FN Thomson Reuters Web of Science™ VR 1.0 PT J AU Chung, KK Grathwohl, KW Poropatich, RK Wolf, SE Holcomb, JB AF Chung, Kevin K. Grathwohl, Kurt W. Poropatich, Ron K. Wolf, Steven E. Holcomb, John B. TI Robotic telepresence: Past, present, and future SO JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA LA English DT Article ID INTENSIVE-CARE-UNIT; TELEMEDICINE PROGRAM; TRAUMA CARE; STROKE; PARADIGM C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. USA Med Res & Mat Command, Ft Detrick, MD USA. RP Chung, KK (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, San Antonio, TX 78234 USA. EM kevin.chung@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 25 TC 12 Z9 13 U1 0 U2 1 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1053-0770 J9 J CARDIOTHOR VASC AN JI J. Cardiothorac. Vasc. Anesth. PD AUG PY 2007 VL 21 IS 4 BP 593 EP 596 DI 10.1053/j.jvca.2007.04.013 PG 4 WC Anesthesiology; Cardiac & Cardiovascular Systems; Respiratory System; Peripheral Vascular Disease SC Anesthesiology; Cardiovascular System & Cardiology; Respiratory System GA 200LY UT WOS:000248766100026 PM 17678796 ER PT J AU Green-Golan, L Yates, C Drinkard, B VanRyzin, C Eisenhofer, G Weise, M Merke, DP AF Green-Golan, Liza Yates, Catherine Drinkard, Bart VanRyzin, Carol Eisenhofer, Graeme Weise, Martina Merke, Deborah P. TI Patients with classic congenital adrenal hyperplasia have decreased epinephrine reserve and defective glycemic control during prolonged moderate-intensity exercise SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID 21-HYDROXYLASE DEFICIENCY; ADRENALECTOMIZED HUMANS; CHILDREN; STRESS; ADRENOMEDULLARY; SUPPRESSION; DISEASE; SYSTEM; AGE AB Context: Patients with classic congenital adrenal hyperplasia (CAH) have adrenomedullary dysplasia and hypofunction, and their lack of adrenomedullary reserve has been associated with a defective glucose response to brief high-intensity exercise. Objective: Our objective was to assess hormonal, metabolic, and cardiovascular response to prolonged moderate-intensity exercise comparable to brisk walking in adolescents with classic CAH. Subjects and Methods: We compared six adolescents with classic CAH (16-20 yr old) with seven age-, sex-, and body mass index group- matched controls (16-23 yr old) using a 90-min standardized ergometer test. Metabolic, hormonal, and cardiovascular parameters were studied during exercise and recovery. Results: Glucose did not change throughout exercise and recovery for controls, whereas CAH patients showed a steady decline in glucose during exercise with an increase in glucose in the postexercise period. Glucose levels were significantly lower in CAH patients at 60 (P = 0.04), 75 (P = 0.01), and 90 (P = 0.03) min of exercise and 15 (P = 0.02) min post exercise, whereas glucose levels were comparable between the two groups early in exercise and at 30 min (P = 0.19) post exercise. As compared with controls, CAH patients had significantly lower epinephrine (P = 0.002) and cortisol (P <= 0.001) levels throughout the study and similar norepinephrine, glucagon, and GH levels. Patients with CAH and controls had comparable cardiovascular parameters and perceived level of exertion. Despite having lower glucose levels, insulin levels were slightly higher in CAH patients during the testing period (P = 0.17), suggesting insulin insensitivity. Conclusion: CAH patients have defective glycemic control and altered metabolic and hormonal responses during prolonged moderate-intensity exercise comparable to brisk walking. C1 Ctr Clin, NIH, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NICHHD, Dept Rehabil Med, Clin Neurocardiol Sect, NINDS,Reprod Biol & Med Branch,NIH, Bethesda, MD 20892 USA. RP Merke, DP (reprint author), Ctr Clin, NIH, Bldg 10-CRC,Room 1-2740, Bethesda, MD 20892 USA. EM dmerke@mail.nih.gov FU Intramural NIH HHS NR 28 TC 18 Z9 18 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD AUG PY 2007 VL 92 IS 8 BP 3019 EP 3024 DI 10.1210/jc.2007-0493 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA 197QK UT WOS:000248570600029 PM 17535996 ER PT J AU Klungthong, C Gibbons, RV Thaisomboonsuk, B Nisalak, A Kalayanarooj, S Thirawuth, V Nutkumhang, N Mammen, MP Jarman, RG AF Klungthong, Chonticha Gibbons, Robert V. Thaisomboonsuk, Butsaya Nisalak, Ananda Kalayanarooj, Siripen Thirawuth, Vipa Nutkumhang, Naowayubol Mammen, Mammen P., Jr. Jarman, Richard G. TI Dengue virus detection using whole blood for reverse transcriptase PCR and virus isolation SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEMORRHAGIC-FEVER; CLINICAL-SAMPLES; VACCINE; INFECTIONS; LEUKOCYTES; DIAGNOSIS; MOSQUITOS; CHILDREN; ANTIBODY; VIREMIA AB Dengue is one of the most important diseases in the tropical and subtropical regions of the world, with an estimated 2.5 billion people being at risk. Detection of dengue virus infections has great importance for the clinical management of patients, surveillance, and clinical trial assessments. Traditionally, blood samples are collected in serum separator tubes, processed for serum, and then taken to the laboratory for analysis. The use of whole blood has the potential advantages of requiring less blood, providing quicker results, and perhaps providing better sensitivity during the acute phase of the disease. We compared the results obtained by reverse transcriptase PCR (RT-PCR) with blood drawn into tubes containing EDTA and those obtained by RT-PCR with blood samples in serum separator tubes from 108 individuals clinically suspected of being infected with dengue virus. We determined that the extraction of RNA from whole blood followed by RT-PCR resulted in a higher detection rate than the use of serum or plasma. Using a selection of these samples, we also found that our ability to detect virus by direct C6/36 cell culture and mosquito inoculation was enhanced by using whole blood but not to the same extent as that seen by the use of RT-PCR. C1 Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand. Queen Sirikit Natl Inst Child Hlth, Bangkok 10400, Thailand. RP Jarman, RG (reprint author), USAMC, AFRIMS, Dept Virol, APO, AP 96546 USA. EM Richard.Jarman@afrims.org NR 23 TC 40 Z9 41 U1 1 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 2007 VL 45 IS 8 BP 2480 EP 2485 DI 10.1128/JCM.00305-07 PG 6 WC Microbiology SC Microbiology GA 200WK UT WOS:000248793300020 PM 17522268 ER PT J AU Han, ET Watanabe, R Sattabongkot, J Khuntirat, B Sirichaisinthop, J Iriko, H Jin, L Takeo, S Tsuboi, T AF Han, Eun-Taek Watanabe, Risa Sattabongkot, Jetsumon Khuntirat, Benjawan Sirichaisinthop, Jeeraphat Iriko, Hideyuki Jin, Ling Takeo, Satoru Tsuboi, Takafumi TI Detection of four Plasmodium species by genus- and species-specific loop-mediated isothermal amplification for clinical diagnosis SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID POLYMERASE-CHAIN-REACTION; RIBOSOMAL-RNA GENE; MALARIA PARASITES; INFECTIONS; PCR; FALCIPARUM; HUMANS; TESTS; BLOOD; ASSAY AB Loop-mediated isothermal amplification (LAMP), a novel nucleic acid amplification method, was developed for the clinical detection of four species of human malaria parasites: Plasmodium falciparum, P. vivax, P. malariae, and P. ovate. We evaluated the sensitivity and specificity of LAMP in comparison with the results of microscopic examination and nested PCR. LAMP showed a detection limit (analytical sensitivity) of 10 copies of the target 18S rRNA genes for P. malariae and P. ovate and 100 copies for the genus Plasmodium, P. falciparum, and P. vivax. LAMP detected malaria parasites in 67 of 68 microscopically positive blood samples (sensitivity, 98.5%) and 3 of 53 microscopically negative samples (specificity, 94.3%), in good agreement with the results of nested PCR. The LAMP reactions yielded results within about 26 min, on average, for detection of the genus Plasmodium, 32 min for P. falciparum, 31 min for P. vivax, 35 min for P. malariae, and 36 min for P. ovate. Accordingly, in comparison to the results obtained by microscopy, LAMP had a similar sensitivity and a greater specificity and LAMP yielded results similar to those of nested PCR in a shorter turnaround time. Because it can be performed with a simple technology, i.e., with heat-treated blood as the template, reaction in a water bath, and inspection of the results by the naked eye because of the use of a fluorescent dye, LAMP may provide a simple and reliable test for routine screening for malaria parasites in both clinical laboratories and malaria clinics in areas where malaria is endemic. C1 Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. Ehime Univ, Venture Business Lab, Matsuyama, Ehime 7908577, Japan. Kangwon Natl Univ, Coll Med, Dept Parasitol, Chunchon 200701, South Korea. Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand. Vector Borne Dis Ctr, Pra Budhabat 18120, Saraburi, Thailand. RP Tsuboi, T (reprint author), Ehime Univ, Cell Free Sci & Technol Res Ctr, Matsuyama, Ehime 7908577, Japan. EM tsuboi@ccr.ehime-u.ac.jp NR 30 TC 131 Z9 144 U1 2 U2 21 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 2007 VL 45 IS 8 BP 2521 EP 2528 DI 10.1128/JCM.02117-06 PG 8 WC Microbiology SC Microbiology GA 200WK UT WOS:000248793300026 PM 17567794 ER PT J AU Chang, WN Lipton, JS Tsirikos, AI Miller, F AF Chang, Wei-Ning Lipton, Jill Schuyler Tsirikos, Athanasios I. Miller, Freeman TI Kinesiological surface electromyography in normal children: Range of normal activity and pattern analysis SO JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY LA English DT Article DE dynamic electromyography; gait; normal; pediatric ID GAIT ANALYSIS; EMG PROFILES; ONSET; MOVEMENTS; MUSCLES; WALKING AB To document the range of activity and patterns of normal surface kinesiological electromyography in normal children, 87 children ranging from age 3 to 18 years who were developing normally were evaluated at free walking speed. Analysis was performed on 6307 gait cycles from 11 different muscles with custom software. We devised an algorithm to do a computer-based KEMG curve pattern analysis to sort out curves that did not match the physiologic muscle activity pattern, We also devised a combined preset amplitude and statistics-based criteria to satisfactorily determine the onset/cessation of KEMG activity. The measurements of timing and duration of activity, body height and weight, body mass index, cadence, stride length, and age were obtained for statistical analysis. From the pattern recognition, the medial and lateral hamstrings, gluteus maximus and medius, and gastrocnemius muscles had the highest percentage of clinically relevant curves. In most muscle groups, The KEMG curves had an average background activity of about 11-15% of maximum amplitude. The surface KEMG curves from normal subjects have 12.7% cycles that did not match their physiologic activity pattern. The timing and duration of KEMG activity was poorly or only fairly correlated with age, body height, body weight, and body mass index. The ensemble average of the linear envelope KEMG curves of each muscle could be applied as a normal database in a clinical gait analysis laboratory focusing on pediatric patients. (c) 2006 Elsevier Ltd. All rights reserved. C1 Alfred I duPont Hosp Children, Dept Orthopaed Surg, Nemours Childrens Clin, Wilmington, DE 19899 USA. Alfred I duPont Hosp Children, Dept Orthopaed Surg, Gait Anal Lab, Wilmington, DE 19899 USA. Royal Hosp Sick Children, Scottish Natl Spine Deform Ctr, Edinburgh EH9 1LF, Midlothian, Scotland. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Natl Yang Ming Univ, Sch Med, Dept Surg, Taipei 112, Taiwan. Kaohsiung Vet Gen Hosp, Dept Orthopaed, Kaohsiung, Taiwan. RP Miller, F (reprint author), Alfred I duPont Hosp Children, Dept Orthopaed Surg, Nemours Childrens Clin, 1600 Rockland Rd,POB 269, Wilmington, DE 19899 USA. EM fniiller@nemours.org NR 27 TC 11 Z9 12 U1 2 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1050-6411 J9 J ELECTROMYOGR KINES JI J. Electromyogr. Kinesiol. PD AUG PY 2007 VL 17 IS 4 BP 437 EP 445 DI 10.1016/j.jelekin.2006.02.003 PG 9 WC Neurosciences; Physiology; Rehabilitation; Sport Sciences SC Neurosciences & Neurology; Physiology; Rehabilitation; Sport Sciences GA 186EC UT WOS:000247760900008 PM 16603385 ER PT J AU Johnstone, D Golding, TD Hellmer, R Dinan, JH Carmody, M AF Johnstone, D. Golding, T. D. Hellmer, R. Dinan, J. H. Carmody, M. TI Characterization of HgCdTe diodes on si substrates using temperature-dependent current-voltage measurements and deep level transient Spectroscopy SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-IV Materials CY OCT 10-12, 2006 CL Newport Beach, CA DE mercury cadmium telluride; midwave infrared (MWIR); longwave; infrared (LWIR); deep level transient spectroscopy (DLTS); current-voltage-temperature (IVT); dislocation; bias annealing ID DISLOCATIONS AB Reverse current in diodes can be dominated by generation processes, depending exponentially on temperature according to the rate-limiting step in the generation process. In this report, the current-voltage-temperature (IVT) relationship is analyzed for several midwave infrared and long-wave infrared (MWIR x = 0.295, LWIR x = 0.233) Hg1-xCdxTe (MCT) diodes. The energy varied from diode to diode. At high reverse biases, the energy tends toward the band gap energy. Close to zero bias, the energy ranged from 0.06 to 0.1 eV. Deep level transient spectroscopy (DLTS) showed a broad peak centered at 55-80 K for the MWIR MCT. Comparison of the DLTS spectrum to a simulation based on the energy and capture cross section from a rate window analysis shows that the peak is a band of traps. The capacitance transient amplitude increased as the filling pulse increased from 1 mu s to 0.1 s, consistent with capture at a dislocation. A shift to lower temperatures for the peak was also observed when the diodes are cooled under forward bias. The shift is reversible, indicating that the traps consist at least partially of a bistable defect. C1 Semetrol, Chesterfield, VA 23838 USA. Amethyst Res, Ardmore, OK USA. US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA. Rockwell Sci Co, Camarillo, CA 93012 USA. RP Johnstone, D (reprint author), Semetrol, Chesterfield, VA 23838 USA. EM djohnstone@semetrol.com NR 12 TC 1 Z9 3 U1 0 U2 14 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2007 VL 36 IS 8 BP 832 EP 836 DI 10.1007/s11664-007-0104-x PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 207MK UT WOS:000249255000004 ER PT J AU Jaime-Vasquez, M Martinka, M Jacobs, RN Benson, JD AF Jaime-Vasquez, M. Martinka, M. Jacobs, R. N. Benson, J. D. TI Nucleation of ZnTe on the As-terminated Si(112) surface SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-IV Materials CY OCT 10-12, 2006 CL Newport Beach, CA DE ZnTe/Si (112); ion scattering spectroscopy (ISS); x-ray photoelectron spectroscopy (YPS); nucleation; reflection-high energy electron diffraction (RHEED) ID MOLECULAR-BEAM EPITAXY; ELECTRON-SPECTROSCOPY; MISORIENTED SI(001); 112 SI; CDTE; HETEROEPITAXY; SUBSTRATE; ENERGY; LAYERS; TE AB We employ a suite of surface analysis techniques that probe the outermost ZnTe/As-Si(112) surface to generate an understanding of the initial stages of the heteroepitaxial HgCdTe/CdTe/ZnTe/As-Si(112) layer formation. Ion scattering spectroscopy (ISS), reflection-high energy electron diffraction (RHEED), along with nondestructive depth profiles by angle-resolved x-ray photoelectron spectroscopy (XPS) are successfully applied to clarify and support the nucleation stages of ZnTe formation on the As-terminated Si(112) substrate. Data indicate a slow growth of the first ZnTe layer. In addition, no evidence of thick ZnTe island formation exists. The current ZnTe formation process generates full coverage on the Si(112) surface after six to nine MBE cycles. In order to fully understand the details of the ZnTe nucleation process on the Si(112) substrate, we present an inelastic background analysis with the Tougaard method to study surface morphology. C1 US Army Res Dev & Engn Command RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. RP Jaime-Vasquez, M (reprint author), US Army Res Dev & Engn Command RDECOM, CERDEC, NVESD, Ft Belvoir, VA 22060 USA. EM marvin.jaime@nvl.army.mil NR 19 TC 8 Z9 8 U1 2 U2 6 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2007 VL 36 IS 8 BP 905 EP 909 DI 10.1007/s11664-007-0128-2 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 207MK UT WOS:000249255000017 ER PT J AU Benson, JD Almeida, LA Carmody, MW Edwall, DD Markunas, JK Jacobs, RN Martinka, M Lee, U AF Benson, J. D. Almeida, L. A. Carmody, M. W. Edwall, D. D. Markunas, J. K. Jacobs, R. N. Martinka, M. Lee, U. TI Surface structure of molecular beam epitaxy (211)B HgCdTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-IV Materials CY OCT 10-12, 2006 CL Newport Beach, CA DE hgCdTe; CdTe/Si; molecular beam epitaxy; atomic force microscopy; nano-ripple; nano-wire; cross-hatch ID CROSS-HATCH; STRAIN RELAXATION; DEFECT FORMATION; MORPHOLOGY; NANOSTRUCTURES; GROWTH; FILMS; EPILAYERS; MBE AB The as-grown molecular beam epitaxy (MBE) (211)B HgCdTe surface has variable surface topography, which is primarily dependent on substrate temperature and substrate/epilayer mismatch. Nano-ripple formation and cross-hatch patterning are the predominant structural features observed. Nano-ripples preferentially form parallel to the [111] and are from 0 angstrom to 100 angstrom in height with a wavelength between 0.1 mu m and 0.8 mu m. Cross-hatch patterns result from slip dislocations in the three {111} planes intersecting the (211) growth surface. The cross-hatch step height is 4 +/- angstrom (limited data set). This indicates that only a bi-layer slip (Hg/Cd + Te) in the {111} slip plane occurs. For the deposition of MBE (211)B HgCdTe/CdTe/Si, the reorientation of multiple nano-ripples coalesced into "packets" forms cross-hatch patterns. The as-grown MBE (211)B CdTe/Si surface is highly variable but displays nanoripples and no cross-hatch pattern. Three types of defects were observed by atomic force microscopy (AFM): needle, void/hillock, and voids. C1 US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. Teledyne Imaging Sensors, Camarillo, CA USA. US Army Res Lab, Adelphi, MD USA. RP Benson, JD (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA USA. EM dbenson@nvl.army.mil NR 23 TC 9 Z9 10 U1 0 U2 4 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2007 VL 36 IS 8 BP 949 EP 957 DI 10.1007/s11664-007-0143-3 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 207MK UT WOS:000249255000024 ER PT J AU Stoltz, AJ Varesi, JB Benson, JD AF Stoltz, A. J. Varesi, J. B. Benson, J. D. TI Comparing ICP and ECR etching of HgCdTe, CdZnTe, and CdTe SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-IV Materials CY OCT 10-12, 2006 CL Newport Beach, CA DE inductively coupled plasma (ICP); electron cyclotron resonance (ECR); mercury cadmium telluride (HgCdTe); cadmium telluride (CdTe); plasma ID CYCLOTRON-RESONANCE PLASMAS; WAVELENGTH; HG1-XCDXTE; CH4/H-2/AR; DETECTORS; SURFACE; ARRAYS AB The surface roughness of inductively coupled plasma (ICP)-etched CdTe is greater than that of electron cyclotron resonance (ECR)-etched CdTe. This greater roughness is undesirable for further processing of the material. Lower-frequency plasma excitation from the ICP is more efficient at cracking hydrogen than the high-frequency plasma excitation of ECR. In binary semiconductors it is important to balance removal of both constituents. Bombardment controls the removal of the metal constituent while hydrogen removes the tellurium. Research performed with ECR plasma processing on HgCdTe shows that reducing the pressure can greatly reduce hydrogen ionization. Applying this to ICP it can be shown that reduced pressure greatly improves the morphology of CdTe. This balanced etching also greatly improves etch rate and selectivity of HgCdTe. C1 USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. RP Stoltz, AJ (reprint author), USA, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA USA. EM andrew.stoltz@nvl.army.mil NR 14 TC 7 Z9 7 U1 1 U2 5 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2007 VL 36 IS 8 BP 1007 EP 1012 DI 10.1007/s11664-007-0163-z PG 6 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 207MK UT WOS:000249255000032 ER PT J AU Carmody, M Edwall, D Ellsworth, J Arias, J Groenert, M Jacobs, R Almeida, LA Dinan, JH Chen, Y Brill, G Dhar, NK AF Carmody, M. Edwall, D. Ellsworth, J. Arias, J. Groenert, M. Jacobs, R. Almeida, L. A. Dinan, J. H. Chen, Y. Brill, G. Dhar, N. K. TI Role of dislocation scattering on the electron mobility of n-type long wave length infrared HgCdTe on silicon SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT US Workshop on the Physics and Chemistry of II-IV Materials CY OCT 10-12, 2006 CL Newport Beach, CA DE HgCdTe; dislocations; mobility; MBE ID HG1-XCDXTE; GAN; EPITAXY AB It has been reported that the basic electrical properties of n-type long wave length infrared (LWIR) HgCdTe grown on silicon, including the majority carrier mobility (mu e) and minority carrier lifetime (E), are qualitatively comparable to those reported for LWIR HgCdTe grown on bulk CdZnTe by molecular beam epitaxy (MBE). Detailed measurements of the majority carrier mobility have revealed important differences between the values measured for HgCdTe grown on bulk CdZnTe and those measured for HgCdTe grown on buffered silicon substrates. The mobility of LWIR HgCdTe grown on buffered silicon by MBE is reported over a large temperature range and is analyzed in terms of standard electron scattering mechanisms. The role of dislocation scattering is addressed for high dislocation density HgCdTe grown on lattice-mismatched silicon. Differences between the low temperature mobility data of HgCdTe grown on bulk CdZnTe and HgCdTe grown on silicon are partially explained in terms of the dislocation scattering contribution to the total mobility. C1 Teledyne Imaging Sensors, Camarillo, CA 93012 USA. USA, RDECOM CERDEC NVESD, Ft Belvoir, VA USA. USA, Res Lab, Adelphi, MD USA. RP Carmody, M (reprint author), Teledyne Imaging Sensors, 5212 Verdugo Way, Camarillo, CA 93012 USA. EM mcarmody@teledyne.com RI Brill, Gregory/G-4877-2013 NR 19 TC 13 Z9 14 U1 0 U2 4 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD AUG PY 2007 VL 36 IS 8 BP 1098 EP 1105 DI 10.1007/s11664-007-0182-9 PG 8 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA 207MK UT WOS:000249255000044 ER PT J AU Vahey, MT Ockenhouse, CF Wang, ZN Yalley-Ogunro, J Greenhouse, J Nau, ME Lewis, MG AF Vahey, Maryanne T. Ockenhouse, Christian F. Wang, Zhining Yalley-Ogunro, Jake Greenhouse, Jack Nau, Martin E. Lewis, Mark G. TI Impact of antiretroviral treatment on gene expression in peripheral blood mononuclear cells from SIVmac251-infected macaques SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; INFECTED RHESUS-MONKEYS; T-LYMPHOCYTE RESPONSES; CYNOMOLGUS MACAQUES; DISEASE PROGRESSION; VIRAL REPLICATION; IMMUNE-RESPONSE; CD8(+); THERAPY; CD4(+) AB Background. A survey of gene expression in peripheral blood mononuclear cells from cynomolgus macaques infected with SIVmac251 was conducted to ascertain the impact of viral infection and successful antiretroviral (ARV) intervention on gene transcription at peak seroconversion, viral set point, and after treatment with 9-R 2 phosphonomethoxypropyl adenine and beta-2'3' dideoxy-3'-thia-5 fluorocytidine. Methods. Robust multichip average- normalized data sets generated on Affymetrix GeneChips were analyzed using Significance Analysis of Microarrays (SAM), to determine differential gene expression. Unsupervised learning algorithms and gene-ontology tools were used to elucidate hierarchical relationships and to define the function of significantly enriched biological categories of differentially regulated genes. Gene networks associated with immune response and inflammation impacted by ARV treatment were derived by use of Pathway Architect software. Results. Viral infection results in down-regulation of gene expression, which is greatest by the viral set point. Of the 3647 genes down-regulated at the viral set point, 1033 were up-regulated as the result of successful ARV treatment. There is significant overlap in the identity of these genes. Conclusions. Intervention with successful ARV treatment in macaques infected with SIVmac251 results in the partial reversal of the down-regulated gene expression characteristic of early viral infection. C1 Walter Reed Army Inst Res, Div Retrovirol, Washington, DC 20307 USA. Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Washington, DC 20307 USA. Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA. Bioqual Inc, Rockville, MD USA. RP Vahey, MT (reprint author), US Mil Acad, HIV Res Program, Div Retrovirol, 1600 E Gude Dr, Rockville, MD 20850 USA. EM mvahey@hivresearch.org FU NIAID NIH HHS [R01-AI050510] NR 44 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2007 VL 196 IS 3 BP 384 EP 393 DI 10.1086/519388 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 186UH UT WOS:000247803300009 PM 17597453 ER PT J AU Reed, DS Lackemeyer, MG Garza, NL Norris, S Gamble, S Sullivan, LJ Lind, CM Raymond, JL AF Reed, Douglas S. Lackemeyer, Matthew G. Garza, Nicole L. Norris, Sarah Gamble, Scott Sullivan, Lawrence J. Lind, Cathleen M. Raymond, Jo Lynne TI Severe encephalitis in cynomolgus macaques exposed to aerosolized eastern equine encephalitis virus SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID RHESUS-MONKEYS; ENCEPHALOMYELITIS; INFECTION AB Cynomolgus macaques exposed to an aerosol containing a virulent strain of eastern equine encephalitis (EEE) virus developed neurological signs indicating encephalitis that corresponded with the onset of fever and an elevated heart rate. Viremia was either transient or undetectable even in animals that succumbed to the illness. The onset of illness was dose dependent, but once a febrile response was observed, macaques were moribund within 36 h. Simultaneously, a prominent leukocytosis was seen; 1 day before being moribund, macaques had a white blood cell count 120,000 cells/mL. The leukocytes were predominantly granulocytes. Increases in serum levels of blood urea nitrogen, sodium, and alkaline phosphatase were also seen. The rapid onset and severity of neurological signs mirror what has been reported for human cases of disease caused by EEE. C1 USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Res Support, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. RP Reed, DS (reprint author), USA, Med Res Inst Infect Dis, Ctr Aerobiol Sci, 1425 Porter St, Ft Detrick, MD 21702 USA. EM doug.reed@det.amedd.army.mil OI Gamble, Christopher/0000-0002-2094-205X; Reed, Douglas/0000-0003-0076-9023 NR 22 TC 34 Z9 35 U1 1 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2007 VL 196 IS 3 BP 441 EP 450 DI 10.1086/519391 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 186UH UT WOS:000247803300015 PM 17597459 ER PT J AU O'Neil, MT Korsinczky, MLJ Gresty, KJ Auliff, A Cheng, Q AF O'Neil, Michael T. Korsinczky, Michael L. J. Gresty, Karryn J. Auliff, Alyson Cheng, Qin TI A novel Plasmodium falciparum expression system for assessing antifolate resistance caused by mutant P-vivax dihydrofolate reductase-thymidylate synthase SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT Conference on Vivax Malaria Research, 2005 and Beyond CY DEC 09-10, 2005 CL Washington, DC ID SPECIES MALARIA INFECTIONS; SULFADOXINE-PYRIMETHAMINE; MUTATIONS; PARASITES; DHFR; THAILAND; GENE; IDENTIFICATION; TRANSFORMATION; CHLOROQUINE AB With the emergence of drug- resistant vivax malaria, in vitro studies are urgently needed to examine resistance mechanisms and for drug development. Currently, Plasmodium vivax culturing is inadequate for addressing these needs; therefore, surrogate biological systems have been developed. Although these systems are informative, they do not address Plasmodium species-specific mechanisms, such as drug delivery through erythrocytes and parasite membranes. Here, we demonstrate that P. falciparum is an excellent biological system for expression of P. vivax dhfr-ts alleles to assess dihydrofolate reductase (DHFR)-thymidylate synthase interactions with antifolates. Our results show that the P. vivax dhfr-ts quadruple-mutant allele AMRU1, expressed in P. falciparum, provides significant protection against pyrimethamine, cycloguanil, and clocicguanil. Moreover, the PvDHFR quadruple mutant confers greater resistance to cycloguanil, clociguanil, and WR99210 than the PfDHFR quadruple mutant. Modeling of both P. vivax and P. falciparum DHFR quadruple mutants suggests that mutations unique to P. vivax DHFR are responsible for differences seen in parasite susceptibility to antifolates. C1 Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia. Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD USA. RP O'Neil, MT (reprint author), Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia. EM michael.t.oneil@us.army.mil NR 38 TC 9 Z9 10 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG 1 PY 2007 VL 196 IS 3 BP 467 EP 474 DI 10.1086/519286 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 186UH UT WOS:000247803300018 PM 17597462 ER PT J AU Gardner, CL Burke, CW Aguilar, PV Wang, E Glass, PJ Parker, MD Weaver, SC Klimstra, WB Ryman, KD AF Gardner, C. L. Burke, C. W. Aguilar, P. V. Wang, E. Glass, P. J. Parker, M. D. Weaver, S. C. Klimstra, W. B. Ryman, K. D. TI Evasion of type IIFN induction as a mechanism of eastern equine encephalitis virus virulence SO JOURNAL OF INTERFERON AND CYTOKINE RESEARCH LA English DT Meeting Abstract C1 Louisiana State Univ, Hlth Sci Ctr, Shreveport, LA 71105 USA. Univ Texas, Med Branch, Galveston, TX 77550 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21701 USA. RI Glass, Pamela/G-1170-2011; Weaver, Scott/D-6490-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1079-9907 J9 J INTERF CYTOK RES JI J. Interferon Cytokine Res. PD AUG PY 2007 VL 27 IS 8 BP 713 EP 714 PG 2 WC Biochemistry & Molecular Biology; Cell Biology; Immunology SC Biochemistry & Molecular Biology; Cell Biology; Immunology GA 206UN UT WOS:000249208500091 ER PT J AU Sliney, DH Marshall, WJ Brumage, EC AF Sliney, David H. Marshall, Wesley J. Brumage, E. Christopher TI Rationale for laser classification measurement conditions SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser safety; laser hazard classification ID INTERNATIONAL-COMMISSION; OPTICAL RADIATION; EXPOSURE; SYSTEMS; SAFETY; GUIDELINES; LIMITS; EYE AB The basic concept of laser hazard classification with four fundamental risk groups and several subclasses is well understood by most laser users. However, many readers of laser safety standards are frequently puzzled by the rigid measurement conditions applied for hazard classification, even if this is normally a task performed by the laser manufacturer and not by a laser user or a Laser Safety Officer. The historical rationale for the measurement conditions is provided and it is emphasized that the aim of each measurement is to simulate a wide range of ocular exposure conditions that would be reasonably foreseeable worst-case viewing conditions during the use of the laser product. Measurements, if needed to compare human exposures with the maximum permissible exposure limits, emphasize actual exposure conditions and generally do not match the measurement used for hazard classification. (c) 2007 Laser Institute of America. C1 USA, Ctr Hlth Promot & Prevent Med, Laser Opt Radiat Program, Aberdeen Proving Ground, MD 21010 USA. RP Sliney, DH (reprint author), USA, Ctr Hlth Promot & Prevent Med, Laser Opt Radiat Program, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21010 USA. EM david.sliney@att.net NR 35 TC 0 Z9 0 U1 1 U2 5 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD AUG PY 2007 VL 19 IS 3 BP 197 EP 206 DI 10.2351/1.2764026 PG 10 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 208RK UT WOS:000249336700012 ER PT J AU Youn, BD Choi, KK Du, L Gorsich, D AF Youn, Byeng D. Choi, Kyung K. Du, Liu Gorsich, David TI Integration of possibility-based optimization and robust design for epistemic uncertainty SO JOURNAL OF MECHANICAL DESIGN LA English DT Article; Proceedings Paper CT 6th World Congress of Structural and Multidisciplinary Optimization CY JUN 13, 2005 CL Rio de Janeiro, BRAZIL DE robust design; possibility; epistemic uncertainty; fuzzy; membership function ID PROBABILITY AB In practical engineering applications, there exist two different types of uncertainties: aleatory and epistemic uncertainties. This study attempts to develop a robust design optimization with epistemic uncertainty. For epistemic uncertainties, a possibility-based design optimization improves the failure rate, while a robust design optimization minimizes the product quality loss. In general, product quality loss is described using the first two statistical moments for aleatory uncertainty: mean and standard deviation. However there is no metric for product quality loss defined when having epistemic uncertainty. This paper first proposes a new metric for product quality loss with epistemic uncertainty and then a possibility-based robust design optimization. For numerical efficiency and stability, an enriched performance measure approach is employed for possibility-based robust design optimization, and the maximal possibility search is used for a possibility analysis. Three different types of robust objectives are considered for possibility-based robust design optimization: smaller-the better type (S-Type), larger-the-better type (L-Type), and nominal-the-better type (N-Type). Examples are used to demonstrate the effectiveness of possibility-based robust design optimization using the proposed metric for product quality loss with epistemic uncertainty. C1 Michigan Technol Univ, Dept Mech Engn & Engn Mech, Houghton, MI 49931 USA. Univ Iowa, Dept Mech & Ind Engn, Coll Engn, Iowa City, IA 52242 USA. USA, Natl Automot Ctr, AMSTA TR N, MS 263, Warren, MI 48397 USA. RP Youn, BD (reprint author), Michigan Technol Univ, Dept Mech Engn & Engn Mech, Houghton, MI 49931 USA. EM bdyoun@mtu.edu; kkchoi@ccad.uiowa.edu; liudu@ccad.uiowa.edu; gorsichd@tacom.army.mil RI Youn, Byeng/G-2091-2010; Choi, Kyung/B-1512-2008 OI Youn, Byeng/0000-0003-0135-3660; Choi, Kyung/0000-0003-2384-6220 NR 22 TC 30 Z9 32 U1 0 U2 6 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1050-0472 J9 J MECH DESIGN JI J. Mech. Des. PD AUG PY 2007 VL 129 IS 8 BP 876 EP 882 DI 10.1115/1.2717232 PG 7 WC Engineering, Mechanical SC Engineering GA 195NY UT WOS:000248420100011 ER PT J AU Linkov, I Satterstrom, FK Steevens, J Ferguson, E Pleus, RC AF Linkov, Igor Satterstrom, F. Kyle Steevens, Jeffery Ferguson, Elizabeth Pleus, Richard C. TI Multi-criteria decision analysis and environmental risk assessment for nanomaterials SO JOURNAL OF NANOPARTICLE RESEARCH LA English DT Article DE decision analysis; nanotechnology; prioritization; weight of evidence; risk assessment; science and technology governance ID MANAGEMENT AB Nanotechnology is a broad and complex discipline that holds great promise for innovations that can benefit mankind. Yet, one must not overlook the wide array of factors involved in managing nanomaterial development, ranging from the technical specifications of the material to possible adverse effects in humans. Other opportunities to evaluate benefits and risks are inherent in environmental health and safety (EHS) issues related to nanotechnology. However, there is currently no structured approach for making justifiable and transparent decisions with explicit trade-offs between the many factors that need to be taken into account. While many possible decision-making approaches exist, we believe that multi-criteria decision analysis (MCDA) is a powerful and scientifically sound decision analytical framework for nanomaterial risk assessment and management. This paper combines state-of-the-art research in MCDA methods applicable to nanotechnology with a hypothetical case study for nanomaterial management. The example shows how MCDA application can balance societal benefits against unintended side effects and risks, and how it can also bring together multiple lines of evidence to estimate the likely toxicity and risk of nanomaterials given limited information on physical and chemical properties. The essential contribution of MCDA is to link this performance information with decision criteria and weightings elicited from scientists and managers, allowing visualization and quantification of the trade-offs involved in the decision-making process. C1 Intertox Inc, Brookline, MA 02446 USA. Intertox Inc, Seattle, WA 98121 USA. USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Linkov, I (reprint author), Intertox Inc, 83 Winchester St,Suite 1, Brookline, MA 02446 USA. EM ilinkov@intertox.com NR 24 TC 85 Z9 87 U1 0 U2 31 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1388-0764 EI 1572-896X J9 J NANOPART RES JI J. Nanopart. Res. PD AUG PY 2007 VL 9 IS 4 BP 543 EP 554 DI 10.1007/s11051-007-9211-0 PG 12 WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 171SU UT WOS:000246756500002 ER PT J AU Shanti, RM Li, WJ Nesti, LJ Wang, X Tuan, RS AF Shanti, Rabie M. Li, Wan-Ju Nesti, Leon J. Wang, Xibin Tuan, Rocky S. TI Adult mesenchymal stem cells: Biological properties, characteristics, and applications in maxillofacial surgery SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID MARROW STROMAL CELLS; HUMAN BONE-MARROW; HUMAN ADIPOSE-TISSUE; HUMAN TRABECULAR BONE; VIVO GENE-THERAPY; IN-VIVO; MORPHOGENETIC PROTEINS; PROGENITOR CELLS; MANDIBULAR CONDYLE; SKELETAL-MUSCLE C1 NIAMSD, NIH, Cartilage Biol & Orthopaed Branch, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. Natl Inst Hlth Res Scholars Program, Howard Hughes Med Inst, Bethesda, MD USA. Harvard Univ, Sch Dent Med, Boston, MA 02115 USA. Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Tuan, RS (reprint author), NIAMSD, NIH, Cartilage Biol & Orthopaed Branch, Dept Hlth & Human Serv, Hlth Bldg 50,Room 1503,MSC 8022, Bethesda, MD 20892 USA. EM tuanr@mail.nih.gov RI Li, Wan-Ju/A-7002-2008 NR 94 TC 31 Z9 37 U1 0 U2 8 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD AUG PY 2007 VL 65 IS 8 BP 1640 EP 1647 DI 10.1016/j.joms.2007.04.008 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 199OV UT WOS:000248706000031 PM 17656295 ER PT J AU Teyhen, DS AF Teyhen, Deydre S. TI Rehabilitative ultrasound imaging: The roadmap ahead SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material ID LOW-BACK-PAIN; ABDOMINAL-MUSCLES; DRAWING-IN C1 USA Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX USA. Walter Reed Army Med Ctr, Spine Res Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Def Spinal Cord & Column Injury Ctr, Washington, DC 20307 USA. RP Teyhen, DS (reprint author), USA Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX USA. NR 24 TC 13 Z9 13 U1 0 U2 4 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2007 VL 37 IS 8 BP 431 EP 433 DI 10.2519/jospt.2007/0107 PG 3 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 198SL UT WOS:000248647700001 PM 17877279 ER PT J AU Whittaker, JL Teyhen, DS Elliott, JM Cook, K Langevin, HM Dahl, HH Stokes, M AF Whittaker, Jackie L. Teyhen, Deydre S. Elliott, James M. Cook, Katy Langevin, Helene M. Dahl, Haldis H. Stokes, Maria TI Rehabilitative ultrasound imaging: Understanding the technology and its applications SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Review DE elastography; magnetic resonance imaging; rehabilitation; sonography ID LOW-BACK-PAIN; LUMBAR MULTIFIDUS MUSCLE; REAL-TIME ULTRASOUND; M-MODE ULTRASOUND; HEALTHY CONTROL SUBJECTS; CROSS-SECTIONAL AREA; PELVIC GIRDLE PAIN; TRANSVERSUS ABDOMINIS; DIAPHRAGMATIC MOTION; MOTOR CONTROL AB The use of ultrasound imaging by physical therapists is growing in popularity. This commentary has 2 aims. The first is to introduce the concept of rehabilitative ultrasound imaging (RUSI), provide a definition of the scope of this emerging tool in regard to the physical therapy profession, and describe how this relates to the larger field of medical ultrasound imaging, The second aim is to provide an overview of basic ultra sound imaging and instrumentation principles, including an understanding of the various modes and applications of the technology with respect to neuromusculoskeletal rehabilitation and in relation to other common imaging modalities. C1 Whittaker Physiotherapy Consulting, White Rock, BC V4A 1N2, Canada. Univ Southampton, Sch Hlth Profess & Rehabil Sci, Southampton, Hants, England. US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. Ctr Phys Therapy Res, Ft Sam Houston, TX USA. Walter Reed Army Med Ctr, Spine Res Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Def Spinal Cord & Column Injury Ctr, Washington, DC 20307 USA. Regis Univ, Dept Phys Therapy, Rueckert Hartman Sch Hlth Profess, Denver, CO USA. Univ Queensland, Div Physiotherapy, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia. Univ Queensland, Ctr Magnet Resonance, Brisbane, Qld, Australia. St George Hosp, Fetal Med Unit, London, England. Univ Vermont, Dept Neurol Orthopaed & Rehabil, Burlington, VT USA. Univ Trondheim Hosp, Dept Neurol, St Olavs Hosp, Trondheim, Norway. Norwegian Univ Sci & Technol, Dept Neurosci, Fac Med, N-7034 Trondheim, Norway. Univ Southampton, Sch Hlth Profess & Rehabil Ssci, Southampton, Hants, England. RP Whittaker, JL (reprint author), Whittaker Physiotherapy Consulting, 101,12761-16th Ave, White Rock, BC V4A 1N2, Canada. EM J.L.Whittaker@soton.ac.uk RI Stokes, Maria/G-2288-2011; OI Stokes, Maria/0000-0002-4204-0890 NR 144 TC 72 Z9 78 U1 1 U2 16 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2007 VL 37 IS 8 BP 434 EP 449 DI 10.2519/jospt.2007.2350 PG 16 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 198SL UT WOS:000248647700002 PM 17877280 ER PT J AU Teyhen, DS Gill, NW Whittaker, JL Henry, SM Hides, JA Hodges, P AF Teyhen, Deydre S. Gill, Norman W. Whittaker, Jackie L. Henry, Sharon M. Hides, Julie A. Hodges, Paul TI Rehabilitative ultrasound imaging of the abdominal muscles SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Review DE morphometry; obliquus internus abdominis; rectus abdominis; sonography; transversus abdominis ID LOW-BACK-PAIN; RANDOMIZED CONTROLLED-TRIAL; POSTERIOR PELVIC PAIN; M-MODE ULTRASOUND; BODY-MASS INDEX; LEG RAISE TEST; TRANSVERSUS-ABDOMINIS; MULTIFIDUS MUSCLE; INTRAABDOMINAL PRESSURE; LUMBAR SPINE AB Rehabilitative ultrasound imaging (RUSI) of the abdominal muscles is increasingly being used in the management of conditions involving musculoskeletal dysfunctions associated with the abdominal muscles, including certain types of low back and pelvic pain. This commentary provides an overview of current concepts and evidence related to RUSI of the abdominal musculature, including issues addressing the potential role of ultrasound imaging in the assessment and training of these muscles. Both quantitative and qualitative aspects associated with clinical and research applications are considered, as are the possible limitations related to the interpretation of measurements made with RUSI. Research to date has utilized a range of methodological approaches, including different transducer placements and imaging techniques. The pros and cons of the various methods are discussed, and guidelines for future investigations are presented. Potential implications and opportunities for clinical use of RUSI to enhance evidence-based practice are outlined, as are suggestions for future research to further clarify the possible role of RUSI in the evaluation and treatment of abdominal muscular morphology and function. C1 US Army Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA. Ctr Phys Therapy Res, Ft Sam Houston, TX USA. Walter Reed Army Med Ctr, Spine Res Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Def Spinal Cord & Column Injury Ctr, Washington, DC 20307 USA. Whittaker Physiotherapy Consulting, White Rock, BC, Canada. US Army Baylor Univ, Postprofess Doctoral Program Orthopaed & Manual P, Brooke Army Med Ctr, San Antonio, TX USA. Univ Vermont, Dept Rehabil & Movement Sci, Burlington, VT USA. Univ Queensland, Div Physiotherapy, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia. Univ Queensland, Mater Back Stabil Clin, Mater Hlth Serv, Brisbane, Qld, Australia. Univ Queensland, Natl Hlth & Med Res Council Ctr Clin Res Excellen, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia. RP Teyhen, DS (reprint author), 3151 Scott Rd,Room 1303,MCCS-HMT, Ft Sam Houston, TX 78234 USA. EM Deydre.teyhen@us.army.mil RI Hodges, Paul/B-6578-2008; Hides, Julie/F-2141-2011; OI Hodges, Paul/0000-0002-1206-9107; Hides, Julie/0000-0002-1830-8121 FU NICHD NIH HHS [R01 HD040909] NR 124 TC 88 Z9 91 U1 0 U2 14 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2007 VL 37 IS 8 BP 450 EP 466 DI 10.2519/jospt.2007.2558 PG 17 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 198SL UT WOS:000248647700003 PM 17877281 ER PT J AU Raney, NH Teyhen, DS Childs, JD AF Raney, Nicole H. Teyhen, Deydre S. Childs, John D. TI Observed changes in lateral abdominal muscle thickness after spinal manipulation: A case series using rehabilitative ultrasound imaging SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE internal oblique; lumbar stabilization; manual therapy; sonography; transversus abdominis ID LOW-BACK-PAIN; CLINICAL-PREDICTION RULE; TRANSVERSUS-ABDOMINIS; ELECTROMYOGRAPHIC RESPONSES; REFLEX RESPONSES; MECHANICAL FORCE; HEALTHY-SUBJECTS; CONTROLLED-TRIAL; PRIMARY-CARE; DRAWING-IN AB Study design: Case series. Background: A clinical prediction rule (CPR) has been developed and validated that accurately identifies a subgroup of patients with low back pain (LBP) likely to benefit from spinal manipulation; however, the mechanism of spinal manipulation remains unclear The purpose of this case series was to describe changes in lateral abdominal muscle thickness using rehabilitative ultrasound imaging (RUSI) immediately following spinal manipulation in a subgroup of patients positive on the rule. Case descriptions: Data from 9 patients (5 female, 4 male; 18-53 years of age) with a primary complaint of LBP are presented. All patients had symptoms for less than 16 days (range, 3-14 days) and did not have symptoms distal to the knee, satisfying the 2-factor rule for predicting successful outcome from spinal manipulation. The Oswestry Disability Index scores ranged from 8% to 52%. Lateral abdominal muscle thickness was assessed with the patient at-rest and while contracted during an abdominal drawing-in maneuver (ADIM) using RUSI. Measurements were taken before and immediately after spinal manipulation. Patients completed a 15-minute training session of the ADIM prior to assessment, to mitigate the potential for a learning effect to occur. Outcomes: Based on changes that exceeded the threshold for measurement error, 6 of 9 patients demonstrated an improved ability (11.5%-279%) to increase transversus abdominis (TrA) muscle thickness during the ADIM postmanipulation. Additionally, TrA muscle thickness at-rest postmanipulation decreased for 5 patients (11.5%-25.9%), while at-rest internal oblique muscle thickness decreased for 4 patients (6.4%-12.2%). Discussion: This case series describes short-term changes in lateral abdominal muscle thickness post spinal manipulation. Although case series have significant limitations, including the fact that no cause-and-effect claims can be made, the decrease in muscle thickness at rest and the greater increase in muscle thickness during the ADIM postmanipulation observed in some of the patients could suggest an improvement in muscular function, Future research is needed to determine if increased muscle thickness is associated with improvements in pain and disability and to further explore neurophysiologic mechanisms of spinal manipulation. C1 Wilford Hall USAF Med Ctr, San Antonio, TX USA. US Army Baylor Univ, Doctoral Program Phys Therapy, Army Med Dept Ctr, San Antonio, TX USA. US Army Baylor Univ, Doctoral Program Phys Therapy, Army Med Sch, San Antonio, TX USA. Walter Reed Army Med Ctr, Spine Res Ctr, Def Spinal Cord Column & Injury Ctr, Washington, DC 20307 USA. RP Raney, NH (reprint author), 134 Evans Ave, San Antonio, TX 78209 USA. EM nicole.raney@lackland.af.mil NR 52 TC 27 Z9 28 U1 0 U2 2 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2007 VL 37 IS 8 BP 472 EP 479 DI 10.2519/jospt.2007.2523 PG 8 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 198SL UT WOS:000248647700005 PM 17877283 ER PT J AU Whittaker, JL Thompson, JA Teyhen, DS Hodges, P AF Whittaker, Jackie L. Thompson, Judith A. Teyhen, Deydre S. Hodges, Paul TI Rehabilitative ultrasound imaging of pelvic floor muscle function SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE levator ani; sonography; therapeutic exercise; transabdominal ultrasound imaging; transperineal ultrasound imaging ID LOW-BACK-PAIN; STRESS URINARY-INCONTINENCE; LUMBAR MULTIFIDUS MUSCLE; REAL-TIME ULTRASOUND; TRANSVERSUS ABDOMINIS MUSCLE; BLADDER NECK MOBILITY; PERINEAL ULTRASOUND; TRANSPERINEAL ULTRASOUND; PARAVAGINAL DEFECTS; ACTIVATION PATTERNS AB This commentary provides an overview of the current concepts and evidence related to rehabilitative ultrasound imaging of pelvic floor (levator ani) function. As this is an emerging topic, the goal is to provide a basic understanding of ultrasound imaging applications related to levator ani function: the available quantitative and qualitative information, the limitations, as well as how ultrasound imaging can be incorporated as a form of biofeedback during rehabilitation. Furthermore, as the ability to compile and compare existing evidence depends on the degree of similarity in methodology by investigators, this commentary highlights points of consideration and provides guidelines, as well as an agenda, for future investigation. C1 Whittaker Physiotherapy Consulting, White Rock, BC V4A 1N2, Canada. Univ Southampton, Sch Hlth Profess & Rehabil Sci, Southampton, Hants, England. Curtin Univ Technol, Sch Physiotherapy, Perth, WA 6001, Australia. Body Log Physiotherapy, Shenton Pk, WA, Australia. US Army Baylor Univ, Doctoral Program Phys Therapy, San Antonio, TX USA. Ctr Phys Therapy Res, Ft Sam Houston, TX USA. Walter Reed Army Med Ctr, Spine Res Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Def Spinal Cord & Column Injury Ctr, Washington, DC 20307 USA. Univ Queensland, NHMRC, Ctr Clin Res Excellence Spinal Pain Injury & Hlth, Sch Hlth & Rehabil Sci, Brisbane, Qld, Australia. RP Whittaker, JL (reprint author), Whittaker Physiotherapy Consulting, 101,12761 16th Ave, White Rock, BC V4A 1N2, Canada. EM J.L.Whittaker@soton.ac.uk RI Hodges, Paul/B-6578-2008 OI Hodges, Paul/0000-0002-1206-9107 NR 96 TC 19 Z9 20 U1 0 U2 10 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2007 VL 37 IS 8 BP 487 EP 498 DI 10.2519/jospt.2007.2548 PG 12 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 198SL UT WOS:000248647700007 PM 17877285 ER PT J AU Painter, EE Ogle, MD Teyhen, DS AF Painter, Elizabeth E. Ogle, Melissa D. Teyhen, Deydre S. TI Lumbopelvic dysfunction and stress urinary incontinence: A case report applying rehabilitative ultrasound imaging SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE biofeedback; pelvic floor muscles; transversus abdominis; sonography; spine ID LOW-BACK-PAIN; CLINICAL-PREDICTION RULE; MUSCLE ACTIVATION PATTERNS; PELVIC FLOOR MUSCLES; ABDOMINAL-MUSCLES; SPINAL MANIPULATION; VALSALVA MANOUEVRE; WOMEN; CONTRACTION; MOVEMENT AB Study design: Case report. Background: It has been suggested that altered neuromuscular control of the transversus abdominis and pelvic floor muscles may contribute to sacroiliac joint (SIJ) region pain and stress urinary incontinence. There are limited examples describing the evaluation and management of individuals with both SIJ region pain and stress urinary incontinence in the literature. This case report describes a patient with both conditions and details the integration of rehabilitative ultrasound imaging (RUSI) during physical therapy evaluation. Case description: A 35-year-old female soldier presented with a 6-week history of left buttock pain and 4-year history of stress urinary incontinence during activities that involved running, jumping, and fast walking. RUSI was used to supplement the physical assessment process, revealing altered motor control strategies of the transversus abdominis and pelvic floor muscles, and as a form of biofeedback during the rehabilitation process. Outcomes: After completing a rehabilitation program that incorporated principles Of lumbar stabilization and pelvic floor muscle re-education, this patient was able to complete all physical activities in basic combat training without SIJ region pain or urinary leakage. Discussion: This case demonstrates the importance of considering pelvic floor muscle dysfunction and training in a patient with primary complaints of SIJ region pain. It also highlights the potential role of RUSI as both an evaluation and biofeedback tool for the deep abdominal and pelvic floor muscles. C1 Gen Leonard Wood Army Community Hosp, Phys Therapy Clin, Ft Leonard Wood, MO 65473 USA. US Army Baylor Univ, Doctoral Program Phys Therapy, Ctr Phys Therapy Res, San Antonio, TX USA. RP Painter, EE (reprint author), Gen Leonard Wood Army Community Hosp, Phys Therapy Clin, 126 Missouri Ave, Ft Leonard Wood, MO 65473 USA. EM Elizabeth.painter@na.amedd.army.mil NR 39 TC 5 Z9 6 U1 0 U2 6 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 2007 VL 37 IS 8 BP 499 EP 504 DI 10.2519/jospt.2007.2538 PG 6 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 198SL UT WOS:000248647700008 PM 17877286 ER PT J AU Carter, R Cheuvront, SN Sawka, MN AF Carter, Robert, III Cheuvront, Samuel N. Sawka, Michael N. TI A case report of idiosyncratic hyperthermia and review of US army heat stroke hospitalizations SO JOURNAL OF SPORT REHABILITATION LA English DT Article ID HEATSTROKE; ILLNESS AB Objectives: We report our observations on one soldier with abnormal hyperthermia during exercise in the heat compared with prior exercise and following acute local (non-febrile) infection. Also, we report on 994 heat stroke hospitalizations in the U.S. Army. It is known that prior infection is a risk factor for heat illness and some of the 37 heat stroke deaths cited infections (eg, pneumonia, influenza) in the medical records. Results: This case report illustrates complete recovery from abnormal hyperthermia, which occurred in a laboratory setting during mild, low intensity exercise. In a field setting, this case may have resulted in serious heat illness. As with most of the heat stroke cases, rapid medical attention (ie, cooling and rehydration) and the age group (19 to 26) that represents majority of the heatstroke cases in U.S. Army are likely factors that contribute successful treatment of heatstroke in the field environment. Conclusions: We conclude that acute inflammatory response can augment the hyperthermia of exercise and possibly increase heat illness susceptibility. Furthermore, it is important for health care providers of soldiers and athletes to monitor acute local infections due to the potential thermoregulatory consequences during exercise in the heat. C1 CRRSA, Dept Human Factors, F-38240 La Tronche, France. USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. RP Carter, R (reprint author), CRRSA, Dept Human Factors, Ave Lyon, F-38240 La Tronche, France. EM robert.carteriii@us.army.mil NR 12 TC 10 Z9 10 U1 0 U2 3 PU HUMAN KINETICS PUBL INC PI CHAMPAIGN PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA SN 1056-6716 J9 J SPORT REHABIL JI J. Sport Rehabil. PD AUG PY 2007 VL 16 IS 3 BP 238 EP 243 PG 6 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA 198DS UT WOS:000248607800010 PM 17923730 ER PT J AU Summers, V Cord, MT AF Summers, Van Cord, Mary T. TI Intelligibility of speech in noise at high presentation levels: Effects of hearing loss and frequency region SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article; Proceedings Paper CT 149th Meeting of the Acoustical-Society-of-America CY MAY 16-20, 2005 CL Vancouver, CANADA SP Acoust Soc Amer ID IMPAIRED LISTENERS; CHINCHILLA COCHLEA; WORD RECOGNITION; AUDIBILITY; INTENSITY AB These experiments examined how high presentation levels influence speech recognition for high- and low-frequency stimuli in noise. Normally hearing (NH) and hearing-impaired (HI) listeners were tested. In Experiment 1, high- and low-frequency bandwidths yielding 70%-correct word recognition in quiet were determined at levels associated with broadband speech at 75 dB SPL. In Experiment 2, broadband and band-limited sentences (based on passbands measured in Experiment 1) were presented at this level in speech-shaped noise filtered to the same frequency bandwidths as targets. Noise levels were adjusted to produce similar to 30%-correct word recognition. Frequency bandwidths and signal-to-noise ratios supporting criterion performance in Experiment 2 were tested at 75, 87.5, and 100 dB SPL in Experiment 3. Performance tended to decrease as levels increased. For NH listeners, this "rollover" effect was greater for high-frequency and broadband materials than for low-frequency stimuli. For HI listeners, the 75- to 87.5-dB increase improved signal audibility for high-frequency stimuli and rollover was not observed. However, the 87.5- to 100-dB increase produced qualitatively similar results for both groups: scores decreased most for high-frequency stimuli and least for low-frequency materials. Predictions of speech intelligibility by quantitative methods such as the Speech Intelligibility Index may be improved if rollover effects are modeled as frequency dependent. (C) 2007 Acoustical Society of America. C1 Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. RP Summers, V (reprint author), Walter Reed Army Med Ctr, Army Audiol & Speech Ctr, Washington, DC 20307 USA. EM walter.summers@na.amedd.army.mil NR 31 TC 11 Z9 11 U1 0 U2 2 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 2007 VL 122 IS 2 BP 1130 EP 1137 DI 10.1121/1.2751251 PG 8 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 198RB UT WOS:000248644100040 PM 17672659 ER PT J AU Nie, X Chen, WW Sun, X Templeton, DW AF Nie, Xu Chen, Weinong W. Sun, Xin Templeton, D.W. TI Dynamic failure of borosilicate glass under Compression/Shear loading experiments SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article ID SODA-LIME GLASS; SMALL STEEL SPHERES; SILICON-CARBIDE; UNIAXIAL COMPRESSION; STRENGTH; IMPACT; SHEAR; CERAMICS; WAVES; CONFINEMENT AB Dynamic compression/shear experiments on a borosilicate glass at an average strain rate of 250 s(-1) are conducted using a modified version of a split Hopkinson pressure bar. Instead of applying confining pressure, cuboid specimens with the material axis inclining to the loading direction at different angles (0 degrees, 3 degrees, 5 degrees, and 7 degrees) are used to generate higher shear stresses. A highspeed digital camera, synchronized with the loading stress pulse, is used to record the dynamic crack initiation and propagation. Experimental results show that the equivalent stress at failure decreases with increasing shear portion in the stress. Digital images show that the cracks initiate randomly in the right specimen, whereas cracks initiate from the stress-concentrated corners in the inclined specimens. Subsequent crack propagation, despite specimen inclination angles, is along the specimen axis rather than the compressive loading direction. C1 Purdue Univ, AAE Sch, W Lafayette, IN 47907 USA. Purdue Univ, MSE Sch, W Lafayette, IN 47907 USA. Pacific NW Natl Lab, Richland, WA 99352 USA. US Army Tank & Automot Res & Dev, Warren, MI 48397 USA. RP Chen, WW (reprint author), Purdue Univ, AAE Sch, W Lafayette, IN 47907 USA. EM wchen@purdue.edu NR 27 TC 25 Z9 29 U1 0 U2 9 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD AUG PY 2007 VL 90 IS 8 BP 2556 EP 2562 DI 10.1111/j.1551-2916.2007.01819.x PG 7 WC Materials Science, Ceramics SC Materials Science GA 194YL UT WOS:000248379600040 ER PT J AU Connelly, NA Brown, TL Brown, JW AF Connelly, Nancy A. Brown, Tommy L. Brown, Jonathan W. TI Measuring the net economic value of recreational boating as water levels fluctuate SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION LA English DT Article DE contingent valuation; economics; Great Lakes; planning; recreational boating; stage-damage curves; water levels ID MANAGEMENT; IMPACTS AB The purpose of this article was to show how the value of recreational boating can be assessed and how that value can be linked to water levels. Data were gathered via a survey of recreational boaters to determine days boated and willingness-to-pay (net economic value) for boating on Lake Ontario and on the St. Lawrence River in 2002. Depth measurements were taken at marinas and yacht clubs, boat launch ramps, and private docks. Stage-damage curves were used to pinpoint at what water levels and to what extent boaters would be impacted. Boaters recreated an estimated 1.3 million days in 2002 and spent an estimated US$178 million in New York counties bordering Lake Ontario and the St. Lawrence River. The mean net economic value per day per boat (above current expenditures) was $69.36, with an estimated total net economic value of US$90 million. Using Lake Ontario as an example, the stage-damage curves show that the overall negative impact would be small, between 245 and 248 ft. Maintaining water levels within that range for the entire boating season would be ideal for Lake Ontario boaters and associated businesses. C1 Cornell Univ, Dept Nat Resources, Human Dimens Res Unit, Ithaca, NY 14853 USA. USA, Corps Engineers, Buffalo, NY 14207 USA. RP Connelly, NA (reprint author), Cornell Univ, Dept Nat Resources, Human Dimens Res Unit, 126 Fernow Hall, Ithaca, NY 14853 USA. EM nac4@cornell.edu NR 20 TC 2 Z9 2 U1 1 U2 3 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1093-474X J9 J AM WATER RESOUR AS JI J. Am. Water Resour. Assoc. PD AUG PY 2007 VL 43 IS 4 BP 1016 EP 1023 DI 10.1111/j.1752-1688.2007.00083.x PG 8 WC Engineering, Environmental; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA 199FU UT WOS:000248682400017 ER PT J AU Cancio, LC AF Cancio, Leopoldo C. TI Comparison of a new hemostatic agent to current combat hemostatic agents in a swine model of lethal extremity arterial hemorrhage - Editorial comment SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 3 TC 2 Z9 2 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2007 VL 63 IS 2 BP 283 EP 284 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 200AC UT WOS:000248735300006 ER PT J AU Eastridge, BJ Salinas, J McManus, JG Blackburn, L Bugler, EM Cooke, WH Concertino, VA Wade, CE Holcomb, JB AF Eastridge, Brian J. Salinas, Jose McManus, John G. Blackburn, Lome Bugler, Eileen M. Cooke, William H. Concertino, Victor A. Wade, Charles E. Holcomb, John B. TI Hypotension begins at 110 mm Hg: Redefining "Hypotension" with data SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 65th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 28-30, 2006 CL New Orleans, LA SP Amer Assoc Surg Trauma DE hypotension; shock; trauma; base deficit; systolic blood pressure; mortality ID TRAUMA PATIENTS; BLOOD-PRESSURE; BASE DEFICIT; VITAL SIGNS; HEART-RATE; RESUSCITATION; ASSOCIATION; PREDICTORS; HEMORRHAGE; MORTALITY AB Background. Clinicians routinely refer to hypotension as a systolic blood pressure (SBP) <= 90 mm Hg. However, few data exist to support the rigid adherence to this arbitrary cutoff. We hypothesized that the physiologic hypoperfusion and mortality outcomes classically associated with hypotension were manifest at higher SBPs. Methods. A total of 870,634 patient records from the National Trauma Data Bank with emergency department SBP and mortality data were analyzed. Patients (140,898) with severe head injuries, a Glasgow Coma Score <= 8, and base deficit (BD) < 5, or missing data items were excluded from analysis. Admission BD, as a measure of metabolic hypoperfusion, was evaluated in 81,134 patients and mortality was plotted against SBP. Results. Baseline mortality was < 2.5%. However, at 110 mm Hg, the slope of the mortality curve increased such that mortality was 4.8% greater for every 10-mm Hg decrement in SBP. This effect was consistent to a maximum of 26% mortality at a SBP of 60 mm Hg. Hypoperfusion (change in the slope of BD curve) began to increase above baseline of 4.5 at a SBP 118 rum Hg. Conclusion. Taking the BD and mortality measurements together, this analysis shows that a SBP <= 110 mm Hg is a more clinically relevant definition of bypotension and hypoperfusion than is 90 mm Hg. This analysis will also be useful for developing appropriately powered studies of hemorrhagic shock. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Washington, Dept Surg, Seattle, WA 98195 USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 23 TC 127 Z9 129 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD AUG PY 2007 VL 63 IS 2 BP 291 EP 297 DI 10.1097/TA.0b013e31809ed924 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 200AC UT WOS:000248735300010 PM 17693826 ER PT J AU Brailey, K Vasterling, JJ Proctor, SP Constans, JI Friedman, MJ AF Brailey, Kevin Vasterling, Jennifer J. Proctor, Susan P. Constans, Joseph I. Friedman, Matthew J. TI PTSD symptoms, life events, and unit cohesion in US soldiers: Baseline findings from the neurocognition deployment health study SO JOURNAL OF TRAUMATIC STRESS LA English DT Article ID POSTTRAUMATIC-STRESS-DISORDER; WAR-ZONE; MILITARY PERSONNEL; VIETNAM VETERANS; SOCIAL SUPPORT; COMBAT; FEMALE; IRAQ; DISINTEGRATION; PREMILITARY AB Relationships among a modifiable situational factor (unit cohesion), Prior stressful life events, and posttraumatic stress disorder (PTSD) symptoms were assessed in 1,579 U.S. Army soldiers with no history of contemporary war zone deployment. It was predicted that unit cohesion would attenuate the dose-response relationship between past stressor exposures and PTSD symptoms at relatively moderate levels of exposure. Consistent with this hypothesis, regression analysis revealed that life experiences and unit cohesion strongly and independenty predicted PTSD symptoms, and that unit cohesion attenuated the impact of life experiences on PTSD. Some military personnel reported significant predeployment, stress-related symptoms. These symptoms may serve as vulnerabilities that could potentially be activated by subsequent war-zone deployment. Higher predeployment unit cohesion levels appear to ameliorate such symptoms, potentially lessening future vulnerability. C1 VA Boston Healthcare Syst, Psychol Serv 116B, Boston, MA 02130 USA. Tulane Univ, New Orleans, LA 70118 USA. SE Louisiana Vet Hlth Care Syst, New Orleans, LA USA. USA, Environm Med Res Inst, VA Boston HealthCare Syst, Boston, MA USA. Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA. VA Natl Ctr PTSD, White River Jct, VT USA. Dartmouth Coll, Sch Med, Hanover, NH USA. RP Brailey, K (reprint author), VA Boston Healthcare Syst, Psychol Serv 116B, Jamaica Plain Campus 150 s Huntington Ave, Boston, MA 02130 USA. EM Kevin.Brailey@va.gov NR 39 TC 86 Z9 87 U1 3 U2 8 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0894-9867 J9 J TRAUMA STRESS JI J. Trauma Stress PD AUG PY 2007 VL 20 IS 4 BP 495 EP 503 DI 10.1002/its.20234 PG 9 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA 206KX UT WOS:000249183400012 PM 17721953 ER PT J AU Djavani, MM Crasta, OR Zapata, JC Fei, Z Folkerts, O Sobral, B Swindells, M Bryant, J Davis, H Pauza, CD Lukashevich, IS Hammamieh, R Jett, M Salvato, MS AF Djavani, Mahmoud M. Crasta, Oswald. R. Zapata, Juan Carlos Fei, Zhangjun Folkerts, Otto Sobral, Bruno Swindells, Mark Bryant, Joseph Davis, Harry Pauza, C. David Lukashevich, Igor S. Hammamieh, Rasha Jett, Marti Salvato, Maria S. TI Early blood profiles of virus infection in a monkey model for lassa fever SO JOURNAL OF VIROLOGY LA English DT Article ID LYMPHOCYTIC CHORIOMENINGITIS VIRUS; RESPIRATORY SYNCYTIAL VIRUS; NF-KAPPA-B; PLASMACYTOID DENDRITIC CELLS; LETHAL HEMORRHAGIC-FEVER; I INTERFERON RESPONSE; CD4(+) T-LYMPHOCYTES; FINGER-Z-PROTEIN; GENE-EXPRESSION; INFLUENZA-VIRUS AB Acute arenavirus disease in primates, like Lassa hemorrhagic fever in humans, begins with flu-like symptoms and leads to death approximately 2 weeks after infection. Our goal was to identify molecular changes in blood that are related to disease progression. Rhesus macaques (Macaca mulatta) infected intravenously with a lethal dose of lymphocytic choriomeningitis virus (LCMV) provide a model for Lassa virus infection of humans. Blood samples taken before and during the course of infection were used to monitor gene expression changes that paralleled disease onset. Changes in blood showed major disruptions in eicosanoid, immune response, and hormone response pathways. Approximately 12% of host genes alter their expression after LCMV infection, and a subset of these genes can discriminate between virulent and nonvirulent LCMV infection. Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease. C1 Univ Maryland, Inst Biotechnol, Inst Human Virol, Baltimore, MD 21201 USA. Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA. Walter Reed Army Inst Res, Div Pathol, Silver Spring, MD 20910 USA. RP Salvato, MS (reprint author), Univ Maryland, Inst Biotechnol, Inst Human Virol, 725 W Lombard St, Baltimore, MD 21201 USA. EM salvato@umbi.umd.edu FU NIAID NIH HHS [U54 AI057168, AI053619, AI053620, R21 AI053619, R21 AI053620] NR 80 TC 39 Z9 39 U1 1 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD AUG PY 2007 VL 81 IS 15 BP 7960 EP 7973 DI 10.1128/JVI.00536-07 PG 14 WC Virology SC Virology GA 189ZL UT WOS:000248027400014 PM 17522210 ER PT J AU Ramanathan, HN Chung, DH Plane, SJ Sztul, E Chu, YK Guttieri, MC McDowell, M Ali, G Jonsson, CB AF Ramanathan, Harish N. Chung, Dong-Hoon Plane, Steven J. Sztul, Elizabeth Chu, Yong-Kyu Guttieri, Mary C. McDowell, Michael Ali, Georgia Jonsson, Colleen B. TI Dynein-dependent transport of the hantaan virus nucleocapsid protein to the endoplasmic reticulum-golgi intermediate compartment SO JOURNAL OF VIROLOGY LA English DT Article ID MEMBRANE-ASSOCIATED PROTEIN; HANTAVIRUS N-PROTEIN; VIRAL-RNA PANHANDLE; SWINE-FEVER VIRUS; VACCINIA VIRUS; BREFELDIN-A; HEMORRHAGIC-FEVER; TULA-HANTAVIRUS; MEDIATED ENDOCYTOSIS; BETA(3) INTEGRINS AB In contrast to most negative-stranded RNA viruses, hantaviruses and other viruses in the family Bunyaviridae mature intracellularly, deriving the virion envelope from the endoplasmic reticulum (ER) or Golgi compartment. While it is generally accepted that Old World hantaviruses assemble and bud into the Golgi compartment, some studies with New World hantaviruses have raised the possibility of maturation at the plasma membrane as well. Overall, the steps leading to virion assembly remain largely undetermined for hantaviruses. Because hantaviruses do not have matrix proteins, the nucleocapsid protein (N) has been proposed to play a key role in assembly. Herein, we examine the intracellular trafficking and morphogenesis of the prototype Old World hantavirus, Hantaan virus (HTNV). Using confocal microscopy, we show that N colocalized with the ER-Golgi intermediate compartment (ERGIC) in HTNV-infected Vero E6 cells, not with the ER Golgi compartment, or early endosomes. Brefeldin A, which effectively disperses the ER, the ERGIC, and Golgi membranes, redistributed N with the ERGIC, implicating membrane association; however, subcellular fractionation experiments showed the majority of N in particulate fractions. Confocal microscopy revealed that N was juxtaposed to and distributed along microtubules and, over time, became surrounded by vimentin cages. To probe cytoskeletal association further, we probed trafficking of N in cells treated with nocodazole and cytochalasin D, which depolymerize microtubules and actin, respectively. We show that nocodazole, but not cytochalasin D, affected the distribution of N and reduced levels of intracellular viral RNA. These results suggested the involvement of microtubules in trafficking of N, whose movement could occur via molecular motors such as dynein. Overexpression of dynamitin, which is associated with dynein-mediated transport, creates a dominant-negative phenotype blocking transport on microtubules. Overexpression of dynamitin reduced N accumulation in the perinuclear region, which further supports microtubule components in N trafficking. The combined results of these experiments support targeting of N to the ERGIC prior to its movement to the Golgi compartment and the requirement of an intact ERGIC for viral replication and, thus, the possibility of virus factories in this region. C1 So Res Inst, Emerging Infect Dis Res Program, Dept Biochem & Mol Biol, Birmingham, AL 35205 USA. Univ Alabama, Grad Program Biochem & Mol Genet, Birmingham, AL 35294 USA. Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Jonsson, CB (reprint author), So Res Inst, Emerging Infect Dis Res Program, Dept Biochem & Mol Biol, 2000 9th Ave S, Birmingham, AL 35205 USA. EM Jonsson@sri.org RI RAMANATHAN, HARISH/B-1274-2013 OI RAMANATHAN, HARISH/0000-0001-6073-2981 NR 82 TC 37 Z9 40 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD AUG PY 2007 VL 81 IS 16 BP 8634 EP 8647 DI 10.1128/JVI.00418-07 PG 14 WC Virology SC Virology GA 198SZ UT WOS:000248649100027 PM 17537852 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The coldest winter: America and the Korean war SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD AUG PY 2007 VL 132 IS 13 BP 101 EP 101 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 200XZ UT WOS:000248797400257 ER PT J AU Yost, SL Pennington, JC Brannon, JM Hayes, CA AF Yost, Sally L. Pennington, Judith C. Brannon, James M. Hayes, Charolett A. TI Environmental process descriptors for TNT, TNT-related compounds and picric acid in marine sediment slurries SO MARINE POLLUTION BULLETIN LA English DT Article DE TNT; picric acid; kinetics; sorption; marine; explosives ID CRASSOSTREA-VIRGINICA; SALMO-GAIRDNERI; RAINBOW-TROUT; TOXICITY; 2,4,6-TRINITROTOLUENE; EXPLOSIVES; REDUCTION; BINDING; WATER; FATE AB Process descriptors were determined for picric acid, TNT, and the TNT-related compounds 2,4DNT, 2,6DNT, 2ADNT, 4ADNT, 2,4DANT, 2,6DANT, TNB and DNB in marine sediment slurries. Three marine sediments of various physical characteristics (particle size ranging from 15 to >90% fines and total organic carbon ranging from <0. 10 to 3.60%) were kept in suspension with 20 ppt saline water. Concentrations of TNT and its related compounds decreased immediately upon contact with the marine sediment slurries, with aqueous concentrations slowly declining throughout the remaining test period. Sediment-water partition coefficients could not be determined for these compounds since solution phase concentrations were unstable. Kinetic rates and half-lives were influenced by the sediment properties, with the finer grained, higher organic carbon sediment being the most reactive. Aqueous concentrations of picric acid were very stable, demonstrating little partitioning to the sediments. Degradation to picramic acid was minimal, exhibiting concentrations at or just above the detection limit. Published by Elsevier Ltd. C1 USA, Ctr Res Dev & Engn, Environm Lab, Vicksburg, MS 39180 USA. SpecPro Inc, Huntsville, AL 35805 USA. RP Yost, SL (reprint author), USA, Ctr Res Dev & Engn, Environm Lab, 3900 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Sally.L.Yost@erde.usace.army.mil NR 16 TC 13 Z9 15 U1 0 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0025-326X EI 1879-3363 J9 MAR POLLUT BULL JI Mar. Pollut. Bull. PD AUG PY 2007 VL 54 IS 8 BP 1262 EP 1266 DI 10.1016/j.marpolbul.2007.03.019 PG 5 WC Environmental Sciences; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA 206CU UT WOS:000249162300030 PM 17512956 ER PT J AU Sawka, MN Noakes, TD AF Sawka, Michael N. Noakes, Timothy D. TI Does dehydration impair exercise performance? SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Editorial Material ID SKELETAL-MUSCLE RECRUITMENT; INGESTED FLUID VOLUME; PROLONGED EXERCISE; CYCLING PERFORMANCE; WEIGHT CHANGES; ANTICIPATORY REDUCTION; RUNNING PERFORMANCE; ROWING PERFORMANCE; PERCEIVED EXERTION; ENDURANCE CAPACITY C1 USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Sawka, MN (reprint author), USA, Environm Med Res Inst, Natick, MA 01760 USA. RI Noakes, Timothy/E-7253-2011 OI Noakes, Timothy/0000-0001-7244-2375 NR 80 TC 84 Z9 86 U1 6 U2 76 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD AUG PY 2007 VL 39 IS 8 BP 1209 EP 1217 DI 10.1249/mss.0b013e318124a664 PG 9 WC Sport Sciences SC Sport Sciences GA 197UH UT WOS:000248581500001 PM 17762351 ER PT J AU Nindl, BC Barnes, BR Alemany, JA Frykman, PN Shippee, RL Friedl, KE AF Nindl, Bradley C. Barnes, Brian R. Alemany, Joseph A. Frykman, Peter N. Shippee, Ronald L. Friedl, Karl E. TI Physiological consequences of US army ranger training SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE weight loss; physical performance; soldiers; vertical jump; stress hormones ID PROLONGED PHYSICAL STRAIN; PERFORMANCE RESPONSES; SLEEP-DEPRIVATION; ENERGY DEFICIENCY; HEALTHY-MEN; WEIGHT-LOSS; YOUNG MEN; TESTOSTERONE; STRENGTH; SERUM AB Purpose: Soldiers are expected to maintain a high degree of physical readiness as operational demands can severely degrade performance capabilities. This study examined the physiological consequences of U.S. Army Ranger training on strength, power, body composition, and somatotrophic hormones. Methods: In an intensive 8-wk military training course that included an average daily energy deficit of 1000 kcal.d(-1), lower-body power output, maximal lifting strength, body composition, and serum concentrations of several somatotrophic hormones were measured in 50 male soldiers (24.6 +/- 4.4 y; 176.1 +/- 7.8 cm; 78.4 +/- 8.7 kg; 14.7 +/- 4.2% body fat) before and after the course. Results: Vertical jump height (-16%), explosive power output (-21%), maximal lifting strength. (-20%), body mass (-13%), fat-free mass (-6%), and fat mass (-50%) declined (P < 0.05) after the training course. Circulating total testosterone and insulin-like growth factor-1 (IGF-I) experienced significant (P < 0.05) declines, and cortisol was significantly increased. Lower-body power output, but not maximal lifting strength, correlated with changes in fat-free mass. IGF-I and cortisol, but not total testosterone, were correlated with losses of tissue mass. Conclusion: Lower-body power output, estimated from vertical jump height and body mass, is a sensitive and field expedient measure that can be used to assess the influence of caloric deficit on physical performance after 8 wk of U.S. Army Ranger training. With severe weight loss (>= 13% of body mass), IGF-I and cortisol correlate more closely with soft-tissue tissue adaptations than does testosterone. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. EM Bradley.Nindl@NA.AMEDD.Army.Mil OI Friedl, Karl/0000-0002-3134-8427 NR 35 TC 65 Z9 66 U1 0 U2 6 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD AUG PY 2007 VL 39 IS 8 BP 1380 EP 1387 DI 10.1249/mss.0b013e318067e2f7 PG 8 WC Sport Sciences SC Sport Sciences GA 197UH UT WOS:000248581500022 PM 17762372 ER PT J AU Nishiizumi, K Caffee, MW Taylor, S AF Nishiizumi, K. Caffee, M. W. Taylor, S. TI Cosmogenic radionuclides in glass spherules from the South Pole water well in Antarctica SO METEORITICS & PLANETARY SCIENCE LA English DT Meeting Abstract CT 70th Annual Meeting of the Meteoritical-Society CY AUG 13-17, 2007 CL Tucson, AZ SP Meteorit Soc, Univ Arizona Lunar & Planetary Lab, Univ Arizona Dept Geosci, Univ Arizona Coll Sci, Life & Planets Astrobiol Ctr, NSF Arizona AMS Lab, SW Meteorite Ctr, Steward Observ, Lunar & Planetary Inst, Natl Aeronaut & Space Adm, Planetary Sci Inst, Barringer Crater Co, Lockheed Martin, Cameca, New Wave, Planetary Studies Fdn, Thermo Finnigan, Univ Arizona Press, Tucson Visitors & Convent Bur, Univ Arizona Dept Phys C1 Univ Calif Berkeley, Space Sci Lab, Berkeley, CA 94720 USA. Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA. CRREL, Dept Army, Hanover, NH 03755 USA. EM kuni@ssl.berkeley.edu NR 7 TC 1 Z9 1 U1 0 U2 1 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 USA SN 1086-9379 J9 METEORIT PLANET SCI JI Meteorit. Planet. Sci. PD AUG PY 2007 VL 42 SU S BP A118 EP A118 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 200HZ UT WOS:000248755800219 ER PT J AU Warner, CM Warner, CH Breitbach, J Rachal, J Matuszak, T Griegr, TA AF Warner, Carolynn M. Warner, Christopher H. Breitbach, Jill Rachal, James Matuszak, Theresa Griegr, Thomas A. TI Depression in entry-level military personnel SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 158th Annual Meeting of the American-Psychiatric-Association CY MAY 21-26, 2005 CL Atlanta, GA SP Amer Psychiat Assoc ID NATIONAL-COMORBIDITY-SURVEY; UNITED-STATES; SEXUAL-ABUSE; PREVALENCE; CARE; DISORDERS; LIFETIME AB Objective: The goal was to determine the prevalence of, and risk factors for, depression in an entry-level U.S. Army population. Method: A cross-sectional survey of U.S. Army soldiers in advanced individual training was performed by using an anonymous self-report survey including demographic data, history (including abuse and psychiatric treatment), and the Patient Health Questionnaire-9. Results: Soldiers in advanced individual training (n = 1,184) were approached, and 1,090 (91.2%; 955 male soldiers and 135 female soldiers) voluntarily chose to participate. Eleven percent reported a psychiatric history, 26% reported a history of abuse, and 15.9% endorsed moderate or more severe current depressive symptoms (male, 15.0%; female, 22.2%). A history, of psychiatric treatment (odds ratio, 2.08; 95% confidence interval, 1.21-3.59; p = 0.009) and a history of verbal abuse (odds ratio, 4.11; 95% confidence interval, 2.45-6.90; p = 0.000) placed soldiers at higher risk for depression. Conclusions: Our study shows a higher than expected rate of depression in entry-level training soldiers and identifies some risk factors for depression. This indicates an important need for further study, effective screening, preventive counseling, and early intervention. C1 Third Infantry Div, Ft Stewart, GA 31314 USA. Winn Army Community Hosp, Dept Family Practice, Ft Stewart, GA 31314 USA. Offutt AFB, Ehrling Berquist Clin, Dept Psychiat, Offutt AFB, NE 68113 USA. Gen Leonard Wood Army Community Hosp, Dept Psychiat, Ft Leonardwood, MO 65437 USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. 1st Special Warfare Ctr, Ft Bragg, NC 28310 USA. Sch Airborne, Ft Bragg, NC 28310 USA. RP Warner, CH (reprint author), Third Infantry Div, Ft Stewart, GA 31314 USA. NR 18 TC 12 Z9 12 U1 1 U2 2 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2007 VL 172 IS 8 BP 795 EP 799 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 201JW UT WOS:000248828400003 PM 17803068 ER PT J AU Whitehouse, CA Baldwin, C Wasieloski, L Kondig, J Scherer, J AF Whitehouse, Chris A. Baldwin, Carson Wasieloski, Leonard Kondig, John Scherer, John TI Molecular identification of the biowarfare simulant serratia marcescens from a 50-year-old munition buried at Fort Detrick, Maryland SO MILITARY MEDICINE LA English DT Article ID RPOB SEQUENCES; PHYLOGENY; RNA AB Serratia marcescens are Gram-negative bacteria that were often used by the U.S. military and others to track movement of bacteria in the environment. As part of ongoing construction at Fort Detrick, Maryland, what appeared to be a small bomblet was found buried in the ground at the site of an old test grid. A sample of a clear, straw-colored liquid was aseptically removed from the plastic reservoir; the results of routine cultures on standard bacteriological media were negative. DNA was extracted from the sample and found to be 99% identical to S. marcescens. These results demonstrate the ability to identify the contents of a biological munition that had been buried for similar to 50 years. C1 USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. RP Whitehouse, CA (reprint author), USA, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 2007 VL 172 IS 8 BP 860 EP 863 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 201JW UT WOS:000248828400014 PM 17803079 ER PT J AU Fan, W Hamilton, T Webster-Sesay, S Nikolich, MP Lindler, LE AF Fan, Wei Hamilton, Tacita Webster-Sesay, S. Nikolich, Mikeljon P. Lindler, Luther E. TI Multiplex real-time SYBR Green IPCR assay for detection of tetracycline efflux genes of Gram-negative bacteria SO MOLECULAR AND CELLULAR PROBES LA English DT Article DE real-time PCR; tetracycline resistance gene; multiplex ID POLYMERASE-CHAIN-REACTION; RESISTANCE DETERMINANTS; STAPHYLOCOCCUS-AUREUS; RIBOSOMAL PROTECTION; PCR ASSAY; SALMONELLA; EPIDEMIOLOGY; MECHANISMS; FREQUENCY; SHIGELLA AB In an effort to find a rapid, efficient, and reliable method for screening and classifying large numbers of tetracycline-resistant bacterial isolates, we developed a multiplex, real-time PCR assay using SYBR Green I and the Roche LightCycler. The assay can rapidly identify eight genes encoding tetracycline resistance efflux pumps including tet(A), tet(B), tet(C), tet(D), tet(E), tet(G). tet(H) and tet(J). Primers were selected for PCR amplification of these eight tetracycline resistance determinant (tet) genes commonly found in Gram-negative organisms. We combined printer pairs together to make a single-tube Multiplex PCR reaction followed by melting curve analysis. Amplification of the expected tet gene products was confirmed by both agarose gel elect ropho resi s and DNA sequence analysis. Based oil melting temperature differences, we Could identify the different classes of tet genes. To test the multiplex PCR, the assay was used on 107 tetracycline-resistant clinical isolates of various Gram-negative organisms isolated in several locations around the world. About 49.5% of those strains carried a tet(A) gene, 35.5% carried a tet(B), 7.5% carried a tet(J), 5.6% carried a fet(C) and 1.9% carried a tet(D) gene. DNA sequence analysis of the amplicons confirmed that the specificity of the test was 100%. The sensitivity of the Multiplex test varied from 10 to 1000 CFU per PCR reaction. Our real time PCR assay utilizing SYBR Green I and melting point analysis on the Lightcycler system showed not only a high confidence level in differentiation of the classes of tet genes but also precise reproducibility. Our multiplex PCR tet gene class identification assay offers a significant savings of time and labor in the analysis of large numbers of clinical strains compared with assays using individual gene PCR or traditional phenotype methods. Published by Elsevier Ltd. C1 Walter Reed Army Inst Res, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA. Univ Maryland, Ctr Heart, College Pk, MD 20742 USA. RP Lindler, LE (reprint author), Dept Def Global Emerging Infect Surveillance & R, Silver Spring, MD 20910 USA. EM luther.lindler@us.army.mil NR 32 TC 26 Z9 40 U1 4 U2 16 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0890-8508 J9 MOL CELL PROBE JI Mol. Cell. Probes PD AUG PY 2007 VL 21 IS 4 BP 245 EP 256 DI 10.1016/j.mcp.2006.12.005 PG 12 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology GA 176QG UT WOS:000247099400001 PM 17367991 ER PT J AU Bryndol, S Yaron, D Block, R AF Sones, Bryndol Danon, Yaron Block, Robert TI Production and application of a novel energy-tunable X-ray source at the RPI LINAC SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 19th International Conference on Application of Accelerators in Research and Industry CY AUG 20-25, 2006 CL Ft Worth, TX SP Lawrence Berkeley Natl Lab, Lawrence Livemore Natl Lab, Los Alamos Natl Lab, Natl Canc Inst, Oak Ridge Associated Univ, Oak Ridge Natl Lab, Sandia Natl Lab, Univ N Texas, AccSys Technol Inc, Comecer SRL, Natl Electrostat Corp, Synergy Vacuum DE parametric X-rays; PXR; crystal; copper; tungsten; imaging; LINAC ID FLUORIDE LIF CRYSTAL; ANGULAR-DISTRIBUTION; RADIATION; PXR; ELECTRONS AB The 60-MeV electron linear accelerator at Rensselaer Polytechnic Institute (RPI) is used to produce parametric X-rays (PXR). PXR is an intense, quasi-monochromatic, energy-tunable, and polarized X-ray source derived from the interaction of relativistic electrons with the periodic structure of crystal materials. Experiments were performed using highly oriented pyrolytic graphite (HOPG), LiF, Si, Ge, Cu, and W target crystal radiators. Smooth X-ray energy tunability is achieved by rotating the crystal with respect to the electron beam direction. Measured energy linewidths consistently agreed with predicted values except in cases using lower quality HOPG. When the predicted energy linewidth was narrower than our Si X-ray detector resolution (350 eV at 17.5 KeV), a near-absorption edge transmission technique that takes advantage of the PXR energy tunabilty was used to measure the PXR energy linewidth for example, Si(400) FWHM of 134 eV at 9.0 keV (2%). Per electron, the photon production efficiency of PXR is comparable to synchrotron radiation sources. A theoretical model that considers electron multiple scattering, electron divergence, and crystal mosaicity was used to broaden the PXR photon distribution in order to calculate the predicted PXR photon yield. Comparing measurements and calculations resulted in a typical relative error below 50%. In some cases with LiF, the differences between predicted and measured values were as low as 2% for LiF(4 0 0). Finally, this work reports for the first-time PXR imaging. This was achieved using LiF(2 2 0) interacting with 56 MeV electrons with electron beam currents up to 6 mu A. The LiF and graphite PXR target crystals were compared for use in soft tissue imaging, e.g. mammography using energies 17-20 keV. Low Z materials like graphite and LiF were most suitable for PXR production because of their low Bremsstrahlung production, electron scattering, and photon absorption. Graphite was more efficient at producing PXR photons while the LiF energy line width was narrower. (c) 2007 Elsevier B.V. All rights reserved. C1 Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, Troy, NY 12180 USA. US Mil Acad, Dept Phys, ATTN MADN PHYS, West Point, NY 10996 USA. RP Yaron, D (reprint author), Rensselaer Polytech Inst, Dept Mech Aerosp & Nucl Engn, NES 1-9,110 8th St, Troy, NY 12180 USA. EM danony@rpi.edu NR 21 TC 4 Z9 4 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD AUG PY 2007 VL 261 IS 1-2 BP 98 EP 101 DI 10.1016/j.nimb.2007.03.034 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA 200SW UT WOS:000248784100026 ER PT J AU Colyer, MH Weber, ED Weichel, ED Dick, JSB Bower, KS Ward, TP Haller, JA AF Colyer, Marcus H. Weber, Eric D. Weichel, Eric D. Dick, John S. B. Bower, Kraig S. Ward, Thomas P. Haller, Julia A. TI Delayed intraocular foreign body removal without endophthalmitis during operations Iraqi freedom and enduring freedom SO OPHTHALMOLOGY LA English DT Article; Proceedings Paper CT 110th Annual Meeting of the American-Academy-of-Ophthalmology CY NOV 11-14, 2006 CL Las Vegas, NV SP Amer Acad Ophthalmol ID COMBINED PENETRATING KERATOPLASTY; PARS-PLANA VITRECTOMY; ECKARDT TEMPORARY KERATOPROSTHESIS; VITREORETINAL SURGERY; PROGNOSTIC-FACTORS; POSTERIOR SEGMENT; OCULAR TRAUMA; RETINAL-DETACHMENT; VISUAL-ACUITY; DESERT-SHIELD AB Objective: To report the long-term follow-up results of intraocular foreign body (IOFB) removal at Walter Reed Army Medical Center during Operation Iraqi Freedom and Operation Enduring Freedom from February 2003 through November 2005 and to determine the prognostic factors for visual outcome in this patient population. Design: Retrospective, noncomparative, interventional case series. Participants: Seventy-nine eyes of 70 United States military soldiers deployed in support of operations Iraqi Freedom and Enduring Freedom sustained IOFB injuries and subsequently were treated at the Walter Reed Army Medical Center with a minimum of 6 months of follow-up. Intervention: The principal procedure performed was 20-gauge 3-port vitrectomy with IOFB removal through limbal or pars plana incision. Main Outcome Measures: Final visual acuity, rate of proliferative vitreoretinopathy, rate of endophthalmitis. Results: Average patient age was 27 years, with an average of 331 days of postoperative follow-up. Average IOFB size was 3.7 mm (range, 0.1-20 mm). Median time to IOFB removal was 21 days (mean, 38 days; range, 2-661 days). Mean preoperative visual acuity was 20/400 (1.36 logarithm of mean angle of resolution [logMAR] units) and mean final visual acuity was 20/120 (0.75 logMAR). Of the patients, 53.4% achieved visual acuity of 20/40 or better, whereas 77.5% achieved visual acuity of better than 20/200. There were no cases of endophthalmitis (0/79 eyes; 95% confidence interval, 0%-3.1%), siderosis bulbi, or sympathetic ophthalmia. Among the eyes, 10.3% evolved to no light perception or had been enucleated by the 6-month follow-up visit. Poor visual outcome correlated with extensive intraocular injury (P<0.032). Seventeen of 79 eyes (21%) experienced proliferative vitreoretinopathy. Proliferative vitreoretinopathy correlated with poor initial vision (hand movements or worse; P = 0.035) and extensive intraocular injury (P<0.001). Timing of vitrectomy did not correlate with visual outcome. The most common systemic antibiotic administered was levofloxacin, whereas the most common topical antibiotic administered was moxifloxacin. Conclusions: Poor visual outcome and postoperative complication rates are related to extensive intraocular injury. Delayed IOFB removal with a combination of systemic and topical antibiotic coverage can result in good visual outcome without an apparent increased risk of endophthalmitis or other deleterious side effects. C1 Walter Reed Army Med Ctr, Ophthalmol Serv, Washington, DC 20307 USA. Kaiser Permanente Hlth Syst, San Diego, CA USA. Johns Hopkins Univ, Wilmer Ophthalmol Inst, Baltimore, MD 21218 USA. RP Colyer, MH (reprint author), Walter Reed Army Med Ctr, Ophthalmol Serv, 1F,6900 Georgia Ave NW, Washington, DC 20307 USA. EM marcus.colyer@na.amedd.army.mil NR 44 TC 60 Z9 67 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD AUG PY 2007 VL 114 IS 8 BP 1439 EP 1447 DI 10.1016/j.ophtha.2006.10.052 PG 9 WC Ophthalmology SC Ophthalmology GA 195BL UT WOS:000248387400004 PM 17331579 ER PT J AU Smith, RB Sniezek, JC Weed, DT Wax, MK AF Smith, Russell B. Sniezek, Joseph C. Weed, Donald T. Wax, Mark K. CA Microvascular SURG Subcommi TI Utilization of free tissue transfer in head and neck surgery SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Review ID FOREARM FREE-FLAP; MICROVASCULAR ANASTOMOTIC DEVICE; QUALITY-OF-LIFE; PEDICLED FLAP; OROPHARYNGEAL CANCER; FUNCTIONAL OUTCOMES; VENOUS ANASTOMOSES; ABLATIVE SURGERY; DOPPLER PROBE; RECONSTRUCTION AB Objective: Free tissue transfer is frequently incorporated into the reconstructive algorithm for a multitude of defects in the head and neck. With the increasing usage of free tissue transfer we undertook to review the most current advances in the field. Data sources: PubMed search of all pertinent articles as they related to oropharyngeal reconstruction, flap choice, new technologies and techniques, and outcomes. Articles were chosen based on reviewer selection. Methods: The microvascular committee met and discussed the current important topics in free tissue transfer. A priority list was created and ranked. Topics were assigned to the authors who conducted a narrative review of the literature. Results: Free tissue transfer has evolved to the point where a limited number of specific flaps are now utilized for most defects. Composite tissue is used to reconstruct composite defects. The coupling device and implantable Doppler are demonstrating a positive impact on flap survival and efficiency. Finally, outcomes in terms of quality of life, swallowing, and return to function have been shown to improve with the use of free tissue transfer. Conclusion: Free tissue transfer continues to be the reconstructive modality of choice for head and neck defects. (C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. Univ Iowa, Coll Med, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA. Tripler Army Med Ctr, Honolulu, HI USA. Univ Miami Miller, Sch Med, Coral Gables, FL 33124 USA. RP Smith, RB (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, 3181 SW San Jackson Pk Rd PV-01, Portland, OR 97201 USA. NR 61 TC 48 Z9 49 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD AUG PY 2007 VL 137 IS 2 BP 182 EP 191 DI 10.1016/j.otohns.2007.04.011 PG 10 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 200UE UT WOS:000248787500002 PM 17666238 ER PT J AU Xie, L Li, Q Johnson, J Zhang, J Milhous, W Kyle, D AF Xie, L. Li, Q. Johnson, J. Zhang, J. Milhous, W. Kyle, D. TI Development and validation of flow cytometric measurement for parasitaemia using autofluorescence and YOYO-1 in rodent malaria SO PARASITOLOGY LA English DT Article DE parasitaemia; flow cytometry; microscopy; YOYO-1; malaria-infected rat ID PLASMODIUM-BERGHEI; BLOOD-CELLS; DIAGNOSIS; GLUTARALDEHYDE; ERYTHROCYTES; RETICULOCYTE; ARTELINATE; ARTESUNATE; HEMOLYSIS; AGENTS AB An automated flow cytometric (FCM) detection method has been developed and validated with a simple diagnostic procedure in parasitized erythrocytes of Plasmodium berghei-infected rats using the nucleic acid-binding fluorescent dye YOYO-1. High levels of reticulocytes were detected during the course of the infection, ranging from 1 center dot 2 center dot 51 center dot 2%,, but any RNA potentially confounding the assay could be removed by digestion with RNAse. The cell counts of uninfected, infected, and nucleated cells occurred with high precision. The cells were divided into different populations according to their physical or chemical properties but various factors within the assay such as cell fixation, RNA digestion, and compensation required optimization. In this study, FCM greatly simplified and accelerated parasite detection, with a mean precision of 44%, specificity of 98-9% and accuracy of 101 center dot 3%. The detection and quantitation limits in the assay were 0 center dot 024% and 0 center dot 074% parasitaemia, respectively. Overall, the parasite counts by FCM measurement correlated highly (r(2)=0 center dot 954-0 center dot 988) with the parasitaemia measured by light microscopical analysis when animals treated with suppressive, clearance, and curative doses of novel antimalarial drugs were examined. The lower levels of parasitaemia (30%) detected by microscopy compared to FCM may be related to a number of schizonts externally attached to the erythrocyte membranes that normally would not be included in microscopy counting. Lower sampling error and reliable identification of rodent erythrocyte parasites based on the principles of FCM have replaced the traditional blood smear in our laboratory. C1 Walter Reed Army Inst Res, Dept Pharmacol, Div Ecpt Therapeut, Silver Spring, MD 20910 USA. RP Li, Q (reprint author), Walter Reed Army Inst Res, Dept Pharmacol, Div Ecpt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM qigui.li@na.amedd.army.mil NR 35 TC 15 Z9 16 U1 2 U2 4 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0031-1820 J9 PARASITOLOGY JI Parasitology PD AUG PY 2007 VL 134 BP 1151 EP 1162 DI 10.1017/S0031182007002661 PN 9 PG 12 WC Parasitology SC Parasitology GA 198VE UT WOS:000248654800002 PM 17445324 ER PT J AU Killgore, WDS Kendall, AP Richards, JM McBride, SA AF Killgore, William D. S. Kendall, Athena P. Richards, Jessica M. McBride, Sharon A. TI Lack of degradation in visuospatial perception of line orientation after one night of sleep loss SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID DECISION-MAKING; BISECTION JUDGMENTS; NEURAL BASIS; DEPRIVATION; ATTENTION; FMRI; ASYMMETRIES; VOLUNTEERS; ACCURACY; THINKING AB Sleep deprivation impairs a variety of cognitive abilities including vigilance, attention, and executive function. Although sleep loss has been shown to impair tasks requiring visual attention and spatial perception, it is not clear whether these deficits are exclusively a function of reduced attention and vigilance or if there are also alterations in visuospatial perception. Visuospatial perception and sustained vigilance performance were therefore examined in 54 healthy, volunteers at rested baseline and again after one night of sleep deprivation using the judgment of Line Orientation Test and a Computerized test of psychomotor vigilance. Whereas psychomotor vigilance declined significantly from baseline to sleep-deprived testing, scores on the judgment of Line Orientation did not change significantly. Results suggest that documented performance deficits associated with sleep loss are unlikely to be the result of dysfunction within systems of the brain responsible for simple visuospatial perception and processing of line angles. C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, Silver Spring, MD 20910 USA. RP Killgore, WDS (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Behav Biol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. OI Killgore, William/0000-0002-5328-0208 NR 38 TC 8 Z9 10 U1 0 U2 0 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD AUG PY 2007 VL 105 IS 1 BP 276 EP 286 PG 11 WC Psychology, Experimental SC Psychology GA 210FE UT WOS:000249441300035 PM 17918576 ER PT J AU Na, DH Faraj, J Capan, Y Leung, KP DeLuca, PP AF Na, Dong Hee Faraj, Jabar Capan, Yilmaz Leung, Kai P. DeLuca, Patrick P. TI Stability of antimicrobial decapeptide (KSL) and its analogues for delivery in the oral cavity SO PHARMACEUTICAL RESEARCH LA English DT Article DE antimicrobial peptide; antiplaque agent; chewing gum; peptide analogue; stability ID ANTI-PLAQUE AGENTS; CHEWING GUM; MASS-SPECTROMETRY; CHLORHEXIDINE; MICROSPHERES; PREVENTION; PEPTIDES; RELEASE AB Purpose. To investigate the stability of KSL, an antimicrobial decapeptide, and its analogues, in human saliva and simulated gastric fluid for delivery in the oral cavity. Materials and Methods. The degradation products of KSL in human saliva and simulated gastric fluid were separated by reversed-phase HPLC and their structures were identified by electrospray ionization-mass spectrometry. Analogues of KSL were synthesized by solid-phase synthesis procedure. Their enzymatic stabilities and antimicrobial activities were studied. Results. KSL was degraded by the peptide bond cleavages at Lys(6) - Val(7) in the human saliva and Phe(5) Lys(6) in simulated gastric fluids. Three analogues of KSL were synthesized; the Lys(6) residue was either methylated (KSL-M), or replaced with Trp ( KSL-W), or the d-form of Lys (KSL-D). The KSL analogues were much more stable than the native KSL, with the rank order of stability being KSL-D > KSL- W > KSL- M > KSL in human saliva. However, in simulated gastric fluid, while KSL- D was still stable, KSL- W was significantly degraded. In addition, KSL- D significantly lost the antimicrobial activity, whereas KSL- W completely preserved the activity against several oral bacteria. In a chewing gum formulation, KSL- W showed a more sustained release profile as compared with the native KSL. Conclusion. This study suggests that KSL- W could be used as an antiplaque agent in a chewing gum formulation. C1 Univ Kentucky, Coll Pharm, Fac Pharmaceut Sci, Lexington, KY 40536 USA. Kyungsung Univ, Coll Pharm, Pusan 608736, South Korea. Hacettepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06100 Ankara, Turkey. USA, Walter Reed Army Inst Res, Dent & Trauma Res Detachment, Microbiol Branch, Great Lakes, IL 60088 USA. RP DeLuca, PP (reprint author), Univ Kentucky, Coll Pharm, Fac Pharmaceut Sci, 725 Rose St, Lexington, KY 40536 USA. EM ppdelu1@uky.edu NR 18 TC 17 Z9 20 U1 0 U2 6 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0724-8741 J9 PHARM RES JI Pharm. Res. PD AUG PY 2007 VL 24 IS 8 BP 1544 EP 1550 DI 10.1007/s11095-007-9274-8 PG 7 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA 181YS UT WOS:000247472900015 PM 17380259 ER PT J AU Lalliss, SJ Branstetter, JG Murray, CK Ficke, JR Jenkins, DH AF Lalliss, Steven J. Branstetter, Joanna G. Murray, Clinton K. Ficke, James R. Jenkins, Donald H. TI Infection rates in US military personnel using vacuum-assisted closure SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Letter ID INJURIES C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Lalliss, SJ (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM steven.lalliss@cen.amedd.army.mil NR 5 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD AUG PY 2007 VL 120 IS 2 BP 574 EP 575 DI 10.1097/01.prs.0000267671.78598.b4 PG 2 WC Surgery SC Surgery GA 194GY UT WOS:000248333900036 PM 17632372 ER PT J AU Fernandes, G Fuschetto, J Filipi, Z Assanis, D Mckee, H AF Fernandes, G. Fuschetto, J. Filipi, Z. Assanis, D. Mckee, H. TI Impact of military JP-8 fuel on heavy-duty diesel engine performance and emissions SO PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART D-JOURNAL OF AUTOMOBILE ENGINEERING LA English DT Article DE diesel engine; aviation fuel; JP-8; emissions; calibration AB Investigating the impact of jet fuel on diesel engine performance and emissions is very important for military vehicles, due to the US Army Single Fuel Forward Policy mandating that deployed vehicles must refuel with aviation fuel JP-8. There is a known torque and fuel economy penalty associated with the operation of a diesel engine with JP-8 fuel, due to its lower density and viscosity. On the other hand, a few experimental studies have suggested that kerosene-based fuels have the potential for lowering exhaust emissions, especially particulate matter, compared to diesel fuel #2 (DF-2). However, studies so far have typically focused on quantifying the effects of simply replacing the regular DF-2 with JP-8, rather than fully investigating the reasons behind the observed differences. This research evaluates the effect of using JP-8 fuel in a heavy-duty diesel engine on fuel injection, combustion, performance, and emissions, and subsequently utilizes the obtained insight to propose changes to the engine calibration to mitigate the impact of the trade-offs. Experiments were carried out on a Detroit Diesel Corporation (DDC) S60 engine outfitted with exhaust gas recirculation (EGR). The results indicate that torque and fuel economy of diesel fuel can be matched, without smoke or NO, penalty, by increasing the duration of injection to compensate for the lower fuel density. The lower cetane number of JP-8 caused an increased ignition delay and increased premixed combustion, and their cumulative effect led to relatively unchanged combustion phasing. Under almost all conditions, JP-8 led to lower NO., and particulate matter (PM) emissions and shifted the NOx-PM trade-off favourably. C1 Univ Michigan, Ctr Automat Res, Dept Mech Engn, Ann Arbor, MI 48109 USA. Univ Michigan, Ctr Automat Res, Ann Arbor, MI 48109 USA. USA, Natl Automot Ctr, RDECOM, Warren, MI USA. RP Assanis, D (reprint author), Univ Michigan, Ctr Automat Res, Dept Mech Engn, Ann Arbor, MI 48109 USA. EM assanis@umich.edu NR 21 TC 28 Z9 28 U1 0 U2 3 PU PROFESSIONAL ENGINEERING PUBLISHING LTD PI WESTMINISTER PA 1 BIRDCAGE WALK, WESTMINISTER SW1H 9JJ, ENGLAND SN 0954-4070 J9 P I MECH ENG D-J AUT JI Proc. Inst. Mech. Eng. Part D-J. Automob. Eng. PD AUG PY 2007 VL 221 IS D8 BP 957 EP 970 DI 10.1243/09544070JAUTO211 PG 14 WC Engineering, Mechanical; Transportation Science & Technology SC Engineering; Transportation GA 214NR UT WOS:000249745700006 ER PT J AU Powell, BS Enama, JT Ribot, WJ Webster, W Little, S Hoover, T Adamovicz, JJ Andrews, GP AF Powell, Bradford S. Enama, Jeffrey T. Ribot, Wilson J. Webster, Wendy Little, Stephen Hoover, Timothy Adamovicz, Jeffrey J. Andrews, Gerard P. TI Multiple asparagine deamidation of Bacillus anthracis protective antigen causes charge Isoforms whose complexity correlates with reduced biological activity SO PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS LA English DT Article; Proceedings Paper CT 57th Annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (PITTCON 2006) CY MAR 13-16, 2006 CL Orlando, FL DE anthrax vaccine; anthrax toxin; protein degradation; iso-aspartate; succinimide intermediate; heavy isotope; two-dimensional gel electrophoresis; capillary isoelectric focusing; computational model; liquid chromatography-ion trap tandem mass spectrometry ID ELECTRON-CAPTURE DISSOCIATION; LETHAL FACTOR; EDEMA FACTOR; NONENZYMATIC DEAMIDATION; SPONTANEOUS DEGRADATION; ISOASPARTATE FORMATION; SUCCINIMIDE FORMATION; INHALATIONAL ANTHRAX; GEL-ELECTROPHORESIS; PROTEIN DEAMIDATION AB Protective antigen is essential for the pathology of Bacillus anthracis and is the proposed immunogen for an improved human anthrax vaccine. Known since discovery to comprise differentially charged isoforms, the cause of heterogeneity has eluded specific structural definition until now. Recombinant protective antigen (rPA) contains similar isoforms that appear early in fermentation and are mostly removed through purification. By liquid chromatography-tandem mass spectrometry sequencing of the entire protein and inspection of spectral data for amino acid modifications, pharmaceutical rPA contained measurable deamidation at seven of its 68 asparagine residues. A direct association between isoforin complexity and percent deamidation was observed such that each decreased with purity and increased with protein aging. Position N537 consistently showed the highest level of modification, although its predicted rate of deamidation ranked 10th by theoretical calculation, and other asparagines of higher predicted rates were observed to be unmodified. rPA with more isoforms and greater deamidation displayed lower activities for furin cleavage, heptainerization, and holotoxin formation. Lethal factor-mediated macrophage toxicity correlated inversely with deamidation at residues N466 and N408. The described method measures deamidation without employing theoretical isotopic distributions, comparison between differentially treated samples or computational predictions of reactivity rates, and is broadly applicable to the characterization of other deamidated proteins. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Powell, BS (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM bradford.powell@det.amedd.army.mil NR 86 TC 12 Z9 12 U1 0 U2 3 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0887-3585 J9 PROTEINS JI Proteins PD AUG 1 PY 2007 VL 68 IS 2 BP 458 EP 479 DI 10.1002/prot.21432 PG 22 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA 179IX UT WOS:000247284100004 PM 17469195 ER PT J AU Bobo, WV Warner, CH Warner, CM AF Bobo, Williain V. Warner, Christopher H. Warner, Carolynn M. TI The management of post traumatic stress disorder (PTSD) in the primary care setting SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE post traumatic stress disorder; anxiety ID PHARMACOTHERAPY; SYMPTOMS AB Recent geopolitical events, including the terrorist attacks on the United States on September 11, 2001, and ongoing military operations in Iraq, have raised awareness of the often severe psychological after-effects of these and other types of traumatic events. Post traumatic stress disorder (PTSD) represents the most severe of these sequelae. PTSD is an under-recognized and under-treated chronic anxiety disorder associated with significant psychosocial morbidity, substance abuse, and a number of other negative health outcomes. Fortunately, the biologic underpinnings of this complex disorder and new advances in treatment are being realized. Early detection by primary care providers and rapid initiation of treatment are the keys to successful management of the disorder. C1 Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN USA. Med Coll Wisconsin, Dept Clin Psychiat & Behav Sci, Milwaukee, WI 53226 USA. USA, Infantry Div 3, Div Psychiat, Ft Stewart, GA USA. Winn Army Community Hosp, Dept Family Practice, Ft Stewart, GA USA. RP Warner, CH (reprint author), 373 Steeple Chase Lane, Richmond Hill, GA 31324 USA. EM chrisotpher.h.warner@us.army.mil NR 19 TC 4 Z9 4 U1 1 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2007 VL 100 IS 8 BP 797 EP 802 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 199JO UT WOS:000248692200010 PM 17713306 ER PT J AU Prince, LK Shah, AA Martinez, LJ Moran, KA AF Prince, Lisa K. Shah, Anita A. Martinez, Luis J. Moran, Kimberly A. TI Ehrlichiosis: Making the diagnosis in the acute setting SO SOUTHERN MEDICAL JOURNAL LA English DT Article DE ehrlichiosis; human monocytic ehrlichiosis; tickborne rickettsial diseases; serology ID EPIDEMIOLOGY AB Human monocytic ehrlichiosis (HME) is a tick-borne disease transmitted during the summer months in the mid-Atlantic, southeastern and south-central United States. A large proportion of patients presenting with ehrlichiosis must be hospitalized because of the severity of their presenting signs, symptoms and lab abnormalities. We report a case of HME presenting with negative serologies and positive DNA PCR for Ehrlichia chaffeensis during the acute illness. The patient was empirically treated with doxycycline before the availability of diagnostic test results and had a rapid recovery. This report summarizes the common findings of ehrlichiosis on presentation, diagnostic strategies, and treatment options. This case emphasizes the importance of considering tick-borne diseases in the differential diagnosis for patients presenting with nonspecific febrile syndromes in endemic areas and using the clinical scenario to determine whether empiric treatment for a tick-borne disease is necessary. Delaying treatment while awaiting confirmatory tests is unnecessary, and may result in a less favorable patient outcome. C1 Walter Reed Army Med Ctr, Dept Infect Dis, Washington, DC 20307 USA. RP Prince, LK (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, Ward 74, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 8 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0038-4348 J9 SOUTH MED J JI South.Med.J. PD AUG PY 2007 VL 100 IS 8 BP 825 EP 828 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 199JO UT WOS:000248692200014 PM 17713310 ER PT J AU McDonough, J Tinnel, CB AF McDonough, James Tinnel, Captain Brent TI The University of Pennsylvania/Walter Reed Army Medical Center proton therapy program SO TECHNOLOGY IN CANCER RESEARCH & TREATMENT LA English DT Article; Proceedings Paper CT Symposium on Developing and Understanding a Hospital-based Proton Facility - Bringing Physics into Medicine CY OCT 18-20, 2006 CL Indian Wells, CA DE proton therapy; facility design; telemedicine AB The design of the proton therapy center being constructed at the University of Pennsylvania is based on several principles that distinguish it from other proton facilities. Among these principles is the recognition that advances in imaging, and particularly in functional imaging, will have a large impact on radiotherapy in the near future and that the conformation of proton dose distributions can utilize that information to a larger degree than other treatment techniques. The facility will contain four-dimensional CT-simulators, an MR-simulator capable of spectroscopy, and a PET-CT scanner. A second principle applied to the facility design is to incorporate into proton radiotherapy the recent progress in conventional radiotherapy; including imaging and monitoring of patients during treatment, imaging of soft tissue, accounting for respiratory motion, and expanding the use of intensity-modulated treatments. A third principle is to understand that the facility must be operated efficiently. To that end the specifications for the equipment have included requirements for high beam intensity, fast switching times between treatment rooms, a multileaf collimator to permit multiple fields to be treated quickly, and plans for an intelligent beam scheduler to determine where the beam can be best used at any given time. We expect to use "universal" nozzles, which can switch rapidly from scattering mode to scanning mode, and there will be a set-up room used for the first day of treatment to verify alignment rather than spend valuable time in a gantry room. Many of these ideas require development, including the applications of existing radiotherapy techniques to proton gantries, so a series of research and development projects have started to address these issues. Walter Reed Army Medical Center, which will provide a portal through which military personnel and their dependants can receive proton radiotherapy, is involved in several of these development projects as well as the creation of process to remotely perform treatment planning for the military patients under treatment at the proton facility. C1 Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA. Walter Reed Army Med Ctr, Radiat Therapy Clin, Washington, DC 20307 USA. RP McDonough, J (reprint author), Univ Penn, Dept Radiat Oncol, 3400 Spruce St, Philadelphia, PA 19104 USA. EM mcdonough@xrt.upenn.edu NR 0 TC 2 Z9 2 U1 0 U2 0 PU ADENINE PRESS PI SCHENECTADY PA 2066 CENTRAL AVE, SCHENECTADY, NY 12304 USA SN 1533-0346 J9 TECHNOL CANCER RES T JI Technol. Cancer Res. Treat. PD AUG PY 2007 VL 6 IS 4 SU S BP 73 EP 76 PG 4 WC Oncology SC Oncology GA 207VT UT WOS:000249279900012 PM 17668956 ER PT J AU Wagner, SJ Skripchenko, A Salata, J Cardo, LJ AF Wagner, Stephen J. Skripchenko, Andrey Salata, Jeanne Cardo, Lisa J. TI Photoinactivation of Trypanosoma cruzi in red cell suspensions with thiopyrylium SO TRANSFUSION AND APHERESIS SCIENCE LA English DT Article ID CHAGAS-DISEASE; LOS-ANGELES; INACTIVATION; REDUCTION; PLASMA; LIGHT AB Chagas disease, endemic in rural areas of Mexico, Central and South America, is caused by the protozoan parasite, Trypanosma cruzi, which is spread by the Reduviid bug and also by transfusion or organ transplant. Transmission of the organism from asymptomatic donors to immunocompromised recipients, leads to clinically apparent disease. With recent immigration patterns, T. cruzi is now becoming an increasing problem in non-endemic areas of North America and Europe. Blood screening tests for T. cruzi are being developed, and one test is currently licensed by the United States Food and Drug Administration and has been implemented in some US blood centers. This study alternatively investigates the potential for a novel DNA-intercalating photosensitizer, thiopyrylium (TP), to inactivate T. cruzi in red cell suspensions. With complete inactivation using 6.3 mu M of TP and 1.1 J/cm(2) red light treatment, results suggest that the organism is highly sensitive to photoinactivation under conditions much less stringent than those that have been previously demonstrated to maintain red cell (RBC) properties during 42 day storage. (c) 2007 Elsevier Ltd. All rights reserved. C1 Amer Red Cross, Holland Lab, Rockville, MD 20855 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Wagner, SJ (reprint author), Amer Red Cross, Holland Lab, 15601 Crabbs Branch Way, Rockville, MD 20855 USA. EM wagners@usa.redcross.org FU NHLBI NIH HHS [HL66770, R01 HL066779-05, R01 HL066779] NR 15 TC 7 Z9 8 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 1473-0502 J9 TRANSFUS APHER SCI JI Transfus. Apher. Sci. PD AUG PY 2007 VL 37 IS 1 BP 23 EP 25 DI 10.1016/j.transci.2007.03.014 PG 3 WC Hematology SC Hematology GA 233QI UT WOS:000251105000004 PM 17698414 ER PT J AU Schwartz, BF Dykes, TE Rubenstein, JN Stackhouse, GB Stoller, ML AF Schwartz, Bradley F. Dykes, Thomas E. Rubenstein, Jonathan N. Stackhouse, G. Bennett Stoller, Marshall L. TI Effect of body position on renal parenchyma perfusion as measured by nuclear scintigraphy SO UROLOGY LA English DT Article ID HYPERTENSION AB OBJECTIVES To compare differential renal perfusion in various body positions in healthy volunteers, to help postulate factors responsible for recurrent unilateral stone formation. METHODS Ten volunteers with normal renal function and no history of urinary disease were evaluated with diuretic renography using mercaptoacetyl-triglycine. Scintigraphy was performed I week apart in each of three typical sleep positions (supine, left lateral decubitus, right lateral decubitus), and renal perfusion was measured. RESULTS Symmetric renal perfusion was noted in all volunteers in the supine position. Subjects positioned in the left lateral decubitus position had a mean renal perfusion of 61.3% in the dependent (left) kidney, compared with 38.7% in the nondeperident (right) kidney (P < 0.05). In the right lateral decubitus position, the mean renal perfusion in the right kidney was 63.3%, whereas that in the left kidney measured 36.7% (P < 0.05). Renal perfusion in the dependent kidney was increased when compared with the same kidney in the supine position in both the left and right kidneys. CONCLUSIONS Body position had a significant effect on renal perfusion as measured by nuclear renal scintigraphy. If altered renal blood flow contributes to urinary calculogenesis, these data suggest that the urinary and vascular milieu in the decubitus position may contribute to risk factors for stone formation. C1 So Illinois Univ, Sch Med, Ctr Laparoscopy & Endourol, Dept Urol, Springfield, IL 62794 USA. Tripler Army Med Ctr, Serv Urol, Honolulu, HI USA. Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA. RP Schwartz, BF (reprint author), So Illinois Univ, Sch Med, Ctr Laparoscopy & Endourol, Dept Urol, POB 19665, Springfield, IL 62794 USA. EM bschwartz.@siumed.edu NR 11 TC 4 Z9 5 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD AUG PY 2007 VL 70 IS 2 BP 227 EP 229 DI 10.1016/j.urology.2007.03.057 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA 211WV UT WOS:000249554900003 PM 17826475 ER PT J AU Haseman, MK Rosenthal, SA Kipper, SL Trout, JR Manyak, MJ AF Haseman, Michael K. Rosenthal, Seth A. Kipper, Samuel L. Trout, J. Richard Manyak, Michael J. TI Central abdominal uptake of indium-111 capromab pendetide (ProstaScint) predicts for poor prognosis in patients with prostate cancer SO UROLOGY LA English DT Article ID RADICAL PROSTATECTOMY; MEMBRANE ANTIGEN; (111)INDIUM-CAPROMAB PENDETIDE; INDIUM-111-CAPROMAB PENDETIDE; CARCINOMA; RADIOIMMUNOSCINTIGRAPHY; RADIOTHERAPY; THERAPY; TOMOGRAPHY; BIOPSY AB OBJECTIVES Central abdominal uptake (CAU) on immunoscintigraphy with capromab pendetide (CP) (ProstaScint) suggests the presence of metastases from prostate cancer, but tissue confirmation is difficult and invasive. We report the Outcomes data from a cohort of patients with CAU on CP images obtained for staging. METHODS The records of 341 men with prostate cancer who underwent CP imaging at two institutions from 1994 to 1999 were reviewed. The patients were divided according to the presence or absence of CAU. Metastases were confirmed in 36 patients (52%) with CAU. The median follow-up was 4.1 years. Statistical analyses compared the differences in baseline characteristics, subsequent radiotherapy, intervention with androgen ablation, and survival. RESULTS CAU was detected in 69 patients (20%). A total of 262 patients underwent pelvic radiotherapy after the scan, 57 (83%) with CAU and 205 (75%) without (P = 0-2). Of the 69 patients with positive CAU findings and the 272 patients with negative CAU findings, 10 (14.5%) and 14 (5.1%) had died during the follow-up period (P = 0.007). Prostate cancer-specific death occurred in 5 (7.2%) of 69 patients with CAU-positive findings versus 2 of 272 with CAU-negative findings, for a rate 10 times greater in the CAU-positive group (P = 0.02). The results were independent of either the use or timing of androgen blockade. CONCLUSIONS The results Of Our study have shown that CAU on CP immunoscintigraphy is clinically important and correlates with a significantly greater risk of prostate cancer-specific death. These findings Suggest that patients with CAU should be considered for earlier intervention with systemic therapy. C1 Radiol Assoc Sacramento, Sacramento, CA 95815 USA. Pacific Coast Imaging, Irvine, CA USA. Rutgers State Univ, New Brunswick, NJ 08903 USA. Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. Cytel Corp, Princeton, NJ USA. RP Haseman, MK (reprint author), Radiol Assoc Sacramento, 1500 Expo Pkwy, Sacramento, CA 95815 USA. EM RAHaseman@radiological.com NR 28 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD AUG PY 2007 VL 70 IS 2 BP 303 EP 308 DI 10.1016/j.urology.2007.03.069 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA 211WV UT WOS:000249554900022 PM 17826494 ER PT J AU Nell, P Kohl, KS Graham, PL LaRussa, PS Marcy, SM Fulginiti, VA Martin, B Trolin, I Norton, SA Neff, JM AF Nell, Patricia Kohl, Katrin S. Graham, Philip L. LaRussa, Philip S. Marcy, S. Michael Fulginiti, Vincent A. Martin, Bryan Trolin, Ingrid Norton, Scott A. Neff, John M. CA Brighton Collaboration Vaccinia Vi TI Eczema vaccinatum as an adverse event following exposure to vaccinia virus: Case definition & guidelines of data collection, analysis, and presentation of immunization safety data SO VACCINE LA English DT Article DE eczema vaccinatum; vaccinia virus; smallpox vaccine; adverse event; immunization; guidelines; case definition ID PARTY DIAGNOSTIC-CRITERIA; SMALLPOX VACCINATION; ATOPIC-DERMATITIS; DARIERS-DISEASE; EPIDEMIOLOGY; BIOTERRORISM; EXPERIENCE; MANAGEMENT; STATEMENT; QUALITY C1 Ctr Dis Control & Prevent, Off Chief Sci Officer, Immunizat Safety Off, Atlanta, GA 30333 USA. USAF, Sturgeon Bay, WI USA. Columbia Univ, New York Prebyterian Hosp, Coll Phys & Surg, Dept Pediat,Dept Epidemiol, New York, NY USA. Univ So Calif, Panorama, CA USA. Univ Calif Los Angeles, Kaiser Fdn Hosp, Sch Med, Panorama, CA USA. Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA. Univ Colorado, Denver, CO 80202 USA. Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC USA. Med Prod Agcy, Uppsala, Sweden. Walter Reed Army Med Ctr, Washington, DC USA. Childrens Hosp & Reg Med Ctr, Seattle, WA USA. RP Kohl, KS (reprint author), Ctr Dis Control & Prevent, Off Chief Sci Officer, Immunizat Safety Off, Atlanta, GA 30333 USA. EM secretariat@brightoncollaboration.org NR 36 TC 5 Z9 5 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 1 PY 2007 VL 25 IS 31 BP 5725 EP 5734 DI 10.1016/j.vaccine.2007.02.085 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 198QZ UT WOS:000248643900007 PM 17532547 ER PT J AU Nell, P Kohl, KS Graham, PL LaRussa, PS Marcy, SM Fulginiti, VA Martin, B McMahon, A Norton, SA Trolin, I AF Nell, Patricia Kohl, Katrin S. Graham, Philip L. LaRussa, Philip S. Marcy, S. Michael Fulginiti, Vincent A. Martin, Bryan McMahon, Ann Norton, Scott A. Trolin, Ingrid CA Brighton Collaboration Vaccinia Vi TI Progressive vaccinia as an adverse event following exposure to vaccinia virus: Case definition and guidelines of data collection, analysis, and presentation of immunization safety data SO VACCINE LA English DT Article DE progressive vaccinia; adverse event; vaccinia virus; smallpox vaccine; immunization; guidelines; case definition ID SMALLPOX VACCINATION; UNITED-STATES; COMPLICATIONS; BIOTERRORISM; QUALITY; TRIALS; RISKS C1 Ctr Dis Control & Prevent, Off Chief Sci Officer, Immunizat Safety Off, Atlanta, GA 30333 USA. USAF, Sturgeon Bay, WI USA. Columbia Univ, New York Presbyterian Hosp, Coll Phys & Surg, Dept Pediat,Dept Epidemiol, New York, NY USA. Univ So Calif, Panorama, CA USA. Univ Calif Los Angeles, Kaiser Fdn Hosp, Sch Med, Panorama, CA USA. Univ Arizona, Dept Pediat, Tucson, AZ 85721 USA. Univ Colorado, Denver, CO 80202 USA. Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC USA. US FDA, Vaccine Safety Branch, Rockville, MD 20857 USA. Walter Reed Army Med Ctr, Washington, DC USA. Med Prod Agcy, Uppsala, Sweden. RP Kohl, KS (reprint author), Ctr Dis Control & Prevent, Off Chief Sci Officer, Immunizat Safety Off, Atlanta, GA 30333 USA. EM secretariat@brightoncollaboration.org NR 24 TC 7 Z9 10 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 1 PY 2007 VL 25 IS 31 BP 5735 EP 5744 DI 10.1016/j.vaccine.2007.02.088 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 198QZ UT WOS:000248643900008 PM 17540484 ER PT J AU Beigel, J Kohl, KS Brinley, F Graham, PL Khuri-Bulos, N LaRussa, PS Nell, P Norton, S Stoltman, G Tebaa, A Warschaw, K AF Beigel, John Kohl, Katrin S. Brinley, Floyd Graham, Philip L. Khuri-Bulos, Najwa LaRussa, Philip S. Nell, Patricia Norton, Scott Stoltman, Gillian Tebaa, Amina Warschaw, Karen CA Brighton Collaboration Vaccinia Vi TI Generalized vaccinia as an adverse event following exposure to vaccinia virus: Case definition and guidelines for data collection, analysis, and presentation of immunization safety data SO VACCINE LA English DT Article DE generalized vaccinia; adverse event; vaccinia virus; smallpox vaccine; immunization; guidelines; case definition ID SMALLPOX VACCINATION; COMPLICATIONS; BIOTERRORISM; STATEMENT; QUALITY; TRIALS C1 Ctr Dis Control & Prevent, Off Chief Sci Officer, Immunizat Safety Off, Atlanta, GA 30333 USA. Natl Inst Hlth, NIG Clin Ctr, Bethesda, MD USA. Natl Inst Hlth, Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA. Columbia Univ, New York Presbyterian Hosp, Coll Phys & Surg, Dept Pediat,Dept Epidemiol, New York, NY USA. Jordan Univ Hosp, Div Pediat Infect Dis, Amman, Jordan. USAF, Sturgeon Bay, WI USA. Walter Reed Army Med Ctr, Washington, DC USA. Michigan Dept Commun Hlth, Div Communicable Dis & Immunizat, Lansing, MI USA. Ctr Antipoison & Pharmacovigilance, Rabat, Morocco. Mayo Clin Scottsdale, Dept Dermatol, Scottsdale, AZ USA. Mayo Clin Scottsdale, Dept Pathol, Scottsdale, AZ USA. RP Kohl, KS (reprint author), Ctr Dis Control & Prevent, Off Chief Sci Officer, Immunizat Safety Off, Atlanta, GA 30333 USA. EM secretariat@brightoncollaboration.org RI Beigel, John/A-7111-2009 NR 21 TC 6 Z9 6 U1 0 U2 3 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD AUG 1 PY 2007 VL 25 IS 31 BP 5745 EP 5753 DI 10.1016/j.vaccine.2007.02.086 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 198QZ UT WOS:000248643900009 PM 17537552 ER PT J AU Ketas, TJ Schader, SM Zurita, J Teo, E Polonis, V Lu, M Klasse, PJ Moore, JP AF Ketas, Thomas J. Schader, Susan M. Zurita, Juan Teo, Esther Polonis, Victoria Lu, Min Klasse, Per Johan Moore, John P. TI Entry inhibitor-based microbicides are active in vitro against HTV-1 isolates from multiple genetic subtypes SO VIROLOGY LA English DT Article DE HIV-1; microbicide; clades; entry inhibitors; R5 X4 tropism ID IMMUNODEFICIENCY-VIRUS TYPE-1; VAGINAL TRANSMISSION; CXCR4 CORECEPTORS; CCR5 ANTAGONIST; HIV-1 INFECTION; VIRAL DIVERSITY; SCH-C; CELL; NEUTRALIZATION; EPIDEMIOLOGY AB inhibitors of viral entry are under consideration as topical microbicides to prevent HIV-1 sexual transmission. Small molecules targeting HIV-1 gp120 (BMS-378806) or CCR5 (CMPD167), and a peptide fusion inhibitor (C52L), each blocks vaginal infection of macaques by a SHIV. A microbicide, however, must be active against multiple HIV-1 variants. We therefore tested BMS-C (a BMS-378806 derivative), CMPD]67, C52L and the CXCR4 ligand AMD3465, alone and in combination, against 25 primary R5, 12 X4 and 7 R5X4 isolates from subtypes A-G. At high concentrations (0.1 - 1 mu M), the replication of most R5 isolates in human donor lymphocytes was inhibited by > 90%. At lower concentrations, double and triple combinations were more effective than individual inhibitors. Similar results were obtained with X4 viruses when AM D3465 was substituted for CMPD167. The R5X4 viruses were inhibited by combining AMD3465 with CMPD167, or by the coreceptor-independent compounds. Thus, combining entry inhibitors may improve microbicide effectiveness. (c) 2007 Published by Elsevier Inc. C1 Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA. Walter Reed Army Med Ctr, Div Retrovirol, Washington, DC 20307 USA. Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA. RP Moore, JP (reprint author), Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, 1300 York Ave,Box 62, New York, NY 10021 USA. EM jpm2003@med.cornell.edu FU NIAID NIH HHS [U19 AI65413] NR 46 TC 25 Z9 28 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD AUG 1 PY 2007 VL 364 IS 2 BP 431 EP 440 DI 10.1016/j.virol.2007.03.001 PG 10 WC Virology SC Virology GA 181FW UT WOS:000247423500017 PM 17428517 ER PT J AU Bednar, AJ Mirecki, JE Inouye, LS Winfield, LE Larson, SL Ringelberg, DB AF Bednar, A. J. Mirecki, J. E. Inouye, L. S. Winfield, L. E. Larson, S. L. Ringelberg, D. B. TI The determination of tungsten, molybdenum, and phosphorus oxyanions by high performance liquid chromatography inductively coupled plasma mass spectrometery SO TALANTA LA English DT Article; Proceedings Paper CT China-Japan-Korea Symposium on Environmental Analytical Chemistry CY SEP 14-18, 2006 CL Chongqing, PEOPLES R CHINA SP Natl Nat Sci Fdn China, Japanese Soc Anal Chem, Chinese Acad Sci, Shimadzu Beijing Off DE tungstate; molybdate; phosphate; speciation; ICP-MS ID HPLC-ICP-MS; ION CHROMATOGRAPHY; SPECIATION; OXIDASE; SAMPLES; WATER AB The toxic properties of tungsten compounds have recently been brought to the forefront with clusters of human cancer cases, such as in Fallon, NV. Such instances have made the determination of tungsten in natural water supplies vitally important. Tungsten exists in most environmental matrices as the soluble and mobile tungstate anion, although it can polymerize with itself and other anions, such as molybdate and phosphate. Because the geochemical and toxicological properties of these polymer species will vary from the monomeric tungstate parent, determination of tungstate speciation is as critical as determination of total dissolved tungsten concentration. Use of chromatographic separations, followed by element-specific detection is a proven technology for elemental speciation. In the present work, anion exchange chromatography has been coupled to inductively coupled plasma mass spectrometry to determine tungstate, molybdate, and phosphate species at the sub-mu g l(-1) and mu g l(-1) levels. The method provides quantitative determination of these species in about 10 min with the capability to simultaneously determine other oxyanion species. The method has been applied to groundwater and extracts of soils amended with tungsten powder. The water soluble tungsten in 1-h deionized water extracts after six months of soil aging was >15 mg l(-1), however, only similar to 50% of the tungsten was present as monomeric tungstate. (C) 2007 Elsevier B.V. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA. USA, Ctr Res Dev & Engn, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Bednar, AJ (reprint author), USA, Engineer Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Anthony.J.Bednar@erdc.usace.army.mil NR 18 TC 19 Z9 20 U1 2 U2 16 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-9140 J9 TALANTA JI Talanta PD JUL 31 PY 2007 VL 72 IS 5 BP 1828 EP 1832 DI 10.1016/j.talanta.2007.02.016 PG 5 WC Chemistry, Analytical SC Chemistry GA 197BM UT WOS:000248528100037 PM 19071839 ER PT J AU Maples, KR Wheeler, C Ip, E Plattner, JJ Chu, D Zhang, YK Preobrazhenskaya, MN Printsevskaya, SS Solovieva, SE Olsufyeva, EN Heine, H Lovchik, J Lyons, CR AF Maples, Kirk R. Wheeler, Conrad Ip, Emily Plattner, Jacob J. Chu, Daniel Zhang, Yong-Kang Preobrazhenskaya, Maria N. Printsevskaya, Svetlana S. Solovieva, Svetlana E. Olsufyeva, Evgenia N. Heine, Henry Lovchik, Julie Lyons, C. Richard TI Novel semisynthetic derivative of antibiotic eremomycin active against drug-resistant gram-positive pathogens including Bacillus anthracis SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID GLYCOPEPTIDE ANTIBIOTICS; VANCOMYCIN DERIVATIVES; SERIES AB Five adamantyl-containing carboxamides of eremomycin or vancomycin were synthesized and their antibacterial activities against some Gram-positive clinical isolates were investigated in vitro and in vivo. The adamantyl-2 amide of glycopeptide antibiotic eremomycin (1a in Chart 1, AN0900) was the most active compound and showed high activity against several Gram-positive pathogens: vancomycin-susceptible staphylococci and enterococci, glycopeptide-intermediate-resistant Staphylococcus aureus, and glycopeptide-resistant enterococci. Compound 1a was equally active in vitro against both Ciprofloxacin-susceptible and -resistant Bacillus anthracis strains (MICs 0.25-0.5 mu g/mL). It was distinguished by having a 2.8 h half-life (t(1/2)) in mice and a volume of distribution of 2.18 L/kg. Compound 1a was active against Staphylococcus aureus in mice (iv) and provided complete protection against a lethal intravenous challenge with vegetative B. anthracis bacilli and also in a murine pulmonary anthrax model in which mice were challenged with Bacillus anthracis spores. C1 Anacor Pharmaceut Inc, Palo Alto, CA 94303 USA. Galileo Pharmaceut Inc, Santa Clara, CA 95054 USA. Gause INst New Antibiot, Moscow 119021, Russia. USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. Univ New Mexico, Hlth Sci Ctr, BMSB G41, MSC10 5550, Albuquerque, NM 87131 USA. RP Preobrazhenskaya, MN (reprint author), Anacor Pharmaceut Inc, 1060 E Meadow Circle, Palo Alto, CA 94303 USA. EM mnp@space.ru OI Olsufyeva, Evgenia/0000-0002-2598-913X; Preobrazhenskaya, Maria/0000-0001-9782-1101 NR 15 TC 10 Z9 12 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUL 26 PY 2007 VL 50 IS 15 BP 3681 EP 3685 DI 10.1021/jm0700058 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 191HD UT WOS:000248121300030 PM 17608397 ER PT J AU Hammamieh, R Sumaida, D Zhang, XY Das, R Jett, M AF Hammamieh, Rasha Sumaida, Dena Zhang, XiaoYan Das, Rina Jett, Marti TI Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism SO BMC CANCER LA English DT Article ID PANCREATIC PHOSPHOLIPASE A(2); EICOSANOID METABOLISM; ACID METABOLISM; LINE; INHIBITORS; PROLIFERATION; LEUKOTRIENES; EXPRESSION; APOPTOSIS; CURCUMIN AB Background: Arachidonate metabolites are important regulators of human breast cancer cells. Production of bioactive lipids are frequently initiated by the enzyme phospholipase A2 which releases arachidonic acid (AA) that is rapidly metabolized by cyclooxygenases (COX) or lipoxygenases (LO) to other highly potent lipids. Methods: In this study we screened a number of inhibitors which blocked specific pathways of AA metabolism for their antiproliferative activity on MCF-7 wild type and MCF-7 ADR drug resistant breast cancer cells. The toxicity of these inhibitors was further tested on human bone marrow cell proliferation. Results: Inhibitors of LO pathways (specifically the 5-LO pathway) were most effective in blocking proliferation. Inhibitors of platelet activating factor, a byproduct of arachidonate release, were also effective antiproliferative agents. Curcumin, an inhibitor of both COX and LO pathways of eicosanoid metabolism, was 12-fold more effective in blocking proliferation of the MCF-7 ADRs cells compared to MCF-7 wild type (WT) cells. These inhibitors that effectively blocked the proliferation of breast cancer cells showed varying degrees of toxicity to cultures of human bone marrow cells. We observed greater toxicity to bone marrow cells with inhibitors that interfere with the utilization of AA in contrast to those which block utilization of its downstream metabolites. MK-591, MK-886, PCA-4248, and AA-861 blocked proliferation of breast cancer cells but showed no toxicity to bone marrow cells. Conclusion: These inhibitors were effective in blocking the proliferation of breast cancer cells and may be potentially useful in human breast cancer therapy. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. EM rasha.hammamieh@na.amedd.army.mil; dena.sumaida@us.army.mil; xiaoyan.zhang@na.amedd.army.mil; dasr2@nhlbi.nih.gov; marti.jett@us.army.mil NR 27 TC 24 Z9 28 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2407 J9 BMC CANCER JI BMC Cancer PD JUL 25 PY 2007 VL 7 AR 138 DI 10.1186/1471-2407-7-138 PG 9 WC Oncology SC Oncology GA 199PN UT WOS:000248707800001 PM 17651499 ER PT J AU Snyder, JF Carter, RH Wetzel, ED AF Snyder, James F. Carter, Robert H. Wetzel, Eric D. TI Electrochemical and mechanical behavior in mechanically robust solid polymer electrolytes for use in multifunctional structural batteries SO CHEMISTRY OF MATERIALS LA English DT Article ID IONIC-CONDUCTIVITY; LITHIUM BATTERIES; COPOLYMER ELECTROLYTES; POLY(ETHYLENE OXIDE); COMB POLYMERS; SIDE-CHAINS; NETWORKS; STATE; COMPOSITES; SYSTEMS AB Polymer electrolytes were investigated for potential use in multifunctional structural batteries requiring both mechanical and electrochemical properties. Electrolytes were formulated with a broad range of multifunctional behaviors, spanning continuously from highly conductive and structurally weak materials to poorly conductive and highly structural materials. Solvent-free polymer scaffolds were synthesized from monomers containing poly( ethylene glycol) ( PEG) oligomers and one to four vinyl ester groups. The electrolytes were formed by dissolving lithium trifluoromethanesulfonate in the monomers prior to thermal cure. Electrochemical, mechanical, and viscoelastic properties were studied with respect to salt concentration, polymer chemistry, and polymer architecture. The addition of salt was found to have minimal impact on compressive stiffness, whereas it increased Tg and significantly influenced ion conductivity, with a maximum conductivity at 9-12% salt w/w PEG. At a constant salt concentration, the homopolymer electrolytes exhibited close to a 1: 1 inverse correlation between conductivity and stiffness as monomer composition was changed. C1 USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Snyder, JF (reprint author), USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. EM jsnyder@arl.army.mil NR 38 TC 58 Z9 58 U1 7 U2 55 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD JUL 24 PY 2007 VL 19 IS 15 BP 3793 EP 3801 DI 10.1021/cm070213o PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 190QF UT WOS:000248073300036 ER PT J AU Dutta, S Lee, SY Batchelor, AH Lanar, DE AF Dutta, Sheetij Lee, Seung Yeon Batchelor, Adrian H. Lanar, David E. TI Structural basis of antigenic escape of a malaria vaccine candidate SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE Plasmodium; apical membrane antigen-1; invasion ID APICAL MEMBRANE ANTIGEN-1; BLOOD-STAGE MALARIA; PLASMODIUM-FALCIPARUM; IN-VITRO; ANTIBODY; AMA1; PROTECTION; RESPONSES; IMMUNOGENICITY; POLYMORPHISMS AB Antibodies against the malaria vaccine candidate apical membrane antigen-1 (AMA-1) can inhibit invasion of merozoites into RBC, but antigenic diversity can compromise vaccine efficacy. We hypothesize that polymorphic sites located within inhibitory epitopes function as antigenic escape residues (AER). By using an in vitro model of antigenic escape, the inhibitory contribution of 24 polymorphic sites of the 3D7 AMA-1 vaccine was determined. An AER cluster of 13 polymorphisms, located within domain 1, had the highest inhibitory contribution. Within this AER cluster, antibodies primarily targeted five polymorphic residues situated on an ahelical loop. A second important AER cluster was localized to domain 2. Domain 3 polymorphisms enhanced the inhibitory contribution of the domain 2 AER cluster. Importantly, the AER clusters could be split, such that chimeras containing domain 1 of FVO and domain 2 + 3 of 3D7 generated antisera that showed similarly high level inhibition of the two vaccine strains. Antibodies to this chimeric protein also inhibited unrelated strains of the parasite. Interstrain AER chimeras can be a way to incorporate inhibitory epitopes of two AMA-1 strains into a single protein. The AER clusters map in close proximity to conserved structural elements: the hydrophobic trough and the C-terminal proteolytic processing site. This finding led us to hypothesize that a conserved structural basis of antigenic escape from anti-AMA-1 exists. Genotyping high-impact AER may be useful for classifying AMA-1 strains into inhibition groups and to detect allelic effects of an AMA-1 vaccine in the field. C1 Walter Reed Army Inst Res, Dept Epitope Mapping, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. Univ Baltimore, Sch Pharm, Baltimore, MD 21201 USA. RP Dutta, S (reprint author), Walter Reed Army Inst Res, Dept Epitope Mapping, Silver Spring, MD 20910 USA. EM sheetij.dutta@na.amedd.army.mil RI Lanar, David/B-3560-2011 NR 28 TC 77 Z9 79 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUL 24 PY 2007 VL 104 IS 30 BP 12488 EP 12493 DI 10.1073/pnas.0701464104 PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA 196HK UT WOS:000248472100047 PM 17636123 ER PT J AU Krapels, K Driggers, RG Jacobs, E Burks, S Young, S AF Krapels, Keith Driggers, Ronald G. Jacobs, Eddie Burks, Stephen Young, Susan TI Characteristics of infrared imaging systems that benefit from superresolution reconstruction SO APPLIED OPTICS LA English DT Article ID RESOLUTION ENHANCEMENT; TEMPORAL ACCUMULATION; PERFORMANCE; IMAGERS; VIDEO; TOD AB There have been numerous applications of superresolution reconstruction algorithms to improve the range performance of infrared imagers. These studies show there can be a dramatic improvement in range performance when superresolution algorithms are applied to undersampled imager outputs. These occur when the imager is moving relative to the target, which creates different spatial samplings of the field of view for each frame. The degree of performance benefit is dependent on the relative sizes of the detector/spacing and the optical blur spot in focal plane space. The minimum blur spot size achievable on the focal plane is dependent on the system F/number. Hence, we provide a range of these sensor characteristics, for which there is a benefit from superresolution reconstruction algorithms. Additionally, we quantify the potential performance improvements associated with these algorithms. We also provide three infrared sensor examples to show the range of improvements associated with provided guidelines. (c) 2007 Optical Society of America. C1 Off Naval Res, Arlington, VA 22203 USA. US Army Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA. Army Res Lab, Adelphi, MD 20783 USA. RP Krapels, K (reprint author), Off Naval Res, 875 N Randolph St, Arlington, VA 22203 USA. EM krapelk@onr.navy.mil NR 22 TC 10 Z9 11 U1 1 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 2007 VL 46 IS 21 BP 4594 EP 4603 DI 10.1364/AO.46.004594 PG 10 WC Optics SC Optics GA 191NR UT WOS:000248138500009 PM 17609705 ER PT J AU Kester, KE McKinney, DA Tornieporth, N Ockenhouse, CF Heppner, DG Hall, T Wellde, BT White, K Sun, P Schwenk, R Krzych, U Delchambre, M Voss, G Dubois, MC Gasser, RA Dowler, MG O'Brien, M Wittes, J Wirtz, R Cohen, J Ballou, WR AF Kester, Kent E. McKinney, Denise A. Tornieporth, Nadia Ockenhouse, Christian F. Heppner, D. Gray, Jr. Hall, Ted Wellde, Bruce T. White, Kate Sun, Peifang Schwenk, Robert Krzych, Urszula Delchambre, Martine Voss, Gerald Dubois, Marie-Claude Gasser, Robert A., Jr. Dowler, Megan G. O'Brien, Megan Wittes, Janet Wirtz, Robert Cohen, Joe Ballou, W. Ripley CA RTS,S Malaria Vaccine Evaluation G TI A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naive adults SO VACCINE LA English DT Article DE RTS,S; malaria; vaccine; falciparum; Plasmodium; antigens; adjuvant; clinical trials; AS02A; circumsporozoite protein ID PLASMODIUM-FALCIPARUM MALARIA; CIRCUMSPOROZOITE PROTEIN VACCINE; CONTROLLED-TRIAL; CHILDREN; IMMUNIZATION; INFECTION; RESPONSES; DISEASE; ANTIGEN; GAMBIA AB We conducted an open-label safety and immunogenicity bridging study that compared liquid and lyophilized formulations of the candidate malaria vaccine RTS,S formulated in AS02A in 34 healthy, malaria-naive adults at WRAIR. Volunteers received two doses of either formulation. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. GlaxoSmithKline Biol, Rixensart, Belgium. Stat Collaborat Inc, Washington, DC USA. Ctr Dis Control & Prevent, Atlanta, GA USA. RP Kester, KE (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM kent.kester@na.amedd.army.mil RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 24 TC 62 Z9 63 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD JUL 20 PY 2007 VL 25 IS 29 BP 5359 EP 5366 DI 10.1016/j.vaccine.2007.05.005 PG 8 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 194QQ UT WOS:000248359300019 PM 17574311 ER PT J AU Guneralp, B Gertner, G Mendoza, G Anderson, A AF Guneralp, Burak Gertner, George Mendoza, Guillermo Anderson, Alan TI Evaluating probabilistic data with a possibilistic criterion in land-restoration decision-making: Effects on the precision of results SO FUZZY SETS AND SYSTEMS LA English DT Article DE decision analysis; measures of information; land restoration; geography; uncertainty; entropy; vagueness ID SOIL LOSS EQUATION; FUZZY-SETS; UNCERTAINTY; ENTROPY; FUZZINESS AB Many decision-making settings incorporate both possibilistic and probabilistic uncertainty. In this study, entropy is used as a common measure in quantifying both types of uncertainty. This measure facilitates the direct comparison of the "amounts" of the two types of uncertainty in a given situation. The main objective of this study is, however, to illustrate how, in a decision-making setting, incorporating fuzzy membership function to represent possibilistic uncertainty leads to a more realistic assessment of the decision-making problem at hand. A methodology for the evaluation of land condition and for aiding the decision on restoration allocation and a case study is presented. The methodology enables handling both types of uncertainty: probabilistic uncertainty from the spatial simulation data and possibilistic uncertainty due to vagueness in land condition factor. Erosion status is selected as the land condition factor. Restoration allocation decision is based on fuzzy logic to reflect the continuous transition between different land conditions. The analysis is done six times, each time using a membership function with a different degree of fuzziness. Insights gathered from this study would relate to the risks associated with taking a decision in the presence of both types of uncertainty. The comparison of the output of the analysis (i.e. the loss associated with misclassification) from six different trials reveals that the variance in the loss values decreases as more fuzziness is incorporated into the analysis. In other words, there is an inverse relation between the coefficient of variance of the loss values and the fuzziness incorporated into the analysis. A more in-depth analytical investigation is needed to understand if this observation is specific to this case study or a more general phenomenon. (c) 2007 Elsevier B.V. All rights reserved. C1 Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA. US ACE, CERL, Champaign, IL USA. RP Guneralp, B (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, W503 Turner Hall,1102 S Goodwin Ave, Urbana, IL 61801 USA. EM guneralp@stanford.edu NR 27 TC 2 Z9 2 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0114 J9 FUZZY SET SYST JI Fuzzy Sets Syst. PD JUL 16 PY 2007 VL 158 IS 14 BP 1546 EP 1560 DI 10.1016/j.fss.2007.02.021 PG 15 WC Computer Science, Theory & Methods; Mathematics, Applied; Statistics & Probability SC Computer Science; Mathematics GA 181AW UT WOS:000247410100003 ER PT J AU Hurst, C AF Hurst, Cindy TI Investment risky in Russia as politics affects profits SO OIL & GAS JOURNAL LA English DT Article C1 USA, Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA. RP Hurst, C (reprint author), USA, Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU PENNWELL PUBL CO ENERGY GROUP PI TULSA PA 1421 S SHERIDAN RD PO BOX 1260, TULSA, OK 74112 USA SN 0030-1388 J9 OIL GAS J JI Oil Gas J. PD JUL 16 PY 2007 VL 105 IS 27 BP 18 EP + PG 6 WC Energy & Fuels; Engineering, Petroleum SC Energy & Fuels; Engineering GA 194FT UT WOS:000248330500005 ER PT J AU Purcell, AL Hoard-Fruchey, HM AF Purcell, Angela L. Hoard-Fruchey, Heidi M. TI A capillary electrophoresis method to assay catalytic activity of botulinum neurotoxin serotypes: Implications for substrate specificity SO ANALYTICAL BIOCHEMISTRY LA English DT Article DE botulinum neurotoxin; capillary electrophoresis; catalytic activity; enzyme assay; serotypes ID LIGHT-CHAIN; PROTEASE ACTIVITIES; MASS-SPECTROMETRY; MEMBRANE-PROTEIN; SNARE MOTIF; RECOGNITION; PROTEOLYSIS; TOXIN; IDENTIFICATION; INHIBITOR AB The potent botulinum neurotoxin inhibits neurotransmitter release at cholinergic nerve terminals, causing a descending flaccid paralysis characteristic of the disease botulism. The currently expanding medical use of the neurotoxin to treat several disorders, as well as the potential misuse of the neurotoxin as an agent in biowarfare, has made understanding of the nature of the toxin's catalytic activity and development of inhibitors critical. To study the catalytic activity of botulinum neurotoxin more thoroughly and characterize potential inhibitors, we have developed a capillary electrophoresis method to measure catalytic activity of different serotypes of botulinum neurotoxin using peptides derived from the native substrates. This assay requires only a minute amount of sample (25 nl), is relatively rapid (15 min/sample), and allows the determination of enzyme kinetic constants for a more sophisticated characterization of inhibitors and neurotoxin catalytic activity. Using this method, we can measure activity of five of the seven serotypes of botulinum neurotoxin (A, B, E, F, and G) with two peptide substrates. Botulinum neurotoxin serotypes C and D did not cleave our pepticles, lending insight into potential substrate requirements among the serotypes. (c) 2007 Elsevier Inc. All rights reserved. C1 USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA. USA, Med Res Inst Chem Def, Comparat Pathol Branch, Div Comparat Med, Aberdeen Proving Ground, MD 21010 USA. RP Purcell, AL (reprint author), USA, Med Res Inst Chem Def, Neurobehav Toxicol Branch, Div Analyt Toxicol, Aberdeen Proving Ground, MD 21010 USA. EM angela.purcell1@us.army.mil NR 40 TC 14 Z9 15 U1 0 U2 5 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD JUL 15 PY 2007 VL 366 IS 2 BP 207 EP 217 DI 10.1016/j.ab.2007.04.048 PG 11 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA 187QL UT WOS:000247863000013 PM 17548044 ER PT J AU Farley, J Risinger, JI Rose, GS Maxwell, GL AF Farley, John Risinger, John I. Rose, G. Scoff Maxwell, G. Larry TI Racial disparities in blacks with gynecologic cancers SO CANCER LA English DT Article DE race; gynecologic; malignancies; outcome ID AFRICAN-AMERICAN WOMEN; EPITHELIAL OVARIAN-CANCER; DATA-BASE REPORT; UNITED-STATES; ENDOMETRIAL CANCER; CERVICAL-CANCER; WHITE WOMEN; PHYSICAL-ACTIVITY; BRCA2 MUTATIONS; CARCINOMA AB Black women have a lower incidence of gynecologic cancers but they have a higher mortality associated with their disease. The etiology of the racial disparity in outcome among gynecologic cancer patients is multifactoral and site-specific. Black women with endometrial cancer often present with more advanced stage tumors that are associated with a worse prognosis compared with White women. Evidence suggests that observed disparities in outcome are due to inequalities in treatment or differing biologic etiologies. For cervix cancer, studies have suggested that survival among Black women may be lower than survival among White women that develop this disease. This occurs despite evidence that indicates that Pap smears are utilized similarly by Black and White women for cervix cancer screening. These differences in outcome may become less pronounced 3 when comorbidities are accounted for and inequalities in treatment are eliminated. For ovarian cancer patients, survival has improved with the use of contemporary therapies over the past 30 years in Whites but less so for Blacks. This may be due to differences in the likelihood of primary surgical cytoreductions, which are performed less frequently in some Black women because of extensive metastatic spread or comorbidities. The observed decreases in survival for all 3 gynecologic cancers potentially may be affected by socioeconomic status of the patient in some healthcare settings. An improved understanding of the causative factors associated with racial disparities in gynecologic cancer outcome is necessary to facilitate efforts aimed at correcting this important healthcare problem. C1 Walter Reed Army Med Ctr, Gynecol Dis Ctr, Washington, DC 20307 USA. Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. Mem Hlth Univ Med Ctr, Dept Lab Oncol Res, Curtis & Elizabeth Anderson Canc Inst, Savannah, GA USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Gynecol Dis Ctr, Bldg 2,Room 2J06,6900 Georgia Ave NW, Washington, DC 20307 USA. EM george.maxwell@na.amedd.army.mil NR 63 TC 33 Z9 33 U1 0 U2 4 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0008-543X J9 CANCER JI Cancer PD JUL 15 PY 2007 VL 110 IS 2 BP 234 EP 243 DI 10.1002/cncr.22797 PG 10 WC Oncology SC Oncology GA 189JQ UT WOS:000247985600002 PM 17559136 ER PT J AU Neutzner, M Lopez, T Feng, X Bergmann-Leitner, ES Leitner, WW Udey, MC AF Neutzner, Melanie Lopez, Theresa Feng, Xu Bergmann-Leitner, Elke S. Leitner, Wolfgancr W. Udey, Mark C. TI MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis SO CANCER RESEARCH LA English DT Article ID DEVELOPMENTAL ENDOTHELIAL LOCUS-1; BETA-CELL CARCINOGENESIS; APOPTOTIC CELLS; INTEGRIN; MICE; RECEPTOR; PROTEIN; NEOVASCULARIZATION; ALPHA-V-BETA-3; IDENTIFICATION AB The relevance of angiogenesis in tumor biology and as a therapeutic target is well established. MFG-E8 (also termed lactadherin) and developmental endothelial locus 1 (Del1) constitute a two-gene family of alpha(v)beta(3)/beta(5) ligands that regulate angiogenesis. After detecting MFG-E8 mWNA in murine tumor cell lines, we sought to determine if MFG-ES influenced tumorigenesis in Rip1-Tag2 transgenic mice, a cancer model in which angiogenesis is critical. MFG-E8 mRNA and protein were increased in angiogenic islets and tumors in Rip1-Tag2 mice compared with normal pancreas. Frequencies of angiogenic islets and tumor burdens were decreased in MFGE8-deficient Rip1-Tag2 mice compared with those in control Rip1-Tag2 mice. Invasive carcinomas were modestly under-represented in MFG-E8-deficient mice, but tumor frequencies and survivals were comparable in these two strains. Absence of MFG-E8 also led to decreases in tumor vascular permeability without obvious changes in vascular morphology. Decreased proliferation was noted in angiogenic islets and increases in apoptotic cells were detected in islets and tumors. Compensaton increases in mmRNA encoding proangiogenic proteins, including FGF2, in angiogenic islets, and Dell, in angiogenic islets and tumors, were also detected in MFG-E8-deficient mice. MFG-ES and its homologue Dell may represent relevant targets in cancer and other diseases in which angiogenesis is prominent. C1 NCI, Dermatol Branch, Canc Res Ctr, Dermatol Branch,NIH, Bethesda, MD 20892 USA. NCI, Dermatol Branch, Canc Res Ctr, Basic Res Lab,NIH, Bethesda, MD 20892 USA. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD USA. RP Udey, MC (reprint author), NCI, Dermatol Branch, Canc Res Ctr, Dermatol Branch,NIH, Bldg 10,Room 12N238, Bethesda, MD 20892 USA. EM udey@helix.nih.gov RI Bergmann-Leitner, Elke/B-3548-2011; Leitner, Wolfgang/F-5741-2011 OI Bergmann-Leitner, Elke/0000-0002-8571-8956; Leitner, Wolfgang/0000-0003-3125-5922 FU Intramural NIH HHS NR 32 TC 49 Z9 51 U1 0 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JUL 15 PY 2007 VL 67 IS 14 BP 6777 EP 6785 DI 10.1158/0008-5472.CAN-07-0165 PG 9 WC Oncology SC Oncology GA 194BN UT WOS:000248319000032 PM 17638889 ER PT J AU Halder, R Lawal, A Damavarapu, R AF Halder, Raghunath Lawal, Adeniyi Damavarapu, Reddy TI Nitration of toluene in a microreactor SO CATALYSIS TODAY LA English DT Article; Proceedings Paper CT Topical Conference on Applications of Micro-Reactor Engineering held at the AIChE Spring Conference CY APR 23-27, 2006 CL Orlando, FL SP Amer Inst Chem Engineers DE nitration; microreactor; nitric acid; nitrotoluene ID MACROKINETICS; REACTOR; ACIDS AB Highly exothermic reactions such as aromatic nitration can be carried out in a highly efficient manner in microreactors due to the high heat and mass transfer rates in such reactors. In this study, nitration of toluene was conducted in a microreactor immersed in a constant temperature bath using concentrated nitric acid as the nitrating agent. The effects of residence time, reaction temperature, and acid concentration, etc., on the reactor performance were studied. The results indicate that in the microreactor the nitration reaction proceeds rapidly, even without sulfuric acid, probably by self-protonation of nitric acid. Also, no by-products were detected. The isomeric distribution of the product nitrotoluenes was found to be identical to that generally found in the mixed-acid nitration. The results were compared with the data obtained from a batch reactor, and the microreactor reaction rates were found to be much higher than the batch reactor rates. (c) 2007 Elsevier B.V. All rights reserved. C1 Stevens Inst Technol, Dept Chem Biomed & Mat Engn, New Jersey Ctr Microchem Syst, Hoboken, NJ 07030 USA. USA, Dev & Engn Ctr, Armament Res, Energet & Warheads Div, Picatinny Arsenal, NJ USA. RP Halder, R (reprint author), Stevens Inst Technol, Dept Chem Biomed & Mat Engn, New Jersey Ctr Microchem Syst, Castle Point, Hoboken, NJ 07030 USA. EM rhalder@stevens.edu NR 18 TC 33 Z9 38 U1 5 U2 33 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-5861 J9 CATAL TODAY JI Catal. Today PD JUL 15 PY 2007 VL 125 IS 1-2 BP 74 EP 80 DI 10.1016/j.cattod.2007.04.002 PG 7 WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical SC Chemistry; Engineering GA 195JR UT WOS:000248409000012 ER PT J AU Emamipour, H Hashisho, Z Cevallos, D Rood, MJ Thurston, DL Hay, KJ Kim, BJ Sullivan, PD AF Emamipour, Hamidreza Hashisho, Zaher Cevallos, Diego Rood, Mark J. Thurston, Deborah L. Hay, K. James Kim, Byung J. Sullivan, Patrick D. TI Steady-state and dynamic desorption of organic vapor from activated carbon with electrothermal swing adsorption SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID FIBER CLOTH; PERFORMANCE; BIOFILTER; MIXTURES; PERIODS; NONUSE AB A now method to achieve steady-state and dynamic-tracking desorption of organic compounds from activated carbon was developed and tested with a bench-scale system. Activated carbon fiber cloth (ACFC) was used to adsorb methyl ethyl ketone (MEK) from air streams. Direct electrothermal heating was then used to desorb the vapor to generate select vapor concentrations at 500 ppmv and 5000 ppmv in air. Dynamic-tracking desorption was also achieved with carefully controlled yet variable vapor concentrations between 250 ppmv and 5000 ppmv, while also allowing the flow rate of the carrier gas to change by 100%. These results were also compared to conditions when recovering MEK as a liquid, and using microwaves as the source of energy to regenerate the adsorbent to provide MEK as a vapor or a liquid. C1 Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. Univ Illinois, Ind & Enterprise Syst Engn, Urbana, IL 61801 USA. Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. USAF, Res Lab MLQL, Tyndall AFB, FL 32403 USA. RP Rood, MJ (reprint author), Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. EM mrood@uiuc.edu NR 18 TC 21 Z9 22 U1 1 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL 15 PY 2007 VL 41 IS 14 BP 5063 EP 5069 DI 10.1021/es0703022 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA 194SC UT WOS:000248363100040 PM 17711224 ER PT J AU Bhosle, V Prater, JT Yang, F Burk, D Forrest, SR Narayan, J AF Bhosle, V. Prater, J. T. Yang, Fan Burk, D. Forrest, S. R. Narayan, J. TI Gallium-doped zinc oxide films as transparent electrodes for organic solar cell applications SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID LIGHT-EMITTING DEVICES; WINDOWS AB We report microstructural characteristics and properties of gallium-doped ZnO films deposited on glass by pulsed laser deposition. The Zn0.95Ga0.05O film deposited at 200 degrees C and 1x10(-3) Torr showed predominant < 0001 > orientation with a metallic behavior and a resistivity of 2x10(-4) Omega cm at room temperature. Low resistivity of the ZnGaO films has been explained in terms of optimal combination of carrier concentration and minimized scattering, and is correlated with the microstructure and the deposition parameters. Power conversion efficiency comparable to indium tin oxide-based devices (1.25 +/- 0.05%) is achieved on a Zn0.95Ga0.05O/Cu-phthalocyanine/C-60 double-heterojunction solar cell. (c) 2007 American Institute of Physics. C1 N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. USA, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA. Princeton Univ, Princeton Inst Sci & Technol Mat PRISM, Princeton, NJ 08544 USA. Princeton Univ, Dept Elect Engn, Princeton, NJ 08544 USA. Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA. Univ Michigan, Dept Phys, Ann Arbor, MI 48109 USA. RP Bhosle, V (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA. EM vmbhosle@ncsu.edu RI Narayan, Jagdish/D-1874-2009 NR 23 TC 85 Z9 85 U1 0 U2 30 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 2007 VL 102 IS 2 AR 023501 DI 10.1063/1.2750410 PG 5 WC Physics, Applied SC Physics GA 196MD UT WOS:000248485100019 ER PT J AU Karrea, PSK Bergstrom, PL Mallick, G Karna, SP AF Karrea, P. Santosh Kumar Bergstrom, Paul L. Mallick, Govind Karna, Shashi P. TI Room temperature operational single electron transistor fabricated by focused ion beam deposition SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID TUNNEL-JUNCTIONS; THERMOMETRY; DEVICES; ARRAYS; ISLAND AB We present the fabrication and room temperature operation of single electron transistors using 8 nm tungsten islands deposited by focused ion beam deposition technique. The tunnel junctions are fabricated using oxidation of tungsten in peracetic acid. Clear Coulomb oscillations, showing charging and discharging of the nanoislands, are seen at room temperature. The device consists of an array of tunnel junctions; the tunnel resistance of individual tunnel junction of the device is calculated to be as high as 25.13 G Omega. The effective capacitance of the array of tunnel junctions was found to be 0.499 aF, giving a charging energy of 160.6 meV. C1 Michigan Technol Univ, Multi Scale Technol Inst, Houghton, MI 49931 USA. Michigan Technol Univ, Dept Elect & Comp Engn, Houghton, MI 49931 USA. USA, Ballist Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Karrea, PSK (reprint author), Michigan Technol Univ, Multi Scale Technol Inst, Houghton, MI 49931 USA. EM pskarre@mtu.edu NR 19 TC 16 Z9 16 U1 0 U2 7 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 2007 VL 102 IS 2 AR 024316 DI 10.1063/1.2761837 PG 4 WC Physics, Applied SC Physics GA 196MD UT WOS:000248485100102 ER PT J AU Patel, AA Vaccaro, AR Martyak, GG Harrop, JS Albert, TJ Ludwig, SC Youssef, JA Gelb, DE Mathews, HH Chapman, JR Chung, EH Grabowski, G Kuklo, TR Hilibrand, AS Anderson, DG AF Patel, Alpesh A. Vaccaro, Alexander R. Martyak, Gregg G. Harrop, James S. Albert, Todd J. Ludwig, Steven C. Youssef, Jim A. Gelb, Daniel E. Mathews, Hallett H. Chapman, Jens R. Chung, Edward H. Grabowski, Gregory Kuklo, Timothy R. Hilibrand, Alan S. Anderson, D. Greg TI Neurologic deficit following percutaneous vertebral stabilization SO SPINE LA English DT Article DE vertebroplasty; kyphoplasty; complications; paralysis; paresis ID OSTEOPOROTIC COMPRESSION FRACTURES; CEMENT LEAKAGE; VERTEBROPLASTY; KYPHOPLASTY; POLYMETHYLMETHACRYLATE; SPINE; METHACRYLATE; MANAGEMENT; OUTCOMES; MYELOMA AB Study Design. A retrospective review. Objective. The purpose of this study is to document a series of cases of neurologic deficit following percutaneous vertebral stabilization, to identify patterns of neurologic injury, and to describe potential methods for avoiding these injuries. Summary of Background Data. Percutaneous vertebral stabilization procedures, including vertebroplasty and kyphoplasty, have become a widely used for the treatment of osteoporotic vertebral compression fractures, primary and metastatic vertebral tumors, and traumatic burst fractures. Despite an increasing array of indications, there have been few reports of adverse events. Neurologic complications associated with vertebroplasty and kyphoplasty have been described previously as case reports and have generally been considered as infrequent and minor in severity. Methods. The clinical course of 14 patients with documented loss of neurologic function following percutaneous vertebral cement augmentation was retrospectively reviewed. Results. The average patient age was 74.9 years (range, 46-88 years) with 3 male and 11 female patients. Four patients underwent a vertebroplasty procedure while 10 were treated with kyphoplasty. Six patients developed neurologic deficits acutely (< 24 hours of procedure). The remaining 8 patients developed neurologic symptoms at an average of 37.1 days (range, 3-112 days) C1 Univ Utah, Dept Orthopaed Surg, Salt Lake City, UT 84108 USA. Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. Thomas Jefferson Univ, Dept Neurosurg, Philadelphia, PA 19107 USA. Univ Maryland, Dept Orthopaed Surg, College Pk, MD 20742 USA. R Cowley Adams Shock Trauma, Baltimore, MD USA. Durango Orthopaed Associates, Durango, CO USA. Virginia Commonwealth Univ, Med Coll Virginia, Dept Orthopaed Surg, Richmond, VA 23298 USA. Univ Washington, Dept Orthopaed Surg, Seattle, WA 98195 USA. Walter Reed Army Med Ctr, Dept Orthopaed Surg & Rehabilitat, Washington, DC 20307 USA. RP Patel, AA (reprint author), Univ Utah, Dept Orthopaed Surg, 590 Wakara Way, Salt Lake City, UT 84108 USA. EM alpesh2@gmail.com NR 35 TC 40 Z9 48 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD JUL 15 PY 2007 VL 32 IS 16 BP 1728 EP 1734 DI 10.1097/BRS.0b013e3180dc9c36 PG 7 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 191BY UT WOS:000248106000006 PM 17632393 ER PT J AU Taillandier, AS Domine, F Simpson, WR Sturm, M Douglas, TA AF Taillandier, Anne-Sophie Domine, Florent Simpson, William R. Sturm, Matthew Douglas, Thomas A. TI Rate of decrease of the specific surface area of dry snow: Isothermal and temperature gradient conditions SO JOURNAL OF GEOPHYSICAL RESEARCH-EARTH SURFACE LA English DT Article ID SCANNING-ELECTRON-MICROSCOPY; ALERT 2000 CAMPAIGN; SUB-ARCTIC SNOW; GRAIN-GROWTH; 77 K; METAMORPHISM; EVOLUTION; ADSORPTION; COVER; TRENDS AB The specific surface area (SSA) of snow is the surface area available to gases per unit mass. It is an important variable for quantifying air- snow exchange of chemical species, and it is closely related to other variables such as albedo. Snow SSA decreases during metamorphism, but few data are available to quantify its rate of decrease. We have performed laboratory experiments under isothermal and temperature gradient conditions during which the SSA of snow samples was monitored for several months. We have also monitored the SSA of snowfalls subjected to large temperature gradients at a field site in the central Alaskan taiga. The same snow layers were also monitored in a manipulated snowpack where the temperature gradient was greatly reduced. In all cases, the SSA decay follows a logarithmic equation with three adjustable variables that are parameterized using the initial snow SSA and the time- averaged temperature of the snow. Two parameterizations of the three adjustable variables are found: One applies to the isothermal experiments and to the quasi- isothermal cases studied in Alaska ( equitemperature ( ET) metamorphism), and the other is applicable to both the laboratory experiments performed under temperature gradients and to the natural snowpack in Alaska ( temperature gradient ( TG) metamorphism). Higher temperatures accelerate the decrease in SSA, and this decrease is faster under TG than ET conditions. We discuss the conditions of applicability of these parameterizations and use them to speculate on the effect of climate change on snow SSA. Depending on the climate regime, changes in the rate of decay of snow SSA and hence in snow albedo may produce either negative or positive feedbacks on climate change. C1 CNRS, Lab Glaciol & Geophys Environm, St Martin Dheres, France. Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA. Univ Alaska Fairbanks, Dept Chem, Fairbanks, AK USA. US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK USA. RP Taillandier, AS (reprint author), CNRS, Lab Glaciol & Geophys Environm, St Martin Dheres, France. RI Domine, Florent/E-8699-2011; Simpson, William/I-2859-2014 OI Simpson, William/0000-0002-8596-7290 NR 37 TC 38 Z9 38 U1 0 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9003 EI 2169-9011 J9 J GEOPHYS RES-EARTH JI J. Geophys. Res.-Earth Surf. PD JUL 14 PY 2007 VL 112 IS F3 AR F03003 DI 10.1029/2006JF000514 PG 13 WC Geosciences, Multidisciplinary SC Geology GA 190BA UT WOS:000248031500001 ER PT J AU Solares, SD Crone, JC AF Solares, Santiago D. Crone, Joshua C. TI Real-time simulation of isolated biomolecule characterization with frequency and force modulation atomic force microscopy SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID CARBON-NANOTUBE TIPS; SAMPLE INTERACTION REGIMES; SCANNING PROBE MICROSCOPY; AMPLITUDE-MODULATION; MOLECULAR-DYNAMICS; RESOLUTION; BISTABILITY; CAPILLARY; MEMBRANES; SURFACES AB Recently a new AFM technique, frequency and force modulation AFM (FFM-AFM), was proposed for the characterization of delicate samples and applied within numerical simulations to calculate the cross-sectional scan of a single bacteriorhodopsin molecule with a carbon nanotube probe in air. A real-time imaging simulation of the same molecule and probe is presented here, illustrating the effect of horizontal scan speed, cantilever stiffness, effective frequency setpoint, and quality factor on the images obtained. Controls parameters are proposed for scan speeds of similar to 150 and similar to 25 nm/s in air and water, respectively. The results indicate that the most common causes leading to distorted images are excessive sample compression and denting by the tip when it approaches the sample horizontally, and loss of contact with the surface as the tip continues traveling horizontally past the sample, both of which can occur for high scan speeds and large cantilever force constants. The calculations also show that imaging conditions can be found for which the tip-sample repulsive forces and sample deformation are small and depend only weakly on imaging parameters other than scan speed. C1 Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Solares, SD (reprint author), Univ Maryland, Dept Mech Engn, College Pk, MD 20742 USA. EM ssolares@umd.edu NR 36 TC 18 Z9 18 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD JUL 12 PY 2007 VL 111 IS 27 BP 10029 EP 10034 DI 10.1021/jp0718350 PG 6 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 186EN UT WOS:000247762000050 ER PT J AU Sanchez, A Cheung, KF AF Sanchez, Alejandro Cheung, Kwok Fai TI Tsunami forecast using an adaptive inverse algorithm for the Peru-Chile source region SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID EARTHQUAKE; ALASKA; JAPAN AB [1] The inverse method provides tsunami forecasts through regression of near-field water-level data against a set of mareograms computed for unit slip of predetermined subfaults. The present paper describes an improvement to this inverse method by resolving the timing of subfault movement in the inversion. This provides additional degrees of freedom in the regression analysis and accounts for rupture propagation and rise time of tsunamigenic earthquakes. The method is implemented for the Peru-Chile subduction zone, in which the seismic source parameters are deduced from previous studies of seismotectonics and historical earthquakes. A hindcast analysis of the 1995 Antofagasta-Chile tsunami demonstrates the capability of the adaptive inverse algorithm in improving the near-field inversion results and consequently the far-field forecast. C1 USA, Corps Engineers, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA. RP Cheung, KF (reprint author), USA, Corps Engineers, Coastal & Hydraul Lab, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. EM cheung@hawaii.edu NR 16 TC 9 Z9 9 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD JUL 7 PY 2007 VL 34 IS 13 AR L13605 DI 10.1029/2007GL030158 PG 6 WC Geosciences, Multidisciplinary SC Geology GA 187WS UT WOS:000247880400004 ER PT J AU Chen, RW Lu, XCM Yao, CP Liao, ZL Jiang, ZG Wei, H Ghanbari, HA Tortella, FC Dave, JR AF Chen, Ren-Wu Lu, X.-C. May Yao, Changping Liao, Zhilin Jiang, Zhi-Gang Wei, Hans Ghanbari, Hossein A. Tortella, Frank C. Dave, Jitendra R. TI PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK SO NEUROSCIENCE LETTERS LA English DT Article DE PAN-811; neuroprotection; glutamate toxicity; c-jun N-terminal kinase; mitogen-activated protein kinase; Bcl-2 ID N-TERMINAL KINASE; BAX TRANSLOCATION; PROTEIN-KINASE; NEURONAL APOPTOSIS; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; DEPENDENT APOPTOSIS; CEREBRAL-ISCHEMIA; SIGNALING PATHWAY; BCL-2 EXPRESSION; CELL-DEATH AB In an earlier study, we demonstrated that PAN-811 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel neuroprotectant, provides protection against glutamate, staurosporine, veratridine, or hypoxia/hypoglycemia toxicities in primary cortical neuronal cultures by upregulating Bcl-2 expression [R.-W. Chen, C. Yao, X.C. Lu, Z.-G. Jiang, R. Whipple, Z. Liao, H.A. Ghanbari, B. Almassian, F.C. Tortella, J.R. Dave. PAN-811 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel neuroprotectant, elicits its function in primary neuronal cultures by upregulating Bcl-2 expression. Neuroscience 135 (2005) 191-201]. Both JNK (c-Jun N-terminal kinase) and p38 MAP (mitogen-activated protein) kinase activation have a direct inhibitory action on Bcl-2 by phosphorylation. In the present study, we continued to explore the mechanism of PAN-811 neurciprotection. Our results indicate that treatment of cultured cortical neurons with glutamate (100 mu M) induces phosphorylation of both JNK and p38 MAPK. Specifically, pretreatment of neurons with 10 mu M PAN-811 (an optimal neuroprotective concentration) for 1 h, 4 h, or 24 h significantly suppresses glutamate-mediated activation of both JNK and p38 MAPK. Furthermore, the p38 MAPK-specific inhibitor SB203580 and the JNK-specific inhibitor SP600125 prevented glutamate-induced neuronal death in these primary cultures. Our results demonstrate that glutamate-induced phosphorylation of JNK and p38 MAPK is suppressed by PAN-811, which might contribute to Bcl-2 upregulation and PAN-811 neuroprotection. (c) 2007 Elsevier Ireland Ltd. All rights reserved. C1 Walter Reed Army Inst Res, Div Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. Panacea Pharmaceut, Gaithersburg, MD 20877 USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jit.dave@na.amedd.army.mil RI Yao, Changping/B-3619-2011 FU NHLBI NIH HHS [9R44HL085043-02] NR 28 TC 16 Z9 19 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD JUL 5 PY 2007 VL 422 IS 1 BP 64 EP 67 DI 10.1016/j.neulet.2007.06.004 PG 4 WC Neurosciences SC Neurosciences & Neurology GA 202BF UT WOS:000248875800013 PM 17600621 ER PT J AU Foreman, JV Everitt, HO Yang, J Liu, J AF Foreman, J. V. Everitt, H. O. Yang, J. Liu, J. TI Influence of temperature and photoexcitation density on the quantum efficiency of defect emission in ZnO powders SO APPLIED PHYSICS LETTERS LA English DT Article ID PHOSPHORS; PHOTOLUMINESCENCE; LUMINESCENCE; MECHANISM AB The effect of laser excitation power density on the efficiency of intrinsic defect emission in ZnO powders was characterized by varying the laser irradiance over three orders of magnitude and monitoring changes in the samples' photoluminescence. The external quantum efficiency of the visible wavelength, broadband defect photoluminescence was found to depend not only on laser irradiance but also on temperature and prior annealing conditions. This material system is potentially useful as an ultraviolet-photoexcited, white light phosphor under low-power excitation (< 0.2 W/cm(2)) at room temperature and below. (c) 2007 American Institute of Physics. C1 Duke Univ, Dept Phys, Durham, NC 27708 USA. Duke Univ, Dept Chem, Durham, NC 27708 USA. USA, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA. RP Everitt, HO (reprint author), Duke Univ, Dept Phys, Durham, NC 27708 USA. EM everitt@phy.duke.edu RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 18 TC 14 Z9 14 U1 0 U2 6 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 2 PY 2007 VL 91 IS 1 AR 011902 DI 10.1063/1.2753540 PG 3 WC Physics, Applied SC Physics GA 187AM UT WOS:000247819700020 ER PT J AU Williams, AJ Wei, HH Dave, JR Tortella, FC AF Williams, Anthony J. Wei, Hans H. Dave, Jitendra R. Tortella, Frank C. TI Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat SO JOURNAL OF NEUROINFLAMMATION LA English DT Article ID INFLAMMATORY GENE-EXPRESSION; FACTOR-KAPPA-B; PROTEASOME INHIBITOR MLN519; FIBRILLARY ACIDIC PROTEIN; MIDDLE CEREBRAL-ARTERY; LEUKOCYTE INFILTRATION; PURINERGIC RECEPTORS; ADHESION MOLECULES; REDUCES INFARCTION; GLIAL-CELLS AB Background: Neuroinflammation following acute brain trauma is considered to play a prominent role in both the pathological and reconstructive response of the brain to injury. Here we characterize and contrast both an acute and delayed phase of inflammation following experimental penetrating ballistic brain injury ( PBBI) in rats out to 7 days post- injury. Methods: Quantitative real time PCR ( QRT- PCR) was used to evaluate changes in inflammatory gene expression from the brain tissue of rats exposed to a unilateral frontal PBBI. Brain histopathology was assessed using hematoxylin and eosin ( H& E), silver staining, and immunoreactivity for astrocytes ( GFAP), microglia ( OX- 18) and the inflammatory proteins IL- 1 beta and ICAM- 1. Results: Time course analysis of gene expression levels using QRT- PCR indicated a peak increase during the acute phase of the injury between 3 - 6 h for the cytokines TNF-alpha (8 - 11 fold), IL- 1 beta (11-13 fold), and IL- 6 ( 40 - 74 fold) as well as the cellular adhesion molecules VCAM ( 2 - 3 fold), ICAM-I ( 7 - 15 fold), and E- selectin ( 11 - 13 fold). Consistent with the upregulation of pro- inflammatory genes, peripheral blood cell infiltration was a prominent post- injury event with peak levels of infiltrating neutrophils ( 24 h) and macrophages ( 72 h) observed throughout the core lesion. In regions of the forebrain immediately surrounding the lesion, strong immunoreactivity for activated astrocytes ( GFAP) was observed as early as 6 h post- injury followed by prominent microglial reactivity ( OX- 18) at 72 h and resolution of both cell types in cortical brain regions by day 7. Delayed thalamic inflammation ( remote from the primary lesion) was also observed as indicated by both microglial and astrocyte reactivity ( 72 h to 7 days) concomitant with the presence of fiber degeneration ( silver staining). Conclusion: In summary, PBBI induces both an acute and delayed neuroinflammatory response occurring in distinct brain regions, which may provide useful diagnostic information for the treatment of this type of brain injury. C1 Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. EM anthony.williams@na.amedd.army.mil; hans.wei@na.amedd.army.mil; dave@na.amedd.army.mil; frank.tortella@na.amedd.army.mil NR 47 TC 59 Z9 64 U1 0 U2 4 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1742-2094 J9 J NEUROINFLAMM JI J. Neuroinflamm. PD JUL 2 PY 2007 VL 4 AR 17 DI 10.1186/1742-2094-4-17 PG 12 WC Immunology; Neurosciences SC Immunology; Neurosciences & Neurology GA 213SE UT WOS:000249686600001 PM 17605820 ER PT J AU Warner, CH Rachal, J Breitbach, J Higgins, M Warner, C Bobo, W AF Warner, Christopher H. Rachal, James Breitbach, Jill Higgins, Michael Warner, Carolynn Bobo, William TI Current perspectives on chief residents in psychiatry SO ACADEMIC PSYCHIATRY LA English DT Article AB Objective: The authors examine qualitative data from outgoing chief residents in psychiatry from the 2004-2005 academic year to 1) determine common characteristics between programs, 2) examine the residents' perspectives on their experiences, and 3) determine their common leadership qualities. Method: The authors sent out self-report surveys via e-mail to 89 outgoing chief residents who attended the APA/Lilly Chief Resident Executive Leadership Program. Results: Fifty-three (60%) chief residents responded. Although most chief residents are senior residents, over 20% are in their third postgraduate year Two-thirds of programs have more than one chief resident each year. Most chief residents believe that their "Participating" leadership style, existing leadership skills, and interpersonal skills contributed to their overall positive experiences. Conclusions: Successfully performing duties as a chief resident entails functioning in a variety of roles and demands attention to leadership qualities of the individual. Developing existing leadership skills, clarifying expectations, and providing mentorship to chief residents will ensure successful transition into practice, and the advancement of the field of psychiatry. C1 Third Infantry Div, Ft Stewart, GA USA. Med Coll Wisconsin, Dept Psychiat & Behav Med, Milwaukee, WI 53226 USA. Ehrling Berquist Air Force Hosp, Dept Psychiat, Offutt AFB, NE USA. Womack army Med Ctr, Dept Psychol, Ft Bragg, NC USA. 436th Med Grp, Dover AFB, DE USA. Winn Army Community Hosp, Ft Stewart, GA USA. Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. RP Warner, CH (reprint author), Winn Army Hosp, Dept Psychiat, 373 Steeple Chase Lane, Richmond Hill, GA 31324 USA. EM christopher.h.wamer@us.army.mil NR 10 TC 5 Z9 5 U1 0 U2 1 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1042-9670 J9 ACAD PSYCHIATR JI Acad. Psych. PD JUL-AUG PY 2007 VL 31 IS 4 BP 270 EP 276 DI 10.1176/appi.ap.31.4.270 PG 7 WC Education & Educational Research; Psychiatry SC Education & Educational Research; Psychiatry GA 190HI UT WOS:000248049500005 PM 17626188 ER PT J AU Ivany, CG Hurt, PH AF Ivany, Christopher G. Hurt, Peyton H. TI Enhancing the effectiveness of the psychiatric chief resident SO ACADEMIC PSYCHIATRY LA English DT Article AB Objective: Despite its importance in psychiatry residency training, there is little written about the role of chief resident. Invoking principles of credibility, continuity, and inclusion, and the establishment of two roles, as legislative and representative leader, this article offers a model for how a residency program can empower its chief resident to act decisively, make meaningful contributions to training, and ultimately enhance his or her effectiveness. Method: The authors review the literature on the psychiatry chief resident and identify ambiguity as a common and powerful impediment to effective leadership. Results: The authors present a model for psychiatry residency programs to enhance chief resident effectiveness based on the three components of credibility, continuity, and inclusion, and elucidate how each improves chief resident leadership. The authors identify two integral leadership roles of the chief resident, those of the legislative and representative leader, and discuss how each empowers the chief resident to act decisively. Conclusions: The authors assert that if psychiatry residency programs elect the chief resident by involving both faculty and residents, grant a year-long term and include him or her in all major decisions that involve the residency, the chief resident is far more likely to make meaningful contributions to the training program. C1 Tripler Army Med Ctr, Dept Child & Adolescent Psychiat, Honolulu, HI 96859 USA. RP Ivany, CG (reprint author), Tripler Army Med Ctr, Dept Child & Adolescent Psychiat, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM christopher.ivany@us.army.mil NR 16 TC 4 Z9 4 U1 0 U2 0 PU AMER PSYCHIATRIC PUBLISHING, INC PI ARLINGTON PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA SN 1042-9670 J9 ACAD PSYCHIATR JI Acad. Psych. PD JUL-AUG PY 2007 VL 31 IS 4 BP 277 EP 280 DI 10.1176/appi.ap.31.4.277 PG 4 WC Education & Educational Research; Psychiatry SC Education & Educational Research; Psychiatry GA 190HI UT WOS:000248049500006 PM 17626189 ER PT J AU Hartzell, JD Weintrob, A AF Hartzell, Joshua D. Weintrob, Amy TI Lipoatrophy: Other treatment options SO AIDS PATIENT CARE AND STDS LA English DT Letter ID HIV-INFECTED PATIENTS; THYMIDINE ANALOG; ABACAVIR; SUBSTITUTION; THERAPY; TRIAL C1 Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Hartzell, JD (reprint author), Walter Reed Army Med Ctr, Dept Med, BLD,Ward 63,6900 Georgia Ave NW, Washington, DC 20307 USA. EM joshua.hartzell@na.amedd.army.mil NR 8 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1087-2914 J9 AIDS PATIENT CARE ST JI Aids Patient Care STDS PD JUL PY 2007 VL 21 IS 7 BP 441 EP 442 DI 10.1089/apc.2006.0186 PG 2 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 197FR UT WOS:000248540500001 PM 17651023 ER PT J AU Scorza, K Williams, A Phillips, JD Shaw, J AF Scorza, Keith Williams, Aaron Phillips, J. Daniel Shaw, Joel TI Evaluation of nausea and vomiting SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID SMALL-BOWEL; INTESTINAL-OBSTRUCTION; CONTROLLED TRIAL; PREGNANCY AB A comprehensive history and physical examination can often reveal the cause of nausea and vomiting, making further evaluation unnecessary. Acute symptoms generally are the result of infectious, inflammatory, or iatrogenic causes. Most infections are self-limiting and require minimal intervention; iatrogenic causes can be resolved by removing the offending agent. Chronic symptoms are usually a pathologic response to any of a variety of conditions. Gastrointestinal etiologies include obstruction, functional disorders, and organic diseases. Central nervous system etiologies are primarily related to conditions that increase intracranial pressure, and typically cause other neurologic signs. Pregnancy is the most common endocrinologic cause of nausea and must be considered in any woman of childbearing age. Numerous metabolic abnormalities and psychiatric diagnoses also may cause nausea and vomiting. Evaluation should first focus on detecting any emergencies or complications that require hospitalization. Attention should then turn to identifying the underlying cause and providing specific therapies. When the cause cannot be determined, empiric therapy with an antiemetic is appropriate. Initial diagnostic testing should generally be limited to basic laboratory tests and plain radiography. Further testing, such as upper endoscopy or computed tomography of the abdomen, should be determined by clinical suspicion based on a complete history and physical examination. C1 USA, Dewitt Community Hosp Family Med Residency, Ft Belvoir, VA USA. RP Scorza, K (reprint author), USA, Dewitt Community Hosp, 9501 Farrel Rd, Ft Belvoir, VA 22060 USA. NR 29 TC 11 Z9 11 U1 0 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL 1 PY 2007 VL 76 IS 1 BP 76 EP 84 PG 9 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 190AS UT WOS:000248030700009 PM 17668843 ER PT J AU Zumbro, DS Jampol, LM Folk, JC Olivier, MMG Anderson-Nelson, S AF Zumbro, David S. Jampol, Lee M. Folk, James C. Olivier, Mildred M. G. Anderson-Nelson, Susan TI Macular schisis and detachment associated with presumed acquired enlarged optic nerve head cups SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID MORNING GLORY SYNDROME; COHERENCE TOMOGRAPHY; PITS; DISC; GLAUCOMA AB PURPOSE: To describe a clinical syndrome of macular schisis and detachment in patients with acquired optic nerve head cupping resulting from glaucoma. DESIGN: Retrospective review of five patients. METHODS: Patients were included if they had optic nerve cupping and macular schisis with or without detachment with no other identifiable cause. The patients had to have no leakage on fluorescein angiography and no vitreous traction on examination or on optic coherence tomography (OCT). These patients were followed up and visual acuity, intraocular pressure, and the findings of serial fundus and OCT examinations were noted. RESULTS: Five patients had schisis with or without detachment of the macula with pronounced optic nerve head cupping. One patient had resolution of the macular fluid after filtering surgery for uncontrolled glaucoma. Two patients underwent a vitrectomy with intraocular gas and had almost total resolution of macular fluid and improved vision. CONCLUSIONS: Macular schisis and detachment can occur in patients with presumed enlarged optic nerve head cups in the absence of obvious congenital anomalies of the disk. The authors believe the cause is leakage of fluid from the vitreous through a tiny hole in the thin tissue of the cup. This is a similar mechanism to that seen in patients with optic pits. A vitrectomy or steps to reduce the intraocular pressure may result in resolution of the fluid and improved vision. C1 Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA. Brooke Army Med Ctr, Ophthalmol Serv, Houston, TX USA. Northwestern Univ, Dept Ophthalmol, Chicago, IL USA. John H Stroger Jr Hosp Cook Cty, Glaucoma Div, Chicago, IL USA. Rosalind Franklin Univ Med & Sci, Chicago, IL USA. Midwestern Univ, St James Osteopath Hosp, Chicago, IL USA. Wheaton Eye Clin, Wheaton, IL USA. RP Zumbro, DS (reprint author), Univ Iowa, Dept Ophthalmol & Visual Sci, 200 Hawkins Dr, Iowa City, IA 52242 USA. EM james-folk@uiowa.edu NR 15 TC 19 Z9 19 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD JUL PY 2007 VL 144 IS 1 BP 70 EP 74 DI 10.1016/j.ajo.2007.03.027 PG 5 WC Ophthalmology SC Ophthalmology GA 187SD UT WOS:000247867800011 PM 17493573 ER PT J AU Rickards, CA Ryan, KL Cooke, WH Lurie, KG Convertino, VA AF Rickards, Caroline A. Ryan, Kathy L. Cooke, William H. Lurie, Keith G. Convertino, Victor A. TI Inspiratory resistance delays the reporting of symptoms with central hypovolemia: association with cerebral blood flow SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY LA English DT Article ID BODY NEGATIVE-PRESSURE; DECOMPRESSION CARDIOPULMONARY-RESUSCITATION; IMPEDANCE THRESHOLD DEVICE; HOSPITAL CARDIAC-ARREST; PORCINE MODEL; ORTHOSTATIC HYPOTENSION; SYMPATHETIC RESPONSES; PERFUSION PRESSURES; HEMORRHAGIC-SHOCK; HUMANS AB We tested the hypothesis that breathing through an inspiratory threshold device (ITD) during progressive central hypovolemia would protect cerebral perfusion and attenuate the reporting of presyncopal symptoms. Eight human subjects were exposed to lower-body negative pressure (LBNP) until the presence of symptoms while breathing through either an active ITD (-7 cmH(2)O impedance) or a sham ITD (0 cmH(2)O). Cerebral blood flow velocity (CBFV) was measured continuously via transcranial Doppler and analyzed in both time and frequency domains. Subjects were asked to report any Subjective presyncopal symptoms (e.g., dizziness, nausea) at the conclusion of each LBNP exposure. Symptoms were coincident with physiological evidence of cardiovascular collapse (e.g., hypotension, bradycardia). Breathing on the active ITD increased LBNP tolerance time (mean +/- SE) from 2,014 +/- 106 s to 2,259 +/- 138 s (P = 0.006). We compared CBFV responses at the time of symptoms during the sham ITD trial with those at the same absolute time during the active ITD trial (when there were no symptoms). While there was no difference in mean CBFV at these time points (sham, 44 +/- 4 cm/s vs. active, 47 +/- 4; P = 0.587), total oscillations (sum of high-and low-frequency spectral power) of CBFV were higher (P = 0.004) with the active ITD (45.6 +/- 10.2 cm/s(2)) than the sham ITD (22.1 +/- 5.4 cm/s(2)). We conclude that greater oscillations around the same absolute level of mean CBFV are induced by inspiratory resistance and may contribute to the delay in symptoms and cardiovascular collapse that accompany progressive central hypovolemia. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Rickards, CA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave Bldg 3611, Ft Sam Houston, TX 78234 USA. EM carolinerickards@hotmail.com NR 41 TC 29 Z9 29 U1 0 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0363-6119 J9 AM J PHYSIOL-REG I JI Am. J. Physiol.-Regul. Integr. Comp. Physiol. PD JUL PY 2007 VL 293 IS 1 BP R243 EP R250 DI 10.1152/ajpregu.00087.2007 PG 8 WC Physiology SC Physiology GA 189DX UT WOS:000247970700030 PM 17507439 ER PT J AU Owens, MAJBD Duffey, ML Bradley, LTC Nelson, J DeBerardino, LTM Taylor, CRDC Mountcastle, SB AF Owens, M. A. J. Brett D. Duffey, Michele L. Bradley, L. T. C. Nelson, J. DeBerardino, L. T. C. Thomas M. Taylor, C. O. L. (Ret) Dean C. Mountcastle, Sally B. TI The incidence and characteristics of shoulder instability at the united states military academy SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article DE shoulder; instability; dislocation; subluxation; epidemiology; incidence; mechanism ID DISLOCATIONS; SUBLUXATION AB Background: The literature provides little information detailing the incidence of traumatic shoulder instability in young, healthy athletes. Hypothesis: Shoulder instability is common in young athletes. Study Design: Descriptive epidemiologic study. Methods: We prospectively captured all traumatic shoulder instability events at the United States Military Academy between September 1, 2004, and May 31, 2005. Throughout this period, all new traumatic shoulder instability events were evaluated with physical examination, plain radiographs, and magnetic resonance imaging. Instability events were classified according to direction, chronicity, and type (subluxation or dislocation). Subject demographics, mechanism of injury, and sport were evaluated. Results: Among 4141 students, 117 experienced new traumatic shoulder instability events during the study period; 11 experienced multiple events. The mean age of these 117 subjects was 20.0 years; 101 students were men (86.3%), and 16 were women (13.7%). The 1-year incidence proportion was 2.8%. The male incidence proportion was 2,9% and the female incidence proportion was 2.5%. Eighteen events were dislocations (15.4%), and 99 were subluxations (84.6%). Of the 99 subluxations, 45 (45.5%) were primary events, while 54 (54.5%) were recurrent. Of the 18 dislocations, 12 (66.7%) were primary events, while 6 (33.3%) were recurrent. The majority of the 117 events were anterior in nature (80.3%), while 12 (10.3%) were posterior, and 11 (9.4%) were multidirectional. Forty-four percent (43.6%) of the instability events experienced were as a result of contact injuries, while 41.0% were a result of noncontact injuries, including 9 subluxations caused by missed punches during boxing; information was unavailable for the remaining 15%. Conclusion: Glenohumeral instability is a common injury in this population, with subluxations comprising 85% of instability events. C1 US Mil Acad, Keller Army Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. Univ Minnesota, Dept Orthopaed Surg, Minneapolis, MN 55455 USA. Duke Univ, Med Ctr, Div Orthopaed Surg, Durham, NC USA. RP Owens, MAJBD (reprint author), US Mil Acad, Keller Army Hosp, Orthopaed Surg Serv, West Point, NY 10996 USA. EM b.owens@us.army.mi1 OI DeBerardino, Thomas/0000-0002-7110-8743 NR 19 TC 23 Z9 24 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD JUL PY 2007 VL 35 IS 7 BP 1168 EP 1173 DI 10.1177/0363546506295179 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 186XZ UT WOS:000247813200017 PM 17581976 ER PT J AU Convertino, VA AF Convertino, Victor A. TI Blood volume response to physical activity and inactivity SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article; Proceedings Paper CT Annual Meeting of the Southern-Society-for-Clinical-Investigation CY MAR 03-05, 2006 CL Atlanta, GA DE physical fitness; cardiovascular; thermoregulation; exercise; bed rest ID TRAINING-INDUCED HYPERVOLEMIA; PLASMA-VOLUME; BED REST; VASCULAR-RESISTANCE; PROLONGED EXERCISE; DISTANCE RUNNERS; MIDDLE-DISTANCE; STROKE VOLUME; HEART-RATE; HUMANS AB Data from both cross-sectional and longitudinal studies provide compelling evidence that circulating blood volume can be influenced by regular physical activity or inactivity. Expansion or contraction of plasma volume can account for most of the alteration in circulating blood volume during the initial I to 2 weeks of changing physical activity patterns; after this time, altered blood volume may be distributed equally between plasma and red cell volumes. Alterations in circulating blood volume that accompany changes in physical activity represent a net change in total body water and solutes that are associated with increased or decreased water intake and urine volume and solute output. The mechanism of altered urine output appears to be a modified renal tubular reabsorption of sodium. The expansion of blood volume that accompanies physical activity provides advantages of greater body fluid for heat dissipation (sweating) and thermoregulatory stability as well as larger vascular volume for greater cardiac filling and stroke volume and cardiovascular stability during exercise and orthostatic challenges. The opposite is true when blood volume is reduced during periods of relative physical inactivity. The observation that underlying mechanisms for alteration in blood volume with physical activity and inactivity are similar but respond directly opposite suggests that they are intricately related. These relations have implications as to a mechanism by which physical activity and fitness may be protective against reduced blood volume and subsequent development of cardiovascular disease associated with aging. C1 USA, Inst Surg Res, Remote Tirage Res Lab, Ft Sam Houston, TX USA. RP Convertino, VA (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA. EM victor.convertino@amedd.army.mil NR 49 TC 40 Z9 40 U1 2 U2 19 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD JUL PY 2007 VL 334 IS 1 BP 72 EP 79 DI 10.1097/MAJ.0b013e318063c6e4 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA 191VJ UT WOS:000248159800014 PM 17630597 ER PT J AU Shanks, GD Magill, AJ Freedman, DO Keystone, JS Bradley, DJ Steffen, R AF Shanks, G. Dennis Magill, Alan J. Freedman, David O. Keystone, Jay S. Bradley, David J. Steffen, Robert TI Drug-free holidays: Pre-travel versus during travel malaria chemoprophylaxis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Editorial Material ID TAFENOQUINE; PROPHYLAXIS; ATOVAQUONE AB Although efficacious forms of malaria chemoprophylaxis currently exist, many travelers to malaria-endemic areas fail to use them effectively. We suggest that taking anti-malarial medications prior to travel may prevent more malaria by improving compliance. Treatment regimens of antimalarial drugs taken prior to travel could protect persons for up to one month of exposure. We urge additional testing of pre-travel malaria chemoprophylaxis regimens. C1 Army Malaria Inst, Brisbane, Qld 4051, Australia. Walter Reed Army Inst Res, Silver Spring, MD USA. Univ Alabama, Birmingham, AL USA. Toronto Hosp, Toronto, ON M5T 2S8, Canada. London Sch Hyg & Trop Med, London WC1, England. Univ Zurich, WHO, Collaborating Ctr Travelers Hlth, Zurich, Switzerland. RP Shanks, GD (reprint author), Army Malaria Inst, Brisbane, Qld 4051, Australia. EM dennis.shanks@defence.gov.au RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 10 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2007 VL 77 IS 1 BP 1 EP 2 PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 189HK UT WOS:000247979800001 PM 17620622 ER PT J AU Jacobson, JA Hills, SL Winkler, JL Mammen, M Thaisomboonsuk, B Marfin, AA Gibbons, RV AF Jacobson, Julie A. Hills, Susan L. Winkler, Jennifer L. Mammen, Mammen Thaisomboonsuk, Butsaya Marfin, Anthony A. Gibbons, Robert V. TI Evaluation of three immunoglobulin M antibody capture enzyme-linked immunosorbent assays for diagnosis of Japanese encephalitis SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CEREBROSPINAL-FLUID; VIRUS; SERUM; IGM AB Japanese encephalitis (JE) virus is a major cause of neurologic infection in Asia, but surveillance has been limited. Three JE immunoglobulin M (IgM) antibody capture enzyme-linked immunosorbent assay kits have recently been developed. The aim of this study was to evaluate their sensitivity, specificity, and usability using 360 acute-phase serum samples containing JE, dengue, or neither IgM antibody. The kits, manufactured by Panbio Limited, Inbios International, Inc., and XCyton Diagnostics Ltd, had high sensitivities of 89.3%, 99.2%, and 96.7%, respectively. The specificities were 99.2%, 56.1%, and 65.3%, respectively. When dengue IgM-positive samples were excluded, the kits had specificities of 98.4%, 96.1%, and 96.1%, respectively. The Panbio kit includes both JE and dengue antigens and appears to have an advantage in settings where dengue virus co-circulates, although further assessments in clinical settings are needed. This information is helpful in considering options for strengthening the laboratory component of JE surveillance. C1 PATH, Japanese Encephalitis Project, Seattle, WA 98107 USA. Armed Forces Res Inst Med Sci, USA Med Component, Dept Virol, Bangkok 10400, Thailand. Ctr Dis Control & Prevent, Div Global Migrat & Quarantine, Seattle, WA 98121 USA. RP Jacobson, JA (reprint author), PATH, Japanese Encephalitis Project, 1455 NW LEary Way, Seattle, WA 98107 USA. EM jjacobs@path.org; shills@path.org; jwinkler@path.org; mammen.mammen@us.army.mil; ButsayaT@afrims.org; aam0@cdc.gov; Robert.Gibbons@afrims.org NR 16 TC 20 Z9 23 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 2007 VL 77 IS 1 BP 164 EP 168 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 189HK UT WOS:000247979800028 PM 17620649 ER PT J AU Cohen, SP Wenzell, D Hurley, RW Kurihara, C Buckenmaier, CC Griffith, S Larkin, TM Dahl, E Morlando, BJ AF Cohen, Steven P. Wenzell, Daniel Hurley, Robert W. Kurihara, Connie Buckenmaier, Chester C., III Griffith, Scott Larkin, Thomas M. Dahl, Erik Morlando, Bennie J. TI A double-blind, placebo-controlled, dose-response pilot study evaluating intradiscal etanercept in patients with chronic discogenic low back pain or lumbosacral radiculopathy SO ANESTHESIOLOGY LA English DT Article ID TUMOR-NECROSIS-FACTOR; HERNIATION-INDUCED SCIATICA; TNF-ALPHA INHIBITION; NUCLEUS-PULPOSUS; DISC HERNIATION; ELECTROTHERMAL THERAPY; LUMBAR DISCOGRAPHY; RISK-FACTORS; FOLLOW-UP; EFFICACY AB Background: in recent years, convincing evidence has emerged implicating tumor necrosis factor a as a causative factor in radiculopathy and discogenic back pain. But although preliminary open-label studies demonstrated promising results for the treatment of low back pain with tumor necrosis factor-a inhibitors. early optimism has been tainted by a controlled study showing no significant benefit in sciatica. To determine whether outcomes might be improved by a more direct route of administration, the authors evaluated escalating doses of intradiscal etanercept it, 36 patients with chronic lumbosacral radiculopathy or discogenic low back pain. Methods: A double-blind, placebo-controlled pilot study was conducted whereby six patients received 0.1, 0.25, 0.5, 0.75, 1.0, or 1.5 mg etanercept intradiscally in each pain-generating disc. in each escalating dose group of six patients, one received placebo. A neurologic examination and postprocedure leukocyte counts were performed in all patients at 1-month follow-up visits. In patients who experienced significant improvement in pain scores and function, follow-up visits were conducted 3 and 6 months after the procedure. Results: At 1-month follow-up, no differences were found for pain scores or disability scores between or within groups for any dose range or subgroup of patients. Only eight patients remained in the study after I month and elected to forego further treatment. No complications were reported, and no differences were noted between preprocedure and postprocedure leukocyte counts. Conclusions: Although no serious side effects were observed in this small study, a single low dose of intradiscal etanercept does not seem to be an effective treatment for chronic radicular or discogenic low back pain. C1 Johns Hopkins Univ, Sch Med, Pain Management Div, Dept Anesthesia & Crit Care Med, Baltimore, MD 21205 USA. Walter Reed Army Med Ctr, Anesthesia Serv, Dept Surg, Tacoma, WA USA. Madigan Army Med Ctr, Dept Surg, MAJ D Wenzell, Tacoma, WA USA. RP Cohen, SP (reprint author), Johns Hopkins Univ, Sch Med, Pain Management Div, Dept Anesthesia & Crit Care Med, 550 N Broadway,Suite 301, Baltimore, MD 21205 USA. EM scohen40@jhmi.edu NR 36 TC 39 Z9 40 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD JUL PY 2007 VL 107 IS 1 BP 99 EP 105 DI 10.1097/01.anes.0000267518.20363.0d PG 7 WC Anesthesiology SC Anesthesiology GA 184AK UT WOS:000247613300017 PM 17585221 ER PT J AU Williams, JB Orr, SC AF Williams, Justin B. Orr, Scott C. TI Acute submandibular sialadenitis with infected sialocele SO ANNALS OF EMERGENCY MEDICINE LA English DT Editorial Material ID SALIVARY-GLANDS C1 Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium E, Ft Sam Houston, TX 78234 USA. RP Williams, JB (reprint author), Brooke Army Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium E, Ft Sam Houston, TX 78234 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUL PY 2007 VL 50 IS 1 BP 13 EP + DI 10.1016/j.annemergmed.2006.11.017 PG 2 WC Emergency Medicine SC Emergency Medicine GA 186IX UT WOS:000247773500003 PM 17572288 ER PT J AU Griffith, ME Moon, JE Johnson, EN Clark, KP Hawley, JS Hospenthal, DR Murray, CK AF Griffith, Matthew E. Moon, James E. Johnson, Erica N. Clark, Kyra P. Hawley, Joshua S. Hospenthal, Duane R. Murray, Clinton K. TI Efficacy of fluoroquinolones against Leptospira interrogans in a hamster model SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID MYCOPLASMA-PNEUMONIAE; CIPROFLOXACIN; PHARMACODYNAMICS; DRUG AB Ciprofloxacin, gatifloxacin, and levofloxacin were evaluated for their abilities to prevent mortality in hamsters infected with a lethal inoculum of Leptospira interrogans serovar Portlandvere. Each agent produced a statistically significant survival advantage compared to no treatment and demonstrated survival similar to that seen with doxycycline therapy. C1 Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, Houston, TX 78234 USA. RP Griffith, ME (reprint author), Brooke Army Med Ctr, Infect Dis Serv, MCHE MDI, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM matthew.griffith@amedd.army.mil RI Valle, Ruben/A-7512-2013; Moon, James/B-6810-2011 OI Moon, James/0000-0002-9274-4554 NR 14 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 2007 VL 51 IS 7 BP 2615 EP 2617 DI 10.1128/AAC.00240-07 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 184TS UT WOS:000247665800047 PM 17470646 ER PT J AU Jaeger, SR Cardello, AV AF Jaeger, Sara R. Cardello, Armand V. TI A construct analysis of meal convenience applied to military foods SO APPETITE LA English DT Article DE meals; military feeding; time; effort; food provisioning process; type of convenience; timing of convenience; discrete choice experimentation ID CONSUMER-BEHAVIOR; DECISION-MAKING; DURATION MATTER; WORKING WIVES; TIME; CONSUMPTION; PATTERNS; PERCEPTION; JUDGMENT; EPISODES AB The present research investigates the concept of food convenience within the institutional framework of military feeding. The approach views food-related convenience in terms of two broad dimensions: "type of convenience" and "timing of convenience." A discrete choice experiment was conducted with US military personnel (n = 179) regarding their perceptions of the (in)convenience associated with the use and consumption of low-preparation, all-in-one, military meals (MREs-meals, ready-to-eat). The obtained data strongly suggest that perceived (in)convenience, time and effort are separate constructs. A food provisioning process perspective was captured in the "timing of convenience" dimension, and the contribution of different stages in the consumption process to the perceived convenience of the meal situation was empirically demonstrated. The latter result has important implications for the study of food convenience outside this specific population and context. As opposed to the product perspective that is currently predominant in the literature, it demonstrates the necessity of adopting a meal perspective in analysing food-related convenience. (c) 2007 Elsevier Ltd. All rights reserved. C1 USA, Natl Soldier Ctr, Natick, MA 01760 USA. RP Jaeger, SR (reprint author), Univ Auckland, Sch Business, Private Bag, Auckland 92019, New Zealand. EM s.jaeger@auckland.ac.nz RI Jaeger, Sara/R-2648-2016 NR 55 TC 5 Z9 5 U1 3 U2 9 PU ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0195-6663 J9 APPETITE JI Appetite PD JUL PY 2007 VL 49 IS 1 BP 231 EP 239 DI 10.1016/j.appet.2007.02.001 PG 9 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA 184EK UT WOS:000247623700026 PM 17399852 ER PT J AU Voshchinnikov, NV Videen, G Henning, T AF Voshchinnikov, Nikolai V. Videen, Gorden Henning, Thomas TI Effective medium theories for irregular fluffy structures: aggregation of small particles SO APPLIED OPTICS LA English DT Article; Proceedings Paper CT Topical Meeting of the Optical-Society-of America on Computational Sensing and Imaging CY JUN, 2007 CL Vancouver, CANADA SP Opt Soc Amer ID OPTICAL-PROPERTIES; GRAINS; COMPOSITE; SCATTERING; CONSTANTS; DATABASE; LIGHT AB The extinction efficiencies as well as the scattering properties of particles of different porosity are studied. Calculations are performed for porous pseudospheres with small size (Rayleigh) inclusions using the discrete dipole approximation. Five refractive indices of materials covering the range from 1.20 + 0.00i to 1.75 + 0.58i were selected. They correspond to biological particles, dirty ice, silicate, and amorphous carbon and soot in the visual part of the spectrum. We attempt to describe the optical properties of such particles using Lorenz-Mie theory and a refractive index found from some effective medium theory (EMT) assuming the particle is homogeneous. We refer to this as the effective model. It is found that the deviations are minimal when utilizing the EMT based on the Bruggeman mixing rule. usually the deviations in the extinction factor do not exceed similar to 5% for particle porosity P = 0 - 0.9 and size parameters x(porous) = 2 pi r(s,porous)/lambda less than or similar to 25. The deviations are larger for scattering and absorption efficiencies and smaller for particle albedo and the asymmetry parameter. Our calculations made for spheroids confirm these conclusions. Preliminary consideration shows that the effective model represents the intensity and polarization of radiation scattered by fluffy aggregates quite well. Thus the effective models of spherical and nonspherical particles can be used to significantly simplify the computations of the optical properties of aggregates containing only Rayleigh inclusions. (C) 2007 Optical Society of America. C1 St Petersburg State Univ, Sobolev Astron Inst, St Petersburg 198504, Russia. USA, Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA. Max Planck Inst Astron, D-69117 Heidelberg, Germany. RP Voshchinnikov, NV (reprint author), St Petersburg State Univ, Sobolev Astron Inst, St Petersburg 198504, Russia. EM nvv@astro.spbu.ru RI Voshchinnikov, Nikolai/J-3995-2013; Voshchinnikov, Nikolai/N-4665-2015 OI Voshchinnikov, Nikolai/0000-0001-8327-6894; Voshchinnikov, Nikolai/0000-0001-8327-6894 NR 22 TC 37 Z9 39 U1 1 U2 11 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 2007 VL 46 IS 19 BP 4065 EP 4072 DI 10.1364/AO.46.004065 PG 8 WC Optics SC Optics GA 182OA UT WOS:000247512700023 PM 17571148 ER PT J AU Murray, CK Hoffmaster, RM Schmit, DR Hospenthal, DR Ward, JA Cancio, LC Wolf, SE AF Murray, Clinton K. Hoffmaster, Roselle M. Schmit, David R. Hospenthal, Duane R. Ward, John A. Cancio, Leopoldo C. Wolf, Steven E. TI Evaluation of white blood cell count, neutrophil percentage, and elevated temperature as predictors of bloodstream infection in burn patients SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 43rd Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 06-09, 2005 CL San Francisco, CA SP Infect Dis Soc Amer ID INADEQUATE ANTIMICROBIAL TREATMENT; MEDICAL PATIENTS; SEPTIC SHOCK; FEVER; BACTEREMIA; GUIDELINES; FUNGEMIA; OUTCOMES; SEPSIS; HOST AB Objective: To investigate whether specific values of or changes in temperature, white blood cell count, or neutrophil percentage were predictive of bloodstream infection in burn patients. Design: Retrospective review of electronic records. Setting: Intensive care center at the US Army Institute of Surgical Research Burn Center. Patients: Burn patients with blood cultures obtained from 2001 to 2004. Main Outcome Measures: Temperature recorded at the time blood cultures were obtained; highest temperature in each 6-hour interval during the 24 hours prior to this; white blood cell count and neutrophil percentage at the time of obtaining the blood culture and during the 24 hours preceding the blood culture; demographic data; and total body surface area burned. Results: A total of 1063 blood cultures were obtained from 223 patients. Seventy-three people had 140 blood cultures from which microorganisms were recovered. Organisms that were recovered from blood cultures included 80 that were gram negative, 54 that were gram positive, 3 that were mixed gram positive/gram negative, and 3 yeasts. Although white blood cell count and neutrophil percentage at the time of the culture were statistically different between patients with and patients without bloodstream infection, receiver operating characteristic curve analysis revealed these values to be poor discriminators ( receiver operating characteristic curve area = 0.624). Temperature or alterations in temperature in the preceding 24-hour period did not predict presence, absence, or type of bloodstream infection. Conclusions: Temperature, white blood cell count, neutrophil percentage, or changes in these values were not clinically reliable in predicting bloodstream infection. Further work is needed to identify alternative clinical parameters, which should prompt blood culture evaluations in this population. C1 Brooke Army Med Ctr, Ctr Infect Dis, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Ctr Infect Dis, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 24 TC 22 Z9 25 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JUL PY 2007 VL 142 IS 7 BP 639 EP 642 DI 10.1001/archsurg.142.7.639 PG 4 WC Surgery SC Surgery GA 188IN UT WOS:000247913700014 PM 17638801 ER PT J AU Heinlen, LD McClain, MT Merrill, J Akbarali, YW Edgerton, CC Harley, JB James, JA AF Heinlen, Latisha D. McClain, Micah T. Merrill, Joan Akbarali, Yasmin W. Edgerton, Colin C. Harley, John B. James, Judith A. TI Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms SO ARTHRITIS AND RHEUMATISM LA English DT Article ID CONNECTIVE-TISSUE DISEASE; REVISED CRITERIA; NATURAL-HISTORY; ANTI-DSDNA; FOLLOW-UP; CLASSIFICATION; UCTD; ANTIBODIES; EVOLUTION; RO AB Objective. Specific events that occur during the development of systemic lupus erythematosus (SLE) can be quite variable among individual patients. The aim of this study was to identify patterns that distinguish early clinical events in SLE and to assess whether the presence of associated autoantibodies precedes the fulfillment of clinical criteria. Methods. Through a retrospective chart review of military medical records, 130 patients who met the American College of Rheumatology (ACR) criteria for the classification of SLE were identified. The initial time at which each criterion was fulfilled was recorded. Autoantibody analysis was performed on serum samples, using enzyme-linked immunosorbent assays or immunofluorescence. Results. The clinical features that were observed earliest were discoid rash and seizures, which developed a mean 1.74 and 1.70 years, respectively, before the diagnosis of SLE; however, arthritis was the criterion that was most commonly observed before diagnosis. The presence of IgG rheumatoid factor (IgG-RF) preceded the development of arthritis in 15 (94%) of the 16 patients who were positive for IgG-RF and in whom arthritis developed (Z = 10.2, P < 0.0001). Analogously, IgM-RF appeared before the development of arthritis in 13 (76%) of 17 patients. Anti-double-stranded DNA antibodies were associated with renal disease and appeared before evidence of nephritis in most patients (92%) (Z = 13.3, P < 0.0001). An analysis of the appearance of autoantibodies compared with the appearance of clinical criteria not associated with them revealed no significant temporal relationship. Conclusion. Symptoms associated with the ACR criteria for classification of SLE are commonly present before the diagnosis of SLE, and development of organ-associated autoantibodies generally precedes the appearance of their associated clinical features. C1 Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA. Univ Oklahoma, Hlth Sci Ctr, Norman, OK 73019 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Vet Affairs Med Ctr, Oklahoma City, OK USA. RP James, JA (reprint author), Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA. EM jamesj@omrf.ouhsc.edu FU NCRR NIH HHS [RR-15577, RR-20143]; NIAID NIH HHS [AI-62629, AI-31584, AI-50350]; NIAMS NIH HHS [AR-45084, AR-48940, AR-49084, AR-48045, AR-45451, P30 AR053483] NR 22 TC 81 Z9 89 U1 0 U2 2 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD JUL PY 2007 VL 56 IS 7 BP 2344 EP 2351 DI 10.1002/art.22665 PG 8 WC Rheumatology SC Rheumatology GA 190PP UT WOS:000248071600027 PM 17599763 ER PT J AU Rickards, CA Cohen, KD Bergeron, LL Burton, L Khatri, PJ Lee, CT Ryan, KL Cooke, WH Doerr, DF Convertino, VA AF Rickards, Caroline A. Cohen, Kenneth D. Bergeron, Lindsey L. Burton, Lubrina Khatri, Prateek J. Lee, Christopher T. Ryan, Kathy L. Cooke, William H. Doerr, Donald F. Convertino, Victor A. TI Cerebral blood flow response and its association with symptoms during orthostatic hypotension SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE cerebral autoregulation; squat-stand test; orthostatic symptoms ID HEAD-UP TILT; TRANSCRANIAL DOPPLER; AUTONOMIC FAILURE; HEALTHY-SUBJECTS; FINGER ARTERIAL; CARDIAC-OUTPUT; AUTOREGULATION; HUMANS; PRESSURE; VELOCITY AB Introduction: The preservation of cerebral blood flow with orthostatic hypotension (e.g., following prolonged bed rest or microgravity exposure) is vital for the attenuation of symptoms and the maintenance of consciousness. We tested the hypothesis that decreasing mean arterial pressure (MAP) by > 30% is associated with compromised cerebral autoregulation and orthostatic symptoms during a squat-stand test (SST). Methods: There were 19 subjects who performed an SST. MAP and middle cerebral artery blood flow velocity (CBFV) were recorded continuously. Subjects were divided retrospectively into those who reported: 1) at least one orthostatic symptom (Sx; n = 9); or 2) no orthostatic symptoms (NSx; n = 10). Cerebral autoregulation was assessed via the calculation of time to nadir and time to recovery for MAP and CBFV and linear regression analysis of the dynamic changes in MAP and CBFV (within 10 s of standing). Results: On standing, MAP decreased by 37 +/- 2% (NSx) and 42 +/- 4% (Sx) (p = 0.100). CBFV fell by 6% more in the Sx group than in the NSx group(NSx, -33 +/- 1% vs. Sx, -39 +/- 3%, p = 0.032). Cerebral autoregulation remained intact in both groups as indicated by: 1) a faster time to nadir for CBFV compared with MAP; 2) a faster time to recovery for CBFV compared with MAP; and 3) a poor correlation between CBFV and MAP responses on standing (NSx R-2 = 0.43; Sx R-2 = 0.60). Conclusion: Lower cerebral blood flow during severe hypotension may account for the reporting of orthostatic symptoms, despite the maintenance of cerebral autoregulation. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Bionet Corp, NASA, Kennedy Space Ctr, FL USA. NASA, Spaceflight & Life Sci Training Program, Kennedy Space Ctr, FL USA. NASA, Technol Implementat Branch, Kennedy Space Ctr, FL USA. Univ Texas, Dept Hlth & Kinesiol, San Antonio, TX 78285 USA. RP Rickards, CA (reprint author), USA, Inst Surg Res, 3400 Rawley e Chambers Ave Bldg 3611, Ft Sam Houston, TX 78234 USA. NR 37 TC 10 Z9 10 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 2007 VL 78 IS 7 BP 653 EP 658 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 186KA UT WOS:000247776400002 PM 17679561 ER PT J AU Foley, DH Bryan, JH Wilkerson, RC AF Foley, Desmond H. Bryan, Joan H. Wilkerson, Richard C. TI Species-richness of the Anopheles annulipes complex (Diptera : Culicidae) revealed by tree and model-based allozyme clustering analyses SO BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY LA English DT Article DE Australia; Bayesian; cline; ecological niche modelling; mosquito; myxomatosis; sibling species; species radiation ID NEW-SOUTH-WALES; PAPUA-NEW-GUINEA; WALKER DIPTERA; POPULATION-STRUCTURE; PUNCTULATUS COMPLEX; GRIFFITH; MOSQUITOS; ELECTROPHORESIS; INDIVIDUALS; DISPERSAL AB The Australasian Anopheles annulipes complex contains at least ten sibling species, some of which are important vectors of myxomatosis in rabbits. We aimed to establish how many species occurred among specimens from 61 sites throughout Australia, scored for 32 putative allozyme loci. We compared the number of species predicted from tree-based clustering of operational taxonomic units (OTUs) with that from a novel model-based Bayesian clustering approach for individual genotypes. We rejected the hypothesis of conspecificity of OTUs if they differed by at least 20% fixed differences and 0.300 Nei's standard genetic distance D. According to these criteria, 18-25 species occur, making this the most species-rich anopheline complex known to date. A conservative estimate from the Bayesian analysis was 15-20 species. There was large overlap in the assignment of individuals to clusters inferred from the Bayesian and tree-based analyses. The genetic clustering of northern and southern distributed species and an apparent cline in alleles of the enzyme glucose phosphate isomerase suggest that a latitude-dependent factor, such as temperature, may have played a role in speciation and the subsequent distribution of species. Ecological niche modelling of clusters predicted that none occur in New Guinea, emphasizing that additional, as yet unsampled, species may occur. (c) 2007 The Linnean Society of London, Biological Journal of the Linnean Society, 2007, 91, 523-539. C1 Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. Univ Queensland, Trop Hlth Program, Australian Ctr Int & Trop Hlth & Nutr, Brisbane, Qld 4072, Australia. RP Foley, DH (reprint author), Walter Reed Army Inst Res, Dept Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM foleydes@si.edu OI Foley, Desmond/0000-0001-7525-4601 NR 35 TC 1 Z9 2 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0024-4066 J9 BIOL J LINN SOC JI Biol. J. Linnean Soc. PD JUL PY 2007 VL 91 IS 3 BP 523 EP 539 DI 10.1111/j.1095-8312.2007.00818.x PG 17 WC Evolutionary Biology SC Evolutionary Biology GA 186ZM UT WOS:000247817100018 ER PT J AU McClung, JP Tarr, TN Barnes, BR Scrimgeour, AG Young, AJ AF McClung, James P. Tarr, Tyson N. Barnes, Brian R. Scrimgeour, Angus G. Young, Andrew J. TI Effect of supplemental dietary zinc on the mammalian target of rapamycin (mTOR) signaling pathway in skeletal muscle and liver from post-absorptive mice SO BIOLOGICAL TRACE ELEMENT RESEARCH LA English DT Article DE zinc; mTOR; translation initiation; multiplex analysis; mice ID STIMULATES PROTEIN-SYNTHESIS; TRANSLATION INITIATION; TYROSINE PHOSPHATASES; GENE-EXPRESSION; RAT ADIPOCYTES; INSULIN; PHOSPHORYLATION; S6; FIBROBLASTS; KINASE AB Zinc (Zn) is an essential trace element that functions in cellular signaling. The mammalian target of rapamycin (mTOR) regulates the initiation of protein synthesis. The objective of this study was to determine whether Zn could stimulate protein phosphorylation in the mTOR pathway in vivo. Mice (C57BL/6J, n=30) were fed Zn marginal diets (ZM, 5 mg/kg) for 4 weeks, followed by fasting (F) and/or refeeding with ZM or Zn supplemental (300 mg/kg, ZS) diets for 3 or 6 h. Plasma insulin was greater (P < 0.05) in refed animals as compared to F animals. Protein phosphorylation was detected using multiplex analysis and Western blotting. Multiplex analysis indicated greater (P < 0.05) p70 S6 kinase (p70(S6K)) and glycogen synthase kinase 3 (GSK-3 alpha/beta) phosphorylation in livers from 6-h refed ZS animals as compared to F animals. Western blots indicated increased (P < 0.05) Akt (Ser 473) phosphorylation in skeletal muscle from animals refed ZS diets for 3 and 6 h as compared to F animals. The ZS diet affected phosphorylation of GSK-3 (alpha/beta) in liver, as 3-h ZS refed animals had greater (P < 0.01) phosphorylation than F animals. These findings indicate that Zn may contribute to the initiation of protein synthesis as a signaling molecule in vivo. C1 USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA. RP McClung, JP (reprint author), USA, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM James.McClung@na.amedd.army.mil RI Scrimgeour, Angus/D-6794-2013; McClung, James/A-1989-2009 NR 31 TC 15 Z9 16 U1 1 U2 1 PU HUMANA PRESS INC PI TOTOWA PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA SN 0163-4984 J9 BIOL TRACE ELEM RES JI Biol. Trace Elem. Res. PD JUL PY 2007 VL 118 IS 1 BP 65 EP 76 DI 10.1007/s12011-007-0018-8 PG 12 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA 202NY UT WOS:000248911500009 PM 17848732 ER PT J AU Luo, DW Pullela, SR Marquez, M Cheng, ZD AF Luo, Dawei Pullela, Srinivasa Rao Marquez, Manuel Cheng, Zhengdong TI Cell encapsules with tunable transport and mechanical properties SO BIOMICROFLUIDICS LA English DT Article ID LESS-THAN-100 MU-M; MICROENCAPSULATED ISLETS; AGAROSE-GEL; SIZE; MICE; MICROSPHERES; PANCREAS; CHITOSAN; THERAPY AB We utilized a microfluidic device with hydrodynamic flow focusing geometry to produce uniform agarose droplets in the range of 50 to 110 mu m. The transport property of the thermally gelled particles was tailored by layer-by-layer (LBL) polyelectrolytes coating on the surface and was measured via the release rates of Rhodamine B. The mechanical strength of the capsules was further enhanced by a coating of silica nano-particles in addition to polyelectrolyte coatings. We demonstrated that yeast cells can be successfully encapsulated into agarose capsules. (c) 2007 American Institute of Physics. C1 [Luo, Dawei; Pullela, Srinivasa Rao; Cheng, Zhengdong] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA. [Luo, Dawei] Philip Morris Inc, Grp Postgrad Program, INEST, Richmond, VA 23234 USA. [Marquez, Manuel] NIST, Ctr Theoret & Computat Nanosci, Gaithersburg, MD 20899 USA. [Marquez, Manuel] USA, Richmond, VA 23234 USA. [Marquez, Manuel] Philip Morris Inc, Res Ctr, Richmond, VA 23234 USA. [Marquez, Manuel] Arizona State Univ, Harrington Dept Bioengn, Tempe, AZ 85287 USA. RP Luo, DW (reprint author), Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA. NR 24 TC 17 Z9 17 U1 3 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1932-1058 J9 BIOMICROFLUIDICS JI Biomicrofluidics PD JUL-SEP PY 2007 VL 1 IS 3 AR 034102 DI 10.1063/1.2757156 PG 6 WC Biochemical Research Methods; Biophysics; Nanoscience & Nanotechnology; Physics, Fluids & Plasmas SC Biochemistry & Molecular Biology; Biophysics; Science & Technology - Other Topics; Physics GA 287FD UT WOS:000254901400002 PM 19693358 ER PT J AU Shaheduzzaman, S Vishwanath, A Furusato, B Cullen, J Chen, YM Banez, L Nau, M Ravindranath, L Kim, KH Mohammed, A Chen, YD Ehrich, M Srikantan, V Sesterhenn, IA McLeod, DG Vahey, M Petrovics, Y Dobi, A Srivastava, S AF Shaheduzzaman, Syed Vishwanath, Anu Furusato, Bungo Cullen, Jennifer Chen, Yongmei Banez, Lionel Nau, Martin Ravindranath, Lakshmi Kim, Kee-Hong Mohammed, Ahmed Chen, Yidong Ehrich, Mathias Srikantan, Vasantha Sesterhenn, Isabell A. McLeod, David G. Vahey, Maryanne Petrovics, Yorgy Dobi, Albert Srivastava, Shiv TI Silencing of Lactotransferrin expression by methylation in prostate cancer progression SO CANCER BIOLOGY & THERAPY LA English DT Article DE LTF; downregulation; methylation; PSA doubling time; chemoprevention ID CYCLIN-DEPENDENT KINASES; BOVINE LACTOFERRIN; RADICAL PROSTATECTOMY; COLON CARCINOGENESIS; GROWTH ARREST; CELLS; RECURRENCE; PREVENTION; APOPTOSIS; GENE AB Background: Cancer cells gain selection advantages by the coordinated silencing of protective and by the activation of cell proliferation/cell survival genes. Evaluations of epithelial cell transcriptome of benign and malignant prostate glands by laser capture microdissection (LCM) identified Lactotransferrin (LTF) as the most significantly downregulated gene in prostate cancer (CaP) cells (p < 10(-6)). Frequent downregulation, significant association of LTF with PSA recurrence-free survival in CaP patients and the established anti-tumorigenic effects of LTF in experimental cancer models have provided impetus to evaluate LTF expression features and mechanisms in CaP specimens. Methods: LTF mRNA expression analysis was performed in LCM derived benign and malignant prostate epithelial cells by using Affymetrix GeneChip and QRT-PCR. LTF protein expression was assessed in tissue specimens by immunohistochemistry and in serum samples from CaP patients compared to healthy male control by using ELISA. Mechanism of LTF downregulation was analyzed in 5-azadeoxycytidine treated LNCaP and LAPC4 cells using MALDI-TOF MS. Proliferation and cell cycle analysis of CaP cells by FACS flow cytrometry was assessed in LNCaP cell cultures. Results: Quantitative analysis of LTF mRNA expression in tumor cells revealed marked downregulation of LTF with significant associations to decreased PSA recurrence-free survival of CaP patients (n = 100, p <= 0.0322). Moreover, low levels of LTF protein expression was observed in tumor tissues as well as in sera from CaP patients (p <= 0.0001). LTF promoter downstream CpG island methylation was found in LNCaP and LAPCA cells. Furthermore, replenishing of LTF by supplementing growth media with LTF protein resulted in reduced cell growth. Cell cycle analysis revealed robust increases in apoptosis in response to LTF treatment. Conclusion: This study highlights the potential for LTF in chemoprevention and to become a biologically relevant prognostic marker of CaP, suggesting that silencing of the LTF gene may be causally linked to CaP progression. C1 Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Dept Surg, Ctr Prostate Dis Res, Rockville, MD 20852 USA. Armed Forces Inst Pathol, Dept Genitourinary Pathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Urol Serv, Washington, DC 20307 USA. NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA. WRAIR, Div Retrovirol, Rockville, MD USA. SEQUENOM Inc, San Diego, CA USA. RP Dobi, A (reprint author), Uniformed Serv Univ Hlth Sci, US Mil Canc Inst, Dept Surg, Ctr Prostate Dis Res, 1530 E Jefferson St, Rockville, MD 20852 USA. EM ADobi@cpdr.org; SSrivastava@cpdr.org OI Furusato, Bungo/0000-0003-4614-9882 FU NIDDK NIH HHS [R01 DK065977] NR 33 TC 18 Z9 20 U1 0 U2 0 PU LANDES BIOSCIENCE PI GEORGETOWN PA 810 SOUTH CHURCH STREET, GEORGETOWN, TX 78626 USA SN 1538-4047 J9 CANCER BIOL THER JI Cancer Biol. Ther. PD JUL PY 2007 VL 6 IS 7 BP 1088 EP 1095 PG 8 WC Oncology SC Oncology GA 229LQ UT WOS:000250805900026 PM 17568188 ER PT J AU Inouye, LS Yoo, LJ Talent, LG Clarke, JU Jones, RP Steevens, JA Boyd, RE AF Inouye, Laura S. Yoo, Leslie J. Talent, Larry G. Clarke, Joan U. Jones, Robert P. Steevens, Jeffery A. Boyd, Robert E. TI Assessment of lead uptake in reptilian prey species SO CHEMOSPHERE LA English DT Article DE lead; trophic transfer; invertebrate; prey; western fence lizard ID METAL; PLASTICITY; ISOPODA AB As part of an investigation determining the trophically available fraction of metals in a model terrestrial food web, i.e., invertebrate prey to Western fence lizards (Sceloporus occidentalis), we evaluated the ability of several invertebrate prey to bioaccumulate lead and to form metals-rich granules, which are hypothesized to be non-available to predators. Crickets (Acheta domestica), tenebroid beetle larvae (Tenebrio molitor), and isopods (Porcellio scaber) were selected as model prey organisms. Lack of standard exposure methodologies for these species has presented a barrier to trophic transfer evaluations, as each species has particular requirements that create challenges for designing exposure conditions. We were able to devise exposure conditions for all three species that allow long-term exposure studies. All prey organisms accumulated lead from contaminated food, and for all species the majority of the accumulated Pb was associated with the exoskeleton (>50%), with metals-rich granules accounting for most of the remaining accumulated lead. Published by Elsevier Ltd. C1 USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. Oklahoma State Univ, Dept Nat Resource Ecol & Management, Stillwater, OK 74078 USA. Specpro, Vicksburg, MS 39180 USA. RP Jones, RP (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Robert.P.Jones@erdc.usace.army.mil NR 10 TC 3 Z9 4 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PD JUL PY 2007 VL 68 IS 8 BP 1591 EP 1596 DI 10.1016/j.chemosphere.2006.12.045 PG 6 WC Environmental Sciences SC Environmental Sciences & Ecology GA 190RM UT WOS:000248076700025 PM 17490716 ER PT J AU Min, S Cole, DM Baker, I AF Min, Song Cole, David M. Baker, Ian TI Effect of fine particles on the flow behavior of polycrystalline ice - (II) anelastic behavior SO CHINESE JOURNAL OF GEOPHYSICS-CHINESE EDITION LA Chinese DT Article DE ice and galciers; anelasticity; relaxation model; flow ID INTERNAL-FRICTION; SALINE ICE; CREEP AB Effects of particles on the anelasticity of polycrystalline ice have been studied by the inverse-direct loading method. The results indicated that at relatively higher frequencies (1 Hz and 10(-1) Hz), anelastic strain has a linear relationship with the stress; and at relatively lower frequency (10(-2) Hz), the stress/strain deviates from linear relationship. Particles have severe influence on the grain boundary relaxation through inhibiting grain boundary sliding at high frequency (1 Hz), and thus increase the modulus and decrease the internal friction. However, particles have no obvious influence on the dislocation relaxation. Two important parameters have been calculated through the anelastic experiments. The results indicated that K value is similar to 0.07 Pa and alpha value is similar to 0.54. C1 Cent S Univ, State Key Lab Powder Met, Changsha 410083, Peoples R China. USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Min, S (reprint author), Cent S Univ, State Key Lab Powder Met, Changsha 410083, Peoples R China. EM josha3508@sina.com RI Song, Min/C-3730-2013 OI Song, Min/0000-0002-3197-4647 NR 19 TC 2 Z9 2 U1 0 U2 4 PU SCIENCE PRESS PI BEIJING PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA SN 0001-5733 J9 CHINESE J GEOPHYS-CH JI Chinese J. Geophys.