combatants sustaining SF warrants further investigation. C1 [Merkel, Drorit] Tel Aviv Univ, Sackler Fac Med, Chaim Sheba Med Ctr, Dept Hematol, IL-69978 Tel Aviv, Israel. [Moran, Daniel S.; Yanovich, Ran] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Finestone, Aharon S.] Assaf Harofeh Med Ctr, Dept Orthopaed Surg, Zerrifin, Israel. [Constantini, Naama] Hadassah Hebrew Univ, Med Ctr, Dept Orthoped Surg, Jerusalem, Israel. [Israeli, Eran] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Gastroenterol, Div Med, Jerusalem, Israel. RP Merkel, D (reprint author), Chaim Sheba Med Ctr, Dept Hematol, IL-52621 Tel Hashomer, Israel. EM mdorit@hotmail.com OI Finestone, Aharon/0000-0003-1956-5557 NR 26 TC 9 Z9 9 U1 2 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S691 EP S697 DI 10.1249/MSS.0b013e318189560c PG 7 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900013 PM 18849864 ER PT J AU Moran, DS Israeli, E Evans, RK Yanovich, R Constantinp, N Shabshin, N Merkel, D Luria, O Erlich, T Laor, A Finestone, A AF Moran, Daniel S. Israeli, Eran Evans, Rachel K. Yanovich, Ran Constantinp, Naama Shabshin, Nogah Merkel, Drorit Luria, Orit Erlich, Tomer Laor, Arie Finestone, Aharon TI Prediction Model for Stress Fracture in Young Female Recruits during Basic Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE BONE; IMAGING; RISK FACTOR; MILITARY; GENDER ID MILITARY RECRUITS; LOWER-EXTREMITY; REGIONAL DIFFERENCES; BONE-SCINTIGRAPHY; RISK-FACTORS; MICRODAMAGE; INJURIES; MUSCLE AB MORAN, D. S.. E. ISRAELI, R. K. EVANS, R. YANOVICH, N. CONSTANTINI. N. SHABSHIN. D. MERKEL, O. LURIA. T. ERLICH, A. LAOR, and A. FINESTONE. Prediction Model for Stress Fracture in Young Female Recruits during Basic Training. Med. Sci. Sports Exerc., Vol. 40, No. I I S, pp. S636-S644. 2008. Purpose: To develop a new prediction model for stress fractures (SF) in female recruits during basic training (BT) to identify risk factors and to try to prevent orthopedic injuries. Methods: Measurements and data collection were taken from three companies of gender-integrated recruited Units before the BT program (a total of 227 females and 83 males). Measurements included anthropometric variables, blood samples for hematology profile and markets for bone metabolism, fitness tests. bone quality (peripheral quantitative computed tomography). nutritional and activity habits. psychological assessment, and medical evaluation. SF were diagnosed during BT by bone scintigraphy and/or magnetic resonance imaging. Results: All collected measurements were Used to construct a new prediction model for the 27 and 192 female soldiers found with and without stress fracture, respectively. There were no SF in the male soldiers. The model successfully predicts 76.5% of the female soldiers with and without stress fractures (SF) as follows: PSF = -13.98 + 0.079 Ht - 0.014 Fe + 0.464 BUR - 0.105 BMI + 0.035 Ferritin, where PSF is the SF prediction according to the log odds(SF); odds(SF) is the ratio between probability of SF existence and nonexistence: Ht is the height (cm): BUR is a subjective assessment of burnout on a scale of 1 to 7: Fe is the iron blood level (mu gdL(-1)): ferritin is the iron storage level (ng.mL(-1)),: and BMI is the body mass index (kg.m(-2)). Conclusion: A young female recruited to all integrated light combat Unit is at risk for stress fracture if she is tall, lean, feels "burnout." has iron deficiency, and is at the high end of the normal ferritin range. However, futher evaluation is required in different populations, conditions, and training programs to evaluate these results. C1 [Moran, Daniel S.; Yanovich, Ran; Erlich, Tomer; Laor, Arie] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Moran, Daniel S.; Yanovich, Ran; Merkel, Drorit; Erlich, Tomer; Laor, Arie] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel. [Israeli, Eran] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Gastroenterol, Div Med, Jerusalem, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Constantinp, Naama] Hadassah Hebrew Univ, Med Ctr, Dept Orthopaed Surg, Jerusalem, Israel. [Shabshin, Nogah] Chaim Sheba Med Ctr, Dept Diagnost Imaging, IL-52621 Tel Hashomer, Israel. [Merkel, Drorit] Chaim Sheba Med Ctr, Dept Hematol, IL-52621 Tel Hashomer, Israel. [Luria, Orit] IAF, Tel Hashomer, Israel. [Finestone, Aharon] Assaf Harofeh Med Ctr, Dept Orthopaed, Foot & Ankle Unit, Zerifin, Israel. RP Moran, DS (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM dmoran@sheba.health.gov.il NR 36 TC 18 Z9 18 U1 0 U2 11 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S636 EP S644 DI 10.1249/MSS.0b013e31S1893164 PG 9 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900006 PM 18849871 ER PT J AU Schoomaker, EB AF Schoomaker, Eric B. TI Gender Factors Contributing to Performance and Musculoskeletal Injury in Military Recruits Introduction SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Editorial Material C1 USA, Med Command Off Surgeon Gen Falls Church, Falls Church, VA USA. RP Schoomaker, EB (reprint author), USA, Med Command Off Surgeon Gen Falls Church, Falls Church, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S607 EP S607 DI 10.1249/MSS.0b013e3181892b23 PG 1 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900001 PM 18849876 ER PT J AU Yanovich, R Evans, R Israeli, E Constantini, N Sharvit, N Merkel, D Epstein, Y Moran, DS AF Yanovich, Ran Evans, Rachel Israeli, Eran Constantini, Naama Sharvit, Nurit Merkel, Drorit Epstein, Yoram Moran, Daniel S. TI Differences in Physical Fitness of Male and Female Recruits in Gender-Integrated Army Basic Training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article; Proceedings Paper CT Shoresh and Biomedical Meeting 2006 CY OCT, 2006 CL ISRAEL DE MILITARY SERVICE; VO2max; GROUND REACTION FORCE PLATE; WINGATE ANAEROBIC TEST ID STRESS-FRACTURES; US ARMY; WOMEN; MEN; PROGRAM; EXERCISE; INJURIES; BODY; FAT AB YANOVICH. R., R. EVANS, E. ISRAELI, N. CONSTANTINI, N. SHARVIT. D. MERKEL. Y. EPSTEIN. and D. S. MORAN. Differences in Physical Fitness of Male and Female Recruits in Gender-Integrated Army Basic Training. Med. Sci. Sports Exerc., Vol. 40, No. 11S, pp. S654-S659, 2008. Purpose: To evaluate gender differences in physical fitness before and after a 4-month gender-integrated basic training (BT) course and to determine whether this program effectively narrowed the differences between male and female soldiers in physical fitness parameters. Methods: One hundred and thirty-seven soldiers (109 females and 28 males) successfully completed a 4-month BT course in the Israeli Defense Forces (IDF). The subject's physical fitness was evaluated pre- and post-BT by three laboratory tests [the maximal aerobic capacity the Leonardo Ground Reaction Force Plate, and the Wingate Anaerobic Test (WAnT)] and by the IDF physical fitness test (IDF-PT). Results: Females significantly improved their scores in the IDF-PT and laboratory aerobic tests, whereas males significantly improved only in the IDF-PT. After BT, gender differences narrowed by approximately 4% in all tests except tipper body strength. Although fitness improvement after BT was marginally higher in females than males, resulting in a slight narrowing of the gender differences, a significant gender gap in physical fitness still exists after BT. Conclusions: There was only a small overlap in physical abilities at the beginning of BT, which indicated vast differences in physical fitness between the genders. As expected, integrated combat BT improved physical fitness. Although females demonstrated marginally higher improvement in aerobic capacity. basic physiological gender differences were still evident at the end of the training regimen. C1 [Yanovich, Ran; Merkel, Drorit; Epstein, Yoram; Moran, Daniel S.] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. [Evans, Rachel] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Israeli, Eran] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Gastroenterol, Div Med, Jerusalem, Israel. [Constantini, Naama] Hadassah Hebrew Univ, Med Ctr, Dept Orthopaed Surg, Jerusalem, Israel. RP Yanovich, R (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM ranovich@sheba.health.gov.il NR 27 TC 8 Z9 8 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD NOV PY 2008 VL 40 IS 11 SU S BP S654 EP S659 DI 10.1249/MSS.0b013c3181893f30 PG 6 WC Sport Sciences SC Sport Sciences GA 365VB UT WOS:000260435900008 PM 18849869 ER PT J AU Ionin, B Hammamieh, R Shupp, JW Das, R Pontzer, CH Jett, M AF Ionin, Boris Hammamieh, Rasha Shupp, Jeffrey W. Das, Rina Pontzer, Carol H. Jett, Marti TI Staphylococcal enterotoxin B causes differential expression of Rnd3 and RhoA in renal proximal tubule epithelial cells while inducing actin stress fiber assembly and apoptosis SO MICROBIAL PATHOGENESIS LA English DT Article DE Renal proximal tubule epithelium; SEB; Toxic shock syndrome; RhoE; Rnd3; RhoA ID IN-VIVO; PROTEIN; SHOCK; RECEPTOR; TOXINS AB Staphylococcal enterotoxin B (SEB) is a toxic shock-inducing agent produced by Staphylococcus aureus. The hallmark of SEB-induced lethal shock is acute vasodilation leading to severe hypotension. Animal studies reveal that approximate to 70% of intravenously administered toxin localizes to renal proximal tubule epithelial cells (RPTEC). This evidence, together with the well-documented role of the kidney in regulation of vascular tone, suggests that molecular events induced in RPTEC by SEB may contribute to the blood pressure dysregulation seen in enterotoxic shock. In an attempt to elucidate these molecular mechanisms, differential display was performed on SEB-treated and untreated RPTEC, and 32 differentially expressed transcripts (DETs) were identified. One of the down-regulated DETs matched the sequence for Rnd3, which normally inhibits Rho protein function. Consistent with Rnd3 down-regulation, message for RhoA was shown to increase upon SEB exposure, and actin stress fiber formation was dramatically increased. Further, SEB-exposed cells showed both increased enzymatic activity of caspase-3 and an increase in the percentage of apoptotic cells. Taken together, these results support the hypothesis that RPTEC undergo apoptosis upon exposure to SEB. Furthermore, these data implicate the involvement of the Rho family proteins in the molecular signaling pathway induced by SEB in RPTEC. (C) 2008 Published by Elsevier Ltd. C1 [Ionin, Boris; Hammamieh, Rasha; Shupp, Jeffrey W.; Das, Rina; Jett, Marti] Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, Silver Spring, MD 20910 USA. [Pontzer, Carol H.] NIH, NCCAM, Bethesda, MD 20892 USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM martijett@us.army.mil NR 29 TC 9 Z9 10 U1 0 U2 3 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD NOV-DEC PY 2008 VL 45 IS 5-6 BP 303 EP 309 DI 10.1016/j.micpath.2008.07.002 PG 7 WC Immunology; Microbiology SC Immunology; Microbiology GA 397SG UT WOS:000262681800001 PM 18721871 ER PT J AU Eaton, KM Hoge, CW Messer, SC Whitt, AA Cabrera, OA McGurk, D Cox, A Castro, CA AF Eaton, Karen M. Hoge, Charles W. Messer, Stephen C. Whitt, Allison A. Cabrera, Oscar A. McGurk, Dennis Cox, Anthony Castro, Carl A. TI Prevalence of Mental Health Problems, Treatment Need, and Barriers to Care among Primary Care-Seeking Spouses of Military Service Members Involved in Iraq and Afghanistan Deployments SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 113th Annual Convention of the American-Psychological-Association CY AUG 18-21, 2005 CL Washington, DC SP Amer Psychol Assoc ID ARMY WIVES; PSYCHOLOGICAL WELL; FAMILY SEPARATION; STRESS; LIFE; DEPRESSION; VALIDITY; IMPACT; SATISFACTION; QUALITY AB Military spouses must contend with unique issues such as a mobile lifestyle, rules and regulations of military life, and frequent family separations including peacekeeping and combat deployments. These issues may have an adverse effect on the health of military spouses. This study examined the mental health status, rates of care utilization, source of care, as well as barriers and stigma of mental health care utilization among military spouses who were seeking care in military primary care clinics. The data show spouses have similar rates of mental health problems compared to soldiers. Spouses were more likely to seek care for their mental health problems and were less concerned with the stigma of mental health care than were soldiers. Services were most often received from primary care physicians, rather than specialty mental health professionals, which may relate to the lack of availability of mental health services for spouses on military installations. C1 [Eaton, Karen M.; Hoge, Charles W.; Whitt, Allison A.; Cox, Anthony] Walter Reed Army Inst Res, Div Psychiat & Behav Sci, Silver Spring, MD 20910 USA. [Messer, Stephen C.] Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. [Cabrera, Oscar A.; McGurk, Dennis] USA, Med Res Unit Europe, APO, AE 09042 USA. [Castro, Carl A.] USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. RP Eaton, KM (reprint author), Walter Reed Army Inst Res, Div Psychiat & Behav Sci, Robert Grant Ave, Silver Spring, MD 20910 USA. RI Messer, Stephen/B-6198-2012 OI Messer, Stephen/0000-0003-0503-9695 NR 35 TC 58 Z9 59 U1 3 U2 11 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2008 VL 173 IS 11 BP 1051 EP 1056 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 372UT UT WOS:000260928200001 PM 19055177 ER PT J AU Bishop, PA Crowder, TA Fielitz, LR Lindsay, TR Woods, AK AF Bishop, Phillip A. Crowder, Todd A. Fielitz, Lynn R. Lindsay, Timothy R. Woods, Amanda K. TI Impact of Body Weight on Performance of a Weight-Supported Motor Fitness Test in Men SO MILITARY MEDICINE LA English DT Article ID INFANTRY PERSONNEL; PHYSICAL-FITNESS; OBSTACLE COURSE AB The impact of body weight on test scores is a common issue in applied measurement. Dimensional analysis suggests that heavier participants are disadvantaged in weight-supported tasks. The purpose of this study was to evaluate the impact of body weight on performance scores for a military obstacle course. Three cohorts of male participants completed the Indoor Obstacle Course Test (IOCT). In cohort I (N = 2,191), height and weight were measured. In cohort 2 (N = 134), skinfold measurements were also performed. In cohort 3 (N = 44), all aforementioned measurements were performed, as well as upper- and lower-body tests for aerobic power, anaerobic power, muscular strength, and muscular endurance. The R-2 between IOCT scores and body weight was 0.06 and that between IOCT scores and percentage of body fat was 0.08. All cohort analyses suggested that, for male subjects, body weight had only a small impact on the performance score distribution and the IOCT is fit for purpose as a fair repeatable system for assessment of physical performance. C1 [Bishop, Phillip A.; Woods, Amanda K.] Univ Alabama, Dept Kinesiol, Tuscaloosa, AL 35487 USA. [Crowder, Todd A.; Fielitz, Lynn R.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. [Lindsay, Timothy R.] Univ Cape Town, Dept Human Biol, Res Unit Exercise Sci & Sports Med, ZA-7725 Newlands, South Africa. RP Bishop, PA (reprint author), Univ Alabama, Dept Kinesiol, Tuscaloosa, AL 35487 USA. NR 9 TC 2 Z9 2 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2008 VL 173 IS 11 BP 1108 EP 1114 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 372UT UT WOS:000260928200011 PM 19055187 ER PT J AU Perkins, R Simon, J Jayakumar, A Neff, R Cohen, I Bohen, E Oliver, J Kumke, K Older, S Perkins, J Grathwohl, K Yuan, C Abbott, K AF Perkins, Robert Simon, James Jayakumar, Arun Neff, Robert Cohen, Irving Bohen, Erin Oliver, James Kumke, Kevin Older, Steven Perkins, Jeremy Grathwohl, Kurt Yuan, Christina Abbott, Kevin TI Renal Replacement Therapy in Support of Operation Iraqi Freedom: A Tri-Service Perspective SO MILITARY MEDICINE LA English DT Article ID FAILURE; DIALYSIS; MORTALITY; PATIENT; CARE AB Experience with delivery of renal replacement therapy (RRT) in support of combat operations by the U.S. military has not been reported since the 1970s. We describe the tri-service military medical experience with RRT in support of Operation Iraqi Freedom. Through December 31, 2006, RRT was provided to 12 individuals inside the theater of operations. Navy medical personnel provided RRT to three patients (two U.S. active duty service members and one host nation individual) aboard the USNS Comfort, a mobile level 4 hospital. Dialysis was performed using conventional single-pass hemodialysis machines equipped with portable reverse osmosis systems. Army and Air Force medical personnel provided RRT to nine patients in theater (eight host nation patients and one U.S. active duty service member), using peritoneal dialysis and continuous renal replacement therapy (CRRT), not requiring trained renal nurses or technicians. Originally, U.S. military personnel with acute kidney injury (AKI) who were evacuated from theater to Landstuhl Regional Medical Center (LRMC), or those who developed AKI at LRMC were transferred to the German civilian medical system, if RRT was required. After creation of a rapid-response dialysis team and, later, positioning of a full-time active duty reserve nephrologist at LRMC, 16 patients received RRT at LRMC. None had required RRT in theater. Renal failure requiring RRT during combat operations remains an unusual but serious event, calling for flexibility in the provision of care. Notably, the Operation Iraqi Freedom experience has highlighted the needs of injured host nation patients with AKI and future military medical planning will need to account for their intratheater renal care. C1 [Perkins, Robert; Kumke, Kevin] Madigan Army Med Ctr, Dept Med, Serv Nephrol, Ft Lewis, WA 98431 USA. [Jayakumar, Arun] Dept Med, Wright Patterson AFB, OH 45433 USA. [Neff, Robert; Bohen, Erin; Oliver, James; Perkins, Jeremy; Yuan, Christina; Abbott, Kevin] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Cohen, Irving; Grathwohl, Kurt] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Older, Steven] Eisenhower Army Med Ctr, Dept Med, Ft Gordon, GA 30905 USA. RP Perkins, R (reprint author), Madigan Army Med Ctr, Dept Med, Serv Nephrol, Ft Lewis, WA 98431 USA. EM rmperk1@yahoo.com OI Abbott, Kevin/0000-0003-2111-7112 NR 16 TC 6 Z9 6 U1 0 U2 3 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 2008 VL 173 IS 11 BP 1115 EP 1121 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 372UT UT WOS:000260928200012 PM 19055188 ER PT J AU Shen, JS Meng, XL Moore, DF Quirk, JM Shayman, JA Schiffmann, R Kaneski, CR AF Shen, Jin-Song Meng, Xing-Li Moore, David F. Quirk, Jane M. Shayman, James A. Schiffmann, Raphael Kaneski, Christine R. TI Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells SO MOLECULAR GENETICS AND METABOLISM LA English DT Article DE Fabry disease; alpha-Galactosidase A deficiency; Globotriaosylceramide; Endothelial cells; Reactive oxygen species; Cell adhesion molecule ID ENZYME-REPLACEMENT THERAPY; NITRIC-OXIDE SYNTHASE; CEREBRAL HYPERPERFUSION; SUPEROXIDE GENERATION; AGALSIDASE-ALPHA; ATHEROSCLEROSIS; MICE; GLYCOSPHINGOLIPIDS; DEFICIENCY; CHILDREN AB Fabry disease, an X-linked systemic vasculopathy, is caused by a deficiency of alpha-galactosidase A resulting in globotriaosylceramide (Gb(3)) storage in cells. The pathogenic role of Gb(3) in the disease is not known. Based on previous work, we tested the hypothesis that accumulation of Gb(3) in the vascular endothelium of Fabry disease is associated with increased production of reactive oxygen species (ROS) and increased expression of cell adhesion molecules. Gb(3)-loading resulted in increased intracellular ROS production in cultured vascular endothelial cells in a dose-dependent manner. Increased Gb(3) also induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. Reduction of endogenous Gb(3) by treatment of the cells with an inhibitor of glycosphingolipid synthase or alpha-galactosidase A led to decreased expression of adhesion molecules. Plasma from Fabry patients significantly increased ROS generation in endothelial cells when compared with plasma from non-Fabry controls. This effect was not influenced by reduction of intracellular Gb(3). This study provided direct evidence that excess intracellular Gb(3) induces oxidative stress and up-regulates the expression of cellular adhesion molecules in vascular endothelial cells. In addition. other factors in patient's plasma may also contribute to oxidative stress in Fabry vascular endothelial cells. (C) 2008 Elsevier Inc. All rights reserved. C1 [Shen, Jin-Song; Quirk, Jane M.; Schiffmann, Raphael; Kaneski, Christine R.] Natl Inst Neurol Disorders & Stroke, Dev & Metab Neurol Branch, NIH, Bethesda, MD USA. [Meng, Xing-Li] NICHHD, Lab Clin Genome, NIH, Bethesda, MD 20892 USA. [Shayman, James A.] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA. [Shen, Jin-Song; Meng, Xing-Li] Jikei Univ, Sch Med, Inst DNA Med, Dept Gene Therapy, Tokyo, Japan. [Moore, David F.] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. RP Schiffmann, R (reprint author), Natl Inst Neurol Disorders & Stroke, Dev & Metab Neurol Branch, NIH, Bethesda, MD USA. EM Raphael.schiffmann@baylorhealth.edu OI Kaneski, Christine/0000-0003-1453-2502 FU National Institute of Neurological Disorders and Stroke; NIH FX We thank Drs. R.O. Brady and G.J. Murray for discussions. This work was funded by the Intramural Program of the National Institute of Neurological Disorders and Stroke, NIH. NR 36 TC 74 Z9 78 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1096-7192 J9 MOL GENET METAB JI Mol. Genet. Metab. PD NOV PY 2008 VL 95 IS 3 BP 163 EP 168 DI 10.1016/j.ymgme.2008.06.016 PG 6 WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research & Experimental SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental Medicine GA 368DQ UT WOS:000260601900006 PM 18707907 ER PT J AU Nagarajan, S Nagarajan, R Braunhut, SJ Bruno, F McIntosh, D Samuelson, L Kumar, J AF Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Braunhut, Susan J. Bruno, Ferdinando McIntosh, Donna Samuelson, Lynne Kumar, Jayant TI Biocatalytically Oligomerized Epicatechin with Potent and Specific Anti-proliferative Activity for Human Breast Cancer Cells SO MOLECULES LA English DT Article DE Oligomeric catechins; Enzymatic oligomerization; Anti-proliferative activity; Green chemistry; Flavonoids ID GREEN TEA POLYPHENOLS; EPIGALLOCATECHIN GALLATE; CARCINOMA CELLS; CATECHINS; ANTIOXIDANT; POLYMERIZATION; PEROXIDASE; CHROMATOGRAPHY; CONSUMPTION; INHIBITION AB Catechins, naturally occurring flavonoids derived from wine and green tea, are known to exhibit multiple health benefits. Epigallocatechin gallate (EGCG) is one of the most widely investigated catechins, but its efficacy in cancer therapy is still inconsistent and limited. The poor stability of EGCG has contributed to the disparity in the reported anti-cancer activity and other beneficial properties. Here we report an innovative enzymatic strategy for the oligomerization of catechins (specifically epicatechin) that yields stable, water-soluble oligomerized epicatechins with enhanced and highly specific anti-proliferative activity for human breast cancer cells. This one-pot oxidative oligomerization is carried out in ambient conditions using Horseradish Peroxidase (HRP) as a catalyst yielding water-soluble oligo(epicatechins). The oligomerized epicatechins obtained exhibit excellent growth inhibitory effects against human breast cancer cells with greater specificity towards growth-inhibiting cancer cells as opposed to normal cells, achieving a high therapeutic differential. Our studies indicate that water-soluble oligomeric epicatechins surpass EGCG in stability, selectivity and efficacy at lower doses. C1 [Kumar, Jayant] Univ Massachusetts, Dept Phys, Lowell, MA USA. [Nagarajan, Subhalakshmi] Univ Massachusetts, Dept Chem, Lowell, MA USA. [Nagarajan, Ramaswamy] Univ Massachusetts, Dept Plast Engn, Lowell, MA USA. [Braunhut, Susan J.; McIntosh, Donna] Univ Massachusetts, Dept Biol Sci, Lowell, MA USA. [Bruno, Ferdinando; Samuelson, Lynne] USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. [Nagarajan, Subhalakshmi; Kumar, Jayant] Univ Massachusetts, Ctr Adv Mat, Lowell, MA USA. RP Kumar, J (reprint author), Univ Massachusetts, Dept Phys, Lowell, MA USA. EM Jayant_Kumar@uml.edu FU United States Environmental Protection Agency [SU833204]; Office of Congressionally directed medical programs (CDMRP); UMASS Lowell Chancellor's; U. S Army Natick FX Funding from the Environmental Protection Agency P3 program (grant number SU833204), Office of Congressionally directed medical programs (CDMRP), UMASS Lowell Chancellor's seed grant and U. S Army Natick labs is gratefully acknowledged. We wish to thank Dr. Aloke Jain for helpful discussions.; Although the research described in this article has been funded wholly or in part by the United States Environmental Protection Agency through grant/cooperative agreement SU833204 to Dr. Subhalakshmi Nagarajan and Prof. Jayant Kumar, it has not been subjected to the Agency's required peer and policy review and therefore does not necessarily reflect the views of the Agency and no official endorsement should be inferred. NR 28 TC 16 Z9 16 U1 1 U2 9 PU MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI PI BASEL PA KANDERERSTRASSE 25, CH-4057 BASEL, SWITZERLAND SN 1420-3049 J9 MOLECULES JI Molecules PD NOV PY 2008 VL 13 IS 11 BP 2704 EP 2716 DI 10.3390/molecules13112704 PG 13 WC Chemistry, Organic SC Chemistry GA 376QL UT WOS:000261198000001 PM 18978700 ER PT J AU Nykaza, ET Pater, LL Luz, GA AF Nykaza, Edward T. Pater, Larry L. Luz, George A. TI Improved procedure for correlating blast noise events with complaint logs at US Army installations SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID COMMUNITY AB Regulations require Army installations to log and investigate complaints about the noise of military training and operations. A number of Army installations have sought to improve the investigation of complaints by installing monitors specifically designed for measuring impulsive sounds, but the relationship between measured impulse sound levels and noise complaints remains ill-defined. A previous analysis sought to define this relationship but was unable to find corresponding noise measurements for approximately one-third of the complaints. A new study, conducted at the same military installation, has made several technical improvements that have increased the correspondence between noise measurements and complaints. This paper describes the improvements and compares initial findings on the relationship between complaints and blast levels to work previously done. This article is a government work and as such, is in the public domain and not subject to copyright. C1 [Nykaza, Edward T.; Pater, Larry L.] USA, Ctr Res Dev & Engn, Champaign, IL 61826 USA. [Luz, George A.] Luz Social & Environm Associates, Baltimore, MD 21212 USA. RP Nykaza, ET (reprint author), USA, Ctr Res Dev & Engn, POB 9005, Champaign, IL 61826 USA. EM Edward.T.Nykaza@erdc.usace.army.mil; Larry.L.Pater@erdc.usace.army.mil; Luz_Associates@msm.com NR 21 TC 2 Z9 2 U1 0 U2 1 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD NOV-DEC PY 2008 VL 56 IS 6 BP 451 EP 459 PG 9 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 400SL UT WOS:000262888800005 ER PT J AU Wilson, DK Lewis, MS Weatherly, JW Andreas, EL AF Wilson, D. Keith Lewis, Matthew S. Weatherly, John W. Andreas, Edgar L. TI Dependence of predictive skill for outdoor narrowband and broadband sound levels on the atmospheric representation SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article ID LARGE-EDDY SIMULATION; BOUNDARY-LAYER; SURFACE-LAYER; PROPAGATION; MODEL; TURBULENCE; LONG AB Outdoor sound propagation predictions are usually made from averaged, instantaneous, or modeled vertical wind and temperature profiles. Because vertical profiles do not capture the full spatial and temporal variability of the atmosphere, the predictive skill is inherently limited. This study compares bias and root-mean-square (rms) errors for predictions made from the actual mean vertical profiles, approximate vertical profiles based on Monin-Obukhov similarity theory (MOST), and profiles for a windless, neutral atmosphere. The errors are calculated by comparing predictions to "ground-truth" data generated by numerically propagating sound through high-resolution large-eddy simulations of the atmosphere. Predictive errors are found to be similar when actual mean and MOST profiles are used. Assuming a windless, neutral atmosphere leads to a large, positive bias errors in upward refraction, but does not affect skill as much in downward refraction. Analyses are presented for single-frequency signals as well as broadband signals (such as impulse events). It is shown that predictive skill improves as bandwidth is increased, particularly for downwind propagation. (c) 2008 Institute of Noise Control Engineering. C1 [Wilson, D. Keith; Lewis, Matthew S.; Weatherly, John W.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Wilson, DK (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM D.Keith.Wilson@usace.army.mil; Matthew.S.Lewis@usace.army.mil; John.W.Weatherly@usace.army.mil RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 27 TC 3 Z9 3 U1 0 U2 1 PU INST NOISE CONTROL ENGINEERING PI AMES PA IOWA STATE UNIV, COLLEGE ENGINEERING, 212 MARSTON HALL, AMES, IA 50011-2152 USA SN 0736-2501 J9 NOISE CONTROL ENG J JI Noise Control Eng. J. PD NOV-DEC PY 2008 VL 56 IS 6 BP 465 EP 477 PG 13 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA 400SL UT WOS:000262888800007 ER PT J AU Colyer, MH Chun, DW Bower, KS Dick, JSB Weichel, ED AF Colyer, Marcus H. Chun, Dal W. Bower, Kraig S. Dick, John S. B. Weichel, Eric D. TI Perforating Globe Injuries during Operation Iraqi Freedom SO OPHTHALMOLOGY LA English DT Article; Proceedings Paper CT 25th Annual Meeting of the American-Society-of-Retina-Specialists CY DEC, 2007 CL Indian Wells, CA SP Amer Soc Retina Specialists ID EYE INJURY AB Objective: To report the injury patterns associated with perforating (through-and-through) injuries of the globe and the visual impact of these injuries on patients with combat ocular trauma (COT) seen at Walter Reed Army Medical Center (WRAMC) from March 2003 through October 2006. Design: Retrospective, noncomparative, interventional case series. Participants: Sixty-five eyes of 61 United States military soldiers deployed during Operation Iraqi Freedom sustaining perforating globe injuries and treated subsequently at WRAMC. Intervention: Principal procedures included enucleation and 20-gauge 3-port pars plana vitrectomy with or without intraocular foreign body removal. Main Outcome Measures: Final visual acuity and rates of proliferative vitreoretinopathy, enucleation, and endophthalmitis. Results: Average patient age was 29 years, with an average of 200 days of postinjury follow-up (median, 97 days; range, 4-1023 days). Nineteen patients confirmed the use of eye protection at the time of injury, whereas 25 patients did not use eye protection. The median presenting visual acuity at WRAMC was no light perception (range, no light perception to hand movements). Twenty-five patients underwent primary enucleation, 1 was eviscerated, and 12 patients underwent secondary enucleation within 2 weeks of surgery. Of 19 patients undergoing pars plana vitrectomy, median visual acuity at presentation was light perception and the median final visual acuity was counting fingers, whereas 4 eyes (21 %) achieved final visual acuity of better than 20/200, and in 11 (61 %) of 17, proliferative vitreoretinopathy developed over a follow-up of at least 6 months. There were no cases of endophthalmitis or sympathetic ophthalmia. Neither mechanism of injury nor timing of surgery correlated with favorable outcomes. However, entry and exit wounds localized to the anterior half of the globe were associated with favorable anatomic outcome (P < 0.005, Fisher exact test, 2-tailed) and visual outcome (P = 0.041, Fisher exact test, 2-tailed). Conclusions: Perforating globe injuries associated with COT generally result in poor visual and anatomic outcomes despite surgical intervention. Prophylactic measures, such as eye protection, are helpful in reducing the likelihood of perforating injuries; however, novel surgical and pharmacologic therapies will be required to improve the functional and anatomic outcomes of these devastating injuries. C1 [Colyer, Marcus H.; Chun, Dal W.; Bower, Kraig S.; Weichel, Eric D.] Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. [Dick, John S. B.] Kaiser Permanente Hlth Syst, San Diego, CA USA. [Weichel, Eric D.] NEI, NIH, Bethesda, MD 20892 USA. RP Colyer, MH (reprint author), Walter Reed Army Med Ctr, Ophthalmol Clin 1F, Washington, DC 20307 USA. EM marcus.colyer@amedd.army.mil NR 5 TC 41 Z9 46 U1 1 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD NOV PY 2008 VL 115 IS 11 BP 2087 EP 2093 DI 10.1016/j.ophtha.2008.05.013 PG 7 WC Ophthalmology SC Ophthalmology GA 365ZO UT WOS:000260448900036 PM 18672293 ER PT J AU Teitelbaum, ME O'Brien, D Wetzel, ED Goossen, KW AF Teitelbaum, Michael E. O'Brien, Danny Wetzel, Eric D. Goossen, Keith W. TI Mirrored line-of-sight input nodes for embedded optical waveguides SO OPTICAL ENGINEERING LA English DT Article DE fiber optics; optical fiber sensors; plastic optical fiber; free-space optics; data porting; multifunctional materials; smart structures ID WIRELESS SENSOR; FIBER SENSORS; MICROSENSORS; LENSES AB A novel method for passive coupling of light to optical communication links embedded in composite structures has been explored. The use of 45-deg-angled mirrors integrated directly in poly-(methylmethacrylate) fibers as an input node coupling technique was characterized under conditions of varying refractive index. Mirrors were integrated into the fiber through polishing of the endface to a 45-deg angle and then thermal evaporation of Ag metal. To explore angular tolerances and sensitivity to alignment errors, the efficiency of the node was characterized as a function of source position and angle of incidence. Coupling loss as low as -0.39 dB was measured for normal incidence while the input node was immersed in a fluid with refractive index of 1.33. Ray tracing simulations were used to model the coupling of light to fabricated input nodes and showed good agreement with experiments. c 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3028334] C1 [Teitelbaum, Michael E.; Goossen, Keith W.] Univ Delaware, Newark, DE 19716 USA. [O'Brien, Danny; Wetzel, Eric D.] USA, Res Lab, Multifunct Mat Branch, AMSRD ARL WM MA, Aberdeen Proving Ground, MD 21005 USA. RP Teitelbaum, ME (reprint author), Univ Delaware, 140 Evans Hall, Newark, DE 19716 USA. EM mt@udel.edu NR 26 TC 1 Z9 1 U1 0 U2 2 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD NOV PY 2008 VL 47 IS 11 AR 115005 DI 10.1117/1.3028334 PG 8 WC Optics SC Optics GA 377RH UT WOS:000261267800017 ER PT J AU Bottoni, CR Brooks, DE DeBerardino, CTM Owens, MBD Judson, KL Eggers, CJS Mays, DMZ AF Bottoni, Craig R. Brooks, Daniel E. DeBerardino, Col Thomas M. Owens, Maj Breft D. Judson, Kurt L. Eggers, Col Jeffrey S. Mays, Dvm Mary Z. TI A Comparison of Bioabsorbable and Metallic Suture Anchors in a Dynamically Loaded, Intra-articular Caprine Model SO ORTHOPEDICS LA English DT Article ID INTERFERENCE SCREWS; FAILURE STRENGTH; BONE; STABILIZATION; DEGRADATION; FIXATION; TUNNEL C1 [Bottoni, Craig R.] Aspetar Orthopaed & Sports Med Hosp, Doha, Qatar. [Brooks, Daniel E.; Owens, Maj Breft D.; Judson, Kurt L.; Eggers, Col Jeffrey S.; Mays, Dvm Mary Z.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [DeBerardino, Col Thomas M.] Keller Army Hosp, West Point, NY USA. RP Bottoni, CR (reprint author), Aspetar Orthopaed & Sports Med Hosp, POB 29222, Doha, Qatar. NR 17 TC 6 Z9 6 U1 0 U2 3 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD NOV PY 2008 VL 31 IS 11 BP 1106 EP 1110 PG 5 WC Orthopedics SC Orthopedics GA 371TS UT WOS:000260854800014 PM 19226088 ER PT J AU Matos, RI Holcomb, JB Callahan, C Spinella, PC AF Matos, Renee I. Holcomb, John B. Callahan, Charles Spinella, Philip C. TI Increased Mortality Rates of Young Children With Traumatic Injuries at a US Army Combat Support Hospital in Baghdad, Iraq, 2004 SO PEDIATRICS LA English DT Article DE pediatric; trauma; mortality; survival; combat; penetrating ID PEDIATRIC TRAUMA; CARE; ADULT; EXPERIENCE; SEVERITY; FREEDOM; AGE; AFGHANISTAN; CASUALTIES; SURGEONS AB OBJECTIVE. The objective of this study was to determine whether age <= 8 y is an independent predictor of mortality in noncoalition trauma patients at a US combat support hospital. METHODS. A retrospective chart review was conducted of 1132 noncoalition trauma patients who were admitted to a combat support hospital between December 2003 and December 2004. Data on age, severity of injury indices, and in-hospital mortality rates were analyzed. All variables that were associated with death on univariate analysis were analyzed by multivariate logistic regression to determine independent associations with mortality. RESULTS. There were 38 young pediatric patients ( aged <= 8 years) and 1094 older pediatric and adult patients ( aged > 8 years). Penetrating trauma accounted for 83% of all injuries. Young pediatric patients compared with older pediatric and adult patients had increased severity of injury indicated by decreased Glasgow Coma Scale score; increased incidence of hypotension, base deficit, and serum pH on admission; red blood cell transfusion amount; and increased injury severity scores on admission. Young pediatric patients compared with older pediatric and adult patients also had increased ICU lengths of stay ( median 2 [interquartile range 0-5] vs median 0 [ interquartile range 0-2] days) and in-hospital mortality rate (18% vs 4%), respectively. Multivariate logistic regression indicated that base deficit, injury severity score of >= 15, Glasgow Coma Scale score of <= 8, and age of <= 8 years were independently associated with mortality. CONCLUSIONS. Young children who present to a combat support hospital have increased severity of injury compared with older children and adults. In a population with primarily penetrating injuries, after adjustment for severity of injury, young children may also have an independent increased risk for death compared with older children and adults. Providing forward-deployed medical staff with pediatric-specific equipment and training in the acute care of young children with severe traumatic injuries may improve outcomes in this population. Pediatrics 2008; 122: e959-e966 C1 [Matos, Renee I.] Wilford Hall USAF Med Ctr, Dept Pediat, Lackland AFB, TX 78236 USA. [Holcomb, John B.; Spinella, Philip C.] USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. [Callahan, Charles] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Spinella, Philip C.] Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT USA. RP Matos, RI (reprint author), Wilford Hall USAF Med Ctr, Dept Pediat, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. EM reneedlt@gmail.com NR 39 TC 23 Z9 23 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD NOV PY 2008 VL 122 IS 5 BP E959 EP E966 DI 10.1542/peds.2008-1244 PG 8 WC Pediatrics SC Pediatrics GA 367HG UT WOS:000260542500049 PM 18977963 ER PT J AU Sagripanti, JL David Lytle, C AF Sagripanti, Jose-Luis David Lytle, C. TI Response to Comments by Weber and Stilianakis on our Article Entitled, "Inactivation of Influenza Virus by Solar Radiation" SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Letter C1 [Sagripanti, Jose-Luis; David Lytle, C.] USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD USA. RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, Res & Technol Directorate, Aberdeen Proving Ground, MD USA. EM joseluis.sagripanti@us.army.mil NR 2 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD NOV-DEC PY 2008 VL 84 IS 6 BP 1603 EP 1604 DI 10.1111/j.1751-1097.2008.00421.x PG 2 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 374ZC UT WOS:000261081200044 ER PT J AU Ruefenacht, B Finco, MV Nelson, MD Czaplewski, R Helmer, EH Blackard, JA Holden, GR Lister, AJ Salajanu, D Weyermann, D Winterberger, K AF Ruefenacht, B. Finco, M. V. Nelson, M. D. Czaplewski, R. Helmer, E. H. Blackard, J. A. Holden, G. R. Lister, A. J. Salajanu, D. Weyermann, D. Winterberger, K. TI Conterminous US and Alaska Forest Type Mapping Using Forest Inventory and Analysis Data SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID LAND-COVER CLASSIFICATION; UNITED-STATES; DECISION TREES; ECOREGIONS MAP; CLASSIFIERS; RESOLUTION; IMAGERY AB Classification-trees were used to model forest type groups and forest types for the conterminous United States and Alaska. The predictor data were a geospatial data set with a spatial resolution of 250 m developed by the U.S. Department of Agriculture Forest Service (USFS). The response data were plot data from the USFS Forest Inventory and Analysis program. Overall accuracies for the conterminous U.S. for the forest type group and forest type were 69 percent (Kappa = 0.66) and 50 percent (Kappa = 0.57), respectively. The overall accuracies for Alaska for the forest type group and forest type were 78 percent (Kappa = 0.69) and 67 percent (Kappa = 0.61), respectively. This is the first forest type map produced for the U.S. The forest type group map is an update of a previous forest type group map created by Zhu and Evans (1994). C1 [Ruefenacht, B.; Finco, M. V.] USDA Forest Serv, Remote Sensing Applicat Ctr, W Valley City, UT 84119 USA. [Nelson, M. D.] USDA Forest Serv, St Paul, MN 55108 USA. [Czaplewski, R.] Rocky Mt Res Stn, Ft Collins, CO 80526 USA. [Helmer, E. H.] Int Inst Trop Forestry USDA Forest Serv, Rio Piedras, PR 00926 USA. [Blackard, J. A.] US Army Corps Engineers, Ft Worth, TX 76102 USA. [Blackard, J. A.] Rocky Mt Res Stn, Ogden, UT 84401 USA. [Holden, G. R.] Cibola Natl Forest, Albuquerque, NM 87113 USA. [Holden, G. R.] USDA Forest Serv, N Cent Res Stn, St Paul, MN 55108 USA. [Lister, A. J.] NE Res Stn, Newtown Sq, PA 19073 USA. [Salajanu, D.] So Res Stn, Knoxville, TN 37919 USA. [Weyermann, D.] US Forest Serv, Pacific NW Res Stn, Portland, OR 97205 USA. [Winterberger, K.] Pacific NW Res Stn, Anchorage, AK 99503 USA. RP Ruefenacht, B (reprint author), USDA Forest Serv, Remote Sensing Applicat Ctr, 2222 West 2300 South, W Valley City, UT 84119 USA. EM bruefenachtz@fs.fed.us FU USDA Forest Service Forest Inventory and Analysis; Forest Health Protection programs FX We would like to thank Michael Hoppus, Rachel Riemann, Dennis Jacobs, and Gretchen Moisen for their intellectual contributions and support. We also are grateful for the contributions and support of the USDA Forest Service Forest Inventory and Analysis and the Forest Health Protection programs. We appreciate the insightful comments of three anonymous reviewers, which greatly improved the Manuscript. NR 35 TC 62 Z9 65 U1 0 U2 9 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD NOV PY 2008 VL 74 IS 11 BP 1379 EP 1388 PG 10 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 370AH UT WOS:000260734500010 ER PT J AU Ilames, JS Congalton, RG Pilant, AN Lewis, TE AF Ilames, J. S. Congalton, R. G. Pilant, A. N. Lewis, T. E. TI Leaf Area Index (LAI) Change Detection Analysis on Loblolly Pine (Pinus taeda) Following Complete Understory Removal SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID NET PRIMARY PRODUCTION; VEGETATION INDEXES; FOREST STANDS; RAPID ESTIMATION; CANOPY STRUCTURE; PONDEROSA PINE; CONIFER; REFLECTANCE; LANDSAT; VALIDATION AB The confounding effect of understory vegetation contributions to satellite-derived estimates of leaf area index (LAI) was investigated on two loblolly pine (Pines taeda) forest stands located in Virginia and North Carolina. In order to separate NDVI contributions of the dominant-codominate crown class from that of the understroy, two P. taeda 1 ha plots centered in planted stands of ages 19 and 23 years with similar crown closures (71 percent) were analyzed for in situ LAI and NDVI differences following a complete understory removal at the peak period of LAI. Understory vegetation was removed from both stands using mechanical harvest and herbicide application in late July and early August 2002. Ikonos data was acquired both prior and subsequent to understory removal and were evaluated for NDVI response. Total vegetative biomass removed under the canopies was estimated using the Tracing Radiation and Architecture of Canopies (TRAC) instrument combined with digital hemispherical photography (DHP). Within-image NDVI change detection analysis (CDA) on the Virginia site showed that the percentage of removed understory (LAI) detected by the Ikonos sensor was 5.0 percent when compared to an actual in situ LAI reduction of 10.0 percent. The North Carolina site results showed a smaller percentage of reduced understory LAI detected by the Ikonos sensor (1.8 percent) when compared to the actual LAI reduction as measured in situ (17.4 percent). Image-to-image NDVI CDA proved problematic due to the time period between the Ikonos image collections (2.5 to 3 months). Sensor and solar position differences between the two collections, along with pine LAI increases through multiple needle flush, exaggerated NDVI reductions when compared to in situ data. C1 [Ilames, J. S.; Congalton, R. G.] US Environm Protect Agcy, Res Triangle Pk, NC 27709 USA. [Congalton, R. G.] Univ New Hampshire, Durham, NH 03824 USA. [Lewis, T. E.] US Army Corps Engineers, Vicksburg, MS USA. RP Ilames, JS (reprint author), US Environm Protect Agcy, 109 TW Alexander Dr,MD E243-05, Res Triangle Pk, NC 27709 USA. EM iiames.john@epa.gov FU The U.S. Environmental Protection Agency FX The authors wish to express their gratitude to Jerry Hansen of International Paper Corporation and Vick Ford of Mead-Westvaco who facilitated access to the Appomattox and Hertford sites. Ikonos imagery was provided through the NASA Data Buy Program managed by Jeff Morisette and Jaime Nickeson. In addition, John Duncan, Malcolm Wilkins, Milton Bowen, arid Govind Gawdi provided network and logistical support. Administrative, statistical, and technical support was given by John Lyon, L. Dorsey Worthy, Ross Lunetta, David Holland, Megan. Mehaffey, jayantha Ediriwickrema, and Joe Knight. Lastly, we would like. to thank three anonymous reviewers who provided input to this article as well as the UNH Dissertation Committee who critiqued the initial study design and results: John D. Aber, Mark f. Ducey, Mary E. Martin, and M.L. Smith. The U.S. Environmental Protection Agency funded and conducted the research described in this paper. It has been subject to the Agency's programmatic review and has been approved for publication. Mention of any trade names or commercial products does not constitute endorsement or recommendation for use. NR 60 TC 2 Z9 2 U1 0 U2 8 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 USA SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD NOV PY 2008 VL 74 IS 11 BP 1389 EP 1400 PG 12 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA 370AH UT WOS:000260734500011 ER PT J AU Crenshaw, ME AF Crenshaw, Michael E. TI Comparison of quantum and classical local-field effects on two-level atoms in a dielectric SO PHYSICAL REVIEW A LA English DT Article ID INTRINSIC OPTICAL BISTABILITY; SPONTANEOUS EMISSION; MICROSCOPIC DERIVATION; ELECTROMAGNETIC-FIELD; QUANTIZED-FIELD; MEDIA; LIGHT; RADIATION; ELECTRODYNAMICS; REFLECTION AB The macroscopic quantum theory of the electromagnetic field in a dielectric medium interacting with a dense collection of embedded two-level atoms fails to reproduce a result that is obtained from an application of the classical Lorentz local-field condition. Specifically, macroscopic quantum electrodynamics predicts that the Lorentz redshift of the resonance frequency of the atoms will be enhanced by a factor of the refractive index n of the host medium. However, an enhancement factor of (n(2)+2)/3 is derived using the Bloembergen procedure in which the classical Lorentz local-field condition is applied to the optical Bloch equations. Both derivations are short and uncomplicated and are based on well-established physical theories, yet lead to contradictory results. Microscopic quantum electrodynamics confirms the classical local-field-based results. Then the application of macroscopic quantum electrodynamic theory to embedded atoms is proved false by a specific example in which both the correspondence principle and microscopic theory of quantum electrodynamics are violated. C1 USA, AMSRD AMR WS ST, RDECOM, Aviat & Missile RDEC, Redstone Arsenal, AL 35898 USA. RP Crenshaw, ME (reprint author), USA, AMSRD AMR WS ST, RDECOM, Aviat & Missile RDEC, Redstone Arsenal, AL 35898 USA. NR 57 TC 19 Z9 20 U1 0 U2 6 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD NOV PY 2008 VL 78 IS 5 AR 053827 DI 10.1103/PhysRevA.78.053827 PG 10 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 376XF UT WOS:000261215600174 ER PT J AU Simon, DS Sergienko, AV Bahder, TB AF Simon, D. S. Sergienko, A. V. Bahder, T. B. TI Dispersion and fidelity in quantum interferometry SO PHYSICAL REVIEW A LA English DT Article ID HEISENBERG LIMIT; STATE AB We consider Mach-Zehnder and Hong-Ou-Mandel interferometers with nonclassical states of light as input, and study the effect that dispersion inside the interferometer has on the sensitivity of phase measurements. We study in detail a number of different one- and two-photon input states, including Fock, dual Fock, maximally path-entangled parallel to N,0 >+< 0(,)N parallel to ("N00N") states, and photon pairs from parametric down-conversion. Assuming there is a phase shift phi(0) in one arm of the interferometer, we compute the probabilities of measurement outcomes as a function of phi(0), and then compute the Shannon mutual information between phi(0) and the measurements. This provides a means of quantitatively comparing the utility of various input states for determining the phase in the presence of dispersion. In addition, we consider a simplified model of parametric down-conversion for which probabilities can be explicitly computed analytically, and which serves as a limiting case of the more realistic down-conversion model. C1 [Simon, D. S.; Sergienko, A. V.] Boston Univ, Dept Elect & Comp Engn, Boston, MA 02215 USA. [Sergienko, A. V.] Boston Univ, Dept Phys, Boston, MA 02215 USA. [Bahder, T. B.] USA, RDECOM, Charles M Bowden Res Facil, Redstone Arsenal, MA USA. [Bahder, T. B.] USA, RDECOM, Missile Res Dev & Engn Ctr, Redstone Arsenal, MA 35898 USA. RP Simon, DS (reprint author), Boston Univ, Dept Elect & Comp Engn, 8 St Marys St, Boston, MA 02215 USA. FU U. S. Army Research Office (ARO) Multidisciplinary University Research Initiative (MURI) Grant; Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems (CenSSIS); NSF Engineering Research Center; Intelligence Advanced Research Projects Activity (IARPA); ARO [W911NF-07-1-0629] FX This work was supported by a U. S. Army Research Office (ARO) Multidisciplinary University Research Initiative (MURI) Grant, by the Bernard M. Gordon Center for Subsurface Sensing and Imaging Systems (CenSSIS), an NSF Engineering Research Center, and by the Intelligence Advanced Research Projects Activity (IARPA) and ARO through Grant No. W911NF-07-1-0629. NR 14 TC 2 Z9 2 U1 0 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD NOV PY 2008 VL 78 IS 5 AR 053829 DI 10.1103/PhysRevA.78.053829 PG 12 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA 376XF UT WOS:000261215600176 ER PT J AU Folkes, PA Liu, YM AF Folkes, Patrick A. Liu, Yingmei TI Photocurrent-induced changes in the excitonic photoluminescence from a single heterojunction quantum well SO PHYSICAL REVIEW B LA English DT Article DE electron-hole recombination; excitons; photoconductivity; photoexcitation; photoluminescence; semiconductor heterojunctions; semiconductor quantum wells; two-dimensional electron gas ID ELECTRON-HOLE PLASMA; SEMICONDUCTORS; RECOMBINATION; EXPANSION; TRANSPORT; STATE AB Excitons which coexist with a degenerate two-dimensional electron gas (2DEG) in the same quantum well subband have been observed in the photoluminescence (PL) from the recombination of electrons with localized photoexcited holes. Under pulsed photoexcitation at a critical applied voltage, the screening response of the 2DEG/exciton system to the appearance of a remote photocurrent filament in the 2DEG induces an increase in the integrated PL intensity, the formation of long-lifetime excitons in the excitation region, and long-lifetime redshifted PL from the excitation region and the region around the filament. C1 [Folkes, Patrick A.] USA, Res Lab, Adelphi, MD 20783 USA. [Liu, Yingmei] Univ Pittsburgh, Dept Phys, Pittsburgh, PA 15260 USA. RP Folkes, PA (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 19 TC 1 Z9 1 U1 1 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD NOV PY 2008 VL 78 IS 19 AR 193304 DI 10.1103/PhysRevB.78.193304 PG 4 WC Physics, Condensed Matter SC Physics GA 396RC UT WOS:000262607800010 ER PT J AU Postinikova, E Baldwin, C Whitehouse, CA Sechler, A Schaad, NW Sampath, R Harpin, V Li, F Melton, R Blyn, L Drader, J Hofstadler, S Schneider, WL AF Postinikova, E. Baldwin, C. Whitehouse, C. A. Sechler, A. Schaad, N. W. Sampath, R. Harpin, V. Li, F. Melton, R. Blyn, L. Drader, J. Hofstadler, S. Schneider, W. L. TI Identification of Bacterial Plant Pathogens Using Multilocus Polymerase Chain Reaction/Electrospray Ionization-Mass Spectrometry SO PHYTOPATHOLOGY LA English DT Article ID MICROARRAY-BASED DETECTION; RAPID IDENTIFICATION; PRODUCTS; CLEAVAGE; GENES; WATER AB Polymerase chain reaction/electrospray ionization-mass spectrometry (PCR/ESI-MS, previously known as "TIGER") utilizes PCR with broad-range primers to amplify products from a wide array of organisms within a taxonomic group, followed by analysis of PCR amplicons using mass spectrometry. Computer analysis of precise masses allows for calculations of base compositions for the broad-range PCR products, which can then be compared to a database for identification. PCR/ESI-MS has the benefits of PCR in sensitivity and high-throughput capacity, but also has the distinct advantage of being able to detect and identify organisms with no prior characterization or sequence data. Existing broad range PCR primers, designed with an emphasis on human pathogens, were tested for their ability to amplify DNA of well characterized phytobacterial strains, as well as to populate the existing PCR/ESI-MS bacterial database with base counts. In a blinded panel study, PCR/ESI-MS successfully identified 93% of unknown bacterial DNAs to the genus level and 73% to the species/subspecies level. Additionally, PCR/ESI-MS was capable of detecting and identifying multiple bacteria within the same sample. The sensitivity of PCR/ESI-MS was consistent with other PCR based assays, and the specificity varied depending on the bacterial species. Preliminary tests with real life samples demonstrate a high potential for using PCR/ESI-MS systems for agricultural diagnostic applications. C1 [Postinikova, E.; Sechler, A.; Schaad, N. W.; Schneider, W. L.] ARS, USDA, Foreign Dis Weed Sci Res Unit, Ft Detrick, MD 21702 USA. [Baldwin, C.; Whitehouse, C. A.] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. [Sampath, R.; Harpin, V.; Li, F.; Melton, R.; Blyn, L.; Drader, J.; Hofstadler, S.] ISIS Pharmaceut, Ibis Biosci Inc, Carlsbad, CA 92008 USA. RP Schneider, WL (reprint author), ARS, USDA, Foreign Dis Weed Sci Res Unit, 1301 Ditto Ave, Ft Detrick, MD 21702 USA. EM william.schneider@ars.usda.gov FU USDA-NRI Plant Biosecurity Program [2005-35605-15391] FX We thank J. Lewis and M. James for assistance in nucleic acid preparations, and V. Damsteegt and K. Pedley for helpful comments on the manuscript. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the United States Army. This work was supported by the USDA-NRI Plant Biosecurity Program grant 2005-35605-15391. The use of trade, firm, or corporation names in this publication (or page) is for the information and convenience of the reader. Such use does not constitute an official endorsement or approval by the United States Department of Agriculture or the Agricultural Research Service of any product or service to the exclusion of others that may be suitable. NR 25 TC 7 Z9 7 U1 0 U2 1 PU AMER PHYTOPATHOLOGICAL SOC PI ST PAUL PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA SN 0031-949X J9 PHYTOPATHOLOGY JI Phytopathology PD NOV PY 2008 VL 98 IS 11 BP 1156 EP 1164 DI 10.1094/PHYTO-98-11-1156 PG 9 WC Plant Sciences SC Plant Sciences GA 362VZ UT WOS:000260226600001 PM 18943403 ER PT J AU Geisbert, TW Daddario-DiCaprio, KM Lewis, MG Geisbert, JB Grolla, A Leung, A Paragas, J Matthias, L Smith, MA Jones, SM Hensley, LE Feldmann, H Jahrling, PB AF Geisbert, Thomas W. Daddario-DiCaprio, Kathleen M. Lewis, Mark G. Geisbert, Joan B. Grolla, Allen Leung, Anders Paragas, Jason Matthias, Lennox Smith, Mark A. Jones, Steven M. Hensley, Lisa E. Feldmann, Heinz Jahrling, Peter B. TI Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates SO PLOS PATHOGENS LA English DT Article ID ATTENUATED RECOMBINANT VACCINE; HEMORRHAGIC-FEVER; POSTEXPOSURE PROTECTION; REPLICATION-COMPETENT; CYNOMOLGUS MACAQUES; ADENOVIRUS VECTORS; IMMUNE-RESPONSES; MARBURG VIRUSES; MATRIX PROTEIN; INFECTION AB Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as an emerging/re-emerging virus and as a potential biological weapon. Substantial progress has been made over the last decade in developing candidate preventive vaccines that can protect nonhuman primates against EBOV. Among these prospects, a vaccine based on recombinant vesicular stomatitis virus (VSV) is particularly robust, as it can also confer protection when administered as a postexposure treatment. A concern that has been raised regarding the replication-competent VSV vectors that express EBOV glycoproteins is how these vectors would be tolerated by individuals with altered or compromised immune systems such as patients infected with HIV. This is especially important as all EBOV outbreaks to date have occurred in areas of Central and Western Africa with high HIV incidence rates in the population. In order to address this concern, we evaluated the safety of the recombinant VSV vector expressing the Zaire ebolavirus glycoprotein (VSV Delta G/ZEBOVGP) in six rhesus macaques infected with simian-human immunodeficiency virus (SHIV). All six animals showed no evidence of illness associated with the VSV Delta G/ZEBOVGP vaccine, suggesting that this vaccine may be safe in immunocompromised populations. While one goal of the study was to evaluate the safety of the candidate vaccine platform, it was also of interest to determine if altered immune status would affect vaccine efficacy. The vaccine protected 4 of 6 SHIV-infected macaques from death following ZEBOV challenge. Evaluation of CD4+ T cells in all animals showed that the animals that succumbed to lethal ZEBOV challenge had the lowest CD4+ counts, suggesting that CD4+ T cells may play a role in mediating protection against ZEBOV. C1 [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Geisbert, Joan B.] Natl Emerging Infect Dis Labs Inst, Boston, MA USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA. [Geisbert, Thomas W.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA. [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA. [Geisbert, Thomas W.; Jahrling, Peter B.] NIAID, Integrated Res Facil Ft Detrick, NIH, Bethesda, MD 20892 USA. [Geisbert, Thomas W.; Daddario-DiCaprio, Kathleen M.; Geisbert, Joan B.; Hensley, Lisa E.] BIOQUAL, Div Virol, Rockville, MD USA. [Leung, Anders; Jones, Steven M.; Feldmann, Heinz] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB, Canada. [Paragas, Jason; Jahrling, Peter B.] NIAID, Emerging Viral Pathogens Sect, NIH, Bethesda, MD 20892 USA. [Smith, Mark A.] USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. [Jones, Steven M.] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada. RP Geisbert, TW (reprint author), Natl Emerging Infect Dis Labs Inst, Boston, MA USA. EM geisbert@bu.edu FU Defense Threat Reduction Agency [04-4-7J-012]; Canadian Institutes of Health Research [MOP-39321]; Chemical, Biological, Radiological, and Nuclear (CBRN) Research and Technology Initiative (CRTI) FX Work on filoviruses at USAMRIID was funded by the Defense Threat Reduction Agency (project 04-4-7J-012). Work on filoviruses at the NML was supported by PHAC, a grant awarded to HF from the Canadian Institutes of Health Research (MOP-39321), and a grant awarded to SMJ from Chemical, Biological, Radiological, and Nuclear (CBRN) Research and Technology Initiative (CRTI). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by Boston University, the U. S. Army, the National Institutes of Health, or the Public Health Agency of Canada. NR 54 TC 72 Z9 76 U1 2 U2 12 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD NOV PY 2008 VL 4 IS 11 AR e1000225 DI 10.1371/journal.ppat.1000225 PG 9 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 380QV UT WOS:000261481200027 PM 19043556 ER PT J AU Costello, M Sahu, J AF Costello, M. Sahu, J. TI Using computational fluid dynamic/rigid body dynamic results to generate aerodynamic models for projectile flight simulation SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART G-JOURNAL OF AEROSPACE ENGINEERING LA English DT Article DE projectile; flight simulation; computational fluid dynamics ID NAVIER-STOKES COMPUTATIONS; PREDICTION; MISSILE; MOTION AB A method to efficiently generate a complete aerodynamic description for projectile flight dynamic modelling is described. At the core of the method is all unsteady, time accurate Computational fluid dynamic simulation that is tightly coupled to a rigid projectile flight dynamic Simulation. A set of short time snippets Of Simulated projectile motion at different Mach numbers is computed and employed as baseline data. For each time snippet, aerodynamic forces and moments and the full rigid body state vector of the projectile are known. With time synchronized air loads and state vector information, aerodynamic coefficients can be estimated with a simple fitting procedure. By inspecting the condition number of the fitting matrix, it is straightforward to assess the suitability of the time history data to predict a selected set of aerodynamic coefficients. The technique it is exercised on an exemplar fin-stabilized projectile with good results. C1 [Costello, M.] Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. [Sahu, J.] USA, Res Lab, Weapons & Mat Res Directorate, Bethesda, MD USA. RP Costello, M (reprint author), Georgia Inst Technol, Sch Aerosp Engn, Atlanta, GA 30332 USA. EM mark.costello@ae.gatech.edu NR 38 TC 7 Z9 7 U1 1 U2 5 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 0954-4100 J9 P I MECH ENG G-J AER JI Proc. Inst. Mech. Eng. Part G-J. Aerosp. Eng. PD NOV PY 2008 VL 222 IS G7 BP 1067 EP 1079 DI 10.1243/09544100JAERO304 PG 13 WC Engineering, Aerospace; Engineering, Mechanical SC Engineering GA 384WI UT WOS:000261774500014 ER PT J AU King, CS Holley, AB Sherner, JH AF King, Christopher S. Holley, Aaron B. Sherner, John H. TI Severe Bullous Lung Disease Due to Marginal-Zone-Lymphoma-Associated Amyloidosis SO RESPIRATORY CARE LA English DT Article ID B-CELL LYMPHOMA; PRIMARY PULMONARY LYMPHOMA; MALT-TYPE; TISSUE; EXPERIENCE; INFECTION; FEATURES C1 [King, Christopher S.; Holley, Aaron B.; Sherner, John H.] Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, Washington, DC 20307 USA. RP King, CS (reprint author), Walter Reed Army Med Ctr, Dept Pulm & Crit Care Med, 3831 Georgia Ave NW, Washington, DC 20307 USA. EM csking123@hotmail.com NR 33 TC 1 Z9 1 U1 0 U2 0 PU DAEDALUS ENTERPRISES INC PI IRVING PA 9425 N MAC ARTHUR BLVD, STE 100, IRVING, TX 75063-4706 USA SN 0020-1324 J9 RESP CARE JI Respir. Care PD NOV PY 2008 VL 53 IS 11 BP 1495 EP 1498 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 371PU UT WOS:000260844200013 PM 18957153 ER PT J AU James, WF Richardson, WB Soballe, DM AF James, William F. Richardson, William B. Soballe, David M. TI EFFECTS OF RESIDENCE TIME ON SUMMER NITRATE UPTAKE IN MISSISSIPPI RIVER FLOW-REGULATED BACKWATERS SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE backwaters; floodplain rivers; Mississippi River; nitrate uptake; nitrogen ID GULF-OF-MEXICO; NITROGEN SATURATION; AQUATIC ECOSYSTEMS; HEADWATER STREAMS; FLOODPLAIN RIVERS; DETERMINING ORDER; WATER-QUALITY; FLOODED SOIL; DENITRIFICATION; USA AB Nitrate uptake may be improved in regulated floodplain rivers by increasing hydrological connectivity to backwaters. We examined summer nitrate uptake in a series of morphologically similar backwaters on the Upper Mississippi River receiving flow-regulated nitrate loads via gated culverts. Flows into individual back-waters were held constant over a summer period but varied in the summers of 2003 and 2004 to provide a range of hydraulic loads and residence times (tau). The objectives were to determine optimum loading and tau for maximum summer uptake. Higher flow adjustment led to increased loading but lower 1 and contact time for uptake. For highest flows, tau was less than 1 day resulting in lower uptake rates (U(net) < 300 mg m(-2) day(-1)), low uptake efficiency (U% < 20%) and a long uptake length (S(net) > 4000 m). For low flows, tau was greater than 5 days and U% approached 100%, but U(net) was 200mg m(-2) day(-1). S(net) was < half the length of the backwaters under these conditions indicating that most of the load was assimilated in the upper reaches, leading to limited delivery to lower portions. U(net) was maximal (384-629 mg m(-2) day(-1)) for intermediate flows and tau ranging between 1 and 1.5 days. Longer S(net) (2000-4000 m) and lower U% (20-40%) reflected limitation of uptake in upper reaches by contact time, leading to transport to lower reaches for additional uptake. Uptake by similar to 10000ha of reconnected backwaters along the Upper Mississippi River (13% of the total backwater surface area) at a U(net) of similar to 630m m(-2) day(-1) would be the equivalent of similar to 40% of the summer nitrate load (155 mg day(-1)) discharged from Lock and Dam 4. These results indicate that backwater nitrate uptake can play an important role in reducing nitrate loading to the Gulf of Mexico. Copyright (C) 2008 John Wiley & Sons, Ltd. C1 [James, William F.; Soballe, David M.] US Army Corps Engineers, Engineer Res & Dev Ctr, Eau Galle Aquat Ecol Lab, Spring Valley, WI 54767 USA. [Richardson, William B.] US Geol Survey, Upper Midwest Environm Sci Ctr, La Crosse, WI 54603 USA. RP James, WF (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Eau Galle Aquat Ecol Lab, W 500 Eau Galle Dam Rd, Spring Valley, WI 54767 USA. EM william.f.james@erdc.usace.army.mil FU Engineer Research and Development Center; U.S. Army Corps of Engineers FX We gratefully acknowledge H. Eakin and L. Pommier of the Engineer Research and Development Center (ERDC) Eau Galle Aquatic Ecology Laboratory, Spring Valley, Wisconsin, for sampling and chemical analysis and C. Cerco and M. Dortch of the ERDC Environmental Laboratory and anonymous reviewers for helpful comments that greatly improved this manuscript. Funding was provided by the System-Wide Water Resources Programme of the Engineer Research and Development Center, U.S. Army Corps of Engineers. Permission to publish this information was granted by the Chief of Engineers. NR 61 TC 5 Z9 6 U1 2 U2 12 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD NOV PY 2008 VL 24 IS 9 BP 1206 EP 1217 DI 10.1002/rra.1150 PG 12 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 381FE UT WOS:000261520300002 ER PT J AU Niebuhr, DW Millikan, AM Yolken, R Li, YZ Weber, NS AF Niebuhr, David W. Millikan, Amy M. Yolken, Robert Li, Yuanzhang Weber, Natalya S. TI Results From a Hypothesis Generating Case-Control Study: Herpes Family Viruses and Schizophrenia Among Military Personnel SO SCHIZOPHRENIA BULLETIN LA English DT Article DE herpes; virus; schizophrenia; psychosis; antibodies; military ID EPSTEIN-BARR-VIRUS; MATERNAL-FETAL UNIT; CEREBROSPINAL-FLUID; PSYCHIATRIC-PATIENTS; ADULT SCHIZOPHRENIA; CYTOMEGALO-VIRUS; BIPOLAR DISORDER; SIMPLEX TYPE-1; ONSET SCHIZOPHRENIA; MULTIPLE-SCLEROSIS AB Background: Herpes family viruses can cause central nervous system inflammatory changes that can present with symptoms indistinguishable from schizophrenia and therefore are of interest in schizophrenia research. Most existing studies of herpes viruses have used small populations and postdiagnosis specimens. As part of a larger research program, we conducted a hypothesis-generating case-control study of selected herpes virus antibodies among individuals discharged from the US military with schizophrenia and pre- and postdiagnosis sera. Methods: Cases (n = 180) were servicemembers hospitalized and discharged from military service with schizophrenia. Controls, 3:1 matched on several factors, were members not discharged. The military routinely collects and stores members' serum specimens. We used microplate enzyme immunoassay to measure immunoglobulin G (IgG) antibody levels to 6 herpes viruses in pre- and postdiagnosis specimens. Conditional logistic regression was used, and the measure of association was the hazard ratio (HR). Results: Overall, we found a significant association between human herpes virus type 6 and schizophrenia, with an HR of 1.17 (95% confidence interval [CI] = 1.04, 1.32). Women and blacks had significant negative associations with herpes simplex virus type 2 and cytomegalovirus; among blacks, there was a significant positive association with herpes simplex virus type 1. Among men, there was a HHV-6 temporal effect with an HR of 1.41 (95% CI = 1.02, 1.96) for sera drawn 6-12 months before diagnosis. Discussion: Findings from previous studies of herpes family viruses and schizophrenia have been inconsistent. Our study is based on a larger population than most previous studies and used serum specimens collected before onset of illness. This study adds to the body of knowledge and provides testable hypotheses for follow-on studies. C1 [Niebuhr, David W.] Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, Silver Spring, MD 20901 USA. [Yolken, Robert] Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Niebuhr, DW (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, Silver Spring, MD 20901 USA. EM David.Niebuhr@na.amedd.army.mil RI Niebuhr, David/B-7865-2011; OI Li, Yuanzhang/0000-0001-8872-4430 FU Stanley Medical Research Institute, Bethesda, MD; Department of the Army; Funding Cooperative Research and Development Agreement (DAMD) [17-04-0041] FX Stanley Medical Research Institute, Bethesda, MD; Department of the Army; Funding Cooperative Research and Development Agreement ( DAMD control, No: 17-04-0041). NR 55 TC 22 Z9 22 U1 2 U2 5 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0586-7614 J9 SCHIZOPHRENIA BULL JI Schizophr. Bull. PD NOV PY 2008 VL 34 IS 6 BP 1182 EP 1188 DI 10.1093/schbul/sbm139 PG 7 WC Psychiatry SC Psychiatry GA 361OI UT WOS:000260136600024 PM 18156638 ER PT J AU Zhang, H Ye, J Joshi, SP Schoenung, JM Chin, ESC Ramesh, KT AF Zhang, H. Ye, J. Joshi, S. P. Schoenung, J. M. Chin, E. S. C. Ramesh, K. T. TI Rate-dependent behavior of hierarchical Al matrix composites SO SCRIPTA MATERIALIA LA English DT Article DE Hierarchical microstructure; Length-scale effects; Rate-dependent behavior; Metal matrix composite; Strain-to-failure ID ULTRAFINE-GRAINED METALS; STRAIN-RATE; DUCTILITY; STRENGTH; NANOCRYSTALLINE; ALUMINUM; SIZE AB We present the rate-dependent constitutive response of hierarchical Al matrix composites which comprise a bi-modal distribution of Al in fine (nanocrystalline Al containing micro-sized B4C particles) and coarse (micro-grained Al) grain regimes. The strength of these composites is improved by various strengthening mechanisms. Shear localization is observed to be the primary failure mode. Compared to quaistatic loading, significant increase of strain to failure is observed at high strain rates. Varying rate-sensitivity is observed with different amount of B4C particles. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. C1 [Zhang, H.; Joshi, S. P.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Ye, J.; Schoenung, J. M.] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. [Chin, E. S. C.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, H (reprint author), Univ Texas Austin, Ctr Mech Solids Struct & Mat, Austin, TX 78712 USA. EM htzhang@mail.utexas.edu RI Joshi, Shailendra/A-2714-2008 OI Joshi, Shailendra/0000-0002-2141-2851 FU United States Army Research Office [DAAD19-01-2-0003]; Office of Naval Research [N00014-03-C-0163] FX This work was performed under the auspices of the Center for Advanced Metallic and Ceramic Systems (CAMCS) at the Johns Hopkins University and supported by the United States Army Research Office through ARMAC-RTP Cooperative Agreement No. DAAD19-01-2-0003. Partial support of this work (JY and JMS) from the Office of Naval Research under Contract No. N00014-03-C-0163, is gratefully acknowledged. NR 15 TC 18 Z9 18 U1 4 U2 21 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD NOV PY 2008 VL 59 IS 10 BP 1139 EP 1142 DI 10.1016/j.scriptamat.2008.07.036 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 357ZL UT WOS:000259885800029 ER PT J AU Kashi, MR Torres, DM Harrison, SA AF Kashi, Maryam R. Torres, Dawn M. Harrison, Stephen A. TI Current and Emerging Therapies in Nonalcoholic Fatty Liver Disease SO SEMINARS IN LIVER DISEASE LA English DT Review DE Fatty liver; nonalcoholic steatohepatitis (NASH); nonalcoholic fatty liver disease (NAFLD); metabolic syndrome; thiazolidinediones (TZDs) ID PLACEBO-CONTROLLED TRIAL; CANNABINOID-1 RECEPTOR BLOCKER; RANDOMIZED CONTROLLED-TRIAL; GASTRIC BYPASS IMPROVES; LIFE-STYLE MODIFICATION; METABOLIC RISK-FACTORS; VITAMIN-E TREATMENT; INSULIN-RESISTANCE; WEIGHT-LOSS; URSODEOXYCHOLIC ACID AB The prevalence of obesity and the metabolic syndrome (MS) is on the rise, and subsequently the hepatic manifestation of MS, nonalcoholic fatty liver disease (NAFLD), has become a common entity in clinical practice. Most patients with NAFLD face medical complications related to their underlying MS in other organ systems; however, a small but significant group of patients with the more aggressive form of fatty liver, nonalcoholic steatohepatitis (NASH), are at risk of developing cirrhosis and hepatocellular carcinoma. As patients are generally asymptomatic, often their disease goes unrecognized. This is particularly true for NASH, where liver biopsy is currently required to make the diagnosis. Once diagnosed, no one treatment has been shown to be universally efficacious and those that are of benefit are not without side effects. Effective treatment regimens directed at both decreasing insulin resistance as well as the processes leading to necroinflammation and hepatic fibrosis have been investigated and include lifestyle modification, surgical therapies, and pharmacotherapy. This review focuses on current and potential future therapies for NASH. C1 [Torres, Dawn M.; Harrison, Stephen A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Kashi, Maryam R.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. RP Harrison, SA (reprint author), Brooke Army Med Ctr, 3841 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Stephen.harrison@amedd.army.mil NR 83 TC 27 Z9 37 U1 2 U2 3 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA SN 0272-8087 J9 SEMIN LIVER DIS JI Semin. Liver Dis. PD NOV PY 2008 VL 28 IS 4 BP 396 EP 406 DI 10.1055/s-0028-1091984 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 370RG UT WOS:000260779800008 PM 18956296 ER PT J AU Das, NC Bradshaw, J Towner, F Leavitt, R AF Das, Naresh C. Bradshaw, John Towner, Fred Leavitt, R. TI Long-wave (10 mu m) infrared light emitting diode device performance SO SOLID-STATE ELECTRONICS LA English DT Article DE LED device; Surface emitting devices; IR scene projection; LWIR emitters ID SCENE; ARRAYS; LASERS AB Electroluminescence in the range of 6-12 mu m is observed from an Sb-based type-II interband quantum cascade structure. The LED structure has 30 active/injection periods. We have studied both top-emitting and flip-chip mount bottom emitting LED devices. For room temperature operation, an increase. saturation and decrease in light output occur at successively higher injection currents. An increase of about 10 times in light output occurs when device is operated at 77 K compared to room temperature operation. This increase is attributed to reduced Auger non-radiative recombination at lower temperatures. The peak-emission wavelengths at room temperature and 80 K operation are 7 and 10 mu m, respectively. These devices can be used for high-temperature simulation in an infrared scene generation experiment. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Das, Naresh C.] USA, Res Lab, Microphoton Branch, Adelphi, MD 20783 USA. [Bradshaw, John; Towner, Fred; Leavitt, R.] Max Technol Inc, College Pk, MD 20782 USA. RP Das, NC (reprint author), USA, Res Lab, Microphoton Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ndas@arl.army.mil RI Bradshaw, John/E-8330-2011 NR 18 TC 7 Z9 7 U1 3 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD NOV PY 2008 VL 52 IS 11 BP 1821 EP 1824 DI 10.1016/j.sse.2008.09.003 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA 378XS UT WOS:000261358900023 ER PT J AU Kholod, Y Kosenkov, D Okovytyy, S Gorb, L Qasim, M Leszczynski, J AF Kholod, Yana Kosenkov, Dmytro Okovytyy, Sergiy Gorb, Leonid Qasim, Mohammad Leszczynski, Jerzy TI CL-20 photodecomposition: Ab initio foundations for identification of products SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article DE 1H-imidazole; 1H-imidazo[4,5-b]pyrazine; 1,5-dihydrodiimidazo[4,5-b : 4 ' 5 ' e]pyrazine; 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane; (CL-20) photodecomposition; UV spectra; hydrogen bond ID UNIMOLECULAR DECOMPOSITION; DEGRADATION PATHWAYS; ALKALINE-HYDROLYSIS; EXPLOSIVE CL-20; DENSITY; ENERGY; 2,4,6,8,10,12-HEXANITRO-2,4,6,8,10,12-HEXAAZAISOWURTZITANE; MECHANISM; SOIL; APPROXIMATION AB 1,5-Dihydrodiimidazo[4,5-b:4'5'e]pyrazine, 1H-imidazo[4,5-b]pyrazine, and 1H-imidazole were considered as possible products of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) photodecomposition. Since we took as a reference the product obtained after CL-20 irradiation in methanol solution, the nature of intermolecular bonds between heterocycles under study and methanol molecules was analyzed in detail. Existing hydrogen bonds were found to be quite strong, so dependence of calculations results on an influence of solvent was taken into account using both the polarizable continuum model (PCM) and the supermolecular approach. Electronic spectra of 1,5-dihydrodiimidazo[4,5-b:4'5'e]pyrazine, 1H-imidazo[4,5-b]pyrazine and 1H-imidazole were simulated using time dependent density functional theory (TD-DFT) and single-excitation configuration interaction (CIS) method. We observed that TD-DFT excitation energies are lower if compared to corresponding values obtained by the CIS method. Results of calculations with PCM and the supermolecular approach are very close. It was found that differences between calculated gas phase excitation energies and those values obtained by applying solvent models increases when the number of conjugated bonds in a molecule increases. Oscillator strengths of UV bands of the considered molecules are higher in the gas phase than in modeled methanol solutions. We found that the predicted spectrum of I H-imidazole is in close agreement with the experimental UV spectrum of the CL-20 photolysis product. (C) 2008 Elsevier B.V. All rights reserved. C1 [Kholod, Yana; Kosenkov, Dmytro; Okovytyy, Sergiy; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Okovytyy, Sergiy] Dnepropetrovsk Natl Univ, Dept Organ Chem, UA-49050 Dnepropetrovsk, Ukraine. [Gorb, Leonid] USA, Erdc SpecPro, Vicksburg, MS 39180 USA. [Qasim, Mohammad; Leszczynski, Jerzy] USA, Erdc, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, POB 17910,1325 Lynch St, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Kosenkov, Dmytro/B-1483-2009; Okovytyy, Sergiy/F-9838-2010 OI Okovytyy, Sergiy/0000-0003-4367-1309 FU NSF-CREST [HRD-0318519] FX This study was supported by NSF-CREST grant no. HRD-0318519. We appreciate and thank Dr. John Cullinane, ERDC Technical Director for Military Environmental Engineering and Science and Dr. Richard E. Price, Environmental Division Chief, ERDC, for their support and encouragement. Permission was granted by the Chief of Engineers to publish this information. We acknowledge the Mississippi Center for Supercomputer Research for generous allotment of computer time. We also thank Dr. Manoj Shukla for helpful discussions. NR 50 TC 2 Z9 2 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1386-1425 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD NOV 1 PY 2008 VL 71 IS 1 BP 230 EP 237 DI 10.1016/j.saa.2007.12.021 PG 8 WC Spectroscopy SC Spectroscopy GA 357GB UT WOS:000259833200036 PM 18262832 ER PT J AU Dmitriev, AE Gill, NW Kuklo, TR Rosner, MK AF Dmitriev, Anton E. Gill, Norman W. Kuklo, Timothy R. Rosner, Michael K. TI Effect of multilevel lumbar disc arthroplasty on the operative- and adjacent-level kinematics and intradiscal pressures: an in vitro human cadaveric assessment SO SPINE JOURNAL LA English DT Article DE Two-level arthroplasty; Adjacent-segment motion; Adjacent-segment intradiscal pressure; Operative-level kinematics; Segmental kinematics; Total disc replacement ID MOTION SEGMENTS; INTERVERTEBRAL-DISK; SOLUTE TRANSPORT; FUSION; SPINE; MODEL; INSTRUMENTATION; DEGENERATION; NUTRITION; IMPLANTS AB BACKGROUND CONTEXT: With lumbar arthroplasty gaining popularity, limited data are available highlighting changes in adjacent-level mechanics after multilevel procedures. PURPOSE: Compare operative- and adjacent-segment range of motion (ROM) and intradiscal pressures (IDPs) after two-level arthroplasty versus circumferential arthrodesis. STUDY DESIGN: Cadaveric biomechanical study. METHODS: Ten human cadaveric lumbar spines were used in this investigation. Biomechanical testing was performed according to a hybrid testing protocol using an unconstrained spine simulator under axial rotation (AR), flexion extension (FE), and lateral-bending (LB) loading. Specimens were tested in the following order: 1) Intact, 2) L3-L5 total disc replacement (TDR), 3) L3-L5 anterior interbody cages+pedicle screws. IDP was recorded at proximal and distal adjacent levels and normalized to controls (%intact). Full ROM was monitored at the operative and adjacent levels and reported in degrees. RESULTS: Kinematics assessment revealed L3-L5 ROM reduction after both reconstructions versus intact controls (p<.05). However, global quality of segmental motion distributed over L2-S1 was preserved in the arthroplasty group but was significantly altered after circumferential fixation. Furthermore, adjacent-level ROM was increased for the arthrodesis group under LB at both segments and during AR at L2-L3 relative to controls (p<.05). FE did not reveal any intergroup statistical differences. Nonetheless, after arthrodesis IDPs were increased proximally under all three loading modalities, whereas distally a significant IDP rise was noted during AR and LB (p<.05). No statistical differences in either biomechanical parameter were recorded at the adjacent levels between intact control and TDR groups. CONCLUSIONS: Our results indicate no significant adjacent-level biomechanical changes between arthroplasty and control groups. In contrast, significant alterations in ROM and IDP were recorded both proximally (ROM=LB & AR; IDP=AR, FE, LB) and distally (ROM=LB; IDP=AR & LB) after circumferential arthrodesis. Therefore, two-level lumbar arthroplasty maintains a more favorable biomechanical environment at the adjacent segments compared with the conventional transpedicular fixation technique. This, in turn, may have a positive effect on the rate of the transition syndrome postoperatively. (C) 2008 Elsevier Inc. All rights reserved. C1 [Dmitriev, Anton E.; Gill, Norman W.; Kuklo, Timothy R.] Walter Reed Army Med Ctr, Spine Res Ctr, Dept Orthopaed & Rehabil, Washington, DC 20012 USA. [Dmitriev, Anton E.; Gill, Norman W.; Kuklo, Timothy R.] Walter Reed Army Med Ctr, Spine Res Lab, Washington, DC 20012 USA. [Rosner, Michael K.] Walter Reed Army Med Ctr, Dept Surg, Neurosurg Serv, Washington, DC 20012 USA. RP Dmitriev, AE (reprint author), Walter Reed Army Med Ctr, Spine Res Ctr, Dept Orthopaed & Rehabil, POB 59037, Washington, DC 20012 USA. EM aedortho@gmail.com NR 26 TC 24 Z9 25 U1 3 U2 5 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD NOV-DEC PY 2008 VL 8 IS 6 BP 918 EP 925 DI 10.1016/j.spinee.2007.10.034 PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 373KN UT WOS:000260970600008 PM 18178528 ER PT J AU Lam, DM Poropatich, RK AF Lam, David M. Poropatich, Ronald K. TI Telemedicine Deployments Within NATO Military Forces: A Data Analysis of Current and Projected Capabilities SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article DE military medicine; teleradiology; policy; telemedicine ID ENVIRONMENT AB Since the creation of the NATO Telemedicine Expert Panel ( now renamed the TMED Expert Team) in 2000, when few nations had deployed telemedicine systems to support military field operations, this group has been encouraging the nations to deploy telemedicine ( TMED) in support of their forces, and to write the use of TMED into NATO doctrine. This has been a relatively successful effort, and TMED is increasingly being used within the military medical structures of some NATO and Partnership for Peace nations to provide medical care to deployed military personnel. We report the results of a multinational survey of current and projected availability of various telemedicine modalities within the NATO medical services that are participating in the work of the TMED expert team ( ET). Though only a "snapshot in time," and not representing all NATO nations, this is the first attempt to identify both current and planned TMED utilization within the multinational military medical community. Participating nations report that communication systems now in place at the lowest levels of medical support increasingly enable the routine use of Web-based teleconsultation modalities. Teleradiology is now being seen as the de facto standard for imaging support. While a number of nations report they have deployed capabilities for obtaining clinical consultations at a distance, most responding nations do not have a formal organizational structure to control and manage remote consultation and rely on informal clinical relationships (e. g., requesting consults from the deployed clinician's home hospital or from friends). Military electronic health records are in use by only a minority of nations and fewer still are capable of civilian interface. Less common TMED capabilities (e. g., tele-microbiology, tele-pathology, tele-medical maintenance) are being increasingly used, but are still rarely deployed. As a result of the findings of this survey, specific recommendations for expanding the use of TMED in the NATO multinational medical setting have been made to appropriate NATO bodies. C1 [Lam, David M.; Poropatich, Ronald K.] USA, Med Res & Mat Command, TATRC, Ft Detrick, MD USA. [Lam, David M.] Univ Maryland, Sch Med, Natl Study Ctr Trauma & EMS, Baltimore, MD 21201 USA. RP Lam, DM (reprint author), USA, TATRC, PSC 79,Box 145, APO, AE 09714 USA. EM lam@tatrc.org NR 10 TC 8 Z9 8 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD NOV PY 2008 VL 14 IS 9 BP 946 EP 951 DI 10.1089/tmj.2008.0018 PG 6 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 382AU UT WOS:000261577800046 PM 19035805 ER PT J AU Shoop, SA Coutermarsh, B Ayers, P Anderson, A Affleck, R AF Shoop, Sally A. Coutermarsh, Barry Ayers, Paul Anderson, Alan Affleck, Rosa TI TIRE FORCE AND TERRAIN DISTURBANCE MEASUREMENTS DURING TURNING MANEUVERS SO TRANSACTIONS OF THE ASABE LA English DT Article DE Damage; Disturbance; Environment; Force; Impact; Maneuver; Military; Mobility; Performance; Terrain; Vegetation; Vehicle AB A proof-of-concept study to link vehicle performance measures to associated terrain disturbance was performed with the intent to improve terrain impact prediction methods. Field tests to assess terrain disturbance during turning maneuvers were completed on dry and wet, grassy fields and slopes in northern Vermont. The vehicle tests consisted of a series of spiral maneuvers at two speeds, and serpentine maneuvers on slopes, to comprise a range of turning radii, upslope and downslope turns, and velocity. The CRREL instrumented vehicle (CIV) and a military high-mobility multipurpose wheeled vehicle (HMMWV) were instrumented to measure linear accelerations, angular and linear velocity, wheel forces, speeds, and location. The terrain was fully characterized for soil type, wetness, shear strength, and vegetation cover prior to testing. The disturbance created by the vehicle was measured using the cumulative impact width method based on disturbed width and impact severity. Results show increased disturbance for the wetter soil, but generally the impacts were low because of sufficient terrain strength for these two vehicles. Nonetheless, correlations were found between the measured horizontal forces, accelerations and yaw rates, and the terrain disturbance; most significantly, increased lateral tire-terrain interface forces resulted in increased cumulative impact width. Additionally, the vehicle lateral force, accerlation, and yaw rate that were directly measured are comparable with those calculated from the global positioning system (GPS) data, illustrating the potential of the much simpler measurements for this purpose. C1 [Shoop, Sally A.; Coutermarsh, Barry; Affleck, Rosa] USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, Hanover, NH 03755 USA. [Ayers, Paul] Univ Tennessee, Dept Biosyst Engn, Knoxville, TN USA. [Anderson, Alan] USAERDC, Construct Engn Res Lab, Champaign, IL USA. RP Shoop, SA (reprint author), USA, Cold Reg Res & Engn Lab, Engn Res & Dev Ctr, 72 Lyme Rd, Hanover, NH 03755 USA. EM sally.a.shoop@usace.army.mil NR 23 TC 1 Z9 1 U1 0 U2 3 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 0001-2351 J9 T ASABE JI Trans. ASABE PD NOV-DEC PY 2008 VL 51 IS 6 BP 1869 EP 1878 PG 10 WC Agricultural Engineering SC Agriculture GA 399UW UT WOS:000262825800001 ER PT J AU Krishnani, KK Meng, XG Boddu, VM AF Krishnani, K. K. Meng, Xiaoguang Boddu, Veera M. TI Fixation of Heavy Metals onto Lignocellulosic Sorbent Prepared from Paddy Straw SO WATER ENVIRONMENT RESEARCH LA English DT Article DE fixation; mechanism; heavy metals; paddy straw ID SUGAR-INDUSTRY WASTE; NICA-DONNAN APPROACH; BAGASSE FLY-ASH; WHEAT BRAN; HEXAVALENT CHROMIUM; AQUEOUS-SOLUTIONS; COPPER(II) REMOVAL; IONS BINDING; COCONUT HUSK; BEET PULP AB The sorption behavior of biosorbent prepared from paddy straw with nine different heavy metals has been studied. The binding mechanisms involving adsorption and the cation-exchange process have also been investigated. Characterization of biosorbent through a scanning electron microscope revealed no major surface deformity resulting from the chemical treatment. X-ray photo electron spectroscopy was also used to determine the presence of exchangeable cations in the sorbent and the speciation of bound chromium, cadmium, and mercury. The maximum sorption capacity (millimoles/gram) obtained from the Langmuir model for Pb(2+), Cd(2+), Hg(2+), Co(2+), Ni(2+), Mn(2+), Zn(2+), and Cu(2+) were 0.286, 0.147, 0.226, 0.181, 0.196, 0.189, 0.219, and 0.248, respectively. Interpretation of Dahlquist (1978) and Scatchard (1949) was also used for the binding site heterogeneity. The unique ability of the biosorbent to bind nine different metals has been attributed to the presence of surface heterogeneity and Ca(2+) ions, which attract and sequester metal ions. Biosorption results are useful for the development of low-cost biosorbent. Water Environ. Res., 80, 2165 (2008). C1 [Krishnani, K. K.] Cent Inst Brackishwater Aquaculture, Madras 600028, Tamil Nadu, India. [Meng, Xiaoguang] Stevens Inst Technol, Ctr Environm Engn, Hoboken, NJ 07030 USA. [Boddu, Veera M.] USA, Construct Engn Res Lab, Environm Proc Branch, Engineer Res & Dev Ctr, Champaign, IL 61824 USA. RP Krishnani, KK (reprint author), Cent Inst Brackishwater Aquaculture, 75 Santhome High Rd, Madras 600028, Tamil Nadu, India. EM scientistk@hotmail.com RI Krishnani, K/B-2553-2012 OI Krishnani, K/0000-0003-2774-7772 FU Department of Biotechnology, Ministry of Science and Technology, Government of India FX The Department of Biotechnology, Ministry of Science and Technology, Government of India, is gratefully acknowledged for awarding the Biotechnology Overseas Associateship to K. K. Krishnani. NR 46 TC 11 Z9 11 U1 3 U2 12 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD NOV PY 2008 VL 80 IS 11 BP 2165 EP 2174 DI 10.2175/106143008X304785 PG 10 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA 375QO UT WOS:000261128600009 PM 19024732 ER PT J AU Rutvisuttinunt, W Meyer, PR Scott, WA AF Rutvisuttinunt, Wiriya Meyer, Peter R. Scott, Walter A. TI Interactions between HIV-1 Reverse Transcriptase and the Downstream Template Strand in Stable Complexes with Primer-Template SO PLOS ONE LA English DT Article AB Background: Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) forms stable ternary complexes in which RT is bound tightly at fixed positions on the primer-template (P/T). We have probed downstream interactions between RT and the template strand in the complex containing the incoming dNTP (+1 dNTP.RT.P/T complex) and in the complex containing the pyrophosphate analog, foscarnet (foscarnet.RT.P/T complex). Methods and Results: UV-induced cross-linking between RT and the DNA template strand was most efficient when a bromodeoxyuridine residue was placed in the +2 position (the first template position downstream from the incoming dNTP). Furthermore, formation of the +1 dNT.RT.P/T complex on a biotin-containing template inhibited binding of streptavidin when biotin was in the +2 position on the template but not when the biotin was in the +3 position. Streptavidin pre-bound to a biotin residue in the template caused RT to stall two to three nucleotides upstream from the biotin residue. The downstream border of the complex formed by the stalled RT was mapped by digestion with exonuclease RecJF. UV-induced cross-linking of the complex formed by the pyrophosphate analog, foscarnet, with RT and P/T occurred preferentially with bromodeoxyuridine in the +1 position on the template in keeping with the location of RT one base upstream in the foscarnet.RT.P/T complex (i.e., in the pre-translocation position). Conclusions: For +1 dNTP.RT.P/T and foscarnetNRTNP/T stable complexes, tight interactions were observed between RT and the first unpaired template nucleotide following the bound dNTP or the primer terminus, respectively. C1 [Rutvisuttinunt, Wiriya; Meyer, Peter R.; Scott, Walter A.] Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Coral Gables, FL 33124 USA. RP Rutvisuttinunt, W (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. EM wscott@med.miami.edu FU National Institute of Allergy and Infectious Disease [AI-39973]; American Heart Association Predoctoral Fellowship [025082B]; American Foundation for AIDS Research Postdoctoral Fellowship [70567-31-RF] FX The work was supported by the National Institute of Allergy and Infectious Disease (AI-39973 to W.A.S.), the American Heart Association Predoctoral Fellowship (025082B to W.R.), and the American Foundation for AIDS Research Postdoctoral Fellowship (70567-31-RF to P.R.M.). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 39 TC 1 Z9 1 U1 0 U2 5 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 30 PY 2008 VL 3 IS 10 AR e3561 DI 10.1371/journal.pone.0003561 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 432KI UT WOS:000265131500001 PM 18974785 ER PT J AU Dent, AE Bergmann-Leitner, ES Wilson, DW Tisch, DJ Kimmel, R Vulule, J Sumba, PO Beeson, JG Angov, E Moormann, AM Kazura, JW AF Dent, Arlene E. Bergmann-Leitner, Elke S. Wilson, Danny W. Tisch, Daniel J. Kimmel, Rhonda Vulule, John Sumba, Peter Odada Beeson, James G. Angov, Evelina Moormann, Ann M. Kazura, James W. TI Antibody-Mediated Growth Inhibition of Plasmodium falciparum: Relationship to Age and Protection from Parasitemia in Kenyan Children and Adults SO PLOS ONE LA English DT Article AB Background: Antibodies that impair Plasmodium falciparum merozoite invasion and intraerythrocytic development are one of several mechanisms that mediate naturally acquired immunity to malaria. Attempts to correlate anti-malaria antibodies with risk of infection and morbidity have yielded inconsistent results. Growth inhibition assays (GIA) offer a convenient method to quantify functional antibody activity against blood stage malaria. Methods: A treatment-time-to-infection study was conducted over 12-weeks in a malaria holoendemic area of Kenya. Plasma collected from healthy individuals (98 children and 99 adults) before artemether-lumefantrine treatment was tested by GIA in three separate laboratories. Results: Median GIA levels varied with P. falciparum line (D10, 8.8%; 3D7, 34.9%; FVO, 51.4% inhibition). The magnitude of growth inhibition decreased with age in all P. falciparum lines tested with the highest median levels among children,4 years compared to adults (e.g. 3D7, 45.4% vs. 30.0% respectively, p = 0.0003). Time-to-infection measured by weekly blood smears was significantly associated with level of GIA controlling for age. Upper quartile inhibition activity was associated with less risk of infection compared to individuals with lower levels (e.g. 3D7, hazard ratio = 1.535, 95% CI = 1.012-2.329; p = 0.0438). Various GIA methodologies had little effect on measured parasite growth inhibition. Conclusion: Plasma antibody-mediated growth inhibition of blood stage P. falciparum decreases with age in residents of a malaria holoendemic area. Growth inhibition assay may be a useful surrogate of protection against infection when outcome is controlled for age. C1 [Dent, Arlene E.; Tisch, Daniel J.; Kimmel, Rhonda; Moormann, Ann M.; Kazura, James W.] Case Western Reserve Univ, Cleveland, OH 44106 USA. [Bergmann-Leitner, Elke S.; Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA. [Wilson, Danny W.; Beeson, James G.] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia. [Wilson, Danny W.] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia. [Vulule, John; Sumba, Peter Odada] Kenya Govt Med Res Ctr, Kisumu, Kenya. RP Dent, AE (reprint author), Case Western Reserve Univ, Cleveland, OH 44106 USA. EM jxk14@po.cwru.edu RI Bergmann-Leitner, Elke/B-3548-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956 FU NIH [AI43906, AI0702427]; National Health and Medical Research Council of Australia FX This research was funded by NIH grant AI43906 (JWK) and the National Health and Medical Research Council of Australia (Career Development Award and project grant to JGB; postgraduate scholarship to DWW). AED was supported by NIH training grant AI0702427. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NR 64 TC 42 Z9 42 U1 1 U2 3 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD OCT 29 PY 2008 VL 3 IS 10 AR e3557 DI 10.1371/journal.pone.0003557 PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 432KE UT WOS:000265131100015 PM 18958285 ER PT J AU Bolles, JA Gentlesk, PJ Lewis, PC Ross, RD Eckert, RE AF Bolles, Jonathan A. Gentlesk, Philip J. Lewis, Paul C. Ross, Ronald D. Eckert, Robert E. TI Triage and Evacuation of Young Patients with Syncope in a Combat Theater of Operations SO CIRCULATION LA English DT Meeting Abstract CT 81st Annual Scientific Session of the American-Heart-Association CY NOV 08-12, 2008 CL New Orleans, LA SP Amer Heart Assoc C1 [Bolles, Jonathan A.; Gentlesk, Philip J.; Lewis, Paul C.; Eckert, Robert E.] Brooke Army Med Ctr, San Antonio, TX USA. [Ross, Ronald D.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 28 PY 2008 VL 118 IS 18 BP S675 EP S675 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 389ON UT WOS:000262104502165 ER PT J AU Dominguez, F Beekley, AC Huffer, LL Gentlesk, PJ Eckert, RE AF Dominguez, Francisco Beekley, Alec C. Huffer, Linda L. Gentlesk, Philip J. Eckert, Robert E. TI High Velocity Penetrating Thoracic Trauma with Suspected Cardiac Involvement in Combat During Operation Iraqi Freedom SO CIRCULATION LA English DT Meeting Abstract CT 81st Annual Scientific Session of the American-Heart-Association CY NOV 08-12, 2008 CL New Orleans, LA SP Amer Heart Assoc C1 [Dominguez, Francisco; Gentlesk, Philip J.; Eckert, Robert E.] Brooke Army Med Ctr, San Antonio, TX USA. [Beekley, Alec C.] Madigan Army Med Ctr, Ft Lewis, WA USA. [Huffer, Linda L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 28 PY 2008 VL 118 IS 18 BP S665 EP S665 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 389ON UT WOS:000262104502125 ER PT J AU Ji, SY Ward, K Ryan, K Rickard, C Convertino, V Najarian, K AF Ji, Soo-Yeon Ward, Kevin Ryan, Kathy Rickard, Caroline Convertino, Victor Najarian, Kayvan TI Heart Rate Variability Analysis using Wavelet Transform to Predict Hemorrhage Severity SO CIRCULATION LA English DT Meeting Abstract CT 81st Annual Scientific Session of the American-Heart-Association CY NOV 08-12, 2008 CL New Orleans, LA SP Amer Heart Assoc C1 [Ji, Soo-Yeon] Virginia Commonwealth Univ, Richmond, VA USA. [Ward, Kevin; Najarian, Kayvan] Virginia Commonwealth Univ, Reanimat Engn Shock Ctr, Richmond, VA USA. [Ryan, Kathy; Rickard, Caroline; Convertino, Victor] USA, Inst Surg Rsch, San Antonio, TX USA. RI Najarian, Kayvan/B-2303-2010 NR 0 TC 0 Z9 0 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 28 PY 2008 VL 118 IS 18 BP S1465 EP S1465 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 389ON UT WOS:000262104504754 ER PT J AU Munir, J Bindeman, J Bauer, K Byrd, C Wu, H O'Malley, P Taylor, A AF Munir, Jamalah Bindeman, Jody Bauer, Kelly Byrd, Carole Wu, Holly O'Malley, Patrick Taylor, Allen TI Impact of the MESA Arterial Age Calculator Incorporating Coronary Calcium on CHD Risk Estimation SO CIRCULATION LA English DT Meeting Abstract CT 81st Annual Scientific Session of the American-Heart-Association CY NOV 08-12, 2008 CL New Orleans, LA SP Amer Heart Assoc C1 [Munir, Jamalah; Bindeman, Jody; Bauer, Kelly; Byrd, Carole; Wu, Holly; O'Malley, Patrick; Taylor, Allen] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 28 PY 2008 VL 118 IS 18 BP S1120 EP S1120 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 389ON UT WOS:000262104504447 ER PT J AU Summers, RL Ward, K Witten, T Convertino, V Ryan, K Coleman, TG Hester, R AF Summers, Richard L. Ward, Kevin Witten, Tarynn Convertino, Victor Ryan, Kathy Coleman, Thomas G. Hester, Robert TI Validation of a Computational Platform for the Analysis of the Physiologic Mechanisms of a Human Experimental Model of Hemorrhage SO CIRCULATION LA English DT Meeting Abstract CT 81st Annual Scientific Session of the American-Heart-Association CY NOV 08-12, 2008 CL New Orleans, LA SP Amer Heart Assoc C1 [Summers, Richard L.; Coleman, Thomas G.; Hester, Robert] Univ Mississippi Med C, Jackson, MS USA. [Ward, Kevin; Witten, Tarynn] Virginia Commonwealth Univ, Reanimat Engn Shock Cntr, Richmond, VA USA. [Convertino, Victor; Ryan, Kathy] USA, Inst Surg Res, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 28 PY 2008 VL 118 IS 18 BP S1446 EP S1446 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 389ON UT WOS:000262104504669 ER PT J AU Tiba, MH Ryan, K Torres, I Rickards, C Witten, TM Soller, B Convertino, V Ward, K AF Tiba, M. H. Ryan, Kathy Torres, Ivo Rickards, Carloine Witten, Tarynn M. Soller, Babs Convertino, Victor Ward, Kevin TI Oxygen Transport Characterization of a Human Model of Hemorrhage SO CIRCULATION LA English DT Meeting Abstract CT 81st Annual Scientific Session of the American-Heart-Association CY NOV 08-12, 2008 CL New Orleans, LA SP Amer Heart Assoc C1 [Tiba, M. H.; Torres, Ivo; Witten, Tarynn M.; Ward, Kevin] Virginia Commonwealth Univ, Reanimat Engn Shock Ctr, Richmond, VA USA. [Ryan, Kathy; Rickards, Carloine; Convertino, Victor] USA, Inst Surg Res, San Antonio, TX USA. [Soller, Babs] Univ Massachusetts, Sch Med, Worcester, MA USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT 28 PY 2008 VL 118 IS 18 BP S1447 EP S1447 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA 389ON UT WOS:000262104504673 ER PT J AU Koblmuller, G Hirai, A Wu, F Gallinat, CS Metcalfe, GD Shen, H Wraback, M Speck, JS AF Koblmueller, G. Hirai, A. Wu, F. Gallinat, C. S. Metcalfe, G. D. Shen, H. Wraback, M. Speck, J. S. TI Molecular beam epitaxy and structural anisotropy of m-plane InN grown on free-standing GaN SO APPLIED PHYSICS LETTERS LA English DT Article ID NITRIDE; FILMS; SAPPHIRE; DIODES AB This study reports on the growth of high-quality nonpolar m-plane [1 (1) over bar 00] InN films on free-standing m-plane GaN substrates by plasma-assisted molecular beam epitaxy. Optimized growth conditions (In/ N ratio similar to 1 and T= 390-430 degrees C) yielded very smooth InN films with undulated features elongated along the [11 (2) over bar 20] orientation. This directionality is associated with the underlying defect structure shown by the anisotropy of x- ray rocking curve widths parallel to the [11 (2) over bar0] (i. e., 0.24 degrees- 0.34 degrees) and [0001] (i. e., 1.2 degrees-2.7 degrees) orientations. Williamson-Hall analysis and transmission electron microscopy identified the mosaic tilt and lateral coherence length and their associations with different densities of dislocations and basal-plane stacking faults. Ultimately, very low band gap energies of similar to 0.67 eV were measured by optical absorption similar to the best c-plane InN. (C) 2008 American Institute of Physics. [DOI: 10.1063/1.3001806] C1 [Koblmueller, G.; Hirai, A.; Wu, F.; Gallinat, C. S.; Speck, J. S.] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. [Metcalfe, G. D.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Koblmuller, G (reprint author), Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA. EM gregor@engineering.ucsb.edu RI Gallinat, Chad/E-7561-2010; Speck, James/H-5646-2011; Wu, Feng/D-5641-2015 FU NSF FX The authors acknowledge the fruitful discussions with Professor C. Van de Walle (UCSB) and the support of AFOSR (D. J. Silversmith, program manager) and SSLEC (UCSB). The experimental work made use of the MRSEC facilities at UCSB (supported by the NSF). NR 26 TC 38 Z9 38 U1 1 U2 11 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 27 PY 2008 VL 93 IS 17 AR 171902 DI 10.1063/1.3001806 PG 3 WC Physics, Applied SC Physics GA 367SD UT WOS:000260571800017 ER PT J AU Ifarraguerri, A Ben-David, A AF Ifarraguerri, Agustin Ben-David, Avishai TI Impact of atmospheric boundary layer turbulent temperature fluctuations on remote detection of vapors by passive infrared spectroscopy SO OPTICS EXPRESS LA English DT Article AB A computational model to simulate the effects of boundary layer isotropic atmospheric turbulence on the radiative transfer process is presented. We perform a large number of simulations with stochastic ambient conditions to estimate the statistics necessary to predict the detection limit of a given trace gas. We find that the radiance and transmittance variability are primarily determined by the optical depth of the emitting atmosphere, and that the relative variability of the transmittance is an order of magnitude smaller than that of the radiance. We estimate that the atmospheric detection limit of a DMMP vapor cloud at 30 meters altitude for a ground-based observer ranges from 3.5 to 12 ppbm, depending on the horizontal range to the cloud. Addition of uncorrelated detector noise has a disproportionate effect on the detection limit over the spectrally correlated turbulence noise. These calculations appear to be the first predictions of vapor detection limits that explicitly incorporate the effects of turbulence. (C) 2008 Optical Society of America C1 [Ifarraguerri, Agustin] Sci Applicat Int Corp, Arlington, VA 22203 USA. [Ben-David, Avishai] USA, REDECOM, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. RP Ifarraguerri, A (reprint author), Sci Applicat Int Corp, 4001 N Fairfax Dr, Arlington, VA 22203 USA. EM agustin.i.ifarraguerri@saic.com FU U. S. Army Edgewood Chemical and Biological Center [W91ZLK-07-P-0446] FX This work was funded by the U. S. Army Edgewood Chemical and Biological Center under contract W91ZLK-07-P-0446. NR 15 TC 5 Z9 5 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 27 PY 2008 VL 16 IS 22 BP 17366 EP 17382 DI 10.1364/OE.16.017366 PG 17 WC Optics SC Optics GA 371XL UT WOS:000260865900027 PM 18958020 ER PT J AU Duby, JM Difurio, MJ AF Duby, Jeanne M. Difurio, Megan J. TI ASC-US And High-Risk HPV Rates: Imager Detected Cases Versus Historical Manual Screening SO CANCER CYTOPATHOLOGY LA English DT Meeting Abstract C1 [Duby, Jeanne M.; Difurio, Megan J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER CYTOPATHOL JI Cancer Cytopathol. PD OCT 25 PY 2008 VL 114 IS 5 SU S BP 380 EP 381 PG 2 WC Oncology; Pathology SC Oncology; Pathology GA 361PY UT WOS:000260140800060 ER PT J AU Buchheit, AA Hilmas, GE Fahrenholtz, WG Deason, DM Wang, H AF Buchheit, Andrew A. Hilmas, Greg E. Fahrenholtz, William G. Deason, Douglas M. Wang, Hsin TI Mechanical and thermal properties of AlN-BN-SiC ceramics SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Aluminum nitride; Boron nitride; Silicon carbide; Mechanical properties; Thermal properties; Hot pressing ID BORON NITRIDE COMPOSITES; SITU REACTION SYNTHESIS; SILICON-CARBIDE; FABRICATION; SYSTEM AB Mechanical and thermal properties were characterized for two AlN:BN:SiC composite ceramics produced from BN with different particle sizes. The ceramics were hot pressed at temperatures from 1950 to 2100 degrees C to similar to 97% relative density. For both materials, the matrix (90:10 vol% SiC:AlN) had a grain size of similar to 0.4 mu m, and the BN grains (10 vol%) were crystallographically aligned. Microhardness values were between 20 and 22 GPa, while fracture toughness values were between 2.5 and 3.1 MPa m(1/2). Other Properties were found to be dependent on testing direction. Elastic moduli were between 260 and 300 GPa and strengths were similar to 630 MPa for small particle BN additions. Thermal conductivity was calculated to be between 25 and 37W/m K at room temperature and 17 and 25 W/m K at 900 degrees C. The low values compared to traditional SiC ceramics were attributed to AlN-SiC solid solution formation and sub-micron matrix grain sizes. (C) 2008 Elsevier B.V. All rights reserved. C1 [Buchheit, Andrew A.; Hilmas, Greg E.; Fahrenholtz, William G.] Missouri Univ Sci & Technol, Dept Mat Sci & Engn, Rolla, MO 65409 USA. [Deason, Douglas M.] USA, Space & Missile Def Command, Redstone Arsenal, AL 35898 USA. [Wang, Hsin] Oak Ridge Natl Lab, High Temp Mat Lab, Oak Ridge, TN 37831 USA. RP Hilmas, GE (reprint author), Missouri Univ Sci & Technol Missouri S & T, Dept Mat Sci & Engn, 222 McNutt Hall,1400 N Bishop Ave, Rolla, MO 65409 USA. EM aab@mst.edu; ghilmas@mst.edu RI Wang, Hsin/A-1942-2013; OI Wang, Hsin/0000-0003-2426-9867; Fahrenholtz, William/0000-0002-8497-0092 NR 28 TC 10 Z9 10 U1 1 U2 14 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 EI 1873-4936 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 25 PY 2008 VL 494 IS 1-2 SI SI BP 239 EP 246 DI 10.1016/j.msea.2008.05.051 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 359JU UT WOS:000259983700034 ER PT J AU Nayak, SS Misra, RDK Hartmann, J Siciliano, F Gray, JM AF Nayak, S. S. Misra, R. D. K. Hartmann, J. Siciliano, F. Gray, J. M. TI Microstructure and properties of low manganese and niobium containing HIC pipeline steel SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE Pipeline steels; Microstructure; Low manganese; Niobium ID THERMOMECHANICAL CONTROL PROCESS; SERVICE LINE PIPE; MECHANICAL-PROPERTIES; LOW-CARBON; MICROALLOYED STEELS; TOUGHNESS; STRENGTH; NB; MO; PRECIPITATION AB The paper describes the concept of using low manganese content in pipeline steels for hydrogen-induced cracking (HIC) applications. The microstructure of thermomechanically processed pipeline steel primarily consisted of polygonal ferrite and low fraction of pearlite. The cleanliness of the steel was evident as was the absence of centerline segregation. The microstructure contained high dislocation density, sub-boundaries and dislocation substructures. Fine-scale precipitation of niobium carbides Occurred on parallel array of dislocations and on random dislocations that followed [0 0 1](NbC)//[0 0 1](alpha-Fe) relationship with the ferrite matrix. (C) 2008 Elsevier B.V. All rights reserved. C1 [Nayak, S. S.; Misra, R. D. K.] Univ Louisiana Lafayette, Ctr Struct & Funct Mat, Lafayette, LA 70504 USA. [Nayak, S. S.; Misra, R. D. K.] Univ Louisiana Lafayette, Dept Chem Engn, Lafayette, LA 70504 USA. [Hartmann, J.] USA, Arcelor Mittal Steel, Res & Dev, E Chicago, IN 46312 USA. [Siciliano, F.] CBMM, BR-38183970 Araxa, MG, Brazil. [Gray, J. M.] EWI Microalloying Int, Houston, TX 77036 USA. RP Misra, RDK (reprint author), Univ Louisiana Lafayette, Ctr Struct & Funct Mat, Madison Hall Room 217,POB 44130, Lafayette, LA 70504 USA. EM dmisra@louisiana.edu RI Nayak, Sashank/D-9835-2012 OI Nayak, Sashank/0000-0001-9679-2476 NR 27 TC 32 Z9 44 U1 2 U2 17 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 25 PY 2008 VL 494 IS 1-2 SI SI BP 456 EP 463 DI 10.1016/j.msea.2008.04.038 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 359JU UT WOS:000259983700064 ER PT J AU Li, HY Xu, LL Masuda, K Raymundo, E Mcleod, DG Dobi, A Srivastava, S AF Li, Hongyun Xu, Linda L. Masuda, Katsuaki Raymundo, Eliza Mcleod, David G. Dobi, Albert Srivastava, Shiv TI A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID LIGASE NEDD4; TUMOR SUPPRESSION; UBIQUITIN LIGASE; HOMEOBOX GENE; WW DOMAINS; EXPRESSION; GROWTH; NKX3.1; PTEN; DIFFERENTIATION AB PMEPA1 was identified originally as a highly androgen-inducible gene with prostate-abundant expression that was restricted to prostatic epithelial cells. PMEPA1 protein is a NEDD4 (ubiquitin-protein isopeptide ligase)-binding protein, which negatively regulates prostate cancer cell growth. In this study we establish that PMEPA1 is a direct transcriptional target of the androgen receptor (AR). We also demonstrate that PMEPA1 negatively regulates AR protein levels in different cell culture models. Transient expression of PMEPA1 down-regulates AR protein levels and AR transcriptional targets in prostate cancer cells. Conversely, knockdown of PMEPA1 leads to elevated levels of AR protein, AR transcriptional targets (prostate-specific antigen), and increased cell cycle S phase. We define that the PMEPA1-dependent down-regulation of AR is because of AR ubiquitination and proteasome-mediated degradation. The mutant PMEPA1 (PY1/2 motif mutation) that is impaired in NEDD4 recruitment shows attenuated AR ubiquitination and AR protein down-regulation. These data support the hypothesis that PMEPA1 negatively regulates the stability of AR protein by enhancing AR ubiquitination and proteasome-mediated degradation through NEDD4. The effect of PMEPA1 on AR ubiquitination and degradation appears to be MDM2-independent. Thus, the PMEPA1-AR degradation pathway may represent a new androgen-dependent mechanism for regulating AR levels in prostate epithelial cells. These findings underscore that the decreased PMEPA1 expression frequently noted in prostate cancers may lead to increased AR functions and strengthen the biological role of PMEPA1 in prostate cancers. C1 [Li, Hongyun; Xu, Linda L.; Masuda, Katsuaki; Raymundo, Eliza; Mcleod, David G.; Dobi, Albert; Srivastava, Shiv] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. [Mcleod, David G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Mcleod, David G.; Dobi, Albert; Srivastava, Shiv] Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. RP Dobi, A (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. EM adobi@cpdr.org; ssrivastava@cpdr.org FU National Institutes of Health (NCI) [1R01CA106653]; Center for Prostate Disease Research Program [HU001-04-C-1502] FX This work was supported, in whole or in part, by National Institutes of Health Grant 1R01CA106653 (NCI) (to S. S. and A. D.). This work was also supported by the Center for Prostate Disease Research Program through the Henry M. Jackson Foundation for the Advancement of Military Medicine under Contract HU001-04-C-1502 (2004) with the Uniformed Services University. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. Section 1734 solely to indicate this fact. NR 44 TC 35 Z9 37 U1 0 U2 6 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD OCT 24 PY 2008 VL 283 IS 43 BP 28988 EP 28995 DI 10.1074/jbc.M710528200 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 362EB UT WOS:000260179900024 PM 18703514 ER PT J AU Gillespie, K Kodani, I Dickinson, DP Ogbureke, KUE Camba, AM Wu, MJ Looney, S Chu, TC Qin, HY Bisch, F Sharawy, M Schuster, GS Hsu, SD AF Gillespie, Kevin Kodani, Isamu Dickinson, Douglas P. Ogbureke, Kalu U. E. Camba, Amy M. Wu, Mengjie Looney, Stephen Chu, Tin-Chun Qin, Haiyan Bisch, Frederick Sharawy, Mohamed Schuster, George S. Hsu, Stephen D. TI Effects of oral consumption of the green tea polyphenol EGCG in a murine model for human Sjogren's syndrome, an autoimmune disease SO LIFE SCIENCES LA English DT Article DE Sjogren's syndrome; Green tea; EGCG; Autoimmune disease; Non-obese diabetic mice ID SALIVARY-GLAND; CELLS; PATHOGENESIS; EXPRESSION; THERAPIES AB Significance: Protection of glandular cells from autoimmune-induced damage would be of significant clinical benefit to Sjogren's syndrome (SS) patients. Epigallocatechin-3-gallate (EGCG) possesses anti-apoptotic, anti-inflammatory, and autoantigen-inhibitory properties. Aims: To investigate if EGCG protects against certain autoimmune-induced pathological changes in the salivary glands of the non-obese diabetic (NOD) mouse model for SS. Main methods: Animals were provided with either water or water containing 0.2% EGCG. At the age of 8,16 and 22 weeks, submandibular salivary gland tissue and serum samples were collected for pathological and serological analysis. Key findings: Significant lymphocyte infiltration was observed in the salivary glands of the water-fed group at the age of 16 weeks, while the EGCG group showed reduced lymphocyte infiltration. By 22 weeks of age, water-fed animals demonstrated elevated levels of apoptotic activity within the lymphocytic infiltrates, and high levels of serum total anti-nuclear antibody, compared to EGCG-fed animals. Remarkably, proliferating cell nuclear antigen (PCNA) and Ki-67 levels in the salivary glands of water-fed NOD mice were significantly elevated in comparison to BALB/c control mice; in contrast, PCNA and Ki-67 levels in EGCC-fed NOD animals were similar to BALB/c mice. These results indicate that EGCG protects the NOD mouse submandibular glands from autoimmune-induced inflammation, and reduces serum autoantibody levels. Abnormal proliferation, rather than apoptosis, appears to be a characteristic of the NOD mouse gland that is normalized by EGCG. The evidence suggests that EGCG could be useful in delaying or managing SS-like autoimmune disorders. (C) 2008 Elsevier Inc. All rights reserved. C1 [Dickinson, Douglas P.; Ogbureke, Kalu U. E.; Camba, Amy M.; Looney, Stephen; Qin, Haiyan; Sharawy, Mohamed; Schuster, George S.; Hsu, Stephen D.] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA. [Gillespie, Kevin; Bisch, Frederick] USA, Dept Periodontol, Ft Gordon, GA USA. [Kodani, Isamu] Tottori Univ, Fac Med, Tottori Univ Hosp, Dept Oral & Maxillofacial Surg, Yonago, Tottori 683, Japan. [Wu, Mengjie] Zhejiang Univ, Sch Dent, Hosp Stomotol, Hangzhou 310003, Zhejiang, Peoples R China. [Chu, Tin-Chun] Seton Hall Univ, Coll Arts & Sci, Dept Biol Sci, S Orange, NJ USA. [Hsu, Stephen D.] US Dept Vet Affairs, VA Med Ctr, Augusta, GA USA. RP Hsu, SD (reprint author), Med Coll Georgia, Sch Dent, Dept Oral Biol, AD1443, Augusta, GA 30912 USA. EM shsu@mail.mcg.edu RI Dickinson, Douglas/B-9111-2009; OI Chu, Tinchun/0000-0002-6314-1009 FU MCG; US Army Periodontics; Department of Oral Biology; School of Dentistry FX The authors thank Ms. Vera B. Larke for her technical assistance. This study was supported in part by funds from a grant from MCG, a fund from US Army Periodontics, and from Department of Oral Biology, School of Dentistry to S.H. NR 28 TC 34 Z9 37 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0024-3205 J9 LIFE SCI JI Life Sci. PD OCT 24 PY 2008 VL 83 IS 17-18 BP 581 EP 588 DI 10.1016/j.lfs.2008.08.011 PG 8 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 365JJ UT WOS:000260401700001 PM 18809413 ER PT J AU Churaman, W Currano, L Singh, AK Rai, US Dubey, M Amirtharaj, P Ray, PC AF Churaman, Wayne Currano, Luke Singh, Anant Kumar Rai, Uma Shankar Dubey, Madan Amirtharaj, Paul Ray, Paresh Chandra TI Understanding the high energetic behavior of nano-energetic porous silicon SO CHEMICAL PHYSICS LETTERS LA English DT Article ID AB-INITIO; OXIDATION AB Nano-energetic materials have recently become a subject of intense interest due to improved performance in terms of energy release, ignition, and mechanical properties. Here we report the mechanism of highly energetic behavior of nano-crystalline porous silicon. We show that the nanocomposite reacts at lower temperatures than that required for the dehydration of NaClO4 center dot 1H(2)O by itself. Using time-resolved emission during energetic reaction and infrared absorption analysis after explosion, we demonstrated the formation of O and OH radicals during the explosion. A detailed chemical mechanism for the formation of O and OH radicals is presented based on QRRK estimates. (C) 2008 Elsevier B.V. All rights reserved. C1 [Singh, Anant Kumar; Rai, Uma Shankar; Ray, Paresh Chandra] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. [Churaman, Wayne; Currano, Luke; Dubey, Madan; Amirtharaj, Paul] USA, Res Lab, Adelphi, MD 20783 USA. RP Ray, PC (reprint author), Jackson State Univ, Dept Chem, Jackson, MS 39217 USA. EM paresh.c.ray@jsums.edu FU ARL [W911NF-06-1-0512] FX Dr. Ray thanks ARL Grant No. W911NF-06-1-0512 for their generous funding. We also thank reviewers whose valuable suggestion improved the quality of the manuscript. NR 16 TC 17 Z9 21 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD OCT 23 PY 2008 VL 464 IS 4-6 BP 198 EP 201 DI 10.1016/j.cplett.2008.09.017 PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 363HS UT WOS:000260259000014 ER PT J AU Lee, MS Olson, MA AF Lee, Michael S. Olson, Mark A. TI Calculation of Absolute Ligand Binding Free Energy to a Ribosome-Targeting Protein as a Function of Solvent Model SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID RICIN A-CHAIN; MOLECULAR-DYNAMICS SIMULATIONS; GENERALIZED BORN; CONTINUUM SOLVENT; AFFINITIES; SURFACE; INHIBITOR; ACCURATE; STREPTAVIDIN; ASSOCIATION AB A comparative analysis is provided of the effect of different solvent models on the calculation of a potential of mean force (PMF) for determining the absolute binding affinity of the small molecule inhibitor pteroic acid bound to ricin toxin A-chain (RTA). Solvent models include the distance-dependent dielectric constant, several different generalized Born (GB) approximations, and a hybrid explicit/GB-based implicit solvent model. We found that the simpler approximation of dielectric screening and a GB model, with Born radii fitted to a switching-window dielectric-boundary surface Poisson solvent model, severely overpredicted the binding affinity as compared to the experimental value, estimated to range from -4.4 to -6.0 kcal/mol. In contrast, GB models that are parametrized to fit the Lee-Richards molecular surface performed much better, predicting binding free energy within 1-3 kcal/mol of experimental estimates. However, the predicted free-energy profiles of these GB models displayed alternative binding modes not observed in the crystal structure. Finally, the most rigorous and computationally costly approach in this work, which used a hybrid explicit/implicit solvent model, correctly determined a binding funnel in the PMF near the crystallographic bound state and predicted an absolute binding affinity that was 2 kcal/mol more favorable than the estimated experimental binding affinity. C1 [Lee, Michael S.] USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. [Olson, Mark A.] USA, Med Res Inst Infect Dis, Dept Cell Biol & Biochem, Frederick, MD 21702 USA. RP Lee, MS (reprint author), USA, Res Lab, Computat Sci & Engn Branch, Aberdeen Proving Ground, MD 21005 USA. EM michael.lee@amedd.army.mil; molson@ncifcrf.gov FU Defense Threat Reduction Agency [3.10010_06_RD_B] FX We thank Drs. S. Zhang. X. Jiang, and J. Carra for helpful discussions. This work was funded by the Defense Threat Reduction Agency (Grant 3.10010_06_RD_B to MAO). Computational time was provided, in part, by the U.S. Anny Research Laboratory Major Shared Resource Center. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or of the U.S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 53 TC 12 Z9 12 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD OCT 23 PY 2008 VL 112 IS 42 BP 13411 EP 13417 DI 10.1021/jp802460p PG 7 WC Chemistry, Physical SC Chemistry GA 361AW UT WOS:000260100900034 PM 18821791 ER PT J AU Satya, RV Zavaljevski, N Kumar, K Bode, E Padilla, S Wasieloski, L Geyer, J Reifman, J AF Satya, Ravi Vijaya Zavaljevski, Nela Kumar, Kamal Bode, Elizabeth Padilla, Susana Wasieloski, Leonard Geyer, Jeanne Reifman, Jaques TI In silico microarray probe design for diagnosis of multiple pathogens SO BMC GENOMICS LA English DT Article ID OLIGONUCLEOTIDE; IDENTIFICATION; CRITERIA; ALIGNMENT; GENOMES; ASSAYS AB Background: With multiple strains of various pathogens being sequenced, it is necessary to develop high-throughput methods that can simultaneously process multiple bacterial or viral genomes to find common fingerprints as well as fingerprints that are unique to each individual genome. We present algorithmic enhancements to an existing single-genome pipeline that allows for efficient design of microarray probes common to groups of target genomes. The enhanced pipeline takes advantage of the similarities in the input genomes to narrow the search to short, nonredundant regions of the target genomes and, thereby, significantly reduces the computation time. The pipeline also computes a three-state hybridization matrix, which gives the expected hybridization of each probe with each target. Results: Design of microarray probes for eight pathogenic Burkholderia genomes shows that the multiple-genome pipeline is nearly four-times faster than the single-genome pipeline for this application. The probes designed for these eight genomes were experimentally tested with one non-target and three target genomes. Hybridization experiments show that less than 10% of the designed probes cross hybridize with non-targets. Also, more than 65% of the probes designed to identify all Burkholderia mallei and B. pseudomallei strains successfully hybridize with a B. pseudomallei strain not used for probe design. Conclusion: The savings in runtime suggest that the enhanced pipeline can be used to design fingerprints for tens or even hundreds of related genomes in a single run. Hybridization results with an unsequenced B. pseudomallei strain indicate that the designed probes might be useful in identifying unsequenced strains of B. mallei and B. pseudomallei. C1 [Satya, Ravi Vijaya; Zavaljevski, Nela; Kumar, Kamal; Reifman, Jaques] USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. [Bode, Elizabeth; Padilla, Susana; Wasieloski, Leonard; Geyer, Jeanne] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Biotechnol HPC Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. EM rvijaya@bioanalysis.org; nelaz@bioanalysis.org; kamal@bioanalysis.org; Elizabeth.Ardis.Bode@us.army.mil; Susana.Lopez2@amedd.army.mil; leonard.wasieloski@us.army.mil; jeanne.geyer@us.army.mil; jaques.reifman@us.army.mil OI Kumar, Kamal/0000-0002-9470-6682 FU U.S. Department of Defense High Performance Computing Modernization Program; U.S. Defense Threat Reduction Agency [8.10006 07 RD B] FX This work was sponsored by the U.S. Department of Defense High Performance Computing Modernization Program, under the High Performance Computing Software Applications Institutes initiative, and the U. S. Defense Threat Reduction Agency project 8.10006 07 RD B.; The opinions and assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U. S. Army or of the U. S. Department of Defense. This paper has been approved for public release with unlimited distribution. NR 25 TC 7 Z9 7 U1 1 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2164 J9 BMC GENOMICS JI BMC Genomics PD OCT 21 PY 2008 VL 9 AR 496 DI 10.1186/1471-2164-9-496 PG 11 WC Biotechnology & Applied Microbiology; Genetics & Heredity SC Biotechnology & Applied Microbiology; Genetics & Heredity GA 382LX UT WOS:000261608600001 ER PT J AU Wilber, DH Ray, GL Clarke, DG Diaz, RJ AF Wilber, D. H. Ray, G. L. Clarke, D. G. Diaz, R. J. TI Responses of Benthic Infauna to Large-Scale Sediment Disturbance in Corpus Christi Bay, Texas SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE Impact assessment; Recovery; Secondary production ID DREDGED MATERIAL DISPOSAL; SECONDARY PRODUCTION; COMMUNITIES; IMPACTS; HABITAT; USA; MACROINVERTEBRATES; RECOLONIZATION; CONSEQUENCES; MACROBENTHOS AB Responses of benthic infauna to large scale disturbance by dredged material placement were studied at eight paired (placement and reference) areas in Corpus Christi Bay, Texas in 1995 and 1996. Total infaunal abundance, taxa richness, and the biomass of annelids and molluscs in placement areas no longer differed from that of reference areas approximately one year after placement. Annual secondary production for annelids and molluscs did not differ between placement and reference areas, however mean ( standard error) total annual secondary production at reference areas (53.6 +/- 5.8 g AFDW/m(2)/yr) was greater than that of placement areas (26.2 2.5 g AFDW/M2 /yr) due to higher brittle star densities in reference areas. Differences in community structure between placement and reference areas returned to pre-placement levels one year after disturbance. The magnitude of changes in sediment grain size related to disturbance was positively correlated with the degree of convergence of placement area communities with pre-placement and reference communities. Sediment compaction was consistently associated with infaunal taxonomic composition (BIOENV) and increased linearly with time after disturbance. The use of the term "recovery" with reference to recolonization of dredging-related disturbance implies a return to pre-placement ecological conditions that are frequently neither a reality nor a practical expectation for areas that are subject to repeated disturbances. Our characterization of biological responses to dredged material disturbance targeted benchmarks that were linked to both pre-disturbance conditions and differences between disturbed and neighboring undisturbed areas and indicate that impacts persisted less than one year. (C) 2008 Published by Elsevier B.V. C1 [Ray, G. L.; Clarke, D. G.] USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wilber, D. H.] Bowhead Informat Technol Serv, Charleston, SC 29412 USA. [Diaz, R. J.] Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA. RP Clarke, DG (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Douglas.G.Clarke@erdc.usace.army.mil RI Langhamer, Olivia/J-3425-2012 NR 47 TC 9 Z9 9 U1 0 U2 12 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD OCT 20 PY 2008 VL 365 IS 1 BP 13 EP 22 DI 10.1016/j.jembe.2008.07.029 PG 10 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 367PN UT WOS:000260564300002 ER PT J AU Zuo, QH Rice, JR AF Zuo, Q. H. Rice, Jeremy R. TI An implicit algorithm for a rate-dependent ductile failure model SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HIGH-STRAIN-RATE; VOID NUCLEATION; FRACTURE; LOCALIZATION; DEFORMATION; PLASTICITY; STRESS; METALS; INTEGRATION; SURFACE AB An implicit numerical algorithm has been developed for a rate-dependent model for damage and failure of ductile materials under high-rate dynamic loading [F. L. Addessio and J. N. Johnson, J. Appl. Phys. 74, 1640 (1993)]. Over each time step, the algorithm first implicitly determines the equilibrium state on a Gurson surface, and then calculates the final state by solving viscous relaxation equations, also implicitly. Numerical examples are given to demonstrate the key features of the algorithm. Compared to the explicit algorithm used previously, the current algorithm allows significantly larger time steps that can be used in the analysis. As the viscosity of the material vanishes, the results of the rate-dependent model are shown here to converge to that of the corresponding rate-independent model, a result not achieved with the explicit algorithm. (c) 2008 American Institute of Physics. [DOI: 10.1063/1.3005883] C1 [Zuo, Q. H.; Rice, Jeremy R.] Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. [Rice, Jeremy R.] USA, Propuls & Struct Directorate, Res Dev & Engn Command, Redstone Arsenal, AL 35898 USA. RP Zuo, QH (reprint author), Univ Alabama, Dept Mech & Aerosp Engn, Huntsville, AL 35899 USA. EM zuo@eng.uah.edu FU joint Department of Energy (DOE); Department of Defense (DoD); Munitions Technology Development Program; DOE Advanced Simulation and Computing (ASC) Program; University of Alabama in Huntsville; Naval Surface Warfare Center Dahlgren Division (NSWC); Army Research, Development, and Engineering Command (ARDEC) FX This work was supported by the joint Department of Energy (DOE) and Department of Defense (DoD) Munitions Technology Development Program, the DOE Advanced Simulation and Computing (ASC) Program, a research startup fund from the University of Alabama in Huntsville, Naval Surface Warfare Center Dahlgren Division (NSWC), and Army Research, Development, and Engineering Command (ARDEC). The authors are grateful to F. L. Addessio, P. J. Maudlin, and J. N. Johnson for their encouragements and guidance. The comments by J. K. Dienes, R. M. Hackett and an anonymous reviewer were very helpful in the revision of the paper. Technical discussions with C. A. Bronkhorst, T. Canfield, E. N. Harstad, K. S. Holian, T. A. Mason, H. L. Schreyer, and M. Zocher were also very helpful. NR 32 TC 3 Z9 3 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 2008 VL 104 IS 8 AR 083526 DI 10.1063/1.3005883 PG 9 WC Physics, Applied SC Physics GA 367SG UT WOS:000260572100043 ER PT J AU Ouma, C Davenport, GC Awandare, GA Keller, CC Were, T Otieno, MF Vulule, JM Martinson, J Ong'echa, JM Ferrell, RE Perkins, DJ AF Ouma, Collins Davenport, Gregory C. Awandare, Gordon A. Keller, Christopher C. Were, Tom Otieno, Michael F. Vulule, John M. Martinson, Jeremy Ong'echa, John M. Ferrell, Robert E. Perkins, Douglas J. TI Polymorphic variability in the interleukin (IL)-1 beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1 beta production SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 55th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene CY NOV 11-16, 2006 CL Atlanta, GA SP Amer Soc Trop Med & Hyg ID PLASMODIUM-FALCIPARUM MALARIA; TUMOR-NECROSIS-FACTOR; MIGRATION INHIBITORY FACTOR; HIGH-DENSITY PARASITEMIA; FACTOR-ALPHA; RECEPTOR ANTAGONIST; ADHESION MOLECULES; CEREBRAL-MALARIA; YOUNG-CHILDREN; ENDEMIC AREAS AB Interleukin (IL)-1 beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1 beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1 beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level < 6.0 g/dL), and circulating IL-1 beta levels were investigated in children with parasitemia (n = 566) from western Kenya. The IL-1 beta promoter haplotype -31C/-511A ( CA) was associated with increased risk of SMA (Hb level < 6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P <. 05) and reduced circulating IL-1 beta levels (P <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA ( OR, 0.52 [95% CI, 0.18-1.16]; P=.11) and elevated IL-1 beta production (P <.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1 beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1 beta. The results presented demonstrate that variation in IL-1 beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1 beta levels. C1 [Perkins, Douglas J.] Univ New Mexico, Div Infect Dis, Sch Med, Albuquerque, NM 87131 USA. [Ouma, Collins; Were, Tom; Ong'echa, John M.; Perkins, Douglas J.] Univ New Mexico, Kenya Med Res Inst, Labs Parasit & Viral Dis, Kisumu, Kenya. [Vulule, John M.] Ctr Global Hlth Res, Kenya Med Res Inst, Kisumu, Kenya. [Ouma, Collins; Otieno, Michael F.] Kenyatta Univ, Dept Preclin Sci, Nairobi, Kenya. [Were, Tom] Kenyatta Univ, Dept Pathol, Nairobi, Kenya. [Davenport, Gregory C.; Awandare, Gordon A.; Keller, Christopher C.; Martinson, Jeremy] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Infect Dis & Microbiol, Pittsburgh, PA USA. [Ferrell, Robert E.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA USA. [Keller, Christopher C.] Lake Erie Coll Osteopath Med, Lab Human Pathogens, Erie, PA USA. [Awandare, Gordon A.] Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. [Ong'echa, John M.; Perkins, Douglas J.] Univ New Mexico, Sch Med, Div Infect Dis, Albuquerque, NM 87131 USA. RP Perkins, DJ (reprint author), Univ New Mexico, Div Infect Dis, Sch Med, MSC10-5550, Albuquerque, NM 87131 USA. EM dperkins@salud.unm.edu OI Martinson, Jeremy/0000-0003-4673-7238 FU FIC NIH HHS [D43 TW005884-06, D43 TW005884, TW05884-02]; NIAID NIH HHS [AI51305-02, T32 AI007538, R01 AI051305-06, R01 AI051305] NR 50 TC 20 Z9 20 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT 15 PY 2008 VL 198 IS 8 BP 1219 EP 1226 DI 10.1086/592055 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 358BQ UT WOS:000259891800019 PM 18781863 ER PT J AU Luo, N Miley, GH Mather, J Burton, R Hawkins, G Byrd, E Holcomb, F Rusek, J AF Luo, Nie Miley, G. H. Mather, Joseph Burton, Rodney Hawkins, G. Byrd, Ethan Holcomb, F. Rusek, J. TI Engineering of the bipolar stack of a direct NaBH4 fuel cell SO JOURNAL OF POWER SOURCES LA English DT Article DE Fuel cell; Sodium borohydride; Peroxide; Manifold; Short circuit ID OXIDATION; METHANOL AB When a fuel cell (FC) utilizes liquid fuels directly, a few complications arise due to the conductance or the potential conductance of the fuel. Fuel cell stacks are typically designed in a bipolar fashion so that the voltage of individual cells can be added up in series to give an adequate and convenient output voltage. The conductivity of fuels brings about two risks if the bipolar stack is not properly designed and engineered. On one hand, the conductive liquid fuel may short circuit the neighboring cells of a bipolar FC stack with traditional integrated fuel manifolds. On the other hand, the conductive fuel may pass a high voltage to some parts of the cell through an ordinary manifold, causing excessive corrosion. These issues need to be addressed through a cell-isolation fuel distribution network (FDN). The function of such an FDN is to increase the shunting resistance of neighboring cells, so as to maintain a reasonable open circuit voltage. Also, the presence of a gas phase in the liquid fuel during cell operation affects fuel circulation and therefore needs to be considered in the FDN design. On the plus side, a liquid fuel, in contact with high surface area FC electrodes, functions as a super-capacitor, giving the FC an excellent pulse overload capacity. Also the fuel itself is a fair coolant, enabling high power density at minimal increase in stack weight. These considerations are applied to a kilowatt NaBH4/H2O2 fuel cell stack to generate the desired operational characteristics. (c) 2008 Elsevier B.V. All rights reserved. C1 [Luo, Nie; Miley, G. H.] Univ Illinois, Dept Nucl Engn, Urbana, IL 61801 USA. [Mather, Joseph] Univ Illinois, Dept Mech Engn, Urbana, IL 61801 USA. [Burton, Rodney; Hawkins, G.] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA. [Byrd, Ethan] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA. [Holcomb, F.] USA Corps Engineer, CERL, Champaign, IL 61822 USA. [Rusek, J.] Swift Enterprises Ltd, W Lafayette, IN 47906 USA. RP Luo, N (reprint author), Univ Illinois, Dept Nucl Engn, 104 S Wright, Urbana, IL 61801 USA. EM nluo@uiuc.edu FU NASA [NNC05CB04C] FX The authors thank NPL Associates, Inc. for tremendous support on starting the peroxide fuel cell research. We are also indebted to Ji Cui (Nalco), Bill Saylor (SAIC) and Mike Obal (DARPA) for stimulating discussions. The work reported here was largely supported by NASA NNC05CB04C. Follow-on studies were supported by DARPA and Sandia National Laboratories. NR 15 TC 17 Z9 17 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD OCT 15 PY 2008 VL 185 IS 1 BP 356 EP 362 DI 10.1016/j.jpowsour.2008.06.051 PG 7 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA 358HB UT WOS:000259906600049 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Bitter Road to Freedom: A New History of the Liberation of Europe SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 80 EP 81 PG 2 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100172 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Brady's Civil War SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100170 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Faces of the Confederacy: An Album of Southern Soldiers and Their Stories SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100171 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The War Chronicles: From Chariots to Flintlocks; New Perspectives on the Two Thousand Years of Bloodshed That Shaped the Modern World SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100168 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Home Fronts: A Wartime America Reader SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100169 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Art of Command; Military Leadership from George Washington to Colin Powell SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 80 EP 80 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100167 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Danger's Hour: The Story of the USS Bunker Hill and the Kamikaze Pilot Who Crippled Her. S. & S. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100174 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI With Wings Like Eagles: A History of the Battle of Britain SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100175 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Baghdad at Sunrise: A Brigade Commander's War in Iraq. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100180 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Sheriff of Ramadi: Navy Seals and the Winning of al-Anbar. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100179 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The World at War: The Landmark Oral History SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100173 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Brenner Assignment: The Untold Story of the Most Daring Spy Mission of World War II. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100176 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The Last Stand of Fox Company: A True Story of US Marines in Combat. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100177 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Save the Last Bullet for Yourself: A Soldier of Fortune in the Balkans and Somalia. SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] CARL, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), CARL, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 15 PY 2008 VL 133 IS 17 BP 81 EP 81 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 363XP UT WOS:000260301100178 ER PT J AU Wei, Q Schuster, BE Mathaudhu, SN Hartwig, KT Kecskes, LJ Dowding, RJ Ramesh, KT AF Wei, Q. Schuster, B. E. Mathaudhu, S. N. Hartwig, K. T. Kecskes, L. J. Dowding, R. J. Ramesh, K. T. TI Dynamic behaviors of body-centered cubic metals with ultrafine grained and nanocrystalline microstructures SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article; Proceedings Paper CT Symposium on Mechanical Behavior of Nanostructured Materials held TMS 2007 Annual Meeting CY FEB 26-MAR 01, 2007 CL Orlando, FL SP TSM DE ultrafine grained metals; nanocrystalline metals; dynamic behavior ID SEVERE PLASTIC-DEFORMATION; MECHANICAL-PROPERTIES; SHEAR LOCALIZATION; RATE SENSITIVITY; STAINLESS-STEEL; COMPRESSION; TUNGSTEN; IRON; EVOLUTION; STRENGTH AB We have investigated the dynamic mechanical behaviors of representative body-centered cubic (b.c.c.) refractory metals with ultrafine grained (UFG, grain size (d) smaller than 500 nm, but larger than 100 nm) and nanocrystalline (NC, d smaller than 100 nm) microstructures. The UFG/NC microstructures were produced by either bottom-up or top-down fabrication. The dynamic compressive behavior was evaluated by means of uniaxial high strain rate Kolsky bar tests. For some of the metals, due to the special technique used for their fabrication, the specimen dimensions were very small. Therefore, a miniaturized desk-top Kolsky bar system was used to measure the dynamic behavior. Our experimental results indicate that the majority of the UFG/NC b.c.c. metals are prone to localized plastic flow under uni-axial dynamic compression, with UFG-Ta being an exception. This tendency is a consequence of the combined effect of reduced strain hardening capacity and strain rate sensitivity (SRS), increased yield strength, and enhanced adiabatic heating. The experimental observations are discussed in connection with mechanics-based models. (c) 2007 Elsevier B.V. All rights reserved. C1 [Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Wei, Q.; Ramesh, K. T.] Johns Hopkins Univ, Ctr Adv Ceram & Metall Syst, Baltimore, MD 21218 USA. [Schuster, B. E.; Mathaudhu, S. N.; Kecskes, L. J.; Dowding, R. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Hartwig, K. T.] Texas A&M Univ, Dept Mech Engn, College Stn, TX 77843 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn & Engn Sci, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Mathaudhu, Suveen/B-4192-2009; Kecskes, Laszlo/F-6880-2014; Dowding, Robert/F-1469-2015 OI Kecskes, Laszlo/0000-0002-1342-3729; Dowding, Robert/0000-0002-4763-2131 NR 37 TC 24 Z9 24 U1 1 U2 13 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD OCT 15 PY 2008 VL 493 IS 1-2 SI SI BP 58 EP 64 DI 10.1016/j.msea.2007.05.126 PG 7 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 357KN UT WOS:000259844800010 ER PT J AU Naumann, JC Anderson, JE Young, DR AF Naumann, Julie C. Anderson, John E. Young, Donald R. TI Linking physiological responses, chlorophyll fluorescence and hyperspectral imagery to detect salinity stress using the physiological reflectance index in the coastal shrub, Myrica cerifera SO REMOTE SENSING OF ENVIRONMENT LA English DT Article DE PRI; chlorophyll fluorescence; photosynthesis; salinity; airborne; hyperspectral reflectance ID SPACEBORNE IMAGING SPECTROSCOPY; LIGHT-USE EFFICIENCY; PLANT WATER STATUS; SPECTRAL REFLECTANCE; XANTHOPHYLL CYCLE; BARRIER-ISLAND; STEADY-STATE; PHOTOSYNTHETIC EFFICIENCY; SUNFLOWER LEAVES; DROUGHT STRESS AB Measurements of physiology, chlorophyll fluorescence and hyperspectral reflectance were used to detect salinity stress in the evergreen coastal shrub, Myrica cerifera on Hog Island, Virginia. Two experimental sites were used in our study, the oceanside of a M. cerifera thicket, which is exposed to sea spray, and the protected, leeside of the thicket. Using the physiological reflectance index (PRI), we were able to detect stress at both the canopy and landscape level. Monthly variations in stomatal conductance, photosynthesis, and relative water content indicated a strong summer drought response that was not apparent in chlorophyll fluorescence or in the water band index (WBI) derived from canopy and airborne reflectance measurements. In contrast, there were significant differences in both physiological measurements and tissue chlorides between the two sites used in the study, indicating salinity stress. This was reflected in measurements of PRI. There was a positive relationship between PRI measured at the canopy-level and light-adapted fluorescence (Delta F/F'(m),: r(2) = 0.69). PRI was significantly lower on the oceanside of the Myrica cerifera thicket. PRI was not significantly related to NDVI (r(2)=0.01) at the canopy-level and only weakly related (r(2)=0.04) at the landscape-level, suggesting that the indices are independent. The chlorophyll index (CI) did not show any significant changes between the two sites. Frequency histograms of pixels sampled from airborne hyperspectral imagery revealed that the distribution of PRI was shifted to the right on the backside of the thicket relative to the oecanside and there was a significant difference between sites. These results suggest that PRI may be used for early identification of salt-stress and to identify areas across the landscape where community structure may change due to sea-level rise. (c) 2008 Elsevier Inc. All rights reserved. C1 [Naumann, Julie C.; Young, Donald R.] Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. [Anderson, John E.] USA, Erdc, Fluorescence Spect Lab, Alexandria, VA 22315 USA. RP Young, DR (reprint author), Virginia Commonwealth Univ, Dept Biol, Richmond, VA 23284 USA. EM dryoung@vcu.edu NR 58 TC 28 Z9 32 U1 2 U2 17 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD OCT 15 PY 2008 VL 112 IS 10 BP 3865 EP 3875 DI 10.1016/j.rse.2008.06.004 PG 11 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA 356SO UT WOS:000259798100011 ER PT J AU Walker, MJ Boyles, RE Young, BA Strunce, JB Garber, MB Whitman, JM Deyle, G Wainner, RS AF Walker, Michael J. Boyles, Robert E. Young, Brian A. Strunce, Joseph B. Garber, Matthew B. Whitman, Julie M. Deyle, Gail Wainner, Robert S. TI The Effectiveness of Manual Physical Therapy and Exercise for Mechanical Neck Pain A Randomized Clinical Trial SO SPINE LA English DT Article DE mechanical neck pain; cervical pain; radicular pain; radiculitis; manual therapy; manipulation; mobilization; exercise ID LOW-BACK-PAIN; BETWEEN-SESSION CHANGES; SPINAL MANIPULATION; CERVICAL-SPINE; GENERAL-PRACTITIONER; PROGNOSTIC-FACTORS; PREDICTION RULE; CONTINUED CARE; MOBILIZATION; RELIABILITY AB Study Design. Randomized clinical trial. Objective. To assess the effectiveness of manual physical therapy and exercise (MTE) for mechanical neck pain with or without unilateral upper extremity (UE) symptoms, as compared to a minimal intervention (MIN) approach. Summary of Background Data. Mounting evidence supports the use of manual therapy and exercise for mechanical neck pain, but no studies have directly assessed its effectiveness for UE symptoms. Methods. A total of 94 patients referred to 3 physical therapy clinics with a primary complaint of mechanical neck pain, with or without unilateral UE symptoms, were randomized to receive MTE or a MIN approach of advice, motion exercise, and subtherapeutic ultrasound. Primary outcomes were the neck disability index, cervical and UE pain visual analog scales (VAS), and patient-perceived global rating of change assessed at 3-, 6-, and 52-weeks. Secondary measures included treatment success rates and post-treatment healthcare utilization. Results. The MTE group demonstrated significantly larger reductions in short- and long-term neck disability index scores (mean 1-year difference -5.1, 95% confidence intervals (CI) -8.1 to -2.1; P = 0.001) and short-term cervical VAS scores (mean 6- week difference -14.2, 95% CI -22.7 to -5.6; P = 0.001) as compared to the MIN group. The MTE group also demonstrated significant within group reductions in short- and long-term UE VAS scores at all time periods (mean 1-year difference -16.3, 95% CI - 23.1 to -9.5; P = 0.000). At 1-year, patient perceived treatment success was reported by 62% (29 of 47) of the MTE group and 32% (15 of 47) of the MIN group (P = 0.004). Conclusion. An impairment-based MTE program resulted in clinically and statistically significant short- and long-term improvements in pain, disability, and patient-perceived recovery in patients with mechanical neck pain when compared to a program comprising advice, a mobility exercise, and subtherapeutic ultrasound. C1 [Walker, Michael J.] Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. [Boyles, Robert E.] Univ Puget Sound, Sch Phys Therapy, Tacoma, WA 98416 USA. [Young, Brian A.] Dept Med Therapy, Sheppard AFB, TX USA. [Garber, Matthew B.] Blanchfield Army Community Hosp, Dept Phys Therapy, Ft Campbell, KY USA. [Whitman, Julie M.] Regis Univ, Dept Phys Therapy, RHSHP, Denver, CO USA. [Deyle, Gail] Baylor Univ, USA, Postprofess Doctoral Program Orthopaed Manual Phy, Ft Sam Houston, TX USA. [Wainner, Robert S.] SW Texas State Univ, Dept Phys Therapy, San Marcos, TX 78666 USA. RP Walker, MJ (reprint author), 418 Dickman Rd, San Antonio, TX 78234 USA. EM mwalker21@satx.rr.com NR 48 TC 43 Z9 43 U1 3 U2 20 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0362-2436 EI 1528-1159 J9 SPINE JI SPINE PD OCT 15 PY 2008 VL 33 IS 22 BP 2371 EP 2378 DI 10.1097/BRS.0b013e318183391e PG 8 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 361FK UT WOS:000260112700001 PM 18923311 ER PT J AU Felt, DR Bednar, AJ Georgian, T AF Felt, Deborah R. Bednar, Anthony J. Georgian, Thomas TI The effects of grinding methods on metals concentrations in soil SO TALANTA LA English DT Article DE Homogenization; Extraction efficiency; Grinding methods; Variability; Metals analysis; Sample preparation AB Multi-increment sampling (MI5) has been most extensively used for munitions constituents at environmental sites where a high degree of contaminant heterogeneity exits. A revised method (USEPA Method 833013) for explosives that uses MIS was announced in the fall of 2006, but similar guidance has not been reported for testing metals in soils. Questions have been raised as how to prepare representative analytical samples for metals determination from field composites. Three different grinding procedures were used in this study for three soil types to determine if grinding (relative to homogenizing soil without grinding) increases metal concentrations and decreases variability. The performance of these procedures was demonstrated via the analysis of replicates (n = 16 for two soil types) using statistical evaluations that included calculations of various descriptive statistics (e.g., medians, means and standard deviations), Kruskal-Wallis (KW) tests for the medians and two tests for the variances (Bartlett's and Levene's test). There was a slight increase in concentrations for several of the metals in the clay loam soil after grinding, although the increases were a small percentage of the concentrations measured. The standard deviations (and variances) for replicate digestions and analyses generally decreased, although anomalies were observed. The grinding methods increased precision overall, however, the data indicated that the roller mill grinding was not as effective as the other grinding methods tested. Published by Elsevier B.V. C1 [Felt, Deborah R.; Bednar, Anthony J.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Georgian, Thomas] USA, Environm & Munit Ctr Expertise, Omaha, NE 68102 USA. RP Felt, DR (reprint author), USA, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Deborah.Felt@usace.army.mil NR 19 TC 10 Z9 10 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD OCT 15 PY 2008 VL 77 IS 1 BP 380 EP 387 DI 10.1016/j.talanta.2008.06.039 PG 8 WC Chemistry, Analytical SC Chemistry GA 363TR UT WOS:000260290200059 PM 18804649 ER PT J AU Ellsworth, RE Ellsworth, DL Patney, HL Deyarmin, B Love, B Hooke, JA Shriver, CD AF Ellsworth, Rachel E. Ellsworth, Darrell L. Patney, Heather L. Deyarmin, Brenda Love, Brad Hooke, Jeffrey A. Shriver, Craig D. TI Amplification of HER2 is a marker for global genomic instability SO BMC CANCER LA English DT Article ID METASTATIC BREAST-CANCER; TRASTUZUMAB RESISTANCE; MONOCLONAL-ANTIBODY; GENETIC ALTERATIONS; CDNA MICROARRAYS; OVARIAN-CANCER; EXPRESSION; CHEMOTHERAPY; TUMORS; DNA AB Background: Genomic alterations of the proto-oncogene c-erbB-2 (HER-2/neu) are associated with aggressive behavior and poor prognosis in patients with breast cancer. The variable clinical outcomes seen in patients with similar HER2 status, given similar treatments, suggests that the effects of amplification of HER2 can be influenced by other genetic changes. To assess the broader genomic implications of structural changes at the HER2 locus, we investigated relationships between genomic instability and HER2 status in patients with invasive breast cancer. Methods: HER2 status was determined using the PathVysion (R) assay. DNA was extracted after laser microdissection from the 181 paraffin-embedded HER2 amplified (n = 39) or HER2 negative (n = 142) tumor specimens with sufficient tumor available to perform molecular analysis. Allelic imbalance (AI) was assessed using a panel of microsatellite markers representing 26 chromosomal regions commonly altered in breast cancer. Student t-test and partial correlations were used to investigate relationships between genomic instability and HER2 status. Results: The frequency of AI was significantly higher (P < 0.005) in HER2 amplified (27%) compared to HER2 negative tumors (19%). Samples with HER2 amplified showed significantly higher levels of AI (P < 0.05) at chromosomes 11q23, 16q22-q24 and 18q21. Partial correlations including ER status and tumor grade supported associations between HER2 status and alterations at 11q13.1, 16q22-q24 and 18q21. Conclusion: The poor prognosis associated with HER2 amplification may be attribute to global genomic instability as cells with high frequencies of chromosomal alterations have been associated with increased cellular proliferation and aggressive behavior. In addition, high levels of DNA damage may render tumor cells refractory to treatment. In addition, specific alterations at chromosomes 11q13, 16q22-q24, and 18q21, all of which have been associated with aggressive tumor behavior, may serve as genetic modifiers to HER2 amplification. These data not only improve our understanding of HER in breast pathogenesis but may allow more accurate risk profiles and better treatment options to be develop. C1 [Ellsworth, Rachel E.] Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Rockville, MD USA. [Ellsworth, Darrell L.; Patney, Heather L.; Deyarmin, Brenda] Windber Res Inst, Clin Breast Care Project, Windber, PA USA. [Love, Brad] Invitrogen, Carlsbad, CA USA. [Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. RP Ellsworth, RE (reprint author), Henry M Jackson Fdn Adv Mil Med, Clin Breast Care Project, Rockville, MD USA. EM r.ellsworth@wriwindber.org; d.ellsworth@wriwindber.org; h.patney@wriwindber.org; b.deyarmin@wriwindber.org; drblove@yahoo.com; jeffrey.hooke1@us.army.mil; craig.shriver@us.army.mil NR 36 TC 18 Z9 20 U1 0 U2 1 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2407 J9 BMC CANCER JI BMC Cancer PD OCT 14 PY 2008 VL 8 AR 297 DI 10.1186/1471-2407-8-297 PG 9 WC Oncology SC Oncology GA 368OK UT WOS:000260631300002 PM 18854030 ER PT J AU Dixon, WC Wang, TY Dai, D Shunk, KA Peterson, ED Roe, MT AF Dixon, William C. Wang, Tracy Y. Dai, David Shunk, Kendrick A. Peterson, Eric D. Roe, Matthew T. CA Natl Cardiovasc Data Registry TI Anatomic distribution of the culprit lesion in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention - Findings from the national cardiovascular data registry SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Letter ID WALL SHEAR-STRESS; ANGIOGRAPHY; VESSEL C1 [Dixon, William C.] Dwight D Eisenhower Army Med Ctr, Serv Cardiol, Ft Gordon, GA 30905 USA. RP Dixon, WC (reprint author), Dwight D Eisenhower Army Med Ctr, Serv Cardiol, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM william.dixon@amedd.army.mil NR 10 TC 21 Z9 21 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD OCT 14 PY 2008 VL 52 IS 16 BP 1347 EP 1348 DI 10.1016/j.jacc.2008.07.029 PG 2 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA 358BB UT WOS:000259890200010 PM 18929247 ER PT J AU Kerksick, C Harvey, T Stout, J Campbell, B Wilborn, C Kreider, R Kalman, D Ziegenfuss, T Lopez, H Landis, J Ivy, JL Antonio, J AF Kerksick, Chad Harvey, Travis Stout, Jeff Campbell, Bill Wilborn, Colin Kreider, Richard Kalman, Doug Ziegenfuss, Tim Lopez, Hector Landis, Jamie Ivy, John L. Antonio, Jose TI International Society of Sports Nutrition position stand: Nutrient timing (vol 5, pg 17, 2008) SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Correction C1 [Kerksick, Chad; Stout, Jeff] Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA. [Kerksick, Chad] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Endocrinol & Diabet Sect, Oklahoma City, OK 73104 USA. [Harvey, Travis] US Mil Acad, Ctr Phys Dev Excellence, Dept Phys Educ, West Point, NY 10996 USA. [Campbell, Bill] Univ S Florida, Sch Phys Educ & Exercise Sci, Tampa, FL 33620 USA. [Wilborn, Colin] Univ Mary Hardin Baylor, Dept Exercise & Sport Sci, Belton, TX 76513 USA. [Kreider, Richard] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA. [Kalman, Doug] Miami Res Associates, Div Nutr & Endocrinol, Miami, FL 33143 USA. [Ziegenfuss, Tim] Ctr Appl Hlth Sci, Div Sports Nutr & Exercise Sci, Fairlawn, OH 44333 USA. [Lopez, Hector] Northwestern Univ, Dept Phys Med & Rehabil, Feinberg Sch Med, Chicago, IL 60611 USA. [Landis, Jamie] Lakeland Community Coll, Dept Biol, Kirtland, OH 44094 USA. [Ivy, John L.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Antonio, Jose] Nova SE Univ, Farquhar Coll Arts & Sci, Ft Lauderdale, FL 33314 USA. RP Kerksick, C (reprint author), Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA. EM Chad_Kerksick@ou.edu; Travis.Harvey@usma.edu; jrstout@ou.edu; Campbell@coedu.usf.edu; cwilborn@umhb.edu; rkreider@hlkn.tamu.edu; dkalman@miamiresearch.com; Tziegenfuss@wadsnet.com; hlopezmd@gmail.com; jlandis@lakelandcc.edu; johnivy@mail.utexas.edu; ja839@nova.edu RI Kerksick, Chad/G-9059-2013; Stout, Jeffrey/F-5805-2014; Kreider, Richard/O-1804-2014 OI Kerksick, Chad/0000-0003-0458-7294; Kreider, Richard/0000-0002-3906-1658 NR 1 TC 4 Z9 4 U1 1 U2 8 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD OCT 14 PY 2008 VL 5 AR 18 DI 10.1186/1550-2783-5-18 PG 1 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 487NJ UT WOS:000269281100001 ER PT J AU Huang, HC Pan, YL Hill, SC Pinnick, RG Chang, RK AF Huang, Hermes C. Pan, Yong-Le Hill, Steven C. Pinnick, Ronald G. Chang, Richard K. TI Real-time measurement of dual-wavelength laser-induced fluorescence spectra of individual aerosol particles SO OPTICS EXPRESS LA English DT Article ID BIOLOGICAL PARTICLES; BIOAEROSOLS; POLLUTION; CLOUDS; SENSOR; HEALTH AB We report the development of an in-situ aerosol detection system capable of rapidly measuring dual-wavelength laser-induced fluorescence spectra of single particles on the fly using a single spectrometer and a single 32-anode photomultiplier array. We demonstrate the capability of this system with both reference samples and outdoor air. We present spectra from separate excitation wavelengths from the same particle that demonstrate improved discrimination capability compared with only using one excitation wavelength. (C) 2008 Optical Society of America C1 [Huang, Hermes C.; Pan, Yong-Le; Chang, Richard K.] Yale Univ, Dept Appl Phys, New Haven, CT 06511 USA. [Hill, Steven C.; Pinnick, Ronald G.] USA, Res Lab, Adelphi, MD 20783 USA. RP Huang, HC (reprint author), Yale Univ, Dept Appl Phys, 15 Prospect St, New Haven, CT 06511 USA. EM Hermes.Huang@yale.edu FU Defense Threat Reduction Agency; ARL mission funds; National Defense Science and Engineering FX This research was supported by the Defense Threat Reduction Agency under the Physical Science and Technology Basic Research Program, by ARL mission funds, and by a National Defense Science and Engineering Graduate fellowship to H. Huang (through ASEE). John Bowersett (ARL) machined the double nozzle assembly. We thank Yale's Chemical Engineering Department for providing the room used for ambient air sampling. NR 15 TC 18 Z9 19 U1 0 U2 16 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD OCT 13 PY 2008 VL 16 IS 21 BP 16523 EP 16528 DI 10.1364/OE.16.016523 PG 6 WC Optics SC Optics GA 371XB UT WOS:000260864900027 PM 18852760 ER PT J AU Opsenica, I Opsenica, D Lanteri, CA Anova, L Milhous, WK Smith, KS Solaja, BA AF Opsenica, Igor Opsenica, Dejan Lanteri, Charlotte Anne Anova, Lalaine Milhous, Wilbur K. Smith, Kirsten S. Solaja, Bogdan A. TI New chimeric antimalarials with 4-aminoquinoline moiety linked to a tetraoxane skeleton SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ACID-DERIVATIVES; DISPIRO-1,2,4,5-TETRAOXANES; 1,2,4,5-TETRAOXANES; STABILITY; MOLECULES; HYBRID; DRUGS AB The synthesis of the chimeric molecules consisting of two pharmacophores, tetraoxane and 7-chloro-4-aminoquinoline, is reported. The tetraoxanes 2, 4, and 8 show relatively potent in vitro antimalarial activities, with IC90 values for the Plasmodium falciparum strain W2 of 2.26, 12.44, and 10.74 nM, respectively. In addition, two compounds, 2 and 4, cured mice in a modified Thompson test for antimalarial blood stage activity, with a minimum curative dose of 80 mg/kg, a minimum active dose of 20 mg/kg/day, and a maximum tolerated dose of > 960 mg/kg. C1 [Solaja, Bogdan A.] Univ Belgrade, Fac Chem, Belgrade 11001, Serbia. [Opsenica, Igor; Opsenica, Dejan] Inst Chem Technol & Met, Belgrade, Serbia. [Lanteri, Charlotte Anne; Anova, Lalaine; Milhous, Wilbur K.; Smith, Kirsten S.] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 158, Belgrade 11001, Serbia. EM bsolaja@chem.bg.ac.yu RI Opsenica, Igor/P-5308-2016; OI Opsenica, Igor/0000-0003-4942-4042; Solaja, Bogdan/0000-0002-9975-2725 FU Ministry of Science of Serbia [142022]; Serbian Academy of Sciences and Arts.; U.S. National Institute of Allergy and Infectious Diseases FX This work has been supported by the Ministry of Science of Serbia (grant no. 142022) and the Serbian Academy of Sciences and Arts. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. We thank Lucia Gerena, of the Walter Reed Army Institute of Research, for performing and providing results from the in vitro antimalarial assay. We also thank Dr. Montip Gettayacamin, of AFRIMS, for executing and providing results from mouse malaria efficacy screening. Material has been reviewed by the Walter Reed Army Institute of Research, and there is no objection to its presentation or publication. The opinions or assertions contained herein are the private true views of the Department of the Army or the Department of Defense. BA. is indebted to Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) for providing anti mycobacterial and cytotoxicity data through a research and development contract with the U.S. National Institute of Allergy and Infectious Diseases. NR 32 TC 39 Z9 40 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD OCT 9 PY 2008 VL 51 IS 19 BP 6216 EP 6219 DI 10.1021/jm8006905 PG 4 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 356EC UT WOS:000259760500040 PM 18774792 ER PT J AU Zuniga, JE Schmidt, JJ Fenn, T Burnett, JC Arac, D Gussio, R Stafford, RG Badie, SS Bavari, S Brunger, AT AF Zuniga, Jorge E. Schmidt, James J. Fenn, Timothy Burnett, James C. Arac, Demet Gussio, Rick Stafford, Robert G. Badie, Shirin S. Bavari, Sina Brunger, Axel T. TI A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate SO STRUCTURE LA English DT Article ID LIGHT-CHAIN; NEUROTRANSMITTER RELEASE; RESOLUTION AB Botulinum neurotoxin serotype A is the most lethal of all known toxins. Here, we report the crystal structure, along with SAR data, of the zinc metalloprotease domain of BoNT/A bound to a potent peptidomimetic inhibitor (K-i = 41 nM) that resembles the local sequence of the SNAP-25 substrate. Surprisingly, the inhibitor adopts a helical conformation around the cleavage site, in contrast to the extended conformation of the native substrate. The backbone of the inhibitor's P1 residue displaces the putative catalytic water molecule and concomitantly interacts with the "proton shuttle" E224. This mechanism of inhibition is aided by residue contacts in the conserved S1' pocket of the substrate binding cleft and by the induction of new hydrophobic pockets, which are not present in the apo form, especially for the P2' residue of the inhibitor. Our inhibitor is specific for BoNT/A as it does not inhibit other BoNT serotypes orthermolysin. C1 [Zuniga, Jorge E.; Fenn, Timothy; Arac, Demet; Brunger, Axel T.] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Fenn, Timothy; Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Fenn, Timothy; Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Fenn, Timothy; Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Biol Struct, Stanford, CA 94305 USA. [Zuniga, Jorge E.; Fenn, Timothy; Arac, Demet; Brunger, Axel T.] Stanford Univ, Dept Photon Sci, Stanford, CA 94305 USA. [Schmidt, James J.; Stafford, Robert G.; Badie, Shirin S.; Bavari, Sina] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Burnett, James C.] SAIC Frederick Inc, Target Struct Based Drug Discovery Grp, Frederick, MD 21702 USA. [Gussio, Rick] NCI, Dev Therapeut Program, Frederick, MD 21702 USA. RP Brunger, AT (reprint author), Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA. EM brunger@stanford.edu OI Brunger, Axel/0000-0001-5121-2036 FU Department of Energy; National Institutes of Health [N01-CO-12400]; National Institute of General Medical Sciences; Department of Defense [3.1002406RDB]; Defense Threat Reduction Agency [3.1002307RDB]; National Cancer Institute; Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute FX SSRL is a national userfacility operated by Stanford University on behalf ofthe US Department of Energy (Office of Basic Energy Sciences). The SSRL Structural Molecular Biology Program is supported by the Department of Energy (Office of Biological and Environmental Research), and by the National Institutes of Health (National Center for Research Resources, Biomedical Technology Program), and the National Institute of General Medical Sciences. This work was supported by the Department of Defense (proposal number 3.1002406RDB to A.T.B.) and by the Defense Threat Reduction Agency (proposal number 3.1002307RDB to J.J.S.). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract . The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported in part by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. NR 24 TC 42 Z9 42 U1 0 U2 2 PU CELL PRESS PI CAMBRIDGE PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA SN 0969-2126 J9 STRUCTURE JI Structure PD OCT 8 PY 2008 VL 16 IS 10 BP 1588 EP 1597 DI 10.1016/j.str.2008.07.011 PG 10 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 358PU UT WOS:000259930800017 PM 18940613 ER PT J AU Eckart, RE Field, ME Hruczkowski, TW Forman, DE Dorbala, S Di Carli, MF Albert, CE Malsel, WH Epstein, LM Stevenson, WG AF Eckart, Robert E. Field, Michael E. Hruczkowski, Tomasz W. Forman, Daniel E. Dorbala, Sharmila Di Carli, Marcelo F. Albert, Christine E. Malsel, William H. Epstein, Laurence M. Stevenson, William G. TI Association of electrocardiographic morphology of exercise-induced ventricular arrhythmia with mortality SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID CORONARY-ARTERY-DISEASE; OUTFLOW TRACT TACHYCARDIA; PROGNOSTIC VALUE; BRUGADA-SYNDROME; 12-LEAD ELECTROCARDIOGRAM; FRAGMENTED-QRS; HEART; PREDICTOR; ORIGIN; SCORE AB Background: The prognostic importance of exercise-induced ventricular arrhythmia (EIVA) may be confounded by the presence of lower-risk idiopathic right ventricular outflow tract arrhythmias with left bundle-branch block (LBBB) morphology. Objective: To determine whether right bundle-branch block (RBBB)-morphology EIVA was associated with increased mortality. Design: Retrospective cohort. Setting: Academic medical center. Patients: 585 unique patients with EIVA and 2340 patients without EIVA, matched by age, sex, and risk factor, who were referred for exercise testing in an academic medical center. Measurements: Deaths and ischemia and infarction found on perfusion scan. Results: During a mean follow-up of 24 months (SD, 13), 31 deaths occurred in the EIVA group compared with 43 deaths in the group without EIVA (5.3% vs. 1.8%; P < 0.001). Worse survival in patients with RBBB-morphology or multiple-morphology EIVA (6.9%) than in patients without EIVA caused this difference. Patients with LBBB-morphology EIVAs had a mortality rate (2.5%) similar to that of patients without EIVA (P = 0.93, log-rank test). Among patients without known atherosclerotic coronary artery disease, any RBBB-morphology EIVA was associated with death (hazard ratio, 2.73 [95% CI, 1.78 to 4.13]; P < 0.001), but LBBB-morphology EIVA was not (hazard ratio, 0.82 [CI, 0.18 to 2.04]; P = 0.72). Limitations: Not all LBBB-morphology EIVA can be dismissed, and not all RBBB-morphology EIVA is high risk. Further evaluation of patients for structural heart disease was clinically driven, not protocol-driven. Conclusion: Right bundle-branch block-or multiple-morphology EIVA is associated with increased mortality. Inclusion of patients with isolated LBBB-morphology EIVA, which often is idiopathic, may contribute to differences in the prognostic importance of EIVA in previous studies. C1 [Eckart, Robert E.] Brooke Army Med Ctr, Arrhythmia Serv ATTN MCHE MDC, San Antonio, TX 78234 USA. Brigham & Womens Hosp, Boston Vet Adm Med Ctr, Boston, MA 02115 USA. Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. Univ Alberta, Edmonton, AB, Canada. RP Eckart, RE (reprint author), Brooke Army Med Ctr, Arrhythmia Serv ATTN MCHE MDC, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA. EM robert.eckart@us.army.mil FU Medtronic; Boston Scientific; Biosense Webster FX Honoraria: L. M. Epstein (Medtronic, Boston Scientific, St. Jude). Grants received: L. M. Epstein (Medtronic, Boston Scientific, Biosense Webster). NR 31 TC 8 Z9 10 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD OCT 7 PY 2008 VL 149 IS 7 BP 451 EP W82 PG 11 WC Medicine, General & Internal SC General & Internal Medicine GA 359QY UT WOS:000260004400002 PM 18838725 ER PT J AU Wang, H Munger, KL Reindl, M O'Reilly, EJ Levin, LI Berger, T Ascherio, A AF Wang, H. Munger, K. L. Reindl, M. O'Reilly, E. J. Levin, L. I. Berger, T. Ascherio, A. TI Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults SO NEUROLOGY LA English DT Article ID ANTIMYELIN ANTIBODIES; DEMYELINATING EVENT; ENCEPHALOMYELITIS; IDENTIFICATION; INFLAMMATION; PROGRESSION; MARKERS; RISK; RAT; MOG AB Background: It remains uncertain whether the presence of serum anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in healthy individuals contributes to predict their risk of developing multiple sclerosis (MS). Methods: Prospective, nested case-control study of more than 7 million US military personnel who have serum samples stored in the Department of Defense Serum Repository. A total of 126 MS cases and 252 controls matched by age, sex, race/ethnicity, and dates of blood collection were included in the analysis. An ELISA was used to detect IgM and IgG antibodies to MOG. Analyses were conducted with and without adjustment for serum titers of antibodies to the Epstein-Barr nuclear antigen (EBNA), which are an established risk factor for MS. Results: The presence of anti-MOG IgG antibodies in serum was associated with an increase in risk of developing MS (relative risk for anti-MOG IgG+/IgM - vs seronegativity to both anti-MOG IgM and IgG: 2.03; 95% CI: 1.19-3.46; p = 0.01). This association, however, was attenuated and no longer significant after adjustment for titers of antibodies to EBNA, which were higher among individuals positive for anti-MOG antibodies. Conclusion: Our findings suggest that although individuals with anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have an increased risk of developing multiple sclerosis, this association may at least in part reflect cross-reactivity between MOG and Epstein-Barr nuclear antigen. C1 [Wang, H.; Munger, K. L.; O'Reilly, E. J.; Ascherio, A.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Ascherio, A.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. [Ascherio, A.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Reindl, M.; Berger, T.] Innsbruck Med Univ, Dept Clin Neurol, Innsbruck, Austria. [Levin, L. I.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD USA. RP Wang, H (reprint author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA. EM hwang@hsph.harvard.edu NR 24 TC 31 Z9 32 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD OCT 7 PY 2008 VL 71 IS 15 BP 1142 EP 1146 DI 10.1212/01.wnl.0000316195.52001.e1 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA 356XE UT WOS:000259810100004 PM 18753473 ER PT J AU Schiltz, H Chung, MK Lee, SJ Gagne, MR AF Schiltz, Holly Chung, Mee-Kyung Lee, Stephen J. Gagne, Michel R. TI The effect of gas-phase reactions on the quantitation of cyclic hydrazone libraries by electrospray ionization (ESI) mass spectrometry SO ORGANIC & BIOMOLECULAR CHEMISTRY LA English DT Article ID DYNAMIC COMBINATORIAL CHEMISTRY; AMPLIFICATION; DISCOVERY AB Using mass spectrometry coupled with LC analysis we report evidence of diastereomer dependent fragmentation and oligomerization reactions in the ionization of acyl-hydrazone-based libraries of cyclic oligomers. These effects can significantly affect the accuracy of MS-based quantitations, but also provide a venue for examining ionization effects in dynamic combinatorial libraries (DCLs). C1 [Schiltz, Holly; Chung, Mee-Kyung; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM Stephen.Lee2@us.army.mil; mgagne@umc.edu FU Department of Education; Army Research Office [W911NF04D0004]; Defense Threat Reduction Agency (DTRA) [W911NF04D0004] FX HS thanks the Department of Education for a GAANN Fellowship, SJL thanks the Army Research Office (W911NF04D0004), and MRG thanks the Defense Threat Reduction Agency (DTRA) for support (W911NF04D0004). We also acknowledge helpful discussions with Profs Marcey L. Waters and James W. Jorgenson (UNC Chapel Hill). NR 14 TC 7 Z9 7 U1 0 U2 5 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1477-0520 J9 ORG BIOMOL CHEM JI Org. Biomol. Chem. PD OCT 7 PY 2008 VL 6 IS 19 BP 3597 EP 3600 DI 10.1039/b808490d PG 4 WC Chemistry, Organic SC Chemistry GA 356YL UT WOS:000259813400019 PM 19082161 ER PT J AU Kerksick, C Harvey, T Stout, J Campbell, B Wilborn, C Kreider, R Kalman, D Ziegenfuss, T Lopez, H Landis, J Ivy, JL Antonio, J AF Kerksick, Chad Harvey, Travis Stout, Jeff Campbell, Bill Wilborn, Colin Kreider, Richard Kalman, Doug Ziegenfuss, Tim Lopez, Hector Landis, Jamie Ivy, John L. Antonio, Jose TI International Society of Sports Nutrition position stand: Nutrient timing SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION LA English DT Review ID CARBOHYDRATE-PROTEIN SUPPLEMENT; AMINO-ACID INGESTION; MUSCLE GLYCOGEN USE; PREEXERCISE GLUCOSE-INGESTION; PROLONGED CYCLING EXERCISE; RESISTANCE EXERCISE; ENDURANCE PERFORMANCE; GLYCEMIC INDEX; HORMONAL RESPONSE; RUNNING CAPACITY AB Position Statement: The position of the Society regarding nutrient timing and the intake of carbohydrates, proteins, and fats in reference to healthy, exercising individuals is summarized by the following eight points: 1.) Maximal endogenous glycogen stores are best promoted by following a high-glycemic, high-carbohydrate (CHO) diet (600 - 1000 grams CHO or similar to 8 - 10 g CHO/kg/d), and ingestion of free amino acids and protein ( PRO) alone or in combination with CHO before resistance exercise can maximally stimulate protein synthesis. 2.) During exercise, CHO should be consumed at a rate of 30 - 60 grams of CHO/hour in a 6 - 8% CHO solution ( 8 - 16 fluid ounces) every 10 - 15 minutes. Adding PRO to create a CHO: PRO ratio of 3 - 4: 1 may increase endurance performance and maximally promotes glycogen re-synthesis during acute and subsequent bouts of endurance exercise. 3.) Ingesting CHO alone or in combination with PRO during resistance exercise increases muscle glycogen, offsets muscle damage, and facilitates greater training adaptations after either acute or prolonged periods of supplementation with resistance training. 4.) Post-exercise (within 30 minutes) consumption of CHO at high dosages (8 - 10 g CHO/kg/day) have been shown to stimulate muscle glycogen re-synthesis, while adding PRO (0.2 g - 0.5 g PRO/kg/day) to CHO at a ratio of 3 - 4: 1 (CHO: PRO) may further enhance glycogen re-synthesis. 5.) Post-exercise ingestion (immediately to 3 h post) of amino acids, primarily essential amino acids, has been shown to stimulate robust increases in muscle protein synthesis, while the addition of CHO may stimulate even greater levels of protein synthesis. Additionally, pre-exercise consumption of a CHO + PRO supplement may result in peak levels of protein synthesis. 6.) During consistent, prolonged resistance training, post-exercise consumption of varying doses of CHO + PRO supplements in varying dosages have been shown to stimulate improvements in strength and body composition when compared to control or placebo conditions. 7.) The addition of creatine (Cr) (0.1 g Cr/kg/day) to a CHO + PRO supplement may facilitate even greater adaptations to resistance training. 8.) Nutrient timing incorporates the use of methodical planning and eating of whole foods, nutrients extracted from food, and other sources. The timing of the energy intake and the ratio of certain ingested macronutrients are likely the attributes which allow for enhanced recovery and tissue repair following high-volume exercise, augmented muscle protein synthesis, and improved mood states when compared with unplanned or traditional strategies of nutrient intake. C1 [Kerksick, Chad; Stout, Jeff] Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA. [Kerksick, Chad] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Endocrinol & Diabet Sect, Oklahoma City, OK 73104 USA. [Harvey, Travis] US Mil Acad, Dept Phys Educ, Ctr Phys Dev Excellence, West Point, NY 10996 USA. [Campbell, Bill] Univ S Florida, Sch Phys Educ & Exercise Sci, Tampa, FL 33620 USA. [Wilborn, Colin] Univ Mary Hardin Baylor, Dept Exercise & Sport Sci, Belton, TX 76513 USA. [Kreider, Richard] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA. [Kalman, Doug] Miami Res Associates, Nutr Endocrinol Div, Miami, FL 33143 USA. [Ziegenfuss, Tim] Ctr Appl Hlth Sci, Div Sports Nutr & Exercise Sci, Fairlawn, OH 44333 USA. [Lopez, Hector] Northwestern Univ, Feinberg Sch Med, Dept Phys Med & Rehabil, Chicago, IL 60611 USA. [Landis, Jamie] Lakeland Community Coll, Dept Biol, Kirtland, OH 44094 USA. [Ivy, John L.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA. [Antonio, Jose] Nova SE Univ, Farquhar Coll Arts & Sci, Ft Lauderdale, FL 33314 USA. RP Kerksick, C (reprint author), Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA. EM Chad_Kerksick@ou.edu; Travis.Harvey@usma.edu; jrstout@ou.edu; Campbell@coedu.usf.edu; cwilborn@umhb.edu; rkreider@hlkn.tamu.edu; dkalman@miamiresearch.com; Tziegenfuss@wadsnet.com; hlopezmd@gmail.com; jlandis@lakelandcc.edu; johnivy@mail.utexas.edu; ja839@nova.edu RI Kerksick, Chad/G-9059-2013; Stout, Jeffrey/F-5805-2014; Kreider, Richard/O-1804-2014 OI Kerksick, Chad/0000-0003-0458-7294; Kreider, Richard/0000-0002-3906-1658 NR 102 TC 73 Z9 73 U1 5 U2 85 PU BIOMED CENTRAL LTD PI LONDON PA CURRENT SCIENCE GROUP, MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1550-2783 J9 J INT SOC SPORT NUTR JI J. Int. Soc. Sport Nutr. PD OCT 3 PY 2008 VL 5 AR 17 DI 10.1186/1550-2783-5-17 PG 12 WC Nutrition & Dietetics; Sport Sciences SC Nutrition & Dietetics; Sport Sciences GA 487NA UT WOS:000269280200002 PM 18834505 ER PT J AU Currano, LJ Bauman, S Churaman, W Peckerar, M Wienke, J Kim, S Yu, M Balachandran, B AF Currano, Luke J. Bauman, Scott Churaman, Wayne Peckerar, Marty Wienke, James Kim, Seokjin Yu, Miao Balachandran, Balakumar TI Latching ultra-low power MEMS shock sensors for acceleration monitoring SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article DE shock sensor; latching; low power; acceleration monitoring AB A microelectromechanical shock sensor, which uses a latching mechanism to record a shock event above a specified threshold level, is discussed in this article. The fabrication process for the shock sensor, which includes wafer-level vacuum packaging, is detailed along with the design features. These features include a reset actuator for reuse of the sensor, a no-power operation scheme when the reset actuator is not activated, and a control circuit to minimize power used to unlatch the sensor. In order to describe the shock-sensor dynamics and interaction with the latch mechanism, a preliminary non-linear model has been developed. Experimental results are presented and compared with model predictions. Published by Elsevier B.V. C1 [Currano, Luke J.] USA, Res Lab, Adelphi, MD 21046 USA. [Currano, Luke J.; Yu, Miao; Balachandran, Balakumar] Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. [Churaman, Wayne] Gen Tech Serv, Wall Township, NJ 07719 USA. RP Currano, LJ (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 21046 USA. EM lcurrano@arl.army.mil RI Yu, Miao/M-6252-2013 OI Yu, Miao/0000-0003-4180-5094 NR 9 TC 20 Z9 21 U1 1 U2 11 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD OCT 3 PY 2008 VL 147 IS 2 BP 490 EP 497 DI 10.1016/j.sna.2008.06.009 PG 8 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 355CC UT WOS:000259685600021 ER PT J AU Schuster, BE Wei, Q Hufnagel, TC Ramesh, KT AF Schuster, B. E. Wei, Q. Hufnagel, T. C. Ramesh, K. T. TI Size-independent strength and deformation mode in compression of a Pd-based metallic glass SO ACTA MATERIALIA LA English DT Article DE Metallic glasses; Mechanical properties; Ion beam processing; Nanoindentation; Size effects ID YIELD CRITERION; BULK; PD40NI40P20; BEHAVIOR; FLOW AB We present quasi-static, room temperature compression data for Pd40Ni40P20 metallic glasses, with specimen sizes ranging from the submicron to several millimeters in diameter. We observe no change in deformation mode over this range. At all sizes, plastic flow is localized in shear bands, which are accompanied by sudden strain bursts. This metallic glass shows only a modest increase in strength in going from bulk to micrometer-sized specimens. We show that stress gradients in tapered specimens can complicate measurement of the yield strength of metallic glasses in microcompression. Estimates of yield strength based on the minimum cross-sectional area implicitly assume that yielding is controlled by a maximum effective shear stress criterion. An alternative is the shear plane yield criterion, in which the minimum shear stress on the shear band trajectory determines yield. Application of this criterion in tapered microspecimens reinforces the notion that metallic glasses possess relatively size-independent mechanical properties. Published by Elsevier Ltd on behalf of Acta Materialia Inc. C1 [Schuster, B. E.] USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. [Schuster, B. E.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA. [Hufnagel, T. C.] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA. RP Schuster, BE (reprint author), USA, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM bschuster@arl.army.mil RI Wei, Qiuming/B-7579-2008; Hufnagel, Todd/A-3309-2010; Hasan, Molla/M-2465-2016 OI Hufnagel, Todd/0000-0002-6373-9377; Hasan, Molla/0000-0003-2409-7751 FU US Army Research Laboratory; Center for Advanced Metallic and Ceramic Systems (CAMCS) [DAAL01-96-2-0047]; ARMAC-RTP Cooperative Agreement [DAAD19-01-2-0003, W91INF-06-2-0006]; National Science Foundation [DMR-07505517] FX Research at the US Army Research Laboratory is supported through the Director's Research Initiative. This work was performed under the auspices of the Center for Advanced Metallic and Ceramic Systems (CAMCS) at The Johns Hopkins University through Grant No. DAAL01-96-2-0047 and ARMAC-RTP Cooperative Agreement Nos. DAAD19-01-2-0003 and W91INF-06-2-0006. T.C.H. additionally acknowledges support from the National Science Foundation under Grant DMR-07505517. The authors thank M.H. Ervin, S. Hruszkewycz and M.K. Miller for their early contributions to this work, M.D. Uchic for sharing his expert advice in microcompression fabrication techniques, and C.L. Chien and Q. Zhu for graciously sharing the focused ion beam facility at The Johns Hopkins University Materials Research Science and Engineering Center. NR 24 TC 122 Z9 125 U1 4 U2 68 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6454 J9 ACTA MATER JI Acta Mater. PD OCT PY 2008 VL 56 IS 18 BP 5091 EP 5100 DI 10.1016/j.actamat.2008.06.028 PG 10 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 369OP UT WOS:000260704100015 ER PT J AU Fuselier, EJ AF Fuselier, Edward J. TI Improved stability estimates and a characterization of the native space for matrix-valued RBFs SO ADVANCES IN COMPUTATIONAL MATHEMATICS LA English DT Article DE divergence-free; radial basis functions; stability; native spaces; interpolation ID RADIAL BASIS FUNCTIONS; SCATTERED-DATA; FUNCTION INTERPOLATION; INVERSES AB In this paper we derive several new results involving matrix-valued radial basis functions (RBFs). We begin by introducing a class of matrix-valued RBFs which can be used to construct interpolants that are curl-free. Next, we offer a characterization of the native space for divergence-free and curl-free kernels based on the Fourier transform. Finally, we investigate the stability of the interpolation matrix for both the divergence-free and curl-free cases, and when the kernel has finite smoothness we obtain sharp estimates. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Fuselier, EJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM edward.fuselier@usma.edu NR 16 TC 11 Z9 11 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1019-7168 J9 ADV COMPUT MATH JI Adv. Comput. Math. PD OCT PY 2008 VL 29 IS 3 BP 269 EP 290 DI 10.1007/s10444-007-9046-3 PG 22 WC Mathematics, Applied SC Mathematics GA 343DQ UT WOS:000258833300004 ER PT J AU Kozlowski, PA Oaks, EV Camp, JV Wilson, RL Nabel, GJ Rao, S Aldovini, A Singletary, M Blanchard, J AF Kozlowski, P. A. Oaks, E. V. Camp, J. V. Wilson, R. L. Nabel, G. J. Rao, S. Aldovini, A. Singletary, M. Blanchard, J. TI Invaplex: A Safe Nasal Adjuvant for Enhancing Mucosal and Systemic Antibody Responses to DNA/Protein Vaccines SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Kozlowski, P. A.; Camp, J. V.; Wilson, R. L.] LSU Hlth Sci Ctr, New Orleans, LA USA. [Oaks, E. V.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Nabel, G. J.; Rao, S.] NIAID, Vaccine Res Ctr, Bethesda, MD 20892 USA. [Aldovini, A.] Childrens Hosp, Boston, MA 02115 USA. [Singletary, M.; Blanchard, J.] Tulane Natl Primate Res Ctr, Covington, LA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 14 EP 15 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800033 ER PT J AU Bakari, M Mhalu, F Aboud, S Nilsson, C Francis, J Janabi, M Lyamuya, E Aris, EA Mbwana, J Buma, D Mwanyika, L Hejdeman, B Brave, A Robb, M Marovich, M Michael, N Earl, P Wahren, B Biberfeld, G Pallangyo, K Sandstrom, E AF Bakari, M. Mhalu, F. Aboud, S. Nilsson, C. Francis, J. Janabi, M. Lyamuya, E. Aris, E. A. Mbwana, J. Buma, D. Mwanyika, L. Hejdeman, B. Brave, A. Robb, M. Marovich, M. Michael, N. Earl, P. Wahren, B. Biberfeld, G. Pallangyo, K. Sandstrom, E. TI Safety and Immunogenicity of an HIV-1 DNA Plasmid Vaccine Boosted with HIV-1 MVA Among Police Officers (PO's) in Dar es Salaam, Tanzania SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Bakari, M.; Mhalu, F.; Aboud, S.; Lyamuya, E.; Mbwana, J.; Pallangyo, K.] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania. [Nilsson, C.; Brave, A.; Wahren, B.; Biberfeld, G.] Swedish Inst Infect Dis Control, Stockholm, Sweden. [Nilsson, C.; Brave, A.; Wahren, B.; Biberfeld, G.] Karolinska Inst, Stockholm, Sweden. [Francis, J.] Muhimbili Med Ctr, Natl Inst Med Res, Dar Es Salaam, Tanzania. [Janabi, M.; Aris, E. A.; Buma, D.] Muhmbili Natl Hosp, Dar Es Salaam, Tanzania. [Mwanyika, L.] Tanzania Police Force, Dar Es Salaam, Tanzania. [Hejdeman, B.] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden. [Robb, M.; Marovich, M.; Michael, N.] Walter Reed Army Inst Res, Rockville, MD USA. [Earl, P.] NIAID, NIH, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 17 EP 17 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800039 ER PT J AU Pitisttithum, P Rerks-Ngarm, S Kaewkungwal, J Nitayaphan, S Benenson, M Paris, R Michael, N Kim, J Khamboonruang, C Kunasol, P AF Pitisttithum, P. Rerks-Ngarm, S. Kaewkungwal, J. Nitayaphan, S. Benenson, M. Paris, R. Michael, N. Kim, J. Khamboonruang, C. Kunasol, P. CA MOPH-TAVEG TI The Follow-up Phase of the Phase III Community Trial: Current Activities SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Pitisttithum, P.; Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand. [Nitayaphan, S.; Benenson, M.; Paris, R.; Kim, J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. [Michael, N.; Kim, J.] Walter Reed Army Inst Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 18 EP 19 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800042 ER PT J AU Kulkarni, SS Lapedes, A Tang, H Gnanakaran, G Daniels, MG Zhang, M Li, M Polonis, VR McCutchan, FE Morris, L Ellenberger, D Butera, ST Bollinger, RC Korber, BT Paranjape, RS Montefiori, DC AF Kulkarni, S. S. Lapedes, A. Tang, H. Gnanakaran, G. Daniels, M. G. Zhang, M. Li, M. Polonis, V. R. McCutchan, F. E. Morris, L. Ellenberger, D. Butera, S. T. Bollinger, R. C. Korber, B. T. Paranjape, R. S. Montefiori, D. C. TI Highly Complex Neutralization Determinants on a Monophyletic Lineage of Newly Transmitted Subtype C HIV-1 Env Clones from India SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Kulkarni, S. S.; Paranjape, R. S.] Natl AIDS Res Inst, Pune, Maharashtra, India. [Lapedes, A.; Gnanakaran, G.; Daniels, M. G.; Zhang, M.; Korber, B. T.] Los Alamos Natl Lab, Los Alamos, NM USA. [Tang, H.; Li, M.; Montefiori, D. C.] Duke Univ, Med Ctr, Durham, NC USA. [Polonis, V. R.; McCutchan, F. E.; Bollinger, R. C.] Walter Reed Army Inst Res, Rockville, MD USA. [Morris, L.] Natl Inst Communicable Dis, Johannesburg, South Africa. [Ellenberger, D.; Butera, S. T.] Ctr Dis Control & Prevent, Atlanta, GA USA. Johns Hopkins Sch Med, Baltimore, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 48 EP 49 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800117 ER PT J AU Gudmundsdotter, L Nilsson, C Sandstrom, E Hejdeman, B Robb, M Marovich, M Michael, N Moss, B Earl, P Biberfeld, G Wahren, B AF Gudmundsdotter, L. Nilsson, C. Sandstrom, E. Hejdeman, B. Robb, M. Marovich, M. Michael, N. Moss, B. Earl, P. Biberfeld, G. Wahren, B. TI Expression of HIV-1 Genes from a Modified Vaccinia Ankara (MVA) Vector Overrides the Pre-Existing Vector Immunity in a Human Vaccine Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Gudmundsdotter, L.] Karolinska Inst, Stockholm, Sweden. [Nilsson, C.; Biberfeld, G.; Wahren, B.] Swedish Inst Infect Dis Control, Stockholm, Sweden. [Sandstrom, E.; Hejdeman, B.] Soder Sjukhuset, Stockholm, Sweden. [Robb, M.; Marovich, M.; Michael, N.] Walter Reed Army Inst Res, Rockville, MD USA. [Moss, B.; Earl, P.] NIAID, Bethesda, MD 20892 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 98 EP 98 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800248 ER PT J AU Rerks-Ngarm, S Pitisuttithum, P Nitayaphan, S Kim, J Kaewkungwal, J Gurunathan, S Gurwith, M Michael, N Khamboonruang, C Thongcharoen, P Kunasol, P AF Rerks-Ngarm, S. Pitisuttithum, P. Nitayaphan, S. Kim, J. Kaewkungwal, J. Gurunathan, S. Gurwith, M. Michael, N. Khamboonruang, C. Thongcharoen, P. Kunasol, P. TI Phase III Trial of HIV Prime-Boost Vaccine Combination in Thailand: Follow Up Phase SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Rerks-Ngarm, S.] Prime Boost HIV Vaccine Phase 3 Trial, Nonthaburi, Thailand. [Pitisuttithum, P.; Kaewkungwal, J.] Mahidol Univ, Fac Trop Med, Bangkok, Thailand. [Nitayaphan, S.; Kim, J.] Armed Forces Res Med Sci AFRIMS, Bangkok, Thailand. [Gurunathan, S.] Sanofi Pasteur, Swiftwater, PA USA. [Gurwith, M.] VaxGen Inc, Brisbane, Qld, Australia. [Michael, N.] Walter Reed Army Inst Res, Rockville, MD USA. [Khamboonruang, C.; Thongcharoen, P.; Kunasol, P.] MOPH, Dept Dis Control, Nonthaburi, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 101 EP 101 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800256 ER PT J AU Schuetz, A Haule, A Schunk, M Maboko, L Kroidl, A Hoelscher, M Marovich, M Robb, M Michael, N Graham, B Cox, J de Souza, M AF Schuetz, A. Haule, A. Schunk, M. Maboko, L. Kroidl, A. Hoelscher, M. Marovich, M. Robb, M. Michael, N. Graham, B. Cox, J. de Souza, M. TI Cellular Immune Responses Assessed by ICS and ELISpot in Volunteers Enrolled in a Phase I/II Multiclade HIV-1 DNA Plasmid/rAd5 Boost Vaccine Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Schuetz, A.; Marovich, M.; Robb, M.; Michael, N.; Cox, J.] USMHRP Henry M Jackson Fdn, Mbeya, Tanzania. [Haule, A.; Maboko, L.; Kroidl, A.] Mbeya Med Res Programme, Mbeya, Tanzania. [Schunk, M.; Hoelscher, M.] Univ Munich, Dept Infect Dis & Trop Med, Munich, Bavaria, Germany. [Graham, B.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [de Souza, M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 102 EP 102 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800258 ER PT J AU Eller, L Eller, M Naluyima, P Kyabaggu, D Wabwire-Mangen, F Marovich, M Cox, J Michael, N Graham, B Kibuuka, H Robb, M de Souza, M AF Eller, L. Eller, M. Naluyima, P. Kyabaggu, D. Wabwire-Mangen, F. Marovich, M. Cox, J. Michael, N. Graham, B. Kibuuka, H. Robb, M. de Souza, M. TI Cellular Immune Responses in Ugandan Volunteers Enrolled in a Phase 1 HIV-1 DNA (VRC-HIVDNA009-00-VP)/rAd5 (VRC-HIVADV014-00-VP) Boost Vaccine Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Eller, L.; Eller, M.; Marovich, M.; Cox, J.; Michael, N.; Robb, M.] Makerere Univ, Walter Reed Project, US Mil HIV Res Program, Kampala, Uganda. [Graham, B.; Kibuuka, H.] NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA. [de Souza, M.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 105 EP 105 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800266 ER PT J AU Luddaglom, J Suttijitjul, S Witayakom, B Premsri, N Debyasuvarn, T Sirijongdee, N Kim, JH Paris, R Rerks-Ngarm, S AF Luddaglom, J. Suttijitjul, S. Witayakom, B. Premsri, N. Debyasuvarn, T. Sirijongdee, N. Kim, J. H. Paris, R. Rerks-Ngarm, S. TI Psychological Status of Break-Through Infected Volunteer Participating in the Phase III HIV Vaccine Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Suttijitjul, S.; Witayakom, B.; Premsri, N.; Debyasuvarn, T.; Rerks-Ngarm, S.] Prime Boost HIV Vaccine Trial, Dept Dis Control, Nonthaburi, Thailand. [Sirijongdee, N.; Kim, J. H.; Paris, R.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 108 EP 109 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800275 ER PT J AU Suttijitju, S Witayakom, B Luddaglom, J Sirijongdee, N Premsri, N Debyasuvarn, T Kim, JH Paris, R Rerks-Ngarm, S AF Suttijitju, S. Witayakom, B. Luddaglom, J. Sirijongdee, N. Premsri, N. Debyasuvarn, T. Kim, J. H. Paris, R. Rerks-Ngarm, S. TI Factors Influenced Decision Making of HIV Infected Volunteers to Participate in the Long Term Follow Up Study; Prime-Boost HIV Vaccine Phase III Trial SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Suttijitju, S.; Witayakom, B.; Luddaglom, J.; Premsri, N.; Debyasuvarn, T.; Rerks-Ngarm, S.] Prime Boost HIV Vaccine Phase 3 Trial, Nonthaburi, Thailand. [Sirijongdee, N.; Kim, J. H.; Paris, R.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NR 0 TC 0 Z9 0 U1 1 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 109 EP 109 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800276 ER PT J AU Brown, B Lombardi, K Lindsay, W Jason, N Borges, AR Thelian, D Michael, N Currier, J McCutchan, F Montefiori, D Polonis, V AF Brown, B. Lombardi, K. Lindsay, W. Jason, N. Borges, A. Rosa Thelian, D. Michael, N. Currier, J. McCutchan, F. Montefiori, D. Polonis, V. TI Characterization of the Influence of PBMC Donor Parameters on HIV-1 PBMC Neutralization Assay Variability: Implications for Assay Standardization SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract CT AIDS Vaccine 2008 Conference CY OCT 13-16, 2008 CL Cape Town, SOUTH AFRICA SP NIAID, Div AIDS, NIH, Div AIDS C1 [Brown, B.; Lombardi, K.; Lindsay, W.; Jason, N.; Borges, A. Rosa; Thelian, D.; Currier, J.; McCutchan, F.] Henry M Jackson Fdn, Rockville, MD USA. [Michael, N.; Polonis, V.] Walter Reed Army Inst Res, Rockville, MD USA. [Montefiori, D.] Duke Univ, Raleigh, NC USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 2008 VL 24 BP 156 EP 156 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 367CT UT WOS:000260530800403 ER PT J AU Fadare, O Orejudos, MP Jain, R Mariappan, MR Hecht, JL Renshaw, IL Hileeto, D Wang, SA Ghofrani, M Liang, SX AF Fadare, Oluwole Orejudos, Michael P. Jain, Reena Mariappan, M. Rajan Hecht, Jonathan L. Renshaw, Idris L. Hileeto, Denise Wang, Sa A. Ghofrani, Mohiedean Liang, Sharon X. TI A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline turnors) with and without lymph node involvement SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Meeting Abstract CT Annual Meeting of the American-Society-of-Clinical-Pathology CY OCT 16-19, 2008 CL Baltimore, MD SP Amer Soc Clin Pathol C1 [Fadare, Oluwole; Orejudos, Michael P.] Wilford Hall USAF Med Ctr, Dept Pathol, San Antonio, TX 78236 USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Jain, Reena] Virginia Commonwealth Univ, Richmond, VA 23284 USA. [Mariappan, M. Rajan; Hecht, Jonathan L.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. [Mariappan, M. Rajan; Hecht, Jonathan L.] Harvard Univ, Sch Med, Boston, MA 02115 USA. [Hileeto, Denise] McMaster Univ, Hamilton, ON, Canada. [Wang, Sa A.] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA. [Ghofrani, Mohiedean] SW Washington Med Ctr, Vancouver, WA USA. [Liang, Sharon X.] SUNY Stony Brook, Med Ctr, Stony Brook, NY 11794 USA. [Orejudos, Michael P.] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA. [Orejudos, Michael P.] Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. [Orejudos, Michael P.] Brooke Army Med Ctr, Lab Serv, Ft Sam Houston, TX 78234 USA. [Renshaw, Idris L.] Vanguard Pathol Associates, Austin, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD OCT PY 2008 VL 130 IS 4 MA 43 BP 662 EP 662 PG 1 WC Pathology SC Pathology GA 349ZY UT WOS:000259323400066 ER PT J AU Comstock, GW AF Comstock, George W. TI MORTALITY OF PERSONS WITH PHOTOFLUOROGRAMS SUGGESTIVE OF CARDIOVASCULAR DISEASE (Reprinted from New England Journal of Medicine, vol 248, pg 1045-1050, 1953) SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Reprint C1 [Comstock, George W.] USA, Publ Hlth Serv, Atlanta, GA USA. RP Comstock, GW (reprint author), USA, Publ Hlth Serv, Atlanta, GA USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD OCT 1 PY 2008 VL 168 IS 7 BP 715 EP 732 DI 10.1093/aje/kwn324 PG 18 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 359DE UT WOS:000259965600011 PM 18820269 ER PT J AU Bredrup, C Matejas, V Barrow, M Blahova, K Bockenhauer, D Fowler, DJ Gregson, RM Maruniak-Chudek, I Medeira, A Mendonca, EL Kagan, M Koenig, J Krastel, H Kroes, HY Saggar, A Sawyer, T Schittkowski, M Swietlinski, J Thompson, D Vandevoorde, RG Wittebol-Post, D Woodruff, G Zurowska, A Hennekam, RC Zenker, M Russell-Eggitt, I AF Bredrup, Cecilie Matejas, Verena Barrow, Margaret Blahova, Kveta Bockenhauer, Detlef Fowler, Darren J. Gregson, Richard M. Maruniak-Chudek, Iwona Medeira, Ana Mendonca, Erica Laima Kagan, Mikhail Koenig, Jens Krastel, Hermann Kroes, Hester Y. Saggar, Anand Sawyer, Taylor Schittkowski, Michael Swietlinski, Janusz Thompson, Dorothy Vandevoorde, Rene G. Wittebol-Post, Dienke Woodruff, Geoffrey Zurowska, Aleksandra Hennekam, Raoul C. Zenker, Martin Russell-Eggitt, Isabelle TI Ophthalmological aspects of Pierson syndrome SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID CONGENITAL NEPHROSIS SYNDROME; DISTINCT EYE ABNORMALITIES; OCULAR ABNORMALITIES; MESANGIAL SCLEROSIS; LAMB2; MICROCORIA; MUTATIONS; BIRTH AB PURPOSE: To study the ocular phenotype of Pierson syndrome and to increase awareness among ophthalmologists of the diagnostic features of this condition. DESIGN: Retrospective, observational case series. METHODS: A multicenter study of 17 patients with molecularly confirmed Pierson syndrome. The eye findings were reviewed and compared to pertinent findings from the literature. RESULTS: The most characteristic ocular anomaly was microcoria. A wide range of additional abnormalities were found, including posterior embryotoxon, megalocornea, iris hypoplasia, cataract, abnormal lens shape, posterior lenticonus, persistent fetal vasculature, retinal detachment, variable axial lengths, and glaucoma. There was high interocular and intrafamilial variability. CONCLUSIONS: Loss-of-function mutations in laminin beta 2 (LAMB2) cause a broad range of ocular pathology, emphasizing the importance of laminin beta 2 in eye development. Patients with Pierson syndrome can initially present with ocular signs alone. In newborns with marked bilateral microcoria, Pierson syndrome should be considered and renal function investigated. C1 [Russell-Eggitt, Isabelle] Great Ormond St Hosp Sick Children, Dept Ophthalmol, London WC1N 3JH, England. [Bredrup, Cecilie] Haukeland Hosp, Dept Ophthalmol, N-5021 Bergen, Norway. [Bredrup, Cecilie] Univ Bergen, Dept Clin Med, Bergen, Norway. [Matejas, Verena; Zenker, Martin] Univ Erlangen Nurnberg, Inst Human Genet, Univ Hosp Erlangen, D-8520 Erlangen, Germany. [Barrow, Margaret; Woodruff, Geoffrey] Leicester Royal Infirm, Leicester, Leics, England. [Blahova, Kveta] Charles Univ Prague, Prague, Czech Republic. [Gregson, Richard M.] Queens Med Ctr, Nottingham NG7 2UH, England. [Maruniak-Chudek, Iwona] Med Univ Silesia, Katowice, Poland. [Medeira, Ana; Mendonca, Erica Laima] Hosp Santa Maria, Lisbon, Portugal. [Kagan, Mikhail] Orenburg Reg Childrens Hosp, Orenburg, Russia. [Koenig, Jens] Univ Childrens Hosp, Munster, Germany. [Krastel, Hermann] Univ Heidelberg, Dept Ophthalmol, D-6900 Heidelberg, Germany. [Kroes, Hester Y.; Wittebol-Post, Dienke] Univ Med Ctr Utrecht, Utrecht, Netherlands. [Saggar, Anand] Univ London St Georges Hosp, London, England. [Sawyer, Taylor] Tripler Army Med Ctr, Honolulu, HI 96859 USA. [Schittkowski, Michael] Univ Hosp Rostock, Rostock, Germany. [Swietlinski, Janusz] Childrens Mem Hlth Inst, Warsaw, Poland. [Vandevoorde, Rene G.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA. [Zurowska, Aleksandra] Univ Gdansk, Sch Med, Dept Pediat & Adolescent Nephrol & Hypertens, PL-80952 Gdansk, Poland. RP Russell-Eggitt, I (reprint author), Great Ormond St Hosp Sick Children, Dept Ophthalmol, Great Ormond St, London WC1N 3JH, England. EM eggiti@gosh.nhs.uk RI Bockenhauer, Detlef/C-5951-2008; Kagan, Mikhail/M-1110-2014 OI Bockenhauer, Detlef/0000-0001-5878-941X; Thompson, Dorothy/0000-0001-5491-3911; Kagan, Mikhail/0000-0002-7444-9885 FU GERMAN RESEARCH FOUNDATION (DFG) [ZE 524/3-1] FX THIS STUDY WAS SUPPORTED IN PART BY A GRANT FROM THE GERMAN RESEARCH FOUNDATION (DFG) TO DR ZENKER (ZE 524/3-1). The authors indicate no financial conflict of interest. Involved in design and conduct of study (C.B., M.B., K.B., D.B., R.M.G., I.M.C., A.M., E.L.M., J.K., H.K., H.Y.K., A.S., T.S., M.S., D.W.P., G.W., A.Z., R.C.H., M.Z., I.R.E.); collection, management, analysis, and interpretation of the data (C.B., V.M., M.B., K.B., D.B., D.J.F., R.M.G., I.M.C., A.M., E.L.M., M.K., J.K., H.K., H.Y.K., A.S., T.S., M.S., J.S., D.T., R.G.V., D.W.P., G.W., A.Z., R.C.H. M.Z., I.R.E.); preparation (C.B., R.C.H., M.Z., I.R.E.); review (C.B., V.M., M.B., K.B., D.B., D.J.F., R.M.G., I.M.C., A.M., E.L.M., M.K., J.K., FIX., H.Y.K., A.S., T.S., M.S., J.S., D.T., R.G.V., D.W.P., G.W., A.Z., R.C.H., M.Z., I.R.E.); and approval of the manuscript (C.B., V.M., M.B., K.B., D.B., D.J.F., R.M.G., I.M.C., A.M., E.L.M., M.K., J.K., H.K., H.Y.K., A.S., T.S., M.S., J.S., D.T., R.G.V., D.W.P., G.W., A.Z., R.C.H., M.Z., I.R.E.). Institutional Review Board approval (no. 3145) for molecular studies in Pierson syndrome has been obtained from the Ethics Committee University of Erlangen-Nuremberg (Genetic basis of syndromic forms of congenital nephrosis [Pierson syndrome, Galloway-Mowat syndrome]). Written informed consent was obtained from all parents for molecular testing of their offspring and transfer and analysis of clinical data. The views expressed in this :article are those of the authors and do nor reflect the official policy or position of the Department of the Army, Department of Defence, or the U.S. government. NR 20 TC 28 Z9 29 U1 0 U2 8 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD OCT PY 2008 VL 146 IS 4 BP 602 EP 611 DI 10.1016/j.ajo.2008.05.039 PG 10 WC Ophthalmology SC Ophthalmology GA 355XH UT WOS:000259742200020 PM 18672223 ER PT J AU Bryant, LR Song, WS Banks, KP Bui-Mansfield, LT Bradley, YC AF Bryant, L. Ray Song, Won S. Banks, Kevin P. Bui-Mansfield, Liem T. Bradley, Yong C. TI Comparison of Planar Scintigraphy Alone and with SPECT for the Initial Evaluation of Femoral Neck Stress Fracture SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article DE femoral neck; hip; nuclear medicine; planar scintigraphy; SPECT; sports medicine; stress fractures ID NEGATIVE BONE-SCAN AB OBJECTIVE. The objective of our study was to compare the accuracy of planar scintigraphy alone versus planar scintigraphy with SPECT for the initial evaluation of femoral neck stress fractures in a young military population. MATERIALS AND METHODS. We retrospectively identified 38 patients who had undergone planar scintigraphy and 33 patients who had undergone planar scintigraphy and SPECT before MRI of the hips over a 6-month period for evaluation of suspected femoral neck fracture. Data were analyzed regarding the sensitivity and specificity of bone scanning alone and with SPECT for detecting femoral neck stress fracture and grading fractures as low grade (grades I and II) or high grade (grades III and IV). RESULTS. Twelve fractures were identified in the group who underwent planar scintigraphy alone and 13 in the group who underwent planar scintigraphy with SPECT. The sensitivities of planar scintigraphy alone and with SPECT were 50% and 92.3%, respectively (p = 0.03). The accuracy of each technique for the detection of high-grade fractures was 12.5% and 70%, respectively (p = 0.025). CONCLUSION. Planar scintigraphy with SPECT had a higher sensitivity and accuracy in assessing the grade of femoral neck stress fractures than planar scintigraphy alone. The results of this study suggest that SPECT should be performed with planar bone scintigraphy for the evaluation of patients with suspected femoral neck stress fractures. C1 [Bryant, L. Ray; Song, Won S.; Banks, Kevin P.; Bui-Mansfield, Liem T.; Bradley, Yong C.] Brooke Army Med Ctr, Dept Radiol & Nucl Med, Ft Sam Houston, TX 78234 USA. [Song, Won S.; Bui-Mansfield, Liem T.; Bradley, Yong C.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Banks, KP (reprint author), Brooke Army Med Ctr, Dept Radiol & Nucl Med, Ft Sam Houston, TX 78234 USA. EM kevin.banks@amedd.army.mil NR 14 TC 11 Z9 14 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 2008 VL 191 IS 4 BP 1010 EP 1015 DI 10.2214/AJR.07.3592 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 350OX UT WOS:000259364100010 PM 18806135 ER PT J AU Brown, DJ Barry, JD AF Brown, D. J. Barry, J. D. TI Brief Physician Intervention Did Not Alter Cessation Rates in Smokers Presenting to the Emergency Department SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 24-28, 2008 CL Chicago, IL SP Amer Coll Emergency Phys C1 [Brown, D. J.; Barry, J. D.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2008 VL 52 IS 4 MA 193 BP S102 EP S102 DI 10.1016/j.annemergmed.2008.06.210 PG 1 WC Emergency Medicine SC Emergency Medicine GA 354PQ UT WOS:000259651900194 ER PT J AU Gerhardt, PT Matthews, JM Sullivan, SG AF Gerhardt, P. T. Matthews, J. M. Sullivan, S. G. TI The Effect of Systemic Antibiotic Prophylaxis and Irrigation on Penetrating Combat Wounds in a "Return-to-Duty" Population SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 24-28, 2008 CL Chicago, IL SP Amer Coll Emergency Phys C1 SAUSHEC, Brooke Army Med Ctr, Ft Sam Houston, TX USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. 1st Cavalry Div, Ft Hood, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2008 VL 52 IS 4 MA 212 BP S108 EP S108 PG 1 WC Emergency Medicine SC Emergency Medicine GA 354PQ UT WOS:000259651900212 ER PT J AU Geyer, BC Kilbourne, J Lenz, D Soreq, H Mor, TS AF Geyer, B. C. Kilbourne, J. Lenz, D. Soreq, H. Mor, T. S. TI Advanced Bioscavengers for the Emergency Treatment of Nerve Agent/Pesticide Poisoning SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 24-28, 2008 CL Chicago, IL SP Amer Coll Emergency Phys C1 Arizona State Univ, Univ Arizona Coll Med Phoenix, Tempe, AZ USA. Arizona State Univ, Biodesign Inst, Tempe, AZ USA. US Army Aberdeen Proving Grounds, Aberdeen, MD USA. Hebrew Univ Jerusalem, Jerusalem, Israel. RI mor, tsafrir/E-9422-2013 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2008 VL 52 IS 4 MA 330 BP S142 EP S142 DI 10.1016/j.annemergmed.2008.06.356 PG 1 WC Emergency Medicine SC Emergency Medicine GA 354PQ UT WOS:000259651900331 ER PT J AU Mehta, SG Spinella, P Cox, ED West, S Apocada, A Holcomb, JB AF Mehta, S. G. Spinella, P. Cox, E. D. West, S. Apocada, A. Holcomb, J. B. TI Early Identification of Combat Casualties Who Are at High Risk for Death from Severe Trauma SO ANNALS OF EMERGENCY MEDICINE LA English DT Meeting Abstract CT Research Forum of the American-College-of-Emergency-Physicians CY OCT 24-28, 2008 CL Chicago, IL SP Amer Coll Emergency Phys C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Connecticut Childrens Med Ctr, Hartford, CT USA. William Beaumont Army Med Ctr, El Paso, TX 79920 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 2008 VL 52 IS 4 MA 337 BP S144 EP S144 DI 10.1016/j.annemergmed.2008.06.363 PG 1 WC Emergency Medicine SC Emergency Medicine GA 354PQ UT WOS:000259651900338 ER PT J AU Dow, GS Chen, YF Andrews, KT Caridha, D Gerena, L Gettayacamin, M Johnson, J Li, QG Melendez, V Obaldia, N Tran, TN Kozikowski, AP AF Dow, Geoffrey S. Chen, Yufeng Andrews, Katherine T. Caridha, Diana Gerena, Lucia Gettayacamin, Montip Johnson, Jacob Li, Qigui Melendez, Victor Obaldia, Nicanor, III Tran, Thanh N. Kozikowski, Alan P. TI Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PARASITE PLASMODIUM-FALCIPARUM; ANTICANCER AGENTS; IN-VITRO; ACETYLATION; MALARIA; CELLS; CANCER; TRANSCRIPTION; GENERATION; RESISTANCE AB The antimalarial activity and pharmacology of a series of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors (HDACIs) was evaluated. In in vitro growth inhibition assays approximately 50 analogs were evaluated against four drug resistant strains of Plasmodium falciparum. The range of 50% inhibitory concentrations (IC(50)s) was 0.0005 to > 1 mu M. Five analogs exhibited IC(50)s of < 3 nM, and three of these exhibited selectivity indices of > 600. The most potent compound, WR301801 (YC-2-88) was shown to cause hyperacetylation of P. falciparum histones, which is a marker for HDAC inhibition in eukaryotic cells. The compound also inhibited malarial and mammalian HDAC activity in functional assays at low nanomolar concentrations. WR301801 did not exhibit cures in P. berghei-infected mice at oral doses as high as 640 mg/kg/day for 3 days or in P. falciparum-infected Aotus lemurinus lemurinus monkeys at oral doses of 32 mg/kg/day for 3 days, despite high relative bioavailability. The failure of monotherapy in mice may be due to a short half-life, since the compound was rapidly hydrolyzed to an inactive acid metabolite by loss of its hydroxamate group in vitro (half-life of 11 min in mouse microsomes) and in vivo (half-life in mice of 3.5 h after a single oral dose of 50 mg/kg). However, WR301801 exhibited cures in P. berghei-infected mice when combined at doses of 52 mg/kg/day orally with subcurative doses of chloroquine. Next-generation HDACIs with greater metabolic stability than WR301801 may be useful as antimalarials if combined appropriately with conventional antimalarial drugs. C1 [Dow, Geoffrey S.; Caridha, Diana; Gerena, Lucia; Johnson, Jacob; Li, Qigui; Melendez, Victor] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. [Chen, Yufeng; Kozikowski, Alan P.] Univ Illinois, Drug Discovery Program, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA. [Andrews, Katherine T.; Tran, Thanh N.] Queensland Inst Med Res, Herston, Qld 4006, Australia. [Andrews, Katherine T.; Tran, Thanh N.] Griffith Univ, Griffith Med Res Coll, Joint Program, Silver Spring, MD USA. [Andrews, Katherine T.] Univ Queensland, Australian Ctr Int & Trop Hlth, Brisbane, Qld 4072, Australia. [Gettayacamin, Montip] Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. [Obaldia, Nicanor, III] Trop Med Res Gorgas Mem Inst, Panama City, Panama. RP Dow, GS (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Geoffrey.Dow@amedd.army.mil; kozikowa@uic.edu RI Andrews, Katherine/F-9586-2011; Obaldia, Nicanor/O-8460-2015; OI Andrews, Katherine/0000-0002-1591-8979; Obaldia, Nicanor/0000-0002-3711-9449 FU Griffith University (GURG); Queensland Institute of Medical Research; ANZ Trustees Medical Research Scholarship; U.S. Military Infectious Diseases Research Program FX K.T.A. was supported by Griffith University (GURG) and the Queensland Institute of Medical Research (Directors Initiative Funding). T.N.T. was supported by an ANZ Trustees Medical Research Scholarship. The WRAIR, AFRIMS, and Gorgas Institute component of this effort was supported by the U.S. Military Infectious Diseases Research Program through the funding of core screening capabilities. NR 39 TC 47 Z9 48 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD OCT PY 2008 VL 52 IS 10 BP 3467 EP 3477 DI 10.1128/AAC.00439-08 PG 11 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 352FJ UT WOS:000259480800001 PM 18644969 ER PT J AU Abuladze, T Li, M Menetrez, MY Dean, T Senecal, A Sulakvelidze, A AF Abuladze, Tamar Li, Manrong Menetrez, Marc Y. Dean, Timothy Senecal, Andre Sulakvelidze, Alexander TI Bacteriophages reduce experimental contamination of hard surfaces, tomato, spinach, broccoli, and ground beef by Escherichia coli O157 : H7 SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID LISTERIA-MONOCYTOGENES; LYTIC BACTERIOPHAGES; PHAGE COCKTAIL; SALMONELLA; BIOCONTROL; OUTBREAK; INACTIVATION; POULTRY; CHICKEN; IRRADIATION AB A bacteriophage cocktail (designated ECP-100) containing three Myoviridae phages lytic for Escherichia coli O157:H7 was examined for its ability to reduce experimental contamination of hard surfaces (glass coverslips and gypsum boards), tomato, spinach, broccoli, and ground beef by three virulent strains of the bacterium. The hard surfaces and foods contaminated by a mixture of three E. coli O157: H7 strains were treated with ECP-100 (test samples) or sterile phosphate-buffered saline buffer (control samples), and the efficacy of phage treatment was evaluated by comparing the number of viable E. coli organisms recovered from the test and control samples. Treatments (5 min) with the ECP-100 preparation containing three different concentrations of phages (1010, 109, and 108 PFU/ml) resulted in statistically significant reductions (P = < 0.05) of 99.99%, 98%, and 94%, respectively, in the number of E. coli O157: H7 organisms recovered from the glass coverslips. Similar treatments resulted in reductions of 100%, 95%, and 85%, respectively, in the number of E. coli O157:H7 organisms recovered from the gypsum board surfaces; the reductions caused by the two most concentrated phage preparations were statistically significant. Treatment with the least concentrated preparation that elicited significantly less contamination of the hard surfaces (i.e., 10(9) PFU/ml) also significantly reduced the number of viable E. coli O157:H7 organisms on the four food samples. The observed reductions ranged from 94% (at 120 +/- 4 h posttreatment of tomato samples) to 100% (at 24 +/- 4 h posttreatment of spinach samples). The data suggest that naturally occurring bacteriophages may be useful for reducing contamination of various hard surfaces, fruits, vegetables, and ground beef by E. coli O157: H7. C1 [Abuladze, Tamar; Li, Manrong; Sulakvelidze, Alexander] Intralytix Inc, Baltimore, MD 21202 USA. [Menetrez, Marc Y.; Dean, Timothy] US EPA, Res Triangle Pk, NC 27711 USA. [Senecal, Andre] USA, Natick Soldier Res Dev & Engn Ctr, Combat Feeding Directorate, Natick, MA 01760 USA. RP Sulakvelidze, A (reprint author), Intralytix Inc, 701 E Pratt St, Baltimore, MD 21202 USA. EM asulakvelidze@intralytix.com RI Senecal, Andre/E-6605-2010 FU U.S. Environmental Protection Agency [EP-06-C-000325]; Intralytix, Inc [W911QY-07-C0125] FX The U.S. Environmental Protection Agency through its Office of Research and Development partially funded and collaborated in the research described in the manuscript (hard-surface decontamination) under contract no. EP-06-C-000325 (to A. S.). Additional funding was provided by Intralytix, Inc., and by an SBIR award, W911QY-07-C0125, from the U. S. Army (to A. S.). NR 46 TC 103 Z9 110 U1 2 U2 31 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 2008 VL 74 IS 20 BP 6230 EP 6238 DI 10.1128/AEM.01465-08 PG 9 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA 359KJ UT WOS:000259985300008 PM 18723643 ER PT J AU Sheng, CX Norwood, RA Wang, JF Thomas, J Wu, YL Zheng, ZP Tabirian, N Steeves, DM Kimball, BR Peyghambarian, N AF Sheng, ChuanXiang Norwood, Robert A. Wang, Jiafu Thomas, Jayan Wu, Yinglan Zheng, Zhiping Tabirian, N. Steeves, Diane M. Kimball, Brian R. Peyghambarian, N. TI Time-resolved studies of photoinduced birefringence in azobenzene dye-doped polymer films SO APPLIED OPTICS LA English DT Article ID VISIBLE ABSORPTION-SPECTROSCOPY; TRANS-AZOBENZENE; OPTICAL STORAGE; HOLOGRAPHY; DYNAMICS AB We measured transient photoinduced birefringence (delta n) in various azobenzene dye films by pumping with a nanosecond pulse at 532 nm and probing at 633 nm. The switch-on times for the photoinduced birefringence range from nanoseconds to milliseconds and are systematically related with the lowest optical transition energies for those films. Moreover, our results suggest that the transient photoinduced birefringence measurement is a convenient way to determine the relative energies of pi-pi* and n-pi* states in azo-based materials. (C) 2008 Optical Society of America C1 [Sheng, ChuanXiang; Norwood, Robert A.; Wang, Jiafu; Thomas, Jayan; Peyghambarian, N.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Wu, Yinglan; Zheng, Zhiping] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA. [Tabirian, N.] Beam Engn, Orlando, FL USA. [Steeves, Diane M.; Kimball, Brian R.] USA, Nanomat Sci Team, War STAR Directorate, AMSRD NSR WS BN,Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Sheng, CX (reprint author), Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. EM csheng@optics.arizona.edu RI Zheng, Zhiping/A-8123-2010 FU U. S. Army Research Office [50372-CH-MUR]; U. S. Army Natick Soldier Research FX This material is based upon work supported in part by the U. S. Army Research Office under contract/grant 50372-CH-MUR We further gratefully acknowledge financial support from the U. S. Army Natick Soldier Research, Development and Engineering Center. NR 16 TC 9 Z9 9 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD OCT 1 PY 2008 VL 47 IS 28 BP 5074 EP 5077 DI 10.1364/AO.47.005074 PG 4 WC Optics SC Optics GA 364PS UT WOS:000260348200013 PM 18830292 ER PT J AU Christesen, SD Jones, JP Lochner, JM Hyre, AM AF Christesen, Steven D. Jones, Jay Pendell Lochner, Joseph M. Hyre, Aaron M. TI Ultraviolet Raman Spectra and Cross-Sections of the G-series Nerve Agents SO APPLIED SPECTROSCOPY LA English DT Article DE Raman spectroscopy; Ultraviolet Raman spectroscopy; Cross-sections; Chemical agents; Nerve agents; Contamination detection ID UV RESONANCE RAMAN; CHEMICAL-AGENTS; HYDROLYSIS PRODUCTS; SPECTROSCOPY; CLASSIFICATION; EXCITATION; DEPENDENCE; SIMULANTS; WATER AB Ultraviolet (UV) Raman spectroscopy is being applied to the detection of chemical agent contamination of natural and man-made surfaces. In support of these efforts, we have measured the UV Raman signatures of the G-series nerve agents GA (tabun), GB (sarin), GD (soman), GF (cyclosarin), and the agent simulant diisopropyl methylphosphonate (DIMP) at 248 nm and 262 mn, as well as taking their UV Raman and UV absorption cross-sections. Of these chemicals, only GA exhibits any significant pre-resonance enhancement. We also show that reduction of the excitation wavelength from 262 nm to 248 nm effectively shifts the Raman spectrum away from a substantial sample fluorescence background, implying a significant improvement in detection capability. C1 [Christesen, Steven D.; Lochner, Joseph M.; Hyre, Aaron M.] USA, Edgewood Chem Biol Ctr, APG EA, Aberdeen Proving Ground, MD 21010 USA. [Jones, Jay Pendell] ITT Adv Engn & Sci, Abingdon, MD 21009 USA. RP Christesen, SD (reprint author), USA, Edgewood Chem Biol Ctr, APG EA, Aberdeen Proving Ground, MD 21010 USA. EM steven.christesen@us.army.mil NR 28 TC 12 Z9 12 U1 1 U2 24 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD OCT PY 2008 VL 62 IS 10 BP 1078 EP 1083 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA 359YM UT WOS:000260024200005 PM 18926015 ER PT J AU Shafer, DJ Wyllie-Echeverria, S Sherman, TD AF Shafer, Deborah J. Wyllie-Echeverria, Sandy Sherman, Timothy D. TI The potential role of climate in the distribution and zonation of the introduced seagrass Zostera japonica in North America SO AQUATIC BOTANY LA English DT Article DE Zostera japonica; temperature; growth; distribution; exotic species; climate change ID MARINA L; REPRODUCTIVE STRATEGIES; INTERTIDAL SEAGRASSES; PROPAGULE DISPERSAL; TROPICAL SEAGRASSES; WILLAPA BAY; EELGRASS; PHOTOSYNTHESIS; TEMPERATURE; COAST AB The current distribution of the introduced seagrass Zostera japonica is restricted to the mid- to upper intertidal zone in the coastal Pacific Northwest region of North America. The climate in this region is cool and wet, becoming hotter and dryer with increasing distance southward. Since temperature is likely to be an important factor affecting distribution of this species, growth of two populations located near the northern and southern limits of its established range along the Pacific Coast of North America were measured in an experimental setting across a range of temperatures typical of those in the field during the growing season (10, 20, and 30 degrees C). The effects of temperature and Population were both significant. Leaf elongation, growth, and areal productivity rates of the northern population were consistently lower than those of the southern population. Across the range of temperatures, mean leaf elongation rates ranged from 0.47 to 1.40 cm(2) shoot(-1) d(-1); mean growth rates ranged from 0.19 to 0.52 mg dry wt shoot(-1) d(-1). Mean areal productivity ranged from 0.54 to 1.92 g dry Wt m(-2) d(-1). Maximum rates of leaf elongation, growth, and areal productivity for both populations were observed at 20 degrees C. However, leaf elongation, growth, and areal productivity of the northern population declined markedly at 30 degrees C, whereas no comparable declines were observed for the southern population. This suggests that Z. japonica populations near the southern limits of its established range may be better adapted to warmer temperatures than populations near the northern range limits and further range extensions southward along the California coast may be likely. These differences could be important in predicting the outcome of competitive interactions between native and introduced seagrass species, and in determining future patterns of distribution and zonation of Pacific Coast seagrasses. (C) 2008 Elsevier B.V. All rights reserved. C1 [Shafer, Deborah J.] Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Wyllie-Echeverria, Sandy] Univ Washington, Friday Harbor Labs, Friday Harbor, WA 98250 USA. [Sherman, Timothy D.] Univ S Alabama, Dept Biol Sci, Mobile, AL 36688 USA. RP Shafer, DJ (reprint author), Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Shaferd@wes.army.mil NR 45 TC 20 Z9 22 U1 2 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3770 J9 AQUAT BOT JI Aquat. Bot. PD OCT PY 2008 VL 89 IS 3 BP 297 EP 302 DI 10.1016/j.aquabot.2008.03.005 PG 6 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 332AR UT WOS:000258054500004 ER PT J AU Segal, DR Ender, MG AF Segal, David R. Ender, Morten G. TI Sociology in military officer education - Introduction SO ARMED FORCES & SOCIETY LA English DT Editorial Material DE military academies; officer education; cross-national; military sociology AB This essay introduces a special issue of Armed Forces & Society examining sociology at military academies around the globe. Articles represent nine countries-Canada, France, Japan, the Netherlands, Russia, South Africa, Sweden, Turkey, the United States. We begin with a brief history of sociology and the military and growth of military sociology as a subfield, followed by the development of military academies in general and sociology at military academies more specifically. The essay concludes with six trends found across the nine nations and ten academies-the stigma of sociology; the cannibalization of sociology courses; co-optation of sociological concepts; charismatic leadership; radical social change; and revitalization. C1 [Ender, Morten G.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Segal, David R.] Univ Maryland, Ctr Res Mil Org, College Pk, MD 20742 USA. RP Ender, MG (reprint author), US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. EM morten.ender@usma.edu NR 66 TC 2 Z9 2 U1 0 U2 5 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2008 VL 35 IS 1 BP 3 EP 15 DI 10.1177/0095327X08321717 PG 13 WC Political Science; Sociology SC Government & Law; Sociology GA 349EY UT WOS:000259265300001 ER PT J AU Ender, MG Kelty, R Smith, I AF Ender, Morten G. Kelty, Ryan Smith, Irving TI Sociology at West Point SO ARMED FORCES & SOCIETY LA English DT Article DE West Point; teaching sociology; military officer education; cadets; military sociology; curriculum development; US Army ID MILITARY; TEXTBOOKS; SCHOOL; CORE AB Sociology and the Sociology Program at the United States Military Academy at West Point, New York, are described. Grounded in the academy's mission of educating and inspiring future leaders of character, this article focuses on the history of the Sociology Program, alignment with American Sociological Association standards, sociodemographics of cadet sociology majors, recent graduates, the curriculum, extracurricular activities, and the sociology faculty and their productivity. The Sociology Program has made significant progress in multiple areas while concomitantly being handicapped in other areas. The conclusion addresses the significance of social science in military officer education. C1 [Ender, Morten G.; Kelty, Ryan; Smith, Irving] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. RP Ender, MG (reprint author), US Mil Acad, Dept Behav Sci & Leadership, Thayer Hall 282E, West Point, NY 10996 USA. EM morten.ender@usma.edu; Ryan.Kelty@usma.edu; Irving.Smith@usma.edu NR 59 TC 0 Z9 0 U1 0 U2 2 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD OCT PY 2008 VL 35 IS 1 BP 49 EP 70 DI 10.1177/0095327X08314968 PG 22 WC Political Science; Sociology SC Government & Law; Sociology GA 349EY UT WOS:000259265300004 ER PT J AU Plackett, TP Lin-Hurtubise, KM AF Plackett, Timothy P. Lin-Hurtubise, Kevin M. TI Hepatic hemangiomas and parachuting SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE hemangioma; parachuting; injury; rupture ID CAVERNOUS HEMANGIOMAS; GIANT HEMANGIOMAS; LIVER; MANAGEMENT; DIAGNOSIS; INJURIES; RUPTURE AB Hepatic hemangiomas are relatively common benign hepatic tumors Historically, a concern for potential traumatic rupture has influenced Clinical judgment regarding optimal treatment. However, a review of the literature fails to demonstrate spontaneous or traumatic rupture as a common phenomenon. The following case report discusses an individual patient incidentally found to have large hepatic hemangiomas on CT scan during work-up for a traumatic minimally displaced pelvic fracture from parachuting. He was admitted to the general surgery service for observation. After several days of hemodynamic stability and pain control, lie was released to home With outpatient physical therapy and follow-up with the orthopedic surgery clinic. Interventional radiology was also consulted regarding his fitness to continue parachuting given his large hepatic hemangiomas. Embolization was not recommended, but rather continued observation without any restriction of physical activities. Review of the literature supports an extremely low incidence of traumatic rupture. Consequently, a hepatic hemangioma should not exclude an individual from parachuting. C1 [Plackett, Timothy P.; Lin-Hurtubise, Kevin M.] Tripler Army Med Ctr, Dept Gen Surg, Honolulu, HI 96859 USA. RP Lin-Hurtubise, KM (reprint author), Tripler Army Med Ctr, Dept Gen Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM Kevin.Lin-Hurtubise@amedd.army.mil NR 25 TC 4 Z9 5 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 2008 VL 79 IS 10 BP 986 EP 988 DI 10.3357/ASEM.2358.2008 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 355AG UT WOS:000259680400009 PM 18856190 ER PT J AU Steinweg, JM Fisk, MC McAlexander, B Groffman, PM Hardy, JP AF Steinweg, J. Megan Fisk, Melany C. McAlexander, Benjamin Groffman, Peter M. Hardy, Janet P. TI Experimental snowpack reduction alters organic matter and net N mineralization potential of soil macroaggregates in a northern hardwood forest SO BIOLOGY AND FERTILITY OF SOILS LA English DT Article DE snowpack; soil freezing; soil aggregates; nitrogen mineralization potential ID FREEZE-THAW CYCLES; FINE-ROOT DYNAMICS; AGGREGATE STABILITY; LITTER INTERFACE; CARBON; NITROGEN; STABILIZATION; FRACTIONS; TUNDRA; DISTURBANCE AB Climate change is predicted to reduce or delay annual wintertime snow pack formation in the forests of the northeastern US. Any delay in snowpack formation could increase soil freezing in winter and, thereby, alter soil characteristics and processes. We examined the hypothesis that delayed snowpack would disrupt soil structure and change organic matter bioavailability in an experimental snow removal study at the Hubbard Brook Experimental Forest (HBEF), NH, USA. Pairs of reference and snow removal treatment plots were studied in four different sites at HBEF. Snow was removed from November-January of two winters, inducing soil freezing throughout both winters. Size class distribution and organic matter concentration and content of aggregates, and carbon and nitrogen mineralization potential of size fractions were quantified for surface mineral soils in the spring of both years immediately after snowmelt. In the first year of sampling, the only significant effect of snow removal was an increase in the smallest (< 53 mu m) size fraction of mineral soil. In the second year, snow removal increased organic matter concentrations of macroaggregate (250-2,000 mu m) and microaggregate (53-250 mu m) size fractions. This change corresponded to an increase in net N mineralization potential and the ratio of N to C mineralized in the macroaggregate fraction, but there were no effects of snow removal on C mineralization. We propose that soil freezing increases the movement of organic matter from organic to mineral soil horizons and increases the N content of mineralizable substrates in mineral soil following years with delayed snowpack formation. C1 [Steinweg, J. Megan; Fisk, Melany C.; McAlexander, Benjamin] Appalachian State Univ, Dept Biol, Boone, NC 28608 USA. [Groffman, Peter M.] Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA. [Hardy, Janet P.] USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Fisk, MC (reprint author), Miami Univ, Dept Zool, Oxford, OH 45056 USA. EM fiskmc@muohio.edu FU National Science Foundation [DEB 00-75387, 98-10221] FX We thank Lisa Martel and Jim Sobieraj for assistance with field and laboratory work. This project was funded by the National Science Foundation through grant DEB 00-75387 (Ecosystem Studies) and Grant DEB 98-10221 (Long Term Ecological Research) and by support from the Heltzer Honors College at Appalachian State University. This research was conducted at the HBEF, which is owned and operated by the Northeastern Research Station, United States Department of Agriculture Forest Service. This paper is a contribution to the Hubbard Brook Ecosystem Study. NR 49 TC 11 Z9 20 U1 10 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0178-2762 J9 BIOL FERT SOILS JI Biol. Fertil. Soils PD OCT PY 2008 VL 45 IS 1 BP 1 EP 10 DI 10.1007/s00374-008-0305-3 PG 10 WC Soil Science SC Agriculture GA 354WM UT WOS:000259670600001 ER PT J AU Koppisch, AT Dhungana, S Hill, KK Boukhalfa, H Heine, HS Colip, LA Romero, RB Shou, YL Ticknor, LO Marrone, BL Hersman, LE Iyer, S Ruggiero, CE AF Koppisch, Andrew T. Dhungana, Suraj Hill, Karen K. Boukhalfa, Hakim Heine, Henry S. Colip, Leslie A. Romero, Raymond B. Shou, Yulin Ticknor, Lawrence O. Marrone, Babetta L. Hersman, Larry E. Iyer, Srinivas Ruggiero, Christy E. TI Petrobactin is produced by both pathogenic and non-pathogenic isolates of the Bacillus cereus group of bacteria SO BIOMETALS LA English DT Article DE siderophores; iron; Bacillus cereus; Bacillus anthracis; Bacillus thuringiensis ID SIDEROPHORE BIOSYNTHESIS; MYCOBACTERIUM-TUBERCULOSIS; ANTHRACIS; THURINGIENSIS; VIRULENCE; IDENTIFICATION; MACROPHAGES; TRANSPORT; SEQUENCE; PATHWAY AB Petrobactin is the primary siderophore synthesized by Bacillus anthracis str Sterne and is required for virulence of this organism in a mouse model. The siderophore's biosynthetic machinery was recently defined and gene homologues of this operon exist in several other Bacillus strains known to be mammalian pathogens, but are absent in several known to be harmless such as B. subtilis and B. lichenformis. Thus, a common hypothesis regarding siderophore production in Bacillus species is that petrobactin production is exclusive to pathogenic isolates. In order to test this hypothesis, siderophores produced by 106 strains of an in-house library of the Bacillus cereus sensu lato group were isolated and identified using a MALDI-TOF-MS assay. Strains were selected from a previously defined phylogenetic tree of this group in order to include both known pathogens and innocuous strains. Petrobactin is produced by pathogenic strains and innocuous isolates alike, and thus is not itself indicative of virulence. C1 [Koppisch, Andrew T.] No Arizona Univ, Dept Biol, Flagstaff, AZ 86004 USA. [Koppisch, Andrew T.; Dhungana, Suraj; Hill, Karen K.; Colip, Leslie A.; Romero, Raymond B.; Shou, Yulin; Marrone, Babetta L.; Hersman, Larry E.; Iyer, Srinivas] Los Alamos Natl Lab, Biosci Div, Los Alamos, NM 87545 USA. [Boukhalfa, Hakim; Ruggiero, Christy E.] Los Alamos Natl Lab, Div Chem, Los Alamos, NM 87545 USA. [Heine, Henry S.] USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. [Ticknor, Lawrence O.] Los Alamos Natl Lab, Decis Applicat Div, Los Alamos, NM 87545 USA. RP Koppisch, AT (reprint author), No Arizona Univ, Dept Biol, 500 S Beaver St, Flagstaff, AZ 86004 USA. EM koppisch@lanl.gov OI Ticknor, Lawrence/0000-0002-7967-7908 FU NSF-REU; Laboratory Directed Research; Development exploratory research; University of California [W-7405-ENG-36] FX R.B.R. is supported by the NSF-REU Bioscience and Biotechnology PUSH program for northern New Mexico. We thank Drs. David Fox and Cindy Browder for helpful discussions. This work was supported by a Laboratory Directed Research and Development exploratory research grant. Los Alamos National Laboratory is operated by the University of California for the U. S. Department of Energy under contract W-7405-ENG-36. NR 32 TC 22 Z9 23 U1 0 U2 7 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0966-0844 J9 BIOMETALS JI Biometals PD OCT PY 2008 VL 21 IS 5 BP 581 EP 589 DI 10.1007/s10534-008-9144-9 PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 344AH UT WOS:000258897100008 PM 18459058 ER PT J AU Butini, S Guarino, E Campiani, G Brindisi, M Coccone, SS Fiorini, I Novellino, E Belinskaya, T Saxena, A Gemma, S AF Butini, Stefania Guarino, Egeria Campiani, Giuseppe Brindisi, Margherita Coccone, Salvatore Sanna Fiorini, Isabella Novellino, Ettore Belinskaya, Tatyana Saxena, Ashima Gemma, Sandra TI Tacrine based human cholinesterase inhibitors: Synthesis of peptidic-tethered derivatives and their effect on potency and selectivity SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article DE cholinesterases; Alzeheimer's disease; inhibitors; tacrine ID BETA-AMYLOID AGGREGATION; ACTIVE-SITE GORGE; ALZHEIMERS-DISEASE; ACETYLCHOLINESTERASE INHIBITORS; BIOLOGICAL EVALUATION; DESIGN STRATEGY; RATIONAL DESIGN; BUTYRYLCHOLINESTERASE; BINDING; FIBRILS AB Tacrine based reversible inhibitors of cholinesterases (ChEIs) containing peptidic tethers were synthesized to interact with specific regions at the gorge level, and their potency was determined with human ( h) acetylcholinesterase and butyrylcholinesterase. Analogues 3ij and 31,m were identified as promising hits and may pave the way for the development of a new series of tacrine based enzyme selective hChEIs. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Butini, Stefania; Guarino, Egeria; Campiani, Giuseppe; Brindisi, Margherita; Coccone, Salvatore Sanna; Fiorini, Isabella; Gemma, Sandra] Univ Siena, Dipartimento Farmaco Chimico Tecnol, I-53100 Siena, Italy. [Butini, Stefania; Guarino, Egeria; Campiani, Giuseppe; Brindisi, Margherita; Coccone, Salvatore Sanna; Fiorini, Isabella; Novellino, Ettore; Gemma, Sandra] European Res Ctr Drug Discovery & Dev NatSynDrugs, I-53100 Siena, Italy. [Novellino, Ettore] Univ Naples Federico 2, Dip Chim Farmaceut & Tossicolog, I-80131 Naples, Italy. [Belinskaya, Tatyana; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Campiani, G (reprint author), Univ Siena, Dipartimento Farmaco Chimico Tecnol, Via Aldo Moro 2, I-53100 Siena, Italy. EM campiani@unisi.it RI Gemma, Sandra/D-3568-2009; butini, stefania/D-9954-2015 OI Gemma, Sandra/0000-0002-8313-2417; NR 24 TC 16 Z9 16 U1 2 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD OCT 1 PY 2008 VL 18 IS 19 BP 5213 EP 5216 DI 10.1016/j.bmcl.2008.08.076 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA 350BG UT WOS:000259326800013 PM 18786825 ER PT J AU Holmes, JP Gates, JD Benavides, LC Hueman, MT Carmichael, MG Patil, R Craig, D Mittendorf, EA Stojadinovic, A Ponniah, S Peoples, GE AF Holmes, Jarrod P. Gates, Jeremy D. Benavides, Linda C. Hueman, Matthew T. Carmichael, Mark G. Patil, Ritesh Craig, Dianna Mittendorf, Elizabeth A. Stojadinovic, Alexander Ponniah, Sathibalan Peoples, George E. TI Optimal dose and schedule of an HER-2/neu (E75) peptide vaccine to prevent breast cancer recurrence - From US Military Cancer Institute clinical trials group study I-01 and I-02 SO CANCER LA English DT Article DE breast cancer; peptide; vaccine; E75; dosing ID COLONY-STIMULATING FACTOR; CYTOTOXIC T-LYMPHOCYTES; OVARIAN-CANCER; DENDRITIC CELLS; METASTATIC BREAST; IMMUNE-RESPONSE; IN-VIVO; MELANOMA; ADJUVANT; HER2/NEU AB BACKGROUND. E75, a HER-2/neu-derived peptide, was administered as a preventive vaccine with graulocyte-macrophage-colony-stimulating factor (GM-CSF) in disease-free lymph node-positive (NP) and lymph node-negative (NN) breast cancer (BCa) patients. The optimal biologic dose (OBD) was determined based on toxicity and immunologic response. METHODS. Patients were vaccinated over 6 months (3, 4, or 6 times) with different doses of E75 plus GM-CSF. Toxicities were graded per National Cancer Institute Common Terminology Criteria. GM-CSF vas reduced for significant toxicity Immunologic response was measured by delayed type hypersensitivity test (DTH), and E75-specific CD8(+) T-cells were quantified with human leukocyte antigen-A2:immunoglobulin G diner and flow cytometry. RESULTS. Ninety-nine patients (48 NP and 51 NN) were vaccinated in 7 dose groups. The OBD was 1000 mu g E75 plus 250 mu g GM-CSF monthly x 6. The optimal dose group (ODG, n = 29) experienced similar toxicities to the suboptimal dose group (SDG, n = 70), which was comprised of the remaining 6 groups. The ODG demonstrated a trend toward an increase in the average postvaccine dimer (0.87 +/- 0.10% vs 0.67 +/- 0.05%; P =.07), a significantly larger DTH response (21.5 +/- 2.5 mm vs 11.3 +/- 1.3 mm; P =.0002), and a trend toward decreased recurrences (3.4% vs 12.9%; P =.27). Compared with the SDG, the ODG had larger tumors (percentage >= T2: 55% vs 23%; P =.004), more positive nodes (percentage NP: 76% vs 37%; P =.001), and higher grade tumors (percentage grade 3: 52% vs 30%; P =.07), but a shorter median follow-up time (20 months vs 32 months; P <.001). CONCLUSIONS. Compared with suboptimally dosed patients, the optimally dosed E75 vaccine in disease-free BCa patients had similar toxicity but enhanced HER-2/neu-specific immunity that may lead to decreased recurrences with additional follow-up. C1 [Gates, Jeremy D.; Benavides, Linda C.; Peoples, George E.] Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, Ft Sam Houston, TX 78234 USA. [Holmes, Jarrod P.] USN, San Diego Med Ctr, Div Hematol & Med Oncol, Dept Med, San Diego, CA 92152 USA. [Hueman, Matthew T.; Carmichael, Mark G.; Stojadinovic, Alexander; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA. [Carmichael, Mark G.] Walter Reed Army Med Ctr, Dept Med, Hematol & Med Oncol Serv, Washington, DC 20307 USA. [Patil, Ritesh; Craig, Dianna] Windber Med Ctr, Joyce Murtha Breast Care Ctr, Windber, PA USA. [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Gen Surg Serv, Dept Surg, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil FU United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences; Department of Clinical Investigation at Walter Reed Army Medical Center. FX Supported by the United States Military Cancer Institute, Department of Surgery, Uniformed Services University of the Health Sciences, and the Department of Clinical Investigation at Walter Reed Army Medical Center. NR 34 TC 33 Z9 35 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD OCT 1 PY 2008 VL 113 IS 7 BP 1666 EP 1675 DI 10.1002/cncr.23772 PG 10 WC Oncology SC Oncology GA 354TK UT WOS:000259661700024 PM 18726994 ER PT J AU Rodon, J Garrison, M Hammond, LA de Bono, J Smith, L Forero, L Hao, D Takimoto, C Lambert, JM Pandite, L Howard, M Xie, HS Tolcher, AW AF Rodon, Jordi Garrison, Mitchell Hammond, Lisa A. de Bono, Johann Smith, Lon Forero, Leonardo Hao, Desiree Takimoto, Chris Lambert, John M. Pandite, Lini Howard, Maria Xie, Hongsheng Tolcher, Anthony W. TI Cantuzumab mertansine in a three-times a week schedule: a phase I and pharmacokinetic study SO CANCER CHEMOTHERAPY AND PHARMACOLOGY LA English DT Article DE cantuzumab mertansine; SB-408075; huC242-DM1; CanAg; immunoconjugates; pharmacokinetics; phase I ID MAYTANSINE; CANCER; EXPRESSION; INFUSION; ANTIGEN; CA-19-9; TUMORS; CA-50 AB Purpose Cantuzumab mertansine (SB-408075; huC242-DM1) is a conjugate of the maytansinoid drug DM1 to the antibody huC242, which targets CanAg antigen. In previous studies, cantuzumab mertansine was considered safe and tolerable, but transaminitis precluded tolerance of higher doses. Based on those studies, it was suggested that treatment at intervals of the half-life of the intact immunoconjugate may allow a higher dose density. This provided the rationale for the three-times weekly treatment explored in this protocol. Methods Patients with advanced solid tumors and documented CanAg expression were treated with escalating doses of cantuzumab mertansine IV administered three-times a week in a 3 out of 4 weeks schedule. Plasma samples were assayed to determine pharmacokinetic parameters. Results Twenty patients (pts) with colon (11/20), rectal carcinomas (2/20), or other malignancies (7/20) were treated with doses ranging from 30 to 60 mg/m(2) per day of cantuzumab mertansine IV three-times a week. The maximum tolerated dose (MTD) was 45 mg/m(2), and the dose-limiting toxicity was grade 3 transaminitis. Hepatic, hematologic, and neurosensory effects occurred, but were rarely severe with repetitive treatment at doses of 45 mg/m(2). Conclusions Treatment with cantuzumab mertansine at 45 mg/m(2) per day three-times weekly x 3-every-4-week schedule proved that a dose-intense treatment with an immunoconjugate can be safely administered. The pharmacokinetic profile of the intact immunoconjugate indicates that the linker is cleaved with a half-life of about 2 days, resulting in faster clearance of the maytansinoid relative to the antibody. Therefore, with the development of second-generation immunoconjugates, there is a need for improvement of the immunoconjugate linker to take full advantage of the slow clearance of full-length antibody molecules. C1 [Rodon, Jordi; Hammond, Lisa A.; de Bono, Johann; Smith, Lon; Forero, Leonardo; Hao, Desiree; Takimoto, Chris; Tolcher, Anthony W.] Canc Therapy & Res Ctr S Texas, Inst Drug Dev, San Antonio, TX 78229 USA. [Garrison, Mitchell] Brooke Army Med Ctr, San Antonio, TX USA. [Lambert, John M.; Howard, Maria; Xie, Hongsheng] ImmunoGen, Cambridge, MA USA. [Pandite, Lini] Glaxo SmithKline, Collegeville, PA USA. RP Rodon, J (reprint author), Canc Therapy & Res Ctr S Texas, Inst Drug Dev, 7979 Wurzbach,Suite 414, San Antonio, TX 78229 USA. EM jrodon@idd.org NR 18 TC 19 Z9 19 U1 1 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0344-5704 J9 CANCER CHEMOTH PHARM JI Cancer Chemother. Pharmacol. PD OCT PY 2008 VL 62 IS 5 BP 911 EP 919 DI 10.1007/s00280-007-0672-8 PG 9 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA 338SB UT WOS:000258527900020 PM 18301896 ER PT J AU Mittendorf, EA Holmes, JP Ponniah, S Peoples, GE AF Mittendorf, Elizabeth A. Holmes, Jarrod P. Ponniah, Sathibalan Peoples, George E. TI The E75 HER2/neu peptide vaccine SO CANCER IMMUNOLOGY IMMUNOTHERAPY LA English DT Article; Proceedings Paper CT Conference of the European-Society-for-Medical-Oncology/European-Society-for-Cancer-Immuno logy-and-Immunotherapy/International Symposium on Immunology CY NOV 15-17, 2007 CL Athens, GREECE SP European Soc Med Oncol, European Soc Canc Immunol & Immunotherapy DE breast cancer; E75; peptide; vaccine; clinical trials ID BREAST-CANCER PATIENTS; CYTOTOXIC T-LYMPHOCYTES; GM-CSF VACCINE; OVARIAN-CANCER; NEU ONCOGENE; DENDRITIC CELLS; IN-VIVO; HER-2/NEU; IMMUNITY; ANTIGENS AB E75 (HER2/neu 369-377) is an immunogenic peptide from the HER2/neu protein which is overexpressed in many breast cancer patients. A large amount of preclinical work and a small number of Phase I trials have been completed evaluating the vaccine potential of the E75 peptide mixed with an immunoadjuvant. Our group has performed two concurrent E75 + GM-CSF Phase II trials in node-positive and node-negative disease-free breast cancer patients. These trials, totaling 186 patients, were designed to assess the ability of the E75 vaccine to prevent disease recurrence in these high risk patients. In this review article, we discuss the safety of the vaccine, the immunologic response to the peptide, and most importantly, the potential clinical benefit of the vaccine. The recurrence rate, mortality associated with recurrence, and the distribution of recurrences are presented and discussed. Additionally, the lessons learned from these trials to include optimal dosing and the need for booster inoculations are addressed. We also present data exploring possible explanations and mechanisms behind the potential clinical utility of this simple single epitope vaccine. Finally, we present some of the future directions for our Cancer Vaccine Development Program assessing multi-epitope peptide vaccines and combination immunotherapies. C1 [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA. [Holmes, Jarrod P.] Naval Med Ctr San Diego, Div Hematol & Med Oncol, Dept Med, San Diego, CA USA. [Holmes, Jarrod P.; Ponniah, Sathibalan; Peoples, George E.] Uniformed Serv Univ Hlth Sci, Dept Surg, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA. [Peoples, George E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil NR 52 TC 55 Z9 59 U1 0 U2 12 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0340-7004 J9 CANCER IMMUNOL IMMUN JI Cancer Immunol. Immunother. PD OCT PY 2008 VL 57 IS 10 BP 1511 EP 1521 DI 10.1007/s00262-008-0540-3 PG 11 WC Oncology; Immunology SC Oncology; Immunology GA 330BI UT WOS:000257913900008 PM 18536917 ER PT J AU McClung, JP AF McClung, James P. TI Iron homeostasis and environmental extremes: Focus on physical activity SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article; Proceedings Paper CT European-Tissue-Culture-Society Workshop CY APR 19, 2007 CL Univ Coll London, London, ENGLAND SP European Tissue Culture Soc HO Univ Coll London ID DEFICIENCY ANEMIA; PEPTIDE HEPCIDIN; US-ARMY; EXERCISE; METABOLISM; RUNNERS; GENE C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 07160 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Kansas St,Bldg 42, Natick, MA 07160 USA. EM james.mcclung@na.amedd.army.mil RI McClung, James/A-1989-2009 NR 22 TC 0 Z9 0 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD OCT PY 2008 VL 24 IS 5 BP 459 EP 462 PG 4 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA 340OF UT WOS:000258654200016 ER PT J AU Waag, DM England, MJ Bolt, CR Williams, JC AF Waag, David M. England, Marilyn J. Bolt, Christopher R. Williams, Jim C. TI Low-dose priming before vaccination with the phase I chloroform-methanol residue vaccine against Q fever enhances humoral and cellular immune responses to Coxiella burnetii SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; HUMAN VOLUNTEERS; Q-VAX; LIPOPOLYSACCHARIDES; IMMUNOGENICITY; ANTIGENS; EFFICACY; STRAIN; MICE AB Although the phase I Coxiella burnetii cellular vaccine is completely efficacious in humans, adverse local and systemic reactions may develop if immune individuals are inadvertently vaccinated. The phase I chloroform-methanol residue (CMRI) vaccine was developed as a potentially safer alternative. Human volunteers with no evidence of previous exposure to C. burnetii received a subcutaneous vaccination with the CMRI vaccine in phase I studies under protocol IND 3516 to evaluate the safety and immunogenicity of the vaccine. This clinical trial tested escalating doses of the CMRI vaccine, ranging from 0.3 to 60 mu g, followed by a booster dose of 30 mu g, in a placebo-controlled study. Although priming doses of the CMRI vaccine did not induce a specific antibody detectable by enzyme-linked immunosorbent assay, booster vaccination stimulated the production of significant levels of anti-C. burnetii antibody. Peripheral blood cells (PBCs) of vaccinees responded to C. burnetii cellular antigen in vitro in a vaccine dose-dependent manner. After the booster dose, PBCs were activated by recall antigen in vitro, regardless of the priming dose. These findings suggest that vaccination with the CMRI vaccine can effectively prime the immune system to mount significant anamnestic responses after infection. C1 [Waag, David M.; England, Marilyn J.; Bolt, Christopher R.; Williams, Jim C.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Waag, DM (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM david.waag@amedd.army.mil FU Defense Threat Reduction Agency [5.10023_05_RD_B] FX We thank David Bunner and the staff of Medical Division, USAMRIID, for recruiting human volunteers needed for this study and providing clinical monitoring after vaccination and boosting. Gene Nelson of the Biometrics and Information Management Division, USAMRIID, provided the statistical analysis.; Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U. S. Army.; This effort was funded by Defense Threat Reduction Agency project number 5.10023_05_RD_B.; In the conduct of research where humans were the subjects, the investigators adhered to the policies regarding the protection of human subjects prescribed by 45 CFR 46 and 32 CFR 219 (Protection of Human Subjects). NR 43 TC 11 Z9 12 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD OCT PY 2008 VL 15 IS 10 BP 1505 EP 1512 DI 10.1128/CVI.00119-08 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 357BQ UT WOS:000259821700002 PM 18701647 ER PT J AU Ergut, A Therrien, RJ Levendis, YA Richter, H Howard, JB Carlson, JB AF Ergut, Ali Therrien, Rick J. Levendis, Yiannis A. Richter, Henning Howard, Jack B. Carlson, Joel B. TI The effect of temperature on the soot onset chemistry in one-dimensional, atmospheric-pressure, premixed ethylbenzene flames SO COMBUSTION AND FLAME LA English DT Article DE Premixed flames; Ethylbenzene; Soot onset; Flame temperature; PAH ID POLYCYCLIC AROMATIC-HYDROCARBONS; PAH; COMBUSTION; OXIDATION; GROWTH AB This work was conducted to investigate the effects of temperature on soot formation/oxidation chemistry in the vicinity of the soot onset threshold (phi critical) in one-dimensional, laminar, atmospheric-pressure premixed ethylbenzene flames. The effects of temperature on the evolution of soot precursors were observed just prior and subsequent to soot onset. Liquid ethylbenzene was prevaporized in nitrogen and blended with an oxygen-nitrogen mixture and, upon ignition, premixed flat flames were stabilized over a burner at atmospheric pressure. Three flames at the same fuel-to-air equivalence ratio (phi = 1.74) but with different temperature profiles were obtained by regulating the total heat loss from the flame to the burner, as a result of altering the cold gas velocity of the reacting bases through the burner. A 100-K spread was detected among the three flame temperature profiles. The coolest flame was slightly sooting, the intermediate temperature flame was at the visible onset of sooting, and the hottest flame was not sooting. Combustion products were sampled at various heights in these flames. CO and CO2 mole fractions were found to increase with temperature, supporting the hypothesis that with increasing temperature the rate of oxidation reactions increases faster than the rate of soot formation reactions. Again supporting the same hypothesis, the mole fractions of at least some of the suspected soot precursor hydrocarbons decreased with increasing temperature. Similarly, both the number and the concentrations of detected polycyclic aromatic hydrocarbons (PAH) and oxygenated aromatic hydrocarbons were highest in the slightly sooting, i.e., the coolest flame. This flame also had the highest condensed phase/gaseous phase PAH ratio among the three flames. However, whereas in all three flames the mole fractions of PAH were disparate in the broad neighborhood of the flame zone, they converged to similar values in the postflame zone at 7 mm height from the surface of the burner. Experimentally obtained mole fractions of effluent species were compared with predictions from a detailed kinetic model. (c) 2008 The Combustion Institute. Published by Elsevier Inc. All rights reserved. C1 [Ergut, Ali; Therrien, Rick J.; Levendis, Yiannis A.] Northeastern Univ, Boston, MA 02115 USA. [Richter, Henning; Howard, Jack B.] MIT, Cambridge, MA 02139 USA. [Carlson, Joel B.] USA, SBCCOM, Natick Soldier Ctr, Natick, MA 01760 USA. RP Levendis, YA (reprint author), Northeastern Univ, Boston, MA 02115 USA. EM y.levendis@neu.edu NR 30 TC 13 Z9 14 U1 1 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD OCT PY 2008 VL 155 IS 1-2 BP 232 EP 246 DI 10.1016/j.combustflame.2008.03.009 PG 15 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA 364VB UT WOS:000260362400016 ER PT J AU Wilk, J West, J Marcus, S Countis, L Regier, D Olfson, M AF Wilk, Joshua E. West, Joyce C. Marcus, Steven C. Countis, Lisa Regier, Darrel A. Olfson, Mark TI Family Contact and the Management of Medication Non-adherence in Schizophrenia SO COMMUNITY MENTAL HEALTH JOURNAL LA English DT Article; Proceedings Paper CT 159th Annual Meeting of the American-Psychiatric-Association CY MAY 20-25, 2006 CL Toronto, CANADA SP Amer Psychiat Assoc DE Schizophrenia; Non-adherence; Family contact; Medication management; Antipsychotic ID NONCOMPLIANCE AB We compare psychiatric management of antipsychotic non-adherence among schizophrenia outpatients with high and low levels of family contact. A national survey was conducted among a random sample of psychiatrists treating schizophrenia, providing data on 310 patients. Patients were stratified by level of family contact. Psychiatrists were more likely to use family interventions to manage non-adherence among patients with high family contact. Psychiatrists were significantly more likely to change antipsychotic dosing in patients with high family contact, though less likely to start depot antipsychotic medications. Family interventions appear to be commonly used in the psychiatric management of medication non-adherence in schizophrenia. C1 [Wilk, Joshua E.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Wilk, Joshua E.; West, Joyce C.; Marcus, Steven C.; Countis, Lisa; Regier, Darrel A.] APIRE, Amer Psychiat Practice Res Network PRN, Arlington, VA 22209 USA. [Olfson, Mark] Columbia Univ, Coll Phys & Surg, New York State Psychiat Inst, Dept Psychiat, Columbia, NY USA. RP Wilk, J (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Dr, Silver Spring, MD 20910 USA. EM joshuawilk@hotmail.com RI Wilk, Joshua/B-3616-2011 FU NIMH NIH HHS [MH-61530] NR 10 TC 3 Z9 3 U1 0 U2 2 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0010-3853 J9 COMMUNITY MENT HLT J JI Community Ment. Health J. PD OCT PY 2008 VL 44 IS 5 BP 377 EP 380 DI 10.1007/s10597-008-9139-6 PG 4 WC Health Policy & Services; Public, Environmental & Occupational Health; Psychiatry SC Health Care Sciences & Services; Public, Environmental & Occupational Health; Psychiatry GA 382ES UT WOS:000261588600008 PM 18465228 ER PT J AU Hebert, CG Valdes, JJ Bentley, WE AF Hebert, Colin G. Valdes, James J. Bentley, William E. TI Beyond silencing - engineering applications of RNA interference and antisense technology for altering cellular phenotype SO CURRENT OPINION IN BIOTECHNOLOGY LA English DT Review ID ENTERICA SEROVAR TYPHIMURIUM; EXTERNAL GUIDE SEQUENCES; DOUBLE-STRANDED-RNA; ESCHERICHIA-COLI; GENE-EXPRESSION; AMIKACIN RESISTANCE; DOWN-REGULATION; MESSENGER-RNA; IN-VITRO; CELLS AB Since its discovery 10 years ago, RNA interference (RNAi) has evolved from a research tool into a powerful method for altering the phenotype of cells and whole organisms. Its near universal applicability coupled with its pinpoint accuracy for suppressing target proteins has altered the landscape of many fields. While there is considerable intellectual investment in therapeutics, its potential extends far beyond. In this review, we explore some of these emerging applications - metabolic engineering for enhancing recombinant protein production in both insect and mammalian cell systems, antisense technologies in bacteria as next generation antibiotics, and RNAi in plant biotechnology for improving productivity and nutritional value. C1 [Hebert, Colin G.; Bentley, William E.] Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA. [Hebert, Colin G.; Valdes, James J.] USA, Edgewood Chem Biol Ctr, AMSRD ECB AP B Michel E3330, Aberdeen Proving Ground, MD 21010 USA. [Bentley, William E.] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20742 USA. [Hebert, Colin G.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA. RP Bentley, WE (reprint author), Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, 5115 Plant Sci Bldg, College Pk, MD 20742 USA. EM bentley@eng.umd.edu FU Department of Defense (CREST Fellowship to CGH); National Institutes of Health [GM170851-01] FX Partial support of this work was provided by the Department of Defense (CREST Fellowship to CGH) and the National Institutes of Health (GM170851-01). NR 59 TC 31 Z9 33 U1 1 U2 18 PU CURRENT BIOLOGY LTD PI LONDON PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND SN 0958-1669 J9 CURR OPIN BIOTECH JI Curr. Opin. Biotechnol. PD OCT PY 2008 VL 19 IS 5 BP 500 EP 505 DI 10.1016/j.copbio.2008.08.006 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 365EE UT WOS:000260387900013 PM 18760358 ER PT J AU Malla, S Thakur, GD Shrestha, SK Banjeree, MK Thapa, LB Gongal, G Ghimire, P Upadhyay, BP Gautam, P Khanal, S Nisaluk, A Jarman, RG Gibbons, RV AF Malla, Sarala Thakur, Garib D. Shrestha, Sanjaya K. Banjeree, Manas K. Thapa, Laxmi B. Gongal, Gyanendra Ghimire, Prakash Upadhyay, Bishnu P. Gautam, Purosotam Khanal, Shyam Nisaluk, Ananda Jarman, Richard G. Gibbons, Robert V. TI Identification of all dengue serotypes in Nepal SO EMERGING INFECTIOUS DISEASES LA English DT Letter ID VIRUS; INFECTIONS C1 [Malla, Sarala; Upadhyay, Bishnu P.; Khanal, Shyam] Natl Publ Hlth Lab, Kathmandu, Nepal. [Thakur, Garib D.; Banjeree, Manas K.; Thapa, Laxmi B.; Gautam, Purosotam] Epidemiol & Dis Control Div, Kathmandu, Nepal. [Shrestha, Sanjaya K.] Walter Reed Armed Forces Res Inst Med Sci, Kathmandu, Nepal. [Gongal, Gyanendra] WHO Reg Off SE Asia, New Delhi, India. [Ghimire, Prakash] Tribhuvan Univ, Tribhuvan, Nepal. [Nisaluk, Ananda; Jarman, Richard G.; Gibbons, Robert V.] USA, Med Command, Armed Forces Res Inst Med Sci, Bangkok, Thailand. RP Gibbons, RV (reprint author), USA, Med Command, Armed Forces Res Inst Med Sci, APO, AP 96546 USA. EM robert.gibbons@afrims.org NR 10 TC 18 Z9 18 U1 0 U2 2 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD OCT PY 2008 VL 14 IS 10 BP 1669 EP 1670 DI 10.3201/eid1410.080432 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 357JK UT WOS:000259841900034 PM 18826846 ER PT J AU Fuller, RW Ehrgott, JQ Heard, WF Robert, SD Stinson, RD Solanki, K Horstemeyer, MF AF Fuller, R. W. Ehrgott, J. Q., Jr. Heard, W. F. Robert, S. D. Stinson, R. D. Solanki, K. Horstemeyer, M. F. TI Failure analysis of AISI 304 stainless steel shaft SO ENGINEERING FAILURE ANALYSIS LA English DT Article DE mixer shaft; AISI 304 steel; intergranular stress cracking; heat affected zones; fracture surface AB In this paper, we present a failure analysis methodology of a structural component using a conventional 14-step failure analysis approach. This failure analysis methodology focused on observation, information gathering, preliminary visual examination and record keeping, nondestructive testing, mechanical testing, selecting/preservation of fracture surfaces, macroscopic examinations, microscopic examinations, metallography, failure mechanism determination, chemical analysis, mechanical failure analysis, testing under simulated service conditions, and final analysis and report. The application of this methodology is demonstrated in the failure analysis of a mixer unit shaft made of AISI 304 stainless steel. Using this failure analysis approach, we pinpointed the primary mode of failure and developed a means of circumventing this type of failure in the future. The results show that the steel shaft failed due to intergranular stress cracking (sensitization during welding) at the heat affected zones (weld plugs). (C) 2007 Elsevier Ltd. All rights reserved. C1 [Ehrgott, J. Q., Jr.; Heard, W. F.; Robert, S. D.; Stinson, R. D.] USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. [Solanki, K.; Horstemeyer, M. F.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA. [Fuller, R. W.] Entergy Operat, Grand Gulf Nucl Stn, Design Engn Mech Syst, Port Gibson, MS 39150 USA. RP Fuller, RW (reprint author), Entergy Operat, Grand Gulf Nucl Stn, Design Engn Mech Syst, Bald Hill Rd, Port Gibson, MS 39150 USA. EM rfullel@entergy.com; jay.q.ehrgott@erdc.usace.army.mil; william.f.heard@erdc.usace.army.mil; stephen.d.robert@erdc.usace.army.mil; ryan.d.stinson@erdc.usace.army.mil; kns3@cavs.msstate.edu RI Solanki, Kiran/E-8337-2010; OI Solanki, Kiran/0000-0002-4385-620X; Horstemeyer, Mark/0000-0003-4230-0063 NR 5 TC 14 Z9 14 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1350-6307 J9 ENG FAIL ANAL JI Eng. Fail. Anal. PD OCT PY 2008 VL 15 IS 7 BP 835 EP 846 DI 10.1016/j.engfailanal.2007.11.001 PG 12 WC Engineering, Mechanical; Materials Science, Characterization & Testing SC Engineering; Materials Science GA 311WR UT WOS:000256631600004 ER PT J AU Senchak, AJ Bager, J Cable, B AF Senchak, Andrew J. Bager, Jennifer Cable, Benjamin TI Oropharyngeal and laryngeal burn resulting from exposure to endoscope disinfectant: A case report SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article AB Iatrogenic injury from medical disinfectants is an uncommon but potentially devastating complication. We report an unusual, but severe, upper aerodigestive complication from the use of ortho-Phthalaldehyde solution, a commonly used endoscope disinfectant. C1 [Senchak, Andrew J.; Bager, Jennifer; Cable, Benjamin] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI USA. RP Senchak, AJ (reprint author), Bayne Jones Army Community Hosp, ENT Clin, Ft Polk, LA 71459 USA. EM andrew.senchak@amedd.army.mil NR 8 TC 1 Z9 1 U1 0 U2 1 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD OCT PY 2008 VL 87 IS 10 BP 580 EP 581 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA V10PD UT WOS:000207475000011 PM 18833537 ER PT J AU Jangpatarapongsa, K Chootong, P Sattabongkot, J Chotivanich, K Sirichaisinthop, J Tungpradabkul, S Hisaeda, H Troye-Blomberg, M Cui, L Udomsangpetch, R AF Jangpatarapongsa, Kulachart Chootong, Patchanee Sattabongkot, Jetsumon Chotivanich, Kesinee Sirichaisinthop, Jeeraphat Tungpradabkul, Sumalee Hisaeda, Hajime Troye-Blomberg, Marita Cui, Liwang Udomsangpetch, Rachanee TI Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE Dendritic cell; IL-10; Malaria; Plasmodium vivax; Regulatory T cell ID CIRCUMSPOROZOITE PROTEIN; MALARIA; FALCIPARUM; DIFFERENTIATION; FOXP3; EXPRESSION; INFECTION; RESPONSES; SUBSETS; GENERATION AB Immunity induced by Plasmodium vivax infections leads to memory T-cell recruitment and activation during subsequent infections. Here, we investigated the role of regulatory T cells (Treg) in coordination with the host immune response during P. vivax infection. our results showed a significant increase in the percentage of FOXP3(+) Treg, IL-10-secreting Type I Treg (Tr1) and IL-10 levels in patients with acute P. vivax infection as compared with those found in either naive or immune controls. The concurrent increase in the Treg population could also be reproduced in vitro using peripheral blood mononuclear cells from naive controls stimulated with crude antigens extracted from P. vivax-infected red blood cells. Acute P. vivax infections were associated with a significant decrease in the numbers of DC, indicating a general immunosuppression during P. vivax infections. However, unlike P. falciparum infections, we found that the ratio of myeloid DC (MDC) to plasmacytoid. DC (PDC) was significantly lower in acute R vivax patients than that of naive and immune controls. Moreover, the reduction in PDC may be partly responsible for the poor antibody responses during P. vivax infections. Taken together, these results suggest that P. vivax parasites interact with DC, which alters the MDC/PDC ratio that potentially leads to Treg activation and IL-10 release. C1 [Jangpatarapongsa, Kulachart; Chootong, Patchanee; Udomsangpetch, Rachanee] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand. [Jangpatarapongsa, Kulachart; Chootong, Patchanee; Udomsangpetch, Rachanee] Mahidol Univ, Fac Med Technol, Dept Clin Microbiol, Bangkok 10700, Thailand. [Sattabongkot, Jetsumon] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. [Chotivanich, Kesinee] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok, Thailand. [Sirichaisinthop, Jeeraphat] Minist Publ Hlth, Ctr Malaria Res & Training, Sara Buri, Thailand. [Tungpradabkul, Sumalee] Mahidol Univ, Fac Sci, Dept Biochem, Bangkok 10400, Thailand. [Hisaeda, Hajime] Kyushu Univ, Fac Med Sci, Dept Parasitol, Fukuoka 812, Japan. [Troye-Blomberg, Marita] Stockholm Univ, Wenner Gren Inst, Dept Immunol, S-10691 Stockholm, Sweden. [Cui, Liwang] Penn State Univ, Dept Entomol, University Pk, PA 16802 USA. RP Udomsangpetch, R (reprint author), Mahidol Univ, Fac Sci, Dept Pathobiol, Rama 6 Rd, Bangkok 10400, Thailand. EM oadworld@yahoo.com; scrudmu@yahoo.com RI Troye-Blomberg, Marita/B-9210-2016 OI Troye-Blomberg, Marita/0000-0002-2804-0325 FU Fogarty International Center (FIC); National Institutes of Health (NIH); The Thailand Research Fund; The Commission on Higher Education [CHE-RES-PD]; BioMalPar; FIC, NIH [D43-TW006571] FX We thank all the staff at the Mae Sot and Mae Kasa Malaria Clinics, the Department of Entomology, AFRIMS, Bangkok, and the Malaria Training Center, Saraburi, Thailand, for collection of the samples. We also thank M. Hagstedt, and W. Jangiam for technical support. KJ was a research fellow supported by the Fogarty International Center (FIC), National Institutes of Health (NIH). This work was partly supported by The Thailand Research Fund to RU, by The Commission on Higher Education to KJ (CHE-RES-PD), by BioMalPar to MT and by a grant (D43-TW006571) to LC from FIC, NIH. NR 43 TC 51 Z9 57 U1 1 U2 4 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD OCT PY 2008 VL 38 IS 10 BP 2697 EP 2705 DI 10.1002/eji.200838186 PG 9 WC Immunology SC Immunology GA 369KN UT WOS:000260693500007 PM 18825754 ER PT J AU Paranavitana, C Pittman, PR Velauthapillai, M Zelazowska, E DaSilva, L AF Paranavitana, Chrysanthi Pittman, Phillip R. Velauthapillai, Mahendran Zelazowska, Elzbieta DaSilva, Luis TI Transcriptional profiling of Francisella tularensis infected peripheral blood mononuclear cells: a predictive tool for tularemia SO FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY LA English DT Article DE tularemia; microarray; gene expression; PBMCs ID CHAIN FATTY-ACIDS; GENE-EXPRESSION; INTRACELLULAR BACTERIUM; IMMUNE-RESPONSES; INNATE; MACROPHAGES; ACTIVATION; PROLIFERATION; RECOGNITION; PROGRAMS AB In this study, we analyzed temporal gene expression patterns in human peripheral blood mononuclear cells (PBMCs) infected with the Francisella tularensis live vaccine strain from 1 to 24 h utilizing a whole human Affymetrix (R) gene chip. We found that a considerable number of induced genes had similar expression patterns and functions as reported previously for gene expression profiling in patients with ulceroglandular tularemia. Among the six uniquely regulated genes reported for tularemia patients as being part of the alarm signal gene cluster, five, namely caspase 1, PSME2, TAP-1, GBP1, and GCH1, were induced in vitro. We also detected four out of the seven potential biomarkers reported in tularemia patients, namely TNFAIP6 at 4 h and STAT1, TNFSF10, and SECTM1 at 16 and 24 h. These observations underscore the value of using microarray expression profiling as an in vitro tool to identify potential biomarkers for human infection and disease. Our results indicate the potential involvement of several host pathways/processes in Francisella infection, notably those involved in calcium, zinc ion binding, PPAR signaling, and lipid metabolism, which further refines the current knowledge of F. tularensis infection and its effects on the human host. Ultimately, this study provides support for utilizing in vitro microarray gene expression profiling in human PBMCs to identify biomarkers of infection and predict in vivo immune responses to infectious agents. C1 [Paranavitana, Chrysanthi; Zelazowska, Elzbieta] Walter Reed Army Inst Res, Dept Bacterial & Rickettsial Dis, Silver Spring, MD 20190 USA. [Pittman, Phillip R.] USA, Med Res Inst Infect Dis, Div Med, Frederick, MD USA. [Velauthapillai, Mahendran] Georgetown Univ, Dept Comp Sci, Washington, DC USA. [DaSilva, Luis] USAMRIID, Ctr Aerobiol Sci, Frederick, MD USA. RP Paranavitana, C (reprint author), Walter Reed Army Inst Res, Dept Bacterial & Rickettsial Dis, Bldg 503,Room 2N59, Silver Spring, MD 20190 USA. EM chrysanthi.paranavitana@amedd.army.mil FU Defense Threat Reduction Agency (DTRA); Department of Defense FX The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army, Department of the Air Force, or the Department of Defense. This work was supported by a grant to C.P. from the Defense Threat Reduction Agency (DTRA) of the Department of Defense. NR 31 TC 16 Z9 16 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0928-8244 J9 FEMS IMMUNOL MED MIC JI FEMS Immunol. Med. Microbiol. PD OCT PY 2008 VL 54 IS 1 BP 92 EP 103 DI 10.1111/j.1574-695X.2008.00456.x PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 345VI UT WOS:000259025100010 PM 18680519 ER PT J AU Wu, Y Shi, XR Guo, SW AF Wu, Yan Shi, Xuerong Guo, Sun-Wei TI The knockdown of progesterone receptor isoform B (PR-B) promotes proliferation in immortalized endometrial stromal cells SO FERTILITY AND STERILITY LA English DT Editorial Material ID FACTOR-KAPPA-B; EXPRESSION; APOPTOSIS; MEDIATE; WOMEN AB The knockdown of PR-B by siRNA resulted in a significant increase in proliferation in an immortalized endometrial stromal cell line. This suggests that PR-B knockdown might be responsible, at least in part, for increased proliferation and resistance to apoptosis as seen in the eutopic and ectopic endometrium of women with endometriosis. C1 [Guo, Sun-Wei] Shanghai Jiao Tong Univ, Sch Med, Inst Obstet & Gynaecol Res, Renji Hosp, Shanghai 200001, Peoples R China. [Wu, Yan] Ctr Hematol & Oncol Mol Therapeut, Taussig Canc Ctr, Cleveland, OH USA. [Shi, Xuerong] Walter Reed Army Inst Res, Div Biochem, Dept Biochem Pharmacol, Silver Spring, MD USA. RP Guo, SW (reprint author), Shanghai Jiao Tong Univ, Sch Med, Inst Obstet & Gynaecol Res, Renji Hosp, Shanghai 200001, Peoples R China. EM hoxa10@gmail.com NR 20 TC 21 Z9 21 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD OCT PY 2008 VL 90 IS 4 BP 1320 EP 1323 DI 10.1016/j.fertnstert.2007.10.049 PG 4 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 358UQ UT WOS:000259943400072 PM 18249378 ER PT J AU Yauger, BJ Feinberg, EC Levens, ED Gustofson, RL Larsen, FW DeCherney, AH AF Yauger, Belinda J. Feinberg, Eve C. Levens, Eric D. Gustofson, Robert L. Larsen, Frederick W. DeCherney, Alan H. TI Pre-cycle saline infusion sonography minimizes assisted reproductive technologies cycle cancellation due to endometrial polyps SO FERTILITY AND STERILITY LA English DT Editorial Material ID IN-VITRO FERTILIZATION; OFFICE HYSTEROSCOPY; UTERINE; WOMEN; SONOHYSTEROGRAPHY; INFERTILITY; WORK; IVF AB Pre-ART cycle screening with saline infusion sonohysterography is effective at limiting cycle cancellation caused by endometrial polyps to 0.5%. Although a thickened lining at the time of baseline ultrasound can be indicative of a uterine polyp, a normal endometrial lining does not eliminate the possibility that a polyp will be discovered during the cycle. C1 [Yauger, Belinda J.; Feinberg, Eve C.; Levens, Eric D.; Gustofson, Robert L.; Larsen, Frederick W.; DeCherney, Alan H.] NICHHD, Reprod Biol & Branch, NIH, Bethesda, MD 20892 USA. [Yauger, Belinda J.; Feinberg, Eve C.; Levens, Eric D.; Gustofson, Robert L.; Larsen, Frederick W.; DeCherney, Alan H.] NIH, Walter Reed Army Med Ctr, Natl Naval Med Ctr, Bethesda, MD 20892 USA. [Yauger, Belinda J.; Feinberg, Eve C.; Levens, Eric D.; Gustofson, Robert L.; Larsen, Frederick W.; DeCherney, Alan H.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Yauger, Belinda J.; Feinberg, Eve C.; Levens, Eric D.; Gustofson, Robert L.; Larsen, Frederick W.; DeCherney, Alan H.] Walter Reed Army Med Ctr, Assisted Reprod Technol Program, Washington, DC 20307 USA. RP DeCherney, AH (reprint author), NICHHD, Reprod Biol & Branch, NIH, 10 Ctr Dr MSC 1109,Bldg 10,CRC,1-3140, Bethesda, MD 20892 USA. EM decherna@mail.nih.gov NR 18 TC 4 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD OCT PY 2008 VL 90 IS 4 BP 1324 EP 1326 DI 10.1016/j.fertnstert.2007.09.050 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 358UQ UT WOS:000259943400073 PM 18155202 ER PT J AU Asfaw, A AF Asfaw, Abay TI Fruits and vegetables availability for human consumption in Latin American and Caribbean countries: Patterns and determinants SO FOOD POLICY LA English DT Article DE fruit and vegetable availability; fruit and vegetable intake; Latin America; chronic disease; panel data; stationarity ID EUROPEAN COUNTRIES; ENERGY DENSITY; FOOD-INTAKE; LIFE-STYLE; CHILDREN; TELEVISION; VALIDITY; GENDER; IMPACT; EAT AB Inadequate intake of fruits and vegetables (F&V) is one of the leading causes of chronic diseases in the world. This study examined the patterns and determinants of F&V availability for human consumption in Latin American and Caribbean countries between 1991 and 2002. The results showed that there were considerable disparities between and within countries and only one-third of the sampled countries (if only 20% wastage is assumed) could achieve the World Health Organization's recommendation of 146 kg of F&V intake/capita/year. The elasticities estimated from a fixed effect regression also showed that income, urbanization, price, and poverty were some of the important factors that affect the long-term availability of F&V. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Asfaw, Abay] World Bank, PREM Gender & Dev & MENA Social & Econ Dev Grp, Washington, DC 20433 USA. [Asfaw, Abay] USA, Washington, DC 20006 USA. [Asfaw, Abay] Int Food Policy Res Inst, Food Consumpt & Nutr Div, Washington, DC 20006 USA. RP Asfaw, A (reprint author), World Bank, PREM Gender & Dev & MENA Social & Econ Dev Grp, 1818 H St NW, Washington, DC 20433 USA. EM agetahun@worldbank.org NR 56 TC 11 Z9 11 U1 4 U2 11 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0306-9192 J9 FOOD POLICY JI Food Policy PD OCT PY 2008 VL 33 IS 5 BP 444 EP 454 DI 10.1016/j.foodpol.2008.01.007 PG 11 WC Agricultural Economics & Policy; Economics; Food Science & Technology; Nutrition & Dietetics SC Agriculture; Business & Economics; Food Science & Technology; Nutrition & Dietetics GA 351NJ UT WOS:000259430700007 ER PT J AU Butler, RN Hayflick, L Austad, S Olshansky, S Weindruch, R AF Butler, R. N. Hayflick, L. Austad, S. Olshansky, S. Weindruch, R. TI "CAN HUMAN AGING BE SLOWED?" SO GERONTOLOGIST LA English DT Meeting Abstract C1 [Butler, R. N.] USA, Int Longev Ctr, New York, NY USA. [Hayflick, L.] Univ Calif San Francisco, The Sea Ranch, CA USA. [Austad, S.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. [Olshansky, S.] Univ Illinois, Chicago, IL USA. [Weindruch, R.] Univ Wisconsin, Sch Med, Madison, WI USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 EI 1758-5341 J9 GERONTOLOGIST JI Gerontologist PD OCT PY 2008 VL 48 SI 3 BP 113 EP 113 PG 1 WC Gerontology SC Geriatrics & Gerontology GA 399PA UT WOS:000262810600391 ER PT J AU Choi, J Johantgen, M Lang, G AF Choi, J. Johantgen, M. Lang, G. TI SUPERVISORY SUPPORT, JOB SATISFACTION, AND WORKPLACE ENVIRONMENT AMONG NURSING ASSISTANTS IN NURSING HOMES SO GERONTOLOGIST LA English DT Meeting Abstract C1 [Choi, J.; Johantgen, M.] Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA. [Lang, G.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0016-9013 EI 1758-5341 J9 GERONTOLOGIST JI Gerontologist PD OCT PY 2008 VL 48 SI 3 BP 482 EP 482 PG 1 WC Gerontology SC Geriatrics & Gerontology GA 399PA UT WOS:000262810601718 ER PT J AU Nindl, BC Pierce, JR Durkot, MJ Tuckow, AP Kennett, MJ Nieves, JW Cosman, F Alemany, JA Hymer, WC AF Nindl, B. C. Pierce, J. R. Durkot, M. J. Tuckow, A. P. Kennett, M. J. Nieves, J. W. Cosman, F. Alemany, J. A. Hymer, W. C. TI Relationship between growth hormone in vivo bioactivity, the insulin-like growth factor-I system and bone mineral density in young, physically fit men and women SO GROWTH HORMONE & IGF RESEARCH LA English DT Article DE bioassay; hormones; insulin-like growth factor-I binding proteins; pQCT ID GENDER-DIFFERENCES; BINDING-PROTEINS; ASSOCIATION; RELEASE; HETEROGENEITY; EXERCISE AB Context: Bone mineral density (BMD) is influenced by growth factors, such as growth hormone (CH) and insulin-like growth factor-I (IGF-I). The in vivo bioassay for GH (bioGH) provides a more physiologically relevant measurement than an in vitro immunoassay, since bioGH is quantified on a biological outcome. Objective: To determine if bioGH and components of the IGF-I system were associated with BMD in age-matched men (M; n = 41, 19.1 +/- 0.2 year. 70 +/- 3 kg, 163 +/- 125 cm) and women (W; n = 39, 18.6 +/- 0.3 year, 66 +/- 3 kg, 141 +/- 15 cm). Design: Blood was analyzed for growth-related hormones [bioGH, immunoreactive growth hormone (iGH), IGF-I and associated binding proteins], and BMD was measured by pDXA, pQCT, and central DXA (spine, hip). For the bioGH assay, hypophysectomizied female Sprague-Dawley rats were injected with a s.c. bolus of either a GH standard or unknown (each subject's plasma) in four daily injections. The tibia was then examined for epiphyseal growth plate width from which bioGH concentrations were extrapolated. Results: M had greater (P < 0.05) calcaneal BMD when measured by pDXA (M: 1.27 +/- 0.02; W: 1.14 +/- 0.02 g/cm(2)), while pQCT-assessed BMD at the tibia was not different (M: 777 16; W: 799 +/- 16 g/cm(2)). bioGH was similar between M (5388 +/- 800 mu g/L) and W (4282 +/- 643 mu g/L) and was not correlated with BMD. The only BMD-related biomarkers in women were acid-labile subunit (ALS; r = 0.40) and IGFBP-3 (r = 0.42) with DXA-measured spine and femoral neck BM D, and ALS (r = 0.47) with pQCT-assessed tibial BMD and cortical thickness, respectively. Conclusion: Although bioGH was not associated with BMD, IGF-I and associated binding proteins (IGFBP-3 and ALS) emerged as correlates in W only. Published by Elsevier Ltd. C1 [Nindl, B. C.; Pierce, J. R.; Durkot, M. J.; Tuckow, A. P.; Alemany, J. A.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Kennett, M. J.; Hymer, W. C.] Penn State Univ, Cent Biol Lab, State Coll, PA USA. [Nieves, J. W.; Cosman, F.] Helen Hayes Hosp, Clin Res & Reg Bone Ctr, W Haverstraw, NY USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Bradley.Nindl@na.amedd.army.mil FU Medical Research and Materiel Command; Bone Health and Military Readiness [1791853] FX This study was funded, in part, by an In-house laboratory independent research grant from the Medical Research and Materiel Command (to BCN and MJD) and a grant from a Bone Health and Military Readiness grant, (USAMRMC DAM 1) #17918539 to JWN and FC). NR 20 TC 11 Z9 12 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 1096-6374 J9 GROWTH HORM IGF RES JI Growth Horm. IGF Res. PD OCT PY 2008 VL 18 IS 5 BP 439 EP 445 DI 10.1016/j.ghir.2008.03.004 PG 7 WC Cell Biology; Endocrinology & Metabolism SC Cell Biology; Endocrinology & Metabolism GA 339ZA UT WOS:000258614600010 PM 18482854 ER PT J AU Harrison, SA Oliver, D Arnold, HL Gogia, S Neuschwander-Tetri, BA AF Harrison, S. A. Oliver, D. Arnold, H. L. Gogia, S. Neuschwander-Tetri, B. A. TI Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease SO GUT LA English DT Article ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; NATURAL-HISTORY; METABOLIC SYNDROME; OBESE-PATIENTS; HETEROZYGOUS HYPOBETALIPOPROTEINEMIA; ASYMPTOMATIC PATIENTS; HEPATIC STEATOSIS; SEVERELY OBESE AB Background: Clinical predictors of advanced non-alcoholic liver disease (NAFLD) are needed to guide diagnostic evaluation and treatment. Methods: To better understand the demographics of NAFLD and risk factors for advanced disease, this study analysed 827 patients with NAFLD at two geographically separate tertiary medical centres. Results: The cohort was 51% female and had a median body mass index (BMI) of 33 kg/m(2); 3% had a normal BMI. Common co-morbidities included hypertension (60%) and diabetes (35%); insulin resistance was present in 91% and advanced fibrosis in 24% of patients. When comparing patients with no fibrosis or mild fibrosis to those with advanced fibrosis, BMI >= 28 kg/m(2), age > 50 years, and aspartate transaminase/alanine aminotransferase (AST/ALT) ratio >= 0.8, a quantitative assessment check index (QUICKI) score < 0.294 ( equivalent to homeostatasis model assessment (HOMA) > 6.2) and the presence of diabetes mellitus (DM) were individually associated by univariate analysis with odds ratios (ORs) of >= 2.4 for advanced fibrosis. Based on the results of forced entry logistic regression analysis, three variables were combined in a weighted sum ( BMI >= 28= 1 point, AAR of >= 0.8= 2 points, DM= 1 point) to form an easily calculated composite score for predicting advanced fibrosis called the BARD score. A score of 2-4 was associated with an OR for advanced fibrosis of 17 (confidence interval 9.2 to 31.9) and a negative predictive value of 96%. Conclusions: Insulin resistance and its co-morbidities are often present in patients with NAFLD. An easily calculated score based on readily available clinical data can reliably exclude the presence of advanced fibrosis in these patients, particularly among non-diabetics. C1 [Harrison, S. A.; Arnold, H. L.] Brooke Army Med Ctr, Div Gastroenterol & Hepatol, San Antonio, TX USA. [Oliver, D.; Gogia, S.; Neuschwander-Tetri, B. A.] St Louis Univ, Dept Internal Med, St Louis, MO 63103 USA. [Neuschwander-Tetri, B. A.] St Louis Univ, Ctr Liver, St Louis, MO 63103 USA. St Louis Univ, Div Gastroenterol & Hepatol, St Louis, MO 63103 USA. RP Harrison, SA (reprint author), 3841 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Harrison@amedd.army.mil NR 43 TC 239 Z9 243 U1 1 U2 8 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0017-5749 J9 GUT JI Gut PD OCT PY 2008 VL 57 IS 10 BP 1441 EP 1447 DI 10.1136/gut.2007.146019 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 348GK UT WOS:000259198800023 PM 18390575 ER PT J AU Brady, DE An, JW Lawitz, EJ Harrison, S AF Brady, Daniel E. An, Jong W. Lawitz, Eric J. Harrison, Stephen TI DOES INDUCTION PEGYLATED INTERFERON ALFA-2B IN COMBINATION WITH RIBAVIRIN ENHANCE THE SUSTAINED RESPONSE RATES IN PATIENTS WITH GENOTYPE 1 AND 4 CHRONIC HEPATITIS C? RESULTS FROM A PROSPECTIVE, RANDOMIZED, MULTI-CENTER, OPEN-LABEL TREATMENT STUDY SO HEPATOLOGY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 31-NOV 04, 2008 CL San Francisco, CA SP Amer Assoc Study Liver Dis, Moscone West Convent Ctr C1 [Brady, Daniel E.; An, Jong W.; Harrison, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. [Lawitz, Eric J.] Alamo Med Res, San Antonio, TX USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2008 VL 48 IS 4 SU S MA 208 BP 402A EP 402A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 356CX UT WOS:000259757400205 ER PT J AU Williams, CD Stengel, JZ Asike, MI Harrison, S AF Williams, Christopher D. Stengel, Joel Z. Asike, Michael I. Harrison, Stephen TI A PROSPECTIVE PREVALENCE STUDY OF NAFLD AND NASH UTILIZING ULTRASOUND AND LIVER BIOPSY IN A PRIMARY CARE SETTING SO HEPATOLOGY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 31-NOV 04, 2008 CL San Francisco, CA SP Amer Assoc Study Liver Dis, Moscone West Convent Ctr C1 [Williams, Christopher D.; Stengel, Joel Z.; Asike, Michael I.; Harrison, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2008 VL 48 IS 4 SU S MA 1133 BP 812A EP 812A PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 356CX UT WOS:000259757401514 ER PT J AU Mills, SJ Naus, RJ Barstow, K Harrison, S AF Mills, Shane J. Naus, Rhonda J. Barstow, Karol Harrison, Stephen TI VIRAL KINETIC RESPONSE TO 12 WEEK TREATMENT WITH ROSIGILITAZONE IN CHRONIC HEPATITIS C, GENOTYPE 1 PATIENTS WHO ARE PREVIOUS RELAPSERS OR NONRESPONDERS TO PEGYLATED INTERFERON AND RIBAVIRIN SO HEPATOLOGY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases CY OCT 31-NOV 04, 2008 CL San Francisco, CA SP Amer Assoc Study Liver Dis, Moscone West Convent Ctr C1 [Mills, Shane J.; Naus, Rhonda J.; Barstow, Karol; Harrison, Stephen] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 2008 VL 48 IS 4 SU S MA 1870 BP 1145A EP 1146A PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 356CX UT WOS:000259757402546 ER PT J AU DeRosa, C Furusato, B Chen, Y Ravindranath, L Cook, C Cullen, J McLeod, D Srivastava, S Petrovics, G Sesterhenn, I AF DeRosa, C. Furusato, B. Chen, Y. Ravindranath, L. Cook, C. Cullen, J. McLeod, D. Srivastava, S. Petrovics, G. Sesterhenn, I. TI Elevated secreted protein, acidic, and rich in cysteine (SPARC) mRNA expression in neoplastic prostate epithelial cells correlates with PSA recurrence after radical prostatectomy SO HISTOPATHOLOGY LA English DT Meeting Abstract CT 27th International Congress of the International-Academy-of-Pathology CY OCT 12-17, 2008 CL Athens, GREECE SP Int Acad Pathol C1 Ctr Prostate Dis Res, Rockville, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0309-0167 J9 HISTOPATHOLOGY JI Histopathology PD OCT PY 2008 VL 53 MA 630 BP 275 EP 275 PG 1 WC Cell Biology; Pathology SC Cell Biology; Pathology GA 352VF UT WOS:000259524800631 ER PT J AU Furusato, B Gao, C Petrovics, G Brassell, S McLeod, DG Srivastava, S Sesterhenn, IA AF Furusato, B. Gao, C. Petrovics, G. Brassell, S. McLeod, D. G. Srivastava, S. Sesterhenn, I. A. TI Association of TMPRSS2-ERG gene fusion status and prostate epithelial cell markers SLC45A3 and PSA in clinically localized prostate cancer: gene fusion may functionally dedifferentiate the cancer cell in the subset of prostate cancer SO HISTOPATHOLOGY LA English DT Meeting Abstract CT 27th International Congress of the International-Academy-of-Pathology CY OCT 12-17, 2008 CL Athens, GREECE SP Int Acad Pathol C1 [Furusato, B.; Gao, C.; Petrovics, G.; Brassell, S.; McLeod, D. G.; Srivastava, S.] Uniformed Serv Univ Hlth Sci, Dept Surg, Ctr Prostate Dis Res, Bethesda, MD 20814 USA. [Brassell, S.; McLeod, D. G.] Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0309-0167 J9 HISTOPATHOLOGY JI Histopathology PD OCT PY 2008 VL 53 MA 631 BP 275 EP 275 PG 1 WC Cell Biology; Pathology SC Cell Biology; Pathology GA 352VF UT WOS:000259524800632 ER PT J AU Mwamukonda, KB Furusato, B Sesterhenn, IA Chen, Y McLeod, DG AF Mwamukonda, K. B. Furusato, B. Sesterhenn, I. A. Chen, Y. McLeod, D. G. TI Lymphatic invasion in pathologic stage T3 radical prostatectomy specimens as a predictor of biochemical progression SO HISTOPATHOLOGY LA English DT Meeting Abstract CT 27th International Congress of the International-Academy-of-Pathology CY OCT 12-17, 2008 CL Athens, GREECE SP Int Acad Pathol C1 [Mwamukonda, K. B.; McLeod, D. G.] Walter Reed Army Med Ctr, Dept Urol, Washington, DC 20307 USA. [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Washington, DC 20306 USA. [Furusato, B.; Chen, Y.; McLeod, D. G.] Ctr Prostate Dis Res, Rockville, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PUBLISHING, INC PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0309-0167 J9 HISTOPATHOLOGY JI Histopathology PD OCT PY 2008 VL 53 MA 646 BP 282 EP 282 PG 1 WC Cell Biology; Pathology SC Cell Biology; Pathology GA 352VF UT WOS:000259524800647 ER PT J AU Vehadis, V McNutt, T Snook, M Hearne, H Potyraj, P Scozzie, C AF Vehadis, V. McNutt, T. Snook, M. Hearne, H. Potyraj, P. Scozzie, C. TI A 1680-V (at 1 mA/cm(2)) 54-a (at 780 W/cm(2)) normally ON4H-SiC JFET with 0.143-cm(2) active area SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE high current; high power; high voltage; JFET; large area; normally ON; vertical channel; 4H-SiC ID JUNCTION DIODES; PERFORMANCE AB A high-voltage normally ON 4H-SiC vertical junction field-effect transistor (VJFET) of 0.143-cm(2) active area was manufactured in seven photolithographic levels with no epitaxial regrowth and with a single masked ion-implantation event. The VJFET exhibits low gate-to-source p-n-junction leakage current with relatively sharp onset of breakdown. At a drain-current density of 1 mA/cm(2), the VJFET blocks 1680 V at a gate bias of -24 V. A self-aligned floating guard-ring structure provides edge termination that blocks 77% of the 11.8-mu m SiC drift layer's limit. At a gate bias of 2.5 V and a corresponding gate current of 2 mA, the VJFET outputs 53.6 A (375 A/cm(2)) at a forward drain voltage drop of 2.08 V (780 W/cm(2)). The transistor current gain is I-D/I-G = 26 800, and the specific ON-state resistance is 5.5 m Omega . cm(2). To our best knowledge, this is the largest area SiC vertical-channel JFET reported to date and outputs more drain current than any 1200-V class vertical-channel JFET under identical heat-load and gate biasing conditions. C1 [Vehadis, V.; McNutt, T.; Snook, M.; Hearne, H.; Potyraj, P.] Northrop Grumman Elect Syst, Adv Technol Lab, Linthicum, MD 21090 USA. [Scozzie, C.] USA, Res Lab, Adelphi, MD 20783 USA. RP Vehadis, V (reprint author), Northrop Grumman Elect Syst, Adv Technol Lab, Linthicum, MD 21090 USA. EM victor.veliadis@ngc.com; ty.incnutt@ngc.com; megan.snook@ngc.com; harold.hearne@ngc.com; paul.potyraj@ngc.com; sscozzie@arl.army.mil FU U.S. Army Research Laboratory FX Manuscript received June 3, 2008; revised July 10, 2008. First published September 9, 2008; current version published September 24, 2008. This work was supported by the U.S. Army Research Laboratory and was accomplished under Cooperative Agreement W911NF-06-2-0002. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the U.S. Army Research Laboratory or the U.S. Government. The U.S. Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation hereon. The review of this letter was arranged by Editor S.-H. Ryu. NR 7 TC 27 Z9 30 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD OCT PY 2008 VL 29 IS 10 BP 1132 EP 1134 DI 10.1109/LED.2008.2002907 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 356YG UT WOS:000259812900015 ER PT J AU Celik, M Shekhar, S Rogers, JP Shine, JA AF Celik, Mete Shekhar, Shashi Rogers, James P. Shine, James A. TI Mixed-drove spatiotemporal co-occurrence pattern mining SO IEEE TRANSACTIONS ON KNOWLEDGE AND DATA ENGINEERING LA English DT Article DE spatiotemporal data mining; spatiotemporal co-occurrence pattern mining; composite interest measure; mixed-drove spatiotemporal co-occurrence pattern AB Mixed-drove spatiotemporal co-occurrence patterns (MDCOPs) represent subsets of two or more different object-types whose instances are often located in spatial and temporal proximity. Discovering MDCOPs is an important problem with many applications such as identifying tactics in battlefields and games and tracking predator-prey interactions. However, mining MDCOPs is computationally very expensive because the interest measures are computationally complex, data sets are larger due to the archival history, and the set of candidate patterns is exponential in the number of object-types. We propose a monotonic composite interest measure for discovering MDCOPs and novel MDCOP mining algorithms. Analytical results show that the proposed algorithms are correct and complete. Experimental results also show that the proposed methods are computationally more efficient than naive alternatives. C1 [Celik, Mete; Shekhar, Shashi] Univ Minnesota, Dept Comp Sci & Engn, Minneapolis, MN 55455 USA. [Rogers, James P.; Shine, James A.] USA, Ctr Res Dev & Engn, Topog Engn Ctr, Alexandria, VA 22315 USA. RP Celik, M (reprint author), Univ Minnesota, Dept Comp Sci & Engn, 4-192 EE CS Bldg,200 Union St SE, Minneapolis, MN 55455 USA. EM mcelik@cs.umn.edu; shekhar@cs.umn.edu; james.p.rogers.II@usace.army.mil; James.A.Shine@usace.army.mil FU US Army Corps of Engineers [W9132V-06-C-0011]; US National Science Foundation (NSF) [0431141]; NSF [0708604, 0713214]; NGA FX The authors would like to thank the members of the Spatial Database and Spatial Data Mining Research Group at the University of Minnesota for their comments. They would also like to express their thanks to Kim Koffolt for improving the readability of this paper. This work was partially supported by the US Army Corps of Engineers under Contract W9132V-06-C-0011, the US National Science Foundation (NSF) Grant 0431141, the NSF Grant 0708604, the NSF Grant 0713214, and an NGA grant. NR 30 TC 12 Z9 13 U1 1 U2 4 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1041-4347 J9 IEEE T KNOWL DATA EN JI IEEE Trans. Knowl. Data Eng. PD OCT PY 2008 VL 20 IS 10 BP 1322 EP 1335 DI 10.1109/TKDE.2008.97 PG 14 WC Computer Science, Artificial Intelligence; Computer Science, Information Systems; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 348DY UT WOS:000259192400003 ER PT J AU Tsakonas, EE Sidiropoulos, ND Swami, A AF Tsakonas, Efthimios E. Sidiropoulos, Nicholas D. Swami, Ananthram TI Optimal particle filters for tracking a time-varying harmonic or chirp signal SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE carrier frequency offset; chirp; Doppler; particle filtering; polynomial phase; radar; time-frequency analysis; time-varying harmonic; tracking ID STATE ESTIMATION AB We consider the problem of tracking the time-varying (TV) parameters of a harmonic or chirp signal using particle filtering (PF) tools. Similar to previous PF approaches to TV spectral analysis, we assume that the model parameters (complex amplitude, frequency, and frequency rate in the chirp case) evolve according to a Gaussian AR(1) model; but we concentrate on the important special case of a single TV harmonic or chirp. We show that the optimal importance function that minimizes the variance of the particle weights can be computed in closed form, and develop procedures to draw samples from it. We further employ Rao-Blackwellization to come up with reduced-complexity versions of the optimal filters. The end result is custom PF solutions that are considerably more efficient than generic ones, and can be used in a broad range of important applications that involve a single TV harmonic or chirp signal, e.g., TV Doppler estimation in communications, and radar. C1 [Tsakonas, Efthimios E.; Sidiropoulos, Nicholas D.] Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Greece. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Tsakonas, EE (reprint author), Tech Univ Crete, Dept Elect & Comp Engn, Khania 73100, Greece. EM etsakwnas@gmail.com; nikos@telecom.tuc.gr; a.swami@ieee.org NR 21 TC 13 Z9 13 U1 1 U2 10 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD OCT PY 2008 VL 56 IS 10 BP 4598 EP 4610 DI 10.1109/TSP.2008.927462 PN 1 PG 13 WC Engineering, Electrical & Electronic SC Engineering GA 351EM UT WOS:000259407300005 ER PT J AU Ying, YQ Ghogho, M Swami, A AF Ying, Yeqiu Ghogho, Mounir Swami, Ananthram TI Code-assisted synchronization for UWB-IR systems: Algorithms and analysis SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article; Proceedings Paper CT IEEE International Conference on Communications (ICC 2006) CY JUN 11-15, 2006 CL Istanbul, TURKEY SP IEEE DE impulse radio (IR); synchronization; timing offset estimation; ultra-wideband (UWB) ID BAND IMPULSE RADIOS; BER SENSITIVITY; CHANNELS; PERFORMANCE; SIGNALS; ACCESS AB Timing synchronization is a critical challenge in ultra-wideband impulse radios (UWB-IRs). Conventional full-digital synchronization methods encounter implementation difficulties such as high rate sampling and complex RAKE structures. To avoid these challenges, we propose a code-assisted blind synchronization (CABS) algorithm which can also be implemented in a semianalog method. CABS algorithm relies on the discriminative nature of both the time hopping code and a well-designed polarity code, and the challenging channel estimation can be bypassed during the synchronization phase. In the proposed implementation, the algorithm only requires symbol-rate sampling. The performance of CABS is evaluated, both analytically and numerically, and a data-aided variant of the algorithm is also proposed. C1 [Ying, Yeqiu; Ghogho, Mounir] Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Ying, YQ (reprint author), Univ Leeds, Sch Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England. EM y.q.ying03@leeds.ac.uk; m.ghogho@leeds.ac.uk; a.swami@ieee.org NR 26 TC 10 Z9 11 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD OCT PY 2008 VL 56 IS 10 BP 5169 EP 5180 DI 10.1109/TSP.2008.929124 PN 2 PG 12 WC Engineering, Electrical & Electronic SC Engineering GA 351EN UT WOS:000259407400016 ER PT J AU Anandkumar, A Tong, L Swami, A AF Anandkumar, Animashree Tong, Lang Swami, Ananthram TI Optimal node density for detection in energy-constrained random networks SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article; Proceedings Paper CT 45th Annual Allerton Conference on Communication, Control and Computing CY SEP, 2007 CL Monticello, IL DE distributed detection; error exponent; Gauss-Markov random fields (GMRF); routing; sensor networks ID SENSOR NETWORKS; TREES AB The problem of optimal node density maximizing the Neyman-Pearson detection error exponent subject to a constraint on average (per node) energy consumption is analyzed. The spatial correlation among the sensor measurements is incorporated through a Gauss-Markov random field (GMRF) model with Euclidean nearest-neighbor dependency graph. A constant density deployment of sensors under the uniform or Poisson distribution is assumed. It is shown that the optimal node density crucially depends on the ratio between the measurement variances under the two hypotheses and displays a threshold behavior. Below the threshold value of the variance ratio, the optimal node density tends to infinity under any feasible average energy constraint. On the other hand, when the variance ratio is above the threshold, the optimal node density is the minimum value at which it is feasible to process and deliver the likelihood ratio (sufficient statistic) of the sensor measurements to the fusion center. In this regime of the variance ratio, an upper bound on the optimal node density based on a proposed 2-approximation fusion scheme and a lower bound based on the minimum spanning tree are established. Under an alternative formulation where the energy consumption per unit area is constrained, the optimal node density is shown to be strictly finite for all values of the variance ratio and bounds on this optimal node density are provided. C1 [Anandkumar, Animashree; Tong, Lang] Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. [Swami, Ananthram] USA, Res Lab, Adelphi, MD 20783 USA. RP Anandkumar, A (reprint author), Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. EM aa332@cor-nell.edu; ltong@ece.cornell.edu; a.swami@ieee.org NR 41 TC 11 Z9 12 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-587X EI 1941-0476 J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD OCT PY 2008 VL 56 IS 10 BP 5232 EP 5245 DI 10.1109/TSP.2008.928514 PN 2 PG 14 WC Engineering, Electrical & Electronic SC Engineering GA 351EN UT WOS:000259407400021 ER PT J AU Kurnick, M Coleman, BR Nambiar, MP AF Kurnick, M. Coleman, B. R. Nambiar, M. P. TI [ plus ]-Huperzine A acts by NMDA receptor antagonism and protects against diisoprpyl-fluorophosphate induced seizure/status epilepticus in rats SO INDIAN JOURNAL OF PHARMACOLOGY LA English DT Meeting Abstract C1 [Kurnick, M.; Coleman, B. R.; Nambiar, M. P.] Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MEDKNOW PUBLICATIONS PI MUMBAI PA A-108-109 KANARA BUSINESS CENTRE, GHAKTOPAR, MUMBAI, 400075, INDIA SN 0253-7613 J9 INDIAN J PHARMACOL JI Indian J. Pharmacol. PD OCT PY 2008 VL 40 MA 579 BP 202 EP 202 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 429MJ UT WOS:000264924200579 ER PT J AU Nambiar, MP Sciuto, AM AF Nambiar, M. P. Sciuto, A. M. TI Nasal therapeutics to medical countermeasure against inhalation exposure to chemical warfare nerve agents SO INDIAN JOURNAL OF PHARMACOLOGY LA English DT Meeting Abstract C1 [Nambiar, M. P.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Sciuto, A. M.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MEDKNOW PUBLICATIONS PI MUMBAI PA A-108-109 KANARA BUSINESS CENTRE, GHAKTOPAR, MUMBAI, 400075, INDIA SN 0253-7613 J9 INDIAN J PHARMACOL JI Indian J. Pharmacol. PD OCT PY 2008 VL 40 MA 581 BP 202 EP 202 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 429MJ UT WOS:000264924200581 ER PT J AU Sutton, TL Zhao, AP Madden, KB Elfrey, JE Tuft, BA Sullivan, CA Urban, JF Shea-Donohue, T AF Sutton, Thomas L. Zhao, Aiping Madden, Kathleen B. Elfrey, Justin E. Tuft, Blaine A. Sullivan, Carolyn A. Urban, Joseph F., Jr. Shea-Donohue, Terez TI Anti-inflammatory mechanisms of enteric Heligmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model SO INFECTION AND IMMUNITY LA English DT Article ID PROTEINASE-ACTIVATED RECEPTOR-2; HISTAMINE H-4 RECEPTOR; EPITHELIAL-CELL FUNCTION; INTESTINAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; TRICHURIS-SUIS THERAPY; GUINEA-PIG COLON; CD8+ T-CELLS; CROHNS-DISEASE; MOLECULAR-CLONING AB Recent studies showed that enteric helminth infection improved symptoms in patients with inflammatory bowel disease as well as in experimental models of colitis. The aim of this study was to determine the mechanism of the protective effect of helminth infection on colitis-induced changes in immune and epithelial cell function. BALB/c mice received an oral infection of Heligmosomoides polygyrus third-stage larvae, were given intrarectal saline or trinitrobenzene sulfonic acid (TNBS) on day 10 postinfection, and were studied 4 days later. Separate groups of mice received intrarectal saline or TNBS on day 10 and were studied on day 14. Muscle-free colonic mucosae were mounted in Ussing chambers to measure mucosal permeability and secretion. Expression of cytokines was assessed by quantitative real-time PCR, and mast cells were visualized by immunohistochemistry. TNBS-induced colitis induced mucosal damage, upregulated Th1 cytokines, and depressed secretory responses. Heligmosomoides polygyrus elevated Th2 cytokine expression, increased mast cell infiltration and mucosal resistance, and also reduced some secretory responses. Prior H. polygyrus infection prevented TNBS-induced upregulation of Th1 cytokines and normalized secretory responses to specific agonists. TNBS-induced colitis did not alter H. polygyrus-induced mast cell infiltration or upregulation of Th2 cytokine expression. The results indicate that the protective mechanism of enteric nematode infection against TNBS-induced colitis involves prevention of Th1 cytokine expression and improved colonic function by a mechanism that may involve mast cell-mediated protection of neural control of secretory function. Similar response patterns could account for the clinical improvement seen in inflammatory bowel disease with helminthic therapy. C1 [Sutton, Thomas L.; Tuft, Blaine A.; Sullivan, Carolyn A.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Zhao, Aiping; Elfrey, Justin E.; Shea-Donohue, Terez] Univ Maryland, Sch Med, Mucosal Biol Res Ctr, Baltimore, MD 21201 USA. [Zhao, Aiping; Elfrey, Justin E.; Shea-Donohue, Terez] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA. [Madden, Kathleen B.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Urban, Joseph F., Jr.] USDA ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA. RP Shea-Donohue, T (reprint author), Univ Maryland, Sch Med, Mucosal Biol Res Ctr, 20 Penn St, Baltimore, MD 21201 USA. EM tdonohue@mbrc.umaryland.edu OI Urban, Joseph/0000-0002-1590-8869 NR 66 TC 34 Z9 34 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD OCT PY 2008 VL 76 IS 10 BP 4772 EP 4782 DI 10.1128/IAI.00744-07 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 349PM UT WOS:000259293100047 PM 18644879 ER PT J AU Moran, KA Murray, CK Anderson, EL AF Moran, Kimberly A. Murray, Clinton K. Anderson, Edwin L. TI Bacteriology of Blood, Wound, and Sputum Cultures from Non-US Casualties Treated in a Combat Support Hospital in Iraq SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID ARMY SOLDIERS; INFECTIONS; COLONIZATION AB A review of culture results from non-US casualties in Iraq revealed gram-negative bacteria were the most commonly isolated pathogens. Cultures of respiratory fluid yielded positive results earlier than cultures of wound or blood samples and potentially serve as an earlier marker of future infections. Continued aggressive infection control for non-US casualties is needed. C1 [Moran, Kimberly A.] USUHS, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. [Murray, Clinton K.] Brooke Army Med Ctr, Dept Med, Infect Dis Serv, Ft Sam Houston, TX 78234 USA. [Anderson, Edwin L.] St Louis Univ, Sch Med, Dept Med, St Louis, MO 63104 USA. RP Moran, KA (reprint author), USUHS, Dept Prevent Med & Biometr, Room A2067,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM ixchel-dc@msn.com NR 10 TC 6 Z9 6 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD OCT PY 2008 VL 29 IS 10 BP 981 EP 984 DI 10.1086/591034 PG 4 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 364DZ UT WOS:000260317700018 PM 18754736 ER PT J AU Chen, WH Kang, TJ Bhattacharjee, AK Cross, AS AF Chen, Wilbur H. Kang, Tae Jin Bhattacharjee, Apurba K. Cross, Alan S. TI Intranasal administration of a detoxified endotoxin vaccine protects mice against heterologous Gram-negative bacterial pneumonia SO INNATE IMMUNITY LA English DT Article DE Sepsis; endotoxin; vaccine; mucosal immunity; pneumonia ID OUTER-MEMBRANE PROTEIN; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; NEISSERIA-MENINGITIDIS; CPG OLIGODEOXYNUCLEOTIDES; ACTIVE IMMUNIZATION; BRUCELLA-MELITENSIS; PULMONARY CLEARANCE; NONCOVALENT COMPLEX; CONJUGATE VACCINE AB When given passively or elicited actively, antibodies induced by a detoxified Escherichia coli J5 mutant lipopolysaccharide (J5dLPS)-group B meningococcal outer membrane protein (-OMP) vaccine previously protected animals from lethal sepsis. To assess the use of this vaccine for the treatment of Gram-negative bacillary pneumonia, we vaccinated mice, with or without the adjuvant CpG, by intranasal (i.n.) or intraperitoneal (i.p.) routes of administration. Local and systemic IgG levels were 2-3 logs higher following i.p. immunization compared to i.n. However, i.n. immunization elicited both local and systemic IgA, unlike i.p. administration. The addition of CpG to the vaccine, by either route of administration, elicited greater levels of antibody. Intranasal immunization protected mice against lethal heterologous Gram-negative bacillary pneumonia and post-immunization serum and bronchoalveolar lavage fluid mediated enhanced bacterial killing with peritoneal and alveolar macrophages in vitro. We conclude that further studies oil the use of J5dLPS-OMP for the prevention of nosocomial pneumonia are warranted. C1 [Chen, Wilbur H.; Kang, Tae Jin; Cross, Alan S.] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA. [Bhattacharjee, Apurba K.] Walter Reed Army Inst Res, Silver Spring, MD USA. RP Chen, WH (reprint author), Univ Maryland, Sch Med, Ctr Vaccine Dev, 685 W Baltimore St,Suite 480, Baltimore, MD 21201 USA. EM wchen@medicine.umaryland.edu FU National Institute of Allergy and Infectious Diseases [RO1AI 42181, T32AI07524]; National Center for Research Resources [K12RR023250] FX The authors thank Dr Jeffrey Hasday for technical assistance with developing the murine pneumonia model for these experiments. This research was supported by National Institute of Allergy and Infectious Diseases grants RO1AI 42181 and T32AI07524 and National Center for Research Resources grant K12RR023250. NR 38 TC 7 Z9 7 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 1753-4259 J9 INNATE IMMUN JI Innate Immun. PD OCT PY 2008 VL 14 IS 5 BP 269 EP 278 DI 10.1177/1753425908095959 PG 10 WC Biochemistry & Molecular Biology; Immunology; Medicine, Research & Experimental; Microbiology SC Biochemistry & Molecular Biology; Immunology; Research & Experimental Medicine; Microbiology GA 371CJ UT WOS:000260809100001 PM 18809651 ER PT J AU Fadare, O Orejudos, MP Jain, R Mariappan, MR Hecht, JL Renshaw, IL Hileeto, D Wang, SA Ghofrani, M Liang, SX AF Fadare, Oluwole Orejudos, Michael P. Jain, Reena Mariappan, M. Rajan Hecht, Jonathan L. Renshaw, Idris L. Hileeto, Denise Wang, Sa A. Ghofrani, Mohiedean Liang, Sharon X. TI A comparative analysis of lymphatic vessel density in ovarian serous tumors of low malignant potential (borderline tumors) with and without lymph node involvement SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY LA English DT Article DE serous; ovarian; ovary; lymph node; borderline; tumors of low malignant potential; D2-40; lymphatic vessel density ID GROWTH FACTOR-C; MULLERIAN INCLUSION CYSTS; FOLLOW-UP; GLANDULAR INCLUSIONS; LYMPHANGIOGENESIS; METASTASIS; MICROINVASION; CANCER; ORIGIN; VEGF AB Lymph node involvement is seen in approximately one quarter of women with surgically staged ovarian serous tumors of low malignant potential (serous borderline tumors), and this finding apparently does not adversely impact their overall survival. To help illuminate some of the pathomechanisms underlying this novel phenomenon, in which a largely noninvasive epithelial neoplasm is able to exit its primary site and be transported to lymph nodes with such a substantial frequency, we investigated whether significant differences in lymphatic vessel density exist between ovarian serous borderline tumors that show lymph node involvement and those that do not. The lymphatic vessel density of 13 conventional ovarian serous borderline tumors (i.e. tumors without stromal microinvasion, micropapillary/cribriform areas, or invasive implants) with at least 1 positive lymph node (study group) was compared with the lymphatic vessel density of an age- and disease extent matched control group of 13 similarly selected lymph node-negative ovarian serous borderline tumors. Lymphatic vessel density was determined by counting the total number of vascular spaces immunohistochemically stained by the lymphatic endothelium marker D2-40 in 5 consecutive microscopic fields ( x 20 objective, field area of 1 microscopic field, 0.95 mm(2)) in the most vessel-dense areas and calculating the average value per microscopic field. The peritumoral lymphatic vessel density was significantly higher than the intratumoral lymphatic vessel density,in both groups. However, no statistically significant differences were found between the study and control groups regarding intratumoral lymphatic vessel density (8.0 vs. 7.61- P=0.77), peritumoral lymphatic vessel density (20.33 vs. 21.0; P=0.79), or combined, that is, peritumoral plus intratumoral lymphatic vessel density (27.81 vs. 28.62; P=0.83). Our findings, in conjunction with others in the medical literature, do not support a role for tumor lymphatics in nodal metastasis in this neoplasm. We discuss the possibility that nodal deposits may represent metastatic disease from secondary tumor implants. C1 [Fadare, Oluwole; Orejudos, Michael P.] Wilford Hall USAF Med Ctr, Dept Pathol, Lackland AFB, TX 78236 USA. [Fadare, Oluwole] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, San Antonio, TX 78229 USA. [Orejudos, Michael P.] San Antonio Uniformed Serv Hlth Educ Consortium, Pathol Program, San Antonio, TX USA. [Orejudos, Michael P.] Brooke Army Med Ctr, Dept Pathol & Lab Serv, Ft Sam Houston, TX 78234 USA. [Jain, Reena] Virginia Commonwealth Univ, Dept Pathol, Richmond, VA USA. [Mariappan, M. Rajan; Hecht, Jonathan L.] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA. [Mariappan, M. Rajan; Hecht, Jonathan L.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA USA. [Mariappan, M. Rajan] Beth Israel Deaconess Med Ctr, Div Matrix Biol, Boston, MA 02215 USA. [Renshaw, Idris L.] Vanguard Pathol Associates, Austin, TX USA. [Hileeto, Denise] McMaster Univ, Dept Pathol, Hamilton, ON, Canada. [Wang, Sa A.] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01605 USA. [Ghofrani, Mohiedean] SW Washington Med Ctr, Dept Pathol, Vancouver, WA USA. [Liang, Sharon X.] SUNY Stony Brook, Med Ctr, Dept Pathol, Stony Brook, NY 11794 USA. RP Fadare, O (reprint author), Wilford Hall USAF Med Ctr, Dept Pathol, 2200 Bergquist Dr,Ste 1, Lackland AFB, TX 78236 USA. EM oluwolefadare@yahoo.com FU NCI NIH HHS [P30 CA016672] NR 44 TC 9 Z9 11 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-1691 J9 INT J GYNECOL PATHOL JI Int. J. Gynecol. Pathol. PD OCT PY 2008 VL 27 IS 4 BP 483 EP 490 DI 10.1097/PGP.0b013e3181742d7c PG 8 WC Obstetrics & Gynecology; Pathology SC Obstetrics & Gynecology; Pathology GA 352QX UT WOS:000259513500003 PM 18753975 ER PT J AU Brown, TM Brouwer, J Samuelsen, GS Holcomb, FH King, J AF Brown, Tim M. Brouwer, Jacob Samuelsen, G. Scott Holcomb, Franklin H. King, Joel TI Accurate simplified dynamic model of a metal hydride tank SO INTERNATIONAL JOURNAL OF HYDROGEN ENERGY LA English DT Article DE Dynamic model; Metal hydride; Hydrogen storage; Reversible fuel cell ID MASS-TRANSFER; HYDROGEN REACTOR; BEDS; HEAT; ABSORPTION AB As proton exchange membrane fuel cell technology advances, the need for hydrogen storage intensifies. metal hydride alloys offer one potential solution. However, for metal hydride tanks to become a viable hydrogen storage option, the dynamic performance of practical tank geometries and configurations must be understood and incorporated into fuel cell system analyses. A dynamic, axially-symmetric, multi-nodal metal hydride tank model has been created in Matlab-Simulink (R) as an initial means of providing insight and analysis capabilities for the dynamic performance of commercially available metal hydride systems. Following the original work of Mayer et al. [Mayer U, Groll M, Supper W. Heat and mass transfer in metal hydride reaction beds: experimental and theoretical results. journal of the Less-Common Metals 1987;131:235-44], this model employs first principles heat transfer and fluid flow mechanisms together with empirically derived reaction kinetics. Energy and mass balances are solved in cylindrical polar coordinates for a cylindrically shaped tank. The model tank temperature, heat release, and storage volume have been correlated to an actual metal hydride tank for static and transient absorption and desorption processes. A sensitivity analysis of the model was accomplished to identify governing physics and to identify techniques to lessen the computational burden for ease of use in a larger system model. The sensitivity analysis reveals the basis and justification for model simplifications that are selected. Results show that the detailed and simplified models both well predict observed stand-alone metal hydride tank dynamics, and an example of a reversible fuel cell system model incorporating each tank demonstrates the need for model simplification. (c) 2008 International Association for Hydrogen Energy. Published by Elsevier Ltd. All rights reserved. C1 [Brown, Tim M.; Brouwer, Jacob; Samuelsen, G. Scott] Univ Calif Irvine, NFCRC, Irvine, CA 92697 USA. [Holcomb, Franklin H.] USA, Engineer Res & Dev Ctr, Champaign, IL 61822 USA. [King, Joel] Alion Sci & Technol, Mclean, VA 22102 USA. RP Brouwer, J (reprint author), Univ Calif Irvine, NFCRC, Irvine, CA 92697 USA. EM jb@nfcrc.uci.edu NR 19 TC 18 Z9 18 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0360-3199 J9 INT J HYDROGEN ENERG JI Int. J. Hydrog. Energy PD OCT PY 2008 VL 33 IS 20 BP 5596 EP 5605 DI 10.1016/j.ijhydene.2008.05.104 PG 10 WC Chemistry, Physical; Electrochemistry; Energy & Fuels SC Chemistry; Electrochemistry; Energy & Fuels GA 373YI UT WOS:000261009000037 ER PT J AU Brietzke, SE Brigger, MT AF Brietzke, Scott E. Brigger, Matthew T. TI Adenoidectomy outcomes in pediatric rhinosinusitis: A meta-analysis SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article; Proceedings Paper CT 22nd Annual Meeting of the American-Society-of-Pediatric-Otolaryngology CY APR 27-29, 2007 CL San Diego, CA SP Amer Soc Pediat Otolaryngol DE Adenoidectomy; Pediatric rhinosinusitis; Otolaryngology; Evidence-based medicine ID CHRONIC SINUSITIS; CHILDREN; MANAGEMENT; EFFICACY AB Objective: To evaluate the currently available literature regarding the reported effectiveness of adenoidectomy alone in the management of medically refractory pediatric chronic rhinosnusitis. Methods: The MEDLINE and EMBASE databases were systematically searched for English language manuscripts reporting on effectiveness of adenoidectomy atone in management of medically refractory pediatric rhinosinusitis. Additional manuscripts were identified by manual searching. Random effects modeling was performed to produce summary estimates of adenoidectomy effectiveness. Results: Nine studies met the inclusion criteria. Six were cohort studies (level 2b) and four were case series (level 4). Mean sample size was 46 subjects (range = 10-121) with grand mean age of 5.8 years (range 4.4-6.9 years). AR studies showed that sinusitis symptoms or outcomes improved in half or more patients after adenoidectomy. Eight studies were sufficiently similar to undergo meta-analysis. The summary estimate of the proportion of patients who significantly improved after adenoidectomy was 69.3% (95% CI = 56.8-81.7%, p < 0.001). The possibility of author bias was explored as one author group contributed a large proportion of patients to the study group. Conclusion: Adenoidectomy reduces caregiver reported symptoms of chronic rhinosinusitis in a majority of pediatric patients. Given its simplicity, tow risk profile, and apparent effectiveness, adenoidectomy should be considered first tine therapy for medically refractory, uncomplicated pediatric rhinosinusitis. Published by Elsevier Ireland Ltd. C1 [Brietzke, Scott E.] Walter Reed Army Med Ctr, Dept Otolaryngol, Washington, DC 20307 USA. [Brigger, Matthew T.] Natl Naval Med Ctr, Dept Otolaryngol, Bethesda, MD USA. RP Brietzke, SE (reprint author), Walter Reed Army Med Ctr, Dept Otolaryngol, 6900 Georgia Ave, Washington, DC 20307 USA. EM SEBrietzke@msn.com NR 11 TC 34 Z9 34 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD OCT PY 2008 VL 72 IS 10 BP 1541 EP 1545 DI 10.1016/j.ijporl.2008.07.008 PG 5 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA 358CQ UT WOS:000259894600013 PM 18723228 ER PT J AU Dooley, Y Lowenstein, L Kenton, K FitzGerald, M Brubaker, L AF Dooley, Yashika Lowenstein, Lior Kenton, Kimberly FitzGerald, MaryPat Brubaker, Linda TI Mixed incontinence is more bothersome than pure incontinence subtypes SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article DE bother; mixed incontinence; quality of life; stress incontinence; urge incontinence ID FEMALE URINARY-INCONTINENCE; QUALITY-OF-LIFE; EPIDEMIOLOGIC SURVEY; STRESS-INCONTINENCE; SEVERITY; WOMEN AB The purpose of the study was to compare incontinence bother in women with mixed incontinence versus pure incontinence subtypes. This is an institutional review board-approved study comparing physical exam findings and responses to the Medical Epidemiologic and Social Aspects of Aging (MESA) questionnaire and the Urinary Distress Inventory (UDI-6). The MESA responses were used to classify women as mixed, pure stress, or pure urge incontinence. This analysis includes 551 women with a mean age of 56 +/- 16 years. Most women were Caucasian (86%) with 7% African American and 5% Hispanic. UDI scores were significantly higher in women with mixed incontinence (61 +/- 23) than those with pure stress incontinence (40 +/- 26) or pure urge incontinence (40 +/- 25; p < 0.0001). Women with mixed incontinence report greater incontinence bother than women with either pure stress or urge incontinence. C1 [Dooley, Yashika] Brooke Army Med Ctr, Dept Obstet & Gynecol, MCHE OG, Ft Sam Houston, TX 78234 USA. Loyola Univ, Med Ctr, Dept Obstet & Gynecol, Div Female Pelv Med & Reconstruct Surg, Maywood, IL 60153 USA. Loyola Univ, Med Ctr, Dept Urol, Div Female Pelv Med & Reconstruct Surg, Maywood, IL 60153 USA. RP Dooley, Y (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, MCHE OG, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM yashika.dooley@amedd.army.mil NR 11 TC 36 Z9 38 U1 1 U2 1 PU SPRINGER LONDON LTD PI LONDON PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND SN 0937-3462 J9 INT UROGYNECOL J JI Int. Urogynecol. J. PD OCT PY 2008 VL 19 IS 10 BP 1359 EP 1362 DI 10.1007/s00192-008-0637-4 PG 4 WC Obstetrics & Gynecology; Urology & Nephrology SC Obstetrics & Gynecology; Urology & Nephrology GA 347LB UT WOS:000259142000006 PM 18491026 ER PT J AU Nelson, LS Shearer, JF AF Nelson, Linda S. Shearer, Judy F. TI Evaluation of Triclopyr and Mycoleptodiscus terrestris for Control of Eurasian Watermilfoil (Myriophyllum spicatum) SO INVASIVE PLANT SCIENCE AND MANAGEMENT LA English DT Article DE Aquatic plant management; fungal pathogen; integrated weed management; invasive species AB Growth chamber studies were conducted using 55-L aquariums to evaluate the efficacy of the herbicide triclopyr and the fungal pathogen Mycoleptodiscus terrestris, applied alone and in combination against Eurasian watermilfoil. Treatments included 0.15, 0.40, and 1.50 mg acid equivalent (ae)/L triclopyr, 0.08, 0.16, and 0.32 ml/L M. terrestris, combinations of both agents at all rates, and an untreated control. Plants were exposed to all treatments for a 24-h contact time and plant biomass (shoot and roots) was recorded 6 wk after application. For both triclopyr and M. terrestris applied alone, plant control increased with treatment concentration. Compared with untreated plants, 1.50 mg/L triclopyr and 0.32 ml/L M. terrestris reduced Eurasian watermilfoil by 100 and 91%, respectively. Lower doses of herbicide or pathogen were less effective and plant recovery was observed from surviving plant tissues (stems and root crowns). Although M. terrestris at 0.08 ml/L did not significantly reduce shoot or root biomass and 0.15 mg/L triclopyr provided only 53% control of plants, combining both agents at these rates reduced Eurasian watermilfoil by 90%. Results demonstrated that integrating low doses of triclopyr with an indigenous pathogen, M. terrestris, can improve control of Eurasian watermilfoil. Lower use rates of triclopyr would minimize impacts to sensitive nontarget vegetation, reduce application costs, and may minimize impacts of label-imposed use restrictions. C1 [Nelson, Linda S.; Shearer, Judy F.] USA, Environm Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Nelson, LS (reprint author), USA, Environm Lab, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Linda.S.Nelson@usace.army.mil FU U.S. Army Corps of Engineers Aquatic Plant Control Research Program FX The authors would like to thank M. Heilman, SePRO Corporation, for supplying the triclopyr formulation (Renovate (TM) 3) used in these studies. This research was funded by the U.S. Army Corps of Engineers Aquatic Plant Control Research Program. Permission was granted by the Chief of Engineers to publish this information. NR 45 TC 4 Z9 4 U1 1 U2 12 PU WEED SCI SOC AMER PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 USA SN 1939-7291 J9 INVAS PLANT SCI MANA JI Invasive Plant Sci. Manag. PD OCT PY 2008 VL 1 IS 4 BP 337 EP 342 DI 10.1614/IPSM-08-080.1 PG 6 WC Plant Sciences SC Plant Sciences GA V25WD UT WOS:000208507200002 ER PT J AU Ananworanich, J Phanuphak, N de Souza, M Paris, R Arroyo, M Trichavaroj, R Sirivichayakul, S Shikuma, C Phanuphak, P Kim, JH AF Ananworanich, Jintanat Phanuphak, Nittaya de Souza, Mark Paris, Robert Arroyo, Miguel Trichavaroj, Rapee Sirivichayakul, Sunee Shikuma, Cecilia Phanuphak, Praphan Kim, Jerome H. CA SE Asia Res Collaboration Hawaii TI Incidence and characterization of acute HIV-1 infection in a high-risk Thai population SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE acute HIV infection; pooled nucleic acid testing; sequential EIA; Fiebig; Thailand ID ANTIRETROVIRAL THERAPY; DRUG-RESISTANCE; VIRUS; DISEASE; PREVALENCE; PREVENTION; PLASMA; TYPE-1; SEX; MEN AB Objective: The objective of this study was to investigate the incidence, demographics, HIV subtype, and genotypic resistance of acute HIV infections in a high-risk Thai population. Methods: Between March 2006 and September 2007, 6426 stored samples at the Thai Red Cross Anonymous Clinic were screened for acute HIV infection by 2 methods: pooled nucleic acid testing (NAT) of fourth-generation enzyme immunoassay (EIA)-negative samples (n = 5402) and subsequent first-generation EIA testing of fourth-generation EIA-positive samples (n = 1024). Results: Eleven acute HIV-infected subjects were identified by pooled NAT (n = 7) and serial EIA (n = 4). Mean age was 28 years; 9 were male; and 60% were men who have sex with men. Median HIV RNA was 99,601 copies per milliliter (log(10) viral load (VL) = 5.00). Eight samples could be genotyped: 6, CRF01_AE; 1, subtype 13; and 1, CRF01_AE/B recombinant. No resistance to antiretroviral therapy was found. The HIV incidence per 100 person-years, calculated from the pooled, antibody-negative samples, was 2.7% (95% confidence interval, 2.2%-4.3%). Conclusions: This is the first report of antibody-negative, NAT-positive. acute HIV infection in Thailand. The majority were men who have sex with men, which reflects the Current epidemic in Thailand and justifies prevention programs aimed at this group. This high-risk population may be suitable for future Studies on acute HIV infection, HIV treatment, vaccine, and prevention of onward transmission strategies. C1 [Ananworanich, Jintanat; de Souza, Mark; Paris, Robert; Arroyo, Miguel; Trichavaroj, Rapee; Kim, Jerome H.] Armed Forces Res Inst Med Sci, Dept Retrovirol, Bangkok 10400, Thailand. [Ananworanich, Jintanat; Shikuma, Cecilia] Univ Hawaii, Dept Med, Honolulu, HI 96822 USA. [Phanuphak, Nittaya; Sirivichayakul, Sunee; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand. [Sirivichayakul, Sunee] Chulalongkorn Univ, Dept Med, Bangkok, Thailand. RP Ananworanich, J (reprint author), SE Asia Res Collaborat Hawaii, 104 Rajdumri Rd, Bangkok 10330, Thailand. EM jintanat.a@searchthailand.org OI Arroyo, Miguel/0000-0001-7416-8867 FU US Army Medical Research and Materiel Command [DAMD17-98-2-7007, W81XWH-07-2-0073] FX Supported by the US Army Medical Research and Materiel Command and its cooperative agreements DAMD17-98-2-7007 and W81XWH-07-2-0073. NR 33 TC 34 Z9 35 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD OCT 1 PY 2008 VL 49 IS 2 BP 151 EP 155 DI 10.1097/QAI.0b013e318183a96d PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 353SB UT WOS:000259587400006 PM 18769355 ER PT J AU Marano, N Plikaytis, BD Martin, SW Rose, C Semenova, VA Martin, SK Freeman, AE Li, H Mulligan, MJ Parker, SD Babcock, J Keitel, W El Sahly, H Poland, GA Jacobson, RM Keyserling, HL Soroka, SD Fox, SP Stamper, JL McNeil, MM Perkins, BA Messonnier, N Quinn, CP AF Marano, Nina Plikaytis, Brian D. Martin, Stacey W. Rose, Charles Semenova, Vera A. Martin, Sandra K. Freeman, Alison E. Li, Han Mulligan, Mark J. Parker, Scott D. Babcock, Janiine Keitel, Wendy El Sahly, Hana Poland, Gregory A. Jacobson, Robert M. Keyserling, Harry L. Soroka, Stephen D. Fox, Sarah P. Stamper, John L. McNeil, Michael M. Perkins, Bradley A. Messonnier, Nancy Quinn, Conrad P. CA Anthrax Vaccine Res Program Workin TI Effects of a reduced dose schedule and intramuscular administration of anthrax vaccine adsorbed on immunogenicity and safety at 7 months - A randomized trial SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID REPORTING SYSTEM VAERS; SIDED TESTS PROCEDURE; PROTECTIVE ANTIGEN; MULTIPLE IMPUTATION; ADVERSE EVENTS; IMMUNOGLOBULIN-G; CORRELATE; IMMUNITY; HUMANS; ROUTE AB Context In 1999, the US Congress directed the Centers for Disease Control and Prevention to conduct a pivotal safety and efficacy study of anthrax vaccine adsorbed ( AVA). Objective To determine the effects on serological responses and injection site adverse events ( AEs) resulting from changing the route of administration of AVA from subcutaneous ( SQ) to intramuscular ( IM) and omitting the week 2 dose from the licensed schedule. Design, Setting, and Participants Assessment of the first 1005 enrollees in a multisite, randomized, double- blind, noninferiority, phase 4 human clinical trial ( ongoing from May 2002). Intervention Healthy adults received AVA by the SQ ( reference group) or IM route at 0, 2, and 4 weeks and 6 months ( 4- SQ or 4- IM; n= 165- 170 per group) or at a reduced 3- dose schedule ( 3- IM; n= 501). A control group ( n= 169) received saline injections at the same time intervals. Main Outcome Measures Noninferiority at week 8 and month 7 of anti protective antigen IgG geometric mean concentration ( GMC), geometric mean titer ( GMT), and proportion of responders with a 4- fold rise in titer (% 4 x R). Reactogenicity outcomes were proportions of injection site and systemic AEs. Results At week 8, the 4- IM group ( GMC, 90.8 mu g/mL; GMT, 1114.8; % 4 x R, 97.7) was noninferior to the 4- SQ group ( GMC, 105.1 mu g/mL; GMT, 1315.4;% 4 x R, 98.8) for all 3 primary end points. The 3- IM group was noninferior for only the % 4 x R ( GMC, 52.2 mu g/mL; GMT, 650.6;% 4 x R, 94.4). At month 7, all groups were noninferior to the licensed regimen for all end points. Solicited injection site AEs assessed during examinations occurred at lower proportions in the 4- IM group compared with 4- SQ. The odds ratio for ordinal end point pain reported immediately after injection was reduced by 50% for the 4- IM vs 4- SQ groups ( P <. 001). Route of administration did not significantly influence the occurrence of systemic AEs. Conclusions The 4- IM and 3- IM regimens of AVA provided noninferior immunological priming by month 7 when compared with the 4- SQ licensed regimen. Intramuscular administration significantly reduced the occurrence of injection site AEs. Trial Registration clinicaltrials. gov Identifier: NCT00119067. C1 [Marano, Nina; Plikaytis, Brian D.; Martin, Stacey W.; Rose, Charles; Semenova, Vera A.; Martin, Sandra K.; Freeman, Alison E.; Li, Han; Soroka, Stephen D.; Fox, Sarah P.; Stamper, John L.; McNeil, Michael M.; Perkins, Bradley A.; Messonnier, Nancy; Quinn, Conrad P.] Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, Atlanta, GA 30333 USA. [Mulligan, Mark J.; Parker, Scott D.] Univ Alabama Birmingham, Birmingham, AL USA. [Babcock, Janiine] Walter Reed Army Inst Res, Silver Spring, MD USA. [Keitel, Wendy; El Sahly, Hana] Baylor Coll Med, Dept Mol Virol, Houston, TX 77030 USA. [Keitel, Wendy; El Sahly, Hana] Baylor Coll Med, Dept Microbiol, Houston, TX 77030 USA. [Keitel, Wendy; El Sahly, Hana] Baylor Coll Med, Dept Med, Houston, TX 77030 USA. [Poland, Gregory A.; Jacobson, Robert M.] Mayo Clin, Rochester, MN USA. [Keyserling, Harry L.] Emory Univ, Sch Med, Atlanta, GA 30322 USA. RP Quinn, CP (reprint author), Ctr Dis Control & Prevent, Div Bacterial Dis, Natl Ctr Immunizat & Resp Dis, 1600 Clifton Rd,MS-D11, Atlanta, GA 30333 USA. EM cquinn@cdc.gov RI Moon, James/B-6810-2011; OI Moon, James/0000-0002-9274-4554; Jacobson, Robert/0000-0002-6355-8752 FU Centers for Disease Control and Prevention; Atlanta Research and Education Foundation (AREF), Atlanta, Georgia FX The study was funded through the Centers for Disease Control and Prevention (CDC). Mr Soroka and Ms Fox were funded through the Atlanta Research and Education Foundation (AREF), Atlanta, Georgia. NR 40 TC 68 Z9 70 U1 0 U2 12 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 1 PY 2008 VL 300 IS 13 BP 1532 EP 1543 DI 10.1001/jama.300.13.1532 PG 12 WC Medicine, General & Internal SC General & Internal Medicine GA 354CY UT WOS:000259617700017 PM 18827210 ER PT J AU Hammers, DW Merritt, EK Matheny, W Adamo, ML Walters, TJ Estep, JS Farrar, RP AF Hammers, David W. Merritt, Edward K. Matheny, Wayne Adamo, Martin L. Walters, Thomas J. Estep, J. Scot Farrar, Roger P. TI Functional deficits and insulin-like growth factor-I gene expression following tourniquet-induced injury of skeletal muscle in young and old rats SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE aging; insulin-like growth factor-I; ischemia-reperfusion; muscle regeneration; sarcopenia ID FOXO TRANSCRIPTION FACTORS; STEM CELL ACTIVATION; IGF-I; OXIDATIVE STRESS; UBIQUITIN LIGASES; REGENERATION; HYPERTROPHY; ATROPHY; MICE; AGE AB This study investigated the effect of age on recovery of skeletal muscle from an ischemia-reperfusion (I/R)-induced injury. Young (6 mo old) and old (24-27 mo old) Sprague-Dawley rats underwent a 2-h bout of hindlimb ischemia induced by a pneumatic tourniquet (TK). The TK was released to allow reperfusion of the affected limb, and animals were divided into 7- and 14-day recovery groups. Maximum plantar flexor force production was assessed in both 7- and 14-day recovery groups of both ages, followed by histological evaluation. Subsequent analysis of IGF-I gene expression and intracellular signaling in 7-day recovery muscles was performed by RT-PCR and Western blotting, respectively. Old rats had significantly greater deficits in force production and exhibited more evidence of histological pathology than young at both 7 and 14 days postinjury. In addition, old rats demonstrated an attenuated upregulation of IGF-I mRNA and induction of proanabolic signaling compared with young in response to injury. We conclude that aged skeletal muscle exhibits more damage and/or defective regeneration following I/R and identify an age-associated decrease in local IGF-I responsiveness as a potential mechanism for this phenomenon. C1 [Hammers, David W.; Merritt, Edward K.; Farrar, Roger P.] Univ Texas Austin, Dept Kinesiol, Austin, TX 78712 USA. [Matheny, Wayne; Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA. [Matheny, Wayne; Adamo, Martin L.] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA. [Walters, Thomas J.; Estep, J. Scot] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Farrar, RP (reprint author), Univ Texas Austin, Dept Kinesiol, 1 Univ Stn D3700, Austin, TX 78712 USA. EM rfarrar@mail.utexas.edu FU U. S. Army Medical Research and Materiel Command [DAMD17-03-1-0735]; National Institute on Aging [R01-AG-026012] FX This work was funded in part by U. S. Army Medical Research and Materiel Command Grant DAMD17-03-1-0735 to R. P. Farrar and National Institute on Aging Grant R01-AG-026012 to M. L. Adamo. NR 72 TC 17 Z9 17 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 EI 1522-1601 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD OCT PY 2008 VL 105 IS 4 BP 1274 EP 1281 DI 10.1152/japplphysiol.90418.2008 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 357PA UT WOS:000259857400030 PM 18669936 ER PT J AU Schleicher, LS Miller, JW Watkins-Kenney, SC Carnes-McNaughton, LF Wilde-Ramsing, MU AF Schleicher, Lisa S. Miller, J. William Watkins-Kenney, Sarah C. Carnes-McNaughton, Linda F. Wilde-Ramsing, Mark U. TI Non-destructive chemical characterization of ceramic sherds from Shipwreck 31CR314 and Brunswick Town, North Carolina SO JOURNAL OF ARCHAEOLOGICAL SCIENCE LA English DT Article DE Shipwreck 31CR314; Queen Anne's Revenge; Blackbeard; ceramic oil jars; scanning electron microscopy; energy dispersive spectroscopy; underwater archaeology AB The purpose of this study was to chemically and texturally characterize ceramic oil jar sherds from North Carolina Shipwreck 31CR314 and to explore the utility of environmental scanning electron microscopy/X-ray energy dispersive spectrometry (SEM/EDS) for that purpose. The oil jar sherds, widely dispersed about Shipwreck 31CR314, are morphologically similar to each other, which suggests they could be from a single jar, but with so few joins this could not be concluded with certainty. Therefore, an aim of this study was to investigate whether chemical or textural characterization of the sherds might reveal unique attributes that could distinguish individual jars: results of characterization perhaps could give information on their Origin and possibly site formation processes, Such as whether environmental forces could have scattered sherds of a single jar during and after sinking of the ship. Previous Studies have indicated this shipwreck is likely the remnants of the Queen Anne's Revenge, flagship of the pirate Blackbeard. Sherds from this shipwreck were compared with similar oil jar sherds excavated from a land site, Brunswick Town, North Carolina, to explore the use of composition and texture as hallmarks. The chemical components of the artifacts were determined by SEM/EDS. This method of analysis is valuable for archaeological research because it is rapid and non-destructive to the ceramic artifacts. Both groups of lead-glazed coarse red earthenware sherds were texturally similar except for the glazed sides of all 31CR314 sherds that exhibited small tracks of unique crescent-shaped marks. These marks may be due to manufacturing effects and immersion in seawater, and the marks may serve as hallmarks for individual jars or potentially individual manufacturers. The sherds were generally Similar in composition, but the two groups exhibited distinct differences. Brunswick Town sherds consistently contained more phosphate On unglazed sides, an average 1.46 wt.% P2O5, and also contained trace elements not detected in the Shipwreck 31CR314 sherds. These distinct differences could be due to different manufacturing origins for Shipwreck 31CR314 and Brunswick Town ceramics but also could reflect their subjection to different environments during use and loss prior to archaeological recovery. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Schleicher, Lisa S.; Miller, J. William] Univ N Carolina, Dept Environm Studies, Asheville, NC 28804 USA. [Watkins-Kenney, Sarah C.] Queen Annes Revenge Shipwreck Project, N Carolina Dept Cultural Resources, Underwater Archaeol Branch, Greenville, NC 27834 USA. [Wilde-Ramsing, Mark U.] Queen Annes Revenge Shipwreck Project, N Carolina Dept Cultural Resources, Underwater Archaeol Branch, Kure Beach, NC 28449 USA. [Carnes-McNaughton, Linda F.] Cultural Resources Management Program, Ft Bragg, NC 28310 USA. RP Miller, JW (reprint author), Univ N Carolina, Dept Environm Studies, CPO 2330, Asheville, NC 28804 USA. EM jwmiller@unca.edu OI Schleicher, Lisa/0000-0001-6528-1753 FU Applied Geophysical Services; SEM; computer communications; National Science Foundation [0320792] FX We thank Bill Oliver, Office of State Archaeology Research Center(North Carolina), for historical archaeology information and access to the Brunswick Town ceramics and for editorial review. For financial support we thank the University of North Carolina at Asheville Undergraduate Research Program, Environmental Studies Department, and the New Horizons Fund for travel funds and additional program fees. The following paleontologists/ichnologists aided the effort to identify the crescent-shaped marks: Tony Martin of Ernory University, Richard Bromley of the Geological Institute (Copenhagen), Max Wisshak of the Institute of Paleontology (IPAL) at the University of Erlangen-Nuremberg, Ingrid Glaub of Frankfurt Bioerosion Group, Johann Wolfgang Goethe of the Universitat Institut fur Geowissenschaften, and members of the Houston Gem and Mineral Society. Thanks are due David Dickel, Florida Bureau of Archaeological Research, for consultation and expeditious loan of sherds. Thanks also to Lance Kearns, James Madison University, and all other reviewers whose insightful comments improved the manuscript. Special thanks to Kevin Sherwood, Applied Geophysical Services, for SEM and computer communications support. This project is based upon work supported by the National Science Foundation under Grant No. 0320792. NR 28 TC 8 Z9 9 U1 0 U2 14 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0305-4403 J9 J ARCHAEOL SCI JI J. Archaeol. Sci. PD OCT PY 2008 VL 35 IS 10 BP 2824 EP 2838 DI 10.1016/j.jas.2008.05.012 PG 15 WC Anthropology; Archaeology; Geosciences, Multidisciplinary SC Anthropology; Archaeology; Geology GA 349FF UT WOS:000259266000016 ER PT J AU Brainard, GC Sliney, D Hanifin, JP Glickman, G Byrne, B Greeson, JN Jasser, S Gerner, E Rollag, MD AF Brainard, George C. Sliney, David Hanifin, John P. Glickman, Gena Byrne, Brenda Greeson, Jeffrey N. Jasser, Samar Gerner, Edward Rollag, Mark D. TI Sensitivity of the human circadian system to short-wavelength (420-nm) light SO JOURNAL OF BIOLOGICAL RHYTHMS LA English DT Article DE melatonin; action spectrum; circadian; wavelength; light; pineal gland; neuroeodocrine; photoreception ID RETINAL GANGLION-CELLS; INDUCED MELATONIN SUPPRESSION; ACTION SPECTRUM; MELANOPSIN; RESPONSES; MICE; PHOTOSENSITIVITY; PHOTORECEPTOR; PHOTOPIGMENT; ROD AB The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment melanopsin. Nine action spectrum studies using rodents, monkeys, and humans for these responses indicate peak sensitivities in the blue region of the visible specturm ranging from 459 to 484 nm, with some disagreement in short-wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420-nm light for plasma melatonin suppression. Adult female (n = 14) and male (n = 12) subjects participated in 2 studies, each employing a within-subjects design. In a ftuence-response study, subjects (n = 8) were tested with 8 light irradiances at 420 nm ranging over a 4-log unit photon density range of 10(10) to 10(14) photons/cm(2)/sec and 1 dark control flight. In the other study subjects (n = 18) completed an experiment comparing melatonin suppression with equal photon doses (1.21. X 10(13) photons/cm(2)/sec) of 420 nm ans 460 nm monochromatic light and a dark exposure control night. The first study demonstrated a clear fluence-response relationship between 420-nm light and melatonin suppression (p < 0.001) with a half-saturation constant of 2.74 x 10(11) photons/cm(2)/sec. The second study showed that 460-nm light is significantly stronger than 420-nm light for suppressing melatonin (p < 0.04). Together, the results clarify the visible short-wavelenght sensitivity of the human melatonin suppression action spectrum. This basic physiological finding may be useful for optimizing lighting for therapeutic and other applications. C1 [Brainard, George C.; Hanifin, John P.; Glickman, Gena; Byrne, Brenda; Greeson, Jeffrey N.; Jasser, Samar; Gerner, Edward; Rollag, Mark D.] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA. [Sliney, David] USA, Ctr Hlth Promot & Prevent Med, Laser Opt Radiat Program, Aberdeen Proving Ground, MD USA. RP Brainard, GC (reprint author), Thomas Jefferson Univ, Dept Neurol, 1025 Walnut St,Suite 507, Philadelphia, PA 19107 USA. EM george.brainard@jefferson.edu RI Jelinek, Milan/C-8515-2011; Greeson, Jeffrey/A-9272-2009 OI Greeson, Jeffrey/0000-0003-4871-1197 FU NINDS NIH HHS [R01NS36590] NR 37 TC 76 Z9 77 U1 1 U2 24 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0748-7304 J9 J BIOL RHYTHM JI J. Biol. Rhythms PD OCT PY 2008 VL 23 IS 5 BP 379 EP 386 DI 10.1177/0748730408323089 PG 8 WC Biology; Physiology SC Life Sciences & Biomedicine - Other Topics; Physiology GA 354KX UT WOS:000259639600001 PM 18838601 ER PT J AU Das, S Pingle, MR Munoz-Jordan, J Rundell, MS Rondini, S Granger, K Chang, GJJ Kelly, E Spier, EG Larone, D Spitzer, E Barany, F Golightly, LM AF Das, S. Pingle, M. R. Munoz-Jordan, J. Rundell, M. S. Rondini, S. Granger, K. Chang, G. -J. J. Kelly, E. Spier, E. G. Larone, D. Spitzer, E. Barany, F. Golightly, L. M. TI Detection and serotyping of dengue virus in serum samples by multiplex reverse transcriptase PCR-ligase detection reaction assay SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID WEST-NILE-VIRUS; UNIVERSAL DNA MICROARRAY; MOUSE NEUROVIRULENCE; MUTATION DETECTION; HEMORRHAGIC-FEVER; RAPID DETECTION; CHAIN-REACTION; PUERTO-RICO; K-RAS; IDENTIFICATION AB The detection and successful typing of dengue virus (DENV) from patients with suspected dengue fever is important both for the diagnosis of the disease and for the implementation of epidemiologic control measures. A technique for the multiplex detection and typing of DENV serotypes 1 to 4 (DENV-1 to DENV-4) from clinical samples by PCR-ligase detection reaction (LDR) has been developed. A serotype-specific PCR amplifies the regions of genes C and E simultaneously. The two amplicons are targeted in a multiplex LDR, and the resultant fluorescently labeled ligation products are detected on a universal array. The assay was optimized using 38 DENV strains and was evaluated with 350 archived acute-phase serum samples. The sensitivity of the assay was 98.7%, and its specificity was 98.4%, relative to the results of real-time PCR. The detection threshold was 0.017 PFU for DENV-1, 0.004 PFU for DENV-2, 0.8 PFU for DENV-3, and 0.7 PFU for DENV-4. The assay is specific; it does not cross-react with the other flaviviruses tested (West Nile virus, St. Louis encephalitis virus, Japanese encephalitis virus, Kunjin virus, Murray Valley virus, Powassan virus, and yellow fever virus). All but 1 of 26 genotypic variants of DENV serotypes in a global DENV panel from different geographic regions were successfully identified. The PCR-LDR assay is a rapid, sensitive, specific, and high-throughput technique for the simultaneous detection of all four serotypes of DENV. C1 [Das, S.; Rondini, S.; Golightly, L. M.] Cornell Univ, Weill Med Coll, Div Int Med & Infect Dis, Dept Med, New York, NY 10021 USA. [Pingle, M. R.; Rundell, M. S.; Granger, K.; Barany, F.] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA. [Larone, D.] Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA. [Spitzer, E.] SUNY Stony Brook, Med Ctr, Dept Pathol, Stony Brook, NY 11794 USA. [Munoz-Jordan, J.] Ctr Dis Control & Prevent, San Juan, PR USA. [Chang, G. -J. J.] Ctr Dis Control & Prevent, Ft Collins, CO USA. [Kelly, E.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Spier, E. G.] Appl Biosyst Inc, Foster City, CA USA. RP Golightly, LM (reprint author), Cornell Univ, Weill Med Coll, Div Int Med & Infect Dis, Dept Med, 1300 York Ave,Room A 421, New York, NY 10021 USA. EM lgolight@med.cornell.edu RI Rondini, Simona/N-1780-2013 OI Rondini, Simona/0000-0002-7993-9656 FU National Institute of Allergy and Infectious Diseases [UC1-AI062579] FX This work was supported by Public Health Service grant UC1-AI062579 from the National Institute of Allergy and Infectious Diseases. NR 45 TC 32 Z9 38 U1 0 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD OCT PY 2008 VL 46 IS 10 BP 3276 EP 3284 DI 10.1128/JCM.00163-08 PG 9 WC Microbiology SC Microbiology GA 356DM UT WOS:000259758900014 PM 18685000 ER PT J AU Kuz'min, VE Muratov, EN Artemenko, AG Gorb, L Qasim, M Leszczynski, J AF Kuz'min, Victor E. Muratov, Eugene N. Artemenko, Anatoly G. Gorb, Leonid Qasim, Mohammad Leszczynski, Jerzy TI The effects of characteristics of substituents on toxicity of the nitroaromatics: HiT QSAR study SO JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN LA English DT Article DE applicability domain; HiT QSAR; nitroaromatic compounds; SiRMS; targeted design; toxicity in vivo; virtual screening ID SIMPLEX REPRESENTATION; MOLECULAR-STRUCTURE; VARIABLE SELECTION; QUANTITATIVE STRUCTURE; PREDICTION; MODELS; PLS; IDENTIFICATION; MUTAGENICITY; TOXICOPHORES AB The present study applies the Hierarchical Technology for Quantitative Structure-Activity Relationships (HiT QSAR) for (i) evaluation of the influence of the characteristics of 28 nitroaromatic compounds (some of which belong to a widely known class of explosives) as to their toxicity; (ii) prediction of toxicity for new nitroaromatic derivatives; (iii) analysis of the effects of substituents in nitroaromatic compounds on their toxicity in vivo. The 50% lethal dose concentration for rats (LD(50)) was used to develop the QSAR models based on simplex representation of molecular structure. The preliminary 1D QSAR results show that even the information on the composition of molecules reveals the main tendencies of changes in toxicity. The statistic characteristics for partial least squares 2D QSAR models are quite satisfactory (R(2) = 0.96-0.98; Q(2) = 0.91-0.93; R(test)(2) = 0.89-0.92), which allows us to carry out the prediction of activity for 41 novel compounds designed by the application of new combinations of substituents represented in the training set. The comprehensive analysis of toxicity changes as a function of substituent position and nature was carried out. Molecular fragments that promote and interfere with toxicity were defined on the basis of the obtained models. It was shown that the mutual influence of substituents in the benzene ring plays a crucial role regarding toxicity. The influence of different substituents on toxicity can be mediated via different C-H fragments of the aromatic ring. C1 [Kuz'min, Victor E.; Muratov, Eugene N.; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Kuz'min, Victor E.; Muratov, Eugene N.; Artemenko, Anatoly G.] Natl Acad Sci Ukraine, AV Bogatsky Phys Chem Inst, Odessa, Ukraine. [Gorb, Leonid] USA, ERDC SpecPro, Vicksburg, MS 39180 USA. [Qasim, Mohammad] USA, ERDC, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Computat Ctr Mol Struct & Interact, 1400 JR Lynch St, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Muratov, Eugene/C-4454-2014 OI Muratov, Eugene/0000-0003-4616-7036 FU US Army Engineer Research and Development Center [W912Z-04-P-139]; US Army Engineer Research and Development Center CMCM [2T346GM007672-25A1] FX US Army Environmental Quality Technology Program (grant W912Z-04-P-139) administrated by the US Army Engineer Research and Development Center; US Army Engineer Research and Development Center CMCM program (grant 2T346GM007672-25A1). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors. NR 38 TC 21 Z9 21 U1 0 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-654X J9 J COMPUT AID MOL DES JI J. Comput.-Aided Mol. Des. PD OCT PY 2008 VL 22 IS 10 BP 747 EP 759 DI 10.1007/s10822-008-9211-x PG 13 WC Biochemistry & Molecular Biology; Biophysics; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Computer Science GA 348DD UT WOS:000259190300005 PM 18385948 ER PT J AU Goodson, LP AF Goodson, Larry P. TI THE 2008 ELECTIONS SO JOURNAL OF DEMOCRACY LA English DT Article C1 USA, War Coll, Carlisle, PA USA. RP Goodson, LP (reprint author), USA, War Coll, Carlisle, PA USA. NR 5 TC 2 Z9 2 U1 0 U2 1 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 1045-5736 J9 J DEMOCR JI J. Democr. PD OCT PY 2008 VL 19 IS 4 BP 5 EP 15 PG 11 WC Political Science SC Government & Law GA 362IE UT WOS:000260190600001 ER PT J AU Liu, JC Melloh, RA Woodcock, CE Davis, RE Painter, TH Mckenzie, C AF Liu, Jicheng Melloh, Rae A. Woodcock, Curtis E. Davis, Robert E. Painter, Thomas H. Mckenzie, Ceretha TI Modeling the View Angle Dependence of Gap Fractions in Forest Canopies: Implications for Mapping Fractional Snow Cover Using Optical Remote Sensing SO JOURNAL OF HYDROMETEOROLOGY LA English DT Article ID LANDSAT THEMATIC MAPPER; BOREAL CONIFER FORESTS; ABLATION; RADIATION; EXTENT; STAND; AREA AB Forest canopies influence the proportion of the land surface that is visible from above, or the viewable gap fraction (VGF). The VGF limits the amount of information available in satellite data about the land surface, such as snow cover in forests. Efforts to recover fractional snow cover from the spectral mixture analysis model Moderate Resolution Imaging Spectroradiometer (MODIS) snow-covered area and grain size (MODSCAG) indicate the importance of view angle effects in forested landscapes. The VGF can be estimated using both hemispherical photos and forest canopy models. For a set of stands in the Cold Land Field Processes Experiment (CLPX) sites in the Fraser Experimental Forest in Colorado, the convergence of both measurements and models of the VGF as a function of view angle supports the idea that VGF can be characterized as a function of forest properties. A simple geometric optical (GO) model that includes only between-crown gaps can capture the basic shape of the VGF as a function of view zenith angle. However, the GO model tends to underestimate the VGF compared with estimates derived from hemispherical photos, particularly at high view angles. The use of a more complicated geometric optical-radiative transfer (GORT) model generally improves estimates of the VGF by taking into account within-crown gaps. Small footprint airborne lidar data are useful for mapping forest cover and height, which makes the parameterization of the GORT model possible over a landscape. Better knowledge of the angular distribution of gaps in forest canopies holds promise for improving remote sensing of snow cover fraction. C1 [Liu, Jicheng; Woodcock, Curtis E.] Boston Univ, Dept Geog & Environm, Boston, MA 02215 USA. [Melloh, Rae A.; Davis, Robert E.; Mckenzie, Ceretha] USA, Cold Reg Res & Engn Lab, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. [Painter, Thomas H.] Univ Utah, Dept Geog, Salt Lake City, UT USA. RP Liu, JC (reprint author), Boston Univ, Dept Geog & Environm, 675 Commonwealth Ave, Boston, MA 02215 USA. EM jcliu@bu.edu RI Liu, Jicheng/B-4575-2009; Painter, Thomas/B-7806-2016 FU U. S. Army.; NASA Earth Science Enterprise; Terrestrial Hydrology Program; Earth Observing System Program; Airborne Science Program; National Oceanic and Atmospheric Administration Office of Global Programs; U. S. Army Corps of Engineers Civil Works Remote Sensing Research Program; U. S. Army Basic Research Program; National Space Development Agency of Japan (NASDA); Japan Science and Technology Corporation; National Assembly for Wales; Strategic Research Investment Fund; Cardiff; South Glamorgan; United Kingdom; U. S. Army Contract [DACA42-03-C-0033] FX This research was supported by the U. S. Army. The efforts of the more than 200 people who participated in the planning and execution of CLPX 2002-2003 are very much appreciated. The CLPX was funded through the cooperation of many agencies and organizations including the NASA Earth Science Enterprise, Terrestrial Hydrology Program, Earth Observing System Program, and Airborne Science Program; the National Oceanic and Atmospheric Administration Office of Global Programs; the U. S. Army Corps of Engineers Civil Works Remote Sensing Research Program; the U. S. Army Basic Research Program; the National Space Development Agency of Japan (NASDA); the Japan Science and Technology Corporation; and the National Assembly for Wales, Strategic Research Investment Fund, Cardiff, South Glamorgan, United Kingdom. A portion of this work was conducted at the Jet Propulsion Laboratory at the California Institute of Technology, under contract to the National Aeronautics and Space Administration NASA. We would also like to thank Thomas Berry of ERDC/Vicksburg for collecting GPS locations of our forest stands and Stephen Miller of Johnson, Kunkel and Associates, Inc. for information on the specifications of the lidar. This work was supported by U. S. Army Contract DACA42-03-C-0033. NR 27 TC 16 Z9 16 U1 1 U2 15 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 1525-755X J9 J HYDROMETEOROL JI J. Hydrometeorol. PD OCT PY 2008 VL 9 IS 5 BP 1005 EP 1019 DI 10.1175/2008JHM866.1 PG 15 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 359UB UT WOS:000260012500012 ER PT J AU Grujicic, M Bell, WC He, T Cheeseman, BA AF Grujicic, M. Bell, W. C. He, T. Cheeseman, B. A. TI Development and verification of a meso-scale based dynamic material model for plain-woven single-ply ballistic fabric SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID FINITE-DEFORMATION THEORY; WEAVE FABRICS; IMPACT; FRICTION; ARMOR; SIMULATION; BEHAVIOR AB A meso-scale unit-cell based continuum material constitutive model has been developed for plain-woven single-ply ballistic fabric materials. This model, due to its computational efficiency, is suitable for use in computational analyses of the ballistic-protection performance of multi-layer body-armor vests. The model utilizes the continuum-level in-plane and out-of-plane deformation-state of the material, an energy minimization procedure and a simple account of yarn slip to update the structure/architecture of the fabric unit cell. Forces and moments developed within the structural components of the unit cell are then used to compute the continuum-level stress state at the material points associated with the unit cell in question. The model is implemented in a user-material subroutine suitable for use within commercial finite-element programs. To validate the model, a series of transient non-linear dynamic analyses of the impact of a square-shaped fabric patch with a spherical projectile is carried out and the computed results compared with their counterparts obtained using a more traditional finite-element approach within which yarns and yarn weaving are modeled explicitly. The results obtained show that the material model provides a reasonably good description for the fabric deformation and fracture behavior under a variety of boundary conditions applied to fabric edges and under varying fictional conditions present at the yarn/yarn and projectile/fabric interfaces. In addition, the overall ballistic energy absorption capacity of the fabric as well as its yarn-strain energy, yarn-kinetic energy, and frictional sliding contributions are predicted with reasonable accuracy by the proposed material model for fabric. C1 [Grujicic, M.; Bell, W. C.; He, T.] Clemson Univ, CU ICAR, Dept Mech Engn, Clemson, SC 29634 USA. [Cheeseman, B. A.] USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, CU ICAR, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu FU U.S. Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX The material presented in this article is based on work supported by the U.S. Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042. The authors are indebted to Dr. Fred Stanton for the support and a continuing interest in the present work. NR 28 TC 16 Z9 16 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD OCT PY 2008 VL 43 IS 18 BP 6301 EP 6323 DI 10.1007/s10853-008-2893-6 PG 23 WC Materials Science, Multidisciplinary SC Materials Science GA 358OX UT WOS:000259928500038 ER PT J AU Anderson, J Reynolds, C Ringelberg, D Edwards, J Foley, K AF Anderson, J. Reynolds, C. Ringelberg, D. Edwards, J. Foley, K. TI Differentiation of live-viable versus dead bacterial endospores by calibrated hyperspectral reflectance microscopy SO JOURNAL OF MICROSCOPY LA English DT Article DE bacteria; endospores; hyperspectral; microscopy; spectral reflectance; viability AB This paper describes the use of hyperspectral imaging microscopy (HIM) for the characterization and differentiation of live viable versus dead/non-viable bacterial endospores for two species of Bacillus. To accomplish this, endospore-forming Bacillus were cultured and differentiated into endospores. Non-viable endospores were produced using sporicidal methods representing standard decontamination procedures incorporating chlorine and peroxide. Finally, endospore samples were lyophilized to prepare them for spectral analysis. Prior to HIM, baseline spectral reflectance characterizing the endospores was measured using an ASD (400-900 nm) reflectance spectrometer. These data were used to calibrate the resulting spectral image data. HIM data comprising 32 images ranging from 400 to 720 nm (visible to near infrared) were recorded using a C-mounted VariSpec hyperspectral camera attached to an epifluorescent microscope. The images produced by the system record the reflectance and absorption features of endospores based on the structure of the outer coat. Analysis of the HIM data was performed using accepted image and spectral processing routines. Where peroxide was the sporicide, changes in the outer endospore coat contributed to structurally significant visible and near infrared signature differences between live-viable versus dead, non-viable endospores. A statistical test for divergence, a method for scoring spectral structural diversity, also showed the difference between viable and non-viable peroxide killed endospores to be statistically significant. These findings may lead to an improved optical procedure to rapidly identify viable and non-viable endospores in situations of decontamination. C1 [Anderson, J.; Edwards, J.] USA, Engineer Res & Dev Ctr, Alexandria, VA USA. [Reynolds, C.; Ringelberg, D.; Foley, K.] USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. RP Anderson, J (reprint author), USA, Engineer Res & Dev Ctr, Alexandria, VA USA. EM John.Anderson@usace.army.mil FU Signature Support Program (SSP); Next Generation Integrated Signatures; United States Army ERDC FX This work was supported by the Signature Support Program (SSP) under a Next Generation Integrated Signatures grant and the United States Army ERDC. NR 15 TC 9 Z9 9 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0022-2720 J9 J MICROSC-OXFORD JI J. Microsc.. PD OCT PY 2008 VL 232 IS 1 BP 130 EP 136 DI 10.1111/j.1365-2818.2008.02074.x PG 7 WC Microscopy SC Microscopy GA 352VK UT WOS:000259525300015 PM 19017210 ER PT J AU Birtle, AJ AF Birtle, Andrew J. TI PROVN Westmoreland, and the historians: A reappraisal SO JOURNAL OF MILITARY HISTORY LA English DT Article AB Historians have often used a 1966 Army report nicknamed PROVN either to cast aspersions on the commander of U.S. forces in Vietnam between 1964 and 1968, General William C. Westmoreland, or to praise his successor, General Creighton Abrams. This interpretation is simplistic and inaccurate. Although the report criticized aspects of the war under Westmoreland, its target was really the U.S. and Vietnamese governments. Moreover, PROVN's conclusions were less radical and its remedies less novel than observers have tended to admit. A fresh look at PROVN reveals significant continuities in thought between Westmoreland, the report, and Abrams. C1 USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Birtle, AJ (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 38 TC 5 Z9 5 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2008 VL 72 IS 4 BP 1213 EP 1247 PG 35 WC History SC History GA 354RC UT WOS:000259655700008 ER PT J AU Bielakowski, AM AF Bielakowski, Alexander M. TI Cavalry from hoof to track SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Bielakowski, Alexander M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Bielakowski, AM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2008 VL 72 IS 4 BP 1272 EP 1273 PG 2 WC History SC History GA 354RC UT WOS:000259655700013 ER PT J AU Kautt, W AF Kautt, William TI Ethics, nationalism, and just war: Medieval and contemporary perspectives SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Kautt, William] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kautt, W (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2008 VL 72 IS 4 BP 1276 EP 1277 PG 2 WC History SC History GA 354RC UT WOS:000259655700017 ER PT J AU House, JM AF House, Jonathan M. TI Chasing ghosts: Unconventional warfare in American history SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [House, Jonathan M.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP House, JM (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2008 VL 72 IS 4 BP 1284 EP 1285 PG 2 WC History SC History GA 354RC UT WOS:000259655700024 ER PT J AU Kuehn, JT AF Kuehn, John T. TI The battle of Borodino: Napoleon against Kutuzov SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Kuehn, John T.] USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Kuehn, JT (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 1 U2 2 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2008 VL 72 IS 4 BP 1295 EP 1296 PG 2 WC History SC History GA 354RC UT WOS:000259655700033 ER PT J AU Grau, LW AF Grau, Lester W. TI Architect of global jihad: The life of Al-Qaida strategist Abu Musab al-Suri SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 [Grau, Lester W.] Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Grau, LW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 2008 VL 72 IS 4 BP 1338 EP 1338 PG 1 WC History SC History GA 354RC UT WOS:000259655700072 ER PT J AU Morrill, JA Byrd, EFC AF Morrill, Jason A. Byrd, Edward F. C. TI Development of quantitative structure-property relationships for predictive modeling and design of energetic materials SO JOURNAL OF MOLECULAR GRAPHICS & MODELLING LA English DT Article DE QSPR; QSAR; AM1 semiempirical; Impact sensitivity; Energetic material ID IMPACT SENSITIVITY; NEURAL-NETWORKS; MOLECULES; EXPLOSIVES; BOND; DETONATION; OUTLIERS; QSAR AB A quantitative structure-property relationship (QSPR) based on the AM1 semiempirical quantum mechanical method was derived using the program, CODESSA, to describe published drop height impact sensitivities for 227 nitroorganic compounds. An eight-descriptor correlation equation having R-2 = 0.8141 was obtained through a robust least median squares regression. The resulting model is the most comprehensive and systematic quantum mechanically derived QSPR for energetic materials of those that have been published. The predictive capability of the model is also presented and discussed. (C) 2008 Elsevier Inc. All rights reserved. C1 [Morrill, Jason A.] William Jewell Coll, Dept Chem, Liberty, MO 64068 USA. [Byrd, Edward F. C.] USA, Res Labs, AMSRD ARL WM BD, Aberdeen Proving Ground, MD 21005 USA. RP Morrill, JA (reprint author), William Jewell Coll, Dept Chem, 500 Coll Hill, Liberty, MO 64068 USA. EM morrillj@william.jewell.edu FU Army Research Laboratory FX This work was supported by the Army Research Laboratory under the auspices of the U.S. Army Research Office Scientific Services Program administered by Battelle. J.M. would like to thank Betsy Rice for many helpful discussions related to this work. NR 27 TC 24 Z9 24 U1 1 U2 19 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1093-3263 J9 J MOL GRAPH MODEL JI J. Mol. Graph. PD OCT PY 2008 VL 27 IS 3 BP 349 EP 355 DI 10.1016/j.jmgm.2008.06.003 PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Computer Science, Interdisciplinary Applications; Crystallography; Mathematical & Computational Biology SC Biochemistry & Molecular Biology; Computer Science; Crystallography; Mathematical & Computational Biology GA 374AA UT WOS:000261013400013 PM 18653366 ER PT J AU Taylor, JT Davis, E Dabisch, P Horsmon, M Li, M Mioduszewski, R AF Taylor, James T. Davis, Emily Dabisch, Paul Horsmon, Mike Li, Ming Mioduszewski, Robert TI Alterations in Autonomic Function in the Guinea Pig Eye Following Exposure to Dichlorvos Vapor SO JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS LA English DT Article ID SARIN VAPOR; RETINAL DEGENERATION; PUPILLARY FUNCTION; METRIFONATE; RATS; ACETYLCHOLINE; DYSFUNCTION; TOLERANCE; FENTHION; RELEASE AB The present study investigated the effect of the organophosphate, dichlorvos (DDVP), on ocular function and cholinesterase activity in guinea pigs, using a single-animal-head-only vapor exposure system. All animals exhibited signs of mild organophosphate poisoning (e.g., salivation, chewing, lacrimation, urination, defecation, and rhinorhea) after the 20-min exposure, regardless of the DDVP exposure concentration (e.g., 35 mg/m(3), 55 mg/m3, and 75 mg/m3). Pupil constriction or miosis was the most pronounced effect seen after vapor exposure. The postexposure pupil size for the 35 mg/m(3) group was 45.8 +/- 3.68% of the preexposure baseline measurement. Postexposure pupil size in the 55- (38 +/- 1.36%) and 75 mg/m(3) (38.1 +/- 1.72%) groups was significantly less than both the preexposure baseline level and the 35 mg/m3 group. All groups exhibited enhanced an pupillary response to light after DDVP exposure. The enhanced light response remained even after recovery from miosis (similar to 1 h after exposure). Measurement of cholinesterase activity revealed that even though pupil size had recovered, acetyl- and butyrylcholinesterse remained significantly inhibited in the blood. C1 [Taylor, James T.] US Army Edgewood Chem Biol Ctr, ATTN AMSRD ECB RT TT, Aberdeen Proving Ground, MD 21010 USA. [Taylor, James T.; Davis, Emily; Dabisch, Paul; Horsmon, Mike; Mioduszewski, Robert] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Taylor, James T.] Natl Acad Sci, Natl Res Council, Washington, DC 20418 USA. [Li, Ming] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA. RP Taylor, JT (reprint author), US Army Edgewood Chem Biol Ctr, ATTN AMSRD ECB RT TT, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM james.tracy.taylor@us.army.mil NR 22 TC 2 Z9 2 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1080-7683 J9 J OCUL PHARMACOL TH JI J. Ocular Pharmacol. Ther. PD OCT PY 2008 VL 24 IS 5 BP 473 EP 479 DI 10.1089/jop.2008.0020 PG 7 WC Ophthalmology; Pharmacology & Pharmacy SC Ophthalmology; Pharmacology & Pharmacy GA 360PB UT WOS:000260068500006 PM 18788997 ER PT J AU Teyhen, DS Rieger, JL Westrick, RB Miller, AC Molloy, JM Childs, JD AF Teyhen, Deydre S. Rieger, Jennifer L. Westrick, Richard B. Miller, Amy C. Molloy, Joseph M. Childs, John D. TI Changes in Deep Abdominal Muscle Thickness During Common Trunk-Strengthening Exercises Using Ultrasound Imaging SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE internal oblique; low Lack pain; lumbar stabilization; sonography; therapeutic exercise; transversus abdominis ID LOW-BACK-PAIN; LUMBAR MULTIFIDUS MUSCLE; TRANSVERSUS-ABDOMINIS; LIMB MOVEMENT; DRAWING-IN; CONTRACTION; VARIETY; ULTRASONOGRAPHY; RECRUITMENT; LOADS AB STUDY DESIGN: Cross-sectional study design. OBJECTIVES: To characterize changes in muscle thickness in the transversus abdominis (TrA) and internal oblique (10) muscles during common trunk-strengthening exercises, and to determine whether these changes differ based on age. BACKGROUND: Although trunk-strengthening exercises have been found to be useful in treating those with low back pain (LBP), our understanding of the relative responses of the TrA and 10 muscles during different exercises is limited. METHODS AND MEASURES: Six commonly prescribed trunk-strengthening exercises were performed by 120 subjects (40 subjects per age group: 18-30, 31-40, and 41-50 years). Ultrasound imaging was used to measure the thickness of the TrA and 10 during the resting and contracted state of each exercise. The average thickness of the muscles while in the contracted position was divided by the thickness values in the resting position for each exercise, based on 2 performances of each exercise. Two 3-by-6 repeated-measures analyses of variance were used to determine significant changes in muscle thickness of the TrA and 10, based on age group and exercise performed. RESULTS: For both muscles, the trunk exercise-by-age interaction effect (TrA, P = .358; IO, P = .217) and the main effect for age (TrA, P = .615; 10, P = .219) were not significant. A significant main effect for trunk exercise for both muscles (P < .001) was found. The horizontal side-support (mean SD contracted-rest thickness ratio: TrA, 1.95 +/- 0.69; 10, 1.88 +/- 0.52) and the abdominal crunch (mean +/- SID contracted-rest thickness ratio: TrA, 1.74 +/- 0.48; 10, 1.63 +/- 0.41) exercises resulted in the greatest change in muscle thickness for both muscles. The abdominal drawing-in maneuver (mean +/- SID contracted-rest thickness ratio: TrA, 1.73 +/- 0.36; 10, 1.14 +/- 0.33) and quadruped opposite upper and lower extremity lift (mean +/- SID contracted-rest thickness ratio: TrA, 1.59 +/- 0.49; 10, 1.25 +/- 0.36) exercises resulted in changes in TrA muscle thickness with minimal changes in 10 muscle thickness. CONCLUSION: Changes in TrA and 10 muscle thickness differed across 6 commonly prescribed trunk-strengthening exercises among healthy subjects without LBF. These differences did not vary by age. This information may be useful for informing exercise prescription. LEVEL OF EVIDENCE: Therapy, level 5. J Orthop Sports Phys Ther 2008;38(10):596-605. doi:10.2519/jospt.2008.2897 C1 [Teyhen, Deydre S.; Molloy, Joseph M.; Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. [Teyhen, Deydre S.] Walter Reed Army Med Ctr, Spine Res Ctr, Washington, DC 20307 USA. [Rieger, Jennifer L.] Carl R Darnall Army Med Ctr, Ft Hood, TX USA. [Westrick, Richard B.] Special Forces Grp 10, Ft Carson, CO USA. [Miller, Amy C.] 426 Base Support Battal, Brigade Combat Team 1, Airborne Div 101st, Ft Campbell, KY USA. RP Teyhen, DS (reprint author), 3151 Scott Rd,Room 1303,ATTN MCCS HMT MAJ Teyhen, Ft Sam Houston, TX 78234 USA. EM Deydre.teyhen@us.army.mil NR 41 TC 47 Z9 49 U1 1 U2 15 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD OCT PY 2008 VL 38 IS 10 BP 596 EP 605 DI 10.2519/jospt.2008.2897 PG 10 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 359YK UT WOS:000260024000003 PM 18827329 ER PT J AU Kuehn, D May, J Bauer, AJ AF Kuehn, Devon May, Joseph Bauer, Andrew J. TI Phospho-soda-induced symptomatic hypocalcemia in a patient with cystic fibrosis and vitamin D malabsorption SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Article ID ORAL SODIUM-PHOSPHATE; BOWEL PREPARATION; SEVERE HYPERPHOSPHATEMIA; CROHNS-DISEASE; SERUM ELECTROLYTES; COLONOSCOPY; INFANT; TETANY; ENEMA C1 [Bauer, Andrew J.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Kuehn, Devon; May, Joseph] Natl Naval Med Ctr, Natl Capital Consortium Pediat Residency Program, Bethesda, MD USA. [Kuehn, Devon; May, Joseph; Bauer, Andrew J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Bauer, AJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM abauer@usuhs.mil NR 22 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-2116 J9 J PEDIATR GASTR NUTR JI J. Pediatr. Gastroenterol. Nutr. PD OCT PY 2008 VL 47 IS 4 BP 514 EP 516 DI 10.1097/MPG.0b013e31811f3561 PG 3 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA 353SE UT WOS:000259587700017 PM 18852647 ER PT J AU Raney, EM Freccero, DM Dolan, LA Lighter, DE Fillman, RR Chambers, HG AF Raney, Ellen M. Freccero, David M. Dolan, Lori A. Lighter, Donald E. Fillman, Ramona R. Chambers, Henry G. TI Evidence-Based Analysis of Removal of Orthopaedic Implants in the Pediatric Population SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE implant removal; pediatric; orthopaedic ID CAPITAL FEMORAL EPIPHYSIS; INTERNAL-FIXATION; SCREW REMOVAL; METAL REMOVAL; PIN REMOVAL; CHILDREN; COMPLICATIONS; FOREARM; PLATES; CORROSION AB Background: Requested project of the Pediatric Orthopaedic Society of North America Evidenced-Based Medicine Committee. Methods: The English literature was systematically reviewed for scientific evidence supporting or disputing the common practice of elective removal of implants in children. Results: Several case series reported implant removal, but none contained a control group with retained implants. No articles reported long-term outcomes of retained implants in large numbers. Several small series describe complications associated with retained implants without evidence of causation. The existing literature was not amenable to a meta-analysis. By compiling data from the literature, it is possible to calculate a complication rate of 10% for implant removal surgery. The complication rate for removal of implants placed for slipped capital femoral epiphysis is 34%. Articles regarding postmarket implant surveillance and basic science were also reviewed. Conclusions: There is no evidence in the current literature to support or refute the practice of routine implant removal in children. C1 [Raney, Ellen M.; Fillman, Ramona R.] Shriners Hosp Children, Honolulu, HI USA. [Freccero, David M.] Tripler Army Med Ctr, Orthopaed Surg Serv, Honolulu, HI 96859 USA. [Dolan, Lori A.] Univ Iowa Hosp, Dept Orthopaed & Rehabil, Iowa City, IA USA. [Lighter, Donald E.] Shriners Hosp Children, Tampa, FL USA. RP Raney, EM (reprint author), 1310 Punahou St, Honolulu, HI 96826 USA. EM eraney@shrinenet.org OI Dolan, Lori/0000-0003-2455-2187 NR 30 TC 22 Z9 22 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD OCT-NOV PY 2008 VL 28 IS 7 BP 701 EP 704 PG 4 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA 392ET UT WOS:000262286400001 PM 18812893 ER PT J AU Killgore, WDS Cotting, DI Thomas, JL Cox, AL McGurk, D Vo, AH Castro, CA Hoge, CW AF Killgore, William D. S. Cotting, Dave I. Thomas, Jeffrey L. Cox, Anthony L. McGurk, Dennis Vo, Alexander H. Castro, Carl A. Hoge, Charles W. TI Post-combat invincibility: Violent combat experiences are associated with increased risk-taking propensity following deployment SO JOURNAL OF PSYCHIATRIC RESEARCH LA English DT Article DE risk taking; combat mental health; EVAR; Iraq; public health ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH PROBLEMS; SENSATION-SEEKING; WAR VETERANS; PSYCHIATRIC-DISORDERS; POPULATION; IRAQ; AFGHANISTAN; BEHAVIORS; CARE AB Combat exposure is associated with increased rates of mental health problems such as post-traumatic stress disorder, depression, and anxiety when Soldiers return home. Another important health consequence of combat exposure involves the potential for increased risk-taking propensity and unsafe behavior among returning service members. Survey responses regarding 37 different combat experiences were collected from 1252 US Army Soldiers immediately upon return home from combat deployment during Operation Iraqi Freedom. A second survey that included the Evaluation of Risks Scale (EVAR) and questions about recent risky behavior was administered to these same Soldiers 3 months after the initial post-deployment Survey. Combat experiences were reduced to seven factors using principal components analysis and used to predict post-deployment risk-propensity scores. Although effect sizes were small, specific combat experiences, including greater exposure to violent combat, killing another person, and contact with high levels of human trauma, were predictive of greater risk-taking propensity after homecoming. Greater exposure to these combat experiences was also predictive of actual risk-related behaviors in the preceding month, including more frequent and greater quantities of alcohol use and increased verbal and physical aggression toward others. Exposure to violent combat, human trauma, and having direct responsibility for taking the life of another person may alter an individual's perceived threshold of invincibility and slightly increase the propensity to engage in risky behavior upon returning home after wartime deployment. Findings highlight the importance of education and counseling for returning service members to mitigate the public health consequences of elevated risk-propensity associated with combat exposure. Published by Elsevier Ltd. C1 [Killgore, William D. S.; Thomas, Jeffrey L.; Cox, Anthony L.; McGurk, Dennis; Castro, Carl A.; Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Cotting, Dave I.] Virginia Mil Inst, Lexington, VA 24450 USA. [Vo, Alexander H.] Univ Texas Med Branch, Galveston, TX USA. RP Killgore, WDS (reprint author), Harvard Univ, McLean Hosp, Sch Med, Cognit Neuroimaging Lab, 115 Mill St, Belmont, MA 02478 USA. EM Kiligore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 35 TC 102 Z9 103 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-3956 J9 J PSYCHIATR RES JI J. Psychiatr. Res. PD OCT PY 2008 VL 42 IS 13 BP 1112 EP 1121 DI 10.1016/j.jpsychires.2008.01.001 PG 10 WC Psychiatry SC Psychiatry GA 351JL UT WOS:000259420500008 PM 18291419 ER PT J AU Summers, V Grant, KW Walden, BE Cord, MT Surr, RK Elhilali, M AF Summers, Van Grant, Ken W. Walden, Brian E. Cord, Mary T. Surr, Rauna K. Elhilali, Mounya TI Evaluation of a "Direct-Comparison" Approach to Automatic Switching in Omnidirectional/Directional Hearing Aids SO JOURNAL OF THE AMERICAN ACADEMY OF AUDIOLOGY LA English DT Article DE Automatic switching; directional processing; hearing aids; microphone preferences ID SPEECH-INTELLIGIBILITY; NOISE; MICROPHONE; ACCLIMATIZATION; RECOGNITION AB Background: Hearing aids today often provide both directional (DIR) and omnidirectional (OMNI) processing options with the currently active mode selected automatically by the device. The most common approach to automatic switching involves "acoustic scene analysis" where estimates of various acoustic properties of the listening environment (e.g., signal-to-noise ratio [SNR], overall sound level) are used as a basis for switching decisions. Purpose: The current study was carried out to evaluate an alternative, "direct-comparison" approach to automatic switching that does not involve assumptions about how the listening environment may relate to microphone preferences. Predictions of microphone preference were based on whether DIR-or OMNI-processing of a given listening environment produced a closer match to a reference template representing the spectral and temporal modulations present in clean speech. Research Design: A descriptive and correlational study. Predictions of OMNI/DIR preferences were determined based on degree of similarity between spectral and temporal modulations contained in a reference, clean-speech template, and in OMNI- and DIR-processed recordings of various listening environments. These predictions were compared with actual preference judgments (both real-world judgments and laboratory responses to the recordings). Data Collection and Analysis: Predictions of microphone preference were based on whether DIR-or OMNI-processing of a given listening environment produced a closer match to a reference template representing clean speech. The template is the output of an auditory processing model that characterizes the spectral and temporal modulations associated with a given input signal (clean speech in this case). A modified version of the spectro-temporal modulation index (mSTMI) was used to compare the template to both DIR- and OMNI-processed versions of a given listening environment, as processed through the same auditory model. These analyses were carried out on recordings (originally collected by Walden et al, 2007) of OMNI- and DIR-processed speech produced in a range of everyday listening situations. Walden et al reported OMNI/DIR preference judgments made by raters at the same time the field recordings were made and judgments based on laboratory presentations of these recordings to hearing-impaired and normal-hearing listeners. Preference predictions based on the mSTMI analyses were compared with both sets of preference judgments. Results: The mSTMI analyses showed better than 92% accuracy in predicting the field preferences and 82-85% accuracy in predicting the laboratory preference judgments. OMNI processing tended to be favored over DIR processing in cases where the analysis indicated fairly similar mSTMI scores across the two processing modes. This is consistent with the common clinical assignment of OMNI mode as the default setting, most likely to be preferred in cases where neither mode produces a substantial improvement in SNR. Listeners experienced with switchable OMNI/DIR hearing aids were more likely than other listeners to favor the DIR mode in instances where mSTMI scores only slightly favored DIR processing. Conclusions: A direct-comparison approach to OMNI/DIR mode selection was generally successful in predicting user preferences in a range of listening environments. Future modifications to the approach to further improve predictive accuracy are discussed. C1 [Summers, Van; Grant, Ken W.; Walden, Brian E.; Cord, Mary T.; Surr, Rauna K.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Elhilali, Mounya] Univ Maryland, Syst Res Inst, College Pk, MD 20742 USA. RP Summers, V (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM vsummers6@gmail.com RI Elhilali, Mounya/A-3396-2010 OI Elhilali, Mounya/0000-0003-2597-738X NR 29 TC 1 Z9 1 U1 0 U2 1 PU AMER ACAD AUDIOLOGY PI RESTON PA 11730 PLAZA DR, STE 300, RESTON, VA 20190 USA SN 1050-0545 J9 J AM ACAD AUDIOL JI J. Am. Acad. Audiol. PD OCT PY 2008 VL 19 IS 9 BP 708 EP 720 DI 10.3766/jaaa.19.9.6 PG 13 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA 419CV UT WOS:000264197600006 PM 19418710 ER PT J AU Bergeron, M AF Bergeron, Melissa TI C. I. Lewis in Focus: The Pulse of Pragmatism SO JOURNAL OF THE HISTORY OF PHILOSOPHY LA English DT Book Review C1 [Bergeron, Melissa] US Mil Acad, West Point, NY 10996 USA. RP Bergeron, M (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV PRESS PI BALTIMORE PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD 21218-4363 USA SN 0022-5053 J9 J HIST PHILOS JI J. Hist. Philos. PD OCT PY 2008 VL 46 IS 4 BP 651 EP 652 PG 2 WC Philosophy SC Philosophy GA 358VW UT WOS:000259946600023 ER PT J AU Zhang, H Ramesh, KT Chin, ESC AF Zhang, H. Ramesh, K. T. Chin, E. S. C. TI A multi-axial constitutive model for metal matrix composites SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article DE multi-axial loading; constitutive model; metal matrix composite; strength asymmetry; viscoplasticity ID RESIDUAL-STRESSES; MECHANICAL RESPONSE; ALUMINUM-MATRIX; HIGH-RATES; BEHAVIOR; DEFORMATION; STRAIN; MMC AB Metal matrix composites (MMCs) generally do not follow the classical plasticity theory, even though the matrix metals do deform plastically. A tens ion-compression yield asymmetry is typically observed in MMCs. For particulate-reinforced MMCs, this non-classical response is mainly due to the variation of damage evolution with loading modes. In this paper, a viscoplastic multi-axial constitutive model for plastic deformation of MMCs is constructed using the Mises-Schleicher yield criterion. The subsequent plastic flow is characterized by an associated and decomposed flow rule considering effects from both deviatoric and hydrostatic stresses. This model is capable of describing the multi-axial yield and flow behavior of MMCs by using simulated or measured asymmetric tensile and compressive stress-strain responses as input. As an example, the influence of damage evolution in terms of interfacial debonding in MMCs (obtained from FEM simulations) is incorporated through the different tensile and compressive stress-strain behaviors. Applying this model to predict the torsion and the pressure-dependant tensile responses of some commonly used MMCs provides good agreement with experimental data. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Zhang, H.; Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. [Chin, E. S. C.] Weap & Mat Res Directorate, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, H (reprint author), Univ Texas Austin, Ctr Mech Solids Struct & Mat, Austin, TX 78712 USA. EM htzhang@mail.utexas.edu FU US Army Research Laboratory [DAAL01-96-2-0047]; ARMAC-RTP Cooperative [DAAD19-01-2-0003] FX This work was supported by the US Army Research Laboratory through Grant No. DAAL01-96-2-0047 and ARMAC-RTP Cooperative Agreement No. DAAD19-01-2-0003. This work was performed under the auspices of the Center for Advanced Metallic and Ceramic Systems (CAMCS) at the Johns Hopkins University. The authors wish to thank the reviewers for their constructive comments. NR 30 TC 9 Z9 9 U1 2 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-5096 EI 1873-4782 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD OCT PY 2008 VL 56 IS 10 BP 2972 EP 2983 DI 10.1016/j.jmps.2008.07.001 PG 12 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA 357FQ UT WOS:000259832100003 ER PT J AU Hess, JR Brohi, K Dutton, RP Hauser, CJ Holcomb, JB Kluger, Y Mackway-Jones, K Parr, MJ Rizoli, SB Yukioka, T Hoyt, DB Bouillon, B AF Hess, John R. Brohi, Karim Dutton, Richard P. Hauser, Carl J. Holcomb, John B. Kluger, Yoram Mackway-Jones, Kevin Parr, Michael J. Rizoli, Sandro B. Yukioka, Tetsuo Hoyt, David B. Bouillon, Bertil TI The Coagulopathy of Trauma: A Review of Mechanisms SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Coagulopathy; Trauma; Shock; Mechanism; Review ID FRACTURE/SOFT-TISSUE HEMATOMAS; LIFE-THREATENING COAGULOPATHY; ISOLATED HEAD-INJURY; ACTIVATED PROTEIN-C; FRESH-FROZEN PLASMA; MAJOR TRAUMA; BRAIN-INJURY; COMBAT CASUALTIES; PLASMINOGEN-ACTIVATOR; INTRAVASCULAR COAGULATION AB Background: Bleeding is the most frequent cause of preventable death after severe injury. Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined. Methods: Articles addressing the causes and consequences of trauma-associated coagulopathy were identified and reviewed. Clinical situations in which the various mechanistic causes are important were sought along with quantitative estimates of their importance. Results: Coagulopathy associated with traumatic injury is the result of multiple independent but interacting mechanisms. Early coagulopathy is driven by shock and requires thrombin generation from tissue injury, as an initiator. Initiation of coagulation occurs with activation of anticoagulant and fibrinolytic pathways. This Acute Coagulopathy of Trauma-Shock is altered by subsequent events and medical therapies, in particular acidemia, hypothermia, and dilution. There is significant interplay between all mechanisms. Conclusions: There is limited understanding of the mechanisms by which tissue trauma, shock, and inflammation initiate trauma coagulopathy. Acute Coagulopathy of Trauma-Shock should be considered distinct from disseminated intravascular coagulation as described in other conditions. Rapid diagnosis and directed interventions are important areas for future research. C1 [Hess, John R.] Univ Maryland, Med Ctr, Dept Pathol, Baltimore, MD 21201 USA. [Brohi, Karim] Royal London Hosp, Dept Trauma Surg, London E1 1BB, England. [Dutton, Richard P.] Univ Maryland, Sch Med, Ctr Shock Trauma, Baltimore, MD 21201 USA. [Hauser, Carl J.] Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MD USA. [Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kluger, Yoram] Rambam Med Ctr, Dept Surg, Haifa, Israel. [Mackway-Jones, Kevin] Manchester Royal Infirm, Dept Emergency Med, Manchester M13 9WL, Lancs, England. [Parr, Michael J.] Univ New S Wales, Intens Care Unit, Liverpool Hosp, Sydney, NSW, Australia. [Rizoli, Sandro B.] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. [Yukioka, Tetsuo] Tokyo Med Univ, Dept Emergency & Crit Care Med, Tokyo, Japan. [Hoyt, David B.] Univ Calif Irvine, Dept Surg, Irvine, CA 92717 USA. [Bouillon, Bertil] Univ Witten Herdecke, Dept Trauma & Orthoped Surg, Cologne Merheim Med Ctr, Cologne, Germany. RP Hess, JR (reprint author), Univ Maryland, Med Ctr, Dept Pathol, Baltimore, MD 21201 USA. EM jhess@umm.edu FU Physicians World GmbH, Mannheirn, Germany; Novo Nordisk A/S. Bagsvaerd. Denmark FX Support for structured literature searches. meeting Organization and medical writing Support for article preparation were provided by Physicians World GmbH, Mannheirn, Germany. Costs incurred for travel, hotel accomodation. meeting facilities. honoraria. remote communication. The development and implementation of the literature retrieval described here and article preparation were supported by Unrestricted educational grants from Novo Nordisk A/S. Bagsvaerd. Denmark. NR 95 TC 398 Z9 428 U1 5 U2 35 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2008 VL 65 IS 4 BP 748 EP 754 DI 10.1097/TA.0b013e181877a9c PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 361JS UT WOS:000260124500002 PM 18849786 ER PT J AU Hoyt, DB Dutton, RP Hauser, CJ Hess, JR Holcomb, JB Kluger, Y Mackway-Jones, K Parr, MJ Rizoli, SB Yukioka, T Bouillon, B AF Hoyt, David B. Dutton, Richard P. Hauser, Carl J. Hess, John R. Holcomb, John B. Kluger, Yoram Mackway-Jones, Kevin Parr, Michael J. Rizoli, Sandro B. Yukioka, Tetsuo Bouillon, Bertil TI Management of Coagulopathy in the Patients With Multiple Injuries: Results From an International Survey of Clinical Practice SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Trauma; Coagulopathy; Clinical practice; Survey ID VITRO THROMBELASTOGRAPHY MEASUREMENTS; DILUTIONAL HYPOTHERMIC COAGULOPATHY; ACUTE TRAUMATIC COAGULOPATHY; DAMAGE CONTROL RESUSCITATION; FRESH-FROZEN PLASMA; VIVO BLEEDING-TIME; MASSIVE TRANSFUSION; BLOOD-TRANSFUSION; PROTHROMBIN TIME; SHOCK SEVERITY AB Background: Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly. Methods: A qualitative international survey of clinical practice among senior physicians responsible for the treatment of patients with multiple injuries (Injury Severity Score 2:16) was conducted to document common practices, highlight the variabilities, and profile the rationale behind existing clinical practices around the world. Results: Survey results are based on 80 (32%) completed returns, representing 25 countries with 93% of respondents employed by trauma centers and a mean of 20 years clinical experience. There are regional differences in the clinical specialty of physicians responsible for trauma management decisions. Blood loss, temperature, pH, platelets, prothrombin time/INR/activated partial thromboplastin time, and overall clinical assessment, were the most common criteria used to assess coagulopathy. Forty-five percent of respondents claimed to follow a massive transfusion protocol in their institution, 19% reported inconsistent protocol use and 34% do not use a protocol. The management of hypothermia, acidosis, blood products, and adjuvant therapy showed regional as well as institutional variability, and surprisingly few massive transfusion protocols specifically address these issues. Conclusion: The results of this survey may serve to draw attention to the need for a common definition of coagulopathy and standardized clinical protocols to ensure optimal patient care. C1 [Hoyt, David B.] Univ Calif Irvine, Dept Surg, Irvine, CA 92717 USA. [Dutton, Richard P.] Univ Maryland, Sch Med, Ctr Shock Trauma, Baltimore, MD 21201 USA. [Hauser, Carl J.] Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MD USA. [Hess, John R.] Univ Maryland, Med Ctr, Dept Pathol, Baltimore, MD 21201 USA. [Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kluger, Yoram] Rambam Med Ctr, Dept Surg B, Haifa, Israel. [Mackway-Jones, Kevin] Manchester Royal Infirm, Dept Emergency Med, Manchester M13 9WL, Lancs, England. [Parr, Michael J.] Univ New S Wales, Intens Care Unit, Liverpool Hosp, Sydney, NSW, Australia. [Rizoli, Sandro B.] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. [Yukioka, Tetsuo] Tokyo Med Univ, Dept Emergency & Crit Care Med, Tokyo, Japan. [Bouillon, Bertil] Univ Witten Herdecke, Cologne Merheim Med Ctr, Dept Trauma & Orthoped Surg, Cologne, Germany. RP Hoyt, DB (reprint author), Univ Calif Irvine, Dept Surg, City Tower,333 City Blvd,Suite 700, Orange, CA 92868 USA. EM dhoyt@uci.edu RI Hess, John/K-4001-2013 OI Hess, John/0000-0001-8596-4420 FU Physicians World GmbH, Mannheim, Germany; Novo Nordisk A/S. Bagsvaerd, Denmark FX Support for survey development and implementation, meeting organization and medical writing support for article preparation were provided by Physicians World GmbH, Mannheim, Germany. Costs incurred for travel, hotel accommodation, meeting facilities, honoraria, Survey implementation, and preparation of the article were supported by unrestricted educational grants from Novo Nordisk A/S. Bagsvaerd, Denmark. B.B. has received honoraria for consulting or lecturing and research funding from Novo Nordisk. NR 25 TC 73 Z9 80 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2008 VL 65 IS 4 BP 755 EP 764 DI 10.1097/TA.0b013e1815a9f PG 10 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 361JS UT WOS:000260124500003 PM 18849787 ER PT J AU Parr, MJ Bouillon, B Brohi, K Dutton, RP Hauser, CJ Hess, JR Holcomb, JB Kluger, Y Mackway-Jones, K Rizoli, SB Yukioka, T Hoyt, DB AF Parr, Michael J. Bouillon, Bertil Brohi, Karim Dutton, Richard P. Hauser, Carl J. Hess, John R. Holcomb, John B. Kluger, Yoram Mackway-Jones, Kevin Rizoli, Sandro B. Yukioka, Tetsuo Hoyt, David B. TI Traumatic Coagulopathy: Where are the Good Experimental Models? SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Review DE Coagulopathy; Trauma; Experimental models; Review ID DISSEMINATED INTRAVASCULAR COAGULATION; RECOMBINANT FACTOR VIIA; V LIVER-INJURIES; VON-WILLEBRAND-DISEASE; DECREASES BLOOD-LOSS; FIBRINOGEN METABOLISM; ANIMAL-EXPERIMENTS; ASPHYXIAL SHOCK; DILUTIONAL COAGULOPATHY; NONCOAGULOPATHIC PIGS AB Background The development of coagulopathy associated with trauma is a complex process that involves a combination of many factors. It is important to be able to model experimental trauma-related coagulopathy to explore preventative and therapeutic strategies, and numerous models of traumatic coagulopathy have been explored. This systematic review assessed the primary question "What are relevant experimental models with which to study early traumatic coagulopathy?" and secondary questions on mechanisms. Methods: The author group reviewed 695 abstracts that resulted in 36 articles being fully reviewed by the group. The group identified 12 key studies (grade A) addressing the primary question. A further 10 articles were thought to be relevant but less important (grade B). Eight articles were considered worthwhile publications but not as relevant to the query (grade Q, and six articles were considered not relevant after detailed review (grade D). Results: This structured literature review demonstrated a lack of relevant models for human traumatic coagulopathy. We identify challenges in modeling traumatic coagulopathy and limitations to current experimental models and include a proposal for features of an "ideal" model of traumatic coagulopathy, but recognize that this involves major challenges. Conclusions: Models of traumatic coagulopathy need to more closely resemble human physiology and real-life conditions if they are to influence clinical practice. C1 [Parr, Michael J.] Univ New S Wales, Intens Care Unit, Liverpool Hosp, Sydney, NSW 1871, Australia. [Bouillon, Bertil] Univ Witten Herdecke, Dept Trauma & Orthoped Surg, Cologne Merheim Med Ctr, Cologne, Germany. [Brohi, Karim] Royal London Hosp, Dept Trauma Surg, London E1 1BB, England. [Dutton, Richard P.] Univ Maryland, Sch Med, Ctr Shock Trauma, Baltimore, MD 21201 USA. [Hauser, Carl J.] Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02215 USA. [Hess, John R.] Univ Maryland, Med Ctr, Dept Pathol, Baltimore, MD 21201 USA. [Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kluger, Yoram] Rambam Med Ctr, Dept Surg B, Haifa, Israel. [Mackway-Jones, Kevin] Manchester Royal Infirm, Dept Emergency Med, Manchester M13 9WL, Lancs, England. [Rizoli, Sandro B.] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada. [Yukioka, Tetsuo] Tokyo Med Univ, Dept Emergency & Crit Care Med, Tokyo, Japan. [Hoyt, David B.] Univ Calif Irvine, Dept Surg, Irvine, CA 92717 USA. RP Parr, MJ (reprint author), Univ New S Wales, Intens Care Unit, Liverpool Hosp, Locked Bag 7103, Sydney, NSW 1871, Australia. EM michael.parr@swsahs.nsw.gov.au RI Hess, John/K-4001-2013 OI Hess, John/0000-0001-8596-4420 FU Physicians World GmbH. Mnnheim, Germany; Novo Nordisk A/S, Bagsvaerd. Denmark. FX Support for structured literature searches, meeting organization, and medical writing support for article preparation were provided by Physicians World GmbH. Mnnheim, Germany. Costs incurred for travel, hotel accomodation, rneeting facilities, honoraria. remote communication and article preparation were Supported by unrestricted educational grants front Novo Nordisk A/S, Bagsvaerd. Denmark. NR 49 TC 33 Z9 34 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2008 VL 65 IS 4 BP 766 EP 771 DI 10.1097/TA.0b013e31818606d2 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 361JS UT WOS:000260124500005 PM 18849788 ER PT J AU Cancio, LC Batchinsky, AI Salinas, J Kuusela, T Convertino, VA Wade, CE Holcomb, JB AF Cancio, Leopoldo C. Batchinsky, Andriy I. Salinas, Jose Kuusela, Tom Convertino, Victor A. Wade, Charles E. Holcomb, John B. TI Heart-Rate Complexity for Prediction of Prehospital Lifesaving Interventions in Trauma Patients SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Heart rate; Electrocardiography; Nonlinear dynamics; Spectrum; analysis; Transportation of patients ID ACUTE MYOCARDIAL-INFARCTION; R INTERVAL DYNAMICS; RATE-VARIABILITY; ATRIAL-FIBRILLATION; PERIOD VARIABILITY; HEMORRHAGIC-SHOCK; MORTALITY; PRESSURE; ICU AB Background: Traditional vital signs often fail to identify critically injured patients soon enough to permit timely intervention. To improve our ability to forecast the need for prehospital lifesaving interventions (LSIs), we applied heart-rate complexity (HRC) analysis to the electrocardiogram (ECG) of patients en route to trauma centers. Methods: Analysis of ECG and clinical data from 374 patients en route by helicopter to three urban Level I trauma centers was conducted. Waveforms from 182 patients were excluded (because of ectopy, noise, or inadequate length). Of the remaining 192 patients, 54 received 66 LSIs in the field (LSI group): intubation (n = 52), cardiopulmonary resuscitation (n = 5), cricothyroidotomy (n = 2), and pneumothorax decompression (n = 7); 138 patients did not (non-LSI group). In the field, heart rate, blood pressure, and the Glasgow Coma Scale score (GCS(TOTAL)) and its motor component (GCS(MOTOR)) were recorded. ECG was recorded during flight. Ectopy-free, 800-beat sections of ECG were identified off-line and analyzed by HRC methods including Sample Entropy (SampEn) and Detrended Fluctuations Analysis (DFA). Results: There was no difference between LSI and non-LSI patients in heart rate or blood pressure. SampEn was lower in LSI than in non-LSI (0.88 +/- 0.03 vs. 1.11 +/- 0.03), as was DFA (1.09 +/- 0.05 vs. 1.33 +/- 0.03) and GCS(MOTOR) (3.4 +/- 0.4 vs. 5.7 +/- 0.1) (all p < 0.000 1). By logistic regression, SampEn, DFA, and GCS(MOTOR) were independently associated with LSIs (area under the receiver operating characteristic curve, 0.897). Conclusions: Decreased HRC is associated with LSIs in prehospital trauma patients. HRC may be useful as a new vital sign for identification of the severely injured. C1 [Cancio, Leopoldo C.; Batchinsky, Andriy I.; Salinas, Jose; Convertino, Victor A.; Wade, Charles E.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Kuusela, Tom] Univ Turku, Dept Phys, SF-20500 Turku, Finland. RP Cancio, LC (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM lee.cancio@amedd.army.mil NR 36 TC 58 Z9 62 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2008 VL 65 IS 4 BP 813 EP 819 DI 10.1097/TA.0b013e3181848241 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 361JS UT WOS:000260124500013 PM 18849796 ER PT J AU Reisner, AT Chen, LY McKenna, TM Reifman, J AF Reisner, Andrew T. Chen, Liangyou McKenna, Thomas M. Reifman, Jaques TI Automatically-Computed Prehospital Severity Scores are Equivalent to Scores Based on Medic Documentation SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article DE Remote triage; Monitoring; Trauma score; Vital signs; Signal quality ID CHARACTERISTIC ROC CURVES; TRAUMA SCORE; TRIAGE; SYSTEM; ALGORITHMS; MORTALITY; TRANSPORT; SCALE AB Background: Prehospital severity scores can be used in routine prehospital care, mass casualty care, and military triage. If computers could reliably calculate clinical scores, new clinical and research methodologies would be possible. One obstacle is that vital signs measured automatically can be unreliable. We hypothesized that Signal Quality Indices (SQI's), computer algorithms that differentiate between reliable and unreliable monitored physiologic data, could improve the predictive power of computer-calculated scores. Methods: In a retrospective analysis of trauma casualties transported by air ambulance, we computed the Triage Revised Trauma Score (RTS) from archived travel monitor data. We compared the areas-under-the-curve (AUC's) of receiver operating characteristic curves for prediction of mortality and red blood cell transfusion for 187 subjects with comparable quantities of good-quality and poor-quality data. Results. Vital signs deemed reliable by SQI's led to significantly more discriminatory severity scores than vital signs deemed unreliable. We also compared automatically-computed RTS (using the SQI's) versus RTS computed from vital signs documented by medics. For the subjects in whom the SQI algorithms identified 15 consecutive seconds of reliable vital signs data (n = 350), the automatically-computed scores' AUC's were the same as the medic-based scores' AUC's. Using the Prehospital Index in place of RTS led to very similar results, corroborating our findings. Conclusions: SQI algorithms improve automatically-computed severity scores, and automatically-computed scores using SQI's are equivalent to medic-based scores. C1 [Reifman, Jaques] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA. [Reisner, Andrew T.; Chen, Liangyou; McKenna, Thomas M.; Reifman, Jaques] USA, Med Res & Mat Command, TATRC, Ft Detrick, MD USA. RP Reisner, AT (reprint author), Massachusetts Gen Hosp, Dept Emergency Med, Zero Emerson Pl,Suite 3B, Boston, MA 02114 USA. EM areisner@partners.org FU Combat Casualty Care Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD FX Supported by the Combat Casualty Care Directorate of the U.S. Army Medical Research and Materiel Command, Fort Detrick, MD. NR 40 TC 19 Z9 19 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD OCT PY 2008 VL 65 IS 4 BP 915 EP 923 DI 10.1097/TA.0b013e31815eb142 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 361JS UT WOS:000260124500035 PM 18849811 ER PT J AU Chen, JP Hathaway, MD Herrick, GP AF Chen, Jen-Ping Hathaway, Michael D. Herrick, Gregory P. TI Prestall behavior of a transonic axial compressor stage via time-accurate numerical simulation SO JOURNAL OF TURBOMACHINERY-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 52nd ASME Turbo Expo 2007 CY MAY 14-17, 2007 CL Montreal, CANADA SP Amer Soc Mech Engineers, Int Gas Turbine Inst ID STALL INCEPTION; ROTATING-STALL AB Computational fluid dynamics calculations using high-performance parallel computing were conducted to simulate the prestall flow of a transonic compressor stage, NASA compressor Stage 35. The simulations were run with a full-annulus grid that models the 3D, viscous, unsteady blade row interaction without the need for an artificial inlet distortion to induce stall. The simulation demonstrates the development of the rotating stall from the growth of instabilities. Pressure rise performance and pressure traces are compared with published experimental data before the study of flow evolution prior to the rotating stall. Spatial fast Fourier transform analysis of the flow indicates a rotating long-length disturbance of one rotor circumference, which is followed by a spike-type breakdown. The analysis also links the long-length wave disturbance with the initiation of the spike inception. The spike instabilities occur when the trajectory of the tip clearance flow becomes perpendicular to the axial direction. When approaching stall, the passage shock changes from a single oblique shock to a dual shock, which distorts the perpendicular trajectory of the tip clearance vortex but shows no evidence of flow separation that may contribute to stall. C1 [Chen, Jen-Ping] Ohio State Univ, Columbus, OH 43210 USA. [Hathaway, Michael D.; Herrick, Gregory P.] USA, Res Lab, Vehicle Technol Directorate, Cleveland, OH 44135 USA. RP Chen, JP (reprint author), Ohio State Univ, Columbus, OH 43210 USA. NR 27 TC 24 Z9 24 U1 1 U2 7 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0889-504X J9 J TURBOMACH JI J. Turbomach.-Trans. ASME PD OCT PY 2008 VL 130 IS 4 AR 041014 DI 10.1115/1.2812968 PG 12 WC Engineering, Mechanical SC Engineering GA 334NW UT WOS:000258229500014 ER PT J AU Johnson, ON Slidell, MB Macsata, RA Faler, BJ Amdur, RL Sidawy, AN AF Johnson, Owen N., III Slidell, Mark B. Macsata, Robyn A. Faler, Byron J. Amdur, Richard L. Sidawy, Anton N. TI Outcomes of surgical management for popliteal artery aneurysms: An analysis of 583 cases SO JOURNAL OF VASCULAR SURGERY LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the Society-for-Clinical-Vascular-Surgery CY MAR 05-08, 2008 CL Las Vegas, NV SP Soc Clin Vasc Surg ID TERM FOLLOW-UP; EXPERIENCE; SUCCESS; BYPASS; REPAIR AB Background: This study aimed to analyze outcomes of surgical management for popliteal artery aneurysms (PAA). Methods: This is a retrospective analysis of prospectively collected data regarding operations for PAA obtained from 123 United States Veterans Affairs Medical Centers as part of the National Surgical Quality Improvement Program. Univariate analyses and multivariate logistic regression were used to characterize 33 risk factors and their associations with 30-day morbidity and mortality. Survival and amputation rates, observed at one and two years after surgery, were subject to life-table and Cox regression analyses. Results. There were 583 operations for PAA in 537 patients during 1994-2005. Almost all were in men (99.8%) and median age was 69 years (range, 34 to 92 years). Most had multiple co-morbidities, 88% were ASA (American Society of Anesthesiologists) class 3 or 4, and 81% were current or past smokers (median pack-years = 50). Only 16% were diabetic. Serious complications occurred in 69 (11.8%) cases, of which 37 (6.3%) required arterial-specific reinterventions. Eight patients died within 30 days, a mortality of 1.4%. Risk factors associated with increased complications included: African-American race (odds ratio [OR] 2.8 [95% confidence interval 1.5-5.2], P = .002), emergency surgery (OR 3.8 [2.0-7.0], P < .0001), ASA 4 (OR 1.9 [1.1-3.5], P = .04), dependent functional status (OR 2.5 [1.4-4.7], P = .004), steroid use (OR 3.2 [1.2-8.71, P = .03), and need for intraoperative red blood cell transfusion of any quantity (OR 6.3 [3.5-11.2], P < .0001). Independent predictors for complications in the multivariate model were dependent functional status (adjusted OR 2.1 [1.1-4.3], P = .049) and intraoperative transfusion (adjusted OR 4.5 [2.3-8.9], P = .0002). Postoperative bleeding complications within 72 hours independently predicted early amputation (adjusted OR 25.5 [1.7-393], P = .02). Unadjusted patient survival was 92.6% at one year and 86.1% at two years. Limb salvage in surviving patients was 99.0% at 30 days, 97.6% at one year, and 96.2% at two years. Dependent preoperative functional status was the only factor predictive of worse two-year limb salvage (adjusted OR 4.6 [1.9-10.9], P = .001), but remained high at 88.2% versus 97.1% in independent patients. Conclusions: Surgical intervention for PAA is associated with low operative mortality and offers excellent two-year limb salvage, even in high-risk patients. Patients' preoperative functional status and perioperative blood transfusion requirements were the most predictive indicators of negative outcomes. C1 [Johnson, Owen N., III; Slidell, Mark B.; Macsata, Robyn A.; Faler, Byron J.; Amdur, Richard L.; Sidawy, Anton N.] Vet Affairs Med Ctr, Dept Surg Serv, Washington, DC 20422 USA. [Johnson, Owen N., III; Faler, Byron J.] Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. [Slidell, Mark B.; Sidawy, Anton N.] Georgetown Univ, Dept Surg, Washington, DC USA. [Sidawy, Anton N.] George Washington Univ, Dept Surg, Washington, DC USA. RP Sidawy, AN (reprint author), 50 Irving St,NW 112, Washington, DC 20422 USA. EM ansidawy@aol.com OI Johnson III, Owen/0000-0001-6497-1285 NR 27 TC 19 Z9 19 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0741-5214 J9 J VASC SURG JI J. Vasc. Surg. PD OCT PY 2008 VL 48 IS 4 BP 845 EP 851 DI 10.1016/j.jvs.2008.05.063 PG 7 WC Surgery; Peripheral Vascular Disease SC Surgery; Cardiovascular System & Cardiology GA 353NR UT WOS:000259575200011 PM 18639422 ER PT J AU Sadon, N Delers, A Jarman, RG Klungthong, C Nisalak, A Gibbons, RV Vassilev, V AF Sadon, Nadine Delers, Anne Jarman, Richard G. Klungthong, Chonticha Nisalak, Ananda Gibbons, Robert V. Vassilev, Ventzislav TI A new quantitative RT-PCR method for sensitive detection of dengue virus in serum samples SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE dengue virus; serotype; quantitative RT-PCR; serum ID LINKED-IMMUNOSORBENT-ASSAY; HEMORRHAGIC-FEVER; RAPID DETECTION; JAPANESE ENCEPHALITIS; TRANSCRIPTASE; INFECTIONS; DIAGNOSIS; DISEASE; BANGKOK AB In order to detect and identify dengue serotypes in serum samples, we developed a single-step quantitative reverse transcription-polymerase chain reaction (Q-RT-PCR) assay (referred to as Q-PCR). Sets of primers were selected from the capsid region of the viral genome. Dengue serotypes 1/3 and 2/4 were detected in two separate duplex amplification reactions using specific primers and fluorogenic TaqMan (TM) probes. Results obtained with this Q-PCR and the classical nested RT-PCR (N-PCR) assays were compared using a panel of 97 representative human sera collected from patients in Bangkok, Thailand. It is shown that the Q-PCR is a rapid, sensitive and reproducible tool for the detection and quantitation of the four dengue serotypes in clinical samples, and therefore of great interest for diagnostic use or for large cohort studies. (C) 2008 Elsevier B.V. All rights reserved. C1 [Sadon, Nadine; Delers, Anne; Vassilev, Ventzislav] GlaxoSmithKline Biol, Res & Dev, Viral Vaccines, B-1330 Rixensart, Belgium. [Jarman, Richard G.; Klungthong, Chonticha; Nisalak, Ananda; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. RP Vassilev, V (reprint author), GlaxoSmithKline Biol, Res & Dev, Viral Vaccines, Rue Inst,89 P21-005, B-1330 Rixensart, Belgium. EM ventzislav.vassilev@gskbio.com FU United States Army Medical Research and Materiel Command (Fort Detrick, Frederick, MD); GlaxoSmithKline Biologicals (Rixensart, Belgium) FX This work was funded by the United States Army Medical Research and Materiel Command (Fort Detrick, Frederick, MD) and GlaxoSmithKline Biologicals (Rixensart, Belgium). NR 26 TC 29 Z9 31 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD OCT PY 2008 VL 153 IS 1 BP 1 EP 6 DI 10.1016/j.jviromet.2008.06.023 PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA 350GH UT WOS:000259340200001 PM 18652847 ER PT J AU Piruska, A Branagan, S Cropek, DM Sweedler, JV Bohn, PW AF Piruska, Aigars Branagan, Sean Cropek, Donald M. Sweedler, Jonathan V. Bohn, Paul W. TI Electrokinetically driven fluidic transport in integrated three-dimensional microfluidic devices incorporating gold-coated nanocapillary array membranes SO LAB ON A CHIP LA English DT Article ID SELF-ASSEMBLED MONOLAYERS; NANOTUBULE MEMBRANES; ION-TRANSPORT; SURFACE; FABRICATION; LIGHT; ELECTROPHORESIS; IMMOBILIZATION; DESORPTION; BEHAVIOR AB Electrokinetically driven fluid transport was evaluated within three-dimensional hybrid nanofluidic-microfluidic devices incorporating Au-coated nanocapillary array membranes (NCAMs). Gold NCAMs, prepared by electroless gold deposition on polymeric track-etched membranes, were susceptible to gas bubble formation if the interfacial potential difference exceeded similar to 2 V along the length of the gold region. Gold membranes were etched to yield 250 Pm wide coated regions that overlap the intersection of two orthogonal microfluidic channels in order to minimize gas evolution. The kinetics of electrolysis of water at the opposing ends of the gold region was modeled and found to be in satisfactory agreement with experimental measurements of the onset of gas bubble formation. Conditions to achieve electrokinetic injection across Au-coated NCAMs were identified, with significant reproducible injections being possible for NCAMs modified with this relatively thin gold stripe. Continuous gold films led to suppressed injections and to a variety of ion enrichment/depletion effects in the microfluidic source channel. The suppression of injections was understood through finite element modeling which revealed the presence of a significant electrophoretic velocity component in opposition to electroosmotic flow at the edge of the Au-dielectric regions. C1 [Piruska, Aigars; Branagan, Sean; Bohn, Paul W.] Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA. [Cropek, Donald M.] USA, Engn Res & Dev Ctr, Champaign, IL 61826 USA. [Sweedler, Jonathan V.] Univ Illinois, Dept Chem, Urbana, IL 61801 USA. RP Bohn, PW (reprint author), Univ Notre Dame, Dept Chem & Biomol Engn, Notre Dame, IN 46556 USA. EM pbohn@nd.edu RI Sweedler, Jonathan/A-9405-2009 OI Sweedler, Jonathan/0000-0003-3107-9922 FU Strategic Environmental Research and Development Program; Department of Energy [DE FG02 07ER15851] FX Funding by the Strategic Environmental Research and Development Program and by the Department of Energy grant DE FG02 07ER15851 is gratefully acknowledged. NR 31 TC 18 Z9 18 U1 1 U2 12 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND SN 1473-0197 J9 LAB CHIP JI Lab Chip PD OCT PY 2008 VL 8 IS 10 BP 1625 EP 1631 DI 10.1039/b805768k PG 7 WC Biochemical Research Methods; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology SC Biochemistry & Molecular Biology; Chemistry; Science & Technology - Other Topics GA 366FP UT WOS:000260466300004 PM 18813383 ER PT J AU Kumar, A Stephenson, LD Bushman, JB AF Kumar, Ashok Stephenson, L. D. Bushman, James B. TI Impressed Current Cathodic Protection of Hot Water Storage Tanks SO MATERIALS PERFORMANCE LA English DT Article AB Six pressurized steel hot water storage tanks at an Army installation were fitted with impressed current cathodic protection (ICCP). The design of the system took into account the water chemistry and current density required to mitigate corrosion at the operating temperature of up to 60 degrees C (140 degrees F). ICCP is expected to create a substantial service life extension and a reduction in the chance of leakage. C1 [Kumar, Ashok] USA, Erdc, CERL, Champaign, IL 61826 USA. [Bushman, James B.] Bushman & Associates Inc, Medina, OH 44256 USA. RP Kumar, A (reprint author), USA, Erdc, CERL, POB 9005, Champaign, IL 61826 USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU NATL ASSOC CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD OCT PY 2008 VL 47 IS 10 BP 27 EP 31 PG 5 WC Materials Science, Characterization & Testing SC Materials Science GA 358SS UT WOS:000259938400007 ER PT J AU Yu, GL Borlongan, CV Stahl, CE Yu, SJ Bae, E Yang, TL Zhou, JY Li, Y Xiong, W Qin, LQ Zhou, B AF Yu, Guolong Borlongan, Cesar V. Stahl, Christine E. Yu, Seong Jin Bae, Eunkyung Yang, Tianlun Zhou, Jiyang Li, Yuan Xiong, Wei Qin, Liqion Zhou, Bo TI Transplantation of human umbilical cord blood cells for the repair of myocardial infarction SO MEDICAL SCIENCE MONITOR LA English DT Review DE stem cells; transplantation; hematopoietic cells; cardiomyocyte; differentiation ID ENDOTHELIAL PROGENITOR CELLS; HEMATOPOIETIC STEM-CELLS; IMPROVE CARDIAC-FUNCTION; CORONARY-ARTERY-DISEASE; MONONUCLEAR-CELLS; PERIPHERAL-BLOOD; CELLULAR CARDIOMYOPLASTY; HEART-FAILURE; CD34(+) CELLS; RAT MODEL AB Cell therapy for myocardial disease is a rapidly evolving medical field. A vast and growing body of evidence indicates that cell-based strategies have promising therapeutic potential. Recent clinical and pre-clinical studies demonstrate a varying degree of improvement in cardiac function using different sources of adult stem cell types such as bone marrow-derived progenitor cells and skeletal myoblasts. However, the currently available regimens for cell transplantation into the infarcted myocardium have limitations from practical points of view, in particular the logistics in harvesting donor cells. According, there is an urgent need for a new source of adult stem cells. Human umbilical cord blood (HUCB) is a good candidate and appears to have several key advantages. HUCB is a viable and practical source of progenitor cells. Compared to bone marrow. HUCB contains a higher number of immature stem/progenitor cells. The aim of our review is to provide and update on the preclinical experiments with emphasis on the possible mechanisms underlying the therapeutic benefits of HUCB cell transplantation for myocardial infarction. C1 [Yu, Guolong; Yang, Tianlun; Zhou, Jiyang; Li, Yuan; Xiong, Wei; Qin, Liqion; Zhou, Bo] So Cent Univ, Xiangya Hosp, Dept Cardiol, Changsha 410078, Hunan, Peoples R China. [Borlongan, Cesar V.; Yu, Seong Jin; Bae, Eunkyung] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA. [Stahl, Christine E.] Dwight D Eisenhower Army Med Ctr, Dept Internal Med, Ft Gordon, GA USA. RP Yu, GL (reprint author), So Cent Univ, Xiangya Hosp, Dept Cardiol, Changsha 410078, Hunan, Peoples R China. EM yuguolong123@yahoo.com.cn FU National Natural Science Foundation of China; MCG Department of Neurology Funds FX support: Drs. Guolong Yu, Tianlun Yang, Jiyang Zhou, Yuan Li, Wei Xiong, Liqion Qin, Bo Zhou was supported by the National Natural Science Foundation of China. Drs. Cesar V. Borlongan, Seong Jin Yu, and Eunkyung Bae were supported by the MCG Department of Neurology Funds NR 77 TC 13 Z9 18 U1 1 U2 5 PU INT SCIENTIFIC LITERATURE, INC PI SMITHTOWN PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA SN 1234-1010 J9 MED SCI MONITOR JI Med. Sci. Monitor PD OCT PY 2008 VL 14 IS 10 BP RA163 EP RA172 PG 10 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA 372AJ UT WOS:000260873500024 PM 18830206 ER PT J AU Engel, CC Oxman, T Yamamoto, C Gould, D Barry, S Stewart, P Kroenke, K Williams, JW Dietrich, AJ AF Engel, Charles C. Oxman, Thomas Yamamoto, Christopher Gould, Darin Barry, Sheila Stewart, Patrice Kroenke, Kurt Williams, John W., Jr. Dietrich, Allen J. TI RESPECT-Mil: Feasibility of a Systems-Level Collaborative Care Approach to Depression and Post-Traumatic Stress Disorder in Military Primary Care SO MILITARY MEDICINE LA English DT Article ID RANDOMIZED CONTROLLED-TRIAL; MENTAL-HEALTH PROBLEMS; COST-EFFECTIVENESS; PANIC DISORDER; REENGINEERING SYSTEMS; OFFICE SYSTEM; INTERVENTION; AFGHANISTAN; MANAGEMENT; ATTRITION AB Background: U.S. military ground forces report high rates of war-related traumatic stressors, posttraumatic stress disorder (PTSD), and depression following deployment in support of recent armed conflicts in Iraq and Afghanistan. Affected service members do not receive needed mental health services in most cases, and they frequently report stigma and significant structural barriers to mental health services. Improvements in primary care may help address these issues, and evidence supports the effectiveness of a systems-level collaborative care approach. Objective: To test the feasibility of systems-level collaborative care for PTSD and depression in military primary care. We named our collaborative care model "Re-Engineering Systems of Primary Care for PTSD and Depression in the Military" (RESPECT-Mil). Methods: Key elements of RESPECT-Mil care include universal primary care screening for PTSD and depression, brief standardized primary care diagnostic assessment for those who screen positive, and use of a nurse "care facilitator" to ensure continuity of care for those with unmet depression and PTSD treatment needs. The care facilitator assists primary care providers with follow-up, symptom monitoring, and treatment adjustment and enhances the primary care interface with specialty mental health services. We report assessments of feasibility of RESPECT-Mil implementation in a busy primary care clinic supporting Army units undergoing frequent Iraq, Afghanistan, and other deployments. Results: Thirty primary care providers (family physicians, physician assistants, and nurse practitioners) were trained in the model and in the care of depression and PTSD. The clinic screened 4,159 primary care active duty patient visits: 404 screens (9.7%) were positive for depression, PTSD, or both. Sixty-nine patients participated in collaborative care for 6 weeks or longer, and the majority of these patients experienced clinically important improvement in PTSD and depression. Even although RESPECT-Mil participation was voluntary for providers, only one refused participation. No serious adverse events were noted. Conclusions: Collaborative care is an evidence-based approach to improving the quality of primary care treatment of anxiety and depression. Our version of collaborative care for PTSD and depression., RESPECT-Mil, is feasible, safe, and acceptable to military primary care providers and patients, and participating patients frequently showed clinical improvements. Efforts to implement and evaluate collaborative care approaches for mental disorders in Populations at high risk for psychiatric complications of military service are warranted. C1 [Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Oxman, Thomas] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Hanover, NH 03755 USA. Womack Army Med Ctr, Robinson Hlth Clin, Dept Family Practice, RESPECT Mil Ctr Excellence, Ft Bragg, NC 28310 USA. [Barry, Sheila] RESPECT Mil Ctr Excellence, Dept Army, Newbury, NH 03255 USA. [Kroenke, Kurt] Indiana Univ, Sch Med, Regenstrief Inst, Indianapolis, IN 46202 USA. [Williams, John W., Jr.] Duke Univ, Sch Med, Durham, NC 27705 USA. [Dietrich, Allen J.] DHMC, Dartmouth Med Sch, Lebanon, NH 03756 USA. RP Engel, CC (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 34 TC 67 Z9 69 U1 2 U2 15 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2008 VL 173 IS 10 BP 935 EP 940 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 360ZJ UT WOS:000260097000001 PM 19160608 ER PT J AU Dufresne, GW Wells, RD Pfaff, JA AF Dufresne, Gary W. Wells, Ryan D. Pfaff, James A. TI The Retrospective Prevalence of Community-Acquired Methicillin- Resistant Staphylococcus aureus in Soft Tissue Abscesses at Two Military Level 1 Trauma Centers SO MILITARY MEDICINE LA English DT Article ID SKIN INFECTIONS; CHILDREN; RISK AB Study objective: Many studies have shown that community-acquired methicillin-resistant Staphylococcus aureus (CAMRSA) is a very prevalent organism. However, no data have been published to date with regard to CAMRSA prevalence in patients presenting to the emergency department (ED) of a military medical facility. Our objective is to estimate the period prevalence of CAMRSA in cases of soft tissue abscesses seen in the emergency departments of two major military hospitals. Methods: A retrospective review oil electronic records was performed from January 1, 2004 to August 10, 2005. This database was used to identify patients with the diagnosis of abscess, the procedure code for incision and drainage, and Culture Of Wound. After data were accumulated, standard prevalence Calculations were applied to determine prevalence of CAMRSA in abscesses at our emergency departments. Antibiotic Susceptibilities were then evaluated with regard to the CAMRSA bacteria. Results: The prevalence at out, two emergency departments was 68% (751 abscesses, 220 cultured, 155 methicillin-resistant S. aureus (MRSA)-positive Cultures). The prevalence at Brooke Army Medical Center and Wilford Hall Medical Center emergency departments was 70% (520 abscesses, 145 cultured, and 101 MRSA positive) and 65% (231 abscesses, 75 Cultured, and 49 MRSA positive), respectively. Conclusion: The Occurrence of CAMRSA is not isolated to the civilian Population. The prevalence of CAMRSA in this Population is significant, and may pose serious operational and deployment-related ramifications requiring the attention of military medical planners as well as forward medical care providers. The probability of CAMRSA infection should be considered when treating soft tissue abscesses in the military emergency department. C1 [Dufresne, Gary W.; Pfaff, James A.] San Antonio Uniformed Serv Educ Consortium SAUSHE, Brooke Army Med Ctr, Emergency Dept, Ft Sam Houston, TX 78234 USA. [Wells, Ryan D.] San Antonio Uniformed Serv Educ Consortium SAUSHE, Wilford Hall Med Ctr, Emergency Dept, Lackland AFB, TX 78236 USA. RP Dufresne, GW (reprint author), San Antonio Uniformed Serv Educ Consortium SAUSHE, Brooke Army Med Ctr, Emergency Dept, 3851 Roger Brook Dr, Ft Sam Houston, TX 78234 USA. NR 17 TC 1 Z9 1 U1 1 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2008 VL 173 IS 10 BP 945 EP 948 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 360ZJ UT WOS:000260097000003 PM 19160610 ER PT J AU Ellis, SB Appenzeller, G Lee, H Mullen, K Swenness, R Pimentel, G Mohareb, E Warner, C AF Ellis, Shannon B. Appenzeller, George Lee, Heechoon Mullen, Keri Swenness, Ricardo Pimentel, Guillermo Mohareb, Emad Warner, Christopher TI Outbreak of SandFly Fever in Central Iraq, September 2007 SO MILITARY MEDICINE LA English DT Article ID ENDEMIC INFECTIOUS-DISEASES; US MILITARY; RESISTANCE; DIAGNOSIS; GULF AB An outbreak of nonspecific febrile illnesses Occurred among U.S. Army troops in September 2007 at a remote, newly established, rural-situated patrol base, south of Baghdad, Iraq. Soldiers displayed an acute flu-like syndrome with symptoms of fever, headache, malaise, and myalgia. A total of 14 cases was identified and treated presumptively as query fever. Subsequent convalescent serum specimens confirmed 13 (92.9%) positive for sandfly Sicilian virus and 3 (21.4%) positive for Coxiella burnetii, with two positive for both. One sandfly Sicilian virus case tested positive for Brucella spp. This outbreak emphasizes the potential for multiple simultaneous disease exposures to endemic diseases in nonindigenous military personnel at remote military locations in Iraq. Recommendations include increased theater disease surveillance, medical training, and vector control. C1 [Ellis, Shannon B.; Swenness, Ricardo] Third Infantry Div, Infantry Regiment 30, Battal 1, St Stewart, GA 31314 USA. [Lee, Heechoon] Walter Reed Army Med Ctr, Dept Prevent Med, Washington, DC 20307 USA. [Pimentel, Guillermo] USN, Med Res Unit 3, Int Emerging Infect Program, Cairo, Egypt. [Mohareb, Emad] USN, Med Res Unit 3, Serol & Field Studies Unit, Cairo, Egypt. RP Ellis, SB (reprint author), Third Infantry Div, Infantry Regiment 30, Battal 1, St Stewart, GA 31314 USA. RI Valle, Ruben/A-7512-2013; OI Pimentel, Guillermo/0000-0003-2464-1526 NR 28 TC 15 Z9 16 U1 0 U2 1 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2008 VL 173 IS 10 BP 949 EP 953 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 360ZJ UT WOS:000260097000004 PM 19160611 ER PT J AU Kemp, KR Thompson, JC Jefferson, T Ong, B Sharkey, CD Jeffries, J Nunez, L AF Kemp, Kenneth R. Thompson, Jennifer C. Jefferson, Thomas Ong, Bruce Sharkey, Christine D. Jeffries, Joseph Nunez, Lara TI Ethics Training for Military Medical Trainees: The Brooke Army Medical Center Experience SO MILITARY MEDICINE LA English DT Article ID HOUSE OFFICERS; EDUCATION; CONFIDENCE; KNOWLEDGE; ATTITUDES; STUDENTS; SCHOOLS; US AB Biomedical ethics training during graduate medical education programs is required by the Accreditation Council for Graduate Medical Education. Apart from this requirement. medical ethics education is an integral component of military medical practice. Although ethics education and training are required, tools to assess the effectiveness of ethics education are not well developed. Furthermore. although biomedical ethics education is mandated for new Army physician trainees. there has not been a systematic objective assessment of the effectiveness of that training. We report the concept underlying the design and implementation of a military biomedical ethics seminar for new Army physician trainees. Combining a didactic component and case analysis through small-group discussions, we emphasized providing tool, to analyze ethical dilemmas both in the medical center environment and in the operational medicine environment. A total of 47 Army interns participated in the seminar. Eighty-nine percent of participants agreed or strongly agreed that the ethics orientation met expectations. Seventy-two percent agreed or strongly agreed that the information presented would affect their practice. Ninety-six percent thought that the small-group discussions were effective. and 80% thought that the presentations enhanced knowledge from medical school. C1 [Kemp, Kenneth R.; Thompson, Jennifer C.; Jefferson, Thomas] Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. [Ong, Bruce] Hunter Army Airfield, Infantry Div 3, Savannah, GA 31419 USA. [Sharkey, Christine D.] William Beaumont Army Med Ctr, Dept Med, El Paso, TX 79920 USA. [Jeffries, Joseph] USA, Med Dept Ctr & Sch, Baylor Program, Ft Sam Houston, TX 78234 USA. [Nunez, Lara] Guantanamo Joint Task Force 525 Mil Police Battal, APO, AE 09360 USA. RP Kemp, KR (reprint author), Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. NR 28 TC 4 Z9 4 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2008 VL 173 IS 10 BP 968 EP 974 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 360ZJ UT WOS:000260097000007 PM 19160614 ER PT J AU Levsky, ME Young, SE Masullo, LN Miller, MA Herold, TJS AF Levsky, Marc E. Young, Scott E. Masullo, Lawrence N. Miller, Michael A. Herold, Thomas J. S. TI The Effects of an Accelerated Triage and Treatment Protocol on Left Without Being Seen Rates and Wait Times of Urgent Patients at a Military Emergency Department SO MILITARY MEDICINE LA English DT Article ID FAST-TRACK; RELIABILITY; VALIDITY; LEAVE; STAY AB To combat increasing wait times and left without being seen (LWOBS) rates, our emergency department (ED) implemented ail accelerated triage and treatment (TNT) protocol. A TNT team was allocated treatment rooms to begin management of urgent patients if a bed in the main ED was. not available. A retrospective database study was performed using three separate 6-month periods: two control periods before the intervention (P1, P2) and one period after the intervention (P3). The primary outcome measures were LWOBS rate, time to evaluation, and total ED time for urgent patients. The time to be seen for EC3 patients improved front P I to P3 by an average of 12.6 minutes (18.5%, p < 0.0001) and front P2 to P3 by an average of 12.0 minutes (17.6%, p < 0.0001). The EC3 LWOBS rate decreased front 2.0% in PI and 1.9% in P2 to 0.8% in P3 (1) < 0.0001 for both). The use of an accelerated TNT protocol was associated with a significant reduction in EC3 patient LWOBS rates and time to evaluation. C1 [Levsky, Marc E.; Masullo, Lawrence N.; Herold, Thomas J. S.] Carl R Darnall Army Med Ctr, Dept Emergency Med, Ft Hood, TX 76544 USA. [Young, Scott E.] Womack Army Med Ctr, Dept Emergency Med, Ft Bragg, NC 28310 USA. [Miller, Michael A.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. RP Levsky, ME (reprint author), Carl R Darnall Army Med Ctr, Dept Emergency Med, 36000 Darnall Loop, Ft Hood, TX 76544 USA. NR 13 TC 9 Z9 9 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2008 VL 173 IS 10 BP 999 EP 1003 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 360ZJ UT WOS:000260097000012 PM 19160619 ER PT J AU Keith, MP Roebuck, JD AF Keith, Michael P. Roebuck, Jonathan D. TI A 31-Year-Old Army Specialist Presenting with Acute Oligoarthritis SO MILITARY MEDICINE LA English DT Article ID ACUTE GOUTY-ARTHRITIS; URIC-ACID; SERUM URATE; HYPERURICEMIA; ATTACKS; LEVEL AB A 31-year-old Army specialist was evaluated at Walter Reed Army Medical Center for an acute attack of arthritis in the left hand. After an initial evaluation. the patient was referred to the rheumatology service, and gout was diagnosed on the basis of synovial fluid analysis. This case demonstrates an uncommon presentation of a common disorder in an active duty soldier. The discussions presented following the clinical data are meant to expand diagnostic considerations for patients with similar symptoms, to address risk factors for gout relevant to the military, and to clarify the management of gout. C1 [Keith, Michael P.] Natl Naval Med Ctr, Dept Rheumatol, Bethesda, MD 20889 USA. [Roebuck, Jonathan D.] Walter Reed Army Med Ctr, Div Rheumatol & Clin Immunol, Washington, DC 20307 USA. RP Keith, MP (reprint author), Natl Naval Med Ctr, Dept Rheumatol, Bethesda, MD 20889 USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 2008 VL 173 IS 10 BP 1044 EP 1047 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 360ZJ UT WOS:000260097000021 PM 19160628 ER PT J AU Mikolajczak, SA Silva-Rivera, H Peng, XX Tarun, AS Camargo, N Jacobs-Lorena, V Daly, TM Bergman, LW de la Vega, P Williams, J Aly, ASI Kappe, SHI AF Mikolajczak, Sebastian A. Silva-Rivera, Hilda Peng, Xinxia Tarun, Alice S. Camargo, Nelly Jacobs-Lorena, Vanessa Daly, Thomas M. Bergman, Lawrence W. de la Vega, Patricia Williams, Jack Aly, Ahmed S. I. Kappe, Stefan H. I. TI Distinct malaria parasite sporozoites reveal transcriptional changes that cause differential tissue infection competence in the mosquito vector and mammalian host SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID PLASMODIUM-YOELII; RODENT MALARIA; GLIDING MOTILITY; MULTIGENE FAMILY; SALIVARY-GLANDS; EXPRESSED GENES; LIVER INFECTION; PROTEIN; STAGE; MODEL AB The malaria parasite sporozoite transmission stage develops and differentiates within parasite oocysts on the Anopheles mosquito midgut. Successful inoculation of the parasite into a mammalian host is critically dependent on the sporozoite's ability to first infect the mosquito salivary glands. Remarkable changes in tissue infection competence are observed as the sporozoites transit from the midgut oocysts to the salivary glands. Our microarray analysis shows that compared to oocyst sporozoites, salivary gland sporozoites upregulate expression of at least 124 unique genes. Conversely, oocyst sporozoites show upregulation of at least 47 genes (upregulated in oocyst sporozoites [UOS genes]) before they infect the salivary glands. Targeted gene deletion of UOS3, encoding a putative transmembrane protein with a thrombospondin repeat that localizes to the sporozoite secretory organelles, rendered oocyst sporozoites unable to infect the mosquito salivary glands but maintained the parasites' liver infection competence. This phenotype demonstrates the significance of differential UOS expression. Thus, the UIS-UOS gene classification provides a framework to elucidate the infectivity and transmission success of Plasmodium sporozoites on a whole-genome scale. Genes identified herein might represent targets for vector-based transmission blocking strategies (UOS genes), as well as strategies that prevent mammalian host infection (UIS genes). C1 [Mikolajczak, Sebastian A.; Silva-Rivera, Hilda; Peng, Xinxia; Tarun, Alice S.; Camargo, Nelly; Jacobs-Lorena, Vanessa; Aly, Ahmed S. I.; Kappe, Stefan H. I.] Seattle Biomed Res Inst, Seattle, WA 98109 USA. [Daly, Thomas M.; Bergman, Lawrence W.] Drexel Univ, Coll Med, Dept Microbiol & Immunol, Div Mol Parasitol, Philadelphia, PA 19129 USA. [de la Vega, Patricia; Williams, Jack] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Kappe, Stefan H. I.] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA. RP Kappe, SHI (reprint author), Seattle Biomed Res Inst, 307 Westlake Ave N,Suite 500, Seattle, WA 98109 USA. EM stefan.kappe@sbri.org OI Tarun, Alice/0000-0002-0300-6657; Mikolajczak, Sebastian/0000-0003-1996-9703 FU National Institutes of Health; SBRI FX This work was funded by a grant from the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative and an SBRI institutional grant to S. H. I. K. Design and construction of the P. yoelii microarray were supported by the National Institutes of Health (to L.W.B.).; A potential conflict of interest is as follows: S.H.I.K. is an inventor listed on U.S. patent no. 7,22,179, U. S. patent no. 7,261,884, and international patent application PCT/US2004/043023, each titled "Live genetically attenuated malaria vaccine." NR 42 TC 42 Z9 43 U1 2 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD OCT PY 2008 VL 28 IS 20 BP 6196 EP 6207 DI 10.1128/MCB.00553-08 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 354JB UT WOS:000259634800005 PM 18710954 ER PT J AU Kulik, L Fleming, SD Moratz, C Quigg, RJ Silverman, GJ Tsokos, GC Holers, VM AF Kulik, Liudmila Fleming, Sherry D. Moratz, Chantal Quigg, Richard J. Silverman, Gregg J. Tsokos, George C. Holers, V. Michael TI Pathogenic natural antibodies recognizing Annexin IV are required to develop intestinal ischaemia-reperfusion injury and are selected during development in a CR2/CD21-dependent manner SO MOLECULAR IMMUNOLOGY LA English DT Meeting Abstract CT 22nd International Complement Workshop CY SEP 28-OCT 02, 2008 CL Basel, SWITZERLAND C1 [Kulik, Liudmila; Holers, V. Michael] Univ Colorado, Hlth Sci Ctr, Aurora, CO USA. [Fleming, Sherry D.] Kansas State Univ, Manhattan, KS 66506 USA. [Moratz, Chantal; Tsokos, George C.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Quigg, Richard J.] Univ Chicago, Chicago, IL 60637 USA. [Tsokos, George C.] Univ Calif San Diego, La Jolla, CA 92093 USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0161-5890 J9 MOL IMMUNOL JI Mol. Immunol. PD OCT PY 2008 VL 45 IS 16 SI SI MA 045 BP 4110 EP 4110 DI 10.1016/j.molimm.2008.08.046 PG 1 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA 363DB UT WOS:000260245000053 ER PT J AU Hartings, JA Gugliotta, M Gilman, C Strong, AJ Tortella, FC Bullock, MR AF Hartings, Jed A. Gugliotta, Marinella Gilman, Charlotte Strong, Anthony J. Tortella, Frank C. Bullock, M. Ross TI Repetitive cortical spreading depolarizations in a case of severe brain trauma SO NEUROLOGICAL RESEARCH LA English DT Article DE Spreading cortical depression; seizure; traumatic brain injury; microdialysis; electroencephalography; critical care ID FOCAL CEREBRAL-ISCHEMIA; POSITRON-EMISSION-TOMOGRAPHY; INJURED HUMAN BRAIN; SEVERE HEAD-INJURY; PERIINFARCT DEPOLARIZATIONS; ARTERY OCCLUSION; BLOOD-FLOW; RAT-BRAIN; MODERATE HYPOTHERMIA; REGIONAL CHANGES AB Objective and importance: Cortical spreading depolarizations (CSD) are waves of mass tissue depolarization that mediate progressive development of cortical infarction in animal models and occur in similar to 50% of patients with acute brain injury. Here we performed multi-modal cerebral monitoring to investigate pathologies associated with CSD occurrence in a case of severe traumatic brain injury. Clinical presentation: A 20 years old male suffering severe traumatic brain injury from a fall had extensive frontal subdural and intraparenchymal hemorrhage with mass effect. Craniectomy was performed for hematoma evacuation and decompression. Intervention: During surgery, a subdural electrocorticography (ECoG) electrode strip, along with microdialysis and PtiO2 probes, was placed beside injured cortex for CSD monitoring. Within 13-81 hours post-injury, 34 CSD occurred. CSD incidence increased during spontaneous hyperthermia and decreased during induced normothermia. Periods of CSD activity were also associated with low brain glucose (<0.10 mmol/l), elevated glutamate (>40 mmol/l) and lactate/pyruvate (>40), and PtiO2<10 mmHg. CSD caused progressive deterioration of ECoG activity only in regions with infarction at follow-up on day 27. Conclusion: Repetitive mass tissue depolarizations accompanied a negative course of hemorrhagic lesion progression in the presence of ischemic conditions after traumatic brain injury. Whether as cause or effect, CSD may represent an inherent component of progressive metabolic failure leading to tissue death, and temperature appears to be an important factor influencing their occurrence. Continuous ECoG is a valuable tool for monitoring subclinical events such as CSD and seizures and for translational research in acute brain injury mechanisms and therapeutics. [Neurol Res 2008; 30: 876-882] C1 [Hartings, Jed A.; Tortella, Frank C.] Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD 20910 USA. [Gugliotta, Marinella; Gilman, Charlotte; Bullock, M. Ross] Virginia Commonwealth Univ, Div Neurosurg, Richmond, VA USA. [Strong, Anthony J.] Kings Coll Hosp London, Dept Neurosurg, London, England. RP Hartings, JA (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jed.hartings@na.amedd.army.mil FU US Department of Defense FX This work was supported by US Department of Defense funding. The views of the authors do not purport or reflect the position of the Department of the Army or the Department of Defense (para 4-3, AR 360-5). NR 42 TC 15 Z9 15 U1 0 U2 2 PU MANEY PUBLISHING PI LEEDS PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND SN 0161-6412 J9 NEUROL RES JI Neurol. Res. PD OCT PY 2008 VL 30 IS 8 BP 876 EP 882 DI 10.1179/174313208X309739 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 358FG UT WOS:000259901900015 PM 18534057 ER PT J AU Campbell, WW Landau, ME AF Campbell, William W. Landau, Mark E. TI Controversial Entrapment Neuropathies SO NEUROSURGERY CLINICS OF NORTH AMERICA LA English DT Article DE Thoracic outlet syndrome; Radial tunnel syndrome; Arcade of Struthers; Piriformis syndrome; Tarsal tunnel syndrome ID THORACIC-OUTLET SYNDROME; RADIAL TUNNEL-SYNDROME; PIRIFORMIS-SYNDROME; TARSAL TUNNEL; ULNAR NERVE; SURGICAL DECOMPRESSION; DIABETIC-NEUROPATHY; BRACHIAL PLEXOPATHIES; INTRINSIC MUSCLES; PERIPHERAL-NERVES AB There is no significant disagreement about the major common entrapment neuropathies, such as carpal tunnel syndrome (CTS), ulnar neuropathy at the elbow, and peroneal neuropathy at the knee. In contrast, there is a group of entrapment syndromes about which there is major disagreement, including whether or not they even exist. There are other entrapment syndromes about which clinical questions arise on a regular basis, and which are the subject of this discussion. These include thoracic outlet syndrome, radial tunnel syndrome, ulnar nerve entrapment at the arcade of Struthers, piriformis syndrome, and tarsal tunnel syndrome. C1 [Landau, Mark E.] Walter Reed Army Med Ctr, Dept Neurol, Washington, DC 20307 USA. [Campbell, William W.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA. RP Landau, ME (reprint author), Walter Reed Army Med Ctr, Dept Neurol, 6900 Georgia Ave, Washington, DC 20307 USA. EM mark.landau@amedd.army.mil NR 81 TC 16 Z9 16 U1 0 U2 6 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1042-3680 J9 NEUROSURG CLIN N AM JI Neurosurg. Clin. N. Am. PD OCT PY 2008 VL 19 IS 4 BP 597 EP + DI 10.1016/j.nec.2008.07.001 PG 14 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA 387ZV UT WOS:000261991000009 PM 19010284 ER PT J AU Andersen, R Davis, S Scoville, C AF Andersen, Romney Davis, Shelton Scoville, Chuck TI Rehabilitation of Military Amputees: From Injury to Independence SO ORTHOPEDICS LA English DT Editorial Material C1 [Andersen, Romney] Natl Naval Med Ctr, Integrated Dept Orthoped & Rehabil, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Andersen, R (reprint author), Natl Naval Med Ctr, Integrated Dept Orthoped & Rehabil, Bethesda, MD USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD OCT PY 2008 VL 31 IS 10 BP 1000 EP 1002 PG 3 WC Orthopedics SC Orthopedics GA 359JW UT WOS:000259984000013 ER PT J AU Alldredge, ES Badescu, SC Bajwa, N Perkins, FK Snow, ES Reinecke, TL Passmore, JL Chang, YL AF Alldredge, E. S. Badescu, S. C. Bajwa, N. Perkins, F. K. Snow, E. S. Reinecke, T. L. Passmore, J. L. Chang, Y. L. TI Adsorption of linear chain molecules on carbon nanotubes SO PHYSICAL REVIEW B LA English DT Article ID AROMATIC ORGANIC-MOLECULES; NONCOVALENT FUNCTIONALIZATION; TRANSPORT-PROPERTIES; DENSITY FUNCTIONALS; CHEMICAL-DETECTION; DEFECTS; SENSORS AB We investigate molecular adsorption on single-walled carbon nanotubes (NTs) by ab initio calculations and by measurements of the conductivity response of NT arrays to trace vapors for a range of linear chain molecules. Experiment and calculations show that the short-time responses give adsorption energies that increase linearly with the molecular length. This systematic dependence indicates that the initial adsorption occurs on the defect-free regions of NTs and that these regions can play an important role in the adsorption process on NTs. C1 [Alldredge, E. S.; Badescu, S. C.; Bajwa, N.; Perkins, F. K.; Snow, E. S.; Reinecke, T. L.] USA, Res Lab, Washington, DC 20375 USA. [Passmore, J. L.; Chang, Y. L.] Nanomix Inc, Emeryville, CA 94608 USA. RP Badescu, SC (reprint author), USA, Res Lab, Washington, DC 20375 USA. EM stefan.badescu@nrl.navy.mil FU ONR; DTRA; NRC/NRL; ASEE/NRL FX This work was supported in part by ONR and DTRA. E. S. Alldredge is supported by NRC/NRL, and N. Bajwa is supported by ASEE/NRL. We acknowledge the support of the DoD High Performance Computing system for the calculations and also useful discussions with Victor Bermudez. NR 18 TC 12 Z9 12 U1 0 U2 12 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD OCT PY 2008 VL 78 IS 16 AR 161403 DI 10.1103/PhysRevB.78.161403 PG 4 WC Physics, Condensed Matter SC Physics GA 367TC UT WOS:000260574500015 ER PT J AU Nusinovich, GS Vlasov, AN Antonsen, TM Lohr, J Danly, BG Hogge, JP AF Nusinovich, G. S. Vlasov, A. N. Antonsen, T. M., Jr. Lohr, J. Danly, B. G. Hogge, J. -P. TI Excitation of parasitic modes in gyrotrons with fast voltage rise SO PHYSICS OF PLASMAS LA English DT Article ID STARTUP; GYRODEVICES; COMPETITION AB Megawatt-class, long-pulse and continuous-wave gyrotrons operate in high-order modes in order to handle the thermal losses in the resonators. The spectral density of neighboring modes in these devices is high; consequently during the beam voltage rise parasitic modes can be excited. If such gyrotrons are used in plasma experiments, these parasites can be dangerous for the receiving channels of numerous diagnostic tools. It is shown that in gyrotrons utilizing diode-type magnetron injection guns the shortening of the voltage rise time to about one microsecond can practically eliminate excitation of parasitic modes even in devices with a 2 MW power level. Some means for realizing such rise times in high-voltage modulators which can be used for megawatt-class gyrotrons are discussed. It is also shown that allowable beam voltage overshoot in such gyrotrons is about 2.5%. (C) 2008 American Institute of Physics. [DOI: 10.1063/1.2988336] C1 [Nusinovich, G. S.; Antonsen, T. M., Jr.] Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. [Vlasov, A. N.] Sci Applicat Int Corp, Mclean, VA 22102 USA. [Lohr, J.] Gen Atom Co, San Diego, CA 92186 USA. [Danly, B. G.] USA, Res Lab, Washington, DC 20375 USA. [Hogge, J. -P.] Ecole Polytech Fed Lausanne, EURATOM Assoc, Ctr Rech Phys Plasmas, SB, Lausanne, Switzerland. RP Nusinovich, GS (reprint author), Univ Maryland, Inst Res Elect & Appl Phys, College Pk, MD 20742 USA. RI Hogge, Jean-Philippe/D-4143-2014; Nusinovich, Gregory/C-1314-2017; Antonsen, Thomas/D-8791-2017 OI Nusinovich, Gregory/0000-0002-8641-5156; Antonsen, Thomas/0000-0002-2362-2430 FU Office of Fusion Energy of the U.S. Department of Energy FX The work is supported by the Office of Fusion Energy of the U. S. Department of Energy. NR 21 TC 8 Z9 8 U1 0 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1070-664X J9 PHYS PLASMAS JI Phys. Plasmas PD OCT PY 2008 VL 15 IS 10 AR 103101 DI 10.1063/1.2988336 PG 5 WC Physics, Fluids & Plasmas SC Physics GA 367SP UT WOS:000260573100043 ER PT J AU West, BJ Geneston, EL Grigolini, P AF West, Bruce J. Geneston, Elvis L. Grigolini, Paolo TI Maximizing information exchange between complex networks SO PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS LA English DT Review DE Complexity matching; Information propagation; Renewal; Ergodic; Non-ergodic; 1/f-noise; Global warming ID GENERALIZED LANGEVIN EQUATION; APERIODIC STOCHASTIC RESONANCE; CHAPMAN-KOLMOGOROV EQUATION; SELF-ORGANIZED CRITICALITY; RANGE FRACTAL CORRELATIONS; FOKKER-PLANCK EQUATIONS; ANOMALOUS DIFFUSION; 1/F NOISE; PHASE SYNCHRONIZATION; CORTICAL-NEURONS AB Science is not merely the smooth progressive interaction of hypothesis, experiment and theory, although it sometimes has that form. More realistically the scientific study of any given complex phenomenon generates a number of explanations, from a variety of perspectives, that eventually requires synthesis to achieve a deep level of insight and understanding. One such synthesis has created the field of out-of-equilibrium statistical physics as applied to the understanding of complex dynamic networks. Over the past forty years the concept of complexity has undergone a metamorphosis. Complexity was originally seen as a consequence of memory in individual particle trajectories, in full agreement with a Hamiltonian picture of microscopic dynamics and, in principle, macroscopic dynamics could be derived from the microscopic Hamiltonian picture. The main difficulty in deriving macroscopic dynamics from microscopic dynamics is the need to take into account the actions of a very large number of components. The existence of events such as abrupt jumps, considered by the conventional continuous time random walk approach to describing complexity was never perceived as conflicting with the Hamiltonian view. Herein we review many of the reasons why this traditional Hamiltonian view of complexity is unsatisfactory. We show that as a result of technological advances, which make the observation of single elementary events possible, the definition of complexity has shifted from the conventional memory concept towards the action of non-Poisson renewal events. We show that the observation of crucial processes, such as the intermittent fluorescence of blinking quantum dots as well as the brain's response to music, as monitored by a set of electrodes attached to the scalp, has forced investigators to go beyond the traditional concept of complexity and to establish closer contact with the nascent field of complex networks. Complex networks form one of the most challenging areas of modern research overarching all of the traditional scientific disciplines. The transportation networks of planes, highways and railroads; the economic networks of global finance and stock markets; the social networks of terrorism, governments, businesses and churches; the physical networks of telephones, the Internet, earthquakes and global warming and the biological networks of gene regulation, the human body, clusters of neurons and food webs, share a number of apparently universal properties as the networks become increasingly complex. Ubiquitous aspects of such complex networks are the appearance of non-stationary and non-ergodic statistical processes and inverse power-law statistical distributions. Herein we review the traditional dynamical and phase-space methods for modeling such networks as their complexity increases and focus on the limitations of these procedures in explaining complex networks. Of course we will not be able to review the entire nascent field of network science, so we limit ourselves to a review of how certain complexity barriers have been surmounted using newly applied theoretical concepts such as aging, renewal, non-ergodic statistics and the fractional calculus. One emphasis of this review is information transport between complex networks, which requires a fundamental change in perception that we express as a transition from the familiar stochastic resonance to the new concept of complexity matching. Published by Elsevier B.V. C1 [West, Bruce J.] Army Res Off, Res Triangle Pk, NC 27708 USA. [West, Bruce J.] Duke Univ, Dept Phys, Durham, NC 27709 USA. [Geneston, Elvis L.; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA. [Geneston, Elvis L.] La Sierra Univ, Dept Phys, Riverside, CA 92515 USA. [Grigolini, Paolo] Area Ric, CNR, Ist Proc Chim Fisici, I-56124 Pisa, Italy. [Grigolini, Paolo] Univ Pisa, Dipartimento Fis E Fermi, I-56127 Pisa, Italy. RP West, BJ (reprint author), Army Res Off, Res Triangle Pk, NC 27708 USA. EM bwest@nc.rr.com RI West, Bruce/E-3944-2017 FU ARO; Welch [W911NF-05-1-0205, B-1577] FX The authors acknowledge financial support from ARO and E.G. and P.G. additional support from Welch through grants W911NF-05-1-0205 and B-1577, respectively. NR 388 TC 98 Z9 103 U1 10 U2 86 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0370-1573 EI 1873-6270 J9 PHYS REP JI Phys. Rep.-Rev. Sec. Phys. Lett. PD OCT PY 2008 VL 468 IS 1-3 BP 1 EP 99 DI 10.1016/j.physrep.2008.06.003 PG 99 WC Physics, Multidisciplinary SC Physics GA 374MV UT WOS:000261048600001 ER PT J AU Scafetta, N West, BJ AF Scafetta, Nicola West, Bruce J. TI Is Climate Sensitive to Solar Variability? SO PHYSICS TODAY LA English DT Letter ID NORTHERN-HEMISPHERE TEMPERATURES C1 [Scafetta, Nicola] Duke Univ, Durham, NC 27710 USA. [West, Bruce J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Scafetta, N (reprint author), Duke Univ, Durham, NC 27710 USA. EM ns2002@duke.edu; bruce.j.west@us.army.mil OI Scafetta, Nicola/0000-0003-0967-1911 NR 5 TC 0 Z9 0 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD OCT PY 2008 VL 61 IS 10 BP 14 EP + PG 2 WC Physics, Multidisciplinary SC Physics GA 357VP UT WOS:000259875600009 ER PT J AU Grujicic, M Arakere, G He, T Gogulapati, M Cheeseman, BA AF Grujicic, M. Arakere, G. He, T. Gogulapati, M. Cheeseman, B. A. TI A numerical investigation of the influence of yarn-level finite-element model on energy absorption by a flexible-fabric armour during ballistic impact SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS LA English DT Article DE flexible armour; high-performance fibres; ballistic performance ID PLAIN-WEAVE FABRICS; DEFORMATION THEORY; WOVEN FABRICS; FRICTION; SIMULATION; BEHAVIOR AB A series of transient non-linear dynamic finite-element method (FEM) analyses pertaining to the interaction of a single-ply plain-woven balanced square textile-fabric armour with a spherical steel projectile is carried out in order to compare the corresponding results obtained for two different yarn models: (a) a solid FEM model in which the warp and weft yarns are represented using first-order three-dimensional solid elements and (b) a membrane model in which the same yarns are represented using second-order membrane elements. The analyses are carried out under different yarn-yarn and projectile-fabric frictional conditions and under different far-field boundary conditions applied to the edges of the fabric. The results obtained showed that the two sets of analyses yield comparable predictions regarding the temporal evolution and the spatial distribution of the deformation and damage fields within the fabric, regarding the ability of the fabric to absorb the projectile's kinetic energy and regarding the relative contributions of the main energy absorbing mechanisms. The work also confirmed the roles yarn-yarn and projectile-fabric friction play in the impact process as well as the effect of the far-field boundary conditions applied to the edges of the fabric. C1 [Grujicic, M.; Arakere, G.; He, T.; Gogulapati, M.] Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.] Army Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, Int Ctr Automot Res CU ICAR, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica@ces.clemson.edu FU US Army/Clemson University [W911NF-04-2-0024, W911NF-06-2-0042] FX This work was supported by the US Army/Clemson University Cooperative Agreements W911NF-04-2-0024 and W911NF-06-2-0042. The authors are indebted to Dr Fred Stanton for the support and a continuing interest in this work. NR 25 TC 20 Z9 20 U1 0 U2 10 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 1464-4207 J9 P I MECH ENG L-J MAT JI Proc. Inst. Mech. Eng. Pt. L-J. Mater.-Design Appl. PD OCT PY 2008 VL 222 IS L4 BP 259 EP 276 DI 10.1243/14644207JMDA209 PG 18 WC Materials Science, Multidisciplinary SC Materials Science GA 379ZK UT WOS:000261435100005 ER PT J AU Ciezak, JA Jenkins, TA AF Ciezak, Jennifer A. Jenkins, Timothy A. TI The Low-Temperature High-Pressure Phase Diagram of Energetic Materials: I. Hexahydro-1,3,5-Trinitro-s-Triazine SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article DE Diamond Anvil Cell; Hexahydro-1,3,5-Trinitro-s-Triazine; High Pressure; RDX; Vibrational Spectroscopy ID VIBRATIONAL SPECTROSCOPY; RDX AB The reaction phase diagram of hexahydro-1,3,5-trinitro-s-triazine (RDX) has been studied as a function of temperature and pressure by Raman spectroscopy to 29 GPa and temperatures ranging from 4 to 298 K. Three stable phases (alpha, gamma, and delta) have been found and their phase stabilities have been investigated. Phase boundaries were studied as a function of pressure and temperature, permitting a delineation of the various polymorph stability fields. A pressure-temperature reaction/phase diagram is constructed from the results of this study and compared to previous high temperature work. C1 [Ciezak, Jennifer A.] USA, Res Lab, BWCD PSB WMRD, Aberdeen Proving Ground, MD 21005 USA. [Ciezak, Jennifer A.; Jenkins, Timothy A.] Carnegie Inst Washington, Geophys Lab, Washington, DC 20015 USA. RP Ciezak, JA (reprint author), USA, Res Lab, BWCD PSB WMRD, Aberdeen Proving Ground, MD 21005 USA. EM jciezak@arl.army.mil NR 16 TC 20 Z9 21 U1 0 U2 7 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD OCT PY 2008 VL 33 IS 5 BP 390 EP 395 DI 10.1002/prep.200700258 PG 6 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA 369TT UT WOS:000260717500009 ER PT J AU Soares, JW Kirby, R Morin, KM Mello, CM AF Soares, Jason W. Kirby, Romy Morin, Kimberly M. Mello, Charlene M. TI Antimicrobial Peptide Preferential Binding of E. coli O157:H7 SO PROTEIN AND PEPTIDE LETTERS LA English DT Article DE Antimicrobial peptide; E. coli O157:H7; preferential binding; molecular recognition; whole cell binding; surface plasmon resonance ID CORONAVIRUS MAIN PROTEINASE; GRAM-NEGATIVE BACTERIA; ANTIBACTERIAL PEPTIDES; CELL SELECTIVITY; LYTIC PEPTIDES; CECROPIN P1; MECHANISM; MEMBRANE; MICROORGANISMS; CATHELICIDINS AB The studies presented here explore antimicrobial peptide preferential binding behavior for a target pathogen, Escherichia coli O157:H7. A modified immunoassay and surface plasmon resonance were employed to evaluate immobilized peptide binding of whole bacterial cells. The knowledge gained may guide the rational design of peptides with enhanced species binding selectivity. C1 [Soares, Jason W.; Kirby, Romy; Morin, Kimberly M.; Mello, Charlene M.] USA, Natick Soldier Res Dev & Engn Ctr, Biosci & Technol Team, Natick, MA 01760 USA. RP Mello, CM (reprint author), USA, Natick Soldier Res Dev & Engn Ctr, Biosci & Technol Team, Natick, MA 01760 USA. EM charlene.mello@us.army.mil FU U. S. Army Natick Soldier Research, Development and Engineering Center [PAO #08-92] FX Authors acknowledge Steve Arcidiacono and Andre Senecal for their continued assistance in research direction. We also thank Andrew Magyar from the Massachusetts Institute of Technology for assistance with zeta potential measurements. This manuscript has been approved for unlimited distribution by the U. S. Army Natick Soldier Research, Development and Engineering Center (PAO #08-92). NR 45 TC 14 Z9 14 U1 2 U2 10 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 0929-8665 J9 PROTEIN PEPTIDE LETT JI Protein Pept. Lett. PD OCT PY 2008 VL 15 IS 10 BP 1086 EP 1093 DI 10.2174/092986608786071049 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 360LD UT WOS:000260058100009 PM 19075820 ER PT J AU Saxena, A Luo, CY Doctor, BP AF Saxena, Ashima Luo, Chunyuan Doctor, Bhupendra P. TI Developing procedures for the large-scale purification of human serum butyrylcholinesterase SO PROTEIN EXPRESSION AND PURIFICATION LA English DT Article DE butyrylcholinesterase; human plasma; Cohn Fraction IV-4; purification; specific activity ID HALF-LIFE; PLASMA CHOLINESTERASE; COCAINE TOXICITY; SOMAN; ACETYLCHOLINESTERASE; PROTECTION; MICE; PRETREATMENT; METABOLISM; ANTIDOTE AB Human serum butyrylcholinesterase (Hu BChE) is the most viable candidate for the prophylactic treatment of organophosphate poisoning. A dose of 200 mg/70 kg is predicted to protect humans against 2 x LD50 of soman. Therefore, the aim of this study was to develop procedures for the purification of gram quantities of this enzyme from outdated human plasma or Cohn Fraction IV-4. The purification of Hu BChE was accomplished by batch adsorption on procainamide-Sepharose-CL-4B affinity gel followed by ion-exchange chromatography on a DEAE-Sepharose column. For the purification of enzyme from Cohn Fraction IV-4, it was resuspended in 25 mM sodium phosphate buffer, pH 8.0, and fat was removed by decantation, prior to batch adsorption on procainamide-Sepharose gel. In both cases, the procainamide gel was thoroughly washed with 25 mM sodium phosphate buffer, pH 8.0, containing 0.05 M NaCl, and the enzyme was eluted with the same buffer containing 0.1 M procainamide. The enzyme was dialyzed and the pH was adjusted to 4.0 before loading on the DEAE column equilibrated in sodium acetate buffer, pH 4.0. The column was thoroughly washed with 25 mM sodium phosphate buffer, pH 8.0 containing 0.05 M NaCl before elution with a gradient of 0.05-0.2 M NaCl in the same buffer. The purity of the enzyme following these steps ranged from 20% to 40%. The purity of the enzyme increased to > 90% by chromatography on an analytical procainamide affinity column. Results show that Cohn Fraction IV-4 is a much better source than plasma for the large-scale isolation of purified Hu BChE. Published by Elsevier Inc. C1 [Saxena, Ashima; Luo, Chunyuan; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil NR 33 TC 14 Z9 15 U1 0 U2 7 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1046-5928 EI 1096-0279 J9 PROTEIN EXPRES PURIF JI Protein Expr. Purif. PD OCT PY 2008 VL 61 IS 2 BP 191 EP 196 DI 10.1016/j.pep.2008.05.021 PG 6 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology GA 347WM UT WOS:000259172100014 PM 18602477 ER PT J AU Schmid, K Keasey, SL Pittman, P Emerson, GL Meegan, J Tikhonov, AP Chen, GX Schweitzer, B Ulrich, RG AF Schmid, Kara Keasey, Sarah L. Pittman, Phillip Emerson, Ginny L. Meegan, James Tikhonov, Alexander P. Chen, Gengxin Schweitzer, Barry Ulrich, Robert G. TI Analysis of the human immune response to vaccinia by use of a novel protein microarray suggests that antibodies recognize less than 10% of the total viral proteome SO PROTEOMICS CLINICAL APPLICATIONS LA English DT Article DE Antibody; Biomarker; Protein microarray; Vaccine; Vaccinia virus ID SMALLPOX VACCINATION; VIRUS; CELLS; GENES; EXPRESSION; ANTIGENS; ANKARA; MICE AB Control of smallpox by mass vaccination was one of the most effective public health measures ever employed for eradicating a devastating infectious disease. However, new methods are needed for monitoring smallpox immunity within current vulnerable populations, and for the development of replacement vaccines for use by immunocompromized or low-responding individuals. As a measure for achieving this goal, we developed a protein microarray of the vaccinia virus proteome by using high-throughput baculovirus expression and purification of individual elements. The array was validated with therapeutic-grade, human hyperimmune sera, and these data were compared to results obtained from individuals vaccinated against smallpox using Dryvax. A high level of reproducibility with a very low background were apparent in repetitive assays that confirmed previously reported antigens and identified new proteins that may be important for neutralizing viral infection. Our results suggest that proteins recognized by antibodies from all vaccinees constituted <10% of the total vaccinia proteome. C1 [Schmid, Kara; Keasey, Sarah L.; Ulrich, Robert G.] USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD 21702 USA. [Pittman, Phillip] USA, Med Res Inst Infect Dis, Mil Vaccine Clin Res Ctr, Frederick, MD 21702 USA. [Emerson, Ginny L.] Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA USA. [Meegan, James] Invitrogen Fed Syst, Frederick, MD USA. [Tikhonov, Alexander P.; Chen, Gengxin; Schweitzer, Barry] Invitrogen Corp, Branford, CT USA. RP Ulrich, RG (reprint author), USA, Med Res Inst Infect Dis, Lab Mol Immunol, 1425 Porter St, Frederick, MD 21702 USA. EM ulrich@ncifcrf.gov RI Tikhonov, Alexander/I-1453-2012 OI Tikhonov, Alexander/0000-0003-3808-9701 FU Joint Science and Technology Office [4.10017, W81XWH-05-2-0077] FX The authors acknowledge Peter Silvera (Southern Research Institute) for vaccinia neutralization assays, Shannon Beatty (Invitrogen Federal Systems) and Beverly Dyas (USA-MRIID), for technical contributions. The views, opinions, and/or findings contained in the present article are those of the authors and should not be construed as an official U.S. Government position, policy, or decision unless so designated by other documentation. Funded by Joint Science and Technology Office contracts 4.10017 (R. G. U.) and W81XWH-05-2-0077 (J. M.). James Meegan, Alexander P. Tikhonov, Gengxin Chen, and Barry Schweitzer are employed by Invitrogen, a for-profit organization. NR 32 TC 13 Z9 14 U1 0 U2 2 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1862-8346 J9 PROTEOM CLIN APPL JI Proteom. Clin. Appl. PD OCT PY 2008 VL 2 IS 10-11 BP 1528 EP 1538 DI 10.1002/prca.200780113 PG 11 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 362PG UT WOS:000260209000015 PM 21136800 ER PT J AU Senecal, A Magnone, J Marek, P Senecal, K AF Senecal, Andre Magnone, Joshua Marek, Patrick Senecal, Kris TI Development of functional nanofibrous membrane assemblies towards biological sensing SO REACTIVE & FUNCTIONAL POLYMERS LA English DT Article DE Electrospinning; Antibodies; Avidin; SEB toxin ID ELECTROSPUN NANOFIBERS; FIBERS AB A novel research approach was investigated that has the potential to improve sample preparation for complex matrices. Generation of high surface area nanofibrous membranes with covalently attached molecular recognition elements for selective capture of target biological agents were developed using the electrospinning fabrication technique. Two types of electrospun capture membranes were fabricated containing either carboxyl (COOH) or amine (NH2) functional groups for covalent attachment of antibodies. The carboxyl functional membrane was produced by electrospinning polyvinyl chloride (PVC) formulated to be 1.8% carboxylated. The amine functional membrane was made by coelectrospinning two polymers, water-soluble polyamine and water insoluble polyurethane. Linking of molecular recognition groups, antibodies, to the carboxylated PVC was performed using established crosslinking chemistries. Antigen/antibody experiments were tested on the electrospun membranes. Results showed that electrospun membranes, treated with a secondary antibody used as the analyte, reacted only with its complement as indicated with a chemiluminescent signal. Toxin studies with Staphylococcal enterotoxin B (SEB) were conducted using avidin/biotin chemistries on the electrospun membranes. Experiments were performed using a modified ELISA sandwich assay on the fibrous membranes in the following configuration: avidin-biotinylated SEB antibody-SEB toxin-SEB antibody-HRP. Results have shown that 1-100ng/ml concentrations of toxin were detected using a chemiluminescent signal detection scheme. Published by Elsevier Ltd. C1 [Senecal, Kris] USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. [Senecal, Andre; Magnone, Joshua; Marek, Patrick] USA, Performance Enhancement & Food Safety Team, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. RP Senecal, K (reprint author), USA, Mol Sci & Engn Team, Natick Soldier Res Dev & Engn Command, Natick, MA 01760 USA. EM kris.senecal@us.army.mil RI Senecal, Andre/E-6605-2010; Senecal, Kris/F-3000-2013 NR 15 TC 13 Z9 13 U1 2 U2 22 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1381-5148 J9 REACT FUNCT POLYM JI React. Funct. Polym. PD OCT PY 2008 VL 68 IS 10 BP 1429 EP 1434 DI 10.1016/j.reactfunctpolym.2008.06.022 PG 6 WC Chemistry, Applied; Engineering, Chemical; Polymer Science SC Chemistry; Engineering; Polymer Science GA 363KI UT WOS:000260265800003 ER PT J AU Martin, M Kecskes, L Thadhani, NN AF Martin, M. Kecskes, L. Thadhani, N. N. TI Dynamic compression of a zirconium-based bulk metallic glass confined by a stainless steel sleeve SO SCRIPTA MATERIALIA LA English DT Article DE bulk metallic glass; Taylor test; fracture; constitutive model ID CONSTITUTIVE MODEL VALIDATION; STRAIN-RATE; INDUCED EMBRITTLEMENT; MECHANICAL-BEHAVIOR; WIDE-RANGE; BE ALLOY; FRACTURE; DEFORMATION; COMPOSITES; FLOW AB Anvil-on-rod impact experiments were performed on zirconium-based bulk metallic glass rods with stainless steel confinement sleeves. High-speed photography and velocity interferometry were used to obtain qualitative and quantitative information about the transient deformation and failure response of the impacted specimens. Fracture surfaces of the recovered, impacted specimens were analyzed using scanning electron microscopy. Numerical simulations were also used to elucidate the deformation and failure response and better understand the effects of the altered stress states caused by the confinement sleeve. (C) 2008 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. C1 [Martin, M.; Thadhani, N. N.] Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. [Kecskes, L.] USA, Res Lab, Weap & Mat Res Directorate, AMSRD ARL WM MB, Aberdeen Proving Ground, MD 21005 USA. RP Thadhani, NN (reprint author), Georgia Inst Technol, Sch Mat Sci & Engn, 771 Ferst Dr NW, Atlanta, GA 30332 USA. EM thadhani@mse.gatech.edu RI Trexler, Morgana/E-9003-2013; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 FU ARO [E-48148-MS-000-05123-1] FX The authors gratefully acknowledge Liquidmetal Technologies for providing the specimens. This work was funded by ARO Grant No. E-48148-MS-000-05123-1 (Dr. Mullins, program monitor). M.M. is a recipient of a NASA Jenkins Fellowship. NR 36 TC 16 Z9 17 U1 5 U2 19 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1359-6462 J9 SCRIPTA MATER JI Scr. Mater. PD OCT PY 2008 VL 59 IS 7 BP 688 EP 691 DI 10.1016/j.scriptamat.2008.05.045 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 345AL UT WOS:000258968300004 ER PT J AU Atkins, JL Hammamieh, R Jett, M Gorbunov, NV Asher, LV Kiang, JG AF Atkins, James L. Hammamieh, Rasha Jett, Marti Gorbunov, Nikolai V. Asher, Ludmila V. Kiang, Juliann G. TI alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat SO SHOCK LA English DT Article DE alpha-defensin 4; ADMA; Reg 2; hemorrhage; Paneth cell ID NITRIC-OXIDE SYNTHASE; SYMMETRIC DIMETHYLARGININE; INFLAMMATORY RESPONSE; ENDOGENOUS INHIBITOR; PANETH CELLS; SHOCK; GUT; EXPRESSION; HYPOTHESIS; ADMA AB Mesenteric lymph contains unidentified proinflammatory mediators that increase in concentration after hemorrhage. In the search for candidate mediators, we examined mesenteric lymph for the presence of proinflammatory substances that are known to be produced in the gut: (a) antimicrobial peptides and antimicrobial proteins produced in the Paneth cells of the intestine (alpha-defensin 4, secretory phospholipase A2 [sPLA2], and Reg 2 protein) and (b) asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NOS. Anesthetized male rats were hemorrhaged to 40 mmHg and maintained at that pressure by intermittent blood withdrawal until the pressure fell to less than 40 mmHg (decompensation) at which point they were resuscitated with three times the shed blood volume of Ringer's lactate solution administered over 1 h. Mesenteric lymph samples were analyzed for ADMA by enzyme-linked immunosorbent assay and for alpha-defensin 4, sPLA2, and Reg2 by Western blotting. Protein concentration in lymph was unchanged by hemorrhage, but alpha-defensin 4 increased significantly (12-fold greater than control) as did ADMA (2-fold greater than control). The sPLA2 could not be detected in lymph, and Reg 2 was unchanged during hemorrhage. During resuscitation, lymph flow tended to increase, but the concentration of ADMA and alpha-defensin 4 by volume did not increase. Reg 2 decreased during resuscitation. The results indicate that ADMA and immunoreactive product to alpha-defensin 4 may contribute to the increase in inflammatory activity of mesenteric lymph during hemorrhage, but they are unlikely to be the mediators responsible for the increase in the concentration of inflammatory mediators in post resuscitation lymph. C1 [Atkins, James L.] Walter Reed Army Inst Res, Div Mil Casualty Res, Silver Spring, MD 20910 USA. [Gorbunov, Nikolai V.; Kiang, Juliann G.] Uniformed Serv Univ Hlth Sci, Armed Forces Radiobiol Res Inst, Bethesda, MD USA. RP Atkins, JL (reprint author), Walter Reed Army Inst Res, Div Mil Casualty Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM James.Atkins@na.amedd.army.mil RI Atkins, James/B-3577-2011 FU Department of the Army Peer Reviewed Medical Research Program [PR033201]; US Army Medical Research and Materiel Command; AFRRI Intramural Program [RAB2CF] FX This study was supported by the Department of the Army Peer Reviewed Medical Research Program (grant no. PR033201 to J.L.A.), by the US Army Medical Research and Materiel Command, and by the AFRRI Intramural Program (grant no. RAB2CF to J.G.K.). NR 37 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD OCT PY 2008 VL 30 IS 4 BP 411 EP 416 DI 10.1097/SHK.0b013e31816a71cb PG 6 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 351JK UT WOS:000259420400011 PM 18391861 ER PT J AU Pusey, HC Steinwolf, A AF Pusey, Henry C. Steinwolf, Alexander TI Acquiring and Analyzing Pyrotechnic Test Data - The Right Way! SO SOUND AND VIBRATION LA English DT Editorial Material C1 [Pusey, Henry C.] SAVIAC, Winchester, VA USA. [Pusey, Henry C.] USA, R&D Labs, Ft Belvoir, VA USA. RP Pusey, HC (reprint author), SAVIAC, Winchester, VA USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU ACOUSTICAL PUBL INC PI BAY VILLAGE PA 27101 E OVIATT RD, PO BOX 40416, BAY VILLAGE, OH 44140 USA SN 1541-0161 J9 SOUND VIB JI Sound Vib. PD OCT PY 2008 VL 42 IS 10 BP 8 EP 10 PG 3 WC Acoustics; Engineering, Mechanical; Mechanics SC Acoustics; Engineering; Mechanics GA 365TA UT WOS:000260429500002 ER PT J AU Carpenter, LT Pezeshki, SR Shields, FD AF Carpenter, L. T. Pezeshki, S. R. Shields, F. D., Jr. TI Responses of nonstructural carbohydrates to shoot removal and soil moisture treatments in Salix nigra SO TREES-STRUCTURE AND FUNCTION LA English DT Article DE Salix nigra; nonstructural carbohydrates; flooding; drought; shoot removal ID HYBRID POPLAR; GROWTH; WILLOW; SURVIVAL; CUTTINGS; ROOT; RESERVES; RESTORATION; ALLOCATION; HERBIVORY AB Aboveground disturbances are common in dynamic riparian environments, and Salix nigra is well adapted with a vigorous resprouting response. Soil moisture stresses are also common, and S. nigra is flood tolerant and drought sensitive. The objective of this study was to quantify nonstructural carbohydrate (NSC) reserves in S. nigra following shoot removal and soil moisture treatments. NSC reserves provide energy for regeneration of shoot tissue until new functional leaves are developed. Three soil moisture treatments: well-watered (W), periodic flooding (F) and drought (D); and three shoot removal treatments: no shoots removed (R0), partial shoot removal (R1), and complete shoot removal (R2) were applied. Plants were harvested when new shoot development was observed (day 13). Statistical significance in the 3 x 3-factorial design was determined in two-factor ANOVA at P < 0.05. Both roots and cuttings were important reservoirs for NSC during resprouting response, with decreases in root (31%) and cutting (14%) biomass in R2 compared to R0. Rapid recovery of photosynthetic surface area (from 15 to 37% of R0) was found in R1. A clear pattern of starch mobilization was found in roots in R0, R1 and R2, with lowest root starch concentration in W, F higher than W, and D higher than F. Shoot starch concentration was lower in F and D compared to W in R0, however, in R1 shoot starch was reduced in W compared to F and D, possibly indicating reduced rates of translocation during soil moisture stress. Evidence of osmotic adjustment was found in roots and shoots with higher total ethanol-soluble carbohydrates (TESC) during soil moisture stress in F and D treatments. Total plant NSC pool was greater in F and D treatments compared to W, and progressively reduced from R0 to R1 to R2. Results indicated negative effects of drought, and to a lesser extent periodic flooding on resprouting response in S. nigra, with implications for reduced survival when exposed to combined stresses of aboveground disturbance and soil moisture. C1 [Carpenter, L. T.] USACE, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. [Carpenter, L. T.; Pezeshki, S. R.] Univ Memphis, Dept Biol, Memphis, TN 38152 USA. [Shields, F. D., Jr.] Natl Sedimentat Lab, USDA ARS, Oxford, MS 38655 USA. RP Carpenter, LT (reprint author), USACE, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM Lili.Carpenter@usace.army.mil; pezeshki@memphis.edu; dshields@ars.usda.gov FU Tennessee Federation of Garden Clubs; U. S. Department of Agriculture, National Sedimentation Laboratory FX Partial funding for this project was provided by The Tennessee Federation of Garden Clubs and U. S. Department of Agriculture, National Sedimentation Laboratory. We thank: Heidi Bissell and the Memphis Zoo for training in carbohydrates analyses; Silpa Pallopathu, Brian Knight, Brandi Johnson and Lyndsay Saunders for contributing over 100 h each to data collection; Steve Kynerd for assistance with experimental set up; Dr. Corinna Ethington for statistical support; and Don Baud, Raquel Marion, Sam Pierce, Dr. Scott Franklin and Margaret Cirtain for their valuable help during the project. NR 43 TC 19 Z9 24 U1 3 U2 25 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0931-1890 J9 TREES-STRUCT FUNCT JI Trees-Struct. Funct. PD OCT PY 2008 VL 22 IS 5 BP 737 EP 748 DI 10.1007/s00468-008-0234-7 PG 12 WC Forestry SC Forestry GA 349DL UT WOS:000259258900014 ER PT J AU DuVernoy, TS Mitchell, KC Myers, RA Walinski, LW Tinsley, MO AF DuVernoy, T. S. Mitchell, K. C. Myers, R. A. Walinski, L. W. Tinsley, M. O. TI The first laboratory-confirmed rabid pig in Maryland, 2003 SO ZOONOSES AND PUBLIC HEALTH LA English DT Article DE rabies; pig; swine ID PUBLIC VETERINARY-MEDICINE; UNITED-STATES; SURVEILLANCE; HEALTH; SWINE AB This article is the first to describe the clinical picture and potential human health impact of laboratory-confirmed rabies infection in a pet Vietnamese pot-bellied pig in Maryland. Although cases of confirmed rabies infection have been infrequently reported in pet or agricultural during the past 10 years in the United States, exposure to rabies-positive animals remains a public health concern particularly for veterinarians, pet owners and other animal caretakers. It is important that individuals who are in a high-risk rabies exposure group remain vigilant to this potential public health threat in all mammal species. C1 [DuVernoy, T. S.] Walter Reed Army Inst Res, Div Prevent Med, Dept Def Global Emerging Infect Surveillance & Re, Silver Spring, MD 20910 USA. [Mitchell, K. C.] Maryland Dept Hlth & Mental Hyg, Ctr Vet Publ Hlth, Div Rabies & Vector Borne Dis, Baltimore, MD USA. [Myers, R. A.] Maryland Dept Hlth & Mental Hyg, Labs Adm, Baltimore, MD USA. [Walinski, L. W.] Maryland Dept Hlth & Mental Hyg, Bur Environm Hlth, Harford Cty Hlth Dept, Bel Air, MD USA. [Tinsley, M. O.] Maryland Dept Hlth & Mental Hyg, Harford Cty Hlth Dept, Food Control Div, Bel Air, MD USA. RP DuVernoy, TS (reprint author), Walter Reed Army Inst Res, Div Prevent Med, Dept Def Global Emerging Infect Surveillance & Re, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM tracy.duvernoy@us.army.mil NR 18 TC 3 Z9 4 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1863-1959 J9 ZOONOSES PUBLIC HLTH JI Zoonoses Public Health PD OCT PY 2008 VL 55 IS 8-10 BP 431 EP 435 DI 10.1111/j.1863-2378.2008.01159.x PG 5 WC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences SC Public, Environmental & Occupational Health; Infectious Diseases; Veterinary Sciences GA 347OA UT WOS:000259149700009 PM 18811906 ER PT J AU Reed, ML Readinger, ED Shen, H Wraback, M Syrkin, A Usikov, A Kovalenkov, OV Dmitriev, VA AF Reed, M. L. Readinger, E. D. Shen, H. Wraback, M. Syrkin, A. Usikov, A. Kovalenkov, O. V. Dmitriev, V. A. TI n-InGaN/p-GaN single heterostructure light emitting diode with p-side down SO APPLIED PHYSICS LETTERS LA English DT Article ID MULTIPLE-QUANTUM WELLS; EPITAXY AB The effects of negative polarization charge at the n-InGaN/p-GaN interface on the performance of hydride vapor phase-epitaxy deposited single heterostructure n-InGaN/p-GaN LEDs with p-side down are investigated. The strong peak emission wavelength blueshift and concomitant superlinear increase in light output as the injection current increases below 25 A/cm(2) are characteristic of radiative tunneling. We show that the combination of two-dimensional hole gas formation on the n-InGaN side of the heterointerface and enhancement of the electron barrier to transport across this interface results in only similar to 10% efficiency droop up to 500 A/cm(2) without implementation of an AlGaN electron-blocking layer or a second heterointerface. (C) 2008 American Institute of Physics. C1 [Reed, M. L.; Readinger, E. D.; Shen, H.; Wraback, M.] USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, Adelphi, MD 20783 USA. [Syrkin, A.; Usikov, A.; Kovalenkov, O. V.; Dmitriev, V. A.] Technol & Devices Int Inc, Silver Spring, MD 20904 USA. RP Reed, ML (reprint author), USA, Res Lab, Sensors & Electron Devices Directorate, AMSRD ARL SE EM, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM meredith.l.reed@us.army.mil FU U. S. Department of Energy Solid State Lighting Program FX TDI, Inc. gratefully acknowledges the support of the U. S. Department of Energy Solid State Lighting Program. NR 16 TC 17 Z9 17 U1 1 U2 13 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 29 PY 2008 VL 93 IS 13 AR 133505 DI 10.1063/1.2992582 PG 3 WC Physics, Applied SC Physics GA 356RA UT WOS:000259794100110 ER PT J AU Lukashevich, IS Carrion, R Salvato, MS Mansfield, K Brasky, K Zapata, J Cairo, C Goicochea, M Hoosien, GE Ticer, A Bryant, J Davis, H Hammamieh, R Mayda, M Jett, M Patterson, J AF Lukashevich, Igor S. Carrion, Ricardo, Jr. Salvato, Maria S. Mansfield, Keith Brasky, Kathleen Zapata, Juan Cairo, Cristiana Goicochea, Marco Hoosien, Gia E. Ticer, Anysha Bryant, Joseph Davis, Harry Hammamieh, Rasha Mayda, Maria Jett, Marti Patterson, Jean TI Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates SO VACCINE LA English DT Article DE Arenaviruses; Lassa fever; Vaccine; Protection ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NUCLEOTIDE-SEQUENCE; LIVER PATHOLOGY; NIGERIAN STRAIN; RHESUS MACAQUES; MOPEIA VIRUSES; GUINEA-PIGS; INFECTION; GENE; RNA AB A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Lukashevich, Igor S.; Salvato, Maria S.; Zapata, Juan; Cairo, Cristiana; Goicochea, Marco; Bryant, Joseph; Davis, Harry] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA. [Carrion, Ricardo, Jr.; Brasky, Kathleen; Hoosien, Gia E.; Ticer, Anysha; Patterson, Jean] SW Fdn Biomed Res, San Antonio, TX 78284 USA. [Mansfield, Keith] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Southborough, MA 01772 USA. [Hammamieh, Rasha; Mayda, Maria; Jett, Marti] Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD USA. RP Lukashevich, IS (reprint author), Univ Maryland, Sch Med, Inst Human Virol, 725 W Lombard St, Baltimore, MD 21201 USA. EM ilukashevich@ihv.umaryland.edu FU National Institutes of Health [RO1 AI052367]; Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases Researches; MARCE [U54 AI057168]; WRCE [U54 AI057156]; NIH [AI053620]; New England Primate Center [P51 RR00168-45] FX This work was supported by grant RO1 AI052367 (to I.S.L.) from the National Institutes of Health and by the Regional Centers of Excellence in Biodefense and Emerging Infectious Diseases Researches, MARCE (U54 AI057168, subcontract to I.S.L.) and WRCE (U54 AI057156, subcontract to J.L.P.). Funding for microarray studies was from NIH grant AI053620 (to M.S.S.). We acknowledge the New England Primate Center (grant P51 RR00168-45) for histological support. NR 39 TC 42 Z9 42 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 26 PY 2008 VL 26 IS 41 BP 5246 EP 5254 DI 10.1016/j.vaccine.2008.07.057 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 361TB UT WOS:000260148900005 PM 18692539 ER PT J AU Doctor, BP Tsim, KWK Siow, NL AF Doctor, Bhupendra P. Tsim, Karl W. K. Siow, Nina L. TI Special Issue: Proceedings of the IXth International Meeting on Cholinesterases Preface SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Editorial Material C1 [Tsim, Karl W. K.; Siow, Nina L.] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China. [Tsim, Karl W. K.; Siow, Nina L.] Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China. [Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD USA. RP Tsim, KWK (reprint author), Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China. EM botsim@ust.hk NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 1 EP 2 DI 10.1016/j.cbi.2008.06.001 PG 2 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500001 PM 18582448 ER PT J AU Chilukuri, N Sun, W Naik, RS Parikh, K Tang, L Doctor, BP Saxena, A AF Chilukuri, Nageswararao Sun, Wei Naik, Ramachandra S. Parikh, Kalpana Tang, Lin Doctor, Bhupendra P. Saxena, Ashima TI Effect of polyethylene glycol modification on the circulatory stability and immunogenicity of recombinant human butyrylcholinesterase SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Organophosphorus compounds; Monomeric butyrylcholinesterase; Polyethylene glycosylation; Bioscavenger; Circulatory stability ID GUINEA-PIGS; ACETYLCHOLINESTERASE; TOXICITY; SOMAN; PROTECTION; PRETREATMENT; CHOLINESTERASE; PROPHYLAXIS; ANIMALS; MONKEYS AB The therapeutic value of human serum butyrylcholinesterase (Hu BChE) as a bioscavenger of chemical warfare agents is due to its high reactivity with organophosphorus compounds and prolonged circulatory stability. Native Hu BChE is mostly tetrameric in form while the enzyme produced using molecular cloning technology is a mixture of tetramers, dimers, and monomers. Previous studies revealed that monomers and dimers of recombinant human (rHu) BChE cleared rapidly from the circulation of mice compared to tetrameric rHU BChE and native Hu BChE, which have mean residence times (MRTs) of 18 h and 45 h, respectively. It was also shown that polyethylene glycol-20K (PEG) modification of tetrameric rHu BChE Prolonged its circulatory stability and bioavailability in vivo. The goal of this study was to determine if modification with PEG Could prolong the Circulatory stability and eliminate the immunogenicity of monomeric rHu BChE. Monomeric rHu BChE was expressed in human 293A cells using a cDNA lacking the 45 amino acid tetramerization domain from the carboxyl terminus and the adenovirus expression system. The catalytic and inhibitory properties Of purified monomeric rHu BChE were similar to those for native Hu BChE and were not affected by PEG modification. As expected, monomeric rHu BChE rapidly cleared from the circulation of mice (MRT = 3.2 +/- 0.3 h) while monomeric PEG-rHu BChE demonstrated significant improvement in its bioavailability and circulatory stability in blood (MRT = 31.4 +/- 5.4 h). However, a second injection of monomeric PEG-rHu BChE, 28 days after the first, displayed a much shorter MRT = 11.6 +/- 0.4 h, and circulating anti-monomeric PEG-rHu BChE antibodies were detected in the blood of mice. These results suggest that PEG modification increased the circulatory stability of monomeric rHu BChE but failed to reduce or eliminate its immunogenicity. Published by Elsevier Ireland Ltd C1 [Chilukuri, Nageswararao; Sun, Wei; Naik, Ramachandra S.; Parikh, Kalpana; Tang, Lin; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Chilukuri, N (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM nageswararao.chilukuri@amedd.army.mil NR 25 TC 18 Z9 18 U1 0 U2 3 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 255 EP 260 DI 10.1016/j.cbi.2008.05.020 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500048 PM 18603232 ER PT J AU Luo, CY Tong, M Maxwell, DM Saxena, A AF Luo, Chunyuan Tong, Min Maxwell, Donald M. Saxena, Ashima TI Comparison of oxime reactivation and aging of nerve agent-inhibited monkey and human acetylcholinesterases SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Acetylcholinesterase; Nerve agent; Oxime; Rhesus monkey; Cynomolgus monkey; African green monkey ID DIFFERENT ORGANOPHOSPHORUS COMPOUNDS; ERYTHROCYTE ACETYLCHOLINESTERASE; PYRIDINIUM SALTS; SOMAN; TABUN; HI-6; SARIN; RAT; ABILITY; INVIVO AB Non-human primates are valuable animal models that are used for the evaluation of nerve agent toxicity as well as antidotes and results from animal experiments are extrapolated to humans. It has been demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited acetylcholinesterase (AChE). If the in vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely that the results of an in vivo animal study will reliably extrapolate to humans. Therefore, the goal of this study was to compare the aging and reactivation of human and different monkey (Rhesus, Cynomolgus, and African Green) AChEs inhibited by GF, GD, and VR. The oximes examined include the traditional oxime 2-PAM, two H-oximes HI-6 and HLo-7, and the new candidate oxime MMB4. Results indicate that oxime reactivation of all three monkey AChEs was very similar to human AChE. The maximum difference in the second-order reactivation rate constant between human and three monkey AChEs or between AChEs from different monkey species was 5-fold. Aging rate constants of GF-, GD-,and VR-inhibited monkey AChEs were very similar to human AChE except for GF-inhibited monkey AChEs, which aged 2-3 times faster than the human enzyme. The results of this study suggest that all three monkey species are Suitable animal models for nerve agent antidote evaluation since monkey AChEs possess similar biochemical/pharmacological properties to human AChE. Published by Elsevier Ireland Ltd C1 [Luo, Chunyuan; Tong, Min; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Maxwell, Donald M.] USA, Med Res Inst Chem Def, Edgewood, MD 21010 USA. RP Luo, CY (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Chunyuan.luo@us.army.mil NR 25 TC 28 Z9 30 U1 0 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 261 EP 266 DI 10.1016/j.cbi.2008.04.034 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500049 PM 18555982 ER PT J AU Saxena, A Sun, W Dabisch, PA Hulet, SW Hastings, NB Jakubowski, EM Mioduszewski, RJ Doctor, BP AF Saxena, Ashima Sun, Wei Dabisch, Paul A. Hulet, Stanley W. Hastings, Nicholas B. Jakubowski, Edward M. Mioduszewski, Robert J. Doctor, Bhupendra P. TI Efficacy of human serum butyrylcholinesterase against sarin vapor SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Human serum butyrylcholinesterase; Sarin vapor; Gottingen minipigs; Bioscavenger; Efficacy ID SOMAN-INDUCED SEIZURES; ACETYLCHOLINESTERASE ACTIVITY; NERVE AGENTS; GUINEA-PIGS; HALF-LIFE; PROTECTION; RATS; CHOLINESTERASE; PRETREATMENT; TOXICITY AB Human serum butyrylcholinesterase (Hu BChE) is Currently under advanced development as a pretreatment drug for organophosphate (OP) poisoning in humans. It was shown to protect mice, rats, guinea pigs, and monkeys against Multiple LD50 challenges of OP nerve agents by i.v. or s.c. bolus injections. Since inhalation is the most likely route of exposure to OP nerve agents on the battlefield or in public places, the aim of this Study was to evaluate the efficacy of Hu BChE against whole-body inhalation exposure to satin (GB) vapor. Male Gottingen minipigs were subjected to one of the following treatments: (I) air exposure: (2) GB vapor exposure; (3) pretreatment with 3 mg/kg of Hu BChE followed by GB vapor exposure; (4) pretreatment with 6.5 mg/kg of Hu BChE followed by GB vapor exposure; (5) pretreatment with 7.5 mg/kg of HU BChE followed by GB vapor exposure. Hu BChE was administered by i.m. injection, 24h prior to whole-body exposure to GB vapor at a concentration of 4.1 mg/m(3) for 60 min, a dose lethal to 99% of untreated exposed pigs (LCt99). EEG, ECG, and pupil size were monitored throughout exposure, and blood drawn from a Surgically implanted jugular catheter before and throughout the exposure period, was analyzed for acetylcholinesterase (AChE) and BChE activities, and the amount of GB present in plasma. All animals exposed to GB vapor alone or pretreated with 3 or 6.5 mg/kg of Hu BChE, died following exposure to GB vapor. All five animals pretreated with 7.5 mg/kg of Hu BChE survived the GB exposure. The amount of GB bound in plasma was 200-fold higher compared to that from plasma of pigs that did not receive Hu BChE, suggesting that Hu BChE was effective in scavenging GB in blood. Additionally, pretreatment with 7.5 mg/kg of Hu BChE prevented cardiac abnormalities and seizure activity observed in untreated animals and those treated with lower doses of Hu BChE. Published by Elsevier Ireland Ltd C1 [Saxena, Ashima; Sun, Wei; Hastings, Nicholas B.; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Dabisch, Paul A.; Hulet, Stanley W.; Jakubowski, Edward M.; Mioduszewski, Robert J.] Edgewood Chem Biol Ctr, Operat Toxicol Team, Aberdeen Proving Ground, MD 21010 USA. RP Saxena, A (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ashima.saxena@us.army.mil NR 28 TC 19 Z9 19 U1 0 U2 7 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 267 EP 272 DI 10.1016/j.cbi.2008.05.022 PG 6 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500050 PM 18597747 ER PT J AU Masson, P Nachon, F Broomfield, CA Lenz, DE Verdier, L Schopfer, LM Lockridge, O AF Masson, Patrick Nachon, Florian Broomfield, Clarence A. Lenz, David E. Verdier, Laurent Schopfer, Lawrence M. Lockridge, Oksana TI A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Butyrylcholinesterase; Acetylcholinesterase; Catalytic bioscavenger; Organophosphorus compound ID ANHYDRIDE HYDROLASE ACTIVITY; RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; AMINO-ACID SUBSTITUTION; CHEMICAL WARFARE AGENTS; HUMAN ACETYLCHOLINESTERASE; PSEUDOMONAS-DIMINUTA; ENZYMATIC-HYDROLYSIS; ACTIVE-SITE; SOMAN; PHOSPHOTRIESTERASE AB Wild-type human butyrylcholinesterase (BuChE) has proven to be an efficient bioscavenger for protection against nerve agent toxicity. Human acetylcholinesterase (AChE) has a similar potential. A limitation to their usefulness is that both cholinesterases (ChEs) react stoichiometrically with organophosphosphorus (OP) esters. Because OPs can be regarded as pseudo-substrates for which the dephosphylation rate constant is almost zero, several strategies have been attempted to promote the dephosphylation reaction. Oxime-mediated reactivation of phosphylated ChEs generates a turnover, but it is too slow to make pseudo-catalytic scavengers of pharmacological interest. Alternatively, it was hypothesized that ChEs could be converted into OP hydrolases by using rational site-directed mutagenesis based upon the crystal structure of ChEs. The idea was to introduce a nucleophile into the oxyanion hole, at an appropriate position to promote hydrolysis of the phospho-serine bond via a base catalysis mechanism. Such mutants, if they showed the desired catalytic and pharmacokinetic properties, could be used as catalytic scavengers. The first mutant of human BuChE that was capable of hydrolyzing OPs was G117H. It had a slow rate. Crystallographic study of the G117H mutant showed that hydrolysis likely occurs by activation of a water molecule rather than direct nucleophilic attack by H117. Numerous BuChE mutants were made later, but none of them was better than the G117H mutant at hydrolyzing OPs, with the exception of soman. Soman aged too rapidly to be hydrolyzed by G117H. Hydrolysis was however accomplished with the double mutant G117H/E197Q, which did not age after phosphonylation with soman. Multiple mutations in the active center of human and Bungarus AChE led to enzymes displaying low catalytic activity towards OPs and unwanted kinetic complexities. A new generation of human AChE mutants has been designed with the assistance of molecular modelling and computational methods. According to the putative water-activation mechanism of G117H BChE, a new histidine/aspartate dyad was introduced into the active center of human AChE at the optimum location for hydrolysis of the OP adduct. Additional mutations were made for optimizing activity of the new dyad. It is anticipated that these new mutants will have OP hydrolase activity. (C) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Masson, Patrick; Nachon, Florian] Ctr Rech Serv Sante Armees, Dept Toxicol, Enzymol Unit, F-38702 La Tronche, France. [Broomfield, Clarence A.; Lenz, David E.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. [Verdier, Laurent] Ctr Etud Bouchet, F-91740 Vert Le Petit, France. [Schopfer, Lawrence M.; Lockridge, Oksana] Univ Nebraska, Med Ctr, Eppley Inst, Omaha, NE 68198 USA. RP Masson, P (reprint author), Ctr Rech Serv Sante Armees, Dept Toxicol, Enzymol Unit, BP 87, F-38702 La Tronche, France. EM pmasson@unmc.edu RI Masson, Patrick/J-3964-2013 OI Masson, Patrick/0000-0002-7837-3662 NR 66 TC 48 Z9 50 U1 0 U2 8 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 273 EP 280 DI 10.1016/j.cbi.2008.04.005 PG 8 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500051 PM 18508040 ER PT J AU Naik, RS Doctor, BP Saxena, A AF Naik, Ramachandra S. Doctor, Bhupendra P. Saxena, Ashima TI Comparison of methods used for the determination of cholinesterase activity in whole blood SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Butyrylcholinesterase; Acetylcholinesterase; Cholinesterase inhibitors; Animal whole blood; Cholinesterase activity ID ACETYLCHOLINESTERASE ACTIVITY; PLASMA AB Cholinesterases (ChEs) are classified as either acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) based on their substrate and inhibitor specificity. Organophosphate and carbamate compounds commonly represented by herbicides, pesticides, and nerve gases irreversibly inhibit ChEs. Therefore, exposure to organophosphates and carbamates is normally assessed by measuring ChE activity in blood. There are two approaches for measuring AChE and BChE activity present in whole blood: (1) separating blood into erythrocytes, which contain only AChE, and plasma which contains only BChE, to measure their activity individually, or (2) use a BChE-specific inhibitor to measure the activity of AChE in whole blood. A number of studies have reported the use of different inhibitors for the simultaneous measurement of AChE and BChE activities. However, the inhibitors used for completely inhibiting BChE activity also inhibited AChE activity leading to errors in reported values. The goal of this study was to find the most accurate and simple method for the simultaneous determination of AChE and BChE activity in animal whole blood. Solutions containing human AChE and BChE in various proportions were prepared and AChE and BChE activities were measured using three reported methods. Results demonstrate that ethopropazine and (-) huperzine A appear to be the most specific ChE inhibitors. Preliminary results with human and animal whole blood suggest that 20 mu M ethopropazine and 500 nM (-) huperzine A can be used for measuring AChE and BChE activities across species. (C) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Naik, Ramachandra S.; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Naik, RS (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM ramachandra.naik@us.army.mil NR 11 TC 9 Z9 9 U1 0 U2 5 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 298 EP 302 DI 10.1016/j.cbi.2008.05.002 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500055 PM 18555980 ER PT J AU Chilukuri, N Duysen, EG Parikh, K Sun, W Doctor, BP Lockridge, O Saxena, A AF Chilukuri, Nageswararao Duysen, Ellen G. Parikh, Kalpana Sun, Wei Doctor, Bhupendra P. Lockridge, Oksana Saxena, Ashima TI Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Human butyrylcholinesterase; Adenovirus; Gene therapy; Organophosphorus compounds; Bioscavenger ID RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE; HUMAN-SERUM CHOLINESTERASE; HUMORAL IMMUNE-RESPONSES; GUINEA-PIGS; TOXICITY; SOMAN; PROTECTION; ACETYLCHOLINESTERASE; MICE; ORGANOPHOSPHATES AB Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents, pesticide intoxication, and cocaine overdose. However, its widespread application is hampered by difficulties in large-scale production of the native protein from human plasma and/or availability as a recombinant protein suitable for use in vivo. This limitation may be resolved by in vivo delivery and expression of the Hu BChE gene. In this Study, recombinant (r) adenoviruses (Ads) encoding full-length and truncated rHu BChEs were tested for in vivo expression in mice. Mice injected with these rAds intraperitoneally failed to express rHu BChE. However,a single tail vein injection of both rAds resulted in persistent high serum levels of rHu BChE in BChE knockout mice, which peaked on days 4/5 at 377 +/- 162 U/ml for full-length rHu BChE and 574 +/- 143 U/ml fort truncated rHu BChE. These activity levels are orders of magnitude higher than 1.9 U/ml of mouse BChE present in wild-type Mouse serum. Thereafter, rHu BChE levels dropped rapidly and very little or no activity was detected in the serum 10 days post-virus administration. In conclusion, the present study demonstrates the potential of rAd-mediated Hu BChE gene therapy to Counteract Multiple lethal doses of chemical warfare nerve agent toxicity. Published by Elsevier Ireland Ltd C1 [Chilukuri, Nageswararao; Parikh, Kalpana; Sun, Wei; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Duysen, Ellen G.; Lockridge, Oksana] Univ Nebraska Med Ctr, Eppley Inst, Omaha, NE USA. RP Chilukuri, N (reprint author), Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM Nageswararao.chilukuri@na.amedd.army.mil OI Duysen, Ellen/0000-0002-0128-9032 NR 33 TC 13 Z9 13 U1 1 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 327 EP 331 DI 10.1016/j.cbi.2008.04.009 PG 5 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500061 PM 18499092 ER PT J AU Haigh, JR Johnston, SR Peppernay, A Mattern, PJ Garcia, GE Doctor, BP Gordon, RK Aisen, PS AF Haigh, Julian R. Johnston, Scott R. Peppernay, Adam Mattern, Patrick J. Garcia, Gregory E. Doctor, Bhupendra P. Gordon, Richard K. Aisen, Paul S. TI Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: Next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Huperzine A; Pyridostigmine bromide; Soman; WRAIR whole blood cholinesterase assay ID ALZHEIMERS-DISEASE; CHOLINESTERASES; INHIBITION; (-)-HUPERZINE; PRETREATMENT; VOLUNTEERS; TACRINE; E2020; DRUG AB As part of a phase Ib clinical trial to determine the tolerability and safety of the highly specific acetylcholinesterase (AChE) inhibitor huperzine A, twelve (12) healthy elderly individuals received an escalating dose regimen of huperzine A (100, 200, 300, and 400 mu g doses, twice daily for a week at each dose), with three (3) individuals as controls receiving a placebo. Using the WRAIR whole blood cholinesterase assay, red blood cell AChE and plasma butyrylcholinesterase (BChE) were measured in unprocessed whole blood samples from the volunteers following each dose, and then for up to 48 h following the final and highest (400 mu g) dose to monitor the profile of inhibition and recovery of AChE. Significant inhibition of AChE was observed, ranging from 30-40% after 100 mu g to >50% at 400 mu g, and peaking 1.5 h after the last dose. Gradual recovery of AChE activity then Occurs, but even 48 h after the last dose Fed blood cell AChE was about 10% below control (pre-dose) values. Huperzine A levels in plasma peaked 1.5 h after the final 400 mu g dose (5.47 +/- 2.15 ng/mL). Plasma BChE was unaffected by huperzine A treatment (as expected). Aliquots of huperzine A-containing (from three individuals) and placebo blood samples were exposed ex vivo to the irreversible nerve agent soman (GD) for 10 min, followed by removal Of unbound huperzine and soman from the blood by passing through a small C-18 reverse phase spin column. Eluted blood was diluted in buffer, and aliquots taken at various time intervals for AChE and BChE activity measurement to determine the time taken to achieve full return in activity of the free enzyme (dissociation from the active site of AChE by huperzine A), and thus the proportion of AChE that can be Protected from soman exposure. Huperzine A-inhibited red blood cell (RBC) AChE activity was restored almost to the level that was initially inhibited by the drug. The increased doses of huperzine A used were well tolerated by these patients and in this ex vivo study sequestered more red blood cell AChE than has been previously demonstrated for pyridostigmine bromide (PB), indicating the potential improved prophylaxis against organophosphate (OP) poisoning. Published by Elsevier Ireland Ltd C1 [Haigh, Julian R.; Johnston, Scott R.; Peppernay, Adam; Mattern, Patrick J.; Garcia, Gregory E.; Doctor, Bhupendra P.; Gordon, Richard K.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Aisen, Paul S.] Georgetown Univ, Med Ctr, Dept Neurol, Washington, DC 20007 USA. RP Gordon, RK (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Rd, Silver Spring, MD 20910 USA. EM Richard.Gordon@amedd.army.mil NR 20 TC 13 Z9 14 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 380 EP 386 DI 10.1016/j.cbi.2008.04.033 PG 7 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500073 PM 18572153 ER PT J AU Coleman, BR Ratcliffe, RH Oguntayo, SA Shi, XR Doctor, BP Gordon, RK Nambiar, MP AF Coleman, Brian R. Ratcliffe, Ruthie H. Oguntayo, Samuel A. Shi, Xuerong Doctor, Bhupendra P. Gordon, Richard K. Nambiar, Madhusoodana P. TI [+]-Huperzine A treatment protects against N-methyl-D-aspartate-induced seizure/status epilepticus in rats SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Acetylcholinesterase; Organophosphate; Radiotelemetry; Neuroprotection; N-methyl-D-aspartate receptor antagonists; Chemical warfare nerve agents ID SOMAN-INDUCED SEIZURES; ORGANOPHOSPHORUS NERVE AGENTS; HUPERZINE-A; CHEMICAL WARFARE; CHOLINESTERASE INHIBITOR; ANTICONVULSANT TREATMENT; ALZHEIMERS-DISEASE; ACID; ACETYLCHOLINESTERASE; EXPOSURE AB The toxicity of organophosphorous (OP) nerve agents is attributed to their irreversible inhibition of acetylcholinesterase (AChE), which leads to excessive accumulation of acetylcholine (ACh) and is followed by the release of excitatory amino acids (EAA). EAAs sustain seizure activity and induce neuropathology due to over-stimulation of N-methyl-D-aspartate (NMDA) receptors. Huperzine A (Hup A), a blood-brain barrier permeable selective reversible inhibitor of AChE, has been shown to reduce EAA-induced cell death by interfering with glutamate receptor-gated ion channels in primary neuronal cultures. Although [-]-Hup A, the natural isomer, inhibits AChE approximately 38-fold more potently than [+]-Hup A, both [-]- and [+]-Hup A block the NMDA channel similarly. Here, we evaluated the protective efficacy of [+]-Hup A for NMDA-induced seizure in a rat model. Rats implanted with radiotelemetry probes to record electroencephalography (EEC), electrocardiography (ECG), body temperature, and physical activity were administered various doses of [+]-Hup A (intramuscularly) and treated with 20 mu g/kg NMDA (intracerebroventricular) 20-30 min later. For post-exposure, rats were treated with [+]-Hup A (3 mg/kg, intramuscularly) 1 min after NMDA (20 mu g/kg). Our data showed that pre- and post-exposure, [+]-Hup A (3 mg/kg) protects animals against NMDA-induced seizures. Also, NMDA-administered animals showed increased survival following [+]-Hup A treatment. [+]-Hup A has no visible effect on EEG, heart-rate, body temperature, OF physical activity, indicating a reduced risk of side effects, toxicity, or associated pathology. Our results suggest that [+]-Hup A Protects against seizure and status epilepticus (SE) by blocking NMDA-induced excitotoxicity in vivo. We propose that [+]-Hup A, or a unique combination of [+]- and [-]-Hup A, may prove to be effective for pre- and post-exposure treatment of lethal doses of OP-induced neurotoxicity. Published by Elsevier Ireland Ltd C1 [Coleman, Brian R.; Ratcliffe, Ruthie H.; Oguntayo, Samuel A.; Shi, Xuerong; Doctor, Bhupendra P.; Gordon, Richard K.; Nambiar, Madhusoodana P.] Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. [Nambiar, Madhusoodana P.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Nambiar, MP (reprint author), Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Madhusoodana.nambiar@na.amedd.army.mil RI Ratcliffe, Ruthie/B-6815-2011 NR 48 TC 25 Z9 26 U1 0 U2 0 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 EI 1872-7786 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 387 EP 395 DI 10.1016/j.cbi.2008.05.023 PG 9 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500074 PM 18588864 ER PT J AU Haigh, JR Lefkowitz, LJ Capacio, BR Doctor, BP Gordon, RK AF Haigh, Julian R. Lefkowitz, Lee J. Capacio, Benedict R. Doctor, Bhupendra P. Gordon, Richard K. TI Advantages of the WRAIR whole blood cholinesterase assay: Comparative analysis to the micro-Ellman, Test-mate ChE (TM) and Michel (Delta pH) assays SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Acetylcholinesterase; Bland-Altman; Butyrylcholinesterase; Micro-Ellman; Michel (Delta pH); Soman; Test-mate; WRAIR whole blood cholinesterase assay AB Red blood cell AChE (RBC-AChE) and plasma BChE can be used as sensitive biomarkers to detect exposure to OP nerve agents, pesticides, and cholinergic drugs. In a comparative Study, RBC-AChE and serum BChE activities in whole blood was obtained from forty seven healthy male and female human volunteers,and then exposed separately ex vivo to three OP nerve agents (soman (GD), sarin (GB) and VX) to generate a wide range of inhibition of AChE and BChE activity (up to 90% of control). These samples were measured using four different ChE assays: (i) colorimetric microEllman (using DTNB at 412 nm), (ii) Test-mate ChE field kit (also based on the Ellman assay), (iii) Michel (delta pH), and (iv) the Walter Reed Army Institute of Research Whole Blood (WRAIR WB) cholinesterase assay. The WRAIR assay is a modified Ellman method using DTP at 324 nm (which minimizes hemoglobin interference and improves sensitivity), and determines AChE and BChE in a small whole blood sample simultaneously. Scatter plots of RBC-AChE activities were determined using the WRAIR ChE assay versus the micro-Ellman, Test-mateTM and Michel after exposure to varying concentrations of soman, sarin and VX. Regression analyses yielded mostly lineal, relationships with high correlations (r2 = 0.83-0.93) for RBC-AChE values in the WRAIR assay compared to the alternate methods. For the plasma BChE measurements, individual human values were significantly more variable (as expected), resulting in lower correlations using WRAIR ChE versus the alternate assays (r2 values 0.5 - 0.6). To circumvent the limitations of simple correlation analysis, Bland and Altman analysis for comparing two independent measurement techniques was performed. For example, a Bland and Altman plot of the ratio of the WRAIR whole blood AChE and Michel AChE (plotted on the y-axis) vs. the average of the two methods (x-axis) shows that the majority of the individual AChE values are within +/- 1.96 S.D. of the mean difference, indicating that the two methods may be used interchangeably with a high degree of confidence. The WRAIR ChE assay can be thus be used as a reliable inter-conversion assay when comparing results from laboratory-based (Michel) and field-based (Test-mateTM ChE kit), which use different methodology and report in different units of AChE activity. Published by Elsevier Ireland Ltd C1 [Haigh, Julian R.; Doctor, Bhupendra P.; Gordon, Richard K.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Lefkowitz, Lee J.] Walter Reed Army Inst Res, Div Regulated Labs, Silver Spring, MD 20910 USA. [Capacio, Benedict R.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Gordon, RK (reprint author), Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM Richard.Gordon@amedd.army.mil NR 4 TC 36 Z9 37 U1 0 U2 4 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 417 EP 420 DI 10.1016/j.cbi.2008.04.032 PG 4 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500080 PM 18555983 ER PT J AU Sun, W Doctor, BP Lenz, DE Saxena, A AF Sun, Wei Doctor, Bhupendra P. Lenz, David E. Saxena, Ashima TI Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article; Proceedings Paper CT 9th International Meeting on Cholinesterases CY MAY 06-10, 2007 CL Suzhou, PEOPLES R CHINA DE Long-term toxicity; Soman; Human butyrylcholinesterase; Cynomolgus monkey; Cholinesterase activity AB Human serum butyrylcholinesterase (Hu BChE)was demonstrated previously to be an effective prophylaxis that can protect animals from organophosphate nerve agents. However, in most of those studies, the maximum dose used to challenge animals was low (<2 x LD50), and the health of these animals was monitored for only up to 2 weeks. In this study, six cynomolgus monkeys received 75 mg of Hu BChE followed by sequential doses (1.5, 2.0. 2.0x LD50) ofsornan 10 h later for a total challenge of 5.5x LD50. Four surviving animals that did not show any signs of soman intoxication were transferred to WRAIR for the continuous evaluation of long-term health effects for 14 months. Each month, blood was drawn from these monkeys and analyzed for serum chemistry and hematology parameters, blood acetylcholinesterase (AChE) and BChE levels. Based on the serum chemistry and hematology parameters measured, no toxic effects or any organ malfunctions were observed Lip to 14 months following Hu BuChE protection against exposure to 5.5x LD50 of soman. In conclusion, Hu BChE pretreatment not only effectively protects monkeys from soman-induced toxicity of the immediate acute phase but also for a long-term Outcome. (C) 2008 Elsevier Ireland Ltd. All rights reserved. C1 [Sun, Wei; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Lenz, David E.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Sun, W (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM wei.sun@us.army.mil NR 5 TC 8 Z9 8 U1 0 U2 2 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD SEP 25 PY 2008 VL 175 IS 1-3 SI SI BP 428 EP 430 DI 10.1016/j.cbi.2008.04.036 PG 3 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA 361EO UT WOS:000260110500083 PM 18674756 ER PT J AU Miklossy, J Kasas, S Zurn, AD McCall, S Yu, S McGeer, PL AF Miklossy, Judith Kasas, Sandor Zurn, Anne D. McCall, Sherman Yu, Sheng McGeer, Patrick L. TI Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis SO JOURNAL OF NEUROINFLAMMATION LA English DT Article ID ELECTRON-MICROSCOPY; TREPONEMA-PALLIDUM; ALZHEIMERS-DISEASE; REITER TREPONEME; ULTRA-VIRUS; MORPHOLOGY; BRAIN; SPIROCHETOSIS; TRANSFORMATION; CULTIVATION AB Background: The long latent stage seen in syphilis, followed by chronic central nervous system infection and inflammation, can be explained by the persistence of atypical cystic and granular forms of Treponema pallidum. We investigated whether a similar situation may occur in Lyme neuroborreliosis. Method: Atypical forms of Borrelia burgdorferi spirochetes were induced exposing cultures of Borrelia burgdorferi ( strains B31 and ADBI) to such unfavorable conditions as osmotic and heat shock, and exposure to the binding agents Thioflavin S and Congo red. We also analyzed whether these forms may be induced in vitro, following infection of primary chicken and rat neurons, as well as rat and human astrocytes. We further analyzed whether atypical forms similar to those induced in vitro may also occur in vivo, in brains of three patients with Lyme neuroborreliosis. We used immunohistochemical methods to detect evidence of neuroinflammation in the form of reactive microglia and astrocytes. Results: Under these conditions we observed atypical cystic, rolled and granular forms of these spirochetes. We characterized these abnormal forms by histochemical, immunohistochemical, dark field and atomic force microscopy (AFM) methods. The atypical and cystic forms found in the brains of three patients with neuropathologically confirmed Lyme neuroborreliosis were identical to those induced in vitro. We also observed nuclear fragmentation of the infected astrocytes using the TUNEL method. Abundant HLA-DR positive microglia and GFAP positive reactive astrocytes were present in the cerebral cortex. Conclusion: The results indicate that atypical extra- and intracellular pleomorphic and cystic forms of Borrelia burgdorferi and local neuroinflammation occur in the brain in chronic Lyme neuroborreliosis. The persistence of these more resistant spirochete forms, and their intracellular location in neurons and glial cells, may explain the long latent stage and persistence of Borrelia infection. The results also suggest that Borrelia burgdorferi may induce cellular dysfunction and apoptosis. The detection and recognition of atypical, cystic and granular forms in infected tissues is essential for the diagnosis and the treatment as they can occur in the absence of the typical spiral Borrelia form. C1 [Miklossy, Judith; Yu, Sheng; McGeer, Patrick L.] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada. [Kasas, Sandor] Ecole Polytech Fed Lausanne, Lab Phys Mat Vivante, CH-1015 Lausanne, Switzerland. [Kasas, Sandor] Univ Lausanne, Dept Biol Cellulaire & Morphol, CH-1005 Lausanne, Switzerland. [Zurn, Anne D.] Univ Lausanne Hosp, Dept Expt Surg, CH-1011 Lausanne, Switzerland. [McCall, Sherman] USA, Med Res Inst Infect Dis, Pathol Lab, Ft Detrick, MD 21702 USA. RP Miklossy, J (reprint author), Univ British Columbia, Kinsmen Lab Neurol Res, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. EM judithmiklossy@bluewin.ch; sandor.kasas@epfl.ch; Anne.Zurn@chuv.ch; sherman.mccall@us.army.mil; Sheng_Yu@hotmail.com; mcgeerpl@interchange.ubc.ca FU Pacific Alzheimer Foundation, Vancouver, Canada FX We would like to express our particular thanks for P. Darekar who has done the major part of the cell culture, histology and immunohistochemical analyses. It was a tremendous work. We are grateful for her. We are also grateful for P. Hansma. The AFM work has been done in his laboratory where the atmosphere, rigor and enthusiasm were excellent and unforgettable. We would like to thank all those colleagues and friends who strongly supported this work. We are grateful for J. and L. Krasinsky. Their generous help contributed to the realization of this work. The work was supported by grants from the Societe Academique Vaudoise. We are grateful for the support of the Institute of Histology and Embryology, University of Fribourg, Switzerland. The work was also supported by the Pacific Alzheimer Foundation, Vancouver, Canada NR 74 TC 46 Z9 49 U1 1 U2 12 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD SEP 25 PY 2008 VL 5 AR 40 DI 10.1186/1742-2094-5-40 PG 18 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 359HS UT WOS:000259977600001 PM 18817547 ER PT J AU Best, EPH Boyd, WA AF Best, Elly P. H. Boyd, William A. TI A carbon flow-based modelling approach to ecophysiological processes and biomass dynamics of Vallisneria americana, with applications to temperate and tropical water bodies SO ECOLOGICAL MODELLING LA English DT Article DE submersed macrophyte; carbon flow; biomass; potential persistence; Vallisneria; model ID MYRIOPHYLLUM-SPICATUM L; UPPER MISSISSIPPI RIVER; SUBMERSED MACROPHYTES; AQUATIC VEGETATION; CONSTRUCTION COST; GROWTH; PHOTOSYNTHESIS; PRODUCTIVITY; IRRADIANCE; PATTERNS AB A dynamic simulation modelling approach to submersed plant biomass formation has been developed to provide a tool for water resource managers to evaluate key environmental conditions in which submersed aquatic vegetation (SAV) would persist or produce excessive biomass with ensuing consequences for the systems in which they grow, either or not affected by management measures. The model species is Vallisneria americana (American wildcelery) and the model name is VALLA. The model describes major, carbon flow-based ecophysiological processes and biomass dynamics of a common plant species. The model contains unique descriptions of. (1) species-characteristic vertical distribution of shoot biomass in the water column, that enables the calculation of the fraction of irradiance actually available for absorption by the SAV, (2) recalculation procedures of this vertical distribution with daily changes in water level and/or shoot mass removal at various levels within the water column, that enables the evaluation of regrowth potential; (3) species-characteristic effects of current velocity on photosynthesis, that enables the evaluation of the effects of hydraulic water body alterations; and (4) relationships of plant process parameters with site-specific climate, that enables the evaluation of effects of different climates. Generally, a good fit was found between simulated and measured biomass in the field. Sensitivity analysis showed that the model is very sensitive to changes in process parameters influencing carbon flow. Published by Elsevier B.V. C1 [Best, Elly P. H.; Boyd, William A.] USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Best, EPH (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Elly.P.Best@erdc.usace.army.mil NR 43 TC 0 Z9 0 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3800 J9 ECOL MODEL JI Ecol. Model. PD SEP 24 PY 2008 VL 217 IS 1-2 BP 117 EP 131 DI 10.1016/j.ecolmodel.2008.06.006 PG 15 WC Ecology SC Environmental Sciences & Ecology GA 342VL UT WOS:000258811600010 ER PT J AU Lee, J Chopra, N Eom, SH Zheng, Y Xue, JG So, F Shi, JM AF Lee, Jaewon Chopra, Neetu Eom, Sang-Hyun Zheng, Ying Xue, Jiangeng So, Franky Shi, Jianmin TI Effects of triplet energies and transporting properties of carrier transporting materials on blue phosphorescent organic light emitting devices SO APPLIED PHYSICS LETTERS LA English DT Article ID TRANSIENT ANALYSIS; WHITE-LIGHT; ELECTROPHOSPHORESCENCE; EFFICIENT; CONFINEMENT AB We have studied the effects of the hole transporting layers and electron transporting layers on the device efficiencies of iridium(III) bis[(4,6-di-fluorophenyl)-pyridinato-N,C2'] picolinate (FIrpic) doped 3,5'-N,N'-dicarbazole-benzene (mCP) host blue phosphorescent organic light emitting diodes. We found that the device efficiency is very sensitive to the hole transporting materials used and both the triplet energy and carrier transport properties affect the device efficiency. On the other hand, there is no apparent correlation between the device efficiency and the triplet energy of the electron transporting material used. Instead, the device efficiency is affected by the electron mobility of the electron transporting layer only. (C) 2008 American Institute of Physics. C1 [Lee, Jaewon; Chopra, Neetu; Eom, Sang-Hyun; Zheng, Ying; Xue, Jiangeng; So, Franky] Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. [Shi, Jianmin] USA, Res Lab, Opt Elect Div, Adelphi, MD 20783 USA. [Shi, Jianmin] USA, Res Lab, Sensor Div, Adelphi, MD 20783 USA. RP Lee, J (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM fso@mse.ufl.edu RI Chopra, Neetu/F-3307-2012; Zheng, Ying/C-2193-2011; Xue, Jiangeng/A-5373-2008; OI Chopra, Neetu/0000-0002-0114-532X; Xue, Jiangeng/0000-0002-0932-3469 FU Department of Energy Office of Energy Efficiency and Renewable Energy [DE-FC26-06NT42855] FX This work was supported by the Department of Energy Office of Energy Efficiency and Renewable Energy (Award No. DE-FC26-06NT42855). NR 23 TC 143 Z9 146 U1 2 U2 17 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 22 PY 2008 VL 93 IS 12 AR 123306 DI 10.1063/1.2978235 PG 3 WC Physics, Applied SC Physics GA 356SY UT WOS:000259799100087 ER PT J AU Hammamieh, R Ribot, WJ Abshire, TG Jett, M Ezzell, J AF Hammamieh, Rasha Ribot, Wilson J. Abshire, Terry G. Jett, Marti Ezzell, John TI Activity of the Bacillus anthracis 20 kDa protective antigen component SO BMC INFECTIOUS DISEASES LA English DT Article ID LETHAL FACTOR; MAMMALIAN-CELLS; KINASE-KINASE; TOXIN; SEQUENCE; MACROPHAGES; CLEAVES; PROTEASE; RECEPTOR; PLASMID AB Background: Anthrax is caused by Bacillus anthracis that produce two exotoxins, lethal toxin and edema toxin. The lethal toxin is composed of the lethal factor (LF) complexed with the cell binding protective antigen (PA(83), 83 kDa). Likewise, the edema factor (EF) binds to the PA(83) to form the edema toxin. Once PA(83) is bound to the host cell surface, a furin-like protease cleaves the full-length, inactive protein into 63 kDa and 20 kDa antigens (PA(63) and PA(20)). PA(63) forms a heptamer and is internalized via receptor mediated endocytosis forming a protease-stable pore, which allows EF and LF to enter the cell and exert their toxic effects. Both proteolytically cleaved protective antigens (PA(63) and PA(20) fragments) are found in the blood of infected animals. The 63 kDa protective antigen PA(63) fragment has been thoroughly studied while little is known about the PA(20). Methods: In this study we examined the role of PA(20) using high throughput gene expression analysis of human peripheral blood mononuclear cells (PBMC) exposed to the PA(20). We constructed a PA mutant in which a Factor X(a) proteolytic recognition site was genetically engineered into the protective antigen PA(83) to obtain PA(20) using limited digestion of this recombinant PA(83) with trypsin. Results: Global gene expression response studies indicated modulation of various immune functions and showed gene patterns indicative of apoptosis via the F(as) pathway in a subset of the lymphoid cells. This finding was extended to include observations of increased Caspase-3 enzymatic activity and the identification of increases in the population of apoptotic, but not necrotic cells, based on differential staining methods. We identified a list of similar to 40 inflammatory mediators and heat-shock proteins that were altered similarly upon exposure of PBMC to either rPA(20) or B. anthracis spores/vegetative cells. Conclusion: This study shows that the PA(20) has an effect on human peripheral blood leukocytes and can induce apoptosis in the absence of other PA components. C1 [Hammamieh, Rasha; Jett, Marti] Walter Reed Army Inst Res, Silver Spring, MD USA. [Abshire, Terry G.; Ezzell, John] USA, Med Res Inst Infect Dis, Diagnost Syst Div, Frederick, MD USA. [Ribot, Wilson J.] USA, Med Res Inst Infect Dis, Bacteriol Div, Frederick, MD USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. EM rasha.hammamieh1@us.army.mil; wilson.ribot@us.army.mil; teresa.geniele.abshire@us.army.mil; marti.jett@us.army.mil; EzzellA55@aol.com NR 28 TC 7 Z9 7 U1 0 U2 3 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1471-2334 J9 BMC INFECT DIS JI BMC Infect. Dis. PD SEP 22 PY 2008 VL 8 AR 124 DI 10.1186/1471-2334-8-124 PG 14 WC Infectious Diseases SC Infectious Diseases GA 362VC UT WOS:000260224200002 PM 18808698 ER PT J AU Carrieri, AH Owens, DJ Schultz, JC AF Carrieri, Arthur H. Owens, David J. Schultz, Jonathan C. TI Infrared Mueller matrix acquisition and preprocessing system SO APPLIED OPTICS LA English DT Article ID OPTICAL COHERENCE TOMOGRAPHY; SCATTERING; SURFACES; ROUGH AB An analog Mueller matrix acquisition and preprocessing system (AMMS) was developed for a photopolarimetric-based sensor with 9.1-12.0 mu m optical bandwidth, which is the middle infrared wavelength-tunable region of sensor transmitter and "fingerprint" spectral band for chemical-biological (analyte) standoff detection. AMMS facilitates delivery of two alternate polarization-modulated CO2 laser beams onto subject analyte that excite/relax molecular vibrational resonance in its analytic mass, primes the photoelastic-modulation engine of the sensor, establishes optimum throughput radiance per backscattering cross section, acquires Mueller elements modulo two laser beams in hexadecimal format, preprocesses (normalize, subtract, filter) these data, and formats the results into digitized identification metrics. Feed for-warding of formatted Mueller matrix metrics through an optimally trained and validated neural network provides pattern recognition and type classification of interrogated analyte. (C) 2008 Optical Society of America C1 [Carrieri, Arthur H.] US Army Res, Dev & Engn Command RDECOM, ECBC, Res & Technol Directorate,ATTN AMSRD ECB RT DL, Aberdeen Proving Ground, MD 21010 USA. [Owens, David J.; Schultz, Jonathan C.] Quetron Syst Inc, Forest Hill, MD 21050 USA. RP Carrieri, AH (reprint author), US Army Res, Dev & Engn Command RDECOM, ECBC, Res & Technol Directorate,ATTN AMSRD ECB RT DL, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA. EM arthur.carrieri@us.army.mil FU The United States Defense Threat Reduction Agency FX The United States Defense Threat Reduction Agency provided financial assistance by sponsoring this work under the auspices of a competitive In-House Laboratory Independent Research proposal. We thank our colleagues Jerry Bottiger (ECBC), Kevin Hung (Advanced Technologies and Applications, Inc.), Jack Copper (NeuralWare), and Erik Roese (ECBC) for consultations regarding topics of aerosol physics, software development, neural network modeling, and on assistance in conducting experiments. NR 20 TC 1 Z9 1 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD SEP 20 PY 2008 VL 47 IS 27 BP 5019 EP 5027 DI 10.1364/AO.47.005019 PG 9 WC Optics SC Optics GA 362JN UT WOS:000260194100026 PM 18806864 ER PT J AU Spik, KW Badger, C Mathiessen, L Tjelle, T Hooper, JW Schmaljohn, C AF Spik, Kristin W. Badger, Catherine Mathiessen, Lacob Tjelle, Torunn Hooper, Jay W. Schmaljohn, Connie TI Mixing of M segment DNA vaccines to Hantaan virus and Puumala virus reduces their immunogenicity in hamsters SO VACCINE LA English DT Article DE hantaviruses; hemorrhagic fever with renal syndrome; DNA vaccines ID NEUTRALIZING ANTIBODY-RESPONSE; ENCEPHALITIS-VIRUS; HEMORRHAGIC-FEVER; PROTECTS HAMSTERS; RENAL SYNDROME; SEOUL-VIRUS; HANTAVIRUSES; VACCINATION; CHALLENGE; ELICITS AB To determine if DNA vaccines for two hantaviruses causing hemorrhagic fever with renal syndrome, Hantaan virus and Puumala virus, are immunogenic when given in combination, we delivered them to hamsters separately or as mixtures by gene gun or by electroporation. Both vaccines elicited neutralizing antibodies when given alone but when they were delivered as a mixture, antibodies to only one of the two hantaviruses Could be detected. In contrast, if the DNAs were given as separate vaccinations to a single animal, responses to both were observed. These Studies suggest that the two DNA vaccines will need to be given as separate administrations. Published by Elsevier Ltd. C1 [Spik, Kristin W.; Badger, Catherine; Hooper, Jay W.; Schmaljohn, Connie] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. [Mathiessen, Lacob; Tjelle, Torunn] Inovio AS, N-0317 Oslo, Norway. RP Schmaljohn, C (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. EM connie.schmaljohn@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU Military Infectious Disease Research Program; U.S. Army Medical Research and Material Command; Inovio FX Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army or the Department of Defense. The research described herein was sponsored by the Military Infectious Disease Research Program, U.S. Army Medical Research and Material Command and by congressionally directed funding to Inovio. Research was conducted in compliance with the Animal Welfare Act and other federal statutes and regulations relating to animals and experiments involving animals and adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, National Research Council, 1996. The facility where this research was conducted is fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International. NR 19 TC 20 Z9 20 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD SEP 19 PY 2008 VL 26 IS 40 SI SI BP 5177 EP 5181 DI 10.1016/j.vaccine.2008.03.097 PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 356TE UT WOS:000259799700017 PM 18482782 ER PT J AU Cai, YH Guo, LD Douglas, TA Whitledge, TE AF Cai, Yihua Guo, Laodong Douglas, Thomas A. Whitledge, Terry E. TI Seasonal variations in nutrient concentrations and speciation in the Chena River, Alaska SO JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES LA English DT Article ID DISSOLVED ORGANIC-MATTER; ARCTIC-OCEAN; TEMPORAL VARIATIONS; YUKON RIVER; LENA RIVER; CARBON; NITROGEN; PHOSPHORUS; BIOGEOCHEMISTRY; WATERSHEDS AB To better understand the seasonal controls on nutrient abundances, speciation, and fluxes in a watershed underlain by discontinuous permafrost, we collected water samples biweekly from the Chena River during 2005-2006 to measure inorganic and organic N, P, and Si in dissolved and particulate phases. Nitrate concentrations were low (8-14 mu M) during the winter and summer dry seasons but were elevated during the spring freshet (15-24 mu M). Ammonium varied from 8 to 13 mu M during the winter but dropped dramatically during the ice-open season to 0.1-3 mM. Phosphate was very low throughout the year (ranging from 0.03 to 0.3 mu M), reflecting the pristine condition of the watershed. Dissolved silica was high in the winter and reached its minimum during the spring freshet. DIN was the dominant species in the total N pool (60%), followed by DON (30%) and PN (10%). Most of the phosphorous was present in the particulate phase (74%), with phosphate and DOP only comprising 19% and 7%, respectively. Seasonal variations in nutrient concentrations and speciation were mostly controlled by the hydrological flow regime and biological activity in the river. Annual nutrient export fluxes from the Chena River during 2005-2006 were 51.1 x 10(6) mole-N, 1.4 x 10(6) mole-P, and 197 x 10(6) mole-Si, corresponding to an annual yield of 9.8 x 10(3) mol-N km(-2), 0.28 x 10(3) mol-P km(-2), and 37.9 x 10(3) mol-Si km(-2), respectively. Within the annual export fluxes, the spring freshet contributed about 18% of TN, 27% of TP, and 10% of Si, while the winter season contributed 11% of TN, 12% of TP, and 20% of Si. Continued climatic warming in northern watersheds will likely increase the export of nutrient species from watersheds. C1 [Cai, Yihua; Guo, Laodong] Univ So Mississippi, Dept Marine Sci, Stennis Space Ctr, MS 39529 USA. [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Ft Wainwright, AK 99703 USA. [Whitledge, Terry E.] Univ Alaska, Inst Marine Sci, Fairbanks, AK 99775 USA. RP Cai, YH (reprint author), Univ So Mississippi, Dept Marine Sci, Stennis Space Ctr, MS 39529 USA. EM laodong.guo@usm.edu RI Guo, Laodong/F-6045-2010 OI Guo, Laodong/0000-0002-5010-1630 FU U. S. National Science Foundation [EAR 0554781, ARC 0436179]; University of Alaska Fairbanks; University of Southern Mississippi,; U.S. Army Alaska FX Acknowledgments. We thank Mindy Juliana, Chuanhao Xu, Arthur Gelvin, and Laura Johnson for field sampling assistance, and the Associate Editor and two anonymous reviewers for their constructive comments. This work was supported in part by the U. S. National Science Foundation (EAR 0554781 and ARC 0436179 to L. G.), the International Arctic Research Center at the University of Alaska Fairbanks, the University of Southern Mississippi, and the U.S. Army Alaska. NR 53 TC 17 Z9 17 U1 1 U2 10 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-8953 EI 2169-8961 J9 J GEOPHYS RES-BIOGEO JI J. Geophys. Res.-Biogeosci. PD SEP 16 PY 2008 VL 113 IS G3 AR G03035 DI 10.1029/2008JG000733 PG 11 WC Environmental Sciences; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Geology GA 351AO UT WOS:000259396600001 ER PT J AU Maxwell, GL Tian, C Risinger, JI Hamilton, CA Barakat, RR AF Maxwell, G. Larry Tian, Chunqiao Risinger, John I. Hamilton, Chad A. Barakat, Richard R. CA A Gynecologic Oncology Grp Study TI Racial disparities in recurrence among patients with early-stage endometrial cancer - Is recurrence increased in black patients who receive estrogen replacement therapy? SO CANCER LA English DT Article DE race; gynecologic; malignancies; outcome ID GYNECOLOGIC-ONCOLOGY-GROUP; AFRICAN-AMERICAN; WOMEN; ADENOCARCINOMA; CARCINOMA; SURVIVAL; OVEREXPRESSION; IMPACT; ESTRADIOL; CORPUS AB BACKGROUND. Population-based studies suggest that, because of inequalities in treatment, black women with localized endometrial cancer have shorter survival compared with white women. The objective of the current investigation was to determine whether there is a racial disparity in outcome between black patients and white patients with early-stage endometrial cancer treated similarly in a clinical trial setting. METHODS. A retrospective review of 110 black patients and 10,49 white patients with stage I and II endometrial cancer (graded according to the International Federation of Gynecology and Obstetrics grading system) was performed using data from a randomized, placebo-controlled trial performed by the Gynecologic Oncology Group that evaluated postoperative estrogen replacement therapy (ERT) and the risk of cancer recurrence. Demographic, pathologic, treatment, and outcome-related data were collected and analyzed using regression and survival analysis. RESULTS. Estimates of recurrence-free survival suggested that black patients may be more likely to have disease recurrence, particularly those receiving EWE Within a median follow-tip of 3 years, 5 of 56 black patients with endometrial cancer in the ERT group were identified with recurrent disease compared with only 8 of 521 white patients. Adjusted for age, body mass index, and tumor grade, the relative risk of recurrence among blacks in the ERT group was 11.2 (95% confidence interval, 2.86-43.59; P =.0005). CONCLUSIONS. The findings of the current study suggested that recurrence-free survival may be shorter among black women with stage I endometrial cancer, even in a clinical trials setting in which patients receive similar treatment and follow-up. This increased risk of recurrence appeared to be most evident in black women with endometrial cancer who maintained ERT after primary treatment. C1 [Maxwell, G. Larry] Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. [Maxwell, G. Larry; Hamilton, Chad A.] Walter Reed Army Med Ctr, Gynecol Dis Ctr, Div Gynecol Oncol, Washington, DC 20307 USA. [Tian, Chunqiao] Roswell Pk Canc Inst, Stat & Data Ctr, Gynecol Oncol Grp, Buffalo, NY 14263 USA. [Risinger, John I.] Curtis & Elizabeth Anderson Canc Inst, Dept Lab Oncol Res, Savannah, GA USA. [Barakat, Richard R.] Mem Sloan Kettering Canc Ctr, Dept Gynecol Surg, New York, NY 10021 USA. RP Maxwell, GL (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. EM george.maxwell@na.amedd.army.mi FU National Cancer Institute [CA 27469]; Gynecologic Oncology Group Statistical and Data Center [CA 37517] FX Supported by National Cancer Institute grants to the Gynecologic Oncology Group Administrative Office (CA 27469) and the Gynecologic Oncology Group Statistical and Data Center (CA 37517). NR 29 TC 16 Z9 16 U1 0 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD SEP 15 PY 2008 VL 113 IS 6 BP 1431 EP 1437 DI 10.1002/cncr.23717 PG 7 WC Oncology SC Oncology GA 346YP UT WOS:000259105800022 PM 18698590 ER PT J AU Pavlin, JA Hickey, AC Ulbrandt, N Chan, YP Endy, TP Boukhvalova, MS Chunsuttiwat, S Nisalak, A Libraty, DH Green, S Rothman, AL Ennis, FA Jarman, R Gibbons, RV Broder, CC AF Pavlin, Julie A. Hickey, Andrew C. Ulbrandt, Nancy Chan, Yee-Peng Endy, Timothy P. Boukhvalova, Marina S. Chunsuttiwat, Supamit Nisalak, Ananda Libraty, Daniel H. Green, Sharone Rothman, Alan L. Ennis, Francis A. Jarman, Richard Gibbons, Robert V. Broder, Christopher C. TI Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 45th Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT, 2007 CL San Diego, CA SP Infect Dis Soc Amer ID RESPIRATORY-SYNCYTIAL-VIRUS; LINKED-IMMUNOSORBENT-ASSAY; PRIMARY-SCHOOL CHILDREN; YOUNG-CHILDREN; TRACT INFECTIONS; KAMPHAENG PHET; ANTIBODIES; DISEASE; HMPV; SEROPREVALENCE AB Background. Human metapneumovirus (hMPV) is a newly discovered paramyxovirus that causes acute respiratory illness. Despite apparent near-universal exposure during early childhood, immunity is transient. Methods. An indirect screening enzyme-linked immunosorbent assay using a recombinant soluble fusion (F) glycoprotein derived from hMPV was used to test for anti-F IgG in 1380 pairs of acute-and convalescent-stage serum samples collected from children in Kamphaeng Phet, Thailand. Results. Of the 1380 serum sample pairs tested, 1376 (99.7%) showed evidence of prior infection with hMPV. Sixty-six paired specimens demonstrated a >= 4-fold rise in titer, for an overall reinfection rate of 4.9%. Two children demonstrated evidence of an initial infection. Forty-eight of the 68 new infections or reinfections occurred in 2000, accounting for 13.2% of all nonflaviviral febrile illnesses in the study population in that year. Of 68 positive cases, 85.3% complained of cough and 66.2% complained of rhinorrhea, compared with 61.4% and 49.0% of negative cases, respectively (P < .01). All positive samples were also tested for an increase in titer of antibodies to respiratory syncytial virus F, and 27% exhibited a >= 4-fold rise. Conclusion. These results demonstrate that hMPV reinfections cause illness at a rate equal to that seen for initial infections. hMPV may have a more significant impact in older children than previously realized and may be the cause of significant outbreaks in this population. C1 [Pavlin, Julie A.; Hickey, Andrew C.; Chan, Yee-Peng; Broder, Christopher C.] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA. [Ulbrandt, Nancy] Medimmune Inc, Gaithersburg, MD 20878 USA. [Boukhvalova, Marina S.] Virion Syst Inc, Rockville, MD USA. [Endy, Timothy P.] SUNY Upstate Med Univ, Syracuse, NY USA. [Libraty, Daniel H.; Green, Sharone; Rothman, Alan L.; Ennis, Francis A.] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vaccine Res, Worcester, MA USA. [Chunsuttiwat, Supamit] Minist Publ Hlth, Bangkok, Thailand. [Nisalak, Ananda; Jarman, Richard; Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Pavlin, JA (reprint author), USAMC AFRIMS, APO, AP 96456 USA. EM julie.pavlin@afrims.org FU NIAID NIH HHS [P01 AI034533, AI34533, P01 AI034533-15A1] NR 40 TC 25 Z9 26 U1 0 U2 2 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP 15 PY 2008 VL 198 IS 6 BP 836 EP 842 DI 10.1086/591186 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 340RA UT WOS:000258661500007 PM 18680407 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI American rifle: a biography SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 15 PY 2008 VL 133 IS 15 BP 72 EP 72 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 352SP UT WOS:000259518000157 ER PT J AU Wei, Q Kecskes, LJ AF Wei, Q. Kecskes, L. J. TI Effect of low-temperature rolling on the tensile behavior of commercially pure tungsten SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE rolling; tungsten; tensile testing; ductility; strain-rate sensitivity; activation volume ID DUCTILE-BRITTLE TRANSITION; STRAIN-RATE SENSITIVITY; ULTRAFINE GRAIN SIZES; MECHANICAL-PROPERTIES; POLYCRYSTALLINE TUNGSTEN; PLASTIC-DEFORMATION; ACTIVATION VOLUME; BCC METALS; NANOCRYSTALLINE; COMPRESSION AB We have evaluated the tensile behavior of commercially pure tungsten (W) as a function of low-temperal ire rolling. It is observed that rolling below the nominal recrystallization temperature 1523 K (1250 degrees C) concomitantly enhances the ductility am strength of W. Strain-rate jump tests and stress-relaxation experiments show that low-temperature rolling also renders reduced strain-rate sensitivity and activation volumes associated with the plastic deformation of W. For W samples rolled at 873 K (600 degrees C), with a total equivalent strain of similar to 2.5 (including a previous rolling strain of 1.7 introduced at 1073 K [800 degrees C]), the activation volume for plastic deformation is around 10b(3) (b is the magnitude of the Burgers vector of W). This is in agreement with a double-kink mechanism with the spreading between the kinks control led by the forest dislocation density. Fractographic observations indicate that the rolled W exhibits a laminar structure. The layer thickness is a function of rolling temperature, rather than a function of rolling strain introduced. (C) 2008 Elsevier B.V. All rights reserved. C1 [Wei, Q.] Univ N Carolina, Dept Mech Engn & Engn Sci, Charlotte, NC 28223 USA. [Wei, Q.] Johns Hopkins Univ, Ctr Adv Ceram & Met Syst, Baltimore, MD 21218 USA. [Kecskes, L. J.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn & Engn Sci, 9201 Univ City Blvd, Charlotte, NC 28223 USA. EM qwei@uncc.edu RI Wei, Qiuming/B-7579-2008; Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 31 TC 43 Z9 44 U1 6 U2 29 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD SEP 15 PY 2008 VL 491 IS 1-2 BP 62 EP 69 DI 10.1016/j.msea.2008.01.013 PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 334QR UT WOS:000258236800008 ER PT J AU Grujicic, M Pandurangan, B Coutris, N Cheeseman, BA Fountzoulas, C Patel, P Strassburger, E AF Grujicic, M. Pandurangan, B. Coutris, N. Cheeseman, B. A. Fountzoulas, C. Patel, P. Strassburger, Elmar TI A ballistic material model for starphire (R), a soda-lime transparent-armor glass SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE transparent-armor; glass; material modeling; ballistic performance; Starphire (R) ID FRACTURE AB Experimental observations pertaining to the damage evolution in Starphire (R), a soda-lime transparent-armor glass, made in the recent work of Strassburger et al. [E. Strassburger, P. Patel, J.W. McCauley, C. Kovalchick, K.T. Ramesh, D.W. Templeton, Proceedings of the 23rd International Symposium on Ballistics, Spain, April, 2007; E. Strassburger, P. Patel, J.W. McCauley, D.W. Templeton, Proceedings of the 23rd International Symposium on Ballistics, Spain, April, 20071 in a series of edge-on-impact (EOI) tests and other open literature experimental findings are used to construct a (high strain-rate, high-pressure, large-strain) ballistic constitutive model for this material. The basic components of the model are constructed in such a way that the model is suitable for direct incorporation into typical transient non-linear dynamics finite element-based software packages like ANSYS/Autodyn [ANSYS/Autodyn version 11.0, User Documentation, Century Dynamics Inc. a subsidiary of ANSYS Inc., 2007] or ABAQUS/Explicit[ABAQUS version 6.7, User Documentation, Dessault Systems, 2007]. To validate the material model, a set of finite element analyses of EOI tests was carried out and the computational results compared with their experimental counterparts. It is found that front-shapes and propagation velocities of the longitudinal and transverse waves are quite well represented by the model. The same was found to be the case for front-shapes and propagation velocities of the "coherent-damage" zones but mainly at shorter post-impact times. Discrepancies at longer post-impact times are attributed to the effects of damage-promoting target-fixturing-induced stresses and cutting/grinding-induced flaws. (c) 2008 Elsevier B.V. All rights reserved. C1 [Grujicic, M.; Pandurangan, B.; Coutris, N.] Clemson Univ, Dept Mech Engn, CU ICAR, Clemson, SC 29634 USA. [Cheeseman, B. A.; Fountzoulas, C.; Patel, P.] Survivabil Mat Branch, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Strassburger, Elmar] Fraunhofer Ernst Mach Inst, Efringen Kirchen, Germany. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, CU ICAR, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu NR 15 TC 17 Z9 18 U1 1 U2 11 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD SEP 15 PY 2008 VL 491 IS 1-2 BP 397 EP 411 DI 10.1016/j.msea.2008.02.020 PG 15 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 334QR UT WOS:000258236800053 ER PT J AU Tunick, A AF Tunick, Arnold TI Optical turbulence parameters characterized via optical measurements over a 2.33 km free-space laser path SO OPTICS EXPRESS LA English DT Article ID ATMOSPHERIC-TURBULENCE; BEAM; SCINTILLATION; INTENSITY; C-N(2) AB Optical turbulence research contributes to improved laser communications, adaptive optics, and long-range imaging systems. This paper presents experimental measurements of scintillation and focal spot displacement to obtain optical turbulence information along a near-horizontal 2.33 km free-space laser propagation path. Calculated values for the refractive index structure constant (C-n(2)) and Fried parameter (r(0)) are compared to scintillometer-based measurements for several cases in winter and spring. Optical measurements were investigated using two different laser sources for the first and second parts of the experiment. Scintillation index estimates from recorded signal intensities were corrected to account for aperture averaging. As a result, we found that an earlier calculation algorithm based on analysis of log-amplitude intensity variance was the best estimator of optical turbulence parameters over the propagation path considered. (C) 2008 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. RP Tunick, A (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM atunick@arl.army.mil NR 21 TC 13 Z9 14 U1 0 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 15 PY 2008 VL 16 IS 19 BP 14645 EP 14654 DI 10.1364/OE.16.014645 PG 10 WC Optics SC Optics GA 349HM UT WOS:000259271900036 PM 18795001 ER PT J AU Kim, JH Chen, MK Yang, CE Lee, J Shi, KB Liu, ZW Yin, S Reichard, K Ruffin, P Edwards, E Brantley, C Luo, C AF Kim, Jae Hun Chen, Meng-Ku Yang, Chia-En Lee, Jon Shi, Kebin Liu, Zhiwen (Shizhuo) Yin, Stuart Reichard, Karl Ruffin, Paul Edwards, Eugene Brantley, Christina Luo, Claire TI Broadband supercontinuum generation covering UV to mid-IR region by using three pumping sources in single crystal sapphire fiber SO OPTICS EXPRESS LA English DT Article ID MICROSTRUCTURED OPTICAL-FIBERS; MU-M; ABSORPTION-SPECTROSCOPY; CONTINUUM GENERATION; RAMAN-SCATTERING; DISPERSION; LASER; PULSES; LIGHT; AMPLIFIER AB In this paper, we demonstrate that the the bandwidth of the supercontinuum spectrum generated in a large mode area sapphire fiber can be enhanced by employing triple pumping sources. Three pumping sources with wavelengths of 784nm, 1290nm, and 2000nm are launched into a single crystal sapphire fiber that is 5cm in length and has a core diameter of 115 mu m. The nonlinear interactions due to self-phase modulation and four-wave mixing form a broadband supercontinuum that covers the UV, visible, near-IR and lower mid-IR regions. Furthermore, we explore the possibility of generating a broadband supercontinuum expanding from the UV to far-IR region by increasing the number of pumping sources with wavelengths in the mid- and far-IR. (C) 2008 Optical Society of America. C1 [Kim, Jae Hun; Chen, Meng-Ku; Yang, Chia-En; Lee, Jon; Shi, Kebin; Liu, Zhiwen; (Shizhuo) Yin, Stuart] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. [Reichard, Karl] Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. [Ruffin, Paul; Edwards, Eugene; Brantley, Christina] USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. [Luo, Claire] Gen Opto Solut LLC, State Coll, PA 16803 USA. RP Yin, S (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA. EM sxy105@psu.edu RI Shi, Kebin/D-3656-2009; OI Kim, Jae-Hun/0000-0001-6537-0350 FU ONR [N00014-05-1-0844] FX Partial financial support of this work by ONR grant, N00014-05-1-0844 is greatly appreciated. NR 42 TC 15 Z9 15 U1 0 U2 13 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 15 PY 2008 VL 16 IS 19 BP 14792 EP 14800 DI 10.1364/OE.16.014792 PG 9 WC Optics SC Optics GA 349HM UT WOS:000259271900051 PM 18795016 ER PT J AU Chen, G Abou-Galala, F Xu, ZY Sadler, BM AF Chen, Gang Abou-Galala, Feras Xu, Zhengyuan Sadler, Brian M. TI Experimental evaluation of LED-based solar blind NLOS communication links SO OPTICS EXPRESS LA English DT Article ID LIGHT-EMITTING-DIODES; 4H-SIC AVALANCHE PHOTODIODES; ULTRAVIOLET COMMUNICATION; TEST-BED; SYSTEM; PERFORMANCE AB Experimental results are reported demonstrating non-line of sight short-range ultraviolet communication link losses, and performance of photon counting detectors, operating in the solar blind spectrum regime. We employ light emitting diodes with divergent beams, a solar blind filter, and a wide field-of-view detector. Signal and noise statistics are characterized, and receiver performance is demonstrated. The effects of transmitter and receiver elevation angles, separation distance, and path loss are included. (C) 2008 Optical Society of America. C1 [Chen, Gang; Abou-Galala, Feras; Xu, Zhengyuan] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. [Sadler, Brian M.] USA, Res Lab, AMSRD ARL CI NT, Adelphi, MD 20783 USA. RP Xu, ZY (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA. EM dxu@ee.ucr.edu FU Army Research Office [W911NF-06-1-0364, W911NF-06-1-0173]; Army Research Laboratory under the Collaborative Technology Alliance Program [DAAD19-01-2-0011] FX The authors would like to thank Haipeng Ding and Qunfeng He for their invaluable help with experiments. This work was supported in part by the Army Research Office under Grants W911NF-06-1-0364 and W911NF-06-1-0173, and the Army Research Laboratory under the Collaborative Technology Alliance Program, Cooperative Agreement DAAD19-01-2-0011. NR 35 TC 71 Z9 78 U1 1 U2 9 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 15 PY 2008 VL 16 IS 19 BP 15059 EP 15068 DI 10.1364/OE.16.015059 PG 10 WC Optics SC Optics GA 349HM UT WOS:000259271900078 PM 18795043 ER PT J AU Suedel, BC Kim, J Clarke, DG Linkov, I AF Suedel, Burton C. Kim, Jongbum Clarke, Douglas G. Linkov, Igor TI A risk-informed decision framework for setting environmental windows for dredging projects SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE sediment; dredging; environmental window; multi-criteria decision analysis; risk assessment ID MULTICRITERIA ACCEPTABILITY ANALYSIS; SEDIMENTS AB Sediment dredging is necessary to sustain navigation infrastructure in ports and harbor areas. In the United States alone between 250 and 300 million cubic yards of sediment are dredged annually. Dredging activities may cause stress on aquatic biota by locally increasing turbidity and suspended sediment concentrations, physically disturbing habitat by elevated sedimentation rates, interfering in migratory behaviors, and hydraulically entraining bottom dwelling organisms. Environmental windows are a management practice used to alleviate such stresses on resident and transient biota by placing temporal restrictions on the conduct of dredging operations. Adherence to environmental windows can significantly inflate costs for project sponsors and local stakeholders. Since their inception following passage of NEPA in 1969 the process for setting environmental windows has not followed structured procedures and represents an example of the difficulty inherent in achieving a balance between biological resource protection and cost-effective construction and maintenance of navigation infrastructure. Recent developments in the fields of risk assessment for non-chemical stressors as well as experience in implementing structured risk-informed decision-making tools for sediment and natural resource management are summarized in this paper in relation to setting environmental windows. Combining risk assessment and multi-criteria decision analysis allows development of a framework for an objective process consistent with recommendations by the National Academy of Sciences for setting environmental windows. A hypothetical application of the framework for protection of Pacific herring (Clupea pallasii) in San Francisco Bay is discussed. (C) 2008 Elsevier B.V. All rights reserved. C1 [Suedel, Burton C.; Kim, Jongbum; Clarke, Douglas G.; Linkov, Igor] USA, Corps Engineers, Engineers Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. RP Kim, J (reprint author), USA, Corps Engineers, Engineers Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM jongbum.kim@erdc.usace.army.mil FU Dredging Operations and Environmental Research (DOER) FX We would like to thank Jose Rui Figueira and Tommi Tervonen for allowing the use of SMAA software for this project and useful discussions. Funding was provided by the Dredging Operations and Environmental Research (DOER) Program. Permission was granted by the USACE Chief of Engineers to publish this material. NR 28 TC 19 Z9 20 U1 0 U2 15 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0048-9697 J9 SCI TOTAL ENVIRON JI Sci. Total Environ. PD SEP 15 PY 2008 VL 403 IS 1-3 BP 1 EP 11 DI 10.1016/j.scitotenv.2008.04.055 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 352ZW UT WOS:000259536900001 PM 18571217 ER PT J AU Chilukuri, N Sun, W Parikh, K Naik, RS Tang, L Doctor, BP Saxena, A AF Chilukuri, Nageswararao Sun, Wei Parikh, Kalpana Naik, Ramachandra S. Tang, Lin Doctor, Bhupendra P. Saxena, Ashima TI A repeated injection of polyethyleneglycol-conjugated recombinant human butyrylcholinesterase elicits immune response in mice SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE recombinant human butyrylcholinesterase; PEG conjugation; circulatory stability; immunogenicity; organophosphorus compounds; bioscavengers ID HAMSTER OVARY CELLS; HALF-LIFE; COVALENT ATTACHMENT; ACETYLCHOLINESTERASE; TOXICITY; PROTECTION; GLYCOL; SOMAN; CHOLINESTERASE; IMMUNOGENICITY AB Human serum butyrylcholinesterase (Hu BChE) serves as an efficacious bioscavenger of highly toxic organophosphorus (OP) compounds. Since there is a concern that the Supply of native Hu BChE may be limited, monomeric and tetrameric forms of recombinant Hu BChE (rHu BChE) were evaluated as replacements and found that they lacked sufficient stability in vivo. However, their in vivo stability could be significantly prolonged by conjugation with polyethyleneglycol-20K (PEG) suggesting that monomeric and tetrameric PEG-rHu BChE could function as bioscavengers. Here, the immunogenicity of PEG-rHu BChE was evaluated in mice following two injections given four weeks apart. In addition to pharmacokinetic parameters, such as mean residence time, maximal concentration, time to reach the maximal concentration, elimination half-life and area under the plasma concentration-time curve extrapolated to infinity, the presence of circulating anti-rHu BChE antibodies was also determined. Although the pharmacokinetic parameters were significantly improved for the first injection of monomeric and tetrameric PEG-rHu BChEs, they were much lower for the second injection. Anti-rHu BChE antibodies were detected in the blood of mice following the first and second enzyme injections and their levels were approximately higher by 5-fold and 2-fold in mice injected with monomeric and tetrameric PEG-rHu BChEs as compared to mice injected with unconjugated enzymes. The findings that the rapid clearance of a repeat injection of PEG-rHu BChEs in mice which coincides with the presence of circulating anti-rHu BChE antibodies suggest that PEG conjugation prolonged the circulatory stability of rHu BChE but failed to eliminate its immunogenicity in mice. Published by Elsevier Inc. C1 [Chilukuri, Nageswararao; Sun, Wei; Parikh, Kalpana; Naik, Ramachandra S.; Tang, Lin; Doctor, Bhupendra P.; Saxena, Ashima] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. RP Chilukuri, N (reprint author), Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. EM Nageswararao.chilukuri@us.army.mil FU Defense Threat Reduction Agency (DTRA), Department of Defense FX This work was supported by a grant from Defense Threat Reduction Agency (DTRA), Department of Defense. NR 42 TC 6 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD SEP 15 PY 2008 VL 231 IS 3 BP 423 EP 429 DI 10.1016/j.taap.2008.05.016 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 353AG UT WOS:000259537900017 PM 18586293 ER PT J AU Centini, M Roppo, V Fazio, E Pettazzi, F Sibilia, C Haus, JW Foreman, JV Akozbek, N Bloemer, MJ Scalora, M AF Centini, Marco Roppo, Vito Fazio, Eugenio Pettazzi, Federico Sibilia, Concita Haus, Joseph W. Foreman, John V. Akozbek, Neset Bloemer, Mark J. Scalora, Michael TI Inhibition of linear absorption in opaque materials using phase-locked harmonic generation SO PHYSICAL REVIEW LETTERS LA English DT Article ID 2ND-HARMONIC GENERATION; 3RD-HARMONIC GENERATION; OPTICAL HARMONICS; ABSORBING MEDIA; LIGHT WAVES; DISPERSION; PULSES; MODULATION; CRYSTALS; VELOCITY AB We theoretically predict and experimentally demonstrate inhibition of linear absorption for phase and group velocity mismatched second- and third-harmonic generation in strongly absorbing materials, GaAs, in particular, at frequencies above the absorption edge. A 100-fs pump pulse tuned to 1300 nm generates 650 and 435 nm second- and third-harmonic pulses that propagate across a 450-mu m-thick GaAs substrate without being absorbed. We attribute this to a phase-locking mechanism that causes the pump to trap the harmonics and to impress on them its dispersive properties. C1 [Centini, Marco; Fazio, Eugenio; Pettazzi, Federico; Sibilia, Concita] Univ Roma La Sapienza, Dipartimento Energet, Rome, Italy. [Roppo, Vito] Univ Politecn Cataluna, Dept Fis & Engn Nucl, Terrassa 08222, Spain. [Haus, Joseph W.] Univ Dayton, Electroopt Program, Dayton, OH 45469 USA. [Roppo, Vito; Foreman, John V.; Akozbek, Neset; Bloemer, Mark J.; Scalora, Michael] USA, Aviat & Missile Command, Charles M Bowden Res Facil, Redstone Arsenal, AL 35803 USA. [Foreman, John V.] Duke Univ, Dept Phys, Durham, NC 27708 USA. RP Centini, M (reprint author), Univ Roma La Sapienza, Dipartimento Energet, Rome, Italy. RI roppo, vito/D-9639-2012; OI roppo, vito/0000-0003-0928-4209; FAZIO, Eugenio/0000-0002-0995-0702; CENTINI, MARCO/0000-0003-0625-0054 NR 25 TC 32 Z9 32 U1 1 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 12 PY 2008 VL 101 IS 11 AR 113905 DI 10.1103/PhysRevLett.101.113905 PG 4 WC Physics, Multidisciplinary SC Physics GA 348CN UT WOS:000259188700019 PM 18851284 ER PT J AU Podeszwa, R Rice, BM Szalewicz, K AF Podeszwa, Rafal Rice, Betsy M. Szalewicz, Krzysztof TI Predicting structure of molecular crystals from first principles SO PHYSICAL REVIEW LETTERS LA English DT Article ID POTENTIAL-ENERGY SURFACE; CYCLOTRIMETHYLENE-TRINITRAMINE; PERTURBATION-THEORY; BENZENE CRYSTAL; BLIND TEST; DIMER; SUBLIMATION; MONOMERS; HEAT AB A recently developed method, symmetry-adapted perturbation theory based on the density-functional description of monomers [SAPT(DFT)], is shown to be sufficiently accurate and numerically efficient to facilitate predictions of the structure of molecular crystals from first principles. In one application, a SAPT(DFT) potential was used to generate and order polymorphs of the cyclotrimethylene trinitramine crystal, resulting in the lowest-energy structure in excellent agreement with the experimental crystal. In a different application, a SAPT(DFT)-based calculation reproduced the lattice energy of the benzene crystal to within a few percent. C1 [Podeszwa, Rafal] Univ Warsaw, Fac Chem, PL-02093 Warsaw, Poland. [Podeszwa, Rafal; Szalewicz, Krzysztof] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA. [Rice, Betsy M.] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Podeszwa, R (reprint author), Univ Warsaw, Fac Chem, Pasteura 1, PL-02093 Warsaw, Poland. FU ARO DEPSCOR; ONR; NSF [CHE-0555979]; Polish Science Foundation; DoD HPCMP FX This research was supported by an ARO DEPSCOR grant, by ONR, by NSF Grant No. CHE-0555979, by the Polish Science Foundation grant Homing, and by a DoD HPCMP Challenge Project. NR 33 TC 90 Z9 92 U1 0 U2 42 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD SEP 12 PY 2008 VL 101 IS 11 AR 115503 DI 10.1103/PhysRevLett.101.115503 PG 4 WC Physics, Multidisciplinary SC Physics GA 348CN UT WOS:000259188700030 PM 18851295 ER PT J AU Sun, C Dobi, A Mohamed, A Li, H Thangapazham, RL Furusato, B Shaheduzzaman, S Tan, SH Vaidyanathan, G Whitman, E Hawksworth, DJ Chen, Y Nau, M Patel, V Vahey, M Gutkind, JS Sreenath, T Petrovics, G Sesterhenn, IA McLeod, DG Srivastava, S AF Sun, C. Dobi, A. Mohamed, A. Li, H. Thangapazham, R. L. Furusato, B. Shaheduzzaman, S. Tan, S-H Vaidyanathan, G. Whitman, E. Hawksworth, D. J. Chen, Y. Nau, M. Patel, V. Vahey, M. Gutkind, J. S. Sreenath, T. Petrovics, G. Sesterhenn, I. A. McLeod, D. G. Srivastava, S. TI TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation SO ONCOGENE LA English DT Article DE ERG; prostate cancer; oncogene; C-MYC; PSA; TMPRSS2-ERG ID ETS TRANSCRIPTION FACTOR; ANDROGEN RECEPTOR; EXPRESSION; REARRANGEMENTS; LEUKEMIA; TARGETS; ADULTS; GENES; ERG AB The high prevalence of TMPRSS2-ERG rearrangements (similar to 60%) in prostate cancer (CaP) leads to androgenic induction of the ETS-related gene (ERG) expression. However, the biological functions of ERG overexpression in CaP remain to be understood. ERG knockdown in TMPRSS2-ERG expressing CaP cells induced striking morphological changes and inhibited cell growth both in cell culture and SCID mice. Evaluation of the transcriptome and specific gene promoters in ERG siRNA-treated cells and investigation of gene expression signatures of human prostate tumors revealed ERG-mediated activation of C-MYC oncogene and the repression of prostate epithelial differentiation genes (PSA and SLC45A3/Prostein). Taken together, these data combining cell culture and animal models and human prostate tumors reveal that ERG overexpression in prostate tumor cells may contribute to the neoplastic process by activating C-MYC and by abrogating prostate epithelial differentiation as indicated by prostate epithelial specific markers. C1 [Sun, C.; Dobi, A.; Mohamed, A.; Li, H.; Thangapazham, R. L.; Furusato, B.; Shaheduzzaman, S.; Tan, S-H; Vaidyanathan, G.; Whitman, E.; Hawksworth, D. J.; Chen, Y.; Sreenath, T.; Petrovics, G.; McLeod, D. G.; Srivastava, S.] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Rockville, MD 20852 USA. [Furusato, B.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Whitman, E.; Hawksworth, D. J.; McLeod, D. G.] Walter Reed Army Med Ctr, Urol Serv, Dept Surg, Washington, DC 20307 USA. [Nau, M.; Vahey, M.] Walter Reed Army Inst Res, Div Retrovirol, Rockville, MD USA. [Patel, V.; Gutkind, J. S.] Natl Inst Dent & Craniofacial Res, Oral & Pharyngeal Canc Branch, Natl Inst Hlth, Bethesda, MD USA. [Dobi, A.; Sesterhenn, I. A.; McLeod, D. G.; Srivastava, S.] US Mil Canc Inst, Washington, DC USA. RP Srivastava, S (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, 1530 E Jefferson St, Rockville, MD 20852 USA. EM ssrivastava@cpdr.org RI Gutkind, J. Silvio/A-1053-2009; OI Furusato, Bungo/0000-0003-4614-9882 FU US Army Medical Research and Materiel Command; NIH Grants [RO1 DK065977, RO1 CA106653] FX Authors express sincere thanks to Ms Lakshmi Ravindranath, Ms Atekelt Y Tadese, Ms Suma Ravulapalli and Mr Christopher Cook for their superb technical support of this study. The prostate tissue specimens used in this study were obtained under an IRB-approved protocol at Walter Reed Army Medical Center. This work was funded by the CPDR through an ongoing grant from the US Army Medical Research and Materiel Command, NIH Grants RO1 DK065977 to S. S and G. P. and RO1 CA106653 to S. S. and A. D. The views expressed in this manuscript are those of the authors and do not reflect the official policy of the Department of the Army, Department of Defense or the US Government. NR 22 TC 121 Z9 122 U1 0 U2 8 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0950-9232 J9 ONCOGENE JI Oncogene PD SEP 11 PY 2008 VL 27 IS 40 BP 5348 EP 5353 DI 10.1038/onc.2008.183 PG 6 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA 346UW UT WOS:000259096100007 PM 18542058 ER PT J AU Legler, PM Kumaran, D Swaminathan, S Studier, FW Millard, CB AF Legler, Patricia M. Kumaran, Desigan Swaminathan, Subramanyam Studier, F. William Millard, Charles B. TI Structural characterization and reversal of the natural organophosphate resistance of a D-type esterase, Saccharomyces cerevisiae S-formylglutathione hydrolase SO BIOCHEMISTRY LA English DT Article ID AMINO-ACID SUBSTITUTION; HUMAN BUTYRYLCHOLINESTERASE; SPONTANEOUS REACTIVATION; CRYSTAL-STRUCTURE; REDOX REGULATION; SULFENIC ACID; ACTIVE-SITE; ACETYLCHOLINESTERASE; PURIFICATION; SERUM AB Saccharomyces cerevisiae expresses a 67.8 kDa homodimeric serine thioesterase, S-formylglutathione hydrolase (SFGH), that is 39.9% identical with human esterase D. Both enzymes possess significant carboxylesterase and S-formylglutathione thioesterase activity but are unusually resistant to organophosphate (OP) inhibitors. We determined the X-ray crystal structure of yeast (y) SFGH to 2.3 angstrom resolution by multiwavelength anomalous dispersion and used the structure to guide site-specific mutagenesis experiments addressing substrate and inhibitor reactivity. Our results demonstrate a steric mechanism of OP resistance mediated by a single indole ring (W 197) located in an enzyme "acyl pocket". The W197I substitution enhances ySFGH reactivity with paraoxon by >1000-fold (k(i)(W1911) = 16 +/- 2 mM(-1) h(-1)), thereby overcoming natural OP resistance. W197I increases the rate of OP inhibition under pseudo-first-order conditions but does not accelerate OP hydrolysis. The structure of the paraoxon-inhibited W 1971 variant was determined by molecular replacement (2.2 A); it revealed a stabilized sulfenic acid at Cys60. Wild-type (WT) ySFGH is inhibited by thiol reactive compounds and is sensitive to oxidation; thus, the cysteine sulfenic acid may play a role in the regulation of a "D-type" esterase. The structure of the W197I variant is the first reported cysteine sulfenic acid in a serine esterase. We constructed five Cys60/WI971 variants and show that introducing a positive charge near the oxyanion hole, W197I/C60R or W1971/C60K, results in a further enhancement of the rates of phosphorylation with paraoxon (k(i) = 42 or 80 mM(-1) h(-1), respectively) but does not affect the dephosphorylation of the enzyme. We also characterized three histidine substitutions near the oxyanion hole, G57H, L58H, and M162H, which significantly decrease esterase activity. C1 [Legler, Patricia M.; Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA. [Kumaran, Desigan; Swaminathan, Subramanyam; Studier, F. William] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. RP Millard, CB (reprint author), Walter Reed Army Inst Res, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM charles.b.millard@us.army.mil FU U.S. Defense Threat Reduction Agency JSTO Award [1.DO015_06_WR_C]; National Institutes of Health; New York Structural Genomics Research Consortium; Office of Biological and Environmental Research of the U.S. Department of Energy FX This work was funded by the U.S. Defense Threat Reduction Agency JSTO Award 1.DO015_06_WR_C (C.B.M.), by the Protein Structure Initiative of the National Institutes of Health as part of the New York Structural Genomics Research Consortium, and by the Office of Biological and Environmental Research of the U.S. Department of Energy. NR 47 TC 15 Z9 15 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 EI 1943-295X J9 BIOCHEMISTRY-US JI Biochemistry PD SEP 9 PY 2008 VL 47 IS 36 BP 9592 EP 9601 DI 10.1021/bi8010016 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 343PT UT WOS:000258866700025 PM 18707125 ER PT J AU Johnson, KP Blum, JD Keeler, GJ Douglas, TA AF Johnson, Kelsey P. Blum, Joel D. Keeler, Gerald J. Douglas, Thomas A. TI Investigation of the deposition and emission of mercury in arctic snow during an atmospheric mercury depletion event SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SPRINGTIME DEPLETION; GASEOUS MERCURY; POLAR SUNRISE; NY-ALESUND; OZONE; AIR; SVALBARD; CANADA; KUUJJUARAPIK; CHEMISTRY AB Mechanisms of air-snow exchange of mercury (Hg) during and after atmospheric mercury depletion events (AMDEs) remain poorly constrained and this has limited our understanding of the arctic Hg cycle. We measured the Hg concentrations of surface snow through time and carried out flux chamber experiments during AMDE and non-AMDE conditions in the spring of 2006 near Barrow, Alaska. Clear skies, low-velocity onshore winds, and a stable boundary layer characterized the meteorology during this AMDE. Surface snow Hg concentrations (upper 1 cm) increased throughout a 9-day AMDE from background levels (4.1-15.5 ng/L) to elevated levels (147 and 237 ng/L) at two sampling sites and returned to near-baseline values within 2 days of AMDE cessation. The Hg concentrations of core samples from the full snowpack did not increase significantly during the AMDE and demonstrate that the Hg enhancement of surface snow resulted from deposition of atmospheric Hg to surface snow. We estimate that complete deposition of background Hg to a height of 200-450 m in the near-surface troposphere could account for the Hg gains to surface snow during this event. Snow incubated in field-based flux chambers emitted 4 to 7% of its total Hg content within 1 day and may represent an upper limit for the photo-reduction rate of "easily'' reducible Hg in snow under post-AMDE conditions. Full-column snow core samples collected in the late springtime have comparable Hg loads to those observed during the AMDE season and imply that a significant fraction of the Hg deposited during the 3-month AMDE season was retained until snowmelt at this location. C1 [Johnson, Kelsey P.; Blum, Joel D.] Univ Michigan, Dept Geol Sci, Ann Arbor, MI 48109 USA. [Douglas, Thomas A.] USA, Cold Reg Res & Engn Lab, Biogeochem Sci Branch, Ft Wainwright, AK USA. [Keeler, Gerald J.] Univ Michigan, Air Qual Lab, Ann Arbor, MI 48109 USA. RP Johnson, KP (reprint author), Univ Michigan, Dept Geol Sci, 1100 N Univ Ave, Ann Arbor, MI 48109 USA. EM kelseyjo@umich.edu; jdblum@umich.edu; jkeeler@umich.edu; thomas.a.douglas@usace.army.mil FU National Science Foundation Office of Polar Programs [ARC-0435989, ARC-0435893] FX This study was funded by the National Science Foundation Office of Polar Programs Grants ARC-0435989 and ARC-0435893. Special thanks to the Barrow Arctic Science Consortium, J. Barres, and UMAQL for technical expertise and J. Bier for field assistance. We thank B. Bergquist, M. Sturm, D. Perovich, W. Simpson, and L. Alvarez-Aviles for helpful discussions and two anonymous reviewers for comments that significantly improved the manuscript. NR 38 TC 26 Z9 27 U1 1 U2 15 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-897X EI 2169-8996 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD SEP 5 PY 2008 VL 113 IS D17 AR D17304 DI 10.1029/2008JD009893 PG 11 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 345MH UT WOS:000259000400006 ER PT J AU Wang, XY Stavchansky, S Zhao, BT Bynum, JA Kerwin, SM Bowman, PD AF Wang, Xinyu Stavchansky, Salomon Zhao, Baiteng Bynum, James A. Kerwin, Sean M. Bowman, Phillip D. TI Cytoprotection of human endothelial cells from menadione cytotoxicity by caffeic acid phenethyl ester: The role of heme oxygenase-1 SO EUROPEAN JOURNAL OF PHARMACOLOGY LA English DT Article DE caffeic acid phenethyl ester; cytoprotection; oxidative stress; human endothelial cell; heme oxygenase-1; gene expression analysis ID ISCHEMIA-REPERFUSION INJURY; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; CARBON-MONOXIDE; MYOCARDIAL ISCHEMIA/REPERFUSION; INFLAMMATORY RESPONSE; SULFHYDRYL-GROUPS; EPITHELIAL-CELLS; ANTIOXIDANT; EXPRESSION AB Caffeic acid phenethyl ester (CAPE), derived from various plant sources, has been shown to ameliorate ischemia/reperfusion injury in vivo, and this has been attributed to its ability to reduce oxidative stress. Here we investigated the cytoprotection of CAPE against menadione-induced oxidative stress in human umbilical vein endothelial cells (HUVEC) to evaluate potential gene expression involvement. CAPE exhibited dose-dependent cytoprotection of HUVEC. A gene screen with microarrays was performed to identify the potential cytoprotective gene(s) induced by CAPE. Heme oxygenase-1 (HO-1) was highly upregulated by CAPE and this was confirmed with reverse transcriptase polymerase chain reaction (RT-PCR) and western blotting. Inhibition of HO-1 activity using the HO-1 inhibitor tin protoporphyrin IX (SnPPIX), resulted in loss of cytoprotection. Carbon monoxide, one of HO-1 catabolic products appeared to play a small role in CAPE protection. Caffeic acid, a potential metabolite of CAPE with similar free radical scavenging ability, however, didn't show any cytoprotective effect nor induce HO-1. These findings suggest an important role of HO-1 induction in CAPE cytoprotection against oxidant stress, which may not relate to CAPE structural antioxidant activity nor to its traditional enzymatic activity in decomposing heme but to a yet to be determined activity. Published by Elsevier B.V. C1 [Wang, Xinyu; Stavchansky, Salomon; Zhao, Baiteng] Univ Texas Austin, Div Pharmaceut, Coll Pharm, Austin, TX 78712 USA. [Wang, Xinyu; Zhao, Baiteng; Bynum, James A.; Bowman, Phillip D.] USA, Inst Surg Res, San Antonio, TX 78234 USA. [Kerwin, Sean M.] Univ Texas Austin, Div Med Chem, Austin, TX 78712 USA. [Kerwin, Sean M.] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA. RP Bowman, PD (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM phillip.bowman@amedd.army.mil OI Kerwin, Sean/0000-0001-8432-6558 NR 55 TC 24 Z9 24 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0014-2999 J9 EUR J PHARMACOL JI Eur. J. Pharmacol. PD SEP 4 PY 2008 VL 591 IS 1-3 BP 28 EP 35 DI 10.1016/j.ejphar.2008.06.017 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA 347SW UT WOS:000259162300005 PM 18573251 ER PT J AU Isayev, O Gorb, L Qasim, M Leszczynski, J AF Isayev, Olexandr Gorb, Leonid Qasim, Mo Leszczynski, Jerzy TI Ab initio molecular dynamics study on the initial chemical events in nitramines: Thermal decomposition of CL-20 SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID REACTIVE FORCE-FIELD; DENSITY-FUNCTIONAL THEORY; PHASE ALPHA-HMX; UNIMOLECULAR DECOMPOSITION; ENERGETIC MATERIALS; HEXANITROHEXAAZAISOWURTZITANE CL-20; EXTREME CONDITIONS; RDX EXPOSURE; MECHANISM; TOXICITY AB CL-20 (2,4,6,8,10,12-hexanitro-214,6,8,10,12-hexaazaisowurtzitane or HNIW) is a high-energy nitramine explosive. To improve atomistic understanding of the thermal decomposition of CL-20 gas and solid phases, we performed a series of A initio molecular dynamics simulations. We found that during unimolecular decomposition, unlike other nitramines (e.g., RDX, HMX), CL-20 has only one distinct initial reaction channel-homolysis of the N-NO2 bond. We did not observe any HONO elimination reaction during unimolecular decomposition, whereas the ring-breaking reaction was followed by NO2 fission. Therefore, in spite of limited sampling, that provides a mostly qualitative picture, we proposed here a scheme of unimolecular decomposition of CL-20. The averaged product population over all trajectories was estimated at four HCN, two to four NO2, two to four NO, one CO, and one OH molecule per one CL-20 molecule. Our simulations provide a detailed description of the chemical processes in the initial stages of thermal decomposition of condensed CL-20, allowing elucidation of key features of such processes as composition of primary reaction products, reaction timing, and Arrhenius behavior of the system. The primary reactions leading to NO2, NO, N2O, and N-2 occur at very early stages. We also estimated potential activation barriers for the formation of NO2, which essentially determines overall decomposition kinetics and effective rate constants for NO2 and N-2. The calculated solid-phase decomposition pathways correlate with available condensed-phase experimental data. C1 [Isayev, Olexandr; Gorb, Leonid; Leszczynski, Jerzy] Jackson State Univ, Computing Ctr Mol Struct & Interact, Jackson, MS 39217 USA. [Gorb, Leonid; Qasim, Mo; Leszczynski, Jerzy] USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Leszczynski, J (reprint author), Jackson State Univ, Computing Ctr Mol Struct & Interact, Jackson, MS 39217 USA. EM jerzy@ccmsi.us RI Isayev, Olexandr/B-7944-2008 OI Isayev, Olexandr/0000-0001-7581-8497 FU U.S. Army Engineer Research and Development Center (ERDC) [W912HZ-05-C-0051]; Army High Performance Computing Research Center (AHPCRC) FX This work was supported by the U.S. Army Engineer Research and Development Center (ERDC) Grant No. W912HZ-05-C-0051 and by the Army High Performance Computing Research Center (AHPCRC). We thank the ERDC and AHPCRC for a generous allotment of computer time. NR 56 TC 32 Z9 38 U1 7 U2 32 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD SEP 4 PY 2008 VL 112 IS 35 BP 11005 EP 11013 DI 10.1021/jp804765m PG 9 WC Chemistry, Physical SC Chemistry GA 342RD UT WOS:000258800300034 PM 18686996 ER PT J AU Meyers, RE Deacon, KS AF Meyers, Ronald E. Deacon, Keith S. TI Lens-less quantum ghost imaging: New two-photon experiments SO VACUUM LA English DT Article; Proceedings Paper CT 6th International Symposium on Applied Plasma Science CY SEP 24-28, 2007 CL Nikko, JAPAN DE Lens-less imaging; Quantum imaging; Two-photon; Ghost Imaging ID ENTANGLEMENT; INTERFERENCE; DIFFRACTION AB New types of lens-less two-photon ghost imaging experiments are described that can also be useful for 3D X-ray imaging. In these experimental setups, a CCD array is placed facing a chaotic light source and gated by a photon counting detector that simply counts all randomly reflected photons from an object. A "ghost" image of the object is then observed from the gated CCD. A ghost image of an object can even be observed when the photon path to the photon counting device is obscured. These interesting demonstrations are not only useful for practical applications, such as X-ray lens-less imaging, but are also important from a fundamental point of view. These demonstrations lead to insight regarding the nonclassical two-photon interference nature of thermal light ghost imaging. Published by Elsevier Ltd. C1 [Meyers, Ronald E.; Deacon, Keith S.] USA, Res Lab, Adelphi, MD 20783 USA. RP Meyers, RE (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM rmeyers@arl.army.mil NR 20 TC 1 Z9 1 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0042-207X J9 VACUUM JI Vacuum PD SEP 4 PY 2008 VL 83 IS 1 SI SI BP 244 EP 247 DI 10.1016/j.vacuum.2008.04.069 PG 4 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA 358SO UT WOS:000259938000052 ER PT J AU Chung, MK Hebling, CM Jorgenson, JW Severin, K Lee, SJ Gagne, MR AF Chung, Mee-Kyung Hebling, Christine M. Jorgenson, James W. Severin, Kay Lee, Stephen J. Gagne, Michel R. TI Deracemization of a dynamic combinatorial library induced by (-)-cytidine and (-)-2-thiocytidine SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID COLLISION-INDUCED DISSOCIATION; IONIZATION-MASS-SPECTROMETRY; HOST-GUEST BINDING; GAS-PHASE; NONCOVALENT COMPLEXES; MOLECULAR RECOGNITION; DIASTEREOSELECTIVE AMPLIFICATION; ASYMMETRIC-SYNTHESIS; ALPHA-METHYLALANINE; KINETIC RESOLUTION AB A dynamic combinatorial library composed of racemic hydrazone-based dipeptides becomes deracemized on binding to the chiral analytes (-)-cytidine and (-)-2-thiocytidine through the amplification of two receptors, (SS)-dimer and (RRRR)-tetramer. The deracemization phenomenon was investigated by laser polarimetry, mass-tagged pseudo-enantiomers in conjunction with electrospray ionization mass spectrometry, HPLC/UV-MS, UPLC/UV-MS, rapid-resolution LC-MS, collision-induced dissociation MS/MS, and numerical simulations. These data were consistent with a phenomenon where (SS)-dimer and (PPRR)-tetramer selectively bind the chiral analyte in preference to their enantiomeric counterparts, which ultimately causes them to be amplified and the library to become deracemized. C1 [Chung, Mee-Kyung; Hebling, Christine M.; Jorgenson, James W.; Gagne, Michel R.] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. [Severin, Kay] Ecole Polytech Fed Lausanne, Inst Sci & Ingenieries Chim, CH-1015 Lausanne, Switzerland. [Lee, Stephen J.] USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Gagne, MR (reprint author), Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. EM mgagne@unc.edu RI Hebling, Christine /H-3924-2012 FU Defense Threat Reduction Agency (DTRA) [W911NF06-1-0169]; Army Research Office [W911NF04D0004]; Swiss National Science Foundation; EPFL FX M.R.G. and J.W.J. thank the Defense Threat Reduction Agency (DTRA) for support (W911NF06-1-0169), S.T.L. thanks the Army Research Office (W911NF04D0004), and K.S. thanks the Swiss National Science Foundation and the EPFL for kind support. We also acknowledge helpful discussions with Prof. Marcey Waters (UNC Chapel Hill). NR 57 TC 32 Z9 32 U1 2 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD SEP 3 PY 2008 VL 130 IS 35 BP 11819 EP 11827 DI 10.1021/ja803658n PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA 342NY UT WOS:000258792000051 PM 18693687 ER PT J AU Rawson, ES Lieberman, HR Walsh, TM Zuber, SM Harhart, JM Matthews, TC AF Rawson, Eric S. Lieberman, Harris R. Walsh, Talia M. Zuber, Sylwia M. Harhart, Jaclyn M. Matthews, Tracy C. TI Creatine supplementation does not improve cognitive function in young adults SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE creatine monohydrate; phosphocreatine; ergogenic aid; brain; psychomotor; cognitive ID MAGNETIC-RESONANCE-SPECTROSCOPY; HUMAN SKELETAL-MUSCLE; ORAL SUPPLEMENTATION; HUMAN BRAIN; PERFORMANCE; HUMANS; VEGETARIANS; MONOHYDRATE; ACCUMULATION; ADAPTATIONS AB Creatine supplementation has been reported to improve certain aspects of cognitive and psychomotor function in older individuals and in young subjects following 24 and 36 h of sleep deprivation. However, the effects of creatine supplementation on cognitive processing and psychomotor performance in non-sleep deprived young adults have not been assessed with a comprehensive battery of neurocognitive tests. The primary objective of this study was to examine the effects of creatine supplementation on cognitive processing and psychomotor performance in young adults. Twenty-two subjects (21 +/- 2 yr) ingested creatine (0.03 g/kg/day) or placebo for 6 weeks in a double-blind placebo-controlled fashion. Subjects completed a battery of neurocognitive tests pre- and post-supplementation, including: simple reaction time (RT), code substitution (CS), code substitution delayed (CSD), logical reasoning symbolic (LRS), mathematical processing (MP), running memory (RM), and Sternberg memory recall (MR). There were no significant effects of group, no significant effects of time, and no significant group by time interactions for RT, CS, CSD, LRS, MO, RM, and MR (all p>0.05), indicating that there were no differences between creatine and placebo supplemented groups at any time. These results suggest that six weeks of creatine supplementation (0.03/g/kg/day) does not improve cognitive processing in non-sleep deprived young adults. Potentially, creatine supplementation only improves cognitive processing and psychomotor performance in individuals who have impaired cognitive processing abilities. (C) 2008 Elsevier Inc. All rights reserved. C1 [Rawson, Eric S.; Walsh, Talia M.; Zuber, Sylwia M.; Harhart, Jaclyn M.; Matthews, Tracy C.] Bloomsburg Univ Penn, Dept Exercise Sci & Athlet, Bloomsburg, PA 17815 USA. [Lieberman, Harris R.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. RP Rawson, ES (reprint author), Bloomsburg Univ Penn, Dept Exercise Sci & Athlet, 131 Centennial Hall, Bloomsburg, PA 17815 USA. EM erawson@bloomu.edu NR 30 TC 19 Z9 19 U1 0 U2 14 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD SEP 3 PY 2008 VL 95 IS 1-2 BP 130 EP 134 DI 10.1016/j.physbeh.2008.05.009 PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA 352ZO UT WOS:000259536100021 PM 18579168 ER PT J AU Lieberman, HR Caruso, CM Niro, PJ Adam, GE Kellogg, MD Nindl, BC Kramer, FM AF Lieberman, Harris R. Caruso, Christina M. Niro, Philip J. Adam, Gina E. Kellogg, Mark D. Nindl, Bradley C. Kramer, F. Matthew TI A double-blind, placebo-controlled test of 2 d of calorie deprivation: effects on cognition, activity, sleep, and interstitial glucose concentrations SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article ID MODERATE HYPOGLYCEMIA; BLOOD-GLUCOSE; ENVIRONMENTAL-STRESS; VISUAL VIGILANCE; LIQUID MEALS; PERFORMANCE; MOOD; DECREMENTS; CAFFEINE; TYROSINE AB Background: Anecdotal information and limited research suggest that short-term caloric deprivation adversely affects cognition. However, this issue has not been studied using double-blind, placebo-controlled procedures, because the formulation of a calorie-deficient feeding regimen identical to one with calories is impossible using ordinary foods. Therefore, test meals varying in caloric content, but indistinguishable in sensory characteristics, were formulated using hydrocolloid-based gels as the principal structural component. Objective: The purpose of this study was to examine the effects of 2 d of near-total caloric deprivation on cognitive function, satiety, activity, sleep, and glucose concentrations in a controlled environment. Design: A double-blind, placebo-controlled crossover study of caloric deprivation was conduced in a controlled environment for 48 h. Cognitive function in 27 healthy young subjects was assessed repeatedly with standardized tests of vigilance, reaction time, learning, memory, logical reasoning, mood, and satiety. Wrist-worn monitors were used to assess ambulatory vigilance, activity, and sleep. Interstitial glucose concentrations were assessed continuously with a minimally invasive monitor. Results: When the subjects received the near calorie-free diets, mean calorie consumption totaled 1311 kJ (313 kcal) over the testing period. During the fully fed treatment sessions, the subjects consumed a mean of 9612 kJ/d (2294 kcal/d), which matched their individual, daily energy requirements. Satiety and interstitial glucose concentrations were lower during the calorie-deprived diet (P < 0.001) than during the fully fed diet. There were no detectable effects of calorie deprivation on any aspect of cognitive performance, ambulatory vigilance, activity, or sleep. The mood states assessed, including fatigue, were not affected by calorie deprivation. Conclusions: Cognitive performance, activity, sleep, and mood are not adversely affected in healthy humans by 2 d of calorie-deprivation when the subjects and investigators are unaware of the calorie content of the treatments. C1 [Lieberman, Harris R.; Caruso, Christina M.; Niro, Philip J.; Kellogg, Mark D.] USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. [Adam, Gina E.; Nindl, Bradley C.] USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. [Kramer, F. Matthew] USA, Natick Soldier Res, Ctr Dev & Engn, Consumer Res Cognit Sci Team, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Bldg 42, Natick, MA 01760 USA. EM harris.lieberman@us.army.mil OI Kellogg, Mark/0000-0003-1868-2153 NR 56 TC 24 Z9 24 U1 1 U2 12 PU AMER SOC CLINICAL NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998 USA SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD SEP 1 PY 2008 VL 88 IS 3 BP 667 EP 676 PG 10 WC Nutrition & Dietetics SC Nutrition & Dietetics GA 346GV UT WOS:000259057700012 PM 18779282 ER PT J AU Stengel, JZ Jones, DP AF Stengel, Joel Z. Jones, David P. TI Single-Dose Lubiprostone Along With Split-Dose PEG Solution Without Dietary Restrictions for Bowel Cleansing Prior to Colonoscopy: A Randomized, Double-Blind, Placebo-Controlled Trial SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID CHLORIDE CHANNEL ACTIVATOR; LAVAGE SOLUTION; ELECTROLYTE SOLUTION; SODIUM-PHOSPHATE; EFFICACY; SAFETY; WHOLE AB OBJECTIVES: Proper colonic cleansing prior to colonoscopy is paramount to ensuring complete mucosal visualization and polyp identification. In a double-blind fashion, we compared single-dose lubiprostone (24 mu g) versus placebo pretreatment prior to a split-dose polyethylene glycol electrolyte (PEG-E) bowel preparation without dietary restriction to determine the efficacy, safety, and patient tolerability. METHODS: Two hundred patients referred for outpatient colorectal cancer screening were randomized to receive a single-dose of unlabeled lubiprostone (24 mu g) or placebo prior to a split-dose PEG-E bowel preparation without dietary restriction. The patients were surveyed prior to the colonoscopy on the tolerability of the bowel preparation, and any adverse events were recorded. The cleanliness of the colon was graded by the endoscopist during the procedure utilizing the Ottawa bowel preparation scale. RESULTS: One hundred ninety-one patients completed the study (95%). Split-dose PEG-E with lubiprostone pretreatment was found to be more effective at bowel cleansing in each segment of the colon when compared with split-dose PEG-E with placebo (P < 0.001). Patients enrolled in the lubiprostone treatment arm rated the overall experience as more tolerable (P 0.003) and complained of less abdominal bloating (P 0.049). No differences were observed between the groups for treatment-emergent side effects or adverse events (P > 0.05). CONCLUSIONS: Single-dose lubiprostone prior to split-dose PEG-E without dietary restriction significantly improves colonic mucosa visualization during colonoscopy and is well tolerated by patients. C1 [Stengel, Joel Z.; Jones, David P.] Brooke Army Med Ctr, Gastroenterol Serv, Ft Sam Houston, TX 78234 USA. RP Stengel, JZ (reprint author), Brooke Army Med Ctr, Gastroenterol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. FU Takeda Pharmaceuticals, Inc FX We thank Dr. Hays Arnold, Dr. John Godino, Dr. Stephen Harrison, and Dr. Michael Piesman for their assistance in performing the colonoscopies and evaluating the quality of the bowel preparation in this study. This study was funded by Takeda Pharmaceuticals, Inc. (protocol #07-023 L). It is registered with clinicaltrials.gov (ID NCT00611442). NR 16 TC 11 Z9 12 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 IS 9 BP 2224 EP 2230 DI 10.1111/j.1572-0241.2008.02053.x PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 362AG UT WOS:000260170000010 PM 18684185 ER PT J AU Acosta, R Riddle, M Veerappan, G May, E Cash, B AF Acosta, Ruben Riddle, Mark Veerappan, Ganesh May, Evan Cash, Brooks TI Miss rates of findings on colonoscopy after computed tomographic colonography (CTC): Correlation with polyp histology SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 Natl Naval Med Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USN, Med Res Ctr, Div Infect Dis, Silver Spring, MD USA. RI Riddle, Mark/A-8029-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 1384 BP S542 EP S543 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145201372 ER PT J AU Ally, M Veerappan, G Duncan, T Perry, J Maydonovitch, C Osgard, E Wong, R AF Ally, Mazer Veerappan, Ganesh Duncan, Timothy Perry, Joseph Maydonovitch, Corinne Osgard, Eric Wong, Roy TI Chronic Proton Pump Inhibitor therapy increases fundic gland polyps: How much is too much? SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Ally, Mazer; Veerappan, Ganesh; Duncan, Timothy; Perry, Joseph; Maydonovitch, Corinne; Osgard, Eric; Wong, Roy] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 138 BP S54 EP S54 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200139 ER PT J AU Bassett, J Arias, M Maydonovitch, C Sjogren, M AF Bassett, John Arias, Manuel Maydonovitch, Corinne Sjogren, Maria TI Depression and quality of life assessments in HCV genotype-1 patients treated with either consensus interferon (CIFN) and ribavirin (RBV) or pegylated interferon alfa-2b (PEG IFN) and ribavirin SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 Natl Naval Med Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 340 BP S131 EP S132 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200340 ER PT J AU Bassett, J Maydonovitch, C Lake, J AF Bassett, John Maydonovitch, Corinne Lake, Jason TI Tolerability of ambulatory esophageal pH monitoring using nasally placed pH catheter vs. BRAVO pH capsule SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 28 BP S12 EP S12 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200029 ER PT J AU Boger, J Gurevich-Uvena, J Frizzel, E Norris, W Maydonovitch, C Perry, J Laczek, J Wong, R AF Boger, John Gurevich-Uvena, Joyce Frizzel, Eric Norris, William Maydonovitch, Corinne Perry, Joseph Laczek, Jeffrey Wong, Roy TI The prevalence of gastroesophageal reflux in patients with paradoxical vocal fold motion SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Boger, John; Gurevich-Uvena, Joyce; Frizzel, Eric; Norris, William; Maydonovitch, Corinne; Perry, Joseph; Laczek, Jeffrey; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 64 BP S25 EP S26 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200065 ER PT J AU Cheatham, J Summers, T Patel, P Horwhat, JD AF Cheatham, Joseph Summers, Thomas Patel, Pranav Horwhat, John David TI Solitary duodenal polyp: a rare presentation of primary amyloidosis SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Cheatham, Joseph; Summers, Thomas; Patel, Pranav; Horwhat, John David] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 885 BP S346 EP S347 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200880 ER PT J AU Duncan, T Koff, J Moses, F AF Duncan, Timothy Koff, Jonathan Moses, Frank TI Chilaiditi syndrome & double balloon colonoscopy SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Duncan, Timothy; Koff, Jonathan; Moses, Frank] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 724 BP S284 EP S284 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200720 ER PT J AU Horwhat, JD Norris, W Young, P AF Horwhat, John David Norris, William Young, Patrick TI Feasibility of endoscopic intra-ductal balloon cryotherapy in the bile duct using a swine model SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Ctr, Dept Med, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 184 BP S71 EP S72 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200185 ER PT J AU Kwok, R Maydonovitch, C Wong, R AF Kwok, Ryan Maydonovitch, Corinne Wong, Roy TI Baclofen and hypnosis therapy in the treatment of rumination SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Kwok, Ryan; Maydonovitch, Corinne; Wong, Roy] Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 85 BP S35 EP S35 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200086 ER PT J AU Laczek, J Wong, R AF Laczek, Jeffrey Wong, Roy TI Gastroparesis following smallpox vaccination SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Laczek, Jeffrey; Wong, Roy] Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 723 BP S283 EP S284 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200719 ER PT J AU Laczek, J Duncan, M AF Laczek, Jeffrey Duncan, Marten TI Three cases of acute hepatitis in patients taking Hydroxycut (R) bodybuilding supplement SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 [Laczek, Jeffrey; Duncan, Marten] Walter Reed Army Med Ctr, Dept Gastroenterol, Washington, DC 20307 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 372 BP S143 EP S144 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200372 ER PT J AU Moawad, F LaRock, T Biondi, M Cash, B Kurland, J AF Moawad, Fouad LaRock, Todd Biondi, Michael Cash, Brooks Kurland, Jayde TI A case of obscure gastrointestinal bleeding secondary to a small bowel tumor detected by magnetic resonance enterography SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 586 BP S226 EP S227 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200582 ER PT J AU Moawad, F Goldkind, L AF Moawad, Fouad Goldkind, Lawrence TI An unusual case of drug induced colonic ischemia SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Meeting Abstract CT 73rd Annual Meeting of the American-College-of-Gastroenterology CY OCT 03-08, 2008 CL Orlando, FL SP Amer Coll Gastroenterol C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Naval Med Ctr, Bethesda, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 2008 VL 103 SU S MA 478 BP S184 EP S184 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 347MH UT WOS:000259145200474 ER PT J AU De Luigi, AJ Pasquina, P Dahl, E AF De Luigi, Arthur Jason Pasquina, Paul Dahl, Erik TI Rucksack-induced plexopathy mimicking a lateral antebrachial cutaneous neuropathy SO AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION LA English DT Article DE brachial plexopathy; neuropathy; rucksack; body armor ID MEDICAL ASPECTS; LOAD CARRIAGE; PARALYSIS; PALSY AB A 20-yr-old active duty soldier complained of right lateral forearm numbness that began shortly after carrying 100 lbs of equipment (20-lb load-bearing equipment, 20-lb individual body armor, and 60-lb rucksack) while deployed during Operation Iraqi Freedom. Physical examination revealed normal strength but decreased sensation over the right lateral forearm, thumb, and index finger. Imaging studies were normal. Electrodiagnostic studies revealed an absent right lateral antebrachial cutaneous nerve conduction study with abnormal electromyography findings in the right deltoid and biceps brachii. He was diagnosed with an upper trunk brachial plexopathy. The patient's symptoms gradually resolved with conservative treatment. Although rucksack palsies have been previously reported, this relatively rare cause of brachial plexus injury has been generally declining with the reengineering of more ergonomically favorable rucksacks. It is possible that the additional body armor may have contributed. C1 [De Luigi, Arthur Jason; Pasquina, Paul; Dahl, Erik] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP De Luigi, AJ (reprint author), Univ Utah, Univ Orthoped Ctr, 590 Wakara Way, Salt Lake City, UT 84105 USA. NR 13 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0894-9115 J9 AM J PHYS MED REHAB JI Am. J. Phys. Med. Rehabil. PD SEP PY 2008 VL 87 IS 9 BP 773 EP 775 DI 10.1097/PHM.0b013e3181837b83 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 341ZZ UT WOS:000258755700013 PM 18716490 ER PT J AU McGuire, JM Benton, BJ Burnett, DC Jakubowski, EM Thomson, SA AF McGuire, Jeffrey M. Benton, Bernard J. Burnett, David C. Jakubowski, Edward M., Jr. Thomson, Sandra A. TI Biomonitoring of Chemical Warfare Nerve Agents as a Dose Metric for Low-Level Exposures SO AMERICAN LABORATORY LA English DT Article ID SARIN C1 [McGuire, Jeffrey M.; Benton, Bernard J.; Burnett, David C.; Jakubowski, Edward M., Jr.; Thomson, Sandra A.] USA, Edgewood CB Ctr, Aberdeen Proving Ground, MD 21010 USA. RP McGuire, JM (reprint author), USA, Edgewood CB Ctr, 5183 Blackhawk Rd AMSRD ECB RT TN, Aberdeen Proving Ground, MD 21010 USA. EM Jeffrey.mcguire1@us.army.mil NR 9 TC 0 Z9 0 U1 1 U2 3 PU AMER LABORATORY-LABCOMPARE PI SHELTON PA 30 CONTROLS DRIVE, SHELTON, CT 06484 USA SN 0044-7749 J9 AM LAB JI Am. Lab. PD SEP PY 2008 VL 40 IS 17 SU S BP 6 EP + PG 2 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA 361GW UT WOS:000260116500002 ER PT J AU Laramee, JA Durst, HD Connell, TR Nilles, JM AF Laramee, James A. Durst, H. Dupont Connell, Theresa R. Nilles, J. Michael TI Detection of Chemical Warfare Agents on Surfaces Relevant to Homeland Security by Direct Analysis in Real-Time Spectrometry SO AMERICAN LABORATORY LA English DT Article ID MASS-SPECTROMETRY AB Direct Analysis in Real Time (DART (TM)) is an ion Source that provides near instantaneous mass spectrometric analysis of gases, liquids, and solids in open air under ambient conditions. The DART technique was used Successfully to detect chemical warfare agents on a variety of militarily relevant surfaces within 10 pg on glass. High-quality mass spectra were recorded with intensities of several hundred thousand ion counts and signal-to-noise ratios of 100,000:1. Exact mass measurement readily differentiates the analyte from chemical background interferences, thus reducing the likelihood of false positive test results. Time-consuming sample extractions, spraying solvents, or other sample manipulations are not needed. C1 [Laramee, James A.; Connell, Theresa R.; Nilles, J. Michael] Sci Applicat Int Corp, Aberdeen Proving Ground, MD 21010 USA. [Durst, H. Dupont] USA, Edgewood Chem Biol Ctr, Chem Methodol Team, Aberdeen Proving Ground, MD USA. RP Laramee, JA (reprint author), Sci Applicat Int Corp, Box 68, Aberdeen Proving Ground, MD 21010 USA. EM james.a.laramee@us.army.mil FU Research & Technology Directorate; Joint Science and Technology Office (JSTO); DoD Chemical and Biological Defense FX The authors gratefully acknowledge the facility support of the Research & Technology Directorate at the Edgewood Chemical Biological Center (ECBC), and fiscal support front the Agent Fate Program (DTO.42) by the Joint Science and Technology Office (JSTO) and the DoD Chemical and Biological Defense Program. They, are happy to have Theresa R. Connell as the newest member of the Edgewood DART Team. A long overdue thanks is owed to Dr. William R. Creasy (SAIC) who in 2002 kindly pointed out to the DART inventors the large cross section (100 angstrom) for the reaction of metastable helium with water. This document is unclassified and cleared for public release by ECBC. NR 7 TC 18 Z9 18 U1 0 U2 14 PU AMER LABORATORY-LABCOMPARE PI SHELTON PA 30 CONTROLS DRIVE, SHELTON, CT 06484 USA SN 0044-7749 J9 AM LAB JI Am. Lab. PD SEP PY 2008 VL 40 IS 16 BP 16 EP + PG 5 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA 358QJ UT WOS:000259932300004 ER PT J AU Hahn, CD Arciero, C Hwang, MO AF Hahn, Christina D. Arciero, Cletus Hwang, Moo O. TI Synchronous medullary and follicular carcinomas of the thyroid: A case report SO AMERICAN SURGEON LA English DT Letter C1 [Hahn, Christina D.; Arciero, Cletus; Hwang, Moo O.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. RP Hahn, CD (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD SEP PY 2008 VL 74 IS 9 BP 879 EP 881 PG 3 WC Surgery SC Surgery GA 344NC UT WOS:000258933400026 PM 18807685 ER PT J AU Rice, RD Reyes, AM Ltmdy, JB Seery, JM Johnson, EK Choi, YU AF Rice, Robert D. Reyes, Angel M. Ltmdy, Jonathan B. Seery, Jason M. Johnson, Eric K. Choi, Yong U. TI Preperitoneal Richter's hernia after laparoscopic gastric bypass: Management with a laparoscopic approach SO AMERICAN SURGEON LA English DT Letter C1 [Rice, Robert D.; Reyes, Angel M.; Ltmdy, Jonathan B.; Seery, Jason M.; Johnson, Eric K.; Choi, Yong U.] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA 30905 USA. RP Choi, YU (reprint author), Dwight D Eisenhower Army Med Ctr, Dept Surg, 300 Hosp Rd, Ft Gordon, GA 30905 USA. EM Yong.u.choi@us.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 141 WEST WIEUCA RD, STE B100, ATLANTA, GA 30342 USA SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD SEP PY 2008 VL 74 IS 9 BP 882 EP 883 PG 2 WC Surgery SC Surgery GA 344NC UT WOS:000258933400028 PM 18807687 ER PT J AU Holcomb, JB Wade, CE Michalek, JE Chisholm, GB Zarzabal, LA Schreiber, MA Gonzalez, EA Pomper, GJ Perkins, JG Spinella, PC Williams, KL Park, MS AF Holcomb, John B. Wade, Charles E. Michalek, Joel E. Chisholm, Gary B. Zarzabal, Lee Ann Schreiber, Martin A. Gonzalez, Ernest A. Pomper, Gregory. J. Perkins, Jeremy G. Spinella, Phillip C. Williams, Kari L. Park, Myung S. TI Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients SO ANNALS OF SURGERY LA English DT Review ID FRESH-FROZEN PLASMA; ABDOMINAL COMPARTMENT SYNDROME; DAMAGE CONTROL RESUSCITATION; ACUTE LUNG INJURY; FLUID RESUSCITATION; HEMORRHAGIC-SHOCK; WHOLE-BLOOD; DILUTIONAL COAGULOPATHY; COMBAT CASUALTIES; IMPROVED SURVIVAL AB Objective: To determine the effect of blood component ratios in massive transfusion (MT), we hypothesized that increased use of plasma and platelet to red blood cell (RBC) ratios Would result in decreased early hemorrhagic death and this benefit would be sustained over the ensuing hospitalization. Summary Background Data: Civilian guidelines for massive transfusion (MT >= 10 units of RBC in 24 hours) have typically recommend a 1:3 ratio of plasrna:RBC, whereas optimal platelet:RBC ratios are unknown. Conversely, military data shows that a plasma:RBC ratio approaching 1:1 improves long term outcomes in MT combat casualties. There is little consensus on optimal platelet transfusions in either civilian or military practice. At present, the optimal combinations of plasma, platelet, and RBCs for MT in civilian patients is unclear. Methods: Records of 467 MT trauma patients transported from the scene to 16 level 1 trauma centers between July 2005 and June 2006 were reviewed. One patient who died within 30 minutes of admission was excluded. Based on high and low plasma and platelet to RBC ratios, 4 groups were analyzed. Results: Among 466 MT patients, Survival varied by center from 41% to 74%. Mean injury severity score varied by center from 22 to 40; the average of the center means was 33. The plasma:RBC ratio ranged from 0 to 2.89 (mean +/- SD: 0.56 +/- 0.35) and the platelets: RBC ratio ranged from 0 to 2.5 (0.55 +/- 0.50). Plasma and platelet to RBC ratios and injury severity score were predictors of death at 6 hours, 24 hours, and 30 days in multivariate logistic models, Thirty-day survival was increased in patients with high plasma:RBC ratio (2:1:2) relative to those with low plasma:RBC ratio (< 1:2) (low: 40.4% vs. high: 59.6%, P < 0.01). Similarly, 30-day survival was increased in patients with high platelet:RBC ratio (>= 1:2) relative to those with low platelet:RBC ratio (< 1:2) (low: 40.1% vs. high: 59.9%, P < 0.01). The combination of high plasma and high platelet to RBC ratios were associated with decreased truncal hemorrhage, increased 6-hour, 24-hour, and 30-day survival, and increased intensive care unit, ventilator, and hospital-free days (P < 0.05), with no change in multiple organ failure deaths. Statistical modeling indicated that a clinical guideline with mean plasrna:RBC ratio equal to 1:1 would encompass 98% of patients within the optimal 1:2 ratio. Conclusions: Current transfusion practices and survival rates of MT patients vary widely among trauma centers. Conventional MT guidelines may underestimate the optimal plasma and platelet to RBC ratios. Survival in civilian MT patients is associated with increased plasma and platelet ratios. Massive transfusion practice guidelines should aim for a 1:1:1 ratio of plasma:platelets:RBCs. C1 [Holcomb, John B.; Wade, Charles E.; Williams, Kari L.; Park, Myung S.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. [Michalek, Joel E.; Chisholm, Gary B.; Zarzabal, Lee Ann] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA. [Schreiber, Martin A.] Oregon Hlth & Sci Univ, Dept Trauma Emergency & Gen Surg, Portland, OR 97201 USA. [Gonzalez, Ernest A.] Univ Texas Hlth Sci Ctr, Dept Surg, Houston, TX USA. [Pomper, Gregory. J.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Winston Salem, NC 27103 USA. [Perkins, Jeremy G.] Walter Reed Army Med Ctr, Bethesda, MD USA. [Spinella, Phillip C.] Connecticut Childrens Med Ctr, Hartford, CT USA. RP Holcomb, JB (reprint author), USA, Inst Surg Res, 3400 Rawley E,Chambers Ave, Ft Sam Houston, TX 78234 USA. EM John.holcomb@uth.tmc.edu NR 107 TC 520 Z9 545 U1 1 U2 16 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD SEP PY 2008 VL 248 IS 3 BP 447 EP 456 DI 10.1097/SLA.0b013e318185a9ad PG 10 WC Surgery SC Surgery GA 352DK UT WOS:000259475200020 PM 18791365 ER PT J AU Ellsworth, RE Vertrees, A Love, B Hooke, JA Ellsworth, DL Shriver, CD AF Ellsworth, Rachel E. Vertrees, Amy Love, Brad Hooke, Jeffrey A. Ellsworth, Darrell L. Shriver, Craig D. TI Chromosomal alterations associated with the transition from in situ to invasive breast cancer SO ANNALS OF SURGICAL ONCOLOGY LA English DT Article DE DCIS; invasive breast cancer; allelic imbalance ID COMPARATIVE GENOMIC HYBRIDIZATION; TUMOR-SUPPRESSOR GENES; TERM-FOLLOW-UP; DUCTAL CARCINOMA; MATRIX-METALLOPROTEINASES; HISTOLOGICAL GRADE; ALLELIC IMBALANCE; NUCLEAR GRADE; HETEROZYGOSITY; PATTERNS AB Background: Ductal carcinoma in situ (DCIS) is a preinvasive lesion of the breast with an inherent but nonobligatory tendency for progression to invasive breast cancer. Although the transition from in situ to invasive disease is critical to the development of breast cancer, molecular and biological changes responsible for this transition are not well characterized. Methods: Chromosomal alterations at 26 regions were assayed in 66 DCIS lesions and 111 invasive ductal carcinomas. Levels and patterns of allelic imbalance (AI) were compared between grade 1 DCIS and well-differentiated breast carcinomas, and between grade 3 DCIS and poorly differentiated invasive breast carcinomas, using Fisher's exact and Student's t-tests. Results: Levels of AI were significantly lower (P < 0.01) in grade 1 DCIS (11.9%) compared to well-differentiated carcinomas (19.2%), but were not significantly different between grade 3 DCIS and poorly differentiated tumors. No significant differences were detected at any of the 26 chromosomal regions between low-grade DCIS and invasive tumors; however, AI events at chromosomes 1p36, 11q23, and 16q11-q22 could discriminate high-grade in situ from invasive disease. Conclusion: Lower levels of AI in low-grade in situ compared with invasive disease may reflect the protracted time to progression associated with low-grade DCIS. Increased levels of AI at chromosomes 1p36 and 11q23 in poorly differentiated carcinomas may harbor genes associated with invasiveness, while loss of chromosome 16q11-q22 may prevent the transition from in situ to invasive disease. Further characterization of these changes may provide molecular assays to identify DCIS lesions with invasive potential as well as targets for molecular therapeutics. C1 [Ellsworth, Rachel E.] Henry M Jakcon Fdn Adv Mil Med, Clin Breast Care Project, Windber, PA 15963 USA. [Ellsworth, Rachel E.; Ellsworth, Darrell L.] Windber Res Inst, Clin Breast Care Project, Windber, PA 15963 USA. [Vertrees, Amy; Hooke, Jeffrey A.; Shriver, Craig D.] Walter Reed Army Med Ctr, Clin Breast Care Project, Washington, DC 20307 USA. [Love, Brad] Invitrogen, Carlsbad, CA 92008 USA. RP Ellsworth, RE (reprint author), Henry M Jakcon Fdn Adv Mil Med, Clin Breast Care Project, 620 7th St, Windber, PA 15963 USA. EM r.ellsworth@wriwindber.org FU United States Department of Defense [W81XWH05-2-0075]; [BCTR0600366] FX This research was supported by a grant from Susan G. Komen for the Cure (BCTR0600366) to R.E.E. and the United States Department of Defense (Military Molecular Medicine Initiative MDA W81XWH05-2-0075). The opinion and assertions contained herein are the private views of the authors and are not to be construed as official or as representing the views of the Department of the Army or the Department of Defense. NR 44 TC 13 Z9 13 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD SEP PY 2008 VL 15 IS 9 BP 2519 EP 2525 DI 10.1245/s10434-008-0051-7 PG 7 WC Oncology; Surgery SC Oncology; Surgery GA 339TM UT WOS:000258600200025 PM 18622645 ER PT J AU Holodniy, M Penzak, SR Straight, TM Davey, RT Lee, KK Goetz, MB Raisch, DW Cunningham, F Lin, ET Olivo, N Deyton, LR AF Holodniy, Mark Penzak, Scott R. Straight, Timothy M. Davey, Richard T. Lee, Kelvin K. Goetz, Matthew Bidwell Raisch, Dennis W. Cunningham, Francesca Lin, Emil T. Olivo, Noemi Deyton, Lawrence R. TI Pharmacokinetics and tolerability of oseltamivir combined with probenecid SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID INFLUENZA-A H5N1; NEURAMINIDASE; VIRUS; TRANSMISSION; INHIBITOR; ELIMINATION; VOLUNTEERS; PHOSPHATE; BINDING; H9N2 AB Oseltamivir is an inhibitor of influenza virus neuraminidase, which is approved for use for the treatment and prophylaxis of influenza A and B virus infections. In the event of an influenza pandemic, oseltamivir supplies may be limited; thus, alternative dosing strategies for oseltamivir prophylaxis should be explored. Healthy volunteers were randomized to a three-arm, open-label study and given 75 mg oral oseltamivir every 24 h (group 1), 75 mg oseltamivir every 48 h (q48h) combined with 500 mg probenecid four times a day (group 2), or 75 mg oseltamivir q48h combined with 500 mg probenecid twice a day (group 3) for 15 days. Pharmacokinetic data, obtained by noncompartmental methods, and safety data are reported. Forty-eight subjects completed the pharmacokinetic analysis. The study drugs were generally well tolerated, except for one case of reversible grade 4 thrombocytopenia in a subject in group 2. The calculated 90% confidence intervals (CIs) for the geometric mean ratios between groups 2 and 3 and group 1 were outside the bioequivalence criteria boundary (0.80 to 1.25) at 0.63 to 0.89 for group 2 versus group 1 and 0.57 to 0.90 for group 3 versus group 1. The steady-state apparent oral clearance of oseltamivir carboxylate was significantly less in groups 2 (7.4 liters/h; 90% CI, 6.08 to 8.71) and 3 (7.19 liters/h; 90% CI, 6.41 to 7.98) than in group 1 (9.75 liters/h; 90% CI, 6.91 to 12.60) (P < 0.05 for both comparisons by analysis of variance). The (arithmetic) mean concentration at 48 h for group 2 was not significantly different from the mean concentration at 24 h for group 1 (42 +/- 76 and 81 +/- 54 ng/ml, respectively; P = 0.194), but the mean concentration at 48 h for group 3 was significantly less than the mean concentration at 24 h for group 1 (23 +/- 26 and 81 +/- 54 ng/ml, respectively; P = 0.012). Alternate-day dosing of oseltamivir plus dosing with probenecid four times daily achieved trough oseltamivir carboxylate concentrations adequate for neuraminidase inhibition in vitro, and this combination should be studied further. C1 [Holodniy, Mark] VA Palo Alto Hlth Care Syst, Publ Hlth Res Ctr, Palo Alto, CA 94304 USA. [Holodniy, Mark; Deyton, Lawrence R.] US Dept Vet Affairs, Off Publ Hlth & Environm Hazards, Washington, DC USA. [Holodniy, Mark] Stanford Univ, Div Infect Dis & Geog Med, Stanford, CA 94305 USA. [Penzak, Scott R.] NIH, Clin Pharmacokinet Res Lab, Bethesda, MD 20892 USA. [Straight, Timothy M.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. [Davey, Richard T.] CRS LIR NIAID, NIH, Bethesda, MD USA. [Lee, Kelvin K.] VA Cooperat Studies Program, Palo Alto, CA USA. [Goetz, Matthew Bidwell] Greater Angeles Hlth Care Syst, Los Angeles, CA USA. [Goetz, Matthew Bidwell] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Infect Dis Sect, Los Angeles, CA 90095 USA. [Raisch, Dennis W.] Clin Res Pharm Coordinating Ctr, VA Cooperat Studies Program, Albuquerque, NM USA. [Cunningham, Francesca] US Dept Vet Affairs, Pharm Benefits Management Grp, Hines, IL USA. [Lin, Emil T.] UCSF, Dept Biopharmaceut Sci, San Francisco, CA USA. [Deyton, Lawrence R.] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20052 USA. RP Holodniy, M (reprint author), VA Palo Alto Hlth Care Syst, Publ Hlth Res Ctr, 3801 Miranda Ave 132, Palo Alto, CA 94304 USA. EM Holodniy@stanford.edu OI Goetz, Matthew/0000-0003-4542-992X FU U.S. Department of Veterans Affairs Merit; U.S. Departments of Defense; Health and Human Services FX This work was supported by a U.S. Department of Veterans Affairs Merit review grant to Mark Holodniy and additional financial support from the U.S. Departments of Defense (T. M. Straight) and Health and Human Services (R. T. Davey and S. R. Penzak).; None of the authors have any significant conflict of interest related to this study.; We thank the study participants, Cooperative Studies Program staff (Nigel Gladhart, Lauren Uyeda, Sachiko Kutsuna) for data management, and the data safety monitoring committee members (Thomas C. Merigan, Rex Jamison, and Larry Mole). NR 37 TC 33 Z9 35 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2008 VL 52 IS 9 BP 3013 EP 3021 DI 10.1128/AAC.00047-08 PG 9 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 340TG UT WOS:000258667300003 PM 18559644 ER PT J AU Heine, HS Bassett, J Miller, L Bassett, A Ivins, BE Lehoux, D Arhin, FF Parr, TR Moeck, G AF Heine, H. S. Bassett, J. Miller, L. Bassett, A. Ivins, B. E. Lehoux, D. Arhin, F. F. Parr, T. R., Jr. Moeck, G. TI Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID AEROSOL CHALLENGE MODEL; POSTEXPOSURE PROPHYLAXIS; STAPHYLOCOCCUS-AUREUS; PHARMACOKINETICS; SUSCEPTIBILITY; ANTIBIOTICS; MACROPHAGES; DOXYCYCLINE; INFECTIONS; MANAGEMENT AB The inhaled form of Bacillus anthracis infection may be fatal to humans. The current standard of care for inhalational anthrax postexposure prophylaxis is ciprofloxacin therapy twice daily for 60 days. The potent in vitro activity of oritavancin, a semisynthetic lipoglycopeptide, against B. anthracis (MIC against Ames strain, 0.015 mu g/ml) prompted us to test its efficacy in a mouse aerosol-anthrax model. In postexposure prophylaxis dose-ranging studies, a single intravenous (i.v.) dose of oritavancin of 5, 15, or 50 mg/kg 24 h after a challenge with 50 to 75 times the median lethal dose of Ames strain spores provided 40, 70, and 100% proportional survival, respectively, at 30 days postchallenge. Untreated animals died within 4 days of challenge, whereas 90% of control animals receiving ciprofloxacin at 30 mg/kg intraperitoneally twice daily for 14 days starting 24 h after challenge survived. Oritavancin demonstrated significant activity post symptom development; a single i.v. dose of 50 mg/kg administered 42 h after challenge provided 56% proportional survival at 30 days. In a preexposure prophylaxis study, a single i.v. oritavancin dose of 50 mg/kg administered 1, 7, 14, or 28 days before lethal challenge protected 90, 100, 100, and 20% of mice at 30 days; mice treated with ciprofloxacin 24 h or 24 and 12 h before challenge all died within 5 days. Efficacy in pre- and postexposure models of inhalation anthrax, together with a demonstrated low propensity to engender resistance, promotes further study of oritavancin pharmacokinetics and efficacy in nonhuman primate models. C1 [Heine, H. S.; Bassett, J.; Miller, L.; Bassett, A.; Ivins, B. E.] USA, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA. [Lehoux, D.; Arhin, F. F.; Parr, T. R., Jr.; Moeck, G.] Targanta Therapeut, St Laurent, PQ, Canada. RP Heine, HS (reprint author), USA, Med Res Inst Infect Dis, Div Bacteriol, 1425 Porter St, Ft Detrick, MD 21702 USA. EM henry.heine@amedd.army.mil FU Defense Threat Reduction Agency [02-4-2C-013] FX The research with B. anthracis described herein was sponsored by the Defense Threat Reduction Agency, project 02-4-2C-013 (H.S.H.). The opinions, interpretations, conclusions, and recommendations are ours and are not necessarily endorsed by the U. S. Army and the Department of Defense.; We thank Karine Laquerre, Valerie Ostiguy, Ibtihal Fadhil, Cordelia Cadieux, Odette Belanger, and Adel Rafai Far for characterizing oritavancin pharmacokinetics in mice. We acknowledge the support of Ingrid Sarmiento for assistance with stepwise selection experiments. NR 42 TC 17 Z9 18 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 2008 VL 52 IS 9 BP 3350 EP 3357 DI 10.1128/AAC.00360-08 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 340TG UT WOS:000258667300047 PM 18606841 ER PT J AU Pennington, G Kilpatrick, SJ Wickenden, AE AF Pennington, G. Kilpatrick, S. J. Wickenden, A. E. TI Hot optical phonon decay in carbon nanotubes SO APPLIED PHYSICS LETTERS LA English DT Article AB We simulate hot optical phonon decay in small diameter (< 0.7 nm) carbon nanotubes, solving the phonon Boltzmann transport equation using Monte Carlo methods incorporating the full phonon spectrum and phonon-phonon scattering. Results indicate decay times inversely proportional to the lattice temperature with negligible dependence on hot phonon polarization/wave vector or nanotube diameter and chirality. Nonequilibrium optical phonons with energies of similar to 0.2 eV decay by emitting two similar to 0.1 eV optical phonons, corresponding to out-of-plane polarization modes in graphitic materials. Modes polarized perpendicular to the nanotube axis may allow manipulation of hot phonon effects by the near environment of the nanotube. (C) 2008 American Institute of Physics. C1 [Pennington, G.; Kilpatrick, S. J.; Wickenden, A. E.] USA, Res Lab, Adelphi, MD 20783 USA. RP Pennington, G (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM gary.w.pennington@gmail.com FU Army Research Laboratory; Oakridge Associated Universities FX The first author thanks the Army Research Laboratory and Oakridge Associated Universities for support. NR 20 TC 10 Z9 10 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 1 PY 2008 VL 93 IS 9 AR 093110 DI 10.1063/1.2975376 PG 3 WC Physics, Applied SC Physics GA 345DH UT WOS:000258975800061 ER PT J AU Zheleva, T Derenge, M Ewing, D Shah, P Jones, K Lee, U Robins, L AF Zheleva, T. Derenge, M. Ewing, D. Shah, P. Jones, K. Lee, U. Robins, L. TI Improved performance of Schottky diodes on pendeoepitaxial gallium nitride SO APPLIED PHYSICS LETTERS LA English DT Article ID DISLOCATION DENSITY; PENDEO-EPITAXY; GAN; REDUCTION AB We designed experiments to investigate the role of dislocation density on the performance of Schottky diodes fabricated on a GaN material grown conventionally and by pendeo-epitaxy. Devices of varying geometries were fabricated on low defect density GaN regions grown selectively via pendeo-epitaxy. In addition, corresponding devices were fabricated on the conventional GaN material with a high density of dislocations. Schottky diodes fabricated on pendeo-material showed nearly two orders of magnitude lower leakage current and displayed improved ideality factor, while diodes built on a conventional material displayed nonideal characteristics. (c) 2008 American Institute of Physics. C1 [Zheleva, T.; Derenge, M.; Ewing, D.; Shah, P.; Jones, K.; Lee, U.] USA, Res Lab, AMSRD SE RL, SEDD, Adelphi, MD 20783 USA. [Robins, L.] NIST, Div Mat Reliabil, Boulder, CO 80305 USA. RP Zheleva, T (reprint author), USA, Res Lab, AMSRD SE RL, SEDD, Adelphi, MD 20783 USA. EM tzheleva@arl.army.mil NR 14 TC 4 Z9 4 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 1 PY 2008 VL 93 IS 9 AR 091909 DI 10.1063/1.2978404 PG 3 WC Physics, Applied SC Physics GA 345DH UT WOS:000258975800031 ER PT J AU Austad, GT Higgs, JB AF Austad, Gregory T. Higgs, Jay B. TI Occult knee effusions in the intensive care environment by ultrasound: A new third space? SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Rheumatology/43rd Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 24-29, 2008 CL San Francisco, CA SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 [Austad, Gregory T.; Higgs, Jay B.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2008 VL 58 IS 9 SU S BP S469 EP S470 PG 2 WC Rheumatology SC Rheumatology GA 348XU UT WOS:000259244201077 ER PT J AU Tofferi, JK Moratz, C Tsokos, GC AF Tofferi, Jeanne K. Moratz, Chantal Tsokos, George C. TI C3b independent Ischemia/reperfusion-induced intestinal injury in autoimmune prone (MRL/Ipr) mice SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract CT 72nd Annual Scientific Meeting of the American-College-of-Rheumatology/43rd Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals CY OCT 24-29, 2008 CL San Francisco, CA SP Amer Coll Rheumatol, Assoc Rheumatol Hlth Profess C1 [Tofferi, Jeanne K.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Moratz, Chantal] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Tsokos, George C.] Harvard Univ, Sch Med, Boston, MA USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 2008 VL 58 IS 9 SU S BP S322 EP S322 PG 1 WC Rheumatology SC Rheumatology GA 348XU UT WOS:000259244200439 ER PT J AU Killgore, WDS Grugle, NL Killgore, DB Leavitt, BP Watlington, GI McNair, S Balkin, TJ AF Killgore, William D. S. Grugle, Nancy L. Killgore, Desiree B. Leavitt, Brian P. Watlington, George I. McNair, Shanelle Balkin, Thomas J. TI Restoration of risk-propensity during sleep deprivation: Caffeine, dextroamphetamine, and modafinil SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE sleep deprivation; risk; stimulants; caffeine; dextroamphetamine; modafinil ID DECISION-MAKING; D-AMPHETAMINE; SENSATION-SEEKING; 24 H; RELIABILITY; PERFORMANCE; INHIBITION; OPERATIONS; ALERTNESS; VALIDITY AB Introduction: Sleep deprivation alters risk-related judgments, decision-making, and behavioral control. Stimulant medications are used to restore cognitive performance, but their effects on risk-taking and judgment in sleep-deprived subjects have not been explored. Methods: There were 54 healthy adults (29 men, 25 women; age range 18 to 36) who completed a test of cognitive ability and daily measures of risk-taking propensity, including the Brief Sensation Seeking Scale (BSSS), Evaluation of Risks (EVAR) scale, and the Balloon Analog Risk Task (BART). Following 44 h of continuous wakefulness, participants ingested caffeine 600 mg (N = 12), dextroamphetamine 20 mg (N = 16), modafinil 400 mg (N = 12), or a placebo (N = 14) in a double blind manner, and completed risk-taking measures 2 h later (i.e., 0535). Results: Relative to rested baseline, the placebo group showed a decline in risk-taking as measured by the BSSS (16% decline), EVAR Danger Seeking (32% decline) and Energy (22% decline), and BART (32% decline), consistent with previous reports of the effects of sleep deprivation. Comparisons among drug conditions showed that dextroamphetamine restored risk-taking propensity and risky behavior to baseline levels, an effect that was significantly greater than placebo or caffeine for several indices of risk-taking, but which did not differ from modafinil. Cognitive ability was significantly correlated with changes on some risk-taking indices following stimulant administration. Conclusions: Stimulant medications, particularly dextroamphetamine, sustained risk-related attitudes and behavior during continuous wakefulness. The extent to which stimulants restore other aspects of judgment during sleep loss remains to be determined. C1 [Killgore, William D. S.] Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, Belmont, MA 02478 USA. [Leavitt, Brian P.; Watlington, George I.; McNair, Shanelle; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. [Grugle, Nancy L.] Lockheed Martin, Bethesda, MD USA. RP Killgore, WDS (reprint author), Harvard Univ, Sch Med, McLean Hosp, Neuroimaging Ctr, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu OI Killgore, William/0000-0002-5328-0208 NR 33 TC 26 Z9 26 U1 2 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2008 VL 79 IS 9 BP 867 EP 874 DI 10.3357/ASEM.2259.2008 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 344UG UT WOS:000258952200005 PM 18785355 ER PT J AU DeGroot, DW Kenney, WL AF DeGroot, David W. Kenney, W. Larry TI Thermal response to running across the Sahara desert: Data for three men SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE telemetry pill; core temperature; thermoregulation; heat; metabolic rate ID ENERGY-EXPENDITURE; CORE TEMPERATURE; HEAT-EXCHANGE; EXERCISE; WALKING AB Background: There are limited data concerning the physiological responses to long-duration exercise collected under field conditions, and less data under harsh environmental conditions. This paper describes select environmental conditions and physiological responses of three runners attempting to run across the entire Sahara desert over a 111-d period. Methods: The runners started in Saint-Louis, Senegal, and we collected data on 2 d at the start of the expedition. Core temperature was measured via telemetry pill (T-pill), heart rate via Polar monitor, and metabolic rate (M) was estimated from two equations. The Pandolf equation uses movement speed and grade while Berglund's equation predicts M from heart rate and dry-bulb temperature. Data are presented as mean SD (range). Results: The runners intermittently ran 8.0 km . h(-1) over 6 h during Night (warm-humid) conditions and 6.9 km . h(-1) over 7 h 40 min during Day (hot-dry) desert conditions. Mean T-pill was similar for both days (37.8 +/- 10.34 vs. 37.82 +/- 0.50 degrees C) while range was greater during the day (Day: 36.69-38.91 vs. Night: 37.11-38.48 degrees C). Heart rate was 128 +/- 16 (72-156) and 119 +/- 17 (75-147) bpm for Night and Day, respectively. M-mean was 299 +/- 66 (65-418) W.m(-2) and 364 +/- 117 (58-542) W . m(-2) during Night and 239 +/- 60 (67-356) and 244 +/- 139 (54-464) W . m(-2) during Day, estimated by Berglund and Pandolf, respectively. Conclusions: During Day, the athletes ran slower than during Night, though T-pill was similar, indicative of the greater environmental strain. Mean predicted M was similar between equations, though maximum and minimal values were more extreme and rate-of-change dynamics faster according to Pandolf's equation. C1 [DeGroot, David W.] USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. [Kenney, W. Larry] Penn State Univ, Dept Kinesiol, University Pk, PA 16802 USA. [Kenney, W. Larry] Penn State Univ, Intercoll Grad Degree Program Physiol, University Pk, PA 16802 USA. RP DeGroot, DW (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. EM david.degroot@amedd.army.mil FU Gatorade Sports Science Institute FX The authors thank the runners for their exceptional efforts under harsh conditions and for providing us With the opportunity to study them during their expedition. Beth Stover Mooradian, M.S., and John Eric Smith, Ph.D., of the Gatorade Sports Science Institute assisted with data collection in Senegal and Mauritania and their contributions are appreciated. At the U.S. Army Research Institute of Environmental Medicine, William Santee, Ph.D., loaned us the weather monitoring equipment and Larry Berglund, Ph.D., assisted With the metabolic rate prediction equations. This project was funded by the Gatorade Sports Science Institute. NR 15 TC 0 Z9 1 U1 0 U2 39 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 2008 VL 79 IS 9 BP 909 EP 913 DI 10.3357/ASEM.2178.2008 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 344UG UT WOS:000258952200011 PM 18785361 ER PT J AU Gao, XG Ray, R Xiao, Y Ray, P AF Gao, Xiugong Ray, Radharaman Xiao, Yan Ray, Prabhati TI Suppression of inducible nitric oxide synthase expression and nitric oxide production by macrolide antibiotics in sulfur mustard-exposed airway epithelial cells SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY LA English DT Article ID NF-KAPPA-B; IN-VITRO; FLUORESCENT-PROBE; ROXITHROMYCIN; INFLAMMATION; LUNG; VIVO; MACROPHAGES; METABOLITES; MODULATION AB Sulfur mustard, a vesicant chemical warfare agent, causes airway injury due to massive release of destructive enzymes and mediators of inflammation. Nitric oxide plays an important yet controversial role in inflammation. An impressive number of reports suggest that excessive amount of nitric oxide may promote inflammation-induced cell injury and death. Overproduction of nitric oxide is catalysed by up-regulated expression of the inducible isoform of nitric oxide synthase (iNOS). In this study, we used quantum dot-mediated immunocytochemistry to analyse iNOS expression and flow cytometry to analyse the intracellular nitric oxide production in sulfur mustard-exposed normal human small airway epithelial cells and bronchial/tracheal epithelial cells and studied the effect of four US Food and Drug Administration-approved macrolide antibiotics, namely, azithromycin, clarithromycin, erythromycin and roxithromycin. Exposure to 100 mu M sulfur mustard significantly up-regulated iNOS expression and resulted in overproduction of nitric oxide in these cells. Addition of macrolide antibiotics to 100 mu M in the medium reduced both iNOS expression and nitric oxide production to near normal level. Thus, the current study provides in vitro evidence of the immunomodulatory effects of macrolide antibiotics in sulfur mustard-exposed airway epithelial cells. These results suggest that macrolide antibiotics may serve as potential vesicant respiratory therapeutics through mechanisms independent of their antibacterial activity. C1 [Ray, Prabhati] Walter Reed Army Inst Res, Div Expt Therapeut, Dept Biol, Mol Biol Sect, Silver Spring, MD 20910 USA. [Ray, Radharaman] USA, Med Res Inst Chem Def, Div Res, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD USA. [Xiao, Yan] Natl Inst Stand & Technol, Chem Sci & Technol Lab, DNA Measurements Grp, Gaithersburg, MD USA. RP Ray, P (reprint author), Walter Reed Army Inst Res, Div Expt Therapeut, Dept Biol, Mol Biol Sect, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM prabhati.ray@us.army.mil FU Defense Threat Reduction Agency [3.F0003_05_WR_C] FX This research was supported by the Defense Threat Reduction Agency Project No. 3.F0003_05_WR_C. NR 42 TC 17 Z9 19 U1 0 U2 4 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1742-7835 J9 BASIC CLIN PHARMACOL JI Basic Clin. Pharmacol. Toxicol. PD SEP PY 2008 VL 103 IS 3 BP 255 EP 261 DI 10.1111/j.1742-7843.2008.00255.x PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 337YV UT WOS:000258472300008 PM 18684233 ER PT J AU Little, SF Webster, WM Wilhelm, H Powell, B Enama, J Adamovicz, JJ AF Little, S. F. Webster, W. M. Wilhelm, H. Powell, B. Enama, J. Adamovicz, J. J. TI Evaluation of quantitative anti-F1 IgG and anti-V IgG ELISAs for use as an in vitro-based potency assay of plague vaccine in mice SO BIOLOGICALS LA English DT Article DE enzyme-linked immunosorbent assay; recombinant F1-V vaccine; plague; Yersinia pestis; potency assay ID SALMONICIDA SUBSP SALMONICIDA; YERSINIA-PESTIS; PNEUMONIC PLAGUE; ACTIVE IMMUNIZATION; PASTEURELLA-PESTIS; SUBUNIT VACCINE; FUSION PEPTIDE; GUINEA-PIGS; F1 CAPSULE; PROTEIN AB Quantitative anti-F1 and anti-V IgG enzyme-linked immunosorbent assays (ELISAs) were developed to measure the serological response of female Swiss Webster mice after vaccination with the recombinant fusion protein, rF1-V, which is being developed as a plague vaccine. Several fundamental parameters of the ELISA were evaluated: specificity, precision, accuracy, and stability. Experimental results suggested that a potency assay based upon the serological response of female Swiss Webster mice, as measured by quantitative anti-F1 IgG and anti-V IgG ELISAs, might be used to evaluate the rF1-V fusion protein vaccine. Published by Elsevier Ltd on behalf of The International Association for Biologicals. C1 [Little, S. F.; Webster, W. M.; Wilhelm, H.; Powell, B.; Enama, J.; Adamovicz, J. J.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Little, SF (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM stephen.little@amedd.army.mil FU U.S. Army Medical Research and Materiel Command [02-4-CC-009] FX The authors thank K. Kenyon for editorial assistance. The research described herein was sponsored by the U.S. Army Medical Research and Materiel Command, Project 02-4-CC-009. NR 37 TC 5 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 1045-1056 J9 BIOLOGICALS JI Biologicals PD SEP PY 2008 VL 36 IS 5 BP 287 EP 295 DI 10.1016/j.biologicals.2008.03.001 PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Pharmacology & Pharmacy GA 357ZP UT WOS:000259886200002 PM 18485733 ER PT J AU Kass, NE Otto, J O'Brien, D Minson, M AF Kass, Nancy E. Otto, Jean O'Brien, Daniel Minson, Matthew TI ETHICS AND SEVERE PANDEMIC INFLUENZA: MAINTAINING ESSENTIAL FUNCTIONS THROUGH A FAIR AND CONSIDERED RESPONSE SO BIOSECURITY AND BIOTERRORISM-BIODEFENSE STRATEGY PRACTICE AND SCIENCE LA English DT Article ID PUBLIC-HEALTH AB The response to severe pandemic influenza will be managed by experts in public health and infectious disease and by government officials to whom the public will turn for information and direction. Nonetheless, there remain important ethical considerations that can shape what goals are given priority, how scarce resources are distributed, how the public is included, and how we treat the most vulnerable in our response to a pandemic. This article assumes that the secondary consequences of severe pandemic influenza could be greater than deaths and illness from influenza itself. Response plans, then, must consider threats to societal as well as medical infrastructures. While some have suggested that scarce medical countermeasures be allocated primarily to first responders and then to the sickest, we suggest that an ethical public health response should set priorities based on essential functions. An ethical response also will engage the public, will coordinate interdependent sectors as a core preparedness priority, and will address how plans affect and can be understood by the least well off. C1 [Kass, Nancy E.] Johns Hopkins Univ, Dept Hlth Policy & Management, Bloomberg Sch Publ Hlth, Johns Hopkins Berman Inst Bioeth, Baltimore, MD 21218 USA. [O'Brien, Daniel] Dept Hlth & Mental Hyg, Off Maryland Attorney Gen, Baltimore, MD USA. [Otto, Jean] Walter Reed Army Inst Res, Armed Forces Hlth Surveillance Ctr, Global Emerging Infect Surveillance & Response Sy, Dept Defense, Silver Spring, MD USA. [Minson, Matthew] Dept Hlth & Human Serv, Washington, DC USA. RP Kass, NE (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Berman Bioeth Inst, 624 N Broadway,Hampton House 348, Baltimore, MD 21205 USA. EM nkass@jhsph.edu NR 40 TC 15 Z9 15 U1 1 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1538-7135 J9 BIOSECUR BIOTERROR JI Biosecur. Bioterror. PD SEP PY 2008 VL 6 IS 3 BP 227 EP 236 DI 10.1089/bsp.2008.0020 PG 10 WC Public, Environmental & Occupational Health; International Relations SC Public, Environmental & Occupational Health; International Relations GA 360JZ UT WOS:000260055100003 PM 18795832 ER PT J AU McGlasson, DL Romick, BG Rubal, BJ AF McGlasson, David L. Romick, Benjamin G. Rubal, Bernard J. TI Comparison of a chromogenic factor X assay with international normalized ratio for monitoring oral anticoagulation therapy SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE anticoagulation therapy; chromogenic factor X; international normalized ratio; warfarin therapy ID LUPUS ANTICOAGULANT; ANTIPHOSPHOLIPID SYNDROME; WARFARIN AB The purpose of the present study was to compare the international normalized ratio with a chromogenic factor X (CFX) assay for monitoring patients on oral anticoagulant therapy using the DiaPharma CFX method on a STA-R Evolution coagulation analyzer. International normalized ratio values were correlated with the CFX for determining normal, subtherapeutic, therapeutic and supratherapeutic ranges for these patients. Specimens were analyzed and grouped as normal or patients on oral anticoagulant therapy with international normalized ratios of less than 2.0, 2.0-3.0, and more than 3.0. Three hundred and nine randomly selected oral anticoagulant therapy patients were tested. The range of international normalized ratio and CFX in oral anticoagulant therapy patients was 0.92-12.76 and 9-132%, respectively. CFX was inversely related to international normalized ratio; R = 0.964 (P < 0.0001) (CFX = 13.2 + (5.3/international normalized ratio) + (81.3/ international normalized ratio(2)). Results by group were as follows: normal (n = 30), CFX range 72-131 %, mean CFX 96%; international normalized ratio less than 2.0 (n = 70), CFX range 32-132%, mean CFX 53%; international normalized ratio 2.0-3.0 (n = 135), CFX range 18-48%, mean CFX 28%; international normalized ratio more than 3.0 (n = 104), CFX range 9-46%, mean CFX 21 %. Sensitivity and specificity crossed at a CFX of 35.5%, which yielded a sensitivity of 91.7% and a specificity of 91.9% for discriminating international normalized ratio of at least 2.0. Area under the curve on receiver-operator curve using international normalized ratio was 0.984 (P < 0.001). In this randomly selected group of oral anticoagulant therapy patients and normal individuals at varying levels of anticoagulation, CFX correlated well with international normalized ratio as determined by R = 0.964. The data suggests that the CFX can be a useful tool for monitoring oral anticoagulation in patient populations in which confounders to international normalized ratio may be present. Further investigation with the use of CFX for monitoring is warranted in large patient populations on oral anticoagulant therapy, including follow-up for clinical outcomes. C1 [Rubal, Bernard J.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [McGlasson, David L.; Romick, Benjamin G.] Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. RP McGlasson, DL (reprint author), CLS INCA, 59MTG-SGRL,2200 Berquist Dr,Bldg 4430, Lackland AFB, TX 78236 USA. EM david.mcglasson@lackland.af.mil FU Surgeon General Office of the United States Air Force FX The authors of this manuscript would like to acknowledge George A. Fritsma, MS, MT (ASCP) proprietor of www.fritsmafactor.com.; There are no conflicts of interest by any of the authors that require disclosure.; The views expressed in this article are those of the authors and do not reflect the official policy of the Department of Defense or other Departments of the United States Government. This work was supported by the Surgeon General Office of the United States Air Force. NR 17 TC 9 Z9 9 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0957-5235 EI 1473-5733 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD SEP PY 2008 VL 19 IS 6 BP 513 EP 517 PG 5 WC Hematology SC Hematology GA 348KL UT WOS:000259209300007 PM 18685434 ER PT J AU Froehlich, KF Graham, MR Buchman, TG Girling, LG Scafetta, N West, BJ Walker, EKY McManus, BM Mutch, WAC AF Froehlich, Kevin F. Graham, M. Ruth Buchman, Timothy G. Girling, Linda G. Scafetta, Nicola West, Bruce J. Walker, Elizabeth K. -Y. McManus, Bruce M. Mutch, W. Alan C. TI Physiological noise versus white noise to drive a variable ventilator in a porcine model of lung injury SO CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE LA English DT Article ID HEART-RATE-VARIABILITY; LOW TIDAL VOLUMES; MECHANICAL VENTILATION; RECRUITMENT; OXYGENATION; DYNAMICS AB Purpose: Variable ventilation is superior to control mode ventilation in a number of circumstances. The nature of the breathing file used to deliver the variable rate and tidal volume has not been formally examined. Methods: We compared two different noise files in a randomized prospective trial of variable ventilation. Pigs were anesthetized, intubated, and mechanically ventilated. Oleic acid was infused to introduce lung injury. The animals were ventilated at a tidal volume of 7 mL.kg(-1), in variable mode, with either physiologically-derived noise (variability file - 1,587 breath intervals-obtained from a spontaneously breathing volunteer; n = 10) or a variability file of identical length derived from computer-generated white noise (n = 10). Results: The physiologically-derived noise had a power law alpha-exponent of -0.27 and a Holder exponent of -0.38, indicative of auto-correlated noise. The computer-gene rated noise had an alpha-exponent of -0.52 and a Holder exponent of -0.49, indicative of white noise. Both files showed multifractal characteristics. There were no differences between groups, at any time period, for PaO2, PaCO2 and static or dynamic respiratory system compliance. No differences were observed between groups for wet:dry lung weight ratios or for interleukin-8 in bronchoalveolar lavage fluid. Conclusion: This study demonstrates that the nature of the variability files, chosen to drive the variable ventilator, had no effect on indices of gas exchange or respiratory mechanics in this model. A considerable overlap of the multifractal files existed. The potential to drive a variable ventilator using algorithm-derived files with multifractal characteristics, thereby eliminating the requirement to use physiologically-derived signals, is discussed. C1 [Froehlich, Kevin F.; Graham, M. Ruth; Girling, Linda G.; Mutch, W. Alan C.] Univ Manitoba, Dept Anesthesia, Winnipeg, MB, Canada. [Buchman, Timothy G.] Washington Univ, Sch Med, St Louis, MO USA. [Scafetta, Nicola; West, Bruce J.] Duke Univ, Dept Phys, Durham, NC 27706 USA. [West, Bruce J.] USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. [Walker, Elizabeth K. -Y.; McManus, Bruce M.] Univ British Columbia, James Hogg iCapture Ctr, Vancouver, BC V5Z 1M9, Canada. RP Mutch, WAC (reprint author), Univ Manitoba, Dept Anesthesia, Winnipeg, MB, Canada. EM amutch@cc.umanitoba.ca OI Mutch, W. Alan/0000-0001-7174-7839; Buchman, Timothy/0000-0001-7350-5921; Scafetta, Nicola/0000-0003-0967-1911 FU Army Research Office [W911NF-06-1-0323] FX Nicola Scafetta thanks the Army Research Office for research support (grant W911NF-06-1-0323). NR 24 TC 6 Z9 6 U1 0 U2 1 PU CANADIAN ANESTHESIOLOGISTS SOC PI TORONTO PA 1 EGLINTON AVE EAST, SUITE 208, TORONTO, ONTARIO M4P 3A1, CANADA SN 0832-610X J9 CAN J ANAESTH JI Can. J. Anaesth.-J. Can. Anesth. PD SEP PY 2008 VL 55 IS 9 BP 577 EP 586 PG 10 WC Anesthesiology SC Anesthesiology GA 347JA UT WOS:000259135300003 PM 18840587 ER PT J AU Taktek, K Zinsser, N St-John, B AF Taktek, Khaled Zinsser, Nathaniel St-John, Bob TI Visual Versus Kinesthetic Mental Imagery: Efficacy for the Retention and Transfer of a Closed Motor Skill in Young Children SO CANADIAN JOURNAL OF EXPERIMENTAL PSYCHOLOGY-REVUE CANADIENNE DE PSYCHOLOGIE EXPERIMENTALE LA English DT Review DE mental imagery; kinesthetic imagery; visual imagery; motor performance; retention ID SPORTING PERFORMANCE; SEX-DIFFERENCES; SCHEMA THEORY; META-ANALYSIS; ACQUISITION; ABILITY; MOVEMENT; TASKS; INTERFERENCE; PERSPECTIVES AB The main purposes of this study were (a) to compare the effects of mental imagery combined with physical practise and specific physical practise on the retention and transfer of a closed motor skill in young children; (b) to determine the mental imagery (visual vs. kinesthetic), which is the most efficient for retention and transfer of a closed motor skill; and (c) to verify the relationship between movement image vividness and motor performance. As for the secondary purpose, it was to compare the effects of gender on motor learning. Participants (n = 96) were selected from 3 primary schools. These participants were divided into 6 groups and submitted to different experimental conditions. The experimental task required the participants to throw, with the nondominant hand (left hand), a ball toward a target composed of 3 concentric circles. The results demonstrated that performance obtained by the mental imagery (visual or kinesthetic) combined with physical practise group was, during the retention phase, equivalent to that produced by the specific physical practise group but significantly superior during the transfer of closed motor skill. These results showed the potential benefits of mental imagery as a retention strategy intended for motor skills and performance enhancement. Such results could be explained by the similarity of 3 principal functional evidences shared by mental and physical practise: behavioural, central, and peripheral (as suggested by Holmes & Collins, 2001). C1 [Taktek, Khaled] Laurentian Univ, Sch Educ, Sudbury, ON P3E 2C6, Canada. [Zinsser, Nathaniel] US Mil Acad, Performance Enhancement Program, West Point, NY USA. [St-John, Bob] Royal Mil Coll Canada, Dept Mil Psychol & Leadership, Kingston, ON, Canada. RP Taktek, K (reprint author), Laurentian Univ, Sch Educ, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada. EM ktaktek@laurentian.ca NR 116 TC 5 Z9 5 U1 4 U2 25 PU CANADIAN PSYCHOLOGICAL ASSOC PI OTTAWA PA 141 LAURIER AVE WEST, STE 702, OTTAWA, ONTARIO K1P 5J3, CANADA SN 1196-1961 J9 CAN J EXP PSYCHOL JI Can. J. Exp. Psychol.-Rev. Can. Psychol. Exp. PD SEP PY 2008 VL 62 IS 3 BP 174 EP 187 DI 10.1037/1196-1961.62.3.174 PG 14 WC Psychology, Experimental SC Psychology GA 531LI UT WOS:000272667200005 PM 18778146 ER PT J AU Mayes, DH Guerrero, ML AF Mayes, Danira H. Guerrero, Melanie L. TI A few good men - A marine with hemoptysis and diarrhea SO CHEST LA English DT Editorial Material ID IDIOPATHIC PULMONARY HEMOSIDEROSIS; CELIAC-DISEASE; CHILDREN C1 [Mayes, Danira H.; Guerrero, Melanie L.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Mayes, DH (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA. EM danira.mayes@amedd.army.mil NR 10 TC 9 Z9 10 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 EI 1931-3543 J9 CHEST JI Chest PD SEP PY 2008 VL 134 IS 3 BP 644 EP 647 DI 10.1378/chest.07-2834 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 349OP UT WOS:000259290500031 PM 18779201 ER PT J AU Balkin, TJ Rupp, T Picchioni, D Wesensten, NJ AF Balkin, Thomas J. Rupp, Tracy Picchioni, Dante Wesensten, Nancy J. TI Sleep loss and sleepiness - Current issues SO CHEST LA English DT Editorial Material DE cognitive performance; countermeasures; sleep deprivation; sleepiness ID PERFORMANCE DECREMENTS; INDIVIDUAL-DIFFERENCES; COGNITIVE FUNCTION; RECOVERY SLEEP; DOSE-RESPONSE; ONE NIGHT; DEPRIVATION; WAKEFULNESS; DURATION; MODAFINIL AB Awareness of the consequences of sleep loss and its implications for public health and safety is increasing. Sleep loss has been shown to generally, impair the entire spectrum of mental abilities, ranging from simple psychomotor performance to executive mental functions. Sleep loss may also impact metabolism in a manner that contributes to obesity and its attendant health consequences. Although objective measures of alertness and performance remain degraded, individuals subjectively habituate to chronic partial sleep loss (eg, sleep restriction), and recovery from this type of sleep loss is slow, factors that may help to explain the observation that many individuals, in the general population are chronically sleep restricted. Individual differences in habitual sleep duration appear to be a trait-like characteristic that is determined by several factors, including genetic polymorphisms. C1 [Balkin, Thomas J.; Rupp, Tracy; Picchioni, Dante; Wesensten, Nancy J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Balkin, TJ (reprint author), Walter Reed Army Inst Res, Dept Behav Biol, 503 Robert Grant Ave,Room 2A26, Silver Spring, MD 20910 USA. EM thomas.balkin@us.army.mil RI Rupp, Tracy/B-3605-2011 NR 56 TC 52 Z9 52 U1 2 U2 9 PU AMER COLL CHEST PHYSICIANS PI GLENVIEW PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA SN 0012-3692 J9 CHEST JI Chest PD SEP PY 2008 VL 134 IS 3 BP 653 EP 660 DI 10.1378/chest.08-1064 PG 8 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA 349OP UT WOS:000259290500033 PM 18779203 ER PT J AU Taylor, AJ Nissen, SE AF Taylor, Allen J. Nissen, Steven E. TI Preliminary Observations From Preliminary Trial Results Have We Finally Had Enough? SO CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES LA English DT Article C1 [Taylor, Allen J.] Walter Reed Army Med Ctr, Serv Cardiol, Washington, DC 20307 USA. [Nissen, Steven E.] Cleveland Clin, Dept Cardiovasc Med, Cleveland, OH 44106 USA. RP Taylor, AJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, 6900 Georgia Ave NW,Bldg 2,Room 4A34, Washington, DC 20307 USA. EM allen.taylor@amedd.army.mil FU Abbott Laboratories FX Dr Taylor receives research funding (without salary support) and speaker honoraria from Abbott Laboratories on the topic of HDL cholesterol and the use of niacin.; Dr Nissen reports that Cleveland Clinic Coordinating Center for Clinical Research has received research support to perform clinical trials from Pfizer, AstraZeneca, Novartis, Sankyo, Takeda, SanofiAventis, and Eli Lilly. Dr Nissen does not receive personal remuneration for conducting clinical trials. Dr Nissen consults for many pharmaceutical companies, but requires them to donate all honoraria or consulting fees directly to charity so that he receives neither income nor a tax deduction. NR 11 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1941-7705 EI 1941-7713 J9 CIRC-CARDIOVASC QUAL JI Circ.-Cardiovasc. Qual. Outcomes PD SEP PY 2008 VL 1 IS 1 BP 54 EP 57 DI 10.1161/CIRCOUTCOMES.108.811901 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA V11AK UT WOS:000207504300010 PM 20031788 ER PT J AU Parekh, D Miller, MA Borys, D Patel, PR Levsky, ME AF Parekh, Dina Miller, Michael A. Borys, Doug Patel, Paresh R. Levsky, Marc E. TI Transdermal patch medication delivery systems and pediatric poisonings, 2002-2006 SO CLINICAL PEDIATRICS LA English DT Article DE poisoning; pediatric; patch; transdermal ID INJURIES; RATES; AGE AB Transdermal drug delivery systems are an increasingly popular method of medication delivery containing large quantities of medication and presenting new opportunities for toxicity. To provide a description of exposures to transdermal medications in a pediatric population, we studied exposures in individuals less than 12 years of age. This is a retrospective database Study in which the Texas Poison Center Network database from 2002 to 2006 was reviewed. In all, 336 poison control center records of patch exposures over the 5-year period were identified. Of those, 110 cases involved children less than 12 years old. A majority of cases resulted in no significant clinical effects. One death resulted from opioid toxicity. Although a majority of patch exposures in children less than 12 years of age resulted in no significant clinical toxicity, practitioners and the public must be made aware of the available patch-based medications and their potential for toxicity in children. C1 [Miller, Michael A.] Tripler Army Med Ctr, Dept Emergency Med, Honolulu, HI 96859 USA. [Miller, Michael A.; Borys, Doug] Cent Texas Poison Control Ctr, Temple, TX USA. RP Miller, MA (reprint author), Tripler Army Med Ctr, Dept Emergency Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM michael.adam.miller@us.army.mil NR 19 TC 4 Z9 4 U1 0 U2 4 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD SEP PY 2008 VL 47 IS 7 BP 659 EP 663 DI 10.1177/0009922808315211 PG 5 WC Pediatrics SC Pediatrics GA 334XU UT WOS:000258255900004 PM 18497427 ER PT J AU Yeo, FE Yuan, CM Swanson, SJ Reinmuth, B Kiandoli, LC Kaplan, KJ Abbott, KC Reynolds, JC AF Yeo, Fred E. Yuan, Christina M. Swanson, Sydney J. Reinmuth, Bruce Kiandoli, Luana C. Kaplan, Keith J. Abbott, Kevin C. Reynolds, Joel C. TI The prevalence of BK polyomavirus infection in outpatient kidney transplant recipients followed in a single center SO CLINICAL TRANSPLANTATION LA English DT Article DE BK virus; decoy cells; infection kidney transplantation; screening; urinalysis ID RENAL-ALLOGRAFT RECIPIENTS; IMMUNOSUPPRESSIVE DRUGS; VIRUS NEPHROPATHY; URINE; PAPOVAVIRUS; MANAGEMENT; DISEASE; DNA AB Background: BK polyomavirus (BKV) infection has emerged as an important cause of renal allograft loss. There is no proven therapy, and much basic clinical information is still lacking. Methods: We serially enrolled 95 outpatient renal transplant recipients (43% of whom were African American) in a single center cross-sectional screening study to determine the prevalence of BKV infection by whole blood polymerase chain reaction, and the prevalence of decoy cells by urinalysis and cytology. We also investigated the demographic and clinical factors associated with BKV infection, and the performance of urinalysis for decoy cells as a screening test for BKV infection. Results: The point prevalence of active BKV viremia was 7.4%. When subjects without active viremia but with a history of viremia and/or nephropathy were included, the overall prevalence was 15.8%. Urinary decoy cells were common, present in 50% of subjects at study entry. Urinalysis for decoy cells as a screen for BKV viremia had a sensitivity of 86%, specificity of 52%, positive predictive value of 13% and negative predictive value of 98%. Conclusions: Decoy cells on urinalysis were the only factor independently associated with an increased risk of BKV infection on multivariate analysis. Although associated with BKV infection on univariate analysis, thymoglobulin, mycophenolate mofetil, and tacrolimus use were not independently associated with BKV infection on multivariate analysis, neither were history of acute rejection, gender, race, nor cause of end-stage renal disease. C1 [Yeo, Fred E.; Yuan, Christina M.; Kiandoli, Luana C.; Abbott, Kevin C.; Reynolds, Joel C.] Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. [Swanson, Sydney J.; Reinmuth, Bruce] Walter Reed Army Med Ctr, Renal Transplant Serv, Washington, DC 20307 USA. [Swanson, Sydney J.; Reinmuth, Bruce] Uniformed Serv Univ Hlth Sci, Washington, DC USA. [Kaplan, Keith J.] Walter Reed Army Med Ctr, Dept Pathol & Lab Serv, Washington, DC 20307 USA. RP Yuan, CM (reprint author), Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. EM christina.yuan@us.army.mil OI Abbott, Kevin/0000-0003-2111-7112 FU the WRAMC Department of Clinical Investigation [03-11006] FX We wish to acknowledge the Walter Reed Army Medical Center Department of Pathology and Area Laboratory Services Cytology Section, the clinical pathologists for their timely and careful evaluation of the urine cytology samples, and Ms. Linda Alexander for processing and submitting the samples for BKV Polymerase chain reaction determination. This study was funded by the WRAMC Department of Clinical Investigation under WU# 03-11006. NR 23 TC 14 Z9 17 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0902-0063 J9 CLIN TRANSPLANT JI Clin. Transplant. PD SEP-OCT PY 2008 VL 22 IS 5 BP 532 EP 541 DI 10.1111/j.1399-0012.2008.00817.x PG 10 WC Surgery; Transplantation SC Surgery; Transplantation GA 350GX UT WOS:000259341800002 PM 18651849 ER PT J AU Walvoord, AAG Redden, ER Elliott, LR Coovert, MD AF Walvoord, Ashley A. G. Redden, Elizabeth R. Elliott, Linda R. Coovert, Michael D. TI Empowering followers in virtual teams: Guiding principles from theory and practice SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE e-leadership; teams; computer-mediated communication ID E-LEADERSHIP; MEDIA USE; PERFORMANCE; ENVIRONMENTS; INTERFACES; KNOWLEDGE; OUTCOMES; SYSTEM; STYLE AB Effective leadership requires relationship skills such as - problem solving conflict management, motivation, communication, and listening [Yukl, G. A. (1998). Leadership in organizations. Upper Saddle River, NJ: Prentice Hall]. Arguably, nothing is more important to a leader than the skills involved in communicating one's intent to followers, for it is only through effectively transmitting intent that followers may understand and then execute the goals of the team and leader. The modern work-world is dominated by computer-mediated communication, and this communication is the bread and butter of virtual teams; however, simple transmission of information from point A to point B is not enough - the virtual environment presents significant challenges to effective communication. In this paper we review issues related to virtual teams and developments in multimodal displays that allow teams to communicate effectively via single or multiple modalities (e.g., visual, auditory, tactile). This discussion is grounded in guiding principles for design and use of information displays that were identified and culled based on multiple review criteria from an extensive review of the literature. We present an applied example of the utility of these guiding principles for multimodal display design, in the context of communicating a leader's presence to virtual followers via commander's intent. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Walvoord, Ashley A. G.; Coovert, Michael D.] Univ S Florida, Dept Psychol, Tampa, FL 33620 USA. [Redden, Elizabeth R.; Elliott, Linda R.] USA, Res Lab, ARL HRED SAIC, Ft Benning, GA 31905 USA. [Coovert, Michael D.] MDC & Associates Inc, Plant City, FL 33565 USA. RP Coovert, MD (reprint author), Univ S Florida, Dept Psychol, 4202 E Fowler Ave,PCD 4118G, Tampa, FL 33620 USA. EM coovert@luna.cas.usf.edu NR 75 TC 16 Z9 17 U1 2 U2 24 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD SEP PY 2008 VL 24 IS 5 BP 1884 EP 1906 DI 10.1016/j.chb.2008.02.006 PG 23 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 330XI UT WOS:000257975700009 ER PT J AU Orvis, KA Horn, DB Belanich, J AF Orvis, Karin A. Horn, Daniel B. Belanich, James TI The roles of task difficulty and prior videogame experience on performance and motivation in instructional videogames SO COMPUTERS IN HUMAN BEHAVIOR LA English DT Article DE challenge; instructional videogame; motivation; task difficulty; training performance; videogame experience ID SELF-EFFICACY; TRAINING EFFECTIVENESS; GOAL ORIENTATION; MENTAL EFFORT; COMPUTER; KNOWLEDGE; GAMES; SIMULATIONS; ENGAGEMENT; STRATEGIES AB Videogames are an increasingly popular instructional tool. This research investigated how various strategies for modifying task difficulty in instructional videogames impact learner performance and motivation. Further, the influence of prior videogame experience on these learning outcomes was examined, as well as the role prior experience played in determining the optimal approach for adjusting task difficulty. Participants completed a game-based training task under one of four task difficulty conditions: static, increasing, adaptive-low and adaptive-high. All participants completed an identical pre-training trial, 10 practice trials varying in difficulty level according to condition, and a final performance trial. Results demonstrate that learner performance and motivation significantly improved in all difficulty conditions. Further, prior videogame experience was found to significantly influence these learning outcomes and a three-way interaction was detected between performance, task difficulty condition, and experience. The results of this research provide information useful to instructional videogame developers and instructors utilizing videogames as instructional tools. Published by Elsevier Ltd. C1 [Orvis, Karin A.] Old Dominion Univ, Dept Psychol, Norfolk, VA 23529 USA. [Horn, Daniel B.; Belanich, James] USA, Res Inst Behav & Social Sci, Arlington, VA 22202 USA. RP Orvis, KA (reprint author), Old Dominion Univ, Dept Psychol, 250 Mills Godwin Bldg, Norfolk, VA 23529 USA. EM korvis@odu.edu RI Orvis, Karin/A-2523-2009 NR 64 TC 41 Z9 42 U1 1 U2 17 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0747-5632 EI 1873-7692 J9 COMPUT HUM BEHAV JI Comput. Hum. Behav. PD SEP PY 2008 VL 24 IS 5 BP 2415 EP 2433 DI 10.1016/j.chb.2008.02.016 PG 19 WC Psychology, Multidisciplinary; Psychology, Experimental SC Psychology GA 330XI UT WOS:000257975700041 ER PT J AU Parthasarathy, N DeShazer, D England, M Waag, DM AF Parthasarathy, Narayanan DeShazer, David England, Marilyn Waag, David M. TI Polysaccharide microarray technology for the detection of Burkholderia pseudomallei and Burkholderia mallei antibodies (vol 56, pg 329, 2006) SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Correction C1 [Parthasarathy, Narayanan; DeShazer, David; England, Marilyn; Waag, David M.] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Parthasarathy, N (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD SEP PY 2008 VL 62 IS 1 BP 117 EP 117 DI 10.1016/j.diagmicrobio.2006.11.016 PG 1 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA 345JZ UT WOS:000258994000022 ER PT J AU Mitchell, GW AF Mitchell, Glenn W. TI A Brief History of Triage SO DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS LA English DT Article C1 [Mitchell, Glenn W.] Sisters Mercy Hlth Syst, Clin Safety, Chesterfield, MO 63017 USA. [Mitchell, Glenn W.] USA, Med Corps, Washington, DC USA. RP Mitchell, GW (reprint author), Sisters Mercy Hlth Syst, Clin Safety, 13951 Meursault Lane, Chesterfield, MO 63017 USA. EM mitchellmd@aol.com NR 19 TC 5 Z9 6 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 1935-7893 J9 DISASTER MED PUBLIC JI Dis. Med. Public Health Prep. PD SEP PY 2008 VL 2 SU 1 BP S4 EP S7 DI 10.1097/DMP.0b013e3181844d43 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA V11GX UT WOS:000207521200002 PM 18769265 ER PT J AU Roksa, J Keith, B AF Roksa, Josipa Keith, Bruce TI Credits, time, and attainment: Articulation policies and success after transfer SO EDUCATIONAL EVALUATION AND POLICY ANALYSIS LA English DT Article DE articulation policy; community college; transfer ID COMMUNITY-COLLEGES; 4-YEAR COLLEGES; AGREEMENTS; 2-YEAR; NEED AB While state legislatures are increasingly enacting articulation policies, research to dale provides little evidence that these policies enhance students' likelihood. of transfer. Based on a careful historical review of state statutes, the authors propose that articulation policies do not improve transfer rates because that is not their intended purpose; the main goal of articulation policies is to prevent the loss of credits when students tran, fer within suite higher education systems. Subsequently, the authors use the National Education Longitudinal Study to evaluate articulation policies based oil all alternative set of outcomes: attainment of a bachelor's degree, time to degree, and credits required to complete a bachelors degree. They discuss the limitations of existing data and propose that future studies he designed to specifically evaluate the transfer or loss of credits applicable toward general education requirements. C1 [Roksa, Josipa] Univ Virginia, Charlottesville, VA 22904 USA. [Keith, Bruce] US Mil Acad, Off Dean, West Point, NY 10996 USA. RP Roksa, J (reprint author), Univ Virginia, POB 400766, Charlottesville, VA 22904 USA. EM jroksa@virginia.edu; bruce.keith@usma.edu NR 47 TC 16 Z9 16 U1 2 U2 13 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0162-3737 J9 EDUC EVAL POLICY AN JI Educ. Eval. Policy Anal. PD SEP PY 2008 VL 30 IS 3 BP 236 EP 254 DI 10.3102/0162373708321383 PG 19 WC Education & Educational Research SC Education & Educational Research GA 342TF UT WOS:000258805700002 ER PT J AU Su, D Santare, MH Gazonas, GA AF Su, Dan Santare, Michael H. Gazonas, George A. TI An effective medium model for elastic waves in microcrack damaged media SO ENGINEERING FRACTURE MECHANICS LA English DT Article DE waves; anisotropic damage; numerical experiment; effective moduli; microcracks ID ANISOTROPIC EFFECTIVE MODULI; NUMERICAL-SIMULATION; BOUNDARY-ELEMENT; CRACKED BODIES; SOLIDS; ROCKS; PROPAGATION; INCLUSIONS; SCATTERING; MECHANICS AB Direct numerical simulations of waves traveling through microcrack-damaged media are conducted and the results are compared to effective medium calculations to determine the applicability of the latter for studying wave propagation. Both tensile and compressive waves and various angular distributions of randomly-located cracks are considered. The relationships between the input wavelength and the output wave speed and output signal strength are studied. The numerical simulations show that the wave speed is nearly constant when 1/ka > 60 for tensile waves and 1/ka > 10 for compressive waves, where k is the wave number and a is the average half-crack length. The direct simulations also show that when the input wavelength is much longer than the crack length, 1/ka > 60, the wave can pass through the damaged medium relatively unattenuated. On the other hand, when the input wavelength is shorter than a "cut off " wave length, the output wave magnitude decreases linearly with the input wavelength. The effective medium wave speed and magnitude calculations are not dependent on the input wavelength and therefore the results correspond well with the numerical simulations for large 1/ka. This suggests a minimum wavelength for which the homogenized methods can be used for studying these problems. (c) 2008 Elsevier Ltd. All rights reserved. C1 [Su, Dan; Santare, Michael H.] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. [Su, Dan; Santare, Michael H.] Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. [Gazonas, George A.] USA Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Santare, MH (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM santare@me.udel.edu RI Santare, Michael/B-1725-2008; OI Gazonas, George/0000-0002-2715-016X NR 34 TC 3 Z9 3 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-7944 J9 ENG FRACT MECH JI Eng. Fract. Mech. PD SEP PY 2008 VL 75 IS 14 BP 4104 EP 4116 DI 10.1016/j.engfracmech.2008.04.003 PG 13 WC Mechanics SC Mechanics GA 322BN UT WOS:000257350300006 ER PT J AU Kennedy, AJ Hull, MS Steevens, JA Dontsova, KM Chappell, MA Gunter, JC Weiss, CA AF Kennedy, Alan J. Hull, Matthew S. Steevens, Jeffery A. Dontsova, Katerina M. Chappell, Mark A. Gunter, Jonas C. Weiss, Charles A., Jr. TI Factors influencing the partitioning and toxicity of nanotubes in the aquatic environment SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE nanotube; toxicity; fate; sediment; surface chemistry ID WALLED CARBON NANOTUBES; FULLERENES; C-60; SOLUBILIZATION; NANOPARTICLES; FLUORESCENCE; AGGREGATION; SONICATION; WATER AB Carbon nanotubes (NTs) may be among the most useful engineered nanomaterials for structural applications but could be difficult to study in ecotoxicological evaluations using existing tools relative to nanomaterials with a lower aspect ratio. Whereas the hydrophobicity and van der Waals interactions of NTs may suggest aggregation and sedimentation in aquatic systems, consideration regarding how engineered surface modifications influence their environmental fate and toxicology is needed. Surface modifications (e.g., functional groups and coatings) are intended to create conditions to make NTs dispersible in aqueous suspension, as required for some applications. In the present study, column stability and settling experiments indicated that raw, multiwalled NTs (MWNTs) settled more rapidly than carbon black and activated carbon particles, suggesting sediment as the ultimate repository. The presence of functional groups, however, slowed the settling of MWNTs (increasing order of stability: hydroxyl > carboxyl > raw), especially in combination with natural organic matter (NOM). Stabilized MWNTs in high concentrations of NOM provided relevance for water transport and toxicity studies. Aqueous exposures to raw MWNTs decreased Ceriodaphnia dubia viability, but such effects were not observed during exposure to functionalized MWNTs (> 80 mg/L). Sediment exposures of the amphipods Leptocheirus plumulosus and Hyalella azteca to different sizes of sediment-borne carbon particles at high concentration indicated mortality increased as particle size decreased, although raw MWNTs induced lower mortality (median lethal concentration [LC50], 50 to > 264 g/kg) than carbon black (LC50, 18 - 40 g/kg) and activated carbon (LC50, 12 - 29 g/kg). Our findings stress that it may be inappropriate to classify all NTs into one category in terms of their environmental regulation. C1 [Kennedy, Alan J.; Steevens, Jeffery A.; Dontsova, Katerina M.; Chappell, Mark A.] USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. [Weiss, Charles A., Jr.] USA, Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA. [Hull, Matthew S.] Virginia Polytech Inst & State Univ, Dept Civil & Environm Engn, Blacksburg, VA 24061 USA. [Gunter, Jonas C.] Luna Innovat, Blacksburg, VA 24060 USA. RP Kennedy, AJ (reprint author), USA, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. EM alan.j.kennedy@usace.army.mil RI Hull, Matt/F-4942-2012 NR 39 TC 106 Z9 107 U1 6 U2 70 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD SEP PY 2008 VL 27 IS 9 BP 1932 EP 1941 DI 10.1897/07-624.1 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 335WT UT WOS:000258325000013 PM 19086318 ER PT J AU Yokota, M Bathalon, GP Berglund, LG AF Yokota, Miyo Bathalon, Gaston P. Berglund, Larry G. TI Assessment of male anthropometric trends and the effects on simulated heat stress responses SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article; Proceedings Paper CT 2nd International Conference on Environmental Ergonomics CY 2007 CL Piran, SLOVENIA SP Ergon Soc DE anthropometry; thermal regulatory model; heat stress; core temperature; heart rate ID PHYSICAL-FITNESS; BODY DIMENSIONS; SECULAR TRENDS; US ARMY; WOMEN; MEN AB Assessing temporal changes in anthropometrics and body composition of US Army soldiers is important because these changes may affect fitness, performance, and safety. This study investigated differences in body dimensions (height, weight, percent body fat (%BF)) of US Army male soldiers by comparing 2004 and 1988 databases. Anthropometric somatotypes were identified and physiological responses of the different somatotypes to simulated heat stress (35 degrees C/50%rh, similar to 550 W work rate, carrying 12 kg load including battle dress uniform and body armor, rest for 30 min and walk for 70 min) using a thermal regulatory model were evaluated. A significant increase in body weight (2.4 kg) was observed between the 2004 and 1988 data (P < 0.05, after Bonferroni correction). However, changes in height and circumference measurements for %BF were insignificant, with the magnitude of the changes not exceeding inter-observer errors. Multivariate analyses demonstrated that anthropometric distributions did not differ between the two databases and identified five primary somatotypes: "tall-fat", "tall-lean", "average", "short-lean", and "short-fat." Within each database, anthropometric values differed among the somatotypes. However, simulated physiological responses to heat stress in each somatotype were similar in the 2004 and 1988 populations. In conclusion, an increase in body weight was the primary change observed in this sample of US Army male soldiers. Temporal changes in somatotypes of soldiers over a 16-year period had minimal impact on simulated physiological response to heat stress using a thermal regulatory model. C1 [Yokota, Miyo; Berglund, Larry G.] USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. [Bathalon, Gaston P.] USA, Environm Med Res Inst, Off Commander, Natick, MA 01760 USA. RP Yokota, M (reprint author), USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM Miyo.Yokota@us.army.mil NR 26 TC 9 Z9 9 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD SEP PY 2008 VL 104 IS 2 BP 297 EP 302 DI 10.1007/s00421-007-0656-8 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 339WZ UT WOS:000258609300021 PM 18196265 ER PT J AU Hadid, A Evans, RK Yanovich, R Luria, O Moran, DS AF Hadid, Amir Evans, Rachel K. Yanovich, Ran Luria, Orit Moran, Daniel S. TI Motivation, cohesion, satisfaction, and their relation to stress fracture among female military recruits SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article; Proceedings Paper CT 2nd International Conference on Environmental Ergonomics CY 2007 CL Piran, SLOVENIA SP Ergon Soc DE gender; military training; overuse injuries; female soldiers; personality traits ID CORONARY-PRONE BEHAVIOR; A BEHAVIOR; RUNNING INJURIES; ARMY TRAINEES; WOMEN; EXERCISE; ANXIETY; PATTERN; GENDER; TIBIA AB The purpose of this study was to compare ratings of motivation, satisfaction, self-efficacy, and cohesion between male and female soldiers undergoing basic training (BT) in a gender-integrated unit and to study whether the ratings differ in a subgroup of women who suffered stress fractures (SF) during the course of training. Data were collected from 3 different companies of an integrated combat unit using questionnaires that were completed by 41 male and 160 female soldiers (age 18.5 +/- 0.4 years) at 3 phases during their BT (0, 2, and 4 months). In these questionnaires, the subjects were asked to evaluate their motivation, cohesion, satisfaction and self-efficacy. The presence or absence of bone overuse injuries was assessed by magnetic resonance imaging (MRI) or bone scintigraphy (BS). In addition to comparing parameters between females and males, female soldiers who sustained SF during BT (n = 18) were analyzed as a separate sub-group (FSF). In general, females in a gender-integrated combat unit were more motivated and satisfied with their service than their male counterparts. Overall, the stress fractures were associated with lower ratings of motivation, self-efficacy, and satisfaction expressed by the FSF sub-group. C1 [Hadid, Amir] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. Tel Aviv Univ, Sackler Fac Med, IL-52621 Tel Hashomer, Israel. [Evans, Rachel K.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Luria, Orit] IAF, Tel Hashomer, Israel. RP Hadid, A (reprint author), Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel. EM amir.hadid@sheba.health.gov.il NR 26 TC 2 Z9 2 U1 1 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD SEP PY 2008 VL 104 IS 2 BP 329 EP 335 DI 10.1007/s00421-008-0717-7 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 339WZ UT WOS:000258609300025 PM 18415119 ER PT J AU Santangelo, JR Glisson, RR Garras, DN Easley, ME AF Santangelo, James R. Glisson, Richard R. Garras, David N. Easley, Mark E. TI Tibiotalocalcaneal arthrodesis: A biomechanical comparision of multiplanar external fixation with intramedullary fixation SO FOOT & ANKLE INTERNATIONAL LA English DT Article ID ANKLE ARTHRODESIS; SCREW FIXATION; NAIL; STABILITY; DEFORMITY; FUSION AB Methods of achieving tibiotalocalcaneal arthrodesis include intramedullary nailing, crossed lag screws, blade plates, and external fixation. While reports in the orthopaedic literature have compared the biomechanical properties of some of these fixation techniques, to our knowledge none has evaluated multiplanar external fixation. The purpose of this study was to compare the biomechanical properties of intramedullary nail fixation and external ring fixation for fibiotalocalcaneal arthrodesis. Materials and Methods: Tibiotalocalcaneal arthrodesis was performed on ten matched pairs of fresh-frozen human cadaveric legs. A ring fixator stabilized the arthrodesis in one leg from each pair and a 10 mm x 150 mm nail inserted retrograde across the subtalar and ankle joint stabilized the arthrodesis in the contralateral leg. The bending stiffness of the resulting constructs was quantified in plantarflexion, dorsiflexion, inversion, and eversion, and torsional stiffness was measured in internal and external rotation. Results: No difference in bending stiffness between the two constructs was identifiable in any of the four bending directions (p > 0.05). Torsional stiffness was approximately two-fold greater in both internal and external rotation in specimens with the ring fixator arthrodesis than in those with the intramedullary nail (p = 0.002). Conclusion: The ring fixator provides a stiffer construct than a 10 mm x 150 mm intramedullary nail in torsion, but no difference in bending stiffness was demonstrable. Both techniques can provide satisfactory fixation; however, the ring fixator may better minimize rotational joint motion. Clinical Relevance: This study provides a basis for selecting an arthrodesis method that offers optimized fixation. C1 [Santangelo, James R.] Womack Army Med Ctr, Dept Orthopaed Surg, Ft Bragg, NC 28310 USA. RP Santangelo, JR (reprint author), Womack Army Med Ctr, Dept Orthopaed Surg, Ft Bragg, NC 28310 USA. EM james.santangelo@us.army.mil NR 17 TC 15 Z9 17 U1 0 U2 1 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD SEP PY 2008 VL 29 IS 9 BP 936 EP 941 DI 10.3113/FAI.2008.0936 PG 6 WC Orthopedics SC Orthopedics GA 343XR UT WOS:000258890100015 PM 18778675 ER PT J AU Moawad, FJ Vetrappan, GR Wong, RKH AF Moawad, Fouad J. Vetrappan, Ganesh R. Wong, Roy K. H. TI Small bowel is the primary source of obscure gastrointestinal bleeding SO GASTROENTEROLOGY LA English DT Letter C1 [Moawad, Fouad J.; Vetrappan, Ganesh R.; Wong, Roy K. H.] Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. RP Moawad, FJ (reprint author), Walter Reed Army Med Ctr, Gastroenterol Serv, Washington, DC 20307 USA. NR 3 TC 7 Z9 12 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD SEP PY 2008 VL 135 IS 3 BP 1016 EP 1016 DI 10.1053/j.gastro.2008.05.083 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 346WC UT WOS:000259099300041 PM 18694750 ER PT J AU Gore, KL Engel, CC Freed, MC Liu, X Armstrong, DW AF Gore, Kristie L. Engel, Charles C. Freed, Michael C. Liu, Xian Armstrong, David W., III TI Test of a single-item posttraumatic stress disorder screener in a military primary care setting SO GENERAL HOSPITAL PSYCHIATRY LA English DT Article DE PTSD; screening; primary care ID MENTAL-HEALTH PROBLEMS; NATIONAL COMORBIDITY SURVEY; ADMINISTERED PTSD SCALE; PSYCHOMETRIC PROPERTIES; LIKELIHOOD RATIOS; VETERANS; IRAQ; AFGHANISTAN; PREVALENCE; CHECKLIST AB Background: Posttraumatic stress disorder (PTSD) is prevalent in primary care, frequently goes undetected and can be highly debilitating when untreated. Objective: We assessed the operating characteristics of a single-item PTSD screener (SIPS) for primary care and compared it to a commonly used four-item primary care PTSD screener (PC-PTSD). The SIPS asks: "Were you recently bothered by a past experience that caused you to believe you would be injured or killed... not bothered, bothered a little, or bothered a lot?" Methods: A total of 3234 patients from three Washington, DC, area military primary care clinics completed the SIPS. Independent, blinded assessments using a structured diagnostic PTSD interview were completed in 213 of these patients. Results: The SIPS yielded a reasonable range of likelihood ratios, suggesting capacity to discriminate between low- and high-probability PTSD patients. However, the SIPS sensitivity was only 76% for those reporting "bothered a little" and the four-item PC-PTSD yielded significantly better test characteristics on Receiver-Operator Curve analysis. Conclusion: A single, user-friendly primary care PTSD screening question with three response options, white sensible and worth further investigation, failed to offer sound test characteristics for PTSD screening. Ways of improving SIPS performance are discussed. (C) 2008 Elsevier Inc. All rights reserved. C1 [Gore, Kristie L.; Engel, Charles C.; Freed, Michael C.; Liu, Xian; Armstrong, David W., III] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. [Gore, Kristie L.; Engel, Charles C.; Freed, Michael C.; Liu, Xian; Armstrong, David W., III] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Gore, KL (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. EM kristie.gore@amedd.army.mil NR 41 TC 21 Z9 21 U1 4 U2 7 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0163-8343 J9 GEN HOSP PSYCHIAT JI Gen. Hosp. Psych. PD SEP-OCT PY 2008 VL 30 IS 5 BP 391 EP 397 DI 10.1016/j.genhosppsych.2008.05.002 PG 7 WC Psychiatry SC Psychiatry GA 352QY UT WOS:000259513700001 PM 18774421 ER PT J AU Ortiz, M Kaessmann, H Zhang, K Bashirova, A Carrington, M Quintana-Murci, L Telenti, A AF Ortiz, M. Kaessmann, H. Zhang, K. Bashirova, A. Carrington, M. Quintana-Murci, L. Telenti, A. TI The evolutionary history of the CD209 (DC-SIGN) family in humans and non-human primates SO GENES AND IMMUNITY LA English DT Article DE C-type lectins; HIV; Ebola; mycobacteria; innate immunity; DC-SIGN ID AMINO-ACID SITES; POSITIVE SELECTION; TYPE-1 INFECTION; INNATE-IMMUNITY; POLYMORPHISMS; RECEPTORS; DOMAIN; SUSCEPTIBILITY; TRIM5-ALPHA; LIKELIHOOD AB The CD209 gene family that encodes C-type lectins in primates includes CD209 (DC-SIGN), CD209L (L-SIGN) and CD209L2. Understanding the evolution of these genes can help understand the duplication events generating this family, the process leading to the repeated neck region and identify protein domains under selective pressure. We compiled sequences from 14 primates representing 40 million years of evolution and from three non-primate mammal species. Phylogenetic analyses used Bayesian inference, and nucleotide substitutional patterns were assessed by codon-based maximum likelihood. Analyses suggest that CD209 genes emerged from a first duplication event in the common ancestor of anthropoids, yielding CD209L2 and an ancestral CD209 gene, which, in turn, duplicated in the common Old World primate ancestor, giving rise to CD209L and CD209. K(A)/K(S) values averaged over the entire tree were 0.43 (CD209), 0.52 (CD209L) and 0.35 (CD209L2), consistent with overall signatures of purifying selection. We also assessed the Toll-like receptor (TLR) gene family, which shares with CD209 genes a common profile of evolutionary constraint. The general feature of purifying selection of CD209 genes, despite an apparent redundancy (gene absence and gene loss), may reflect the need to faithfully recognize a multiplicity of pathogen motifs, commensals and a number of self-antigens. C1 [Ortiz, M.; Zhang, K.; Telenti, A.] Univ Lausanne, Inst Microbiol, Lausanne, Switzerland. [Kaessmann, H.] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland. [Bashirova, A.] USA, Med Res Inst Infect Dis, Lab Mol Immunol, Frederick, MD USA. [Carrington, M.] NCI, SAIC Frederick Inc, Expt Immunol Lab, Canc & Inflammat Program, Frederick, MD 21701 USA. [Quintana-Murci, L.] Inst Pasteur, CNRS, URA3012, Paris, France. RP Telenti, A (reprint author), CHU Vaudois, Inst Microbiol, Bugnon 48, CH-1011 Lausanne, Switzerland. EM amalio.telenti@chuv.ch RI Kaessmann, Henrik/B-4989-2013; OI Quintana-Murci, Lluis/0000-0003-2429-6320 FU Swiss National Science Foundation; Faculty of Biology and Medicine of the University of Lausanne; National Cancer Institute; National Institutes of Health [N01-CO-12400]; Intramural Research Program of the NIH; Center for Cancer Research FX We thank Keith Mansfield and Kuei-Chin Lin from the New England Primate Center, and Charles Buillard and Eugene Chabloz from the Zoo of Servion for materials. This work was funded by the Swiss National Science Foundation and a grant for interdisciplinary research from the Faculty of Biology and Medicine of the University of Lausanne. This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government. This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. NR 32 TC 18 Z9 19 U1 1 U2 7 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 J9 GENES IMMUN JI Genes Immun. PD SEP PY 2008 VL 9 IS 6 BP 483 EP 492 DI 10.1038/gene.2008.40 PG 10 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 344LM UT WOS:000258928500001 PM 18528403 ER PT J AU Bautista, CT Sateren, WB Sanchez, JL Singer, DE Scott, P AF Bautista, Christian T. Sateren, Warren B. Sanchez, Jose L. Singer, Darrell E. Scott, Paul TI Geographic mapping of HIV infection among civilian applicants for United States military service SO HEALTH & PLACE LA English DT Article DE HIV; mapping; spatial; civilian applicant; US military; GIS ID YOUNG-ADULTS; EPIDEMIOLOGY AB We assessed the geographic distribution of HIV infection among civilian applicants for US military service. High smoothed HIV prevalences were observed among white applicants in California, Texas, Florida, New York, and New Jersey, and among African-American applicants in New York, New Jersey, Connecticut, Massachusetts, Washington DC, North and South Carolina, Florida, and California. Three HIV spatial clusters were found among whites: New York/New Jersey, southern California, and in south and central Texas. Among African-Americans, three HIV spatial clusters were found: New York/New Jersey, Washington DC/Virginia, and south and central California. The South accounted for a significant proportion of HIV-infected African-American applicants. Published by Elsevier Ltd. C1 [Bautista, Christian T.; Sateren, Warren B.; Sanchez, Jose L.; Singer, Darrell E.; Scott, Paul] Walter Reed Army Inst Res, US Mil Res Program, Div Retrovirol, Rockville, MD 20850 USA. RP Bautista, CT (reprint author), Walter Reed Army Inst Res, US Mil Res Program, Div Retrovirol, 1 Taft Court,Suite 250, Rockville, MD 20850 USA. EM cbautista@hivresearch.org RI Bautista, Christian/B-2812-2011 NR 18 TC 9 Z9 9 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1353-8292 J9 HEALTH PLACE JI Health Place PD SEP PY 2008 VL 14 IS 3 BP 608 EP 615 DI 10.1016/j.healthplace.2007.10.004 PG 8 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA 294DQ UT WOS:000255384900018 PM 18024132 ER PT J AU Gates, JD Benavides, LC Stojadinovic, A Mittendorf, EA Holmes, JP Carmichael, MG McCall, S Milford, AL Merrill, GA Ponniah, S Peoples, GE AF Gates, J. D. Benavides, L. C. Stojadinovic, A. Mittendorf, E. A. Holmes, J. P. Carmichael, M. G. McCall, S. Milford, A. L. Merrill, G. A. Ponniah, S. Peoples, G. E. TI Monitoring circulating tumor cells in cancer vaccine trials SO HUMAN VACCINES LA English DT Editorial Material DE vaccine; immunotherapy; cancer; HER2/neu; circulating tumor cells ID METASTATIC BREAST-CANCER; COLONY-STIMULATING FACTOR; FOLATE-BINDING-PROTEIN; PROGNOSTIC-FACTOR; PERIPHERAL-BLOOD; CLINICAL-TRIAL; OVARIAN-CANCER; PEPTIDE; HER-2/NEU; IDENTIFICATION AB The presence of circulating tumor cells (CTC) from various cancers has provided a wealth of information and possibilities. As the role of CTC detection in the treatment assessment of metastatic breast cancer becomes standard, there is interest in applying this tool in cancer vaccine development and clinical trial monitoring. Since we lack a proven immunologic assay that correlates with clinical response, CTC detection, quantification and phenotypic characterization may be a useful surrogate for clinical outcome. The Cancer Vaccine Development Program is involved in the development of HER2/neu peptide based vaccine development for the prevention of recurrence in HER2/neu expressing cancers like breast cancer. The CellSearch System (Veridex, LLC, Warren, NJ) has been used by our lab in conjunction with in vivo and/or in vitro immunologic measurements to define a monitoring tool that could predict clinical response. Once validated, this assay could significantly shorten clinical trials and lead to more efficient assessment of potentially promising cancer vaccines. C1 [Gates, J. D.; Benavides, L. C.; Peoples, G. E.] Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, Ft Sam Houston, TX 78234 USA. [Stojadinovic, A.; Carmichael, M. G.; Ponniah, S.] Uniformed Serv Univ Hlth Sci, Dept Surg, US Mil Canc Inst, Canc Vaccine Dev Program, Bethesda, MD 20814 USA. [Mittendorf, E. A.] UTMD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX USA. [Holmes, J. P.] USN, San Diego Med Ctr, Div Hematol & Med Oncol, Dept Med, San Diego, CA 92152 USA. [Carmichael, M. G.] Walter Reed Army Med Ctr, Dept Med, Hematol & Med Oncol Serv, Washington, DC 20307 USA. [McCall, S.; Milford, A. L.; Merrill, G. A.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA. RP Peoples, GE (reprint author), Brooke Army Med Ctr, Dept Surg, Gen Surg Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM george.peoples@amedd.army.mil NR 40 TC 6 Z9 8 U1 0 U2 2 PU LANDES BIOSCIENCE PI AUSTIN PA 1002 WEST AVENUE, 2ND FLOOR, AUSTIN, TX 78701 USA SN 1554-8619 J9 HUM VACCINES JI Hum. Vaccines PD SEP-OCT PY 2008 VL 4 IS 5 BP 389 EP 392 PG 4 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 354KK UT WOS:000259638300013 PM 18437056 ER PT J AU Choi, KK Jhabvala, MD Peralta, RJ AF Choi, Kwong-Kit Jhabvala, Murzy D. Peralta, Richard J. TI Voltage-tunable two-color corrugated-QWIP focal plane arrays SO IEEE ELECTRON DEVICE LETTERS LA English DT Article DE infrared detectors; infrared image sensors; quantum wells ID SUPERLATTICES AB We demonstrated a 256 x 256 voltage-tunable two-color corrugated quantum-well infrared-photodetector focal plane array. The detector operation is based on photocurrent asymmetry in a double-superlattice quantum well structure. By using a broad-band corrugated light coupling scheme, we obtained a quantum efficiency of 24% in the mid-wave (MW) band and 26% in the long-wave (LW) band without AR coating. Operating at 50 K, the measured noise equivalent temperature difference is 27 mK at 33-ms integration time for the MW and 90 mK at 2 ms for the LW with 172.44 optics. The NETD operability values are 98.4% and 95.9%, respectively. C1 [Choi, Kwong-Kit] USA, Res Lab, Adelphi, MD 20783 USA. [Jhabvala, Murzy D.] NASA, Goddard Space Flight Ctr, Greenbelt, MD 20771 USA. [Peralta, Richard J.] Raytheon Vis Syst, Goleta, CA 93105 USA. RP Choi, KK (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM kchoi@arl.army.mil; Murzy.D.Jhabvala@nasa.gov; rjperalta@raytheon.com RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 5 Z9 5 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD SEP PY 2008 VL 29 IS 9 BP 1011 EP 1013 DI 10.1109/LED.2008.2001248 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA 353MZ UT WOS:000259573400013 ER PT J AU Chen, C Wang, Y Tan, CL Djie, HS Ooi, BS Hwang, JCM Dang, GT Chang, WH AF Chen, C. Wang, Y. Tan, C. L. Djie, H. S. Ooi, B. S. Hwang, J. C. M. Dang, G. T. Chang, W. H. TI Effects of Intermixing on Gain and Alpha Factors of Quantum-Dash Lasers SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE Diffusion processes; gain measurement; quantum dots; quantum-well lasers; quantum wells; quantum wires; semiconductor lasers AB Gain and alpha factors were measured on InAs-InAlGaAs quantum-dash lasers with their heterostructures intermixed by either a dielectric-capping or ion-implantation technique. The laser intermixed by the dielectric-capping technique exhibits a blue shift as much as 93 nm without degrading the laser quality. In comparison, the laser intermixed by the ion-implantation technique has a larger shift but lower differential gain and higher alpha factor. The result implies that quantum-dash lasers of different wavelengths can be effectively integrated on the same chip by the dielectric-capping intermixing technique. C1 [Chen, C.; Wang, Y.; Tan, C. L.; Djie, H. S.; Ooi, B. S.; Hwang, J. C. M.] Lehigh Univ, Bethlehem, PA 18015 USA. [Dang, G. T.; Chang, W. H.] Army Res Lab, Adelphi, MD 20783 USA. RP Chen, C (reprint author), Lehigh Univ, Bethlehem, PA 18015 USA. EM chc605@lehigh.edu RI Ooi, Boon/D-4370-2011 OI Ooi, Boon/0000-0001-9606-5578 FU National Science Foundation (NSF) [0725647US]; Army Research Laboratory [W911NF-07-2-0064] FX This work was supported in part by the National Science Foundation (NSF) under Grant 0725647US, and in part by the Army Research Laboratory under Cooperative Agreement W911NF-07-2-0064. NR 11 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD SEP-OCT PY 2008 VL 20 IS 17-20 BP 1654 EP 1656 DI 10.1109/LPT.2008.2002747 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 361HV UT WOS:000260119600071 ER PT J AU Trope, RL Witt, M Adams, WJ AF Trope, Roland L. Witt, Monique Adams, William J. TI Hardening the target SO IEEE SECURITY & PRIVACY LA English DT Article C1 [Trope, Roland L.] Trope & Schramm LLP, New York City Off, New York, NY USA. [Trope, Roland L.] US Mil Acad, Dept Law, West Point, NY 10996 USA. RP Trope, RL (reprint author), Trope & Schramm LLP, New York City Off, New York, NY USA. EM rolandtrope@mac.com; zevisgirl@yahoo.com; joe.adams@usma.edu NR 10 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD SEP-OCT PY 2008 VL 6 IS 5 BP 77 EP 81 DI 10.1109/MSP.2008.118 PG 5 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 357LQ UT WOS:000259847700029 ER PT J AU Li, L Gaiser, P Albert, MR Long, DG Twarog, EM AF Li, Li Gaiser, Peter Albert, Mary R. Long, David G. Twarog, Elizabeth M. TI WindSat passive microwave polarimetric signatures of the Greenland ice sheet SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article DE Greenland ice sheet; ice; polarimetric microwave radiometry; snow; WindSat ID SURFACE BRIGHTNESS TEMPERATURES; ROUGH SURFACES; SATELLITE DATA; SNOW; RADIOMETER; EMISSION; MELT; CLASSIFICATION; SCATTEROMETER; ACCUMULATION AB WindSat has systematically collected the first global fully polarimetric passive microwave data over both land and ocean. As the first spaceborne polarimetric microwave radiometer, it was designed to measure ocean surface wind speed and direction by including the third and fourth Stokes parameters, which are mostlu related to the asymmetric structures of the ocean surface roughness. Although designed for wind vector retrieval, WindSat data are also collected over land and ice, and this new data has revealed, for the first time, significant land signals in the third and fourth Stokes parameter channels, particularly over Greenland and the Antarctic ice sheets. The third and fourth Stokes parameters show well-defined large azimuth modulations that appear to be correlated with geophysical variations, particularly snow structure, melting, and metamorphism, and have distinct seasonal variation. The polarimetric signatures are relatively weak in the summer and are strongest around spring. This corresponds well,with the formation and erosion of the sastrugi in the dry snow zone and snowmelt in the soaked zone. In this paper, we present the full polarimetric signatures obtained from WindSat over Greenland, and use a simple empirical observation model to quantify, the azimuthal variations of the signatures in space and time. C1 [Li, Li; Gaiser, Peter; Twarog, Elizabeth M.] USN, Res Lab, Washington, DC 20375 USA. [Albert, Mary R.] Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. [Long, David G.] Brigham Young Univ, Microwave Earth Remote Sensing Lab, Ctr Remote Sensing, Provo, UT 84602 USA. RP Li, L (reprint author), USN, Res Lab, Washington, DC 20375 USA. RI Long, David/K-4908-2015; OI Long, David/0000-0002-1852-3972; Albert, Mary/0000-0001-7842-2359 FU Office of Naval Research; NPOESS Integrated Program Office FX Manuscript received February 23, 2007; revised September 4, 2007. This work was supported in part by the Office of Naval Research and in part by the NPOESS Integrated Program Office. NR 50 TC 14 Z9 14 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 2008 VL 46 IS 9 BP 2622 EP 2631 DI 10.1109/TGRS.2008.917727 PG 10 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA 348SY UT WOS:000259231600014 ER PT J AU Charboneau, BC Wang, F van Wyk, JD Boroyevich, D Liang, ZX Scott, EP Tipton, CW AF Charboneau, Bryan C. Wang, Fei van Wyk, Jacobus Daniel Boroyevich, Dushan Liang, Zhenxian Scott, Elaine P. Tipton, C. Wesley TI Double-sided liquid cooling for power semiconductor devices using Embedded Power packaging SO IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS LA English DT Article; Proceedings Paper CT 40th Annual Meeting of the IEEE-Industry-Applications-Society CY OCT 02-06, 2005 CL Hong Kong, PEOPLES R CHINA SP IEEE Ind Applicat Soc DE double-sided cooling; forced liquid convection; power density; semiconductor packaging ID HEAT SINK; MODULE; TECHNOLOGY AB This paper presents a double-sided liquid cooling scheme for power MOSFETs using Embedded Power packaging technology. A liquid module test bed has been built to create various convection conditions and is used with 600-V high-current MOSFET-based Embedded Power samples to test the effectiveness and feasibility of the proposed scheme. Compared with single-sided liquid cooling, an improvement of 45% to 60% in thermal resistance is experimentally shown, for Embedded Power with double-sided liquid cooling for a device loss between 5 and 300 W and 0.25 to 4.5 GPM water flow rate. The trend and concept is also validated with physics-based lumped parameter thermal models. C1 [Charboneau, Bryan C.] Univ Maryland, College Pk, MD 20742 USA. [Charboneau, Bryan C.] IIT EVI, Columbia, MD 21046 USA. [Wang, Fei; van Wyk, Jacobus Daniel; Boroyevich, Dushan] Virginia Polytech Inst & State Univ, Bradley Dept Elect & Comp Engn, Ctr Power Elect Syst, Blacksburg, VA 24061 USA. [van Wyk, Jacobus Daniel] Univ Johannesburg, Dept Elect & Elect Engn Sci, ZA-2006 Johannesburg, South Africa. [Liang, Zhenxian] Ford Motor Co, Res & Adv Engn Div, Dearborn, MI 48121 USA. [Scott, Elaine P.] Seattle Pacific Univ, Seattle, WA 98119 USA. [Tipton, C. Wesley] USA, Res Lab, Adelphi, MD 20783 USA. RP Charboneau, BC (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM bcharbon@umd.edu; wangfred@vt.edu; daan@vt.edu; dushan@vt.edu; zliang1@ford.com; scotte@spu.edu; wtipton@arl.army.mil OI Liang, Zhenxian/0000-0002-2811-0944 NR 19 TC 9 Z9 10 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0093-9994 J9 IEEE T IND APPL JI IEEE Trans. Ind. Appl. PD SEP-OCT PY 2008 VL 44 IS 5 BP 1645 EP 1655 DI 10.1109/TIA.2008.2002270 PG 11 WC Engineering, Multidisciplinary; Engineering, Electrical & Electronic SC Engineering GA 353NH UT WOS:000259574200041 ER PT J AU Qu, FZ Duan, DL Yang, LQ Swami, A AF Qu, Fengzhong Duan, Dongliang Yang, Liuqing Swami, Ananthram TI Signaling with imperfect channel state information: A battery power efficiency comparison SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article; Proceedings Paper CT IEEE Military Communications Conference (MILCOM 2007) CY OCT 29-31, 2007 CL Orlando, FL SP IEEE DE battery power efficiency (BPE); imperfect channel state information (CSI); ON-OFF keying (OOK) modulation; pulse-position modulation (PPM); wireless sensor networks (WSNs) ID WIRELESS SENSOR NETWORKS; CUTOFF RATE AB Due to complexity considerations, pulse-based modulations such as pulse position modulation (PPM) and ON-OFF keying (OOK) are well suited for wireless sensor networks (WSNs) since they provide the possibility of carrier-less signaling and, more importantly, noncoherent reception bypassing channel estimation at the receiver. In this paper, we compare PPM and OOK in terms of their battery power efficiencies, using a nonlinear battery model, and under the same bandwidth occupancy, bandwidth efficiency and cutoff rate requirement. Cutoff rate is used as our comparison criterion because it leads to a tractable analysis that is often impossible through direct evaluation of random coding exponent or capacity. In addition, cutoff rate gives a universal expression for both coherent and noncoherent detection by simply setting various channel state information (CSI) qualities. Our system model integrates typical WSN transmission and reception modules with realistic nonlinear battery models. Circuit power consumption, dc-dc converter efficiency, and power amplifier efficiency are also taken into consideration. Our analytical results characterize the signal-to-noise ratio (SNR)-cutoff rate-CSI region where PPM is more power efficient than OOK, and vice versa. We provide an interpretation in terms of the transmission range and symbol set size. Numerical results are also provided to verify the analysis. C1 [Qu, Fengzhong; Duan, Dongliang; Yang, Liuqing] Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. [Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA. RP Qu, FZ (reprint author), Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32611 USA. EM jimqufz@ufl.edu; ddl85@ufl.edu; lqyang@ece.ufl.edu; a.swami@ieee.org RI Qu, Fengzhong/I-5189-2014 OI Qu, Fengzhong/0000-0003-2006-0951 NR 19 TC 7 Z9 7 U1 1 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD SEP PY 2008 VL 56 IS 9 BP 4486 EP 4495 DI 10.1109/TSP.2008.924142 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA 341DO UT WOS:000258694600033 ER PT J AU White, LA Young, MC Hunter, AE Rumsey, MG AF White, Leonard A. Young, Mark C. Hunter, Arwen E. Rumsey, Michael G. TI Lessons Learned in Transitioning Personality Measures From Research to Operational Settings SO INDUSTRIAL AND ORGANIZATIONAL PSYCHOLOGY-PERSPECTIVES ON SCIENCE AND PRACTICE LA English DT Article C1 [White, Leonard A.; Young, Mark C.; Rumsey, Michael G.] USA, Res Inst Behav & Social Sci, Arlington, VA 22202 USA. [Hunter, Arwen E.] George Washington Univ, Washington, DC 20052 USA. RP White, LA (reprint author), USA, Res Inst Behav & Social Sci, 2511 Jefferson Davis Highway, Arlington, VA 22202 USA. EM len.white@cox.net NR 10 TC 10 Z9 10 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1754-9426 J9 IND ORGAN PSYCHOL-US JI Ind. Organ. Psychol. PD SEP PY 2008 VL 1 IS 3 BP 291 EP 295 DI 10.1111/j.1754-9434.2008.00049.x PG 5 WC Psychology, Applied SC Psychology GA V16ZI UT WOS:000207907100003 ER PT J AU Buchheit, AA Fahrenholtz, WG Hilmas, GE Deason, DM Wang, H AF Buchheit, Andrew A. Fahrenholtz, William G. Hilmas, Greg E. Deason, Doug M. Wang, H. TI Thermal properties of a reaction hot pressed Mo <= 5Si3C <= 1 ceramic SO INTERMETALLICS LA English DT Article DE molybdenum silicides; thermal properties; reaction synthesis ID MECHANICAL-PROPERTIES; SIC-MO-LESS-THAN-OR-EQUAL-TO-5SI3C-LESS-THAN-OR-EQUAL-TO-1 COMPOSITES; PHASE; BEHAVIOR AB Mo <= 5Si3C <= 1 was produced via reaction hot pressing. X-ray diffraction analysis revealed c-axis crystallographic orientation in the hot pressing direction. The orientation, combined with the inherent thermal expansion anisotropy of the structure, led to preferential microcracking and an overall anisotropic thermal expansion in hot pressed ceramics. Thermal conductivity was calculated for temperatures ranging from - 120 to 500 degrees C from measured heat capacity and thermal diffusivity. Over that range, thermal conductivity increased from similar to 9.5 to similar to 21.5 W/m K. Electrical resistivity measurements allowed the separation of electrical and phononic contributions and revealed that the thermal conductivity of Mo <= 5Si3C <= 1 was dominated by electron transport. (C) 2008 Published by Elsevier Ltd. C1 [Buchheit, Andrew A.; Fahrenholtz, William G.; Hilmas, Greg E.] Univ Missouri Rolla, Mat Sci & Engn Dept, Rolla, MO 65409 USA. [Deason, Doug M.] USA, Space & Missile Def Command, Redstone Arsenal, AL 35898 USA. [Wang, H.] Oak Ridge Natl Lab, High Temp Mat Lab, Oak Ridge, TN 37831 USA. RP Buchheit, AA (reprint author), Coorstek Inc, Golden, CO 80401 USA. EM abuchheit@coorstek.com RI Wang, Hsin/A-1942-2013; OI Wang, Hsin/0000-0003-2426-9867; Fahrenholtz, William/0000-0002-8497-0092 FU Army Space and Missile Defense Command [BAA DASG60-00-0005]; Oak Ridge National Laboratory; Department of Energy [AC05000OR22725]; Areas of National Need (GAANN) FX This work was Supported by the Army Space and Missile Defense Command under grant number BAA DASG60-00-0005 and in part by the Assistant Secretary for Energy Efficiency and Renewable Energy, Office of Transportation Technologies as part of the High Temperature Materials Laboratory User Program at Oak Ridge National Laboratory managed by the UT-Battelle LLC, for the Department of Energy under contract DE-AC05000OR22725. Financial support for A. Buchheit was provided by the Department of Education under the Graduate Assistance in Areas of National Need (GAANN) Fellowship. The authors would also like to thank Ms. Jennifer Gilmore for technical assistance. NR 16 TC 2 Z9 2 U1 0 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0966-9795 J9 INTERMETALLICS JI Intermetallics PD SEP PY 2008 VL 16 IS 9 BP 1047 EP 1052 DI 10.1016/j.intermet.2008.04.021 PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Chemistry; Materials Science; Metallurgy & Metallurgical Engineering GA 357LS UT WOS:000259847900001 ER PT J AU de Bejar, LA Simmons, L Davis, JL AF de Bejar, L. A. Simmons, L. Davis, J. L. TI Standoff-mortar fragment velocity characterization before and after perforating conventional building walls SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE experimental verification of probabilistic models; metal case fragmentation; mortar detonation; residual velocity; wall perforation AB In this work, analytical models are developed to predict mortar-induced impact and residual velocities of case fragments upon interaction with typical building walls. Theoretical models are experimentally verified and the intervening parameters identified. Multiple common structural wall materials are implemented in the experimental verification of statistical models: steel siding, wood studs, concrete masonry units, and solid brick panels. Examples of application lead to the construction of risk curves representing the probability of exceeding a specified threshold value of the residual fragment velocity upon wall perforation. Published by Elsevier Ltd. C1 [de Bejar, L. A.; Simmons, L.; Davis, J. L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP de Bejar, LA (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM luis.a.debejar@erdc.usace.army.mil NR 14 TC 2 Z9 2 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD SEP PY 2008 VL 35 IS 9 BP 1043 EP 1052 DI 10.1016/j.ijimpeng.2007.06.002 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 318MU UT WOS:000257096800009 ER PT J AU de Bejar, LA Davis, JL Simmons, L AF Bejar, L. A. de Davis, J. L. Simmons, L. TI Standoff-mortar-induced fragment forces SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE fragment deceleration; fragment forces on panels; fragment pressure field; metal case fragmentation; mortar detonation AB The mechanical description of the deceleration process of steel case fragments retained in CELOTEX (R) panels in vertical mortar experiments is formulated. Ejected mortar fragments are classified according to their general shape into chunks and fingers and the corresponding probability distributions for linear momentum and weight are inferred. Mortar fragment momentum is beta distributed, whereas fragment weight is a Weibull variate. The equivalent pressure field and the resultant normal force exerted by a rain of flying mortar fragments on transverse panels are modeled. An example illustrates the application of the model using fragment information available either from experimental evidence or from simulation. Published by Elsevier Ltd. C1 [Bejar, L. A. de; Davis, J. L.; Simmons, L.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP de Bejar, LA (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. EM luis.a.debejar@erdc.usace.army.mil NR 15 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD SEP PY 2008 VL 35 IS 9 BP 1053 EP 1062 DI 10.1016/j.ijimpeng.2007.06.003 PG 10 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 318MU UT WOS:000257096800010 ER PT J AU Segletes, SB AF Segletes, Steven B. TI Further development of a model for rod ricochet (vol 34, pg 899, 2007) SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Correction C1 USA, Res Lab, Impact Phys Branch, AMSRD ARL WM TD, Aberdeen Proving Ground, MD 21005 USA. RP Segletes, SB (reprint author), USA, Res Lab, Impact Phys Branch, AMSRD ARL WM TD, Aberdeen Proving Ground, MD 21005 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD SEP PY 2008 VL 35 IS 9 BP 1115 EP 1116 DI 10.1016/j.ijimpeng.2007.06.005 PG 2 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 318MU UT WOS:000257096800015 ER PT J AU Weintrob, AC Fieberg, AM Agan, BK Ganesan, A Crum-Cianflone, NF Marconi, VC Roediger, M Fraser, SL Wegner, SA Wortmann, GW AF Weintrob, Amy C. Fieberg, Ann M. Agan, Brian K. Ganesan, Anuradha Crum-Cianflone, Nancy F. Marconi, Vincent C. Roediger, Mollie Fraser, Susan L. Wegner, Scott A. Wortmann, Glenn W. TI Increasing age at HIV seroconversion from 18 to 40 years is associated with favorable virologic and immunologic responses to HAART SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES LA English DT Article DE age; HIV; highly active antiretroviral therapy (HAART); virologic response; immunologic response; clinical response ID ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS; INFECTED PATIENTS; HIV-1-INFECTED PATIENTS; DISEASE PROGRESSION; OBSERVATIONAL COHORT; ADHERENCE; SURVIVAL; OLDER; AIDS AB Background: Studies evaluating the effect of age on response to highly active antiretroviral therapy (HAART) have been limited by their inability to control for duration of human immunodeficiency virus (HIV) infection. We examined the effect of age at HIV seroconversion on response to HAART. Methods: A retrospective analysis of a longitudinal US military cohort of HIV-infected subjects. Time to and maintenance of viral Suppression, rate of CD4 cell increase, and rate of progression to acquired immunodeficiency syndrome or death were compared across age groups using time-to-event methods. Results: Five hundred sixty-three HIV-infected adults who seroconverted after January 1, 1996, and started HAART were included. Increasing age at seroconversion was significantly associated with faster time to viral Suppression (P = 0.002). Increasing age also correlated with duration Of Suppression, with a 35% reduction in risk of viral rebound for every 5-year increase in age above 18 years (hazard ratio: 0.65, 95% confidence interval 0.55 to 0.75). The rate of CD4 cell increase from 6 to 84 months post-HAART was significantly greater in those who seroconverted at older ages (P = 0.0002). Rates of progression to acquired immunodeficiency syndrome or death did not differ between groups. Conclusions: increasing age at seroconversion was associated with shorter time to and longer maintenance of viral suppression and a faster increase in CD4 cell count. C1 [Weintrob, Amy C.; Fieberg, Ann M.; Agan, Brian K.; Ganesan, Anuradha; Crum-Cianflone, Nancy F.; Marconi, Vincent C.; Roediger, Mollie; Fraser, Susan L.; Wegner, Scott A.; Wortmann, Glenn W.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA. [Weintrob, Amy C.; Wortmann, Glenn W.] Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. [Fieberg, Ann M.; Roediger, Mollie] Univ Minnesota, Coordinating Ctr Biometr Res, Minneapolis, MN USA. [Agan, Brian K.; Marconi, Vincent C.] San Antonio Mil Med Ctr, Dept Med, San Antonio, TX USA. [Ganesan, Anuradha] Natl Naval Med Ctr, Dept Med, Bethesda, MD USA. [Crum-Cianflone, Nancy F.] USN, San Diego Med Ctr, Dept Med, San Diego, CA 92152 USA. [Fraser, Susan L.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA. RP Weintrob, AC (reprint author), Walter Reed Army Med Ctr, Dept Med, 6900 Georgia Ave NW,Bldg 2,Ward 63,Room 6312, Washington, DC 20307 USA. EM amy.weintrob@na.amedd.army.mil RI Marconi, Vincent/N-3210-2014; OI Marconi, Vincent/0000-0001-8409-4689; Agan, Brian/0000-0002-5114-1669 NR 35 TC 36 Z9 37 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1525-4135 J9 JAIDS-J ACQ IMM DEF JI JAIDS PD SEP PY 2008 VL 49 IS 1 BP 40 EP 47 DI 10.1097/QAI.0b013e31817bec05 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 343IW UT WOS:000258847800006 PM 18667932 ER PT J AU Ho, JC Yeo, H Ormiston, RA AF Ho, Jimmy C. Yeo, Hyeonsoo Ormiston, Robert A. TI Investigation of Rotor Blade Structural Dynamics and Modeling Based on Measured Airloads SO JOURNAL OF AIRCRAFT LA English DT Article ID HELICOPTER AB The work presented herein treats measured airloads from the UH-60A Airloads Program as prescribed external loads to calculate the resulting structural loads and motions of a rotor blade. Without the need to perform any aerodynamic computations, the coupled aeroelastic response problem is reduced to one involving only structural dynamics. The results, computed by RCAS and CAMRAD II, are compared against measured results and against each other for three representative test points. The results from the two codes mostly validate each other. Seven more test points, with responses computed by RCAS, to form thrust and airspeed sweeps are evaluated to better understand key issues. One such issue is an inability to consistently predict pushrod loads and torsion moments well, and this is found to be amplified at the two test points with the highest thrust coefficient. For these two test points, harmonic analysis reveals that the issue is due to excessive amounts of 5/rev response that stem from high levels of 5/rev pitching moment excitation. Another issue that concerns all test points is that the phase of the 1/rev blade flapping motion is not predicted well, which reflects the high sensitivity of this quantity that is developed due to having a first flap frequency of approximately 1/rev. Results also show that current force-velocity relationships, used in describing the lead-lag damper, are not satisfactory to consistently yield accurate inboard chordwise bending moment predictions. Overall, the investigation here, conducted with numerous test points, further confirms the methodology of prescribing measured airloads for assessing the structural dynamics capability of a computational tool. C1 [Ho, Jimmy C.] Georgia Inst Technol, Guggenheim Sch Aerosp Engn, Atlanta, GA 30332 USA. [Ho, Jimmy C.; Yeo, Hyeonsoo; Ormiston, Robert A.] USA, Res Dev & Engn Command, Aeroflightdynam Directorate AMRDEC, Ames Res Ctr, Moffett Field, CA 94035 USA. RP Ho, JC (reprint author), Georgia Inst Technol, Guggenheim Sch Aerosp Engn, 270 Ferst Dr, Atlanta, GA 30332 USA. EM JHo@gatech.edu NR 16 TC 13 Z9 13 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD SEP-OCT PY 2008 VL 45 IS 5 BP 1631 EP 1642 DI 10.2514/1.34025 PG 12 WC Engineering, Aerospace SC Engineering GA 360RF UT WOS:000260074500017 ER PT J AU Paine, JB Pithawalla, YB Naworal, JD AF Paine, John B., III Pithawalla, Yezdi B. Naworal, John D. TI Carbohydrate pyrolysis mechanisms from isotopic labeling Part 4. The pyrolysis Of D-glucose: The formation of furans SO JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS LA English DT Article DE D-Glucose; D-Fructose; Pyrolysis; Isotopic labeling; Furan; Furfural; Cyclic Grob fragmentation; Isotopolog; Naturalomer; (13)Carbo-ubiquilog ID ELECTROCYCLIC FRAGMENTATION MECHANISMS; COMPETING FRAGMENTATION; THERMAL DECOMPOSITION; CARBONYL-COMPOUNDS; FORMALDEHYDE; FRUCTOSE AB The use of C-13 isotopically labeled D-glucose has led to an improved understanding of the mechanisms of pyrolytic formation of furan and 15 of its derivatives. The cyclic Grob fragmentation of 1,3-diols as applied to D-glucose leads to rationalizations of important observed labeling patterns among the I I furans that resulted from carbon-loss during the pyrolytic sequence. A copyrolysis of (13)carbo-ubiquilog and naturalomer D-glucose established that the preponderance of each of the furans arose in unimolecular fashion. Copyrolysis of (13)carbo-ubiquilog D-glucose and naturalomer D-fructose provided relative product formation ratios consistent with the involvement of fructose in some of the mechanistic pathways. Formation of nine of the furans from D-glucose (furfural, 5-hydroxymethylfurfural, furan, 3-[2H]-furanone, hydroxymethyl furyl ketone, furfuryl alcohol, alpha-angelica lactone, "Miyazaki's substance", and furan-3-carboxaldehyde) can be rationalized without need to invoke oxidation-reduction steps. Prospective mechanistic schemes are presented for most of these. Six of the furans (5-methylfurfural, 2-methylfuran, 3-methylfuran, 2,5-dimethylfuran, 2-(1,2-dihydroxyethyl)furan, and butyrolactone) need the intervention of redox chemistry to account for their formation, and their relation to similar products that can form without need for redox chemistry is discussed. (C) 2008 Elsevier B.V. All rights reserved. C1 [Paine, John B., III; Pithawalla, Yezdi B.; Naworal, John D.] Philip Morris Inc, USA, Res Ctr, Richmond, VA 23261 USA. RP Paine, JB (reprint author), Philip Morris Inc, USA, Res Ctr, POB 26583, Richmond, VA 23261 USA. EM John.B.Paine@pmusa.com NR 32 TC 60 Z9 72 U1 5 U2 55 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2370 EI 1873-250X J9 J ANAL APPL PYROL JI J. Anal. Appl. Pyrolysis PD SEP PY 2008 VL 83 IS 1 BP 37 EP 63 DI 10.1016/j.jaap.2008.05.008 PG 27 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA 363MD UT WOS:000260270500005 ER PT J AU Schulmeister, K Husinsky, J Seiser, B Edthofer, F Fekete, B Farmer, L Lund, DJ AF Schulmeister, Karl Husinsky, Johannes Seiser, Bernhard Edthofer, Florian Fekete, Beate Farmer, Letizia Lund, David J. TI Ex vivo and computer model study on retinal thermal laser-induced damage in the visible wavelength range SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE laser safety; retinal thermal damage; damage threshold; computer model; ANSI Z136.1; IEC 60825-1 ID THRESHOLDS; EXPOSURE; LIMITS AB Excised bovine eyes are used as models for threshold determination of 532-nm laser-induced thermal damage of the retina in the pulse duration regime of 100 mu s to 2 s for varying laser spot size diameters. The thresholds as determined by fluorescence viability staining compare well with the prediction of an extended Thompson-Gerstman computer model. Both models compare well with published Rhesus monkey threshold data. A previously unknown variation of the spot size dependence is seen for different pulse durations, which allows for a more complete understanding of the retinal thermal damage. Current International Commission on Nonionized Radiation Protection (ICNIRP), American National Standards Institute (ANS), and International Electromechanical Commission (IEC) laser and incoherent optical radiation exposure limits can be increased for extended sources for pulsed exposures. We conclude that the damage mechanism at threshold detected at 24 and 1 h for the nonhuman primate model is retinal pigment epithelium (RPE) cell damage and not thermal coagulation of the sensory retina. This work validates the bovine ex vivo and computer models for prediction of thresholds of thermally induced damage in the time domain of 10 mu s to 2 s, which provides the basis for safety analysis of more complicated retinal exposure scenarios such as repetitive pulses, nonconstant retinal irradiance profiles, and scanned exposure. (C) 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.2982526] C1 [Schulmeister, Karl; Husinsky, Johannes; Seiser, Bernhard; Edthofer, Florian] Austrian Res Ctr GmbH, Austrian Res Ctr, A-2444 Seibersdorf, Austria. [Fekete, Beate; Farmer, Letizia] Austrian Res Ctr GmbH, Dept Toxicol, A-2444 Seibersdorf, Austria. [Lund, David J.] USA, Walter Reed Army Inst Res, Brooks City Base, TX 78235 USA. RP Schulmeister, K (reprint author), Austrian Res Ctr GmbH, Austrian Res Ctr, Laser & Opt Radiat Test House, A-2444 Seibersdorf, Austria. EM karl.schulmeister@arcs.ac.at FU U. S. Army Center of Health Promotion and Medicine, Baltimore; U. S. Army Research Detachment, San Antonio FX The authors gratefully acknowledge the help and support of the following individuals: David Sliney (U. S. Army Center of Health Promotion and Medicine, Baltimore) and Bruce Stuck (U. S. Army Research Detachment, San Antonio) for frequent and fruitful discussions; Boris Povazay of Cardiff University for information provided on high resolution OCT; Paul Kennedy (U. S. Air Force Research Lab, San Antonio) for help in the initial phases of realizing the Thompson-Gerstman model; Donna Clarkson (Northrop Grumman, San Antonio) for preparing histological micrographs; Clemens Alt (Wellman Center for Photomedicine, Harvard Medical School) for demonstrating the ex vivo sample preparation method; and Astrid Hrdina (Austrian Research Centers, Toxicology Department) for help with dissecting the cow eyes. NR 22 TC 13 Z9 13 U1 0 U2 3 PU SPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 J9 J BIOMED OPT JI J. Biomed. Opt. PD SEP-OCT PY 2008 VL 13 IS 5 AR 054038 DI 10.1117/1.2982526 PG 13 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 384SQ UT WOS:000261764900047 PM 19021418 ER PT J AU Vincelette, RL Welch, AJ Thomas, RJ Rockwell, BA Lund, DJ AF Vincelette, Rebecca L. Welch, Ashley J. Thomas, Robert J. Rockwell, Benjamin A. Lund, David J. TI Thermal lensing in ocular media exposed to continuous-wave near-infrared radiation: the 1150-1350-nm region SO JOURNAL OF BIOMEDICAL OPTICS LA English DT Article DE thermal lensing; ocular damage; near infrared; laser tissue interaction; damage mechanisms; action spectrum ID RETINAL-DAMAGE THRESHOLD; WAVELENGTH DEPENDENCE; LASER IRRADIATION; RABBIT RETINA; SCHEMATIC EYE; YAG LASER; INJURY; ABSORPTION; IR; TEMPERATURES AB Ocular damage threshold data remain sparse in the continuous wave (CW), near-infrared (NIR) radiation region save for the 1300-nm area that has been investigated in the past several decades. The 1300-nm ocular damage data have yielded unusual characteristics where CW retinal damage was observed in rabbit models, but never in nonhuman primate models. This paper reviews the existing 1300-nm ocular damage threshold data in terms of the fundamental criteria of an action spectrum to assist in explaining laser-tissue effects from near-infrared radiation in the eye. Reviewing the action spectrum criteria and existing NIR retinal lesion data lend evidence toward the significant presence of thermal lensing in ocular media affecting damage, a relatively unexplored mechanism of laser-tissue interaction. (C) 2008 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.2978066] C1 [Vincelette, Rebecca L.; Welch, Ashley J.] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA. [Thomas, Robert J.; Rockwell, Benjamin A.] USAF, Res Lab, Human Effectiveness Directorate Opt, Brooks AFB, TX 78235 USA. [Lund, David J.] USA, Med Res Detachment, Brooks AFB, TX 78235 USA. RP Vincelette, RL (reprint author), Univ Texas Austin, Dept Biomed Engn, 1 Univ Stn,C0800, Austin, TX 78712 USA. EM rebecca.vincelette@gmail.com NR 71 TC 22 Z9 24 U1 1 U2 1 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 1083-3668 EI 1560-2281 J9 J BIOMED OPT JI J. Biomed. Opt. PD SEP-OCT PY 2008 VL 13 IS 5 AR 054005 DI 10.1117/1.2978066 PG 10 WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine & Medical Imaging SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine & Medical Imaging GA 384SQ UT WOS:000261764900014 PM 19021385 ER PT J AU Aragon, AB Jackson, WM Onodera, J Tuan, RS Nesti, LJ AF Aragon, A. B. Jackson, W. M. Onodera, J. Tuan, R. S. Nesti, L. J. TI Gene Expression in Blast-Injured Muscle: Insights into the Mechanism of Heterotopic Ossification. SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT 30th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY SEP 12-16, 2008 CL Montreal, CANADA SP Amer Soc Bone & Mineral Res C1 [Aragon, A. B.; Nesti, L. J.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Jackson, W. M.; Onodera, J.; Tuan, R. S.] NIAMSD, Cartilage Biol & Orthopaed Branch, Bethesda, MD 20892 USA. RI Onodera, Jun/D-7142-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC BONE & MINERAL RES PI WASHINGTON PA 2025 M ST, N W, STE 800, WASHINGTON, DC 20036-3309 USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD SEP PY 2008 VL 23 BP S281 EP S281 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 351FX UT WOS:000259411001428 ER PT J AU Crane, DP Gromov, K Murray, CK O'Keefe, RJ Schwarz, EM AF Crane, D. P. Gromov, K. Murray, C. K. O'Keefe, R. J. Schwarz, E. M. TI Colistin-Impregnated Bone Cement Beads Prevent Multi-Drug Resistant Acinetobacter Osteomyelitis. SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT 30th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY SEP 12-16, 2008 CL Montreal, CANADA SP Amer Soc Bone & Mineral Res C1 [Crane, D. P.; Gromov, K.; O'Keefe, R. J.; Schwarz, E. M.] Univ Rochester, Rochester, NY USA. [Murray, C. K.] Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC BONE & MINERAL RES PI WASHINGTON PA 2025 M ST, N W, STE 800, WASHINGTON, DC 20036-3309 USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD SEP PY 2008 VL 23 BP S432 EP S432 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 351FX UT WOS:000259411002373 ER PT J AU Roesel, TR AF Roesel, T. R. TI A Novel Hypothesis Explains the Syndrome of Chronic Musculoskeletal Pain and Comorbid Painful Healed Fracture Sites in Vitamin D Deficiency SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract CT 30th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research CY SEP 12-16, 2008 CL Montreal, CANADA SP Amer Soc Bone & Mineral Res C1 Walter Reed Army Med Ctr, Deployment Hlth Clincal Ctr, Washington, DC 20307 USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU AMER SOC BONE & MINERAL RES PI WASHINGTON PA 2025 M ST, N W, STE 800, WASHINGTON, DC 20036-3309 USA SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD SEP PY 2008 VL 23 BP S223 EP S223 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 351FX UT WOS:000259411001197 ER PT J AU DePolo, DS Linzell, DG AF DePolo, David S. Linzell, Daniel G. TI Evaluation of live-load lateral flange bending distribution for a horizontally curved I-girder bridge SO JOURNAL OF BRIDGE ENGINEERING LA English DT Article DE live-load; bending; bridges; curvature; bridges; girder; load distribution; numerical models AB This paper focuses on levels of live-load lateral bending moment (bimoment) distribution in a horizontally curved steel I-girder bridge. Work centered primarily on the examination of (1) data from field testing of an in-service horizontally curved steel I-girder bridge and (2) results from a three-dimensional numerical model. Experimental data sets were used for calibration of the numerical model and the calibrated model was then used to examine the accuracy of lateral bending distribution factor equations presented in the 1993 Edition of the (AASHTO) Guide Specifications for Horizontally Curved Bridges. It is of interest to examine these equations for potential use in preliminary design even though they have been eliminated during recent AASHTO specification modifications that addressed curved bridge analysis, the 2005 Interims to the AASHTO LRFD Bridge Design Specifications. In addition, they were developed using idealized computer models and small-scale laboratory testing with very few field tests of in-service full-scale curved steel bridges conducted to support or refute their use. Results from such experimental and numerical studies are presented and discussed herein. C1 [DePolo, David S.] USA, Corps Engineers, Sacramento, CA 95815 USA. [Linzell, Daniel G.] Penn State Univ, Dept Civil & Environm Engn, University Pk, PA 16802 USA. RP DePolo, DS (reprint author), USA, Corps Engineers, GS11, Sacramento, CA 95815 USA. NR 19 TC 3 Z9 3 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0702 J9 J BRIDGE ENG JI J. Bridge Eng. PD SEP-OCT PY 2008 VL 13 IS 5 BP 501 EP 510 DI 10.1061/(ASCE)1084-0702(2008)13:5(501) PG 10 WC Engineering, Civil SC Engineering GA 338DD UT WOS:000258484600010 ER PT J AU Endorf, FW Cancio, LC Gibran, NS AF Endorf, Frederick W. Cancio, Leopoldo C. Gibran, Nicole S. TI Toxic epidermal necrolysis clinical guidelines SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID STEVENS-JOHNSON-SYNDROME; INTRAVENOUS IMMUNOGLOBULIN; BURN CENTER; ERYTHEMA MULTIFORME; AMNIOTIC MEMBRANE; SYSTEMIC SYMPTOMS; DRESS SYNDROME; SCORTEN; MANAGEMENT; MORTALITY C1 [Endorf, Frederick W.; Cancio, Leopoldo C.; Gibran, Nicole S.] Univ Washington, Harborview Med Ctr, Seattle, WA 98104 USA. [Cancio, Leopoldo C.] Univ Washington, USA, Inst Surg Res, Seattle, WA 98104 USA. RP Endorf, FW (reprint author), Univ Washington, Harborview Med Ctr, 325 9th Ave, Seattle, WA 98104 USA. NR 60 TC 31 Z9 32 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X EI 1559-0488 J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2008 VL 29 IS 5 BP 706 EP 712 DI 10.1097/BCR.0b013e3181848bb1 PG 7 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 347RO UT WOS:000259158900004 PM 18695603 ER PT J AU Mann, EA Pidcoke, HF Salinas, J Holcomb, JB Wolf, SE Wade, CE AF Mann, Elizabeth A. Pidcoke, Heather F. Salinas, Jose Holcomb, John B. Wolf, Steven E. Wade, Charles E. TI The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID CRITICALLY-ILL PATIENTS; POINT-OF-CARE; INFECTION; ANEMIA; MULTICENTER; MANAGEMENT; CHILDREN; METERS; INJURY; RATES AB The prevalence of intensive insulin and restrictive blood use protocols in burn centers is unknown, which may be problematic as the combined impact of these therapies is to concomitantly increase the prevalence of anemia and hypoglycemia in intensive care unit patients. Such a development is important because point-of-care (POC) glucometers report erroneously high values in the presence of low hematocrit (HCT), potentially masking the presence of hypoglycemia. We hypothesized that most American Burn Association (ABA) verified burn centers have adopted intensive insulin therapy while simultaneously restricting blood transfusions potentially increasing risk of hypoglycemia. All ABA verified burn centers (N = 44) were contacted. Clinical practices regarding intensive insulin therapy, restrictive transfusion practices, and the use of POC glucometers were evaluated. Intensive insulin protocols were implemented at 73% of ABA centers (defined as upper glucose target of <= 120 mg/dl) and POC glucometers measurement was nearly universal; 95% of ABA centers use them routinely. Anemia is prevalent in intensive care units and may be increasing because of recent changes in practice. Defined hemoglobin and HCT levels trigger blood transfusion at 84% of centers, and of these, 51% restrict transfusion to hemoglobin <7 g/dl or HCT <22%. Most ABA centers now use intensive insulin protocols, many in combination with restrictive transfusion strategies. The combination of a higher prevalence of hypoglycemia in the presence of near universal anemia is concerning, particularly given the pervasiveness of glucometer use among burn centers. C1 [Mann, Elizabeth A.; Pidcoke, Heather F.; Salinas, Jose; Holcomb, John B.; Wolf, Steven E.; Wade, Charles E.] USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. RP Mann, EA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 FU The National Institutes of Health [1 R01 GM063120-04]; The Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund FX This study was supported by The National Institutes of Health (1 R01 GM063120-04); The Technologies for Metabolic Monitoring (TMM)/Julia Weaver Fund, A Congressionally Directed Program Jointly Managed by the USA MRMC, NIH, NASA; and the Juvenile Diabetes Research Foundation and Combat Casualty Care Division United States Army Medical Research and Material Command. NR 41 TC 9 Z9 9 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2008 VL 29 IS 5 BP 718 EP 723 DI 10.1097/BCR.0b013e3181848c74 PG 6 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 347RO UT WOS:000259158900006 PM 18825791 ER PT J AU Chapman, TT Richard, RL Hedman, TL Chisholm, GB Quick, CD Baer, DG Dewey, WS Jones, JS Renz, EM Barillo, DJ Cancio, LC Chung, KK Holcomb, JB Wolf, SE AF Chapman, Ted T. Richard, Reg L. Hedman, Travis L. Chisholm, Gary B. Quick, Charles D. Baer, David G. Dewey, William S. Jones, John S. Renz, Evan M. Barillo, David J. Cancio, Leopold C. Chung, Kevin K. Holcomb, John B. Wolf, Steven E. TI Military return to duty and civilian return to work factors following burns with focus on the hand and literature review SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article ID INJURY; IMPAIRMENT; EMPLOYMENT AB Functional recovery and outcome from severe burns is oftentimes judged by the time required for a person to return to work (RTW) in civilian life. The equivalent in military terms is return to active duty. Many factors have been described in the literature as associated with this outcome. Hand function, in particular, is thought to have a great influence on the resumption of preburn activities. The purpose of this investigation was to compare factors associated with civilian RTW with combat injured military personnel. A review of the literature was performed to assimilate the many factors reported as involved with RTW or duty. Additionally, a focus on the influence of hand burns is included. Thirty-four different parameters influencing RTW have been reported inconsistently in the literature. In a military population of combat burns, TBSA burn, length of hospitalization and intensive care and inhalation injury were found as the most significant factors in determining return to duty status. In previous RTW investigations of civilian populations, there exists a scatter of factors reported to influence patient disposition with a mixture of conflicting results. In neither military nor civilian populations was the presence of a hand burn found as a dominant factor. Variety in patient information collected and statistical approaches used to analyze this information were found to influence the results and deter comparisons between patient populations. There is a need for a consensus data set and corresponding statistical approach used to evaluate RTW and duty outcomes after burn injury. C1 [Richard, Reg L.] USA, Inst Surg Res, ATTN MCMR USC PT, Ft Sam Houston, TX 78234 USA. [Chisholm, Gary B.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX USA. RP Richard, RL (reprint author), USA, Inst Surg Res, ATTN MCMR USC PT, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 20 TC 15 Z9 15 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD SEP-OCT PY 2008 VL 29 IS 5 BP 756 EP 762 DI 10.1097/BCR.0b013e3181848b41 PG 7 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 347RO UT WOS:000259158900011 PM 18695607 ER PT J AU Edwards, JD Burka, JM Bower, KS Stutzman, RD Sediq, DA Rabin, JC AF Edwards, Jayson D. Burka, Jenna M. Bower, Kraig S. Stutzman, Richard D. Sediq, Denise A. Rabin, Jeff C. TI Effect of brimonidine tartrate 0.15% on night-vision difficulty and contrast testing after refractive surgery SO JOURNAL OF CATARACT AND REFRACTIVE SURGERY LA English DT Article ID IN-SITU KERATOMILEUSIS; LASER PHOTOREFRACTIVE KERATECTOMY; CORNEAL OPTICAL ABERRATIONS; PUPIL SIZE; SENSITIVITY; GLARE; DISTURBANCES; SATISFACTION; CLEARANCE; MYOPIA AB PURPOSE: To evaluate the efficacy of brimonidine tartrate ophthalmic solution 0.15% in patients with night-vision difficulties after laser refractive surgery. SETTING: Center for Refractive Surgery, Walter Reed Army Medical Center, Washington, District of Columbia, USA. METHODS: Six patients with significant night-vision complaints after refractive surgery were enrolled in this study after other treatable causes of night-vision difficulty such as residual refractive error and dry eye were excluded. Low-contrast visual acuity (LCVA) over a range of contrasts (1.25% to 25%) and small letter contrast sensitivity were tested at photopic (100 cd/m(2)) and mesopic (1 cd/m(2)) luminance levels, with and without a standard glare source. Testing was performed before brimonidine tartrate ophthalmic solution 0.15% was administered. Measurements were repeated 1 hour and 1 month after the use of brimonidine tartrate. RESULTS: One hour after using brimonidine tartrate 0.15% solution, patients had significant improvement in LCVA, LCVA with glare, and contrast sensitivity. After 1 month of treatment, all 6 patients reported subjective improvement in night vision and there was a significant difference in performance in mesopic LCVA and mesopic LCVA with glare. The mean pupil size before administration of brimonidine tartrate ophthalmic solution 0.15% was 6.44 mm +/-1.11 (SD). Pupil size 1 hour after instillation had decreased to 4.53 +/- 1.27 mm and at 1 month had increased to 6.50 +/- 0.94 mm. CONCLUSION: Brimonidine tartrate ophthalmic solution 0.15% improved contrast sensitivity and acuity and decreased night-vision difficulty for up to 1 month in patients with significant complaints after refractive surgery. C1 [Rabin, Jeff C.] Brooks City Base, San Antonio, TX USA. [Burka, Jenna M.] Georgetown Univ, Washington Hosp Ctr, Dept Ophthalmol, Washington, DC USA. [Edwards, Jayson D.] Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Washington, DC 20307 USA. RP Edwards, JD (reprint author), Walter Reed Army Med Ctr, Ctr Refract Surg, Ophthalmol Serv, Room 2F-200,6900 Georgia Ave NW, Washington, DC 20307 USA. EM jayson.edwards@amedd.army.mil NR 25 TC 7 Z9 8 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0886-3350 J9 J CATARACT REFR SURG JI J. Cataract. Refract. Surg. PD SEP PY 2008 VL 34 IS 9 BP 1538 EP 1541 DI 10.1016/j.jcrs.2008.05.029 PG 4 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 346EK UT WOS:000259051100023 PM 18721716 ER PT J AU Shi, XR Garcia, GE Nambiar, MP Gordon, RK AF Shi, Xuerong Garcia, Gregory E. Nambiar, Madhusoodana P. Gordon, Richard K. TI Un-nicked BoNT/B activity in human SHSY-5Y neuronal cells SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE botulinum neurotoxin; synaptobrevin-2; bacterial toxin; synapse; vesicle cellular trafficking; endocytosis; proteasome ID NEUROTOXIN TYPE-A; INTERCHAIN DISULFIDE BOND; BOTULINUM NEUROTOXIN; NEUROTRANSMITTER RELEASE; LIGHT-CHAINS; TOXIN; TETANUS; HEAVY; TRANSLOCATION; SEPARATION AB BoNT/B holotoxin (HT) from the native source is a mixture of nicked and un-nicked forms. A previous study showed that while un-nicked FIT could be transcytosed by intestinal epithelial cells, they did not correlate this with proteolytic activity or biological effect(s). Un-nicked FIT is likely to be present in BoNT biological warfare agents (BWA), so it is important to investigate the relative toxicity of un-nicked HT in this BWA. To address this issue, we purified un-nicked HT from commercial sources and evaluated its ability to cleave substrates both in vitro and in vivo, and its effects on vesicle trafficking. The un-nicked HT was unable to cleave VAMPTide(TM) substrate used for in vitro proteolytic assays. Brief digestion of the un-nicked toxin with trypsin resulted in significant activation of the toxin proteolytic ability. SHSY-5Y human neuroblastoma cells were used to examine HT uptake and activation in vivo. Vesicle trafficking can be measured following K-(+)stimulation of cells preloaded with [H-3]-noradrenaline (NA). We found that highly purified un-nicked FIT did inhibit NA release but at much reduced levels compared to the nicked toxin. That: the reduction in NA release was due to BoNT effects on SNARE proteins was supported by the finding that VAMP-2 protein levels in un-nicked toxin treated cells was greater than those treated with nicked toxin. These results demonstrate that although un-nicked HT has markedly reduced toxicity than the nicked form, due to the preponderance in BoNT/B preparations from the native bacteria, it is a major source of toxicity. C1 [Shi, Xuerong; Garcia, Gregory E.; Nambiar, Madhusoodana P.; Gordon, Richard K.] Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, Silver Spring, MD 20910 USA. RP Shi, XR (reprint author), Walter Reed Army Inst Res, Dept Biochem Pharmacol, Div Biochem, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM xuerong.shi@amedd.army.mil FU Defense Threat Reduction Agency (DTRA) [3.10017_06_WR_B] FX Grant sponsor: Defense Threat Reduction Agency (DTRA); Grant number: #3.10017_06_WR_B. NR 35 TC 4 Z9 4 U1 1 U2 4 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD SEP 1 PY 2008 VL 105 IS 1 BP 129 EP 135 DI 10.1002/jcb.21800 PG 7 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 346ZX UT WOS:000259109200015 PM 18459116 ER PT J AU Furusato, B Rosner, IL Osborn, D Ali, A Srivastava, S Davis, CJ Sesterhenn, IA McLeod, DG AF Furusato, B. Rosner, I. L. Osborn, D. Ali, A. Srivastava, S. Davis, C. J. Sesterhenn, I. A. McLeod, D. G. TI Do patients with low volume prostate cancer have prostate specific antigen recurrence following radical prostatectomy? SO JOURNAL OF CLINICAL PATHOLOGY LA English DT Article ID PREOPERATIVE PREDICTION; SYSTEMATIC BIOPSIES; SPECIMENS; STAGE; MEN; TUMORS; RISK AB Aims: The objective of this study was to determine the incidence of prostate specific antigen (PSA) relapse in patients with low volume prostate cancer following radical prostatectomy. Methods: Between 1993 and 2001, 50 of 717 patients had total tumour volumes of less than 0.5 cm(3) following radical prostatectomy. Biochemical recurrence was defined as two consecutive values of serum PSA levels of 0.2 ng/ml or greater. Results: Median follow-up of the 50 patients was 58 months. In five of the 50 patients (10%), PSA recurrence was observed. All of these five cases had Gleason score of 3+3 (well and/or moderately differentiated), organ confined and surgical margin negative tumours. In three of the five cases, capsular incision resulted in benign glands extending into the surgical margin. Conclusions: Five of 50 cases had PSA failure. In three of the five patients, benign glands located in the margin could explain the "PSA recurrence". However, in the other two patients, none of the pathological parameters correlated with measurable PSA levels. The explanation for their PSA failure is unclear. C1 [Furusato, B.; Davis, C. J.; Sesterhenn, I. A.] Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. [Rosner, I. L.; Osborn, D.; McLeod, D. G.] Walter Reed Army Med Ctr, Dept Surg, Urol Serv, Washington, DC 20307 USA. [Furusato, B.; Ali, A.; Srivastava, S.; McLeod, D. G.] Uniformed Serv Univ Hlth Sci, Ctr Prostate Dis Res, Dept Surg, Bethesda, MD 20814 USA. RP McLeod, DG (reprint author), Ctr Prostate Dis Res, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM dgmcleod@verizon.net OI Furusato, Bungo/0000-0003-4614-9882 FU Henry M Jackson Foundation for the Advancement of Military Medicine [HU001-04-C-1502]; NIH [R01 DK065977] FX This research was supported by the Center for Prostate Disease Research Program through the Henry M Jackson Foundation for the Advancement of Military Medicine under contract number HU001-04-C-1502 and by NIH Grant R01 DK065977 (DM and SS). NR 17 TC 5 Z9 5 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0021-9746 J9 J CLIN PATHOL JI J. Clin. Pathol. PD SEP PY 2008 VL 61 IS 9 BP 1038 EP 1040 DI 10.1136/jcp.2008.057794 PG 3 WC Pathology SC Pathology GA 341ZW UT WOS:000258755400012 PM 18552171 ER PT J AU Statler, J Mammen, M Lyons, A Sun, W AF Statler, John Mammen, Mammen Lyons, Arthur Sun, Wellington TI Sonographic findings of healthy volunteers infected with dengue virus SO JOURNAL OF CLINICAL ULTRASOUND LA English DT Article DE dengue; ultrasound; effusion; abdomen; ascites; pericardial effusion; gallbladder ID HEMORRHAGIC-FEVER; ULTRASOUND AB Purpose. Sonography has historically been used in developing countries to help diagnose dengue infection during epidemics of dengue hemorrhagic fever in endemic areas and to predict the clinical course. In this article, we describe the sonographic findings in subjects infected with attenuated, monovalent strains of dengue virus. Methods. As part of a major research protocol to validate challenge strains of dengue virus for use in vaccines, 12 subjects were infected with 1 of 4 strains of dengue virus, and 3 subjects received placebo. The challenge was followed by an observation period. During this time, they were imaged regardless of the development of symptoms. Results. Seven of 12 subjects infected with dengue virus showed sonographic evidence of subclinical plasma leakage, including perihepatic and perisplenic ascites, pericardial effusion, and gallbladder wall thickening. None of the 3 placebo recipients developed effusions. Conclusion. Sonographic evidence of fluid collection was seen in over half of subjects infected with dengue virus who did not show any evidence of dengue hemorrhagic fever. These findings shed light on possible mechanisms of plasma leakage and its role in the pathogenesis of dengue fever and dengue hemorrhagic fever. (C) 2008 Wiley Periodicals, Inc. C1 [Statler, John] Madigan Army Med Ctr, Dept Radiol, Ft Lewis, WA 98431 USA. [Statler, John] Uniformed Serv Univ Hlth Sci, Dept Radiol & Radiol Sci, Bethesda, MD 20814 USA. [Mammen, Mammen] USAMMDA, Ft Detrick, MD 21702 USA. [Lyons, Arthur; Sun, Wellington] Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD 20910 USA. RP Statler, J (reprint author), Mary Washington Hosp, Dept Radiol, 1001 Sam Perry Blvd, Fredericksburg, VA 22401 USA. RI Lyons, Arthur/B-8923-2011 NR 16 TC 29 Z9 30 U1 0 U2 1 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0091-2751 J9 J CLIN ULTRASOUND JI J. Clin. Ultrasound PD SEP PY 2008 VL 36 IS 7 BP 413 EP 417 DI 10.1002/jcu.20476 PG 5 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA 341FB UT WOS:000258698500005 PM 18446859 ER PT J AU Deng, A Lee, W Pfau, R Harrington, A DiGiovani, J Prickett, KA Dare, DM Petrali, JP AF Deng, April Lee, Wendy Pfau, Richard Harrington, Allan DiGiovani, John Prickett, Kyle A. Dare, David M. Petrali, John P. TI Primary cutaneous Langerhans cell sarcoma without Birbeck granules: indeterminate cell sarcoma? SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID HISTIOCYTIC SARCOMA; CLINICOPATHOLOGICAL ENTITY; MALIGNANT HISTIOCYTOSIS; SKIN; ADULT; CLASSIFICATION; LYMPHOMA; DISORDER; TUMORS AB An 88-year-old white male presented with a rapidly growing skin nodule on the scalp. Clinically, the nodule did not appear unusual for an ordinary cutaneous neoplasm on sun-exposed skin of an elderly white male. Histopathological examination showed sheet-like epithelioid tumor cell growth with a vaguely nested pattern and frank malignant features, resembling malignant melanoma. However, the tumor cells possessed irregularly convoluted nuclei with nuclear groves, frequent multinucleation and fine vesicular cytoplasm, features highly suggestive of histiocytes. Immunohistochemistry studies showed that the tumor cells were diffusely positive for S-100 protein and CD1a and negative for HMB-45, Melan-A, cytokeratin and CD30. The provisional diagnosis of Langerhans cell sarcoma was thus favored. To confirm this diagnosis, electron microscopic examination was performed. Although classic features of histiocytes were readily identifiable, no Birbeck granules could be found upon a thorough search on repeated sections. These results are indicative of the indeterminate cell nature of the tumor. We propose a diagnosis of primary cutaneous indeterminate cell sarcoma for this unusual histiocytic neoplasm. Current classification of histiocytic neoplasms and differential diagnosis are reviewed. C1 [Deng, April] Univ Maryland, Dept Dermatol, Baltimore, MD 21201 USA. [Lee, Wendy; Pfau, Richard] Anne Arundel Dermatol PA, Pasadena, CA USA. [Harrington, Allan; DiGiovani, John; Prickett, Kyle A.; Dare, David M.] Dermatol & Cosmet Surg Associates PA, Cockeysville, MD USA. [Petrali, John P.] USA, Med Res Inst Chem Def, Dept Comparat Pathol, Aberdeen Proving Ground, MD 21010 USA. RP Deng, A (reprint author), Univ Maryland, Dept Dermatol, 6th Floor,405 W Redwood St, Baltimore, MD 21201 USA. EM adeng@som.umaryland.edu NR 24 TC 9 Z9 10 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD SEP PY 2008 VL 35 IS 9 BP 849 EP 854 DI 10.1111/j.1600-0560.2007.00907.x PG 6 WC Dermatology; Pathology SC Dermatology; Pathology GA 335GW UT WOS:000258279800008 PM 18422973 ER PT J AU Sivananthan, S Anter, Y Dhar, NK AF Sivananthan, S. Anter, Y. Dhar, N. K. TI Foreword SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Editorial Material C1 [Sivananthan, S.; Anter, Y.] Univ Illinois, Microphys Lab, Chicago, IL 60607 USA. [Dhar, N. K.] Army Res Lab, Adelphi, MD 20783 USA. RP Sivananthan, S (reprint author), Univ Illinois, Microphys Lab, 845 W Taylor St,Room 2360 A, Chicago, IL 60607 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1165 EP 1165 DI 10.1007/s11664-008-0505-5 PG 1 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100001 ER PT J AU Benson, JD Martinka, M AF Benson, J. D. Martinka, M. TI Modeling of the structural properties of Hg1-xCdxTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; density functional theory; virtual crystal approximation; ordered alloy approximation; band gap; lattice constant ID ABSORPTION FINE-STRUCTURE; MOLECULAR-BEAM EPITAXY; OPTICAL-ABSORPTION; CADMIUM TELLURIDE; BOND RELAXATION; TERNARY ALLOYS; ELECTRON-GAS; SEMICONDUCTORS; HGCDTE; CD1-YZNYTE AB Structural properties of Hg1-xCdxTe are investigated by using first-principles calculations based on density functional theory. An energetically minimized and geometrically optimized model for Hg1-xCdxTe was formulated. A virtual crystal approximation model for Hg1-xCdxTe produced a poor fit to experimental lattice parameters and Vegard's law. However, the virtual crystal approximation model provides reasonably accurate values for the band gap energy. An ordered alloy approximation model produced a good fit to Hg1-xCdxTe lattice parameters and followed Vegard's law. The ordered alloy approximation also produced a bimodal distribution in Hg-Te and Cd-Te bond lengths in agreement with experimental results. C1 [Benson, J. D.; Martinka, M.] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Benson, JD (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM david.j.benson@us.army.mil NR 41 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 EI 1543-186X J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1166 EP 1170 DI 10.1007/s11664-008-0468-6 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100002 ER PT J AU Chang, Y Becker, CR Grein, CH Zhao, J Fulk, C Casselman, T Kiran, R Wang, XJ Robinson, E An, SY Mallick, S Sivananthan, S Aoki, T Wang, CZ Smith, DJ Velicu, S Zhao, J Crocco, J Chen, Y Brill, G Wijewarnasuriya, PS Dhar, N Sporken, R Nathan, V AF Chang, Yong Becker, C. R. Grein, C. H. Zhao, J. Fulk, C. Casselman, T. Kiran, R. Wang, X. J. Robinson, E. An, S. Y. Mallick, S. Sivananthan, S. Aoki, T. Wang, C. Z. Smith, D. J. Velicu, S. Zhao, J. Crocco, J. Chen, Y. Brill, G. Wijewarnasuriya, P. S. Dhar, N. Sporken, R. Nathan, V. TI Surface morphology and defect formation mechanisms for HgCdTe (211)B grown by molecular beam epitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; molecular beam epitaxy; defect; slip; Schmid factor; Burgers vector; dislocation ID MERCURY CADMIUM TELLURIDE; ATOMIC-FORCE MICROSCOPY; ELECTRON-MICROSCOPY; CROSS-HATCH; HGTE/HGCDTE SUPERLATTICES; STRESS-RELAXATION; CRATER DEFECTS; VOID DEFECTS; EPILAYERS; CDTE AB The surface morphology and crystallinity of HgCdTe films grown by molecular beam epitaxy (MBE) on both CdZnTe and CdTe/Si (211)B substrates were characterized using atomic force microscopy (AFM), as well as scanning (SEM) and transmission (TEM) electron microscopy. Crosshatch patterns and sandy-beach-like morphologies were commonly found on MBE (211) HgCdTe epilayers grown on both CdZnTe and CdTe/Si substrates. The patterns were oriented along the [(2) over bar 13], [(2) over bar 13], and [0 (1) over bar1] directions, which were associated with the intersection between the (211) growth plane and each of the eight equivalent HgCdTe slip planes. This was caused by strain-driven operation of slip in these systems with relative large Schmid factor, and was accompanied by dislocation formation as well as surface strain relief. Surface crater defects were associated with relatively high growth temperature and/or low Hg flux, whereas microtwins were associated with relatively low growth temperature and/or high Hg flux. AFM and electron microscopy were used to reveal the formation mechanisms of these defects. HgCdTe/HgCdTe superlattices with layer composition differences of less than 2% were grown by MBE on CdZnTe substrates in order to clarify the formation mechanisms of void defects. The micrographs directly revealed the spiral nature of growth, hence demonstrating that the formation of void defects could be associated with the Burton, Cabrera, and Frank (BCF) growth mode. Void defects, including microvoids and craters, were caused by screw defect clusters, which could be triggered by Te precipitates, impurities, dust, other contamination or flakes. Needle defects originated from screw defect clusters linearly aligned along the [0 (1) over bar1] directions with opposite Burgers vector directions. They were visible in HgCdTe epilayers grown on interfacial superlattices. Hillocks were generated owing to twin growth of void or needle defects on (111) planes due to low growth temperature and the corresponding insufficient Hg movement on the growth surface. Therefore, in addition to nucleation and growth of HgCdTe in the normal two-dimensional layer growth mode, the BCF growth mode played an important role and should be taken into account during investigation of HgCdTe MBE growth mechanisms. C1 [Chang, Yong; Becker, C. R.; Grein, C. H.; Zhao, J.; Fulk, C.; Casselman, T.; Kiran, R.; Wang, X. J.; Robinson, E.; An, S. Y.; Mallick, S.; Sivananthan, S.; Sporken, R.] Univ Illinois, Dept Phys, Microphys Lab, Chicago, IL 60607 USA. [Aoki, T.; Wang, C. Z.; Smith, D. J.] Arizona State Univ, Ctr Solid State Sci, Tempe, AZ 85287 USA. [Aoki, T.; Wang, C. Z.; Smith, D. J.] Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA. [Velicu, S.; Zhao, J.; Crocco, J.] EPIR Technol Inc, Bolingbrook, IL 60440 USA. [Chen, Y.; Brill, G.; Wijewarnasuriya, P. S.; Dhar, N.] USA, Res Lab, AMSRL SE EI, Adelphi, MD 20783 USA. [Sporken, R.] Univ Namur FUNDP, Dept Phys, B-5000 Namur, Belgium. [Nathan, V.] AF Res Lab, Albuquerque, NM 87117 USA. RP Chang, Y (reprint author), Univ Illinois, Dept Phys, Microphys Lab, Chicago, IL 60607 USA. EM yonchang@uic.edu RI Brill, Gregory/G-4877-2013; Aoki, Toshihiro/I-4852-2015 NR 59 TC 12 Z9 13 U1 2 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1171 EP 1183 DI 10.1007/s11664-008-0477-5 PG 13 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100003 ER PT J AU Carmody, M Pasko, JG Edwall, D Piquette, E Kangas, M Freeman, S Arias, J Jacobs, R Mason, W Stoltz, A Chen, Y Dhar, NK AF Carmody, M. Pasko, J. G. Edwall, D. Piquette, E. Kangas, M. Freeman, S. Arias, J. Jacobs, R. Mason, W. Stoltz, A. Chen, Y. Dhar, N. K. TI Status of LWIR HgCdTe-on-silicon FPA technology SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE MBE; HgCdTe; silicon; FPA; infrared; LWIR ID DISLOCATIONS; PHOTODIODES; DETECTORS AB The use of silicon as an alternative substrate to bulk CdZnTe for epitaxial growth of HgCdTe for infrared detector applications is attractive because of potential cost savings as a result of the large available sizes and the relatively low cost of silicon substrates. However, the potential benefits of silicon as a substrate have been difficult to realize because of the technical challenges of growing low-defect-density HgCdTe on silicon where the lattice mismatch is similar to 19%. This is especially true for long-wavelength infrared (LWIR) HgCdTe detectors where the performance can be limited by the high (similar to 5 x 10(6) supercript cm(-2)) dislocation density typically found in HgCdTe grown on silicon. The current status of LWIR (9 mu m to 11 mu m at 78 K) HgCdTe on silicon focal-plane arrays (FPAs) is reviewed. Recent progress is covered including improvements in noise equivalent differential temperature (NEDT) and array operability. NEDT of < 25 mK and NEDT operability > 99% are highlighted for 640 x 480 pixel, 20-mu m-pitch FPAs. C1 [Carmody, M.; Pasko, J. G.; Edwall, D.; Piquette, E.; Kangas, M.; Freeman, S.; Arias, J.] Teledyne Imaging Sensors, Camarillo, CA 93012 USA. [Jacobs, R.; Mason, W.; Stoltz, A.] USA, RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. [Chen, Y.; Dhar, N. K.] Army Res Lab, Adelphi, MD 20783 USA. RP Carmody, M (reprint author), Teledyne Imaging Sensors, 5212 Verdugo Way, Camarillo, CA 93012 USA. EM mcarmody@teledyne.com NR 7 TC 12 Z9 14 U1 2 U2 9 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1184 EP 1188 DI 10.1007/s11664-008-0434-3 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100004 ER PT J AU Stoltz, AJ Benson, JD Smith, PJ AF Stoltz, A. J. Benson, J. D. Smith, P. J. TI Morphology of inductively coupled plasma processed HgCdTe surfaces SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; dry processing; plasma; surfaces; ICP; II-VI; XPS; RHEED; AFM ID CYCLOTRON-RESONANCE PLASMAS; ASPECT-RATIO; WAVELENGTH; HG1-XCDXTE; CH4/H-2/AR; DETECTORS; ARRAYS; CDZNTE; CDTE AB Inductively coupled plasma (ICP) processing has become the industrial processing standard for HgCdTe and its related II-VI compounds. In this study ICP processes were developed that allow several microns of HgCdTe to be plasma etched while maintaining a low root-mean-square (RMS) roughness, and even improving the surface roughness in the case of HgCdTe-on-Si. These ICP processes are superior to older electron cyclotron resonance (ECR) plasma etches. The resulting ICP plasma processed surfaces are oxygen and carbon free, have a good reflection high-energy electron diffraction (RHEED) pattern, and have only a small amount of mercury depletion, x = 0.22 to 0.47 (where x is the ratio of Cd to Hg), in the first 25 angstrom to 30 angstrom of the HgCdTe. Nanofeatures of the as-grown HgCdTe are retained during the process and are believed to be indicative of the fundamental defect mechanisms in the different HgCdTe etched surfaces. Results from these experiments strongly suggest that ICP plasma processes can be used to delineate pixels, etch vias, clean surfaces, and even produce epi-ready surfaces that would allow HgCdTe to become much more manufacturable, and perhaps allow the replacement of wet processing in HgCdTe. C1 [Stoltz, A. J.; Benson, J. D.; Smith, P. J.] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. RP Stoltz, AJ (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM andrew.stoltz@nvl.army.mil NR 19 TC 7 Z9 8 U1 0 U2 5 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1225 EP 1230 DI 10.1007/s11664-008-0467-7 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100010 ER PT J AU Benson, JD Jacobs, RN Markunas, JK Jaime-Vasquez, M Smith, PJ Almeida, LA Martinka, M Vilela, MF Lee, U AF Benson, J. D. Jacobs, R. N. Markunas, J. K. Jaime-Vasquez, M. Smith, P. J. Almeida, L. A. Martinka, M. Vilela, M. F. Lee, U. TI Structural analysis of CdTe hetero-epitaxy on (211) Si SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; CdTe/Si; molecular-beam epitaxy; atomic force microscopy; X-ray diffraction full-width at half-maximum; reflection high-energy electron diffraction; etch pit density; mosaic structure ID MOLECULAR-BEAM EPITAXY; WAVELENGTH INFRARED HGCDTE; X-RAY-DIFFRACTION; DIODE PERFORMANCE; (211)B HGCDTE; DISLOCATIONS; SURFACE; GROWTH; PHOTODIODES; DETECTORS AB X-ray diffraction full-width at half-maximum (XRD FWHM), reflection high-energy electron diffraction (RHEED), and atomic force microscopy (AFM) indicate a mosaic structure for molecular-beam epitaxy (MBE) (211)B CdTe/Si. AFM measurements indicate long, thin, small-angle-disoriented grains for CdTe/Si epilayers. These disoriented grains are similar to 1 mu m in the [(1) over bar 11] direction and are similar to 40 nm in the [01 (1) over bar] direction. The RHEED pattern in the [(1) over bar 11] direction depicts nearly ideal single-crystal periodicity. The RHEED pattern in the [01 (1) over bar] direction is indicative of small-angle-disoriented crystalline grains. Scanning electron microscopy (SEM), AFM, and XRD measurements all indicate an approximate factor of 10 increase in the Everson etch pit density (EPD) over standard Nomarski microscopy Everson EPD determination. C1 [Benson, J. D.; Jacobs, R. N.; Markunas, J. K.; Jaime-Vasquez, M.; Smith, P. J.; Almeida, L. A.; Martinka, M.] USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. [Vilela, M. F.] Raytheon Visi Syst, Goleta, CA USA. [Lee, U.] USA, Res Lab, Aberdeen, MD USA. RP Benson, JD (reprint author), USA, RDECOM, CERDEC, Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM dbenson@nvl.army.mil NR 28 TC 20 Z9 20 U1 2 U2 8 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1231 EP 1236 DI 10.1007/s11664-008-0469-5 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100011 ER PT J AU Jaime-Vasquez, M Martinka, M Stoltz, AJ Jacobs, RN Benson, JD Almeida, LA Markunas, JK AF Jaime-Vasquez, M. Martinka, M. Stoltz, A. J. Jacobs, R. N. Benson, J. D. Almeida, L. A. Markunas, J. K. TI Plasma-cleaned InSb (112)B for large-area epitaxy of HgCdTe sensors SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE MBE; CdTe/InSb; XPS; RHEED; plasma cleaning ID MOLECULAR-BEAM EPITAXY; SCANNING-TUNNELING-MICROSCOPY; V SEMICONDUCTOR SURFACES; MISORIENTED SI(001); (111)A HGCDTE; CDTE; DISLOCATIONS; GROWTH; FILMS; HETEROSTRUCTURES AB Plasma etching of (112)B InSb to prepare this semiconductor for the heteroepitaxy deposition of CdTe and initial studies of CdTe epilayers grown by molecular beam epitaxy (MBE) on InSb (112)B substrates cleaned with various plasma treatments are presented. X-ray diffraction rocking curve maps of the MBE CdTe epilayers on 3-inch InSb (112)B substrates have full-width at half-maxima (FWHM) values in the range of 20 arcsec to 30 arcsec. An etch pit density analysis of the 3-inch CdTe epilayers reveals a defect density of 1.0 x 10(7) cm(-2) and 7.7 x 10(5) cm(-2) at the center and edge of the wafer, respectively. Evaluation of a standard HgCdTe annealing process suggests that the removal of the InSb substrate is likely to be needed prior to any postgrowth annealing in Hg overpressure. Finally, we present a low-energy helium plasma exposure of wet-etched InSb (112)B substrates that provides a uniform epi-ready surface that is nearly stoichiometric, and free of oxide and residual contaminants. C1 [Jaime-Vasquez, M.; Martinka, M.; Stoltz, A. J.; Jacobs, R. N.; Benson, J. D.; Almeida, L. A.; Markunas, J. K.] USA, Res Dev & Engn Command RDECOM, Commun Elect Res CERDEC, Night Vis & Elect Sensors Directorate NVESD, Ft Belvoir, VA 22060 USA. RP Jaime-Vasquez, M (reprint author), USA, Res Dev & Engn Command RDECOM, Commun Elect Res CERDEC, Night Vis & Elect Sensors Directorate NVESD, 10221 Burbeck Rd, Ft Belvoir, VA 22060 USA. EM marvin.jaime@nvl.army.mil NR 46 TC 7 Z9 7 U1 0 U2 3 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1247 EP 1254 DI 10.1007/s11664-008-0460-1 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100014 ER PT J AU Wijewarnasuriya, PS Emelie, PY D'Souza, A Brill, G Stapelbroek, MG Velicu, S Chen, YP Grein, C Sivananthan, S Dhar, NK AF Wijewarnasuriya, Priyalal S. Emelie, P. Y. D'Souza, Arvind Brill, Gregory Stapelbroek, Maryn G. Velicu, Silviu Chen, Yuanping Grein, Chris Sivananthan, Sivalingam Dhar, Nibir K. TI Nonequilibrium operation of arsenic diffused long-wavelength infrared HgCdTe photodiodes SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE Auger suppression; nonequilibrium; photovoltaic devices; arsenic p-type doping; molecular beam epitaxy; HgCdTe; long wavelength ID MOLECULAR-BEAM EPITAXY; MINORITY-CARRIER LIFETIME; HG1-XCDXTE; RECOMBINATION; DEVICES; TEMPERATURE; DETECTORS AB We demonstrated a device with a unique planar architecture using a novel approach for obtaining low arsenic doping concentrations in long-wavelength (LW) HgCdTe on CdZnTe substrates. HgCdTe materials were grown by molecular beam epitaxy (MBE). We fabricated a p-on-n structure that we term P(+)/pi/N(+) where the symbol "pi" is to indicate a drastically reduced extrinsic p-type carrier concentration (on the order of mid 10(15) cm(-3)); P(+) and N(+) denote a higher doping density, as well as a higher energy gap, than the photosensitive base pi-region. Fabricated devices indicated that Auger suppression is seen in the P(+)/pi/N(+) architecture at temperatures above 130 K and we obtained a saturation current on the order of 3 mA on 250-mu m-diameter devices at 300 K with Auger suppression. Data shows that about a 50% reduction in dark current is achieved at 300 K due to Auger suppression. The onset of Auger suppression voltage is 450 mV at 300 K and 100 mV at 130 K. Results indicate that a reduction of the series resistance could reduce this further. A principal challenge was to obtain low p-type doping levels in the pi-region. This issue was overcome using a novel deep diffusion process, thereby demonstrating successfully low-doped p-type HgCdTe in MBE-grown material. Near-classical spectral responses were obtained at 250 K and at 100 K with cut-off wavelengths of 7.4 mu m and 10.4 mu m, respectively. At 100 K, the measured non-antireflection-coated quantum efficiency was 0.57 at 0.1 V under backside illumination. C1 [Wijewarnasuriya, Priyalal S.; Brill, Gregory; Chen, Yuanping; Dhar, Nibir K.] USA, Res Lab, Adelphi, MD 20783 USA. [Emelie, P. Y.; Velicu, Silviu; Grein, Chris; Sivananthan, Sivalingam] EPIR Technol, Bolingbrook, IL 60440 USA. [D'Souza, Arvind; Stapelbroek, Maryn G.] DRS Sensors & Targeting Syst, Cypress, CA 90630 USA. RP Wijewarnasuriya, PS (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM pwijewarnasuriya@us.army.mil RI Brill, Gregory/G-4877-2013 NR 26 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1283 EP 1290 DI 10.1007/s11664-008-0455-y PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100018 ER PT J AU Emelie, PY Velicu, S Grein, CH Phillips, JD Wijewarnasuriya, PS Dhar, NK AF Emelie, P. Y. Velicu, S. Grein, C. H. Phillips, J. D. Wijewarnasuriya, P. S. Dhar, N. K. TI Modeling of LWIR HgCdTe auger-suppressed infrared photodiodes under nonequilibrium operation SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE HgCdTe; infrared photodiode; Auger suppression; device modeling; high operating temperature ID TEMPERATURE; HG1-XCDXTE; DEPOSITION; (HG,CD)TE; DETECTORS; LIFETIME; GAP AB The general approach and effects of nonequilibrium operation of Auger-suppressed HgCdTe infrared photodiodes are well understood. However, the complex relationships of carrier generation and dependencies on nonuniform carrier profiles in the device prevent the development of simplistic analytical device models with acceptable accuracy. In this work, finite element methods are used to obtain self-consistent steady-state solutions of Poisson's equation and the carrier continuity equations. Experimental current-voltage characteristics between 120 K and 300 K of HgCdTe Auger-suppressed photodiodes with cutoff wavelength of lambda (c) = 10 mu m at 120 K are fitted using our numerical model. Based on this fitting, we study the lifetime in the absorber region, extract the current mechanisms limiting the dark current in these photodiodes, and discuss design and fabrication considerations in order to optimize future HgCdTe Auger-suppressed photodiodes. C1 [Emelie, P. Y.; Velicu, S.; Grein, C. H.] EPIR Technol, Bolingbrook, IL 60440 USA. [Emelie, P. Y.; Phillips, J. D.] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. [Wijewarnasuriya, P. S.; Dhar, N. K.] USA, Res Lab, Adelphi, MD 20783 USA. RP Emelie, PY (reprint author), EPIR Technol, Bolingbrook, IL 60440 USA. EM pyemelie@umich.edu RI Phillips, Jamie/E-9394-2010 NR 27 TC 14 Z9 14 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1362 EP 1368 DI 10.1007/s11664-008-0427-2 PG 7 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100029 ER PT J AU Jacobs, RN Almeida, LA Markunas, J Pellegrino, J Groenert, M Jaime-Vasquez, M Mahadik, N Andrews, C Qadri, SB Lee, T Kim, M AF Jacobs, R. N. Almeida, L. A. Markunas, J. Pellegrino, J. Groenert, M. Jaime-Vasquez, M. Mahadik, N. Andrews, C. Qadri, S. B. Lee, T. Kim, M. TI Relevance of thermal mismatch in large-area composite substrates for HgCdTe heteroepitaxy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE residual film stress; thermal mismatch; HgCdTe; CdTe buffer; mismatched heteroepitaxy; silicon; germanium; gallium arsenide ID MOLECULAR-BEAM EPITAXY; CRITICAL THICKNESS; CDTE; QUALITY; GROWTH; DETECTORS; SURFACE; LAYERS; SI AB It is well known that the large lattice mismatch (> 14%) associated with CdTe/Si, CdTe/Ge, and CdTe/GaAs composite substrates, is a great contributor to large dislocation densities and other defects that limit the performance of HgCdTe-based infrared detectors. Though thermal expansion mismatch is another possible contributor to material defects, little work has been done towards documenting and understanding its effects in these systems. Here, we perform studies to determine the relative contributions of lattice and thermal mismatch to CdTe film characteristics, including dislocation density and residual stress. Unannealed and thermally cycled films are characterized using x-ray diffraction, defect decoration, and Nomarski and transmission electron microscopy. For CdTe/Si, the residual stress is consistently observed to be tensile, while for CdTe/Ge and CdTe/GaAs, a compressive residual film stress is measured. We show based on theoretically predicted stress levels that the experimental measurements imply the dominance of thermal mismatch in the residual stress characteristics. C1 [Jacobs, R. N.; Almeida, L. A.; Markunas, J.; Pellegrino, J.; Groenert, M.; Jaime-Vasquez, M.] USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Mahadik, N.; Andrews, C.; Qadri, S. B.] USN, Res Lab, Washington, DC 20375 USA. [Lee, T.; Kim, M.] Univ Texas Dallas, Dept Elect Engn, Richardson, TX 75083 USA. RP Jacobs, RN (reprint author), USA, RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. EM rjacobs@nvl.army.mil RI Mahadik, Nadeemullah/C-8551-2009; Kim, Moon/A-2297-2010 NR 24 TC 12 Z9 14 U1 0 U2 2 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1480 EP 1487 DI 10.1007/s11664-008-0519-z PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100048 ER PT J AU Velicu, S Grein, CH Zhao, J Chang, Y An, SY Yadav, A Pipe, K Clark, W AF Velicu, S. Grein, C. H. Zhao, J. Chang, Y. An, S. -Y. Yadav, A. Pipe, K. Clark, W. TI Thermoelectric characteristics in MBE-Grown HgCdTe-Based superlattices SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 26th United States Workshop on Physics and Chemistry of II-VI Materials CY OCT 30-NOV 01, 2007 CL Baltimore, MD SP USA CECOM Night Vis & Elect Sensor Directorate, USA Res Lab, USA SMDC, US Navy Elect Opt Ctr, Penn State Appl Res Lab, Off Naval Res, AF Res Lab, Minerals, Met & Mat Soc, Amer Phys Soc DE thermoelectric; HgCdTe; superlattice; ZT; molecular-beam epitaxy; Seebeck coefficient; thermal conductivity ID THERMAL-CONDUCTIVITY; DEVICES; MERIT; REFRIGERATION; FIGURE AB We present a study on the thermoelectric properties of n-type Hg(0.75)Cd(0.25)Te/Hg(0.7)Cd(0.3)Te superlattices (SLs). This material system was chosen because HgCdTe is the primary material used in high-performance infrared imaging applications. HgCdTe-based devices can be directly grown on Hg(1-x) Cd (x) Te/Hg(1-y) Cd(y) Te SL coolers using advanced growth methods such as molecular-beam epitaxy (MBE), making the monolithic integration of infrared sensors and thermoelectric elements possible. Also, the thermoelectric figure of merit ZT for Hg(0.75)Cd(0.25)Te/Hg(0.7)Cd(0.3)Te SLs is predicted to reach values of 2.09, more than two times greater than that achieved in the best thermoelectric devices based on bulk Bi(2)Te(3). This large ZT is due to the unique and superior electrical and thermal properties of the HgCdTe system, which has not yet been experimentally explored in any great depth as a thermoelectric material. We used a Riber 32P MBE system equipped with a Hg valved cell, reflection high-energy electron diffraction, infrared pyrometer and in situ spectroscopic ellipsometry to grow the thermoelectric structures. MBE was chosen as a growth technique since it allows for the lowest growth temperature compared with other methods, which limits interdiffusion at the interfaces, thereby allowing for a precise control over electrical and thermal properties. Thermal devices were fabricated using standard photolithography and etching techniques. Thermal properties were evaluated using a differential technique. A thermal conductivity of 0.82 +/- 0.07 W/m K and a Seebeck coefficient of 811 +/- 150 mu V/K were measured. Using a measured value of 0.017 Omega cm for the resistivity, an upper bound ZT of 1.4 is estimated. C1 [Velicu, S.; Grein, C. H.; Zhao, J.] EPIR Technol Inc, Unit B, Bolingbrook, IL 60440 USA. [Chang, Y.; An, S. -Y.] Univ Illinois, Microphys Lab, Chicago, IL 60607 USA. [Yadav, A.; Pipe, K.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA. [Clark, W.] USA, Res Off, Durham, NC 27703 USA. RP Velicu, S (reprint author), EPIR Technol Inc, Unit B, 590 Terr Dr, Bolingbrook, IL 60440 USA. EM svelicu@epir.com NR 14 TC 3 Z9 3 U1 1 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD SEP PY 2008 VL 37 IS 9 BP 1504 EP 1508 DI 10.1007/s11664-008-0415-6 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 346AZ UT WOS:000259042100051 ER PT J AU Llopis, JL AF Llopis, Jose L. TI Introduction to this UXO Special Issue of JEEG SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Editorial Material C1 USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Llopis, JL (reprint author), USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. EM Jose.L.Llopis@usace.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD SEP PY 2008 VL 13 IS 3 SI SI BP V EP VI DI 10.2113/JEEG13.3.fmv PG 2 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 361BK UT WOS:000260102300001 ER PT J AU Shubitidze, F Karkashadze, D Barrowes, B Shamatava, I O'Neill, K AF Shubitidze, Fridon Karkashadze, David Barrowes, Ben Shamatava, Irma O'Neill, Kevin TI A New Physics-based Approach for Estimating a Buried Object's Location, Orientation and Magnetic Polarization from EMI Data SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article ID UXO DISCRIMINATION; MODEL AB A new physics-based expression is presented for determining a buried object's location, orientation and magnetic polarizibility. The approach assumes the target exhibits a dipolar response and requires only three global Values: a magnetic field vector H. a vector potential A and a scalar magnetic potential, all at it single location in space. Among these Values. only the scattered magnetic field, H. is measurable with current electromagnetic induction sensors. Therefore, in order to estimate the scattered magnetic scalar and vector potentials from data, a numerical technique called the normalized surface magnetic Source (NSMS) method is employed. Originally, in the NSMS model, the scattered magnetic field Outside the object is reproduced mathematically by equivalent magnetic charges distributed on a three-dimensional (3-D) closed surface. Here, a two-dimensional (2-D) implementation of the NSMS that uses elementary magnetic dipoles, instead of magnetic charges distributed on a planar Surface placed under the measurement grid, is utilized. These sources are used to estimate the scattered magnetic field's vector potential A and scalar magnetic potential 11 Without a prion knowledge of the object's location and orientation. The amplitudes of the NSMS are determined by matching the measured magnetic field with the NSMS modeled field. Once the NSMS amplitudes are determined, H, A, and are simulated on or above the measurement grid. The theoretical basis of the new approach, as well as the practical realization of the 2-D NSMS algorithm used to estimate H, A and above the measurement grid from actual data. Is illustrated. Several numerical and experimental tests for actual EMI sensors are presented. C1 [Shubitidze, Fridon; Karkashadze, David; Shamatava, Irma; O'Neill, Kevin] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. [Shubitidze, Fridon; Shamatava, Irma] Sky Res Inc, Hanover, NH 03755 USA. [Barrowes, Ben; O'Neill, Kevin] USA, Ctr Res Dev & Engn, Hanover, NH 03755 USA. RP Shubitidze, F (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM Fridon.Shubitidze@dartmouth.edu FU Strategic Environmental Research and Development Program [MM-1592, MM-1537, MM-1443]; U.S. Army Corps of Engineers; ERDC Environmental Quality and Installations Program FX This work wits supported by the Strategic Environmental Research and Development Program, MM-1592. MM-1537, MM-1443. and U.S. Army Corps of Engineers, ERDC Environmental Quality and Installations Program. NR 25 TC 10 Z9 10 U1 0 U2 2 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD SEP PY 2008 VL 13 IS 3 SI SI BP 115 EP 130 DI 10.2113/JEEG13.3.115 PG 16 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 361BK UT WOS:000260102300002 ER PT J AU Zhang, B O'Neill, K Kong, JA AF Zhang, Beijia O'Neill, Kevin Kong, Jin Au TI Absolute Calibration of EMI Measurements and Application to Soil Magnetic Susceptibility Inference SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article ID BAND ELECTROMAGNETIC INDUCTION; TARGETS; UXO; DISCRIMINATION; PERMEABILITY; RESISTIVITY; SENSORS AB This paper presents a method for determining a conversion factor for electromagnetic induction (EM I) survey measurements so that fields received ill 111 instrument's native units Call be translated into standard ("absolute") EM units. The method is non-invasive, requiring only a rudimentary characterization of the instrument. Such as loop geometry and the basic nature of the Output Such as the magnetic field, differencing of magnetic field, or time derivative of magnetic field. It does not require knowledge of the device's internal electrical engineering features. Such as amplification, filtering. or transfer functions between components. The technique proceeds by comparing data from controlled measurements to model results, and thus allows one to do similar comparisons henceforth. As all example application and reasonableness check. we use a particular frequency domain (FD) instrument to infer soil magnetic susceptibility value in situ directly from Survey data. The same methodology is applied to a new time domain (TD) instrument. This allows validation of the basic scaling methodology via benchmark cases and also illustrates its transferability. Conversion of data from both instrument types into standard units, for Measurements from the same Soil. illuminates the contrasting nature of the soil responses to TD and FD sensors. It also points out the fundamentally different magnitudes of different components of soil magnetic susceptibility in the soil studied relating to instantaneous response and relaxation response. C1 [Zhang, Beijia; Kong, Jin Au] MIT, Cambridge, MA 02139 USA. [O'Neill, Kevin] Dartmouth Coll, Hanover, NH 03755 USA. [O'Neill, Kevin] USA, Ctr Res Dev & Engn, Hanover, NH 03755 USA. RP Zhang, B (reprint author), MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA. EM beijia@mit.edu NR 33 TC 1 Z9 1 U1 1 U2 2 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD SEP PY 2008 VL 13 IS 3 SI SI BP 223 EP 235 DI 10.2113/JEEG13.3.223 PG 13 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 361BK UT WOS:000260102300009 ER PT J AU Wright, D Bennett, HH Ballard, JH Fields, MP DeMoss, TA Butler, DK AF Wright, David Bennett, Hollis H. Ballard, John H. Fields, Morris P. DeMoss, Tere A. Butler, Dwain K. TI Portable Magnetic/Frequency Domain Electromagnetic Induction Sensor System Development SO JOURNAL OF ENVIRONMENTAL AND ENGINEERING GEOPHYSICS LA English DT Article AB All unexploded ordnance (UXO) Survey instrument that simultaneously collects total Field magnetic data and frequency domain electromagnetic (FDEM) I induction data was developed and tested for the detection and characterization of buried UXO. The system is comprised of an FDEM sensor operating at 9.8 kHz and a cesium vapor magnetometer. The system was initially tested in dynamic Survey (detection) and static cued Survey (characterization) modes at the Naval Research Laboratory Blossom Point UXO test facility in Maryland. During these tests, elect romagnetic (EM) induced bias in the magnetic data was mitigated by physically offsetting the magnetometer from the EM transmitter coils. In the dynamic Survey. the aggregate performance exceeded the detection rates for the individual component sensor technologies. The cued analysis tests showed that target features can be determined by using model-based analyses. and the location estimate errors provided by these analyses were consistently better than the dynamic survey result.,. C1 [Wright, David] SAIC Inc, Arlington, VA 22202 USA. [Bennett, Hollis H.; Ballard, John H.; Fields, Morris P.; DeMoss, Tere A.] USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. [Butler, Dwain K.] Al Sci & Technol Corp, USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Wright, D (reprint author), Wright Res & Design LLC, 9500 E Kingford Dr, Cary, NC 27518 USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ENVIRONMENTAL ENGINEERING GEOPHYSICAL SOC PI DENVER PA 1720 SOUTH BELLAIRE, STE 110, DENVER, CO 80222-433 USA SN 1083-1363 J9 J ENVIRON ENG GEOPH JI J. Environ. Eng. Geophys. PD SEP PY 2008 VL 13 IS 3 SI SI BP 237 EP 245 DI 10.2113/JEEG13.3.237 PG 9 WC Geochemistry & Geophysics; Engineering, Geological SC Geochemistry & Geophysics; Engineering GA 361BK UT WOS:000260102300010 ER PT J AU Waisner, S Medina, VF Morrow, AB Nestler, CC AF Waisner, Scott Medina, Victor F. Morrow, Agnes B. Nestler, Catherine C. TI Evaluation of chemical treatments for a mixed contaminant soil SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID POLYCHLORINATED-BIPHENYLS; POLY(ETHYLENE GLYCOL)/KOH; SIMULTANEOUS REMOVAL; ALKALINE-HYDROLYSIS; HEAVY-METALS; CYCLODEXTRIN; KINETICS; 2,4,6-TRINITROTOLUENE; DESTRUCTION; MIXTURES AB Treatability tests were conducted on soil from the reservoir No. 2 burning ground at the former Plum Brook Ordnance Works in Sandusky, Ohio. This soil is contaminated with explosives 2,4,6-trinitrotolune (TNT) and 2,4/2,6-dinitrotoluene (DNT), polychlorinated biphenyls (PCB, Aroclor 1260), as well as lead. Lime treatment (alkaline hydrolysis) and persulfate oxidation were tested individually and in combination to treat explosives and PCBs. Lime treatment removed 98% of TNT, 75% of DNT, and 80% of PCBs. Similar removal levels were found for persulfate treatment as well as lime followed by persulfate. The percentage of contaminant removal was found to be independent of initial contaminant concentrations. Treatments of the most contaminated soil did not meet the preliminary remediation goals for explosives or PCBs but would allow for disposal in a nonhazardous waste landfill. Treatment of soil with lower initial concentrations easily met the residential (most stringent) preliminary remediation goals of 16, 61, and 0.22 mg kg(-1) for TNT, 2,6-DNT, and PCB (Aroclor 1260), respectively. Neither alkaline hydrolysis nor persulfate oxidation transferred more than 0.02% of the lead from the soil into the reaction waters. Lead was successfully stabilized via phosphate addition. C1 [Waisner, Scott] USA, Ctr Res & Dev, Vicksburg, MS 39180 USA. [Medina, Victor F.; Morrow, Agnes B.] USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. [Nestler, Catherine C.] Appl Res Associates Inc, So Div, Vicksburg, MS 39180 USA. RP Waisner, S (reprint author), USA, Ctr Res & Dev, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM scott.a.waisner@erdc.usace.army.mil; victor.f.medina@erdc.usace.army.mil; agnes.b.morrow@erdc.usace.army.mil; cnestler@ara.com OI Waisner, Scott/0000-0003-4360-4712 NR 40 TC 7 Z9 8 U1 2 U2 22 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD SEP PY 2008 VL 134 IS 9 BP 743 EP 749 DI 10.1061/(ASCE)0733-9372(2008)134:9(743) PG 7 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 338EG UT WOS:000258487800005 ER PT J AU Wang, GX Gertner, G Howard, H Anderson, A AF Wang, Guangxing Gertner, George Howard, Heidi Anderson, Alan TI Optimal spatial resolution for collection of ground data and multi-sensor image mapping of a soil erosion cover factor SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE cost-efficiency; mapping; optimal spatial resolution; remote sensing; sampling; soil erosion; spatial variability ID PLOT SIZE; VEGETATION COVER; VARIOGRAMS AB Military training activities disturb ground and vegetation cover of landscapes and increases potential soil erosion. To monitor the dynamics of soil erosion, there is an important need for an optimal sampling design in which determining the optimal spatial resolutions in terms of size of sample plots used for the collection of ground data and the size of pixels for mapping. Given a sample size, an optimal spatial resolution should be cost-efficient in both sampling costs and map accuracy. This study presents a spatial variability-based method for that purpose and compared it with the traditional methods in a study area in which a soil erosion cover factor was sampled and mapped with multiple plot sizes and multi-sensor images. The results showed that the optimal spatial resolutions obtained using the spatial variability-based method were 12 and 20m for years 1999 and 2000, respectively, and were consistent with those using the traditional methods. Moreover, the most appropriate spatial resolutions using the high-resolution images were also consistent with those using ground sample data, which provides a potential to use the high-resolution images were also consistent with those spatial resoultions before sampling. The most appropriate spatial resolutions above were then verified in terms of cost-efficiency which was defined, as the product of sampling cost and map error using ordinary kriging without images and sequential Gaussian co-simulation with images to generate maps. (c) 2007 Elsevier Ltd. All rights reserved. C1 [Wang, Guangxing; Gertner, George] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. [Howard, Heidi; Anderson, Alan] USA Corps Engineers, Construct Engn Res Lab, Champaign, IL USA. RP Gertner, G (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM gertner@uiuc.edu FU US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) FX We are grateful to US Army Corps of Engineers, Construction Engineering Research Laboratory (USA-CERL) for providing support and data sets for this Study. NR 29 TC 8 Z9 8 U1 1 U2 13 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD SEP PY 2008 VL 88 IS 4 BP 1088 EP 1098 DI 10.1016/j.jenvman.2007.05.014 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA 343RO UT WOS:000258871900050 PM 17628322 ER PT J AU Pickard, SW Clarke, JU AF Pickard, Scott W. Clarke, Joan U. TI Benthic Bioaccumulation and Bioavailability of Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans from Surficial Lake Ontario Sediments SO JOURNAL OF GREAT LAKES RESEARCH LA English DT Article DE Dioxin/dibenzofuran-contaminated sediments; bioavailability; bioaccumulation; biota-sediment accutnulationfiactors; Lake Ontario ID POLYCYCLIC AROMATIC-HYDROCARBONS; WATER PARTITION-COEFFICIENTS; LUMBRICULUS-VARIEGATUS; ORGANIC CONTAMINANTS; ACCUMULATION FACTORS; CHIRONOMUS-TENTANS; BLACK CARBON; PARA-DIOXINS; GREAT-LAKES; FISH AB The benthic bioavailability of surface sediment-associated polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) was quantified and assessed in Lake Ontario. Bottom sediments were collected from three areas along the Lake Ontario southern shoreline near Olcott, Rochester, and Oswego, New York. The sediment samples were subjected to 28-day, PCDD/F bioaccumulation experiments using the aquatic oligochaete Lumbriculus variegatus. Empirical data including only detectable PCDDIF tissue residues were used to quantify the benthic bioavailability of 11 PCDDIF congeners through the calculation c of biota-sediment accumulation factors (BSAFs). BSAFs calculated for at least two lake areas were combined as Lake Ontario BSAFs for those specific congeners. Variability of the BSAFs was estimated by propagated error (PE) terms. Mean Lake Ontario BSAFs (+/- PE) ranged from 0.04 +/- 0.02 for octachlorodibenzofuran (OCDF) to 2.42 +/- 1.32 for 1,2,3,6,7,8-hexachlorodibenzofuran (HxCDF). Tetra- chlorodibenzo-p-dioxin (TCDD) and 1,2,3,4,7,8-HxCDF, shown to be among the highest toxic equivalencies (TEQs) in lake sediments, yielded BSAFs of 0.51 +/- 0.18 and 0.22 +/- 0.12, respectively. Statistical comparison of the TCDD BSAFs showed no significant differences among the lake areas. The benthic bioavailability, of TCDD appeared lower than the results of other investigators. While hydrophobicity and degree of chlorination play some role, other factors, such as steric properties, and composition of organic carbon and matter, may have had a greater influence on the benthic bioavailability of PCDDIF congeners. Comparisons of these benthic BSAFs to fish BSAFs suggest that the bioaccumulation of PCDDIF congeners by fish is more related to water solubility and degree of chlorination than to sediment concentration. C1 [Pickard, Scott W.] USA, Corps Engineers, Tech Serv Div, Buffalo, NY 14207 USA. [Clarke, Joan U.] USA, Engineer Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Pickard, SW (reprint author), USA, Corps Engineers, Tech Serv Div, 1776 Niagara St, Buffalo, NY 14207 USA. EM scott.w.pickard@usace.army.mil FU USACE; Operation and Maintenance Programs FX We thank USACE colleagues William Butler, Joseph Rowley, David Swiatek, Scott Schleuter, Michael Asquith, Keith Koralewski, and Trudy Estes for their technical support, and Jay Miller, Dennis Rimer, and Marie Heinz for their field work and logistical assistance. We extend our gratitude to David Persson and Frank Estabrooks of NYSDEC for providing technical support and comments on this manuscript. The authors are very grateful to the reviewers for their contributions to this paper. This work was supported in part by the USACE Dredging Operations Technical Support, and Operation and Maintenance Programs. Publication does not signify that the contents of this paper reflect the views of the U.S. Army Corps of Engineers, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. NR 56 TC 8 Z9 9 U1 2 U2 11 PU INT ASSOC GREAT LAKES RES PI ANN ARBOR PA 2205 COMMONWEALTH BLVD, ANN ARBOR, MI 48105 USA SN 0380-1330 J9 J GREAT LAKES RES JI J. Gt. Lakes Res. PD SEP PY 2008 VL 34 IS 3 BP 418 EP 433 DI 10.3394/0380-1330(2008)34[418:BBABOP]2.0.CO;2 PG 16 WC Environmental Sciences; Limnology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 357ZF UT WOS:000259885100004 ER PT J AU Lukacs, JA Yakimenko, OA AF Lukacs, John A., IV Yakimenko, Oleg A. TI Trajectory-shaping guidance for interception of ballistic missiles during the boost phase SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Article; Proceedings Paper CT AIAA Guidance, Navigation, and Control Conference CY AUG 20-23, 2007 CL Hilton Head Isl, SC C1 [Lukacs, John A., IV] USA, Def Tech Informat Ctr, Ft Belvoir, VA 22060 USA. [Yakimenko, Oleg A.] USN, Postgrad Sch, Dept Mech & Astronaut Engn, Monterey, CA 93943 USA. RP Lukacs, JA (reprint author), USA, Def Tech Informat Ctr, Ft Belvoir, VA 22060 USA. EM john.lukacs.iv@gmail.com; oayakime@nps.edu NR 11 TC 4 Z9 6 U1 0 U2 5 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD SEP-OCT PY 2008 VL 31 IS 5 BP 1524 EP 1531 DI 10.2514/1.32262 PG 8 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA 349FB UT WOS:000259265600038 ER PT J AU Rojas, R Velleux, M Julien, PY Johnson, BE AF Rojas, Rosalia Velleux, Mark Julien, Pierre Y. Johnson, Billy E. TI Grid scale effects on watershed soil erosion models SO JOURNAL OF HYDROLOGIC ENGINEERING LA English DT Article ID DIGITAL ELEVATION MODEL; SEDIMENT TRANSPORT CAPACITY; HYDROLOGICAL MODELS; UPLAND EROSION; OVERLAND-FLOW; RESOLUTION; PARAMETERS; SIZE; RUNOFF; GIS AB The model CASC2D-SED was applied to the Goodwin Creek experimental watershed in Mississippi to define erosion model response to raster-based grid cell sizes. The model was parameterized at a 30 m grid, then calibrated and validated to three representative thunderstorms. The simulated hydrographs replicated the measurements of peak discharge, runoff volume, and time to peak. The model also calculated sediment yields within +/- 50% of the field measurements. Resampling the watershed digital elevation model at scales from 30 m to 330 m reduced the land surface slopes and changed the channel topology. In general, very good modeling results are obtained at grid sizes of 30 m and 90 m, which is comparable to the plot sizes of the universal soil loss equation. At grid sizes coarser than 150 m, the sediment source areas became less appropriately depicted and the calculated sediment delivery ratios became unrealistically high. Grid sizes smaller than 150 m are recommended for proper watershed simulation of upland erosion and sediment yield. C1 [Rojas, Rosalia; Julien, Pierre Y.] Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. [Velleux, Mark] HydroQual Inc, Mahwah, NJ 07430 USA. [Johnson, Billy E.] USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Rojas, R (reprint author), Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA. EM rosalia@sierranieves.com; mvelleux@hydroqual.com; pierre@engr.colostate.edu NR 40 TC 17 Z9 20 U1 2 U2 12 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1084-0699 J9 J HYDROL ENG JI J. Hydrol. Eng. PD SEP PY 2008 VL 13 IS 9 BP 793 EP 802 DI 10.1061/(ASCE)1084-0699(2008)13:9(793) PG 10 WC Engineering, Civil; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA 338DV UT WOS:000258486700005 ER PT J AU Juang, YT Wang, Y Jiang, GS Peng, HB Ergin, S Finnell, M Magilavy, A Kyttaris, VC Tsokos, GC AF Juang, Yuang-Taung Wang, Ying Jiang, Guisen Peng, Hai-Bin Ergin, Sukran Finnell, Michelle Magilavy, Abigail Kyttaris, Vasileios C. Tsokos, George C. TI PP2A dephosphorylates Elf-1 and determines the expression of CD3 zeta and FcR gamma in human systemic lupus erythematosus T cells SO JOURNAL OF IMMUNOLOGY LA English DT Article ID RECEPTOR ZETA-CHAIN; MESSENGER-RNA STABILIZATION; TRANSCRIPTIONAL REGULATION; 3'-UNTRANSLATED REGION; DECREASED EXPRESSION; GENE-EXPRESSION; IL-2 PRODUCTION; C-FOS; PHOSPHORYLATION; PROMOTER AB T cells from patients with systemic lupus erythematosus are characterized by decreased expression of CD3 zeta-chain and increased expression of FcR gamma-chain, which becomes part of the CD3 complex and contributes to aberrant signaling. Elf-1 enhances the expression of CD3, whereas it suppresses the expression of FcR gamma gene and lupus T cells have decreased amounts of DNA-binding 98 kDa form of Elf-1. We show that the aberrantly increased PP2A in lupus T cells dephosphorylates; Elf-1 at Thr-231. Dephosphorylation results in limited expression and binding of the 98 kDa Elf-1 form to the CD3 zeta and FcR gamma promoters. Suppression of the expression of the PP2A leads to increased expression of CD3 zeta and decreased expression of FcR gamma genes and correction of the early signaling response. Therefore, PP2A serves as a central determinant of abnormal T cell function in human lupus and may represent an appropriate treatment target. C1 [Juang, Yuang-Taung; Peng, Hai-Bin; Ergin, Sukran; Finnell, Michelle; Magilavy, Abigail; Kyttaris, Vasileios C.; Tsokos, George C.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, Boston, MA 02115 USA. [Wang, Ying] Walter Reed Army Inst Res, Dept Cellular Injury, Silver Spring, MD 20910 USA. [Jiang, Guisen] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA. RP Juang, YT (reprint author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Rheumatol, 330 Brookline Ave EICLS 957, Boston, MA 02115 USA. EM yjuang@BIDMC.Harvard.edu; gtsokos@bidme.harvard.edu FU National Institutes of Health [R01AI42269, R01AI49954, R01AI068787] FX This work was supported by National Institutes of Health Grants R01AI42269, R01AI49954, and R01AI068787. NR 35 TC 25 Z9 27 U1 3 U2 3 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD SEP 1 PY 2008 VL 181 IS 5 BP 3658 EP 3664 PG 7 WC Immunology SC Immunology GA 352QJ UT WOS:000259511800079 PM 18714041 ER PT J AU Carroll, LM Farr, JV Trainor, TA AF Carroll, Lora M. Farr, John V. Trainor, Timothy A. TI Weighted Scoring Model for Resource Allocation in Postconflict Reconstruction SO JOURNAL OF INFRASTRUCTURE SYSTEMS LA English DT Article DE Reconstruction; Decision making; Resource management; Military engineering AB This paper presents a weighted scoring model as a systematic approach to resource allocation in postconflict reconstruction operations in two distinct environments: adversarial and nonadversarial. The model is intended to aid decision makers in prioritizing, planning, and allocating resources for postconflict reconstruction efforts. Weighted scoring is used to conduct value analysis to determine an appropriate mix of reconstruction projects in a fixed budget portfolio to either maximize overall value or to steer support toward a desired combination of core outcomes. The utility of the model lies in its ability to use the proposed methodology effectively in any postconflict environment to provide quantitative results and a structured decision making approach. While the evaluation measures or metrics may change in each environment, the core outcomes and the central tasks which support those outcomes hold regardless of the type of postconflict environment. These core Outcomes of security, governance, rule of law, economics, and social wellbeing, if achieved, constitute success in postconflict reconstruction operations. C1 [Farr, John V.] Stevens Inst Technol, Dept Syst Engn & Engn Management, Hoboken, NJ 07030 USA. [Carroll, Lora M.] USA, Corps Engineers, Ft Sill Resident Off, Ft Sill, OK 73503 USA. [Trainor, Timothy A.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. RP Farr, JV (reprint author), Stevens Inst Technol, Dept Syst Engn & Engn Management, Hoboken, NJ 07030 USA. EM jfarr@stevens.edu NR 12 TC 0 Z9 0 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 1076-0342 J9 J INFRASTRUCT SYST JI J. Infrastruct. Syst. PD SEP PY 2008 VL 14 IS 3 BP 169 EP 177 DI 10.1061/(ASCE)1076-0342(2008)14:3(169) PG 9 WC Engineering, Civil SC Engineering GA 437LQ UT WOS:000265489400001 ER PT J AU Zhao, YM Fishelevich, R Petrali, JP Zheng, LD Anatolievna, MA Deng, A Eckert, RL Gaspari, AA AF Zhao, Yuming Fishelevich, Rita Petrali, John P. Zheng, Lida Anatolievna, Malinina Alla Deng, April Eckert, Richard L. Gaspari, Anthony A. TI Activation of keratinocyte protein kinase C zeta in psoriasis plaques SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Article ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER RECEPTORS; T-CELLS; FACTOR-ALPHA; TNF-ALPHA; PKC-ZETA; EXPRESSION; PATHOPHYSIOLOGY; TRANSCRIPTION AB PK zeta (protein kinase C-zeta), a member of protein kinase C family, plays an important role in cell proliferation, differentiation, and apoptosis. It acts as a downstream molecule for TNF-alpha (tumor necrosis factor) signal transduction and also regulates the expression of CD1d, an HLA-class I-like molecule. The interaction of CD1d with natural killer T (NKT) cells has been shown to be important in their Th1 cytokine production in psoriasis. In this study, we examined PKC zeta in psoriasis in order to define its role in the pathogenesis of the disease. We found that T-cell receptor (TCR) V alpha 24 + V beta 11 + NKT cells and CD1d molecules within psoriatic skin were increased. Moreover, there was an associated increase in PKC zeta mRNA and protein expression with membrane translocation in psoriasis lesions compared to uninvolved skin. Furthermore, cultured keratinocytes exhibited increased PKC zeta activity and membrane translocation upon stimulation by TNF-alpha, a cytokine known to play an important role in the pathogenesis of psoriasis. These results implied that PKC zeta is an important transduction molecule downstream of TNF-alpha signaling and is associated with increased expression of CD1d that may enhance CD1d-NKT cell interactions in psoriasis lesions. This makes PKC zeta a tempting target for possible pharmacological intervention in modifying the downstream effects of TNF-alpha in psoriasis. C1 [Zhao, Yuming; Fishelevich, Rita; Zheng, Lida; Anatolievna, Malinina Alla; Deng, April; Eckert, Richard L.; Gaspari, Anthony A.] Univ Maryland, Sch Med, Dept Dermatol, Baltimore, MD 21201 USA. [Zhao, Yuming] China Med Univ, Hosp 1, Dept Dermatol, Shenyang, Peoples R China. [Petrali, John P.] USA, Comparat Pathol Branch, Div Comparat Med, Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA. [Eckert, Richard L.] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA. RP Gaspari, AA (reprint author), Univ Maryland, Sch Med, Dept Dermatol, 405 W Redwood St,6th Floor, Baltimore, MD 21201 USA. EM agasp001@umaryland.edu FU NIH [R01-AR46108-05]; Department of Veteran Affairs FX We acknowledge the generous gift of purified NKT cells from Dr D Unutmaz. This work was funded by NIH Grant R01-AR46108-05 and a VA Merit Award from the Department of Veteran Affairs (to AAG). NR 32 TC 22 Z9 22 U1 1 U2 1 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD SEP PY 2008 VL 128 IS 9 BP 2190 EP 2197 DI 10.1038/jid.2008.81 PG 8 WC Dermatology SC Dermatology GA 342ZF UT WOS:000258821400009 PM 18385757 ER PT J AU Nikishin, S Borisov, B Kuryatkov, V Holtz, M Garrett, GA Sarney, WL Sampath, AV Shen, HG Wraback, M Usikov, A Dmitriev, V AF Nikishin, Sergey Borisov, Boris Kuryatkov, Vladimir Holtz, Mark Garrett, Gregory A. Sarney, Wendy L. Sampath, Anand V. Shen, Hongen Wraback, Michael Usikov, Alexander Dmitriev, Vladimir TI Deep UV light emitting diodes grown by gas source molecular beam epitaxy SO JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS LA English DT Article; Proceedings Paper CT 14th International Conference on Semiconducting and Insulating Materials (SIMC-XIV) CY MAY 15-20, 2007 CL Univ Arkansas, Fayetteville, AR HO Univ Arkansas ID SINGLE-QUANTUM-WELL; 280 NM; ALGAN/GAN SUPERLATTICES; EMISSION; OPERATION; PERFORMANCE; EFFICIENCY; ALN/GAN; SI(111); ALLOYS AB We report the structural, electrical, and optical properties of deep UV light emitting diodes (LEDs) grown by gas source molecular beam epitaxy with ammonia on sapphire and AlN/sapphire template substrates. AlN/sapphire substrates were grown by stress controlled hydride vapor phase epitaxy (HVPE). LEDs based on n- and p-type AlN/Al(x)Ga(1-x)N (0.05 <= x <= 0.08) superlattices are demonstrated operating to wavelengths as short as 250 nm. We report a significant enhancement in the cathodoluminescence intensities (by factor of similar to 100) and photoluminescence lifetimes in the Al(x)Ga(1-x)N/Al(y)Ga(1-y)N superlattices consisting of well material grown in the three dimensional mode. We interpret these observations in terms of formation of quantum well/quantum dot active regions. C1 [Nikishin, Sergey; Borisov, Boris; Kuryatkov, Vladimir; Holtz, Mark] Texas Tech Univ, Nano Tech Ctr, Lubbock, TX 79409 USA. [Garrett, Gregory A.; Sarney, Wendy L.; Sampath, Anand V.; Shen, Hongen; Wraback, Michael] AMSRD ARL SE EM, USA, Res Lab, Adelphi, MD 20783 USA. [Usikov, Alexander; Dmitriev, Vladimir] TDI Inc, Silver Spring, MD 20904 USA. RP Nikishin, S (reprint author), Texas Tech Univ, Nano Tech Ctr, Lubbock, TX 79409 USA. EM sergey.a.nikishin@ttu.edu NR 52 TC 8 Z9 8 U1 2 U2 8 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0957-4522 J9 J MATER SCI-MATER EL JI J. Mater. Sci.-Mater. Electron. PD SEP PY 2008 VL 19 IS 8-9 BP 764 EP 769 DI 10.1007/s10854-007-9405-3 PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA 301EK UT WOS:000255879000018 ER PT J AU Apanaskevich, DA Schuster, AL Horak, IG AF Apanaskevich, Dmitry A. Schuster, Anthony L. Horak, Ivan G. TI The genus Hyalomma: VII. Redescription of all parasitic stages of H. (Euhyalomma) dromedarii and H. (E.) schulzei (Acari : Ixodidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Hyalomma (Euhyalomma) dromedarii; Hyalomma (Euhyalomma) schulzei; systematics; geographic distribution; hosts ID BIOLOGY AB The ticks, Hyalomma (Euhyalomma) dromedarii Koch, 1844 and Hyalomma (Euhyalomma) schulzei Olenev, 1931, are considered to be the species most closely associated with camels. H. dromedarii can behave as a three-, two-, or one-host species, with the two-host life cycle seemingly most common. Camels are the main hosts of the adults, which also parasitize other domestic animals. Nymphs and larvae can use the same hosts, especially camels, as the adults, but can also parasitize rodents, leporids, hedgehogs, and birds. H. dromedarii is widely distributed in North Africa, the northern regions of West, Central, and East Africa, Arabia, Asia Minor, the Middle East, and Central and South Asia. H. schulzei is a two-host species. Camels are the principal hosts of the adults, with some records from cattle and goats, whereas the immature stages infest hares, burrowing rodents, and hedgehogs. H. schulzei has a more limited geographic distribution in Asia and Egypt than H. dromedarii, and with the exception Of southeastern Iran, it is a fairly uncommon tick. Among other features that are fairly similar, males of H. dromedarii can be distinguished from those of H. schulzei by a narrow, subtriangular parma, usually very large subanal shields, and a long dorsal prolongation of the spiracular plates. Males of H. schulzei have a broad and rectangular parma, paramedian festoons that protrude posteriorly, smaller subanal shields, and a very short dorsal prolongation of the spiracular plates. The females of H. dromedarii can be distinguished from those of H. schulzei by a narrow V-shaped genital aperture compared with a very wide, deep, U-shaped genital aperture. Here all the parasitic stages of both species are illustrated and redescribed, and characteristics that distinguish the adults from those of other closely related species are supplied. Data on their hosts, geographic distribution and disease relationships are also provided. C1 [Apanaskevich, Dmitry A.] Georgia So Univ, Inst Arthropodol & Parasitol, Statesboro, GA 30460 USA. [Schuster, Anthony L.] USA, Ctr Hlth Promot & Prevent Med S, Ft Mcpherson, GA 30330 USA. [Horak, Ivan G.] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, South Africa. [Horak, Ivan G.] Univ Orange Free State, Dept Zool & Entomol, ZA-9301 Bloemfontein, South Africa. RP Apanaskevich, DA (reprint author), Georgia So Univ, Inst Arthropodol & Parasitol, Statesboro, GA 30460 USA. EM dapanaskevich@georgiasouthern.edu NR 26 TC 17 Z9 18 U1 0 U2 3 PU ENTOMOLOGICAL SOC AMER PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2008 VL 45 IS 5 BP 817 EP 831 DI 10.1603/0022-2585(2008)45[817:TGHVRO]2.0.CO;2 PG 15 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 346VZ UT WOS:000259099000001 PM 18826023 ER PT J AU Foley, DH Rueda, LM Peterson, AT Wilkerson, RC AF Foley, Desmond H. Rueda, Leopoldo M. Peterson, A. Townsend Wilkerson, Richard C. TI Potential distribution of two species in the medically important Anopheles minimus complex (Diptera : Culicidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ecological niche; distribution; Anopheles minimus; Anopheles harrisoni; Anopheles fluviatilis S ID MULTIPLEX PCR ASSAY; MALARIA VECTOR; SOUTHEAST-ASIA; GEOGRAPHIC DISTRIBUTIONS; DISTRIBUTION MODELS; PREDICTIVE MODELS; GENETIC ALGORITHM; NICHE MODELS; IDENTIFICATION; TRANSMISSION AB Anopheles minimus Theobald (=An. minimus A) and possibly Anopheles harrisoni Harbach & Manguin (=An. minimus C) are important malaria vector species in the Minimus Complex in Southeast Asia. The distributions of these species are poorly known, although detailed information could benefit malaria vector incrimination and control. We used published collection records of these species and environmental geospatial data to construct consensus ecological niche models (ENM) of each species' potential geographic distribution. The status of the Indian taxon An. fluviatilis S as a species distinct from An. harrisoni has been debated in the literature, so we tested for differentiation in ecological niche characteristics. The predicted potential distribution of An. minimus is more southerly than that of An. harrisoni: Southeast Asia is predicted to be more suitable for An. minimus, and China and India are predicted more suitable for An. harrisoni, so An. harrisoni seems to dominate under cooler conditions. The distribution of An. minimus is more continuous than that of An. harrisoni: disjunction in the potential distribution of the latter is suggested between India and Southeast Asia. Anopheles fluviatilis S occurrences are predicted within the An. harrisoni ecological potential, so we do not document ecological differentiation that might reject conspecificity. Overall, model predictions offer a synthetic view of the distribution of this species complex across the landscapes of southern and eastern Asia. C1 [Foley, Desmond H.; Rueda, Leopoldo M.; Wilkerson, Richard C.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. [Peterson, A. Townsend] Univ Kansas, Nat Hist Museum, Lawrence, KS 66045 USA. [Peterson, A. Townsend] Univ Kansas, Biodivers Res Ctr, Lawrence, KS 66045 USA. RP Foley, DH (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM foleydes@si.edu RI Valle, Ruben/A-7512-2013; Peterson, A. Townsend/I-5697-2013; OI Peterson, A. Townsend/0000-0003-0243-2379; Foley, Desmond/0000-0001-7525-4601 FU U.S. Department of Defense [G00018_08_WR] FX We thank Monica Papes for advice on analyses. We thank Jean-Paul Chretien for advice and support. Funding for this project was provided by the U.S. Department of Defense Global Emerging Infections Surveillance and Response System, Silver Spring, MD (project G00018_08_WR). NR 63 TC 22 Z9 24 U1 3 U2 7 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-2585 EI 1938-2928 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 2008 VL 45 IS 5 BP 852 EP 860 DI 10.1603/0022-2585(2008)45[852:PDOTSI]2.0.CO;2 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 346VZ UT WOS:000259099000004 PM 18826026 ER PT J AU Franks, R Morefield, S Wen, JG Liao, DX Alvarado, J Strano, M Marsh, C AF Franks, Ryan Morefield, Sean Wen, Jianguo Liao, Dongxiang Alvarado, Jorge Strano, Michael Marsh, Charles TI A Study of Nanomaterial Dispersion in Solution by Wet-Cell Transmission Electron Microscopy SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY LA English DT Article DE Transmission Electron Microscopy (TEM); Dispersion; Nanofluid; Agglomeration; Aluminum oxide; Carbon Nanotubes (CNT); Nanoparticles ID NANOFLUIDS AB Preparation of nanomaterial dispersion or nanofluids requires good characterization techniques, including particle size and morphological measurements. A reliable and straight-forward process to characterize and quantify the degree of dispersion and agglomeration is needed. A wet-cell transmission electron microscope (TEM) technique has been developed to make comparisons between sonicated and hand-shaken solutions of both aluminum oxide nanoparticles and multi-walled carbon nanotubes. In each case, the wet-cell TEM technique reveals images of nanoparticles well dispersed in aqueous solutions due in part to the use of ultrasonic power instead of simply manual shaking and stirring. The technique is currently qualitative and shows great potential for a host of nanotechnology applications. C1 [Franks, Ryan; Morefield, Sean; Marsh, Charles] USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61820 USA. [Wen, Jianguo; Liao, Dongxiang] Univ Illinois, Frederick Seitz Mat Res Lab, Urbana, IL 61801 USA. [Alvarado, Jorge] Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. [Strano, Michael] Univ Illinois, Dept Chem & Biomol Engn, Urbana, IL 61801 USA. RP Marsh, C (reprint author), USA, Construct Engn Res Lab, Corps Engineers, Champaign, IL 61820 USA. RI Zhou, Charlie/N-5376-2015; OI Alvarado, Jorge/0000-0002-4059-6588 FU U.S. Army; U.S. Department of Energy [DE-FG02-07ER46453, DE-FG02-07ER46471] FX The above work was supported by funding through the U.S. Army Environmental Quality/Infrastructure basic research program. In addition, this work was carried out in part in the Frederick Seitz Materials Research Laboratory Central Facilities, University of Illinois, which are partially supported by the U.S. Department of Energy under grants DE-FG02-07ER46453 and DE-FG02-07ER46471. NR 8 TC 17 Z9 17 U1 1 U2 18 PU AMER SCIENTIFIC PUBLISHERS PI STEVENSON RANCH PA 25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USA SN 1533-4880 J9 J NANOSCI NANOTECHNO JI J. Nanosci. Nanotechnol. PD SEP PY 2008 VL 8 IS 9 BP 4404 EP 4407 DI 10.1166/jnn.2008.306 PG 4 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA 370QF UT WOS:000260776900014 PM 19049033 ER PT J AU Voloshinov, VB Balakshy, VI Kulakova, LA Gupta, N AF Voloshinov, V. B. Balakshy, V. I. Kulakova, L. A. Gupta, N. TI Acousto-optic properties of tellurium that are useful in anisotropic diffraction SO JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS LA English DT Article DE acousto-optics; tellurium; anisotropic diffraction; acoustic velocity; photoelastic effect; figure of merit; deflectors; imaging filters ID 10.6 MU-M; FILTER AB The acoustic, optical and acousto-optic (AO) properties of tellurium crystals are examined here with the objective of developing AO devices in this crystal that operate in the 4-8 mu m infrared region. Detailed analysis of anisotropic diffraction of light that is characterized by a change in the optical mode is carried out. The phase velocities of acoustic waves in three basic planes of the material, the directions of elastic polarization, and acoustic walkoff angles are calculated. Magnitudes of the AO figure of merit M(2) in the crystal are evaluated to obtain optimum AO interaction geometries. Our results show that the slow shear elastic waves propagating in XZ and Y Z planes of the crystal may offer the best AO interaction geometry applicable to AO deflectors and imaging filters, and predict a maximum value of M2 in tellurium to be 160 x 10(-12) s(3) kg(-1). Measurement results for optical and AO parameters of tellurium are also included. C1 [Voloshinov, V. B.; Balakshy, V. I.] Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia. [Kulakova, L. A.] AF Ioffe Phys Tech Inst, St Petersburg 194021, Russia. [Gupta, N.] USA, Res Lab, Adelphi, MD 20783 USA. RP Voloshinov, VB (reprint author), Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia. RI Voloshinov, Vitaly/I-6045-2012; Balakshy, Vladimir/J-5941-2012; Gupta, Neelam/B-8702-2013 FU Civilian Research and Development Foundation [RUP1-1663-MO-06] FX The research was supported by grant RUP1-1663-MO-06 of the Civilian Research and Development Foundation. NR 27 TC 18 Z9 21 U1 0 U2 10 PU IOP PUBLISHING LTD PI BRISTOL PA DIRAC HOUSE, TEMPLE BACK, BRISTOL BS1 6BE, ENGLAND SN 1464-4258 J9 J OPT A-PURE APPL OP JI J. Opt. A-Pure Appl. Opt. PD SEP PY 2008 VL 10 IS 9 AR 095002 DI 10.1088/1464-4258/10/9/095002 PG 9 WC Optics SC Optics GA 355HM UT WOS:000259700000004 ER PT J AU Rowsban, HH Hart, K Arnold, JP Thompson, SH Baur, D Keith, K Skidmore, P AF Rowsban, Henry H. Hart, Kristopher Arnold, James P. Thompson, Stevan H. Baur, Dale Keith, Karen Skidmore, Peter TI Treatment of human immunodeficiency virus-associated facial lipodystrophy syndrome with dermafat graft transfer to the nasolabial fold areas: A case report and review of the literature SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Review ID DIABETES-MELLITUS; HYPERLIPIDEMIA; ABNORMALITIES; INHIBITORS C1 [Hart, Kristopher; Arnold, James P.; Thompson, Stevan H.; Baur, Dale; Keith, Karen] Eisenhower Army Med Ctr, Oral & Maxillofacial Surg Residency Program, Ft Gordon, GA USA. RP Rowsban, HH (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd,G1D, Honolulu, HI 96859 USA. EM hrowshan@excite.com NR 16 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD SEP PY 2008 VL 66 IS 9 BP 1932 EP 1938 DI 10.1016/j.joms.2007.05.028 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 343YC UT WOS:000258891300022 PM 18718403 ER PT J AU Sutlive, TG Lopez, HR Schnitker, DE Yawn, SE Halle, RJ Mansfield, LT Boyles, RE Childs, JD AF Sutlive, Thomas G. Lopez, Heather R. Schnitker, Dani E. Yawn, Sarah E. Halle, Robert J. Mansfield, Liem T. Boyles, Robert E. Childs, John D. TI Development of a clinical prediction rule for diagnosing hip osteoarthritis in individuals with unilateral hip pain SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE arthritis; diagnosis; OA; predictive validity ID EXERCISE THERAPY; MANUAL THERAPY; KNEE; RELIABILITY; EPIDEMIOLOGY; DISABILITY; TRIALS; MOTION; RANGE AB STUDY DESIGN: Prospective cohort/predictive validity study. OBJECTIVE: To determine the diagnostic accuracy of common clinical examination items and to construct a preliminary clinical prediction rule for diagnosing hip osteoarthritis (OA) in individuals with unilateral hip pain. BACKGROUND: The current gold standard for the diagnosis of hip OA is a standing anteroposterior (AP) radiograph of the pelvis, Other than for Altman's criteria, little research has been done to determine the accuracy of clinical examination findings for diagnosing hip OA. METHODS AND MEASURES: Seventy-two subjects completed the study. Each subject received a standardized history, physical examination, and standing AP radiograph of the pelvis. Subjects with a Kellgren and Lawrence score of 2 or higher based on the radiographs were considered to have definitive hip OA. Likelihood ratios (LRs) were computed to determine which clinical examination findings were most diagnostic of hip OA. Potential predictor variables were entered into a logistic regression model to determine the most accurate set of clinical examination items for diagnosing hip OA. RESULTS: Twenty-one (29%) of the 72 subjects had radiographic evidence of hip OA. A clinical prediction rule consisting of 5 examination variables was identified. If at least 4 of 5 variables were present, the positive LR was equal to 24.3 (95% confidence interval: 4.4-142.1), increasing the probability of hip OA to 91%. CONCLUSION: The preliminary clinical prediction rule provides the ability to a priori identify patients with hip pain who are likely to have hip OA. A validation study should be done before the rule can be implemented in routine clinical practice. C1 [Sutlive, Thomas G.; Lopez, Heather R.; Schnitker, Dani E.; Yawn, Sarah E.; Halle, Robert J.; Boyles, Robert E.; Childs, John D.] Baylor Univ, USA, Doctoral Program Phys Therapy, Ft Sam Houston, TX 78234 USA. [Mansfield, Liem T.] Brooke Army Med Ctr, Musculoskeletal Sect, Dept Radiol, San Antonio, TX USA. [Mansfield, Liem T.] Brooke Army Med Ctr, Radiol Residency Program, San Antonio, TX USA. RP Sutlive, TG (reprint author), Baylor Univ, USA, Doctoral Program Phys Therapy, 3150 Stanley Rd,Room 1303,ATTN MCCS HMT, Ft Sam Houston, TX 78234 USA. EM thomas.sutlive@amedd.army.mil NR 24 TC 17 Z9 18 U1 0 U2 9 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD SEP PY 2008 VL 38 IS 9 BP 542 EP 550 DI 10.2519/jospt.2008.2753 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 351XH UT WOS:000259458700003 PM 18758047 ER PT J AU Blake, CG Ross, MD AF Blake, Charles G. Ross, Michael D. TI Femoral neck fracture in a military trainee SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article C1 [Ross, Michael D.] Phys Med Training Programs, Sheppard AFB, TX USA. RP Blake, CG (reprint author), 434th Field Artillery Brigade, Ft Sill, OK USA. NR 2 TC 2 Z9 2 U1 0 U2 0 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD SEP PY 2008 VL 38 IS 9 BP 578 EP 578 DI 10.2519/jospt.2008.0409 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 351XH UT WOS:000259458700008 PM 18758049 ER PT J AU Mack, AW Helgeson, MD Tis, JE AF Mack, Andrew W. Helgeson, Melvin D. Tis, John E. TI Contralateral structural femoral autograft use in treatment of an open periarticular knee fracture to perform knee arthrodesis SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE structural autograft; limb salvage; knee arthrodesis; segmental defect ID ARTHROPLASTY; RECONSTRUCTION; ALLOGRAFTS; GRAFTS; NAIL; HIP AB Combat-related blast injuries Often Cause devastating extremity trauma. We report a case of a 21-year-old male service-member who Sustained massive bilateral lower extremity trauma secondary to a blast injury, His orthopaedic injuries included a near traumatic disarticulation of the right knee and a left open type IIIB periarticular knee fracture with traumatic patellectomy, loss of the extensor mechanism, and segmental loss of the distal 11 cm of his femur. Definitive treatment of his injuries included a contralateral structural cortical femoral autograft which was implanted into the left knee segmental defect to facilitate knee fusion with an intramedullary knee fusion nail and a right transfemoral amputation. Radiographic evidence of solid fusion was obtained 8 months postoperatively. Currently, the patient is a community ambulator with the aid of his right lower extremity prosthetic limb and cane. C1 [Mack, Andrew W.; Helgeson, Melvin D.; Tis, John E.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Mack, AW (reprint author), Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM andrew.mack@na.amedd.army.mil NR 18 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD SEP PY 2008 VL 22 IS 8 BP 576 EP 580 DI 10.1097/BOT.0b013e318180f10b PG 5 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 346YD UT WOS:000259104600013 PM 18758291 ER PT J AU Flanigan, EY Aros, S Bueno, MF Conley, M Troendle, JF Cassorla, F Mills, JL AF Flanigan, Elizabeth Y. Aros, Sofia Ferraz Bueno, Maria Conley, Mary Troendle, James F. Cassorla, Fernando Mills, James L. TI Eye malformations in children with heavy alcohol exposure in utero SO JOURNAL OF PEDIATRICS LA English DT Article ID EYEGROUND MALFORMATIONS; OCULAR MANIFESTATIONS; IMAGE-ANALYSIS; OPTIC-NERVE; FETAL; MOTHERS; INVOLVEMENT AB Objective To determine whether children who do not develop fetal alcohol syndrome (FAS) despite heavy alcohol exposure are at risk for eye abnormalities. Study design We screened 9628 pregnant women and identified 101 women who were drinking >= 2 oz of absolute alcohol per day and 101 nondrinking control women. We followed 43 exposed and 55 control offspring between age 4 and 9 years, performing masked standardized ophthalomologic examinations. Results The groups did not differ in their rates of impaired visual acuity, refractory errors, ptosis, epicanthal folds, or short palpebral fissures. Biomicroscopy examination was normal in all exposed subjects; cataracts were detected in 2 control subjects (4%) but in no exposed subjects. Arterial tortuosity was seen in 7 exposed subjects (16%) and in 8 control subjects (15%). Optic nerve hypoplasia was not detected in any subject. Conclusions Previous research has found that children with FAS have a high incidence of serious ophthalmologic defects; our data indicate that the risk is limited to children with FAS and does not extend to children exposed to high levels of alcohol prenatally who do not develop FAS. Eye examinations are unlikely to clarify the diagnosis in children suspected of having alcohol-related damage. C1 [Flanigan, Elizabeth Y.; Conley, Mary; Troendle, James F.; Mills, James L.] NICHD, NIH, DHHS, Div Epidemiol Stat & Prevent Res, Bethesda, MD 20892 USA. [Aros, Sofia] Univ Chile, San Borja Arriaran Clin Hosp, Sch Med, Dept Pediat, Santiago, Chile. [Ferraz Bueno, Maria] Univ Chile, JJ Aguirre Hosp, Santiago, Chile. [Flanigan, Elizabeth Y.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. [Flanigan, Elizabeth Y.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. [Cassorla, Fernando] Univ Chile, Sch Med, Inst Maternal & Child Res, Santiago, Chile. RP Flanigan, EY (reprint author), NICHD, NIH, DHHS, Div Epidemiol Stat & Prevent Res, 6100 Execut Blvd,Room 7B03, Bethesda, MD 20892 USA. EM eflanigan@usuhs.mil FU National Institute of Child Health; Human Development's Intramural Research Program [OHSR-96-04] FX Supported by the National Institute of Child Health and Human Development's Intramural Research Program and protocol/project OHSR-96-04. NR 35 TC 8 Z9 9 U1 0 U2 5 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 J9 J PEDIATR-US JI J. Pediatr. PD SEP PY 2008 VL 153 IS 3 BP 391 EP 395 DI 10.1016/j.jpeds.2008.04.024 PG 5 WC Pediatrics SC Pediatrics GA 348JV UT WOS:000259207700020 PM 18571671 ER PT J AU Nakano, VM Croisant, WJ Mannering, FL Abraham, DM AF Nakano, Victor M. Croisant, William J., Jr. Mannering, Fred L. Abraham, Dulcy M. TI Assessment of emergency room designs for protection against an internal chemical threat SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES LA English DT Article ID POLLUTANT RELEASES; BUILDINGS; TOOL AB Emergency rooms are critical infrastructures that provide acute care and rapid treatment of sudden illnesses and trauma. These life saving services must remain in continuous operation. An internal chemical attack on an emergency room would interrupt these essential services and severely impact the capabilities of the health care professionals and staff. In this paper, a combination of multizone simulation and statistical modeling are used as tools to assess emergency room designs for protection against an internal chemical threat. Design options include: the use of dilution ventilation, additional air handling equipment, gas phase filtration, building segmentation, and a sensor system to improve response time. Protection levels are placed into discrete categories and an ordered probability model (with random effects) is estimated. This model identifies factors, such as the design option, chemical type, elapsed time after chemical release, and the air handling unit's operational and maintenance costs that significantly influence protection levels. Marginal effects are also computed to measure the impact of these factors on the protection-category probabilities. The results of this study can assist owners, designers, and decision makers by providing a quantitative methodology to assess building designs for protection against chemical threats. C1 [Nakano, Victor M.] USA, Edgewood Chem & Biol Ctr, Aberdeen Proving Ground, MD 21010 USA. [Croisant, William J., Jr.] USA, Ctr Res Dev & Engn, Construct Engn Res Lab, Champaign, IL 61822 USA. [Mannering, Fred L.; Abraham, Dulcy M.] Purdue Univ, Sch Civil Engn, W Lafayette, IN 47907 USA. RP Nakano, VM (reprint author), USA, Edgewood Chem & Biol Ctr, 5183 Blackhawk Rd AMSRD ECB RT IM,Bldg E5951,Aber, Aberdeen Proving Ground, MD 21010 USA. EM victor.nakano@us.army.mil; william.j.croisant@usace.army.mil; flm@purdue.edu; dulcy@purdue.edu RI Mannering, Fred/K-8808-2013 OI Mannering, Fred/0000-0002-2803-4582 FU Uniformed Army Scientist and Engineer Ph. D. Program; U. S. Army's Research, Development and Engineering Command FX Funding for doctoral work of the first writer was provided by the Uniformed Army Scientist and Engineer Ph. D. Program and sponsored by the U. S. Army's Research, Development and Engineering Command. The contents of this paper reflect the views of the writers, who are responsible for the facts and the accuracy of the data presented herein. The contents do not necessarily reflect the official views or policies of the U. S. Army. NR 26 TC 0 Z9 0 U1 1 U2 4 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0887-3828 J9 J PERFORM CONSTR FAC JI J. Perform. Constr. Facil. PD SEP-OCT PY 2008 VL 22 IS 5 BP 323 EP 332 DI 10.1061/(ASCE)0887-3828(2008)22:5(323) PG 10 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA 349CY UT WOS:000259257600007 ER PT J AU Irish, JL Resio, DT Ratcliff, JJ AF Irish, Jennifer L. Resio, Donald T. Ratcliff, Jay J. TI The influence of storm size on hurricane surge SO JOURNAL OF PHYSICAL OCEANOGRAPHY LA English DT Article ID WIND; MODEL; SIMULATIONS; PREDICTION; INTENSITY; LOUISIANA; SCALE AB Over the last quarter-century, hurricane surge has been assumed to be primarily a function of maximum storm wind speed, as might be estimated from the Saffir-Simpson hurricane scale. However, Hurricane Katrina demonstrated that wind speed alone cannot reliably describe surge. Herein it is shown that storm size plays an important role in surge generation, particularly for very intense storms making landfall in mildly sloping regions. Prior to Hurricane Katrina, analysis of the historical hurricane record evidenced no clear correlation between surge and storm size, and consequently little attention was given to the role of size in surge generation. In contrast, it is found herein that, for a given intensity, surge varies by as much as 30% over a reasonable range of storm sizes. These findings demonstrate that storm size must be considered when estimating surge, particularly when predicting socioeconomic and flood risk. C1 [Irish, Jennifer L.] Texas A&M Univ, Zachry Dept Civil Engn, College Stn, TX 77843 USA. [Resio, Donald T.] USA, Engn Res & Dev Ctr, Coastal & Hydraul Lab, Vicksburg, MS USA. [Ratcliff, Jay J.] USA Corps Engineers, New Orleans, LA USA. RP Irish, JL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, 3136 TAMU, College Stn, TX 77843 USA. EM jirish@civil.tamu.edu OI Irish, Jennifer/0000-0002-2429-5953 FU U. S. Army Engineer Research and Development Center; Coastal and Hydraulics Laboratory FX The research presented herein was funded by the U. S. Army Engineer Research and Development Center. The authors would like to acknowledge Ms. Linda Lillycrop and Dr. David Levinson for their assistance in gathering information on historical hurricane surge observations and on the Saffir-Simpson scale, respectively. The data and results described herein, unless otherwise noted, were obtained from work funded by or performed by the U. S. Army Engineer Research and Development Center, Coastal and Hydraulics Laboratory. The use of trade names does not constitute an endorsement in the use of these products by the U. S. Government. NR 40 TC 96 Z9 96 U1 8 U2 24 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0022-3670 J9 J PHYS OCEANOGR JI J. Phys. Oceanogr. PD SEP PY 2008 VL 38 IS 9 BP 2003 EP 2013 DI 10.1175/2008JPO3727.1 PG 11 WC Oceanography SC Oceanography GA 354JV UT WOS:000259636800010 ER PT J AU Gould, CH Maybee, GJ Leininger, B Winter, WE AF Gould, Claire H. Maybee, Gabrielle J. Leininger, Brian Winter, William E. TI Primary intussusception in pregnancy - A case report SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE bowel obstruction; intussusception; pregnancy complications ID ADULT INTUSSUSCEPTION; INTESTINAL-OBSTRUCTION; DIAGNOSIS AB BACKGROUND: Intussusception is a rare cause of bowel obstruction in adults, typically associated with malignancy, granuloma formation, a foreign body or an anatomic defect. CASE: A 21-year-old, primiparous woman presented at 33517 weeks' gestation with vague abdominal symptoms consistent with acute viral gastroenteritis. She did not improve with conservative measures. A presumptive diagnosis of severe preeclampsia was made based on elevated blood pressure, abnormal liver function tests and epigastric pain. Labor was induced 34517 weeks' gestation. The patient did not improve after an uncomplicated vaginal delivery. Abdominal radiographs and computed tomography were consistent with intussusception. Surgical findings were consistent with the radiologic findings. The patient underwent a right hemicolectomy with stapled anastomosis. No pathologic or anatomically anomalous lead point was identified intraoperatively or on filial pathology. CONCLUSION: Intussusception is a rare finding in the peripartum period, often presenting with vague abdominal symptoms and mistaken for benign obstetric and nonobstetric diseases. This case is only the second one of adult perinatal intussusception without an anatomic or pathologic lead point. C1 Wilford Hall USAF Med Ctr, Dept Obstet & Gynecol, Lackland AFB, TX USA. Wilford Hall USAF Med Ctr, Dept Gen Surg, Lackland AFB, TX USA. Brooke Army Med Ctr, Dept Obstet & Gynecol, Ft Sam Houston, TX 78234 USA. RP Winter, WE (reprint author), NW Canc Specialists, Div Gynecol Oncol, 265 N Broadway Ave, Portland, OR 97035 USA. EM william.winter@usoncology.com NR 13 TC 1 Z9 1 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD SEP PY 2008 VL 53 IS 9 BP 703 EP 707 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 350WA UT WOS:000259383100013 PM 18839827 ER PT J AU Killgore, WDS Rupp, TL Grugle, NL Reichardt, RM Lipizzi, EL Balkin, TJ AF Killgore, William D. S. Rupp, Tracy L. Grugle, Nancy L. Reichardt, Rebecca M. Lipizzi, Erica L. Balkin, Thomas J. TI Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness SO JOURNAL OF SLEEP RESEARCH LA English DT Article DE caffeine; dextroamphetamine; modafinil; psychomotor vigilance; recovery sleep; side-effects; sleep deprivation ID TOTAL SLEEP-DEPRIVATION; SUSTAINED MENTAL WORK; SLOW-RELEASE CAFFEINE; COGNITIVE PERFORMANCE; D-AMPHETAMINE; RECOVERY SLEEP; DECISION-MAKING; MOOD; ALERTNESS; FATIGUE AB Prolonged sleep loss impairs alertness, vigilance and some higher-order cognitive and affective capacities. Some deficits can be temporarily reversed by stimulant medications including caffeine, dextroamphetamine, and modafinil. To date, only one study has directly compared the effectiveness of these three compounds and specified the doses at which all were equally effective in restoring alertness and vigilance following 64 h of wakefulness. The present study compared the effectiveness of these same three stimulants/doses following a less extreme period of sleep loss (i.e., 44 h). Fifty-three healthy adults received a single dose of modafinil 400 mg (n = 11), dextroamphetamine 20 mg (n = 16), caffeine 600 mg (n = 12), or placebo (n = 14) after 44 h of continuous wakefulness. After 61 h of being awake, participants obtained 12 h of recovery sleep. Psychomotor vigilance was assessed bi-hourly during waking and following recovery sleep. Relative to placebo, all three stimulants were equally effective in restoring psychomotor vigilance test speed and reducing lapses, although the duration of action was shortest for caffeine and longest for dextroamphetamine. At these doses, caffeine was associated with the highest percentage of subjectively reported side-effects while modafinil did not differ significantly from placebo. Subsequent recovery sleep was adversely affected in the dextroamphetamine group, but none of the stimulants had deleterious effects on postrecovery performance. Decisions regarding stimulant selection should be made with consideration of how factors such as duration of action, potential side-effects, and subsequent disruption of recovery sleep may interact with the demands of a particular operational environment. C1 [Killgore, William D. S.] Harvard Univ, McLean Hosp, Sch Med, Neuroimaging Ctr,Cognit Neuroimaging Lab, Belmont, MA 02478 USA. [Grugle, Nancy L.] Cleveland State Univ, Cleveland, OH 44115 USA. [Killgore, William D. S.; Rupp, Tracy L.; Reichardt, Rebecca M.; Lipizzi, Erica L.; Balkin, Thomas J.] Walter Reed Army Inst Res, Dept Behav Biol, Silver Spring, MD USA. RP Killgore, WDS (reprint author), Harvard Univ, McLean Hosp, Sch Med, Neuroimaging Ctr,Cognit Neuroimaging Lab, 115 Mill St, Belmont, MA 02478 USA. EM killgore@mclean.harvard.edu RI Rupp, Tracy/B-3605-2011; OI Killgore, William/0000-0002-5328-0208 NR 51 TC 41 Z9 41 U1 1 U2 9 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0962-1105 J9 J SLEEP RES JI J. Sleep Res. PD SEP PY 2008 VL 17 IS 3 BP 309 EP 321 DI 10.1111/j.1365-2869.2008.00654.x PG 13 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 339VU UT WOS:000258606200010 PM 18522689 ER PT J AU Sahu, J AF Sahu, Jubaraj TI Time-Accurate Numerical Prediction of Free-Flight Aerodynamics of a Finned Projectile SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID ALGORITHM; MOTION AB This article describes a new multidisciplinary computational study undertaken to compute the flight trajectories and simultaneously predict the unsteady free-flight aerodynamics of a finned projectile configuration. Actual flight trajectories are computed using an advanced coupled computational fluid dynamics/rigid body dynamics technique in a body-fixed coordinate system. An advanced time-accurate Navier-Stokes computational technique has been used in computational fluid dynamics to compute the unsteady aerodynamics associated with the free flight of the finned projectile at supersonic speeds. Computed positions and orientations of the projectile have been compared with actual data measured from free-flight tests and are found to be generally in good agreement with the data. Predicted aerodynamics forces and moments also compare well with the forces and moments used in the 6 degree of freedom fits of the results of the same tests. Unsteady numerical results obtained from the coupled method show the flowfield, the aerodynamic coefficients, and the flight paths of the projectile. C1 USA, Res Lab, Aerodynam Branch, Aberdeen Proving Ground, MD 21005 USA. RP Sahu, J (reprint author), USA, Res Lab, Aerodynam Branch, Aberdeen Proving Ground, MD 21005 USA. NR 32 TC 8 Z9 10 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD SEP-OCT PY 2008 VL 45 IS 5 BP 946 EP 954 DI 10.2514/1.34723 PG 9 WC Engineering, Aerospace SC Engineering GA 363NP UT WOS:000260274300009 ER PT J AU Allen, J Hauser, T AF Allen, Jeffrey Hauser, Thomas TI Improved Atomic Oxygen Quantification Within the Earth's Upper Atmosphere Through Numerical Corrections SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID SIMULATION MONTE-CARLO; AERODYNAMIC INFLUENCES; ROCKET; THERMOSPHERE; MIDDLE AB An established method to simulate the aerodynamic effects on in situ sounding rocket measurements is the direct simulation Monte Carlo method. However, very few three-dimensional steady and unsteady simulations with high resolution along a rocket trajectory exist. This study provides three-dimensional steady and unsteady simulations applied to the Second Coupling of Dynamics and Aurora experiment. The results show the validity of a steady-state approach through quantitative comparisons of steady and unsteady simulation results near the rocket's apogee. Steady-state solutions of the flowfield are presented at 2 km intervals along both the upleg and downleg trajectories. The numerical simulations verify the experimental results showing the strong influence of rocket orientation on concentration. Atomic oxygen correction factors, based on the ratio of undisturbed to disturbed flowfield concentrations, are obtained from the numerical results and applied to the experimental sensor data. These correction factors, when applied to uncorrected Second Coupling of Dynamics and Aurora data sets, show a significant improvement over previous research results, particularly along the upleg trajectory, in terms of minimizing the effects of compressible How aerodynamics on the atomic oxygen data. C1 [Allen, Jeffrey] Utah State Univ, USA, Corps Engineers, Engn Res & Dev Ctr, Logan, UT 84322 USA. [Hauser, Thomas] Utah State Univ, Dept Mech & Aerosp Engn, Logan, UT 84322 USA. RP Allen, J (reprint author), Utah State Univ, USA, Corps Engineers, Engn Res & Dev Ctr, Logan, UT 84322 USA. OI Hauser, Thomas/0000-0003-1170-6749 FU National Science Foundation [CTS-0321170]; Utah State University FX The computational resource, the Uinta cluster supercomputer, was provided through the National Science Foundation under grant no. CTS-0321170 with matching funds provided by Utah State University. The authors would like to primarily acknowledge the Space Dynamics Laboratory and the enabling technologies program. Computer time from the Center for High Performance Computing at Utah State University is gratefully acknowledged. NR 23 TC 0 Z9 0 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD SEP-OCT PY 2008 VL 45 IS 5 BP 965 EP 974 DI 10.2514/1.31924 PG 10 WC Engineering, Aerospace SC Engineering GA 363NP UT WOS:000260274300011 ER PT J AU Bernstein, JGW Oxenham, AJ AF Bernstein, Joshua G. W. Oxenham, Andrew J. TI Harmonic segregation through mistuning can improve fundamental frequency discrimination SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID PITCH PERCEPTION; COMPLEX TONES; HEARING-LOSS; LOWER LIMIT; MODEL; IDENTIFICATION; RESOLVABILITY; SELECTIVITY; MODULATION; COMPONENT AB This study investigated the relationship between harmonic frequency resolution and fundamental frequency (f(0)) discrimination. Consistent with earlier studies, f(0) discrimination of a diotic bandpass-filtered harmonic complex deteriorated sharply as the f(0) decreased to the point where only harmonics above the tenth were presented. However, when the odd harmonics were mistuned by 3%, performance improved dramatically, such that performance nearly equaled that found with only even harmonics present. Mistuning also improved performance when alternating harmonics were presented to opposite ears (dichotic condition). In a task involving frequency discrimination of individual harmonics within the complexes, mistuning the odd harmonics yielded no significant improvement in the resolution of individual harmonics. Pitch matches to the mistuned complexes suggested that the even harmonics dominated the pitch for f(0)'s at which a benefit of mistuning was observed. The results suggest that f(0) discrimination performance can benefit from perceptual segregation based on inharmonicity, and that poor performance when only high-numbered harmonics are present is not due to limited peripheral harmonic resolvability. Taken together with earlier results, the findings suggest that f(0) discrimination may depend on auditory filter bandwidths, but that spectral resolution of individual harmonics is neither necessary nor sufficient for accurate f(0) discrimination. (C) 2008 Acoustical Society of America. C1 [Bernstein, Joshua G. W.] Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. [Oxenham, Andrew J.] Univ Minnesota, Dept Psychol, Minneapolis, MN 55455 USA. RP Bernstein, JGW (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM joshua.bernstein@amedd.army.mil OI Oxenham, Andrew/0000-0002-9365-1157 FU NIH [R01 DC 05216] FX This work was supported by NIH Grant No. R01 DC 05216, and was carried out while both authors were at the Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge. MA. The authors thank Christophe Micheyl, Van Summers, three anonymous reviewers, and the associate editor, Richard Freyman, for providing helpful comments on an earlier version of the manuscript. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or Department of Defense. NR 37 TC 21 Z9 24 U1 0 U2 8 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD SEP PY 2008 VL 124 IS 3 BP 1653 EP 1667 DI 10.1121/1.2956484 PN 1 PG 15 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 356PQ UT WOS:000259790500027 PM 19045656 ER PT J AU Foster, CD Hunter, TC Gibbs, PH Leffel, EK AF Foster, Chad D. Hunter, Ty C. Gibbs, Paul H. Leffel, Elizabeth K. TI Whole-body Plethysmography in African Green Monkeys (Chlorocebus aethiops) with and without Jackets SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Article ID EQUINE ENCEPHALITIS-VIRUS; CYNOMOLGUS MACAQUES AB Indwelling central venous catheters are often used to facilitate frequent phlebotomy while minimizing stress and anesthetic effects on animals. However, nonhuman primates with central venous catheters must wear protective jackets. jackets routinely are removed for aerosol exposure to agents and respiratory measurements by whole-body plethysmography (WBP) because of the potentially confounding effects of jackets on these procedures. However, removing the jacket may dislodge the catheter, making it unusable. Using each animal as its own control, we tested 12 African green monkeys to determine whether minute volume, tidal volume, respiratory rate, or accumulated volume measurements by WBP differed depending on whether the animal wore a protective jacket or not. We found no statistical differences in any measured respiratory parameter and concluded that the jackets could be left in place on the animal while undergoing plethysmography without compromising the calculations for determining the inhaled dose of aerosolized agent. In addition, this study revealed no obvious contraindications to leaving the jacket in place in other nonhuman primate species, provided that the jacket fits appropriately and that plethysmography is performed correctly. C1 [Foster, Chad D.] USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. [Hunter, Ty C.; Leffel, Elizabeth K.] USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. RP Foster, CD (reprint author), USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. EM chand.forster1@us.army.mil NR 18 TC 4 Z9 4 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD SEP PY 2008 VL 47 IS 5 BP 52 EP 55 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 361MJ UT WOS:000260131500011 PM 18947172 ER PT J AU Stephens-DeValle, J AF Stephens-DeValle, J. TI Nasal Intubation in the Rabbit: A New Twist on a Difficult Procedure SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE LA English DT Meeting Abstract C1 [Stephens-DeValle, J.] DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA. RI Stephens-Devalle, Julie/B-7890-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1559-6109 J9 J AM ASSOC LAB ANIM JI J. Amer. Assoc. Lab. Anim. Sci. PD SEP PY 2008 VL 47 IS 5 BP 85 EP 86 PG 2 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 361MJ UT WOS:000260131500053 ER PT J AU Edens, JW Blackbourne, LH Beekley, AC Chung, KK Wakefield, MC Cox, ED Eastridge, BJ Holcomb, JB AF Edens, Jason W. Blackbourne, Lorne H. Beekley, Alec C. Chung, Kevin K. Wakefield, Matthew C. Cox, E. Darrin Eastridge, Brian J. Holcomb, John B. TI Long term outcome after combat casualty emergency department thoracotomy (EDT) SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS LA English DT Meeting Abstract CT 94th Annual Clinical Congress of the American-College-of-Surgeons/63rd Annual Sessions of the Owen H Wangensteen Forum on Fundamental Surgical Problems CY OCT 12-16, 2008 CL San Francisco, CA SP Amer Coll Surg C1 [Edens, Jason W.; Blackbourne, Lorne H.; Beekley, Alec C.; Chung, Kevin K.; Wakefield, Matthew C.; Cox, E. Darrin; Eastridge, Brian J.; Holcomb, John B.] USA, Inst Surg Res, Houston, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1072-7515 J9 J AM COLL SURGEONS JI J. Am. Coll. Surg. PD SEP PY 2008 VL 207 IS 3 SU S BP S84 EP S84 DI 10.1016/j.jamcollsurg.2008.06.210 PG 1 WC Surgery SC Surgery GA 349NV UT WOS:000259288500181 ER PT J AU Rueda, LM Rodriguez, JA Bertugio, MC Pecor, JE Li, C Wilkerson, RC AF Rueda, Leopoldo M. Rodriguez, Jose A. Bertugio, Mauricio C. Pecor, James E. Li, Cong Wilkerson, Richard C. TI Anopheles (Nyssorhynchus) pictipennis: A new mosquito record from the Atacama region of northern Chile SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Anopheles pictipennis; Culex quinquqfasciatus; Ochlerotatus albifasciatus; Atacama; northern Chile; new record AB We report the first collection of Anopheles pictipennis from northern Chile, particularly sectors of Totoral, Perales, Puerto Viejo, and Salinas in the Atacama region. Adults were captured using human bait, while larvae and pupae were collected from various habitats including ponds, puddles left by overflowing river water, edges along river banks, wells, irrigation ditches, and permanent and semipermanent ground water. Associated species were Culex (Culex) quinquefasciatus and Ochlerotatus albifasciatus. The internal transcribed spacer 2 of the ribosomal DNA of An. pictipennis was sequenced. C1 [Rueda, Leopoldo M.] Smithsonian Inst, MSC, Walter Reed Biosystemat Unit, Suitland, MD 20746 USA. [Rodriguez, Jose A.; Bertugio, Mauricio C.] Minist Hlth, Hlth Serv, Copiapo 1039, Chile. [Rueda, Leopoldo M.; Pecor, James E.; Li, Cong; Wilkerson, Richard C.] Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Rueda, LM (reprint author), Smithsonian Inst, MSC, Walter Reed Biosystemat Unit, 4210 Silver Hill Rd, Suitland, MD 20746 USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2008 VL 24 IS 3 BP 448 EP 449 DI 10.2987/5692.1 PG 2 WC Entomology SC Entomology GA 351XX UT WOS:000259460400017 PM 18939700 ER PT J AU McLean-Cooper, N Achee, N Foggie, T Grieco, J Williams, J AF McLean-Cooper, Nancy Achee, Nicole Foggie, Tarra Grieco, John Williams, Jack TI Space optimizing methods for laboratory rearing of Aedes aegypti SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article DE Aedes aegypti; larval rearing; insectary; optimization ID WING-LENGTH; MOSQUITOS; CULICIDAE; DIPTERA; SIZE AB Methods used to rear Aedes aegypti larvae were modified to maximize production under limited space requirements. Traditionally, 150 larvae were reared in 25 x 42 x 5-cm pans containing 1 liter of water. It was noticed, however, that the larvae congregated during development and did not utilize the entire rearing environment. Two new rearing methods were investigated to partition larval populations within the rearing space and thus increase rearing efficiency. The 2 methods separated groups of 50 larvae into each of either six 500-ml cylindrical cups or twelve 400-ml rectangular bins, each containing approximately 450 or 400 ml of water, respectively, and occupying approximately the same amount of shelf space as the 25 X 42 cm pans. The cup and bin protocols multiplied rearing potential by 2 and 4, respectively, under the same space constraints. A preliminary experiment was conducted to compare larval development and adult body size (using wing length as a surrogate) of mosquitoes reared in partitioned containers with those reared in the traditional open pan method. Results indicated that the pan and bin partition methods produced adults that were significantly larger than pan-reared adults, yet develop to 4th stage at a significantly slower and less synchronized rate. C1 [McLean-Cooper, Nancy; Williams, Jack] Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. [Achee, Nicole; Foggie, Tarra; Grieco, John] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA. RP McLean-Cooper, N (reprint author), Walter Reed Army Inst Res, Dept Entomol, Div Communicable Dis & Immunol, Silver Spring, MD 20910 USA. NR 8 TC 6 Z9 6 U1 1 U2 4 PU AMER MOSQUITO CONTROL ASSOC PI EATONTOWN PA P O BOX 234, EATONTOWN, NJ 07724-0234 USA SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 2008 VL 24 IS 3 BP 460 EP 462 DI 10.2987/5649.1 PG 3 WC Entomology SC Entomology GA 351XX UT WOS:000259460400021 PM 18939704 ER PT J AU Farwell, M Ross, J Luttrell, R Cohen, D Chin, W Dogaru, T AF Farwell, Mark Ross, Jennifer Luttrell, Richard Cohen, Douglas Chin, Wilbur Dogaru, Traian TI Sense through the wall system development and design considerations SO JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS LA English DT Article DE sense through the wall; radar; situational awareness; wall attenuation; cross range resolution; down range resolution; standoff range; distributed sensors; radar cross section; synthetic aperture; imaging AB This paper presents system design challenges and issues with sensing through walls at different standoff distances and wall types. Efforts for developing sense through the wall (STTW) systems, such as those undertaken by the US Army Technology Objective (ATO) program, aim at providing the soldier with situational awareness information before breaching a building in a military operations in urban terrain (MOUT) environment. STTW capabilities also support law enforcement and search and rescue applications. Since 2002, extensive evaluations of STTW technologies, most notably those performed by the Communications Electronics, Research, Development and Engineering Center (CERDEC) Intelligence and Information Warfare Directorate (I2WD), have been made to determine which technology could be the most viable solution. After conducting comprehensive studies, I2WD initiated several Phase I efforts and Phase II efforts. The purpose behind both efforts was to develop various STTW technology demonstrators under a 5 year ATO. Many lessons learned during the development of Phase I systems were incorporated into the considerations for Phase II developments. This paper discusses design challenges and issues with sensing through walls at different standoff distances and wall types through lessons learned and results from modeling and simulations performed by the Army Research Laboratory. Published by Elsevier Ltd. on behalf of The Franklin Institute. C1 [Farwell, Mark; Ross, Jennifer; Luttrell, Richard; Cohen, Douglas; Chin, Wilbur] USA, CERDEC, Intelligence & Informat Warfare Directorate, Ft Monmouth, NJ 07703 USA. [Dogaru, Traian] USA, Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA. RP Chin, W (reprint author), USA, CERDEC, Intelligence & Informat Warfare Directorate, Ft Monmouth, NJ 07703 USA. EM wilbur.chin@us.army.mil NR 11 TC 33 Z9 34 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0016-0032 J9 J FRANKLIN I JI J. Frankl. Inst.-Eng. Appl. Math. PD SEP PY 2008 VL 345 IS 6 BP 570 EP 591 DI 10.1016/j.jfranklin.2008.01.004 PG 22 WC Automation & Control Systems; Engineering, Multidisciplinary; Engineering, Electrical & Electronic; Mathematics, Interdisciplinary Applications SC Automation & Control Systems; Engineering; Mathematics GA 320AB UT WOS:000257205000003 ER PT J AU Petkie, DT Casto, C De Lucia, FC Murrill, SR Redman, B Espinola, RL Franck, CC Jacobs, EL Griffin, ST Halford, CE Reynolds, J O'Brien, S Tofsted, D AF Petkie, Douglas T. Casto, Corey De Lucia, Frank C. Murrill, Steven R. Redman, Brian Espinola, Richard L. Franck, Charmaine C. Jacobs, Eddie L. Griffin, Steven T. Halford, Carl E. Reynolds, Joe O'Brien, Sean Tofsted, David TI Active and passive imaging in the THz spectral region: phenomenology, dynamic range, modes, and illumination SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID TERAHERTZ; APERTURE AB The useful compromise between resolution and penetration power of the submillimeter or terahertz (THz) spectral region has long made it attractive for a variety of imaging applications. However, many of the demonstrations of imaging in this spectral region have used strategically oriented targets, especially favorable concealment materials, proximate imaging geometries, etc. This paper reports the results of studies aimed at better understanding the phenomenology of targets, the impact of this phenomenology on various active and passive imaging strategies, and most importantly, the development of imaging strategies that do not require the aforementioned special circumstances. Particular attention is paid to the relationship between active and passive images, especially with respect to how they interact with the illumination- and detector-mode structures of various imaging scenarios. It is concluded that the very large dynamic range that can be obtained with active single-mode systems (including focal-plane arrays) can be used in system designs to overcome the deleterious effects that result from the dominance of specular reflections in single-mode active systems as well as to strategically orient targets to obtain recognition. This will aid in the development of a much more robust and generally useful imaging technology in this spectral region. (C) 2008 Optical Society of America. C1 [Casto, Corey; De Lucia, Frank C.] Ohio State Univ, Dept Phys, Columbus, OH 43210 USA. [Petkie, Douglas T.] Wright State Univ, Dept Phys, Dayton, OH 45435 USA. [Murrill, Steven R.] USA, Res Lab, Adelphi, MD 20783 USA. [Redman, Brian] Lockheed Martin Coherent Technol, Louisville, CO 80027 USA. [Espinola, Richard L.; Reynolds, Joe] Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. [Franck, Charmaine C.] CACI Technol Inc, Ft Belvoir, VA 22060 USA. [Jacobs, Eddie L.; Griffin, Steven T.; Halford, Carl E.] Univ Memphis, Dept Elect & Comp Engn, Memphis, TN 38152 USA. [O'Brien, Sean; Tofsted, David] USA, Res Lab, White Sands Missile Range, NM 88002 USA. RP De Lucia, FC (reprint author), Ohio State Univ, Dept Phys, 174 W 18th Ave, Columbus, OH 43210 USA. EM fcd@mps.ohio-state.edu NR 20 TC 29 Z9 31 U1 2 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD SEP PY 2008 VL 25 IS 9 BP 1523 EP 1531 DI 10.1364/JOSAB.25.001523 PG 9 WC Optics SC Optics GA 353FZ UT WOS:000259552800016 ER PT J AU Martini, WZ Cortez, DS Dubick, MA Park, MS Holcomb, JB AF Martini, Wenjun Z. Cortez, Douglas S. Dubick, Michael A. Park, Myung S. Holcomb, John B. TI Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 21st Annual Meeting of the Eastern-Association-for-the-Surgery-of-Trauma CY JAN 15-19, 2008 CL Jacksonville, FL SP Eastern Assoc Surg Trauma DE thrombin; coagulation; thrombelastograph; blood clotting tests; hemorrhage ID ACUTE TRAUMATIC COAGULOPATHY; PLATELET-FUNCTION; MASSIVE TRANSFUSION; COMBAT CASUALTIES; WHOLE-BLOOD; COAGULATION; TEMPERATURE; PATHOPHYSIOLOGY; MANAGEMENT; BYPASS AB Background: Hypothermia and hemorrhagic shock contribute to coagulopathy after trauma. In this study, we investigated the independent and combined effects of hypothermia and hemorrhage with resuscitation on coagulation in swine and evaluated clinically relevant tests of coagulation. Methods: Pigs (n = 24) were randomized into four groups of six animals each: sham control, hypothermia, hemorrhage with resuscitation, and hypothermia, hemorrhage with resuscitation combined. Hypothermia to 32 degrees C was induced with a cold blanket. Hemorrhage was induced by bleeding 35% of total blood volume followed by resuscitation with lactated Ringer's solution. Coagulation was assessed by thrombin generation, prothrombin time (PT), activated partial thromboplastin time (aPTT), activated clotting time (ACT), and thrombelastography (TEG) from blood samples taken at baseline and 4 hour after hypothermia and/or hemorrhage with resuscitation. Data were compared with analysis of variance. Results: Baseline values were similar among groups. There were no changes in any measurements in the control group. Compared with baseline values, hemorrhage with resuscitation increased lactate to 140% +/- 15% (p < 0.05). Hypothermia decreased platelets to 73% +/- 3% (p < 0.05) with no effect on fibrinogen. Hemorrhage with resuscitation reduced platelets to 72% +/- 4% and fibrinogen to 71% +/- 3% (both p < 0.05), with similar decreases in platelets and fibrinogen observed in the combined group. Thrombin generation was decreased to 75% +/- 4% in hypothermia, 67% +/- 6% in hemorrhage with resuscitation, and 75% +/- 10% in the combined group (all p < 0.05). There were no significant changes in PT or aPTT by hemorrhage or hypothermia. ACT was prolonged to 122% +/- 1% in hypothermia, 111% +/- 4% in hemorrhage with resuscitation, and 127% +/- 3 % in the combined group (all p < 0.05). Hypothermia prolonged the initial clotting time (R) and clot formation time (K), and decreased clotting rapidity (alpha) (all p < 0.05). Hemorrhage with resuscitation only decreased clot strength (maximum amplitude [MA], p < 0.05). TEG parameters in the combined group reflected the abnormal R, K, MA, and alpha observed in the other groups. Conclusion: Hypothermia inhibited clotting times and clotting rate, whereas hemorrhage impaired clot strength. Combining hypothermia with hemorrhage impaired all these clotting parameters. PT, aPTT were not sensitive whereas ACT was not specific in detecting these coagulation defects. Only TEG differentiated mechanism related to clotting abnormalities, and thus may allow focused treatment of clotting alterations associated with hypothermia and hemorrhagic shock. C1 [Martini, Wenjun Z.; Cortez, Douglas S.; Dubick, Michael A.; Park, Myung S.; Holcomb, John B.] USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM wenjun.martini@amedd.army.mil NR 38 TC 132 Z9 140 U1 0 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 2008 VL 65 IS 3 BP 535 EP 543 DI 10.1097/TA.0b013e31818379a6 PG 9 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 350BC UT WOS:000259326400008 PM 18784565 ER PT J AU Hackley, JC Demaree, JD Gougousi, T AF Hackley, Justin C. Demaree, J. Derek Gougousi, Theodosia TI Growth and interface of HfO2 films on H-terminated Si from a TDMAH and H2O atomic layer deposition process SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article ID RAY PHOTOELECTRON-SPECTROSCOPY; GATE DIELECTRIC LAYERS; THERMAL-STABILITY; THIN-FILMS; OXIDE; HAFNIUM; SILICON; PRECURSORS; NUCLEATION; SURFACE AB HfO2 thin films have been deposited by an atomic layer deposition (ALD) process using alternating pulses of tetrakis(dimethyl)amino hafnium and H2O precursors at a substrate temperature of 200-325 C. The initial stage of film growth on OH- and H-terminated Si(100) surfaces is investigated using Rutherford backscattering spectrometry (RBS), x-ray photoelectron spectroscopy (XPS), and spectroscopic ellipsometry (SE). The authors observe an initial growth barrier on the Si-H surface for the first approximately four process cycles, where film growth is more efficient on the OH- terminated surface. Both starting surfaces require about 15 cycles to reach a steady growth rate per cycle, with the OH- terminated surface displaying a slightly higher growth rate of 2.7X10(14) Hf/cm(2) compared to 2.4 X 10(14) Hf/cm(2) for Si-H. Combining the RBS and SE data we conclude that the films deposited on the OH- terminated surface are denser than those deposited on the Si-H surface. Angle-resolved XPS measurements reveal the formation of an similar to 8 angstrom interfacial layer after four ALD cycles on the OH-terminated surface for a deposition temperature of 250 degrees C, and transmission electron microscopy verifies that the thickness of the interfacial layer does not change substantially between the 4th and the 25th process cycles. The interfacial layer appears to depend weakly on the deposition temperature from 200 to 325 degrees C, ranging from 6.9 to 8.4 angstrom. (c) 2008 American Vacuum Society. C1 [Hackley, Justin C.; Gougousi, Theodosia] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. [Demaree, J. Derek] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Gougousi, T (reprint author), Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA. EM gougousi@umbc.edu RI Gougousi, Theodosia/C-8156-2014 FU American Chemical Society Petroleum Research Fund; UMBC ADVANCE Institutional Transformation Program [NSF-0244880] FX Acknowledgment is made to the Donors of the American Chemical Society Petroleum Research Fund and the UMBC ADVANCE Institutional Transformation Program (NSF-0244880) for partial support of this research. NR 39 TC 16 Z9 17 U1 0 U2 29 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD SEP PY 2008 VL 26 IS 5 BP 1235 EP 1240 DI 10.1116/1.2965813 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA 349QM UT WOS:000259296000021 ER PT J AU Bean, K Nemelka, K Canchola, P Hacker, S Sturdivant, RX Rico, PJ AF Bean, Krystal Nemelka, Kevin Canchola, Patrick Hacker, Sander Sturdivant, Rodney X. Rico, Pedro J. TI Effects of housing density on Long Evans and Fischer 344 rats SO LAB ANIMAL LA English DT Article ID STRESS-LIKE RESPONSES; SPRAGUE-DAWLEY RATS; FEMALE RATS; COMMON PROCEDURES; LABORATORY RATS; BLOOD-PRESSURE; HEART-RATE; CAGE SIZE; BEHAVIOR; AGGRESSION AB At many breeding facilities, rats are housed at relatively high densities until they are 5 weeks old, at which point they are either shipped for research or rehoused at standard cage densities according to weight. The authors carried out a pilot study in Long Evans and in Fischer 344 rats to investigate whether continuing to house rats at high densities (24 in(2) floor space per rat) past the age of 5 weeks, through puberty and into adulthood would alter behavioral or physiological parameters compared with raising rats at standard densities ( about 72 in(2) floor space per rat). After rats reached puberty, the authors rehoused them with unfamiliar cagemates. The researchers evaluated clinical and behavioral signs of stress, weight, blood glucose concentration, white blood cell count and serum corticosterone concentration. Overall, cage density had little effect on the parameters measured, though gender seemed to affect stress in Long Evans rats. The results suggest that rats of these strains can be raised at the higher densities tested until any age and regrouped with unfamiliar cagemates without compromising rats' welfare or subsequent experimental data. C1 [Bean, Krystal; Nemelka, Kevin; Canchola, Patrick; Rico, Pedro J.] USN, Med Res Ctr, Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. [Hacker, Sander] Univ Texas Hlth Sci Ctr San Antonio, Dept Anim Med, San Antonio, TX 78229 USA. [Sturdivant, Rodney X.] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. RP Bean, K (reprint author), USN, Med Res Ctr, Walter Reed Army Inst Res, Div Vet Med, Silver Spring, MD USA. EM krystal.bean@us.army.mil NR 28 TC 6 Z9 6 U1 1 U2 5 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0093-7355 J9 LAB ANIMAL JI Lab Anim. PD SEP PY 2008 VL 37 IS 9 BP 421 EP 428 DI 10.1038/laban0908-421 PG 8 WC Veterinary Sciences SC Veterinary Sciences GA 340QW UT WOS:000258661100009 PM 18719695 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The American way of war: Guided missiles, misguided men, and a republic at Peril SO LIBRARY JOURNAL LA English DT Book Review C1 [Burgess, Edwin B.] USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 1 PY 2008 VL 133 IS 14 BP 142 EP 142 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 346NJ UT WOS:000259075000182 ER PT J AU Koomullil, R Cheng, G Soni, B Noack, R Prewitt, N AF Koomullil, Roy Cheng, Gary Soni, Bharat Noack, Ralph Prewitt, Nathan TI Moving-body simulations using overset framework with rigid body dynamics SO MATHEMATICS AND COMPUTERS IN SIMULATION LA English DT Article DE overset grids; rigid body dynamics; moving-body problems; library approach ID ATTITUDE REPRESENTATIONS; MESHES; GRIDS; OBJECTS; FLOW AB The simulation of flow past bodies in relative motion is a challenging task due to the presence of complex flow features, moving grids, and rigid body movements under the action of external forces and moments. A generalized grid-based overset framework is presented for the simulation of this class of problems. The equations that govern the fluid flows are cast in an integral form and are solved using a cell-centered finite volume upwind scheme. The rigid body dynamics equations are formulated using quaternion and are solved using fourth-order Runge-Kutta (RK) time integration. The overset framework and the six degree of freedom (6-DOF) rigid body dynamics simulators are developed in a library form for easy incorporation into existing flow solvers. The details of the flow solver, the 6-DOF library, and the overset framework are presented in this paper along with the validation results of the developed system. (C) 2008 IMACS. Published by Elsevier B.V. All rights reserved. C1 [Koomullil, Roy; Cheng, Gary; Soni, Bharat] Univ Alabama, Dept Mech Engn, Birmingham, AL USA. [Noack, Ralph] Penn State Univ, Appl Res Lab, State Coll, PA 16804 USA. [Prewitt, Nathan] Erdc, User Productivity Enhancement & Technol Transfer, DoD High Performance Comp Modernizat Program, Vicksburg, MS USA. RP Koomullil, R (reprint author), BEC 257,1530 3rd Ave S, Birmingham, AL 35294 USA. EM rkoomul@uab.edu NR 32 TC 7 Z9 8 U1 2 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4754 J9 MATH COMPUT SIMULAT JI Math. Comput. Simul. PD SEP PY 2008 VL 78 IS 5-6 BP 618 EP 626 DI 10.1016/j.matcom.2008.04.009 PG 9 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA 334AQ UT WOS:000258195100005 ER PT J AU Ely, MR Martin, DE Cheuvront, SN Montain, SJ AF Ely, Matthew R. Martin, David E. Cheuvront, Samuel N. Montain, Scott J. TI Effect of ambient temperature on marathon pacing is dependent on runner ability SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE environment; endurance exercise; end spurt; distance running; racing ID PERFORMANCE; EXERCISE; STRATEGIES; IMPACT; HEAT AB Warmer weather negatively impacts the finishing time of slower marathon (42.2 km) runners more than faster runners. Flow warmer weather impacts runners' regulation of effort (pacing) leading to the decreased performance is poorly understood. Purpose: To determine the influence of air temperature on pacing of runners with differing abilities throughout the marathon. Methods: Race results were obtained from three Japanese Women's championship marathons that included 5 km times, finishing time, and corresponding weather conditions. A total of 62 race years' outcomes were analyzed using the race winner and 25th, 50th, and 100th place finishers. Results: The fastest marathoners (winners) ran an even pace throughout the race while runners of lesser ability slowed as the race progressed, particularly after 20-25 km. The difference between the first (0-5 km) and last (35-40 km) 5-km split times (pace differential) for the 100th place finishers was the same in cool (C = 5-10 degrees C) as warm (W = 15.1-21 degrees C) conditions (C = 199 +/- 45 s; W = 198 +/- 40 s). The pace differential for the 50th place finisher tended to increase with increasing air temperature (C = 115 +/- 16 s; W = 163 +/- 27 s) but was not significantly different. In contrast, warmer weather resulted in a slowing (P < 0.05) of pace for the 25th place finisher (C = 90 +/- 25 s; W = 191 +/- 20 s) and race winners (C = -22 14 s; W = 24 +/- 13 s). Conclusions: Increasing air temperatures slow pace more in faster runners (winner, 25th) than slower runners (50th, 100th). These results suggest that the negative effect of warmer weather on the finishing times of slower runners is due to slower running velocities from start to finish, rather than a greater deceleration in pace which is exhibited by faster runners. C1 [Ely, Matthew R.; Cheuvront, Samuel N.; Montain, Scott J.] USA, Environm Med Res Inst, Natick, MA 01760 USA. [Martin, David E.] Georgia State Univ, Lab Elite Athlete Performance, Atlanta, GA 30303 USA. RP Ely, MR (reprint author), USA, Environm Med Res Inst, Kansas St,Bdg 42, Natick, MA 01760 USA. EM matthew.ely@us.army.mil NR 23 TC 36 Z9 36 U1 1 U2 15 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD SEP PY 2008 VL 40 IS 9 BP 1675 EP 1680 DI 10.1249/MSS.0b013e318I788da9 PG 6 WC Sport Sciences SC Sport Sciences GA 348MM UT WOS:000259214600017 PM 18685522 ER PT J AU Sharp, MA Knapik, JJ Walker, LA Burrell, L Frykman, PN Darakjy, SS Lester, ME Marin, RE AF Sharp, Marilyn A. Knapik, Joseph J. Walker, Leila A. Burrell, Lolita Frykman, Peter N. Darakjy, Salima S. Lester, Mark E. Marin, Roberto E. TI Physical fitness and body composition after a 9-month deployment to Afghanistan SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE aerobic fitness; military deployment; muscle strength; muscle power ID US-ARMY; WOMEN; VALIDITY AB Purpose: To examine change in physical fitness and body composition after a military deployment to Afghanistan. Methods: One hundred and ten infantry soldiers were measured before and after a 9-month deployment to Afghanistan for Operation Enduring Freedom. Measurements included treadmill peak oxygen uptake (peak VO2), lifting strength, medicine ball put, vertical jump, and body composition estimated via dual-energy x-ray absorptiometry (percent body fat, absolute body fat, fat-free mass. bone mineral content, and bone mineral density). Results: There were significant decreases (P < 0.01) in peak VO2 (-4.5%), medicine ball put (-4.9%), body mass (-1.9%), and fat-free mass (-3.5%). whereas percent body fat increased from 17.71% to 19.6%. Lifting strength and vertical jump performance did not change predeployment to postdeployment. Conclusions: Nine months deployment to Afghanistan negatively affected aerobic capacity, upper body power, and body composition. The predeployment to postdeployment changes were not large and unlikely to present a major health or fitness concern. If deployments continue to be extended and time between deployments decreased, the effects may be magnified and further study warranted. C1 [Sharp, Marilyn A.] USA, Environm Med Res Inst, ATTN MRMC UE EMP, Mil Performance Div, Natick, MA 01760 USA. [Knapik, Joseph J.; Darakjy, Salima S.] USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. [Burrell, Lolita] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. [Marin, Roberto E.] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth Occupat Med, Oklahoma City, OK USA. RP Sharp, MA (reprint author), USA, Environm Med Res Inst, ATTN MRMC UE EMP, Mil Performance Div, Natick, MA 01760 USA. EM marilyn.sharp@us.army.mil NR 21 TC 34 Z9 34 U1 1 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD SEP PY 2008 VL 40 IS 9 BP 1687 EP 1692 DI 10.1249/MSS.0b013e318176b978 PG 6 WC Sport Sciences SC Sport Sciences GA 348MM UT WOS:000259214600019 PM 18685520 ER PT J AU Hassan, HA Kecskes, L Lewandowski, JJ AF Hassan, Hala A. Kecskes, Laszlo Lewandowski, J. J. TI Effects of changes in test temperature and loading conditions on fracture toughness of a Zr-based bulk metallic glass SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID NI-CU-BE; SUPERCOOLED LIQUID REGION; AMORPHOUS-ALLOYS; DEFORMATION-BEHAVIOR; MECHANISM MAPS; VISCOUS-FLOW; ZR41.2TI13.8CU12.5NI10.0BE22.5; COMPRESSION; CORROSION; FATIGUE AB The effects of changes in loading rate and test temperature on the fracture toughness of a Zr-based bulk metallic glass (BMG) were investigated under both displacement-rate-controlled and loading-rate-controlled conditions in three-point bending. The tests were conducted at displacement rates ranging from 0.01 to 10 mm/min, loading rates ranging from 31.5 to 5700 lb/min, and test temperatures from room temperature (298 K) to 623 K. Significant effects of test temperature on the toughness were obtained, while testing under displacement rate control vs loading rate control also produced differences in the toughness and fracture morphology. A preliminary fracture mechanism map is provided to illustrate the effects of changes in temperature and strain rate on the toughness normalized with room-temperature values. C1 [Kecskes, Laszlo] USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. [Lewandowski, J. J.] Case Western Reserve Univ, Dept Mat Sci & Engn, Cleveland, OH 44106 USA. RP Hassan, HA (reprint author), Ain Shams Univ, Fac Engn, Dept Design & Prod Engn, Cairo, Egypt. EM JJL3@case.edu RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 48 TC 18 Z9 18 U1 4 U2 27 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1073-5623 J9 METALL MATER TRANS A JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci. PD SEP PY 2008 VL 39A IS 9 BP 2077 EP 2085 DI 10.1007/s11661-008-9549-7 PG 9 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA 330OG UT WOS:000257952100007 ER PT J AU Bandara, AB DeShazer, D Inzana, TJ Sriranganathan, N Schurig, GG Boyle, SM AF Bandara, Aloka B. DeShazer, David Inzana, Thomas J. Sriranganathan, Nammalwar Schurig, Gerhardt G. Boyle, Stephen M. TI A disruption of ctpA encoding carboxy-terminal protease attenuates Burkholderia mallei and induces partial protection in CD1 mice SO MICROBIAL PATHOGENESIS LA English DT Article DE Burkholderia mallei; Carboxy-terminal protease; Cell morphology; Intracellular survival; Pathogenicity; Protection ID PENICILLIN-BINDING PROTEIN-3; PROCESSING PROTEASE; PHOTOSYSTEM-II; VIRULENCE DETERMINANT; ESCHERICHIA-COLI; GLANDERS; CLONING; GENE; D1; IDENTIFICATION AB Burkholderia mallei is the etiologic agent of glanders in solipeds (horses, mules and donkeys), and incidentally in carnivores and humans. Little is known about the molecular mechanisms of B. mallei pathogenesis. The putative carboxy-terminal processing protease (CtpA) of B. mallei is a member of a novel family of endoproteases involved in the maturation of proteins destined for the cell envelope. All species and isolates of Burkholderia carry a highly conserved copy of ctpA. We studied the involvement of CtpA on growth, cell morphology, persistence, and pathogenicity of B. mallei. A sucrose-resistant strain of B. mallei was constructed by deleting a major portion of the sacB gene of the wild type strain ATCC 23344 by gene replacement, and designated as strain 23344 Delta sacB. A portion of the ctpA gene (encoding CtpA) of strain 23344 Delta sacB was deleted by gene replacement to generate strain 23344 Delta sacB Delta ctpA. In contrast to the wild type ATCC 23344 or the sacB mutant 23344 Delta sacB, the ctpA mutant 23344 Delta sacB Delta ctpA displayed altered cell morphologies with partially or fully disintegrated cell envelopes. Furthermore, relative to the wild type, the ctpA mutant displayed slower growth in vitro and less ability to survive in J774.2 murine macrophages. The expression of mRNA of adtA, the gene downstream of ctpA was similar among the three strains suggesting that disruption of ctpA did not induce any polar effects. As with the wild type or the sacB mutant, the ctpA mutant exhibited a dose-dependent lethality when inoculated intraperitoneally into CD1 mice. The CD1 mice inoculated with a non-lethal dose of the ctpA mutant produced specific serum immunoglobulins IgG1 and IgG2a and were partially protected against challenge with wild type B. mallei ATCC 23344. These findings suggest that CtpA regulates in vitro growth, cell morphology and intracellular survival of B. mallei, and a ctpA mutant protects CD1 mice against glanders. Published by Elsevier Ltd. C1 [Bandara, Aloka B.; Inzana, Thomas J.; Sriranganathan, Nammalwar; Schurig, Gerhardt G.; Boyle, Stephen M.] Virginia Polytech Inst & State Univ, Ctr Mol Med & Infect Dis, Blacksburg, VA 24061 USA. [DeShazer, David] USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Bandara, AB (reprint author), Virginia Polytech Inst & State Univ, Ctr Mol Med & Infect Dis, 1410 Prices Fork Rd, Blacksburg, VA 24061 USA. EM abandara@vt.edu FU Harvey Peters Foundation at Via College of Osteopathic Medicine; Virginia-Maryland Regional College of Veterinary Medicine FX We thank Kathy Lowe for assistance in electron microscopy, Lynn Heffron and Dustin Lucas for expert handling of the mice, and Nancy Tenpenny, Anna Champion, and Kay Carlson for technical assistance. AB was supported by Harvey Peters Foundation at Via College of Osteopathic Medicine and the Virginia-Maryland Regional College of Veterinary Medicine. NR 40 TC 12 Z9 12 U1 0 U2 5 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD SEP PY 2008 VL 45 IS 3 BP 207 EP 216 DI 10.1016/j.micpath.2008.05.005 PG 10 WC Immunology; Microbiology SC Immunology; Microbiology GA 396KW UT WOS:000262591600007 PM 18614331 ER PT J AU Welton, MD AF Welton, Mark D. TI Islam and the Secular State: Negotiating the Future of Shari'a SO MIDDLE EAST JOURNAL LA English DT Book Review C1 [Welton, Mark D.] United State Mil Acad, West Point, NY USA. RP Welton, MD (reprint author), United State Mil Acad, West Point, NY USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MIDDLE EAST INST PI WASHINGTON PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD FAL PY 2008 VL 62 IS 4 BP 727 EP 728 PG 2 WC Area Studies SC Area Studies GA 369SO UT WOS:000260714400024 ER PT J AU Jankunis, MTL AF Jankunis, Major Tonya L. TI MILITARY STRATEGISTS ARE FROM MARS, RULE OF LAW THEORISTS ARE FROM VENUS: WHY IMPOSITION OF THE RULE OF LAW REQUIRES A GOLDWATER-NICHOLS MODELED INTERAGENCY REFORM SO MILITARY LAW REVIEW LA English DT Article C1 [Jankunis, Major Tonya L.] USA, Charlottesville, VA USA. RP Jankunis, MTL (reprint author), USA, TJAGLCS, Adm & Civil Law Dept, Charlottesville, VA USA. NR 96 TC 2 Z9 2 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 2008 VL 197 BP 16 EP 102 PG 87 WC Law SC Government & Law GA 359WA UT WOS:000260017700002 ER PT J AU Ricciardi, R Deuster, PA Talbot, LA AF Ricciardi, Richard Deuster, Patricia A. Talbot, Laura A. TI Metabolic demands of body armor on physical performance in simulated conditions SO MILITARY MEDICINE LA English DT Article ID LOAD-CARRIAGE; ENERGY-COST; ANAEROBIC THRESHOLD; AEROBIC FITNESS; MEDICAL ASPECTS; HEART-RATE; EXERCISE; BACKPACK; WALKING; PREDICTION AB The purpose of this study was to examine physical work performance, energy cost, and physiological fatigue in military personnel during simulated operational conditions. Using a within-subject, repeated- measures design, 34 military personnel volunteered to undergo two experimental conditions: with body armor (BA+) and without BA (BA-). Subjects walked on a treadmill for 30 minutes and completed a physical performance battery during each of two sessions, which were separated by >= 5 days. Subjects with BA+ as compared with BA- had significantly greater increases in: oxygen uptake (VO2) at slow (16.8 +/- 1.5 vs. 18.8 +/- 1.7 mL . kg(-1) . min(-1)) and moderate paces (34.8 +/- 3.9 vs. 40.8 +/- 5.0 mL . kg(-1) . min(-1)); blood lactate at a moderate pace (4.0 +/- 2.4 vs. 6.7 +/- 2.6 mmol/L), heart rate at slow (107 +/- 14 vs. 118 +/- 16 beats per minute) and moderate paces (164 +/- 16 vs. 180 +/- 13 beats per minute); and ratings of perceived physical exertion at slow (8.4 +/- 1.5 vs. 10.4 +/- 1.8) and moderate paces (14.3 +/- 2.3 vs. 16.7 +/- 2.1). Physical tasks were significantly affected by BA: under BA+, men performed 61% fewer pull-ups and women's hang time was reduced by 63%; stair stepping was reduced by 16% for both men and women. BA significantly impacted the physical work capacity of militarily relevant tasks. Specifically, wearing BA significantly increased VO2 when walking at both slow and moderate paces. The potential for physical exhaustion is high and performance of physical tasks is markedly impaired when wearing BA. C1 [Ricciardi, Richard] Walter Reed Army Med Ctr, Washington, DC 20307 USA. [Deuster, Patricia A.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, Bethesda, MD 20814 USA. [Talbot, Laura A.] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Ricciardi, R (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM richard.ricciardi@us.army.mil RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 FU TriService Nursing Research Program FX This study was funded by the TriService Nursing Research Program. NR 35 TC 30 Z9 31 U1 1 U2 8 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2008 VL 173 IS 9 BP 817 EP 824 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 352YW UT WOS:000259534300001 PM 18816920 ER PT J AU Vincent, AS Bleiberg, J Yan, S Ivins, B Reeves, DL Schwab, K Gilliland, K Schlegel, R Warden, D AF Vincent, Andrea S. Bleiberg, Joseph Yan, Sam Ivins, Brian Reeves, Dennis L. Schwab, Karen Gilliland, Kirby Schlegel, Robert Warden, Deborah TI Reference data from the Automated Neuropsychological Assessment Metrics for use in traumatic brain injury in an active duty military sample SO MILITARY MEDICINE LA English DT Article ID PERFORMANCE; TESTS AB The current study examined the performance of active duty soldiers on the Automated Neuropsychological Assessment Metrics (ANAM) traumatic brain injury test battery, to expand the reference data for use in military settings. The effects of age and gender on cognitive performance also were explored. The ANAM traumatic brain injury battery, consisting of six performance tests and two subjective scales, was administered to a sample of healthy active duty soldiers (N = 5,247) as part of a concussion surveillance program. Performance means and SDs, stratified according to age and gender, are reported as reference data. In addition, the impact of age and gender on performance measures was analyzed. Because ANAM is rapidly being adopted for use in many military medical and research applications, the establishment of these reference values is invaluable, particularly for assisting with rapid accurate evaluation and treatment in clinical settings. C1 [Vincent, Andrea S.; Gilliland, Kirby; Schlegel, Robert] Univ Oklahoma, Ctr Study Human Operator Performance, Norman, OK 73072 USA. [Bleiberg, Joseph; Yan, Sam] Natl Rehabil Hosp, Ctr Cognit Neurosci, Washington, DC 20010 USA. [Ivins, Brian; Schwab, Karen; Warden, Deborah] Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. [Reeves, Dennis L.] Clinvest, Springfield, MO 65807 USA. RP Vincent, AS (reprint author), Univ Oklahoma, Ctr Study Human Operator Performance, Norman, OK 73072 USA. FU DVBIC [DAMD17-00-1-0056] FX This study was funded primarily by the DVBIC, with additional support from Cooperative Agreement DAMD17-00-1-0056 between the U.S. Army Medical Research and Materiel Command and the National Rehabilitation Hospital. NR 22 TC 20 Z9 20 U1 3 U2 6 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2008 VL 173 IS 9 BP 836 EP 852 PG 17 WC Medicine, General & Internal SC General & Internal Medicine GA 352YW UT WOS:000259534300004 PM 18816922 ER PT J AU Robinson, R Davis, JD Krueger, M Gore, K Freed, MC Kuesters, P Dube, S Engel, CC AF Robinson, Ronnie Davis, Jamie D. Krueger, Mary Gore, Kristie Freed, Michael C. Kuesters, Phoebe Dube, Shanta Engel, Charles C. TI Acceptability of adverse childhood experiences questions for health surveillance in US armed forces SO MILITARY MEDICINE LA English DT Article ID HOUSEHOLD DYSFUNCTION; SEXUAL-ABUSE; FEMALE SOLDIERS; NAVY RECRUITS; RISK; ADULT; ATTRITION; TRAUMA; IMPACT; MALTREATMENT AB Background: Research has documented a consistent and strong association between adverse childhood experiences (ACE) and negative health outcomes in adulthood. The Department of Defense is expanding health surveillance of military members and considering the inclusion of ACE questions. Objective: To explore the perceptions and attitudes of service members and spouses regarding the use of ACE questions in routine health surveillance. Method: Forty-one active duty service members and spouses were interviewed at two Army troop medical centers. Semistructured qualitative interviews were used to examine their views regarding the use of ACE questions in military health surveillance. Results: Participants believe there is value in health surveillance, however, they are cautious about providing ACE or other information that may be perceived negatively, without confidentiality reassurances. Conclusion: Successful employment of ACE questions in active duty military health surveillance will depend on the ability of military health officials to ensure confidentiality and to communicate the relevance of ACE to health status. C1 [Robinson, Ronnie; Davis, Jamie D.; Gore, Kristie; Freed, Michael C.; Kuesters, Phoebe; Engel, Charles C.] Walter Reed Army Med Ctr, DHCC, Washington, DC 20307 USA. [Krueger, Mary] Womack Army Med Ctr, Dept Family Practice, Ft Bragg, NC 28310 USA. [Gore, Kristie; Freed, Michael C.; Engel, Charles C.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. [Dube, Shanta] Ctr Dis Control & Prevent, Div Adult & Community Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30341 USA. RP Robinson, R (reprint author), Walter Reed Army Med Ctr, DHCC, 6900 Georgia Ave NW,Bldg 2,Room 3E01, Washington, DC 20307 USA. NR 34 TC 4 Z9 4 U1 2 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2008 VL 173 IS 9 BP 853 EP 859 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 352YW UT WOS:000259534300005 PM 18816923 ER PT J AU Ong, AL Joseph, AR AF Ong, Adeline L. Joseph, Antony R. TI Referrals for alcohol use problems in an overseas military environment: Description of the client population and reasons for referral SO MILITARY MEDICINE LA English DT Article ID DRINKING AB Being stationed in an overseas installation has been associated with increased risk for alcohol use problems. Okinawa is a unique overseas environment that often challenges service members with separation from family and friends, limited resources and recreational activities, a high rate of deployment, and restrictive local laws. Single, young, male services members in the junior ranks are at increased risk for poor coping. particularly relying on alcohol use. Maladaptive alcohol use places them at increased risk for engaging in illegal behavior and other negative consequences that subsequently lead them to be referred for an evaluation for alcohol use problems. Alcohol use problems negatively affect health, safety, morale, and mission readiness. Findings from this study strongly suggest that prevention and wellness programs should target young service members in the junior ranks for training on responsible alcohol use, alcohol use problems, and basic coping for improved impact on health and mission readiness. C1 [Ong, Adeline L.] Tripler Army Med Ctr, Dept Psychol, Honolulu, HI 96859 USA. [Joseph, Antony R.] Naval Branch Hlth Clin, Jacksonville, FL 32212 USA. RP Ong, AL (reprint author), Tripler Army Med Ctr, Dept Psychol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. RI Dopko, Rae/J-7437-2015 FU Clinical Investigation Department, Naval Medical Center, San Diego [S-06-140] FX We express our gratitude to the staff members assigned to the Joint Substance Abuse Program, Okinawa, especially Karrin Cotton. Mike Delepine, and Mapuana Cunningham. for their significant contributions in opening a research dialogue about the client population and in treating and caring for U.S. military service members and family members. This work was approved by the Clinical Investigation Department, Naval Medical Center, San Diego Project S-06-140. NR 13 TC 8 Z9 8 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2008 VL 173 IS 9 BP 871 EP 877 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 352YW UT WOS:000259534300008 PM 18816926 ER PT J AU Maranich, AM Rajnik, M AF Maranich, Ashley M. Rajnik, Michael TI Successful treatment of vancomycin-resistant enterococcal ventriculitis in a pediatric patient with linezolid SO MILITARY MEDICINE LA English DT Article ID FAECIUM MENINGITIS AB Although vancomycin-resistant Enterococcus infection of the central nervous system is not common, this organism is becoming an increasing problem in nosocomial infections. We report a 17-month-old male infant with an externalized ventricular peritoneal shunt secondary to infection who subsequently developed a vancomycin-resistant Enterococcus faecium ventriculitis. This infection was successfully treated with a 28-day Course of linezolid while monitoring linezolid drug levels in both the cerebral spinal fluid and serum. This case supports the use of linezolid in treating such resistant infections. However, our drug level results suggest that further investigation is needed to determine the optimal dosing of linezolid in treatment of central nervous system infection in pediatric patients. C1 [Maranich, Ashley M.; Rajnik, Michael] Uniformed Serv Univ Hlth Sci, Dept Pediat, F Edward Herbert Sch Med, Bethesda, MD 20814 USA. [Maranich, Ashley M.] Walter Reed Army Med Ctr, Dept Pediat, Washington, DC 20307 USA. RP Maranich, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Pediat, F Edward Herbert Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA. NR 9 TC 9 Z9 9 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 2008 VL 173 IS 9 BP 927 EP 929 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 352YW UT WOS:000259534300018 PM 18816936 ER PT J AU Lemoine, FJ Degtyareva, NP Kokoska, RJ Petes, TD AF Lemoine, Francene J. Degtyareva, Natasha P. Kokoska, Robert J. Petes, Thomas D. TI Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID DOUBLE-STRAND BREAKS; HEMATOPOIETIC MALIGNANCIES; SACCHAROMYCES-CEREVISIAE; REARRANGEMENTS; REPAIR; REPLICATION; GENE; BREAKPOINTS; ABERRATIONS; EXPRESSION AB Specific regions of genomes (fragile sites) are hot spots for the chromosome rearrangements that are associated with many types of cancer cells. Understanding the molecular mechanisms regulating the stability of chromosome fragile sites, therefore, has important implications in cancer biology. We previously identified two chromosome fragile sites in Saccharomyces cerevisiae that were induced in response to the reduced expression of Pol1p, the catalytic subunit of DNA polymerase alpha. In the study presented here, we show that reduced levels of Pol3p, the catalytic subunit of DNA polymerase delta, induce instability at these same sites and lead to the generation of a variety of chromosomal aberrations. These findings demonstrate that a change in the stoichiometry of replicative DNA polymerases results in recombinogenic DNA lesions, presumably double-strand DNA breaks. C1 [Lemoine, Francene J.; Degtyareva, Natasha P.; Petes, Thomas D.] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA. [Kokoska, Robert J.] USA, Res Off, Div Life Sci, Res Triangle Pk, NC 27709 USA. RP Lemoine, FJ (reprint author), NW State Univ Louisiana, Dept Biol Sci, Natchitoches, LA 71497 USA. EM lemoinef@nsula.edu FU NIH [GM52319]; Leukemia and Lymphoma Society [3427-07] FX We thank Malgorzata Gawel for assistance with the Southern blots and CGH microarray analysis; Jennifer Gerton, Phoebe Lee, and Jeremy DeMai for strain constructions; and all members of the Petes lab for useful discussions. We also thank Abram Gabriel for sharing unpublished information.; The research was supported by an NIH grant to T.D.P. (GM52319) and a grant from the Leukemia and Lymphoma Society to F.J.L. (3427-07). NR 29 TC 33 Z9 33 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD SEP PY 2008 VL 28 IS 17 BP 5359 EP 5368 DI 10.1128/MCB.02084-07 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 341DY UT WOS:000258695600019 PM 18591249 ER PT J AU Niu, ZW Bruckman, MA Harp, B Mello, CM Wang, Q AF Niu, Zhongwei Bruckman, Michael A. Harp, Brandon Mello, Charlene M. Wang, Qian TI Bacteriophage M13 as a Scaffold for Preparing Conductive Polymeric Composite Fibers SO NANO RESEARCH LA English DT Article DE Bacteriophage M13; nanofiber; conductive polymer; self-assembly; bioconjugation AB Using biological templates to build one-dimensional functional materials holds great promise in developing nanosized electrical devices, sensors, catalysts, and energy storage units. In this communication, we report a versatile assembly process for the preparation of water-soluble conductive polyaniline (PANi)/M13 composite nanowires by employing the bacteriophage M13 as a template. The surface lysine residues of M13 can be derivatized with carboxylic groups to improve its binding ability to the aniline; the resulting modified M13 is denoted as m-M13. Highly negatively-charged poly(sulfonated styrene) was used both as a dopant acid and a stabilizing agent to enhance the stability of the composite fibers in aqueous solution. A transparent solution of the conductive PANi/m-M13 composite fibers can be readily obtained without any further purification step. The fibers can be easily fabricated into thin conductive films due to their high aspect ratio and good solubility in aqueous solution. This synthesis discloses a unique and versatile way of using bionanorods to produce composite fibrillar materials with narrow dispersity, high aspect ratio, and high processibility, which may have many potential applications in electronics, optics, sensing, and biomedical engineering. C1 [Mello, Charlene M.] USA, Natick Soldier Res, Ctr Dev & Engn, Biosci & Technol Team, Natick, MA 01760 USA. [Niu, Zhongwei; Bruckman, Michael A.; Harp, Brandon; Wang, Qian] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA. [Niu, Zhongwei; Bruckman, Michael A.; Harp, Brandon; Wang, Qian] Univ S Carolina, Nanoctr, Columbia, SC 29208 USA. RP Mello, CM (reprint author), USA, Natick Soldier Res, Ctr Dev & Engn, Biosci & Technol Team, Natick, MA 01760 USA. EM Charlene.Mello@us.army.mil; wang@mail.chem.sc.edu RI niu, zhongwei/C-7671-2011; OI Wang, Qian/0000-0002-2149-384X FU NSF-DMR [NSF-DMR-0706431]; NSF career award; US DoD; W. M. Keck Foundation FX We acknowledge Dr. Lynne Samuelson for her kind and extremely helpful suggestions. We are grateful for financial support from NSF-DMR-0706431, NSF career award, US DoD, and the W. M. Keck Foundation. This manuscript has been approved by the U.S. Army Natick Soldier Research, Development and Engineering Center for unlimited distribution (PAO# 08-107). NR 41 TC 24 Z9 25 U1 0 U2 30 PU TSINGHUA UNIV PRESS PI BEIJING PA TSINGHUA UNIV, RM A703, XUEYAN BLDG, BEIJING, 10084, PEOPLES R CHINA SN 1998-0124 J9 NANO RES JI Nano Res. PD SEP PY 2008 VL 1 IS 3 BP 235 EP 241 DI 10.1007/s12274-008-8027-2 PG 7 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA V10MD UT WOS:000207467200007 ER PT J AU Kudenov, MW Pezzaniti, L Dereniak, EL Gerhart, GR AF Kudenov, Michael W. Pezzaniti, Larry Dereniak, Eustace L. Gerhart, Grant R. TI Prismatic imaging polarimeter calibration for the infrared spectral region SO OPTICS EXPRESS LA English DT Article ID YTTRIUM VANADATE AB The calibration of a complete Stokes birefringent prismatic imaging polarimeter (BPIP) in the MWIR is demonstrated. The BPIP technique, originally developed by K. Oka, is implemented with a set of four Yttrium Vanadate (YVO4) crystal prisms. A mathematical model for the polarimeter is presented in which diattenuation due to Fresnel effects and dichroism in the crystal are included. An improved polarimetric calibration technique is introduced to remove the diattenuation effects, along with the relative radiometric calibration required for the BPIP operating with a thermal background and large detector offsets. Data demonstrating emission polarization are presented from various blackbodies, which are compared to data from our Fourier transform infrared spectropolarimeter. (c) 2008 Optical Society of America. C1 [Kudenov, Michael W.; Dereniak, Eustace L.] Univ Arizona, Coll Opt Sci, Tucson, AZ 85721 USA. [Pezzaniti, Larry] Polaris Sensor Technol Inc, Huntsville, AL USA. [Gerhart, Grant R.] USA, TACOM, Warren, MI 48397 USA. RP Kudenov, MW (reprint author), Univ Arizona, Coll Opt Sci, 1630 E Univ Blvd, Tucson, AZ 85721 USA. NR 12 TC 19 Z9 19 U1 0 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD SEP 1 PY 2008 VL 16 IS 18 BP 13720 EP 13737 DI 10.1364/OE.16.013720 PG 18 WC Optics SC Optics GA 349GZ UT WOS:000259270600028 PM 18772984 ER PT J AU Brodhead, MJ AF Brodhead, Michael J. TI The trans-Mississippi West, 1804-1912: A guide to federal records for the territorial period part IV, A guide to records of the dept. of the interior for the territorial period, Section 3, Records of the general land office SO OREGON HISTORICAL QUARTERLY LA English DT Book Review C1 [Brodhead, Michael J.] USA, Corps Engineers, Alexandria, VA USA. RP Brodhead, MJ (reprint author), USA, Corps Engineers, Alexandria, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OREGON HISTORICAL SOC PI PORTLAND PA 1230 SW PARK AVE, PORTLAND, OR 97205 USA SN 0030-4727 J9 OREG HIST QUART JI Oregon Hist. Q. PD FAL PY 2008 VL 109 IS 3 BP 494 EP 495 PG 2 WC History SC History GA 350LT UT WOS:000259354700016 ER PT J AU Cohen, SP Maine, DN Shockey, SM Kudchadkar, S Griffith, S AF Cohen, Steven P. Maine, David N. Shockey, Sean M. Kudchadkar, Sapna Griffith, Scott TI Inadvertent disk injection during transforaminal epidural steroid injection: Steps for prevention and management SO PAIN MEDICINE LA English DT Article DE complication; diskitis; epidural steroid injection; infection; magnetic resonance imaging ID LUMBAR DISCOGRAPHY; PROPHYLACTIC ANTIBIOTICS; DISCITIS; SURGERY AB Objectives. To report two cases of disk injection during transforaminal epidural steroid injection, and to discuss ways to prevent and manage this under-appreciated complication. Desing. Case reports and literature reviews. Patients. Two patients with radicular symptoms underwent transforaminal epidural steroid injections under fluoroscopic guidance. The needle in both cases was placed in the center of the intervertebral foramen, about 1 cm above the inferior endplate. Injection of contrast in both cases revealed diskographic spread. Repeat magnetic resonance imaging revealed a large foraminal disk herniation in both patients. Results. A literature search identified three studies whereby the use of a single-needle technique to perform diskography was clearly noted in conjunction with the number of infectious complications. Comparing these data with the incidence of diskitis when a double-needle approach was used found the infectious risk to be considerably higher. There are no data regarding whether imaging studies affect outcomes following epidural steroid injections. Conclusions. These cases and similar complications following transforaminal epidural steroid injections provide anecdotal evidence that recent imaging studies, repeated not only for qualitatively new symptoms but after a sustained quantitative increase in pain, may reduce the complication risk. Data extrapolated from studies on diskitis suggest that administering parenteral, and possibly also intradiskal antibiotics, immediately after inadvertent disk injection is appreciated, may reduce the infectious risk. C1 [Cohen, Steven P.; Maine, David N.; Kudchadkar, Sapna] Johns Hopkins Sch Med, Pain Management Div, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA. [Cohen, Steven P.; Shockey, Sean M.; Griffith, Scott] Walter Reed Army Med Ctr, Dept Surg, Anesthesia Serv, Washington, DC 20307 USA. RP Cohen, SP (reprint author), 550 N Broadway,Suite 301, Baltimore, MD 21029 USA. EM scohen40@jhmi.edu OI Kudchadkar, Sapna/0000-0003-3089-0318 NR 26 TC 17 Z9 19 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1526-2375 J9 PAIN MED JI Pain Med. PD SEP PY 2008 VL 9 IS 6 BP 688 EP 694 DI 10.1111/j.1526-4637.2008.00478.x PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 339SM UT WOS:000258597600007 PM 18657222 ER PT J AU Wood, RA Berger, M Dreskin, SC Setse, R Engler, RJM Dekker, CL Halsey, NA AF Wood, Robert A. Berger, Melvin Dreskin, Stephen C. Setse, Rosanna Engler, Renata J. M. Dekker, Cornelia L. Halsey, Neal A. CA Hypersensitivity Working Grp CISA TI An algorithm for treatment of patients with hypersensitivity reactions after vaccines SO PEDIATRICS LA English DT Article DE immunization; vaccines; hypersensitivity ID JAPANESE ENCEPHALITIS VACCINES; IMMEDIATE-TYPE REACTIONS; REPORTING SYSTEM VAERS; SAFETY DATA; VARICELLA VACCINES; RUBELLA VACCINE; GELATIN ALLERGY; ANAPHYLAXIS; CHILDREN; IGE AB Concerns about possible allergic reactions to immunizations are raised frequently by both patients/parents and primary care providers. Estimates of true allergic, or immediate hypersensitivity, reactions to routine vaccines range from 1 per 50 000 doses for diphtheria-tetanus-pertussis to similar to 1 per 500 000 to 1 000 000 doses for most other vaccines. In a large study from New Zealand, data were collected during a 5-year period on 15 marketed vaccines and revealed an estimated rate of 1 immediate hypersensitivity reaction per 450 000 doses of vaccine administered. Another large study, conducted within the Vaccine Safety Datalink, described a range of reaction rates to >7.5 million doses. Depending on the study design and the time after the immunization event, reaction rates varied from 0.65 cases per million doses to 1.53 cases per million doses when additional allergy codes were included. For some vaccines, particularly when allergens such as gelatin are part of the formulation (eg, Japanese encephalitis), higher rates of serious allergic reactions may occur. Although these per-dose estimates suggest that true hypersensitivity reactions are quite rare, the large number of doses that are administered, especially for the commonly used vaccines, makes this a relatively common clinical problem. In this review, we present background information on vaccine hypersensitivity, followed by a detailed algorithm that provides a rational and organized approach for the evaluation and treatment of patients with suspected hypersensitivity. We then include 3 cases of suspected allergic reactions to vaccines that have been referred to the Clinical Immunization Safety Assessment network to demonstrate the practical application of the algorithm. C1 [Wood, Robert A.; Halsey, Neal A.] Johns Hopkins Univ Hosp, Sch Med, Dept Pediat, Baltimore, MD 21287 USA. [Berger, Melvin] Univ Hosp Cleveland, Dept Pediat, Cleveland, OH 44106 USA. [Berger, Melvin] Univ Hosp Cleveland, Dept Med, Cleveland, OH 44106 USA. [Dreskin, Stephen C.] Univ Colorado, Hlth Sci Ctr, Div Allergy & Immunol, Denver, CO USA. [Setse, Rosanna; Halsey, Neal A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. [Engler, Renata J. M.] Walter Reed Army Med Ctr, Vaccine Healthcare Ctr Network, Washington, DC 20307 USA. [Dekker, Cornelia L.] Stanford Univ, Sch Med, Div Pediat Infect Dis, Stanford, CA 94305 USA. RP Wood, RA (reprint author), Johns Hopkins Univ Hosp, Sch Med, Dept Pediat, CMSC 1102,600 N Wolfe St, Baltimore, MD 21287 USA. EM rwood@jhmi.edu FU Centers for Disease Control and Prevention FX This study was supported by a grant from the Centers for Disease Control and Prevention through an agreement with America's Health Insurance Plans. NR 34 TC 48 Z9 54 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD SEP PY 2008 VL 122 IS 3 BP E771 EP E777 DI 10.1542/peds.2008-1002 PG 7 WC Pediatrics SC Pediatrics GA 342ZR UT WOS:000258822600086 PM 18762513 ER PT J AU Coohill, TP Sagripanti, JL AF Coohill, Thomas P. Sagripanti, Jose-Luis TI Overview of the inactivation by 254 nm ultraviolet radiation of bacteria with particular relevance to biodefense SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Review ID BACILLUS-SUBTILIS SPORES; SOLAR UV-RADIATION; HYDROGEN-PEROXIDE; VIBRIO-CHOLERAE; DNA-REPAIR; RESISTANCE; LIGHT; ANTHRACIS; WATER; PHOTOREACTIVATION AB Our goal was to ultimately predict the sensitivity of untested bacteria (including those of biodefense interest) to ultraviolet (UV) radiation. In this study, we present an overview and analysis of the relevant 254 nm data previously reported and available in the literature. The amount of variability in this data prevented us from determining an "average" response for any bacterium. Therefore, we developed particular selection criteria to include the data in our analysis and suggested future guidelines for reporting UV sensitivity results. We then compiled a table of the sensitivity to 254 nm UV for 38 bacteria and three bacterial spores. The UV sensitivity was quite similar (within 10%) among the spores of Bacillus anthracis (strains Vollum 1B and Sterne), Bacillus subtilis, and Bacillus megaterium. These data indicate that spores of B. subtilis and B. megaterium could be adequate simulants of B. anthracis spores in UVC experiments. Spores of B. anthracis, B. subtilis and B. megaterium were 5-10 times more resistant to UV than were their corresponding vegetative cells. The vegetative cells of B. anthracis showed similar UV sensitivity to those of Burkholderia pseudomallei, Shigella sonnei, and a wild-type strain of Escherichia coli. Yersinia enterocolitica and Vibrio cholerae appeared more sensitive to UV and Salmonella typhi slightly more resistant to UV than E. coli. The sensitivity (at 254 nm) of all vegetative bacteria ranged from 11 to 80 Jm(2) for a 1 Log(10) kill and from 25-200 Jm(2) for 4 Log(10) kill. C1 [Sagripanti, Jose-Luis] USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD USA. [Coohill, Thomas P.] Siena Coll, Dept Phys, Loudonville, NY USA. RP Sagripanti, JL (reprint author), USA, Edgewood Chem Biol Ctr, Res Dev & Engn Command, Aberdeen Proving Ground, MD USA. EM Joseluis.sagripanti@us.army.mil FU U. S. Department of Defense Chemical and Biological Defense; Defense Threat Reduction Agency FX This work was supported by the U. S. Department of Defense Chemical and Biological Defense program administered by the Defense Threat Reduction Agency. NR 59 TC 36 Z9 36 U1 1 U2 27 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD SEP-OCT PY 2008 VL 84 IS 5 BP 1084 EP 1090 DI 10.1111/j.1751-1097.2008.00387.x PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 342LL UT WOS:000258785500005 PM 18627518 ER PT J AU Resio, DT Westerink, JJ AF Resio, Donald T. Westerink, Joannes J. TI Modeling the physics of storm surges SO PHYSICS TODAY LA English DT Article C1 [Resio, Donald T.] USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. [Westerink, Joannes J.] Univ Notre Dame, Dept Civil Engn & Geol Sci, Notre Dame, IN 46556 USA. RP Resio, DT (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. FU System-Wide Water Resources Program; US Army Corps of Engineers; NSF [OCI-0746232] FX Both authors were supported in part by the System-Wide Water Resources Program of the US Army Corps of Engineers. The chief of engineers has granted permission for publication of the contents of this article. One of us (Westerink) was also supported in part by NSF, under grant OCI-0746232. NR 8 TC 87 Z9 88 U1 3 U2 21 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD SEP PY 2008 VL 61 IS 9 BP 33 EP 38 DI 10.1063/1.2982120 PG 6 WC Physics, Multidisciplinary SC Physics GA 346JI UT WOS:000259064400021 ER PT J AU Kumaran, D Rawat, R Ahmed, SA Swaminathan, S AF Kumaran, Desigan Rawat, Richa Ahmed, S. Ashraf Swaminathan, Subramanyam TI Substrate binding mode and its implication on drug design for botulinum neurotoxin A SO PLOS PATHOGENS LA English DT Article ID AMINO-ACID-COMPOSITION; ELECTRON-DENSITY MAPS; LIGHT-CHAIN; SEROTYPE-A; PROTEOLYTIC ACTIVITY; RECOGNITION; MECHANISM; TOXIN; PURIFICATION; INHIBITORS AB The seven antigenically distinct serotypes of Clostridium botulinum neurotoxins, the causative agents of botulism, block the neurotransmitter release by specifically cleaving one of the three SNARE proteins and induce flaccid paralysis. The Centers for Disease Control and Prevention (CDC)has declared them as Category A biowarfare agents. The most potent among them, botulinum neurotoxin type A (BoNT/A), cleaves its substrate synaptosome-associated protein of 25 kDa (SNAP-25). An efficient drug for botulism can be developed only with the knowledge of interactions between the substrate and enzyme at the active site. Here, we report the crystal structures of the catalytic domain of BoNT/A with its uncleavable SNAP-25 peptide (197)QRATKM(202) and its variant (197)RRATKM(202) to 1.5 angstrom and 1.6 angstrom, respectively. This is the first time the structure of an uncleavable substrate bound to an active botulinum neurotoxin is reported and it has helped in unequivocally defining S1 to S5 ' sites. These substrate peptides make interactions with the enzyme predominantly by the residues from 160, 200, 250 and 370 loops. Most notably, the amino nitrogen and carbonyl oxygen of P1 residue (Gln197) chelate the zinc ion and replace the nucleophilic water. The P1 '-Arg198, occupies the S1 ' site formed by Arg363, Thr220, Asp370, Thr215, Ile161, Phe163 and Phe194. The S2 ' subsite is formed by Arg363, Asn368 and Asp370, while S3 ' subsite is formed by Tyr251, Leu256, Val258, Tyr366, Phe369 and Asn388. P4 '-Lys201 makes hydrogen bond with Gln162. P5 '-Met202 binds in the hydrophobic pocket formed by the residues from the 250 and 200 loop. Knowledge of interactions between the enzyme and substrate peptide from these complex structures should form the basis for design of potent inhibitors for this neurotoxin. C1 [Kumaran, Desigan; Rawat, Richa; Swaminathan, Subramanyam] Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. [Ahmed, S. Ashraf] USA, Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD USA. RP Swaminathan, S (reprint author), Brookhaven Natl Lab, Dept Biol, Upton, NY 11973 USA. EM swami@bnl.gov FU JSTO-CBD [3.10012_06_RD_B]; DOE Prime [DEAC02-98CH10886]; US Army [DAMD17-02-2-0011] FX This project was supported by a JSTO-CBD (Project # 3.10012_06_RD_B) funding to S. Ashraf Ahmed. Sub-contract to BNL (S. Swaminathan) was through MIPR N0. 8CO890039 under DOE Prime Contract No. DEAC02-98CH10886 with Brookhaven National Laboratory. S. Swaminathan also received partial funding from the US Army (DAMD17-02-2-0011). NR 38 TC 34 Z9 34 U1 2 U2 6 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1553-7366 J9 PLOS PATHOG JI PLoS Pathog. PD SEP PY 2008 VL 4 IS 9 AR e1000165 DI 10.1371/journal.ppat.1000165 PG 9 WC Microbiology; Parasitology; Virology SC Microbiology; Parasitology; Virology GA 356MW UT WOS:000259783300022 PM 18818739 ER PT J AU Gore, KL AF Gore, Kristie L. TI Treating Somatization: A Cognitive Behavioral Approach SO PSYCHIATRY-INTERPERSONAL AND BIOLOGICAL PROCESSES LA English DT Book Review ID POSTCONCUSSION SYNDROME; CHRONIC PAIN; THERAPY; ACCEPTANCE; SYMPTOMS; DISORDER; ANXIETY; VALUES; FEAR C1 [Gore, Kristie L.] Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. RP Gore, KL (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM Kristie.Gore@amedd.army.mil NR 19 TC 0 Z9 0 U1 0 U2 3 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 USA SN 0033-2747 J9 PSYCHIATRY JI Psychiatry-Interpers. Biol. Process. PD FAL PY 2008 VL 71 IS 3 BP 277 EP 282 PG 6 WC Psychiatry SC Psychiatry GA 365NF UT WOS:000260413000008 ER PT J AU Ferrero-Serrano, A Collier, TR Hild, AL Mealor, BA Smith, T AF Ferrero-Serrano, Angel Collier, Timothy R. Hild, Ann L. Mealor, Brian A. Smith, Thomas TI Combined impacts of native grass competition and introduced weevil herbivory on Canada thistle (Cirsium arvense) SO RANGELAND ECOLOGY & MANAGEMENT LA English DT Article DE biological control; Ceutorhynchus litura; Hesperostipa comata; integrated pest management (IPM); Sporobolus airoides; synergism; weevil ID RUBIGINOSA MULLER COLEOPTERA; BIOLOGICAL-CONTROL AGENTS; CEUTORHYNCHUS-LITURA; CENTAUREA-MACULOSA; PLANT COMPETITION; L SCOP; BIOCONTROL; SELECTION; GROWTH; CHRYSOMELIDAE AB Invading exotics typically face new competitors and an absence of specialized herbivores in their new ranges. Biological control attempts to reunite invasive weeds with coevolved herbivores and restoration can reduce the return of invaders by maximizing competition from native species. The integration of both approaches is seldom examined in detail, although the two should complement each other. We investigated the potential to suppress an important invasive plant, Canada thistle (Cirsium arvense [L.] Scop.), by integrating biological control and competition from two native grasses frequently used in rangeland restoration. We evaluated the impacts of Ceutorhynchus litura F. (Coleoptera: Curculionidae), a weevil used for Canada thistle biological control, alone and in combination with either needle and thread grass (Hesperostipa comata [Trin. & Rupr.] Barkworth) or alkali sacaton (Sporobolus airoides [Torr.] Torr.) in greenhouse competitive plantings. Weevil herbivory reduced root, but not shoot, biomass of Canada thistle. Competition from H. comata did not reduce biomass of thistles, but combinations of the weevil and H. comata greatly reduced thistle root biomass. S. airoides suppressed Canada thistle root biomass independent of weevils. Weevils had a positive indirect effect on the cool-season grass H. comata, presumably by reducing the competitive ability of thistles, but had no effect on biomass of the warm-season grass, S. airoides. Benefits of weevil presence as in augmentation of grass competition appear to depend on appropriate timing, and weevils provided the most benefit to the cool-season competitor. Our results suggest that restoration efforts can be complemented with insect biocontrol agents, although the timing of impact will depend on the particular weed species, grass competitors, and biocontrol insect agents involved. C1 [Hild, Ann L.] Univ Wyoming, Dept Renewable Resources, Dept 3354, Laramie, WY 82071 USA. [Mealor, Brian A.] Nature Conservancy, Lander, WY 82520 USA. [Smith, Thomas] US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. RP Hild, AL (reprint author), Univ Wyoming, Dept Renewable Resources, Dept 3354, 1000 E Univ Ave, Laramie, WY 82071 USA. EM annhild@uwyo.edu NR 33 TC 14 Z9 14 U1 2 U2 15 PU SOC RANGE MANAGEMENT PI LAKEWOOD PA 445 UNION BLVD, STE 230, LAKEWOOD, CO 80228-1259 USA SN 1550-7424 J9 RANGELAND ECOL MANAG JI Rangel. Ecol. Manag. PD SEP PY 2008 VL 61 IS 5 BP 529 EP 534 DI 10.2111/07-142R.1 PG 6 WC Ecology; Environmental Sciences SC Environmental Sciences & Ecology GA 351FH UT WOS:000259409400007 ER PT J AU Smith, R AF Smith, Roger TI Harnessing competencies capabilities and resource SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Article DE strategic alignment; core competency; corporate resources AB The importance of identifying and fostering corporate "capabilities" has been confused with creating competencies. Competencies are unique products or services, often created in the R&D labs, which can penetrate existing markets. Capabilities are the operational ability to deliver those new products and services efficiently, repeatedly and in sufficient volume. Capabilities and competencies are both required to succesfully place a product in the market. These must also be supported by corporate resources to ensure longevity. The importance of aligning competencies, capabilities and resources can be explained through the analogy of an axe blade splitting dense wood. C1 [Smith, Roger] USA, Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), USA, Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 13 TC 1 Z9 1 U1 1 U2 3 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD SEP-OCT PY 2008 VL 51 IS 5 BP 47 EP 53 PG 7 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 340UV UT WOS:000258671400012 ER PT J AU Smith, R AF Smith, Roger TI Where do they find the time? SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Editorial Material C1 [Smith, Roger] USA, Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), USA, Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com NR 3 TC 0 Z9 0 U1 0 U2 0 PU INDUSTRIAL RESEARCH INST, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD SEP-OCT PY 2008 VL 51 IS 5 BP 67 EP 68 PG 2 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 340UV UT WOS:000258671400015 ER PT J AU Evans, SD Adams, NS Rondorf, DW Plumb, JM Ebberts, BD AF Evans, Scott D. Adams, Noah S. Rondorf, Dennis W. Plumb, John M. Ebberts, Blaine D. TI Performance of a prototype surface collector for juvenile salmonids at Bonneville Dam's First Powerhouse on the Columbia River, Oregon SO RIVER RESEARCH AND APPLICATIONS LA English DT Article DE surface bypass; fish passage; juvenile Chinook salmon; juvenile steelhead; radio telemetry; Bonneville Dam; Columbia River ID IMPLANTED RADIO TRANSMITTERS; YEARLING CHINOOK SALMON; SNAKE RIVER; ONCORHYNCHUS-TSHAWYTSCHA; BYPASS SYSTEM; WELLS DAM; BEHAVIOR; STEELHEAD; MIGRATION; WASHINGTON AB During April-July 2000, we radio-tagged and released juvenile Chinook salmon (Oncorhynchus tshawytscha) and steelhead (Oncorhynchus mykiss) to evaluate a prototype surface flow, bypass at Bonneville Dam oil the Columbia River. The mock bypass. called a prototype surface collector (PSC), had six vertical slot entrances that were each 6 m wide and 12 in deep. The PSC was retrofitted to the upstream face of Bonneville Dam's First Powerhouse. Our objectives were to: (I) assess species-specific differences in movement patterns and behaviour of fish within 6 in of the face of the PSC, (2) estimate the efficiency and effectiveness of the PSC and (3) evaluate factors affecting the performance of the PSC. WC found that 60-72% of the fish, depending on species. detected within 6 m of the PSC entered it. Of the fish that passed the First Powerhouse at turbines 1-6, 79-83% entered the PSC. Diel period was a significant contributor to PSC performance for all species, and day of year was a significant contributor to PSC performance for subyearling Chinook salmon. The PSC was twice as effective (%fish/%flow) as the spillway, passing 2.5:1 steelhead and subyearling Chinook salmon and 2.4:1 yearling Chinook salmon per unit of water. If fully implemented. the PSC would increase the percentage of fish that pass the First Powerhouse through non-turbine routes from 65-77% (without the PSC) to 76-85% (with the PSC), depending on species. Published in 2008 by John Wiley & Sons, Ltd. C1 [Evans, Scott D.; Adams, Noah S.; Rondorf, Dennis W.; Plumb, John M.] US Geol Survey, Columbia River Res Lab, Western Fisheries Res Ctr, Cook, WA 98605 USA. [Ebberts, Blaine D.] USA Corps Engineers, Environm Resources Branch, Portland, OR 97204 USA. RP Evans, SD (reprint author), US Geol Survey, Columbia River Res Lab, Western Fisheries Res Ctr, 5501 A Cook Underwood Rd, Cook, WA 98605 USA. EM sdevans@usgs.gov FU The Portland District U.S. Army Corps of Engineers (USACE); Pacific Northwest Division FX The Portland District U.S. Army Corps of Engineers (USACE) funded this study under the Anadromous Fish Evaluation Programme, Pacific Northwest Division. We thank USACE staff at Bonneville Dam and in Portland, Oregon for logistic and programmatic assistance. We appreciate the efforts of Gary Johnson (Northwest National Laboratory), John Beeman and Dena Gadomski (U.S. Geological Survey (USGS)) and two anonymous reviewers for their critical review of this manuscript. We thank Cliff Pereira, Oregon State University, for his constructive comments and critical review of our analysis of fish passage data over the years. The use of trade, firm or corporation names in this publication is for the information and convenience of the reader. Such use does not constitute an official endorsement or approval by the U.S. Department of Interior or the USGS of any product or service to the exclusion of others that may be suitable. NR 58 TC 8 Z9 8 U1 2 U2 12 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1535-1459 J9 RIVER RES APPL JI River Res. Appl. PD SEP PY 2008 VL 24 IS 7 BP 960 EP 974 DI 10.1002/rra.1113 PG 15 WC Environmental Sciences; Water Resources SC Environmental Sciences & Ecology; Water Resources GA 353RC UT WOS:000259584900006 ER PT J AU Lettieri, CJ Quast, TN Eliasson, AH Andrada, T AF Lettieri, Christopher J. Quast, Timothy N. Eliasson, Arn H. Andrada, Teotimo TI Eszopiclone improves overnight polysomnography and continuous positive airway pressure titration: A prospective, randomized, placebo-controlled trial SO SLEEP LA English DT Article DE eszopiclone; polysomnography; sleep study; sleep latency; sleep efficiency; CPAP titration; quality ID SLEEP-APNEA SYNDROME; CHRONIC INSOMNIA; DOUBLE-BLIND; ZOLPIDEM; EFFICACY; ADULTS; TRANSIENT; SAFETY AB Study Objectives: To assess whether premedication with eszopiclone would improve sleep duration and continuity during polysomnography, thereby improving the quality of diagnostic and CPAP titration studies. Design: Prospective, double-blinded, placebo-controlled trial Setting: Academic, multidisciplinary sleep center. Patients: 226 adult subjects undergoing polysomnography for suspected sleep disordered breathing; 113 received eszopiclone and 113 received placebo. Interventions: Subjects received eszopiclone 3 mg or matching placebo before polysomnography. We compared sleep latency, efficiency, total sleep time, and apnea-hypopnea index between these groups. We also compared rates of inadequate studies, defined as insufficient sleep time (< 120 min or sleep efficiency <= 70%) or incomplete CPAP titrations (>= 5 events/h on the highest CPAP or complete intolerance). Measurements and Results: Eszopiclone premedication significantly improved a number of measured variables. Eszopiclone reduced sleep latency (21.7 +/- 27.1 vs. 32.6 +/- 38.2 min, P = 0.014), improved sleep efficiency (87.6% +/- 10.8% vs. 78.1% +/- 15.6%, P < 0.001), reduced wake after sleep onset (39.2 +/- 31.9 vs. 64.5 +/- 45.4 min, P < 0.001) and prolonged sleep time (346.5 +/- 53.1 vs. 312.2 +/- 64.2 min, P < 0.001). Sleep efficiencies <= 70% were more common with placebo than medication (21.2% vs. 7.1%, P = 0.004). Eszopiclone facilitated improved CPAP titrations with fewer residual events (5.7 +/- 10.3 vs. 11.9 +/- 19.6, P = 0.02) and fewer incomplete titrations (31.1% vs. 48.0%, P = 0.04). Poor quality studies (46.0% vs. 26.5%, P = 0.004) were more common with placebo than with eszopiclone. There was a trend for more nonusable studies with placebo (7.1% vs. 2.7%, P = 0.22). Side effects were uncommon and did not differ between groups. Conclusion: Pretreatment with eszopiclone improves the quality of polysomnography and CPAP titration and decreases the need to repeat studies. Given the ever-growing demand for polysomnography and the need to improve efficiency, the routine use of nonbenzodiazepines as premedication for polysomnography should be considered. C1 [Lettieri, Christopher J.; Quast, Timothy N.; Eliasson, Arn H.; Andrada, Teotimo] Walter Reed Army Med Ctr, Pulm Crit Care & Sleep Med Serv, Dept Med, Washington, DC 20307 USA. [Lettieri, Christopher J.; Eliasson, Arn H.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA. RP Lettieri, CJ (reprint author), Walter Reed Army Med Ctr, Pulm Crit Care & Sleep Med Serv, Dept Med, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM christopher.lettieri@us.army.mil FU National Clinical Trials Registry [NCT00507117] FX National Clinical Trials Registry: NCT00507117 NR 19 TC 20 Z9 23 U1 0 U2 1 PU AMER ACAD SLEEP MEDICINE PI WESTCHESTER PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA SN 0161-8105 J9 SLEEP JI Sleep PD SEP 1 PY 2008 VL 31 IS 9 BP 1310 EP 1316 PG 7 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA 343YA UT WOS:000258891100014 PM 18788656 ER PT J AU Freedman, BA Potter, BK Nesti, LJ Giuliani, JR Hampton, C Kuklo, TR AF Freedman, Brett A. Potter, Benjamin K. Nesti, Leon J. Giuliani, Jeffrey R. Hampton, Chadwick Kuklo, Timothy R. TI Osteoporosis and vertebral compression fractures-continued missed opportunities SO SPINE JOURNAL LA English DT Article DE osteoporosis; fragility; fracture; vertebral; compression; incidence ID VITAMIN-D SUPPLEMENTATION; HIP FRACTURE; POSTMENOPAUSAL WOMEN; BONE-DENSITY; RISK; CALCIUM; ALENDRONATE; PREVENTION; PHYSICIANS; TRIAL AB BACKGROUND CONTEXT: Untreated osteoporosis causes decreased bone mineral density, which predisposes to fragility fractures. Low-energy vertebral compression fractures are the most common type of osteoporotic fragility fracture. Prior studies have shown that only one-quarter of patients diagnosed with an osteoporotic fracture are referred or treated for osteoporosis. PURPOSE: To identify the rate of therapeutic interventions for patients aged 50 years and older within a capitated population who sustained low impact vertebral compression fractures over a 6-month period. STUDY DESIGN/SETTING: Retrospective observational study. PATIENT SAMPLE: The reports of all imaging studies of the chest, abdomen, and spine taken from July to December 2002 within a large military health-care system were queried on the Composite Health Computer System (CHCS). The sample included patients 50 years or older who had a low-energy vertebral compression fracture. OUTCOME MEASURES: The computerized medical records were examined for osteoporotic medication prescriptions, referrals to endocrinology, and to dual-energy X-ray absorptiometry (DEXA) scans. These results were compared with results obtained from a similar study on osteoporotic distal radius fractures. RESULTS: The records of 156 patients (average age: 77.3 y; 78 women, 78 men) meeting the inclusion criteria were analyzed to determine what proportion was followed-up with osteoporosis interventions. Within I year after the fracture, 39% (37 females, 24 males) had undergone a DEXA scan, 35% (37 females, 18 males) had been referred to endocrinology, 38% (47 females, 12 males) were receiving active osteoporosis treatment, and 51% (55 females, 25 males) were receiving any form of osteoporosis-directed medication. The rate of medical intervention was similar to the rate of intervention after distal radius fragility fractures (n =111; 30% active medication; 47% any osteoporosis medication) (p>.21). The rate of all interventions was significantly greater for women than men. CONCLUSIONS: Although the likelihood of intervention is slightly greater after vertebral compression fractures than for distal radius fractures, orthopedic surgeons, emergency room physicians, and primary care providers continue to miss opportunities, especially in males, to diagnose and/or initiate active therapeutic interventions for osteoporosis in patients presenting with osteoporosis-related fragility fractures. Published by Elsevier Inc. C1 [Freedman, Brett A.; Potter, Benjamin K.; Nesti, Leon J.; Giuliani, Jeffrey R.; Hampton, Chadwick; Kuklo, Timothy R.] Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabil, Washington, DC 20307 USA. RP Freedman, BA (reprint author), 230 E Ponce De Leon Ave, Decatur, GA 30030 USA. EM brettfreedman@yahoo.com OI Potter, MD, Benjamin K./0000-0002-8771-0317 NR 25 TC 16 Z9 16 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 1529-9430 J9 SPINE J JI Spine Journal PD SEP-OCT PY 2008 VL 8 IS 5 BP 756 EP 762 DI 10.1016/j.spinee.2008.01.013 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 352ZD UT WOS:000259535000008 PM 18343730 ER PT J AU Nesti, LJ Li, WJ Shanti, RM Jiang, YJ Jackson, W Freedman, BA Kuklo, TR Giuliani, JR Tuan, RS AF Nesti, Leon J. Li, Wan-Ju Shanti, Rabie M. Jiang, Yi Jen Jackson, Wesley Freedman, Brett A. Kuklo, Timothy R. Giuliani, Jeffrey R. Tuan, Rocky S. TI Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam SO TISSUE ENGINEERING PART A LA English DT Article ID MESENCHYMAL STEM-CELLS; INVESTIGATIONAL DEVICE EXEMPTION; NUCLEUS PULPOSUS; IN-VITRO; TRANSPLANTATION THERAPY; SOLUTE TRANSPORT; LUMBAR FUSION; BACK-PAIN; FOLLOW-UP; DIFFERENTIATION AB Degeneration of the intervertebral disc (IVD) represents a significant musculoskeletal disease burden. Although spinal fusion has some efficacy in pain management, spine biomechanics is ultimately compromised. In addition, there is inherent limitation of hardware-based IVD replacement prostheses, which underscores the importance of biological approaches to disc repair. In this study, we have seeded multipotent, adult human mesenchymal stem cells (MSCs) into a novel biomaterial amalgam to develop a biphasic construct that consisted of electrospun, biodegradable nanofibrous scaffold (NFS) enveloping a hyaluronic acid (HA) hydrogel center. The seeded MSCs were induced to undergo chondrogenesis in vitro in the presence of transforming growth factor-beta for up to 28 days. The cartilaginous hyaluronic acid nanofibrous scaffold (HANFS) construct architecturally resembled a native IVD, with an outer annulus fibrosus-like region and inner nucleus pulposus-like region. Histological and biochemical analyses, immunohistochemistry, and gene expression profiling revealed the time-dependent development of chondrocytic phenotype of the seeded cells. The cells also maintain the microarchitecture of a native IVD. Taken together, these findings suggest the prototypic potential of MSC-seeded HANFS constructs for the tissue engineering of biological replacements of degenerated IVD. C1 [Nesti, Leon J.; Li, Wan-Ju; Shanti, Rabie M.; Jiang, Yi Jen; Jackson, Wesley; Tuan, Rocky S.] NIAMSD, NIH, Dept Hlth & Human Serv, Cartilage Biol & Orthopaed Branch, Bethesda, MD 20892 USA. [Nesti, Leon J.; Freedman, Brett A.; Kuklo, Timothy R.; Giuliani, Jeffrey R.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. [Shanti, Rabie M.] NIH, Howard Hughes Med Inst, Res Scholars Program, Bethesda, MD 20892 USA. RP Tuan, RS (reprint author), NIAMSD, NIH, Dept Hlth & Human Serv, Cartilage Biol & Orthopaed Branch, Bldg 50,Room 1503,MSC 8022, Bethesda, MD 20892 USA. EM tuanr@mail.nih.gov FU NIAMS; NIH [ZO1 AR41131] FX This work was supported by the Intramural Research Program of the NIAMS, NIH (ZO1 AR41131). NR 61 TC 96 Z9 105 U1 2 U2 19 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1937-3341 J9 TISSUE ENG PT A JI Tissue Eng. Part A PD SEP PY 2008 VL 14 IS 9 SI SI BP 1527 EP 1537 DI 10.1089/ten.tea.2008.0215 PG 11 WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology SC Cell Biology; Biotechnology & Applied Microbiology GA 350UG UT WOS:000259378000010 PM 18707229 ER PT J AU Maxwell, DM Koplovitz, I Worek, F Sweeney, RE AF Maxwell, Donald M. Koplovitz, Irwin Worek, Franz Sweeney, Richard E. TI A structure-activity analysis of the variation in oxime efficacy against nerve agents SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article DE organophosphorus nerve agents; acetylcholinesterase; oxime; steric hindrance ID INHIBITED HUMAN CHOLINESTERASES; ORGANOPHOSPHORUS COMPOUNDS; PYRIDINIUM-OXIMES; BISPYRIDINIUM OXIMES; ACETYLCHOLINESTERASE; REACTIVATION; SOMAN; CARBOXYLESTERASE; PROTECTION; TOXICITY AB A structure-activity analysis was used to evaluate the variation in oxime efficacy of 2-PAM, obidoxime, HI-6 and ICD585 against nerve agents. In vivo oxime protection and in vitro oxime reactivation were used as indicators of oxime efficacy against VX, satin, VR and cyclosarin. Analysis of in vivo oxime protection was conducted with oxime protective ratios (PR) from guinea pigs receiving oxime and atropine therapy after sc administration of nerve agent. Analysis of in vitro reactivation was conducted with second-order rate contants (k(r2)) for oxime reactivation of agent-inhibited acetylcholinesterase (AChE) from guinea pig erythrocytes, In vivo oxime PR and in vitro k(r2) decreased as the volume of the alkylmethylphosphonate moiety of nerve agents increased from VX to cyclosarin. This effect was greater with 2-PAM and obidoxime (> 14-fold decrease in PR) than with HI-6 and ICD585 (<3.7-fold decrease in PR). The decrease in oxime PR and k(r2) as the volume of the agent moiety conjugated to AChE increased was consistent with a steric hindrance mechanism. Linear regression of log (PR-1) against log (k(r2).[oxime dose]) produced two offset parallel regression lines that delineated a significant difference between the coupling of oxime reactivation and oxime protection for HI-6 and ICD585 compared to 2-PAM and obidoxime. HI-6 and ICD585 appeared to be 6.8-fold More effective than 2-PAM and obidoxime at coupling oxime reactivation to oxime protection, which suggested that the isonicotinamide group that is common to both of these oximes, but absent from 2-PAM and obidoxime, is important for oxime efficacy. Published by Elsevier Inc. C1 [Maxwell, Donald M.; Koplovitz, Irwin; Sweeney, Richard E.] USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen Proving Ground, MD 21010 USA. [Worek, Franz] Bundeswehr Inst Pharmacol & Toxicol, Munich, Germany. RP Maxwell, DM (reprint author), USA, Med Res Inst Chem Def, Div Res, Pharmacol Branch, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA. EM donald.maxwell@amedd.army.mil OI Worek, Franz/0000-0003-3531-3616 FU Defense Threat Reduction Agency; Joint Science and Technology Office; Medical S T Division FX This research was supported by the Defense Threat Reduction Agency - Joint Science and Technology Office, Medical S & T Division. This agency had no involvement in the execution of the research described in this report, the writing of this report or the decision to submit this report for publication. NR 52 TC 47 Z9 50 U1 0 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD SEP 1 PY 2008 VL 231 IS 2 BP 157 EP 164 DI 10.1016/j.taap.2008.04.007 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA 350DU UT WOS:000259333600004 PM 18508103 ER PT J AU Hattersley, IJ Jenner, J Dalton, C Chilcott, RP Graham, JS AF Hattersley, I. J. Jenner, J. Dalton, C. Chilcott, R. P. Graham, J. S. TI The skin reservoir of sulphur mustard SO TOXICOLOGY IN VITRO LA English DT Article DE dermal; skin; reservoir; sulphur mustard ID IN-VITRO; ABSORPTION AB Studies of the percutaneous reservoir of sulphur mustard (HD) formed during absorption carried out during WWI and WWII are inconclusive. More recent studies have indicated that a significant amount of HD remains in human epidermal membranes during percutaneous penetration studies in vitro. present study investigated the nature and persistence of the HD reservoir formed during in vitro penetration studies using dermatomed slices of human and pig skin (0.5 mm thick). Amounts of C-14-HD that penetrated, (b) remained on the surface, (c) were extractable from and (d) remained in the skin after were estimated by liquid scintillation counting (confirmed using GC-MS analysis). results demonstrated that there is a reservoir of HD in human and pig skin for up to 24 h after contamination of the skin surface in vitro with liquid agent. At least some of this reservoir could be extracted acetonitrile, and the amounts of extracted and unextracted HD exceed the amount required to produce injury in vivo by at least 20 fold. The study demonstrated the presence of a reservoir whether the was covered (occluded) or left open to the air (unoccluded). study concluded that the extractable reservoir was significant in terms of the amount of HID required induce a vesicant response in human skin. The extractable reservoir was at least 20 times the amount per cm(2) estimated to cause a response in all of the human population, as defined by studies carried out in human volunteers during the 1940s. (C) 2008 Elsevier Ltd. All rights reserved. C1 [Hattersley, I. J.; Jenner, J.; Dalton, C.] Dstl Porton Down, Biomed Syst, Dstl Biomed Sci Dept, Salisbury SP4 0JQ, Wilts, England. [Chilcott, R. P.] Natl Radiol Protect Board, Chem Hazards & Poisons Div HQ, Didcot OX11 0RQ, Oxon, England. [Graham, J. S.] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Hattersley, IJ (reprint author), Dstl Porton Down, Biomed Syst, Dstl Biomed Sci Dept, Salisbury SP4 0JQ, Wilts, England. EM ijhattersley@dstl.gov.uk RI Dalton, Christopher/J-5747-2016 OI Dalton, Christopher/0000-0001-7021-781X FU US Army Medical Research and Materiel Command [W91ZLK-04-P-1273] FX This work was supported by the US Army Medical Research and Materiel Command under Contract # W91ZLK-04-P-1273. NR 14 TC 18 Z9 18 U1 1 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD SEP PY 2008 VL 22 IS 6 BP 1539 EP 1546 DI 10.1016/j.tiv.2008.06.002 PG 8 WC Toxicology SC Toxicology GA 353DW UT WOS:000259547300017 PM 18598749 ER PT J AU Cardo, L Wilder, D AF Cardo, L. Wilder, D. TI Accumulation of thrombospondin-1 (TSP-1) in packed red blood cells is reduced by whole blood leukoreduction filters SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. EM donna.wilder@na.amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 34A EP 34A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400096 ER PT J AU Cardo, L Wilder, D Doane, S Reddy, H Fitzpatrick, C Goodrich, R AF Cardo, L. Wilder, D. Doane, S. Reddy, H. Fitzpatrick, C. Goodrich, R. TI Annexin V binding to stored RBC after pathogen inactivation of whole blood with riboflavin and UV light SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Reddy, H.; Goodrich, R.] LLC, Navigant Biotechnol, Lakewood, CO USA. EM ray.goodrich@navigantbiotech.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 86A EP 86A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400252 ER PT J AU Cardo, L Hmel, P Wilder, D Buytaert-Hoefen, K Goodrich, R AF Cardo, L. Hmel, P. Wilder, D. Buytaert-Hoefen, Kimberley Goodrich, R. TI Fresh frozen plasma derived from whole blood treated with pathogen inactivation by riboflavin and ultraviolet light SO TRANSFUSION LA English DT Meeting Abstract CT 61st Annual Meeting of the American-Association-of-Blood-Banks and TXPO CY OCT 04-07, 2008 CL Montreal, CANADA SP Amer Assoc Blood Banks C1 [Cardo, L.; Hmel, P.; Wilder, D.] Walter Reed Army Inst Res, Silver Spring, MD USA. [Goodrich, R.] LLC, Navigant Biotechnol, Lakewood, CO USA. EM ray.goodrich@navigantbiotech.com NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 2008 VL 48 IS 2 SU S BP 87A EP 87A PG 1 WC Hematology SC Hematology GA 347CO UT WOS:000259118400255 ER EF