-Chinese Ed. PD JUL PY 2007 VL 50 IS 4 BP 1156 EP 1160 PG 5 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA 194KO UT WOS:000248343500023 ER PT J AU Davis, DW AF Davis, Darryl W. TI In harm's way SO CIVIL ENGINEERING LA English DT Article C1 USA, Corps Engineers, Inst Water Resources, Alexandria, VA USA. RP Davis, DW (reprint author), USA, Corps Engineers, Inst Water Resources, Alexandria, VA USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD JUL PY 2007 VL 77 IS 7 BP 60 EP 65 PG 6 WC Engineering, Civil SC Engineering GA 190RL UT WOS:000248076500019 ER PT J AU King, CS Zapor, M AF King, Christopher S. Zapor, Michael TI The clinical picture - Bilateral parotitis and facial nerve palsy SO CLEVELAND CLINIC JOURNAL OF MEDICINE LA English DT Editorial Material C1 Walter Reed Army Med Ctr, Pulmonol & Crit Care Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Infect Dis Serv, Washington, DC 20307 USA. RP King, CS (reprint author), Walter Reed Army Med Ctr, Pulmonol & Crit Care Serv, Washington, DC 20307 USA. EM Christopher.king@na.amedd.army.mil NR 5 TC 1 Z9 1 U1 0 U2 0 PU CLEVELAND CLINIC PI CLEVELAND PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA SN 0891-1150 J9 CLEV CLIN J MED JI Clevel. Clin. J. Med. PD JUL PY 2007 VL 74 IS 7 BP 512 EP 513 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 189YW UT WOS:000248025900005 PM 17682628 ER PT J AU Lefkowitz, LJ Kupina, JM Hirth, NL Henry, RM Noland, GY Barbee, JY Zhou, JY Weese, CB AF Lefkowitz, Lee J. Kupina, Joseph M. Hirth, Nigel L. Henry, Rachel M. Noland, Georgia Y. Barbee, John Y., Jr. Zhou, Joey Y. Weese, Coleen B. TI Intraindividual stability of human erythrocyte cholinesterase activity SO CLINICAL CHEMISTRY LA English DT Article ID CELL CHOLINESTERASE; ENZYME-ACTIVITY; BLOOD; INDIVIDUALITY; PLASMA; INDEX; AGE AB Background: Erythrocyte cholinesterase (RBC-ChE) activities serve as useful and sensitive biomarkers to monitor exposure to cholinesterase-inhibiting substances, such as chemical warfare nerve agents and pesticides. Although the interindividual variation of RBC-ChE is well characterized, the magnitude of intraindividual variation for RBC-ChE remains controversial. An accurate measure of intraindividual variation is critical for establishing the appropriate frequency of RBC-ChE testing. Methods: We retrospectively tracked the intraindividual variation of RBC-ChE activities among 46 male nerve agent workers from a single US Army depot that participated in a medical surveillance program requiring periodic RBC-ChE monitoring. All RBC-ChE analysis was performed by the same medical laboratory technician by the delta pH method. Results: A mean of 38 and a median of 37 RBC-ChE measurements were available for each worker. The mean duration of employment for these workers was 20 years (median, 21 years). The mean CV for RBC-ChE in this set of 46 workers was 3.9%. Linear regression analysis of the data for each worker resulted in a mean slope of 0.0010 delta pH units/h per year. Conclusions: RBC-ChE activities increased in each person by a mean of 0.01 delta pH units/h every 10 years, which is a negligible rate. These findings highlight the stability of RBC-ChE activities over time in a given individual and may have important policy implications regarding the appropriate frequency of RBC-ChE testing. (c) 2007 American Association for Clinical Chemistry. C1 USA, Ctr Hlth Promot & Preventat Med, Aberdeen Proving Ground, MD USA. Walter Reed Army Inst Res, Silver Spring, MD USA. USA, Occupat Hlth Clin, Bluegrass Army Depot, Richmond, KY USA. RP Weese, CB (reprint author), USA, Ctr Hlth Promot & Preventat Med, 5158 Blackhawk Rd,Aberdeen Proving Ground, Aberdeen Proving Ground, MD USA. EM coleen.weese@us.army.mil NR 28 TC 11 Z9 12 U1 0 U2 4 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUL PY 2007 VL 53 IS 7 BP 1358 EP 1363 DI 10.1373/clinchem.2006.085258 PG 6 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 183FL UT WOS:000247558000026 PM 17495017 ER PT J AU Paolino, K Erwin, D Padharia, V Carrero, H Giron, L Burgess, R Burger, C Martinez, M Arrieta, P Wortmann, G Zapor, M AF Paolino, Kris Erwin, Daniel Padharia, Vanaja Carrero, Hector Giron, Lizzette Burgess, Robert Burger, Chad Martinez, Maria Arrieta, Patricia Wortmann, Glenn Zapor, Michael TI In vitro activity of colistin against multidrug-resistant gram-negative bacteria isolated at a major army hospital during the military campaigns in Iraq and Afghanistan SO CLINICAL INFECTIOUS DISEASES LA English DT Letter C1 Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Clin Microbiol Lab, Washington, DC 20307 USA. RP Zapor, M (reprint author), Walter Reed Army Med Ctr, Infect Dis Serv, 6900 Georgia Ave, Washington, DC 20307 USA. EM michael.zapor@amedd.army.mil RI Paolino, Kristopher/G-1859-2012 NR 3 TC 8 Z9 8 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL 1 PY 2007 VL 45 IS 1 BP 140 EP 141 DI 10.1086/520486 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 175RC UT WOS:000247029700031 PM 17554723 ER PT J AU Patel, PK Novia, MV AF Patel, Pravin K. Novia, Michael V. TI The surgical tools: The LeFort I, bilateral sagittal split osteotomy of the mandible, and the osseous genioplasty SO CLINICS IN PLASTIC SURGERY LA English DT Article AB Orthognathic surgery involves the surgical manipulation of the elements of the facial skeleton to restore normal anatomic and functional relationships in patients who have dentofacial skeletal anomalies. The elements of the facial skeleton can be repositioned, redefining the face through a variety of well-established osteotomies. Most maxillofacial deformities can be managed with the three basic osteotomies discussed in this article: the LeFort I type osteotomy, the bilateral sagittal split osteotomy of the mandibular ramus, and the horizontal osteotomy of the symphysis of the chin (osseous genioplasty). C1 Shriners Hosp Children, Chicago, IL 60707 USA. Univ Illinois, Med Ctr, Chicago, IL USA. Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. USA, Fort Lewis, WA USA. Madigan Army Med Ctr, Fort Lewis, WA USA. Univ Illinois, Childrens Mem Hosp, Div Pediat Plast Surg, Chicago, IL 60680 USA. RP Patel, PK (reprint author), Shriners Hosp Children, Chicago, IL 60707 USA. EM pkpatelmd@mac.com NR 21 TC 16 Z9 17 U1 1 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0094-1298 J9 CLIN PLAST SURG JI Clin. Plast. Surg. PD JUL PY 2007 VL 34 IS 3 BP 447 EP + DI 10.1016/j.cps.2007.05.012 PG 30 WC Surgery SC Surgery GA 208TJ UT WOS:000249341800010 PM 17692704 ER PT J AU Abdel-Malek, K AF Abdel-Malek, Karim TI Human modeling and applications special issue SO COMPUTER-AIDED DESIGN LA English DT Editorial Material C1 Univ Iowa, Dept Mech Engn, US Army Virtual Soldier Res Program, Ctr Comp Aided Design, Iowa City, IA 52242 USA. RP Abdel-Malek, K (reprint author), Univ Iowa, Dept Mech Engn, US Army Virtual Soldier Res Program, Ctr Comp Aided Design, Iowa City, IA 52242 USA. EM amalek@engineering.uiowa.edu NR 0 TC 2 Z9 3 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0010-4485 J9 COMPUT AIDED DESIGN JI Comput.-Aided Des. PD JUL PY 2007 VL 39 IS 7 BP 539 EP 539 DI 10.1016/j.cad.2007.04.001 PG 1 WC Computer Science, Software Engineering SC Computer Science GA 190RE UT WOS:000248075800001 ER PT J AU Lewis, MFS Smith, LJ AF Lewis, Maj Felisa S. Smith, Laurie J. TI What's eating you? Bees, part 2: Venom immunotherapy and mastocytosis SO CUTIS LA English DT Article ID INSECT STING ALLERGY; MAST-CELL TRYPTASE; NATURAL-HISTORY; SERUM TRYPTASE; SYSTEMIC MASTOCYTOSIS; HYMENOPTERA STINGS; ANAPHYLAXIS; SENSITIVITY; SEVERITY; DIAGNOSIS AB Bee stings are common in the United States. In part 1 of this series, we reviewed the characteristics of bumblebees, honeybees, and Africanized honeybees; the types and pathophysiology of sting reactions; and the medical management and prevention of bee stings. In this article, we review the concepts and practice of venom immunotherapy. We further discuss the diagnosis of systemic mastocytosis, initially presenting as anaphylaxis, and the efficacy of immunotherapy in patients with mastocytosis. C1 Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC USA. RP Lewis, MFS (reprint author), 231 Little Quarry Rd, Gaithersburg, MD 20878 USA. EM felisa.lewis@na.amedd.army.mil NR 40 TC 0 Z9 0 U1 0 U2 1 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD JUL PY 2007 VL 80 IS 1 BP 33 EP 37 PG 5 WC Dermatology SC Dermatology GA 198CG UT WOS:000248604000005 ER PT J AU Page, JM Vinson, SL Jones, DP AF Page, John M. Vinson, Sidney L. Jones, David P. TI Complex pancreatic duct stricture with stone versus partial pancreas divisum - A therapeutic dilemma SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE pancreatic duct stone; pancreas divisum; pancreatitis; endoscopic retrograde cholangiopancreatography; extracorporeal shock wave lithotripsy ID SHOCK-WAVE LITHOTRIPSY; DRAINAGE; PAIN C1 Brooke Army Med Ctr, Dept Internal Med, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA. RP Page, JM (reprint author), Brooke Army Med Ctr, Dept Internal Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM PageJM@amedd.army.mil NR 17 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD JUL PY 2007 VL 52 IS 7 BP 1621 EP 1626 DI 10.1007/s10620-005-9001-4 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 180PV UT WOS:000247378900003 PM 17091390 ER PT J AU Song, JW Baek, LJ Schmaljohn, CS Yanagihara, R AF Song, Jin-Won Baek, Luck Ju Schmaljohn, Connie S. Yanagihara, Richard TI Thottapalayam virus, a prototype shrewborne hantavirus SO EMERGING INFECTIOUS DISEASES LA English DT Article ID KOREAN HEMORRHAGIC-FEVER; RENAL SYNDROME HFRS; NEPHROPATHIA-EPIDEMICA VIRUS; HANTAAN-VIRUS; ETIOLOGIC AGENT; FAMILY BUNYAVIRIDAE; EXPERIMENTAL-INFECTION; BETA(3) INTEGRINS; CELLULAR ENTRY; EUROPEAN USSR AB Thottapalayam virus (TPMV) has been placed in the genus Hantavirus of the family Bunyaviridae by virtue of its morphologic features and overall genetic similarities to well-characterized rodentborne hantaviruses. This virus has been isolated from the Asian house shrew (Suncus murinus); however, whether TPMV is naturally harbored by an insectivore host or represents spillover from a rodent reservoir host is unknown. Our analysis of published and unpublished data on the experimental host range, genetics, and molecular phylogeny of TPMV supports coevolution of TPMV with its nonrodent reservoir host. Future studies on the epizootiology of TPMV and investigations of new shrew-borne hantaviruses will provide additional insights into the evolutionary origin of hantaviruses in their rodent and insectivore reservoir hosts. Such investigations may also provide clues about determinants of hantavirus pathogenicity and virulence. C1 Univ Hawaii Manoa, Pacific Ctr Emerging Infect Dis Res, John A Burns Sch Med, Honolulu, HI 96813 USA. Korea Univ, Coll Med, Seoul 136701, South Korea. USA, Med Res Inst Infect Dis, Frederick, MD USA. RP Yanagihara, R (reprint author), Univ Hawaii Manoa, Pacific Ctr Emerging Infect Dis Res, John A Burns Sch Med, 651 Ilalo St,BSB 320L, Honolulu, HI 96813 USA. EM yanagiha@pbrc.hawaii.edu FU NCRR NIH HHS [P20RR018727, P20 RR018727, P20 RR018727-05] NR 40 TC 56 Z9 58 U1 1 U2 2 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD JUL PY 2007 VL 13 IS 7 BP 980 EP 985 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 186DB UT WOS:000247758200003 PM 18214168 ER PT J AU Johnson, MS Quinn, MJ Bazar, MA Gust, KA Escalon, BL Perkins, EJ AF Johnson, Mark S. Quinn, Michael J. Bazar, Matthew A. Gust, Kurt A. Escalon, B. Lynn Perkins, Edward J. TI Subacute toxicity of oral 2,6-dinitrotoluene and 1,3,5-trinitro-1,3,5-triazine (RDX) exposure to the northern bobwhite (Colinus virginianus) SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE birds; bobwhite; dinitrotoluene; energetics; explosives ID STAGEWISE AB Military activities associated with training have resulted in soil residues of munition compounds and their breakdown products. Often, these areas are valuable habitats used by birds. To evaluate the possibility of adverse effects in birds, the effects from oral exposures of 2,6-dinitrotoluene (2,6-DNT) and 1,3,5-trinitro-1,3,5-triazine (RDX) were tested using a controlled dosing regime in northern bobwhite (Colinus virginianus). Nine groups of birds of mixed sex received either corn oil or 50, 100, 190, or 350 mg 2,6-DNT/kg body weight/d or 20, 80, 125, or 180 mg RDX/kg body weight/d mixed in corn oil via gavage for 14 d. Etiology of disease was markedly different between compounds. Increased RDX exposure caused an inverse relationship to time of death, symptoms including clonic followed by tonic convulsions, and death shortly thereafter. Brain concentrations of RDX postmortem, however, were relatively consistent (mean +/- standard error, 20.5 +/- 2.9 mg/kg tissue). Observations of 2,6-DNT effects included gastrointestinal distress, dehydration, and a reduction in body mass and feed consumption. Together, these data suggest that RDX is more toxic from short, repeated exposures than 2,6-DNT, resulting in central nervous system-related effects, whereas 2,6-DNT causes gastrointestinal disturbances at higher exposures. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. SpecPro, Vicksburg, MS 39108 USA. USA, Ctr Res Dev & Engn, Vicksburg, MS 39108 USA. RP Johnson, MS (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. EM mark.s.johnson@us.army.mil NR 22 TC 19 Z9 21 U1 0 U2 3 PU SOCIETY ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD JUL PY 2007 VL 26 IS 7 BP 1481 EP 1487 DI 10.1897/06-525.1 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 180PY UT WOS:000247379200020 PM 17665690 ER PT J AU Li, Q Liu, D Templeton, D Raju, B AF Li, Q. Liu, D. Templeton, D. Raju, B. TI A shock tube-based facility for impact testing SO EXPERIMENTAL TECHNIQUES LA English DT Article C1 Michigan State Univ, Dept Mech Engn, E Lansing, MI 48824 USA. USA, RDECOM, TARDEC, Warren, MI USA. RP Li, Q (reprint author), Michigan State Univ, Dept Mech Engn, E Lansing, MI 48824 USA. NR 6 TC 2 Z9 2 U1 0 U2 1 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0732-8818 J9 EXP TECHNIQUES JI Exp. Tech. PD JUL-AUG PY 2007 VL 31 IS 4 BP 25 EP 28 DI 10.1111/j.1747-1567.2007.00156.x PG 4 WC Engineering, Mechanical; Mechanics; Materials Science, Characterization & Testing SC Engineering; Mechanics; Materials Science GA 198AY UT WOS:000248600600004 ER PT J AU Parker, JD Malik, M Catherino, WH AF Parker, Jason D. Malik, Minnie Catherino, William H. TI Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor SO FERTILITY AND STERILITY LA English DT Article DE GnRH2 and GnRHR2; microarray analysis; RT-PCR; real-time RT-PCR; western blot; immunohistochemistry ID GONADOTROPIN-RELEASING-HORMONE; SMOOTH-MUSCLE-CELLS; RECEPTOR GENE-EXPRESSION; AUTOCRINE GROWTH-FACTOR; GNRH-II; UTERINE LEIOMYOMAS; GYNECOLOGICAL CANCERS; ENDOMETRIAL CANCER; MENSTRUAL-CYCLE; ANALOG THERAPY AB Objective: To determine the presence or absence of a second form of GnRH (GnRH2) and corresponding receptor (GnRHR2) in human uterine myometrium and leiomyomata. Design: Evaluation of human leiomyoma and patient-matched myometrium of differential mRNA and protein expression of GnRH2 and GnRHR2. Setting: University hospital. Patient(S): Eight women undergoing medically indicated hysterectomy for symptomatic fibroids. Intervention(s): Microarray analysis, reverse-transcriptase polymerase chain reaction (RT-PCR), real-time RTPCR, and immunohistochemistry. Main Outcome Measure(s): Expression of mRNA and protein in leiomyoma and patient-matched myometrium. Result(s): Microarray analysis demonstrated expression, and we confirmed the findings by RT-PCR. Real-time RT-PCR demonstrated equivalent expression of the genes in leiomyoma compared with patient-matched myometrium (0.99-fold for GnRH2 and 1.28-fold for GnRHR2). lmmunohistochemistry confirmed the expression of GnRH2 protein in both leiomyoma and myometrium. Conclusion(S): A second form of GnRH and corresponding receptor exists in the fibroid and myometrium. We speculate that an autocrine loop exists. Our findings provide further evidence that GnRH agonists may interact directly with GnRH receptors present in uterine fibroids. C1 NICHHD, Reprod Biol & Med Branch, NIH, Bethesda, MD 20892 USA. Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Catherino, WH (reprint author), Uniformed Serv Univ Hlth Sci, Dept Obstet & Gynecol, Bldg A,Room 3078,4301 Jones Bridge Rd, Bethesda, MD 20814 USA. EM catheriw@mail.nih.gov OI Malik, Minnie/0000-0003-1129-6575 FU Intramural NIH HHS NR 51 TC 11 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JUL PY 2007 VL 88 IS 1 BP 39 EP 46 DI 10.1016/j.fertnstert.2006.11.098 PG 8 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 190JC UT WOS:000248054100006 PM 17296196 ER PT J AU McWilliams, GDE Frattarelli, JL AF McWilliams, Grant D. E. Frattarelli, John L. TI Changes in measured endometrial thickness predict in vitro fertilization success SO FERTILITY AND STERILITY LA English DT Article DE infertility; endometrial thickness; endometrial growth; transvaginal ultrasound; pregnancy outcome; IVF; endometrium; implantation ID ASSISTED REPRODUCTION; INVITRO FERTILIZATION; OVARIAN STIMULATION; PREGNANCY RATES; EMBRYO IMPLANTATION; PATTERN; APPEARANCE; INJECTION; WOMEN AB Objective: To assess the predictive ability of endometrial thickness and changes in endometrial thickness on pregnancy outcomes in patients undergoing IVF. Design: Retrospective cohort analysis. Setting: Academic IVF center. Patient(s): Infertile patients undergoing 132 fresh autologous IVF cycles. Intervention(s): Transvaginal ultrasound to assess endometrial thickness at three defined points during IVF (after pituitary suppression, on the sixth day of gonadotropin stimulation, and on the day of hCG administration). Main Outcome Measure(s): Primary outcome variables included endometrial lining thickness at baseline, on day 6 of gonadotropins, the day of hCG administration, and the change in endometrial thickness during gonadotropin stimulation. Result(s): Patients attaining pregnancy had significantly greater endometrial thickness on day 6 and endometrial thickness on day of hCG administration. Pregnant patients had a greater change in endometrial thickness from the baseline to day 6 when compared to nonpregnant patients. Threshold analysis and receiver-operator characteristic curves noted significant endometrial thickness levels for implantation and pregnancy rates. Conclusion(s): Endometrial responsiveness and thickness during the early IVF stimulation seem to be better prognostic predictors of success than endometrial thickness at the start or the end of the IVF cycle. C1 Reprod Med Associates New Jersey, Somerset, NJ 08873 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Frattarelli, JL (reprint author), Reprod Med Associates New Jersey, 100 Franklin Sq Dr,Suite 200, Somerset, NJ 08873 USA. EM jfrattarelli@rmanj.com NR 18 TC 33 Z9 44 U1 3 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JUL PY 2007 VL 88 IS 1 BP 74 EP 81 DI 10.1016/j.fertnstert.2006.11.089 PG 8 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA 190JC UT WOS:000248054100011 PM 17239871 ER PT J AU Lee, LT Freeman, RB AF Lee, Landris T., Jr. Freeman, Reed B. TI An alternative test method for assessing consistency limits SO GEOTECHNICAL TESTING JOURNAL LA English DT Article DE fall cone penetrometer; Atterberg limits; linear shrinkage ID FALL-CONE; PLASTIC LIMIT; LIQUID LIMIT; SOILS; PENETROMETER; CLAYS AB Experiments were conducted to assess simpler alternatives for estimating the Atterberg (liquid and plastic) limits as needed during military field reconnaissance and combat engineering exercises. Eight non-ASTM test methods were compared to the Casagrande cup liquid limit method and ten non-ASTM alternatives were compared to the rolled-bead plastic limit method for three cohesive soils having wide plasticity index ranges. Only one non-ASTM method yielded results within 10 % of the ASTM liquid and plastic limit values. This unique test method was created from a unified (dual-weight) fall cone apparatus and procedure to enable simple assessment of soil consistency limits. C1 USA, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. RP Lee, LT (reprint author), USA, Ctr Res Dev & Engn, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 38 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 USA SN 0149-6115 J9 GEOTECH TEST J JI Geotech. Test. J. PD JUL PY 2007 VL 30 IS 4 BP 274 EP 281 PG 8 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA 188SL UT WOS:000247939500004 ER PT J AU Outing, DA Siegmann, WL Collins, MD AF Outing, Donald A. Siegmann, William L. Collins, Michael D. TI Scholte-to-Rayleigh conversion and other effects in range-dependent elastic media SO IEEE JOURNAL OF OCEANIC ENGINEERING LA English DT Article DE interface waves; parabolic equation method; range dependence; seismoacoustics ID CONSERVING PARABOLIC EQUATION; WAVE-PROPAGATION; SLOPING INTERFACES; OCEAN; GUIDES AB The parabolic equation method provides an excellent combination of accuracy and efficiency for range-dependent ocean-acoustics and seismology problems. This approach is highly developed for problems in which the ocean bottom can be modeled as a fluid. For the elastic case, there remain accuracy limitations for problems involving sloping interfaces. Progress on this problem is achieved by improving and benchmarking the mapping solution. This approach is extended to handle multiple solid layers and propagation between sea and land. It is applied to new types of problems, such as the propagation of a Scholte wave up a eloping ocean bottom and conversion to a Rayleigh wave on land. Although the available benchmark solutions are limited, the results indicate that the mapping solution should be accurate for a large class of problems when slopes are small and that this assumption can be relaxed by applying a simple correction. C1 [Outing, Donald A.; Siegmann, William L.] Rensselaer Polytech Inst, Troy, NY 12180 USA. [Collins, Michael D.] Naval Res Lab, Washington, DC 20375 USA. RP Outing, DA (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM collins@noddy.nrl.navy.mil NR 19 TC 5 Z9 5 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0364-9059 J9 IEEE J OCEANIC ENG JI IEEE J. Ocean. Eng. PD JUL PY 2007 VL 32 IS 3 BP 620 EP 625 DI 10.1109/JOE.2007.902785 PG 6 WC Engineering, Civil; Engineering, Ocean; Engineering, Electrical & Electronic; Oceanography SC Engineering; Oceanography GA 257QZ UT WOS:000252814900008 ER PT J AU Akturk, A Pennington, G Goldsman, N Wickenden, A AF Akturk, Akin Pennington, Gary Goldsman, Neil Wickenden, Alma TI Electron transport and velocity oscillations in a carbon nanotube SO IEEE TRANSACTIONS ON NANOTECHNOLOGY LA English DT Article DE carbon nanotubes; electron transport; Monte Carlo methods; terahertz oscillations ID PHONON-SCATTERING; MONTE-CARLO; TRANSISTORS; MOBILITY AB We report Monte Carlo (MC) simulation results showing applied bias dependent spatial velocity oscillations for semiconducting single-walled zig-zag carbon nanotubes (CNTs). MC simulations show velocity oscillations in CNTs at different lengths due to high scattering rates associated with optical phonon emissions in the one-dimensional CNT system. The frequencies of these oscillations are as high as 30 THz. In addition, we investigate average ensemble electron velocities as a function of tube length. C1 Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. Army Res Lab, Adelphi, MD 20793 USA. RP Akturk, A (reprint author), Univ Maryland, Dept Elect & Comp Engn, College Pk, MD 20742 USA. EM akturka@umd.edu NR 27 TC 33 Z9 34 U1 0 U2 7 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1536-125X J9 IEEE T NANOTECHNOL JI IEEE Trans. Nanotechnol. PD JUL PY 2007 VL 6 IS 4 BP 469 EP 474 DI 10.1109/TNANO.2007.896968 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Science & Technology - Other Topics; Materials Science; Physics GA 191BV UT WOS:000248105700011 ER PT J AU Venkitasubramaniam, P Tong, L Swami, A AF Venkitasubramaniam, Parvathinathan Tong, Lang Swami, Ananthram TI Quantization for maximin ARE in distributed estimation SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article; Proceedings Paper CT IEEE International Conference on Acoustics, Speech and Signal Processing CY MAY 14-19, 2006 CL Toulouse, FRANCE SP IEEE Signal Proc Soc DE asymptotic relative efficiency (ARE); distributed estimation; quantization; score-function quantizer (SFQ) ID DECENTRALIZED ESTIMATION; DATA-COMPRESSION; INFORMATION; QUANTIZERS AB We consider the design of optimal quantizers for the distributed estimation of a deterministic parameter. In particular, we design deterministic scalar quantizers to maximize the minimum asymptotic relative efficiency (ARE) between quantized and unquantized ML estimators. We first design identical quantizers using the class of score-function quantizers (SFQ). We show that the structure of SFQs generally depend on the parameter value, but can be expressed as thresholds on the sufficient statistic for a large class of distributions. We provide a convergent iterative algorithm to obtain the best SFQ that maximizes the minimum ARE for distributions of that class. We compare the performance of the optimal SFQ with a general quantizer designed without making any restrictions on the structure. This general quantizer is hard to implement due to lack of structure, but is optimal if the iterative design algorithm does not encounter local minima. Through numerical simulations, we illustrate that the two quantizers designed are identical. In other words, the optimal quantizer structure is that of an SFQ. For a distributed estimation setup, designing identical quantizers is shown to be suboptimal. We, therefore, propose a joint multiple quantizer design algorithm based on a person-by-person optimization technique employing the SFQ structure. Using numerical examples, we illustrate the gain in performance due to designing nonidentical quantizers. C1 Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. US Army Res Lab, Adelphi, MD 20783 USA. RP Venkitasubramaniam, P (reprint author), Cornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA. EM pv45@comell.edu; lt35@comell.edu; a.swami@ieee.org NR 16 TC 26 Z9 27 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD JUL PY 2007 VL 55 IS 7 BP 3596 EP 3605 DI 10.1109/TSP.2007.894279 PN 2 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA 182EW UT WOS:000247488900005 ER PT J AU Kim, J Hobbs, BF Koonce, JF AF Kim, Jongbum Hobbs, Benjamin F. Koonce, Joseph F. TI Analysis of the sensitivity of decision analysis results to errors and simplifications in problem structure: Application to Lake Erie ecosystem management SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS PART A-SYSTEMS AND HUMANS LA English DT Article DE Bayesian decision analysis; decision trees; Lake Erie ecosystem; multidimensional cubic spline; subjective judgments ID RECOVERY AB In practical decision analyses, the "curse of dimensionality" compels one to make simplifying assumptions that can introduce errors into estimates of various indexes that interest decision-makers. These indexes include the expected performance of optimal and suboptimal strategies, the benefit 'of explicitly considering uncertainty, and the benefit of additional information. This paper quantifies the effects on these indexes of simplifying assumptions, including discretization of the decision space, omission of some decision variables and uncertainties from the decision tree, and disregarding of risk aversion. To reduce errors arising from discretization of the decision space, we use a multidimensional cubic spline to interpolate the performance of alternatives between a few simulated points. A case study analyzes decisions concerning phosphorus loading, fisheries management, and lower trophic research projects in Lake Erie under multiple criteria and ecological uncertainties. Results show that spline-based solutions often yield potentially superior decisions from those based on discretized decision spaces, but that omitting important uncertainties makes more of a difference in this case study's decisions and indexes than simplifying the decision space. On the other hand, incorrect multicriteria weights affect the case study's outcomes more than incorrect probabilities. C1 Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA. Case Western Reserve Univ, Dept Biol, Cleveland, OH 44106 USA. RP Kim, J (reprint author), USA, Ctr Res Dev & Engn, Waterways Expt Stn, Vicksburg, MS 39180 USA. EM Jongbum.Kim@erdc.usace.army.mil; bhobbs@jhu.edu; jfk7@po.cwru.edu RI Hobbs, Benjamin/A-3291-2010 NR 23 TC 1 Z9 1 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1083-4427 J9 IEEE T SYST MAN CY A JI IEEE Trans. Syst. Man Cybern. Paart A-Syst. Hum. PD JUL PY 2007 VL 37 IS 4 BP 505 EP 518 DI 10.1109/TSMCA.2007.897708 PG 14 WC Computer Science, Cybernetics; Computer Science, Theory & Methods SC Computer Science GA 180UB UT WOS:000247390500006 ER PT J AU Glaser, D Bridges, TS AF Glaser, David Bridges, Todd S. TI Separating the Wheat from the Chaff: The Effective Use of Mathematical Models as Decision Tools SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT LA English DT Article DE Modeling; Risk assessment; Contaminated sediments; Validation; Uncertainty AB The purpose of this paper is to discuss the effective use of quantitative modeling in environmental decision making, with a particular focus on problems of contaminated sediment and surface water. The intended audience includes both model developers and model users. Our goal is to facilitate more effective communication among model developers and those using the information produced by models to aid decision making. We provide a series of observations or conclusions we have reached in our experience that are as follows. A model is a tool for evaluating alternate hypotheses; a model itself is not a hypothesis. All decisions are actually based upon models, either explicitly or implicitly. Models are used to address diagnostic and prognostic questions. Models can provide value added when applied throughout the lifetime of a project. Uncertainty, and therefore the need for models, is greater in systems near background. Models can provide useful information even when based on relatively small data sets. The utility of a model depends on the strength of the constraints placed upon it. The calibration process can be only partially specified a priori. Model calibration and evaluation require multiple lines of evidence. Uncertainty analysis is both qualitative and quantitative. Validation is provided by the application of the model under a wide range of conditions. Communication of the strength of model constraints is critical to model acceptance. We conclude that while models are often used in the evaluation of contaminated sediment problems, distrust in the use of models remains strong. The assessment of uncertainty is the factor most limiting acceptability. C1 [Glaser, David] Quantitat Environm Anal, 305 West Grand Ave, Montvale, NJ 07645 USA. [Bridges, Todd S.] US Army Engn Res & Dev Ctr, Waterways Expt Stn, Vicksburg, MS 39180 USA. RP Glaser, D (reprint author), Quantitat Environm Anal, 305 West Grand Ave, Montvale, NJ 07645 USA. EM dglaser@qeallc.com NR 24 TC 6 Z9 7 U1 0 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1551-3777 EI 1551-3793 J9 INTEGR ENVIRON ASSES JI Integr. Environ. Assess. Manag. PD JUL PY 2007 VL 3 IS 3 BP 442 EP 449 DI 10.1002/ieam.5630030313 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA V43WZ UT WOS:000209712800014 PM 17695115 ER PT J AU Iyer, KA AF Iyer, Kaushik A. TI Relationships between multiaxial stress states and internal fracture patterns in sphere-impacted silicon carbide SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article DE Hertz; impact; internal macrocracks; conoid; distributed microcracks; LEFM ID CONE CRACKS; HERTZIAN FRACTURE; BRITTLE SOLIDS; INDENTATION; PROPAGATION; ALGORITHM; FAILURE AB Internal fracture patterns developed in silicon carbide cylindrical targets as a result of dynamic indentation (63-500m/s) by tungsten carbide spheres are defined. Microscopy of recovered and sectioned targets delineate into three regions, each associated with distinct cracking modes, i.e., shallow cone macrocracking at and near the impact surface, steep interior cone macrocracks that radiate into the target from the impact region and local grain-scale microcracking directly underneath the impact region. The observed fracture patterns are found to maintain a noticeable degree of self-similarity upto the impact velocity of 500 m/s. Linear elastic analysis of the full (surface and interior) stress field developed under static (Hertz) contact loading delineate the target into four regions, based on the number of principal stresses that are tensile (none, 1, 2 or all 3). A strong correlation is found between the principal stress conditions within each region and the forms of cracking, their locations and orientations present therein. This correlation has a number of implications, including non-interaction of crack systems, which are discussed. Illustrative linear elastic fracture mechanics analyses are performed for three regions, and calculated and observed macrocrack lengths are found to be in reasonable agreement. C1 USA, Res Lab, AMSRD ARL WM TD, Aberdeen Proving Ground, MD 21005 USA. RP Iyer, KA (reprint author), Exponent Failure Anal Associates Inc, Menlo Pk, CA 94025 USA. EM kiyer@exponent.com RI Iyer, Kaushik/H-1411-2016 NR 28 TC 12 Z9 14 U1 0 U2 6 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0376-9429 EI 1573-2673 J9 INT J FRACTURE JI Int. J. Fract. PD JUL PY 2007 VL 146 IS 1-2 BP 1 EP 18 DI 10.1007/s10704-007-9108-z PG 18 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA 241VA UT WOS:000251682700001 ER PT J AU Owens, B Mountcastle, S White, D AF Owens, B. Mountcastle, S. White, D. TI Racial differences in tendon rupture incidence SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE military; epidemilogy; tendon ID ABO BLOOD-GROUPS; MUSCULOSKELETAL INJURIES; UNITED-STATES; OVERWEIGHT; SPORTS; AGE AB Despite some anecdotal evidence, the racial differences in tendon injuries have received little attention in the literature. We sought to determine the effect of race on major tendon injuries. A search was performed according to the International Classification of Diseases, Ninth Revision, Clinical Modification code 727.65 (rupture of quadriceps tendon), 727.66 (rupture of patellar tendon), and 727.67 (rupture of Achilles tendon) using the U.S. Defense Medical Epidemiology Database (DMED). Multivariate poisson regression was used to estimate the rate of major tendon rupture per 1000 person-years, while controlling for differences in gender, service, rank, and age for each code. We computed rate ratios and 95% confidence intervals using whites as the referent category. The adjusted rate ratio for black service members when compared to white service members was 2.89 (95% Cl 2.42, 3.44) for quadriceps tendon tears, 4.52 (95% Cl 3.94, 5.19) for patellar tendon tears, and 3.58 (95% CI 3.31, 3.88) for Achilles tendon tears. There appears to be a significant relative predisposition toward lower-extremity major tendon rupture in black U.S. service members when compared to white service members. Investigation of the racial differences in risk factors is warranted. C1 Keller Army Hosp, Dept Orthopaed Surg, West Point, NY 10996 USA. Keller Army Hosp, Dept Orthopaed Res, West Point, NY USA. Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI USA. RP Owens, B (reprint author), Keller Army Hosp, Dept Orthopaed Surg, West Point, NY 10996 USA. EM b.owens@us.army.mil NR 17 TC 25 Z9 26 U1 0 U2 1 PU GEORG THIEME VERLAG KG PI STUTTGART PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD JUL PY 2007 VL 28 IS 7 BP 617 EP 620 DI 10.1055/s-2007-964837 PG 4 WC Sport Sciences SC Sport Sciences GA 192CZ UT WOS:000248179700013 PM 17357966 ER PT J AU Larsen, WI Yavorek, T AF Larsen, W. I. Yavorek, Trudy TI Pelvic prolapse and urinary incontinence in nulliparous college women in relation to paratrooper training SO INTERNATIONAL UROGYNECOLOGY JOURNAL LA English DT Article; Proceedings Paper CT Joint Annual Meeting of the American-Urogynecologic-Society/Society-of-Gynecologic-Surgeons CY JUL 29-31, 2004 CL San Diego, CA SP Amer Urogynecol Soc, Soc Gynecol Surg DE incontinence; nulliparous; paratrooper training; pelvic organ prolapse ID ORGAN PROLAPSE AB The objective of this study was to determine whether paratrooper training is associated with pelvic support defects or urinary incontinence. Nulliparous women at The United States Military Academy were examined using the Pelvic Organ Prolapse Quantification System and completed a questionnaire regarding incontinence and exercise prior to undergoing summer military training. The exam and questionnaire were repeated following training. One hundred sixteen women completed the study (80.6%), 37 of whom had attended paratrooper training. Women who attended paratrooper training were significantly more likely to have stage II prolapse (RR=2.72, 1.37 5% body mass. The IGF-I system is an important adjunct in the overall assessment of adaptation to stress imposed by high levels of physical activity superimposed on energy and sleep restriction and is more closely associated with losses in body mass and fat-free mass than other conventional nutritional biomarkers. C1 USA, Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. USA, Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA. Pennington Biomed Res Ctr, Clin Res Lab, Baton Rouge, LA 70808 USA. RP Nindl, BC (reprint author), USA, Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA. EM Bradley.Nindl@na.amedd.army.mil OI Kellogg, Mark/0000-0003-1868-2153 NR 32 TC 33 Z9 33 U1 1 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 2007 VL 103 IS 1 BP 340 EP 346 DI 10.1152/japplphysiol.01321.2006 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 195KK UT WOS:000248410900044 PM 17412783 ER PT J AU Poovey, AG Slade, JG Netherland, MD AF Poovey, Angela G. Slade, Jeremy G. Netherland, Michael D. TI Susceptibility of Eurasian watermilfoil (Myriophyllum spicatum) and a milfoil hybrid (M. spicatum x M. sibiricum) to Triclopyr and 2,4-D amine SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article DE submersed aquatic macrophyte; auxin analog herbicide; chemical control; dose-response ID FRESH-WATER MACROPHYTES; RICE ORYZA-SATIVA; EUHRYCHIOPSIS-LECONTEI; BIOLOGICAL-CONTROL; HERBICIDE RESISTANCE; WEED MANAGEMENT; GENE FLOW; HYBRIDIZATION; WEEVIL; TEMPERATURE AB Hybridization of the exotic Eurasian watermilfoil (Myriophyllum spicatum L.) with the native northern watermilfoil (M. sibiricum Komarov) has been verified in the Great Lake and Pacific Northwest regions. To determine if a milfoil hy brid was susceptible to aquatic herbicides typically used to control Eurasian watermilfoil, we conducted a small-scale experiment evaluating the comparative response of M. spicatum X M. sibiricum and its parental species, M. spicatum, to 2,4-D (2,4-dichlorophenoxyacetic acid) and triclopyr (3,5,6-trichloro-2-pyridinyloxyacetic acid). Plants were field collected from Minnesota, grown in 48-L aquaria, then dosed with 0.01, 0.03, 0.09, 0.27, 0.81, 2.43 acid equivalent (ae) 2,4-D amine and triclopyr for an exposure time of 24 to 28 It. The dose that caused a 50% growth reduction (GR(50)) in shoot length was calculated from dose-response curves for each herbicide. For triclopyr, the GR(50) (+/- 1 SE) for Eurasian watermilfoil was 0.04 0.01 mg ae L-1, while the GR(50) for the milfoil hybrid was 0.08 +/- 0.01 mg ae L-1. For 2,4-D amine, the GR(50) for the Eurasian enotype was 0. 11 +/- 0.02 ing ae L-1 while the GR(50) for the 9 +/- 50 hybrid was 0.12 +/- 0.02 ing ae L-1. Rates of >= 0.27 mg ae L-1 triclopyr or 2,4-D amine were effective in reducing shoot biomass by 95 to 100% for both the Eurasian and hybrid milfoils. This initial study showed that Eurasian watermilfoil and the milfoil hybrid responded similarly to the herbicides tested. Additional testing of different milfoil hybrid accessions should be conducted to determine the roles genotypic variation, environmental factors, and plant vigor may play in the operational chemical control of milfoil species. C1 USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. Mississippi State Univ, Dept Wildlife & Fisheries, Mississippi State, MS 39762 USA. USA, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. RP Poovey, AG (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. NR 35 TC 8 Z9 8 U1 5 U2 30 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2007 VL 45 BP 111 EP 115 PG 5 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 225SD UT WOS:000250536800007 ER PT J AU Slade, JG Poovey, AG Netherland, MD AF Slade, Jeremy G. Poovey, Angela G. Netherland, Michael D. TI Efficacy of fluridone on Eurasian and hybrid watermilfoll SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID HERBICIDE RESISTANCE; EVOLUTION; HYDRILLA; HYBRIDIZATION; POPULATIONS; PLANTS C1 Mississippi State Univ, Dept Wildlife & Fisheries, Mississippi State, MS 39762 USA. USA, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Gainesville, FL 32653 USA. USA, Engn Res & Dev Ctr, Ctr Aquat & Invas Plants, Vicksburg, MS 39180 USA. RP Slade, JG (reprint author), Mississippi State Univ, Dept Wildlife & Fisheries, Box 9690, Mississippi State, MS 39762 USA. NR 17 TC 5 Z9 5 U1 0 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2007 VL 45 BP 116 EP 118 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 225SD UT WOS:000250536800008 ER PT J AU Glomski, LM Netherland, MD AF Glomski, Leeann M. Netherland, Michael D. TI Efficacy of diquat and carfentrazone-ethyl on variable-leaf milfoil SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Article ID MACROPHYTES; TURBIDITY; ENDOTHALL; WEEDS C1 SpecPro Inc, USA, Army Engn Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX 75057 USA. USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Glomski, LM (reprint author), SpecPro Inc, USA, Army Engn Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, 201 E Jones St, Lewisville, TX 75057 USA. EM leeann@laerf.org NR 12 TC 6 Z9 7 U1 1 U2 3 PU AQUATIC PLANT MANAGEMENT SOC, INC PI LEHIGH ACRES PA PO BOX 1477, LEHIGH ACRES, FL 33970 USA SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 2007 VL 45 BP 136 EP 138 PG 3 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA 225SD UT WOS:000250536800014 ER PT J AU Duerkop, BA Ulrich, RL Greenberg, EP AF Duerkop, Breck A. Ulrich, Ricky L. Greenberg, E. Peter TI Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing SO JOURNAL OF BACTERIOLOGY LA English DT Article ID LUXR-LUXI FAMILY; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; SYSTEM; PSEUDOMALLEI; AUTOINDUCER; EXPRESSION; GENES; IDENTIFICATION; PROMOTER AB Acyl-homoserine lactones (HSLs) serve as quorum-sensing signals for many Proteobacteria. Members of the LuxI family of signal generators catalyze the production of acyl-HSLs, which bind to a cognate receptor in the LuxR family of transcription factors. The obligate animal pathogen Burkholderia mallei produces several acyl-HSLs, and the B. mallei genome has four lurR and two luxI homologs, each of which has been established as a virulence factor. To begin to delineate the relevant acyl-HSL signals for B. mallei LuxR homologs, we analyzed the BmaR1-BmaI1 system. A comparison of acyl-HSL profiles from B. mallei ATCC 23344 and a B. mallei bmaI1 mutant indicates that octanoyl-HSL synthesis is BmaI1 dependent. Furthermore, octanoyl-HSL is the predominant acyl-HSL produced by BmaI1 in recombinant Escherichia coli. The synthesis of soluble BmaR1 in recombinant E. coli requires octanoyl-HSL or decanoyl-HSL. Insoluble aggregates of BmaR1 are produced in the presence of other acyl-HSLs and in the absence of acyl-HSLs. The bmaI1 promoter is activated by BmaR1 and octanoyl-HSL, and a 20-bp inverted repeat in the bmaI1 promoter is required for bmaI1 activation. Purified BmaR1 binds to this promoter region. These findings implicate octanoyl-HSL as the signal for Bmalk1-BmaI1 quorum sensing and show that octanoyl-HSL and BmaR1 activate bmaT1 transcription. C1 Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA. USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21704 USA. RP Greenberg, EP (reprint author), Univ Washington, Sch Med, Dept Microbiol, 1959 NE Pacific St,Box 357242, Seattle, WA 98195 USA. EM epgreen@u.washington.edu FU NIAID NIH HHS [U54AI057141, U54 AI057141]; NIGMS NIH HHS [T32 GM007270, T32 GM07270] NR 45 TC 26 Z9 26 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD JUL PY 2007 VL 189 IS 14 BP 5034 EP 5040 DI 10.1128/JB.00317-07 PG 7 WC Microbiology SC Microbiology GA 189WQ UT WOS:000248019700007 PM 17496085 ER PT J AU Wolf, SE AF Wolf, Steven E. TI Nutrition and metabolism in burns: State of the Science, 2007 SO JOURNAL OF BURN CARE & RESEARCH LA English DT Article; Proceedings Paper CT State of the Science Burn Research Conference CY OCT 26-29, 2006 CL Washington, DC ID ENTERAL NUTRITION; LEAN MASS; OXANDROLONE; TRIAL; HYPERMETABOLISM; REQUIREMENTS; CATABOLISM; CHILDREN; BALANCE; INJURY C1 USA, Inst Surg Res, San Antonio, TX 78234 USA. Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX USA. RP Wolf, SE (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave,Suite 3611, San Antonio, TX 78234 USA. OI Wolf, Steven/0000-0003-2972-3440 NR 22 TC 5 Z9 7 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1559-047X J9 J BURN CARE RES JI J. Burn Care Res. PD JUL-AUG PY 2007 VL 28 IS 4 BP 572 EP 576 DI 10.1097/BCR.0B013E318093DF2E PG 5 WC Emergency Medicine; Dermatology; Surgery SC Emergency Medicine; Dermatology; Surgery GA 188UH UT WOS:000247944300008 PM 17665517 ER PT J AU Massung, RF Levin, ML Munderloh, UG Silverman, DJ Lynch, MJ Gaywee, JK Kurtti, TJ AF Massung, Robert F. Levin, Michael L. Munderloh, Ulrike G. Silverman, David J. Lynch, Meghan J. Gaywee, Jariyanart K. Kurtti, Timothy J. TI Isolation and propagation of the Ap-Variant 1 strain of Anaplasma phagocytophilum in a tick cell line SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HUMAN GRANULOCYTIC EHRLICHIOSIS; WHITE-TAILED DEER; BORRELIA-BURGDORFERI; IXODES-SCAPULARIS; SALIVARY-GLANDS; BABESIA-MICROTI; AGENT; INFECTION; CULTURE; RICKETTSIAE AB The first tissue culture isolates of the unique Anaplasma phagocytophilum strain, Ap-Variant 1, were obtained in the Ixodes scapularis tick-derived cell line ISE6. Two isolates were from goat blood samples: one from a goat infected with L scapularis ticks from Rhode Island and a second from a goat infected by serial passage of blood from the first infected goat. Eight isolates were made directly from L scapularis ticks collected from white-tailed deer in Minnesota and represent the first isolations of an Anaplasma species directly from ticks. Each of the 10 isolates had a 16S rRNA gene sequence identical to that previously described for Ap-Variant 1, but differences within the ank gene were found that suggest natural variation. Prevalence of Anaplasma in the Minnesota ticks was 63.9%; 23 of 36 ticks tested by PCR were positive. Six of the tick-derived isolates were obtained from a set of 18 PCR-positive ticks, for a 33.3% isolation success rate. The conservation of host tropism among the Rhode Island and Minnesota isolates of Ap-Variant I was examined by use of experimental infections of mice and a goat. A Minnesota tick-derived isolate (MN-61-2) was used to inoculate naive animals, and this isolate was able to infect a goat but unable to infect each of five mice, confirming that the Minnesota isolates have the same host tropism as Ap-Variant I from the northeastern United States. Light and electron microscopy of the Ap-Variant 1 isolate MN-61-2 in ISE6 cells showed cytoplasmic inclusions characteristic of A. phagocytophilum with pleomorphic bacteria in membrane-bound vacuoles and both electron-dense and electron-lucent forms. C1 Ctr Dis Control & Prevent, Viral & Rickettsial Zoonoses Branch, Atlanta, GA 30333 USA. Univ Minnesota, Dept Entomol, St Paul, MN 55108 USA. Univ Maryland Baltimore, Sch Med, Baltimore, MD 21201 USA. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. RP Massung, RF (reprint author), Ctr Dis Control & Prevent, Viral & Rickettsial Zoonoses Branch, 1600 Clifton Rd,MS G-13, Atlanta, GA 30333 USA. EM rfm2@cdc.gov FU NIAID NIH HHS [5R01-AI042792, R01 AI042792] NR 37 TC 27 Z9 27 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 2007 VL 45 IS 7 BP 2138 EP 2143 DI 10.1128/JCM.00478-07 PG 6 WC Microbiology SC Microbiology GA 190QB UT WOS:000248072900007 PM 17475757 ER PT J AU Karkkainen, RL Sankar, BV Tzeng, JT AF Karkkainen, Ryan L. Sankar, Bhavani V. Tzeng, Jerome T. TI A direct micromechanical approach toward the development of quadratic stress gradient failure criteria for textile composites SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article DE textile composites; strength; finite element analysis ID PLAIN-WEAVE COMPOSITES; COMPRESSIVE RESPONSE; MODEL AB Based upon previous results of direct micromechanical method (DMM) analysis of the representative volume element (RVE) of a plain-weave textile composite, two methods for predicting failure envelopes are presented: a parametric ellipse-fitting scheme, and a 27-term quadratic stress-gradient failure criterion. Both include the consideration of micro level stress gradients and effectively predict failure in agreement with the DMM. The parametric ellipse-fitting method was found to agree with DMM results to within a few percent. The quadratic failure criterion was found to agree within 9.3%, but the method is more robust in its ability to predict failure for complex loading cases. C1 Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA. USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Sankar, BV (reprint author), Univ Florida, Dept Mech & Aerosp Engn, POB 116250, Gainesville, FL 32611 USA. EM rkarkkai@ufl.edu; sankar@ufl.edu OI Sankar, Bhavani/0000-0002-4556-1982 NR 19 TC 13 Z9 13 U1 0 U2 2 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0021-9983 EI 1530-793X J9 J COMPOS MATER JI J. Compos Mater. PD JUL PY 2007 VL 41 IS 16 BP 1917 EP 1937 DI 10.1177/0021998307069905 PG 21 WC Materials Science, Composites SC Materials Science GA 202ER UT WOS:000248885300001 ER PT J AU Orloff, G Hale, LTCR AF Orloff, George Hale, L. T. C. Robert TI Mandibular osteotomies in orthognathic surgery SO JOURNAL OF CRANIOFACIAL SURGERY LA English DT Article DE bilateral sagittal split osteotomy; mandibular advancement; mandibular setback; orthognathic surgery ID SAGITTAL SPLIT OSTEOTOMY; INFERIOR ALVEOLAR NERVE; CRANIOFACIAL DISTRACTION OSTEOGENESIS; TEMPOROMANDIBULAR-JOINT DYSFUNCTION; RAMUS OSTEOTOMY; RIGID FIXATION; LINGUAL NERVE; FOLLOW-UP; NEUROSENSORY DEFICIT; CONDYLAR RESORPTION AB Bilateral sagittal split osteotomy is the most commonly used osteotomy of the mandible in orthognathic surgery. The authors describe their experience in evaluating the orthognathic patient with a mandibular deformity. The bilateral sagittal split osteotomy surgical technique used by the authors is reviewed along with postoperative management. C1 Prov St Joseph Med Ctr, Burbank, CA 91505 USA. Brooke Army Med Ctr, Oral & Maxillofacial Surg Residency Program, San Antonio, TX USA. RP Orloff, G (reprint author), Prov St Joseph Med Ctr, 2701 W Alameda Ave,Suite 401, Burbank, CA 91505 USA. EM drorloff@sbcglobal.net NR 91 TC 3 Z9 3 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1049-2275 J9 J CRANIOFAC SURG JI J. Craniofac. Surg. PD JUL PY 2007 VL 18 IS 4 BP 931 EP 938 DI 10.1097/scs.0b013e3180a772cf PG 8 WC Surgery SC Surgery GA 196WI UT WOS:000248513100038 PM 17667689 ER PT J AU Furstenberg, R White, JO AF Furstenberg, Robert White, Jeffrey O. TI Photoluminescence study of the 1.3-1.55 eV defect band in CdTe SO JOURNAL OF CRYSTAL GROWTH LA English DT Article DE characterization; defects; photoluminescence; substrates; cadmium compounds; semiconducting II-VI materials ID HIGH-PURITY CDTE; IDENTIFICATION; LUMINESCENCE; BULK AB We report on the photoluminescence (PL) study of defect levels in bulk CdTe. The PL of CdTe was measured in the 1.3-1.55 eV spectral range and at temperatures from 9 to 300 K. The PL spectra were analyzed numerically and various parameters (peak positions, Huang-Rhys factors, etc.) determined. Numerical modeling of low-temperature spectra was performed, and it was shown that the defect band consists of three distinct transitions. Also, we performed hyper-spectral imaging of PL, at 77 K and analyzed the spatial distribution of defects and calculated the level of spatial correlation between the defects. (C) 2007 Elsevier B.V. All rights reserved. C1 Univ Illinois, Dept Phys, Urbana, IL 61801 USA. Army Res Lab, Adelphi, MD 20783 USA. Univ Illinois, Frederick Seitz Mat Res Lab, Urbana, IL 61801 USA. RP Furstenberg, R (reprint author), USN, Res Lab, 4555 Overlook Ave,SW, Washington, DC 20375 USA. EM robert.furstenberg@gmail.com NR 15 TC 2 Z9 2 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD JUL 1 PY 2007 VL 305 IS 1 BP 228 EP 236 DI 10.1016/j.jcrysgro.2007.03.048 PG 9 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA 187IP UT WOS:000247841300040 ER PT J AU Wong, DC Nguyen, LH Gaunaurd, GC AF Wong, David C. Nguyen, Lam H. Gaunaurd, Guillermo C. TI Time-frequency analysis for radar classification of land-mine images SO JOURNAL OF ELECTRONIC IMAGING LA English DT Article ID BAND; SCATTERING; TARGETS AB We use time-frequency (t-f) analysis techniques to examine the echo returns present in synthetic aperture radar (SAR) images of land-mine fields. A flying platform illuminates a mine field containing various types of mines and "confusers," with an ultra-wideband radar. A number of familiar time-frequency distributions are used to inspect the various possible mine locations above and below the ground surface. The 2-dimensional plots generated by these distributions offer a larger variety of features and clues that facilitate the discrimination of each mine type from the others and from possible "confusers." Conclusions emerge that confirm that the pseudo-Wigner-Ville and the Choi-Williams distributions provide the best discrimination results, as was pointed out in earlier work. Larger mines such as the ones denoted here as "type 1" are the easiest to discriminate. Comparison of mines to clutter objects ("confusers') shows that such objects are clearly distinguishable from all the present metal mines. (c) 2007 SPIE and IS&T. C1 Army Res Lab, Adelphi, MD 20783 USA. RP Wong, DC (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 19 TC 1 Z9 2 U1 0 U2 1 PU I S & T - SOC IMAGING SCIENCE TECHNOLOGY PI SPRINGFIELD PA 7003 KILWORTH LANE, SPRINGFIELD, VA 22151 USA SN 1017-9909 J9 J ELECTRON IMAGING JI J. Electron. Imaging PD JUL-SEP PY 2007 VL 16 IS 3 AR 033014 DI 10.1117/1.2776354 PG 12 WC Engineering, Electrical & Electronic; Optics; Imaging Science & Photographic Technology SC Engineering; Optics; Imaging Science & Photographic Technology GA 228SG UT WOS:000250752100015 ER PT J AU Kobayashi, T Simon, DL AF Kobayashi, Takahisa Simon, Donald L. TI Hybrid Kalman filter approach for aircraft engine in-flight diagnostics: Sensor fault detection case SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 51st ASME Turbo Expo 2006 CY MAY 06-11, 2006 CL Barcelona, SPAIN SP ASME, Int Gas Turbine Inst DE in-flight fault detection; on-board engine model; Kalman filter; flight safety ID NEURAL-NETWORK; JET ENGINES AB In this paper, a diagnostic system based on a uniquely structured Kalman filter is developed for its application to in-flightfault detection of aircraft engine sensors. The Kalman filter is a hybrid of a nonlinear on-board engine model (OBEM) and piecewise linear models. The utilization of the nonlinear OBEM allows the reference health baseline of the diagnostic system to be updated, through a relatively simple process, to the health condition of degraded engines. Through this health baseline update, the diagnostic effectiveness of the in-flight sensor fault detection system is maintained as the health of the engine degrades over time. The performance of the sensor-fault detection system is evaluated in a simulation environment at several operating conditions during the cruise phase of flight. C1 ASRC Aerosp Corp, Cleveland, OH 44135 USA. Glenn Res Ctr, USA, Res Lab, Cleveland, OH 44135 USA. RP Kobayashi, T (reprint author), ASRC Aerosp Corp, 21000 Brookpk Rd, Cleveland, OH 44135 USA. NR 14 TC 18 Z9 18 U1 3 U2 7 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUL PY 2007 VL 129 IS 3 BP 746 EP 754 DI 10.1115/1.2718572 PG 9 WC Engineering, Mechanical SC Engineering GA 194QJ UT WOS:000248358600015 ER PT J AU Tursol, JA Lawrence, C Litt, JS AF Tursol, James A. Lawrence, Charles Litt, Jonathan S. TI Reduced-order Modeling and wavelet analysis of turbofan engine structural response due to foreign object damage (FOD) events SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article AB The development of a wavelet-based feature extraction technique specifically targeting FOD-event induced vibration signal changes in gas turbine engines is described. The technique performs wavelet analysis of accelerometer signals from specified locations on the engine and is shown to be robust in the presence of significant process and sensor noise. It is envisioned that the technique will be combined with Kalman filter thermall health parameter estimation for FOD-event detection via information fusion from these (and perhaps other) sources. Due to the lack of high-frequency FOD-event test data in the open literature, a reduced-order turbo/an structural model (ROM) was synthesized from a finite-element model modal analysis to support the investigation. In addition to providing test data for algorithm development, the ROM is used to determine the optimal sensor location for FOD-event detection. In the presence of significant noise, precise location of the FOD event in time was obtained using the developed wavelet-based feature. C1 QSS Grp Inc, Cleveland, OH 44135 USA. NASA, Glenn Res Ctr, Cleveland, OH 44135 USA. USA, Res Lab, Glenn Res Ctr, Cleveland, OH 44135 USA. RP Tursol, JA (reprint author), Northrop Grumman Ship Syst, Adv Capabil Grp, 6608 Sunscope Dr, Ocean Springs, MS 39564 USA. NR 25 TC 1 Z9 2 U1 1 U2 7 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUL PY 2007 VL 129 IS 3 BP 814 EP 826 DI 10.1115/1.2718230 PG 13 WC Engineering, Mechanical SC Engineering GA 194QJ UT WOS:000248358600024 ER PT J AU Ray, LE Lever, JH Streeter, AD Price, AD AF Ray, Laura E. Lever, James H. Streeter, Alexander D. Price, Alexander D. TI Design and power management of a solar-powered "Cool Robot" for polar instrument networks SO JOURNAL OF FIELD ROBOTICS LA English DT Article AB The Cool Robot is a four-wheel-drive, solar-powered, autonomous robot designed to support summertime science campaigns in Antarctica and Greenland over distances exceeding 500 km. This paper provides an overview of key features of the robot, including design for good mobility, high efficiency, and long-term deployment under solar power in harsh polar environments. The Cool Robot's solar panel box, comprising panels on four sides and a top panel, encounters insolation variations with a bandwidth of up to 1 Hz due to sastrugi. The paper details a unique photovoltaic control algorithm to accommodate these variations. We deployed the robot at Summit Camp, Greenland to validate its mobility and power budget and to assess the photovoltaic control system. The 61 kg robot drove continuously at 0.78 m/s on soft snow, its 160 W average power demand met by solar power alone under clear skies above 16 degrees sun elevation. The power-control system reliably matched input with demand as insolation varied during testing. A simple GPS waypoint-following algorithm provides low-bandwidth path planning and course correction and demonstrated reliable autonomous navigation during testing over periods of 5-8 h. Field data validate the Cool Robot design models and indicate that it will exceed its design goal of carrying a 15 kg payload 500 km across Antarctica in 2 weeks. A brief description of instrument payloads and scientific studies aided by networks of such autonomous solar robots is provided. (c) 2007 Wiley Periodicals, Inc. C1 Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. USA ERDC, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. RP Ray, LE (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. EM lray@dartmouth.edu; james.h.lever@erdc.usace.army.mil; alexander.d.streeter.03@alum.dartmouth.org; alexander.d.price.04@alum.dartmouth.org NR 27 TC 14 Z9 15 U1 0 U2 3 PU WILEY-BLACKWELL PI MALDEN PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA SN 1556-4959 J9 J FIELD ROBOT JI J. Field Robot. PD JUL PY 2007 VL 24 IS 7 BP 581 EP 599 DI 10.1002/rob.20163 PG 19 WC Robotics SC Robotics GA 199OD UT WOS:000248704200003 ER PT J AU Hammond, DL AF Hammond, Derek L. TI Validation of LAB color mode as a nondestructive method to differentiate black ballpoint pen inks SO JOURNAL OF FORENSIC SCIENCES LA English DT Article; Proceedings Paper CT Annual Meeting of the Southeastern-Association-of-Forensic-Document-Examiners CY APR, 2006 CL Atlanta, GA SP SE Assoc Forens Document Examiners DE forensic science; questioned documents; ink examination; writing inks; nondestructive ink differentiation; ballpoint pens; Adobe (R) Photoshop (R) CS; lab color; Video Spectral Comparator-4C AB Nondestructive digital processing methods such as lab color mode (available in Adobe((R)) Photoshop((R))) are emerging as alternative methods for forensic document examiners to use when attempting to differentiate writing instrument inks. Although these techniques appear to be viable, little data currently exists regarding the known or potential error rates associated with these techniques. Without adequate data, the validity and reliability of these techniques, including lab color, can not be established. In an attempt to begin to address these issues, 44 black ballpoint ink pens were obtained and used to create 990 pen-pair samples for analysis using established lab color mode techniques. No erroneous findings of "different" were reported following the examination of the known pen-pair combinations in which the same pen was used to create the samples (n = 44). Of the remaining 946 samples, 737 pen-pair samples were differentiated using the lab color mode method, while 209 samples were unable to be differentiated and were recorded as either being "similar" (n = 153) or "unsure" (n = 56). Comparison of the lab color mode results with the results obtained through additional testing using traditional infrared reflectance and infrared luminescence test methods showed that lab color differentiated 102 pen-pair samples (11%; 102/946) that were not differentiated using a VSC-4C. C1 USA, Criminal Invest Lab, Forens Document Branch, Forest Park, GA 30297 USA. RP Hammond, DL (reprint author), USA, Criminal Invest Lab, Forens Document Branch, 4930 N 31st St, Forest Park, GA 30297 USA. EM derek.hammond@us.army.mil NR 7 TC 2 Z9 2 U1 4 U2 10 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 2007 VL 52 IS 4 BP 967 EP 973 DI 10.1111/j.1556-4029.2007.00469.x PG 7 WC Medicine, Legal SC Legal Medicine GA 178NO UT WOS:000247227600036 PM 17553096 ER PT J AU Kiley, CA Lowry, KJ Mysliwiec, V AF Kiley, Cristin A. Lowry, Kristie J. Mysliwiec, Vincent TI Examination of hospital referral practices for CT pulmonary angiography SO JOURNAL OF HOSPITAL MEDICINE LA English DT Article DE venous thromboembolism; CT pulmonary angiography ID COMPUTED-TOMOGRAPHY; EMERGENCY-DEPARTMENT; D-DIMER; VENOUS THROMBOEMBOLISM; CLINICAL PROBABILITY; EMBOLISM; PREDICTION; VALIDATION; GUIDELINE; DIAGNOSIS AB Guidelines for the evaluation of venous thromboembolism (VTE) include a history and physical examination in conjunction with computed tomographic pulmonary angiography (CTPA), Doppler ultrasonography, and D-dimer measurements. We performed a retrospective analysis to evaluate the diagnostic yield of CTPA at our facility. Patients between the ages of 18 and 100 with a CTPA completed through the emergency department and/or any inpatient service over a 6-month period were reviewed and a retrospective Simplified Wells Score was calculated. Three hundred and three patients underwent CTPA for acute VTE. A Simplified Wells Score was calculated for 279 subjects, with a mean score of 1.6 +/- 1.6. Twenty CTPA procedures demonstrated VTE, a positive rate of 7.2%, which was lower than expected. This result likely reflects lack of adherence to a clinical algorithm for assessment of VTE and an overly cautious approach to symptom evaluation. C1 [Kiley, Cristin A.; Lowry, Kristie J.; Mysliwiec, Vincent] Madigan Army Med Ctr, Tacoma, WA 98431 USA. RP Kiley, CA (reprint author), Walter Reed Army Med Ctr, Dept Internal Med, 6900 Georgia Ave, Washington, DC 20307 USA. EM cristin.kiley@us.army.mil NR 16 TC 4 Z9 4 U1 0 U2 0 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1553-5592 J9 J HOSP MED JI J. Hosp. Med. PD JUL-AUG PY 2007 VL 2 IS 4 BP 253 EP 257 DI 10.1002/jhm.189 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 292HQ UT WOS:000255257500008 PM 17702044 ER PT J AU Muehlenbachs, A Fried, M Lachowitzer, J Mutabingwa, TK Duffy, PE AF Muehlenbachs, Atis Fried, Michal Lachowitzer, Jeff Mutabingwa, Theonest K. Duffy, Patrick E. TI Genome-wide expression analysis of placental malaria reveals features of lymphoid neogenesis during chronic infection SO JOURNAL OF IMMUNOLOGY LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; CIRCULATING IMMUNE-COMPLEXES; ECTOPIC GERMINAL CENTER; CHONDROITIN SULFATE-A; RHEUMATOID-ARTHRITIS; AUTOANTIBODY PRODUCTION; CEREBRAL MALARIA; HOST RESPONSE; TNF-ALPHA; CELLS AB Chronic inflammation during placental malaria (PM) is most frequent in first time mothers and is associated with poor maternal and fetal outcomes. In the first genome-wide analysis of the local human response to sequestered malaria parasites, we identified genes associated with chronic PM and then localized the corresponding proteins and immune cell subsets in placental cryosections. B cell-related genes were among the most highly up-regulated transcripts in inflamed tissue. The B cell chemoattractant CXCL13 was up-regulated > 1,000-fold, and B cell-activating factor was also detected. Both proteins were expressed by intervillous macrophages. Ig L and H chain transcription increased significantly, and heavy depositions of IgG3 and IgM were observed in intervillous spaces. The B cell phenotype was heterogenous, including naive (CD27-negative), mature (CD 138-positive), and cycling (Ki-67-positive) cells. B cells expressed T-bet but not Bcl-6, suggesting T cell-independent activation without germinal center formation. Genes for the Fc binding proteins Fc gamma RIa, Fc gamma RIIIa, and C1q were highly up-regulated, and the proteins localized to intervillous macrophages. Birth weight was inversely correlated with transcript levels of CXCL13, IgG H chain, and IgM H chain. The iron regulatory peptide hepcidin was also expressed but was not associated with maternal anemia. The results suggest that B cells and macrophages contribute to chronic PM in a process resembling lymphoid neogenesis. We propose a model where the production of Ig during chronic malaria may enhance inflammation by attracting and activating macrophages that, in turn, recruit B cells to further produce Ig in the intervillous spaces. C1 Seattle Biomed Res Inst, Mother Offspring Malaria Study Project, Seattle, WA 98109 USA. Univ Washington, Seattle, WA 98195 USA. London Sch Hyg & Trop Med, London WC1, England. Natl Inst Med Res, Dar Es Salaam, Tanzania. Muheza Designated Dist Hosp, Muheza, Tanzania. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Duffy, PE (reprint author), Seattle Biomed Res Inst, Mother Offspring Malaria Study Project, 307 Westlake Ave N Suite 500, Seattle, WA 98109 USA. EM pduffy@sbri.org FU NHLBI NIH HHS [T32 HL 07312, HL 072370]; NIAID NIH HHS [R01 AI 52059] NR 54 TC 37 Z9 39 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUL 1 PY 2007 VL 179 IS 1 BP 557 EP 565 PG 9 WC Immunology SC Immunology GA 182IF UT WOS:000247497600066 PM 17579077 ER PT J AU Kajon, AE Moseley, JM Metzgar, D Huong, HS Wadleigh, A Ryan, MAK Russell, KL AF Kajon, Adriana E. Moseley, Jennifer M. Metzgar, David Huong, Huo-Shu Wadleigh, Aya Ryan, Margaret A. K. Russell, Kevin L. TI Molecular epidemiology of adenovirus type 4 infections in US military recruits in the postvaccination era (1997-2003) SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT 8th International Adenovirum Meeting CY AUG 30-SEP 02, 2006 CL Zurich, SWITZERLAND ID ACUTE RESPIRATORY-DISEASE; GENOME TYPE ANALYSIS; ACUTE CONJUNCTIVITIS; ARMY TRAINEES; YOUNG-ADULTS; SEROTYPES 4; ILLNESS; JAPAN; HEALTHY; SUSCEPTIBILITY AB Background. Military recruits are at a higher risk of respiratory infection than their civilian counterparts. Continuous outbreaks of adenovirus ( Ad)-associated acute respiratory disease were documented among US trainees before the implementation of serotype 4 ( Ad4) and serotype 7 vaccines in 1971. The discontinuation of Ad vaccination programs in 1999 precipitated the reemergence of Ad in training sites, with Ad4 accounting for 98% of all diagnosed cases. Methods. A total of 724 Ad4 strains isolated from recruits presenting with febrile respiratory illness at 8 training sites nationwide between 1997 and 2003 were genome typed by restriction enzyme analysis. Results. Seven genome types were identified, all of which were distinct from the prototype Ad4p and the vaccine type 4p1. Results showed very different, and often stable, genome type distributions at different geographic sites, despite the homogeneity of the recruit source population. Conclusions. The data support the hypothesis that reservoirs for Ad outbreaks are within recruit training sites or in their immediate environments, not in the incoming recruit population. Molecular characterization beyond serotype is critical to understanding the transmission dynamics of Ad infection in these unique susceptible populations and to the implementation of effective prevention approaches. C1 Lovelance Resp Res Inst, Program Infect Dis, Albuquerque, NM 87108 USA. USN, Hlth Res Ctr, Dept Def Ctr Deployment Hlth Res, Resp Dis Lab, San Diego, CA 92152 USA. Walter Reed Army Inst Res, Dept Virus Dis, Silver Spring, MD USA. RP Kajon, AE (reprint author), Lovelance Resp Res Inst, Program Infect Dis, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA. EM akajon@lrri.org RI Valle, Ruben/A-7512-2013; OI Zucca, Aya/0000-0001-8613-8315 NR 50 TC 50 Z9 52 U1 1 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL 1 PY 2007 VL 196 IS 1 BP 67 EP 75 DI 10.1086/518442 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 175BL UT WOS:000246987100012 PM 17538885 ER PT J AU Kim, YG Galand, EM Thompson, BC Walker, J Fossey, SA McCarley, TD Abboud, KA Reynolds, JR AF Kim, Young-Gi Galand, Emilie M. Thompson, Barry C. Walker, John Fossey, Stephen A. McCarley, Tracy D. Abboud, Khalil A. Reynolds, John R. TI Isoregic thienylene-phenylene polymers: The effects of structural variation and application to photovoltaic devices SO JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY LA English DT Article DE PCBM; band gap; solar cells; photovoltaic devices; conjugated polymer; electrochemistry; spectroclectrochemistry ID NARROW-BAND-GAP; STILLE COUPLING REACTION; SOLAR-CELLS; CONJUGATED POLYMERS; ELECTRONIC-PROPERTIES; PROPYLENEDIOXYTHIOPHENE; COPOLYMERS; OXIDATION; OLIGOMERS; HALIDES AB Isoregic conjugated polymers composed of thiophene and dialkoxybenzene units were designed to harvest incident light in the mid-visible energy range (band gap of 2.1 eV). Poly(1,4-bis(2-thienyl)-2,5-diheptoxybenzene) (PBTB(OC7H15)(2)) and poly(1,4-bis(2-thienyl)-2,5-didodecyloxybenzene) (PBTB(OC12H25)(2)) have shown significant photovoltaic performance as an electron donor when used in tandem with the electron acceptor [6, 6]-phenyl C-61-butyric acid methyl ester (PCBM) in bulk hetero-junction photovoltaic devices. Photovoltaic devices incorporating PBTB(OC7H15)(2) and PCBM have shown AM 1.5 efficiencies of similar to 0.6% with a short circuit current density of 2.5 mA/ cm(2), an open circuit voltage of 0.74 V, and a fill factor of 0.32. Incident Photon-to-Current Efficiency (IPCE) of the device was found to be ca. 16% at 410 nm. In order to examine the relationship between the molecular structure of the polymers and their electronic energy levels, and to correlate this with photovoltaic performance, optoelectronic and electrochemical results are discussed in relation to the I-V characteristics of the devices. Additionally, a computer-aided simulation is used to gain further insight into the effect of polymer structure on the energetic relationships in the bulk heterojunction devices. C1 Univ Florida, Ctr Macromol Sci & Engn, Dept Chem, George & Josephine Butler Polymer Res Labs, Gainesville, FL 32611 USA. USA, Natick Soldier Ctr, Soldier & Biol Chem Command, Natick, MA 01760 USA. Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA. RP Reynolds, JR (reprint author), Univ Florida, Ctr Macromol Sci & Engn, Dept Chem, George & Josephine Butler Polymer Res Labs, Gainesville, FL 32611 USA. EM reynolds@chem.ufl.edu NR 40 TC 3 Z9 3 U1 0 U2 2 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA SN 1060-1325 J9 J MACROMOL SCI A JI J. Macromol. Sci. Part A-Pure Appl. Chem. PD JUL-SEP PY 2007 VL 44 IS 7-9 BP 665 EP 674 DI 10.1080/10601320701350906 PG 10 WC Polymer Science SC Polymer Science GA 185QB UT WOS:000247724400002 ER PT J AU Grujicic, M Pandurangan, B Angstadt, DC Koudela, KL Cheeseman, BA AF Grujicic, Mica Pandurangan, B. Angstadt, D. C. Koudela, K. L. Cheeseman, B. A. TI Ballistic-performance optimization of a hybrid carbon-nanotube/E-glass reinforced poly-vinyl-ester-epoxy-matrix composite armor SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID ROPES; FUNCTIONALIZATION; SOLUBILIZATION; FIBERS AB The material model for a multi-walled carbon nanotube (MWCNT) reinforced poly-vinyl-ester-epoxy matrix composite material (carbon nanotube reinforced composite mats, in the following) developed in our recent work (M. Grujicic et al. submitted), has been used in the present work within a transient non-linear dynamics analysis to carry out design optimization of a hybrid polymer-matrix composite armor for the ballistic performance with respect to the impact by a fragment simulating projectile (FSP). The armor is constructed from E-glass continuous-fiber poly-vinyl-ester-epoxy matrix composite laminas interlaced with the carbon nanotube reinforced composite mats. Different designs of the hybrid armor are obtained by varying the location and the thickness of the carbon nanotube reinforced composite mats. The results obtained indicate that at a fixed thickness of the armor, both the position and the thickness of the carbon nanotube reinforced composite mats affect the ballistic performance of the armor. Specifically, it is found that the best performance of the armor is obtained when thicker carbon nanotube reinforced composite mats are placed near the front armor face, the face which is struck by the projectile. The results obtained are rationalized using an analysis of the elastic wave reflection and transmission behavior at the lamina/met and laminate/air interfaces. C1 Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA. Penn State Univ, Appl Res Lab, University Pk, PA 16802 USA. USA, Res Lab, Survivabil Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Grujicic, M (reprint author), Clemson Univ, Dept Mech Engn, 241 Engn Innovat Bldg, Clemson, SC 29634 USA. EM mica.grujicic@ces.clemson.edu NR 30 TC 20 Z9 20 U1 4 U2 23 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUL PY 2007 VL 42 IS 14 BP 5347 EP 5359 DI 10.1007/s10853-006-0959-x PG 13 WC Materials Science, Multidisciplinary SC Materials Science GA 188UA UT WOS:000247943600008 ER PT J AU Foley, DH Rueda, LM Wilkerson, RC AF Foley, Desmond H. Rueda, Leopoldo M. Wilkerson, Richard C. TI Insight into global mosquito biogeography from country species records SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE mosquito; biogeography; country occurrence records; species richness; species-area relationship ID AREA RELATIONSHIPS; PATTERNS; EVOLUTIONARY; DISPERSAL; DIVERSITY; SCALE AB To advance our limited knowledge of global mosquito biogeography, we analyzed country occurrence records from the Systematic Catalog of the Culicidae (http://www.mosquitocatalog. org/main.asp), and we present world maps of species richness and endemism. A latitudinal biodiversity gradient was observed, with species richness increasing toward the equator. A linear log-log species (y)-area (x) relationship (SAR) wits found that we used to compare observed and expected species densities for each country. Brazil, Indonesia, Malaysia, and Thailand had the highest numbers of species, and Brazil also had the highest taxonomic output and number of type locations. Brazil, Australia, the Philippines, and Indonesia had the highest numbers of endemic species, but excluding small island countries, Panama, French Guiana, Malaysia, and Costa Rica had the highest densities of total species and endemic species. Globally, 50% of mosquito species are endemic. Island countries had higher total number of species and higher number of endemic species than mainland countries of similar size, but the slope of the SAR was similar for island and mainland countries. Islands also had higher numbers of publications and type locations, possibly due to greater sampling effort and/or species endemisin on islands. The taxonomic output was lowest for son-ie countries in Africa and the Middle East. A consideration of country estimates of past sampling effort and species richness and endemism is proposed to guide mosquito biodiversity surveys. For species groups, we show that the number of species of Anopheles subgenus Anopheles varies with those of subgenus Cellia in a consistent manner between countries depending on the region. This pattern is discussed in relation to hypotheses about the historical biogeography and ecology of this medically important genus. Spatial analysis of country species records offers new insight into global patterns of mosquito biodiversity and survey history. C1 Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD 20910 USA. RP Foley, DH (reprint author), Walter Reed Army Inst Res, Div Entomol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM foleydes@si.edu RI Valle, Ruben/A-7512-2013; OI Foley, Desmond/0000-0001-7525-4601 NR 31 TC 29 Z9 29 U1 5 U2 13 PU ENTOMOLOGICAL SOCIETY AMERICA PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2007 VL 44 IS 4 BP 554 EP 567 DI 10.1603/0022-2585(2007)44[554:IIGMBF]2.0.CO;2 PG 14 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 185ZH UT WOS:000247748400002 PM 17695008 ER PT J AU Mascari, TM Mitchell, MA Rowton, ED Foil, LD AF Mascari, T. M. Mitchell, M. A. Rowton, E. D. Foil, L. D. TI Evaluation of novaluron as a feed-through insecticide for control of immature sand flies (Diptera : Psychodidae) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE Phlebotomus papatasi; novaluron; sand fly control ID GROWTH-REGULATOR AB The development and survival of sand fly Phlebotomus papatasi Scopoli (Diptera: Psychodidae) larvae fed feces of Syrian hamsters, Mesocricetu, auratus, that had been fed a diet containing novaluron were evaluated. In total, six larval diets were used in sand fly larval bioassays. Four groups of larvae were fed feces of hamsters that had been maintained on a diet containing either 0, 9.88, 98.8, or 988 ppm novaluron. Two additional groups were fed a larval diet composed of equal parts composted rabbit feces and rabbit chow containing either 0 or 988 ppm novaluron. No pupation, hence no adult emergence, occurred when larvae were fed feces of hamsters that were fed diets containing novaluron. The mortality of sand flies fed feces of treated hamsters occurred during larval molts. The results of this study suggest that a control strategy using rodent baits containing novaluron to control phlebotomine sand flies and zoonotic cutaneous leishmaniasis may be possible. C1 Louisiana State Univ, Dept Entomol, Ctr Agr, Agr Expt Stn, Baton Rouge, LA 70803 USA. Louisiana State Univ, Dept Vet Clin Sci, Sch Vet Med, Baton Rouge, LA 70803 USA. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD 20910 USA. RP Mascari, TM (reprint author), Louisiana State Univ, Dept Entomol, Ctr Agr, Agr Expt Stn, 402 Life Sci, Baton Rouge, LA 70803 USA. EM tmascari@agcenter.lsu.edu RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 NR 16 TC 20 Z9 21 U1 0 U2 0 PU ENTOMOLOGICAL SOCIETY AMERICA PI LANHAM PA 10001 DEREKWOOD LANE, STE 100, LANHAM, MD 20706-4876 USA SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 2007 VL 44 IS 4 BP 714 EP 717 DI 10.1603/0022-2585(2007)44[714:EONAAF]2.0.CO;2 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA 185ZH UT WOS:000247748400024 PM 17695030 ER PT J AU Rafuse, ES AF Rafuse, Ethan S. TI Still a mystery? General Grant and the historians, 1981-2006 SO JOURNAL OF MILITARY HISTORY LA English DT Review AB In 1879 General William T. Sherman remarked that, although he had known Ulysses S. Grant for years, "to me he is a mystery, and I believe he is a mystery to himself." Over the last quarter-century many authors have claimed to have solved or at least shed fresh light on the mystery of Grant. For the most part, they have portrayed Grant as a great general and good man, dissenting strongly with the highly negative portrayal of Grant contained in William S. McFeely's 1981 Pulitzer Prize-winning study. This essay traces the evolution of Grant scholarship since 1981 and suggests possible lines of inquiry for future Grant scholars. C1 USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Rafuse, ES (reprint author), USA Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 205 TC 7 Z9 7 U1 0 U2 4 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 EI 1543-7795 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 849 EP 874 DI 10.1353/jmh.2007.0230 PG 26 WC History SC History GA 185AZ UT WOS:000247685000007 ER PT J AU Kiesling, EC AF Kiesling, Eugenia C. TI Illuminating strange defeat and pyrrhic victory: The historian Robert A. Doughty SO JOURNAL OF MILITARY HISTORY LA English DT Article AB "Illuminating Strange Defeat and Pyrrhic Victory: The Historian Robert A. Doughty" is the first of a new genre of Journal of Military History articles designed to explore particular historiographical areas by focusing on the contributions of their most distinguished historians. In surveying the scholarship of Brigadier General (Rtd.) Robert A. Doughty as well as his role in shaping the History Department at the United States Military Academy, this article explores the evolution of English-language interpretations of the fall of France in 1940 and the French effort in the Great War while highlighting Doughty's efforts to teach the U.S. Army how to harness historical study in the interest of doctrinal development. C1 US Mil Acad, West Point, NY 10996 USA. RP Kiesling, EC (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 51 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 875 EP 888 DI 10.1353/jmh.2007.0212 PG 14 WC History SC History GA 185AZ UT WOS:000247685000008 ER PT J AU Rogers, CJ AF Rogers, Clifford J. TI Encyclopedia of the Hundred Years War. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 US Mil Acad, West Point, NY 10996 USA. RP Rogers, CJ (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 913 EP 914 DI 10.1353/jmh.2007.0232 PG 2 WC History SC History GA 185AZ UT WOS:000247685000015 ER PT J AU Weddle, KJ AF Weddle, Kevin J. TI Uriah Levy: Reformer of the Antebellum Navy. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, War Coll, Carlisle, PA 17013 USA. RP Weddle, KJ (reprint author), USA, War Coll, Carlisle, PA 17013 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 925 EP 926 DI 10.1353/jmh.2007.0244 PG 2 WC History SC History GA 185AZ UT WOS:000247685000026 ER PT J AU Raines, RR AF Robbins Raines, Rebecca TI Troubleshooting all the way: A memoir of the 1st Signal Company and combat telephone communications in the 1st infantry division, 1944-1945. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Raines, RR (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 962 EP 963 DI 10.1353/jmh.2007.0231 PG 2 WC History SC History GA 185AZ UT WOS:000247685000053 ER PT J AU Bourque, SA AF Bourque, Stephen A. TI Cobra II: The inside story of the invasion and occupation of Iraq. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. RP Bourque, SA (reprint author), USA, Command & Gen Staff Coll, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 984 EP 985 DI 10.1353/jmh.2007.0175 PG 2 WC History SC History GA 185AZ UT WOS:000247685000069 ER PT J AU Grau, LW AF Grau, Lester W. TI Enduring the freedom: A rogue historian in Afghanistan. SO JOURNAL OF MILITARY HISTORY LA English DT Book Review C1 Foreign Mil Studies Off, Ft Leavenworth, KS USA. RP Grau, LW (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 2007 VL 71 IS 3 BP 986 EP 987 DI 10.1353/jmh.2007.0203 PG 2 WC History SC History GA 185AZ UT WOS:000247685000072 ER PT J AU Cheng, JF Lee, JS Sun, F Jares-Erijman, EA Cross, S Rinehart, KL AF Cheng, Jie-Fei Lee, Jong-Soo Sun, Furong Jares-Erijman, Elizabeth A. Cross, Sue Rinehart, Kenneth L. TI Hamigerols A and B, unprecedented polysulfate sterol dimers from the mediterranean sponge Hamigera hamigera SO JOURNAL OF NATURAL PRODUCTS LA English DT Article ID BIOACTIVE MARINE METABOLITES; INHIBITORY NATURAL-PRODUCTS; PETROSIA-WEINBERGI; TOPSENTIA SP; SULFATES AB Two novel polysulfate sterol dimers, hamigerols A (1) and B (2), have been isolated from the Mediterranean sponge Hamigera hamigera. Their structures and stereochemistry have been assigned from the analysis of spectroscopic data. C1 Univ Illinois, Roger Adams Lab, Urbana, IL 61801 USA. Pharma Mar USA Inc, Cambridge, MA 02139 USA. RP Cheng, JF (reprint author), USA, Tanabe Res Labs, 4540 Towne Ctr Ct, San Diego, CA 92121 USA. EM jcheng@trlusa.com NR 21 TC 6 Z9 6 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0163-3864 J9 J NAT PROD JI J. Nat. Prod. PD JUL PY 2007 VL 70 IS 7 BP 1195 EP 1199 DI 10.1021/np070027x PG 5 WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy GA 194LB UT WOS:000248344800023 PM 17580909 ER PT J AU Robicsek, S Gabrielli, A Wishin, J Woodard, J Layon, J Wang, K Oli, M Hayes, R Robinson, G Tortella, F AF Robicsek, Steven Gabrielli, Andrea Wishin, Judith Woodard, Jennifer Layon, Joe Wang, Kevin Oli, Monika Hayes, Ronald Robinson, Gillian Tortella, Frank TI Bandits: A novel clinical platform to validate the utility of potential brain injury biomarkers SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Univ Florida, Gainesville, FL USA. Walter Reed Army Inst Res, Silver Spring, MD USA. Banyan Biomarkers Inc, Alachua, FL USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P18 BP 1234 EP 1234 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200032 ER PT J AU Wang, KK Kobeissy, FH Zhang, Z Liu, MC Denslow, ND Dave, JR Tortella, FC Hayes, RL AF Wang, Kevin K. Kobeissy, Firas H. Zhang, Zhiqun Liu, Ming Cheng Denslow, Nancy D. Dave, Jitendra R. Tortella, Frank C. Hayes, Ronald L. TI Multidimensional separation-coupled tandem mass spectrometry platform for rapid discovery of putative protein biomarkers for traumatic brain injury SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Univ Florida, Dept Psychiat & Neurosci, Gainesville, FL USA. Walter Reed Army Inst Res, Div Psychiat & Neurosci, Silver Spring, MD USA. Univ Florida, Dept Physiol Sci, Gainesville, FL 32610 USA. RI Dave, Jitendra/A-8940-2011; kobeissy, firas/E-7042-2017 OI kobeissy, firas/0000-0002-5008-6944 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P51 BP 1241 EP 1241 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200061 ER PT J AU Chen, ZY Chan, A Lu, M Marshall, V Sing, G Tortella, F AF Chen, Zhiyong Chan, Allison Lu, May Marshall, Vivienne Sing, George Tortella, Frank TI Treatment with human amnion-derived multipotent progenitor cells as a neuroprotective therapy for traumatic brain injury: Pre-clinical studies SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Stemnion LLC, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P77 BP 1248 EP 1248 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200088 ER PT J AU Williams, A Wei, H Dave, J Tortella, F AF Williams, Anthony Wei, Hans Dave, Jitendra Tortella, Frank TI Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P76 BP 1248 EP 1248 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200086 ER PT J AU Yao, CP Williams, A Lu, M Chen, RW Wei, H Liao, ZL Desouza, K Fleming, A Wang, K Hayes, R Tortella, F Dave, J AF Yao, Changping Williams, Anthony Lu, May Chen, Renwu Wei, Hans Liao, Zhilin Desouza, Katherine Fleming, Angela Wang, Kevin Hayes, Ronald Tortella, Frank Dave, Jit TI Proteomics-based identification of brain, plasma and CSF biomarkers following penetrating ballistic-like brain injury (PBBI) in the rat SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Univ Florida, McKnight Brain Inst, Gainesville, FL USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P80 BP 1249 EP 1249 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200090 ER PT J AU Ottens, A Bustamante, L Golden, E Hayes, R Wang, K Tortella, F Dave, J AF Ottens, Andrew Bustamante, Liliana Golden, Erin Hayes, Ronald Wang, Kevin Tortella, Frank Dave, Jitendra TI Biomarkers of neurotrauma: Comparing the neuroproteome of ischemic and concussive injuries. SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL USA. Univ Florida, McKnight Brain Inst, Dept Neurosci, Gainesville, FL USA. Walter Reed Army Inst Res, Dept Neuropharmacol & Mol Biol, Div Neurosci, Silver Spring, MD USA. RI Ottens, Andrew/K-3352-2012; Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P99 BP 1253 EP 1253 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200109 ER PT J AU Lu, XC Guevarra, P Fleming, A Yang, XF Tortella, F AF Lu, Xi-Chun Guevarra, Paul Fleming, Angela Yang, Xiaofang Tortella, Frank TI Attenuation of ischemic brain injury induced silence brain seizure in rats with delayed treatment of NNZ-2566 SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P100 BP 1254 EP 1254 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200110 ER PT J AU Liu, MC Oli, M Akinyi, L Zheng, WR Kobeissy, F Papa, L Dave, J Tortella, F Hayes, R Wang, K AF Liu, Ming Cheng Oli, Monika Akinyi, Linnet Zheng, Wenrong Kobeissy, Firas Papa, Linda Dave, Jitendra Tortella, Frank Hayes, Ronald Wang, Kevin TI Ubiquitin-C-terminal hydrolase as a biomarker for ischemic and traumatic brain injury SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Univ Florida, Gainesville, FL USA. Banyan Biomarkers Inc, Alachua, FL USA. Orlando Reg Med Ctr Inc, Orlando, FL USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011; kobeissy, firas/E-7042-2017 OI kobeissy, firas/0000-0002-5008-6944 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P160 BP 1268 EP 1268 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200169 ER PT J AU Hartings, J Fabricius, M Strong, A Tortella, F Bhatia, R Bullock, R AF Hartings, Jed Fabricius, Martin Strong, Anthony Tortella, Frank Bhatia, Robin Bullock, Ross TI Cortical spreading depolarizations are associated with high ICP and low map in severe TBI patients SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. Glostrup Cty Hosp, Copenhagen, Denmark. Kings Coll Hosp London, London, England. Virginia Commonwealth Univ, Richmond, VA USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P190 BP 1276 EP 1276 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200200 ER PT J AU Wei, H Williams, A Fleming, A Lim, A De Souza, K Phillips, K Liao, ZL Chen, RW Yao, CP Lu, M Tortella, F Dave, J AF Wei, Hans Williams, Anthony Fleming, Angela Lim, Anna De Souza, Katherine Phillips, Katie Liao, Zhilin Chen, Renwu Yao, Changping Lu, May Tortella, Frank Dave, Jitendra TI Attenuation of pro-inflammatory and apoptotic gene expression with NNZ-2566 following experimental penetrating ballistic-like brain injury (PBBI) SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P189 BP 1276 EP 1276 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200198 ER PT J AU Chen, RW Lu, M Yao, CP Liao, ZL Wei, H Tortella, F Dave, J AF Chen, Renwu Lu, May Yao, Changping Liao, Zhilin Wei, Hans Tortella, Frank Dave, Jitendra TI NNZ-2566 provides neuroprotection against brain injury in rat pbbi by suppressing Bax expression and promoting Bcl-2 level SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RI Yao, Changping/B-3619-2011; Dave, Jitendra/A-8940-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P193 BP 1277 EP 1277 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200202 ER PT J AU Wei, G Yang, XF Tortella, F Lu, M AF Wei, Guo Yang, Xiaofang Tortella, Frank Lu, May TI Selective brain cooling is achieved via an extravascular cooling device for neuroprotection SO JOURNAL OF NEUROTRAUMA LA English DT Meeting Abstract CT 25th Annual National-Neurotrauma-Society Symposium CY JUL 29-AUG 01, 2007 CL Kansas City, MO SP Natl Neurotrauma Soc C1 Walter Reed Army Inst Res, Silver Spring, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0897-7151 J9 J NEUROTRAUM JI J. Neurotrauma PD JUL PY 2007 VL 24 IS 7 MA P210 BP 1281 EP 1281 PG 1 WC Critical Care Medicine; Clinical Neurology; Neurosciences SC General & Internal Medicine; Neurosciences & Neurology GA 186DV UT WOS:000247760200220 ER PT J AU Freiberger, JJ Padilla-Burgos, R Chhoeu, AH Kraft, KH Boneta, O Moon, RE Piantadosi, CA AF Freiberger, John J. Padilla-Burgos, Rebecca Chhoeu, Austin H. Kraft, Kevin H. Boneta, Otto Moon, R. E. Piantadosi, C. A. TI Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: A case series SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID RISK-FACTORS; OSTEOCLASTS AB Purpose: Bisphosphonate (BP)-associated osteonecrosis of the jaw (ONJ) is an emerging problem with few therapeutic options. Our pilot study of BP-ONJ investigated a possible role for hyperbaric oxygen (HBO2) therapy. Patients and Methods: A total of 16 patients, ranging in age from 43 to 78 years, with BP-ONJ were treated with adjunctive HBO2 between July 2003 and April 2006. Staging was based on the size and number of oral lesions. Clinical response after treatment and at distant follow-up; the odds of remission, stabilization, or relapse; and time to failure analysis were calculated. Results: The median time on BP therapy before appearance of ONJ symptoms was 18 months, and that from symptom onset to HBO2 therapy was 12 months. Fourteen of 16 patients (87.5%) improved in stage. The size and number of ONJ lesions were decreased after HBO2 therapy (P <.001 and P =.008, respectively; Wilcoxon signed-rank test). Immediately after HBO2 therapy, 7 of 16 patients (44%) were in remission and 8 (50%) had stabilized; however, stabilization without remission was sustained in only 2 patients. At follow-up, 10 of the patients (62.5%) were still in remission or had stabilized. The 7 patients who continued on BP treatment during HBO2 therapy had a shorter time to failure (8.5 months; 95% confidence interval [CI] = 7.1 to 9.8) than those who discontinued the drug (20.1 months; 95% CI = 17.5 to 23.9; P =.006 by the log-rank test). Clinical response was not associated with cancer type or malignancy remission status. Conclusions: Adjunctive HBO2 therapy may benefit patients with BP-ONJ; however, the outcome is improved with cessation of BP administration. (c) 2007 American Association of Oral and Maxillofacial Surgeons. C1 Duke Univ, Med Ctr, Ctr Hyperbar Med & Environm Physiol, Dept Anesthesiol, Durham, NC 27710 USA. Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA. USAF, Sch Aerosp Med, Hyperbar Med Div, San Antonio, TX USA. RP Freiberger, JJ (reprint author), Duke Univ, Med Ctr, Ctr Hyperbar Med & Environm Physiol, Dept Anesthesiol, Box 3823, Durham, NC 27710 USA. EM freib002@mc.duke.edu NR 21 TC 66 Z9 69 U1 1 U2 2 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUL PY 2007 VL 65 IS 7 BP 1321 EP 1327 DI 10.1016/j.joms.2007.03.019 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 185YD UT WOS:000247745400010 PM 17577496 ER PT J AU Thompson, SH Quinn, M Helman, JI Baur, DA AF Thompson, Stevan H. Quinn, Michael Helman, Joseph I. Baur, Dale A. TI Maxillomandibular distraction osteogenesis advancement for the treatment of obstructive sleep apnea SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article C1 Dept Oral & Maxillofacial Surg, Cleveland, OH 44106 USA. USA, Eisenhower Army Med Ctr, Oral & Maxillofacial Surg Residency Program, Ft Gordon, GA USA. USA, Eisenhower Army Med Ctr, Ft Gordon, GA USA. USA, Sleep Disorder Ctr, Ft Gordon, GA USA. Univ Michigan, Med Ctr, Dept Oral & Maxillofacial Surg, Ann Arbor, MI USA. USA, Eisenhower Army Med Ctr, Oral & Maxillofacial Surg Residency Program, Ft Gordon, GA USA. Case Western Reserve Univ, Univ Hosp, Dept Oral & Maxillofacial Surg, Cleveland, OH 44106 USA. RP Baur, DA (reprint author), Dept Oral & Maxillofacial Surg, 2123 Abington Rd, Cleveland, OH 44106 USA. EM dale.baur@case.edu NR 14 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUL PY 2007 VL 65 IS 7 BP 1427 EP 1429 DI 10.1016/j.jams.2006.05.053 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA 185YD UT WOS:000247745400031 PM 17577517 ER PT J AU Helgeson, MD Potter, BK Evans, KN Shawen, SB AF Helgeson, Melvin D. Potter, Benjamin K. Evans, Korboi N. Shawen, Scott B. TI Bioartificial Dermal Substitute: A Preliminary Report on Its Use for the Management of Complex Combat-Related Soft Tissue Wounds SO JOURNAL OF ORTHOPAEDIC TRAUMA LA English DT Article DE blast injury; dermal substitute; Integra; negative pressure dressing; split-thickness skin graft ID VACUUM-ASSISTED CLOSURE; SECURING SKIN-GRAFTS; ARTIFICIAL SKIN; RECONSTRUCTIVE SURGERY; REGENERATION TEMPLATE; CLINICAL-TRIAL; BURN INJURY; INTEGRA; EXPERIENCE; DRESSINGS AB Objective: To report our institutional experience with the use of a bioartificial dermal substitute (Integra) combined with subatmospheric pressure [vacuum-assisted Closure (VAC)] dressings followed by delayed split-thickness skin grafting for management of complex combat-related soft tissue wounds secondary to blast injuries. Design: Retrospective review of patients treated December 2004 through November 2005. Setting: Military treatment facility. Patients/Participants: Integra grafting was performed 18 times in 16 wounds at our institution. Indications for Integra placement were wounds not amenable to simple split-thickness skin grafting. specifically those with substantial exposed bone and/or tendon. Intervention: Patients underwent an average of 8.5 irrigation and debridement procedures and concurrent VAC dressings prior to placement of the Integra. Following Integra grafting. all patients were managed with VAC dressings, changed every 3 to 4 days at the bedside or in clinic, with subsequent split-thickness skin grafting an average of 19 days later. Main Outcome Measurements: The mechanism and date of injury, size of residual soft tissue deficit, indication for Integra placement, number of irrigation and debridement procedures prior to Integra placement, days from injury to Integra placement, days from Integra placement to split-thickness skin grafting, and clinical outcome were recorded. Results: Integra placement and Subsequent skin grafting was successful in achieving durable and cosmetic definitive coverage in 15 of 16 wounds with two of these patients requiring repeat Integra application. Two patients with difficult VAC dressing placement had early Integra graft failure but successfully healed following repeated Integra application and skin grafting. Conclusions: Bioartificial dermal substitute grafting, when coupled with subatmospheric dressing management and delayed split-thickness skin grafting, is an effective technique for managing complex combat-related soft tissue wounds with exposed tendon. This can potentially lessen the need for local rotational or free flap coverage. C1 [Helgeson, Melvin D.; Potter, Benjamin K.; Evans, Korboi N.; Shawen, Scott B.] Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. RP Shawen, SB (reprint author), Walter Reed Army Med Ctr, Orthopaed Surg Serv, 6900 Georgia Ave NW,Bldg 2,Clin 5A, Washington, DC 20307 USA. EM Scott.Shawen@na.amedd.army.mil NR 35 TC 58 Z9 60 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0890-5339 J9 J ORTHOP TRAUMA JI J. Orthop. Trauma PD JUL PY 2007 VL 21 IS 6 BP 394 EP 399 DI 10.1097/BOT.0b013e318070c028 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA 370SX UT WOS:000260784500007 PM 17620998 ER PT J AU Smith, EL Raney, EM Matzkin, EG Fillman, RR Yandow, SM AF Smith, Eric L. Raney, Ellen M. Matzkin, Elizabeth G. Fillman, Ramona R. Yandow, Suzanne M. TI Trevor's disease: the clinical manifestations and treatment of dysplasia epiphyseal is hemimelica SO JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B LA English DT Article DE dysplasia epiphysealis hemimelica; epiphysis; osteocartilaginous overgrowth; Trevor's disease ID EPIPHYSIALIS HEMIMELICA; MANAGEMENT; ACLASIS; KNEE AB Trevor's disease is a rare abnormality characterized by aberrant osteocartilaginous growth from an epiphysis. We describe six new cases from our institution. A patient with isolated tibial tuberosity involvement is described for the first time. Each patient was classified according to Azouz into localized (three), classical (two) and generalized (one) form. We recommend that parents be counseled regarding the progressive nature of this disorder owing to the chance of worsening deformity with surgical excision alone, and the need to be followed until skeletal maturity. C1 Shriners Hosp Children, Honolulu, HI 96826 USA. Tripler Army Med Ctr, Honolulu, HI USA. Univ Hawaii, John A Burns Sch Med, Honolulu, HI USA. RP Raney, EM (reprint author), Shriners Hosp Children, 1310 Punahou St, Honolulu, HI 96826 USA. EM eraney@shrinenet.org NR 27 TC 16 Z9 19 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1060-152X J9 J PEDIATR ORTHOP B JI J. Pediatr. Orthop.-Part B PD JUL PY 2007 VL 16 IS 4 BP 297 EP 302 PG 6 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA 179NJ UT WOS:000247296300011 PM 17527110 ER PT J AU Millendez, MB Ridout, E Pole, G Edwards, M AF Millendez, Maridelle B. Ridout, Erick Pole, Ginger Edwards, Mary TI Neonatal hyperreninemia and hypertensive heart failure relieved with resection of an intralobar pulmonary sequestration SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE pulmonary sequestration; congestive heart failure; hyperreninemia; neonatal hypertension AB Intralobar pulmonary sequestrations are congenital lung malformations sometimes known to cause symptoms of heart failure in the neonate because of shunting of blood flow from an anomalous systemic feeding artery into the pulmonary venous system. These are cured by pulmonary lobectomy. We report the case of a 37-weeks' gestational age infant who presented with bilateral pleural effusions perinatally, followed by hypertensive heart failure and hyperreninemia 2 weeks postnatally. Computed tomography revealed a large artery from the infradiaphragmatic aorta proximal to the celiac axis supplying a right lower lobe intralobar pulmonary sequestration and 4 small nonstenosed renal arteries. Subsequent to a right lower lobectomy, the patient recovered with a precipitous drop in plasma renin assay level and was discharged from the neonatal intensive care unit in good condition 12 days postoperatively. This is the first reported case of hyperreninemia treated by lobectomy. We hypothesize that the aberrant feeding vessel resulted in a relative deficiency in renal perfusion via a "steal'' effect that was relieved by surgical ligation of the artery. (c) 2007 Elsevier Inc. All rights reserved. C1 Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA. Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA. RP Millendez, MB (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD JUL PY 2007 VL 42 IS 7 BP 1276 EP 1278 DI 10.1016/j.jpedsurg.2007.02.021 PG 3 WC Pediatrics; Surgery SC Pediatrics; Surgery GA 199JT UT WOS:000248692800022 PM 17618895 ER PT J AU Vashishta, P Kalia, RK Nakano, A Homan, BE McNesby, KL AF Vashishta, Priya Kalia, Rajiv K. Nakano, Aiichiro Homan, Barrie E. McNesby, Kevin L. TI Multimillion atom reactive simulations of nanostructured energetic materials SO JOURNAL OF PROPULSION AND POWER LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; ELECTRONIC-STRUCTURE METHODS; PARALLEL COMPUTERS; ALGORITHM; OXIDATION; CERAMICS; SYSTEMS; SPACE; GRIDS AB For large-scale atomistic simulations involving chemical reactions to study nanostructured energetic materials, we have designed linear-scaling molecular dynamics algorithms: 1) first-principles-based fast reactive force field molecular dynamics, and 2) embedded divide-and-conquer density functional theory on adaptive multigrids for quantum-mechanical molecular dynamics. These algorithms have achieved unprecedented scales of quantum-mechanically accurate and well validated, chemically reactive atomistic simulations [0.56 billion-atom first principles-based fast reactive force field molecular dynamics and 1.4 million-atom (0.12 trillion grid points) embedded divide-and-conquer density functional theory, molecular dynamics] in addition to 18.9 billion-atom nonreactive space-time multiresolution molecular dynamics, with parallel efficiency as high as 0.953 on 1920 Itanium2 processors. These algorithms have enabled us to perform reactive molecular dynamics simulations to reveal various atomistic processes during 1) the oxidation of an aluminum nanoparticle, 2) the decomposition and chemisorption of an RDX (1, 3, 5-trinitro-1, 3, 5-triazine) molecule on an aluminum surface, and 3) shock-initiated detonation of energetic nanocomposite material (RDX,crystalline matrix embedded with aluminum nanoparticles. C1 Univ So Calif, Dept Chem Engn & Mat Sci, Los Angeles, CA 90089 USA. Univ So Calif, Dept Mat Sci, Los Angeles, CA 90089 USA. Univ So Calif, Dept Comp Sci, Los Angeles, CA 90089 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Vashishta, P (reprint author), Univ So Calif, Dept Chem Engn & Mat Sci, Los Angeles, CA 90089 USA. NR 34 TC 10 Z9 10 U1 0 U2 4 PU AMER INST AERONAUTICS ASTRONAUTICS PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0748-4658 EI 1533-3876 J9 J PROPUL POWER JI J. Propul. Power PD JUL-AUG PY 2007 VL 23 IS 4 BP 688 EP 692 DI 10.2514/1.25651 PG 5 WC Engineering, Aerospace SC Engineering GA 190QC UT WOS:000248073000007 ER PT J AU Mishchenko, MI Videen, G Babenko, VA Khlebtsov, NG Wriedt, T AF Mishchenko, Michael I. Videen, Gorden Babenko, Victor A. Khlebtsov, Nikolai G. Wriedt, Thomas TI Comprehensive T-matrix reference database: A 2004-06 update SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Electromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst DE electromagnetic scattering; T-matrix method ID AXIALLY-SYMMETRIC PARTICLES; GREENS-FUNCTION FORMALISM; MORPHOLOGY-DEPENDENT RESONANCES; LIGHT-SCATTERING SIMULATION; SIZE-DISTRIBUTION FUNCTION; MICROWAVE LIMB RADIANCES; VECTOR MULTIPOLE FIELDS; GENERALIZED MIE THEORY; ICE-CRYSTAL GEOMETRY; OPTICAL-PROPERTIES AB The T-matrix method is one of the most versatile, efficient, and widely used theoretical techniques for the computation of electromagnetic scattering by single and composite particles, discrete random media, and particles in the vicinity of an interface separating two half-spaces with different refractive indices. This paper presents an update to the comprehensive database of T-matrix publications authored by us previously and includes the publications that appeared since 2004. It also lists several earlier publications not included in the original database. (c) 2007 Elsevier Ltd. All rights reserved. C1 NASA, Goddard Inst Space Studies, New York, NY 10025 USA. USA, Res Lab, AMSRL IS EE, Adelphi, MD 20783 USA. Natl Acad Sci Belarus, Stepanov Inst Phys, Minsk 220072, Byelarus. Russian Acad Sci, Inst Biochem & Physiol Plants & Microorganisms, Saratov 410015, Russia. Inst Werkstofftech, D-28359 Bremen, Germany. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM crmim@giss.nasa.gov RI Mishchenko, Michael/D-4426-2012; Khlebtsov, Nikolai/D-6199-2017; Pylaev, Timofey/A-8401-2016; OI Pylaev, Timofey/0000-0002-2701-3333; Khlebtsov, Nikolai/0000-0002-2055-7784 NR 283 TC 34 Z9 36 U1 0 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 EI 1879-1352 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 304 EP 324 DI 10.1016/j.jqsrt.2007.01.022 PG 21 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300027 ER PT J AU Muinonen, K Zubko, E Tyynela, J Shkuratov, YG Videen, G AF Muinonen, Karri Zubko, Evgenij Tyynela, Jam Shkuratov, Yurij G. Videen, Gorden TI Light scattering by Gaussian random particles with discrete-dipole approximation SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Eledtromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst DE light scattering; non-spherical particles; roughness; discrete-dipole approximation ID RAY OPTICS APPROXIMATION; DUST PARTICLES; BACKSCATTERING; SIZE; RAYLEIGH; SPHERES; GRAINS AB We study scattering of light by Gaussian-random-sphere particles with sizes comparable to or slightly larger than the wavelength of incident light. Using an efficient computer code based on the discrete-dipole approximation, the scattering computations are carried out for a set of particle sizes, refractive indices, and statistical shape parameters. For the present mean-radius (a) size parameters x = ka is an element of[1, 7] (k is the wave number), there are intriguing similarities and differences in scattering by spherical and Gaussian particles. However, we can summarize several ubiquitous results for scattering by Gaussian particles. First, for all cases studied, there is an increase toward backscattering in the scattering-phase-matrix element P-11 (phase function). Its angular width diminishes with increasing particle size. Second, in the degree of linear polarization for unpolarized incident light -P-21/P-11, there is a systematic negative polarization feature that is wider for larger refractive indices and smaller particle sizes. Third, P-22/P-11, equal to unity for spherical particles, shows a double-lobe feature in the backward-scattering regime. Fourth, when plotted two-dimensionally against the scattering angle and size parameter, -P-21/P-11 shows positive islands and bridges at intermediate scattering angles. Physical mechanisms are suggested for the backscattering phenomena reported. (c) 2007 Elsevier Ltd. All rights reserved. C1 Univ Helsinki, FI-00014 Helsinki, Finland. Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. Hokkaido Univ, Inst Low Temp Sci, Sapporo, Hokkaido 0600819, Japan. USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Muinonen, K (reprint author), Univ Helsinki, POB 14, FI-00014 Helsinki, Finland. EM Karri.Muinonen@helsinki.fi RI Tyynela, Jani/H-4761-2011 NR 29 TC 56 Z9 57 U1 2 U2 23 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 360 EP 377 DI 10.1016/j.jqsrt.2007.01.049 PG 18 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300030 ER PT J AU Petrov, D Shkuratov, Y Zubko, E Videen, G AF Petrov, D. Shkuratov, Yu. Zubko, E. Videen, G. TI Sh-matrices method as applied to scattering by particles with layered structure SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Eledtromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst DE scattering; Sh-matrices ID LIGHT-SCATTERING; ELECTROMAGNETIC SCATTERING; NONSPHERICAL PARTICLES; SPHERE AB We develop a modification of the T-matrix method that allows for fast calculations of light-scattering properties of non-spherical particles with layered structure. This modification uses the Sh-matrices that depend on the shape of particles only and do not depend on the particle size or optical constants. The matrices are obtained for any number of discrete layers of a particle with different thickness and refractive indices. This solution is generalized for continuously varying refractive index as a function of distance from the particle center. Solutions are considered for the cases when the refractive index changes linearly as well as with the exponential, normal, and Poisson's laws. (c) 2007 Elsevier Ltd. All rights reserved. C1 Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. Hokkaido Univ, Inst Low Temp Sci, Sapporo, Hokkaido 0600819, Japan. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Petrov, D (reprint author), Kharkov VN Karazin Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM petrov@astron.kharkov.ua NR 14 TC 13 Z9 13 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 437 EP 454 DI 10.1016/j.jqsrt.2007.01.027 PG 18 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300035 ER PT J AU Psarev, V Ovcharenko, A Shkuratov, Y Belskaya, I Videen, G AF Psarev, V. Ovcharenko, A. Shkuratov, Yu. Belskaya, I. Videen, G. TI Photometry of particulate surfaces at extremely small phase angles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Electromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst DE photometry; polarimetry; laboratory samples; small phase angles ID PLANETARY REGOLITHS; POLARIZATION; REFLECTANCE; PARTICLES AB We present results of goniometric photometry of different samples at extremely small phase angles using a new laboratory setup with a laser light source (lambda = 0.63 mu m). No opposition effect of carbon soot is found in the range 0.008-1.5 degrees; whereas, MgO deposits and very disperse porous SiO(2) powder demonstrate a narrow brightness spike of significant amplitude. We find a strong dependence of phase curve slope in the range on albedo when studying mixtures of white chalk and carbon soot. These measurements as applied to interpretation of opposition effect observed for Kuiper belt objects suggest that the albedo of these objects cannot be small. Size particle separates of olivine reveal prominent opposition spikes independent of the particle size. Spherical particles with a diameter near 50 pin show significant differences in their scattering behavior depending on whether they form a monolayer or thick particulate surfaces. The latter show a sharp opposition surge unlike the monolayer. Except for the monolayer of spheres, no particulate surface in our measurements yet exhibits phase curve rounding as the phase angle approaches zero. (c) 2007 Elsevier Ltd. All rights reserved. C1 Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. Natl Acad Sci Ukraine, Main Astron Observ, Kiev, Ukraine. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Psarev, V (reprint author), Kharkov VN Karazin Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM pva@astron.kharkov.ua RI Belskaya, Irina/A-7312-2013 OI Belskaya, Irina/0000-0002-5796-6493 NR 11 TC 14 Z9 14 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 455 EP 463 DI 10.1016/j.jqsrt.2007.01.028 PG 9 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300036 ER PT J AU Shkuratov, Y Bondarenko, S Kaydash, V Videen, G Munoz, O Volten, H AF Shkuratov, Yuriy Bondarenko, Sergey Kaydash, Vadym Videen, Gorden Munoz, Olga Volten, Hester TI Photometry and polarimetry of particulate surfaces and aerosol particles over a wide range of phase angles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Eledtromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst DE polarimetry; light-scattering; photometry; negative polarization; opposition effect; coherent backscatter ID INDEPENDENTLY SCATTERING PARTICLES; BIDIRECTIONAL REFLECTANCE; RADIATIVE-TRANSFER; POLARIZATION; MATRICES AB We present results of photometric and polarimetric laboratory measurements of particulate surfaces undergoing different degrees of compression and aerosol particles at a phase angle range from 7 to 150 degrees. Nine samples of natural materials with different albedo and particle sizes were measured in red (lambda = 0.63 mu m) and blue (lambda = 0.44 mu m) light using two different instruments: Kharkov's large-phase-angle photopolarimeter for measurements of surfaces and Amsterdam's polar nephelometer for particles in air. We compare phase curves for particulate surfaces with the corresponding measurements for single particles. Our measurements suggest that the maximum of positive polarization, which is observed for particulate surfaces at large phase angles, is mainly due to the contribution of single-particle scattering. We observe an increase in the polarization degree at large phase angles with increased sample compression. We have found the negative polarization at small phase angles to be strengthened sharply by surface compression. This is partially a geometric effect at slanting view (70 degrees), which is explained via double scattering. For photometric data, we carried out a comparison between experimental data and the Hapke photometric model. The comparison of measured photometric phase-angle dependencies with the model reveals several model shortcomings. The principle shortcoming is the spectral dependence of the model parameters that should be independent of wavelength. (c) 2007 Elsevier Ltd. All rights reserved. C1 Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. CSIC, Inst Astrofis Andalucia, E-18008 Granada, Spain. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Shkuratov, Y (reprint author), Kharkov Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM shkuratov@vk.kh.ua OI Munoz, Olga/0000-0002-5138-3932 NR 12 TC 38 Z9 38 U1 1 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 487 EP 508 DI 10.1016/j.jqsrt.2007.01.031 PG 22 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300039 ER PT J AU Stankevich, D Istomina, L Shkuratov, Y Videen, G AF Stankevich, Dmitriy Istomina, Larissa Shkuratov, Yuriy Videen, Gorden TI The scattering matrix of random media consisting of large opaque spheres calculated using ray tracing and accounting for coherent backscattering enhancement SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Eledtromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst ID PARTICULATE MEDIA; OPPOSITION; POLARIZATION; LIGHT AB Phase curves of the scattering Mueller matrix elements are calculated for light scattering in media randomly packed with large, non-transparent spheres (X = 125), the surfaces of which reflect light according to the Fresnel equations. We here consider three values of the refractive index: m = 0.73 + 5.93i (metal Al), 1.6 + 1.72i (metal Fe), and 1.5 + 0.1i (black glass). We use a Monte Carlo ray-tracing approach, taking into account the coherent backscattering effects. The ray-tracing procedure is based on calculation of the Jones matrix for each ray originating from a random starting point with a given incident direction. When the ray leaves the medium after n reflections, we try to found the so-called reciprocal ray, which is reflected by the same subset of particles, but in the reverse order. If such a ray exists, we calculate the corresponding Jones matrix and sum this with the Jones matrix of the initial ray coherently. Then the Mueller matrix is calculated. We find that the main contributions to the coherent opposition spike are the second and third orders of reflection. Higher reflection orders make only a minor contribution to the total intensity even for highly reflective materials like Al. For these media we detect weak negative polarization branches at small phase angles. Their depth and width are about 0.5% and 7, respectively. The iron shows a deeper negative polarization branch, and aluminum (bright metal) demonstrates almost zero polarization; whereas, dark glass takes an intermediate position. We find that for the second scattering order, the normalized elements of the scattering matrix, M-22/M-11, M-33/M-11, and M-44/M-11, depend noticeably on density at small phase angles. All elements on the main diagonal of the scattering matrix are sensitive to the angle of incidence; whereas, those on the secondary diagonals are sensitive to the phase angle. Phase dependencies of the elements -M-21/M-11, -M-12/M-11, -M-43/M-11, and -M-34/M-11 for oblique illumination shift relative to the case of normal illumination. In the case of -M-21/M-11 this shift has been observed experimentally. (c) 2007 Elsevier Ltd. All rights reserved. C1 Kharkov VN Karazin Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Stankevich, D (reprint author), Kharkov VN Karazin Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM stankevich@astron.kharkov.ua NR 18 TC 5 Z9 5 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 509 EP 519 DI 10.1016/j.jqsrt.2007.01.030 PG 11 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300040 ER PT J AU Tyynela, J Zubko, E Videen, G Muinonen, K AF Tyynela, Jani Zubko, Evgenij Videen, Gorden Muinonen, Karri TI Interrelating angular scattering characteristics to internal electric fields for wavelength-scale spherical particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Electromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst DE Lorenz-Mie scattering; opposition effect; negative polarization; coherent backscattering; non-spherical particles ID LIGHT-SCATTERING; MATRICES AB The origin of negative polarization observed in the backscattering region of wavelength-scale spherical particles has been attributed to surface waves. We demonstrate that the internal-field components have a more prominent role in producing this phenomenon. The internal field of spherical particles is computed for different size parameters and refractive indices. The effect of the internal field on the scattered field is studied by modifying the field components of the discretized internal field of the particle. The incident field is assumed to be X-polarized and to propagate in the direction of the Z-axis. For the different internal-field cases, we tabulate the asymmetry parameters of the phase functions, and the so-called polarization norms and asymmetry parameters. We show that both the Z- and X-component of the internal field cause negative polarization, the Z-component directly and the X-component through constructive interference between the contributions from different parts of the particle interior. The former component has a more pronounced influence on the overall polarization, which is readily seen in the polarization norm and asymmetry parameter becoming predominantly more positive for all parameters investigated. The latter component dominates the negative linear polarization close to the backscattering direction and is additionally seen to be responsible for the backscattering peak. (c) 2007 Elsevier Ltd. All rights reserved. C1 Univ Helsinki, FI-00014 Helsinki, Finland. Hokkaido Univ, Inst Low Temp Sci, Sapporo, Hokkaido 0600819, Japan. USA, Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA. Univ Amsterdam, Astron Inst Anton Pannekoek, NL-1098 SJ Amsterdam, Netherlands. RP Tyynela, J (reprint author), Univ Helsinki, POB 14, FI-00014 Helsinki, Finland. EM jtyynela@astro.helsinki.fi RI Tyynela, Jani/H-4761-2011 NR 22 TC 25 Z9 25 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 520 EP 534 DI 10.1016/j.jqsrt.2007.01.032 PG 15 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300041 ER PT J AU Zubko, E Muinonen, K Shkuratov, Y Videen, G Nousiainen, T AF Zubko, Evgenij Muinonen, Karri Shkuratov, Yuriy Videen, Gorden Nousiainen, Timo TI Scattering of light by roughened Gaussian random particles SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER LA English DT Article; Proceedings Paper CT 9th International Conference on Eledtromagnetic and Light Scattering by Non-Spherical Particles CY JUN 05-09, 2006 CL Sobolev Astron Inst, St Petersburg, RUSSIA HO Sobolev Astron Inst ID DISCRETE-DIPOLE APPROXIMATION; MAXWELLS EQUATIONS; NUMERICAL-SOLUTION; SURFACE-ROUGHNESS; POLARIZATION AB We study the influence of surface roughness on light scattering by Gaussian-random-rough particles. Altogether, we consider four kinds of roughened surfaces: small-scale or large-scale roughening of the particle surface layers that are either thin or thick. We have performed computations for two realistic values of refractive indices corresponding to water ice (m = 1.313 + Oi) and silicates (m = 1.6 + 0.0005i). We vary the circumscribing-sphere size parameter x(cs) from 2 up to 12 in the case of silicate particles and up to 14 in the case of icy particles. For all sets of parameters, scattering of light by roughened particles is noticeably different from scattering by unroughened Gaussian particles. The parameter most sensitive to roughening is the degree of linear polarization of the scattered light when illuminated by unpolarized incident light. Except for the backscattering regime, roughening of particles increases the degree of polarization. Near backscattering, the dependence is more complicated. In the case of icy particles, roughening typically decreases the amplitude of the negative polarization surge; whereas, in the case of silicate particles, the dependence is non-monotonic: for x(cs) < 10, roughening neutralizes the surge; whereas, for x(cs) = 10 and 12, it makes the surge more pronounced. Particles with large spatial scale roughness produce less negative polarization than those with small-scale roughness. Particles with thin roughened surface layers generally produce larger negative polarization surges than those with thick layers. The intensity of scattered light is sensitive to roughening mostly near the backscattering although, for silicate particles with thick layers of roughened surface, we detect its influence also near forward scattering. In the case of icy particles, for x(cs) = 12 and 14, thick-layer roughness amplifies the intensity of backscattering; whereas, for other cases, roughening results in decreased backscattering. Particles with thick roughened layers produce typically more gentle angular profiles of intensity near backscattering than the unroughened particles or particles with thin roughened layers. (c) 2007 Elsevier Ltd. All rights reserved. C1 Kharkov Natl Univ, Astron Inst, UA-61022 Kharkov, Ukraine. Hokkaido Univ, Inst Low Temp Sci, Kita Ku, Sapporo, Hokkaido 0600819, Japan. Univ Helsinki, FIN-00014 Helsinki, Finland. USA, Res Lab, AMSRD ARL CI EM, Adelphi, MD 20783 USA. Univ Helsinki, Dept Phys Sci, Div Atmospher Sci, FI-00014 Helsinki, Finland. RP Zubko, E (reprint author), Kharkov Natl Univ, Astron Inst, 35 Sumskaya St, UA-61022 Kharkov, Ukraine. EM zubko@lowtem.hokudai.ac.jp RI Nousiainen, Timo/A-7982-2008 OI Nousiainen, Timo/0000-0002-6569-9815 NR 18 TC 41 Z9 41 U1 0 U2 16 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4073 J9 J QUANT SPECTROSC RA JI J. Quant. Spectrosc. Radiat. Transf. PD JUL-AUG PY 2007 VL 106 IS 1-3 BP 604 EP 615 DI 10.1016/j.jqsrt.2007.01.050 PG 12 WC Optics; Spectroscopy SC Optics; Spectroscopy GA 182NC UT WOS:000247510300047 ER PT J AU Freedman, BA Javernick, MA O'Brien, FP Ross, AE Doukas, WC AF Freedman, Brett A. Javernick, Matthew A. O'Brien, Frederick P. Ross, Amy E. Doukas, William C. TI Arthroscopic versus open distal clavicle excision: Comparative results at six months and one year from a randomized, prospective clinical trial SO JOURNAL OF SHOULDER AND ELBOW SURGERY LA English DT Article ID ACROMIOCLAVICULAR JOINT; SHOULDER PAIN; RESECTION; QUESTIONNAIRES AB The purpose of this report is to compare outcomes of after arthroscopic versus open distal clavicle excision in the treatment of refractory acromioclavicular joint pain. A randomized, prospective clinical trial comparing the 6-month and 1-year outcomes of patients undergoing open distal clavicle excision (group 1) with those undergoing arthroscopic distal clavicle excision (group 2) was carried out. The Modified American Shoulder and Elbow Surgeons form, visual analog scale pain score, Short Form 36, and satisfaction questions were assessed preoperatively and at 6 months and I year postoperatively. Seventeen patients were enrolled. There was a trend across all measures for earlier or better outcomes (or both) after arthroscopic over open treatment. The improvement in visual analog scale pain score from preoperatively to I year postoperatively was significant for group 2 but not group 1 (P = .006 vs P = .13). Occult intra-articular pathology was detected and treated in 50% of group 2 patients. Arthroscopic and open distal clavicle excisions both provide significant pain reduction at I year. Both are effective surgeries for the treatment of refractory acromioclavicular joint pain. The ability to diagnosis and treat subtle concomitant shoulder pathology is a unique advantage of the orthroscopic approach. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA. RP Freedman, BA (reprint author), 4930 Battery Ln,Apartment 3, Bethesda, MD 20814 USA. EM brettfreedman@yahoo.com NR 24 TC 16 Z9 17 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 1058-2746 J9 J SHOULDER ELB SURG JI J. Shoulder Elbow Surg. PD JUL-AUG PY 2007 VL 16 IS 4 BP 413 EP 418 DI 10.1016/j.jse.2006.10.006 PG 6 WC Orthopedics; Sport Sciences; Surgery SC Orthopedics; Sport Sciences; Surgery GA 198WG UT WOS:000248657600006 PM 17448696 ER PT J AU Stojanovic, MP Cheng, J Larkin, TM Cohen, SP AF Stojanovic, Milan P. Cheng, Jianguo Larkin, Thomas M. Cohen, Steven P. TI Psychophysical measurements during lumbar discography - A heart rate response study SO JOURNAL OF SPINAL DISORDERS & TECHNIQUES LA English DT Article DE discography; low back pain; heart rate ID LOW-BACK-PAIN; DISC DISRUPTION; SPINE AB Study Design: Prospective clinical data analysis Objective: To determine if heart rate (HR) response correlates with positive discography results. Summary of Background Data: Lumbar discography is a controversial tool for the diagnosis of discogenic low back pain. The subjective nature of discography can make data interpretation difficult, leading to false-positive and false-negative results. HR changes have been found in numerous studies to be a reliable and valid indicator of acute pain. To date, there is no study analyzing the FIR response to discography-induced pain. Methods: The HR measurements were recorded immediately preceding and after contrast injection into the each disc, and statistically correlated with the provocation of concordant pain, nonconcordant pain, and nonpainful discs. Results: Discography was performed in 26 subjects with low back pain. Among 75 discograms, 26 discs elicited concordant pain, 9 provoked nonconcordant pain, and 40 elicited no pain response. There was no significant change in HR during disc stimulation for negative [no pain response (P = 0.19) and nonconcordant (P = 0.26)] discograms, whereas positive discograms [concordant pain (numerical rating scale >= 6/10)] were associated with a statistically significant increase in FIR (P = 0.000002). Conclusions: Lumbar discography induces positive HR response only in positive discograms. Although there is no immediate practical application of these results, 2 implications may deserve future research: (a) correlation of HR response with surgical and intradiscal electrotherapy treatment outcomes; (b) evaluation of HR measurement in cases of false-positive results (concordant pain on discography but no FIR response). C1 Massachusetts Gen Hosp, MGH Pain Ctr, Intervent Pain Program, Dept Anesthesia & Crit Care, Boston, MA 02114 USA. Harvard Univ, Sch Med, Boston, MA USA. Uniformed Serv Univ Hlth Sci, Walter Reed Army Med Ctr, Washington, DC USA. Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA. RP Stojanovic, MP (reprint author), Massachusetts Gen Hosp, MGH Pain Ctr, Intervent Pain Program, Dept Anesthesia & Crit Care, ACC-333,Fruit St, Boston, MA 02114 USA. EM mstojanovic@partners.org NR 19 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1536-0652 J9 J SPINAL DISORD TECH JI J. Spinal Disord. Tech. PD JUL PY 2007 VL 20 IS 5 BP 387 EP 391 DI 10.1097/BSD.0b013e31802db145 PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 188BR UT WOS:000247894000010 PM 17607105 ER PT J AU Wu, C Ayers, PD Anderson, AB AF Wu, C. Ayers, P. D. Anderson, A. B. TI Validating a GIS-based multi-criteria method for potential road identification SO JOURNAL OF TERRAMECHANICS LA English DT Article DE vehicle tracking; movement pattern; training area impact; GPS; GIS ID TRAINING EXERCISES; VEHICLE; PATTERNS; IMPACTS AB This paper investigated the validation of a multi-criteria method for identifying potential roads, and demonstrated the capability of analyzing GPS vehicle tracking data for identifying vehicle movement patterns and potential roads. The multi-criteria method was evaluated by comparing the predictions to the site visit results on 34 selected road segments meeting different criteria levels. Results show that locations meeting higher criteria levels have higher possibilities to be roads: an approximately 91% possibility of road existence for the locations meeting all five criteria; 55% for the locations meeting four criteria; and 14% for those meeting criteria level two or three. This approach provides an opportunity for land managers to update existing GIS roads map, or identify newly formed roads that may need either rehabilitation or inclusion into the roads maintenance program. (c) 2007 ISTVS. Published by Elsevier Ltd. All rights reserved. C1 Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN 37996 USA. USA, ERDC, CERL, Champaign, IL 61822 USA. RP Ayers, PD (reprint author), Univ Tennessee, Dept Biosyst Engn & Soil Sci, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM ayers@utk.edu NR 19 TC 3 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD JUL PY 2007 VL 44 IS 3 BP 255 EP 263 DI 10.1016/j.jterra.2007.04.001 PG 9 WC Engineering, Environmental SC Engineering GA 220KO UT WOS:000250155800004 ER PT J AU McKennaa, MH Stump, BW Hayek, S McKenna, JR Stanton, TR AF McKennaa, Mihan H. Stump, Brian W. Hayek, Sylvia McKenna, Jason R. Stanton, Terry R. TI Tele-infrasonic studies of hard-rock mining explosions SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article AB The Lac-du-Bonnet infrasound station, IS-10, and the Minnesota iron mines 390 km to the southeast are ideally located to assess the accuracy of atmospheric profiles needed for infrasound modeling. Infrasonic data from 2003 associated with explosions at the iron mine were analyzed for effects of explosion size and atmospheric conditions on observations with well-constrained ground truth. Noise was the determining factor for observation; high noise conditions sometimes prevented unequivocal identification of infrasound arrivals. Observed arrivals had frequencies of 0.5 to 5 Hz, with a dominant frequency of 2 Hz, and generally had durations on the order of 10 s or less. There was no correlation between explosive amount and observability. Tele-infrasonic propagation distances (greater than 250 km) produce thermospheric ray paths. Modeling is based upon MSIS/HWM (Mass Spectrometer Incoherent Scatter/Horizontal Wind Model) and NRL-G2S (Naval Research Laboratory Ground to Space) datasets. The NRL-G2S dataset provided more accurate travel time predictions that the MSIS/HWM dataset. PE modeling for the NRL-G2S dataset indicates energy loss at higher frequencies (around 4 Hz). Additionally, applying the Sutherland/Bass model through the NRL-G2S realization of the atmosphere in InfraMAP results in predicted amplitudes too small to be observed. (c) 2007 Acoustical Society of America. C1 USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Struct Engn Branch, Vicksburg, MS 39180 USA. So Methodist Univ, Dept Geol Sci, Dallas, TX 75275 USA. Nat Resources Canada, Ottawa, ON K1A 0Y3, Canada. USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Engn Geol & Geophys Branch, Vicksburg, MS 39180 USA. RP McKennaa, MH (reprint author), USA, Engineer Res & Dev Ctr, Geotech & Struct Lab, Struct Engn Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Mihan.H.McKenna@erdc.usace.army.mil; Bstump@smu.edu; Sylvia.Hayek@nrcan-rncan.gc.ca; Jason.R.McKenna@erdc.usace.army.mil; Terry.R.Stanton@erdc.usace.army.mil NR 25 TC 13 Z9 13 U1 1 U2 3 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2007 VL 122 IS 1 BP 97 EP 106 DI 10.1121/1.2741375 PG 10 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 191WA UT WOS:000248161500008 PM 17614468 ER PT J AU Ostashev, VE Collier, SL Wilson, DK Aldridge, DF Symons, NP Marlin, D AF Ostashev, Vladimir E. Collier, Sandra L. Wilson, D. Keith Aldridge, David F. Symons, Neill P. Marlin, David TI Pade approximation in time-domain boundary conditions of porous surfaces SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND-PROPAGATION; FINITE-DIFFERENCE; MEDIA; IMPEDANCE; WAVE; IMPLEMENTATION; SIMULATION; MODELS AB Formulation and implementation of time-domain boundary conditions (TDBCs) at the surface of a reactive porous material are made challenging by the slow decay, complexity, or noncausal nature of many commonly used models of porous materials. In this paper, approaches are described that improve computational efficiency and enforce causality. One approach involves approximating the known TDBC for the modified Zwikker-Kosten impedance model as a summation of decaying exponential functions. A second approach, which can be applied to any impedance model, involves replacing the characteristic admittance with its Pade approximation. Then, approximating fractional derivatives with decaying exponentials, a causal and recursive TDBC is formulated (c) 2007 Acoustical Society of America. C1 NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. New Mexico State Univ, Dept Phys, Las Cruces, NM 88003 USA. USA Res Lab, Adelphi, MD 20783 USA. USA, Engineer Res & Dev Ctr, Hanover, NH 03755 USA. Sandia Natl Labs, Dept Geophys, Albuquerque, NM 87185 USA. USA Res Lab, White Sands Missile Range, NM 88002 USA. RP Ostashev, VE (reprint author), NOAA, Earth Syst Res Lab, Boulder, CO 80305 USA. RI Wilson, D. Keith/A-4687-2012 OI Wilson, D. Keith/0000-0002-8020-6871 NR 19 TC 12 Z9 12 U1 0 U2 0 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2007 VL 122 IS 1 BP 107 EP 112 DI 10.1121/1.2743153 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 191WA UT WOS:000248161500009 PM 17614469 ER PT J AU Swearingen, ME White, MJ AF Swearingen, Michelle E. White, Michael J. TI Influence of scattering, atmospheric refraction, and ground effect on sound propagation through a pine forest SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID ATTENUATION AB Sound propagation through a forest is affected by the microclimate in the canopy, scattering by trunks and stems, and ground reflection. Each of these effects is such a strong contributor to the attenuation of sound that mutual interactions between the phenomena could become important. A sound propagation model for use in a forest has been developed that incorporates scattering from trunks and branches and atmospheric refraction by modifying the effective wave number in the Green's function parabolic equation model. The ground effect for a hard-backed pine straw layer is approximated as a local reaction impedance condition. Comparisons to experimental data are made for frequencies up to 4 200Hz. Cumulative influences of the separate phenomena are examined. The method developed in this paper is compared to previously published methods. The overall comparison with spectral transmission data is good, suggesting that the model captures the necessary details. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. RP Swearingen, ME (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. EM michelle.e.swearingen@erdc.usace.army.mil RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 16 TC 11 Z9 11 U1 1 U2 6 PU ACOUSTICAL SOC AMER AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUL PY 2007 VL 122 IS 1 BP 113 EP 119 DI 10.1121/1.2735108 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA 191WA UT WOS:000248161500010 PM 17614470 ER PT J AU Du, K Rood, MJ Kim, BJ Kemme, MR Franek, BJ Mattison, K Cook, J AF Du, Ke Rood, Mark J. Kim, Byung J. Kemme, Michael R. Franek, Bill J. Mattison, Kevin Cook, Joan TI Field evaluation of digital optical method to quantify the visual opacity of plumes SO JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION LA English DT Article ID PARTICULATE MATTER; COMPLIANCE SYSTEM; VISIBILITY AB Visual Determination of the Opacity of Emissions from Stationary Sources (Method 9) is a reference method established by U.S. Environmental Protection Agency (EPA) to quantify plume opacity. However, Method 9 relies on observations from humans, which introduces subjectivity. In addition, it is expensive to teach and certify personnel to evaluate plume opacity on a semiannual basis. In this study, field tests were completed during a "smoke school" and a 4-month monitoring program of plumes emitted from stationary sources with a Method 9 qualified observer to evaluate the use of digital photography and two computer algorithms as an alternative to Method 9. This Digital Optical Method (DOM) improves objectivity, costs less to implement than Method 9, and provides archival photographic records of the plumes. Results from "smoke school" tests indicate that DOM passed six of eight tests when the sun was located in the 140 degrees sector behind one of the three cameras, with the individual opacity errors of 15% or less and average opacity errors of 7.5% or less. DOM also passed seven of the eight tests when the sun was located in the 216 degrees sector behind another camera. However, DOM passed only one of the eight tests when the sun was located in the 116 degrees sector in front of the third camera. Certification to read plume opacity by a "smoke reader" for 6 months requires that the "smoke reader" pass one of the smoke school tests during smoke school. The average opacity errors and percentage of observations with individual opacity errors above 15% for the results obtained with DOM were lower than those obtained by the smoke school trainees with the sun was located behind the camera, whereas they were higher than the smoke school trainee results with the sun located in front of the camera. In addition, the difference between plume opacity values obtained by DOM and a Method 9 qualified observer, as measured in the field for two industrial sources, were 2.2%. These encouraging results demonstrate that DOM is able to meet Method 9 requirements under a wide variety of field conditions and, therefore, has potential to be used as an alternative to Method 9. C1 Univ Illinois, Dept Civil & Environm Engn, Newmark Civil Engn Lab 3213, Urbana, IL 61801 USA. USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61824 USA. Illinois Environm Protect Agcy, Des Plaines, IL USA. Texas Commiss Environm Qual, Austin, TX USA. RP Rood, MJ (reprint author), Univ Illinois, Dept Civil & Environm Engn, Newmark Civil Engn Lab 3213, 205 N Mathews Ave, Urbana, IL 61801 USA. EM mrood@uiuc.edu RI Du, Ke/A-6649-2012 NR 21 TC 7 Z9 7 U1 2 U2 6 PU AIR & WASTE MANAGEMENT ASSOC PI PITTSBURGH PA ONE GATEWAY CENTER, THIRD FL, PITTSBURGH, PA 15222 USA SN 1047-3289 J9 J AIR WASTE MANAGE JI J. Air Waste Manage. Assoc. PD JUL PY 2007 VL 57 IS 7 BP 836 EP 844 DI 10.3155/1047-3289.57.7.836 PG 9 WC Engineering, Environmental; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 186GD UT WOS:000247766200008 PM 17687999 ER PT J AU Rupp, TL Balkin, TJ AF Rupp, Tracy L. Balkin, Thomas J. TI An unfounded conclusion from a confounded study SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE LA English DT Letter ID SLEEPINESS C1 Walter Reed Army Inst Res, Silver Spring, MD USA. RP Rupp, TL (reprint author), Walter Reed Army Inst Res, Silver Spring, MD USA. RI Rupp, Tracy/B-3605-2011 NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER BOARD FAMILY MEDICINE PI LEXINGTON PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA SN 1557-2625 J9 J AM BOARD FAM MED JI J. Am. Board Fam. Med. PD JUL-AUG PY 2007 VL 20 IS 4 BP 420 EP 420 DI 10.3122/jabfm.2007.04.070061 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 186MV UT WOS:000247783700014 PM 17615426 ER PT J AU Bhagwat, MJ Moulton, MA Caradonna, FX AF Bhagwat, Mahendra J. Moulton, Marvin A. Caradonna, Francis X. TI Development of a CFD-based hover performance prediction tool for engineering analysis SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB This paper concerns the development of a second -generation implementation of the vorticity embedding method for the prediction of rotor hover performance. The basic method, encoded in the HELIX-IA code, is an Eulerian-Lagrangian, computational fluid dynamics (CFD)-based procedure that utilizes an Eulerian potential flow solution combined with a Lagrangian wake convection. The blade(s) can be represented either as a lifting-surface or as a lifting-line with a specified circulation (loading) distribution. Furthermore, the basic method is hybridized with a Reynolds averaged Navier-Stokes (RANS) code, TURNS. The HELIX-IA code provides the wake convection and associated induced inflow while the TURNS code provides the surface viscous flow. The method is grid point efficient because the CFD solver is not burdened with resolving the entire shed wake. The importance of recent enhancements to the basic HELIX-IA methodology is demonstrated by a good comparison of predictions (performance, loading and wake trajectory) with available model scale data. Application of the new hybrid option of HELIX-IA to the UH-60A Black Hawk rotor provides a first demonstration of this method. Convergence of the hybrid solution is good, showing the basic viability of the approach. Preliminary computations show a strong dependence of wake trajectory on tip loading, and the need for tip grid improvement in order to attain better accuracy. C1 ELORET Corp, Ames Res Ctr, Moffett Field, CA USA. USA, AMRDEC, Aviat Engn Directorate, Redstone Arsenal, AL 35898 USA. USA, AMRDEC, Aeroflightdynam Directorate, AMRDEC, Moffett Field, CA USA. RP Bhagwat, MJ (reprint author), ELORET Corp, Ames Res Ctr, Moffett Field, CA USA. EM bliagwat@merlin.arc.nasa.gov NR 12 TC 6 Z9 6 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2007 VL 52 IS 3 BP 175 EP 188 PG 14 WC Engineering, Aerospace SC Engineering GA 194CE UT WOS:000248320700001 ER PT J AU Floros, MW Johnson, W AF Floros, Matthew W. Johnson, Wayne TI Stability and control analysis of the slowed-rotor compound helicopter configuration SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article; Proceedings Paper CT 60th Annual Forum of the American-Helicopter-Society CY JUN 07-10, 2004 CL Baltimore, MD SP Amer Helicopter Soc AB Stability and control of rotors at high advance ratio are considered. Stability of teetering, articulated, and gimbaled hub types is considered with a simple flapping blade analysis. Rotor control in autorotation for teetering and articulated hub types is examined in more detail for a compound helicopter (rotor and fixed wing) using the comprehensive analysis CAMRAD II. Autorotation is found to be possible at two distinct trim conditions with different sharing of lift between the rotor and wing. Stability predictions obtained using the analytical rigid flapping blade analysis and a rigid blade CAMRAD II model compare favorably. For the flapping blade analysis, the teetering rotor is found to be the most stable hub type, showing no instabilities up to an advance ratio of 3 and a Lock number of 18. Analysis of the trim controls, lift, power, and blade flapping shows that for small positive collective pitch, trim can be maintained without excessive control input or flapping angles for both teetering and articulated rotors. C1 USA, Res Lab, Hampton, VA USA. NASA, Ames Res Ctr, Aeromech Branch, Moffett Field, CA 94035 USA. RP Floros, MW (reprint author), USA, Res Lab, Hampton, VA USA. EM matt.floros@us.anny.mil NR 12 TC 6 Z9 9 U1 1 U2 5 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 USA SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 2007 VL 52 IS 3 BP 239 EP 253 PG 15 WC Engineering, Aerospace SC Engineering GA 194CE UT WOS:000248320700006 ER PT J AU Vorontsov, MA Kolosov, VV Kohnle, A AF Vorontsov, Mikhail A. Kolosov, Valeriy V. Kohnle, Anton TI Adaptive laser beam projection on an extended target: phase- and field-conjugate precompensation SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID TURBULENT ATMOSPHERE; SPECKLE-FIELD; OPTICS; COMPENSATION; DISTORTION; SUPERRESOLUTION; PROPAGATION; SYSTEMS; IMAGE; MEDIA AB The problem of adaptive laser beam projection onto an extended object (target) having a randomly rough surface in an optically inhomogeneous medium (atmosphere) is analyzed. Outgoing beam precompensation is considered through conjugation of either the target-return wave phase or the complex field. It is shown that in the presence of "frozen" turbulence, both phase-conjugate (PC) and field-conjugate (FC) precompensation can result in a superfocusing effect, which suggests the possibility of achieving a brighter target hit spot in volume turbulence than in vacuum. This superfocusing effect is significantly more distinct for FC precompensation. In the quasi-stationary case (slowly moving turbulence or target), PC and FC beam control lead to enhanced intensity fluctuations at the target surface associated with intermittent formation and disintegration of bright target hit spots that sporadically attach to the extended target surface. This intensity fluctuation level exceeds intensity fluctuations in the absence of beam control and is higher for FC precompensation. In the nonstationary case, both PC and FC lead to an increase of beam width and centroid wander at the extended target surface compared with conventional projection of a collimated or focused beam. (c) 2007 Optical Society of America. C1 USA, Res Lab, Computat & Informat Sci Directorate, Intelligent Opt Lab, Adelphi, MD 20783 USA. Univ Maryland, Syst Res Inst, College Pk, MD 20740 USA. Russian Acad Sci, Inst Atmospher Opt, Siberian Branch, Tomsk 634055, Russia. Res Inst Optron & Pattern Recognit FGAN FOM, Dept Atmospher Opt & Meteorol, D-76275 Ettlingen, Germany. RP Vorontsov, MA (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, Intelligent Opt Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM mvorontsov@arl.army.mil NR 46 TC 22 Z9 22 U1 2 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1084-7529 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD JUL PY 2007 VL 24 IS 7 BP 1975 EP 1993 DI 10.1364/JOSAA.24.001975 PG 19 WC Optics SC Optics GA 189ES UT WOS:000247972800019 PM 17728822 ER PT J AU Garcia, MA Losurdo, M Wolter, SD Kim, TH Lampert, WV Bonaventura, J Bruno, G Giangregorio, M Brown, A AF Garcia, Michael A. Losurdo, Maria Wolter, Scott D. Kim, Tong-Ho Lampert, W. V. Bonaventura, Joseph Bruno, Giovanni Giangregorio, Maria Brown, April TI Functionalization and characterization of InAs and InP surfaces with hemin SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 34th Annual Conference on the Physics and Chemistry of Semiconductor Interfaces CY JAN 14-18, 2007 CL Salt Lake City, UT SP USA Res Off, Off Naval Res, Amer Vacuum Soc, Elect Mat & Proc Div ID RAY-PHOTOELECTRON-SPECTROSCOPY; NITRIC-OXIDE; ACID DERIVATIVES; GAAS; IRON; PARAMETERS; COMPLEXES; SPECTRA; INSB; ESCA AB Chemical functionalization of hemin molecules onto InAs and InP is reported. X-ray photoelectron spectroscopy (XPS), atomic force microscopy, and spectroscopic ellipsometry (SE) analyses are used to characterize the III-V surfaces. One notable feature of the C 1s core level spectra is a peak at similar to 284 eV observed for the functionalization chemistries, which is attributed to C = N bonding within the porphyrin molecule. This is corroborated by the observation of N Is, Fe 2p, and other distinguishable chemical bonding peaks. For example, in the As 3d and P 2p core levels, -COOH bonding is observed to the As and P anion in the InAs and InP samples, respectively, which implies chemisorption of the functional groups to the material surfaces. Another result of the XPS analysis is the impact of the surface functional group on the electronic state of the surface causing upward band bending of the valence band maximum, indicating surface charge transfer as explored in previous work [Garcia et al., Appl. Phys. Lett. 88, 013506 (2006)]. SE analysis on the functionalization process provides data for the effect of hemin and benzoic acid solution concentrations. The authors discuss the dependence of the band bending, surface coverage, and hemin layer thickness as determined by XPS and SE. 0 2007 American Vacuum Society. C1 Duke Univ, Dept Elect & Comp Engn, Res Triangle Pk, NC 27709 USA. CNR, IMIP, I-70126 Bari, Italy. INSTM, I-70126 Bari, Italy. USA, Res Off, Res Triangle Pk, NC 27709 USA. Duke Univ, Med Ctr, Nicholas Sch Environm, Durham, NC 27710 USA. RP Garcia, MA (reprint author), Duke Univ, Dept Elect & Comp Engn, Res Triangle Pk, NC 27709 USA. EM mag18@duke.edu OI GIANGREGORIO, MARIAMICHELA/0000-0002-4605-1546; LOSURDO, MARIA/0000-0002-8008-5192; BRUNO, GIOVANNI/0000-0003-3116-1176 NR 31 TC 16 Z9 16 U1 0 U2 13 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL-AUG PY 2007 VL 25 IS 4 BP 1504 EP 1510 DI 10.1116/1.2746337 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA 206FU UT WOS:000249170100069 ER PT J AU Wahl-Jensen, V Chapman, J Asher, L Fisher, R Zimmerman, M Larsen, T Hooper, JW AF Wahl-Jensen, Victoria Chapman, Jennifer Asher, Ludmila Fisher, Robert Zimmerman, Michael Larsen, Tom Hooper, Jay W. TI Temporal analysis of Andes virus and Sin Nombre virus infections of Syrian hamsters SO JOURNAL OF VIROLOGY LA English DT Article ID HANTAVIRUS PULMONARY SYNDROME; TO-PERSON TRANSMISSION; M GENOME SEGMENT; VERO E6 CELLS; CARDIOPULMONARY SYNDROME; NEUTRALIZING ANTIBODIES; NEPHROPATHIA-EPIDEMICA; HEMORRHAGIC-FEVER; APOPTOSIS; SHOCK AB Andes virus (ANDV) and Sin Nombre virus (SNV) are rodent-borne hantaviruses that cause a highly lethal hemorrhagic fever in humans known as hantavirus pulmonary syndrome (HPS). There are no vaccines or specific drugs to prevent or treat HPS, and the pathogenesis is not understood. Syrian hamsters infected with ANDV, but not SNV, develop a highly lethal disease that closely resembles HPS in humans. Here, we performed a temporal pathogenesis study comparing ANDV and SNV infections in hamsters. SNV was nonpathogenic and viremia was not detected despite the fact that all animals were infected. ANDV was uniformly lethal with a mean time to death of 11 days. The first pathology detected was lymphocyte apoptosis starting on day 4. Animals were viremic and viral antigen was first observed in multiple organs by days 6 and 8, respectively. Levels of infectious virus in the blood increased 4 to 5 logs between days 6 and 8. Pulmonary edema was first detected ultrastructurally on day 6. Ultrastructural analysis of lung tissues revealed the presence of large inclusion bodies and substantial numbers of vacuoles within infected endothelial cells. Paraendothelial gaps were not observed, suggesting that fluid leakage was transcellular and directly attributable to infecting virus. Taken together, these data imply that HPS treatment strategies aimed at preventing virus replication and dissemination will have the greatest probability of success if administered before the viremic phase; however, because vascular leakage is associated with infected endothelial cells, a therapeutic strategy targeting viral replication might be effective even at later times (e.g., after disease onset). C1 USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Vet Med Div, Ft Detrick, MD 21702 USA. RP Hooper, JW (reprint author), USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. EM jay.hooper@amedd.army.mil OI Hooper, Jay/0000-0002-4475-0415 FU NCCIH NIH HHS [Z01 AT000002, R01 AT000002] NR 44 TC 62 Z9 63 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUL PY 2007 VL 81 IS 14 BP 7449 EP 7462 DI 10.1128/JVI.00238-07 PG 14 WC Virology SC Virology GA 188UF UT WOS:000247944100012 PM 17475651 ER PT J AU Kobayashi, N Agarwal, A Johnson, BD AF Kobayashi, Nobuhisa Agarwal, Arpit Johnson, Bradley D. TI Longshore current and sediment transport on beaches SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID SURF-ZONE; SWASH ZONES; IRREGULAR WAVES AB A numerical model based on the time-averaged continuity, cross-shore momentum, longshore momentum, and energy equations is developed to predict the cross-shore variations of the mean and standard deviation of the free surface elevation and depth-averaged cross-shore and longshore velocities under obliquely incident irregular breaking waves. The suspended sediment volume per unit horizontal area is estimated using the computed energy dissipation rates due to wave breaking and bottom friction. The longshore suspended sediment transport rate is estimated as the product of the Ion-shore current and suspended sediment volume. The developed model is compared with limited field and laboratory data. The calibrated model is in fair agreement with the data. The longshore suspended sediment transport rate is shown to be approximately proportional to the square of the longshore current. The developed model appears promising but will need to be evaluated using extensive data sets. C1 Univ Delaware, Ctr Appl & Coastal Res, Newark, DE 19716 USA. Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA. USA, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Kobayashi, N (reprint author), Univ Delaware, Ctr Appl & Coastal Res, Newark, DE 19716 USA. EM nk@coastal.udel.edu NR 24 TC 20 Z9 20 U1 2 U2 8 PU ASCE-AMER SOC CIVIL ENGINEERS PI RESTON PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 2007 VL 133 IS 4 BP 296 EP 304 DI 10.1061/(ASCE)0733-950X(2007)133:4(296) PG 9 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA 180IU UT WOS:000247357200007 ER PT J AU Abadie, JM AF Abadie, Jude M. TI Laboratory perspectives on test ordering and interpretation: Or when is a cholesterol test better than a $5,400 send-out? SO LABMEDICINE LA English DT Article C1 Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Area Lab Serv, Washington, DC 20307 USA. RP Abadie, JM (reprint author), Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CLINICAL PATHOLOGY PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA SN 0007-5027 J9 LABMEDICINE JI Labmedicine PD JUL PY 2007 VL 38 IS 7 BP 401 EP 403 DI 10.1309/R9NEJWUP74KQ4A8V PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 184AF UT WOS:000247612800013 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Inferno: The fiery destruction of Hamburg, 1943. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400226 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The war: An intimate history, 1941-1945. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400228 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Death of the Wehrmacht: The German campaigns of 1942. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400224 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI No simple victory: World War II in Europe, 1939-1945. SO LIBRARY JOURNAL LA English DT Book Review RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400225 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The ghost mountain boys: The terrifying battle for Buna - The forgotten war of the South Pacific. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400223 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI The day of battle; The war in Sicily and Italy, 1943-1944. SO LIBRARY JOURNAL LA English DT Book Review C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400222 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI World War II SO LIBRARY JOURNAL LA English DT Editorial Material C1 USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA, Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 2007 VL 132 IS 12 BP 102 EP 102 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 187IQ UT WOS:000247841400221 ER PT J AU Steckl, AJ Park, JH Zavada, JM AF Steckl, Andrew J. Park, Jeong Ho Zavada, John M. TI Prospects for rare earth doped GaN lasers on Si SO MATERIALS TODAY LA English DT Review ID MOLECULAR-BEAM EPITAXY; SILICON RAMAN LASER; EU-IMPLANTED GAN; ROOM-TEMPERATURE; ENERGY LEVELS; PHOTOLUMINESCENCE; LUMINESCENCE; MECHANISMS; SUBSTRATE; EMISSION AB The recent surge of interest and research activity in Si-based lasers underscores the potential benefits that full capability in photonics could bring to the Si world. We highlight some of the recent advances in lasing based on emission from rare earth (RE) elements contained in GaN heteroepitaxially grown on Si. This approach has led to the first demonstration of visible lasing on Si. We discuss the current understanding of RE lasing sites in GaN, the intimate relationship between materials growth, optical properties and resulting laser performance. The eventual success of this approach will result in the availability of laser light sources built directly on Si substrates and operating at wavelengths throughout the visible and near-infrared (IR) range. The prospects and challenges for electrically pumped injection GaN:RE lasers, and potential applications, are discussed. C1 Univ Cincinnati, Nanoelect Lab, Cincinnati, OH 45221 USA. USA, Res Off, Durham, NC 27709 USA. RP Steckl, AJ (reprint author), Univ Cincinnati, Nanoelect Lab, Cincinnati, OH 45221 USA. EM a.steckl@uc.edu OI Steckl, Andrew/0000-0002-1868-4442 NR 38 TC 61 Z9 61 U1 3 U2 37 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1369-7021 J9 MATER TODAY JI Mater. Today PD JUL-AUG PY 2007 VL 10 IS 7-8 BP 20 EP 27 DI 10.1016/S1369-7021(07)70176-1 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA 184GC UT WOS:000247628100017 ER PT J AU Bhattacharjee, AK Nichols, DA Gerena, L Roncal, N Gutteridge, CE AF Bhattacharjee, A. K. Nichols, D. A. Gerena, L. Roncal, N. Gutteridge, C. E. TI An in silico 3D pharmacophore model of chalcones useful in the design of novel antimalarial agents SO MEDICINAL CHEMISTRY LA English DT Article DE in silico 3D pharmacophore; virtual screening; malaria; chalcone; design; novel antimalarial agents; quantitative structure activity relationship (QSAR) ID DIHYDROFOLATE-REDUCTASE INHIBITORS; PARASITE PLASMODIUM-FALCIPARUM; MEDICINAL CHEMISTRY; MALARIA; DERIVATIVES; VITRO; PROGRESS; INVITRO; GROWTH AB Malaria, the most important of the human parasitic diseases, causes about 500 million infections worldwide and over I million deaths every year. The search for novel drug candidates against specific parasitic targets is an important goal for antimalarial drug discovery. Recently the antimalarial activity of chalcones has generated great interest. These compounds are small non-chiral molecules with relative high lipophilicity (clogP similar to 5-7), have molecular weights in the range of 300 to 600 g/mol, and possess in vivo efficacy against both P. berghei and P. yeolii. Preliminary data on our ongoing chalcone synthesis project indicate that these compounds are active in vitro against P. falciparum, but are rapidly metabolized in liver microsome assays. Structurally-related compounds not including the enone linker are found to be much more metabolically stable and yet have comparable in vitro efficacy. In this study, we have utilized the efficacy data from an in-house on-going chalcone project to develop a 3D pharmacophore for antimalarial activity and used it to conduct virtual screening (in silico search) of a chemical library which resulted in identification of several potent chalcone-like antimalarials. The pharmacophore is found to contain an aromatic and an aliphatic hydrophobic site, one hydrogen bond donor site, and a ring aromatic feature distributed over a 3D space. The identified compounds were not only found to be potent in vitro against several drug resistant and susceptible strains of P. falciparum and have better metabolic stability, but included one with good in vivo efficacy in a mouse model of malaria. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. USN Acad, Dept Chem, Annapolis, MD 21402 USA. RP Bhattacharjee, AK (reprint author), Walter Reed Army Inst Res, Dept Med Chem, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM apurba.bhattacharjee@na.amedd.army.mil NR 58 TC 12 Z9 13 U1 0 U2 6 PU BENTHAM SCIENCE PUBL LTD PI SHARJAH PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES SN 1573-4064 J9 MED CHEM JI Med. Chem. PD JUL PY 2007 VL 3 IS 4 BP 317 EP 326 PG 10 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 209ZA UT WOS:000249425300001 PM 17627568 ER PT J AU Benedek, DM Schneider, BJ Bradley, JC Benedek, DM AF Benedek, David M. Schneider, Brett J. Bradley, John C. Benedek, David M. TI Psychiatric medications for deployment: An update SO MILITARY MEDICINE LA English DT Article AB Objective: This article discusses issues regarding the usage of psychotropic medications during military deployments, with emphasis on Operation Iraqi Freedom. Method: The role of psychotropic medications in the Army combat stress control doctrine is reviewed and compared with operational experiences of psychiatrists who have deployed to Iraq, Bosnia, and Egypt. Results: Many issues regarding psychotropic medications experienced by deployed psychiatrists are not discussed in the Army combat stress control doctrine. Conclusion: The advent of new psychotropic medications, the changes in the types of conflicts fought, and the role of National Guard and Reserve forces in current conflicts have all had an impact on the role and usage of psychotropic medications during military deployments. C1 Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. Walter Reed Army Med Ctr, Dept Psychiat, Washington, DC 20307 USA. RP Benedek, DM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD 20814 USA. NR 24 TC 6 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 681 EP 685 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100004 PM 17691678 ER PT J AU Cave, KM Cornish, EM Chandler, DW AF Cave, Kara M. Cornish, Elizabeth M. Chandler, David W. TI Blast injury of the ear: Clinical update from the global war on terror SO MILITARY MEDICINE LA English DT Article ID HEARING AB The purpose of this study was to describe the effects of blast exposure on hearing status. This study retrospectively analyzed hearing thresholds and otologic complaints for >250 patients with blast-related injuries from the global war on terror. Of patients who received full diagnostic evaluations, 32% reported a history of tympanic membrane perforation, 49% experienced tinnitus, 26% reported otalgia (ear pain), and 15% reported dizziness. Expected hearing thresholds were computed by applying age-correction factors to hearing tests performed earlier in the service members' careers and before their most recent deployment. Expected hearing thresholds were significantly better than actual postdeployment thresholds, indicating that significant changes occurred in the patients' hearing that could not be accounted for by age. Results from this study underline the need for documentation of pre-and postdeployment hearing tests and prompt otologic evaluation for the blast-exposed population. C1 USA, Ballist Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. Madigan Army Med Ctr, Dept Audiol, Tacoma, WA 98431 USA. Off Surg Gen, Falls Church, VA 22041 USA. RP Cave, KM (reprint author), USA, Ballist Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. NR 21 TC 57 Z9 60 U1 0 U2 5 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 726 EP 730 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100011 PM 17691685 ER PT J AU Scherer, M Burrows, H Pinto, R Somrack, E AF Scherer, Matthew Burrows, Holly Pinto, Robin Somrack, Elizabeth TI Characterizing self-reported dizziness and otovestibular impairment among blast-injured traumatic amputees: A pilot study SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 17th Annual Convention of the American-Academy-of-Audiology CY APR, 2005 CL Washington, DC SP Amer Acad Audiol ID DYNAMIC VISUAL-ACUITY; VESTIBULAR HYPOFUNCTION; HEAD-INJURY; REHABILITATION AB The incidence of vestibular and audiologic injury related to blast injury remains underreported. The primary objective of this study was to document self-reported otovestibular impairment in blast-injured amputees. Secondary objectives include a description of the Walter Reed Army Medical Center Blast Injury questionnaire and other aspects of the audiology service and amputee physical therapy section standards of care for blast injury management. A case study illustrates the application of these standards of care. Thirty-three patients were evaluated by audiologists and physical therapists using the Walter Reed Army Medical Center Blast Injury questionnaire, followed by audiologic and vestibular screening; 24% of patients reported symptoms of vertigo or oscillopsia following blast trauma, and 51% reported subjective hearing loss. The case study subject reported an increase in function after vestibular rehabilitation therapy. Thorough screening by audiologists and physical therapists can facilitate appropriate diagnosis and management for blast-injured patients. C1 Walter Reed Army Med Ctr, Phys Therapy Serv, Dept Orthoped & Rehabil, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Audiol Serv, Washington, DC 20307 USA. Madigan Army Med Ctr, Audiol Serv, Tacoma, WA 98431 USA. RP Scherer, M (reprint author), Walter Reed Army Med Ctr, Phys Therapy Serv, Dept Orthoped & Rehabil, 6900 Georgia Ave, Washington, DC 20307 USA. NR 22 TC 17 Z9 18 U1 1 U2 4 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 731 EP 737 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100012 PM 17691686 ER PT J AU Ricciardi, R Deuster, PA Talbot, LA AF Ricciardi, Richard Deuster, Patricia A. Talbot, Laura A. TI Effects of gender and body adiposity on physiological responses to physical work while wearing body armor SO MILITARY MEDICINE LA English DT Article ID LOAD-CARRIAGE; PERCEIVED EXERTION; MASS INDEX; TREADMILL WALKING; EXERCISE; PERFORMANCE; THRESHOLD; LACTATE; WOMEN; FAT AB The purpose of this study was to identify the effects of gender and body adiposity on physiological responses to the stress of wearing body armor. Using a within-subject, repeated-measures design, 37 military personnel volunteered to undergo two experimental conditions, with body armor and without body armor. Female and male subjects with body armor, compared to those without body armor, had no significant differences in percentage increases in aerobic capacity, heart rate, or respiratory rate while walking at slow or moderate pace. However, women, as compared to men, had a significantly increased difference in the rating of perceived physical exertion between wearing and not wearing body armor at a slow pace. Fourteen subjects were not able to complete treadmill testing while wearing body armor because of volitional fatigue and/or limiting dyspnea. Body fat was the best single predictor of treadmill test completion. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, Bethesda, MD 20814 USA. RP Ricciardi, R (reprint author), Walter Reed Army Med Ctr, Washington, DC 20307 USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 46 TC 13 Z9 14 U1 1 U2 5 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 743 EP 748 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100014 PM 17691688 ER PT J AU Feldman, RL Nickell, K AF Feldman, Robert L. Nickell, Kent TI Avian influenza: Potential impact on sub-Saharan military populations with high rates of human immunodeficiency virus/acquired immunodeficiency syndrome SO MILITARY MEDICINE LA English DT Article AB Several sub-Saharan militaries have large percentages of troops with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome. With the arrival of avian influenza in Africa, the potential exists that some of those soldiers might also become infected with H5N1, the virus responsible for the disease. Two possible scenarios have been postulated regarding how such a coinfection of HIV and H5N1. might present. (1) Soldiers already weakened by HIV/acquired immunodeficiency syndrome rapidly succumb to H5N1. The cause of death is a cytokine storm," essentially a runaway inflammatory response. (2) The weakened immune system prevents the cytokine storm from occurring; however, H5N1 is still present, replicating, and being shed, leading to the infection of others. A cytokine storm is particularly dangerous for individuals of military age, as evidenced by the large number of soldiers who died during the 1918 influenza epidemic. If large numbers of sub-Saharan soldiers suffer a similar fate from avian influenza, then military and political instability could develop. C1 Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA. Allen Mem Hosp, Dept Pathol, Waterloo, IA 50703 USA. RP Feldman, RL (reprint author), Foreign Mil Studies Off, Ft Leavenworth, KS 66027 USA. NR 33 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 753 EP 758 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100016 PM 17691690 ER PT J AU Kim, HC Klein, TA Chong, ST Collier, BW Yi, SC Song, KJ Baek, LJ Song, JW AF Kim, Heung-Chul Klein, Terry A. Chong, Sung-Tae Collier, Brett W. Yi, Song Chu Song, Ki-Joon Baek, Luck-Ju Song, Jin-Won TI Seroepidemiological survey of rodents collected at a US military installation, Yongsan Garrison, Seoul, Republic of Korea SO MILITARY MEDICINE LA English DT Article ID HEMORRHAGIC-FEVER; ETIOLOGIC AGENT; HANTAAN VIRUS AB A seroepidemiological study of selected rodent-borne diseases (hantavirus [Seoul [SEO] virus], scrub typhus [Orientia tsutsugamushi], murine typhus [Rickettsia typhil, and leptospirosis [Leptospira interrogans]), as part of the U.S. military rodent surveillance and control program, was conducted from 2001 through 2005 at Yongsan Garrison, Seoul, Republic of Korea. Rodents were collected to determine the prevalence of rodent-borne diseases at a U.S. military installation in an urban environment. A total of 1,750 rodents representing three species was collected by using baited live traps (Tomahawk), glue boards, and poison baits (dead rodents observed but not assayed). The Norway rat, Rattus norvegicus (99.8%), accounted for nearly all of the rodents captured/observed. Only three roof rats, Rattus rattus (0.2%), and one house mouse, Mus musculus (<0.1%), were collected. R. norvegicus rats were the only rodents that were serologically positive for SEO virus (9.6%), scrub typhus (2.8%), murine typhus (3.8%), and leptospirosis (4.6%). One of six rodents that were positive for SEO virus by immunofluorescent antibody test was positive for SEO virus antigen by reverse transcriptase-polymerase chain reaction. Infection rates for SEO virus, scrub typhus, murine typhus, and leptospirosis varied annually. Rodents were captured from 228 (20.7%) of 1,104 total buildings in Yongsan Garrison. The Yongsan commissary had the highest annual infestation rate (22 rodents per year), followed by Commisky's Club (18 rodents per year). Annual infestation rates were high for food service facilities, which often store perishable food products outdoors for short periods of time, attracting rodent populations; refuse from these facilities provides harborage and food for rodents. The effect of rodent populations outside the boundary of Yongsan Garrison was not determined. C1 USA, Med Command 18, Med Battalion 168, Med Detachment 5,U15247, APO, AP 96205 USA. USA, Med Command 18, U15281, APO, AP 96205 USA. Installat Management Agcy, Korea Reg Off, Environm Branch, APO, AP 96205 USA. Korea Univ, Coll Med, Dept Microbiol, Seoul 136705, South Korea. RP Kim, HC (reprint author), USA, Med Command 18, Med Battalion 168, Med Detachment 5,U15247, APO, AP 96205 USA. RI Valle, Ruben/A-7512-2013 NR 16 TC 9 Z9 10 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 759 EP 764 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100017 PM 17691691 ER PT J AU Wood, BJ Gaydos, JC Mckee, KT Gaydos, CA AF Wood, Billie Jo Gaydos, Joel C. Mckee, Kelly T. Gaydos, Charlotte A. TI Comparison of the urine Leukocyte Esterase Test to a nucleic acid amplification test for screening non-health care-seeking male soldiers for Chlamydia trachomatis and Neisseria gonorrhoeae infections SO MILITARY MEDICINE LA English DT Article ID ADOLESCENT MALES; ASYMPTOMATIC MEN; DIAGNOSIS AB We evaluated the Leukocyte Esterase Test (LET) as a screening tool by testing urine from 1,438 non-health care-seeking male Army basic trainees with LET and a Nucleic Acid Amplification Test. Compared to Nucleic Acid Amplification Test results, LET sensitivity and specificity for detection of chlamydia and gonorrhea were 45.8% and 97.4%, and 60.0% and 96.2%, respectively. The prevalence of chlamydia and gonorrhea was 3.3% and 0.3%, respectively. In this population, the prevalence of gonorrhea was too low to produce reliable estimates of performance characteristics of the LET for gonorrhea. The LET is not warranted for use in screening non-health care-seeking male Army trainees. C1 Johns Hopkins Univ, Baltimore, MD 21205 USA. Walter Reed Army Inst Res, Dept Defense Global Emerging Infect Surveillance, Silver Spring, MD 20910 USA. Sci Serv Quintiles Inc, Morrisville, NC 27560 USA. RP Wood, BJ (reprint author), Johns Hopkins Univ, 720 Rutland Ave,Ross 1164, Baltimore, MD 21205 USA. RI Gaydos, Charlotte/E-9937-2010; Valle, Ruben/A-7512-2013 NR 15 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 770 EP 772 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100019 PM 17691693 ER PT J AU Nevin, RL Niebuhr, DW AF Nevin, Remington L. Niebuhr, David W. TI Rising hepatitis A immunity in US military recruits SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 54th Annual Meeting of the American-Society-for-Tropical-Medicine-and-Hygiene CY DEC 11-15, 2005 CL Washington, DC SP Amer Soc Trop Med & Hyg ID UNITED-STATES; B IMMUNITY; VACCINATION; IMMUNIZATION; HEALTH AB Background: The U.S. military immunizes new recruits against hepatitis A. Since 2001, immunization with the hepatitis A vaccine has been recommended for civilian adolescents in higher risk areas. Recently, the Armed Forces Epidemiological Board recommended serologic screening where feasible to reduce redundant recruit immunizations. Objectives: The purpose of this study was to determine hepatitis A seroprevalence in recruit populations to inform screening policy. Methods: Banked serum from a sample of military recruits (n = 2,592) in 2004 was tested for total antibody to hepatitis A (anti-hepatitis A virus (HAV)). Results: The overall anti-HAV seroprevalence was 12.0% (95% confidence interval, 10.8%-13.3%). Adjusted to the age distribution of the 18- to 34-year-old population, the seroprevalence was 11.9% (10.5%-13.4%). The lowest seroprevalence was noted in the 1984 birth cohort, with significantly higher seroprevalence among younger recruits. Conclusions: Rising hepatitis A immunity among successive birth cohorts suggests increasing compliance with immunization recommendations. In anticipation of rising population immunity, universal screening of military recruits for anti-HAV is recommended. C1 USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Div Prevent Med, Dept Epidemiol, Silver Spring, MD 20910 USA. RP Nevin, RL (reprint author), USA, Ctr Hlth Promot & Prevent Med, Silver Spring, MD 20910 USA. RI Niebuhr, David/B-7865-2011; OI Nevin, Remington/0000-0002-0534-1889 NR 29 TC 3 Z9 3 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 2007 VL 172 IS 7 BP 787 EP 793 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 189SZ UT WOS:000248010100023 PM 17691697 ER PT J AU Mohamadzadeh, M Chen, LP Schmaljohn, AL AF Mohamadzadeh, Mansour Chen, Lieping Schmaljohn, Alan L. TI How Ebola and Marburg viruses battle the immune system SO NATURE REVIEWS IMMUNOLOGY LA English DT Review ID EQUINE ENCEPHALITIS-VIRUS; PROTECT GUINEA-PIGS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; T-LYMPHOCYTES; VACCINE PROTECTS; DENDRITIC CELLS; INFLAMMATORY RESPONSES; VIRION GLYCOPROTEINS; FILOVIRUS INFECTIONS AB The filoviruses Ebola and Marburg have emerged in the past decade from relative obscurity to serve now as archetypes for some of the more intriguing and daunting challenges posed by such agents. Public imagination is captured by deadly outbreaks of these viruses and reinforced by the specter of bioterrorism. As research on these agents has accelerated, it has been found increasingly that filoviruses use a combination of familiar and apparently new ways to baffle and battle the immune system. Filoviruses have provided thereby a new lens through which to examine the immune system itself. C1 USA, Med Res Inst Infect Dis, Frederick, MD USA. Johns Hopkins Univ, Sch Med, Baltimore, MD USA. RP Mohamadzadeh, M (reprint author), USA, Med Res Inst Infect Dis, Frederick, MD USA. EM Mansour.mohamadzadeh@amedd.army.mil; Alan.Schmaljohn@amedd.army.mil NR 112 TC 65 Z9 69 U1 7 U2 60 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1474-1733 J9 NAT REV IMMUNOL JI Nat. Rev. Immunol. PD JUL PY 2007 VL 7 IS 7 BP 556 EP 567 DI 10.1038/nri2098 PG 12 WC Immunology SC Immunology GA 183UI UT WOS:000247597300017 PM 17589545 ER PT J AU Heaton, KJ Palumbo, CL Proctor, SP Killiany, RJ Yurgelun-Todd, DA White, RF AF Heaton, Kristin J. Palumbo, Carole L. Proctor, Susan P. Killiany, Ronald J. Yurgelun-Todd, Deborah A. White, Roberta F. TI Quantitative magnetic resonance brain imaging in US army veterans of the 1991 Gulf War potentially exposed to sarin and cyclosarin SO NEUROTOXICOLOGY LA English DT Article DE magnetic resonance imaging; morphometric analyses; brain; central nervous system; chemical warfare agents; sarin; cyclosarin; Gulf War veterans; khamisiyah; Iraq ID POSTTRAUMATIC-STRESS-DISORDER; CHEMICAL MUNITIONS DESTRUCTION; WHITE-MATTER CHANGES; LOW-LEVEL EXPOSURE; HIPPOCAMPAL VOLUME; MAJOR DEPRESSION; MR SPECTROSCOPY; NERVOUS-SYSTEM; GUINEA-PIGS; KHAMISIYAH AB Background: In March 1991, a munitions storage complex at Khamisiyah, Iraq was destroyed, potentially exposing more than 100,000 US troops to low levels of the organophosphate nerve agents sarin and cyclosarin. Little is known about the neurophysiological effects of low-dose exposure to sarin/cyclosarin in humans, although some research has indicated subtle but persistent neurobehavioral and neurochemical changes in individuals exposed to sarin/cyclosarin at levels insufficient to produce obvious clinical symptoms. However, the neuroanatomical correlates of these changes are unclear. The current study examined the association between modeled estimates of sarin/cyclosarin exposure levels and volumetric measurements of gross neuroanatomical structures in 1991 Gulf War veterans with varying degrees of possible low-level sarin/cyclosarin exposure. Methods: Twenty-six GW-deployed veterans recruited from the Devens Cohort Study participated. Magnetic resonance images of the brain were acquired and analyzed using morphometric techniques, producing volumetric measurements of white matter, gray matter, right and left lateral ventricles, and cerebrospinal fluid. Volumetric data were analyzed using exposure estimates obtained from refined models of the 1991 Khamisiyah presumed exposure hazard area. Results: Binary comparisons of sarin/cyclosarin 'exposed' (N = 13) and 'unexposed' (N = 13) veterans revealed no differences in volumetric measurements of discrete brain tissues. However, linear trend analyses showed a significant association between higher levels of estimated sarin/cyclosarin exposure and both reduced white matter (adjusted parameter estimate = -4.64, p < 0.0001) and increased right lateral ventricle (adjusted parameter estimate = .11, p = 0.0288) and left lateral ventricle (adjusted parameter estimate =.13, p < 0.0001) volumes. Conclusions: These findings suggest subtle but persistent central nervous system pathology in Gulf War veterans potentially exposed to low levels of sarin/cyclosarin and argue for further investigation of the long-term effects of low-dose sarin/cyclosarin exposures in humans. (c) 2007 Elsevier Inc. All rights reserved. C1 USA, Environm Med Res Inst, Med Performance Div, Mil Performance Div, Natick, MA 01760 USA. Boston Environm Hazards Res Ctr, VA Boston Healthcare Syst, Boston, MA USA. Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA. Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA. Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA. McLean Hosp, Brain Imaging Ctr, Belmont, MA 02178 USA. RP Heaton, KJ (reprint author), USA, Environm Med Res Inst, Med Performance Div, Mil Performance Div, Bldg 42,Kansas St, Natick, MA 01760 USA. EM kristin.heaton@us.army.mil RI Heaton, Kristin/E-3660-2013 NR 65 TC 46 Z9 46 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0161-813X J9 NEUROTOXICOLOGY JI Neurotoxicology PD JUL PY 2007 VL 28 IS 4 BP 761 EP 769 DI 10.1016/j.neuro.2007.03.006 PG 9 WC Neurosciences; Pharmacology & Pharmacy; Toxicology SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology GA 202BC UT WOS:000248875500006 PM 17485118 ER PT J AU Hasan, S Ghosh, TK Prelas, MA Viswanath, DS Boddu, VM AF Hasan, Shameem Ghosh, Tushar K. Prelas, Mark A. Viswanath, Dabir S. Boddu, Veera M. TI Adsorption of uranium on a novel bioadsorbent-chitosan-coated perlite SO NUCLEAR TECHNOLOGY LA English DT Article DE chitosan; adsorption; uranium ID SEA-WATER; RECOVERY; SEAWATER; EXTRACTION; SORPTION; ADSORBENTS; RESINS; IONS; POLYMERS; KINETICS AB Chitosan was coated on an inert substrate, perlite, and was prepared as spherical beads for adsorption of uranium from aqueous solutions. The uptake capacity of chitosan-coated perlite beads for uranium varied from 98.9 to 149 000 mu g/g when the equilibrium concentration of uranium in the solution ranged from 11 ppb (11 mu g/L) to 1000 ppm (10 x 10(6) mu g/L) and the solution pH was 5. The adsorption capacity of chitosan-coated perlite beads for uranium decreased by 75% in the presence of 0.45 M NaCl, whereas the adsorption capacity decreased by 55% when TiO2 was added to the beads during their preparation. The adsorption capacity of TiO2-containing chitosan beads for uranium was found to be in the range of 2.5 to 40 mu g of uranium per gram of beads when the concentration of uranium was 39 to 734 mu g/f in the presence of 0.45 M NaCl. It was in the range of 18 to 302 mu g of uranium per gram of beads when the concentration was 990 to 47000 mu g/L in the presence of 0.45 M Na2CO3. Chitosan-coated beads were found to preferentially adsorb uranium, Cd, and Cr from a mixture containing these ions along with Sr and Cs. Only a negligible amount of Sr and Cs was adsorbed by chitosan-coated beads. The data suggest that the chitosan-coated beads can be used for both extraction of uranium from waste streams and also from a highly acidic medium such as a reprocessing stream that uses nitric acid. C1 Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. USA, Construct Engn Res Lab, Ctr Res Dev & Engn, Environm Proc Branch, Champaign, IL 61826 USA. RP Hasan, S (reprint author), Univ Missouri, Nucl Sci & Engn Inst, Columbia, MO 65211 USA. EM ghoshT@missouri.edu OI Prelas, Mark/0000-0002-6507-0689 NR 36 TC 10 Z9 13 U1 1 U2 9 PU AMER NUCLEAR SOCIETY PI LA GRANGE PK PA 555 N KENSINGTON AVENUE, LA GRANGE PK, IL 60526 USA SN 0029-5450 J9 NUCL TECHNOL JI Nucl. Technol. PD JUL PY 2007 VL 159 IS 1 BP 59 EP 71 PG 13 WC Nuclear Science & Technology SC Nuclear Science & Technology GA 186SJ UT WOS:000247798200005 ER PT J AU Davis, JE Edge, BL Chen, HC AF Davis, Jack E. Edge, Billy L. Chen, Hamn-Ching TI Investigation of unrestrained cylinders rolling in steady uniform flows SO OCEAN ENGINEERING LA English DT Article DE UXO; physical modeling; numerical models; hydrodynamics; RANS solver; PIV ID BOUNDARY-LAYER CONTROL; CIRCULAR-CYLINDER; WAVE-FORCES; PLANE BOUNDARY; LIFT; MOTIONS; WALL AB The goal of this study is to understand the movement of unexploded ordnance that may become unburied and forced by currents. Symmetrical, smooth, finite-length, unrestrained cylinders were studied in steady, uniform flows over a range of Reynolds numbers in a smooth-bottomed, horizontal flume. The study uses PIV tracking methods in the laboratory to identify the movement of ordnance simulated by unrestrained cylinders. The PIV is supported with a numerical analysis using a RANS flow solver. The simulations showed that at low Reynolds numbers the cylinders should roll at speeds near 70% of the free-stream flow. (c) 2006 Elsevier Ltd. All rights reserved. C1 Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Div, College Stn, TX 77843 USA. USA Corps Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Edge, BL (reprint author), Texas A&M Univ, Zachry Dept Civil Engn, Coastal & Ocean Div, College Stn, TX 77843 USA. EM b-edge@tamu.edu OI Edge, Billy/0000-0001-9291-3920 NR 35 TC 3 Z9 3 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD JUL PY 2007 VL 34 IS 10 BP 1431 EP 1448 DI 10.1016/j.oceaneng.2006.10.002 PG 18 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 183KF UT WOS:000247571000008 ER PT J AU Gupta, OP Weichel, ED Regillo, CD Fineman, MS Kaiser, RS Ho, AC McNamara, JA Vander, JF AF Gupta, Omesh P. Weichel, Eric D. Regillo, Carl D. Fineman, Mitchell S. Kaiser, Richard S. Ho, Allen C. McNamara, J. Arch Vander, James F. TI Postoperative complications associated with 25-gauge pars plana vitrectomy SO OPHTHALMIC SURGERY LASERS & IMAGING LA English DT Article; Proceedings Paper CT Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology CY APR 30-MAY 04, 2006 CL Ft Lauderdale, FL SP Assoc Res Vis & Ophthalmol ID SELF-SEALING SCLEROTOMIES; TRANSCONJUNCTIVAL VITRECTOMY; SURGERY; OUTCOMES; SYSTEM AB BACKGROUND AND OBJECTIVE: To report postoperative complications in eyes undergoing 25-gauge pars plana vitrectomy (PPV). PATIENTS AND METHODS: Seventy consecutive eyes that underwent 25-gauge PPV for various indications, including epiretinal membrane, non-clearing vitreous hemorrhage, and idiopathic macular hole, and had a minimum follow-up of 12 weeks were reviewed retrospectively. Main outcome measures included best-corrected Snellen visual acuity, intraocular pressure (IOP), intraoperative complications, and postoperative complications. RESULTS: The mean visual acuity improved from 20/368 preoperatively to 20/105 postoperatively (P < .00005). Intraoperative complications included retinal tears in 2 eyes (2.9%). Postoperative complications included cataract progression in 17 eyes (42.5%), cystoid macular edema exacerbation in 5 eyes (7.1%), and retinal detachment in I eye (1.4%). Postoperative day 1 IOP was statistically lower than preoperative IOP in fluid-filled eyes (P = .031) but not in eyes filled with intravitreal air (P =.30) or gas (P = .52). Sclerotomy sutures were required intraoperatively in 5 eyes (7.1%) and postoperative day I hypotony was noted in 4 eyes (5.7%). All of these complications were noted in fluid-filled eyes except for one case of postoperative day 1 hypotony with gas tamponade. CONCLUSIONS: Intraoperative and postoperative complications were rare in this series of 25-gauge PPV. Postoperative cataract progression and hypotony were the most common complications. Fluid-filled eyes appear to have a higher risk of wound leakage and postoperative hypotony after 25-gauge PPV than eyes with air or gas tamponade. C1 Thomas Jefferson Univ, Retina Serv, Philadelphia, PA 19107 USA. Walter Reed Army Med Ctr, Dept Ophthalmol, Washington, DC 20307 USA. RP Regillo, CD (reprint author), Wills Eye Inst, 840 Walnut St,Suite 1020, Philadelphia, PA 19107 USA. NR 13 TC 67 Z9 70 U1 0 U2 3 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 1542-8877 J9 OPHTHAL SURG LAS IM JI Ophthalmic Surg. Lasers Imaging PD JUL-AUG PY 2007 VL 38 IS 4 BP 270 EP 275 PG 6 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA 193TT UT WOS:000248298400001 PM 17674916 ER PT J AU Nguyen, L Le, C Gaunaurd, GC AF Nguyen, Lam Le, Calvin Gaunaurd, Guillermo C. TI Computerized tomographic radar target imaging behind opaque walls SO OPTICAL ENGINEERING LA English DT Article DE scattering; imaging; ultrawideband radar; synthetic aperture radar (SAR); computer-aided tomography (CAT); X-Patch ID SYNTHETIC-APERTURE RADAR; SIGNAL-PROCESSING TECHNIQUES; BAND; RECONSTRUCTION AB The paper deals with the computer-aided tomographic reconstruction of radar images of objects behind opaque dielectric walls that are illuminated by microwave radiation emerging from moving ultrawide-band (UWB) radars. Tomographic techniques such as filtered backprojections are used here, in conjunction with some available electromagnetic computational codes such as X-Patch, to create the desired target images. The use of UWB radars to penetrate through the walls and image the objects behind them is novel and of obvious desirability. It is only possible if the walls are not too thick and not too lossy. In the present work, several wall types of different dielectric compositions and thicknesses are used to simulate a room that encloses two human targets placed at specified locations. The UWB radar moves along the room's front wall in a straight path with its beams directed normal to the wall and pointing towards its interior. Some basic principles of classical tomography are reviewed, and the reconstruction process via the X-Patch computational code and present-day backprojection techniques is completed for all the walls and targets here considered. This simulation demonstrates that under the specified conditions, the reconstruction of the radar images of the two humans is clearly achievable in all but in very adverse conditions. Furthermore, the dimensions and wall characteristics of the rooms can be estimated from the resulting radar images. (c) 2007 Society of Photo-Optical Instrumentation Engineers. C1 Army Res Lab, Adelphi, MD 20783 USA. RP Gaunaurd, GC (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM GGaunaurd@arl.army.mil NR 34 TC 5 Z9 7 U1 0 U2 3 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUL PY 2007 VL 46 IS 7 AR 076201 DI 10.1117/1.2757199 PG 10 WC Optics SC Optics GA 221BA UT WOS:000250200700031 ER PT J AU Yelleswarapu, CS Philip, R Aranda, FJ Kimball, BR Rao, DVGLN AF Yelleswarapu, Chandra S. Philip, Reji Aranda, Francisco J. Kimball, Brian R. Rao, D. V. G. L. N. TI Slow light in bacteriorhodopsin solution using coherent population oscillations SO OPTICS LETTERS LA English DT Article AB Slow light is demonstrated in liquid phase in an aqueous bacteriorhodopsin (bR) solution at room temperature. Group velocity as low as 3 m/s (all the way to c) is achieved by exploiting the photaisomerization property of bR for coherent population oscillations. Slow light in the liquid phase offers several advantages over solids or vapors for a variety of applications: W shorter lifetimes of the M state facilitate slow light at higher modulation frequencies, (ii) convection makes it possible to obtain large signal delays even at high input powers, and (iii) solution concentration is another convenient parameter to vary the signal delay over a wide range. (c) 2007 Optical Society of America. C1 Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. Raman Res Inst, Bangalore 560080, Karnataka, India. USA, Natick Soldier Ctr, Nanomat Sci Team, Natick, MA 01760 USA. RP Rao, DVGLN (reprint author), Univ Massachusetts, Dept Phys, Boston, MA 02125 USA. EM raod@umb.edu RI Philip, Reji/E-6721-2012; Yelleswarapu, Chandra/C-4392-2011; Rao, Devulapalli/L-8863-2015 NR 12 TC 11 Z9 12 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUL 1 PY 2007 VL 32 IS 13 BP 1788 EP 1790 DI 10.1364/OL.32.001788 PG 3 WC Optics SC Optics GA 194MK UT WOS:000248348300008 PM 17603570 ER PT J AU Bolger, WE Joshi, AS Spear, S Nelson, M Govindaraj, K AF Bolger, William E. Joshi, Arjun S. Spear, Samuel Nelson, Michael Govindaraj, Krishnamurthy TI Gene expression analysis in sinonasal polyposis before and after oral corticosteroids: A preliminary investigation SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID ASTHMA AB OBJECTIVE: To characterize gene expression in sinonasal polyps and to gain insight into change in expression after oral corticosteroid treatment. STUDY DESIGN AND METHODS: Nasal polyps were obtained before and after oral corticosteroid treatment and Gene expression was analyzed with a focused gene at-ray technique. RESULTS: Pretreated sinonasal polyps demonstrated high gene expression for chemokine and leukotriene receptor genes (CCR2, CCR5, CX3CL1, and LTB4R) in all patients. After treatment, the global effects of corticosteroids were evident on gene expression. CONCLUSIONS: Gene array techniques hold promise as a research method in sinonasal polyposis. The potential benefits, as well as the potential challenges, in using these research methods will be discussed. (C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA. George Washington Univ, Div Otolaryngol, Washington, DC USA. Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. RP Bolger, WE (reprint author), Uniformed Serv Univ Hlth Sci, Div Otolaryngol, 4301 Jones Bridge Rd, Bethesda, MD 20817 USA. EM sinusmd@comcast.net NR 15 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUL PY 2007 VL 137 IS 1 BP 27 EP 33 DI 10.1016/j.otohns.2007.01.023 PG 7 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 185VY UT WOS:000247739700004 PM 17599560 ER PT J AU Pfannenstiel, TJ Gal, TJ Hayes, DK Myers, KV AF Pfannenstiel, Travis J. Gal, Thomas J. Hayes, David K. Myers, Karen V. TI Vocal fold immobility following burn intensive care SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 127th Annual Meeting of the American-Laryngological-Association CY MAY 19-20, 2006 CL Chicago, IL SP Amer Laryngol Assoc ID PROLONGED INTUBATION; LARYNGEAL; INJURY; PARALYSIS AB OBJECTIVE: To evaluate factors associated with the development of vocal fold immobility in patients surviving burn intensive care. STUDY DESIGN AND SETTING: A retrospective review of patients referred to Department of Speech Pathology by the Burn Intensive Care Unit between June 2002 and November 2004. Patients underwent videostroboscopic examination, and associations of vocal fold immobility with factors related to patient management were examined by using logistic regression. RESULTS: Vocal fold immobility was diagnosed in 25 (48%) of the 52 patients evaluated. A significant association with a history of intubation during overseas aeromedical evacuation (odds ratio 4.5, P = 0.026) was observed. Multivariate modeling demonstrated an increased risk of 3% for each % total body surface area (TBSA) of burn. CONCLUSION: High-altitude transport of intubated patients was a significant risk factor in the development of laryngeal injury. SIGNIFICANCE: This study magnifies the role that endotracheal tube cuff pressure may play in recurrent laryngeal nerve injury. (C) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved. C1 Brooke Army Med Ctr, Dept Otolaryngol, Houston, TX USA. Dept Speech Pathol, Houston, TX USA. Wilford Hall USAF Med Ctr, Dept Otolaryngol, Lackland AFB, TX USA. RP Pfannenstiel, TJ (reprint author), Brooke Army Med Ctr, Dept Otolaryngol, 3851 Roger Brooke Dr, Houston, TX 78234 USA. EM travis.pfannenstiel@us.army.mil NR 10 TC 2 Z9 2 U1 0 U2 3 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JUL PY 2007 VL 137 IS 1 BP 152 EP 156 DI 10.1016/j.otohns.2007.03.024 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA 185VY UT WOS:000247739700027 PM 17599583 ER PT J AU May, JW Shmorhun, DP AF May, Joseph W. Shmorhun, Daniel P. TI Migration of an abandoned pacemaker generator into the pouch of Douglas in a child with complex congenital heart disease SO PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY LA English DT Article DE abandoned pacemaker; pacemaker generator; pacemaker migration ID EPICARDIAL PACEMAKER AB A young girl with complex congenital heart disease underwent Fontan procedure and multiple pacemaker revisions, including abandonment of an intraabdominal pacemaker generator at age eight. She presented two years later with constipation and abdominal twitching. Radiographs, pacemaker interrogation, and laparoscopy confirmed dislocation of the abandoned generator and intraperitoneal migration into the pouch of Douglas. The device was removed surgically without incident. C1 Natl Capital Consortium Pediat, Bethesda, MD USA. Natl Capital Consortium Pediat, Washington, DC USA. RP May, JW (reprint author), Walter Reed Army Med Ctr, Dept Pediat Cardiol, 6900 Georgia Ave, Washington, DC 20307 USA. EM Joseph.May@na.amedd.army.mil NR 10 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0147-8389 J9 PACE JI PACE-Pacing Clin. Electrophysiol. PD JUL PY 2007 VL 30 IS 7 BP 910 EP 911 DI 10.1111/j.1540-8159.2007.00780.x PG 2 WC Cardiac & Cardiovascular Systems; Engineering, Biomedical SC Cardiovascular System & Cardiology; Engineering GA 187OE UT WOS:000247856800013 PM 17584274 ER PT J AU Gerhart, G Bankowski, E Melkov, GA Tiberkevich, VS Slavin, AN AF Gerhart, G. Bankowski, E. Melkov, G. A. Tiberkevich, V. S. Slavin, A. N. TI Angular dependence of the microwave-generation threshold in a nanoscale spin-torque oscillator SO PHYSICAL REVIEW B LA English DT Article ID MAGNETIC MULTILAYER; ELECTRIC-CURRENT; EXCITATION; DRIVEN; WAVES AB It is shown that in a spin-torque microwave oscillator based on a magnetic nanocontact, the nature of the microwave spin wave mode generated at the threshold critically depends on the angle between the external bias magnetic field and the plane of the free layer. When the external bias field is rotating from normal to in-plane orientation, an abrupt transition from a propagating cylindrical wave with the frequency higher than the frequency of the linear ferromagnetic resonance (FMR) to a self-localized standing nonlinear spin wave "bullet" with the frequency lower than the FMR frequency takes place at a certain intermediate angle theta(cr). This transition manifests itself as an abrupt jump (of the order of several gigahertz) in the generated microwave frequency. This mechanism of mode switching might explain abrupt jumps of the generated microwave frequency observed in recent experiments on spin-torque oscillators. C1 USA, TARDEC, Warren, MI 48397 USA. Kiev Natl Taras Shevchenko Univ, Radiophys Fac, UA-01033 Kiev, Ukraine. Oakland Univ, Dept Phys, Rochester, MI 48309 USA. RP Gerhart, G (reprint author), USA, TARDEC, Warren, MI 48397 USA. RI Tiberkevich, Vasil/A-8697-2008 OI Tiberkevich, Vasil/0000-0002-8374-2565 NR 18 TC 27 Z9 27 U1 3 U2 11 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL PY 2007 VL 76 IS 2 AR 024437 DI 10.1103/PhysRevB.76.024437 PG 4 WC Physics, Condensed Matter SC Physics GA 196QD UT WOS:000248496200091 ER PT J AU Gowtham, S Scheicher, RH Ahuja, R Pandey, R Karna, SP AF Gowtham, S. Scheicher, Ralph H. Ahuja, Rajeev Pandey, Ravindra Karna, Shashi P. TI Physisorption of nucleobases on graphene: Density-functional calculations SO PHYSICAL REVIEW B LA English DT Article ID WALLED CARBON NANOTUBES; DNA; FLUORESCENCE; MAGNETISM AB We report the results of our first-principles investigation on the interaction of the nucleobases adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U) with graphene, carried out within the density-functional theory framework, with additional calculations utilizing Hartree-Fock plus second-order Moller-Plesset perturbation theory. The calculated binding energy of the nucleobases shows the following hierarchy: G>A approximate to T approximate to C>U, with the equilibrium configuration being rather similar for all five of them. Our results clearly demonstrate that the nucleobases exhibit significantly different interaction strengths when physisorbed on graphene. The stabilizing factor in the interaction between the base molecule and graphene sheet is dominated by the molecular polarizability that allows a weakly attractive dispersion force to be induced between them. The present study represents a significant step toward a first-principles understanding of how the base sequence of DNA can affect its interaction with carbon nanotubes, as observed experimentally. C1 Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. Michigan Technol Univ, Multi Scale Technol Inst, Houghton, MI 49931 USA. Uppsala Univ, Dept Phys, Condensed Matter Theory Grp, S-75121 Uppsala, Sweden. Royal Inst Technol KTH, Dept Mat & Engn, Appl Mat Phys, S-10044 Stockholm, Sweden. USA, Ballist Res Lab, Weapons & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. RP Scheicher, RH (reprint author), Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. RI Pandey, Ravi/A-8759-2009; Scheicher, Ralph/G-1740-2012 NR 26 TC 168 Z9 169 U1 2 U2 51 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD JUL PY 2007 VL 76 IS 3 AR 033401 DI 10.1103/PhysRevB.76.033401 PG 4 WC Physics, Condensed Matter SC Physics GA 196RX UT WOS:000248500800017 ER PT J AU Warrender, JM Aziz, MJ AF Warrender, Jeffrey M. Aziz, Michael J. TI Effect of deposition rate on morphology evolution of metal-on-insulator films grown by pulsed laser deposition SO PHYSICAL REVIEW B LA English DT Article ID COALESCENCE; TEMPERATURE; PERCOLATION; NUCLEATION; DIFFUSION; KINETICS; SILVER; STM; AG AB Ag films were grown by pulsed laser deposition on insulating SiO2 and mica substrates and exhibited a morphological progression beginning with nucleation of three-dimensional islands and culminating in a continuous, electrically conducting film. The rate of advancement through this progression with increasing pulse frequency was studied with experiments and with kinetic Monte Carlo (KMC) simulations. Experiments at 93 and 135 degrees C give exponents of -0.34 and -0.31, respectively, for the scaling of the electrical percolation thickness with pulse frequency. Simulations predicted an exponent of -0.34, in excellent agreement with the experiments. Both of these values agree well with the previously reported analytic value of -0.33 for the scaling of the morphology transition thickness with average flux in continuous deposition. Simulations also predicted that data collapse for island density vs amount deposited would be observed for experiments run at the same value of the parameter B/f at constant amount deposited per pulse, where B is the kinetic rate constant for coalescence and f is the pulse frequency. Measurements of the percolation transition were consistent with this prediction. These findings indicate that the elementary processes included in the KMC simulation-substrate terrace diffusion, irreversible aggregation of hemispherical islands, and two-island coalescence, but neglecting the effects of kinetic energy-are sufficient to explain the behavior observed when the pulse rate is varied at constant kinetic energy. C1 Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA. USA, Benet Labs, Watervliet, NY 12189 USA. RP Warrender, JM (reprint author), Harvard Univ, Sch Engn & Appl Sci, 29 Oxford St, Cambridge, MA 02138 USA. EM jwarrend@post.harvard.edu NR 26 TC 15 Z9 16 U1 2 U2 9 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL PY 2007 VL 76 IS 4 AR 045414 DI 10.1103/PhysRevB.76.045414 PG 8 WC Physics, Condensed Matter SC Physics GA 197FM UT WOS:000248540000108 ER PT J AU Postnikova, E Baldwin, C Whitehouse, CA Sechler, A Schaad, N Sampath, R Harpin, V Li, F Melton, R Blin, L Drader, J Hofstadler, S Schneider, WL AF Postnikova, E. Baldwin, C. Whitehouse, C. A. Sechler, A. Schaad, N. Sampath, R. Harpin, V. Li, F. Melton, R. Blin, L. Drader, J. Hofstadler, S. Schneider, W. L. TI Detection and identification of phytobacteria using PCR/electrospray ionization-mass spectrometry SO PHYTOPATHOLOGY LA English DT Meeting Abstract C1 Ibis Biosci Inc, Carlsbad, CA USA. Foreign Dis Weed Sci Res Unit, Fort Detrick, MD USA. US Army Med Res Inst Infect Dis, Fort Detrick, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER PHYTOPATHOLOGICAL SOC PI ST PAUL PA 3340 PILOT KNOB ROAD, ST PAUL, MN 55121 USA SN 0031-949X J9 PHYTOPATHOLOGY JI Phytopathology PD JUL PY 2007 VL 97 IS 7 SU S BP S94 EP S94 PG 1 WC Plant Sciences SC Plant Sciences GA 181XP UT WOS:000247470000579 ER PT J AU Chung, EM Specht, CS Schroeder, JW AF Chung, Ellen M. Specht, Charles S. Schroeder, Jason W. TI From the archives of the AFIP - Pediatric orbit tumors and tumorlike lesions: Neuroepithelial lesions of the ocular globe and optic nerve SO RADIOGRAPHICS LA English DT Review ID LONG-TERM SURVIVORS; 2ND PRIMARY TUMORS; COATS-DISEASE; FOLLOW-UP; NEUROFIBROMATOSIS TYPE-1; NATURAL-HISTORY; PATHWAY GLIOMAS; TRILATERAL RETINOBLASTOMA; HEREDITARY RETINOBLASTOMA; DIFFERENTIAL-DIAGNOSIS AB Tumors and tumorlike lesions of the globe and optic nerve in children represent a different histologic spectrum than in adults; the imaging appearances of these lesions reflect their pathologic features. Retinoblastoma is a tumor of infancy and the most common intraocular tumor in children. There are heritable and nonheritable forms. The most common clinical finding is leukocoria. The differential diagnoses of this sign include several nonneoplastic lesions: Persistent hyperplastic primary vitreous is a congenital persistence of an embryonic structure causing a retrolental mass. The primitive vasculature may produce a septum in the posterior chamber. Coats disease is a vascular malformation of the retina that produces a lipoproteinaceous subretinal exudate. The vascular malformation enhances with intravenous contrast material, and the fat-containing subretinal exudate does not. Larval endophthalmitis is a granulomatous reaction to the dead or dying larvae of Toxocara canis or T cati. The most important feature that allows differentiation of retinoblastoma from these so-called pseudoretinoblastomas is the presence of calcification in the former. Medulloepithelioma has two histologic forms; the teratoid type may contain calcifications, but it usually arises anteriorly from the ciliary body rather than posteriorly from the retina. Optic nerve glioma is the most common tumor of the optic nerve in children and is frequently associated with neurofibromatosis type 1. These gliomas are usually pilocytic astrocytomas and cause fusiform enlargement of the nerve. C1 Armed Forces Inst Pathol, Dept Radiol Pathol, Washington, DC 20306 USA. Armed Forces Inst Pathol, Ophthalm Pathol Sect, Dept Neuropathol, Washington, DC 20306 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. USN, Natl Med Ctr, Natl Capitol Radiol Consortium, Bethesda, MD 20084 USA. RP Chung, EM (reprint author), Armed Forces Inst Pathol, Dept Radiol Pathol, Alaska & Fern St, Washington, DC 20306 USA. EM chunge@afip.osd.mil NR 119 TC 37 Z9 41 U1 0 U2 3 PU RADIOLOGICAL SOC NORTH AMERICA PI OAK BROOK PA 820 JORIE BLVD, OAK BROOK, IL 60523 USA SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD JUL-AUG PY 2007 VL 27 IS 4 BP 1159 EP U54 DI 10.1148/rg.274075014 PG 29 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 188GZ UT WOS:000247909400018 PM 17620473 ER PT J AU Smith, R AF Smith, Roger TI What CTOs do SO RESEARCH-TECHNOLOGY MANAGEMENT LA English DT Article DE Chief Technology Officer; CTO; innovation; career management AB The Chief Technology Officer position has been adopted by a wide variety of industries that are seeking to leverage technology within products and services. The position calls for an operational executive who can make important strategic decisions that impact the competitive position of the company. However, little research has been done to define the CTO's responsibilities, methods of evaluating the person's performance, and the skills that he or she should bring to the office. This paper identifies five dominant patterns of the CTO position, labeled the Genius, Administrator, Director, Executive, and Advocate. These patterns are useful in understanding the diversity within the position and in matching a CTO from a specific pattern to a business with unique issues to be addressed. C1 USA, Simulat Training & Instrumentat, Orlando, FL USA. RP Smith, R (reprint author), USA, Simulat Training & Instrumentat, Orlando, FL USA. EM rdsmith@modelbenders.com RI Natraj, Shailendra /D-3871-2014; Kumar, Ajit/J-1617-2015 OI Kumar, Ajit/0000-0003-3255-5054 NR 11 TC 3 Z9 3 U1 0 U2 8 PU INDUSTRIAL RESEARCH INSTITUTE, INC PI ARLINGTON PA 2200 CLARENDON BLVD, STE 1102, ARLINGTON, VA 22201 USA SN 0895-6308 J9 RES TECHNOL MANAGE JI Res.-Technol. Manage. PD JUL-AUG PY 2007 VL 50 IS 4 BP 18 EP 22 PG 5 WC Business; Engineering, Industrial; Management SC Business & Economics; Engineering GA 186FA UT WOS:000247763300010 ER PT J AU Jiang, RZ AF Jiang, Rongzhong TI Combinatorial electrochemical cell array for high throughput screening of micro-fuel-cells and metal/air batteries SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID SN-ZN ALLOYS; MASS-SPECTROMETRY; ELECTRODE ARRAYS; WATER OXIDATION; METHANOL; ELECTROCATALYSTS; DISCOVERY; CATALYSTS; CHEMISTRY; PARALLEL AB An electrochemical cell array was designed that contains a common air electrode and 16 microanodes for high throughput screening of both fuel cells (based on polymer electrolyte membrane) and metal/air batteries (based on liquid electrolyte). Electrode materials can easily be coated on the anodes of the electrochemical cell array and screened by switching a graphite probe from one cell to the others. The electrochemical cell array was used to study direct methanol fuel cells (DMFCs), including high throughput screening of electrode catalysts and determination of optimum operating conditions. For screening of DMFCs, there is about 6% relative standard deviation (percentage of standard deviation versus mean value) for discharge current from 10 to 20 mA/cm(2). The electrochemical cell array was also used to study tin/air batteries. The effect of Cu content in the anode electrode on the discharge performance of the tin/air battery was investigated. The relative standard deviations for screening of metal/air battery (based on zinc/air) are 2.4%, 3.6%, and 5.1% for discharge current at 50, 100, and 150 mA/cm(2), respectively. (c) 2007 American Institute of Physics. C1 USA, Res Lab, Sensors & Elect Dev Directorate, Adelphi, MD 20783 USA. RP Jiang, RZ (reprint author), USA, Res Lab, Sensors & Elect Dev Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. NR 39 TC 11 Z9 11 U1 3 U2 23 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUL PY 2007 VL 78 IS 7 AR 072209 DI 10.1063/1.2755439 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA 196MI UT WOS:000248486300010 PM 17672740 ER PT J AU Ulrich, M AF Ulrich, Marybeth TI Dedovshchina in the post-Soviet military: Hazing of Russian army conscripts in a comparative perspective. SO RUSSIAN REVIEW LA English DT Book Review C1 USA, War Coll, Washington, DC USA. RP Ulrich, M (reprint author), USA, War Coll, Washington, DC USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD JUL PY 2007 VL 66 IS 3 BP 541 EP 542 PG 2 WC History SC History GA 179KP UT WOS:000247288700045 ER PT J AU Wu, C Ayers, PD Anderson, AB AF Wu, C. Ayers, P. D. Anderson, A. B. TI GIS and neural network method for potential road identification SO TRANSACTIONS OF THE ASABE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Society-of-Agricultural-and-Biological-Engineers CY 2004 CL Minneapolis, MN DE GIS; neural network; potential road; vehicle tracking ID VEHICLE IMPACTS; FORT-HOOD; DISTURBANCE; VEGETATION; SOILS; PERFORMANCE; PATTERNS; TEXAS; LAND AB Global positioning system (GPS)-based vehicle tracking systems were used to track 20 vehicles involved in an 8-day field training exercise at Yakima Training Center, Washington. A 3-layer feed-forward artificial neural network (NN) with a backpropagation learning algorithm was developed to identify potential roads. The NN was trained using a subset of the GPS data that was supplemented with field observations that documented newly formed road segments resulting from concentrated vehicle traffic during the military training exercise. The NN was subsequently applied to the full vehicle movement data set to predict potential roads for the entire training exercise. Model predictions were validated using additional installation and site visit data. The first validation used the NN to identify the existing road network as represented in the Yakima Training Center GIS roads data layer Next, the NN was used to predict emerging road networks that had not previously existed. The NN method accurately classified approximately 94% of the training data, 85% of the on-road movement data, and 78% of potential roads. The proposed NN method more accurately classified potential roads than the previously used multicriteria method, which was able to identify 10 out of 17 potential road segments across the entire training center. C1 Univ Tennessee, Dept Biosyst Engn & Soil Sci, Knoxville, TN USA. US Army Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL USA. RP Ayers, PD (reprint author), Univ Tennessee, 2506 EJ Chapman Dr, Knoxville, TN 37996 USA. EM pdayers@utk.edu NR 40 TC 0 Z9 2 U1 2 U2 2 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 0001-2351 J9 T ASABE JI Trans. ASABE PD JUL-AUG PY 2007 VL 50 IS 4 BP 1455 EP 1463 PG 9 WC Agricultural Engineering SC Agriculture GA 210OR UT WOS:000249466000034 ER PT J AU Thorp, KR Batchelor, WD Paz, JO Kaleita, AL DeJonge, KC AF Thorp, K. R. Batchelor, W. D. Paz, J. O. Kaleita, A. L. DeJonge, K. C. TI Using cross-validation to evaluate CERES-Maize yield simulations within a decision support system for precision agriculture SO TRANSACTIONS OF THE ASABE LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Society-of-Agricultural-and-Biological-Engineers CY NOV 09-12, 2005 CL Univ Wisconsin-Madison, Madison, WI HO Univ Wisconsin-Madison DE corn; crop model; cross-validation; decision support system; precision agriculture; spatial variability; yield ID NITROGEN MANAGEMENT; MEASURED VALUES; SOYBEAN YIELD; MODEL; WATER; CORN; VARIABILITY; GROWTH; STRATEGIES; DRAINAGE AB Crop growth models have recently been implemented to study precision agriculture questions within. the framework of a decision support system (DSS) that automates simulations across management zones. Model calibration in each zone has occurred by automatically optimizing select model parameters to minimize error between measured and simulated yield over multiple growing seasons. However, to date, there have been no efforts to evaluate model simulations within the DSS. In this work, a model evaluation procedure based on leave-one-out cross-validation was developed to explore several issues associated with the implementation of CERES-Maize within the DSS. Five growing seasons of measured yield data from a central Iowa cornfield were available for cross-validation. Two strategies were used to divide the study area into management zones, one based on soil type and the other based on topography. The decision support system was then used to carry out the model calibration and validation simulations as required to complete the cross-validation procedure. Results demonstrated that the model's ability to simulate corn yield improved as more growing seasons were used in the cross-validation. For management zones based on topography, the average root mean squared error of prediction (RMSEP) from cross-validations was 1460 kg ha(-1) when two growing seasons were used and 998 kg ha-1 when five years were used. Model performance was shown to vary spatially based on soil type and topography. Average RMSEP was 1651 kg ha-1 on zones of Nicollet loam, while it was 496 kg ha-1 on zones of Canisteo silty clay loam. Spatial patterns also existed between areas of higher RMSEP and areas where measured spatial yield variability was related to topography. Changes in the mean and variance of optimum parameter sets as more growing seasons were used in cross-validation demonstrated that the optimizer was able to arrive at more stable solutions in some zones as compared to others. Results suggested that cross-validation was an appropriate method for addressing several issues associated with the use of crop growth models within a DSS for precision agriculture. C1 USDA ARS, Arid Land Agr Res Ctr, Maricopa, AZ USA. Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA. Univ Georgia, Dept Agr & Biol Engn, Griffin, GA USA. Iowa State Univ, Dept Agr & Biosyst Engn, Ames, IA USA. US Army Corps Engn, Omaha, NE USA. RP Thorp, KR (reprint author), USDA ARS, ALARC 182, 21881 N Cardon Ln, Maricopa, AZ USA. EM kthorp@uswcl.ars.ag.gov RI Paz, Joel/F-7685-2010; Thorp, Kelly/C-2013-2009; Basso, Bruno/A-3128-2012; Kaleita, Amy/J-8363-2016; OI Thorp, Kelly/0000-0001-9168-875X; Basso, Bruno/0000-0003-2090-4616; Kaleita, Amy/0000-0002-8906-3408; Paz, Joel/0000-0003-0193-3681 NR 47 TC 11 Z9 12 U1 0 U2 13 PU AMER SOC AGRICULTURAL & BIOLOGICAL ENGINEERS PI ST JOSEPH PA 2950 NILES RD, ST JOSEPH, MI 49085-9659 USA SN 0001-2351 J9 T ASABE JI Trans. ASABE PD JUL-AUG PY 2007 VL 50 IS 4 BP 1467 EP 1479 PG 13 WC Agricultural Engineering SC Agriculture GA 210OR UT WOS:000249466000035 ER PT J AU Heppner, DG Schwenk, RJ Arnot, D Sauerwein, RW Luty, AJF AF Heppner, D. Gray Schwenk, Robert J. Arnot, David Sauerwein, Robert W. Luty, Adrian J. F. TI The dog that did not bark: malaria vaccines without antibodies SO TRENDS IN PARASITOLOGY LA English DT Article ID PRIME-BOOST IMMUNIZATION; CIRCUMSPOROZOITE PROTEIN VACCINE; PLASMODIUM-FALCIPARUM MALARIA; FOWLPOX STRAIN FP9; VIRUS ANKARA; VIRAL VECTORS; ME-TRAP; SPOROZOITE VACCINE; RANDOMIZED-TRIAL; MVA-CS AB To date, the only pre-blood stage vaccine to confer protection against malaria in field trials elicits both antigen-specific antibody and T-cell responses. Recent clinical trials of new heterologous prime-boost malaria vaccine regimens using DNA, fowlpox or MVA, have chiefly elicited T-cell responses that have promisingly reduced hepatic merozoites in challenge trials, but failed to protect in field trials. These encouraging results suggest further augmentation of T-cell responses to pre-blood stage antigens might one day contribute to a highly protective vaccine. We envision that a highly protective pre-erythrocytic vaccine will likely be based upon a heterologous prime-boost regimen that induces both appropriate T-cell responses as well as robust and protracted antibody production. C1 Radboud Univ Nijmegen, Ctr Med, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Univ Copenhagen, Panum Inst, Ctr Med Parasitol, Inst Med Microbiol & Immunol, DK-2200 Copenhagen, Denmark. RP Luty, AJF (reprint author), Radboud Univ Nijmegen, Ctr Med, Dept Med Microbiol, MMB-NCMLS,POB 9101, NL-6500 HB Nijmegen, Netherlands. EM a.luty@mmb.umcn.nl RI Sauerwein, Robert/C-8519-2013 NR 31 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD JUL PY 2007 VL 23 IS 7 BP 293 EP 296 DI 10.1016/j.pt.2007.05.002 PG 4 WC Parasitology SC Parasitology GA 189BI UT WOS:000247963000001 PM 17512252 ER PT J AU Kubata, BK Duszenko, M Martin, S Urade, Y AF Kubata, Bruno Kilunga Duszenko, Michael Martin, Samuel Urade, Yoshihiro TI Molecular basis for prostaglandin production in hosts and parasites SO TRENDS IN PARASITOLOGY LA English DT Review ID GLUTATHIONE-S-TRANSFERASE; TRYPANOSOMA-CRUZI INFECTION; LIVER-ABSCESS FORMATION; PROGRAMMED CELL-DEATH; BRUCEI BLOOD-STREAM; OLD YELLOW ENZYME; ENTAMOEBA-HISTOLYTICA; SCHISTOSOMA-MANSONI; MURINE LEISHMANIASIS; CRYSTAL-STRUCTURE AB Prostaglandins (PGs) comprise a family of structurally related bioactive lipid mediators that are involved in various symptoms associated with parasitic diseases. The molecular mechanisms of PG biosynthesis in animals have been studied extensively. Currently, several lines of evidence link their production with parasites. In this review we discuss the roles of PGs in parasite pathogenesis and physiology and the recent advances in our understanding of the enzymology of PG production in various parasites. C1 Biosci Eastern & Cent Africa, NEPAD Ctr Excellence, Nairobi 00100, Kenya. Univ Tubingen, Physiol Chem Inst, D-72076 Tubingen, Germany. USA, Med Res Unit Kenya, Unit 64109, APO, AE 09831 USA. Osaka Biosci Inst, Dept Mol Behav Biol, Suita, Osaka 5650874, Japan. RP Kubata, BK (reprint author), Biosci Eastern & Cent Africa, NEPAD Ctr Excellence, POB 30709, Nairobi 00100, Kenya. EM b.kubata@africabiosciences.org NR 60 TC 25 Z9 26 U1 1 U2 13 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1471-4922 J9 TRENDS PARASITOL JI Trends Parasitol. PD JUL PY 2007 VL 23 IS 7 BP 325 EP 331 DI 10.1016/j.pt.2007.05.005 PG 7 WC Parasitology SC Parasitology GA 189BI UT WOS:000247963000010 PM 17531535 ER PT J AU Vanasupa, BP Aaberg, RA Sutherland, RS AF Vanasupa, Bill P. Aaberg, Randal A. Sutherland, Ronald S. TI Testicular teratoma with Nephroblastoma component SO UROLOGY LA English DT Article ID WILMS-TUMOR; TESTIS; WT1; CELLS AB We report the development of Wilms' tumor in an atrophic testis and review the potential molecular pathogenesis. An 18-year-old man presented with 2 days of right testicular pain and growth in his atrophic testis. Ultrasonography revealed a heterogeneous mass. The chest radiographic findings and testicular tumor marker levels were normal. He underwent radical orchiectomy, with the pathologic examination showing teratoma with a nephroblastoma component, focal embryonal carcinoma, and minute yolk sac tumor. The development of Wilms' tumor in the testis is rare and can be explained by the activation of the WT1 gene during embryogenesis. C1 Tripler Army Med Ctr, Dept Surg, Urol Serv, Honolulu, HI 96859 USA. Moanalua Med Ctr, Kaiser Permanente, Dept Surg, Urol Serv, Honolulu, HI USA. RP Vanasupa, BP (reprint author), Tripler Army Med Ctr, Dept Surg, Urol Serv, 1 Jarret White Rd, Honolulu, HI 96859 USA. EM pitapong@yahoo.com NR 9 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD JUL PY 2007 VL 70 IS 1 AR 179.el DI 10.1016/j.urology.2007.03.067 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA 209LT UT WOS:000249390700054 ER PT J AU Jameson, MJ Robards, TA AF Jameson, Marc J. Robards, Timothy A. TI Coast redwood regeneration survival and growth in Mendocino county, California SO WESTERN JOURNAL OF APPLIED FORESTRY LA English DT Article DE seedling; sprout; broadcast burn; vegetation control; Sequoia sempervirens AB Three stands of second-growth redwood forest were clearcut, and the logging slash in two of the units was broadcast burned following logging. Three types of redwood seedlings (plug, plug-one, and 2-year bareroot) were planted following logging and burning. Seedling survival rates were high, and there were no significant differences between survival and growth of stock types after 9 years. The native redwood sprouts were substantially larger than the planted seedlings, in both height and diameter, which could affect future growth of some seedlings. The status and dimensions of seedlings and native regeneration were periodically checked. The burned units were fully occupied by a dense, tall growth of brush within a few years, and the brush became re-established after a successful initial herbicide treatment. C1 Calif Dept Forestry & Fire Protect, Ft Bragg, CA 95437 USA. Calif Dept Forestry & Fire Protect, Sacramento, CA 94244 USA. RP Jameson, MJ (reprint author), Calif Dept Forestry & Fire Protect, Ft Bragg, CA 95437 USA. EM marc.jameson@fire.ca.gov NR 8 TC 4 Z9 4 U1 2 U2 9 PU SOC AMER FORESTERS PI BETHESDA PA 5400 GROSVENOR LANE, BETHESDA, MD 20814 USA SN 0885-6095 J9 WEST J APPL FOR JI West. J. Appl. For. PD JUL PY 2007 VL 22 IS 3 BP 171 EP 175 PG 5 WC Forestry SC Forestry GA 190ZC UT WOS:000248098400004 ER PT J AU Li, S Shah, A Hsieh, AJ Haghighat, R Praveen, SS Mukherjee, I Wei, E Zhang, Z Wei, Y AF Li, Shuxi Shah, Apoorva Hsieh, Alex J. Haghighat, Ross Praveen, S. Solomon Mukherjee, Indraneil Wei, Elizabeth Zhang, Zongtao Wei, Yen TI Characterization of poly(2-hydroxyethyl methacrylate-silica) hybrid materials with different silica contents SO POLYMER LA English DT Article DE Poly(HEMA-silica) hybrid materials; sol-gel synthesis; nanoindentation ID SOL-GEL MATERIALS; MECHANICAL-PROPERTIES; THIN-FILMS; NANOCOMPOSITES; TETRAETHOXYSILANE; COMPOSITES; POLYMERS AB Poly(2-hydroxyethyl methacrylate-silica) hybrid materials with significantly lower volume shrinkage were synthesized by using acid-catalyzed sot-gel reactions of tetraethyl orthosilicate and free radical polymerization of 2-hydroxyethyl methacrylate (HEMA). The mechanical, thermal, and optical properties and internal porosities of the poly(HEMA-silica) hybrids with different silica contents (e.g., 15, 25 and 30 wt%) were evaluated with the use of nanoindentation, microscratch, thermogravimetric analysis, differential scanning calorimetry, dynamic mechanical analysis, UVvis spectrophotometer and N-2 adsorption -desorption method. A silica percolation threshold was found at around 20-25 wt%, beyond which a marked increase in the poly(HEMA-silica) hybrid hardness and modulus was observed as compared to pure poly(HEMA). Nanoindentation and scratch testing measurements also for the first time were introduced in characterizing poly(HEMA-silica) hybrid materials. (c) 2007 Elsevier Ltd. All rights reserved. C1 Drexel Univ, Ctr Adv Polymer & Mat Chem, Dept Chem, Philadelphia, PA 19104 USA. Triton Syst Inc, Chelmsford, MA 01824 USA. AMSRD ARL WM MD, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. Jilin Univ, Dept Chem, Changchun 130023, Peoples R China. RP Wei, Y (reprint author), Drexel Univ, Ctr Adv Polymer & Mat Chem, Dept Chem, 3141 Chestnut St, Philadelphia, PA 19104 USA. EM weiyen@drexel.edu RI Wei, Yen/H-5329-2012 NR 37 TC 27 Z9 28 U1 1 U2 9 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD JUN 29 PY 2007 VL 48 IS 14 BP 3982 EP 3989 DI 10.1016/j.polymer.2007.05.025 PG 8 WC Polymer Science SC Polymer Science GA 187NQ UT WOS:000247855300009 ER PT J AU Hicks, RP Bhonsle, JB Venugopal, D Koser, BW Magill, AJ AF Hicks, Rickey P. Bhonsle, Jayendra B. Venugopal, Divakaramenon Koser, Brandon W. Magill, Alan J. TI De novo design of selective antibiotic peptides by incorporation of unnatural amino acids SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID HELICAL ANTIMICROBIAL PEPTIDES; ANTIBACTERIAL ACTIVITY; PHOSPHOLIPID-MEMBRANES; POLYCATIONIC PEPTIDES; BIOLOGICAL-ACTIVITY; NMR INVESTIGATIONS; LYTIC PEPTIDES; MODEL PEPTIDES; PORE FORMATION; SDS MICELLES AB The evolution of drug-resistant bacteria is one of the most critical problems facing modern medicine and requires the development of new drugs that exhibit their antibacterial activity via novel mechanisms of action. One potential source of new drugs could be the naturally occurring peptides that exhibit antimicrobial activity via membrane disruption. To develop antimicrobial peptides exhibiting increased potency and selectivity against Gram positive, Gram negative, and Mycobacterium bacteria coupled with reduced hemolytic activity, peptides containing unnatural amino acids have been designed, synthesized, and evaluated. These compounds were designed on the basis of the electrostatic surface potential maps derived from the NMR determined SDS and DPC micelle-bound conformations of (Ala(8,13,18))magainin-2 amide. Unnatural amino acids were incorporated into the polypeptide backbone to control the structural and physicochemical properties of the peptides to introduce organism selectivity and potency. The methods and results of this investigation are described below. C1 Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Hicks, RP (reprint author), E Carolina Univ, Dept Chem, Sci & Technol Bldg,Suite 300, Greenville, NC 27858 USA. EM hicksr@ecu.edu RI Bhonsle, Jayendra/A-9139-2011 NR 70 TC 41 Z9 43 U1 3 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUN 28 PY 2007 VL 50 IS 13 BP 3026 EP 3036 DI 10.1021/jm061489v PG 11 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 180VO UT WOS:000247394600009 PM 17547385 ER PT J AU Kinyanjui, SM Conway, DJ Lanar, DE Marsh, K AF Kinyanjui, Samson M. Conway, David J. Lanar, David E. Marsh, Kevin TI IgG antibody responses to Plasmodium falciparum merozoite antigens in Kenyan children have a short half-life SO MALARIA JOURNAL LA English DT Article ID LIVED PLASMA-CELLS; RHOPTRY-ASSOCIATED PROTEIN-1; HIGHLY ENDEMIC AREA; PAPUA-NEW-GUINEA; MEMORY B-CELLS; SURFACE PROTEIN-1; HUMORAL IMMUNITY; UNSTABLE MALARIA; VACCINATION; TRANSMISSION AB Background: Data suggest that antibody responses to malaria parasites merozoite antigens are generally short-lived and this has implications for serological studies and malaria vaccine designs. However, precise data on the kinetics of these responses is lacking. Methods: IgG1 and IgG3 responses to five recombinant Plasmodium falciparum merozoite antigens (MSP-119, MSP-2 type A and B, AMA-1 ectodomain and EBA-175 region II) among Kenyan children were monitored using ELISA for 12 weeks after an acute episode of malaria and their half-lives estimated using an exponential decay model. Results: The responses peaked mainly at week 1 and then decayed rapidly to very low levels within 6 weeks. Estimation of the half-lives of 40 IgG1 responses yielded a mean half-life of 9.8 days (95% CI: 7.6-12.0) while for 16 IgG3 responses it was 6.1 days (95% CI: 3.7-8.4), periods that are shorter than those normally described for the catabolic half-life of these antibody subclasses. Conclusion: This study indicates antibodies against merozoite antigens have very short half-lives and this has to be taken into account when designing serological studies and vaccines based on the antigens. C1 Kenya Govt Med Res Ctr, Ctr Geograph Med Res Coast, Kilifi, Kenya. Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England. MRC Labs, Banjul, Senegal. Walter Reed Army Inst Res, Dept Immunol, Silver Spring, MD 20910 USA. RP Kinyanjui, SM (reprint author), Kenya Govt Med Res Ctr, Ctr Geograph Med Res Coast, POB 230, Kilifi, Kenya. EM skmuchina@kilifi.kemri-wellcome.org; dconway@mrc.gm; david.lanar@na.amedd.army.mil; kmarsh@kilifi.kemri-wellcome.org RI Lanar, David/B-3560-2011; OI Conway, David/0000-0002-8711-3037 FU Medical Research Council [MC_U190074193]; Wellcome Trust [631342] NR 33 TC 86 Z9 88 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 28 PY 2007 VL 6 AR 82 DI 10.1186/1475-2875-6-82 PG 8 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 191WH UT WOS:000248162200001 PM 17598897 ER PT J AU Mather, BD Baker, MB Beyer, FL Green, MD Berg, MAG Long, TE AF Mather, Brian D. Baker, Margaux B. Beyer, Frederick L. Green, Matthew D. Berg, Michael A. G. Long, Timothy E. TI Multiple hydrogen bonding for the noncovalent attachment of ionic functionality in triblock copolymers SO MACROMOLECULES LA English DT Article ID BLOCK-COPOLYMERS; RADICAL POLYMERIZATION; SIDE-CHAIN; IONOMERS; POLYMERS; MONOMERS; MACROMOLECULES; NITROXIDE C1 Virginia Tech, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. USA, Res Lab, Div Mat, Aberdeen Proving Ground, MD 21005 USA. RP Long, TE (reprint author), Virginia Tech, Dept Chem, Macromol & Interfaces Inst, Blacksburg, VA 24061 USA. EM telong@vt.edu NR 32 TC 25 Z9 25 U1 1 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JUN 26 PY 2007 VL 40 IS 13 BP 4396 EP 4398 DI 10.1021/ma070102a PG 3 WC Polymer Science SC Polymer Science GA 180DK UT WOS:000247340700003 ER PT J AU Bansal, NP Zhu, DM AF Bansal, Narottam P. Zhu, Dongming TI Effects of doping on thermal conductivity of pyrochlore oxides for advanced thermal barrier coatings SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article DE pyrochlore oxides; thermal conductivity; thermal barrier coatings; doping ID LANTHANUM; SYSTEM; TBCS AB Pyrochlore oxides of general composition, A(2)B(2)O(7), where A is a 3+ cation (La to Lu) and B is a 4+ cation (Zr, Hf, Ti, etc.) have high melting point, relatively high coefficient of thermal expansion, and low thermal conductivity which make them suitable for applications as high-temperature thermal barrier coatings. The effect of doping at the A site on the thermal conductivity of a pyrochlore oxide La2Zr2O7, has been investigated. Oxide powders of various compositions La2Zr2O7, La1.7Gd0.3Zr2O7, La1.7Yb0.3Zr2O7 and La1.7Gd0.15Yb0.15Zr2O7 were synthesized by the citric acid sol-gel method. These powders were hot-pressed into discs and used for thermal conductivity measurements using a steady-state laser heat flux test technique. The rare-earth oxide doped pyrochlores La1.7Gd0.3Zr2O7, La1.7Yb0.3Zr2O7 and La1.7Gd0.15Yb0.15Zr,07 had lower thermal conductivity than the undoped La2Zr2O7. The Gd2O3 and Yb-0.3 co-doped composition showed the lowest thermal conductivity. (C) 2007 Elsevier B.V. All rights reserved. C1 NASA, Glenn Res Ctr, Mat & Struct Div, Cleveland, OH 44135 USA. USA, Res Lab, NASA, Glenn Res Ctr,Vehicle Technol Directorate, Cleveland, OH 44135 USA. RP Bansal, NP (reprint author), NASA, Glenn Res Ctr, Mat & Struct Div, Cleveland, OH 44135 USA. EM Narottam.P.Bansal@nasa.gov NR 12 TC 55 Z9 65 U1 6 U2 63 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD JUN 25 PY 2007 VL 459 IS 1-2 BP 192 EP 195 DI 10.1016/j.msea.2007.01.069 PG 4 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA 171IL UT WOS:000246729300026 ER PT J AU Alexander, TA Le, DM AF Alexander, Troy A. Le, Dianna M. TI Characterization of a commercialized SERS-active substrate and its application to the identification of intact Bacillus endospores SO APPLIED OPTICS LA English DT Article ID ENHANCED-RAMAN-SCATTERING; SINGLE-MOLECULE; BIOLOGICAL WEAPON; BACTERIAL-SPORES; SPECTROSCOPY; ANTHRACIS; ARRAYS; BIOTERRORISM; SPECTROMETER; NANOPARTICLE AB Surface-enhanced-Raman-spectroseopy (SERS) can be made an attractive approach for the identification of Raman-active compounds and biological materials (i.e., toxins, viruses, or intact bacterial cells or spores) through development of reproducible, spatially uniform SERS-active substrates. Recently, reproducible (from substrate to substrate), spatially homogeneous (over large areas) SERS-active substrates have been commercialized and are now available in the marketplace. Scanning electron microscopy and high-resolution, tapping-mode atomic force microscopy have been used to analyze these novel plasmonic surfaces for topographical consistency. Additionally, we have assessed, by wavelength-tunable microreflectance spectrometry, the spatial distribution of the localized surface plasmon resonance (LSPR) across a single substrate surface as well as the LSPR lambda(MAX) variance from substrate to substrate. These analyses reveal that these surfaces are topologically uniform with small LSPR variance from substrate to substrate. Further, we have utilized these patterned surfaces to acquire SERS spectral signatures of four intact, genetically distinct Bacillus spore species cultivated under identical growth conditions. Salient spectral signature features make it possible to discriminate among these genetically distinct spores. Additionally, partial least squares, a multivariate calibration method, has been used to develop personal-computer-borne algorithms useful for classification of unknown spore samples based solely on SERS spectral signatures. To our knowledge, this is the first report detailing application of these commercially available SERS-active substrates to identification of intact Bacillus spores. (c) 2007 Optical Society of America. C1 USA, Opt Branch Biol Inspired Devices Sensors Team, Sensors & Elect Devices Directorate, Res Lab,AMSRD ARL SE EO, Adelphi, MD 20783 USA. US Mil Acad, Dept Geog & Environm Engn, West Point, NY 10996 USA. RP Alexander, TA (reprint author), USA, Opt Branch Biol Inspired Devices Sensors Team, Sensors & Elect Devices Directorate, Res Lab,AMSRD ARL SE EO, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM talexander@arl.army.mil NR 57 TC 39 Z9 40 U1 2 U2 18 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD JUN 20 PY 2007 VL 46 IS 18 BP 3878 EP 3890 DI 10.1364/AO.46.003878 PG 13 WC Optics SC Optics GA 178YQ UT WOS:000247256700028 PM 17538686 ER PT J AU Ahn, WY Sheeley, SA Rajh, T Cropek, DM AF Ahn, Won-Young Sheeley, Sarah A. Rajh, Tijana Cropek, Donald M. TI Photocatalytic reduction of 4-nitrophenol with arginine-modified titanium dioxide nanoparticles SO APPLIED CATALYSIS B-ENVIRONMENTAL LA English DT Article DE photocatalysis; nitrophenol; surface-modified titanium dioxide ID SURFACE MODIFICATION; PHOTOCHEMICAL REDUCTION; ORGANIC POLLUTANTS; IRRADIATED TIO2; VISIBLE-LIGHT; DEGRADATION; WATER; KINETICS; OXIDATION; REMOVAL AB The surface charge of titanium dioxide (TiO2) affects the adsorption rates of target molecules, thereby influencing the associated photocatalytic dearadation rates of these molecules. This study describes the specific photocatalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) with arginine-modified TiO2 (Arg-TiO2) nanoparticles. 4-AP was the only identifiable by-product detected by chromatographic analysis. The terminal amine groups of the arginine monolayer create a positive TiO2 surface charge over a wide range of pH values. At high pH, the degradation rate of 4-NP increased due to improved target adsorption. Furthermore, the presence of the arginine monolayer perturbs the degradation mechanism distribution of 4-NP away front indiscriminant oxidation toward selective reduction. Photocatalysis of a target molecule such as benzenesulfonic acid (BSA) showed that while electrostatic attraction of the target to the photocatalyst is important, the reduction potential of the target molecule dictates efficient degradation on Arg-TiO2. (c) 2007 Elsevier B.V. All rights reserved. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA. Argonne Natl Lab, Div Chem, Argonne, IL 60439 USA. RP Cropek, DM (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61822 USA. EM Donald.M.Cropek@erdc.usace.army.mil NR 34 TC 49 Z9 53 U1 5 U2 36 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0926-3373 J9 APPL CATAL B-ENVIRON JI Appl. Catal. B-Environ. PD JUN 18 PY 2007 VL 74 IS 1-2 BP 103 EP 110 DI 10.1016/j.apcatb.2007.01.016 PG 8 WC Chemistry, Physical; Engineering, Environmental; Engineering, Chemical SC Chemistry; Engineering GA 185OK UT WOS:000247720100012 ER PT J AU Mahros, AM Luen, MO Emara, A Bedair, SM Berkman, EA El-Masry, NA Zavada, JM AF Mahros, Amr M. Luen, M. O. Emara, A. Bedair, S. M. Berkman, E. A. El-Masry, N. A. Zavada, J. M. TI Magnetic and magnetotransport properties of (AlGaN/GaN): Mg/(GaMnN) heterostructures at room temperature SO APPLIED PHYSICS LETTERS LA English DT Article ID FERROMAGNETIC PROPERTIES; SEMICONDUCTORS; ACCEPTOR; MN AB Dilute magnetic semiconductor films (GaMnN) are highly resistive, making transport measurements difficult to achieve. However, when GaMnN films are sandwiched between p-type doped (AlGaN/GaN) strained- layer superlattices, holes from the superlattice interact with the Mn3+/2+ ions and transport measurements were realized. The authors have found also that the ferromagnetic properties of GaMnN critically depend on the level of p-type doping in the superlattice. They report anomalous Hall effect measurements in this (AlGaN/Ga):Mg/(GaMnN) multilayered structure. The current results also demonstrate the role of carriers, especially holes, in mediating the ferromagnetic properties of GaMnN dilute magnetic semiconductor films. (c) 2007 American Institute of Physics. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. N Carolina State Univ, Mat Sci & Engn Dept, Raleigh, NC 27695 USA. Army Res Off, Durham, NC 27709 USA. RP Mahros, AM (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM elmasry@ncsu.edu RI Mahros, Amr/A-1005-2013 OI Mahros, Amr/0000-0002-2621-9479 NR 14 TC 9 Z9 9 U1 2 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 18 PY 2007 VL 90 IS 25 AR 252503 DI 10.1063/1.2749717 PG 3 WC Physics, Applied SC Physics GA 181XE UT WOS:000247468900051 ER PT J AU Scott, P Deye, G Srinivasan, A Murray, C Moran, K Hulten, E Fishbain, J Craft, D Riddell, S Lindler, L Mancuso, J Milstrey, E Bautista, CT Patel, J Ewell, A Hamilton, T Gaddy, C Tenney, M Christopher, G Petersen, K Endy, T Petruccelli, B AF Scott, Paul Deye, Gregory Srinivasan, Arjun Murray, Clinton Moran, Kimberly Hulten, Ed Fishbain, Joel Craft, David Riddell, Scott Lindler, Luther Mancuso, James Milstrey, Eric Bautista, Christian T. Patel, Jean Ewell, Alessa Hamilton, Tacita Gaddy, Charla Tenney, Martin Christopher, George Petersen, Kyle Endy, Timothy Petruccelli, Bruno TI An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID EXPERIENCE; FREEDOM; CONTAMINATION; INJURY; UNIT AB Background. We investigated an outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection among US service members injured in Iraq. Methods. The investigation was conducted in Iraq and Kuwait, in the 2 military hospitals where the majority of injured service members were initially treated. After initially characterizing the outbreak, we evaluated 3 potential sources of infection for the period March 2003 to December 2004. The evaluation included screening samples that were obtained from the skin of patients for the presence of colonization and assessing the soil and health care environments for the presence of A. baumanii-calcoaceticus complex organisms. Isolates obtained from samples from patients in US Military treatment facilities, as well as environmental isolates, were genotypically characterized and compared using pulsed-field gel electrophoresis. Results. A. baumanii-calcoaceticus complex organisms were present on the skin in only 1 (0.6%) of 160 patients who were screened and in 1 (2%) of 49 soil samples. A. baumanii-calcoaceticus complex isolates were recovered from treatment areas in 7 of the 7 field hospitals sampled. Using pulsed-field gel electrophoresis, we identified 5 cluster groups in which isolates from patients were related to environmental isolates. One cluster included hospitalized patients who had not been deployed to Iraq. Among the clinical isolates, only imipenem, polymyxin B, and colistin demonstrated reliable in vitro antimicrobial activity. Generally, the environmental isolates were more drug susceptible than were the clinical isolates. Conclusions. Our findings suggest that environmental contamination of field hospitals and infection transmission within health care facilities played a major role in this outbreak. On the basis of these findings, maintaining infection control throughout the military health care system is essential. Novel strategies may be required to prevent the transmission of pathogens in combat field hospitals. C1 Walter Reed Army Med Ctr, Div Retrovirol, Rockville, MD 20850 USA. Natl Naval Med Ctr, Bethesda, MD USA. USA, Ctr Hlth Promot & Prevent Med, Aberdeen, MD USA. Ctr Dis Control & Prevent, Atlanta, GA USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Landstuhl Reg Med Ctr, Landstuhl, Germany. USA, Ctr Hlth Promot & Prevent Med Europe, Landstuhl, Germany. 28th Combat Support Hosp, Baghdad, Iraq. RP Scott, P (reprint author), Walter Reed Army Med Ctr, Div Retrovirol, 1 Taft Ct,Ste 250, Rockville, MD 20850 USA. EM pscott@hivresearch.org RI Bautista, Christian/B-2812-2011; OI Hulten, Edward/0000-0001-9281-0032 NR 26 TC 191 Z9 199 U1 5 U2 11 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN 15 PY 2007 VL 44 IS 12 BP 1577 EP 1584 DI 10.1086/518170 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 170JA UT WOS:000246658200009 PM 17516401 ER PT J AU Kopchick, JG Storey, RF Beyer, FL Mauritz, KA AF Kopchick, James G. Storey, Robson F. Beyer, Frederick L. Mauritz, Kenneth A. TI Poly[acrylic acid-b-styrene-b-i sobutylene-b-styrene-b-acrylic acid] pentablock terpolymers: 1. Morphological characterization SO POLYMER LA English DT Article DE pentablock terpolymer; styrene; morphology ID TRANSFER RADICAL POLYMERIZATION; ABC TRIBLOCK COPOLYMERS; TERT-BUTYL ACRYLATE; BLOCK-COPOLYMERS; METHYL-METHACRYLATE; ALIGNMENT; SHEAR AB The morphologies of synthesized poly[acrylic acid-b-styrene-b-isobutylene-b-styrene-b-acrytic acid] pentablock terpolymers were investigated using transmission electron microscopy, atomic force microscopy, small angle X-ray scattering, and indirectly by dynamic mechanical analysis and degree of water sorption. These materials possess considerable order within three-phase morphologies that contain the usual elements of rods and lamellae that are arranged as a function of polyacrylic acid block composition in continuous polyisobutylene phases. (C) 2007 Elsevier Ltd. All rights reserved. C1 Univ So Mississippi, Dept Polymer Sci, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA. USA, Res Lab, Weap & Mat Res Directorate, Multifunct Mat Branch, Aberdeen Proving Ground, MD 21005 USA. RP Mauritz, KA (reprint author), Univ So Mississippi, Dept Polymer Sci, Sch Polymers & High Performance Mat, SS Box 10076, Hattiesburg, MS 39406 USA. EM kenneth.inauritz@usm.edu NR 16 TC 7 Z9 7 U1 0 U2 7 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD JUN 15 PY 2007 VL 48 IS 13 BP 3739 EP 3748 DI 10.1016/j.polymer.2007.04.048 PG 10 WC Polymer Science SC Polymer Science GA 201OU UT WOS:000248842600018 ER PT J AU Stricker, JT Gudmundsdottir, AD Smith, AP Taylor, BE Durstock, MF AF Stricker, Jeffery T. Gudmundsdottir, Anna D. Smith, Adam P. Taylor, Barney E. Durstock, Michael F. TI Fabrication of organic thin-film transistors using layer-by-layer assembly SO JOURNAL OF PHYSICAL CHEMISTRY B LA English DT Article ID SEQUENTIALLY ADSORBED LAYERS; FIELD-EFFECT TRANSISTORS; POLYELECTROLYTE MULTILAYERS; CONDUCTING POLYMERS; ELECTRIC-FIELD; CHEMICAL DERIVATIZATION; EFFECT DEVICES; PH; TRANSPORT; REDOX AB Layer-by-layer assembly is presented as a deposition technique for the incorporation of ultrathin gate dielectric layers into thin-film transistors utilizing a highly doped organic active layer. This deposition technique enables the fabrication of device structures with a controllable gate dielectric thickness. In particular, devices with a dielectric layer comprised of poly(allylamine hydrochloride)/poly(acrylic acid) (PAH/PAA) bilayer films were fabricated to examine the properties of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) as the transistor active layer. The transistor I-on/off ratio and switching speed are shown to be controlled by the gate bias, which is dependent upon the voltage applied and the number of bilayers deposited for the gate dielectric. The devices operate in the depletion mode as a result of dedoping of the active layer with the application of a positive gate bias. The depletion and recovery rate are highly dependent on the level of hydration in the film and the environment under which the device is operated. These observations are consistent with an electrochemical dedoping of the conducting polymer during operation. C1 USA, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA. UES Inc, Beavercreek, OH USA. Univ Dayton, Res Inst, Dayton, OH 45469 USA. RP Durstock, MF (reprint author), USA, Res Lab, Mat & Mfg Directorate, Wright Patterson AFB, OH 45433 USA. EM Michael.Durstock@wpafb.af.mil NR 40 TC 16 Z9 18 U1 2 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1520-6106 J9 J PHYS CHEM B JI J. Phys. Chem. B PD JUN 14 PY 2007 VL 111 IS 23 BP 6322 EP 6326 DI 10.1021/jp0688862 PG 5 WC Chemistry, Physical SC Chemistry GA 175SK UT WOS:000247034100005 PM 17511494 ER PT J AU Kim, SC Kim, DW Lee, J Wang, YP Yang, K Kumar, J Bruno, FF Samuelson, LA AF Kim, Seong-Cheol Kim, Dongwook Lee, Joonsuk Wang, Yanping Yang, Ke Kumar, Jayant Bruno, Ferdinando F. Samuelson, Lynne A. TI Template-assisted synthesis of self-doped polyaniline: Morphological effects of templates on the conductivity SO MACROMOLECULAR RAPID COMMUNICATIONS LA English DT Article ID SULFONATED POLYANILINE; ENZYMATIC-SYNTHESIS; PEDOT-PSS; POLYMERIZATION; ACID; WATER; PEROXIDASE; POLYMERS; SOLVENTS; FILMS AB Self-doped sulfonated polyaniline (PSA) has been synthesized on the surface of micellar nanoparticles made from positively charged surfactants by biocatalysis. The conformation forced by the electrostatic charge interactions between the positively charged micelle and the negatively charged PSA increases the conductivity of the PSA by three orders of magnitude. The pure PSA recovered from ion exchange, however, shows quite similar electrical properties compared with sulfonated polyanilines reported earlier. The increased conductivity of PSA complexes is as a result of the increased charge carrier concentration caused by a certain conformational locking. C1 Univ Massachusetts, Ctr Adv Mat, Dept Chem & Phys, Lowell, MA 01854 USA. Korea Res Inst Chem Technol, Photon & Elect Mat Team, Taejon 305343, South Korea. Univ Massachusetts, Ctr Nanomgf, Lowell, MA 01854 USA. USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Kumar, J (reprint author), Univ Massachusetts, Ctr Adv Mat, Dept Chem & Phys, Lowell, MA 01854 USA. EM Jayant_Kumar@uml.edu NR 40 TC 5 Z9 5 U1 0 U2 5 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY SN 1022-1336 J9 MACROMOL RAPID COMM JI Macromol. Rapid Commun. PD JUN 14 PY 2007 VL 28 IS 12 BP 1356 EP 1360 DI 10.1002/marc.200700133 PG 5 WC Polymer Science SC Polymer Science GA 186ND UT WOS:000247784500009 ER PT J AU Wang, Y Li, L Yang, K Samuelson, LA Kumar, J AF Wang, Yanping Li, Lian Yang, Ke Samuelson, Lynne A. Kumar, Jayant TI Nanocrystalline TiO2-catalyzed solid-state polymerization of diacetylene in the visible region SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID SENSITIZED SOLAR-CELLS; LOW-COST; PHOTOCATALYSIS; POLYMERS AB An amphiphilic diacetylene, 10,12-pentacosadiynoic acid, was in-situ topochemically polymerized within a TiO2 nanostructure under visible light irradiation. The red shift of the wavelength at which the polymerization occurs can be attributed to the photocatalytic effect of TiO2 upon absorption of irradiation. Since visible light can be transmitted through the entire nanoporous TiO2 film, it is possible to obtain complete polymerization of the diacetylene monomers inside the TiO2 nanopores so as to provide an approach toward fabrication of the polydiacetylene/TiO2 nanocomposite structure and further development of optoelectronic devices. C1 Univ Massachusetts, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. Univ Massachusetts, Ctr Adv Mat, Dept Phys & Appl Phys, Lowell, MA USA. USA, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Samuelson, LA (reprint author), Univ Massachusetts, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA. EM lynne.samuelson@us.army.mil; jayant_kumar@uml.edu NR 12 TC 25 Z9 26 U1 2 U2 21 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD JUN 13 PY 2007 VL 129 IS 23 BP 7238 EP + DI 10.1021/ja071296c PG 3 WC Chemistry, Multidisciplinary SC Chemistry GA 176GH UT WOS:000247072300016 PM 17516646 ER PT J AU Ohrt, C Obare, P Nanakorn, A Adhiambo, C Awuondo, K O'Meara, WP Remich, S Martin, K Cook, E Chretien, JP Lucas, C Osoga, J McEvoy, P Owaga, ML Odera, JS Ogutu, B AF Ohrt, Colin Obare, Peter Nanakorn, Ampon Adhiambo, Christine Awuondo, Ken O'Meara, Wendy Prudhomme Remich, Shon Martin, Kurt Cook, Earnest Chretien, Jean-Paul Lucas, Carmen Osoga, Joseph McEvoy, Peter Owaga, Martin Lucas Odera, James Sande Ogutu, Bernhards TI Establishing a malaria diagnostics centre of excellence in Kisumu, Kenya SO MALARIA JOURNAL LA English DT Article ID PLASMODIUM-FALCIPARUM; PARASITE DENSITY; HEALTH-CARE; MICROSCOPY; IDENTIFICATION; QUALITY; IMPACT; VIVAX; GHANA; FIELD AB Background: Malaria microscopy, while the gold standard for malaria diagnosis, has limitations. Efficacy estimates in drug and vaccine malaria trials are very sensitive to small errors in microscopy endpoints. This fact led to the establishment of a Malaria Diagnostics Centre of Excellence in Kisumu, Kenya. The primary objective was to ensure valid clinical trial and diagnostic test evaluations. Key secondary objectives were technology transfer to host countries, establishment of partnerships, and training of clinical microscopists. Case description: A twelve-day " long" and a four- day " short" training course consisting of supervised laboratory practicals, lectures, group discussions, demonstrations, and take home assignments were developed. Well characterized slides were developed and training materials iteratively improved. Objective pre- and post- course evaluations consisted of 30 slides ( 19 negative, 11 positive) with a density range of 50 - 660 parasites/ mu l, a written examination ( 65 questions), a photographic image examination ( 30 images of artifacts and species specific characteristics), and a parasite counting examination. Discussion and Evaluation: To date, 209 microscopists have participated from 11 countries. Seventy-seven experienced microscopists participated in the " long" courses, including 47 research microscopists. Sensitivity improved by a mean of 14% (CI 9 - 19%) from 77% baseline (CI 73 - 81 %), while specificity improved by a mean of 17% (CI 11 - 23%) from 76% (CI 70 - 82%) baseline. Twenty-three microscopists who had been selected for a four- day refresher course showed continued improvement with a mean final sensitivity of 95% (CI 91 - 98%) and specificity of 97% (CI 95 - 100%). Only 9% of those taking the pre- test in the " long" course achieved a 90% sensitivity and 95% specificity, which increased to 61% of those completing the " short" course. All measures of performance improved substantially across each of the five organization types and in each course offered. Conclusion: The data clearly illustrated that false positive and negative malaria smears are a serious problem, even with research microscopists. Training dramatically improved performance. Quality microscopy can be provided by the Centre of Excellence concept. This concept can be extended to other diagnostics of public health importance, and comprehensive disease control strategies. C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Kenya Govt Med Res Ctr, Clin Res Ctr, Malaria Diagnost Ctr Excellence, Kismu, Kenya. US Army Med Unit Kenya, Water Reed Project, Kismu, Kenya. Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA. Naval Med Res Ctr Detachment, Lima, Peru. Armed Forces Inst Pathol, Washington, DC 20306 USA. Ctr Dis Control, Kisumu, Kenya. Kenya Govt Med Res Ctr, Kisumu, Kenya. RP Ohrt, C (reprint author), Walter Reed Army Inst Res, Robert Grant Ave, Silver Spring, MD 20910 USA. EM colin.ohrt@us.army.mil; pobare@wrp-ksm.org; ampon2486@yahoo.com; CAdhiambo@wrp-ksm.org; kawuondo@kilifi.kemri-wellcome.org; prudhomw@mail.nih.gov; shon.remich2@amedd.army.mil; kurt.martin@us.army.mil; ecook@wrp-ksm.org; Jean-Paul.Chretien@na.amedd.army.mil; clucas@nmrcd.med.navy.mil; josoga@wrp-ksm.org; mcevoy@afip.osd.mil; jsande@wrp-ksm.org; MOwaga@ke.cdc.gov; bogutu@wrp-ksm.org OI Chretien, Jean-Paul/0000-0001-8143-6823 NR 24 TC 0 Z9 0 U1 0 U2 2 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1475-2875 J9 MALARIA J JI Malar. J. PD JUN 12 PY 2007 VL 6 AR 7 DI 10.1186/1475-2875-6-79 PG 9 WC Infectious Diseases; Parasitology; Tropical Medicine SC Infectious Diseases; Parasitology; Tropical Medicine GA 194ML UT WOS:000248348400001 ER PT J AU Vispute, RD Hullavarad, S Luykx, A Young, D Dhar, S Venkatesan, T Jones, KA Zheleva, TS Ervin, M Derenge, M AF Vispute, R. D. Hullavarad, S. Luykx, A. Young, D. Dhar, S. Venkatesan, T. Jones, K. A. Zheleva, T. S. Ervin, M. Derenge, M. TI Epitaxy and recrystallization kinetics of TaC thin films on SiC for high temperature processing of semiconductor devices SO APPLIED PHYSICS LETTERS LA English DT Article ID TANTALUM CARBIDE; DIFFUSION-BARRIERS; OHMIC CONTACTS; DEPOSITION; GROWTH; NITRIDE; DIODES; CU AB The authors report the epitaxial growth of cubic TaC thin films on 4H-SiC (0001) substrates by pulsed laser deposition and their recrystallization kinetics. The growth temperature for epitaxy was found to be 1000 degrees C. The activation energy for the recrystallization was 1.5 eV. High temperature annealing produced changes in the surface morphology which caused grain growth and created pinholes through a recrystallization process in the films deposited at lower temperatures. The films deposited at higher temperatures remained virtually unchanged. Implications of these results are discussed in the context of the development of future high temperature and high-power electronic devices. (c) 2007 American Institute of Physics. C1 Univ Maryland, Ctr Superconduct Res, Dept Phys, College Pk, MD 20742 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Vispute, RD (reprint author), Univ Maryland, College Pk, MD 20742 USA. EM vispute@squid.umd.edu RI Venkatesan, Thirumalai/E-1667-2013 NR 20 TC 3 Z9 3 U1 0 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 11 PY 2007 VL 90 IS 24 AR 241917 DI 10.1063/1.2748858 PG 3 WC Physics, Applied SC Physics GA 179QR UT WOS:000247305400039 ER PT J AU Mishchenko, MI Liu, L Videen, G AF Mishchenko, Michael I. Liu, Li Videen, Gorden TI Conditions of applicability of the single-scattering approximation SO OPTICS EXPRESS LA English DT Article ID LIGHT-SCATTERING; PARTICLES; MATRICES; POLARIZATION AB We employ the numerically exact superposition T-matrix method to perform extensive computations of electromagnetic scattering by small volume elements filled with 8 randomly distributed wavelength-sized spherical particles. The results of these computations are used to examine quantitatively the conditions of applicability of the single-scattering approximation (SSA). We show that one may need large inter-particle distances and low packing densities in order to make the SSA sufficiently accurate. (C) 2007 Optical Society of America. C1 NASA, Goddard Inst Space Studies, New York, NY 10025 USA. AMSRD ARL CI EM, US Army Res Lab, Adelphi, MD 20783 USA. RP Mishchenko, MI (reprint author), NASA, Goddard Inst Space Studies, 2880 Broadway, New York, NY 10025 USA. EM mmishchenko@giss.nasa.gov RI Mishchenko, Michael/D-4426-2012 NR 16 TC 18 Z9 19 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1094-4087 J9 OPT EXPRESS JI Opt. Express PD JUN 11 PY 2007 VL 15 IS 12 BP 7522 EP 7527 DI 10.1364/OE.15.007522 PG 6 WC Optics SC Optics GA 194QU UT WOS:000248359700050 PM 19547076 ER PT J AU Courville, ZR Albert, MR Fahnestock, MA Cathles, LM Shuman, CA AF Courville, Z. R. Albert, M. R. Fahnestock, M. A. Cathles, L. M. Shuman, C. A. TI Impacts of an accumulation hiatus on the physical properties of firn at a low-accumulation polar site SO JOURNAL OF GEOPHYSICAL RESEARCH-EARTH SURFACE LA English DT Article ID EAST ANTARCTIC PLATEAU; SNOW ACCUMULATION; TEMPORAL VARIABILITY; ICE-SHEET; GREENLAND; SURFACE; METAMORPHISM; PARAMETERS; VICINITY; STATION AB Recent field investigations of a megadune region of East Antarctica provide evidence that differences in grain size, thermal conductivity, and permeability across a megadune profile are due to spatial accumulation variability in the absence of significant microclimate variations. The megadunes are low-amplitude (2-8 m), long-wavelength (2-5 km) bands with perceptible but low accumulation ( less than 40 mm water equivalent (weq) yr(-1)) and accumulation hiatus within several kilometers proximity, as determined by remote sensing, surface feature classification, and ground-penetrating radar profiling. Our hypothesis that accumulation rate impacts the extent of temperature gradient-driven metamorphic growth in low accumulation rate sites is supported by measurements of various firn physical properties. Relatively small differences in accumulation rate (less than 40 mm weq yr(-1)) result in large differences in physical properties, including grain size, thermal conductivity, and permeability, which are apparent in satellite-based microwave data from both passive and active sensors. The differences in physical snow structure between low-accumulation areas and accumulation hiatus areas in the near surface are sufficiently distinct that evidence of past accumulation hiatus should be observable in the physical and chemical properties of an ice core record. C1 USA, Cold Reg Res & Engn Lab, Cyrospher & Terr Sci Div, Hanover, NH 03755 USA. Univ Chicago, Dept Geophys Sci, Chicago, IL 60637 USA. Univ New Hampshire, Inst Study Earth Oceans & Space, Durham, NH 03824 USA. NASA, Goddard Space Flight Ctr, Cryospher Sci Branch, Greenbelt, MD 20771 USA. Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA. RP Courville, ZR (reprint author), USA, Cold Reg Res & Engn Lab, Cyrospher & Terr Sci Div, 72 Lyme Rd, Hanover, NH 03755 USA. EM zoe.courville@dartmouth.edu RI Fahnestock, Mark/N-2678-2013; OI Albert, Mary/0000-0001-7842-2359 NR 42 TC 34 Z9 34 U1 1 U2 13 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-EARTH JI J. Geophys. Res.-Earth Surf. PD JUN 8 PY 2007 VL 112 IS F2 AR F02030 DI 10.1029/2005JF000429 PG 11 WC Geosciences, Multidisciplinary SC Geology GA 177GO UT WOS:000247141800001 ER PT J AU Ricci, F Lai, RY Heeger, AJ Plaxco, KW Sumner, JJ AF Ricci, Francesco Lai, Rebecca Y. Heeger, Alan J. Plaxco, Kevin W. Sumner, James J. TI Effect of molecular crowding on the response of an electrochemical DNA sensor SO LANGMUIR LA English DT Article ID MIXED DNA/ALKYLTHIOL MONOLAYERS; SEQUENCE-SPECIFIC DETECTION; SURFACE-PLASMON RESONANCE; LABEL-FREE DETECTION; MODIFIED ELECTRODES; BEACON BIOSENSORS; HYBRIDIZATION; REAGENTLESS; GOLD; OLIGONUCLEOTIDES AB E-DNA sensors, the electrochemical equivalent of molecular beacons, appear to be a promising means of detecting oligonucleotides. E-DNA sensors are comprised of a redox-modified (here, methylene blue or ferrocene) DNA stem-loop covalently attached to an interrogating electrode. Because E-DNA signaling arises due to binding-induced changes in the conformation of the stem-loop probe, it is likely sensitive to the nature of the molecular packing on the electrode surface. Here we detail the effects of probe density, target length, and other aspects of molecular crowding on the signaling properties, specificity, and response time of a model E-DNA sensor. We find that the highest signal suppression is obtained at the highest probe densities investigated, and that greater suppression is observed with longer and bulkier targets. In contrast, sensor equilibration time slows monotonically with increasing probe density, and the specificity of hybridization is not significantly affected. In addition to providing insight into the optimization of electrochemical DNA sensors, these results suggest that E-DNA signaling arises due to hybridization-linked changes in the rate, and thus efficiency, with which the redox moiety collides with the electrode and transfers electrons. C1 Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA. Univ Calif Santa Barbara, Inst Polymers & Organ Solids, Santa Barbara, CA 93106 USA. USA, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA. RP Plaxco, KW (reprint author), Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA. EM kwp@chem.ucsb.edu; jsumner@arl.army.mil RI Ricci, Francesco/I-9985-2012; Plaxco, Kevin/O-1793-2013; OI Plaxco, Kevin/0000-0003-4772-8771; Ricci, Francesco/0000-0003-4941-8646 FU NIBIB NIH HHS [R01 EB002046, R01 EB002046-06A1] NR 41 TC 170 Z9 171 U1 9 U2 70 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0743-7463 J9 LANGMUIR JI Langmuir PD JUN 5 PY 2007 VL 23 IS 12 BP 6827 EP 6834 DI 10.1021/la700328r PG 8 WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA 172AN UT WOS:000246776600053 PM 17488132 ER PT J AU Wang, YL Ren, F Lim, W Norton, DP Pearton, SJ Kravchenko, II Zavada, JM AF Wang, Yu-Lin Ren, F. Lim, Wantae Norton, D. P. Pearton, S. J. Kravchenko, I. I. Zavada, J. M. TI Room temperature deposited indium zinc oxide thin film transistors SO APPLIED PHYSICS LETTERS LA English DT Article ID FIELD-EFFECT TRANSISTOR; OPTICAL-PROPERTIES; CHANNEL LAYER; ZNO AB Depletion-mode indium zinc oxide (IZO) channel thin film transistors were fabricated on glass substrates from layers deposited at room temperature using rf magnetron sputtering. The threshold voltage was in the range from -5.5 to -6.5 V depending on gate dielectric (SiO2) thickness and the drain current on-to-off ratio was similar to 10(5). The maximum field effect mobility in the channel was similar to 4.5 cm(2) V-1 s(-1), lower than the Hall mobility of similar to 17 cm(2) V-1 s(-1) in the same layers, suggesting a strong influence of scattering due to trapped charges at the SiO2-IZO interface. The low deposition and processing temperatures make these devices suitable for applications requiring flexible substrates. (c) 2007 American Institute of Physics. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Gainesville, FL 32611 USA. USA, Res Off, Div Elect, Res Triangle Pk, NC 27709 USA. RP Pearton, SJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Kravchenko, Ivan/K-3022-2015 OI Kravchenko, Ivan/0000-0003-4999-5822 NR 22 TC 98 Z9 102 U1 3 U2 42 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 4 PY 2007 VL 90 IS 23 AR 232103 DI 10.1063/1.2746084 PG 3 WC Physics, Applied SC Physics GA 177HZ UT WOS:000247145500031 ER PT J AU Tovanabutra, S Kijak, GH Beyrer, C Gammon-Richardson, C Sakkhachornphop, S Vongchak, T Jittiwutikarn, J Razak, MH Sanders-Buell, E Robb, ML Suriyanon, V Birx, DL Michael, NL Celentano, DD McCutchan, FE AF Tovanabutra, Sodsai Kijak, Gustavo H. Beyrer, Chris Gammon-Richardson, Christiana Sakkhachornphop, Supachai Vongchak, Tasanai Jittiwutikarn, Jaroon Razak, Myat Htoo Sanders-Buell, Eric Robb, Merlin L. Suriyanon, Vinai Birx, Deborah L. Michael, Nelson L. Celentano, David D. McCutchan, Francine E. TI Identification of CRF34_01B, a second circulating recombinant form unrelated to and more complex than CRF15_01B, among injecting drug users in northern Thailand SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; HIV TYPE-1; MOLECULAR EPIDEMIOLOGY; RISK POPULATIONS; BC RECOMBINANT; MBEYA REGION; SUBTYPES; CHINA; BREAKPOINTS; INFECTION AB In Thailand, the circulating HIV-1 strains include CRF01_AE, subtype B, and their recombinants. Genotyping and full-genome sequencing had previously identified circulating recombinant form CRF15_01B within a cohort of 347 HIV-1-infected individuals enrolled in the Opiate Users Research (OUR) study in northern Thailand. Using an improved MHAbce in six to eight genome regions and archived OUR serum samples, seven strains were identified with a new and complex 01/B recombinant pattern in common, different from that of CRF15_01B. Complete sequencing of three strains, amplified from serum as overlapping half-genomes, confirmed their common recombinant structure, mostly CRF01_AE, but with segments of subtype B in pol and gp41, plus a region of frequent 01/B crossovers in pol. OUR strains 1969P, 2275P, and 2478P were from individuals without direct epidemiological linkage and thus establish CRF34_01B. More comprehensive HIV-1 prevention and treatment programs in IDU can help to limit the growing complexity of HIV-1 strains in Thailand. C1 Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Rockville, MD 20850 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA. Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand. No Drug Treatment Ctr, Chiang Mai, Thailand. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. RP Tovanabutra, S (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, 1600 E Gude Dr, Rockville, MD 20850 USA. EM stovanabutra@hivresearch.org FU NIDA NIH HHS [1 R01 DA 11133] NR 21 TC 45 Z9 45 U1 0 U2 1 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUN PY 2007 VL 23 IS 6 BP 829 EP 833 DI 10.1089/aid.2006.0300 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 184FH UT WOS:000247626000011 PM 17604547 ER PT J AU Sanders-Buell, E Saad, MD Abed, AM Bose, M Todd, CS Strathdee, SA Botros, BA Safi, N Earhart, KC Scott, PT Michael, N McCutchan, FE AF Sanders-Buell, E. Saad, M. D. Abed, A. M. Bose, M. Todd, C. S. Strathdee, S. A. Botros, B. A. Safi, N. Earhart, K. C. Scott, P. T. Michael, N. McCutchan, F. E. TI A nascent HIV type 1 epidemic among injecting drug users in Kabul, Afghanistan is dominated by complex AD recombinant strain, CRF35_AD SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID FORMER SOVIET-UNION; INTERSUBTYPE RECOMBINANTS; CIRCULATING RECOMBINANT; GENETIC DIVERSITY; CENTRAL MYANMAR; HIGH PREVALENCE; BC RECOMBINANT; INFECTION; CHINA; THAILAND AB Injecting drug use (IDU), common in global centers of heroin production, confers significant risk for HIV-1 infection. Once introduced into IDU networks, an explosive rise in HIV-1 infection typically occurs, fueled principally by needle sharing. New HIV-1 epidemics in IDUs have occurred in Russia, China, Thailand, Spain, Iran, and in other countries, and some have spread into other risk groups in their respective countries. In Afghanistan, the introduction of HIV-1 into IDU networks has begun, but a recent report of 3% HIV-1 prevalence suggests that the epidemic is still at an early stage. Here we establish, by complete genome sequencing and phylogenetic analysis of four viral strains from Afghan IDUs, that all are the same complex recombinant strain, combining HIV-1 subtypes A and D and herein termed CRF35_AD. Published partial HIV-1 sequences from an HIV-1 epidemic among IDUs in Iran, already at 23.2% HIV-1 prevalence, are either CRF35_AD or a related recombinant. Voluntary HIV-1 screening and harm reduction programs in Afghanistan, applied now, could limit the spread of HIV-1, both in IDUs and in other social networks. C1 Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, Rockville, MD 20850 USA. USN, Med Res Unit 3, Cairo, Egypt. Islam Republ Afghanistan, Minist Publ Hlth, Natl HIV AIDS Control Program, Kabul, Afghanistan. Univ Calif San Diego, Div Int Hlth & Cross Cultural Med, La Jolla, CA 92073 USA. RP Sanders-Buell, E (reprint author), Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Div Retrovirol, Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM esanders@hivresearch.org RI Strathdee, Steffanie/B-9042-2009; Saad, Magdi/H-5561-2013; Valle, Ruben/A-7512-2013 OI Saad, Magdi/0000-0003-2111-8115; FU FIC NIH HHS [K01TW007408] NR 33 TC 33 Z9 36 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUN PY 2007 VL 23 IS 6 BP 834 EP 839 DI 10.1089/aid.2006.0299 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 184FH UT WOS:000247626000012 PM 17604548 ER PT J AU Narayan, R Perkins, RM Berbano, EP Yuan, CM Neff, RT Sawyers, ES Yeo, FE Vidal-Trecan, GM Abbott, KC AF Narayan, Rajeev Perkins, Robert M. Berbano, Elizabeth P. Yuan, Christina M. Neff, Robert T. Sawyers, Eric S. Yeo, Fred E. Vidal-Trecan, Gwenaelle M. Abbott, Kevin C. TI Parathyroidectomy versus cinacalcet hydrochloride-based medical therapy in the management of hyperparathyroidism in ESRD: A cost utility analysis SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE medical decision analysis; cinacalcet hydrochloride; parathyroidectomy; cost-effectiveness; cost utility; hyperparathyroidism; parathyroid hormone (PTH) ID QUALITY-OF-LIFE; CHRONIC-HEMODIALYSIS PATIENTS; TRANSPLANT WAITING-LIST; ORAL CALCIMIMETIC AGENT; STAGE RENAL-DISEASE; SECONDARY HYPERPARATHYROIDISM; UNITED-STATES; HORMONE LEVELS; AMG-073; HCL AB Background: Previously, patients with end-stage renal disease (ESRD) with uncontrolled hyperparathyroidism had few options other than parathyroidectomy, which was reserved for patients refractory to medical therapy. Newer calcimimetic agents, such as cinacalcet, may be an alternative, but raise the possibility of indefinite medical treatment that also would increase costs. Study Design: Cost utility analysis. Setting & Population: Base case consisted of prevalent adult US patients with ESRD refractory to management with standard medical therapy. Characteristics were obtained from patients who underwent parathyroidectomy in 2001, and, for purposes of comparison, patients in whom cinacalcet was used were assigned similar characteristics. All data came from preexisting literature and trials or from US Renal Data System analysis files. Intervention: Use of cinacalcet hydrochloride versus parathyroidectomy. Perspective & Time Frame: Medicare and societal costs and quality-adjusted life-years from the date of parathyroidectomy or use of cinacalcet followed up for 2 years, respectively. Model & Outcomes: Primary outcomes were cost (measured in US dollars) and cost utility measured using cost per quality-adjusted life-years. Results: At base-case surgical and drug costs, surgical and drug success rates, complication rates/costs, and benefit from correction of hyperparathyroidism, parathyroidectomy was found to be both less expensive and more cost-effective at 7.25 +/- 0.25 months. Parathyroidectomy became more cost-effective at 15.28 to 16.32 months at the upper limit of sensitivity analysis, when drug/surgical costs and success/complication rates/costs were maximally weighted to favor cinacalcet-based medical therapy. Limitations: We assumed current costs of both cinacalcet and parathyroidectomy and assumed cinacalcet use would be indefinite. Conclusions: For patients with ESRD with uncontrolled hyperparathyroidism who are good candidates for either drug therapy or surgery, cinacalcet hydrochloride is the most cost-effective modality if the patient is to remain on dialysis therapy for 7.25 +/- 0.25 months. Cinacalcet may be more optimal if used in patients who have high risk of mortality or who would expect to receive a kidney transplant quickly. For other subgroups, parathyroidectomy dominated. C1 Walter Reed Army Med Ctr, Div Nephrol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Div Internal Med, Washington, DC 20307 USA. Natl Naval Med Ctr, Div Nephrol, Bethesda, MD USA. Univ Paris 05, Fac Med Paris 5, Dept Sante Publ, Paris, France. RP Abbott, KC (reprint author), Walter Reed Army Med Ctr, Div Nephrol, Washington, DC 20307 USA. EM kevin.abbott@na.amedd.army.mil OI Vidal-Trecan, Gwenaelle/0000-0002-2010-0207; Abbott, Kevin/0000-0003-2111-7112 NR 35 TC 58 Z9 58 U1 0 U2 3 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0272-6386 EI 1523-6838 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD JUN PY 2007 VL 49 IS 6 BP 801 EP 813 DI 10.1053/j.ajkd.2007.03.009 PG 13 WC Urology & Nephrology SC Urology & Nephrology GA 197QI UT WOS:000248570300012 PM 17533023 ER PT J AU Salvalaggio, PR Schnitzler, MA Abbott, KC Brennan, DC Irish, W Takemoto, SK Axelrod, D Santos, LS Kocak, B Willoughby, L Lentine, KL AF Salvalaggio, P. R. Schnitzler, M. A. Abbott, K. C. Brennan, D. C. Irish, W. Takemoto, S. K. Axelrod, D. Santos, L. S. Kocak, B. Willoughby, L. Lentine, K. L. TI Patient and graft survival implications of simultaneous pancreas kidney transplantation from old donors SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Article DE donor age; graft failure; mortality; pancreas-kidney transplantation; simultaneous; waiting list ID RISK-FACTORS; MARGINAL DONORS; ORGAN DONATION; UNITED-STATES; OUTCOMES; UNDERUTILIZATION; FAILURE; IMPACT; AGE AB We investigated graft and patient survival implications of simultaneous pancreas kidney (SPK) transplant from old donors. Data describing patients with type 1 diabetes mellitus listed for an SPK transplant from 1994 to 2005 were drawn from Organ Procurement and Transplant Network registries. Allograft survival, patient survival and long-term survival expectations among SPK recipients from young (age < 45 years) and old (age >= 45 years) donors were modeled by multivariate regression. We also examined predictors of reduced early access to young donor transplants. Of 16 496 eligible SPK candidates, 8850 patients (53.6%) received an SPK transplant and 776 (8.8%) of these transplants were from old donors. Reasonable 5-year, death-censored kidney (77.8 %) and pancreas (71.3%) survivals were achieved with old donors. SPK transplantation from both young and old donors predicted lower mortality compared to continued waiting. An additional expected wait of 1.5 years for a young donor equalized long-term survival expectations to that achieved with use of old donors. Early allocation of young donor transplants declined in the more recent era and varied by region, candidate age, blood type and sensitization. We conclude that old SPK donors should be considered for patients with decreased access to young donor transplants. Prospective evaluation of this practice is needed. C1 St Louis Univ, Sch Med, Ctr Outcomes Res, St Louis, MO 63103 USA. St Louis Univ, Sch Med, Dept Surg, St Louis, MO USA. Walter Reed Army Med Ctr, Serv Nephrol, Washington, DC 20307 USA. St Louis Univ, Sch Med, Div Nephrol, St Louis, MO USA. Res Triangle Inst, Res Triangle Pk, NC 27709 USA. Dartmouth Hitchcock Med Ctr, Dept Surg, Hanover, NH USA. Ondokuz Mayis Univ, Dept Urol, Samsun, Turkey. RP Lentine, KL (reprint author), St Louis Univ, Sch Med, Ctr Outcomes Res, St Louis, MO 63103 USA. EM lentine.krista@stanfordalumni.org RI Kocak, Burak/A-3433-2009; OI Abbott, Kevin/0000-0003-2111-7112 FU NIDDK NIH HHS [K24-DK002886]; PHS HHS [K08-0730306] NR 33 TC 37 Z9 37 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD JUN PY 2007 VL 7 IS 6 BP 1561 EP 1571 DI 10.1111/j.1600-6143.2007.01818.x PG 11 WC Surgery; Transplantation SC Surgery; Transplantation GA 169EY UT WOS:000246576700017 PM 17511681 ER PT J AU Brochero, HHL Li, C Wilkerson, RC AF Brochero, Helena H. L. Li, Cong Wilkerson, Richard C. TI A newly recognized species in the Anopheles (Nyssorhynchus) albitarsis complex (Diptera : Culicidae) from Puerto Carreno, Colombia SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID POLYMERASE-CHAIN-REACTION; MALARIA VECTOR; IDENTIFICATION; ARGENTINA; BRAZIL; GENE AB We report a previously unrecognized mosquito species from eastern Colombia belonging to the Anopheles (Nyssorhynchus) albitarsis complex. We provisionally name this taxon An. albitarsis species "F." Until now, the only members of the Albitarsis Complex recorded from north of the Amazon River have been An. marajoara and a putative phylogenetic species, An. albitarsis "E." As with the other largely monomorphic species in the complex, we were able to detect its presence using ribosomal DNA internal transcribed spacer 2 (rDNA ITS2) and partial white gene sequences. Unlike An. marajoara, but in common with other species in the complex, An. albitarsis F lacks the white gene fourth intron. This species is sympatric with An. marajoara in a malaria-endemic area in Puerto Carreno, Vichada Department, Colombia. It could be an important current and/or historical vector of human malaria parasites at this locality and, depending on its actual distribution, elsewhere in Colombia and Venezuela. C1 Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA. Inst Nacl Salud, Entomol Lab, Bogota, Colombia. RP Wilkerson, RC (reprint author), 4210 Silver Hill Rd, Suitland, MD 20746 USA. EM wilkersonr@si.edu FU NIAID NIH HHS [AI RO154139] NR 29 TC 26 Z9 26 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 2007 VL 76 IS 6 BP 1113 EP 1117 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 176WV UT WOS:000247116500021 PM 17556620 ER PT J AU Stojadinovic, A Nissan, A Protic, M Adair, CF Prus, D Usaj, S Howard, RS Radovanovic, D Breberina, M Shriver, CD Grinbaum, R Nelson, JM Brown, TA Freund, HR Potter, JF Peretz, T Peoples, GE AF Stojadinovic, Alexander Nissan, Aviram Protic, Mladjan Adair, Carol F. Prus, Diana Usaj, Slavica Howard, Robin S. Radovanovic, Dragan Breberina, Milan Shriver, Craig D. Grinbaum, Ronit Nelson, Jeffery M. Brown, Tommy A. Freund, Herbert R. Potter, John F. Peretz, Tamar Peoples, George E. TI Prospective randomized study comparing sentinel lymph node evaluation with standard pathologic evaluation for the staging of colon carcinoma - Results from the United States Military Cancer Institute Clinical Trials Group study GI-01 SO ANNALS OF SURGERY LA English DT Article ID B-COLORECTAL-CARCINOMA; PROGNOSTIC-SIGNIFICANCE; MULTICENTER TRIAL; TUMOR-CELLS; EX-VIVO; MICROMETASTASES; IDENTIFICATION; VALIDATION; METASTASES; SURVIVAL AB Background: The principal role of sentinel lymph node (SLN) sampling and ultrastaging in colon cancer is enhanced staging accuracy. The utility of this technique for patients with colon cancer remains controversial. Purpose: This multicenter randomized trial was conducted to determine if focused assessment of the SLN with step sectioning and immunohistochemistry (IHC) enhances the ability to stage the regional nodal basin over conventional histopathology in patients with resectable colon cancer. Patients and Methods: Between August 2002 and April 2006 we randomly assigned 161 patients with stage I-III colon cancer to standard histopathologic evaluation or SLN mapping (ex vivo, subserosal, peritumoral, 1% isosulfan blue dye) and ultrastaging with pan-cytokeratin IHC in conjunction with standard histopathology. SLN-positive disease was defined as individual tumor cells or cell aggregates identified by hematoxylin and eosin (H&E) and/or IHC. Primary end point was the rate of nodal upstaging. Results: Significant nodal upstaging was identified with SLN ultrastaging (Control vs. SLN: 38.7% vs. 57.3%, P = 0.019). When SLNs with cell aggregates <= 0.2 min in size were excluded, no statistically significant difference in node-positive rate was apparent between the control and SLN arms (38.7% vs. 39.0%, P = 0.97). However, a 10.7% (6/56) nodal upstaging was identified by evaluation of H&E stained step sections of SLNs among study arm patients who would have otherwise been staged node-negative (NO) by conventional pathologic assessment alone. Conclusion: SLN mapping, step sectioning, and immunohistochemistry (IHC) identifies small volume nodal disease and improves staging in patients with resectable colon cancer. A prospective trial is ongoing, to determine the clinical significance of colon cancer micrometastasis in sentinel lymph nodes. C1 US Mil Canc Inst, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Dept Surg, Div Surg Oncol, Washington, DC 20307 USA. Hadassah Hebrew Univ Med Ctr, Dept Surg, Jerusalem, Israel. Clin Ctr Novi Sad, Inst Surg, Clin Abdominal & Endocrine Surg, Novi Sad, Serbia. Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA. Hadassah Hebrew Univ Med Ctr, Dept Pathol, Jerusalem, Israel. Inst Oncol Vojvodina, Dept Pathol, Sremska Kamenica, Serbia. Walter Reed Army Med Ctr, Dept Clin Invest, Div Biostat, Washington, DC 20307 USA. Univ Surg Hosp Dr Dragisa Misovic, Dept Surg, Belgrade, Serbia. Inst Oncol Vojvodina, Dept Surg Oncol, Sremska Kamenica, Serbia. Walter Reed Army Med Ctr, Dept Surg, Div Colorectal Surg, Washington, DC 20307 USA. Madigan Army Med Ctr, Dept Surg, Div Colorectal Surg, Tacoma, WA 98431 USA. Hadassah Hebrew Univ Med Ctr, Dept Oncol, Jerusalem, Israel. Brooke Army Med Ctr, Dept Surg, Div Surg Oncol, Ft Sam Houston, TX 78234 USA. RP Stojadinovic, A (reprint author), US Mil Canc Inst, 6900 Georgia Ave,Room 5C27B NW, Washington, DC 20307 USA. EM alexander.stojadinovic@na.amedd.anny.mil OI Knezevic-Usaj, Slavica/0000-0001-5082-0515 NR 38 TC 68 Z9 68 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD JUN PY 2007 VL 245 IS 6 BP 846 EP 857 DI 10.1097/01.sla.0000256390.13550.26 PG 12 WC Surgery SC Surgery GA 173KW UT WOS:000246873000003 PM 17522508 ER PT J AU Horvath, EE Murray, CK Vaughan, GM Chung, KK Hospenthal, DR Wade, CE Holcomb, JB Wolf, SE Mason, AD Cancio, LC AF Horvath, Edward E. Murray, Clinton K. Vaughan, George M. Chung, Kevin K. Hospenthal, Duane R. Wade, Charles E. Holcomb, John B. Wolf, Steven E. Mason, Arthur D., Jr. Cancio, Leopoldo C. TI Fungal wound infection (not colonization) is independently associated with mortality in burn patients SO ANNALS OF SURGERY LA English DT Article ID EXPERIENCE; INJURY AB Objective: To analyze the occurrence of fungal wound infection (FWI) after thermal injury and its relationship to mortality. Background: FWI is an uncommon but potentially lethal complication of severe thermal injury. Methods: The records of patients with thermal burns admitted to a single burn center (1991-2002) were reviewed. Analyses accounted for total burn size (TBS, percentage body surface area), full-thickness burn size (FTBS, percentage body surface area), age, inhalation injury, sex, and fungal-status category. Fungal colonization and infection were determined histopathologically. Results: Criteria for inclusion were met by 2651 patients. Each patient's fungal-status category was defined according to the deepest level of fungal involvement observed during the hospital course: no fungus (2476 patients), fungal wound colonization (FWC, 121 patients), or fungal wound infection (FWI, 54 patients). Median TBS (9%, 47%, 64%, respectively) and mortality (5%, 27%, 76%, respectively) varied significantly among fungal-status groups. Logistic regression was used to detect significant independent associations. FWI was associated with higher TBS. Mortality was associated with TBS, FTBS, inhalation injury, FWI, and age. Unlike FWI, FWC was not independently related to mortality, the greater observed mortality in FWC being explained by other variables such as TBS. The odds ratio for FWI (8.16) suggested about the same mortality impact as augmenting TBS by 33%. A midrange TBS of 30% to 60% was required for most of the detectable association of FWI with mortality. Conclusions: FWI accompanies larger bums and is associated with mortality in burn patients, particularly in those with TBS 30% to 60%. This association is independent of burn size, inhalation injury, and age. C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78284 USA. Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78284 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Dept Med, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 9 TC 47 Z9 51 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD JUN PY 2007 VL 245 IS 6 BP 978 EP 985 DI 10.1097/01.sla.0000256914.16754.80 PG 8 WC Surgery SC Surgery GA 173KW UT WOS:000246873000020 PM 17522525 ER PT J AU Holcomb, JB McMullin, NR Pearse, L Caruso, J Wade, CE Oetyen-Gerdes, L Champion, HR Lawnick, M Farr, W Rodriguez, S Butler, FK AF Holcomb, John B. McMullin, Neil R. Pearse, Lisa Caruso, Jim Wade, Charles E. Oetyen-Gerdes, Lynne Champion, Howard R. Lawnick, Mimi Farr, Warner Rodriguez, Sam Butler, Frank K. TI Causes of death in US Special Operations Forces in the global war on terrorism - 2001-2004 SO ANNALS OF SURGERY LA English DT Article ID RECOMBINANT-FACTOR-VIIA; DAMAGE CONTROL RESUSCITATION; PREVENTABLE TRAUMA DEATHS; INJURY SEVERITY SCORE; RURAL STATE; CARE; COAGULOPATHY; RELIABILITY; INTERRATER; MORTALITY AB Background: Effective combat trauma management strategies depend upon an understanding of the epidemiology of death on the battlefield. Methods: A panel of military medical experts reviewed photographs and autopsy and treatment records for all Special Operations Forces (SOF) who died between October 2001 and November 2004 (n = 82). Fatal wounds were classified as nonsurvivable or potentially survivable. Training and equipment available at the time of injury were taken into consideration. A structured analysis was conducted to identify equipment, training, or research requirements for improved future outcomes. Results: Five (6%) of 82 casualties had died in an aircraft crash, and their bodies were lost at sea; autopsies had been performed on all other 77 soldiers. Nineteen deaths, including the deaths at sea were noncombat; all others were combat related. Deaths were caused by explosions (43%), gunshot wounds (28%), aircraft accidents (23%), and blunt trauma (6%). Seventy of 82 deaths (85%) were classified as nonsurvivable; 12 deaths (15%) were classified as potentially survivable. Of those with potentially survivable injuries, 16 causes of death were identified: 8 (50%) truncal hemorrhage, 3 (19%) compressible hemorrhage, 2 (13%) hemorrhage amenable to tourniquet, and 1 (6%) each from tension pneumothorax, airway obstruction, and sepsis. The population with nonsurvivable injuries was more severely injured than the population with potentially survivable injuries. Structured analysis identified improved methods of truncal hemorrhage control as a principal research requirement. Conclusions: The majority of deaths on the modem battlefield are nonsurvivable. Improved methods of intravenous or intracavitary, noncompressible hemostasis combined with rapid evacuation to surgery may increase survival. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Armed Forces Med Examiner Syst, Rockville, MD USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. USA, Special Operat Command, Ft Bragg, NC USA. US Special Operat Command, Tampa, FL USA. RP Holcomb, JB (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM John.Holcomb@amedd.army.mil NR 30 TC 271 Z9 276 U1 5 U2 29 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD JUN PY 2007 VL 245 IS 6 BP 986 EP 991 DI 10.1097/01.sla.0000259433.03754.98 PG 6 WC Surgery SC Surgery GA 173KW UT WOS:000246873000021 PM 17522526 ER PT J AU Johnson, JD Dennull, RA Gerena, L Lopez-Sanchez, M Roncal, NE Waters, NC AF Johnson, Jacob D. Dennull, Richard A. Gerena, Lucia Lopez-Sanchez, Miriam Roncal, Norma E. Waters, Norman C. TI Assessment and continued validation of the malaria SYBR green I-based fluorescence assay for use in malaria drug screening SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID LINKED-IMMUNOSORBENT-ASSAY; SEMIAUTOMATED MICRODILUTION TECHNIQUE; DEHYDROGENASE IMMUNODETECTION ASSAY; RICH PROTEIN-II; PLASMODIUM-FALCIPARUM; LACTATE-DEHYDROGENASE; ANTIMALARIAL-DRUGS; MICROFLUORIMETRIC METHOD; COLORIMETRIC METHOD; RESISTANT MALARIA AB Several new fluorescence malaria in vitro drug susceptibility microliter plate assays that detect the presence of malarial DNA in infected erythrocytes have recently been reported, in contrast to traditional isotopic screens that involve radioactive substrate incorporation to measure in vitro malaria growth inhibition. We have assessed and further characterized the malaria SYBR Green I-based fluorescence (MSF) assay for its ability to monitor drug resistance. In order to use the MSF assay as a drug screen, all assay conditions must be thoroughly examined. In this study we expanded upon the capabilities of this assay by including antibiotics and antifolates in the drug panel and testing folic acid-free growth conditions. To do this, we evaluated a more expansive panel of antimalarials in combination with various drug assay culture conditions commonly used in drug sensitivity screening for their activity against Plasmodium falciparum strains D6 and W2. The detection and quantitation limits of the MSF assay were 0.04 to 0.08% and similar to 0.5% parasitemia, respectively. The MSF assay quality was significantly robust, displaying a Z ' range of 0.73 to 0.95. The 50% inhibitory concentrations for each drug and culture condition combination were determined by using the MSF assay. Compared to the standard [H-3]hypoxanthine assay, the MSF assay displayed the expected parasite drug resistance patterns with a high degree of global and phenotypic correlation (r(2) >= 0.9238), regardless of which culture condition combination was used. In conclusion, the MSF assay allows for reliable one-plate high-throughput, automated malaria in vitro susceptibility testing without the expense, time consumption, and hazard of other screening assays. C1 Walter Reed Army Inst Res, Dept Parasitol, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Johnson, JD (reprint author), Walter Reed Army Inst Res, Dept Parasitol, Div Expt Therapeut, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM jacob.d.johnson@us.army.mil NR 40 TC 129 Z9 133 U1 0 U2 12 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 2007 VL 51 IS 6 BP 1926 EP 1933 DI 10.1128/AAC.01607-06 PG 8 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA 175CY UT WOS:000246991400006 PM 17371812 ER PT J AU Voss, T Warfield, K Brocato, R Barbercheck, J Kaplin, B Stein, D Bavari, S Iversen, P AF Voss, Thomas Warfield, Kelly Brocato, Rebecca Barbercheck, Joseph Kaplin, Bryan Stein, David Bavari, Sina Iversen, Patrick TI Phosphorodiamidate morpholino oligomer - Mediated inhibition of influenza a virus in mice SO ANTIVIRAL RESEARCH LA English DT Meeting Abstract CT 20th International Conference on Antiviral Research CY APR 29-MAY 03, 2007 CL Palm Spring, CA SP Int Soc Antiviral Res C1 AVI BioPharma Inc, Corvallis, OR 97333 USA. Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD JUN PY 2007 VL 74 IS 3 SI SI MA 48 BP A47 EP A47 DI 10.1016/j.antiviral.2007.01.056 PG 1 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA 161VD UT WOS:000246043600049 ER PT J AU Redd, MA Bray, DW Royer, M AF Redd, Michael A. Bray, David W. Royer, Michael TI Asymptomatic cutaneous lip plaque - Microcystic adnexal carcinoma (MAC) SO ARCHIVES OF DERMATOLOGY LA English DT Editorial Material C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. RP Redd, MA (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 2007 VL 143 IS 6 BP 791 EP + DI 10.1001/archderm.143.6.791-a PG 2 WC Dermatology SC Dermatology GA 178FU UT WOS:000247207400018 PM 17576952 ER PT J AU Bunning, ML Fox, PE Bowen, RA Komar, N Chang, GJJ Speaker, TJ Stephens, MR Nemeth, N Panella, NA Langevin, SA Gordy, P Teehee, M Bright, PR Turell, MJ AF Bunning, Michel L. Fox, Patricia E. Bowen, Richard A. Komar, Nicholas Chang, Gwong-Jen J. Speaker, Tully J. Stephens, Michael R. Nemeth, Nicole Panella, Nicholas A. Langevin, Stanley A. Gordy, Paul Teehee, Max Bright, Patricia R. Turell, Michael J. TI DNA vaccination of the American crow (Corvus brachyrhynchos) provides partial protection against lethal challenge with West Nile virus SO AVIAN DISEASES LA English DT Article DE West Nile virus; American crow; DNA vaccine; killed vaccine; oral vaccine ID EXPERIMENTAL-INFECTION; IMMUNE-RESPONSES; BIRDS; EPIDEMIOLOGY; TRANSMISSION; IMMUNIZATION; OSSIFRAGUS; STRAIN AB The New York 1999 strain of West Nile virus (WNV) is nearly 100% fatal in the American crow (Corvus brachyrhynchos). We evaluated four WNV vaccine formulations in American crows, including intramuscular (i.m.) DNA vaccine, i.m. DNA vaccine with adjuvant, orally administered microencapsulated DNA vaccine, and i.m. killed vaccine. Neutralizing antibodies developed in approximately 80% of crows that received the DNA vaccine i.m. (with or without adjuvant), and in 44% that received the killed vaccine. However, no crows that received the oral microencapsulated DNA vaccine or the placebo developed WNV antibodies. All crows were challenged 10 wk after initial vaccination. No unvaccinated crows survived challenge, and survival rates were 44% (i.m. DNA vaccine), 60% (i.m. DNA vaccine with adjuvant), 0% (oral microencapsulated DNA vaccine), and 11% (killed vaccine). Peak viremia titers in the birds that survived were significantly lower as compared to titers in birds that died. Parenteral administration of a WNV DNA vaccine was associated with reduced mortality but did nor provide sterile immunity. C1 Colorado State Univ, Coll Vet Med & Biomed Sci, Ft Collins, CO 80523 USA. Ctr Dis Control & Prevent, Ft Collins, CO 80523 USA. USAF, Off Surgeon Gen, HQ AFMOA, SGPP, Washington, DC 20032 USA. Univ Georgia, Coll Vet Med, Athens, GA 30602 USA. Temple Univ, Sch Pharm, Philadelphia, PA 19140 USA. Amer Bird Conservancy, The Plains, VA 20198 USA. USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA. RP Nemeth, N (reprint author), Colorado State Univ, Coll Vet Med & Biomed Sci, 3801 W Rampart Rd, Ft Collins, CO 80523 USA. EM nnemeth@colostate.edu NR 29 TC 19 Z9 21 U1 0 U2 10 PU AMER ASSOC AVIAN PATHOLOGISTS PI ATHENS PA 953 COLLEGE STATION RD, ATHENS, GA 30602-4875 USA SN 0005-2086 J9 AVIAN DIS JI Avian Dis. PD JUN PY 2007 VL 51 IS 2 BP 573 EP 577 DI 10.1637/0005-2086(2007)51[573:DVOTAC]2.0.CO;2 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA 176MF UT WOS:000247088700010 PM 17626486 ER PT J AU De Pol, CV Greig, JL Estrada, A Bissette, GM Bower, KS AF De Pol, Corina Van Greig, Joanna L. Estrada, Art Bissette, Gina M. Bower, Kraig S. TI Visual and flight performance recovery after PRK or LASIK in helicopter pilots SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE refractive surgery; photorefractive keratectomy; laser in situ; keratomileusis; helicopter flight performance; contrast sensitivity; low contrast acuity; military ID IN-SITU KERATOMILEUSIS; STATES-ARMY AVIATORS; PHOTOREFRACTIVE KERATECTOMY; REFRACTIVE SURGERY; LOW MYOPIA; LASER; DIOPTERS; VISION; SATISFACTION; PERSONNEL AB Introduction: Refractive surgery, specifically photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK), is becoming more accepted in the military environment. Determination of the impact on visual performance in the more demanding aviation environment was the impetus for this study. Methods: A prospective evaluation of 20 Black Hawk pilots pre-surgically and at I wk, 1 mo, and 6 mo postsurgery was conducted to assess both PRK and LASIK visual and flight performance outcomes on the return of aviators to duty. Results: Of 20 pilots, 19 returned to flight status at I mo after surgery; I PRK subject was delayed due to corneal haze and subjective visual symptoms. Improvements were seen under simulator night and night vision goggle flight after LASIK; no significant changes in flight performance were measured in the aircraft. Results indicated a significantly faster recovery of all visual performance outcomes I wk after LASIK vs. PRK, with no difference between procedures at I and 6 mo. Low contrast acuity and contrast sensitivity only weakly correlated to flight performance in the early post-operative period. Discussion: Overall flight performance assessed in this study after PRK and LASIK was stable or improved from baseline, indicating a resilience of performance despite measured decrements in visual performance, especially in PRK. More visually demanding flight tasks may be impacted by subtle changes in visual performance. Contrast tests are more sensitive to the effects of refractive surgical intervention and may prove to be a better indicator of visual recovery for return to flight status. C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP De Pol, CV (reprint author), USA, Aeromed Res Lab, POB 620577, Ft Rucker, AL 36362 USA. NR 22 TC 0 Z9 0 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2007 VL 78 IS 6 BP 547 EP 553 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 173GT UT WOS:000246862200001 ER PT J AU O'Brien, C Tharion, WJ Sils, IV Castellani, JW AF O'Brien, Catherine Tharion, William J. Sils, Ingrid V. Castellani, John W. TI Cognitive, psychomotor, and physical performance in cold air after cooling by exercise in cold water SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE immersion; temperature; prediction ID TEMPERATURE; MARKSMANSHIP; FOREARM; STRESS; TIME AB Introduction: This study evaluated performance after lowering core temperature at different rates while local tissues were either cooled (lower body) or not cooled (upper body). Methods: There were 10 men who volunteered to perform up to 8 cold water immersions (CWI) at combinations of 2 water temperatures (10 degrees C and 15 degrees C), 2 depths waist (W), chest (C)], and 2 walking speeds (0.44 or 0.88 m center dot s(-1)) until their core temperature fell to 35.5 degrees C, stabilized above that temperature, or they requested to stop. They also completed a control trial (120 min rest in 19 degrees C air). Immediately following each CWI and control, cognitive and physical performance tests were performed in cold air (11 C; CAE). Results: Overall, the CWI protocol lowered rectal temperature by 0.3-1.0 degrees C. Mean skin temperature was similar to 26 degrees C and finger temperature was similar to 15 degrees C during CAE. No statistical differences were observed across trials for any cognitive test. On the physical performance tests, step test performance was degraded similar to 12% on CWI trials compared with control, but there were no differences in manual dexterity, hand grip strength, marksmanship, or pull-ups. Conclusions: These results, indicate that cognitive performance can be maintained despite mild hypothermia, and that physical performance is related to local tissue temperature, not a moderately reduced core temperature. C1 USA, Environm Med Res Inst, Thermal & Mt Med Div, Natick, MA 01760 USA. USA, Environm Med Res Inst, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. RP O'Brien, C (reprint author), USA, Environm Med Res Inst, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA. EM kate.obrien@us.army.mil NR 30 TC 9 Z9 9 U1 1 U2 6 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 2007 VL 78 IS 6 BP 568 EP 573 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 173GT UT WOS:000246862200005 PM 17571656 ER PT J AU Panikov, NS Sizova, MV Ros, D Christodoulatos, C Balas, W Nicolich, S AF Panikov, N. S. Sizova, M. V. Ros, D. Christodoulatos, C. Balas, W. Nicolich, S. TI Biodegradation kinetics of the nitramine explosive CL-20 in soil and microbial cultures SO BIODEGRADATION LA English DT Article DE CL-20; kinetics order; growth stoichiometry; co-metabolism; microbial community; remediation strategy ID CLOSTRIDIUM SP EDB2; 2,4,6,8,10,12-HEXANITRO-2,4,6,8,10,12-HEXAAZAISOWURTZITANE CL-20; BIOTRANSFORMATION; DEGRADATION; RDX; TOXICITY; INSIGHTS; SORPTION; ENZYME; HMX AB The cyclic nitramine explosive CL-20 (C6H6N12O12, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12 -hexaazaisowurtzitane) is a relatively new energetic compound which could be a persistent organic pollutant. To follow its biodegradation dynamics, CL-20 was added to soil alone or together with organic co-substrates and N-source and incubated under oxic and anoxic conditions. Without co-substrates, the CL-20 degradation was detectable only under anoxic conditions. The highest degradation rate was found under aerobic conditions and with the addition of co-substrates, succinate and pyruvate being more efficient than acetate, glucose, starch or yeast extract. When added to intact soil, CL-20 degradation was not affected by the N content, but in soil serially diluted with N-free succinate-mineral medium, the process became N-limited. About 40% of randomly selected bacterial colonies grown on succinate agar medium were able to decompose CL-20. Based on 16S rDNA gene sequence and cell morphology, they were affiliated to Pseudomonas, Rhodococcus, Ochrobactrum, Mycobacterium and Ralstonia. In the pure culture of Pseudomonas sp. MS-P grown on the succinate-mineral N(+) medium, the degradation kinetics were first order with the same apparent kinetic constant throughout growth and decline phases of the batch culture. The observed kinetics agreed with the model that supposes co-metabolic transformation of CL-20 uncoupled from cell growth, which can be carried out by several constitutive cellular enzymes with wide substrate specificity. C1 Stevens Inst Technol, Dept Chem & Biol Chem, Hoboken, NJ 07030 USA. Stevens Inst Technol, Ctr Environm Syst, Hoboken, NJ 07030 USA. USA, RDECOM, ARDEC, Picatinny Arsenal, NJ 07806 USA. RP Panikov, NS (reprint author), Stevens Inst Technol, Dept Chem & Biol Chem, Castle Point Hudson, Hoboken, NJ 07030 USA. EM npanikov@stevens.edu NR 36 TC 12 Z9 14 U1 2 U2 14 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0923-9820 J9 BIODEGRADATION JI Biodegradation PD JUN PY 2007 VL 18 IS 3 BP 317 EP 332 DI 10.1007/s10532-006-9066-6 PG 16 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 159LW UT WOS:000245868400007 PM 17091356 ER PT J AU Doyle, R Grodowitz, M Smart, M Owens, C AF Doyle, Robert Grodowitz, Michael Smart, Michael Owens, Chetta TI Separate and interactive effects of competition and herbivory on the growth, expansion, and tuber formation of Hydrilla verticillata SO BIOLOGICAL CONTROL LA English DT Article DE competitive release; invasive species; Hydrellia pakistanae; Vallisneria americana ID HYDRELLIA-PAKISTANAE DIPTERA; VALLISNERIA-AMERICANA; BIOLOGICAL-CONTROL; PLANT COMPETITION; INSECT HERBIVORY; EPHYDRIDAE; HYDROCHARITACEAE; POPULATION; INVASION AB This study examined the interaction and main-effect impacts of herbivory by the leaf-mining fly Hydrellia pakistanae and plant competition from Vallisneria americana on the growth, expansion and tuber formation of Hydrilla verticillata in a 2 x 2 factorial design experiment. The study was conducted in 14,000-L tanks, over two growing seasons. Each tank represented a single experimental unit and contained 32 1-L pots. At the beginning of the experiment half of these were planted with H. verticillata while the other half were either left empty or planted with V americana (the competitor). H. pakistanae fly larvae (the herbivore) were added to tanks as appropriate. No significant interactions were identified between herbivory and competition on any parameter of H. verticillata growth analyzed (i.e., total tank biomass accumulation, total number of rooting stems, total tuber number, total tuber mass, and tuber size), indicating that the factors were operating independently and neither antagonism nor synergism was occurring. Both competition and herbivory impacted the growth of H. verticillata. H. verticillata plants grown in the presence of V. americana developed less total biomass, had fewer total basal stems, had fewer tubers and less tuber mass per tank, and produced significantly smaller tubers relative to control plants. Herbivory also suppressed H. verticillata biomass accumulation and tended to suppress the number and total mass of tubers produced in each tank. Both factors showed 30-40% reduction of total H. verticillata biomass, although the mechanism of impact was different. Competition suppressed expansion of H. verticillata into adjoining pots but had little impact on its growth in pots where it was originally planted. Herbivory resulted in a general suppression of growth of H. verticillata in all pots. Although herbivory significantly impacted H. verticillata biomass, it did not result in competitive release for V. americana under the current experimental conditions. We conclude that management activities that promote competition or herbivory will impact the growth and expansion of H. verticillata. Furthermore, since these factors operated independently.. the combined use of both factors should be beneficial for suppression of H. verticillata dominance. (c) 2007 Published by Elsevier Inc. C1 USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. USA, Engineer Res & Dev Ctr, Lewisville Aquat Ecosyst Res Facil, Lewisville, TX USA. Lewisville Aquat Ecosyst Res Facil, ASI, Lewisville, TX USA. RP Grodowitz, M (reprint author), USA, Engineer Res & Dev Ctr, Vicksburg, MS USA. EM Michael.J.Grodowitz@erdc.usace.army.mil NR 44 TC 19 Z9 21 U1 1 U2 11 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-9644 J9 BIOL CONTROL JI Biol. Control PD JUN PY 2007 VL 41 IS 3 BP 327 EP 338 DI 10.1016/j.biocontrol.2007.03.004 PG 12 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 178OF UT WOS:000247229300006 ER PT J AU Horsmon, JR Cao, CJ Khan, AS Gostomski, MV Valdes, JJ O'Connell, KP AF Horsmon, Jennifer R. Cao, Cheng J. Khan, Akbar S. Gostomski, Mark V. Valdes, James J. O'Connell, Kevin P. TI Real-time fluorogenic PCR assays for the detection of entA, the gene encoding staphylococcal enterotoxin A (vol 28, pg 823, 2006) SO BIOTECHNOLOGY LETTERS LA English DT Correction C1 USA, Edgewood Chem Biol Ctr, AMSRD ECB RT BM, Edgewood, MD 21010 USA. SAIC, Aberdeen Proving Ground, MD 21010 USA. USA, Ctr Hlth Promot & Prevent Med, Edgewood, MD 21010 USA. Def Threat Reduct Agcy, Ft Belvoir, VA 22060 USA. RP O'Connell, KP (reprint author), USA, Edgewood Chem Biol Ctr, AMSRD ECB RT BM, Aberdeen Proving Ground 5183, Edgewood, MD 21010 USA. EM kevin.oconnell1@us.army.mil NR 1 TC 0 Z9 0 U1 1 U2 3 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0141-5492 J9 BIOTECHNOL LETT JI Biotechnol. Lett. PD JUN PY 2007 VL 29 IS 6 BP 983 EP 984 DI 10.1007/s10529-007-9344-3 PG 2 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA 159MD UT WOS:000245869100023 ER PT J AU Shorr, AF Jackson, WL Weiss, BM Moores, LK AF Shorr, Andrew F. Jackson, William L. Weiss, Brendan M. Moores, Lisa K. TI Low-molecular weight heparin for deep vein thrombosis prophylaxis in hospitalized medical patients: results from a cost-effectiveness analysis SO BLOOD COAGULATION & FIBRINOLYSIS LA English DT Article DE cost; cost-effectiveness; deep vein thrombosis; low-molecular-weight heparin; prevention ID RECURRENT VENOUS THROMBOEMBOLISM; INTENSITY WARFARIN THERAPY; PLACEBO-CONTROLLED TRIAL; INDUCED THROMBOCYTOPENIA; UNFRACTIONATED HEPARIN; OUTPATIENT TREATMENT; ECONOMIC-EVALUATION; CRITICAL-CARE; MAJOR TRAUMA; LONG-TERM AB Multiple options exist for the prevention of deep vein thrombosis (DVT) in medical inpatients. We sought to determine the cost-effectiveness of low-molecular-weight heparin (LMWH) relative to unfractionated heparin (UFH) for DVT prevention in this setting. We conducted a cost-effectiveness analysis from the perspective of a third-party payer employing a decision model and literature-based estimates for inputs. In the base-case analysis, LMWH had little impact on the rate of DVT. Despite higher acquisition costs, however, LMWHs resulted in net savings. Routine use of LMWH saves approximately LIS$89 per patient. The lower rate of heparin-induced thrombocytopenia (HIT) with LMWH accounted for this differential. Univariate sensitivity analysis revealed the model was moderately sensitive to the odds ratio of HIT with LMWH and the cost of HIT. Multivariate sensitivity analysis confirmed the LMWH approach dominated financially. 'Worst-case' scenario modeling, where LMWH actually increased the risk for DVT, had little effect on the rate of HIT, and was substantially more costly than UFH, still demonstrated that LMWHs were economically superior. Monte-Carlo simulation indicated the 95% confidence interval around the estimate for savings with LMWH ranged from US$7 to US$373. We conclude that, despite their higher cost, LMWHs for thromboprophylaxis in medical patients result in savings. C1 Washington Hosp Ctr, Pulm & Crit Care Med Serv, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Crit Care Med Serv, Dept Surg, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Hematol Oncol Serv, Dept Med, Washington, DC 20307 USA. RP Shorr, AF (reprint author), Washington Hosp Ctr, Pulm & Crit Care Med Serv, 110 Irving St NW, Washington, DC 20010 USA. EM afshorr@dnamail.com NR 29 TC 20 Z9 20 U1 0 U2 3 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0957-5235 EI 1473-5733 J9 BLOOD COAGUL FIBRIN JI Blood Coagul. Fibrinolysis PD JUN PY 2007 VL 18 IS 4 BP 309 EP 316 DI 10.1097/MBC.0b013e328099af58 PG 8 WC Hematology SC Hematology GA 172HQ UT WOS:000246795200003 PM 17473570 ER PT J AU Nindl, BC AF Nindl, B. C. TI Exercise modulation of growth hormone isoforms: current knowledge and future directions for the exercise endocrinologist SO BRITISH JOURNAL OF SPORTS MEDICINE LA English DT Article ID RESISTANCE EXERCISE; HETEROGENEITY; RESPONSES; WOMEN AB Importance of growth hormone molecular heterogeneity as a partial mechanism for somatogenic adaptations to physical activity. C1 USA, Environm Med Res Inst, Mil Performance Div, Natick, MA USA. RP Nindl, BC (reprint author), USA, Environm Med Res Inst, Mil Performance Div, Natick, MA USA. EM bradley.nindl@na.amedd.army.mil NR 12 TC 14 Z9 15 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0306-3674 J9 BRIT J SPORT MED JI Br. J. Sports Med. PD JUN PY 2007 VL 41 IS 6 BP 346 EP 348 DI 10.1136/bjsm.2006.028951 PG 3 WC Sport Sciences SC Sport Sciences GA 171FI UT WOS:000246720100002 PM 17237119 ER PT J AU Devine, PJ Turco, MA Taylor, AJ AF Devine, Patrick J. Turco, Mark A. Taylor, Allen J. TI Design and rationale of the ARBITER 6 trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol)-6-HDL and LDL treatment strategies in atherosclerosis (HALTS) SO CARDIOVASCULAR DRUGS AND THERAPY LA English DT Article DE atherosclerosis; carotid intima-media thickness; extended-release niacin; ezetimibe; lipid lowering therapy ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; GROWTH EVALUATION STATIN; EXTENDED-RELEASE NIACIN; LIPID-LOWERING THERAPY; PRIMARY HYPERCHOLESTEROLEMIA; CARDIOVASCULAR-DISEASE; COLESTIPOL-NIACIN; WALL THICKNESS; CAROTID-ARTERY AB Background Recent evidence on the use of statin therapy indicates the potential for ultra-low levels of LDL-C to provide greater protection from recurrent coronary heart disease events. Guidelines for the treatment of lipid disorders were revised to indicate that an LDL-C treatment goal of 70 mg/dl was optional (NCEP ATPIII). In these same guidelines, low levels of HDL-C are also suggested but not specifically proscribed as a target of therapy. Recently ARBITER 2 (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 2) has provided the first evidence of the potential of raising HDL-C with extended release niacin when added to statin monotherapy in secondary prevention. However, whether this approach would be superior to a strategy in which lower concentrations of LDL-C are targeted is unknown. Materials and methods ARBITER 6-HALTS ( HDL and LDL Treatment Strategies) will be a randomized, parallel group, open-label study comparing HDL-C and LDL-C focused strategies of lipid treatments for their effects on atherosclerosis. Up to 400 subjects will be assigned to either intensified LDL-C lowering therapy with ezetimibe or HDL-C raising therapy with extended-release niacin. The primary endpoint is the mean change in the intima-media thickness of the common carotid artery after 14 months. Secondary endpoints include the change in lipid values and lipid subfractions, drug discontinuation due to adverse effects, change in quality of life, and a composite endpoint consisting of all major adverse cardiovascular events. Conclusion ARBITER 6-HALTS will guide clinicians on whether a lipid treatment strategy of raising HDL-C or further LDL-C reduction is superior in the secondary prevention of coronary heart disease. C1 Walter Reed Army Med Ctr, Serv Cardiol, Dept Med, Washington, DC 20307 USA. Washington Adventist Hosp, Ctr Cardiac & Vasc Res, Takoma Pk, MD USA. RP Devine, PJ (reprint author), Walter Reed Army Med Ctr, Serv Cardiol, Dept Med, 6900 Georgia Ave,NW,Bldg 2,Room 4A28, Washington, DC 20307 USA. EM patrick.devine@na.amedd.army.mil NR 23 TC 22 Z9 23 U1 0 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-3206 EI 1573-7241 J9 CARDIOVASC DRUG THER JI Cardiovasc. Drugs Ther. PD JUN PY 2007 VL 21 IS 3 BP 221 EP 225 DI 10.1007/s10557-007-6020-8 PG 5 WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy GA 171WE UT WOS:000246765300009 PM 17404825 ER PT J AU Blakely, JN Eskridge, MB Corron, NJ AF Blakely, Jonathan N. Eskridge, Michael B. Corron, Ned J. TI A simple Lorenz circuit and its radio frequency implementation SO CHAOS LA English DT Article ID CHAOS; OSCILLATORS; COMMUNICATION AB A remarkably simple electronic circuit design based on the chaotic Lorenz system is described. The circuit consists of just two active nonlinear elements (high-speed analog multipliers) and a few passive linear elements. Experimental implementations of the circuit exhibit the classic butterfly attractor and the hysteretic transition from steady state to chaos observed in the Lorenz equations. The simplicity of the circuit makes it suitable for radio frequency applications. The power spectrum of the observed oscillations displays a peak frequency as high as 930 kHz and significant power beyond 1 MHz. C1 US Army, Res Dev & Engn Command, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. RP Blakely, JN (reprint author), US Army, Res Dev & Engn Command, AMSRD AMR WS ST, Redstone Arsenal, AL 35898 USA. OI Blakely, Jonathan/0000-0002-9772-582X; Corron, Ned/0000-0002-3232-5024 NR 26 TC 8 Z9 8 U1 0 U2 4 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 1054-1500 J9 CHAOS JI Chaos PD JUN PY 2007 VL 17 IS 2 AR 023112 DI 10.1063/1.2723641 PG 5 WC Mathematics, Applied; Physics, Mathematical SC Mathematics; Physics GA 184FD UT WOS:000247625600012 PM 17614666 ER PT J AU Abadie, JM AF Abadie, J. M. TI Can the Roche Tina-quant hemoglobin A1c (HbA1c) immunoassay approach gold-standard accuracy for clinically elevated HbA1c in patients with a hemoglobinopathy? SO CLINICAL CHEMISTRY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Association-for-Clinical-Chemistry CY JUL 15-19, 2007 CL San Diego, CA SP Amer Assoc Clin Chem C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUN PY 2007 VL 53 IS 6 SU S MA A90 BP A29 EP A29 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 172ZJ UT WOS:000246843000091 ER PT J AU Dudley, TA Erwin, D Ewell, A AF Dudley, T. A. Erwin, D. Ewell, A. TI Clinical comparison of two commercially available lyme screening ELISA assays SO CLINICAL CHEMISTRY LA English DT Meeting Abstract CT 59th Annual Meeting of the American-Association-for-Clinical-Chemistry CY JUL 15-19, 2007 CL San Diego, CA SP Amer Assoc Clin Chem C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD JUN PY 2007 VL 53 IS 6 SU S MA C-121 BP A141 EP A141 PG 1 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 172ZJ UT WOS:000246843000447 ER PT J AU Taylor, KF Rafiee, B Tis, JE Inoue, N AF Taylor, Kenneth F. Rafiee, Bahman Tis, John E. Inoue, Nozumu TI Low-intensity pulsed ultrasound does not enhance distraction callus in a rabbit model SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID AGGRECAN GENE-EXPRESSION; RAT CHONDROCYTES; ILIZAROV METHOD; FRACTURE MODEL; BONE-GROWTH; IN-VITRO; OSTEOGENESIS; STIMULATION; MATURATION; CONSOLIDATION AB Low-intensity pulsed ultrasound has been reported to have a positive effect when applied during the consolidation phase of distraction osteogenesis and bone transportation, but the optimal application time has not been determined. We used a rabbit model to determine whether low-intensity pulsed ultrasound applied during the distraction and early consolidation phases of tibial lengthening would have a positive effect on regenerated bone formation. Radiographic analysis showed no differences in regenerated callus area or in percent of callus mineralization between treated and control tibias immediately after distraction or at 1, 2, or 3 weeks after distraction. Similarly, we observed no differences in structural stiffness or maximal torque to failure at 1.5 or 3 weeks after distraction. We detected no differences in bone mineral appositional rates or percent tissue composition measured histologically between groups. Our data do not support the application of low-intensity pulsed ultrasound to regenerated bone during distraction osteogenesis. C1 Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Johns Hopkins Univ, Sch Med, Dept Orthoped Surg, Orthopaed Biomech Lab, Baltimore, MD 21218 USA. RP Tis, JE (reprint author), Walter Reed Army Med Ctr, Dept Orthoped, Washington, DC 20307 USA. EM johjohn.tis@NA.amedd.us.army.mil NR 44 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUN PY 2007 IS 459 BP 237 EP 245 DI 10.1097/BLO.0b013e31803c75b4 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 176KZ UT WOS:000247085300039 PM 17545764 ER PT J AU Klemcke, HG Cortez, DS Cox, AB Ryan, KL AF Klemcke, Harold G. Cortez, Douglas S. Cox, Ashley B. Ryan, Kathy L. TI A novel swine model for evaluation of potential intravascular hemostatic agents SO COMPARATIVE MEDICINE LA English DT Article ID V LIVER-INJURIES; UNCONTROLLED HEMORRHAGIC-SHOCK; RECOMBINANT FACTOR VIIA; VON-WILLEBRAND-FACTOR; COMBAT CASUALTY CARE; BLEEDING-TIME; FIBRIN SEALANT; FLUID RESUSCITATION; ARTERIAL THROMBOSIS; BLOOD-LOSS AB Because uncontrolled hemorrhage is a leading cause of battlefield mortality, finding an intravenous treatment that could assist endogenous clotting mechanisms is a major mission for military researchers. Evaluation of potential intravenous hemostatic agents requires both in vitro and in vivo tests. For in vivo evaluation, we have developed a novel swine model in which 1) bleeding times (BT) and coagulation function could be ascertained after multiple doses of hemostatic drug administration and 2) a subsequent exsanguinating injury could be performed in the same animal, yielding screening information regarding the effects of drug pretreatment on blood loss and survival. Transection of small mesenteric arteries and veins allowed for multiple and reproducible BT measures that correlated with coagulation function. Subsequent excision of defined areas of the liver produced bleeding predominantly from small vessels (diameter, less than 2 mm) and parenchyma while resulting in 62% mortality without the use of either heparinization or aggressive fluid infusion. This swine model allows for multiple, repeatable BT measures in the same animal in experiments already involving laparotomy. Such a model is well suited for terminal studies to test effects of multiple doses of the same drug or multiple drugs on BT and allows for multiple, easily visualized measures that permit enhanced repeatability. The liver injury provides for numerous small vessel lesions that could be amenable to closure by coagulation. Therefore, drugs or mechanisms that enhance coagulation and concomitantly decrease blood loss and increase survival time may be accurately evaluated in this new model. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Klemcke, HG (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM Harold.klemcke@amedd.army.mil NR 60 TC 0 Z9 0 U1 0 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI MEMPHIS PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA SN 1532-0820 J9 COMPARATIVE MED JI Comparative Med. PD JUN PY 2007 VL 57 IS 3 BP 292 EP 297 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 180UJ UT WOS:000247391300008 PM 17605345 ER PT J AU Baylot, JT Bevins, TL AF Baylot, James T. Bevins, Tommy L. TI Effect of responding and failing structural components on the airblast pressures and loads on and inside of the structure SO COMPUTERS & STRUCTURES LA English DT Article; Proceedings Paper CT 4th MIT Conference on Computational Fluid and Solid Mechanics CY JUN 13-15, 2007 CL MIT, Cambridge, MA HO MIT DE fluid-structure interaction; finite element analysis; computational fluid dynamics; airblast; structure response; computational structural dynamics AB The presence of non-structural exterior walls can affect the loads on structural columns when high explosives detonate near that column. Numerical simulations and physical experiments were used to determine the effect of exterior (no wall and solid masonry wall) type on the loads on and response of exterior columns. Both the simulations and the experiments indicate that although the exterior wall fails very quickly, it still significantly affects the loads on the column and the airblast pressures entering the structure. (C) 2007 Elsevier Ltd. All rights reserved. C1 USA, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Baylot, JT (reprint author), USA, Engn Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM James.T.Baylot@erdc.usace.army.mil; Tommy.L.Bevins@erdc.usace.army.mil NR 72 TC 14 Z9 15 U1 2 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD JUN PY 2007 VL 85 IS 11-14 SI SI BP 891 EP 910 DI 10.1016/j.compstruc.2007.01.001 PG 20 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA 181GE UT WOS:000247424400023 ER PT J AU Martini, WZ Dubick, MA Wade, CE Holcomb, JB AF Martini, Wenjun Z. Dubick, Michael A. Wade, Charles E. Holcomb, John B. TI Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs SO CRITICAL CARE MEDICINE LA English DT Article DE trauma; fibrinogen; platelets; thromboelastography; thrombin generation ID BICARBONATE THERAPY; COAGULOPATHY; HYPOTHERMIA; HEMORRHAGE; SWINE; HEMOPHILIA; MECHANISM; LACTATE; INJURY; BLOOD AB Objective: To investigate the effect of tris-hydroxymethylaminomethane (THAM) pH neutralization on reversing coagulation abnormalities caused by acidosis. Design: Random and controlled study. Setting. Animal research facility and laboratory. Subjects. Yorkshire swine (n = 18). Interventions, Acidosis was induced in 12 pigs by infusing 0.2 M hydrochloric acid (HCl). When the target pH of 7.1 was achieved, the pigs were infused with either 0.3 M THAM to achieve pH of 7.4 (intervention group) or an equal volume of lactated Ringer's solution (acid control group). Measurements and Main Results: Blood samples were taken at baseline, 15 mins after reaching pH of 7.1, and 15 mins after THAM pH neutralization. Coagulation function was assessed by thrombin generation, prothrombin time, activated partial thromboplastin time, activated clotting time, and thromboelastography (maximum clot formation time [R+K], clotting rapidity [alpha], and clot strength [maximum amplitude]). An additional six pigs (sham group) were infused with THAM, and an equal volume of fluid as the 12 coagulopathic pigs was given to assess effects of THAM and hemodilution. Comparisons were made using a mixed model analysis of variance. No change in any indexes of coagulation was observed in sham pigs. Compared with baseline, acidosis of pH 7.1 decreased base excess from 6.6 +/- 0.5 mM to -12.4 +/- 0.5 mM; reduced fibrinogen levels to 72% +/- 2%, platelet counts to 53% +/- 3%, thrombin generation to 58% +/- 4%, alpha to 84% +/- 2%, and maximum amplitude to 75% +/- 3%; and prolonged prothrombin time to 113% +/- 2%, partial thromboplastin time to 122% +/- 4%, activated clotting time to 124% +/- 3%, and R + K to 119% +/- 3% (all p < .05). THAM infusion corrected pH to 7.40 +/- 0.02 and base excess to 2.6 +/- 0.9 mM (p < .05). However, there were no differences in thrombin generation, prothrombin time, partial thromboplastin time, activated clotting time, R + K, alpha, or maximum amplitude between the groups with or without pH correction. Conclusions: Acidosis impaired coagulation by depleting clotting factors, inhibiting thrombin generation, and affecting clot strength and stability. THAM corrected acid-base deficit but did not acutely reverse the coagulation abnormalities in the model. C1 USA, Inst Surg Res, Houston, TX USA. RP Martini, WZ (reprint author), USA, Inst Surg Res, Houston, TX USA. EM wenjun.martini@amedd.army.mil NR 26 TC 40 Z9 49 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 2007 VL 35 IS 6 BP 1568 EP 1574 DI 10.1097/01.CCM.0000266682.74602.6A PG 7 WC Critical Care Medicine SC General & Internal Medicine GA 170QO UT WOS:000246679200016 PM 17452929 ER PT J AU Lewis, FS Smith, LJ AF Lewis, Felisa S. Smith, Laurie J. TI What's eating you? Bees, part 1: Characteristics, reactions, and management SO CUTIS LA English DT Article ID ALLERGIC REACTIONS; AFRICANIZED BEES; INSECT STINGS; UNITED-STATES; ANAPHYLAXIS; HYMENOPTERA; BITES; VENOM; HEALTH AB Bee stings are common in the United States. We review the characteristics of bumblebees, honeybees, and Africanized honeybees; the types and pathophysiology of sting reactions; and the medical management and prevention of bee stings. In part 2 of this series, we will discuss the use of venom immunotherapy, the diagnosis of systemic mastocytosis that initially presents as anaphylaxis, and the efficacy of immunotherapy in patients with mastocytosis. C1 Walter Reed Army Med Ctr, Dept Allergy & Immunol, Washington, DC 20307 USA. RP Lewis, FS (reprint author), 231 Little Quarry Rd, Gaithersburg, MD 20878 USA. EM felisa.lewis@na.amedd.army.mil NR 44 TC 1 Z9 1 U1 0 U2 1 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 2007 VL 79 IS 6 BP 439 EP 444 PG 6 WC Dermatology SC Dermatology GA 185HK UT WOS:000247701800005 PM 17713146 ER PT J AU Lackey, JN Xia, Y Cho, S Sperling, LC AF Lackey, Jeffrey N. Xia, Yang Cho, Sunghun Sperling, Leonard C. TI Cutaneous lymphoid hyperplasia: A case report and brief review of the literature SO CUTIS LA English DT Review ID MARGINAL ZONE LYMPHOMA; B-CELL LYMPHOMA; LYMPHOCYTOMA CUTIS; PSEUDOLYMPHOMA; INJECTIONS; THERAPY AB Cutaneous lymphoid hyperplasia (CLH) is considered a benign lymphoid reactive process that results from various antigenic stimuli and may have potential for progression to overt lymphoma. CLH lesions may closely resemble lymphoma both clinically and histologically. We present a case of a 54-year-old woman who spontaneously developed lesions of unknown cause consistent with CLH. We also review the literature and discuss the etiology, clinical features, diagnosis, and management of CLH. C1 Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. RP Lackey, JN (reprint author), Walter Reed Army Med Ctr, Dermatol Serv, Washington, DC 20307 USA. NR 25 TC 4 Z9 4 U1 0 U2 0 PU QUADRANT HEALTHCOM INC PI PARSIPPANY PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA SN 0011-4162 J9 CUTIS JI Cutis PD JUN PY 2007 VL 79 IS 6 BP 445 EP 448 PG 4 WC Dermatology SC Dermatology GA 185HK UT WOS:000247701800006 PM 17713147 ER PT J AU Sjogren, MH Sjogren, R Lyons, MF Ryan, M Santoro, J Smith, C Reddy, KR Bonkovsky, H Huntley, B Faris-Young, S AF Sjogren, Maria H. Sjogren, Robert, Jr. Lyons, Michael F. Ryan, Michael Santoro, John Smith, Coleman Reddy, K. Rajender Bonkovsky, Herbert Huntley, Brooke Faris-Young, Sima TI Antiviral response of HCV genotype 1 to consensus interferon and ribavirin versus pegylated interferon and ribavirin SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE viral hepatitis; viral load; depression; quality of life; African-American; interferon alfacon-1 ID CHRONIC HEPATITIS-C; UNITED-STATES; PEGINTERFERON ALPHA-2B; VIRUS-INFECTION; PLUS RIBAVIRIN; DEPRESSION; MANAGEMENT; THERAPY; TRIAL; SCALE AB Achieving an antiviral response at a reasonable cost is a challenge in the treatment of patients with chronic hepatitis C. A previous study indicated that consensus interferon with ribavirin had promising activity against hepatitis C virus (HCV) genotype 1. The objective of this study was to determine the virologic response with consensus interferon or pegylated interferon alpha-2b plus weight-ribavirin in patients chronically infected with HCV genotype 1. Intention-to-treat analysis showed response in 37% and 41% of subjects treated with consensus interferon/ribavirin or pegylated interferon/ribavirin, respectively, with response rates of 42% and 44% observed in analysis of the per-protocol population, not a significant difference. Tolerability of the two treatment regimens was similar. In conclusion, both treatment regimens were safe and gave a similar antiviral response. It is possible that if consensus interferon is administered daily rather than three times weekly, eradication of HCV could be achieved in a larger proportion of patients infected with HCV genotype 1. C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. Kaiser Permanente, Falls Church, VA USA. Digest & Liver Dis Specialists, Norfolk, VA USA. Minnesota Gastroenterol, St Paul, MN USA. Minnesota Gastroenterol, Philadelphia, PA USA. UPenn GI Res, Philadelphia, PA USA. UConn Hlth Ctr, Farmington, CT USA. Intermune Inc, Brisbane, CA USA. RP Sjogren, MH (reprint author), Walter Reed Army Med Ctr, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM maria.sjogren@na.amedd.army.mil NR 27 TC 21 Z9 22 U1 1 U2 1 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD JUN PY 2007 VL 52 IS 6 BP 1540 EP 1547 DI 10.1007/s10620-007-9757-9 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA 169SL UT WOS:000246611900028 PM 17406822 ER PT J AU Su, D Santare, MH Gazonas, GA AF Su, Dan Santare, Michael H. Gazonas, George A. TI The effect of crack face contact on the anisotropic effective moduli of microcrack damaged media SO ENGINEERING FRACTURE MECHANICS LA English DT Article DE anisotropic damage; effective moduli; generalized self-consistent method; microcracks ID INTEGRAL-EQUATION METHOD; BOUNDARY-ELEMENT; BRITTLE SOLIDS; FRACTURED ROCK; ELASTIC-MODULI; INCLUSION; BODIES; MODEL; COMPOSITES; MECHANICS AB The generalized self-consistent method (GSCM) in conjunction with a computational finite element method is used to calculate the anisotropic effective moduli of a medium containing damage consisting of microcracks with an arbitrary degree of alignment. Since cracks respond differently under different external loads, the moduli of the medium subjected to tension, compression and an initially stress-free state are evaluated and shown to be significantly different, which will further affect the wave speed inside the damaged media. There are four independent material moduli for a 2-D plane stress orthotropic medium in tension or compression, and seven independent material moduli for a 2-D plane stress orthotropic cracked medium, which is initially stress free. When friction exists, it further changes the effective moduli. Numerical methods are used to take into account crack face contact and friction. The wave slowness profiles for microcrack damaged media are plotted using the predicted effective material moduli. (C) 2006 Elsevier Ltd. All rights reserved. C1 Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. Univ Delaware, Ctr Composite Mat, Newark, DE 19716 USA. USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Santare, MH (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA. EM santare@me.udel.edu RI Santare, Michael/B-1725-2008; OI Gazonas, George/0000-0002-2715-016X NR 38 TC 7 Z9 7 U1 0 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0013-7944 J9 ENG FRACT MECH JI Eng. Fract. Mech. PD JUN PY 2007 VL 74 IS 9 BP 1436 EP 1455 DI 10.1016/j.engfracmech.2006.08.015 PG 20 WC Mechanics SC Mechanics GA 166UV UT WOS:000246407000004 ER PT J AU Lassman, TC AF Lassman, Thomas C. TI 80 years of research at the Philips Natuurkundig Laboratorium, 1914-1994. SO ENTERPRISE & SOCIETY LA English DT Book Review C1 USA, Ctr Mil Hist, Washington, DC 20310 USA. RP Lassman, TC (reprint author), USA, Ctr Mil Hist, Washington, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1467-2227 J9 ENTERP SOC JI Enterp. Soc PD JUN PY 2007 VL 8 IS 2 BP 441 EP 444 DI 10.1093/es/khm038 PG 4 WC Business; History Of Social Sciences SC Business & Economics; Social Sciences - Other Topics GA 182VK UT WOS:000247531900017 ER PT J AU Tischler, M Garcia, M Peters-Lidard, C Moran, MS Miller, S Thoma, D Kumar, S Geiger, J AF Tischler, M. Garcia, M. Peters-Lidard, C. Moran, M. S. Miller, S. Thoma, D. Kumar, S. Geiger, J. TI A GIS framework for surface-layer soil moisture estimation combining satellite radar measurements and land surface modeling with soil physical property estimation SO ENVIRONMENTAL MODELLING & SOFTWARE LA English DT Article DE GIS; ARMS; model integration; soil moisture; land information system; parameter estimation ID SOUTHERN GREAT-PLAINS; IMPROVED CALIBRATION; HYDROLOGIC-MODELS; MONSOON 90; MICROWAVE; INFORMATION; SYSTEM; SAR; MANAGEMENT; WATER AB A GIS framework, the Army Remote Moisture System (ARMS), has been developed to link the Land Information System (LIS), a high performance land surface modeling and data assimilation system, with remotely sensed measurements of soil moisture to provide a high resolution estimation of soil moisture in the near surface. ARMS uses available soil (soil texture, porosity, K-sat), land cover (vegetation type, LAI, Fraction of Greenness), and atmospheric data (Albedo) in standardized vector and raster GIS data formats at multiple scales, in addition to climatological forcing data and precipitation. PEST (Parameter EStimation Tool) was integrated into the process to optimize soil porosity and saturated hydraulic conductivity (A(sat)), using the remotely sensed measurements, in order to provide a more accurate estimate of the soil moisture. The modeling process is controlled by the user through a graphical interface developed as part of the ArcMap component of ESRI ArcGIS. Published by Elsevier Ltd. C1 USDA ARS, Walnut Gulch Expt Watershed, SW Watershed Res Ctr, Tucson, AZ 85719 USA. Univ Wyoming, Dept Renewable Resources, Laramie, WY 82071 USA. NASA, Goddard Space Flight Ctr, Univ Maryland Baltimore Cty, Greenbelt, MD 20771 USA. USA, Corps Engineers, Engn Res & Dev Ctr, Topog Engn Ctr, Alexandria, VA 22312 USA. RP Moran, MS (reprint author), USDA ARS, Walnut Gulch Expt Watershed, SW Watershed Res Ctr, 2000 E Allen Rd, Tucson, AZ 85719 USA. EM michael.a.tischler@erdc.usace.army.mil; smoran@tucson.ars.ag.gov RI Peters-Lidard, Christa/E-1429-2012; Garcia, Matthew/K-9286-2013; Kumar, Sujay/B-8142-2015 OI Peters-Lidard, Christa/0000-0003-1255-2876; Garcia, Matthew/0000-0002-9637-4204; NR 45 TC 16 Z9 16 U1 2 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 1364-8152 J9 ENVIRON MODELL SOFTW JI Environ. Modell. Softw. PD JUN PY 2007 VL 22 IS 6 BP 891 EP 898 DI 10.1016/j.envsoft.2006.05.022 PG 8 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Sciences SC Computer Science; Engineering; Environmental Sciences & Ecology GA 141SJ UT WOS:000244598700012 ER PT J AU Johnson, MS Suski, J Bazar, MA AF Johnson, Mark S. Suski, Jamie Bazar, Matthew A. TI Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4-dinitrotoluene SO ENVIRONMENTAL POLLUTION LA English DT Article; Proceedings Paper CT 22nd IUFRO World Forestry Congress CY AUG 08-13, 2005 CL Brisbane, AUSTRALIA DE amphibian; 2,4-DNT; salamander; toxicity; soil ID TERRESTRIAL SALAMANDER; REPRODUCTIVE TOXICITY; AMBYSTOMA-TIGRINUM; 2,4,6-TRINITROTOLUENE; DINITROTOLUENE; EXPLOSIVES; ABSORPTION; DECLINES; RAT AB Dinitrotoluenes are used as propellants and in explosives by the military and as such have been found at relatively high concentrations in the soil. To determine whether concentrations of 2,.4-dinitrotoluene (2,4-DNT) in soil are toxic to amphibians, 100 red-backed salamanders (Plethodon cinereus) were exposed to either 1500, 800, 200, 75 or 0 mg 2,4-DNT/kg soil for 28 days and evaluated for indicators of toxicity. Concentrations of 2,4-DNT were less than targets and varied with time. Most salamanders exposed to concentrations exceeding 1050 mg/kg died or were moribund within the first week. Salamanders exposed to soil concentrations exceeding 345 mg/kg lost >6% of their body mass though no mortality occurred. Overt effects included a reduction in feed consumption and an increase in bucco-pharyngeal oscillations in salamanders. These results suggest that only high soil concentrations of 2,4-DNT have the potential to cause overtly toxic effects in terrestrial salamanders. (c) 2006 Elsevier Ltd. All rights reserved. C1 USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, Aberdeen Proving Ground, MD 21010 USA. RP Johnson, MS (reprint author), USA, Ctr Hlth Promot & Prevent Med, Hlth Effects Res Program, 5158 Blackhawk Rd,ATTN MCHB-TS-THE, Aberdeen Proving Ground, MD 21010 USA. EM mark.s.johnson@us.army.mil NR 37 TC 3 Z9 3 U1 1 U2 4 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0269-7491 J9 ENVIRON POLLUT JI Environ. Pollut. PD JUN PY 2007 VL 147 IS 3 BP 604 EP 608 DI 10.1016/j.envpol.2006.10.007 PG 5 WC Environmental Sciences SC Environmental Sciences & Ecology GA 174DS UT WOS:000246922000020 PM 17137690 ER PT J AU Wallace, RF Kriebel, D Punnett, L Wegman, DH Amoroso, PJ AF Wallace, Robert F. Kriebel, David Punnett, Laura Wegman, David H. Amoroso, Paul J. TI Prior heat illness hospitalization and risk of early death SO ENVIRONMENTAL RESEARCH LA English DT Article DE epidemiology; retrospective cohort; mortality; heat illness; heat stroke ID CARDIOVASCULAR-DISEASES; STROKE; WOMEN; MEN AB Previous evidence suggests that severe heat illness may cause permanent acute damage to the heart, kidneys, and liver, which may possibly lead to chronic and even fatal disorders. We investigated whether individuals who had been hospitalized for severe heat illness were at increased risk of cause-specific and total mortality. A cohort mortality study was conducted of male and female US Army,personnel hospitalized for heat illness (HI) from 1971 to 2000 using appendicitis (APX) as the reference. Hospitalization records were acquired from the Total Army Injury and Health Outcomes Database (TAIHOD) for 3971 cases of HI and 17,233 APX reference cases. Subject vital status was established through the National Death Index. HI cases had a 40% increased risk of all-cause mortality compared to APX cases. Further examining cause-specific deaths, male cases of HI were at an increased rate of death from cardiovascular disease (CVD) (rate ratio (RR) - 1.71, 95% confidence interval (CI): 1.01, 2.89) and ischemic heart disease (IHD) (RR - 2.23, 95% CI: 1.02, 4.90) compared to APX reference cases. Our findings provide preliminary evidence for increased risk of mortality among those who have experienced prior hospitalization for heat illness. (C) 2007 Elsevier Inc. All rights reserved. C1 USA, Mil Performance Div, Environm Med Res Inst, Natick, MA 01760 USA. Univ Massachusetts, Sch Hlth & Environm, Dept Work Environm, Lowell, MA USA. RP Wallace, RF (reprint author), USA, Mil Performance Div, Environm Med Res Inst, 42 Kansas St, Natick, MA 01760 USA. EM robert.wallace@na.amedd.army.mil NR 24 TC 19 Z9 23 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD JUN PY 2007 VL 104 IS 2 BP 290 EP 295 DI 10.1016/j.envres.2007.01.003 PG 6 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA 176CP UT WOS:000247060700012 PM 17306249 ER PT J AU Vindigni, SM Srijan, A Wongstitwilairoong, B Marcus, R Meek, J Riley, PL Mason, C AF Vindigni, Stephen M. Srijan, Apichai Wongstitwilairoong, Boonchai Marcus, Ruthanne Meek, James Riley, Patricia L. Mason, Carl TI Prevalence of foodborne microorganisms in retail foods in Thailand SO FOODBORNE PATHOGENS AND DISEASE LA English DT Article ID CAMPYLOBACTER-JEJUNI; ARCOBACTER-BUTZLERI; THERMOPHILIC CAMPYLOBACTER; ANTIMICROBIAL RESISTANCE; SALMONELLA-ENTERITIDIS; ESCHERICHIA-COLI; ANIMAL ORIGIN; SPP.; RAW; SURVEILLANCE AB Worldwide, foodborne illness is often associated with consumption of meats and poultry products sold at retail markets. A cross-sectional retail food study was conducted in Bangkok, Thailand to assess the prevalence of bacterial pathogens on retail food samples. Raw chicken, beef, pork, and chicken eggs were purchased from fresh markets and supermarkets and tested for Salmonella spp., Campylobacter spp., Arcobacter spp., and Enterococcus spp. Suspect bacterial pathogens were isolated by differential culture and Salmonella species were serotyped. A total of 200 samples were collected from 50 markets between May and August 2003. Of the 200 samples tested, 121 (61%) were positive for at least one Salmonella spp. serogroup. A total of 175 Salmonella spp. were isolated. The most common serotype was Salmonella Anatum, followed by S. Corvallis and S. Derby. Campylobacter spp. were found in 31 (15.5%) of 200 samples. C. jejuni was isolated from 15% of fresh market chicken samples and 35% of supermarket chicken samples. Arcobacter spp. were isolated from 42 (21%) samples; fresh market chicken had significantly higher A. butzleri contamination than supermarket chicken. The presence of Enterococcus spp., an indication of fecal contamination, was detected in 188 (94%) samples, including 100% of the beef and pork sources. Few studies have examined retail food contamination in Thailand. In particular, the high prevalence of samples with Arcobacter spp. warrants further study to determine pathogenicity. C1 Yale Univ, Sch Epidemiol & Publ Hlth, New Haven, CT USA. USA Med Component, Armed Forces Res Inst Med Sci, Bangkok, Thailand. Connecticut Emerging Infect Program, New Haven, CT USA. Ctr Dis Control & Prevent, Coordinating Off Global Hlth, Atlanta, GA USA. RP Vindigni, SM (reprint author), 1600 Clifton Rd,MS E-28, Atlanta, GA 30333 USA. EM stephen.vindigni@gmail.com RI Valle, Ruben/A-7512-2013; OI MASON, CARL/0000-0002-3676-2811 NR 36 TC 39 Z9 40 U1 1 U2 9 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1535-3141 J9 FOODBORNE PATHOG DIS JI Foodborne Pathog. Dis. PD SUM PY 2007 VL 4 IS 2 BP 208 EP 215 DI 10.1089/fpd.2006.0077 PG 8 WC Food Science & Technology SC Food Science & Technology GA 185VS UT WOS:000247739100009 PM 17600488 ER PT J AU Das, R Dhokalia, A Huang, Z Hammamieh, R Chakraborty, N Linder, LE Jett, M AF Das, R. Dhokalia, A. Huang, Z. Hammamieh, R. Chakraborty, N. Linder, L. E. Jett, M. TI Study of proinflammatory responses induced by Yersinia pestis in human monocytes using cDNA arrays SO GENES AND IMMUNITY LA English DT Article DE plague; genomics; microarray ID NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-C; EPITHELIAL-CELLS; PERITONEAL-MACROPHAGES; OUTER PROTEINS; IMMUNE CELLS; IN-VITRO; KAPPA-B; THROMBOMODULIN; ENTEROCOLITICA AB Yersinia pestis, the causative agent of plague, is known to develop strategies to overcome the host immune mechanisms and survive in the host. The molecular changes induced by Y. pestis in the host are not well delineated. Here, we examined the early events triggered after the intracellular infection of Y. pestis in human monocytes and lymphocytes by analyzing the host transcriptional profiles using cDNA arrays. We found that sets of genes that, especially at early time periods, were highly upregulated in monocytes alone when compared with a mixed culture of lymphocytes and monocytes. Gene expression responses revealed genes coding for cytokines, chemokines, transcription factors, inflammatory and apoptosis-related genes. Protein levels were measured, and real-time polymerase chain reaction was used to validate the microarray results. Our data suggest that intracellular infection of human monocytes with Y. pestis results in a strong inflammatory response at early time periods and a downregulation of genes such as thromobomodulin, which may play a role in coagulation, resulting in disseminated intravascular coagulation, a primary cause of death in plague infected hosts. We provide evidence that genomic analysis can provide a solid foundation to mechanistic insights to explain some of the symptoms induced by Y. pestis. C1 Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, Silver Spring, MD 20910 USA. Walter Reed Army Inst Res, Dept Bacterial Dis, Silver Spring, MD 20910 USA. RP Jett, M (reprint author), Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM marti.jett@us.army.mil NR 45 TC 11 Z9 11 U1 0 U2 2 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1466-4879 J9 GENES IMMUN JI Genes Immun. PD JUN PY 2007 VL 8 IS 4 BP 308 EP 319 DI 10.1038/sj.gene.6364389 PG 12 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA 176WP UT WOS:000247115900005 PM 17429414 ER PT J AU Clausen, J Wessling, E Chirgwin, B AF Clausen, Jay Wessling, Elizabeth Chirgwin, Brad TI Energetic compound false positives in ground water profile samples SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article AB The analytical procedure U.S. EPA SW-846 method 8330 is the predominant technique used for analysis of energetic compounds in water and soil. The basis for compound identification is nonspecific and for some complex samples may yield false-positive results for energetic compounds. Suspended particulates and drilling fluids are potential interferents introduced to ground water profile samples. Profile samples-had a higher frequency of false positives relative to monitoring well samples. Additionally, the false-positive frequency was lower in samples where no lubricants or greases were used during drilling and sampling. Protocol refinements, the inclusion of photodiode array (PDA) spectral analysis, visual inspection of chromatograms and PDA spectra, and careful manual data evaluation have reduced false-positive detections. A project team investigating ground water with the potential for energetic compounds must have extensive experience with method 8330, knowledge of how to use PDA analysis, and experience in interpreting chromatograms and PDA spectra for the target compounds. C1 USA Corps Engineers, ERDC CRREL, Hanover, NH 03755 USA. MECX, Aurora, CO 80014 USA. Severn Trent Labs Inc, Colchester, VT 05446 USA. RP Clausen, J (reprint author), USA Corps Engineers, ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA. NR 11 TC 1 Z9 1 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD SUM PY 2007 VL 27 IS 3 BP 90 EP 101 DI 10.1111/j.1745-6592.2007.00154.x PG 12 WC Water Resources SC Water Resources GA 205ES UT WOS:000249097400007 ER PT J AU Dainty, LA Risinger, JI Morrison, C Chandramouli, GVR Bidus, MA Zahn, C Rose, GS Fowler, J Berchuck, A Maxwell, GL AF Dainty, Louis A. Risinger, John I. Morrison, Carl Chandramouli, G. V. R. Bidus, Michael A. Zahn, Chris Rose, G. Scott Fowler, Jeff Berchuck, Andrew Maxwell, G. Larry TI Overexpression of folate binding protein and mesothelin are associated with uterine serous carcinoma SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the Society-of-Gynecologic-Oncologists CY MAR 19-23, 2005 CL Miami Beach, FL SP Soc Gynecol Oncologists DE folate binding protein; papillary serous; gynecologic tumors ID GENE-EXPRESSION PROFILES; HUMAN OVARIAN-CARCINOMA; TISSUE MICROARRAY ANALYSIS; DIFFERENT HISTOLOGIC TYPES; ENDOMETRIAL CANCER; ANTITUMOR-ACTIVITY; IN-VITRO; RECEPTOR; ANTIGEN; ALPHA AB Purpose. Folate receptor alpha (FOLR1) is a membrane bound receptor involved in the transport of folate as well as other regulatory cellular processes. The purpose of this study was to examine the expression of FOLR1 in uterine cancers and to identify changes in gene expression that are associated with overexpression of FOLR1. Experimental design. Fifty-eight frozen uterine cancer specimens were stained for FOLR1 using immunohistochemistry and results were correlated with transcript expression noted on quantitative PCR. Total RNA from 16 cases of uterine serous carcinoma (USC) was analyzed for gene expression using the Affymetrix HG-U133A and HG-U133B GeneChip set. USCs overexpressing FOLR1 were compared to cancers with an absence of FOLR1 using binary comparison and template matching of data was used to identify genes that correlate with FOLR1 expression. Selected targets from this analysis were evaluated by quantitative PCR as well as in an independent set of USC represented in quadruplicate on a tissue microarray (TMA). Results. Overexpression of FOLR1 was observed in 11/16 (69%) of USC and 0/10 normal endometrium cases using frozen tissue specimens. Binary comparison between FOLR1 positive and negative cases identified 121 genes altered by 2-fold at p < 0.01 of which 45 are well correlated with FOLR1 expression pattern. Using quantitative PCR, both mesothelin (MSLN) and PTGS1 (COX1) were significantly increased in FOLR1 overexpressing tumors (p = 0.014 and p = 0.006 respectively). TMA confirmed that overexpression of FOLR1 and MSLN respectively occurred in 23/48 (48%) and 17/54 (32%) of pure USC. Conclusion. Both FOLR1 and MSLN are cell surface targets that are co-expressed at high levels in USC and are appealing targets for biologic therapy. (c) 2007 Published by Elsevier Inc. C1 Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20307 USA. Walter Reed Army Med Ctr, US Mil Canc Inst, Washington, DC 20307 USA. NCI, Lab Biosyst & Canc, Canc Res Ctr, Bethesda, MD 20892 USA. Mem Hlth Univ, Med Ctr, Dept Lab Oncol Res, Curtis & Elizabeth Anderson Canc Inst, Savannah, GA 31404 USA. Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA. Ohio State Univ, Div Gynecol Oncol, James Canc Ctr, Columbus, OH 43210 USA. Duke Univ, Med Ctr, Durham, NC 27110 USA. RP Maxwell, GL (reprint author), Walter Reed Army Med Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM george.maxwell@na.amedd.army.mil NR 36 TC 44 Z9 48 U1 0 U2 4 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN PY 2007 VL 105 IS 3 BP 563 EP 570 DI 10.1016/j.ygyno.2006.10.063 PG 8 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 172PG UT WOS:000246815700002 PM 17400285 ER PT J AU Leath, CA Huh, WK Hyde, J Cohn, DE Resnick, KE Taylor, NP Powell, MA Mutch, DG Bradley, WH Geller, MA Argenta, PA Gold, MA AF Leath, Charles A., III Huh, Warner K. Hyde, Johnny, Jr. Cohn, David E. Resnick, Kimberly E. Taylor, Nicholas P. Powell, Matthew A. Mutch, David G. Bradley, William H. Geller, Melissa A. Argenta, Peter A. Gold, Michael A. TI A multi-institutional review of outcomes of endometrial stromal sarcoma SO GYNECOLOGIC ONCOLOGY LA English DT Article; Proceedings Paper CT 36th Annual Meeting of the Society-of-Gynecologic-Oncologists CY MAR 19-23, 2005 CL Miami Beach, FL SP Soc Gynecol Oncologists DE endometrial stromal sarcoma; low-grade endometrial stromal sarcoma; high-grade endometrial stromal sarcoma; multi-institutional study; outcomes ID GYNECOLOGIC-ONCOLOGY-GROUP; LYMPH-NODE METASTASES; UTERINE SARCOMAS; TUMORS; UTERUS; RECURRENCE; SURVIVAL; CYCLOPHOSPHAMIDE; DETERMINANTS; IFOSFAMIDE AB Objective. To compare the clinical behavior and outcomes of low- and high-grade endometrial stromal sarcomas (LGESS and HGESS), respectively. Methods. Patients with endometrial stromal sarcoma from five different institutions were identified and reviewed for clinicopathologic variables, surgical management and outcomes. Statistical calculations including Chi-square, t-test and survival using the Kaplan-Meier method with the log rank test were performed. Results. One hundred and five patients were identified with 72 having LGESS, 31 with HGESS and 2 having unclassified tumors. The mean age was 50 years for patients with LGESS and 64 years for those with HGESS (p < 0.0001). In patients with LGESS, 68% (49 patients) had disease confined to the uterine corpus or cervix compared to 39% (12 patients) in HGESS (p=0.002). The median overall survival was 53 months for HGESS and had not yet been reached in LGESS with 87.8% alive at 80 months (p < 0.0001). In HGESS patients with extrauterine disease, the presence of residual disease greater than 2 cut had a significant effect on median survival. Median survival was 52 months for those who underwent optimal cytoreduction versus 2 months for those with suboptimal residual disease (p=0.007). The impact of cytoreduction was not seen in LGESS patients with extrauterine disease with 82.1% alive at 78 months. Conclusions. Low-grade and high-grade endometrial stromal sarcomas represent two distinct clinical entities and should be treated as such. Survival in patients with high-grade tumors appears to be related to amount of residual disease at the completion of initial surgery and would suggest the need for aggressive cytoreduction. The role of surgical staging and optimal adjuvant therapy remains unclear. (c) 2007 Elsevier Inc. All rights reserved. C1 Univ Alabama, Dept Obstet, Div Gynecol Oncol, Birmingham, AL USA. Univ Alabama, Dept Gynecol, Div Gynecol Oncol, Birmingham, AL USA. Univ Oklahoma, Hlth Sci Ctr, Dept Obstet, Div Gynecol Oncol, Oklahoma City, OK USA. Univ Oklahoma, Hlth Sci Ctr, Dept Gynecol, Div Gynecol Oncol, Oklahoma City, OK USA. Ohio State Univ, Dept Obstet, Div Gynecol Oncol, Columbus, OH 43210 USA. Ohio State Univ, Dept Gynecol, Div Gynecol Oncol, Columbus, OH 43210 USA. Washington Univ, Sch Med, Dept Obstet, Div Gynecol Oncol, St Louis, MO USA. Washington Univ, Sch Med, Dept Gynecol, Div Gynecol Oncol, St Louis, MO USA. Univ Minnesota, Dept Obstet, Div Gynecol Oncol, Minneapolis, MN USA. Univ Minnesota, Dept Gynecol, Div Gynecol Oncol, Minneapolis, MN USA. RP Leath, CA (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM charles.leath@amedd.army.mil OI Leath III, Charles/0000-0002-4034-6845 NR 30 TC 83 Z9 88 U1 0 U2 3 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN PY 2007 VL 105 IS 3 BP 630 EP 634 DI 10.1016/j.ygyno.2007.01.031 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 172PG UT WOS:000246815700012 PM 17320937 ER PT J AU Moroney, JW Zahn, CM Heaton, RB Crothers, B Kendall, BS Elkas, JC AF Moroney, John W. Zahn, Christopher M. Heaton, Robert B. Crothers, Barbara Kendall, Brian S. Elkas, John C. TI Normal endometrial cells in liquid-based cervical cytology specimens in women aged 40 or older SO GYNECOLOGIC ONCOLOGY LA English DT Article DE normal endometrial cells; uterine cancer; endometrial hyperplasia; papanicolaou smear; liquid based cytology; Thin Prep ID HORMONE REPLACEMENT THERAPY; 2001 BETHESDA SYSTEM; POSTMENOPAUSAL WOMEN; PAPANICOLAOU SMEARS; CERVICOVAGINAL SMEARS; CLINICAL-SIGNIFICANCE; ADENOCARCINOMA; CLASSIFICATION; PRECURSORS; CARCINOMA AB Objective. The 2001 Bethesda System consensus statement directs the reporting of endometrial cells on cervical cytologic preparations in women aged 40 years or older. Our objective was to assess the significance of endometrial cells on cervical liquid-based cytology (LBC) specimens in this population. Methods. The population included women aged 40 years or older in whom endometrial cells were identified in otherwise normal LBC specimens from December 2001 through June 2005, and who subsequently underwent endometrial sampling within a 12-month period. Patient age, menopausal status, hormonal use, the presence or absence of co-incident symptoms and endometrial sampling results were recorded. Results. Endometrial cells were identified on LBC specimens in 2494 women during the study period, for an incidence of 0.4%. Of these, 370 women underwent endometrial sampling within 12 months of the incident LBC preparation and met inclusion criteria. In asymptomatic premenopausal women, sampled solely due to the presence of endometrial cells, 2.1% were identified with significant endometrial pathology, compared to 2.6% of symptomatic premenopausal women. In menopausal women, only those with symptoms (mainly bleeding) had significant pathology on subsequent sampling (25%); none of the asymptomatic menopausal women were found to have hyperplasia or carcinoma. No significant differences were identified in premenopausal women according to the time of sampling during the menstrual cycle or use of oral contraceptives. Conclusion. Endometrial cells on LBC preparations, even in the absence of symptoms in premenopausal women aged 40 years or older, are associated with significant uterine pathology. (c) 2007 Published by Elsevier Inc. C1 Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77230 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Natl Naval Med Ctr, Bethesda, MD USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. No Virginia Pelv Surg Associates, Annandale, VA USA. RP Moroney, JW (reprint author), Univ Texas, MD Anderson Canc Ctr, Dept Gynecol Oncol, Unit 1362,POB 310439, Houston, TX 77230 USA. EM jmoroney@mdanderson.org NR 32 TC 6 Z9 7 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD JUN PY 2007 VL 105 IS 3 BP 672 EP 676 DI 10.1016/j.ygyno.2007.01.040 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 172PG UT WOS:000246815700019 PM 17363044 ER PT J AU Beck, HP Dzindolet, MT Pierce, LG AF Beck, Hall P. Dzindolet, Mary T. Pierce, Linda G. TI Automation usage decisions: Controlling intent and appraisal errors in a target detection task SO HUMAN FACTORS LA English DT Article ID ATTENTION ALLOCATION; EVENT-DRIVEN; TRUST; SYSTEMS; MISUSE; DISUSE; RELIABILITY; STRATEGIES; MANAGEMENT; FEEDBACK AB Background: It was proposed that misuse and disuse often occur because operators (a) cannot determine if automation or a nonautomated alternative maximizes the likelihood of task success (appraisal errors) or (b) know the utilities of the options but disregard this information when deciding to use automation (intent errors). Objective: This investigation assessed the effectiveness of performance feedback, a procedure developed to attenuate appraisal errors, and scenario training, an intervention designed to decrease intent errors. Methods: Operators given feedback were told how many errors they and an automated device made on a target detection task. Scenario training took operators through the thought processes of optimal decision makers after the utilities of the automated and nonautomated alternatives had been determined. Following 200 training trials, participants chose between relying on their observations or an automated device. Results: There was little misuse, but disuse rates were high (84%) among operators receiving neither feedback nor scenario training. Operators paired with a more accurate machine and given feedback made approximately twice as many errors as the automated device. Nevertheless, intent errors were commonplace; 55% of the operators who received feedback without scenario training did not rely on automation. Feedback effectiveness was enhanced when used in conjunction with scenario training; the disuse rate decreased to 29%. Conclusion: A combination of feedback and scenario training was more effective in mitigating disuse than either intervention used in isolation. Application: An important application of these findings is that operator training programs should incorporate techniques to control intent and appraisal errors. C1 Appalachian State Univ, Dept Psychol, Boone, NC 28608 USA. Cameron Univ, Lawton, OK 73505 USA. USA, Res Lab, Aberdeen, MD USA. RP Beck, HP (reprint author), Appalachian State Univ, Dept Psychol, Boone, NC 28608 USA. EM beckhp@appstate.edu NR 35 TC 17 Z9 17 U1 1 U2 2 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 USA SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD JUN PY 2007 VL 49 IS 3 BP 429 EP 437 DI 10.1518/001872007X200076 PG 9 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA 170XQ UT WOS:000246699900006 PM 17552307 ER PT J AU Whitman, GM Schwering, FK Wu, MYC AF Whitman, Gerald M. Schwering, Felix K. Wu, Michael Y. -C. TI Collimated beam wave pulse propagation and scattering in vegetation using scalar transport theory SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article DE beam waves; propagation in vegetation; scattering in random media; transport theory AB This investigation develops a theoretical model for microwave and mm-wave propagation and scattering in vegetation that is based on radiative transfer theory (transport theory). The time-dependent, three dimensional, scalar radiative transport equation is solved (to a high degree analytically and then numerically) for strong forward scattering of a pulsed collimated beam wave in a strong forward scattering environment such as a forest at mm-wave frequencies. The problem analyzed is that of a periodic sequence of Gaussian pulses incident from free space onto a forest region. The forest is modeled as a half-space of randomly distributed particles that scatter and absorb electromagnetic energy. The incident pulse train is taken to be a collimated (cylindrical) beam wave. The theory allows for a comprehensive characterization of the influence of vegetation on the propagation of pulsed beam waves, which includes a description of the attenuation of these beams, their angular spread, their distortion due to pulse broadening, and the determination of out-of-the-beam scattering which was not previously available. The model should be useful for frequencies above 3 GHz. C1 New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. USA, CECOM, Ft Monmouth, NJ 07702 USA. RP Whitman, GM (reprint author), New Jersey Inst Technol, Dept Elect & Comp Engn, Newark, NJ 07102 USA. EM whitman@njit.edu NR 17 TC 4 Z9 4 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD JUN PY 2007 VL 55 IS 6 BP 1599 EP 1612 DI 10.1109/TAP.2007.897302 PN 1 PG 14 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 178MA UT WOS:000247223600013 ER PT J AU Owens, FJ Gupta, A Rao, KV Iqbal, Z Guillen, JMO Ahuja, R Guo, JH AF Owens, Frank J. Gupta, Amita Rao, K. V. Iqbal, Zafar Guillen, J. M. Osorio Ahuja, R. Guo, J.-H. TI Unusual room temperature ferromagnetism in bulk sintered GaP doped with copper SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 10th Joint Magnetism and Magnetic Materials Conference/International Magnetics Conference CY JAN 07-11, 2007 CL Balitmore, MD SP Amer Inst Phys, IEEE, Magnet Soc DE GaP : Cu; magnetic resonance; magnetic semiconductors; materials science and technology; spintronics ID III-V SEMICONDUCTORS; MICROWAVE-ABSORPTION AB Robust room temperature ferromagnetism is obtained in single phase Gallium Phosphide doped with Cu2+ prepared by simple solid state reaction route. The saturation magnetization at 300 K is 1.5 x 10(-2) emu/g and the coercivity was found to be 125 Oe. A strong ferromagnetic resonance signal confirms the long range magnetic order which persists to temperatures as high as 739 K. X-ray absorption spectroscopy (XAS) indicate that Cu is in a +2 state. Ab initio calculations also show that the ferromagnetic ordering is energetically favorable in Cu doped GaP. When the spin-orbit coupling is included we get an enhanced total magnetic moment of 0.31 mu(B) with a local moment on Cu 0.082 and on P 0.204 mu(B). per atom. C1 USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. CUNY Hunter Coll, Dept Phys, New York, NY 10024 USA. Royal Inst Technol, Dept Mat Sci & Engn, SE-10044 Stockholm, Sweden. New Jersey Inst Technol, Dept Chem, Newark, NJ 07102 USA. Univ Uppsala, Dept Phys, Condensed Matter Theory Grp, S-75121 Uppsala, Sweden. Natl Renewable Energy Lab, Solid State Theory Grp, Golden, CO 80401 USA. Univ Calif Berkeley, Lawrence Berkeley Lab, Adv Light Source, Berkeley, CA 94720 USA. RP Owens, FJ (reprint author), USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA. EM rao@kth.se RI Osorio-Guillen, Jorge/B-7587-2008; Rao, K.V./F-4577-2011 OI Osorio-Guillen, Jorge/0000-0002-7384-8999; NR 12 TC 4 Z9 4 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JUN PY 2007 VL 43 IS 6 BP 3043 EP 3045 DI 10.1109/TMAG.2007.893998 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 171AB UT WOS:000246706200317 ER PT J AU Olague, HM Etzkorn, LH Gholston, S Quattlebaum, S AF Olague, Hector M. Etzkorn, Letha H. Gholston, Sampson Quattlebaum, Stephen TI Empirical validation of three software metrics suites to predict fault-proneness of object-oriented classes developed using highly iterative or agile software development processes SO IEEE TRANSACTIONS ON SOFTWARE ENGINEERING LA English DT Article DE object-oriented software metrics; object-oriented metrics; software quality metrics; software maintenance programming; software reuse ID SYSTEMS; DESIGN AB Empirical validation of software metrics suites to predict fault proneness in object-oriented (OO) components is essential to ensure their practical use in industrial settings. In this paper, we empirically validate three OO metrics suites for their ability to predict software quality in terms of fault-proneness: the Chidamber and Kemerer (CK) metrics, Abreu's Metrics for Object-Oriented Design ( MOOD), and Bansiya and Davis' Quality Metrics for Object-Oriented Design (QMOOD). Some CK class metrics have previously been shown to be good predictors of initial OO software quality. However, the other two suites have not been heavily validated except by their original proposers. Here, we explore the ability of these three metrics suites to predict fault-prone classes using defect data for six versions of Rhino, an open-source implementation of JavaScript written in Java. We conclude that the CK and QMOOD suites contain similar components and produce statistical models that are effective in detecting error-prone classes. We also conclude that the class components in the MOOD metrics suite are not good class fault-proneness predictors. Analyzing multivariate binary logistic regression models across six Rhino versions indicates these models may be useful in assessing quality in OO classes produced using modern highly iterative or agile software development processes. C1 USA, Space & Missile Def Command, SMDC RDTI S, Huntsville, AL 35807 USA. Univ Alabama, Dept Comp Sci, Huntsville, AL 35899 USA. Univ Alabama, Ind & Syst Engn & Engn Management Dept, Huntsville, AL 35899 USA. Dragonfly Athlet, Hartselle, AL 35640 USA. RP Olague, HM (reprint author), USA, Space & Missile Def Command, SMDC RDTI S, POB 1500, Huntsville, AL 35807 USA. EM holague@cs.uah.edu; letzkorn@cs.uah.edu; gholston@ise.uah; stephen@covidimus.net NR 23 TC 70 Z9 71 U1 2 U2 19 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 0098-5589 EI 1939-3520 J9 IEEE T SOFTWARE ENG JI IEEE Trans. Softw. Eng. PD JUN PY 2007 VL 33 IS 6 BP 402 EP 419 DI 10.1109/TSE.2007.1015 PG 18 WC Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 160PJ UT WOS:000245954500003 ER PT J AU Salazar, JC Rathi, A Michael, NL Radolf, JD Jagodzinski, LL AF Salazar, Juan C. Rathi, Asha Michael, Nelson L. Radolf, Justin D. Jagodzinski, Linda L. TI Assessment of the kinetics of Treponema pallidum dissemination into blood and tissues in experimental syphilis by real-time quantitative PCR SO INFECTION AND IMMUNITY LA English DT Article ID LYMPHOCYTE RESPONSIVENESS; CONGENITAL-SYPHILIS; SUBSP PALLIDUM; RABBIT; INFECTION; LESIONS; IDENTIFICATION; PROTECTION; DIAGNOSIS; STRAIN AB Little is known about the size and kinetics of treponemal burdens in blood and tissues during acquired or experimental syphilitic infection. We used real-time quantitative PCR to measure Treponema pallidum DNA levels in rabbits infected intratesticularly with the prototype Nichols strain. At the outset, we performed a series of in vitro blood spiking experiments to determine the effect of blood processing procedures on the distribution of treponemes in various blood components. T. pallidum DNA levels in plasma and whole blood were approximately 10-fold higher than those in serum and more than 200-fold greater than those in peripheral blood mononuclear cells (PBMCs). Ten rabbits were inoculated intratesticularly with doses of treponernes ranging from 4 x 10(7) to 2 x 10(8) organisms. In five rabbits, T. pallidum DNA levels were measured sequentially in serum, plasma, whole blood, and PBMCs until sacrifice at peak orchitis, at which time brain, kidney, liver, spleen, and testicles were harvested; blood and organs were also harvested at orchitis from the other five rabbits. T. pallidum DNA was detected in plasma within 24 h postinfection. Treponeme levels in whole blood and blood components increased significantly with the development of peak orchitis. Overall, levels in serum and PBMCs were lower than those in plasma and whole blood; this disparity was particularly marked at early time points. Significantly greater numbers of spirochetes were found in the spleen than in liver, kidney, or brain tissue at the time of sacrifice. Our findings highlight the remarkable capacity of T. pallidum to disseminate from the site of infection to blood and tissues, and they identify the spleen as a prime target for treponemal invasion. C1 Walter Reed Army Inst Res, Rockville, MD 20850 USA. Henry M Jackson Fdn, Rockville, MD 20850 USA. Connecticut Childrens Med Ctr, Div Pediat Infect Dis, Dept Pediat, Hartford, CT 06106 USA. Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA. Univ Connecticut, Ctr Hlth, Dept Genet & Dev Biol, Farmington, CT 06030 USA. RP Jagodzinski, LL (reprint author), Walter Reed Army Inst Res, 1600 E Gude Dr, Rockville, MD 20850 USA. EM ljagodzinski@hivresearch.org FU NIAID NIH HHS [AI 38894, AI 26756, K23 AI062439, R37 AI026756, 1K23 AI 62439-01A1, K23 AI062439-02, R01 AI026756, R01 AI038894] NR 38 TC 17 Z9 18 U1 0 U2 18 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 2007 VL 75 IS 6 BP 2954 EP 2958 DI 10.1128/IAI.00090-07 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 172SN UT WOS:000246824500034 PM 17438037 ER PT J AU Fernandes, PJ Guo, Q Waag, DM Donnenberg, MS AF Fernandes, Paula J. Guo, Qin Waag, David M. Donnenberg, Michael S. TI The type IV pilin of Burkholderia mallei is highly immunogenic but fails to protect against lethal aerosol challenge in a murine model SO INFECTION AND IMMUNITY LA English DT Article ID ENTEROPATHOGENIC ESCHERICHIA-COLI; BUNDLE-FORMING PILUS; INFECTIOUS BOVINE KERATOCONJUNCTIVITIS; BALB/C MICE; MORAXELLA-BOVIS; GLANDERS; VACCINE; LOCALIZATION; EFFICACY; STRAINS AB Burkholderia mallei is the cause of glanders and a proven biological weapon. We identified and purified the type IV pilin protein of this organism to study its potential as a subunit vaccine. We found that purified pillin was highly immunogenic. Furthermore, mice infected via sublethal aerosol challenge developed significant increases in titers of antibody against the pillin, suggesting that it is expressed in vivo. Nevertheless, we found no evidence that high-titer antipilin antisera provided passive protection against a sublethal or lethal aerosol challenge and no evidence of protection afforded by active immunization with purified pilin. These results contrast with the utility of type IV pilin subunit vaccines against other infectious diseases and highlight the need for further efforts to identify protective responses against this pathogen. C1 Univ Maryland, Sch Med, Div Infect Dis, Baltimore, MD 21201 USA. USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Donnenberg, MS (reprint author), Univ Maryland, Sch Med, Div Infect Dis, 20 Penn St,HSF2 S403D, Baltimore, MD 21201 USA. EM mdonnenb@umaryland.edu FU NIAID NIH HHS [R03 AI054690, R03 AI 54690, R01 AI037606, R01 AI 37606] NR 27 TC 17 Z9 17 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 2007 VL 75 IS 6 BP 3027 EP 3032 DI 10.1128/IAI.00150-07 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 172SN UT WOS:000246824500044 PM 17403869 ER PT J AU Griffith, ME Lazarus, DR Mann, PB Boger, JA Hospenthal, DR Murray, CK AF Griffith, Matthew E. Lazarus, Donald R. Mann, Paul B. Boger, John A. Hospenthal, Duane R. Murray, Clinton K. TI Acinetobacter skin carriage among US army soldiers deployed in Iraq SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY LA English DT Article ID BAUMANNII; BACTERIA AB Skin carriage of Acinetobacter calcoaceticus-baumannii complex was not detected among a representative sample of 102 US Army soldiers stationed in Iraq. This observation refutes the hypothesis that preinjury skin carriage serves as the reservoir for the Acinetobacter infections seen in US military combat casualties. C1 Brooke Army Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA. Darnall Army Community Hosp, Dept Med, Ft Hood, TX USA. Walter Reed Army Med Ctr, Dept Med, Washington, DC 20307 USA. RP Griffith, ME (reprint author), Brooke Army Med Ctr, Infect Dis Clin MCHE MDI, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM matthew.griffith@amedd.army.mil RI Valle, Ruben/A-7512-2013 NR 10 TC 38 Z9 39 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0899-823X J9 INFECT CONT HOSP EP JI Infect. Control Hosp. Epidemiol. PD JUN PY 2007 VL 28 IS 6 BP 720 EP 722 DI 10.1086/518966 PG 3 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 205NQ UT WOS:000249121300014 PM 17520547 ER PT J AU Krausman, AS Nussbaum, MA AF Krausman, Andrea S. Nussbaum, Maury A. TI Effects of wearing chemical protective clothing on text entry when using wearable input devices SO INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS LA English DT Article DE wearable computing; human computer interaction; equipment compatibility; extreme environments ID MEDICAL TASKS; PERFORMANCE; ENSEMBLE AB Wearable computers allow users the freedom to work in any environment including those that may require protective clothing. Past research has shown that protective clothing impedes performance on manual dexterity tasks. Little information exists; however, regarding how protective clothing affects task performance with wearable input devices. A study was conducted to determine the effects of glove thickness and mask use on task performance and user preference. Sixteen male participants used both a wearable mouse and touch pad to enter text. Task completion times were 9% slower when participants wore 25-mil versus 7-mil protective gloves, suggesting that thin protective gloves are more suitable than thicker gloves when using wearable input devices. Mask use did not affect task performance. Subjective ratings of difficulty, confidence, and preference provided strong support for the use of a touch pad device rather than a mouse. Potential applications of this research include design guidelines for development of wearable input devices that are compatible with chemical protective clothing. C1 Virginia Tech, Dept Ind & Syst Engn, Blacksburg, VA 24061 USA. USA, Res Lab, Aberdeen Proving Ground, MD USA. RP Nussbaum, MA (reprint author), Virginia Tech, Dept Ind & Syst Engn, 250 Durham Hall 0118, Blacksburg, VA 24061 USA. EM nussbaum@vt.edu RI Nussbaum, Maury/A-9655-2008 OI Nussbaum, Maury/0000-0002-1887-8431 NR 16 TC 11 Z9 11 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-8141 J9 INT J IND ERGONOM JI Int. J. Ind. Ergon. PD JUN PY 2007 VL 37 IS 6 BP 525 EP 530 DI 10.1016/j.ergon.2007.02.008 PG 6 WC Engineering, Industrial; Ergonomics SC Engineering GA 198FN UT WOS:000248612500006 ER PT J AU Freed, MC Rohan, KJ Yates, BT AF Freed, Michael C. Rohan, Kelly J. Yates, Brian T. TI Estimating health utilities and quality adjusted life years in seasonal affective disorder research SO JOURNAL OF AFFECTIVE DISORDERS LA English DT Article DE quality adjusted life year; cost-effectiveness; depression; seasonal affective disorder; health utility ID COST-EFFECTIVENESS ANALYSIS; PRIMARY-CARE; LIGHT THERAPY; DEPRESSION; PREFERENCES AB Background: Seasonal affective disorder (SAD) episodes will recur annually without effective intervention. Effectiveness of such interventions is traditionally measured with depression-specific tools (e.g., Beck Depression Inventory 2nd Edition; BDI-II). In a climate of potentially scarce resources, generic outcomes, such as Quality Adjusted Life Years (QALYs), are recommended for cost-effectiveness research. For treatments to be deemed cost-effective, they must show effectiveness relative to each other and relative to interventions across other disorders. To date, QALYs have not been used to determine effectiveness of SAD treatments. Given the recurrent nature of SAD, QALYs, which weight quality of life with time, are an ideal SAD treatment outcome. Method: A method to assess QALYs for SAD was developed using pilot clinical trial data. The method estimated health utilities, a measure of quality of life for a QALY, by anchoring pilot BDI-II data from the SAD clinical trial with previously derived health utilities for nonseasonal depression. Results: Relative to no treatment, median QALYs gained ranged from 0.11-0.18 over 1 year, depending on the intervention assessed. Discussion: Any treatment for SAD must compete with spontaneous spring remission, as illness severity attenuates in the spring. Limitations: Health utilities were estimated from the depression literature, and potential side effects from SAD treatments were not included in the estimates. The clinical trial time horizon was limited to 1-year. Conclusions: The proposed method offers researchers a tool to transform SAD efficacy data into a generic outcome for use in cost-effectiveness analysis of SAD treatments. (C) 2006 Elsevier B.V. All rights reserved. C1 American Univ, Dept Psychol, Washington, DC 20016 USA. Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA. RP Freed, MC (reprint author), Walter Reed Army Med Ctr, Deployment Hlth Clin Ctr, Washington, DC 20307 USA. EM mc_freed@onebox.com NR 26 TC 2 Z9 2 U1 1 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-0327 J9 J AFFECT DISORDERS JI J. Affect. Disord. PD JUN PY 2007 VL 100 IS 1-3 BP 83 EP 89 DI 10.1016/j.jad.2006.09.038 PG 7 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA 185IK UT WOS:000247704400011 PM 17084462 ER PT J AU Crane, CC AF Crane, Conrad C. TI Weapons of choice: The development of precision guided munitions SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Crane, Conrad C.] USA, War Coll, Carlisle, PA USA. RP Crane, CC (reprint author), USA, War Coll, Carlisle, PA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD JUN PY 2007 VL 94 IS 1 BP 329 EP 330 PG 2 WC History SC History GA 289VC UT WOS:000255081000129 ER PT J AU Canedy, S AF Canedy, Susan TI Political indoctrination in the US army from World War II to the Vietnam War SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review C1 [Canedy, Susan] USA, Acess Command, Ft Monroe, VA USA. RP Canedy, S (reprint author), USA, Acess Command, Ft Monroe, VA USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 USA SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD JUN PY 2007 VL 94 IS 1 BP 330 EP 331 PG 2 WC History SC History GA 289VC UT WOS:000255081000130 ER PT J AU Smith, ML Vorce, SP Holler, JM Shimomura, E Magluilo, J Jacobs, AJ Huestis, MA AF Smith, Michael L. Vorce, Shawn P. Holler, Justin M. Shimomura, Eric Magluilo, Joe Jacobs, Aaron J. Huestis, Marilyn A. TI Modern instrumental methods in forensic toxicology SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Review ID TANDEM MASS-SPECTROMETRY; PRESSURE CHEMICAL-IONIZATION; PERFORMANCE LIQUID-CHROMATOGRAPHY; 2-DIMENSIONAL GAS-CHROMATOGRAPHY; TIME-OF-FLIGHT; SOLID-PHASE EXTRACTION; LC-MS-MS; SULFATED-GAMMA-CYCLODEXTRIN; CONTROLLED ORAL CODEINE; GC-EI-MS C1 Armed Forces Inst Pathol, Off Armed Forces Med Examiner, Div Forens Toxicol, Rockville, MD 20850 USA. USA, Med Dept Board, Ft Sam Houston, TX 78234 USA. NIDA, Intramural Res Program, NIH, Baltimore, MD 21224 USA. RP Smith, ML (reprint author), Armed Forces Inst Pathol, Off Armed Forces Med Examiner, Div Forens Toxicol, 1413 Res Blvd,Bldg 102, Rockville, MD 20850 USA. EM smithml@afip.osd.mil FU Intramural NIH HHS [Z01 DA000414-10, Z01 DA000412-10] NR 189 TC 18 Z9 18 U1 2 U2 17 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 USA SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD JUN PY 2007 VL 31 IS 5 BP 237 EP 253 PG 17 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA 179MY UT WOS:000247295200001 PM 17579968 ER PT J AU Brown, E Hommerich, U Bluiett, AG Trivedi, SB Zavada, JM AF Brown, E. Hommerich, U. Bluiett, A. G. Trivedi, S. B. Zavada, J. M. TI Synthesis and spectroscopic properties of neodymium doped lead chloride SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID RARE-EARTH IONS; MULTIPHONON RELAXATION; OPTICAL-PROPERTIES; CRYSTAL-GROWTH; UP-CONVERSION; LASER; KPB2BR5; LACL3; INTENSITIES; EMISSION AB The crystal growth and infrared spectroscopic properties of Nd doped lead chloride (Nd:PbCl2) are reported. Lead halide based materials have recently emerged as laser hosts with low maximum phonon energies. In this work, Nd:PbCl2 crystals were grown by a self-seeded Bridgman technique. Following optical pumping at 750 and 808 nm, Nd:PbCl2 exhibited several infrared (IR) emission lines between 800 and 1600 nm as well as a broad mid-IR band centered at similar to 5.19 mu m. It was found that for Nd3+ concentrations larger than similar to 1x10(19) cm(-3), the mid-IR emission is predominantly due to the transition I-4(11/2)-> I-4(9/2). From a Judd-Ofelt analysis, the radiative quantum efficiency of the 5.19 mu m emission was determined to be similar to 27%. The multiphonon decay rates of several closely spaced Nd3+ transitions were modeled using the well known energy-gap law and the host dependent parameters B and beta were determined to be 9.5x10(9) s(-1) and 1.26x10(-2) cm, respectively. The obtained energy-gap law parameters were subsequently used to describe the temperature dependence of the 5.19 mu m mid-IR emission lifetime for a range from 77 to 450 K. (c) 2007 American Institute of Physics. C1 Hampton Univ, Dept Phys, Hampton, VA 23668 USA. Elizabeth City Stat Univ, Dept Chem & Phys, Elizabeth, NC 27909 USA. Brimrose Corp Amer, Baltimore, MD 21152 USA. USA, Res Off, Durham, NC 27709 USA. RP Brown, E (reprint author), Hampton Univ, Dept Phys, Hampton, VA 23668 USA. EM eiei.nyein@hamptonu.edu NR 26 TC 5 Z9 5 U1 0 U2 10 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 1 PY 2007 VL 101 IS 11 AR 113103 DI 10.1063/1.2738418 PG 7 WC Physics, Applied SC Physics GA 179QW UT WOS:000247306000003 ER PT J AU Xiao, D Kim, KW Zavada, JM AF Xiao, D. Kim, K. W. Zavada, J. M. TI Imaging properties of a metallic photonic crystal SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID NEGATIVE-INDEX; SLAB; REFRACTION AB Imaging effects in metallic photonic crystals (PCs) are examined theoretically based on the finite difference time-domain method. The analysis shows that, in metallic PC-based systems, far-field images do form at the opposite side of the PC "lens" and more importantly, follow the rule of geometric optics with respect to the changes in the source position as a direct proof of negative refraction. However, the comparison of ideal left-handed media with a metallic PC suggests that the focusing effect in the PC based system is different from that of the ideal left-handed media in many aspects, due to the inhomogeneous nature of the PC. Particularly, strong dependence on the individual geometry as well as the frequency in the PC-based system renders the effective index sensitive to the variations and potentially limits its application as a superlens. (c) 2007 American Institute of Physics. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Kim, KW (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. EM kwk@ncsu.edu NR 25 TC 3 Z9 3 U1 0 U2 2 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0021-8979 EI 1089-7550 J9 J APPL PHYS JI J. Appl. Phys. PD JUN 1 PY 2007 VL 101 IS 11 AR 113105 DI 10.1063/1.2737771 PG 5 WC Physics, Applied SC Physics GA 179QW UT WOS:000247306000005 ER PT J AU Sundermeyer, MA Terray, EA Ledwell, JR Cunningham, AG LaRocque, PE Banic, J Lillycrop, WJ AF Sundermeyer, M. A. Terray, E. A. Ledwell, J. R. Cunningham, A. G. LaRocque, P. E. Banic, J. Lillycrop, W. J. TI Three-dimensional mapping of fluorescent dye using a scanning, depth-resolving airborne lidar SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article ID FISH SCHOOLS; FLUCTUATIONS; BACKSCATTER; DIFFUSION; INVERSION; WATERS AB Results are presented from a pilot study using a fluorescent dye tracer imaged by airborne lidar in the ocean surface layer on spatial scales of meters to kilometers and temporal scales of minutes to hours. The lidar used here employs a scanning, frequency-doubled Nd:YAG laser to emit an infrared (1064 nm) and green (532 nm) pulse 6 ns in duration at a rate of I kHz. The received signal is split to infrared, green, and fluorescent (nominally 580-600 nm) channels, the latter two of which are used to compute absolute dye concentration as a function of depth and horizontal position. Comparison of dye concentrations inferred from the lidar with in situ fluorometry measurements made by ship shows good agreement both qualitatively and quantitatively for absolute dye concentrations ranging from 1 to > 10 ppb. Uncertainties associated with horizontal variations in the natural seawater attenuation are approximately 1 ppb. The results demonstrate the ability of airborne lidar to capture high-resolution three-dimensional "snapshots" of the distribution of the tracer as it evolves over very short time and space scales. Such measurements offer a powerful observational tool for studies of transport and mixing on these scales. C1 Univ Massachusetts Dartmouth, Sch Marine Sci & Technol, New Bedford, MA 02744 USA. Woods Hole Oceanog Inst, Dept Appl Ocean Phys & Engn, Woods Hole, MA 02543 USA. Optech Inc, Toronto, ON, Canada. USA, Corps Engineers, Joint Airborne LIDAR Bathymetry Tech Ctr Expertis, Mobile, AL USA. RP Sundermeyer, MA (reprint author), Univ Massachusetts Dartmouth, Sch Marine Sci & Technol, 706 Rodney French Blvd, New Bedford, MA 02744 USA. EM msundermeyer@umassd.edu NR 22 TC 10 Z9 10 U1 1 U2 5 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 USA SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD JUN PY 2007 VL 24 IS 6 BP 1050 EP 1065 DI 10.1175/JTECH2027.1 PG 16 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA 179CG UT WOS:000247266300009 ER PT J AU Tsang, RSW Henderson, AM Cameron, ML Tyler, SD Tyson, S Law, DKS Stoltz, J Zollinger, WD AF Tsang, Raymond S. W. Henderson, Averil M. Cameron, Marissa L. Tyler, Shaun D. Tyson, Shari Law, Dennis K. S. Stoltz, Jan Zollinger, Wendell D. TI Genetic and antigenic analysis of invasive serogroup Y Neisseria meningitidis isolates collected from 1999 to 2003 in Canada SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID C MENINGOCOCCAL DISEASE; SIAD PCR-ELISA; CONJUGATE VACCINE; MOLECULAR EPIDEMIOLOGY; MONOCLONAL-ANTIBODIES; CHANGING EPIDEMIOLOGY; IMMUNOGENICITY; IDENTIFICATION; SURVEILLANCE; EMERGENCE AB One hundred forty serogroup Y Neisseria meningitidis isolates recovered from patients with invasive meningococcal disease (IMD) in Canada from 1999 to 2003 were analyzed by genetic and serological methods. Seventy-four isolates (52.9%) belonged to serotype 2c, and most have serosubtype antigen P1.5,2 (37 isolates, 26%) or P1.5 (31 isolates, 22%). Forty-eight isolates (34.3%) belonged to serotype 14 and have serosubtype antigen P1.5,2 (13 isolates, 9%) or P1.5 (7 isolates, 5%) or were nonserosubtypeable (27 isolates, 19%). Thirteen isolates (9.3%) were nonserotypeable. Multilocus sequence typing identified two unrelated clonal populations of serogroup Y meningococci causing invasive disease in Canada: ST-23 and ST-167 clonal complexes. Almost all ST-167-related isolates were typed as 2c:P1.5, while strains of the ST-23 clonal complex were either serotype 14 or 2c but with the serosubtype antigen P1.5,2. In contrast to previous reports that patients with serogroup Y disease are usually older, 26% of the Canadian serogroup Y cases were found in the 10-to-19-year-old age group and another 11% were in the 20-to-39-year-old age group. C1 Publ Hlth Agcy Canada, Natl Microbiol Lab, Lab Vaccine Preventable Bacterial Dis, Winnipeg, MB R3E 3R2, Canada. Publ Hlth Agcy Canada, Natl Microbiol Lab, DNA Core Facil, Winnipeg, MB R3E 3R2, Canada. Walter Reed Army Inst Res, Dept Bacterial Dis, Silver Spring, MD USA. RP Tsang, RSW (reprint author), Publ Hlth Agcy Canada, Natl Microbiol Lab, Lab Vaccine Preventable Bacterial Dis, 1015 Arlington St, Winnipeg, MB R3E 3R2, Canada. EM Raymond_Tsang@phac-aspc.gc.ca RI Zollinger, Wendell/B-2887-2011 NR 40 TC 18 Z9 18 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 2007 VL 45 IS 6 BP 1753 EP 1758 DI 10.1128/JCM.02134-06 PG 6 WC Microbiology SC Microbiology GA 179JT UT WOS:000247286500013 PM 17442798 ER PT J AU Sarang, S Sastry, SK Gaines, J Yang, TCS Dunne, P AF Sarang, S. Sastry, S. K. Gaines, J. Yang, T. C. S. Dunne, P. TI Product formulation for ohmic heating: Blanching as a pretreatment method to improve uniformity in of solid-liquid food heating mixtures SO JOURNAL OF FOOD SCIENCE LA English DT Article DE blanching; electrical conductivity; ohmic heating; product formulation; salt infusion ID ELECTRICAL-CONDUCTIVITY; VEGETABLE TISSUE; SALT DIFFUSION AB The electrical conductivity of food components is critical to ohmic heating. Food components of different electrical conductivities heat at different rates. While equal electrical conductivities of all phases are desirable, real food products may behave differently. In the present study involving chicken chow mein consisting of a sauce and different solid components, celery, water chestnuts, mushrooms, bean sprouts, and chicken, it was observed that the sauce was more conductive than all solid components over the measured temperature range. To improve heating uniformity, a blanching method was developed to increase the ionic content of the solid components. By blanching different solid components in a highly conductive sauce at 100 degrees C for different lengths of time, it was possible to adjust their conductivity to that of the sauce. Chicken chow mein samples containing blanched particulates were compared wi th untreated samples with respect to ohmic heating uniformity at 60 Hz up to 140 degrees C. All components of the treated product containing blanched solids heated more uniformly than untreated product. In sensory tests, 3 different formulations of the blanched product showed good quality attributes and overall acceptability, demonstrating the practical feasibility of the blanching protocol. C1 Ohio State Univ, Dept Food Agr & Biol Engn, Columbus, OH 43210 USA. USA, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Sastry, SK (reprint author), Ohio State Univ, Dept Food Agr & Biol Engn, 590 Woody Hayes Dr,206 Agr Engn Bldg, Columbus, OH 43210 USA. EM sastry2@osu.edu NR 11 TC 13 Z9 13 U1 1 U2 7 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD JUN-JUL PY 2007 VL 72 IS 5 BP E227 EP E234 DI 10.1111/j.1750-3841.2007.00380.x PG 8 WC Food Science & Technology SC Food Science & Technology GA 186LM UT WOS:000247780200020 PM 17995720 ER PT J AU Lee, S Carmody, B Wolfe, L DeMaria, E Kellum, JM Sugerman, H Maher, JW AF Lee, Sukhyung Carmody, Brennan Wolfe, Luke DeMaria, Eric Kellum, John M. Sugerman, Harvey Maher, James W. TI Effect of location and speed of diagnosis on anastomotic leak outcomes in 3828 gastric bypass cases SO JOURNAL OF GASTROINTESTINAL SURGERY LA English DT Article; Proceedings Paper CT 47th Annual Meeting of the Society-for-Surgery-of the Alimentary-Tract CY MAY 20-24, 2006 CL Los Angeles, CA SP Soc Surg Alimentary Tract DE gastric bypass; morbid obesity; gastric bypass leak complications; gastric bypass mortality ID MORBID-OBESITY; COMPLICATIONS; SURGERY AB Introduction Leaks after Roux-en-Y gastric bypass are a major cause of mortality. This study attempts to define the relationship between the leak site, time from surgery to detection, and outcome. Methods Retrospective review of 3,828 gastric bypass procedures. Results Of the leaks (3.9% overall), 60/ 2,337 ( 2.6%) occurred after open gastric bypass, 57/ 1,080 (5.2%) after laparoscopic gastric bypass, and 33/ 411 (8.0%) after revisions. Overall leak-related mortality after Roux-en-Y gastric bypass was 0.6% (22/ 3,828). Mortality rate from gastrojejunostomy leaks ( 38 in the open gastric bypass, and 43 in the laparoscopic) was higher in the open group than the laparoscopic group (18.4 vs 2.3%, p= 0.015). Median time of detection for a gastrojejunostomy leak in the open group was longer than in the laparoscopic group ( 3 vs 1 days, Wilcoxon score p < 0.001). Jejunojejunostomy (JJ) leak was associated with a 40% mortality rate. Initial upper gastrointestinal series did not detect 9/10 jejunojejunostomy leaks. Median detection time was longer in the jejunojejunostomy leak group than the gastrojejunostomy leak group ( 4 vs 2 days, p= 0.037). Discussion Leak mortality and time of detection was higher after open gastric bypass than laparoscopic gastric bypass. GBP patients with normal upper gastrointestinal (UGI) studies may harbor leaks, especially at the JJ or excluded stomach. Normal UGI findings should not delay therapy if clinical signs suggest a leak. C1 Virginia Commonwealth Univ, Dept Surg, Richmond, VA 23284 USA. William Beaumont Army Med Ctr, Dept Surg, El Paso, TX 79920 USA. Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Maher, JW (reprint author), Virginia Commonwealth Univ, Dept Surg, Med Coll Virginia Campus, Richmond, VA 23284 USA. EM jwmaher@vcu.edu NR 12 TC 51 Z9 52 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1091-255X J9 J GASTROINTEST SURG JI J. Gastrointest. Surg. PD JUN PY 2007 VL 11 IS 6 BP 708 EP 713 DI 10.1007/s11605-007-0085-3 PG 6 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA 178TE UT WOS:000247242200003 PM 17562118 ER PT J AU Barrier, BF Joiner, LLR Jimenez, JB Leland, MM AF Barrier, Breton F. Joiner, Laura Lee Rihl Jimenez, Joe B. Leland, M. Michelle TI External cephalic version of the term breech baboon (Papio sp.) fetus SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article DE baboon; breech 'cesarean section' pregnancy; malpresentation ID CESAREAN-SECTION AB Background Breech presentation in baboons may be associated with head entrapment and stillbirth during vaginal delivery. For this reason, pregnant dams at our institution typically undergo cesarean delivery for known breech presentation, leading to problems with maternal-infant bonding and increased nursery utilization. Methods This paper describes a simple, non-invasive technique called external cephalic version (ECV) that effectively converts the baboon breech fetus into a cephalic presentation. Results ECV was successful in each of seven attempted cases, with the consistent development of contractions and vaginal bleeding leading to the delivery of a healthy liveborn infant within 72 hours. Conclusions ECV may offer a safe and effective alternative to cesarean section for delivery of the breech baboon fetus. C1 Univ Missouri, Dept Obstet Gynecol & Womens Hlth, Div Reprod & Perinatal Res, Columbia, MO 65212 USA. Brooke Army Med Ctr, Dept Obstet & Gynecol, San Antonio, TX USA. SW Fdn Biomed Res, Dept Physiol & Med, San Antonio, TX 78284 USA. RP Barrier, BF (reprint author), Univ Missouri, Dept Obstet Gynecol & Womens Hlth, Div Reprod & Perinatal Res, Columbia, MO 65212 USA. EM barrierb@health.missouri.edu NR 7 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD JUN PY 2007 VL 36 IS 3 BP 148 EP 150 DI 10.1111/j.1600-0684.2006.00201.x PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA 165PJ UT WOS:000246317300005 PM 17517089 ER PT J AU Fritz, JM Cleland, JA Childs, JD AF Fritz, Julie M. Cleland, Joshua A. Childs, John D. TI Subgrouping patients with low back pain: Evolution of a classification approach to physical therapy SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Review DE clinical decision making; lumbar spine; manipulation; stabilization; traction ID RANDOMIZED CLINICAL-TRIAL; LUMBAR SPINAL STENOSIS; FEEDFORWARD POSTURAL RESPONSES; FEAR-AVOIDANCE BELIEFS; PRIMARY-CARE RESEARCH; PELVIC GIRDLE PAIN; OF-THE-LITERATURE; CENTRALIZATION PHENOMENON; SEGMENTAL INSTABILITY; PREDICTION RULE AB The development of valid classification methods to assist the physical therapy management of patients with low back pain has been recognized as a research priority. There is also growing evidence that the use of a classification approach to physical therapy results in better clinical outcomes than the use of alternative management approaches. In 1995 Delitto and colleagues proposed a classification system intended to inform and direct the physical therapy management of patients with low back pain. The system described 4 classifications of patients with low back pain (manipulation, stabilization, specific exercise, and traction). Each classification could be identified by a unique set of examination criteria, and was associated with an intervention strategy believed to result in the best outcomes for the patient. The system was based on expert opinion and research evidence available at the time. A substantial amount of research has emerged in the years since the introduction of this classification system, including the development of clinical prediction rules, providing new evidence for the examination criteria used to place a patient into a classification and for the optimal intervention strategies for each classification. New evidence should continually be incorporated into existing classification systems. The purpose of this clinical commentary is to review this classification system, its evolution and current status, and to discuss its implications for the classification of patients with low back pain. C1 Univ Utah, Div Phys Therapy, Salt Lake City, UT USA. Intermt Hlth Care, Salt Lake City, UT USA. Franklin Pierce Coll, Dept Phys Therapy, Concord, NH USA. Concord Hosp, Rehabil Serv, Concord, NH USA. Regis Univ, Manual Therapy Fellowship Program, Denver, CO USA. Baylor Univ, USA, Doctoral Program Phys Therapy, San Antonio, TX USA. RP Fritz, JM (reprint author), 520 Wakara Way, Salt Lake City, UT 84108 USA. EM julie.fritz1@comcast.net NR 132 TC 123 Z9 129 U1 6 U2 26 PU J O S P T, PI ALEXANDRIA PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD JUN PY 2007 VL 37 IS 6 BP 290 EP 302 DI 10.2519/jospt.2007.2498 PG 13 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA 177SA UT WOS:000247171600002 PM 17612355 ER PT J AU Duckworth, AL Peterson, C Matthews, MD Kelly, DR AF Duckworth, Angela L. Peterson, Christopher Matthews, Michael D. Kelly, Dennis R. TI Grit: Perseverance and passion for long-term goals SO JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY LA English DT Article DE achievement; success; personality; persistence; performance ID PERSONALITY-FACTORS; JOB-PERFORMANCE; BIG 5; INTELLIGENCE; METAANALYSIS; MOTIVATION; LIFE; ACHIEVEMENT; PREDICTORS; COMMITMENT AB The importance of intellectual talent to achievement in all professional domains is well established, but less is known about other individual differences that predict success. The authors tested the importance of 1 noncognitive trait: grit. Defined as perseverance and passion for long-term goals, grit accounted for an average of 4% of the variance in success outcomes, including educational attainment among 2 samples of adults (N = 1,545 and N = 690), grade point average among Ivy League undergraduates (N = 138), retention in 2 classes of United States Military Academy, West Point, cadets (N = 1,218 and N = 1,308), and ranking in the National Spelling Bee (N = 175). Grit did not relate positively to IQ but was highly correlated with Big Five Conscientiousness. Grit nonetheless demonstrated incremental predictive validity of success measures over and beyond IQ and conscientiousness. Collectively, these findings suggest that the achievement of difficult goals entails not only talent but also the sustained and focused application of talent over time. C1 Univ Penn, Dept Psychol, Philadelphia, PA 19104 USA. Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA. US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA. US Mil Acad, Inst Res & Anal Branch, West Point, NY 10996 USA. RP Duckworth, AL (reprint author), Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA. EM angela_duckworth@yahoo.com NR 63 TC 455 Z9 464 U1 36 U2 249 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0022-3514 J9 J PERS SOC PSYCHOL JI J. Pers. Soc. Psychol. PD JUN PY 2007 VL 92 IS 6 BP 1087 EP 1101 DI 10.1037/0022-3514.92.6.1087 PG 15 WC Psychology, Social SC Psychology GA 175CV UT WOS:000246991100009 PM 17547490 ER PT J AU Jensen, KB Palazzo, AJ Waldron, BL Bushman, BS AF Jensen, K. B. Palazzo, A. J. Waldron, B. L. Bushman, B. S. TI Registration of 'FirstStrike' Slender Wheatgrass SO JOURNAL OF PLANT REGISTRATIONS LA English DT Article C1 [Jensen, K. B.; Waldron, B. L.; Bushman, B. S.] Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. [Palazzo, A. J.] USA Corps Engineers, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA. RP Jensen, KB (reprint author), Utah State Univ, USDA ARS, Forage & Range Res Lab, Logan, UT 84322 USA. EM kevin@cc.usu.edu NR 1 TC 3 Z9 4 U1 0 U2 1 PU CROP SCIENCE SOC AMER PI MADISON PA 677 S SEGOE ROAD, MADISON, WI 53711 USA SN 1936-5209 J9 J PLANT REGIST JI J. Plant Regist. PD JUN PY 2007 VL 1 IS 1 BP 24 EP 25 DI 10.3198/jpr2006.11.0694crc PG 2 WC Agronomy; Plant Sciences SC Agriculture; Plant Sciences GA V05PR UT WOS:000207138400012 ER PT J AU Barnacle, SJ Robinson, RD Malinowski, MJ AF Barnacle, Scott J. Robinson, Randal D. Malinowski, Marshall J. TI Laparoscopic resection of a noncommunicating, rudimentary uterine horn using the harmonic scalpel - A report of 3 cases SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article DE uterus; laparoscopic surgery; rudimentary uterine horn; harmonic scalpel AB BACKGROUND: Nonconnnunicating, rudinientary uterine horns are Often removed to prevent potential pregnancy complications or to treat patients who develop pain from functional endometrimn within the horn. Historically, these have been removed via laparotomy. Recently, resections of noncommunicating uterine horns have been performed laparoscopically using many different devices. We report 3 patients who underwent laparoscopic resection using the harmonic scalpel. CASES: Three patients were diagnosed with this condition at our institution between 2000 and 2003. All underwent laparoscopic resection using the harmonic scalpel without complications. All patients were discharged from the hospital on the day of surgery. Two patients subsequently had term vaginal deliveries. CONCLUSION: Resection of a rudinientary uterine horn by laparoscopy using the harmonic scalpel is an option for patients diagnosed with noncommunicating, rudinientary uterine horns. This modality might offer some advantages for patients who must undergo resection. C1 Wilford Hall USAF Med Ctr, Brooke Army Med Ctr, San Antonio Uniformed Serv, Hlth Educ Consortium,Dept Obstet & Gynecol,Div Re, Lackland AFB, TX 78236 USA. RP Robinson, RD (reprint author), MDS, MMNO, 2200 Bergquist Dr,Suite 1, Lackland AFB, TX 78236 USA. EM robinson@lackland.af.mil NR 6 TC 3 Z9 3 U1 0 U2 0 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA PO DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 USA SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD JUN PY 2007 VL 52 IS 6 BP 570 EP 574 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 180HV UT WOS:000247354600028 PM 17694988 ER PT J AU Braun, TJ AF Braun, Thomas J. TI An alternative technique fop, applying accession numbers to museum artifacts SO JOURNAL OF THE AMERICAN INSTITUTE FOR CONSERVATION LA English DT Article AB For decades archaeologists and museum professionals have applied accession numbers to artifacts using a variety of methods. A common method has been the hand-numbering technique: a barrier layer is applied, over which the number is written in ink and after that has dried, another clear coating is applied. Recently, many archaeologists and museum professionals have sought alternative, more efficient methods for artifact numbering. This paper describes another technique that offers many advantages. The accession numbers are printed onto paper using a computer printer employing a small four, which is then cut out, and the paper label adhered to the artifact with an appropriate adhesive. This has many advantages over hand-numbering, though this paper recognizes that hand-numbering is still appropriate in many situations. In this alternative technique, the application of the numbers is a one-step process offering a large reduction in the amount of time required to label artifacts, and by extension, less handling of artifacts. Compared to hand-numbering, the legibility of the numbers is improved, even while the size of the numbers is reduced. Accession numbers can be printed from existing databases, which may reduce transcriptional errors. Additionally, the permanence of these labels is high, if certain procedures are followed when producing them. Lastly, this technique may require less manual dexterity than hand-numbering in order to properly and safely apply accession numbers. This technique may enable this task to be delegated to other staff members or volunteers. The purpose of this article is to document its use and provide specific details on its application to various types of objects, and to disseminate this information to the museum community as a whole. C1 USA Corps Engineers, St Louis, MO USA. RP Braun, TJ (reprint author), Minnesota Hist Soc, Conservat Dept, 345 Kellogg Blvd W, St Paul, MN 55102 USA. EM tom.braun@mnhs.org NR 30 TC 0 Z9 0 U1 0 U2 0 PU AMER INST CONSERVATION HISTORIC ARTISTIC WORKS PI WASHINGTON PA 1717 K ST, NW, STE 301, WASHINGTON, DC 20006 USA SN 0197-1360 J9 J AM INST CONSERV JI J. Am. Inst. Conserv. PD SUM PY 2007 VL 46 IS 2 BP 91 EP 104 PG 14 WC Humanities, Multidisciplinary SC Arts & Humanities - Other Topics GA 201JA UT WOS:000248826100001 ER PT J AU Shorr, AF Jackson, WL Moores, LK Warkentin, TE AF Shorr, Andrew F. Jackson, William L. Moores, Lisa K. Warkentin, Theodore E. TI Minimizing costs for treating deep vein thrombosis: the role for fondaparinux SO JOURNAL OF THROMBOSIS AND THROMBOLYSIS LA English DT Article DE anticoagulation; cost; deep vein thrombosis; enoxaparin; fondaparinux ID MOLECULAR-WEIGHT HEPARIN; INTRAVENOUS UNFRACTIONATED HEPARIN; MAJOR ORTHOPEDIC-SURGERY; INDUCED THROMBOCYTOPENIA; VENOUS THROMBOEMBOLISM; PULMONARY-EMBOLISM; INITIAL TREATMENT; ENOXAPARIN; THROMBOPROPHYLAXIS; PROPHYLAXIS AB Background Deep vein thrombosis (DVT) remains a major burden and fondaparinux represents a new option for DVT therapy. We sought to determine if fondaparinux offered financial advantages over low-molecular weight heparin since it is given as a fixed dose over a wide range of patient weights rather then dosed directly on weight and because fondaparinux is not associated with heparin-induced thrombocytopenia (HIT). Methods We conducted a cost-minimization analysis comparing fondaparinux to enoxaparin for acute anticoagulation in DVT. We modeled a cohort of 1,000 hypothetical subjects and drew estimates for model inputs from the published literature. We completed multiple sensitivity analyses to asses the significance of our assumptions and used Monte Carlo simulation to estimate the 95% confidence intervals (CIs) around our estimation of the cost differential for the two agents. Results In the base case, total disease management costs per patient with fondaparinux are $US 472 compared to $769 with enoxaparin. The 95% CI around this difference ranges from $US 48 to $US 401. The model was mildly sensitive to the pharmacy acquisition costs of fondaparinux and enoxaparin which was the major driver of overall costs. Neither the rates of nor costs associated with DVT recurrence, major bleeding, nor HIT substantially affected our observations. Breakeven analysis indicated our findings to be robust over a wide range of likely clinical scenarios. Conclusions From the perspective of a healthcare system, fondaparinux use offers an attractive economic alternative to other agents for initial DVT therapy. Expanded reliance on fondaparinux could potentially result in savings. C1 Washington Hosp Ctr, Washington, DC 20010 USA. Walter Reed Army Med Ctr, Crit Care Med Serv, Washington, DC 20307 USA. Walter Reed Army Med Ctr, Pulm & Crit Care Med Serv, Washington, DC 20307 USA. McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada. RP Shorr, AF (reprint author), Washington Hosp Ctr, 110 Irving St NW, Washington, DC 20010 USA. EM afshorr@dnamail.com NR 26 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0929-5305 J9 J THROMB THROMBOLYS JI J. Thromb. Thrombolysis PD JUN PY 2007 VL 23 IS 3 BP 229 EP 236 DI 10.1007/s11239-006-9042-3 PG 8 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA 154HH UT WOS:000245497000010 PM 17131172 ER PT J AU Kheirabadi, BS Crissey, JM Deguzman, R Holcomb, JB AF Kheirabadi, Bijan S. Crissey, Jacqueline M. Deguzman, Rodolfo Holcomb, John B. TI In vivo bleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy than prothrombin time SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 65th Annual Meeting of the American-Association-for-the-Surgery-of-Trauma CY SEP 28-30, 2006 CL New Orleans, LA SP Amer Assoc Surg Trauma DE coagulopathy; warfarin; hemodilution; hypothermia; hemorrhage model ID UNCONTROLLED HEMORRHAGIC-SHOCK; RECOMBINANT FACTOR VIIA; V LIVER INJURIES; ABNORMAL COAGULATION; TRAUMA; MODEL; RABBITS; PIGS; RESUSCITATION; HARMFUL AB Background: The coagulopathy of trauma is generally confirmed by prothrombin time (PT) >= 16 seconds or an international normalized ratio >= 1.5. However, the utility of these values as a screening test is unknown. We examined different coagulation tests to determine the best predictor of coagulopathic bleeding and mortality in a small animal hemorrhage model. Methods: Coagulopathy was induced in male New Zealand White rabbits by warfarin (W; 2 mg/kg for 2 days; n = 7), or hemodilution and hypothermia (HH; 50% blood exchange with Hextend, 34.5 +/- 0.3 degrees C; n = 7). Normal (N) rabbits without pretreatment served as the control (n = 7). Blood samples collected after coagulopathy induction and analyzed by prothrombin time (PT), activated partial thromboplastin time (aPTT), and thromboelastography (TEG) tests. Liver bleeding time (BT) was also measured before injury. An uncontrolled hemorrhage was created by a longitudinal splenic incision and the abdomen was closed. Rabbits were resuscitated with Hextend solution (25 mL/kg) to return blood pressure to baseline and monitored for 2 hours or until death at which time blood loss was measured. Results: Warfarin-induced coagulopathy increased BT, PT, and aPTT. TEG showed increased reaction (R) and clot formation (K) times and marked decrease in clotting rate (alpha angle and Vmax). Hemodilution hypothermia coagulopathy increased only BT and aPTT, and decreased the clotting rate (alpha angle and Vmax) and strength of the clot. After injury, blood losses were higher in coagulopathic rabbits (W = 54.6 +/- 4.2 and HH = 51.1 +/- 8.9 mL/kg) than in normal rabbits (30.6 +/- 12.4 mL/kg) and resulted in 86%, 100%, and 0% death, respectively. BT and Vmax consistently predicted coagulopathic bleeding and death in all animals. Conclusion: Although satisfactory in warfarin-induced coagulopathy, PT was not a valid screening test for dilutional and hypothermic coagulopathy. BT and TEG measurements of blood clotting rate are better indicators of coagulopathic bleeding and mortality in this lethal hemorrhage model. C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Kheirabadi, BS (reprint author), USA, Inst Surg Res, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM bijan.kheirabadi@cen.amedd.army.mil NR 40 TC 55 Z9 59 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 BP 1352 EP 1359 DI 10.1097/TA.0b013e318047b805 PG 8 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 179YM UT WOS:000247326600008 PM 17563647 ER PT J AU Baskin, T AF Baskin, Toney TI Cervical spine clearance in the obtunded patient: It takes more than a simple CT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID TRAUMA C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Baskin, T (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM toney.baskin@cen.amedd.army.mil NR 6 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S33 EP S33 DI 10.1097/TA.0b013e31806540b2 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600025 PM 17556958 ER PT J AU Beekley, AC AF Beekley, Alec C. TI Mass casualties in combat: Lessons learned SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID TRAUMA C1 USA, Med Corps, Madigan Army Med Ctr, Tacoma, WA USA. RP Beekley, AC (reprint author), USA, Med Corps, Madigan Army Med Ctr, Tacoma, WA USA. EM alec.beekley@amedd.army.mil NR 8 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S39 EP S40 DI 10.1097/TA.0b013e31806541e9 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600030 PM 17556963 ER PT J AU Cancio, LC Wolf, SE AF Cancio, Leopoldo C. Wolf, Steven E. TI Session summary burn SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. RP Cancio, LC (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM lee.cancio@amedd.army.mil; steven.wolf@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S66 EP S66 DI 10.1097/TA.0b013e318065ae43 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600048 ER PT J AU Eastridge, BJ AF Eastridge, Brian J. TI Things that go boom: Injuries from explosives SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S38 EP S38 DI 10.1097/TA.0b013e318065414f PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600029 PM 17556962 ER PT J AU Eastridge, BJ AF Eastridge, Brian J. TI Butt binder SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID CLASSIFICATION; HEMORRHAGE; MANAGEMENT C1 USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S32 EP S32 DI 10.1097/TA.0b013e3180654095 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600024 PM 17556957 ER PT J AU Eastridge, BJ AF Eastridge, Brian J. TI Session summary military trauma SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. RP Eastridge, BJ (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM brian.eastridge@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S34 EP S34 DI 10.1097/TA.0b013e31806540d5 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600026 ER PT J AU Fergason, J AF Fergason, John TI Clinical application of advanced prosthetic technology: An update SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Amputee Care Ctr, Ft Sam Houston, TX 78234 USA. RP Fergason, J (reprint author), Brooke Army Med Ctr, Amputee Care Ctr, Ft Sam Houston, TX 78234 USA. EM john.fergason@amedd.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S6 EP S6 DI 10.1097/TA.0b013e31806539f1 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600002 PM 17556978 ER PT J AU Gerhardt, R AF Gerhardt, Robert TI Impact of emergency medicine pre-hospital and en route care: Data say? SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Gerhardt, R (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM robett.gerhardt@amedd.arfny.mil NR 3 TC 4 Z9 4 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S11 EP S12 DI 10.1097/TA.0b013e31806533b3f PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600007 PM 17556936 ER PT J AU Holcomb, JB AF Holcomb, John B. TI Damage control resuscitation SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID FRESH-FROZEN PLASMA; FLUID RESUSCITATION; HEMORRHAGIC-SHOCK; MASSIVE TRANSFUSION; BLOOD-TRANSFUSION; WHOLE-BLOOD; TRAUMA; COAGULOPATHY; STRATEGIES; MORTALITY C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Holcomb, JB (reprint author), Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. EM john.holcomb@amedd.army.mil NR 42 TC 87 Z9 92 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S36 EP S37 DI 10.1097/TA.0b013e3180654134 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600028 PM 17556961 ER PT J AU Johnson, AJ AF Johnson, Anthony J. TI Eye trauma Management - 0IF clinical considerations SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Johnson, AJ (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM anthonyjohnson2@amedd.arfny.mil NR 0 TC 5 Z9 5 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S20 EP S20 DI 10.1097/TA.0b013e3180653eb7 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600014 PM 17556946 ER PT J AU McManus, JG Eastridge, BJ Wade, CE Holcomb, JB AF McManus, John G. Eastridge, Brian J. Wade, Charles E. Holcomb, John B. TI Hemorrhage control research on today's battlefield: lessons applied SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP McManus, JG (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 0 TC 20 Z9 21 U1 2 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S14 EP S14 DI 10.1097/TA.0b013e3180653b6d PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600009 PM 17556941 ER PT J AU McManus, JG Eastridge, BJ DeWitte, M Greydanus, DJ Rice, J Holcomb, JB AF McManus, John G. Eastridge, Brian J. DeWitte, Monica Greydanus, Dominique J. Rice, James Holcomb, John B. TI Combat trauma training for current casualty care SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP McManus, JG (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM john.mcmanus@amedd.army.mil NR 0 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S13 EP S13 DI 10.1097/TA.0b013e3180653b7e PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600008 PM 17556940 ER PT J AU Menetrez, J King, J AF Menetrez, Jennifer King, John TI Session summary physical medicine and rehabilitation SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Editorial Material C1 Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, Dept Rehabil Med, San Antonio, TX USA. RP Menetrez, J (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ft Sam Houston, TX 78234 USA. EM Jennifer.Menetrez@amedd.army.mil; kingj@uthscsa.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S3 EP S5 DI 10.1097/TA.0b013e3180653916 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600001 ER PT J AU Molter, NC AF Molter, Nancy C. TI Exemption of informed consent (Final rule): Procedures for critical trauma studies SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID RESUSCITATION C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Molter, NC (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM nancy.molter@amedd.army.mil NR 13 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S78 EP S79 DI 10.1097/TA.0b013e318065b1a9 PG 2 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600059 PM 17556994 ER PT J AU Morey, AF AF Morey, Allen F. TI Simplified reconstruction of traumatic posterior urethral defects SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID EXPERIENCE; REPAIR C1 Brooke Army Med Ctr, Urol Serv, Ft Sam Houston, TX 78234 USA. RP Morey, AF (reprint author), Brooke Army Med Ctr, Urol Serv, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM allen.morey@cen.amedd.army.mil NR 2 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S41 EP S41 DI 10.1097/TA.0b013e318065428b PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600031 PM 17556964 ER PT J AU Murray, CK AF Murray, Clinton K. TI Infections in burns SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Murray, CK (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM clinton.murray@amedd.army.mil NR 0 TC 11 Z9 11 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S73 EP S73 DI 10.1097/TA.0b013e318065af1a PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600054 PM 17556989 ER PT J AU Renz, EM AF Renz, Evan M. TI Thermal injuries (0IF and 0EF) SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Renz, EM (reprint author), USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. EM evan.renz@amedd.army.mil NR 0 TC 3 Z9 3 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S22 EP S22 DI 10.1097/TA.0b013e3180653ecf PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600016 PM 17556948 ER PT J AU Soderdahl, DW AF Soderdahl, Douglas W. TI The current spectrum of battlefield urological injuries SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN C1 Brooke Army Med Ctr, Dept Army, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Def, Ft Sam Houston, TX 78234 USA. RP Soderdahl, DW (reprint author), Brooke Army Med Ctr, Dept Army, Ft Sam Houston, TX 78234 USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S42 EP S42 DI 10.1097/TA.0b013e31806542a0 PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600032 PM 17556965 ER PT J AU Welch, G AF Welch, Gary TI Methods of hemodynamic monitoring SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 12th Annual San Antonio Trauma Symposium CY SEP 19-21, 2006 CL San Antonio, TX SP Trauma Inst San Antonio Texas, USN ID CATHETERIZATION; THERAPY; SEPSIS C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Welch, G (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM gwwelch7@earthlink.net NR 5 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0022-5282 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD JUN PY 2007 VL 62 IS 6 SU S BP S109 EP S109 DI 10.1097/TA.0b013e318065b54a PG 1 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA 180ER UT WOS:000247345600081 PM 17556935 ER PT J AU Paquette, EL AF Paquette, Edmond L. TI Genitourinary trauma at a combat support hospital during operation Iraqi freedom: The impact of body armor SO JOURNAL OF UROLOGY LA English DT Article DE wounds and injuries; urogenital system; protective devices; war; nephrectomy ID UROGENITAL INJURIES; WAR INJURIES; EXPERIENCE; NEPHRECTOMY; PREDICTORS AB Purpose: This report details the occurrences of genitourinary trauma experienced during Operation Iraqi Freedom at a United States Army Combat Support Hospital, and determines if wearing body armor decreases the frequency of genitourinary and specifically kidney trauma. Materials and Methods: The Joint Theater Trauma Registry was used to conduct a retrospective study of 2,712 trauma admissions to a United States Army Combat Support Hospital in Baghdad, Iraq from April 1, 2005 to February 28, 2006. There were 1,216 casualties who were wearing body armor and 1,496 casualties not wearing body armor. Results: Of the 2,712 trauma admissions 76 (2.8%) had 1 or more genitourinary injuries for a total of 98 genitourinary injuries. Of the 29 kidney injuries 2 (6.9%) were explored without any treatment, 7 (24.1%) were observed, 1 (3.4%) was repaired and 19 (65.5%) casualties required nephrectomy. Casualties wearing body armor had a 2.1% rate of genitourinary injury versus 3.4% not wearing body armor (p = 0.037). Casualties wearing body armor had a 0.5% rate of kidney injury compared to 1.4% not wearing body armor (p = 0.017). Conclusions: The percentage of casualties with genitourinary injuries and the distribution of these injuries appear similar to previous conflicts. The percentage of casualties undergoing nephrectomy appears to be greater than that observed in other recent conflicts. There was a significant reduction in overall genitourinary injuries and specifically kidney injuries in those casualties wearing body armor. C1 Womack Army Med Ctr, Stop A, Urol Serv, Ft Bragg, NC 28310 USA. RP Paquette, EL (reprint author), Womack Army Med Ctr, Stop A, Urol Serv, 2817 Reilly Rd, Ft Bragg, NC 28310 USA. EM etpaquette@aol.com NR 18 TC 23 Z9 23 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 2007 VL 177 IS 6 BP 2196 EP 2199 DI 10.1016/j.juro.2007.01.132 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 170BJ UT WOS:000246635800043 PM 17509316 ER PT J AU Altamura, LA Bertolotti-Ciarlet, A Teigler, J Paragas, J Schmaljohn, CS Doms, RW AF Altamura, Louis A. Bertolotti-Ciarlet, Andrea Teigler, Jeffrey Paragas, Jason Schmaljohn, Connie S. Doms, Robert W. TI Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreG(N) that leads to generation of an NSM protein SO JOURNAL OF VIROLOGY LA English DT Article ID M-RNA; NUCLEOTIDE-SEQUENCE; NAIROVIRUS GENUS; MOVEMENT PROTEIN; GLYCOPROTEINS; LOCALIZATION; BUNYAVIRIDAE; SEGMENT; MORPHOGENESIS; ORGANIZATION AB The structural glycoproteins of Crimean-Congo hemorrhagic fever virus (CCHFV; genus Nairovirus, family Bunyaviridae) are derived through endoproteolytic cleavage of a 1,684-amino-acid M RNA segment-encoded polyprotein. This polyprotein is cotranslationally cleaved into the PreG(N) and PreG(C) precursors, which are then cleaved by SKI-1 and a SKI-1-like protease to generate the N termini of G(N) and G(C), respectively. However, the resulting polypeptide defined by the N termini of G(N) and G(C) is predicted to be larger (58 kDa) than mature GN (37 kDa). By analogy to the topologically similar M segment-encoded polyproteins of viruses in the Orthobunyavirus genus, the C-terminal region of PreG(N) that contains four predicted transmembrane domains may also contain a nonstructural protein, NSM. To characterize potential PreG(N) C-terminal cleavage events, a panel of epitope-tagged PreG(N) truncation and internal deletion mutants was developed. These constructs allowed for the identification of a C-terminal endoproteolytic cleavage within, or very proximal to, the second predicted transmembrane domain following the G(N) ectodomain and the subsequent generation of a C-terminal fragment. Pulse-chase experiments showed that PreG(N) C-terminal cleavage occurred shortly after synthesis of the precursor and prior to generation of the G(N) glycoprotein. The resulting fragment trafficked to the Golgi compartment, the site of virus assembly. Development of an antiserum specific to the second cytoplasmic loop of PreG(N) allowed detection of cell-associated NSM proteins derived from transient expression of the complete CCHFV M segment and also in the context of virus infection. C1 Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA. Ursinus Coll, Collegeville, PA 19426 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. RP Doms, RW (reprint author), Univ Penn, Dept Microbiol, 225 Johnson Pavil,3610 Hamilton Walk, Philadelphia, PA 19104 USA. EM doms@mail.med.upenn.edu RI Altamura, Louis/B-5668-2008 FU NIAID NIH HHS [T32 AI055400] NR 43 TC 34 Z9 37 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0022-538X J9 J VIROL JI J. Virol. PD JUN PY 2007 VL 81 IS 12 BP 6632 EP 6642 DI 10.1128/JVI.02730-06 PG 11 WC Virology SC Virology GA 175BP UT WOS:000246987500045 PM 17409136 ER PT J AU Fristachi, A Rice, G Steevens, J Linkov, I AF Fristachi, Anthony Rice, Glenn Steevens, Jeffery Linkov, Igor TI A preliminary exposure assessment of microcystins from consumption of drinking water in the United States SO LAKE AND RESERVOIR MANAGEMENT LA English DT Article; Proceedings Paper CT 25th International Symposium of the North-American-Lake-Management-Society CY NOV, 2005 CL Madison, WI SP N Amer Lake Management Soc DE cyanobacteria; cyanotoxins; exposure assessment; drinking water; harmful algal blooms ID LOGNORMAL DISTRIBUTIONS; SPRAY IRRIGATION; CYANOBACTERIA; SUPPLEMENTS; TOXINS; LAKE AB This preliminary human exposure assessment of cyanotoxins from consumption of treated drinking water in the United States is based on reported concentrations of microcystin-LR equivalents, (herein referred to as MC-LR), a cyanotoxin measured in a study of North American drinking waters conducted by the American Water Works Association from June 1996 to January 1998. The sampling protocol resulted in a distribution of MC-LR concentrations in waters that likely overestimates the actual distribution encountered by the exposed population, yielding conservatively biased estimates of exposure. Over a 75-year lifetime, the estimated lifetime average daily dose of MC-LR from the consumption of drinking water was estimated to be 1.7 x 10(-3) mu g/kg-day with a standard deviation of 0.02. The 90 and 95 percentile exposure estimates were 1.5 x 10(-1) and 3.9 x 10(-3), respectively. Our results suggest that most individuals are exposed to cyanotoxin levels in finished North American drinking waters that are approximately an order of magnitude lower than the World Health Organization's provisional guideline level of 1 mu g/L, which corresponds to approximately 0.04 mu g/kg-day. C1 [Fristachi, Anthony] US EPA, Oak Ridge Inst Sci & Educ, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA. [Steevens, Jeffery] USA, Corps Engineers, Ctr Res Dev & Engn, Vicksburg, MS 39180 USA. [Linkov, Igor] Intertox Inc, Brookline, MA USA. RP Fristachi, A (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Natl Ctr Environm Assessment, 26 W Martin Luther King Dr MS-A110, Cincinnati, OH 45268 USA. EM afristac@jhsph.edu NR 33 TC 1 Z9 1 U1 0 U2 5 PU NORTH AMER LAKE MANAGEMENT SOC PI MADISON PA PO BOX 5443, MADISON, WI 53705-5443 USA SN 1040-2381 J9 LAKE RESERV MANAGE JI Lake Reserv. Manag. PD JUN PY 2007 VL 23 IS 2 BP 203 EP 210 PG 8 WC Limnology; Marine & Freshwater Biology; Water Resources SC Marine & Freshwater Biology; Water Resources GA 333ON UT WOS:000258161900010 ER PT J AU Litz, M Feroli, T Merkel, GM Guardala, N Helba, M Pereira, NR Carroll, JJ AF Litz, M. Feroli, T. Merkel, G. M. Guardala, N. Helba, M. Pereira, N. R. Carroll, J. J. TI Evaluation of Ho-166m: In search of photonuclear cross sections and trigger-level paths SO LASER PHYSICS LA English DT Article ID DEFORMED-NUCLEI; TRANSITIONS AB Part of the Army Research Laboratory's battery program is research in the viability of nuclear batteries. Particularly attractive is a nuclear battery that can be stored without loss of energy, and then turned on by some external signal. This paper describes the progress toward that goal. C1 Army Res Lab, Adelphi, MD 20873 USA. Naval Surface Warfare Ctr, Carderock, MD USA. SRS Inc, Huntsville, AL USA. Ecopulse Inc, Springfield, VA USA. Youngstown State Univ, Youngstown, OH 44555 USA. RP Litz, M (reprint author), Army Res Lab, Adelphi, MD 20873 USA. NR 7 TC 1 Z9 1 U1 0 U2 2 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD JUN PY 2007 VL 17 IS 6 BP 868 EP 873 DI 10.1134/S1054660X07060138 PG 6 WC Optics; Physics, Applied SC Optics; Physics GA 181DJ UT WOS:000247416800013 ER PT J AU Pereira, NR Merkel, GM Litz, M AF Pereira, N. R. Merkel, G. M. Litz, M. TI Economics of isomeric energy SO LASER PHYSICS LA English DT Article ID HF-178M2; EMISSION; RAYS AB A high energy density source based on nuclear isomers may be conceptually attractive; but it is unrealistic if the energy's price is too excessive. This paper estimates the price of isomeric energy, and shows that isomers can become practical only for low-energy applications. C1 Ecopulse Inc, Springfield, VA 22152 USA. Army Res Lab, Adelphi, MD 20873 USA. RP Pereira, NR (reprint author), Ecopulse Inc, Springfield, VA 22152 USA. NR 15 TC 1 Z9 1 U1 0 U2 0 PU MAIK NAUKA/INTERPERIODICA/SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA SN 1054-660X J9 LASER PHYS JI Laser Phys. PD JUN PY 2007 VL 17 IS 6 BP 874 EP 879 DI 10.1134/S1054660X0706014X PG 6 WC Optics; Physics, Applied SC Optics; Physics GA 181DJ UT WOS:000247416800014 ER PT J AU Burgess, EB AF Burgess, Edwin B. TI Partners in command: George Marshall and Dwight Eisenhower in war and peace. SO LIBRARY JOURNAL LA English DT Book Review C1 USA Combined Arms Res Lib, Ft Leavenworth, KS USA. RP Burgess, EB (reprint author), USA Combined Arms Res Lib, Ft Leavenworth, KS USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU REED BUSINESS INFORMATION PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 1 PY 2007 VL 132 IS 10 BP 129 EP 129 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA 175KQ UT WOS:000247012900135 ER PT J AU Chang, T Tucker, J AF Chang, T. Tucker, J. TI A new method to perform CT gantry tilt angle quality control using commercially available phantom SO MEDICAL PHYSICS LA English DT Meeting Abstract CT 49th Annual Meeting of the American-Association-of-Physicists-in-Medicine CY JUL 22-26, 2007 CL Minneapolis, MN SP Amer Assoc Physicists Med C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0094-2405 J9 MED PHYS JI Med. Phys. PD JUN PY 2007 VL 34 IS 6 BP 2340 EP 2340 DI 10.1118/1.2760386 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 182BH UT WOS:000247479600101 ER PT J AU Wong, K Jung, M Maxwell, G Dritschilo, A AF Wong, K. Jung, M. Maxwell, G. Dritschilo, A. TI Dosimetry studies of GeneSeed therapy SO MEDICAL PHYSICS LA English DT Meeting Abstract CT 49th Annual Meeting of the American-Association-of-Physicists-in-Medicine CY JUL 22-26, 2007 CL Minneapolis, MN SP Amer Assoc Physicists Med C1 Georgetown Univ, Washington, DC USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0094-2405 J9 MED PHYS JI Med. Phys. PD JUN PY 2007 VL 34 IS 6 BP 2652 EP 2652 DI 10.1118/1.2761766 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA 182BH UT WOS:000247479601372 ER PT J AU Gonzalez, R Wilkerson, R Suarez, MF Garcia, F Gallego, G Cardenas, H Posso, CE Duque, MC AF Gonzalez, Ranulfo Wilkerson, Richard Suarez, Marco Fidel Garcia, Felipe Gallego, Gerardo Cardenas, Heiber Posso, Carmen Elisa Duque, Myriam Cristina TI A population genetics study of Anopheles darlingi (Diptera : Culicidae) from Colombia based on random amplified polymorphic DNA-polymerase chain reaction and amplified fragment lenght polymorphism markers SO MEMORIAS DO INSTITUTO OSWALDO CRUZ LA English DT Article DE amplified fragment length polymorphism; Anopheles darlingi; genetic diversity; malaria vectors; random amplified; polymorphic DNA; polymerase chain reaction; Colombia ID MALARIA VECTOR; ROOT; CHROMOSOMES; MOSQUITOS; DISTANCE; AMERICA; BRAZIL; PCR AB The genetic variation and population structure of three populations of Anopheles darlingi from Colombia were studied using random amplified polymorphic markers (RAPDs) and amplified fragment length polymorphism markers (AFLPs). Six RAPD primers produced 46 polymorphic fragments, while two AFLP primer combinations produced 197 polymorphic fragments from 71 DNA samples. Both of the evaluated genetic markers showed the presence of gene flow, suggesting that Colombian An. darlingi populations are in panmixia. Average genetic diversity, estimated from observed heterozygosity, was 0.374 ( RAPD) and 0.309 ( AFLP). RAPD and AFLP markers showed little evidence of geographic separation between eastern and western populations; however, the F-ST values showed high gene flow between the two western populations ( RAPD: F-ST = 0.029; Nm: 8.5; AFLP: F-ST = 0.051; Nm: 4.7). According to molecular variance analysis ( AMOVA), the genetic distance between populations was significant (RAPD: Phi(ST) = 0.084; AFLP: Phi(ST) = 0.229, P < 0.001). The FST distances and AMOVAs using AFLP loci support the differentiation of the Guyana biogeographic province population from those of the Choco-Magdalena. In this last region, Choco and Cordoba populations showed the highest genetic flow. C1 Univ Valle, Natl Program Sci & Technol Colciencias, Fac Ciencias, Cali, Colombia. Univ Valle, Natl Program Sci & Technol Colciencias, Fac Salud, Cali, Colombia. Walter Reed Army Inst Res, Dept Entomol, Silver Spring, MD USA. Int Ctr Trop Agr, Cali, Colombia. RP Gonzalez, R (reprint author), Univ Valle, Natl Program Sci & Technol Colciencias, Fac Ciencias, Code 1106-04-168-95, Cali, Colombia. EM ranulfo@univalle.edu.co NR 46 TC 9 Z9 9 U1 0 U2 5 PU FUNDACO OSWALDO CRUZ PI RIO DE JANEIRO, RJ PA AV BRASIL 4365, 21045-900 RIO DE JANEIRO, RJ, BRAZIL SN 0074-0276 J9 MEM I OSWALDO CRUZ JI Mem. Inst. Oswaldo Cruz PD JUN PY 2007 VL 102 IS 3 BP 255 EP 262 DI 10.1590/S0074-02762007005000037 PG 8 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA 189CE UT WOS:000247965700003 PM 17568929 ER PT J AU Tunick, A AF Tunick, A. TI Modeling microphysical influences on optical turbulence in complex areas SO METEOROLOGY AND ATMOSPHERIC PHYSICS LA English DT Article ID LASER-BEAM; SURFACE LAYER; FOREST; ATMOSPHERE; FLUCTUATIONS; SIMULATION; INDEX; WIND; FLOW AB An earlier paper showed that there is a growing need for increasingly accurate and reliable numerical models to predict optical turbulence conditions, especially in complex (nonuniform) signal propagation environments. Thus, we present a finite-difference computer model to demonstrate a viable approach for predicting the microphysical (microclimate) influences on optical turbulence intensity (C (2)(n)) around the ARL A_LOT Facility and its surroundings (which consist of multiple building arrays and forests). Our multi-dimensional prototype model begins to address optical turbulence conditions along more complex lines-of-sight and begins to account for inhomogeneities in C (2)(n) brought about by horizontal changes in landscape, wind flow, temperature, and humidity. For now, the model physics represent advection, pressure gradient, eddy diffusion, and vegetation drag force processes. Simple mechanisms to predict the heat and moisture source terms have also been incorporated. Initial model results have been quite encouraging. The model code is computationally efficient and extremely flexible with regard to modifications and debugging. We anticipate that this kind of computational research will be an important vehicle for investigating C (2)(n) and related laser-optic propagation effects in complex areas. C1 USA, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA. RP Tunick, A (reprint author), USA, Res Lab, Computat & Informat Sci Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM atunick@arl.army.mil NR 36 TC 9 Z9 9 U1 0 U2 2 PU SPRINGER WIEN PI WIEN PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA SN 0177-7971 EI 1436-5065 J9 METEOROL ATMOS PHYS JI Meteorol. Atmos. Phys. PD JUN PY 2007 VL 96 IS 3-4 BP 293 EP 304 DI 10.1007/s00703-006-0215-6 PG 12 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA 181IK UT WOS:000247430200009 ER PT J AU Brou, DG AF Brou, Deirdre G. TI Alternatives to the judicially promulgated Feres doctrine SO MILITARY LAW REVIEW LA English DT Article C1 USA, Legal Serv Agcy, Litigat Div, Torts Law Branch, Arlington, VA USA. RP Brou, DG (reprint author), USA, Legal Serv Agcy, Litigat Div, Torts Law Branch, Arlington, VA USA. NR 0 TC 3 Z9 3 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 USA SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 2007 VL 192 BP 1 EP 80 PG 80 WC Law SC Government & Law GA 237UP UT WOS:000251402200001 ER PT J AU Stetz, MC Castro, CA Bliese, PD AF Stetz, Melba C. Castro, Carl A. Bliese, Paul D. TI The impact of deactivation uncertainty, workload, and organizational constraints on reservists' psychological well-being and turnover intentions SO MILITARY MEDICINE LA English DT Article ID JOB-SATISFACTION; ARMY RESERVE; STRESS; COMBAT; HEALTH; DUTY; WAR AB This study assessed the impact of the activation of U.S. Army reservists after terrorists attacked the United States on September 11, 2001. A total of 263 soldiers completed a survey and participated in focus groups. The model's stressors were deactivation uncertainty, workload, and organizational constraints. The outcomes were well-being and turnover intentions. In general, most stressors did predict the proposed outcomes. That is, with high deactivation uncertainty, workload, or organizational constraints, reservists reported low psychological well-being and high turnover intentions. Commanders and policymakers can use our findings when addressing ways to improve reservists' psychological health and to decrease turnover intentions. Specifically, reservists need more predictability and the needed organizational conditions (i.e., proper workload levels and equipment) while activated and deployed to protect our country. C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. USA, Med Res Unit Europe, D-69126 Heidelberg, Germany. RP Stetz, MC (reprint author), USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. NR 35 TC 9 Z9 10 U1 2 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2007 VL 172 IS 6 BP 576 EP 580 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 178PV UT WOS:000247233500005 PM 17615835 ER PT J AU Ivins, BJ Schwab, KA Crowley, JS McEntire, BJ Trumble, CC Brown, FH Warden, DL AF Ivins, Brian J. Schwab, Karen A. Crowley, John S. McEntire, B. Joseph Trumble, Christopher C. Brown, Fred H., Jr. Warden, Deborah L. TI How satisfied are soldiers with their ballistic helmets? A comparison of soldiers' opinions about the advanced combat helmet and the personal armor system for ground troops helmet SO MILITARY MEDICINE LA English DT Article AB Many factors are considered during ballistic helmet design, including comfort, weight, fit, and maintainability. These factors affect soldiers' decisions about helmet use; therefore, rigorous research about soldiers' real-life experiences with helmets is critical to assessing a helmet's overall protective efficacy. This study compared soldiers' satisfaction and problem experience with the advanced combat helmet (ACH) and the personal armor system for ground troops (PASGT) helmet. Data were obtained from surveys of soldiers at Fort Bragg, North Carolina. Ninety percent of ACH users were satisfied overall with their helmet, but only 9.5% of PASGT users were satisfied (p < 0.001). The most frequently reported problems for the ACH involved malfunctioning helmet parts. The most frequently reported problems for the PASGT involved discomfort. This analysis indicated that there was a strong soldier preference for the ACH over the PASGT, which could enhance its already superior protective qualities. It also demonstrated the usefulness of soldiers' assessments of protective equipment. C1 Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. USA, Combat Readiness Ctr, Air Task Force, Ft Rucker, AL 36362 USA. USA, Special Operat Command, Psychol Operat Directorate, Ft Bragg, NC 28310 USA. RP Ivins, BJ (reprint author), Walter Reed Army Med Ctr, Def & Vet Brain Injury Ctr, Washington, DC 20307 USA. NR 5 TC 6 Z9 6 U1 0 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2007 VL 172 IS 6 BP 586 EP 591 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA 178PV UT WOS:000247233500007 PM 17615837 ER PT J AU Beekley, MD Alt, J Buckley, CM Duffey, M Crowder, TA AF Beekley, Matthew D. Alt, Jonathan Buckley, Clyde M. Duffey, Michael Crowder, Todd A. TI Effects of heavy load carriage during constant-speed, simulated, road marching SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 51st Annual Meeting of the American-College-of-Sports-Medicine CY JUN 02-05, 2004 CL Indianapolis, IN SP Amer Coll Sports Med ID MEDICAL ASPECTS AB Load carriage is a key element in dismounted military operations. Load carriage requirements in the field regularly exceed 50% of lean body mass (LBM) and have only rarely been studied. Therefore, our purpose was to determine the metabolic and motivational effects of heavy loads (30-70% LBM) during constant-rate "road" marching on a treadmill. Ten healthy male Army officers carried loads of 30%, 50%, and 70% LBM in an all-purpose, lightweight, individual, carrying equipment pack for 30 minutes, at a speed of 6 km/h. Oxygen consumption ((V) over dot O-2), ventilation, heart rate (HR), respiratory exchange ratio, rating of perceived exertion (RPE), and Self-Motivation Inventory scores were recorded at each trial. Significant increases were observed for (V) over dot O-2, ventilation, and HR between the trials. RPE significantly increased for the 70% LBM trial, compared with the 30% and 50% trials. No significant differences were seen in respiratory exchange ratio or Self-Motivation Inventory scores. Increasingly heavy loads carried in a rucksack resulted in increased (V) over dot O-2, RPE, and HR; therefore, increasing the load that a soldier is required to carry may negatively affect road march performance. C1 US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. RP Beekley, MD (reprint author), US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA. NR 10 TC 34 Z9 36 U1 1 U2 11 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2007 VL 172 IS 6 BP 592 EP 595 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 178PV UT WOS:000247233500008 PM 17615838 ER PT J AU Crowder, TA Beekley, MD Sturdivant, RX Johnson, CA Lumpkin, A AF Crowder, Todd A. Beekley, Matthew D. Sturdivant, Rodney X. Johnson, Christopher A. Lumpkin, Angela TI Metabolic effects of soldier performance on a simulated graded road march while wearing two functionally equivalent military ensembles SO MILITARY MEDICINE LA English DT Article; Proceedings Paper CT 52nd Annual Meeting of the American-College-of-Sports-Medicine CY JUN 01-04, 2005 CL Nashville, TN SP Amer Coll Sports Med ID ENERGY-EXPENDITURE; PHYSICAL-FITNESS; LOAD CARRIAGE; WALKING; INJURIES; DOWNHILL AB Objectives: The purpose of this study was to examine metabolic effects of soldier performance on a simulated road march, comparing two functionally equivalent military ensembles (FEMEs) with changing gradation of marching, and to create prediction equations addressing workload with different loads and treadmill grades. Methods: Fourteen male military subjects were tested while wearing two different FEMEs on a graded (0%, 5%, or 10%), 3.5 miles/h, road march for 30 minutes. Data collected included oxygen uptake (VO2), carbon dioxide output, ventilation, respiratory exchange ratio, and heart rate (HR). Results: No significant differences were found between the two FEMEs in each graded condition. Combining ensemble data, significant differences occurred in all conditions, comparing all grades. A 10% graded road march (3.5 miles/h, similar to 27-kg load) represented 61% to 90% of maximal values. For treadmill grades of < 10%, VO2 and HR were modeled as follows (adjusted R-2 = 0.89 [VO2] and 0.82 (HR]): VO2 (mL/kg per minute) = 10 + [2 . grade (%)] + [0.2 . load (% of body mass)]; HR (beats per minute) = 90 + [6 . grade (%)] + [0.7 . load (% of body mass)]. Conclusions: Three factors, namely, elevation grade, equipment weight (load), and overall subject physical abilities, were significant for overall metabolic demand during a simulated graded road march and might affect field performance. C1 US Mil Acad, West Point, NY 10996 USA. Univ Kansas, Sch Educ, Lawrence, KS 66045 USA. RP Crowder, TA (reprint author), US Mil Acad, West Point, NY 10996 USA. NR 22 TC 7 Z9 7 U1 0 U2 6 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2007 VL 172 IS 6 BP 596 EP 602 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA 178PV UT WOS:000247233500009 PM 17615839 ER PT J AU Lam, DM Fecura, SE AF Lam, David M. Fecura, Stephen E., Jr. TI The trauma continuum-of-care quality forum integration committee system-wide video teleconference SO MILITARY MEDICINE LA English DT Article AB The lessons learned in the care of combat casualties throughout time have been vitally important to the improvement of military medicine. However, often the lessons learned were essentially personal, because the ability to transmit those lessons to other medical personnel was not systematized and organized. In past wars, the transmission of those lessons to other care providers was difficult and often long after the fact. Consultant visits were made and War Medicine conferences were held, but policy changes and actual changes in the mechanisms to provide care often lagged. Lessons learned often were not widely spread until years later. New capabilities in medical communications have permitted the development of real-time casualty care information exchange and rapid policy decision-making. This article describes one such effort. C1 USA, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. Univ Maryland, Sch Med, Charles McC Mathias Natl Study Ctr Trauma & Emerg, Baltimore, MD 21201 USA. USAF, Sch Aerosp Med, Crit Care Air Transport Team Course, Brooks AFB, TX 78235 USA. RP Lam, DM (reprint author), USA, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA. NR 15 TC 6 Z9 6 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2007 VL 172 IS 6 BP 611 EP 615 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA 178PV UT WOS:000247233500012 PM 17615842 ER PT J AU Carmichael, MG AF Carmichael, Mark G. TI Central nervous system anaplastic large cell lymphoma in an adult: Successful treatment with a combination of radiation and chemotherapy SO MILITARY MEDICINE LA English DT Article ID EXPRESSION AB Anaplastic large cell lymphoma (ALCL) is 1 of 17 mature T cell neoplasms described by the World Health Organization. Primary central nervous system (PCNS) ALCL represents a distinct rare form of this family of non-Hodgkin lymphoma and discussions of prognosis and management are limited to case reports and case series. Therapies for this disease largely parallel that of other PCNS lymphomas. We report the case of a 38-year-old male soldier who presented with a parieto-occipital mass lesion and neurological sequelae without evidence of systemic disease. Pathologic evaluation of tissue from brain biopsy confirmed ALCL. We elected treatment with an intensive combination of systemic and intrathecal chemotherapy with radiotherapy. Our patient is in complete remission 15 months following therapy. Tailored therapies for PCNS ALCL are unavailable and this regimen may be an option for patients who can tolerate intensive treatments. C1 Walter Reed Army Med Ctr, Hematol & Oncol Serv, Washington, DC 20307 USA. RP Carmichael, MG (reprint author), Walter Reed Army Med Ctr, Hematol & Oncol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. NR 13 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 2007 VL 172 IS 6 BP 673 EP 675 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA 178PV UT WOS:000247233500027 PM 17615857 ER PT J AU Schell, MA Ulrich, RL Ribot, WJ Brueggemann, EE Hines, HB Chen, D Lipscomb, L Kim, HS Mrazek, J Nierman, WC DeShazer, D AF Schell, Mark A. Ulrich, Ricky L. Ribot, Wilson J. Brueggemann, Ernst E. Hines, Harry B. Chen, Dan Lipscomb, Lyla Kim, H. Stanley Mrazek, Jan Nierman, William C. DeShazer, David TI Type VI secretion is a major virulence determinant in Burkholderia mallei SO MOLECULAR MICROBIOLOGY LA English DT Article ID ACTIN-BASED MOTILITY; PROTEIN SECRETION; PSEUDOMONAS-AERUGINOSA; PATHOGENICITY ISLAND; EDWARDSIELLA-TARDA; BACTERIAL GENOMES; ESCHERICHIA-COLI; EUKARYOTIC CELLS; SYSTEM; GLANDERS AB Burkholderia mallei is a host-adapted pathogen and a category B biothreat agent. Although the B. mallei VirAG two-component regulatory system is required for virulence in hamsters, the virulence genes it regulates are unknown. Here we show with expression profiling that overexpression of virAG resulted in transcriptional activation of similar to 60 genes, including some involved in capsule production, actin-based intracellular motility, and type VI secretion (T6S). The 15 genes encoding the major sugar component of the homopolymeric capsule were up-expressed > 2.5-fold, but capsule was still produced in the absence of virAG. Actin tail formation required virAG as well as bimB, bimC and bimE, three previously uncharacterized genes that were activated four- to 15-fold when VirAG was overproduced. Surprisingly, actin polymerization was found to be dispensable for virulence in hamsters. In contrast, genes encoding a T6S system were up-expressed as much as 30-fold and mutations in this T6S gene cluster resulted in strains that were avirulent in hamsters. SDS-PAGE and mass spectrometry demonstrated that BMAA0742 was secreted by the T6S system when virAG was overexpressed. Purified His-tagged BMAA0742 was recognized by glanders antiserum from a horse, a human and mice, indicating that this Hcp-family protein is produced in vivo during infection. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. Univ Georgia, Dept Microbiol, Athens, GA 30602 USA. Inst Genom Res, Rockville, MD 20850 USA. Korea Univ, Coll Med, Seoul 136701, South Korea. RP DeShazer, D (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. EM deshazer@amedd.army.mil FU NIAID NIH HHS [1-R21-AI069081, Y1-AI-5004-01] NR 67 TC 193 Z9 205 U1 3 U2 28 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD JUN PY 2007 VL 64 IS 6 BP 1466 EP 1485 DI 10.1111/j.1365-2958.2007.05734.x PG 20 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 177TP UT WOS:000247175700006 PM 17555434 ER PT J AU Hill, SC Chowdhury, DQ AF Hill, Steven C. Chowdhury, Dipakbin Q. TI Microphotonics - Toroid of many colours SO NATURE PHYSICS LA English DT News Item ID GENERATION; RESONANCES; EXCITATION; DROPLETS; FIBER AB A demonstration of continuous sum-frequency generation of visible light in a microscopic silica resonator could provide a light source for on-chip silicon photonics and applications in the UV. C1 USA, Res Lab, Adelphi, MD 20783 USA. Corning Inc, Div Sci & Technol, Corning, NY 14831 USA. RP Hill, SC (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM shill@arl.army.mil; chowdhurdq@corning.com NR 11 TC 0 Z9 0 U1 2 U2 4 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 1745-2473 J9 NAT PHYS JI Nat. Phys. PD JUN PY 2007 VL 3 IS 6 BP 378 EP 379 DI 10.1038/nphys638 PG 2 WC Physics, Multidisciplinary SC Physics GA 180EF UT WOS:000247344400010 ER PT J AU Andreas, EL Wang, S AF Andreas, Edgar L. Wang, Sinny TI Predicting significant wave height off the northeast coast of the United States SO OCEAN ENGINEERING LA English DT Article DE buoy data; fully developed sea; ocean waves; significant wave height; wave modeling ID AIR-SEA FLUXES; BULK PARAMETERIZATION; SPRAY; VERIFICATION; OCEAN AB To develop a simple method to predict the significant wave height, we analyze 18 years of hourly observations from 12 different buoys that are off the northeast coast of the United States. Water depths ranged from 19 to 4427 in for these moored buoys. We find that, on average, all of these buoys exhibit a region of constant wave height for 10-m wind speeds between 0 and 4m s(-1). That wave height does, however, depend on water depth. For wind speeds above 4 in s-1, the wave height increases as the square of the wind speed; but the multiplicative factor is again a function of water depth. We synthesize these results in a prediction scheme that yields the significant wave height from simple functions of water depth and 10-m wind speed for wind speeds up to 25 in s(-1). Published by Elsevier Ltd. C1 USA, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Dartmouth Coll, Hanover, NH 03755 USA. RP Andreas, EL (reprint author), USA, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA. EM eandreas@nwra.com NR 21 TC 20 Z9 22 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD JUN PY 2007 VL 34 IS 8-9 BP 1328 EP 1335 DI 10.1016/j.oceaneng.2006.08.004 PG 8 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA 177JF UT WOS:000247148700023 ER PT J AU Knuteson, DJ Singh, NB Gottlieb, M Suhre, D Gupta, N Berghmans, AE Kahler, DA Wagner, B Hawkins, J AF Knuteson, David J. Singh, Narsingh B. Gottlieb, Milton Suhre, Dennis Gupta, Neelam Berghmans, Andre E. Kahler, David A. Wagner, Brian Hawkins, Jack TI Crystal growth, fabrication, and design of mercurous bromide acousto-optic tunable filters SO OPTICAL ENGINEERING LA English DT Article DE AOTF; nonlinear optics; acousto-optic tunable filter; acousto-optic imaging; mercurous bromide ID CHLORIDE SINGLE-CRYSTALS AB Device-quality single crystals of mercurous bromide were grown by the physical vapor transport method. Crystals transmitted light wavelengths up to 30 mu m and did not show any absorption bands. Detailed x-ray Laue and x-ray diffraction studies were used to characterize and orient the crystals. Optical evaluation was performed by fabricating slabs of crystals. A design was developed to fabricate acousto-optic tunable filters with 10-deg off-axis orientation operating in the mid- and long-wavelength regions. An acousto-optic tunable filter (AOTF) was fabricated using a crystal with a 16-mm optical aperture for the 10-deg design. A theoretical tuning curve for a mercurous bromide crystal-based AOTF using this design was also computed for the first time. Experimentally measured data on frequency matching agreed well with the theoretical predictions, and the transducer thickness was suitable for filtering 7.58 mu m with the fabricated AOTF. (C) 2007 Society of Photo-Optical Instrumentation Engineers. C1 Northrop Grumman Corp, Linthicum, MD 21090 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Knuteson, DJ (reprint author), Northrop Grumman Corp, ES,1212 Winterson Rd, Linthicum, MD 21090 USA. EM nb.singh@ngc.com RI Gupta, Neelam/B-8702-2013 NR 6 TC 10 Z9 11 U1 0 U2 1 PU SPIE-SOCIETY PHOTOPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUN PY 2007 VL 46 IS 6 AR 064001 DI 10.1117/1.2744369 PG 6 WC Optics SC Optics GA 186XX UT WOS:000247813000008 ER PT J AU Khanna, PC Ponsky, T Zagol, B Lukish, JR Markle, BM AF Khanna, Paritosh C. Ponsky, Todd Zagol, Bradley Lukish, Jeffrey R. Markle, Bruce M. TI Sonographic appearance of canal of Nuck hydrocele SO PEDIATRIC RADIOLOGY LA English DT Article DE patent processus vaginalis; canal of Nuck; cyst; hydrocele; sonography; adolescent ID ULTRASOUND; CYST; RARE AB We present a case of a relatively uncommon entity in a 17-year-old girl who presented to the emergency department with right inguinal pain and discomfort. On sonography, she was thought to have a hydrocele of a patent processus vaginalis, although differentials could not be excluded. The hydrocele was subsequently confirmed at surgery. Because this is an uncommonly reported condition, a high index of suspicion must be maintained in the appropriate clinical setting. We present various sonographic appearances and techniques that have been proposed in the literature. C1 George Washington Univ, Dept Diagnost Imaging & Radiol, Childrens Natl Med Ctr, Washington, DC USA. George Washington Univ, Dept Pediat Surg, Childrens Natl Med Ctr, Washington, DC USA. Walter Reed Army Med Ctr, Dept Gen Surg, Washington, DC 20307 USA. RP Khanna, PC (reprint author), 3805 Fremont Ave N,Apt 401, Seattle, WA 98103 USA. EM paritoshkhanna@hotmail.com RI Ponsky, Todd/J-1214-2014 OI Ponsky, Todd/0000-0001-7195-1493 NR 8 TC 13 Z9 13 U1 0 U2 1 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD JUN PY 2007 VL 37 IS 6 BP 603 EP 606 DI 10.1007/s00247-007-0481-6 PG 4 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA 166EB UT WOS:000246359500018 PM 17453186 ER PT J AU Scalora, M de Ceglia, D D'Aguanno, G Mattiucci, N Akozbek, N Centini, M Bloemer, MJ AF Scalora, Michael de Ceglia, Domenico D'Aguanno, Giuseppe Mattiucci, Nadia Akozbek, Neset Centini, Marco Bloemer, Mark J. TI Gap solitons in a nonlinear quadratic negative-index cavity SO PHYSICAL REVIEW E LA English DT Article ID 2ND-HARMONIC GENERATION; OPTICAL FIBERS; FOCUS ISSUE; PROPAGATION; REFRACTION; METAMATERIALS; PULSES AB We predict the existence of gap solitons in a nonlinear, quadratic Fabry-Perot negative index cavity. A peculiarity of a single negative index layer is that if magnetic and electric plasma frequencies are different it forms a photonic band structure similar to that of a multilayer stack composed of ordinary, positive index materials. This similarity also results in comparable field localization and enhancement properties that under appropriate conditions may be used to either dynamically shift the band edge, or for efficient energy conversion. We thus report that an intense, fundamental pump pulse is able to shift the band edge of a negative index cavity, and make it possible for a weak second harmonic pulse initially tuned inside the gap to be transmitted, giving rise to a gap soliton. The process is due to cascading, a well-known phenomenon that occurs far from phase matching conditions that limits energy conversion rates, it resembles a nonlinear third-order process, and causes pulse compression due to self-phase modulation. The symmetry of the equations of motion under the action of either an electric or a magnetic nonlinearity suggests that both nonlinear polarization and magnetization, or a combination of both, can lead to solitonlike pulses. More specifically, the antisymmetric localization properties of the electric and magnetic fields cause a nonlinear polarization to generate a dark soliton, while a nonlinear magnetization spawns a bright soliton. C1 USA, RDECOM, AMSRD AMR WS ST, Charles M Bowden Res Facil, Redstone Arsenal, AL 35898 USA. Politecn Bari, Dipartimento Elettrotecn & Elettron, I-70124 Bari, Italy. Time Domain Corp, Huntsville, AL 35806 USA. Univ Roma La Sapienza, Dipartimento Energet, INFM, I-00161 Rome, Italy. RP Scalora, M (reprint author), USA, RDECOM, AMSRD AMR WS ST, Charles M Bowden Res Facil, Redstone Arsenal, AL 35898 USA. OI D'Aguanno, Giuseppe/0000-0002-7132-0103; CENTINI, MARCO/0000-0003-0625-0054 NR 32 TC 13 Z9 13 U1 0 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1539-3755 J9 PHYS REV E JI Phys. Rev. E PD JUN PY 2007 VL 75 IS 6 AR 066606 DI 10.1103/PhysRevE.75.066606 PN 2 PG 6 WC Physics, Fluids & Plasmas; Physics, Mathematical SC Physics GA 184EO UT WOS:000247624100064 PM 17677375 ER PT J AU Jarrett, EM Yee, BWK Banks, ME AF Jarrett, Erica M. Yee, Barbara W. K. Banks, Martha E. TI Benefits of comprehensive health care for improving health outcomes in women SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Article DE Health Care for the Whole Person; health psychology; primary care psychology; women's health; women's health psychology ID DOMESTIC VIOLENCE; DEPRESSION; PSYCHOLOGISTS; INTERVENTIONS; PREVALENCE; SETTINGS; DECADE AB The American Psychological Association Health Care for the Whole Person Task Force was formulated to provide a rationale for integrating behavioral health services in primary care. Collectively, the task force called for a transformation of the biomedical system into one based on the biopsychosocial model. This article is a summary of the Women's Health Committee position paper that reviewed contextual factors in women's health, provided recommendations for clinical service action, and recommended an integrated primary health care system to address women's health needs. This article provides a vision of integrated care and a practical guide for psychology practitioners as they collaborate with other health care providers and health policy groups to improve health outcomes for women over the life course. C1 Walter Reed Army Med Ctr, Gen Internal Med Clin, Primary Care Psychol Serv, Washington, DC 20307 USA. Univ Hawaii Manoa, Honolulu, HI 96822 USA. ABackans DCP Inc, Div Res & Dev, Akron, OH USA. RP Jarrett, EM (reprint author), Walter Reed Army Med Ctr, Gen Internal Med Clin, Primary Care Psychol Serv, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM erica.jarrett@na.amedd.army.mil OI Banks, Martha/0000-0002-5367-2076 NR 71 TC 4 Z9 4 U1 1 U2 1 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD JUN PY 2007 VL 38 IS 3 BP 305 EP 313 DI 10.1037/0735-7028.38.3.305 PG 9 WC Psychology, Multidisciplinary SC Psychology GA 173UU UT WOS:000246898800011 ER PT J AU Lemmon, KM Stafford, EM AF Lemmon, Keith M. Stafford, Elisabeth M. TI Recognizing and responding to child and adolescent stress: The critical role of the pediatrician SO PSYCHIATRIC ANNALS LA English DT Article ID PSYCHOSOCIAL PROBLEMS; MILITARY FAMILIES; MENTAL-HEALTH; PRIMARY-CARE; MORBIDITY C1 Brooke Army Med Ctr, Div Adolescent Med, USA, Med Corps, Ft Sam Houston, TX 78234 USA. Univ Texas San Antonio, San Antonio, TX 78285 USA. RP Lemmon, KM (reprint author), Brooke Army Med Ctr, Div Adolescent Med, USA, Med Corps, Bldg 3600,3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM Keith.Lemmon@us.army.mil NR 23 TC 2 Z9 2 U1 1 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0048-5713 EI 1938-2456 J9 PSYCHIAT ANN JI Psychiatr. Ann. PD JUN PY 2007 VL 37 IS 6 BP 431 EP + PG 11 WC Psychiatry SC Psychiatry GA 179YQ UT WOS:000247327000010 ER PT J AU Nelson, A Press, N Bautista, CT Arevalo, J Calderon, M Campos, K Bryant, A Shantz-Dunn, J Dahodwala, N Vera, M Vivar, A Saito, M Gilman, RH AF Nelson, Amy Press, Natasha Bautista, Christian T. Arevalo, Jorge Calderon, Maritza Campos, Kalina Bryant, Amy Shantz-Dunn, Julianna Dahodwala, Nabila Vera, Mario Vivar, Aldo Saito, Mayuko Gilman, Robert H. TI Prevalence of sexually transmitted infections and high-risk sexual Behaviors in heterosexual couples attending sexually transmitted disease clinics in Peru SO SEXUALLY TRANSMITTED DISEASES LA English DT Article ID UREAPLASMA-UREALYTICUM; CHLAMYDIAL INFECTIONS; TRICHOMONAS-VAGINALIS; MYCOPLASMA-GENITALIUM; TREPONEMA-PALLIDUM; HIV TRANSMISSION; PCR; WORKERS; WOMEN; MEN AB Objectives: The objectives of this study were to determine the prevalence of sexually transmitted infection (STIs) in heterosexual couples and the sexual behaviors associated with their acquisition. Goal: The goal of this study was to better direct educational efforts to decrease STI among heterosexual couples in Lima, Peru. Study Design: We conducted a case-control study in 195 heterosexual couples without HIV infection who attended 2 sexually transmitted disease clinics in Lima, Peru. A case was defined as an individual with one or more newly diagnosed STIs such as gonorrhea, chlamydia, trichomoniasis, herpes simplex, syphilis, mycoplasma, or ureaplasma. Results: Thirty-three percent of individuals (41 men and 89 women) had at least one STI and 26 couples (13%) had the same STI detected. Men who have sex with men (MSM) accounted for 13% of all men, had higher rate of STIs and higher risk behaviors than non-MSM. Ureaplasma infection was the most prevalent STI found in both men and women and was associated with oral sexual contact. In heterosexual pairs, condom use during anal sex occurred less than 10% of the time. Conclusions: The heterosexual couples in sexually transmitted disease clinics have high-risk behaviors and STIs are frequent. The educational effort concerning prevention of STIs requires higher effort. C1 Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA. Thomas Jefferson Univ Hosp, Dept Obstet & Gynecol, Philadelphia, PA 19107 USA. Univ British Columbia, Div Infect Dis, Vancouver, BC V5Z 1M9, Canada. Henry M Jackson Fdn Adv Mil Med Inc, US Mil HIV Res Program, Walter Reed Army Inst Res, Rockville, MD USA. Hosp Dos De Mayo, Dept Infect Dis, Lima, Peru. Arzobispo Loayza Hosp, Lima, Peru. Asoc Benef Proyectos Informat Salud Med & Agr, AB PRISMA, Lima, Peru. Univ Peruana Cayetano Heredia, Dept Pathol, Lima, Peru. Saga Univ, Sch Med, Dept Gen Internal Med, Saga 840, Japan. RP Gilman, RH (reprint author), Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Int Hlth, 615 N Wolfe St,Room W5515, Baltimore, MD 21205 USA. EM rgilman@jhsph.edu RI Bautista, Christian/B-2812-2011 FU FIC NIH HHS [D43 TW006581]; NIAID NIH HHS [T35AI007646] NR 36 TC 6 Z9 6 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0148-5717 J9 SEX TRANSM DIS JI Sex. Transm. Dis. PD JUN PY 2007 VL 34 IS 6 BP 344 EP 361 DI 10.1097/01.olq.0000240341.95087.da PG 18 WC Infectious Diseases SC Infectious Diseases GA 172DF UT WOS:000246783600005 PM 17075438 ER PT J AU Tieu, B Sondeen, J Shults, C Holcomb, J Alam, H Schreiber, M AF Tieu, B. Sondeen, J. Shults, C. Holcomb, J. Alam, H. Schreiber, M. TI Reproducibility of a complex hemorrhagic shock model and tissue injury in swine at three academic research centers SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 Oregon Hlth & Sci Univ, Portland, OR 97239 USA. USA, Inst Surg Res, San Antonio, TX USA. Harvard Univ, Sch Med, Boston, MA 02114 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 24 EP 25 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700075 ER PT J AU Salinas, J Cancio, L Kramer, G Wade, C Drew, G Holcomb, J Wolf, S AF Salinas, J. Cancio, L. Kramer, G. Wade, C. Drew, G. Holcomb, J. Wolf, S. TI Development of decision-assist algorithm for burn resuscitation SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 29 EP 29 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700087 ER PT J AU Dubick, MA Prince, MD Medina, L Sondeen, JL AF Dubick, M. A. Prince, M. D. Medina, L. Sondeen, J. L. TI Effects of select antioxidants on efficacy of resuscitation with lactated Ringer's (LR) in a swine model of severe hemorrhage (HEM) SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 38 EP 38 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700116 ER PT J AU Sondeen, J Prince, M Medina, L Holcomb, J Dubick, M AF Sondeen, J. Prince, M. Medina, L. Holcomb, J. Dubick, M. TI Comparison of fresh whole blood (FWB), FWB and factor VIIa (rFVIIa), and component therapy (RBC plus FFP) to normal saline (NS) given as intravascular hemostatic agents (IVA) to cold, coagulopathic swine with uncontrolled liver hemorrhage SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 38 EP 39 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700118 ER PT J AU Gorbunov, NV Das, DK Atkins, JL AF Gorbunov, N. V. Das, D. K. Atkins, J. L. TI Redox signaling and inflammatory remodeling in microvascular endothelium following shock wave - Induced pulmonary trauma SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 Walter Reed Army Inst Res, Cardiovasc Res Ctr, Silver Spring, MD 20910 USA. Univ Connecticut, Sch Med, Farmington, CT 06030 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 41 EP 41 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700127 ER PT J AU Chung, K Wolf, S Barillo, D Park, M Blackbourne, L Horvath, E Albrecht, M White, C Wanek, S Renz, E Cancio, L Wade, C Holcomb, J AF Chung, K. Wolf, S. Barillo, D. Park, M. Blackbourne, L. Horvath, E. Albrecht, M. White, C. Wanek, S. Renz, E. Cancio, L. Wade, C. Holcomb, J. TI Impact of high-volume hemofiltation in burn patients who develop circulatory shock SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 45 EP 45 PG 1 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700139 ER PT J AU Martini, W Chinkesl, D Terrazas, I Colvin, S Taylor, K Black, I AF Martini, W. Chinkesl, D. Terrazas, I. Colvin, S. Taylor, K. Black, I. TI Effects of severe hemorrhage on coagulation and fibrinogen kinetics in pigs SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 USA, Inst Surg Res, Galveston, TX USA. Univ Texas, Med Branch, Galveston, TX 77550 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 55 EP 56 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700173 ER PT J AU Torres, A Bentley, T Bartels, J Puyana, JC Vodovotz, Y AF Torres, A. Bentley, T. Bartels, J. Puyana, J. C. Vodovotz, Y. TI Characterization of inflammatory response to hemorrhagic shock in mice using an automated, closed-loop system SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 Univ Pittsburgh, Pittsburgh, PA 15213 USA. Walter Reed Army Inst Res, Silver Spring, MD 20910 USA. Immunetrics Inc, Pittsburgh, PA USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 58 EP 59 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700182 ER PT J AU Wade, C Salinas, J Eastridge, B McManus, J Holcomb, J AF Wade, C. Salinas, J. Eastridge, B. McManus, J. Holcomb, J. TI Admission hypo- or hyperthermia adversely affects survival after traumatic injury: A comparison of combat and civilian casualties SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 67 EP 68 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700210 ER PT J AU Uwaydah, N Hoskins, S Bruttig, S Copper, N Deyo, D Farrar, H Dubick, M Kramer, G AF Uwaydah, N. Hoskins, S. Bruttig, S. Copper, N. Deyo, D. Farrar, H. Dubick, M. Kramer, G. TI Delivery of nerve agent antidote 2-PAM-Cl using intramuscular (IM) and intraosseous (IO) administration in swine SO SHOCK LA English DT Meeting Abstract CT 30th Annual Conference of the Shock-Society CY JUN 09-12, 2007 CL Baltimore, MD SP Shock Soc C1 Univ Texas, Med Branch, Resuscitat Res Lab, Galveston, TX 77550 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1073-2322 J9 SHOCK JI Shock PD JUN PY 2007 VL 27 SU 1 BP 82 EP 83 PG 2 WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System & Cardiology GA 173PT UT WOS:000246885700258 ER PT J AU Busby, RR Torbert, HA Gebhart, DL AF Busby, Ryan R. Torbert, H. Allen Gebhart, Dick L. TI Carbon and nitrogen mineralization of non-composted and composted municipal solid waste in sandy soils SO SOIL BIOLOGY & BIOCHEMISTRY LA English DT Article; Proceedings Paper CT 2nd General Annual Conference of the European-Geosciences-Union CY APR 24-29, 2005 CL Vienna, AUSTRIA SP European Geosci Union DE municipal waste; compost; carbon mineralization; nitrogen mineralization; soil organic matter ID RAPA VAR PERVIDIS; REFUSE COMPOST; ORGANIC-MATTER; NEUBAUER POT; MATURITY; GROWTH; SUCCESSION; STABILITY; CO2 AB A sterilized, but undecomposed, organic by-product of municipal waste processing was incubated in sandy soils to compare C and N mineralization with mature municipal waste compost. Waste products were added to two soils at rates of 17.9, 35.8, 71.6, and 143 Mg ha(-1) dry weight and incubated at 25 degrees C for 90 d. Every 30 d, nitrate and ammonium concentrations were analyzed and C mineralization was measured as total CO2-C evolved and added total organic C. Carbon mineralization of the undecomposed waste decreased over time, was directly related to application rate and soil nutrient status, and was significantly higher than C mineralization of the compost, in which C evolution was relatively unaffected across time, soils, and application rates. Carbon mineralization, measured as percentage C added by the wastes, also indicated no differences between composted waste treatments. However, mineralization as a percentage of C added in the undecomposed waste treatments was inversely related to application rate in the more productive soil, and no rate differences were observed in the highly degraded soil. Total inorganic N concentrations were much higher in the compost- and un-amended soils than in unclecomposed waste treatments. Significant N immobilization occurred in all undecomposed waste treatments. Because C mineralization of the undecomposed waste was dependant on soil nutrient status and led to significant immobilization of N, this material appears to be best suited for highly degraded soils low in organic matter where restoration of vegetation adapted to nutrient poor soils is desired Published by Elsevier Ltd. C1 USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA. USDA, ARS, Natl Soil Dynam Lab, Auburn, AL 36832 USA. RP Busby, RR (reprint author), USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, POB 9005, Champaign, IL 61826 USA. EM ryan.r.busby@erdc.usacc.army.mil NR 30 TC 34 Z9 35 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0038-0717 J9 SOIL BIOL BIOCHEM JI Soil Biol. Biochem. PD JUN PY 2007 VL 39 IS 6 BP 1277 EP 1283 DI 10.1016/j.soilbio.2006.12.003 PG 7 WC Soil Science SC Agriculture GA 161FL UT WOS:000245999800004 ER PT J AU Hong, HP Wright, B Wensel, J Jin, SH Ye, XR Roy, W AF Hong, Haiping Wright, Brian Wensel, Jesse Jin, Sungho Ye, Xiang Rong Roy, Walter TI Enhanced thermal conductivity by the magnetic field in heat transfer nanofluids containing carbon nanotube SO SYNTHETIC METALS LA English DT Article DE thermal conductivity; carbon nanotube; nanofluids; magnetic field AB In this paper, we report for the first time that the thermal conductivity (TC) of the heat transfer nanofluids could be enhanced by the external magnetic field. The heat transfer nanofluids contain carbon nanotubes (CNTs) and magnetic-field-sensitive nanoparticles of Fe(2)O(3). The reasonable explanation for these interesting results is that the Fe(2)O(3) particles form aligned chains under applied magnetic field and help to connect the nanotubes, which results in improved thermal conductivity. On longer holding in magnetic field, the particles gradually move and form large clumps of particles, causing clumping of CNTs, then decreasing the TC. We also found that the time to reach the maximum peak value of TC is increased as the applied magnetic field is reduced by increasing the gap between two magnets. Scanning electron microscopy (SEM) pictures show that the nanotubes and nanoparticle are aligned well under the influence of magnetic field. (c) 2007 Elsevier B.V. All rights reserved. C1 S Dakota Sch Mines & Technol, Dept Met Mat Engn, Rapid City, SD 57701 USA. Univ Calif San Diego, Dept Mech & Aerospace Engn, La Jolla, CA 92093 USA. Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP Hong, HP (reprint author), S Dakota Sch Mines & Technol, Dept Met Mat Engn, Rapid City, SD 57701 USA. EM Haiping.Hong@sdsmt.edu NR 10 TC 48 Z9 50 U1 0 U2 17 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0379-6779 J9 SYNTHETIC MET JI Synth. Met. PD JUN PY 2007 VL 157 IS 10-12 BP 437 EP 440 DI 10.1016/j.synthmet.2007.05.009 PG 4 WC Materials Science, Multidisciplinary; Physics, Condensed Matter; Polymer Science SC Materials Science; Physics; Polymer Science GA 210QI UT WOS:000249470300006 ER PT J AU Meade, K Lam, DM AF Meade, Kenneth Lam, David M. TI A deployable telemedicine capability in support of humanitarian operations SO TELEMEDICINE JOURNAL AND E-HEALTH LA English DT Article AB This paper describes how a military concept for telemedicine support in humanitarian crisis, the Medical Command, Control, Communication and Telemedicine Special Medical Augmentation Team (MC3T SMART TEAM), was transitioned from a theoretical concept into a functioning, operational entity. The European Regional Medical Command (ERMC) MC3T SMART TEAM successfully tested its capabilities during a military training exercise with the 212th mobile army surgical hospital ( MASH). This was followed by successful real-life telemedicine support missions during a planned humanitarian support mission in Africa and then an emergency disaster support mission in Pakistan. While on these missions, the SMART team provided access to the Internet and e-mail by means of limited bandwidth mobile satellite equipment, established a working telemedicine process by introducing the staff to the United States Army's "Army Knowledge Online (AKO) Remote Consultation Program," and established a successful connection of the 212th's digital radiography system to the " Tri-Service Global Encrypted Picture Archiving and Communication System ( PACS) and Teleradiology Network." C1 Landstuhl Reg Med Ctr, Landstuhl, Germany. RP Lam, DM (reprint author), USA, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA. EM LAM@TATRC.ORG NR 9 TC 14 Z9 14 U1 0 U2 2 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-5627 J9 TELEMED J E-HEALTH JI Telemed. J. e-Health PD JUN PY 2007 VL 13 IS 3 BP 331 EP 340 DI 10.1089/tmj.2006.0040 PG 10 WC Health Care Sciences & Services SC Health Care Sciences & Services GA 186TB UT WOS:000247800000026 PM 17603836 ER PT J AU Cavallaro, PV Sadegh, AM Quigley, CJ AF Cavallaro, Paul V. Sadegh, Ali M. Quigley, Claudia J. TI Decrimping behavior of uncoated plain-woven fabrics subjected to combined biaxial tension and shear stresses SO TEXTILE RESEARCH JOURNAL LA English DT Article ID MECHANICS AB Tension structures continue to be of increasing importance to military applications requiring minimal weight, small packaging volumes and enhanced deployment operations. Presently, design methods for inflated fabric structures are not well established. Analysis tools for their efficient design lag behind those for conventional structures, partly because woven fabrics do not behave as a continuum. Changes in fabric architecture occur with loading and lead to several sources of nonlinear response. In particular effective constitutive relationships must be developed that institute the combined effects of biaxial tensile stresses from inflation and shear stresses from bending for use in structural models. Through analysis and experiment, this study addressed these architectural changes, such as crimp inter-change, and their effects on the mechanical properties of uncoated plain-woven fabrics. This was accomplished through meso-scale finite element analyses and material tests using a recently developed experimental fixture. The fixture facilitated testing of a wide variety of fabrics (woven, braided, knitted, etc) subjected to combined biaxial tensile and shear stresses. The meso-scale models and swatch level test results confirmed that (1) crimp interchange profoundly influenced the fabric elastic and shear striffnesses, as changes in crimp heights occurred with increasing biaxial tensions (2) the shear modulus was highly dependent upon the biaxial tensions and compaction of the tows at the crossover points and (3) the shear modulus was highly nonlinear and was not monotonic with rotation and shear force. This study also presents analytical and experimental methods to ascertain the elastic and shear moduli of woven fabrics for use in evaluating the performance of air beams. C1 Naval Undersea Warfare Ctr Div Newport, Mech Adv Struct & Mat Team, Newport, RI 02841 USA. CUNY, Dept Mech Engn, New York, NY 10031 USA. USA, Natick Solider Res Dev & Engn Ctr, Natick, MA 01760 USA. RP Cavallaro, PV (reprint author), Naval Undersea Warfare Ctr Div Newport, Mech Adv Struct & Mat Team, Newport, RI 02841 USA. EM cavallaropov@npt.nuwc.navy.mil NR 15 TC 16 Z9 16 U1 3 U2 10 PU SAGE PUBLICATIONS LTD PI LONDON PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND SN 0040-5175 J9 TEXT RES J JI Text. Res. J. PD JUN PY 2007 VL 77 IS 6 BP 403 EP 416 DI 10.1177/0040517507080258 PG 14 WC Materials Science, Textiles SC Materials Science GA 232PW UT WOS:000251032600006 ER PT J AU Koff, SG Paquette, EL Cullen, J Gancarczyk, KK Tucclarone, PR Schenkman, NS AF Koff, Stacey G. Paquette, Edmond L. Cullen, Jenny Gancarczyk, Kevin K. Tucclarone, Paulette R. Schenkman, Noah S. TI Comparison between lemonade and potassium citrate and impact on urine pH and 24-hour urine parameters in patients with kidney stone formation SO UROLOGY LA English DT Article ID HYPOCITRATURIC CALCIUM NEPHROLITHIASIS; RENAL CALCULI AB Objectives The past few decades have been notable for advances in minimally invasive techniques to treat kidney stones. Despite successful surgical managernent of calculi, the impact of diet on stone disease prevention remains an important factor. Dietary modifications can be applied to prevent stone recurrence in an economical manner that is acceptable to patients. Lemonade has been Studied in the past and found to increase urinary citrate levels in small groups of patients. The present Study examined the effect of lemonade intake on a change in urinary PH and improvement Of urinary stone risk factors compared with potassium citrate treatment. Methods A total of 21 stone-forming patients were treated with lemonade therapy and potassium citrate Supplementation in a prospective cross-over trial. We performed 24-hour urine collections at baseline and with each treatment arm. The results between the two groups were examined to determine whether differences existed in the urinary stone risk factors. Results Potassium citrate, but not lemonade, improved citrate levels and urinary PH to a significant degree. Patients taking potassium citrate had a significantly decreased urine volume compared with their Urine Volume drinking lemonade. Neither lemonade nor potassium citrate affected the uric acid levels to a significant degree. Conclusions The results of our study have shown that lemonade did not provide improvements in urinary citrate or PH levels but did assist patients in maintaining Urine Output compared with potassium citrate therapy. C1 Walter Reed Army Med Ctr, Ctr Prostate Dis Res, Washington, DC 20307 USA. RP Koff, SG (reprint author), Dept Surg, Serv Urol, 6900 Georgia Ave,NW, Washington, DC 20307 USA. EM stacey.koff@ma.ameedd.mil NR 12 TC 31 Z9 33 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0090-4295 J9 UROLOGY JI Urology PD JUN PY 2007 VL 69 IS 6 BP 1013 EP 1016 DI 10.1016/j.urology.2007.02.008 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA 188KC UT WOS:000247917800001 PM 17572176 ER PT J AU Mores, CN Turell, MJ Dohm, DJ Blow, JA Carranza, MT Quintana, M AF Mores, Christopher N. Turell, Michael J. Dohm, David J. Blow, Jamie A. Carranza, Marco T. Quintana, Miguel TI Experimental transmission of West Nile virus by Culex nigripalpus from Honduras SO VECTOR-BORNE AND ZOONOTIC DISEASES LA English DT Article DE Culex nigripalpus; West Nile virus; vector competence; Honduras ID VALLEY FEVER VIRUS; VECTOR COMPETENCE; EXPERIMENTAL-INFECTION; MOSQUITOS DIPTERA; ENCEPHALITIS; CULICIDAE; PIPIENS; BIRDS AB As a result of concerns regarding the geographic spread of West Nile virus (WNV) to Central America, we evaluated the potential for Honduran Culex nigripalpus Theobald to transmit this virus. We tested individual mosquitoes captured in Olancho Province, Honduras, in September 2003. Mosquitoes were allowed to feed on 2- to 4-day-old chickens previously inoculated with a New York strain (Crow 397-99) of WNV. Infection rates in Cx. nigripalpus ranged from 81%-96% after feeding on chickens with viremias between 10(6.3) and 10(7.4) plaque-forming units per milliliter. Development of a disseminated infection was directly correlated with holding time after the infectious blood meal as 68% (19/28) of the mosquitoes tested 20 days after the infectious blood meal had a disseminated infection as compared to 38% (15/40) of the mosquitoes tested 14 days after feeding on the same viremic chickens (viremia = 10(6.9-7.1)). Nearly all (4/5) Cx. nigripalpus with a disseminated infection that fed on susceptible chickens transmitted virus by bite. In addition, 8 (57%) of 14 Cx. nigripalpus with a disseminated infection transmitted virus when tested by a capillary tube feeding assay. Based on its efficiency of viral transmission in this study and its role in the transmission of the closely related St. Louis encephalitis virus in the southeastern United States, Cx. nigripalpus should be considered a potentially important vector of WNV in Honduras and the rest of Central America. C1 USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. USA, Entomol Sci Div, Ctr Hlth Promot & Prevent Med W, Ft Lewis, WA USA. RP Turell, MJ (reprint author), USA, Div Virol, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. EM michael-turell@det.amedd.army.mil NR 19 TC 12 Z9 12 U1 0 U2 4 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1530-3667 J9 VECTOR-BORNE ZOONOT JI Vector-Borne Zoonotic Dis. PD SUM PY 2007 VL 7 IS 2 BP 279 EP 284 DI 10.1089/vbz.2006.0557 PG 6 WC Public, Environmental & Occupational Health; Infectious Diseases SC Public, Environmental & Occupational Health; Infectious Diseases GA 193SH UT WOS:000248294100023 PM 17627449 ER PT J AU Han, ZY Licata, JM Paragas, J Harty, RN AF Han, Ziying Licata, Jillian M. Paragas, Jason Harty, Ronald N. TI Permeabilization of the plasma membrane by Ebola virus GP2 SO VIRUS GENES LA English DT Article DE Ebola virus; GP2; glycoprotein; hygromycin-B; permeabilization ID ESCHERICHIA-COLI-CELLS; ENDOPLASMIC-RETICULUM; INFECTED-CELLS; PORE FORMATION; COILED-COIL; PROTEINS 2B; GLYCOPROTEIN; ROTAVIRUS; DOMAIN; NSP4 AB The glycoprotein (GP) of Ebola virus (EBOV) is a multifunctional protein known to play a role in virus attachment and entry, cell rounding and cytotoxicity, down-regulation of host surface proteins, and enhancement of virus assembly and budding. EBOV GP is synthesized as a precursor which is subsequently cleaved to yield two disulfide-linked subunits: GP1 (surface-exposed [SU] subunit) and GP2 (membrane-anchored [TM] subunit). We sought to determine the effect of membrane-anchored GP2 protein expression on the integrity of host cell lipid membranes. Our findings indicated that: (i) expression of GP2 enhanced membrane permeability to hygromycin-B (hyg-B), (ii) the transmembrane (TM) domain of GP2 was essential for enhanced membrane permeability, (iii) amino acids (aa) 667ALF669 within the TM region of GP2 were important for enhanced membrane permeability, and (iv) EBOV infected cells were more permeable to hyg-B than mock infected cells. Together, these data suggest that the TM region of GP2 modifies the permeability of the plasma membrane. These findings may have important implications for GP-induced cell damage and pathogenesis of EBOV infection. C1 Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA. USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA. RP Harty, RN (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, 3800 Spruce St, Philadelphia, PA 19104 USA. EM rharty@vet.upenn.edu FU NIAID NIH HHS [AI46499] NR 46 TC 9 Z9 10 U1 2 U2 5 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-8569 J9 VIRUS GENES JI Virus Genes PD JUN PY 2007 VL 34 IS 3 BP 273 EP 281 DI 10.1007/s11262-006-0009-4 PG 9 WC Genetics & Heredity; Virology SC Genetics & Heredity; Virology GA 149WJ UT WOS:000245177300005 PM 16927113 ER PT J AU McGowan, CP Catlan, DH Jons, GD Pavelka, GA AF McGowan, Conor P. Catlan, Daniel H. Jons, Galen D. Pavelka, Gregory A. TI Piping plovers nesting amongst cottonwood saplings SO WATERBIRDS LA English DT Article DE breeding habitat; charadrius melodus; habitat plasticity; piping plover AB Piping Plovers (Charadrius melodus) typically nest on unvegetated sand or gravel substrates throughout their breeding range. We report on the atypical habitat characteristics of four Piping Plover nests that we found amongst young cottonwood (Populus deltoides) saplings on a sandbar island in the Missouri River along the South Dakota-Nebraska border. Atypical habitat use could have implications for estimating demographic parameters and management of this protected species. It is important to explore the extent to which Piping Plovers use atypical breeding habitat throughout their range and the quality of this potentially poor habitat. C1 Univ Missouri, Dept Fisheries & Wildlife, Columbia, MO 65211 USA. Virginia Polytech Inst & State Univ, Dept Fisheries & Wildlife Sci, Blacksburg, VA 24061 USA. USA, Corps Engineers, Yankton, SD 57078 USA. RP McGowan, CP (reprint author), Univ Missouri, Dept Fisheries & Wildlife, 302 Anheuser Busch Nat Resources Bldg, Columbia, MO 65211 USA. EM cpm4h9@rnissouri.edu NR 10 TC 0 Z9 0 U1 0 U2 2 PU WATERBIRD SOC PI WASHINGTON PA NATL MUSEUM NATURAL HISTORY SMITHSONIAN INST, WASHINGTON, DC 20560 USA SN 1524-4695 EI 1938-5390 J9 WATERBIRDS JI Waterbirds PD JUN PY 2007 VL 30 IS 2 BP 275 EP 277 DI 10.1675/1524-4695(2007)30[275:PPNACS]2.0.CO;2 PG 3 WC Ornithology SC Zoology GA 191KN UT WOS:000248130200014 ER PT J AU Adams, BD Hurtado, TR Geracci, J AF Adams, Bruce D. Hurtado, Timothy R. Geracci, James TI Improvised airway management devices SO WILDERNESS & ENVIRONMENTAL MEDICINE LA English DT Letter ID LAST DITCH AIRWAY C1 Brooke Army Med Ctr, Emergency Med Serv, San Antonio, TX USA. 121st Combat Support Hosp, Dept Emergency Med, Yongsan, South Korea. Eisenhower Army Med Ctr, Dept Family Med, Augusta, GA USA. RP Adams, BD (reprint author), Brooke Army Med Ctr, Emergency Med Serv, San Antonio, TX USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 USA SN 1080-6032 J9 WILD ENVIRON MED JI Wildern. Environ. Med. PD SUM PY 2007 VL 18 IS 2 BP 146 EP 147 DI 10.1580/06-WEME-LE-074.1 PG 2 WC Public, Environmental & Occupational Health; Sport Sciences SC Public, Environmental & Occupational Health; Sport Sciences GA 184KU UT WOS:000247641100013 ER PT J AU Sampath, R Russell, KL Massire, C Eshoo, MW Harpin, V Blyn, LB Melton, R Ivy, C Pennella, T Li, F Levene, H Hall, TA Libby, B Fan, N Walcott, DJ Ranken, R Pear, M Schink, A Gutierrez, J Drader, J Moore, D Metzgar, D Addington, L Rothman, R Gaydos, CA Yang, S St George, K Fuschino, ME Dean, AB Stallknecht, DE Goekjian, G Yingst, S Monteville, M Saad, MD Whitehouse, CA Baldwin, C Rudnick, KH Hofstadler, SA Lemon, SM Ecker, DJ AF Sampath, Rangarajan Russell, Kevin L. Massire, Christian Eshoo, Mark W. Harpin, Vanessa Blyn, Lawrence B. Melton, Rachael Ivy, Cristina Pennella, Thuy Li, Feng Levene, Harold Hall, Thomas A. Libby, Brian Fan, Nancy Walcott, Demetrius J. Ranken, Raymond Pear, Michael Schink, Amy Gutierrez, Jose Drader, Jared Moore, David Metzgar, David Addington, Lynda Rothman, Richard Gaydos, Charlotte A. Yang, Samuel St. George, Kirsten Fuschino, Meghan E. Dean, Amy B. Stallknecht, David E. Goekjian, Ginger Yingst, Samuel Monteville, Marshall Saad, Magdi D. Whitehouse, Chris A. Baldwin, Carson Rudnick, Karl H. Hofstadler, Steven A. Lemon, Stanley M. Ecker, David J. TI Global Surveillance of Emerging Influenza Virus Genotypes by Mass Spectrometry SO PLOS ONE LA English DT Article AB Background. Effective influenza surveillance requires new methods capable of rapid and inexpensive genomic analysis of evolving viral species for pandemic preparedness, to understand the evolution of circulating viral species, and for vaccine strain selection. We have developed one such approach based on previously described broad-range reverse transcription PCR/electrospray ionization mass spectrometry (RT-PCR/ESI-MS) technology. Methods and Principal Findings. Analysis of base compositions of RT-PCR amplicons from influenza core gene segments (PB1, PB2, PA, M, NS, NP) are used to provide subspecies identification and infer influenza virus H and N subtypes. Using this approach, we detected and correctly identified 92 mammalian and avian influenza isolates, representing 30 different H and N types, including 29 avian H5N1 isolates. Further, direct analysis of 656 human clinical respiratory specimens collected over a seven-year period (1999-2006) showed correct identification of the viral species and subtypes with >97% sensitivity and specificity. Base composition derived clusters inferred from this analysis showed 100% concordance to previously established clades. Ongoing surveillance of samples from the recent influenza virus seasons (2005-2006) showed evidence for emergence and establishment of new genotypes of circulating H3N2 strains worldwide. Mixed viral quasispecies were found in approximately 1% of these recent samples providing a view into viral evolution. Conclusion/Significance. Thus, rapid RT-PCR/ESI-MS analysis can be used to simultaneously identify all species of influenza viruses with clade-level resolution, identify mixed viral populations and monitor global spread and emergence of novel viral genotypes. This high-throughput method promises to become an integral component of influenza surveillance. C1 [Sampath, Rangarajan; Massire, Christian; Eshoo, Mark W.; Harpin, Vanessa; Blyn, Lawrence B.; Melton, Rachael; Ivy, Cristina; Pennella, Thuy; Li, Feng; Levene, Harold; Hall, Thomas A.; Libby, Brian; Fan, Nancy; Walcott, Demetrius J.; Ranken, Raymond; Pear, Michael; Schink, Amy; Gutierrez, Jose; Drader, Jared; Moore, David; Hofstadler, Steven A.; Ecker, David J.] Ibis Biosci Inc, Carlsbad, CA USA. [Russell, Kevin L.; Metzgar, David; Addington, Lynda] USN, Hlth Res Ctr, Resp Dis Lab, San Diego, CA 92152 USA. [Rothman, Richard; Gaydos, Charlotte A.; Yang, Samuel] Johns Hopkins Med Inst, Dept Emergency Med & Med, Baltimore, MD 21205 USA. [St. George, Kirsten; Fuschino, Meghan E.; Dean, Amy B.] New York State Dept Hlth, Wadsworth Ctr, Albany, NY USA. [Stallknecht, David E.; Goekjian, Ginger] Univ Georgia, Coll Vet Med, Athens, GA USA. [Yingst, Samuel; Monteville, Marshall; Saad, Magdi D.] Naval Med Res Unit 3, Cairo, Egypt. [Whitehouse, Chris A.; Baldwin, Carson] USA, Ft Detrick, MD USA. [Rudnick, Karl H.] Sci Applicat Int Corp, San Diego, CA 92121 USA. [Lemon, Stanley M.] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX USA. RP Sampath, R (reprint author), Ibis Biosci Inc, Carlsbad, CA USA. EM rsampath@ibisbio.com RI Gaydos, Charlotte/E-9937-2010; Saad, Magdi/H-5561-2013; Valle, Ruben/A-7512-2013; OI Saad, Magdi/0000-0003-2111-8115; Rothman, Richard/0000-0002-1017-9505 FU DARPA; U.S. Department of Defense; CDC [R01-CI-000099]; NIAID, NIH [IUCIAI067232-01] FX The RT-PCR/ESI-MS technology development was funded by DARPA, a division of the U.S. Department of Defense. Funding from the CDC and NIAID supported the influenza surveillance assay development and screening described here. The sponsors had no role in the design, implementation or conlusions of the assay.; The author thank the CDC (Extramural Grant: R01-CI-000099) and NIAID (NIH Grant IUCIAI067232-01) for financial support. NR 26 TC 87 Z9 92 U1 1 U2 7 PU PUBLIC LIBRARY SCIENCE PI SAN FRANCISCO PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA SN 1932-6203 J9 PLOS ONE JI PLoS One PD MAY 30 PY 2007 VL 2 IS 5 AR e489 DI 10.1371/journal.pone.0000489 PG 9 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA V10FB UT WOS:000207448800019 PM 17534439 ER PT J AU Costanzo, PJ Beyer, FL AF Costanzo, Philip J. Beyer, Frederick L. TI Thermally driven assembly of nanoparticles in polymer matrices SO MACROMOLECULES LA English DT Article ID IN-SITU POLYMERIZATION; DIBLOCK COPOLYMER; POLY(METHYL METHACRYLATE); BLOCK-COPOLYMERS; BLENDS; NANOCOMPOSITES; COMPOSITES; BEHAVIOR; MORPHOLOGIES; ORGANIZATION AB Thermally responsive bulk polymer films utilizing reversible Diels-Alder chemistry have been developed. Gold nanoparticles (AuNPs) were passivated with thiol-terminated poly(styrene)-b-poly(ethylene glycol) (PS-b-PEG) copolymer ligand, where the PS and PEG blocks are joined via a Diels-Alder (DA) linkage. The ligand-functionalized nanoparticles were dispersed within a microphase-separated PS-b-poly(methyl methacrylate) (PS-b-PMMA) block copolymer. Nanoparticle location was dictated by the compatibility of the external shell with the block copolymer matrix. As cast, the PEG shell compatibilized the nanoparticles with the PMMA domains. Subsequent thermal treatment caused the Diels-Alder linkages between the polymer blocks to dissociate, leaving the AuNPs functionalized by PS ligands. Immiscibility within the PMMA matrix caused AuNP migration to the PS domains. Migration of the Au nanoparticles was determined using morphological characterization via small-angle X-ray scattering (SAXS) and cross-sectional transmission electron microscopy (TEM). C1 USA, Res Lab, Mat Div, Aberdeen Proving Ground, MD USA. RP Beyer, FL (reprint author), ARL, WM, MA, AMSRD, Bldg 4600, Aberdeen Proving Ground, MD 21005 USA. EM flbeyer@arl.army.mil RI Costanzo, Philip/E-8879-2011 OI Costanzo, Philip/0000-0001-6220-463X NR 32 TC 38 Z9 38 U1 3 U2 38 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAY 29 PY 2007 VL 40 IS 11 BP 3996 EP 4001 DI 10.1021/ma070447t PG 6 WC Polymer Science SC Polymer Science GA 170DZ UT WOS:000246643600017 ER PT J AU Gao, X Ray, R Xiao, Y Barker, PE Ray, P AF Gao, Xiugong Ray, Radharaman Xiao, Yan Barker, Peter E. Ray, Prabhati TI Inhibition of sulfur mustard-induced cytotoxicity and inflammation by the macrolide antibiotic roxithromycin in human respiratory epithelial cells SO BMC CELL BIOLOGY LA English DT Article ID NITRIC-OXIDE SYNTHASE; IN-VIVO; CYTOKINE; KERATINOCYTES; INTERLEUKIN-6; MACROPHAGES; MODULATION; EXPRESSION; VITRO; ASSAY AB Background: Sulfur mustard (SM) is a potent chemical vesicant warfare agent that remains a significant military and civilian threat. Inhalation of SM gas causes airway inflammation and injury. In recent years, there has been increasing evidence of the effectiveness of macrolide antibiotics in treating chronic airway inflammatory diseases. In this study, the anti-cytotoxic and anti-inflammatory effects of a representative macrolide antibiotic, roxithromycin, were tested in vitro using SM-exposed normal human small airway epithelial (SAE) cells and bronchial/tracheal epithelial (BTE) cells. Cell viability, expression of proinflammatory cytokines including interleukin (IL)-1 beta, IL-6, IL-8 and tumor necrosis factor (TNF), and expression of inducible nitric oxide synthase (iNOS) were examined, since these proinflammatory cytokines/mediators are import indicators of tissue inflammatory responses. We suggest that the influence of roxithromycin on SM-induced inflammatory reaction could play an important therapeutic role in the cytotoxicity exerted by this toxicant. Results: MTS assay and Calcein AM/ethidium homodimer (EthD-1) fluorescence staining showed that roxithromycin decreased SM cytotoxicity in both SAE and BTE cells. Also, roxithromycin inhibited the SM-stimulated overproduction of the proinflammatory cytokines IL-1 beta, IL-6, IL-8 and TNF at both the protein level and the mRNA level, as measured by either enzyme-linked immunosorbent assay (ELISA) or real-time RT-PCR. In addition, roxithromycin inhibited the SM-induced overexpression of iNOS, as revealed by immunocytochemical analysis using quantum dots as the fluorophore. Conclusion: The present study demonstrates that roxithromycin has inhibitory effects on the cytotoxicity and inflammation provoked by SM in human respiratory epithelial cells. The decreased cytotoxicity in roxithromycin-treated cells likely depends on the ability of the macrolide to down-regulate the production of proinflammatory cytokines and/or mediators. The results obtained in this study suggest that macrolide antibiotics may serve as potential vesicant respiratory therapeutics through mechanisms independent of their antibacterial activity. C1 Walter Reed Army Inst Res, Dept Biol, Div Expt Therapeut, Mol Biol Sect, Silver Spring, MD 20910 USA. USA, Med Res Inst Chem Def, Cell & Mol Biol Branch, Div Res, Aberdeen Proving Ground, MD 21010 USA. Natl Inst Stand & Technol, DNA Measurements Grp, Chem Sci & Technol Lab, Gaithersburg, MD 20899 USA. RP Ray, P (reprint author), Walter Reed Army Inst Res, Dept Biol, Div Expt Therapeut, Mol Biol Sect, Silver Spring, MD 20910 USA. EM xiugong.gao@na.amedd.army.mil; radharaman.ray@us.army.mil; yan.xiao@nist.gov; peter.barker@nist.gov; prabhati.ray@us.army.mil NR 33 TC 27 Z9 27 U1 0 U2 6 PU BIOMED CENTRAL LTD PI LONDON PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND SN 1471-2121 J9 BMC CELL BIOL JI BMC Cell Biol. PD MAY 24 PY 2007 VL 8 AR 17 DI 10.1186/1471-2121-8-17 PG 9 WC Cell Biology SC Cell Biology GA 177HY UT WOS:000247145400001 PM 17524151 ER PT J AU Xu, K Lam, YF Zhang, SS Jow, TR Curtis, TB AF Xu, Kang Lam, Yiufai Zhang, Sheng S. Jow, T. Richard Curtis, Timothy B. TI Solvation sheath of Li+ in nonaqueous electrolytes and its implication of graphite/electrolyte interface chemistry SO JOURNAL OF PHYSICAL CHEMISTRY C LA English DT Article ID IONIZATION-MASS-SPECTROSCOPY; UNDERSTAND SURFACE-CHEMISTRY; LITHIUM-ION BATTERIES; CARBON ANODES; GRAPHITE; ETHYLENE; DICARBONATE; REDUCTION; PRODUCT AB The formation chemistry of graphite/electrolyte interface and its dependence on electrolyte bulk composition were investigated by conducting electrochemical impedance analyses on interfaces systematically formed in various electrolytes and NMR identification of surface species harvested therefrom. The interpretation of these analyses strongly suggests that Li+ solvation sheath structure is central in defining the anode surface chemistry, because solvent molecules preferentially recruited by Li+ into the solvation sheath would be preferentially reduced on graphene surface upon initial charge of the electrode. Due to the preference of Li+ in binding the more polar molecules from the electrolyte solvent mixture, the contributions from cyclic and linear carbonates to the interface chemistry are unsymmetrical, and ethylene carbonate, the universal cosolvent in all electrolyte formulations, consequently becomes the favored chemical source for the interfacial ingredients. Since the chemical composition of the interface dictates Li+ transport kinetics at low temperatures, the understandings about how the electrolyte cosolvents share the responsibility for the graphite/electrolyte interfacial chemistry will benefit the efforts to tailor an interface that is more tolerant toward the operation of Li ion devices at sub-zero temperatures. C1 USA, Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. Univ Maryland, Dept Chem & Biochem, Adelphi, MD 20783 USA. RP Xu, K (reprint author), USA, Res Lab, Electrochem Branch, Sensor & Electron Devices Directorate, Adelphi, MD 20783 USA. EM cxu@arl.army.mil RI Zhang, Sheng/A-4456-2012; Xu, Kang/C-6054-2013 OI Zhang, Sheng/0000-0003-4435-4110; NR 25 TC 79 Z9 80 U1 8 U2 69 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1932-7447 J9 J PHYS CHEM C JI J. Phys. Chem. C PD MAY 24 PY 2007 VL 111 IS 20 BP 7411 EP 7421 DI 10.1021/jp068691u PG 11 WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary SC Chemistry; Science & Technology - Other Topics; Materials Science GA 169CH UT WOS:000246569800026 ER PT J AU Chretien, JP Fukuda, M Noedl, H AF Chretien, Jean-Paul Fukuda, Mark Noedl, Harald TI Improving surveillance for antimalarial drug resistance SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID MALARIA; ARTEMISININ; MUTATIONS; EFFICACY C1 US Dept Def, Global Emerging Infect Surveillance & Response Sy, Silver Spring, MD 20910 USA. Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand. Med Univ Vienna, Dept Specif Prophylaxis & Trop Med, Vienna, Austria. RP Chretien, JP (reprint author), US Dept Def, Global Emerging Infect Surveillance & Response Sy, 2900 Linden Lane, Silver Spring, MD 20910 USA. EM jean-paul.chretien@na.amedd.army.mil OI Chretien, Jean-Paul/0000-0001-8143-6823 NR 23 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 23 PY 2007 VL 297 IS 20 BP 2278 EP 2281 DI 10.1001/jama.297.20.2278 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA 170JM UT WOS:000246659700027 PM 17522014 ER PT J AU Joseph, KR Difazio, MP Hartman, KR Ney, JP AF Joseph, Kevin R. Difazio, Marc P. Hartman, Kip R. Ney, John P. TI Neurocutaneous melanosis associated with autoimmune diabetes mellitus SO NEUROLOGY LA English DT Editorial Material ID GAD C1 Madigan Army Med Ctr, Child Neurol Sect, Tacoma, WA 98431 USA. Madigan Army Med Ctr, Neurol Serv, Tacoma, WA 98431 USA. Capital Neurol, Olney, MD USA. Walter Reed Army Med Ctr, Pediat Hematol Oncol Serv, Washington, DC 20307 USA. RP Joseph, KR (reprint author), 12426 147th PL SE, Renton, WA 98059 USA. EM krjoseph1@hotmail.com NR 7 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAY 22 PY 2007 VL 68 IS 21 BP 1862 EP 1863 DI 10.1212/01.wnl.0000262055.45315.f6 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA 170LI UT WOS:000246664500017 PM 17515550 ER PT J AU Hombach, J Cardosa, MJ Sabehareon, A Vaughn, DW Barrett, ADT AF Hombach, Joachim Cardosa, M. Jane Sabehareon, Arunee Vaughn, David W. Barrett, Alan D. T. TI Scientific consultation on immunological correlates of protection induced by dengue vaccines - Report from a meeting held at the World Health Organization 17-18 November 2005 SO VACCINE LA English DT Editorial Material DE dengue; vaccine; immunity; correlates ID ORIGINAL ANTIGENIC SIN; VIRUS-INFECTIONS; DISEASE SEVERITY; ENVELOPE GLYCOPROTEIN; IMMUNE ACTIVATION; HEMORRHAGIC-FEVER; ANTIBODY; IMMUNOGENICITY; RESPONSES; VIREMIA AB Several dengue vaccine candidates have been evaluated in early clinical phase, and some are scheduled for efficacy testing in population-based studies. Given the advancements in dengue vaccine development, there is an increased interest in identifying immunological correlates of protection for these vaccines in order to facilitate their evaluation, further refinement, production and registration. To this end, the WHO Initiative for Vaccine Research (IVR) convened a consultation on primary and secondary immunological correlates of protection induced by dengue vaccines. The meeting was held on the 17th and 18th of November, 2005 at WHO headquarters in Geneva. The consultation was a first dedicated review of the available data in support of establishing correlates. It is concluded that it is not yet possible to define one specific set of correlates, the consultation concluded in recommendations that should help to gather the missing evidence in conjunction with future vaccine trials. C1 WHO, Initiat Vaccine Res, CH-1211 Geneva 27, Switzerland. Univ Malaysia Sarawaki, Inst Hlth & Community Med, Sarawak 94300, Kota Samarahan, Malaysia. Mahidol Univ, Fac Trop Med, Dept Trop Pediat, Bangkok 10700, Thailand. USA, Med Res & Mat Command, Mil Infect Dis Res Program, Ft Detrick, MD 21702 USA. Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA. Univ Texas, Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA. RP Hombach, J (reprint author), WHO, Initiat Vaccine Res, CH-1211 Geneva 27, Switzerland. EM hombachj@who.int RI Cardosa, Mary Jane/A-3611-2009 NR 23 TC 40 Z9 40 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 22 PY 2007 VL 25 IS 21 BP 4130 EP 4139 DI 10.1016/j.vaccine.2007.02.079 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 184KS UT WOS:000247640900003 PM 17428588 ER PT J AU Carra, JH Wannemacher, RW Tammariello, RE Lindsey, CY Dinterman, RE Schokman, RD Smith, LA AF Carra, John H. Wannemacher, Robert W. Tammariello, Ralph E. Lindsey, Changhong Y. Dinterman, Richard E. Schokman, Rowena D. Smith, Leonard A. TI Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity SO VACCINE LA English DT Article DE ricin; adjuvant adsorption; toxin ID ALUMINUM-CONTAINING ADJUVANTS; INFRARED-SPECTROSCOPY; PROTEIN VACCINE; ADSORPTION; IMMUNOGENICITY; ANTIBODIES; MICE; IMMUNOTOXIN; HYDROXIDE; TOXICITY AB Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable, non-toxic and immunogenic recombinant ricin A-chain vaccine (RTA 1-33/44-198) has been developed by protein engineering. We identified optimal formulation conditions for this vaccine under which it remained stable and potent in storage for up to 18 months, and resisted multiple rounds of freeze-thawing without stabilizing co-solvents. Reformulation from phosphate buffer to succinate buffer increased adherence of the protein to aluminum hydroxide adjuvant from 15 to 91%, with a concomitant increase of nearly threefold in effective antigenicity in a mouse model. Using Fourier-transform infrared spectroscopy, we examined the secondary structure of the protein while it was adhered to aluminum hydroxide. Adjuvant adsorption produced only a small apparent change in secondary structure, while significantly stabilizing the protein to thermal denaturation. The vaccine therefore may be safely stored in the presence of adjuvant. Our results suggest that optimization of adherence of a protein antigen to aluminum adjuvant can be a useful route to increasing both stability and effectiveness, and support a role for a "depot effect" of adjuvant. (c) 2007 Published by Elsevier Ltd. C1 USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Ft Detrick, MD 21702 USA. EM Leonard.Smith@AMEDD.army.mil NR 36 TC 36 Z9 37 U1 2 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 22 PY 2007 VL 25 IS 21 BP 4149 EP 4158 DI 10.1016/j.vaccine.2007.03.011 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 184KS UT WOS:000247640900005 PM 17408819 ER PT J AU Webb, RP Smith, TJ Wright, PM Montgomery, VA Meagher, MM Smith, LA AF Webb, Robert P. Smith, Theresa J. Wright, Patrick M. Montgomery, Vicki A. Meagher, Michael M. Smith, Leonard A. TI Protection with recombinant Clostridium botulinum C1 and D binding domain subunit (Hc) vaccines against C and D neurotoxins SO VACCINE LA English DT Article DE botulinum neurotoxin subtypes; recombinant vaccine; receptor-binding domain ID PICHIA-PASTORIS; NUCLEOTIDE-SEQUENCE; AVIAN BOTULISM; SALTON-SEA; D STRAINS; PURIFICATION; TOXIN; CANDIDATE; ANTIGENICITY; ORGANISMS AB Recombinant botulinum Hc (rBoNT He) vaccines for serotypes C1 and D were produced in the yeast Pichia pastoris and used to determine protection against four distinct BoNT C and D toxin subtypes. Mice were vaccinated with rBoNT/C1 He, rBoNT/D He, or with a combination of both vaccines and challenged with BoNT CL D, C/D, or D/C toxin. Mice receiving monovalent vaccinations were partially or completely protected against homologous toxin and not protected against heterologous toxin. Bivalent vaccine candidates completely survived challenges from all toxins except D/C toxin. These results indicate the recombinant C1 and D Hc vaccines are not only effective in a monovalent formula but offer complete protection against both parental and C/D mosaic toxin and partial protection against D/C mosaic toxin when delivered as a bivalent vaccine. (c) 2007 Elsevier Ltd. All rights reserved. C1 USA, Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD 21702 USA. Univ Nebraska, Biol Proc Dev Facil, Dept Chem & Biomol Engn, Lincoln, NE 68588 USA. RP Smith, LA (reprint author), USA, Med Res Inst Infect Dis, Integrated Toxicol Div, 1425 Porter St, Frederick, MD 21702 USA. EM Leonard.smith@amedd.army.mil NR 38 TC 45 Z9 45 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0264-410X J9 VACCINE JI Vaccine PD MAY 22 PY 2007 VL 25 IS 21 BP 4273 EP 4282 DI 10.1016/j.vaccine.2007.02.081 PG 10 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA 184KS UT WOS:000247640900019 PM 17395341 ER PT J AU Upasani, VV Tis, J Bastrom, T Pawelek, J Marks, M Lonner, B Crawford, A Newton, PO AF Upasani, Vidyadhar V. Tis, John Bastrom, Tracey Pawelek, Jeff Marks, Michelle Lonner, Baron Crawford, Alvin Newton, Peter O. TI Analysis of sagittal alignment in thoracic and thoracolumbar curves in adolescent idiopathic scoliosis - How do these two curve types differ? SO SPINE LA English DT Article DE adolescent idiopathic scoliosis; anterior overgrowth; thoracic versus thoracolumbar curves; pelvic and sagittal measurements ID STANDING LATERAL RADIOGRAPHS; ADULT VOLUNTEERS; GROWTH; PELVIS; SPINE; SPONDYLOLISTHESIS; LORDOSIS; BALANCE AB Study Design. Retrospective chart review and radiographic analysis. Objective. To determine if differences exist in the sagittal alignment of adolescent idiopathic scoliosis (AIS) patients with thoracic versus thoracolumbar curve patterns. Summary of Background Data. Relative anterior overgrowth has been suggested as the possible pathomechanism behind thoracic scoliosis. Given the proposed importance of the sagittal alignment on the development of AIS and the known association between pelvic parameters and sagittal alignment, the authors postulate that pelvic incidence may influence the location of vertebral column collapse associated with different AIS curve types. Methods. A multicenter surgical database was used to compare preoperative radiographic measurements between patients with primary thoracic curves (Lenke 1A, B), primary thoracolumbar curves (Lenke 5), and normal adolescents. Results. Pelvic incidence was significantly greater in both groups of AIS patients compared with normal adolescents. Patients in the primary thoracic curve group were found to have a significantly increased sacral slope and a decreased thoracic kyphosis relative to the control group. Patients in the primary thoracolumbar curve group had a significantly increased pelvic tilt; however, a relatively normal thoracic kyphosis, lumbar lordosis, and sacral slope compared with the respective control values. Conclusion. An increased pelvic incidence, associated with both thoracic and thoracolumbar curves when compared with the normal adolescent population, does not appear to be the potential determinant of the development of thoracic versus thoracolumbar scoliosis, but may be a risk factor for the development of adolescent idiopathic scoliosis. The theory of anterior overgrowth may be supported by the identification of thoracic hypokyphosis, despite an increased pelvic incidence and lumbar lordosis, in patients with thoracic scoliosis. The association between sagittal measurements and the etiology of thoracolumbar curve formation is less clear; however, regional anterior overgrowth in the lumbar spine may also be responsible for the deformity. C1 Univ Calif San Diego, Dept Orthopaed Surg, San Diego, CA 92103 USA. Rady Childrens Hosp, Dept Orthopaed, San Diego, CA USA. Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Scoliosis Associates, New York, NY USA. Childrens Hosp, Dept Orthopaed, Cincinnati, OH 45229 USA. RP Newton, PO (reprint author), 3030 Childrens Way,Suite 410, San Diego, CA 92123 USA. EM pnewton@chsd.org NR 18 TC 46 Z9 63 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0362-2436 J9 SPINE JI SPINE PD MAY 20 PY 2007 VL 32 IS 12 BP 1355 EP 1359 DI 10.1097/BRS.0b013e318059321d PG 5 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA 171JH UT WOS:000246731600015 PM 17515826 ER PT J AU Chen, RW Williams, AJ Liao, ZL Yao, CP Tortella, FC Dave, JR AF Chen, Ren-Wu Williams, Anthony J. Liao, Zhilin Yao, Changping Tortella, Frank C. Dave, Jitendra R. TI Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation SO NEUROSCIENCE LETTERS LA English DT Article DE phosphodiesterase inhibitors; neuroprotection; caspase-3; cell-cycle elements ID SPINAL MOTOR-NEURONS; GENE-EXPRESSION; IN-VITRO; FUNCTIONAL RECOVERY; AXON REGENERATION; APOPTOSIS; DEATH; PROLIFERATION; PROTEIN; KINASE AB Cellular injury can involve the aberrant stimulation of cell cycle proteins in part through activation of phosphodiesterases (PDEs) and downstream expression of cell-cycle components such as cyclin DI. In mature non-proliferating cells activation of the cell cycle can lead to the induction of programmed cell death. In the present study, we investigated the in vitro neuroprotective efficacy and mechanism of action of vinpocetine (PDE1 inhibitor), trequinsin (PDE3 inhibitor), and rolipram (PDE4 inhibitor) in four mechanistically-distinct models of injury to primary rat cortical neurons as related to cell cycle regulation and apoptosis. Cellular injury was induced by hypoxia/hypoglycemia, veratridine (10 [LM), staurosporine (I LM), or glutamate (100 mu M), resulting in average neuronal cell death rates of 43-48% as determined by MTT assay. Treatment with each PDE inhibitor (PDEI) resulted in a similar concentration-dependent neuroprotection profile with maximal effective concentrations of 5-10 mu M (55-77% neuroprotection) in all four neurotoxicity models. Direct cytotoxicity due to PDE inhibition alone was not observed at concentrations below 100 mu M. Further studies indicated that PDEIs can suppress the excitotoxic upregulation of cyclin D 1 similar to the effects of flavopiridol, a cyclin-dependent kinase inhibitor, including suppression of pro-apoptotic capase-3 activity. Overall, these data indicate that PDEIs are broad-spectrum neuroprotective agents acting through modulation of cell cycle elements and may offer a novel mode of therapy against acute injury to the brain. Published by Elsevier Ireland Ltd. C1 Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. RP Dave, JR (reprint author), Walter Reed Army Inst Res, Div Psychiat & Neurosci, Dept Appl Neurobiol, Silver Spring, MD 20910 USA. EM jit.dave@na.amedd.army.mil RI Yao, Changping/B-3619-2011 NR 38 TC 33 Z9 34 U1 0 U2 1 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0304-3940 J9 NEUROSCI LETT JI Neurosci. Lett. PD MAY 17 PY 2007 VL 418 IS 2 BP 165 EP 169 DI 10.1016/j.neulet.2007.03.033 PG 5 WC Neurosciences SC Neurosciences & Neurology GA 173KJ UT WOS:000246871600010 PM 17398001 ER PT J AU Nesti, LJ Caterson, EJ Li, WJ Chang, R McCann, TD Hoek, JB Tuan, RS AF Nesti, Leon J. Caterson, E. J. Li, Wan-Ju Chang, Richard McCann, Thane D. Hoek, Jan B. Tuan, Rocky S. TI TGF-beta 1 calcium signaling in osteoblasts SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Article DE TGF-beta 1; Ca2+ signaling; osteoblast; cell adhesion; Ca2+ channel; Smad; Fura-2 ID GROWTH-FACTOR-BETA; TGF-BETA; CELL-ADHESION; MATRIX MINERALIZATION; INTEGRIN EXPRESSION; OSTEOSARCOMA CELLS; SMAD PROTEINS; RAT BONE; IN-VITRO; IGF-I AB Transforming growth factor-beta 1 (TGF-beta 1) action is known to be initiated by its binding to multiple cell surface receptors containing serine/threonine kinase domains that act to stimulate a cascade of signaling events in a variety of cell types. We have previously shown that TGF-beta 1 and BMP-2 treatment of primary human osteoblasts (HOBs) enhances cell-substrate adhesion. In this report, we demonstrate that TGF-beta 1 elicits a rapid, transient, and oscillatory rise in the intracellular Ca2+ concentration, [Ca2+](i), that is necessary for enhancement of cell adhesion in HOBs but does not alter the phosphorylation state of Smad proteins. This rise in [Ca2+](i) in HOB is not observed in the absence of extracellular calcium or when the cells are treated with the L-type Ca2+ channel blocker, nifeclipine, but is stimulated upon treatment with the L-type Ca2+ channel agonist, Bay K 8644, or under high K+ conditions. The rise in [Ca2+](i) is severely attenuated after treatment of the cells with thapsigargin, a selective encloplasmic reticulum Ca2+ PUMP inhibitor. TGF-beta 1 enhancement of HOB adhesion to tissue culture polystyrene is also inhibited in cells treated with nifeclipine. These data suggest that intracellular Ca2+ signaling is an important second messenger of the TGF-beta 1 signal transcluction pathway in osteoblast function. C1 NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA. Walter Reed Army Med Ctr, Dept Orthopaed & Rehabil, Washington, DC 20307 USA. Harvard Univ, Sch Med, Dept Plast & Reconstruct Surg, Boston, MA 02114 USA. Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA. Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA. RP Tuan, RS (reprint author), NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bldg 50,Room 1523,50 S Dr,MSC 8022, Bethesda, MD 20892 USA. EM tuanr@mail.nih.gov RI Li, Wan-Ju/A-7002-2008 FU Intramural NIH HHS; NIAAA NIH HHS [AA07186, AA07215, F30 AA05516, AA08714]; NIAMS NIH HHS [AR Z01 41113, AR44501]; NIDCR NIH HHS [DE11327, DE16864] NR 60 TC 24 Z9 24 U1 1 U2 7 PU WILEY-LISS PI HOBOKEN PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAY 15 PY 2007 VL 101 IS 2 BP 348 EP 359 DI 10.1002/jcb.21180 PG 12 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 162XP UT WOS:000246123100007 PM 17211850 ER PT J AU Zhong, J Chen, H Saraf, G Lu, Y Choi, CK Song, JJ Mackie, DM Shen, H AF Zhong, J. Chen, H. Saraf, G. Lu, Y. Choi, C. K. Song, J. J. Mackie, D. M. Shen, H. TI Integrated ZnO nanotips on GaN light emitting diodes for enhanced emission efficiency SO APPLIED PHYSICS LETTERS LA English DT Article ID EXTRACTION; NANORODS; GROWTH AB Enhancement of light extraction from an integrated ZnO nanotips/GaN light emitting diode (LED) is demonstrated. The device is composed of a GaN LED with a Ga-doped ZnO (GZO) transparent conductive layer and ZnO nanotips grown on GZO for light extraction. The light output power of a ZnO nanotips/GZO/GaN LED exhibits 1.7 times enhancement, in comparison with a conventional Ni/Au p-metal LED. The higher emission efficiency is attributed to the enhanced light transmission and scattering in the ZnO/GaN multilayer. (C) 2007 American Institute of Physics. C1 Rutgers State Univ, Dept Elect & Comp Engn, Piscataway, NJ 08854 USA. ZN Technol, Brea, CA 92821 USA. Univ Calif San Diego, La Jolla, CA 92093 USA. USA, Res Lab, Adelphi, MD 20783 USA. RP Zhong, J (reprint author), Rutgers State Univ, Dept Elect & Comp Engn, Piscataway, NJ 08854 USA. EM ylu@ece.rutgers.edu NR 16 TC 106 Z9 111 U1 3 U2 41 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 14 PY 2007 VL 90 IS 20 AR 203515 DI 10.1063/1.2741052 PG 3 WC Physics, Applied SC Physics GA 169WT UT WOS:000246623500097 ER PT J AU Tovanabutra, S de Souza, M Sittisombut, N Sriplienchan, S Ketsararat, V Birx, DL Khamboonrueng, C Nelson, KE McCutchan, FE Robb, ML AF Tovanabutra, Sodsai de Souza, Mark Sittisombut, Nopporn Sriplienchan, Somchai Ketsararat, Vidhaya Birx, Deborah L. Khamboonrueng, Chirasak Nelson, Kenrad E. McCutchan, Francine E. Robb, Merlin L. TI HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE SO AIDS LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; TO-CHILD TRANSMISSION; PERINATAL TRANSMISSION; GENITAL SECRETIONS; VARIANTS; POPULATIONS; DISTINCT; INFANTS; MOTHERS; BLOOD AB Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses. C1 Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. Chiang Mai Univ, Fac Med, Chiang Mai 50000, Thailand. US Mil HIV Res Program, Henry M Jackson Fdn, Rockville, MD USA. Armed Forces Res Inst Med Sci, US Component, Bangkok 10400, Thailand. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. Royal Thai Army, Phramongkutklao Hosp, Bangkok, Thailand. Lampang Hosp, Lampang, Thailand. USMHRP, Walter Reed Army Inst Res, Rockville, MD USA. Ctr Dis Control, Atlanta, GA 30333 USA. RP Tovanabutra, S (reprint author), Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand. FU NICHD NIH HHS [R01 HD34343-03] NR 15 TC 9 Z9 9 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0269-9370 J9 AIDS JI Aids PD MAY 11 PY 2007 VL 21 IS 8 BP 1050 EP 1053 DI 10.1097/QAD.0b013e32810c8cf3 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA 171RW UT WOS:000246754100022 PM 17457103 ER PT J AU Gupta, N Suhre, DR AF Gupta, Neelam Suhre, Dennis R. TI Acousto-optic tunable filter imaging spectrometer with full Stokes polarimetric capability SO APPLIED OPTICS LA English DT Article ID ELLIPSOMETER; SURFACES AB Polarization is an important addition to spectral imaging in detecting and identifying objects of interest, and simple linear polarization measurements are often inadequate. Full polarization analysis can give additional information for discrimination where the polarization state is completely described by the Stokes parameters. An acousto-optic tunable filter (AOTF) imaging system was built incorporating two liquid-crystal variable retarders (LCVRs) that can provide complete spectral-polarimetric analysis, and it is believed to be the first demonstration of a full Stokes polarimetric AOTF spectral imaging system with no moving parts. It is also shown that a single LCVR cannot provide all the Stokes parameters. (c) 2007 Optical Society of America. C1 USA, Res Lab, Adelphi, MD 20783 USA. DRS Sci Inc, New Kensington, PA 15068 USA. RP Gupta, N (reprint author), USA, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA. EM ngupta@arl.army.mil RI Gupta, Neelam/B-8702-2013 NR 25 TC 19 Z9 21 U1 1 U2 8 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD MAY 10 PY 2007 VL 46 IS 14 BP 2632 EP 2637 DI 10.1364/AO.46.002632 PG 6 WC Optics SC Optics GA 164MK UT WOS:000246237900009 PM 17446911 ER PT J AU He, HY Pandey, R Karna, SP AF He, Haiying Pandey, Ravindra Karna, Shashi P. TI Electronic structure mechanism of spin-polarized electron transport in a Ni-C-60-Ni system SO CHEMICAL PHYSICS LETTERS LA English DT Article ID CONDUCTANCE; DENSITY; MOLECULES; PROBES AB The nature of chemical bonding and its effect on spin-polarized electron transport in Ni-C-60-Ni are studied using density functional theory in conjunction with the Landauer-Buttiker formalism. The binding site on the C-60 cage surface appears to have a strong influence on the electron tunneling current between Ni leads. The tunnel current has a much higher magnitude when Ni is bonded to hole sites (H6, H5) than at bridge sites (B66, B56) of the fullerene cage. Furthermore, the magnitude of junction magnetoresistance is predicted to be significantly high for the molecular Ni-C-60-Ni system. (c) 2007 Elsevier B.V. All rights reserved. C1 USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. Michigan Technol Univ, Dept Phys, Houghton, MI 49931 USA. Michigan Technol Univ, Multiscale Technol Inst, Houghton, MI 49931 USA. RP Pandey, R (reprint author), USA, Res Lab, Weap & Mat Res Directorate, ATTN AMSRD ARL WM, Aberdeen Proving Ground, MD 21005 USA. EM pandey@mtu.edu; skarna@arl.army.mil RI Pandey, Ravi/A-8759-2009 NR 19 TC 14 Z9 14 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD MAY 4 PY 2007 VL 439 IS 1-3 BP 110 EP 114 DI 10.1016/j.cplett.2007.03.060 PG 5 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 169RQ UT WOS:000246609800023 ER PT J AU Orlicki, JA Kosik, WE Demaree, JD Bratcher, MS Jensen, RE McKnight, SH AF Orlicki, Joshua A. Kosik, Wendy E. Demaree, J. Derek Bratcher, Matthew S. Jensen, Robert E. McKnight, Steven H. TI Surface segregation of branched polyethyleneimines in a thermoplastic polyurethane SO POLYMER LA English DT Article DE hyperbranched polymer; surface segregation; polyoxometalate ID POLYMER BLENDS; HYPERBRANCHED POLYMERS; AEROBIC OXIDATION; PROCESSING AID; END-GROUPS; DENDRIMERS; THERMODYNAMICS; NANOCARRIERS; FILMS AB Hyperbranched polyethyleneimines were modified with methacrylated fluorosurfactants and aliphatic epoxides to provide a library of macromolecules with controlled chain ends and residual amine functionality. These materials were co-dissolved with a thermoplastic polyurethane-ether and the blends were subsequently deposited as films cast from solution. The surface chemistry of the cast films was determined using angle resolved X-ray photoelectron spectroscopy (AR-XPS) and Rutherford backscattering spectroscopy (RBS). Experimental results indicate that the modified hyperbranched polymers (HBPs) concentrate at the air-polymer interface. Furthermore, HBPs that were complexed to polyoxometalates (POMs) using electrostatic interactions also exhibited surface segregation in cast polymer films, resulting in ca. 10-fold increase of metal at the film surface relative to the known bulk concentration. Results from XPS and RBS examination of the films are consistent with surface segregation of the HBP-POM hybrids, exhibiting increased metal, fluorine, and nitrogen content near the surface of the film, as well as significant changes in wetting behavior. This study indicates that modified HBPs may be used to selectively transport inorganic species such as polyoxometalates to polymer film surfaces. (c) 2007 Published by Elsevier Ltd. C1 AMSRD ARL WM MA, Rodman Mat Res Ctr, Multifunct Mat Branch, Army Res Lab, Aberdeen Proving Ground, MD 21005 USA. RP McKnight, SH (reprint author), AMSRD ARL WM MA, Rodman Mat Res Ctr, Multifunct Mat Branch, Army Res Lab, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA. EM shm@arl.army.mil NR 33 TC 8 Z9 8 U1 3 U2 10 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0032-3861 J9 POLYMER JI Polymer PD MAY 4 PY 2007 VL 48 IS 10 BP 2818 EP 2826 DI 10.1016/jpolymer.2007.03.021 PG 9 WC Polymer Science SC Polymer Science GA 169CE UT WOS:000246569500003 ER PT J AU Burnett, JC Opsenica, D Sriraghavan, K Panchal, RG Ruthel, G Hermone, AR Nguyen, TL Kenny, TA Lane, DJ McGrath, CF Schmidt, JJ Vennerstrom, JL Gussio, R Solaja, BA Bavari, S AF Burnett, James C. Opsenica, Dejan Sriraghavan, Kamaraj Panchal, Rekha G. Ruthel, Gordon Hermone, Ann R. Nguyen, Tam L. Kenny, Tara A. Lane, Douglas J. McGrath, Connor F. Schmidt, James J. Vennerstrom, Jonathan L. Gussio, Rick Solaja, Bogdan A. Bavari, Sina TI A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype a metalloprotease SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SMALL-MOLECULE INHIBITORS; TOXIN TYPE-A; CLOSTRIDIUM-BOTULINUM; ZINC ENDOPEPTIDASE; NEUROTRANSMITTER RELEASE; ANTIMALARIAL ACTIVITY; CRYSTAL-STRUCTURE; PROTEASE ACTIVITY; MEDICAL ASPECTS; BINDING AB We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including antimalarial drugs) contained a 4-amino-7-chloroquinoline (ACQ) substructure and a separate positive ionizable amine component. The same antimalarials have also been found to interfere with BoNT/A translocation into neurons, via pH elevation of the toxin-mediated endosome. Thus, this structural class of small molecules may serve as dual-function BoNT/A inhibitors. In this study, we used a refined pharmacophore for BoNT/A LC inhibition to identify four new, potent inhibitors of this structural class (IC(50)'s ranged from 3.2 to 17 mu M). Molecular docking indicated that the binding modes for the new SMNPIs are consistent with those of other inhibitors that we have identified, further supporting our structure-based pharmacophore. Finally, structural motifs of the new SMNPIs, as well as two structure-based derivatives, were examined for activity, providing valuable information about pharmacophore component contributions to inhibition. C1 Univ Belgrade, Fac Chem, Belgrade 11001, Serbia. SAIC Frederick Inc, Target Struct Based Discovery Grp, Natl Canc Inst, Frederick, MD 21702 USA. Inst Chem Technol & Met, Belgrade 11001, Serbia. Univ Nebraska, Med Ctr, Coll Pharm, Omaha, NE 68198 USA. USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA. NCI Frederick, Dev Therapeut Program, Ft Detrick, MD 21702 USA. RP Solaja, BA (reprint author), Univ Belgrade, Fac Chem, Studentski Trg 16,POB 158, Belgrade 11001, Serbia. EM bsolaja@chem.bg.ac.yu; sina.bavari@us.army.mil OI Solaja, Bogdan/0000-0002-9975-2725 FU NCI NIH HHS [N01-CO-12400] NR 60 TC 40 Z9 40 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAY 3 PY 2007 VL 50 IS 9 BP 2127 EP 2136 DI 10.1021/jm061446e PG 10 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA 160PK UT WOS:000245954600015 PM 17417831 ER PT J AU Zhang, HT Ye, JC Joshi, SP Schoenung, JM Chin, ESC Gazonas, GA Ramesh, KT AF Zhang, Haitao Ye, Jichun Joshi, Shailendra P. Schoenung, Julie M. Chin, Ernest S. C. Gazonas, George A. Ramesh, Kaliat T. TI Superlightweight nanoengineered aluminum for strength under impact SO ADVANCED ENGINEERING MATERIALS LA English DT Article ID REINFORCED AL NANOCOMPOSITE; STRAIN GRADIENT PLASTICITY; GRAIN-SIZE; MG ALLOY; FABRICATION; DUCTILITY C1 Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. USA, Ballist Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Zhang, HT (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA. EM jmschoenung@ucdavis.edu; ramesh@jhu.edu RI Joshi, Shailendra/A-2714-2008; OI Joshi, Shailendra/0000-0002-2141-2851; Gazonas, George/0000-0002-2715-016X NR 23 TC 12 Z9 12 U1 0 U2 8 PU WILEY-V C H VERLAG GMBH PI WEINHEIM PA POSTFACH 101161, 69451 WEINHEIM, GERMANY SN 1438-1656 EI 1527-2648 J9 ADV ENG MATER JI Adv. Eng. Mater. PD MAY PY 2007 VL 9 IS 5 BP 355 EP 359 DI 10.1002/adem.200700015 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 177PH UT WOS:000247164500004 ER PT J AU Oh, RC Lanier, JB AF Oh, Robert C. Lanier, J. Brian TI Management of hypertriglyceridemia SO AMERICAN FAMILY PHYSICIAN LA English DT Article ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; POLYUNSATURATED FATTY-ACIDS; ARTERY-DISEASE; COMBINED HYPERLIPIDEMIA; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SECONDARY PREVENTION; METABOLIC SYNDROME; FISH-OIL AB Hypertriglyceridemia is associated with an increased risk of cardiovascular events and acute pancreatitis. Along with lowering low-density lipoprotein cholesterol levels and raising high-density lipoprotein cholesterol levels, lowering triglyceride levels in high-risk patients (e.g., those with cardiovascular disease or diabetes) has been associated with decreased cardiovascular morbidity and mortality. Although the management of mixed dyslipidemia is controversial, treatment should focus primarily on lowering low-density lipoprotein cholesterol levels. Secondary goals should include lowering non-high-density lipoprotein cholesterol levels (calculated by subtracting high-density lipoprotein cholesterol from total cholesterol). If serum triglyceride levels are high, lowering these levels can be effective at reaching non-high-density lipoprotein cholesterol goals. Initially, patients with hypertriglyceridemia should be counseled about therapeutic lifestyle changes (e.g., healthy diet, regular exercise, tobacco-use cessation). Patients also should be screened for metabolic syndrome and other acquired or secondary causes. Patients with borderline-high serum triglyceride levels (i.e., 150 to 199 mg per dL [ 1.70 to 2.25 mmol per L]) and high serum triglyceride levels (i.e., 200 to 499 mg per dL [2.26 to 5.64 mmol per L]) require an overall cardiac risk assessment. Treatment of very high triglyceride levels (i.e., 500 mg per dL [5.65 mmol per L] or higher) is aimed at reducing the risk of acute pancreatitis. Statins, fibrates, niacin, and fish oil (alone or in various combinations) are effective when pharmacotherapy is indicated. C1 Tripler Army Med Ctr, Family Med Residency Program, Honolulu, HI 96859 USA. Martin Army Community Hosp, Ft Benning, GA USA. RP Oh, RC (reprint author), Tripler Army Med Ctr, Family Med Residency Program, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM roboh98@gmail.com NR 40 TC 32 Z9 37 U1 0 U2 2 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAY 1 PY 2007 VL 75 IS 9 BP 1365 EP 1371 PG 7 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA 164NK UT WOS:000246240600012 PM 17508532 ER PT J AU Aberle, C AF Aberle, Curtis TI Field expediency and operation Iraqi freedom SO AMERICAN JOURNAL OF NURSING LA English DT Editorial Material C1 Brooke Army Med Ctr, USA, Staff Family NP, Ft Sam Houston, TX 78234 USA. RP Aberle, C (reprint author), Brooke Army Med Ctr, USA, Staff Family NP, Ft Sam Houston, TX 78234 USA. EM curtis.oberle@us.army.mil NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0002-936X J9 AM J NURS JI Am. J. Nurs. PD MAY PY 2007 VL 107 IS 5 BP 58 EP 58 PG 1 WC Nursing SC Nursing GA 166NC UT WOS:000246384700029 ER PT J AU Morales, KJ Gordon, MC Bates, GW AF Morales, Kelly J. Gordon, Michael C. Bates, G. Wright, Jr. TI Postcesarean delivery adhesions associated with delayed delivery of infant SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT Armed Forces District Meeting of the American-College-of-Obstetricians-and-Gynecologists CY OCT 30-NOV 03, 2005 CL Seattle, WA SP Amer Coll Obstetricians & Gynecologists, Armed Forces District DE adhesion; cesarean delivery; complication; pregnancy ID CESAREAN-SECTION; MODE; TERM; RISK AB OBJECTIVE: The purpose of this study was to estimate the incidence of adhesions after cesarean deliveries and to determine their impact on delivery and infant well-being. STUDY DESIGN: This was a retrospective cohort analysis with chart review. The charts of 542 women who had undergone primary ( 265 women) or repeat cesarean ( 277 women) deliveries were reviewed. The incidence, severity, and locations of adhesions; delivery time; cord blood pH, and Apgar scores were noted. RESULTS: After the first cesarean delivery, 100 of 217 women (46%) had pelvic adhesive disease; 48 of 64 women (75%) who underwent a third cesarean delivery and 5 of 6 women (83%) who underwent fourth cesarean delivery had formed pelvic adhesive disease. Compared with primary cesarean section, delivery of the infant was delayed 5.6 minutes (52%) with 1 previous cesarean birth, 8.5 minutes (79%) after 2 cesarean birth, and 18.1 (169%) during the fourth cesarean birth ( P < 0.001 for all comparisons). CONCLUSION: A high percentage of cesarean deliveries result in adhesive disease, which delays repeat cesarean delivery of the fetus. The potential for adhesive disease should be included in counseling regarding primary elective cesarean births. C1 Wilford Hall USAF Med Ctr, San Antonio Uniformed Serv Hlth Educ Consortium, San Antonio, TX USA. Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. RP Bates, GW (reprint author), Atlanta Ctr Reprod Med, 100 Stone Forest Dr,Suite 300, Woodstock, GA 30189 USA. EM wright.bates@acrm.com NR 16 TC 7 Z9 8 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD MAY PY 2007 VL 196 IS 5 AR 461.e1 DI 10.1016/j.ajog.2006.12.017 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA 165ZK UT WOS:000246346200013 PM 17466702 ER PT J AU Provenzale, JM Liang, LL York, GE DeLong, DM White, LE AF Provenzale, J. M. Liang, L. L. York, G. E. DeLong, D. M. White, L. E. TI Analysis of Signal Intensity Changes Representing Brain Maturation During the First Postnatal Year SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract C1 [York, G. E.] Brooke Army Med Ctr, San Antonio, TX USA. [Provenzale, J. M.; DeLong, D. M.; White, L. E.] Duke Univ, Med Ctr, Durham, NC USA. EM prove001@mc.duke.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2007 VL 188 IS 5 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA V04XA UT WOS:000207089900245 ER PT J AU Provenzale, JM Golding, LD Choma, M York, G AF Provenzale, J. M. Golding, L. D. Choma, M. York, G. TI Values from Dynamic Contrast-enhanced Imaging and Cerebral Blood Volume Imaging Correlate in Patients with High-grade Glial Neoplasms SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract C1 [Choma, M.] Boston Childrens Hosp, Boston, MA USA. [York, G.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. [Provenzale, J. M.] Duke Univ, Med Ctr, Durham, NC USA. [Golding, L. D.] Moses Cone Hosp, Greensboro, NC USA. EM prove001@mc.duke.edu NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2007 VL 188 IS 5 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA V04XA UT WOS:000207089900145 ER PT J AU Walden, MJ Murphey, MD AF Walden, M. J. Murphey, M. D. TI Incidental Enchondromas of the Knee SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Meeting Abstract C1 [Murphey, M. D.] Armed Forces Inst Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. [Walden, M. J.] Walter Reed Army Med Ctr, Washington, DC 20307 USA. EM mandj02@comcast.net NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 USA SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 2007 VL 188 IS 5 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA V04XA UT WOS:000207089900281 ER PT J AU Lentine, K Schmitz, L Wasi, N Buchanan, P Schnitzler, M Abbott, K Salvalaggio, P Brennan, D AF Lentine, Krista Schmitz, Leslie Wasi, Nadia Buchanan, Paula Schnitzler, Mark Abbott, Kevin Salvalaggio, Paolo Brennan, Daniel TI The relationship of body mass index to post-transplant cardiac risk varies with baseline comorbidity status. SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT Annual American Transplant Congress CY MAY 05-09, 2007 CL San Francisco, CA C1 St Louis Univ, Ctr Outcomes Res, St Louis, MO 63103 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Washington Univ, St Louis, MO 63130 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAY PY 2007 VL 7 SU 2 MA 553 BP 291 EP 292 PG 2 WC Surgery; Transplantation SC Surgery; Transplantation GA 166HQ UT WOS:000246370200553 ER PT J AU Ortiz, JA Palma-Vargas, 'M Wright, FH Membreno, FE Harrison, S Foster, PF AF Ortiz, Jorge A. Palma-Vargas, Juan M. Wright, Francis H. Membreno, Fernando E. Harrison, Stephen Foster, Preston F. TI Hepatitis c and end stage renal disease: A global survey. SO AMERICAN JOURNAL OF TRANSPLANTATION LA English DT Meeting Abstract CT Annual American Transplant Congress CY MAY 05-09, 2007 CL San Francisco, CA C1 Methodist Specialty & Transplant Hosp, San Antonio, TX USA. Brooke Army Med Ctr, San Antonio, TX USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1600-6135 J9 AM J TRANSPLANT JI Am. J. Transplant. PD MAY PY 2007 VL 7 SU 2 MA 836 BP 363 EP 363 PG 1 WC Surgery; Transplantation SC Surgery; Transplantation GA 166HQ UT WOS:000246370201272 ER PT J AU Wortmann, G Hochberg, LP Arana, BA Rizzo, NR Arana, F Ryan, JR AF Wortmann, Glenn Hochberg, Lisa P. Arana, Byron A. Rizzo, Nidia R. Arana, Flora Ryan, Jeffrey R. TI Diagnosis of cutaneous leishmaniasis in Guatemala using a real-time polymerase chain reaction assay and the smartcycler (R) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IDENTIFICATION AB The polymerase chain reaction (PCR) assay has been reported for the diagnosis of cutaneous leishmaniasis (CL). Real-time (RT) PCR offers several advantages over traditional PCR, including faster processing time and decreased risk of contamination. Enhanced portability is another benefit that expands the applicability of the assay. A portable RT-PCR assay was transported from the United States to Guatemala for comparison with traditional diagnostic modalities. With the clinical diagnosis of CL as the gold standard, RT-PCR was positive in 86% (37 of 43) versus 53% (20 of 38) for microscopy and 72% (28 of 39) for culture. Negative RT-PCR samples (6) were also negative by traditional diagnostic methods (although subsequently determined to be positive by a nested kDNA PCR). Sixty-four percent (9 of 14) of cases tested and negative by microscopy and/or culture were positive by RT-PCR. This study demonstrates that a RT-PCR assay can be successfully deployed to offer enhanced sensitivity for the diagnosis of CL. C1 Walter Reed Army Med Ctr, ID Clin, Div Infect Dis, Washington, DC 20307 USA. Walter Reed Army Inst Res, Dept Enteroviruses, Div Communicable Dis & Immunol, Silver Spring, MD USA. Univ Valle Guatemala, Med Entomol Res & Training Unit, Guatemala City, Guatemala. Jacksonville State Univ, Dept Emergency Management, Jacksonville, AL 36265 USA. RP Wortmann, G (reprint author), Walter Reed Army Med Ctr, ID Clin, Div Infect Dis, Ward 63,6900 Georgia Ave, Washington, DC 20307 USA. EM Glenn.Wortmann@na.amedd.army.mil NR 9 TC 10 Z9 10 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 2007 VL 76 IS 5 BP 906 EP 908 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA 165SR UT WOS:000246326300024 PM 17488914 ER PT J AU Scranton, SE Waibel, KH AF Scranton, Stephen E. Waibel, Kirk H. TI Interpretation of pneumococcal vaccine response SO ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY LA English DT Letter ID POLYSACCHARIDE C1 Wilford Hall USAF Med Ctr, Dept Allergy & Immunol, Lackland AFB, TX 78236 USA. Brooke Army Med Ctr, Allergy Immunol Clin, Ft Sam Houston, TX 78234 USA. RP Scranton, SE (reprint author), Wilford Hall USAF Med Ctr, Dept Allergy & Immunol, Lackland AFB, TX 78236 USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 USA SN 1081-1206 J9 ANN ALLERG ASTHMA IM JI Ann. Allergy Asthma Immunol. PD MAY PY 2007 VL 98 IS 5 BP 499 EP 500 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA 170GQ UT WOS:000246651200016 PM 17521039 ER PT J AU Shriver, CD AF Shriver, Craig D. TI How does it feel? Sentinel node biopsy is better SO ANNALS OF SURGICAL ONCOLOGY LA English DT Editorial Material ID BREAST-CANCER C1 Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. RP Shriver, CD (reprint author), Walter Reed Army Med Ctr, Dept Surg, Washington, DC 20307 USA. EM craig.shriver@na.amedd.army.mil NR 4 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1068-9265 J9 ANN SURG ONCOL JI Ann. Surg. Oncol. PD MAY PY 2007 VL 14 IS 5 BP 1530 EP 1531 DI 10.1245/s10434-007-9352-5 PG 2 WC Oncology; Surgery SC Oncology; Surgery GA 169KN UT WOS:000246591200005 PM 17404797 ER PT J AU Bliese, PD McGurk, D Thomas, JL Balkin, TJ Wesensten, N AF Bliese, Paul D. McGurk, Dennis Thomas, Jeffrey L. Balkin, Thomas J. Wesensten, Nancy TI Discontinuous growth modeling of adaptation to sleep setting changes: Individual differences and age SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE multilevel models; sleep; individual differences; age; discontinuous growth models; transitions ID RESTRICTION AB Introduction: Biomedical devices allow investigators to collect longterm repeated measures data to study adaptation. We examined 26 d of actigraph sleep data and tested for individual differences in sleep patterns prior to, during, and after a transition of sleeping in garrison to sleeping in a field exercise setting. In addition, we examined whether the individual difference variable of participant age (a continuous variable ranging from 19-29 yr) was related to sleep patterns. Methods: Actigraph data was obtained from 77 cadets participating in a month-long military training program. At day 17, participants transitioned from sleeping in garrison to sleeping in a field exercise setting. A discontinuous growth model tested for individual differences in 1) overall sleep time, 2) garrison sleep slope, 3) the transition, and 4) the sleep slope during the field exercise setting. Results: Individuals varied significantly in their overall sleep time, pattern of sleep in garrison, and the degree to which sleep decreased at the transition. The decline in sleep at the transition was related to participant age such that increases in age were associated with larger declines in sleep minutes. Discussion: Individuals display significant variability in sleep patterns that can be detected using discontinuous growth models. The individual difference variable of participant age explains some of this variability. Much of the variability, however, remains unexplained. Future work will benefit from using discontinuous growth models to identify and model individual difference variables such as age when examining response patterns and transitions in data collected in applied field settings. C1 USA, Med Res Unit Europe, Heidelberg, Germany. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Bliese, PD (reprint author), USA, Res Unit Europe, CMR 442,Box 305, APO, AE 09042 USA. EM paul.bliese@us.army.mil NR 20 TC 6 Z9 6 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 BP 485 EP 492 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 165ZT UT WOS:000246347100005 PM 17539442 ER PT J AU Cosenzo, KA Fatkin, LT Patton, DJ AF Cosenzo, Keryl A. Fatkin, Linda T. Patton, Debra J. TI Ready or not: Enhancing operational effectiveness through use of readiness measures SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE assessment; cognition; cognitive readiness; performance; stress; decision making; salivary amylase; personality ID SELF-EFFICACY; RECONCEPTUALIZING AROUSAL; INDIVIDUAL-DIFFERENCES; PERFORMANCE; PERSONALITY; ABILITY; STRESS; NEED; CONSTRUCTION; VALIDATION AB Current and future military operations require personnel to perform a multitude of mission tasks. Military personnel are required to execute these tasks, and to perform to high levels of expectation. Many of these tasks are complex and demand substantial cognitive readiness, which may optimize and enhance cognitive performance. Technologies are being developed to aid individual soldiers to successfully complete their missions; however, the proliferation of new technologies, coupled with the varying operational missions, make leveraging cognitive readiness a mandate for the achievement of military effectiveness and enhanced overall performance. It is important to have a militarily relevant psychological battery that can be used to assess each individual's cognitive capabilities and appraisals, factors that enhance military operational effectiveness. Assessing individual cognitive readiness becomes particularly important when researchers broaden their examinations of military effectiveness to assess team cognition, team behavior, and team effectiveness. We discuss the theoretical development and the components of the U.S. Army Research Laboratory's Readiness Assessment and Monitoring System (RAMS). Data from several studies are presented to illustrate the behavioral profiles of individuals in extreme operational environments. Data show how specific factors (e.g., personality, coping) contribute to performance in operational settings (e.g., command and control, chemical decontamination operations). Understanding the effect of cognitive readiness on overall military effectiveness not only has implications for selection, training, and system design, but also provides the basis for the proactive development and sustainment of optimal performance, both in individual soldiers, and in small teams or military units. C1 USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA. RP Cosenzo, KA (reprint author), USA, Res Lab, Human Res & Engn Directorate, Bldg 459, Aberdeen Proving Ground, MD 21005 USA. EM kcosenzo@arl.army.mil NR 59 TC 5 Z9 6 U1 1 U2 5 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B96 EP B106 PG 11 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800014 PM 17547310 ER PT J AU Kautz, MA Thomas, ML Caldwell, JL AF Kautz, Mary A. Thomas, Maria L. Caldwell, J. Lynn TI Considerations of pharmacology on fitness for duty in the operational environment SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material DE fatigue countermeasures; pharmacology countermeasures; cognitive performance; psychotropic; military operations; pharmaceuticals ID HELICOPTER PILOT PERFORMANCE; SLEEP-DEPRIVATION; FATIGUE COUNTERMEASURES; US MILITARY; ETHICAL USE; COGNITIVE PERFORMANCE; EXECUTIVE FUNCTION; CAFFEINE; MODAFINIL; ALERTNESS AB Coordination of strategies for transitioning psychoactive pharmacological compounds from basic laboratory research to the field environment has been an ongoing effort among military laboratories. Several workshops have been held specifically to address the operationally relevant issues and other military and scientific challenges as they relate to the enhancement and sustainability of cognitive performance. in this preface, we tie together recommendations of the Pharmacological Strategies Focus Team for one such Workshop, review current literature, and discuss findings reported at recent professional meetings. The papers presented within this pharmacology section are discussed. These section papers are organized into three areas of operational relevance-the first assesses the effectiveness of a treatment given for migraines, a condition with known detrimental effects on productivity and readiness; the second discusses ethical considerations surrounding the use of pharmaceutical countermeasures for fatigue in the operational environment; and the third discusses a case report highlighting the aeromedical considerations regarding selective serotonin reuptake inhibitors (SSRIs) and aviator flight performance, particularly as assessed with neuropsychological testing. The papers and commentaries in this section encourage us to consider the complex variables effecting the decisions to administer pharmacological agents, as the impact of their use is weighed against the cognitive performance effects they may have in the operational environment. C1 Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA. USA, Aeromed Res Lab, Ft Rucker, AL USA. USAF, Res Lab, Brooks City Base, TX USA. RP Kautz, MA (reprint author), 6 E Schuyler Rd, Silver Spring, MD 20901 USA. EM makautz@prodigy.net NR 32 TC 0 Z9 4 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B107 EP B112 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800015 PM 17547311 ER PT J AU Kerick, SE Hatfield, BD Allender, LE AF Kerick, Scott E. Hatfield, Brad D. Allender, Laurel E. TI Event-related cortical dynamics of soldiers during shooting as a function of varied task demand SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE EEG; event-related spectral perturbation; theta; alpha; shooting performance; cognitive workload ID MENTAL WORKLOAD; EEG; PERFORMANCE; SYNCHRONIZATION; PATTERNS; MEMORY; OSCILLATIONS; MARKSMEN; ARCHERS; FLIGHT AB Introduction: Cortical dynamics of soldiers were examined during a reactive shooting task under varied task demands to investigate the effects of cognitive load on functional states of soldiers in real-time. Methods: Task demand factors consisted of task load (single, dual), decision load (no-decision, choice-decision), and target-exposure time (short, long). The Dismounted Infantryman Survivability and Lethality Testbed (DISALT) shooting simulator was programmed to generate the eight shooting scenarios and record weapon aim-point data while EEG was acquired continuously during each scenario. Event-related spectral perturbation (ERSP) was derived from single-trial data time-locked to the onsets of targets and peak amplitude and latency measures were analyzed in theta (4-7 Hz) and upper alpha (11-13 Hz) frequency bands. Results:The results are as follows: 1) a stimulus-evoked ERSP theta peak exhibited higher amplitude in the parietal region for choice- vs. no-decision scenarios and longer latency in the right central and temporal regions for dual- vs. single-task scenarios; and 2) ERSP alpha exhibited a progressive increase following the onset of targets with less of an increase in the left central region for dual- vs. single-task scenarios. Discussion: ERSP theta synchronization reflects stimulus encoding and exhibits increased peak power with more complex decision demands and longer latency with secondary task demands, whereas ERSP alpha synchronization reflects motor preparation and exhibits less of an increase with secondary task demands during reactive target shooting tasks. This research contributes the first study of cortical dynamics of soldiers performing a reactive shooting task and has implications for theories of attention and cognitive workload, human factors engineering, and soldier performance. C1 USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA. Univ Maryland, Program Neural & Cognit Sci, College Pk, MD 20742 USA. RP Kerick, SE (reprint author), USA, Ballist Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM skerick@arl.army.mil NR 38 TC 17 Z9 18 U1 0 U2 5 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B153 EP B164 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800024 PM 17547316 ER PT J AU Kratz, K Poppen, B Burroughs, L AF Kratz, Kris Poppen, Bradley Burroughs, Lisa TI The estimated full-scale intellectual abilities of US army aviators SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE general intelligence; Armed Services Vocational Aptitude Battery; Wechsler Adult Intelligence Scale; Multidimensional Aptitude Battery; US Air Force aviators ID PILOTS; INTELLIGENCE; PERFORMANCE; VALIDATION AB Introduction: The intellectual abilities of U.S. Army aviators have received a paucity of research attention over the years. The resultant lack of idiographic and aggregate data on this population has a direct impact on the neuropsychologist's ability to make clinical recommendations regarding a return to cognitive baseline following a neurological insult. Similarly, no research has assessed the generalizability of U.S. Air Force (USAF) research on premorbid aviator intellectual abilities to U.S. Army aviators. Methods: To establish estimates of general intellectual abilities in U.S. Army aviators, 1050 rated U.S. Army aviators without a head injury history were randomly selected from an aeromedical database and coupled with corresponding personnel data that contained Armed Services Vocational Aptitude Battery (ASVAB) scores. Estimated Wechsler Adult intelligence Scale-III (WAIS-III) and Multidimensional Aptitude Battery (MAB) full-scale intellectual (FSIQ) abilities were computed. Results: Mean U.S. Army aviator intellectual abilities were found to fall in the high average to superior range, with a notably large range of scores. Significant differences between these results and those of previously published USAF aviators on the MAB were found. Significant differences based on gender were absent. Significant differences based on rank were found. Discussion: Findings suggest estimated U.S. Army aviator intellectual abilities exceed previously published findings, with the wide range and non-normal distribution of scores suggesting idiographic baseline data would be clinically ideal for today's U.S. Army aviators. Clinical and operational benefits of establishing baseline cognitive abilities are presented. in the absence of baseline data, estimating the WAIS-III FSIQ score is a viable alternative in determining one's premorbid intellectual abilities. C1 Tripler Army Med Ctr, Honolulu, HI 96859 USA. Womack Army Med Ctr, Ft Bragg, NC USA. Argosy Univ, San Francisco, CA USA. RP Kratz, K (reprint author), POB 70660, Ft Bragg, NC 28307 USA. EM Kris.Kratz@us.army.mil NR 24 TC 2 Z9 3 U1 0 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B261 EP B267 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800035 PM 17547327 ER PT J AU Kratz, K Anderson, S Poppen, B AF Kratz, Kris Anderson, Sara Poppen, Bradley TI Premenstrual dysphoric disorder: Treatment with sertraline, neuropsychological effects, and flight status SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE menses; selective serotonin reuptake inhibitors; neuropsychological assessment; aviation performance ID AVIATORS AB Introduction: This case report reviews the aeromedical factors associated with considering a return to flight status of an aviator treated with sertraline 25 mg PO QD 5-7 d center dot mo(-1) for premenstrual dysphoric disorder (PMDD). Particular emphasis is given to her performance on serial neuropsychological assessments while both on and off of the medication. Case Presentation: Each testing occasion included a comprehensive battery of neuropsychological functioning, coupled with a blinded flight evaluation by a standardization pilot. The first testing occasion was on day 6 of menses while the aviator was taking 25 mg sertraline PO QD. The second testing occasion was completed I mo later, on day 6 of menses, while off the sertraline. The aviator's performance was compared with normative data at each testing occasion, as well as for possible significant change between testing occasions. Discussion: An interpretation of this aviator's overall neuropsychological performance is discussed, with particular attention given to the potential cognitive effects of sertraline. In light of previously published aeromedical considerations related to selective serotonin reuptake inhibitor use by aviators, the aeromedical considerations regarding this aviator's use of sertraline for PMDD are also highlighted. C1 Womack Army Med Ctr, Psychol Sect, Ft Bragg, NC 28307 USA. Tripler Army Med Ctr, Honolulu, HI USA. RP Kratz, K (reprint author), Womack Army Med Ctr, Psychol Sect, POB 70660, Ft Bragg, NC 28307 USA. EM Kris.Kratz@us.army.mil NR 16 TC 2 Z9 5 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B138 EP B143 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800022 PM 17547314 ER PT J AU Krueger, GP Banderet, LE AF Krueger, Gerald P. Banderet, Louis E. TI Implications for studying team cognition and team performance in network-centric warfare paradigms SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material DE team cognition; team performance; network-centric warfare; cognitive performance metrics; behavioral sciences measures of soldier performance ID ENVIRONMENTS AB Network-centric warfare's (NCW) information-rich systems involving sophisticated sensors, tracking systems, smart weapons, and enhanced digital communications threaten to overload combatants with voluminous amounts of data. It is unclear whether warfighters will perceive such extensive data as actionable information to which they will respond accurately in a timely enough manner. Members of small teams in command and control centers, operating in crew-served vehicles, or simply "grunting it out" as ground-pounding infantrymen, may be disparately separated by space, but will Communicate and be connected by electronic linkages, e.g., radio, text messages, situation displays, or global positioning data. However, team members will also have to remember shared mental models of tasks al hand, pay attention to and share common situation awareness in complex operational environments, perform team cognition and team coordination, and integrate both lower and higher cognitive processes with those of team behaviors. Such exceptional capabilities are required more now than ever before; such capabilities today are far from assured. After two workshops to establish performance metrics for assessing cognitive performance of military personnel in NCW, this preface introduces five manuscripts addressing team cognition and team performance from both a theoretical and a practical perspective. The authors of this preface question if NCW, and perhaps the politico-social ramifications of modern warfare, have already outstripped behavioral scientists' approach to researching team cognition and team performance-expertise that is so crucially needed for combatants on the rapidly changing 21(st)-century battlegrounds. C1 USA, Res Inst Environm Med, Natick, MA 01760 USA. Wexford Grp Int, Vienna, VA USA. RP Banderet, LE (reprint author), USA, Res Inst Environm Med, Natick, MA 01760 USA. EM Louis.Banderet@us.army.mil NR 26 TC 4 Z9 5 U1 0 U2 4 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B58 EP B62 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800009 PM 17547305 ER PT J AU Lieberman, HR Kramer, FM Montain, SJ Niro, P AF Lieberman, Harris R. Kramer, F. Matthew Montain, Scott J. Niro, Philip TI Field assessment and enhancement of cognitive performance: Development of an ambulatory vigilance monitor SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE actigraph; sleep; reaction time; motor activity; light; sound ID PHYSICAL-ACTIVITY; FATIGUE; SYSTEM AB Introduction: Limited opportunities to study human cognitive performance in non-laboratory, ambulatory Situations exist. However, advances in technology make it possible to extend behavioral assessments to the field. One of the first devices to measure human behavior in the field was the wrist-worn actigraph. This device acquires minute-by-minute information on an individual's physical activity and can distinguish sleep from waking, the most basic aspect of behavior. Methods: Our laboratory developed a series of wrist-worn devices, not much larger than a watch, which assess reaction time, vigilance and memory. The devices concurrently assess motor activity with greater temporal resolution than standard actigraphs. They also continuously monitor multiple environmental variables including temperature, humidity, sound, and light. Results: These monitors have been employed during training and simulated military operation!; to collect behavioral and environmental information that would typically be unavailable under such circumstances. Development of the vigilance monitor, and how each successive version extended capabilities of the device are described. Data from several studies are presented, including studies conducted in harsh field environments during a simulated infantry assault, an officer training course. Discussion: The monitors simultaneously documented environmental conditions, patterns of sleep and activity and effects of nutritional manipulations on cognitive performance. They provide a new method to relate cognitive performance to real world environmental conditions and assess effects of various interventions on human behavior in the field. They can also monitor cognitive performance in real time, and if it is degraded, attempt to intervene to maintain it. C1 USA, Expt Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. USA, Natick Res Dev & Engn Ctr, Sci & Technol Directorate, Natick, MA 01760 USA. RP Lieberman, HR (reprint author), USA, Expt Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA. EM harris.lieberman@na.amedd.army.mil NR 25 TC 9 Z9 10 U1 2 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B268 EP B275 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800036 PM 17547328 ER PT J AU Mahoney, CR Hirsch, E Hasselquist, L Lesher, LL Lieberman, HR AF Mahoney, Caroline R. Hirsch, Edward Hasselquist, Leif Lesher, Larry L. Lieberman, Harris R. TI The effects of movement and physical exertion on soldier vigilance SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE exercise; attention; cognition ID COGNITIVE PERFORMANCE; EXERCISE; WALKING; INFORMATION; RESPONSES; STATES; LOADS; MOOD; TASK AB Introduction: The effects of movement and physical exertion on cognitive processes remain unclear. Some studies report improvements in information processing while others report decrements or no change. To address relationships between movement, physical exertion, and cognitive performance, vigilance performance while soldiers walked with a heavy (40 kg) load was examined. Methods: Volunteers (n = 18) completed six 30-min test sessions on separate days: standing; walking with or without obstacles; while carrying a 40-kg load or no load. Suprathreshold visual, auditory or tactile stimuli were presented during the vigilance task. Dependent measures included accuracy, response time and distance traversed. Results: Volunteers reported higher perceived exertion (p < 0.05) when carrying a load and these ratings increased with time (p < 0.05). There were fewer correct responses on the vigilance task when carrying a load (p < 0.05) or when walking over obstacles (p < 0.05). Vigilance performance was superior with auditory compared with visual or tactile stimuli (p < 0.05). Less distance was covered when carrying a load (p < 0.05), traversing the course with obstacles (p < 0.05), and when responding to a tactile, compared with an auditory, stimulus (p < 0.05). Discussion: These results indicate walking around obstacles and the exertion of load carriage affect performance on the basic cognitive function of vigilance. Furthermore, they raise fundamental questions about whether cognitive performance data collected from sedentary, rested volunteers are applicable to individuals, including dismounted soldiers, engaged in tasks that concurrently require physical and cognitive resources. C1 USA, Soldier Ctr, Natick Soldier Ctr, Natick, MA 01760 USA. Sci Applicat Int Corp, Natick, MA USA. RP Mahoney, CR (reprint author), USA, Soldier Ctr, Natick Soldier Ctr, Natick, MA 01760 USA. EM caroline.mahoney@natick.army.mil NR 54 TC 11 Z9 12 U1 2 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B51 EP B57 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800008 PM 17547304 ER PT J AU Russo, MB AF Russo, Michael B. TI Recommendations for the ethical use of pharmacologic fatigue countermeasures in the US military SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE neuroethics; bioethics; pharmaceuticals; augmented cognition ID ENHANCING MOVEMENT; COSMETIC NEUROLOGY; CONTROVERSY; MENTATION; MOOD AB Culture and public opinion strongly influence debates on ethics-and what may be ethically acceptable to one nationality may be unacceptable to others. In military operations, some cognitive performance enhancement technologies are more ethically controversial than others. Of the enhancement technologies, use of psychoactive pharmaceuticals to alter behavior in healthy humans possibly presents the most controversial ethical challenge. Discussion of the bioethics of psychoactive enhancement agents is advisable because their military use is increasing while doctrine for their use remains limited. This paper focuses on psychoactive pharmaceuticals to enhance cognitive performance of military members. The topics addressed include: the use of psychoactive pharmaceuticals within a coalition framework; if ethical circumstances do exist for their use, what are these circumstances in clear and operationally useful terms; and guidelines to aid leaders in making ethically acceptable decisions. These questions should be answered: 1) Is use truly informed and voluntary - e.g., is an individual soldier requesting the medication with full understanding of its primary effects and side effects; 2) Is the medication safe for use in this individual, and safe within the context of the operational environment?; 3) Is the use of the medication consistent with its dosage and pharmacological function - is a sleep-inducing medication being used at appropriate doses, for a specified period, to facilitate sleep; and 4) Have available non-pharmacologic alternatives been fully utilized? This paper addresses a very narrow segment of the larger bioethics discussion: the use of pharmacologic enhancing agents in military members in times of war or national emergency. C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. RP Russo, MB (reprint author), USA, Aeromed Res Lab, POB 620577,6901 Farrel Rd, Ft Rucker, AL 36362 USA. EM michael.russo@us.army.mil NR 20 TC 11 Z9 13 U1 0 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B119 EP B127 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800017 PM 17547313 ER PT J AU Salas, E Rosen, MA Burke, CS Nicholson, D Howse, WR AF Salas, Eduardo Rosen, Michael A. Burke, C. Shawn Nicholson, Denise Howse, William R. TI Markers for enhancing team cognition in complex environments: The power of team performance diagnosis SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE team cognition; scenario based training; performance measurement ID SITUATION AWARENESS; MENTAL MODELS; KNOWLEDGE; COORDINATION AB Team cognition has been identified as a key component to achieve mission goals in dynamic, team-based, stressful, distributed and multicultural operations. Effective team performance in complex environments requires that team members hold a shared understanding of the task, their equipment, and their teammates. So, many of the simulation-based training (SET) systems and programs have been designed (partly) to enhance shared/team cognition. However, these simulation systems lack the sufficient robustness in their performance assessment tools or capabilities (if they have any) to allow for a rich and deep understanding of team cognition. Therefore, the purpose of this article is fourfold: 1) to present a brief account of team cognition; 2) to develop the concept of performance diagnosis and present SET as an approach to the performance diagnosis of team cognition; 3) to present a set of illustrative behavioral markers of team cognition; and 4) to explicate how these elements (performance diagnosis, team cognition, and SBT) can be leveraged to increase training effectiveness through the development of performance profiles - a rich, detailed, and informative set of metrics - and cognitive and behavioral indicators or illustrative markers of team cognition. Research needs are discussed in terms of realizing the potential of this approach in operational and embedded training contexts. C1 Univ Cent Florida, Inst Simulat & Training, Modeling & Simulat Grad Program, Orlando, FL 32826 USA. Army Res Inst, Ft Rucker, AL USA. RP Nicholson, D (reprint author), Univ Cent Florida, Inst Simulat & Training, Modeling & Simulat Grad Program, 3100 Technol Pkwy,Suite 319, Orlando, FL 32826 USA. EM dnichols@ist.ucf.edu NR 84 TC 28 Z9 30 U1 1 U2 17 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B77 EP B85 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800012 PM 17547308 ER PT J AU Schoomaker, EB AF Schoomaker, Eric B. TI Military medical research on cognitive performance: The warfighter's competitive edge SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material ID DECREMENTS; COMBAT C1 Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Schoomaker, EB (reprint author), USA, Med Res & Mat Command, Ft Detrick, MD USA. NR 11 TC 2 Z9 3 U1 1 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B4 EP B6 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800002 PM 17547298 ER PT J AU Smyth, CC AF Smyth, Christopher C. TI Sensitivity of subjective questionnaires to cognitive loading while driving with navigation aids: A pilot study SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE automated driving aids; perceived workload; situational awareness; subjective stress; cognitive compatibility; task interference ID PERFORMANCE; AUTOMATION AB Introduction: Developers of future forces are implementing automated aiding for driving tasks. In designing such systems, the effect of cognitive task interference an driving performance is important. The crew of such vehicles may have to occasionally perform communication and planning tasks while driving. Subjective questionnaires may aid researchers to parse out the sources of task interference in crew station designs. Method: In this preliminary study, sixteen participants drove a vehicle simulator with automated road-turn cues (i.e., visual, audio, combined, or neither) along a course marked on a map display while replying to spoken test questions (i.e., repeating sentences, math and logical puzzles, route planning, or none) and reporting other vehicles in the scenario. Following each trial, a battery of subjective questionnaires was administered to determine the perceived effects of the loading on their cognitive functionality. Results: Considering the performance, the participants drove significantly faster with the road-turn cues than with just the map. They recalled fewer vehicle sightings with the cognitive tests than without them. Questionnaire results showed that their reasoning was more straightforward, the quantity of information for understanding higher, and the trust greater with the combined cues than the map-only. They reported higher perceived workload with the cognitive tests. The capacity for maintaining situational awareness was reduced with the cognitive tests because of the increased division of attention and the increase in the instability, variability, and complexity of the demands. The association and intuitiveness of cognitive processing were lowest and the subjective stress highest for the route planning test. Finally, the confusability in reasoning was greater for the auditory cue with the route planning than the auditory cue without the cognitive tests. Conclusion: The subjective questionnaires are sensitive to the effects of the cognitive loading and, therefore, may be useful for guiding the development of automated aid designs. C1 USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21010 USA. RP Smyth, CC (reprint author), USA, Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21010 USA. EM csmyth@us.army.mil NR 33 TC 2 Z9 3 U1 0 U2 3 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B39 EP B50 PG 12 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800007 PM 17547303 ER PT J AU Stetz, MC Thomas, ML Russo, MB Stetz, TA Wildzunas, RM McDonald, JJ Wiederhold, BK Romano, JA AF Stetz, Melba C. Thomas, Maria L. Russo, Michael B. Stetz, Thomas A. Wildzunas, Robert M. McDonald, Joshua J. Wiederhold, Brenda K. Romano, James A., Jr. TI Stress, mental health, and cognition: A brief review of relationships and countermeasures SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Review DE battlefield; OEF; OIF; PTSD; depression; therapy; stress inoculation training ID CHRONIC MULTISYMPTOM ILLNESS; DECISION-MAKING; HIPPOCAMPAL VOLUME; MAJOR DEPRESSION; DISORDER; PERFORMANCE; COMBAT; MEMORY; VETERANS; TRAUMA AB Today's network-centric battlefield environment is highly stressful and cognitively demanding. Many warfighters are feeling overwhelmed and end up being medically evacuated from theater due to mental health problems [i.e., post traumatic stress disorder (PTSD) and depression]. Of a sample of troops evacuated for psychiatric reasons, 21% (106 out of 509) had psychiatric histories prior to deploying to the theater of operations. Most cases were either related to stress (i.e., PTSD, n = 33, 31%) or to depression (n = 72, 66%). Stress disorders and depression predominate among the psychiatric causes for medical evacuation. This review paper discusses stress theories as they pertain to warfighting, the types of stress and stress disorders most prevalent on modern battlefields, the relationships among stress, psychiatric disease, and cognitive performance, and potential methods to decrease some types of stress-related acute and chronic disorders (i.e., virtual-reality stress inoculation training). C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. Johns Hopkins Univ, Baltimore, MD USA. USA, Med Res & Mat Command, Ft Detrick, MD 21702 USA. Virtual Real Med Ctr, San Diego, CA USA. RP Stetz, MC (reprint author), USA, Aeromed Res Lab, POB 620577, Ft Rucker, AL 36362 USA. EM melba.stetz@us.army.mil NR 82 TC 26 Z9 31 U1 2 U2 9 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B252 EP B260 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800034 PM 17547326 ER PT J AU Thomas, ML Russo, MB AF Thomas, Maria L. Russo, Michael B. TI Neurocognitive monitors: Toward the prevention of cognitive performance decrements and catastrophic failures in the operational environment SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Editorial Material DE neurophysiological monitoring; augmented cognition; alertness; thalamus; electroencephalography; oculometrics; spatial disorientation AB Network-centric doctrine and the proposed C41SR (command, control, communications, computers, intelligence, surveillance and reconnaissance) distributions to the individual warfighter require that the cognitive performance, judgment, and decision making of warfighters must be sustained and effectively managed in the forward operating environment, where various physiological and psychological stressors abound, in order to reduce human errors and catastrophic failures. The U.S. Army Medical Research and Materiel Command (USAMRMC) established the Cognitive Performance, Judgment, and Decision-Making Research Program (CPJDRP) in 2004 to direct research to this issue. A Neurophysiological Measures and Cognition Focus Team (NMFCT) was formed to work with augmented cognition investigators and to specifically address the development of neurophysiological measures as potential monitors of alertness-cognitive state in warfighters. The USAMRMC approach complemented the Defense Advanced Research Projects Agency (DARPA) Augmented Cognition approach, which focused on the detection of workload-related impaired cognitive state, and subsequent modification of information flow through automation. In this preface, the premise for neurophysiological measures as neurocognitive monitors is explained using an example of.) neurophysiological index: the oculomotor measure, saccadic velocity. The progress of the NMFCT on the development of a neurocognitive monitor is described, as well as the recommendations of a 2005 USAMRMC/Telemedicine and Advanced Technology Research Center (TATRC)-sponsored workshop. Awareness of neurocognitive monitoring is discussed, as are future endeavors related to operational testing and fieldability. Four papers are summarized in this Neurophysiological Monitoring and Augmented Cognition section involving technologies to enhance cognitive performance in the operational environment: one on dynamic cortical electroencephalography, two on oculometrics, and one on a spatial orientation enhancement system. C1 USA, Aeromed Res Lab, Ft Rucker, AL 36362 USA. Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA. RP Russo, MB (reprint author), USA, Aeromed Res Lab, POB 620577, Ft Rucker, AL 36362 USA. EM Michael.Russo@us.army.mil NR 30 TC 9 Z9 10 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B144 EP B152 PG 9 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800023 PM 17547315 ER PT J AU Vo, AH Satori, R Jabbari, B Green, J Killgore, WDS Labutta, R Campbell, WW AF Vo, Alexander H. Satori, Roberto Jabbari, Bahman Green, Jody Killgore, William D. S. Labutta, Robert Campbell, William W. TI Botulinum toxin type-A in the prevention of migraine: A double-blind controlled trial SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article DE botulinum toxin type-A; migraine; headache; quality of life ID OF-LIFE QUESTIONNAIRE; CHRONIC DAILY HEADACHE; PROPHYLACTIC TREATMENT; OPEN-LABEL; MSQ AB Introduction: Migraine is a frequent medical complaint. In military populations, migraine can be detrimental to productivity and troop readiness, and can be disqualifying for service in some military duty specialties. This study assessed the effectiveness of botulinum neurotoxin type-A (BTX-A) in reducing the frequency of migraines in known migraineurs. Methods: There were 32 subjects (control = 17, test n = 15) who completed the assessment battery at baseline and monthly for 3 mo. Adult subjects with migraine headaches occurring more than 5 times/month were recruited and randomized to receive placebo saline injection vs. BTX-A. The primary efficacy parameter was the average frequency of headache days for 3 mo. Secondary outcome measures were severity of attacks and quality of life. Results: Quadratic trends were noted for headache severity (F (2,29) = 14.1, p = 0.001) and headache indexes (F (2,29) = 4.5, p = 0.042) for both groups, suggesting changes in severity of head pain and overall intensity of headaches experienced over time; however, results were not significant for headache frequency and severity between groups. Paired t-tests of the headache index scores for the control group revealed a significant increase from the first to the third follow-up periods (t = -2.58, p = 0.020). Such a trend was not observed for the BTX-A group. Both groups, however, reported similarly low to moderate quality of life as a result of their migraines. Conclusions: This controlled trial failed to demonstrate efficacy of BTX-A in reducing the frequency of migraine headaches. The pattern headache index in the botox group, however, suggested a protective effect for botox against the headache severity. C1 Univ Texas, Med Branch, AT&T Ctr Telehlth Res & Policy, Elect Hlth Network, Galveston, TX 77555 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. Martin Army Hosp, Ft Benning, GA USA. Yale Univ, Sch Med, New Haven, CT 06520 USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. Walter Reed Army Inst Res, Silver Spring, MD USA. RP Vo, AH (reprint author), Univ Texas, Med Branch, AT&T Ctr Telehlth Res & Policy, Elect Hlth Network, William C Levin Hall,Room 5-518,301 Univ Blvd, Galveston, TX 77555 USA. EM ahvo@utmb.edu NR 21 TC 18 Z9 20 U1 0 U2 7 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 2007 VL 78 IS 5 SU S BP B113 EP B118 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA 167OK UT WOS:000246460800016 PM 17547312 ER PT J AU Fleming, CD Edwards, CC Kirby, SD Maxwell, DM Potter, PM Cerasoli, DM Redinbo, MR AF Fleming, Christopher D. Edwards, Carol C. Kirby, Stephen D. Maxwell, Donald M. Potter, Philip M. Cerasoli, Douglas M. Redinbo, Matthew R. TI Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun SO BIOCHEMISTRY LA English DT Article ID ANHYDRIDE HYDROLASE ACTIVITY; HUMAN BUTYRYLCHOLINESTERASE; ACTIVE-SITE; MAMMALIAN CARBOXYLESTERASES; ORGANOPHOSPHORUS HYDROLASE; REACTION-PRODUCTS; SERINE PROTEASES; NERVE AGENTS; GUINEA-PIG; ACETYLCHOLINESTERASE AB The organophosphorus nerve agents sarin, soman, tabun, and VX exert their toxic effects by inhibiting the action of human acetylcholinesterase, a member of the serine hydrolase superfamily of enzymes. The current treatments for nerve agent exposure must be administered quickly to be effective, and they often do not eliminate long-term toxic side effects associated with organophosphate poisoning. Thus, there is significant need for effective prophylactic methods to protect at-risk personnel from nerve agent exposure, and protein-based approaches have emerged as promising candidates. We present the 2.7 A resolution crystal structures of the serine hydrolase human carboxylesterase 1 (hCE1), a broad-spectrum drug metabolism enzyme, in covalent acyl-enzyme intermediate complexes with the chemical weapons soman and tabun. The structures reveal that hCE1 binds stereoselectively to these nerve agents; for example, hCE1 appears to react preferentially with the 10(4)-fold more lethal P-S stereoisomer of soman relative to the P-R form. In addition, structural features of the hCE1 active site indicate that the enzyme may be resistant to dead-end organophosphate aging reactions that permanently inactivate other serine hydrolases. Taken together, these data provide important structural details toward the goal of engineering hCE1 into an organophosphate hydrolase and protein-based therapeutic for nerve agent exposure. C1 Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA. Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA. St Jude Childrens Hosp, Dept Mol Pharmacol, Memphis, TN 38105 USA. USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA. RP Redinbo, MR (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA. EM redinbo@unc.edu RI Potter, Philip/J-4515-2013 FU NCI NIH HHS [CA98468, R01 CA098468]; NINDS NIH HHS [NS58089, U01 NS058089, U01 NS058089-02] NR 55 TC 37 Z9 37 U1 3 U2 17 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD MAY 1 PY 2007 VL 46 IS 17 BP 5063 EP 5071 DI 10.1021/bi700246n PG 9 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA 159XB UT WOS:000245899900012 PM 17407327 ER PT J AU Shearer, JF Grodowitz, MJ McFarland, DG AF Shearer, Judy F. Grodowitz, Michael J. McFarland, Dwilette G. TI Nutritional quality of Hydrilla verticillata (L.f.) Royle and its effects on a fungal pathogen Mycoleptodiscus terrestris (Gerd.) Ostazeski SO BIOLOGICAL CONTROL LA English DT Article DE Hydrilla verticillata; Mycoleptodiscus terrestris; biocontrol; aquatic weed; plant nutrition; microsclerotia ID NITROGEN AVAILABILITY; FUSARIUM-CULMORUM; DISEASE; EXPRESSION; DISPERSAL; CULTURE; SPORES AB The submersed macrophyte, Hydrilla verticillata, was grown using different nutritional regimes under greenhouse conditions to obtain plants that were significantly different in percent nitrogen-free extract, crude fiber, ether-extractable compounds, crude protein, and ash in shoot tissue. Shoots were then challenged by the biological control fungal pathogen, Mycoleptodiscus terrestris, to determine the effects of plant nutritional status on disease severity, growth, and reproduction. Fourteen days post-inoculation, shoots from plants grown in high fertility sediment had significantly greater disease severity ratings than shoots from plants grown in low-fertility sediment. The nutritional status of the plants also impacted asexual reproduction of the pathogen by thin-walled conidia and melanized survival structures called microsclerotia. At 14 days post-inoculation, significantly higher numbers of conidia were produced in flasks containing hydrilla plants grown in high-fertility sediment. In contrast, microsclerotia increased almost fourfold in leaf tissues of hydrilla grown in low-fertility sediment. It appears from these studies that the nutritional condition of target plants cannot be excluded as an important factor in efficacy of pathogens used as biological control agents. The nutritional status of the host tissues influences M. terrestris ingress into host tissues, vegetative growth, production of secondary inoculum in the form of disseminative spores or conidia, and production of survival structures, the microsclerotia. (C) 2007 Elsevier Inc. All rights reserved. C1 USA, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Shearer, JF (reprint author), USA, Corps Engineers, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM Judy.F.Shearer@erdc.usace.army.mil NR 25 TC 6 Z9 7 U1 1 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1049-9644 J9 BIOL CONTROL JI Biol. Control PD MAY PY 2007 VL 41 IS 2 BP 175 EP 183 DI 10.1016/j.biocontrol.2007.02.003 PG 9 WC Biotechnology & Applied Microbiology; Entomology SC Biotechnology & Applied Microbiology; Entomology GA 164TG UT WOS:000246256700002 ER PT J AU Colyer, MH Bower, KS Ward, TP Hidayat, AA Subramanian, PS AF Colyer, Marcus H. Bower, Kraig S. Ward, Thomas P. Hidayat, Ahmad A. Subramanian, Prem S. TI Mitochondrial myopathy presenting with segmental corneal oedema and retrocorneal membrane SO BRITISH JOURNAL OF OPHTHALMOLOGY LA English DT Editorial Material ID KEARNS-SAYRE-SYNDROME; EXTERNAL OPHTHALMOPLEGIA; DECOMPENSATION; KERATOPATHY; ENDOTHELIUM C1 Walter Reed Army Med Ctr, Ophthalmol Clin 1F, Dept Surg, Ophthalmol Serv, Washington, DC 20307 USA. Armed Forces Inst Pathol, Washington, DC 20306 USA. Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA. RP Subramanian, PS (reprint author), Walter Reed Army Med Ctr, Ophthalmol Clin 1F, Dept Surg, Ophthalmol Serv, Washington, DC 20307 USA. EM prem.subramanian@na.amedd.army.mil NR 10 TC 3 Z9 3 U1 0 U2 0 PU B M J PUBLISHING GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND SN 0007-1161 J9 BRIT J OPHTHALMOL JI Br. J. Ophthalmol. PD MAY PY 2007 VL 91 IS 5 BP 696 EP 697 DI 10.1136/bjo.2006.101055 PG 2 WC Ophthalmology SC Ophthalmology GA 158XW UT WOS:000245829900038 PM 17446514 ER PT J AU Schofield, CM Murray, CK Horvath, EE Cancio, LC Kim, SH Wolf, SE Hospenthal, DR AF Schofield, Christina M. Murray, Clinton K. Horvath, Edward E. Cancio, Leopoldo C. Kim, Seuny H. Wolf, Steven E. Hospenthal, Duane R. TI Correlation of culture with histopathology in fungal burn wound colonization and infection SO BURNS LA English DT Article; Proceedings Paper CT 43rd Annual Meeting of the Infectious-Diseases-Society-of-America CY OCT 06-09, 2005 CL San Francisco, CA SP Infect Dis Soc Amer DE fungal; wound infection; culture; histopathology; burn ID EPIDEMIOLOGY AB An increasing number of burn wound infections are now due to fungi. Historically, therapy of fungal burn wound infections (FWI) consisted of debridement, topical antifungals and/or IV amphotericin B, negating the need to categorize disease further than fungal burn wound colonization (FWC) versus FWI. Newer antifungal agents have varying spectrums of activity, increasing the importance of identifying fungi, often to species. The records of patients admitted to our burn center from April 2000 to March 2005 were reviewed for fungi identified by histopathology. Wound specimens with fungi were classified as FWC or FWI and culture results were compared. The 1515 surgical wound tissue specimens were obtained from 2036 patients. Fungi were detected in the histopathology of 68 patients, 19 with FWI (3.8 FWI/year); 9 had corresponding growth on culture. Forty nine patients were identified with FWC, 16 with fungi recovered in corresponding cultures. FWI was associated with increased mortality (OR 25.3, GI 3.12-204.8). Correlation between histopathologic and culture identification of fungi was inconsistent. The etiology of FWI was diverse; fungi with known resistance to each of the three major classes of antifungals were isolated, suggesting empirical use of one class may be inadequate to treat FWI. Future burn wound management must seek to identify fungal pathogens to species. Published by Elsevier Ltd and ISBI. C1 Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. Wilford Hall USAF Med Ctr, Lackland AFB, TX 78236 USA. USA, Inst Surg Res, Ft Sam Houston, TX 78234 USA. RP Hospenthal, DR (reprint author), Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA. EM duane.hospenthal@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 NR 9 TC 34 Z9 38 U1 0 U2 0 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0305-4179 J9 BURNS JI Burns PD MAY PY 2007 VL 33 IS 3 BP 341 EP 346 DI 10.1016/j.burns.2006.08.040 PG 6 WC Critical Care Medicine; Dermatology; Surgery SC General & Internal Medicine; Dermatology; Surgery GA 160WJ UT WOS:000245972800010 PM 17321689 ER PT J AU Huntington, HP Boyle, M Flowers, GE Weatherly, JW Hamilton, LC Hinzman, L Gerlach, C Zulueta, R Nicolson, C Overpeck, J AF Huntington, Henry P. Boyle, Michelle Flowers, Gwenn E. Weatherly, John W. Hamilton, Lawrence C. Hinzman, Larry Gerlach, Craig Zulueta, Rommel Nicolson, Craig Overpeck, Jonathan TI The influence of human activity in the Arctic on climate and climate impacts SO CLIMATIC CHANGE LA English DT Article ID COD; NEWFOUNDLAND; GREENLAND; ATLANTIC; ALASKA; TUNDRA; DISTURBANCE; ECOSYSTEMS; COLLAPSE; DUST AB Human activities in the Arctic are often mentioned as recipients of climate-change impacts. In this paper we consider the more complicated but more likely possibility that human activities themselves can interact with climate or environmental change in ways that either mitigate or exacerbate the human impacts. Although human activities in the Arctic are generally assumed to be modest, our analysis suggests that those activities may have larger influences on the arctic system than previously thought. Moreover, human influences could increase substantially in the near future. First, we illustrate how past human activities in the Arctic have combined with climatic variations to alter biophysical systems upon which fisheries and livestock depend. Second, we describe how current and future human activities could precipitate or affect the timing of major transitions in the arctic system. Past and future analyses both point to ways in which human activities in the Arctic can substantially influence the trajectory of arctic system change. C1 Univ British Columbia, Inst Resources Environm & Sustainabil, Vancouver, BC V6S 1JK4, Canada. Simon Fraser Univ, Dept Earth Sci, Burnaby, BC V5A 1S6, Canada. Dartmouth Coll, Snow & Ice Div, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Univ New Hampshire, Dept Sociol, Durham, NH 03824 USA. Univ Alaska, Water & Environm Res Ctr, Fairbanks, AK 99775 USA. Univ Alaska, Dept Anthropol, Fairbanks, AK 99775 USA. San Diego State Univ, Dept Biol, Global Change Res Grp, San Diego, CA 92182 USA. Univ Massachusetts, Dept Nat Resources Conservat, Amherst, MA 01003 USA. Univ Arizona, Inst Study Planet Earth, Tucson, AZ 85721 USA. RP Huntington, HP (reprint author), 23834 The Clearing Dr, Eagle River, AK 99577 USA. EM hph@alaska.net; mboyle@ires.ubc.ca; gflowers@sfu.ca; weather@crrel.usace.army.mil; lawrence.hamilton@unh.edu; ffldh@uaf.edu; ffscg@uaf.edu; zulueta@mail.sdsu.edu; craign@forwild.umass.edu; jto@u.arizona.edu NR 58 TC 15 Z9 15 U1 0 U2 21 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0165-0009 EI 1573-1480 J9 CLIMATIC CHANGE JI Clim. Change PD MAY PY 2007 VL 82 IS 1-2 BP 77 EP 92 DI 10.1007/s10584-006-9162-y PG 16 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA 154PZ UT WOS:000245521100005 ER PT J AU Kratovil, T DeBerardinis, J Gallagher, N Luban, NLC Soldin, SJ Wong, ECC AF Kratovil, Tonya DeBerardinis, Jennifer Gallagher, Navi Luban, Naomi L. C. Soldin, Steven J. Wong, Edward C. C. TI Age specific reference intervals for soluble transferrin receptor (sTfR) SO CLINICA CHIMICA ACTA LA English DT Letter ID IRON-DEFICIENCY; SERUM C1 George Washington Univ, Sch Med & Hlth Sci, Childrens Natl Med Ctr, Div Lab Med, Washington, DC 20010 USA. George Washington Univ, Sch Med & Hlth Sci, Childrens Natl Med Ctr, Washington, DC USA. Walter Reed Army Med Ctr, Washington, DC 20307 USA. RP Wong, ECC (reprint author), George Washington Univ, Sch Med & Hlth Sci, Childrens Natl Med Ctr, Div Lab Med, 111 Michigan Ave NW, Washington, DC 20010 USA. EM ewong@cnmc.org NR 11 TC 13 Z9 13 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-8981 J9 CLIN CHIM ACTA JI Clin. Chim. Acta PD MAY 1 PY 2007 VL 380 IS 1-2 BP 222 EP 224 DI 10.1016/j.cca.2007.02.012 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA 170EP UT WOS:000246645500035 PM 17379200 ER PT J AU Bashaw, J Norris, S Weeks, S Trevino, S Adamovicz, JJ Welkos, S AF Bashaw, J. Norris, S. Weeks, S. Trevino, S. Adamovicz, J. J. Welkos, S. TI Development of in vitro correlate assays of immunity to infection with Yersinia pestis SO CLINICAL AND VACCINE IMMUNOLOGY LA English DT Article ID RECOMBINANT V-ANTIGEN; POLYHISTIDINE FUSION PEPTIDE; NECROSIS-FACTOR-ALPHA; INDUCED CELL-DEATH; PASTEURELLA-PESTIS; PNEUMONIC PLAGUE; ACTIVE IMMUNIZATION; PROTECTS MICE; POLYMORPHONUCLEAR NEUTROPHILS; PSEUDOMONAS-AERUGINOSA AB Pneumonic plague is a severe, rapidly progressing disease for which there is no effective vaccine. Since the efficacy of new vaccines cannot be tested in humans, it is essential to develop in vitro surrogate assays that are valid predictors of immunity. The F1 capsule antigen stimulates a protective immune response to most strains of Yersinia pestis. However, strains of Y. pestis that are F1(-) but still virulent have been isolated, and an in vitro assay, the results which can predict protection against both F1(+) and F1(-) strains, is needed. The virulence antigen (V) is an essential virulence factor of Y. pestis and stimulates protective antibodies. We investigated potential correlates of plague immunity that are based on anti-V antibody-mediated neutralization of Yersinia-induced macrophage cytotoxicity. The neutralizing activity of sera from mice vaccinated with an F1-V fusion candidate vaccine was determined. The decrease in the level of the apoptosis-specific enzyme caspase-3 significantly predicted survival in one- and two-dose vaccination experiments. Sera from F1-V-vaccinated nonhuman primates were evaluated with macrophage assays based on caspase-3 and on other markers manifested at the different stages in cell death. Using murine and human-derived macrophages in microscopic and fluorescence-activated-cell-sorting-based live/dead staining assays of terminal necrosis, we demonstrated a strong association between in vitro neutralization of macrophage cytotoxicity induced by serum-treated Yersinia and in vivo protection against lethal infection. These results provide a strong base for the development of reliable in vitro correlate bioassays that are predictive of protective immunity to plague. C1 USA, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA. RP Welkos, S (reprint author), USA, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA. EM susan.welkos@amedd.army.mil NR 53 TC 47 Z9 48 U1 1 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 1556-6811 J9 CLIN VACCINE IMMUNOL JI Clin. Vaccine Immunol. PD MAY PY 2007 VL 14 IS 5 BP 605 EP 616 DI 10.1128/CVI.00398-06 PG 12 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA 170RN UT WOS:000246681800017 PM 17376861 ER PT J AU Scafetta, N Moon, RE West, BJ AF Scafetta, Nicola Moon, Richard E. West, Bruce J. TI Fractal response of physiological signals to stress conditions, environmental changes, and neurodegenerative diseases SO COMPLEXITY LA English DT Article; Proceedings Paper CT Understanding Complex Systems Conference CY MAY, 2005 CL Univ Illinois Urbana Champaign, Urbana, IL HO Univ Illinois Urbana Champaign ID STRIDE-INTERVAL; TIME-SERIES; HUMAN GAIT AB In the past two decades the biomedical community has witnessed several applications of nonlinear system theory to the analysis of biomedical time series and the development of nonlinear dynamic models. The development of this area of medicine can best be described as nonlinear and fractal physiology. These studies have been intended to develop more reliable methodologies for understanding how biological systems respond to peculiar altered conditions induced by internal stress, environment stress, and/or disease. Herein, we summarize the theory and some of our results showing the fractal dependency on different conditions of physiological signals such as inter-breath intervals, heart inter-beat intervals, and human stride intervals. (C) 2007 Wiley Periodicals, Inc. C1 Duke Univ, Dept Phys, FG Hall Environm Lab, Durham, NC 27708 USA. Duke Univ, Free Electron Laser Lab, Durham, NC 27708 USA. Duke Univ, Dept Anesthesiol, FG Hall Environm Lab, Durham, NC 27708 USA. Duke Univ, Dept Med, FG Hall Environm Lab, Durham, NC 27708 USA. Duke Univ, Dept Phys, Durham, NC 27708 USA. USA, Res Off, Div Math, Res Triangle Pk, NC 27709 USA. RP Scafetta, N (reprint author), Duke Univ, Dept Phys, FG Hall Environm Lab, Durham, NC 27708 USA. RI West, Bruce/E-3944-2017; OI Scafetta, Nicola/0000-0003-0967-1911 NR 18 TC 18 Z9 19 U1 0 U2 2 PU JOHN WILEY & SONS INC PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 1076-2787 J9 COMPLEXITY JI Complexity PD MAY-JUN PY 2007 VL 12 IS 5 BP 12 EP 17 DI 10.1002/cplx.20183 PG 6 WC Mathematics, Interdisciplinary Applications; Multidisciplinary Sciences SC Mathematics; Science & Technology - Other Topics GA 171PH UT WOS:000246747400002 ER PT J AU Morscher, GN Singh, M Kiser, JD Freedman, M Bhatt, R AF Morscher, Gregory N. Singh, Mrityunjay Kiser, J. Douglas Freedman, Marc Bhatt, Ram TI Modeling stress-dependent matrix cracking and stress-strain behavior in 2D woven SiC fiber reinforced CVISiC composites SO COMPOSITES SCIENCE AND TECHNOLOGY LA English DT Article DE ceramic-matrix composites; matrix cracking; acoustic emission; stress-strain behavior ID SIC/SIC COMPOSITES; BRITTLE AB 2D woven Hi-Nicalon and Sylramic-iBN SiC fiber reinforced chemical vapor-infiltrated (CVI) SiC matrix composites were tested at room temperature with modal acoustic emission monitoring in order to determine relationships for stress-dependent matrix cracking. The Hi-Nicalon composites varied in the number of plies (1-36), specimen thickness, and constituent content. The Sylramic-iBN composites were fabricated with balanced and unbalanced 2D weaves in order to vary the fiber volume fraction in the orthogonal directions. Not surprisingly, matrix cracking stresses tended to be, but were not always, higher for composites with higher fiber volume fractions in the loading direction. It was demonstrated that simple relationships for stress-dependent matrix cracking could be related to the stress in the load-bearing CVI SiC matrix. For low-density composites, the 90 degrees minicomposites do not share significant loads and matrix cracking was very similar to single tow minicomposites. For higher-density composites, where significant load is carried by the 0 degrees minicomposites, matrix cracking was dependent on the unbridged "flaw" size, i.e., the 90 degrees tow size or unbridged transverse crack size. (c) 2006 Elsevier Ltd. All rights reserved. C1 NASA, Glenn Res Ctr, Ohio Aerosp Inst, Cleveland, OH 44135 USA. NASA, Glenn Res Ctr, QSS Grp, Cleveland, OH USA. USA, NASA, Glenn Res Ctr, Cleveland, OH USA. RP Morscher, GN (reprint author), NASA, Glenn Res Ctr, Ohio Aerosp Inst, Cleveland, OH 44135 USA. EM Gregory.N.Morscher@grc.nasa.gov NR 14 TC 33 Z9 39 U1 2 U2 18 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND SN 0266-3538 J9 COMPOS SCI TECHNOL JI Compos. Sci. Technol. PD MAY PY 2007 VL 67 IS 6 BP 1009 EP 1017 DI 10.1016/j.compscitech.2006.06.007 PG 9 WC Materials Science, Composites SC Materials Science GA 149RB UT WOS:000245163200009 ER PT J AU Taylor, DE Karasiev, VV Runge, K Trickey, SB Harris, FE AF Taylor, DeCarlos E. Karasiev, V. V. Runge, Keith Trickey, S. B. Harris, Frank E. TI Graded methods for rapid generation of quantum mechanical forces in molecular dynamics simulations SO COMPUTATIONAL MATERIALS SCIENCE LA English DT Article DE quantum forces; multi-scale simulations; molecular dynamics ID FUNCTIONALS AB Multi-scale simulations in materials and biomolecular systems are bottlenecked by the quantum mechanical calculation of forces in a chemically active region. As an alternative strategy to the relatively drastic simplifications involved in tight-binding or order-N QM methods, we suggest a sequence of QM and classical approximations graded by accuracy, hence computational cost. The strategy is to use the more costly but more accurate approximations at relatively infrequent simulation steps to reset the forces from the faster approximations of lower-grade accuracy. We illustrate with a severe test, comprised of only two grades, namely a published classical pair potential and a QM method independently calibrated to reproduce relevant coupled-cluster forces. (C) 2006 Elsevier B.V. All rights reserved. C1 Univ Florida, Quantum Theory Project, Dept Phys, Gainesville, FL 32611 USA. Univ Florida, Dept Chem, Gainesville, FL 32611 USA. USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Inst Venezolano Invest Cient, Ctr Quim, Caracas 1020A, Venezuela. Univ Utah, Dept Phys, Salt Lake City, UT 84112 USA. RP Trickey, SB (reprint author), Univ Florida, Quantum Theory Project, Dept Phys, Gainesville, FL 32611 USA. EM trickey@qtp.ufl.edu RI Karasiev, Valentin/J-2519-2012 OI Karasiev, Valentin/0000-0003-3445-6797 NR 18 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0927-0256 EI 1879-0801 J9 COMP MATER SCI JI Comput. Mater. Sci. PD MAY PY 2007 VL 39 IS 3 BP 705 EP 708 DI 10.1016/j.commatsci.2006.09.011 PG 4 WC Materials Science, Multidisciplinary SC Materials Science GA 176BC UT WOS:000247056700027 ER PT J AU Sturdivant, RX Hosmer, DW AF Sturdivant, Rodney X. Hosmer, David W., Jr. TI A smoothed residual based goodness-of-fit statistic for logistic hierarchical regression models SO COMPUTATIONAL STATISTICS & DATA ANALYSIS LA English DT Article DE hierarchical models; logistic regression; goodness-of-fit; Kernel smoothing; residuals ID MULTILEVEL MODELS; BINARY RESPONSES; TESTS AB We develop a goodness-of-fit measure with desirable properties for use in the hierarchical logistic regression setting. The statistic is an unweighted sum of squares (USS) of the kernel smoothed model residuals. We develop expressions for the moments of this statistic and create a standardized statistic with hypothesized asymptotic standard normal distribution under the null hypothesis that the model is correctly specified. Extensive simulation studies demonstrate satisfactory adherence to Type I error rates of the Kernel smoothed USS statistic in a variety of likely data settings. Finally, we discuss issues of bandwidth selection for using our proposed statistic in practice and illustrate its use in an example. (c) 2006 Elsevier B.V. All rights reserved. C1 US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. Univ Massachusetts, Dept Publ Hlth, Amherst, MA 01003 USA. RP Sturdivant, RX (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA. EM Rodney.Sturdivant@usma.edu NR 21 TC 4 Z9 4 U1 0 U2 6 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-9473 J9 COMPUT STAT DATA AN JI Comput. Stat. Data Anal. PD MAY 1 PY 2007 VL 51 IS 8 BP 3898 EP 3912 DI 10.1016/j.csda.2006.03.008 PG 15 WC Computer Science, Interdisciplinary Applications; Statistics & Probability SC Computer Science; Mathematics GA 162ZQ UT WOS:000246128500021 ER PT J AU Bertozzi, M Broggi, A Caraffi, C Del Rose, M Felisa, M Vezzoni, G AF Bertozzi, M. Broggi, A. Caraffi, C. Del Rose, M. Felisa, M. Vezzoni, G. TI Pedestrian detection by means of far-infrared stereo vision SO COMPUTER VISION AND IMAGE UNDERSTANDING LA English DT Article DE infrared; stereo; pedestrian detection AB This article presents a stereo system for the detection of pedestrians using far-infrared cameras. Since pedestrian detection in far-infrared images can be difficult in some environmental conditions, the system exploits three different detection approaches: warm area detection, edge-based detection, and disparity computation. A final validation process is performed using head morphological and thermal characteristics. Currently, neither temporal correlation, nor motion cues are used in this processing. The developed system has been implemented on an experimental vehicle equipped with two infrared cameras and preliminarily tested in different situations. (C) 2006 Elsevier Inc. All rights reserved. C1 Dip Ing Informaz, I-43100 Parma, Italy. USA, TARDEC, Warren, MI USA. RP Bertozzi, M (reprint author), Dip Ing Informaz, Parco Area Sci 181A, I-43100 Parma, Italy. EM bertozzi@ce.unipr.it; broggi@ce.unipr.it; caraffi@ce.unipr.it; mike.delrose@us.army.mil; vezzoni@ce.unipr.it OI Bertozzi, Massimo/0000-0003-1463-5384; Broggi, Alberto/0000-0002-0893-1331 NR 34 TC 50 Z9 53 U1 1 U2 9 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 1077-3142 J9 COMPUT VIS IMAGE UND JI Comput. Vis. Image Underst. PD MAY-JUN PY 2007 VL 106 IS 2-3 BP 194 EP 204 DI 10.1016/j.cviu.2006.07.016 PG 11 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA 171PJ UT WOS:000246747600005 ER PT J AU Oleng, NO Gribok, A Reifman, J AF Oleng, Nicholas O. Gribok, Andrei Reifman, Jaques TI Error bounds for data-driven models of dynamical systems SO COMPUTERS IN BIOLOGY AND MEDICINE LA English DT Article DE physiologic measurement predictions; bootstrap; error bounds; confidence interval; prediction interval; time-series data; dynamical systems ID BOOTSTRAP METHODS; TIME-SERIES; CONFIDENCE AB This work provides a technique for estimating error bounds about the predictions of data-driven models of dynamical systems. The bootstrap technique is applied to predictions from a set of dynamical system models, rather than from the time-series data, to estimate the reliability (in the form of prediction intervals) for each prediction. The technique is illustrated using human core temperature data, modeled by a hybrid (autoregressive plus first principles) approach. The temperature prediction intervals obtained are in agreement with those from the Camp-Meidell inequality. Moreover, as expected, the prediction intervals increase with the prediction horizon, time-series data variability, and model inaccuracy. Published by Elsevier Ltd. C1 USA, Med Res & Mat Command, Bioinformat Cell, Frederick, MD 21702 USA. RP Reifman, J (reprint author), USA, Med Res & Mat Command, Bioinformat Cell, Frederick, MD 21702 USA. EM jaques.reifman@us.army.mil NR 18 TC 7 Z9 7 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0010-4825 J9 COMPUT BIOL MED JI Comput. Biol. Med. PD MAY PY 2007 VL 37 IS 5 BP 670 EP 679 DI 10.1016/j.compbiomed.2006.06.005 PG 10 WC Biology; Computer Science, Interdisciplinary Applications; Engineering, Biomedical; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Computer Science; Engineering; Mathematical & Computational Biology GA 163NL UT WOS:000246166500010 PM 16895726 ER PT J AU Spoerl, E Mroehen, M Sliney, D Trokel, S Seiler, T AF Spoerl, Eberhard Mroehen, Michael Sliney, David Trokel, Stephen Seiler, Theo TI Safety of UVA-riboflavin cross-linking of the cornea SO CORNEA LA English DT Review DE cross-linking; keratoconus; UV; cornea; keratectasia; damage; collagen ID RADIATION-INDUCED CATARACT; IN-SITU KERATOMILEUSIS; ULTRAVIOLET-RADIATION; EXPOSURE TIME; COLLAGEN; KERATOCONUS; CYTOTOXICITY; ENDOTHELIUM; THERAPY; TISSUE AB Purpose: To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach. Methods: Comparison of the currently used technique with officially accepted guidelines regarding direct UV damage and the damage created by the induced free radicals (photochemical damage). Results: The currently used UVA radiant exposure of 5.4 mJ/cm(2) 2 and the corresponding irradiance of 3 mW/cm(2) is below the known damage thresholds of UVA for the corneal endothelium, lens, and retina, Regarding the photochemical damage caused by the free radicals, the damage thresholds for keratocytes and endothelial cells are 0.45 and 0.35 mW/cm(2), respectively. In a 400-mu m-thick cornea saturated with riboflavin, the irradiance at the endothelial level was 0.18 mW/cm(2), which is a factor of 2 smaller than the damage threshold. Conclusions: After corneal X-linking, the stroma is depopulated of keratocytes similar to 300 mu m deep. Repopulation of this area takes up to 6 months. As long as the cornea treated has a minimum thickness of 400 mu m (as recommended), the corneal endothelium will not experience damage, nor will deeper structures such as lens and retina. The light Source should provide a homogenous irradiance, avoiding hot spots. C1 IROC, CH-8002 Zurich, Switzerland. Univ Klinikum Dresden, Dept Ophthalmol, Dresden, Germany. USA, Laser Opt Radiat Program, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. Edward S Harkness Eye Inst, New York, NY USA. RP Seiler, T (reprint author), IROC, Stockerstr 37, CH-8002 Zurich, Switzerland. EM info@iroc.ch NR 36 TC 363 Z9 390 U1 5 U2 34 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0277-3740 J9 CORNEA JI Cornea PD MAY PY 2007 VL 26 IS 4 BP 385 EP 389 DI 10.1097/ICO.0b013e3180334f78 PG 5 WC Ophthalmology SC Ophthalmology GA 162PG UT WOS:000246099500001 PM 17457183 ER PT J AU Wanek, S Wolf, SE AF Wanek, Sandra Wolf, Steven E. TI Metabolic response to injury and role of anabolic hormones SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Article DE anabolic agents; hypermetabolism; insulin; severe burn ID SEVERELY BURNED CHILDREN; MUSCLE PROTEIN-SYNTHESIS; THERMAL-INJURY; GROWTH-HORMONE; HYPERMETABOLIC RESPONSE; PEDIATRIC-PATIENTS; INSULIN THERAPY; OXANDROLONE; CATABOLISM; PHASE AB Purpose of review To provide a short review of the literature describing the hypermetabolic response to injury and potential treatments. Associated findings include changes in inflammatory mediators and secreted hormones. Recent findings Treatments should be aimed at decreasing the response and potentially the use of anabolic agents. Of note, recent interest in the hyperglycemic response to injury and insulin treatment will be highlighted. Summary The current metabolic care of the burned patient including nutrition is now being unfolded. It is relatively clear that anabolic treatment should be considered in all those with severe injury. Timing of the treatment, however, is still a topic of discussion. C1 USA, Inst Surg Res, Burn Ctr, Ft Sam Houston, TX 78234 USA. Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78285 USA. RP Wolf, SE (reprint author), USA, Inst Surg Res, Burn Ctr, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234 USA. EM steven.wolf@amedd.army.mil OI Wolf, Steven/0000-0003-2972-3440 FU NIGMS NIH HHS [1R01 GM 063120-01] NR 54 TC 9 Z9 10 U1 1 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 1363-1950 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD MAY PY 2007 VL 10 IS 3 BP 272 EP 277 DI 10.1097/MCO.0b013e3280f31b17 PG 6 WC Endocrinology & Metabolism; Nutrition & Dietetics SC Endocrinology & Metabolism; Nutrition & Dietetics GA 165CJ UT WOS:000246281100002 PM 17414494 ER PT J AU Parampalli, A Eskridge, K Smith, L Meagher, MM Mowry, MC Subramanian, A AF Parampalli, Ananth Eskridge, Kent Smith, Leonard Meagher, Michael M. Mowry, Mark C. Subramanian, Anuradha TI Developement of serum-free media in CHO-DG44 cells using a central composite statistical design SO CYTOTECHNOLOGY LA English DT Article DE response surface method; media optimization ID RESPONSE-SURFACE METHODOLOGY; HAMSTER OVARY CELLS; MAJOR ENERGY-SOURCE; BOTULINUM NEUROTOXIN; CULTURE-MEDIUM; RECOMBINANT PROTEINS; MONOCLONAL-ANTIBODY; AMINO-ACIDS; OPTIMIZATION; GROWTH AB A serum free medium was developed for the production of recombinant antibody against Botulinum A (BoNTA) using dihydrofolate reductase deficient Chinese Hamster Ovary Cells (CHO-DG44) in suspension culture. An initial control basal medium was prepared, which was similar in composition to HAM's F12: IMDM (1:1) supplemented with insulin, transeferrin, selenium and a lipid mixture. The vitamin concentration of the basal medium was twice that of HAM's F12: IMDM (1:1). CHO-DG44 cells expressing S25 antibody grew from 2 x 10(5) cells to maximum cell density of 1.04 x 10(6) cells/ml after 5 days in this control medium. A central composite design was used to identify optimal levels and interaction among five groups of medium components. These five groups were glutamine, Essential Amino Acids (EAA), Non Essential Amino Acids (NEAA), Insulin, Transferrin, Selenium (ITS), and lipids. Fifty experiments were carried out in four batches, with two controls in each batch. There was little effect of ITS and Lipid concentrations over the range studied, and glutamine concentration showed a strong interaction with EAA. The optimal concentrations of the variables studied were 2.5 mM Glutamine, 7.4 mM (2x) EAA, 1.4 mM (0.5x) NEAA, 1x ITS supplement, 0.7x Lipids supplement. The maximum viable cell density attained in the optimized medium was 1.4 x 10(6) cells/ml, a 35% improvement over the control culture, while the final antibody titer attained was 22 +/- 3.4 mu g/mL, a 50% improvement. C1 Univ Nebraska, Dept Chem Engn, Lincoln, NE 68588 USA. USA, Med Res Inst Infect Dis, Toxicol & Aerobiol Div, Ft Detrick, MD 21702 USA. Univ Nebraska, Dept Stat, Lincoln, NE 68588 USA. RP Subramanian, A (reprint author), Univ Nebraska, Dept Chem Engn, 207 Othmer Hall,820 N 16th St, Lincoln, NE 68588 USA. EM asubramanian2@unl.edu NR 33 TC 20 Z9 22 U1 1 U2 13 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-9069 J9 CYTOTECHNOLOGY JI Cytotechnology PD MAY PY 2007 VL 54 IS 1 BP 57 EP 68 DI 10.1007/s10616-007-9074-3 PG 12 WC Biotechnology & Applied Microbiology; Cell Biology SC Biotechnology & Applied Microbiology; Cell Biology GA 179ET UT WOS:000247273100007 PM 19003018 ER PT J AU Sumner, JW Durden, LA Goddard, J Stromdahl, EY Clark, KL Reeves, WK Paddock, CD AF Sumner, John W. Durden, Lance A. Goddard, Jerome Stromdahl, Ellen Y. Clark, Kerry L. Reeves, Will K. Paddock, Christopher D. TI Gulf Coast Ticks (Amblyomma maculatum) and Rickettsia parkeri, United States SO EMERGING INFECTIOUS DISEASES LA English DT Article ID SPOTTED-FEVER; INFECTION AB Geographic distribution of Rickettsia parkeri in its US tick vector, Amblyomma maculatum, was evaluated by PCR. R. parkeri was detected in ticks from Florida, Georgia, Kentucky, Mississippi, Oklahoma, and South Carolina, which suggests that A. maculatum may be responsible for additional cases of R. parkeri rickettsiosis throughout much of its US range. C1 Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Atlanta, GA 30333 USA. Georgia So Univ, Statesboro, GA 30460 USA. Mississppi Dept Hlth, Jackson, MS USA. USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD USA. Univ N Florida, Jacksonville, FL USA. RP Paddock, CD (reprint author), Ctr Dis Control & Prevent, Infect Dis Pathol Branch, Mailstop G32,1600 Clifton Rd NE, Atlanta, GA 30333 USA. EM cdp9@cdc.gov NR 15 TC 70 Z9 73 U1 2 U2 11 PU CENTER DISEASE CONTROL PI ATLANTA PA ATLANTA, GA 30333 USA SN 1080-6040 J9 EMERG INFECT DIS JI Emerg. Infect. Dis PD MAY PY 2007 VL 13 IS 5 BP 751 EP 753 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 164DD UT WOS:000246212400014 PM 17553257 ER PT J AU Nowlin, TP Hall, DJ Purdom, EB Holtel, MR AF Nowlin, Thomas P. Hall, Daniel J. Purdom, Eric B. Holtel, Michael R. TI Pneumosinus dilatans SO ENT-EAR NOSE & THROAT JOURNAL LA English DT Article ID LARGE FRONTAL-SINUS AB Pneumosinus dilatans refers to an abnormally large aerated sinus; two other characteristic features of this disease are that the bony walls of the sinus are of normal thickness and there is no evidence of erosion. Most cases occur in the frontal sinuses. We describe a new case of pneumosinus dilatans in a 21-year-old woman. She required no treatment. C1 Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA. RP Hall, DJ (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM daniel.hall@amedd.army.mil NR 7 TC 4 Z9 4 U1 0 U2 0 PU VENDOME GROUP LLC PI NEW YORK PA 149 FIFTH AVE, 10TH FLOOR, NEW YORK, NY 10010 USA SN 0145-5613 J9 ENT-EAR NOSE THROAT JI ENT-Ear Nose Throat J. PD MAY PY 2007 VL 86 IS 5 BP 290 EP 291 PG 2 WC Otorhinolaryngology SC Otorhinolaryngology GA 176IG UT WOS:000247077600014 PM 17580810 ER PT J AU Lewis, JA Rao, KMK Castranova, V Vallyathan, V Dennis, WE Knechtges, PL AF Lewis, John A. Rao, K. Murali Krishna Castranova, Vince Vallyathan, Val Dennis, William E. Knechtges, Paul L. TI Proteomic analysis of bronchoalveolar lavage fluid: Effect of acute exposure to diesel exhaust particles in rats SO ENVIRONMENTAL HEALTH PERSPECTIVES LA English DT Article DE calprotectin; diesel; inflammation; macrophage; mass spectrometry; proteomics; SELDI ID INFLAMMATORY MEDIATORS; OVARIAN-CANCER; IN-VITRO; RELEASE; CALPROTECTIN; DESORPTION; LUNG AB BACKGROUND: Inhalation of diesel exhaust particles (DEPs) is characterized by lung injury and inflammation, with significant increases in the numbers of polymorphonuclear leukocytes and alveolar macrophages. This influx of cellular infiltrates is associated with the activation of multiple genes, including cytokines and chemokines, and the production of reactive oxygen species. OBJECTIVE: The pathogenesis of the lung injury is not fully understood, but alterations in the presence or abundance of a number of Proteins in the lung have been observed. Our objective in this study was to further characterize these changes and to ask whether additional changes could be discerned using modem proteomic techniques. METHODS: The present study investigate; global alterations in the proteome of bronchoalveolar lavage fluid taken from rats 1, 7, or 30 days after exposure to 5, 3 5, or 50 mg/kg of animal weight of DEPs. RESULTS: Analysis by surface-enhanced laser desorption/ionization-time of flight mass spectrometry identified two distinct peaks that appeared as an acute response postexposure at all doses in all animals. We identified these two peaks, with mass to charge ratios (m/z) of 9,100 and 10,100, as anaphylatoxin C3a and calgranulin A by additional mass spectral investigation using liquid chromatography coupled to mass spectrometry. CONCLUSIONS: With this approach, we found a number of inflammatory response proteins that may be associated with the early phases of inflammation in response to DEP exposure. Further studies are warranted to determine whether serum levels of these proteins could be markers of diesel exhaust exposure in workers. C1 USA, Ctr Environm Hlth Res, Ft Detrick, MD 21740 USA. NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 26505 USA. RP Lewis, JA (reprint author), USA, Ctr Environm Hlth Res, 568 Doughten Dr, Ft Detrick, MD 21740 USA. EM john.a.lewis1@us.army.mil NR 23 TC 18 Z9 18 U1 0 U2 9 PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE PI RES TRIANGLE PK PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233, RES TRIANGLE PK, NC 27709-2233 USA SN 0091-6765 J9 ENVIRON HEALTH PERSP JI Environ. Health Perspect. PD MAY PY 2007 VL 115 IS 5 BP 756 EP 763 DI 10.1289/ehp.9745 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA 163KZ UT WOS:000246159900036 PM 17520064 ER PT J AU Gong, P Inouye, LS Perkins, EJ AF Gong, Ping Inouye, Laura S. Perkins, Edward J. TI Comparative neurotoxicity of two energetic compounds, hexanitrohexaazaisowurtzitane and hexahydro-1,3,5-trinitro-1,3,5-triazine, in the earthworm Eisenia fetida SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE neurotoxicity; hexanitrohexaazaisowurtzitane; hexahydro-1,3,5-trinitro-1,3,5-triazine; Eisenia fetida; noninvasive electrophysiological technique ID LUMBRICUS-TERRESTRIS; CHRONIC TOXICITY; REPRODUCTION; BENOMYL; RDX; SURVIVAL; SEIZURES; EXPOSURE; SAVIGNY; CL-20 AB Hexanitrohexaazaisowurtzitane (CL-20) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), both energetic compounds, share some degree of structural similarity. A noninvasive electrophysiological technique was employed to assess the impacts of acute sublethal exposures on impulse conduction in medial (MGF) and lateral (LGF) giant nerve fiber pathways of the earthworm Eisenia fetida and to evaluate the reversibility of neurotoxic effects. Earthworms were exposed to either 0.02 to 2.15 mu g/cm(2) of CL-20 or 0.04 to 5.35 mu g/cm(2) of RDX, for 1 to 14 d, on moistened filter paper. Conduction velocities of MGF and LGF were recorded on a digital oscilloscope before and after exposure. Results indicate that at exposure levels as low as 0.02 mu g/cm(2) of CL-20 or 0.21 mu g/cm(2) of RDX, worms exhibited physiological impacts such as retardation, stiffness, and body shrink. Both MGF and LGF conduction velocities were negatively correlated with increasing doses of CL-20 or RDX. However, such neurotoxic effects were alleviated or even eliminated within a few days after exposed worms were transferred to an uncontaminated environment, indicating that the neurotoxicity is reversible even after 6-d exposure. The CL-20 is more potent than RDX, which is consistent with previous studies on lethality, growth, and reproduction endpoints in soil oligochaetes. C1 SpecPro, Vicksburg, MS 39180 USA. USA, Corps Engineers, Environm Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Gong, P (reprint author), SpecPro, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM ping.gong@erdc.usace.army.mil NR 29 TC 13 Z9 13 U1 0 U2 2 PU SOCIETY ENVIRONMENTAL TOXICOLOGY & CHEMISTRY-SETAC PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3367 USA SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAY PY 2007 VL 26 IS 5 BP 954 EP 959 DI 10.1897/06-361R.1 PG 6 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA 157VM UT WOS:000245749500017 PM 17521142 ER PT J AU Clark, BC Pierce, JR Manini, TM Ploutz-Snyder, LL AF Clark, Brian C. Pierce, Joseph R. Manini, Todd M. Ploutz-Snyder, Lori L. TI Effect of prolonged unweighting of human skeletal muscle on neuromotor force control SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE force control; steadiness; disuse; atrophy; H-reflex ID LOWER-LIMB SUSPENSION; MOTOR UNIT DISCHARGE; BED REST; OLD ADULTS; HAND MUSCLE; ECCENTRIC CONTRACTIONS; RESISTANCE EXERCISE; KNEE EXTENSOR; FLUCTUATIONS; ADAPTATIONS AB The purpose of this study was to determine the effect of 4 weeks of unilateral lower limb suspension (ULLS) on the fluctuations in motor output and the associated physiological changes. Subjects (n = 17) performed steady isometric plantarflexion (PF) and knee extension (KE) tasks, and KE shortening and lengthening contractions (intensity = 25% maximum). Spinal excitability of the soleus muscle was assessed via the H-reflex, muscle cross-sectional area (CSA) via MRI, along with EMG activity during the PF tasks. Following ULLS, isometric force fluctuations increased -12% for the PF, and 22% for the KE (P < 0.05), with no difference in the pattern of PF muscle activation Data for this project were collected in the Musculoskeletal Research Laboratory at Syracuse University. (P = 0.46). The unsteadiness of lengthening KE contractions increased 25% following ULLS (P=0.03), while KE steadiness during shortening contractions was not altered (P = 0.98). Significant correlations were observed between the percent changes in PF isometric force fluctuations and H-reflex (r = 0.49, P = 0.04), and between the PF isometric force fluctuations and PF CSA (r = -0.61, P < 0.01). These findings suggest the effects of unweighting on neuromotor performance are muscle group and contraction type dependent, and that the disuse-paradigm altering muscle CSA and spinal excitability may serve to mediate the associated loss of steadiness. C1 Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Interdisciplinary Inst Neuromusculoskeletal, Athens, OH 45701 USA. USA, Res Inst Environm Med, Military Performance Div, Natick, MA 01760 USA. Univ Florida, Coll Med, Dept Aging & Geriatr Res, Gainesville, FL 32608 USA. Syracuse Univ, Dept Exercise Sci, Syracuse, NY 13244 USA. RP Clark, BC (reprint author), Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Interdisciplinary Inst Neuromusculoskeletal, Athens, OH 45701 USA. EM clarkb2@ohio.edu NR 53 TC 23 Z9 24 U1 0 U2 6 PU SPRINGER PI NEW YORK PA 233 SPRING STREET, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD MAY PY 2007 VL 100 IS 1 BP 53 EP 62 DI 10.1007/s00421-007-0399-6 PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 164VN UT WOS:000246263000006 PM 17287986 ER PT J AU Xu, X Castellani, JW Santee, W Kolka, M AF Xu, Xiaojiang Castellani, John W. Santee, William Kolka, Margaret TI Thermal responses for men with different fat compositions during immersion in cold water at two depths: prediction versus observation SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE model; cold stress; hypothermia; thermoregulation; muscle blood flow ID HEAT-CONTENT; BLOOD-FLOW; BODY-FAT; TEMPERATURE; MODEL; INSULATION; EXPOSURE; HUMANS; HYPOTHERMIA; SIMULATION AB A cold thermoregulatory model (CTM) was applied to data from partially immersed subjects divided into normal (NF) or low fat (LF) groups in order to validate CTM during immersion at two depths and to examine mechanisms underlying the individual differences. CTM defines thermal characteristics, e.g. surface area and maximal shivering intensity, using height, weight, fat %, age and VO(2max). Ten clothed subjects, 5 NF (15-19%) and 5 LF (8.1-14.7%), were immersed in both 10 and 15 degrees C water at chest (CH) and waist (WA) level. Environmental and clothing inputs for CTM were weighted to adjust for the ratio of skin surface area covered by either air or water at various immersion depths. Predicted core temperature (T(c)) responses for each individual trial were compared with measured data. There were no significant differences (P > 0.05) between measured Tc and predicted T(c) for NF at all four conditions. In contrast, for the LF group, the predicted T(c) responses were all higher than measured (P < 0.05). However, predicted T(c) agreed closer with measured Tc for LF when leg muscle blood flow was increased in the simulation. This suggests that blood flow may contribute to the rapid decline in Tc observed in LF and its variance may cause in part the individual differences in Tc responses. CTM predicts Tc responses to immersion at various depths with acceptable accuracy for NF individuals in this study and can be adapted to non-uniform environments. C1 USA, Res Inst Environm Med, Biophys & Biomed Modeling Div, Natick, MA 01760 USA. USA, Res Inst Environm Med, Thermal & Mtn Med Div, Natick, MA 01760 USA. RP Xu, X (reprint author), USA, Res Inst Environm Med, Biophys & Biomed Modeling Div, Kansas St, Natick, MA 01760 USA. EM xiaojiang.xu@us.army.mil NR 37 TC 11 Z9 11 U1 1 U2 7 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1439-6319 J9 EUR J APPL PHYSIOL JI Eur. J. Appl. Physiol. PD MAY PY 2007 VL 100 IS 1 BP 79 EP 88 DI 10.1007/s00421-007-0393-z PG 10 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 164VN UT WOS:000246263000009 PM 17508227 ER PT J AU Kim, DH Berkowitz, MJ Bruck, EF Pino, EC AF Kim, David H. Berkowitz, Mark J. Bruck, Edward F. Pino, Edward C. TI Technique tip: Temporary tibiotalar pinning to facilitate hindfoot arthrodesis SO FOOT & ANKLE INTERNATIONAL LA English DT Editorial Material C1 Colorado Permanente Med Grp, Foot & Ankle Div, Denver, CO 80205 USA. Tripler Army Med Ctr, Honolulu, HI 96859 USA. RP Kim, DH (reprint author), Colorado Permanente Med Grp, Foot & Ankle Div, 2045 Franklin St, Denver, CO 80205 USA. EM david.h.kim@kp.org NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ORTHOPAEDIC FOOT & ANKLE SOC, INC PI SEATTLE PA 2517 EASTLAKE AVE EAST, STE 200, SEATTLE, WA 98102 USA SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD MAY PY 2007 VL 28 IS 5 BP 645 EP 645 DI 10.3113/FAI.2007.0645 PG 1 WC Orthopedics SC Orthopedics GA 166UH UT WOS:000246405400024 PM 17559780 ER PT J AU Komisar, JL AF Komisar, Jack L. TI Malaria vaccines SO FRONTIERS IN BIOSCIENCE-LANDMARK LA English DT Review DE malaria; vaccine; immunity; Plasmodium falciparum; clinical trials; review ID PLASMODIUM-FALCIPARUM MALARIA; APICAL MEMBRANE ANTIGEN-1; BLOOD-STAGE MALARIA; MEROZOITE SURFACE PROTEIN-1; RANDOMIZED CONTROLLED-TRIAL; PRIME-BOOST IMMUNIZATION; NEW-GUINEAN CHILDREN; PREGNANCY-ASSOCIATED MALARIA; YOUNG AFRICAN CHILDREN; NATURAL-KILLER-CELL AB More than 120 years after Alphonse Laveran's discovery of the blood-stage malaria parasite, there is no licensed malaria vaccine and malaria remains the world's most serious parasitic disease. Efforts to develop a vaccine have been thwarted by the complexity of the parasite's life cycle and the ability of the parasite to suppress and evade the immune response. Currently, there are several candidate vaccines in clinical trials and many more candidate vaccines that have shown efficacy in animal models or are based on studies of the immune responses of people who are resistant to malaria. The sequencing of the genomes of Plasmodium falciparum and Plasmodium yoelii yoelii in 2002 is expected to result in the identification of previously-unknown candidate vaccine targets from various stages of the Plasmodium life cycle. A great deal of effort is going into identifying the correlates of protection, potentially allowing more efficient testing of candidate vaccines in the future. The fact that a vaccine candidate has shown partial protection in field trials is a reason for hope that, with the proper effort and support, effective vaccines against malaria can be developed. C1 Walter Reed Army Inst Res, Komisar Div Malaria Vaccine Dev, Silver Spring, MD 20910 USA. RP Komisar, JL (reprint author), Walter Reed Army Inst Res, Komisar Div Malaria Vaccine Dev, 503 Robert Grant Ave, Silver Spring, MD 20910 USA. EM Jack.Komisar@na.amedd.army.mil NR 235 TC 6 Z9 6 U1 1 U2 6 PU FRONTIERS IN BIOSCIENCE INC PI IRVINE PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA SN 1093-9946 EI 1093-4715 J9 FRONT BIOSCI-LANDMRK JI Front. Biosci. PD MAY 1 PY 2007 VL 12 BP 3928 EP 3955 DI 10.2741/2361 PG 28 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA 163KG UT WOS:000246157900091 PM 17485348 ER PT J AU Bidus, MA Webb, JC Seidman, JD Rose, GS Boice, CR Elkas, JC AF Bidus, Michael A. Webb, Joel C. Seidman, Jeffrey D. Rose, G. Scott Boice, Charles R. Elkas, John C. TI Sustained response to bevacizumab in refractory well-differentiated ovarian neoplasms (vol 102, pg 5, 2006) SO GYNECOLOGIC ONCOLOGY LA English DT Correction C1 Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Washington, DC 20307 USA. Washington Hosp Ctr, Div Gynecol Oncol, Dept Obstet & Gynecol, Washington, DC 20010 USA. Washington Hosp Ctr, Dept Pathol, Washington, DC 20010 USA. RP Elkas, JC (reprint author), Walter Reed Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 6900 Georgia Ave NW, Washington, DC 20307 USA. EM John.Elkas@na.amedd.army.mil NR 1 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD MAY PY 2007 VL 105 IS 2 BP 559 EP 559 DI 10.1016/j.ygyno.2006.09.010 PG 1 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 164ER UT WOS:000246216800049 ER PT J AU Huang, J Mikszta, JA Ferriteri, MS Jiang, G Harvey, NG Dyas, B Roy, CJ Ulrich, RG Sullivan, VJ AF Huang, Joanne Mikszta, John A. Ferriteri, Matthew S. Jiang, Ge Harvey, Noel G. Dyas, Beverly Roy, Chad J. Ulrich, Robert G. Sullivan, Vincent J. TI Intranasal administration of dry powder anthrax vaccine provides protection against lethal aerosol spore challenge SO HUMAN VACCINES LA English DT Article DE anthrax; protective antigen; intranasal; spray-freeze-dried powder; vaccine; immune response; biodefense ID INHALATIONAL ANTHRAX; NASAL IMMUNIZATION; BACILLUS-ANTHRACIS; DELIVERY; MUCOSAL; ANTIGEN; IMMUNOGENICITY; FORMULATIONS; RESPONSES; CHITOSAN AB The use of an aerosolizable form of anthrax as a biological weapon is considered to be among the most serious bioterror threats. Intranasal (IN) delivery of a dry powder anthrax vaccine could provide an effective and non-invasive administration alternative to traditional intramuscular (IM) or subcutaneous (SC) injection. We evaluated a dry powder vaccine based on the recombinant Protective Antigen (rPA) of Bacillus anthracis for vaccination against anthrax via IN immunization in a rabbit model. rPA powders were formulated and administered IN using a prototype powder delivery device. We compared serum IgG and toxin neutralizing antibody (TNA) titers of rabbits immunized IN with 10 mu g rPA of a powder formulation with those immunized with the same dose of liquid rPA vaccine, delivered either IN or by IM injection. In addition, each group was tested for survival after aerosol spore challenge. Our results showed that IN vaccination with rPA powders elicited serum PA-specific IgG and TNA titers that were equivalent to those raised by liquid rPA administered IN. Serum PA-specific IgG and TNA titers after IN delivery were lower than for IM injection, however, after aerosol spore challenge, rabbits immunized IN with powders displayed 100% protection versus 63% for the group immunized IN with the liquid vaccine and 86% for the group immunized by IM injection. The results suggest that an IN powder vaccine based on rPA is at least as protective as a liquid delivered by IM injection. C1 BD Technol, Res Triangle Pk, NC 27709 USA. USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA. Amgen Inc, Thousand Oaks, CA 91320 USA. Tulane Natl Primate Res Ctr, Div Microbiol, Covington, LA USA. RP Sullivan, VJ (reprint author), BD Technol, 21 Davis Dr, Res Triangle Pk, NC 27709 USA. EM vince_sullivan@bd.com NR 23 TC 25 Z9 25 U1 0 U2 1 PU LANDES BIOSCIENCE PI GEORGETOWN PA 810 SOUTH CHURCH STREET, GEORGETOWN, TX 78626 USA SN 1554-8619 J9 HUM VACCINES JI Hum. Vaccines PD MAY-JUN PY 2007 VL 3 IS 3 BP 90 EP 93 PG 4 WC Biotechnology & Applied Microbiology; Immunology SC Biotechnology & Applied Microbiology; Immunology GA 164DG UT WOS:000246212700006 PM 17375001 ER PT J AU Geirhofer, S Tong, L Sadler, BM AF Geirhofer, Stefan Tong, Lang Sadler, Brian M. TI Dynamic spectrum access in the time domain: Modeling and exploiting white space SO IEEE COMMUNICATIONS MAGAZINE LA English DT Article AB Dynamic spectrum access is a promising approach to alleviate the spectrum scarcity that wireless communications face today. In short, it aims at reusing sparsely occupied frequency bands while causing no (or insignificant) interference to the actual licensees. This article focuses on applying this concept in the time domain by exploiting idle periods between bursty transmissions of multi-access communication channels and addresses WLAN as an example of practical importance. A statistical model based on empirical data is presented, and it is shown how to use this model for deriving access strategies. The coexistence of Bluetooth and WLAN is considered as a concrete example. C1 Cornell Univ, Adapt Commun & Signal Proc Grp, Ithaca, NY 14853 USA. USA, Res Lab, Adelphi, MD USA. RP Geirhofer, S (reprint author), Cornell Univ, Adapt Commun & Signal Proc Grp, Ithaca, NY 14853 USA. EM sg355@cornell.edu; lt35@cornell.edu; bsadler@arl.army.mil NR 15 TC 267 Z9 277 U1 1 U2 11 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0163-6804 EI 1558-1896 J9 IEEE COMMUN MAG JI IEEE Commun. Mag. PD MAY PY 2007 VL 45 IS 5 BP 66 EP 72 DI 10.1109/MCOM.2007.358851 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA 168PT UT WOS:000246537200008 ER PT J AU Ng, HY Wang, MR Li, DQ Wang, X Martinez, J Panepucci, RR Pathak, K AF Ng, Han-Yong Wang, Michael R. Li, Daqun Wang, Xuan Martinez, Jose Panepucci, Roberto R. Pathak, Kachesh TI 1x4 wavelength reconfigurable photonic switch using thermally tuned microring resonators fabricated on silicon substrate SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article DE microring resonator (MR); photonic switch; thermooptic; tuning AB We report a 1 x 4 wavelength reconfigurable photonic switch based on thermally tuned microring resonators (MRs) fabricated on a silicon-on-insulator substrate. The high refractive index of silicon facilitates the formation of highly confined optical waveguides and MRs. With a fabricated ring diameter of about 10 mu m, the MRs support 18-nm free-spectral range and 0.15-nm resonant spectral linewidth. Many wavelength channels can be selected through local thermal tuning of resonators for reconfigurable switching and wavelength-division multiplexing/demultiplexing. The switch response time is about 1 ms. The results suggest the feasibility of high port-count photonic circuitry with dynamic wavelength reconfiguration capability for the development of large-scale integrated photonics. C1 Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33146 USA. New Span Optotechnol Inc, Miami, FL 33173 USA. Florida Int Univ, Dept Elect & Comp Engn, Miami, FL 33174 USA. US Army Space & Missile Def Command, Huntsville, AL 35807 USA. RP Ng, HY (reprint author), Univ Miami, Dept Elect & Comp Engn, Coral Gables, FL 33146 USA. EM mwang@miami.edu NR 8 TC 21 Z9 21 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD MAY-JUN PY 2007 VL 19 IS 9-12 BP 704 EP 706 DI 10.1109/LPT.2007.895420 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA 180HG UT WOS:000247353100025 ER PT J AU Sobiesk, E Conti, G AF Sobiesk, Edward Conti, Gregory TI The cost of free web tools SO IEEE SECURITY & PRIVACY LA English DT Article C1 US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. RP Sobiesk, E (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA. EM edward.sobiesk@usma.edu; gregory-conti@usma.edu NR 10 TC 2 Z9 2 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA SN 1540-7993 J9 IEEE SECUR PRIV JI IEEE Secur. Priv. PD MAY-JUN PY 2007 VL 5 IS 3 BP 66 EP 68 DI 10.1109/MSP.2007.74 PG 3 WC Computer Science, Information Systems; Computer Science, Software Engineering SC Computer Science GA 174ZW UT WOS:000246982600013 ER PT J AU Kumar, M Garg, DP Zachery, RA AF Kumar, Manish Garg, Devendra P. Zachery, Randy A. TI A method for judicious fusion of inconsistent multiple sensor data SO IEEE SENSORS JOURNAL LA English DT Article DE Bayesian approach; decentralized fusion; sensor fusion; sequential fusion; spurious data ID VALIDATION AB One of the major problems in sensor fusion is that sensors frequently provide spurious observations which are difficult to predict and model. The spurious measurements from sensors must be identified and eliminated since their incorporation in the fusion pool might lead to inaccurate estimation. This paper presents a unified sensor fusion strategy based on a modified Bayesian approach that can automatically identify the inconsistency in sensor measurements so that the spurious measurements can be eliminated from the data fusion process. The proposed method adds a term to the commonly used Bayesian formulation. This term is an estimate of the probability that the data is not spurious, based upon the measured data and the unknown value of the true state. In fusing two measurements, it has the effect of increasing the variance of the posterior distribution when measurement from one of the sensors is inconsistent with respect to the other. The increase or decrease in variance can be estimated using the information theoretic measure "entropy." The proposed strategy was verified with the help of extensive computations performed on simulated data from three sensors. A comparison was made between two different fusion schemes: centralized fusion in which data obtained from all sensors were fused simultaneously, and a decentralized or sequential Bayesian scheme that proved useful for identifying and eliminating spurious data from the fusion process. The simulations verified that the proposed strategy was able to identify spurious sensor measurements and eliminate them from the fusion process, thus leading to a better overall estimate of the true state. The proposed strategy was also validated with the help of experiments performed using stereo vision cameras, one infrared proximity sensor, and one laser proximity sensor. The information from these three sensing sources was fused to obtain an occupancy profile of the robotic workspace. C1 Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27705 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Kumar, M (reprint author), Duke Univ, Dept Mech Engn & Mat Sci, Durham, NC 27705 USA. EM manish@duke.edu; dpgarg@duke.edu; randy.zachery@us.army.mil NR 33 TC 10 Z9 10 U1 0 U2 6 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1530-437X J9 IEEE SENS J JI IEEE Sens. J. PD MAY-JUN PY 2007 VL 7 IS 5-6 BP 723 EP 733 DI 10.1109/JSEN.2007.894905 PG 11 WC Engineering, Electrical & Electronic; Instruments & Instrumentation; Physics, Applied SC Engineering; Instruments & Instrumentation; Physics GA 172CB UT WOS:000246780600016 ER PT J AU Zhao, Q Sadler, BM AF Zhao, Qing Sadler, Brian M. TI A survey of dynamic spectrum access SO IEEE SIGNAL PROCESSING MAGAZINE LA English DT Article C1 Univ Calif Davis, ECE Dept, Davis, CA 95616 USA. Army Res Lab, Adelphi, MD USA. RP Zhao, Q (reprint author), Univ Calif Davis, ECE Dept, Davis, CA 95616 USA. EM qzhao@ece.ucdavis.edu RI Magazine, Signal Processing/E-9947-2015 NR 41 TC 1246 Z9 1310 U1 6 U2 30 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1053-5888 J9 IEEE SIGNAL PROC MAG JI IEEE Signal Process. Mag. PD MAY PY 2007 VL 24 IS 3 BP 79 EP 89 DI 10.1109/MSP.2007.361604 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA 167AM UT WOS:000246422800010 ER PT J AU Enaya, H Semenov, YLG Kim, KW Zavada, JM AF Enaya, Hani Semenov, Yuriy G. Kim, K. W. Zavada, John M. TI Electrical manipulation of nonvolatile spin cell based on diluted magnetic semiconductor quantum dots SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE magnetic logic devices; magnetic memories; semiconductor logic devices; semiconductor memories ID FERROMAGNETISM AB In this paper, electrical manipulation of a memory cell based on a semiconductor nanostructure consisting of a diluted magnetic semiconductor (DMS) quantum dot (QD) and a reservoir of itinerant holes separated by an energy barrier is investigated theoretically. The operating principle takes advantage of the paramagnetic-ferromagnetic (PM-FM) phase transition mediated by the itinerant holes in the DMS QD that can lead to electrically controlled Write/Erase operations. Nonvolatility can be achieved when the structure is properly designed to reach a thermodynamic equilibrium at both the PM and FM configurations (i.e., bistability). Assuming a parabolic confining potential in the QD, the performance characteristics of the proposed nanostructure are analyzed including the scalability and the lifetime. An advantage of this memory concept is the extremely small dissipative energy for Write/Erase functions due to the open-circuit nature of the process. A readout scheme enabling electrical detection, with the repetition rate up to the 10-100-MHz range, is also explored by utilizing only two contacts. Finally, a potential application of the proposed memory cell is discussed as a rudimentary device for logic AND and OR operations. C1 N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. RP Enaya, H (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA. NR 27 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD MAY PY 2007 VL 54 IS 5 BP 1032 EP 1039 DI 10.1109/TED.2007.894377 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 161RQ UT WOS:000246033700013 ER PT J AU Pearton, SJ Norton, DP Ivill, MP Hebard, AF Zavada, JM Chen, WM Buyanova, IA AF Pearton, Stephen J. Norton, David P. Ivill, Matt P. Hebard, Art F. Zavada, John M. Chen, Weimin M. Buyanova, Irina A. TI ZnO doped with transition metal ions SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article DE spintronies; ZnO ID DILUTED MAGNETIC SEMICONDUCTORS; ROOM-TEMPERATURE FERROMAGNETISM; LIGHT-EMITTING-DIODES; THIN-FILMS; ELECTRONIC-STRUCTURE; MATERIALS DESIGN; OXIDE SEMICONDUCTORS; OPTICAL-PROPERTIES; IMPLANTED ZNO; ZINC-OXIDE AB Spin-dependent phenomena in ZnO may lead to devices with new or enhanced functionality, such as polarized solid-state light sources and sensitive biological and chemical sensors. In this paper, we review the experimental results on transition metal doping of ZnO and show that the material can be made with a single phase at high levels of Co incorporation (similar to 15 at.%) and exhibits the anomalous Hall effect. ZnO is expected to be one of the most promising materials for room-temperature polarized light emission; but to date, we have been unable to detect the optical spin polarization in ZnO. The short spin relaxation time observed likely results from the Rashba effect. Possible solutions involve either cubic phase ZnO or the use of additional stressor layers to create a larger spin splitting in order to get a polarized light emission from these structures or to look at alternative semiconductors and fresh device approaches. C1 Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. Univ Florida, Dept Phys, Gainesville, FL 32611 USA. USA, Res Off, Res Triangle Pk, NC 27709 USA. Linkoping Univ, Dept Phys & Measurement Technol, S-58183 Linkoping, Sweden. RP Pearton, SJ (reprint author), Univ Florida, Dept Mat Sci & Engn, Gainesville, FL 32611 USA. EM spear@mse.ufl.edu RI Chen, Weimin/J-4660-2012; Buyanova, Irina/A-8924-2015 OI Chen, Weimin/0000-0002-6405-9509; Buyanova, Irina/0000-0001-7155-7103 NR 79 TC 76 Z9 76 U1 5 U2 25 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD MAY PY 2007 VL 54 IS 5 BP 1040 EP 1048 DI 10.1109/TED.2007.894371 PG 9 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA 161RQ UT WOS:000246033700014 ER PT J AU Torrieri, D Bakhru, K AF Torrieri, Don Bakhru, Kesh TI The maximin adaptive-array algorithm for direct-sequence systems SO IEEE TRANSACTIONS ON SIGNAL PROCESSING LA English DT Article DE adaptive array; direct sequence; interference suppression; spread spectrum AB An adaptive-array algorithm that suppresses interference in a direct-sequence system is proposed. The maximin algorithm differs from alternative algorithms in that it requires neither training sequences, directional information, decision-directed adaptation, nor elaborate computations such as eigenanalysis. The algorithm is derived and implementation details of the maximin processor in a direct-sequence system are explained. A convergence analysis establishes bounds on the adaptation constant and justifies the adaptation sequence used in the maximin algorithm. Simulation experiments confirm that the algorithm supplements the direct-sequence processing gain with a large amount of additional interference suppression. The simulation results demonstrate the robust performance of the algorithm for various array configurations, numbers of interference signals, interference levels, and fading conditions. C1 USA, Res Lab, Adelphi, MD 20783 USA. Johns Hopkins Univ, Baltimore, MD 21218 USA. Cub Def Applicat, San Diego, CA 92186 USA. San Diego State Univ, San Diego, CA 92182 USA. RP Torrieri, D (reprint author), USA, Res Lab, Adelphi, MD 20783 USA. EM dtorr@arl.army.mil; kesh.bakhru@cubic.com NR 14 TC 8 Z9 9 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855 USA SN 1053-587X J9 IEEE T SIGNAL PROCES JI IEEE Trans. Signal Process. PD MAY PY 2007 VL 55 IS 5 BP 1853 EP 1861 DI 10.1109/TSP.2006.890875 PN 1 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA 159YC UT WOS:000245902800023 ER PT J AU Qadri, F Ahmed, T Ahmed, F Bhuiyan, MS Mostofa, MG Cassels, FJ Helander, A Svennerholm, AM AF Qadri, Firdausi Ahmed, Tanvir Ahmed, Firoz Bhuiyan, M. Saruar Mostofa, Mohammad Golam Cassels, Frederick J. Helander, Anna Svennerholm, Ann-Mari TI Mucosal and systemic immune responses in patients with diarrhea due to CS6-expressing enterotoxigenic Escherichia coli SO INFECTION AND IMMUNITY LA English DT Article ID ANTIBODY-SECRETING CELL; HEAT-LABILE ENTEROTOXIN; COLONIZATION FACTOR CS6; VIBRIO-CHOLERAE O139; B-SUBUNIT VACCINE; MONOCLONAL-ANTIBODIES; ENTERIC INFECTIONS; ADULT VOLUNTEERS; IMMUNOGENICITY; SAFETY AB Colonization factor CS6 expressed by enterotoxigenic Escherichia coli (ETEC) is a nonfimbrial polymeric protein. A substantial proportion of ETEC strains isolated from patients in endemic settings and in people who travel to regions where ETEC is endemic are ETEC strains expressing CS6, either alone or in combination with fimbrial colonization factor CS5 or CS4. However, relatively little is known about the natural immune responses elicited against CS6 expressed by ETEC strains causing disease. We studied patients who were hospitalized with diarrhea (n = 46) caused by CS6-expressing ETEC (ETEC expressing CS6 or CS5 plus CS6) and had a disease spectrum ranging from severe dehydration (27%) to moderate or mild dehydration (73%). Using recombinant CS6 antigen, we found that more than 90% of the patients had mucosal immune responses to CS6 expressed as immunoglobulin (IgA) antibody-secreting cells (ASC) or antibody in lymphocyte supernatant (ALS) and that about 57% responded with CS6-specific IgA antibodies in feces. More than 80% of the patients showed IgA seroconversion to CS6. Significant increases in the levels of anti-CS6 antibodies of the IgG isotype were also observed in assays for ASC (75%), ALS (100%), and serum (70%). These studies demonstrated that patients hospitalized with the noninvasive enteric pathogen CS6-expressing ETEC responded with both mucosal and systemic antibodies against CS6. Studies are needed to determine if the anti-CS6 responses protect against reinfection and if protective levels of CS6 immunity are induced by vaccination. C1 ICDDR B, Lab Sci Div, Dhaka 1000, Bangladesh. Walter Reed Army Inst Res, Dept Enter Infect, Silver Spring, MD USA. Imp Coll London, Dept Infect Dis, London W2 1PG, England. Univ Gothenburg, Sahlgrenska Acad, Dept Microbiol & Immunol, S-40530 Gothenburg, Sweden. Univ Gothenburg, GUVAX, Vaccine Res Inst, S-40530 Gothenburg, Sweden. RP Qadri, F (reprint author), ICDDR B, Lab Sci Div, GPOB 128, Dhaka 1000, Bangladesh. EM fqadri@icddrb.org NR 43 TC 18 Z9 19 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 2007 VL 75 IS 5 BP 2269 EP 2274 DI 10.1128/IAI.01856-06 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 165YY UT WOS:000246345000021 PM 17296752 ER PT J AU Stewart, VA McGrath, SM Dubois, PM Pau, MG Mettens, P Shott, J Cobb, M Burge, JR Larson, D Ware, LA Demoitie, MA Weverling, GJ Bayat, B Custers, JHHV Dubois, MC Cohen, J Goudsmit, J Heppner, DG AF Stewart, V. Ann McGrath, Shannon M. Dubois, Patrice M. Pau, Maria G. Mettens, Pascal Shott, Joseph Cobb, Michelle Burge, J. Robert Larson, David Ware, Lisa A. Demoitie, Marie-Ange Weverling, Gerrit Jan Bayat, Babak Custers, Jerome H. H. V. Dubois, Marie-Claude Cohen, Joe Goudsmit, Jaap Heppner, D. Gray, Jr. TI Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone SO INFECTION AND IMMUNITY LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; RANDOMIZED CONTROLLED-TRIAL; CIRCUMSPOROZOITE PROTEIN; T-CELL; PROTECTIVE IMMUNITY; NEUTRALIZING ANTIBODIES; SEQUENTIAL IMMUNIZATION; RECOMBINANT PROTEIN; VECTORS; DNA AB The RTS,S/AS02A protein-based vaccine consistently demonstrates significant protection against infection with Plasmodium falciparum malaria and also against clinical malaria and severe disease in children in areas of endemicity. Here we demonstrate with rhesus macaques that priming with a replication-defective human adenovirus serotype 35 (Ad35)vector encoding circumsporozoite protein (CS) (Ad35.CS), followed by boosting with RTS,S in an improved MPL- and QS21-based adjuvant formulation, AS01B, maintains antibody responses and dramatically increases levels of T cells producing gamma interferon and other Th1 cytokines in response to CS peptides. The increased T-cell responses induced by the combination of Ad35.CS and RTS,S/AS01B are sustained for at least 6 months postvaccination and may translate to improved and more durable protection against P. falciparum infection in humans. C1 Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. Walter Reed Army Inst Res, Div Biometr, Silver Spring, MD USA. GlaxoSmithKline Biol, Rixensort, Belgium. Crucell Holland, Leiden, Netherlands. RP Stewart, VA (reprint author), Walter Reed Army Inst Res, Div Malaria Vaccine Dev, Silver Spring, MD USA. EM Ann.stewart@na.amedd.army.mil NR 42 TC 75 Z9 79 U1 1 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 2007 VL 75 IS 5 BP 2283 EP 2290 DI 10.1128/IAI.01879-06 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA 165YY UT WOS:000246345000023 PM 17307942 ER PT J AU Trainor, TE Parnell, GS Kwinn, B Brence, J Tollefson, E Downes, P AF Trainor, Timothy E. Parnell, Gregory S. Kwinn, Brigitte Brence, John Tollefson, Eric Downes, Pat TI The US army uses decision analysis in designing its US installation regions SO INTERFACES LA English DT Article DE military : cost effectiveness; decision analysis : applications AB Senior leaders responsible for managing US Army installations asked the United States Military Academy to analyze the regional organization of the US Army's Installation Management Agency (IMA) and recommend alternatives. They wanted an analysis of IMA's use of four geographical regions to manage installations in the continental United States. We interviewed stakeholders to identify the functions of the IMA regional organization. We used decision analysis to define the potential value added of various regional alternatives by measuring how well each alternative would perform the functions. The measures captured the effectiveness and efficiency of the regional organization for each function. We then developed and evaluated several regional alternatives (one region, two regions, three regions, four regions, five regions, and eight regions). Using decision analysis, we showed that four was a reasonable number of regions to manage installations effectively. We demonstrated that decreasing the number of regions below four would significantly reduce the value regions added to installation management and increasing the number would provide little additional benefit. C1 US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. Innovat Decis Inc, Centreville, VA 20120 USA. RP Trainor, TE (reprint author), US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA. EM tim.trainor@usma.edu; gregory.parnell@usma.edu; brigitte.kwinn@usma.edu; john.brence@us.army.mil; eric.tollefson@us.army.mil; patrick.downes@us.army.mil NR 9 TC 2 Z9 2 U1 0 U2 3 PU INFORMS PI HANOVER PA 7240 PARKWAY DR, STE 310, HANOVER, MD 21076-1344 USA SN 0092-2102 J9 INTERFACES JI Interfaces PD MAY-JUN PY 2007 VL 37 IS 3 BP 253 EP 263 DI 10.1287/inte.1060.0216 PG 11 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA 199BH UT WOS:000248670700008 ER PT J AU Conniff, DE Kiousis, PD AF Conniff, Dawn E. Kiousis, Panos D. TI Elastoplastic medium for foundation settlements and monotonic soil-structure interaction under combined loadings SO INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS LA English DT Article DE soil-structure interaction; plasticity; combined loads ID FINITE-ELEMENT ANALYSIS; BUILDINGS; CLAY AB Foundation settlements and soil-structure interaction are important problems to structural and geotechnical engineers. This study introduces a novel elastoplastic three-degree-of-freedom medium which models foundations settlements under combined loadings. A soil-structure interaction problem can then be solved by replacing the soil mass with this three-degree-of-freedom elastoplastic medium, thus reducing significantly the size of the problem. The model was developed by extending the classical plasticity concepts to the force-deformation level. Its ability to predict foundation deformations was evaluated using finite element solutions of a typical shallow foundation problem and was found reasonably accurate while producing significant time savings. Copyright (c) 2006 John Wiley & Sons, Ltd. C1 Colorado Sch Mines, Div Engn, Golden, CO 80401 USA. US Mil Acad, Dept Civil Engn & Mech, West Point, NY 10996 USA. RP Kiousis, PD (reprint author), Colorado Sch Mines, Div Engn, 1610 Illinois Str, Golden, CO 80401 USA. EM dawn.conniff@us.army.mil; pkiousis@mines.edu NR 25 TC 7 Z9 7 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI CHICHESTER PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND SN 0363-9061 J9 INT J NUMER ANAL MET JI Int. J. Numer. Anal. Methods Geomech. PD MAY PY 2007 VL 31 IS 6 BP 789 EP 807 DI 10.1002/nag.556 PG 19 WC Engineering, Geological; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA 167YD UT WOS:000246487600002 ER PT J AU Bessinger, GT Smith, SB Olivere, JW James, BL AF Bessinger, G. Todd Smith, Sidney B. Olivere, Joseph W. James, Bruce L. TI Benign hypersensitivity reactions to smallpox vaccine SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID UNITED-STATES; COMPLICATIONS AB Background With the reinstitution of smallpox vaccinations, physicians are seeing significant numbers of adverse events for the first time since the 1980s. The most common adverse events seen in our large military population are benign. We observed a clinically and histopathologically distinct reaction pattern that has not been fully characterized previously. Methods All smallpox-vaccinated patients at Fort Hood, Texas with adverse cutaneous reactions were referred to the dermatology clinic at Darnall Army Community Hospital. Patients were evaluated by a staff dermatologist who performed a skin biopsy and took clinical photographs. If the patients had intact vesicles or pustules, direct fluorescent antibody testing, viral and bacterial cultures, and polymerase chain reaction (PCR) assays were also performed. Results Three hypersensitivity reaction patterns were seen: exanthematous, erythema multiforme-like (EM-like), and urticarial. The patterns had distinct clinical and histopathologic findings. Of the 11,058 vaccinees, six had the exanthematous reaction pattern, two had the urticarial reaction pattern, and one had the EM-like pattern. Conclusions We describe a new exanthematous type of hypersensitivity reaction to the smallpox vaccine. Hypersensitivity reactions occur at a rate higher than previously reported. In a carefully screened military population, these three hypersensitivity reactions are much more common than life-threatening or serious reactions. Although the reactions have distinct clinical and pathologic features, they are all characterized by mild or absent systemic symptoms and a benign outcome. C1 Tripler Army Med Ctr, Dermatol Serv, Honolulu, HI 96859 USA. Darnall Army Community Hosp, Ft Hood, TX USA. RP Bessinger, GT (reprint author), Tripler Army Med Ctr, Dermatol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA. EM todd@bessinger.us NR 14 TC 4 Z9 4 U1 0 U2 2 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD MAY PY 2007 VL 46 IS 5 BP 460 EP 465 DI 10.1111/j.1365-4632.2006.02953.x PG 6 WC Dermatology SC Dermatology GA 163HO UT WOS:000246150900003 PM 17472671 ER PT J AU Parini, CL Mathis, D Leath, CA AF Parini, C. L. Mathis, D. Leath, C. A., III TI Occult metastatic lung carcinoma presenting as locally advanced uterine carcinosarcoma on positron emission tomography/computed tomography imaging SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER LA English DT Article DE metastatic lung adenocarcinoma; nonsmall cell lung cancer; positron emission tomography/computed tomography (PET/CT); uterine carcinosarcoma ID OVARIAN METASTASIS; FDG-PET; CANCER; ADENOCARCINOMAS AB Increasingly, positron emission tomography/computed tomography (PET/CT) is being used as a tumor surveillance modality for multiple tumor types. A 73-year-old postmenopausal female with stage IV nonsmall cell lung cancer presented after a PET/CT demonstrated focal uptake in the superior and lateral aspects of the uterus. The patient reported a history of intermittent postmenopausal bleeding and an endometrial biopsy documented uterine carcinosarcoma. Postoperative pathologic review and immunohistochemical staining with thyroid transcription factor-1 revealed metastatic adenocarcinoma consistent with her lung primary in her uterus and adnexa. Our case represents a rare occurrence in which lung cancer has metastasized to multiple female pelvic organs. Increasing use of PET/CT may lead to the discovery of occult metastases masquerading as a second primary malignancy. C1 Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Sam Houston, TX 78234 USA. Brooke Army Med Ctr, Dept Pathol, Ft Sam Houston, TX 78234 USA. RP Leath, CA (reprint author), Brooke Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA. EM charles.leath@amedd.army.mil OI Leath III, Charles/0000-0002-4034-6845 NR 16 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 1048-891X J9 INT J GYNECOL CANCER JI Int. J. Gynecol. Cancer PD MAY-JUN PY 2007 VL 17 IS 3 BP 731A EP 734 DI 10.1111/j.1525-1438.2007.00837.x PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA 167CX UT WOS:000246429600027 ER PT J AU Alvarado, JL Marsh, C Sohn, C Phetteplace, G Newell, T AF Alvarado, Jorge L. Marsh, Charles Sohn, Chang Phetteplace, Gary Newell, Ty TI Thermal performance of microencapsulated phase change material slurry in turbulent flow under constant heat flux SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article DE microencapsulated phase change material slurry; turbulence; supercooling; enhanced surface ID TRANSFER ENHANCEMENT; MINIEMULSION DROPLETS; PRESSURE-DROP; CIRCULAR TUBE; COOL STORAGE; SYSTEMS; CRYSTALLIZATION; MICROCAPSULES; SUSPENSIONS; EXCHANGERS AB Current cooling and heating distribution systems that use water as secondary fluid exhibit limited thermal capacity which can only be overcome by high flow rates and large (volume) capacity. A successful way to enhance the thermal capacity of secondary fluid systems is by incorporating microencapsulated phase change material (MPCM) slurry. However, a full understanding of the physical properties and heat transfer characteristics of MPCM slurry in the 2-8 degrees C range (35.5-46.5 degrees F) still is lacking. In the paper, latent heat of fusion, melting and freezing points, and temperature- and concentration-dependent viscosity data, are presented. Results indicate that selection of nucleating agent type and concentration is required to prevent the supercooling phenomenon. Pressure drop and convective heat transfer data were measured using a heat transfer loop operated at different flow rates and heat flux values. Results indicate that the phase change process and slurry mass fraction affect the heat transfer process. The paper also examines the impact of using enhanced surface tubing in combination with MPCM slurry under constant heat flux and turbulent conditions. (c) 2006 Elsevier Ltd. All rights reserved. C1 Texas A&M Univ, Dept Engn Technol & Ind Distribut, College Stn, TX 77843 USA. USA, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA. USA, Engineer Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA. Univ Illinois, Dept Mech & Ind Engn, Laser Aided Mat Proc Lab, Urbana, IL 61801 USA. RP Alvarado, JL (reprint author), Texas A&M Univ, Dept Engn Technol & Ind Distribut, 117 Thompson Hall,3367 TAMU, College Stn, TX 77843 USA. EM alvarado@entc.tamu.edu OI Alvarado, Jorge/0000-0002-4059-6588 NR 36 TC 97 Z9 107 U1 1 U2 34 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD MAY PY 2007 VL 50 IS 9-10 BP 1938 EP 1952 DI 10.1016/j.ijheatmasstransfer.2006.09.026 PG 15 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA 154JD UT WOS:000245502100029 ER PT J AU Segletes, SB AF Segletes, Steven B. TI Further development of a model for rod ricochet SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article DE ricochet; plastic hinge; analytical solution; long rod AB A ricochet model for long rods developed by the author has been revisited in search of solution efficiencies. By replacing a moment-of-momentum governing equation in the original model with a simpler minimization constraint, a solution technique has been developed that avoids the complexity of an iterative solution that characterized the original work. The revised model retains key elements of the original model, including: ricochet by way of plastic hinge formation; rod rebound from the target's ricochet surface; and target gouging as a means to redirect the target force's line of action. Finally, the ricochet equations are analytically rendered so as to give a keen sense of how the critical obliquity for ricochet varies as a function of the initial conditions of the ballistic engagement. (c) 2006 Elsevier Ltd. All rights reserved. C1 USA, Res Lab, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. RP Segletes, SB (reprint author), USA, Res Lab, Aberdeen Proving Ground, Aberdeen Proving Ground, MD 21005 USA. EM steven@arl.army.mil NR 6 TC 4 Z9 5 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PD MAY PY 2007 VL 34 IS 5 BP 899 EP 925 DI 10.1016/j.ijimpeng.2006.03.004 PG 27 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA 130OG UT WOS:000243808300004 ER PT J AU Morgan, CA Hazlett, G Baranoski, M Doran, A Southwick, S Loftus, E AF Morgan, Charles A., III Hazlett, Gary Baranoski, Madelon Doran, Anthony Southwick, Steven Loftus, Elizabeth TI Accuracy of Eyewitness Identification is significantly associated with performance on a standardized test of face recognition SO INTERNATIONAL JOURNAL OF LAW AND PSYCHIATRY LA English DT Article ID UNCONTROLLABLE STRESS; NEUROPEPTIDE-Y; TESTIMONY; EXPOSURE AB Objectives: This study assessed the relationship between Eyewitness Accuracy regarding a person met under conditions of high stress and performance on a standardized, neutral test of memory for human faces. Method: Fifty-three U.S. Army personnel were exposed to interrogation stress. Forty-eight hours later, participants were administered the Weschler Face Test and then asked to identify the one interrogator who they had encountered 48 h earlier. Results: A significant positive relationship was observed between performance on the Weschler Face Test and performance on the Eyewitness task. Inaccurate eyewitnesses exhibited more False Negative errors when performing the Weschler Face Test. Discussion: Trait ability to remember human faces may be related to how accurately people recall faces that are associated with highly emotional circumstances. Detection probability methods, such as ROC curve analyses, may be of assistance to forensic examiners, the police, and the courts, when assessing the probability that eyewitness evidence is accurate. (c) 2007 Elsevier Inc. All rights reserved. C1 Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA. Yale Univ, Sch Med, Sect Law & Psychiat, New Haven, CT 06520 USA. JFK Special Warfare Training Ctr & Sch, Ft Bragg, NC USA. Naval Air Stn, FASOTRAGRULANT, Brunswick, ME USA. Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA USA. RP Morgan, CA (reprint author), VA Connecticut Healthcare Syst, Natl Ctr PTSD, 116A, West Haven, CT 06516 USA. EM charles.a.morgan@yale.edu NR 18 TC 16 Z9 16 U1 2 U2 24 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0160-2527 J9 INT J LAW PSYCHIAT JI Int. J. Law Psychiatr. PD MAY-JUN PY 2007 VL 30 IS 3 BP 213 EP 223 DI 10.1016/j.ijlp.2007.03.005 PG 11 WC Law; Psychiatry SC Government & Law; Psychiatry GA 174HE UT WOS:000246932000005 PM 17449097 ER PT J AU Jordan, JL Ferranti, L Austin, RA AF Jordan, Jennifer L. Ferranti, Louis Austin, Ryan A. TI Equation of state of aluminum-iron oxide-epoxy composite SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DIRECT NUMERICAL-SIMULATION; WAVE PROPAGATION; COPPER-POWDER; PARTICLE; MIXTURES AB We report on the measurements of the shock equation of state (Hugoniot) of an Al/Fe2O3/epoxy composite, prepared by epoxy cast curing of powder mixtures. Explosive loading, with Baratol, trinitrotoluene (TNT), and Octol, was used for performing experiments at higher pressures, in which case shock velocities were measured in the samples and aluminum, copper, or polymethyl methacrylate (PMMA) donor material, using piezoelectric pins. The explosive loading of the metal donors (aluminum and copper) will be discussed. Gas gun experiments provide complementary lower pressure data in which piezoelectric polyvinylidene fluoride (PVDF) stress gauges were used to measure the input and propagated stress wave profiles in the sample and the corresponding shock propagation velocity. The results of the Hugoniot equation of state are compared with mesoscale finite-element simulations, which show good agreement. (c) 2007 American Institute of Physics. C1 USA, Res Lab, Eglin AFB, FL 32542 USA. Georgia Inst Technol, Sch Mat Sci & Engn, Atlanta, GA 30332 USA. Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA. Shocks Unltd, Albuquerque, NM 87114 USA. Univ Calif San Diego, Dept Aerosp Engn & Mech, La Jolla, CA 92093 USA. RP Jordan, JL (reprint author), USA, Res Lab, 2306 Perimeter Rd, Eglin AFB, FL 32542 USA. EM jennifer.jordan@eglin.af.mil RI Austin, Ryan/J-9003-2014; OI Jordan, Jennifer/0000-0002-4596-5872 NR 25 TC 12 Z9 14 U1 0 U2 14 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 2007 VL 101 IS 9 AR 093520 DI 10.1063/1.2719272 PG 9 WC Physics, Applied SC Physics GA 169BO UT WOS:000246567900034 ER PT J AU Devaney, JM Hoffman, EP Gordish-Dressman, H Kearns, A Zambraski, E Clarkson, PM AF Devaney, Joseph M. Hoffman, Eric P. Gordish-Dressman, Heather Kearns, Amy Zambraski, Edward Clarkson, Priscilla M. TI IGF-II gene region polymorphisms related to exertional muscle damage SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE insulin-like growth factor-II; single-nucleotide polymorphism ID GROWTH-FACTOR-II; SINGLE-NUCLEOTIDE POLYMORPHISMS; FAT-FREE MASS; SKELETAL-MUSCLE; ECCENTRIC EXERCISE; ACTN3 GENOTYPE; ELBOW FLEXORS; INSULIN; ADULT; REGENERATION AB We examined the association of a novel single-nucleotide polymorphism (SNP) in IGF-I (IGF-I -C1245T located in the promoter) and eight SNPs in the IGF-II gene region with indicators of muscle damage [strength loss, muscle soreness, and increases in circulating levels of creatine kinase (CK) and myoglobin] after eccentric exercise. We also examined two SNPs in the IGF binding protein-3 (IGFBP-3). The age, height, and body mass of the 151 subjects studied were 24.1 +/- 5.2 yr, 170.8 +/- 9.9 cm, and 73.3 +/- 17.0 kg, respectively. There were no significant associations of phenotypes with IGF-I. IGF-II SNP (G12655A, rs3213216) and IGFBP-3 SNP (A8618T, rs6670) were not significantly associated with any variable. The most significant finding in this study was that for men, IGF-II (C13790G, rs3213221), IGF-II (ApaI, G17200A, rs680), IGF-II antisense (IGF2AS) (G11711T, rs7924316), and IGFBP-3 (-C1592A, rs2132570) were significantly associated with muscle damage indicators. We found that men who were 1) homozygous for the rare IGF-11 C13790G allele and rare allele for the ApaI (G17200A) SNP demonstrated the greatest strength loss immediately after exercise, greatest soreness, and highest post-exercise serum CK activity; 2) homozygous wild type for IGF2AS (G1171IT, rs7924316) had the greatest strength loss and most muscle soreness; and 3) homozygous wild type for the IGF2AS G11711T SNP showed the greatest strength loss, highest muscle soreness, and greater CK and myoglobin response to exercise. In women, fewer significant associations appeared. C1 Univ Massachusetts, Dept Exercise Sci, Amherst, MA 01003 USA. Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA. USA, Environm Med Res Inst, Natick, MA 01760 USA. RP Clarkson, PM (reprint author), Univ Massachusetts, Dept Exercise Sci, Amherst, MA 01003 USA. EM clarkson@excsci.umass.edu NR 47 TC 31 Z9 35 U1 0 U2 21 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 2007 VL 102 IS 5 BP 1815 EP 1823 DI 10.1152/japplphysiol.01165.2006 PG 9 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 195KH UT WOS:000248410600014 PM 17289909 ER PT J AU Kenefick, RW Maresh, CM Armstrong, LE Riebe, D Echegaray, ME Castellani, JW AF Kenefick, R. W. Maresh, C. M. Armstrong, L. E. Riebe, D. Echegaray, M. E. Castellani, J. W. TI Rehydration with fluid of varying tonicities: effects on fluid regulatory hormones and exercise performance in the heat SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE fluid regulation; hydration state; dehydration; environment; osmotic load ID PLASMA-RENIN; BLOOD-VOLUME; VASOPRESSIN; ALDOSTERONE; RESPONSES; HUMANS; BODY; HYDRATION; HYPOHYDRATION; TEMPERATURE AB This study examined the effects of rehydration (Rehy) with fluids of varying tonicities and routes of administration after exercise-induced hypohydration on exercise performance, fluid regulatory hormone responses, and cardiovascular and thermoregulatory strain during subsequent exercise in the heat. On four occasions, eight men performed an exercise-dehydration protocol of similar to 185 min (33 degrees C) to establish a 4% reduction in body weight. Following dehydration, 2% of the fluid lost was replaced during the first 45 min of a 100-min rest period by one of three random Rehy treatments (0.9% saline intravenous; 0.45% saline intravenous; 0.45% saline oral) or no Rehy (no fluid) treatment. Subjects then stood for 20 min at 36 degrees C and then walked at 50% maximal oxygen consumption for 90 min. Subsequent to dehydration, plasma Na+, osmolality, aldosterone, and arginine vasopressin concentrations were elevated (P < 0.05) in each trial, accompanied by a -4% hemoconcentration. Following Rehy, there were no differences (P > 0.05) in fluid volume restored, post-rehydration (Post-Rehy) body weight, or urine volume. Percent change in plasma volume was 5% above pre-Rehy values, and plasma Na+, osmolality, and fluid regulatory hormones were lower compared with no fluid. During exercise, skin and core temperatures, heart rate, and exercise time were not different (P > 0.05) among the Rehy treatments. Plasma osmolality, Na+, percent change in plasma volume, and fluid regulatory hormones responded similarly among all Rehy treatments. Neither a fluid of greater tonicity nor the route of administration resulted in a more rapid or greater fluid retention, nor did it enhance heat tolerance or diminish physiological strain during subsequent exercise in the heat. C1 USA, Inst Environm Med, Thermal & Mt Med Div, Natick, MA 01760 USA. Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA. Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA. Univ Puerto Rico, Dept Biol, Cayey, PR USA. RP Kenefick, RW (reprint author), USA, Inst Environm Med, Thermal & Mt Med Div, Kansas St, Natick, MA 01760 USA. EM Robert.Kenefick@us.army.mil NR 30 TC 22 Z9 24 U1 0 U2 9 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD MAY PY 2007 VL 102 IS 5 BP 1899 EP 1905 DI 10.1152/japplphysiol.00920.2006 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA 195KH UT WOS:000248410600025 PM 17317877 ER PT J AU Bauer, TN Bodner, T Erdogan, B Truxillo, DM Tucker, JS AF Bauer, Talya N. Bodner, Todd Erdogan, Berrin Truxillo, Donald M. Tucker, Jennifer S. TI Newcomer adjustment during organizational socialization: A meta-analytic review of antecedents, outcomes, and methods SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Review DE socialization; newcomer adjustment; meta-analysis; organizational socialization tactics ID INFORMATION-SEEKING; LONGITUDINAL ANALYSIS; SELF-EFFICACY; WORK; TACTICS; JOB; COMMITMENT; ENTRY; EXPECTATIONS; FIT AB The authors tested a model of antecedents and outcomes of newcomer adjustment using 70 unique samples of newcomers with meta-analytic and path modeling techniques. Specifically, they proposed and tested a model in which adjustment (role clarity, self-efficacy, and social acceptance) mediated the effects of organizational socialization tactics and information seeking on socialization outcomes (job satisfaction, organizational commitment, job performance, intentions to remain, and turnover). The results generally supported this model. In addition, the authors examined the moderating effects of methodology on these relationships by coding for 3 methodological issues: data collection type (longitudinal vs. cross-sectional), sample characteristics (school-to-work vs. work-to-work transitions), and measurement of the antecedents (facet vs. composite measurement). Discussion focuses on the implications of the findings and suggestions for future research. C1 Portland State Univ, Sch Business Adm, Portland, OR 97207 USA. Portland State Univ, Dept Psychol, Portland, OR 97207 USA. USA, Res Inst, Infantry Forces Res Inst, Ft Benning, GA USA. RP Bauer, TN (reprint author), Portland State Univ, Sch Business, Portland, OR 97207 USA. EM TalyaB@sba.pdx.edu NR 112 TC 252 Z9 264 U1 13 U2 146 PU AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD MAY PY 2007 VL 92 IS 3 BP 707 EP 721 DI 10.1037/0021-9010.92.3.707 PG 15 WC Psychology, Applied; Management SC Psychology; Business & Economics GA 164TP UT WOS:000246257600009 PM 17484552 ER PT J AU Hill, MJ Uyehara, CFT Hashiro, GM Frattarelli, JL AF Hill, Micah J. Uyehara, Catherine F. T. Hashiro, Glenn M. Frattarelli, John L. TI The utility of serum leptin and follicular fluid leptin, estradiol, and progesterone levels during an in vitro fertilization cycle SO JOURNAL OF ASSISTED REPRODUCTION AND GENETICS LA English DT Article DE leptin; follicular fluid; infertility; in vitro fertilization; gonadotropins; pregnancy; implantation; estradiol; progesterone ID OVARIAN RESPONSE; PREGNANCY; EXPRESSION; INDUCTION; OVULATION; RECEPTOR; HORMONES; INDEX; MASS AB Purpose: To prospectively evaluate serum and follicular fluid leptin, estradiol, and progesterone levels during in vitro fertilization. Methods: Prospective observational study measuring serum levels at six points during the IVF cycle and follicular fluid at the time of retrieval. Results: Serum leptin and estradiol levels both significantly increased for the individual patients during the IVF stimulation process. None of the leptin levels differed based on pregnancy outcome. BMI significantly correlated with all leptin levels. Follicular fluid estradiol correlated with serum estradiol only in pregnant patients (r = 0.97, p < 0.01) and was unrelated in non-pregnant patients (r = -0.15, p = 0.81). Conclusion: Serum and follicular leptin levels are highly correlated. Leptin levels increase during the IVF cycle and vary between patients based on maternal BMI, but do not correlate with other serum hormone levels or pregnancy outcome. Pregnancy outcome success was reflected in the relationship between follicular fluid and serum levels of estradiol, independent of leptin levels. C1 Tripler Army Med Ctr, Honolulu, HI USA. Reprod Med Associates New Jersey, Somerset, NJ 08873 USA. RP Frattarelli, JL (reprint author), Tripler Army Med Ctr, Honolulu, HI USA. EM jfrattarelli@rmanj.com RI Hill, Micah/A-6777-2009 NR 15 TC 18 Z9 20 U1 0 U2 1 PU SPRINGER/PLENUM PUBLISHERS PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 1058-0468 J9 J ASSIST REPROD GEN JI J. Assist. Reprod. Genet. PD MAY PY 2007 VL 24 IS 5 BP 183 EP 188 DI 10.1007/s10815-007-9106-0 PG 6 WC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology SC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology GA 162SN UT WOS:000246109900006 PM 17333366 ER PT J AU Owens, BD Goss, TP AF Owens, B. D. Goss, T. P. TI The floating shoulder SO JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME LA English DT Letter C1 Keller Army Hosp, New York, NY USA. Univ Massachusetts, Sch Med, Amherst, MA 01003 USA. RP Owens, BD (reprint author), Keller Army Hosp, New York, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU BRITISH EDITORIAL SOC BONE JOINT SURGERY PI LONDON PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND SN 0301-620X J9 J BONE JOINT SURG BR JI J. Bone Joint Surg.-Br. Vol. PD MAY PY 2007 VL 89B IS 5 BP 708 EP 708 DI 10.1302/0301-620X.89B5.19685 PG 1 WC Orthopedics; Surgery SC Orthopedics; Surgery GA 184YX UT WOS:000247679600030 ER PT J AU Doona, CJ Baik, MY AF Doona, C. J. Baik, Moo-Yeol TI Molecular mobility in model dough systems studied by time-domain nuclear magnetic resonance spectroscopy SO JOURNAL OF CEREAL SCIENCE LA English DT Article DE starch; gluten; dough; water mobility distribution; time-domain NMR spectroscopy ID NMR RELAXATION DATA; WATER BINDING; STARCH; PROTON; H-1-NMR; GLUTEN AB The microscopic distribution and dynamic state of water and molecular mobility in various model systems are investigated using time-domain NMR spectroscopy. Starch and gluten showed different continuous distribution populations in T(21) (mu sec range, obtained from One pulse experiments) and T(22) (msee range, obtained from CPMG experiments) proving that starch and gluten have different water dynamics and molecular mobility. A starch/gluten mixture (76:12, w/w) and wheat flour dough exhibited similar patterns indicating that water and molecular mobilities in dough tended to be more representative of interactions with starch than gluten, even though both water starch and water-gluten interactions are occurring in wheat flour dough. Increasing the water content did not influence the continuous distribution pattern of T(21) but affected the relative amount of each fraction in T(21) (i.e. an increase of the more mobile fraction and a decrease of the less mobile fraction with increasing moisture). Added water has an important role in the more mobile fraction but not in the less mobile fraction, which is in lts range. This indicates that model food systems contain multiple microstructural domains with various water and molecular mobilities that show correspondingly different water dynamics. Therefore, the dispersion of various relaxation time constants helped identify the distribution of independent microstructural domains. The manipulation of the composition of the model food system influences the water dynamics and molecular mobility and provides a basis for the application of the microstructural domain concept to real food systems. (C) 2006 Elsevier Ltd. All rights reserved. C1 Kyung Hee Univ, Dept Food Sci & Biochem, Inst Life Sci & Resources, Yongin 449701, South Korea. USA, Combat Feeding Direct, Natick Soldier RDEC, Natick, MA 01760 USA. RP Baik, MY (reprint author), Kyung Hee Univ, Dept Food Sci & Biochem, Inst Life Sci & Resources, Yongin 449701, South Korea. EM mooyeol@khu.ac.kr OI Baik, Moo-Yeol/0000-0003-3779-3369 NR 27 TC 20 Z9 25 U1 0 U2 20 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0733-5210 J9 J CEREAL SCI JI J. Cereal Sci. PD MAY PY 2007 VL 45 IS 3 BP 257 EP 262 DI 10.1016/j.jcs.2006.07.015 PG 6 WC Food Science & Technology SC Food Science & Technology GA 167HW UT WOS:000246443400004 ER PT J AU Andzelm, J Rawlett, AM Orlicki, JA Snyder, JF AF Andzelm, Jan Rawlett, Adam M. Orlicki, Joshua A. Snyder, James F. TI Optical properties of phthalocyanine and naphthalocyanine compounds SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION LA English DT Article ID DENSITY-FUNCTIONAL THEORY; EXCITED-STATE DYNAMICS; SPECTROSCOPIC PROPERTIES; ELECTRONIC-STRUCTURE; THIN-FILMS; FREE-BASE; PHOTOELECTRON-SPECTROSCOPY; SILICON NAPHTHALOCYANINE; PHOTOPHYSICAL PROPERTIES; METAL PHTHALOCYANINES AB Phthalocyanines, naphthalocyanins, and their derivatives are frequently used as light modulating materials. These compounds, with their stable planar square structure and highly delocalized pi-electron system, are being used in numerous technological applications, such as pigments in chemical sensors, and more recently as photosensitizers for photodynamic therapy. The nonlinear optical properties (NLO) of these compounds are of particular importance. Using density functional method (DFT), we calculated the optical properties of phthalocyanine and naphthalocyanine complexes with Si as a central atom. We examined the effect of hydrophilic axial substituents and the size of polycyclic aromatic hydrocarbons surrounding the porphyrazine-Si kernel on the optical properties of title molecules. Both UV-vis and RSA spectra are calculated and are compared with available experimental results. The time-dependent DFT (TDDFT) with the B3LYP functional predicts that the characteristic UV-vis absorption maxima are blue-shifted; however, the relative error is almost constant for phthalocyanine and naphthalocyanine compounds. The TDDFT triplet-triplet absorption spectra of Si-phthalocyanine and Si-naphthalocyanine complexes reproduce experimental data well. C1 USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. Univ Zurich, CH-8057 Zurich, Switzerland. RP Andzelm, J (reprint author), USA, Res Lab, Aberdeen Proving Ground, MD 21005 USA. EM jandzelm@arl.army.mil RI Baldridge, Kim/E-6422-2011 OI Baldridge, Kim/0000-0001-7171-3487 NR 64 TC 27 Z9 27 U1 2 U2 42 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 1549-9618 EI 1549-9626 J9 J CHEM THEORY COMPUT JI J. Chem. Theory Comput. PD MAY-JUN PY 2007 VL 3 IS 3 BP 870 EP 877 DI 10.1021/ct700017b PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA 165CX UT WOS:000246282600024 PM 26627406 ER PT J AU Brown, RP Ubelaker, DH Schanfield, MS AF Brown, Robert P. Ubelaker, Douglas H. Schanfield, Moses S. TI Evaluation of Purkait's triangle method for determining sexual dimorphism SO JOURNAL OF FORENSIC SCIENCES LA English DT Article; Proceedings Paper CT 58th Annual Meeting of the American-Academy-of-Forensic-Sciences CY FEB, 2006 CL Seattle, WA SP Amer Acad Forens Sci DE forensic science; forensic anthropology; sex determination; femur ID FEMUR; WHITES; BLACKS AB The identification of sex from the skeleton is an important demographic assessment in medicolegal investigations. Rama Purkait developed a method for estimating sex using measurements from a triangle defined by three points on the proximal end of the femur using skeletal material from Bhopal, India. This method was tested with measurements on 200 Indo-European and African American adult femora from the Terry collection using discriminant function analysis to determine if Purkait's method was valuable for determining sex in Americans. A side-by-side analysis was conducted of Purkait's "triangle method" and the maximum diameter of the femoral head to determine their relative value in assessing sexual dimorphism. In the study sample a single variable from Purkait's method provided 85.5% prediction accuracy, similar to 87% for the head diameter. Combining threshold values for a single variable from Purkait's method and the femoral head diameter raised the predictability to greater than 90% for both sexes. C1 Smithsonian Inst, Dept Anthropol, NMNH, MRC 112, Washington, DC 20560 USA. USA, Criminal Invest Command, Ft Lewis, WA 98433 USA. George Washington Univ, Dept Forens Sci, Washington, DC 20052 USA. RP Brown, RP (reprint author), 22nd Mil Police Battal CID,POB 331009, Ft Lewis, WA 98433 USA. EM Robert.paul.brown@us.army.mil NR 8 TC 7 Z9 7 U1 1 U2 4 PU BLACKWELL PUBLISHING PI OXFORD PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 2007 VL 52 IS 3 BP 553 EP 556 DI 10.1111/j.1556-4029.2007.2007.00423.x PG 4 WC Medicine, Legal SC Legal Medicine GA 160LN UT WOS:000245942300006 PM 17456081 ER PT J AU Holcomb, FH Bush, J Knight, JL Whipple, J AF Holcomb, Franklin H. Bush, Joseph Knight, James L. Whipple, Jason TI Energy savings for silent Camp (TM) hybrid technologies SO JOURNAL OF FUEL CELL SCIENCE AND TECHNOLOGY LA English DT Article AB In military base'camp operations, the standard method of power generation is via the use of diesel generators. Unfortunately, these generators are often noisy and inefficient. Base camps could benefit from a "silent cap (TM) " operation, in which power is supplied via low-noise, low-impact methods such as fuel cells. Base camps have a variable load profile (they use more power during peak hours than at other times), and low loading levels (their generators' rated capacity is normally much greater than the load). Consequently, the generators only operate at peak efficiency for short, intermittent intervals. Under these conditions, the generators' fuel use is less than optimal, they require frequent maintenance, and their life cycle is shortened. Approximately 60-70% of maintenance problems for diesel generators are directly attributable to "wetstacking, " which occurs when these generators are operated at less than 50% of their rated capacity (Commerce Business Daily, Feb. 16, 2000). One solution to address these issues is to institute a hybrid power system, consisting of: a fuel cell (with inverter), an electrolyzer and a metal hydride storage system, all coupled and packaged with a diesel generator. This system would enable the generator to operate at peak efficiency while increasing the capabilities of the power generation system. Such a system could offer numerous benefits over the base case stand alone generator as follows: (1) the ability for Silent Camp (TM) operation (by using the fuel cell output exclusively); (2) potential.for reducedfuel consumption; (3) reduced instances of "wetstacking, " thereby decreasing generator maintenance costs; (4) the ability to have backup power fromfiriel cells; (5) refueling capability for hydrogen devices or vehicles; and (6) reduced environmental impact in terms of pollutant, acoustic, and thermal emissions. C1 USA, ERDC, CERL, Champaign, IL 61822 USA. Univ Illinois, Urbana, IL 61801 USA. RP Holcomb, FH (reprint author), USA, ERDC, CERL, Champaign, IL 61822 USA. NR 10 TC 0 Z9 0 U1 1 U2 2 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA THREE PARK AVE, NEW YORK, NY 10016-5990 USA SN 1550-624X J9 J FUEL CELL SCI TECH JI J. Fuel Cell Sci. Technol. PD MAY PY 2007 VL 4 IS 2 BP 134 EP 137 DI 10.1115/1.2714566 PG 4 GA 180JQ UT WOS:000247359600005 ER PT J AU Long, CE Resio, DT AF Long, Charles E. Resio, Donald T. TI Wind wave spectral observations in Currituck Sound, North Carolina SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID GENERATED GRAVITY-WAVES; NONLINEAR ENERGY FLUXES; EQUILIBRIUM-RANGE; DIRECTIONAL SPECTRA; OCEAN WAVES; DEPTH; CONSTANT; WATER; BUOY AB [1] We examine a set of 1626 high-resolution frequency-direction wind wave spectra and collocated winds collected during a 7-month period at a site in Currituck Sound, North Carolina, in terms of one-dimensional spectral structure and directional distribution functions. The data set includes cases of shore-normal winds in broad-fetch conditions as well as winds oblique to the basin geometry, with all fetches of order 10 km or less. Using equilibrium-range scaling, all one-dimensional spectra have a spectral peak region, an equilibrium range of finite bandwidth following an f(-4) slope at slightly higher frequencies, and a high-frequency tail that falls off more rapidly than f(-4). For shore-normal winds, spectral peakedness appears to be high and approximately constant for young waves, low and approximately constant for old waves, and steeply graded for intermediate inverse wave ages in the range 1.0 < u(10)/ c(p) < 1.7. Equilibrium-range bandwidth seems to be narrow for young waves and increases with increasing wave age. Directional distribution functions in shore-normal winds are symmetric about the wind direction, narrow at spectral peaks, and broad at high frequencies with distinct directionally bimodal peaks, consistent with other observations. In oblique-wind cases, directional distribution functions are asymmetric and directionally sheared in spectral peak regions, with peak directions aligned with longer fetch directions. At high frequencies, directional distributions are more nearly symmetric about the wind direction. One-dimensional spectra tend to have reduced spectral peakedness and highly variable equilibrium-range bandwidths in oblique-wind conditions, clearly indicating a more complex balance of source terms in these cases than in the more elementary situation of shore-normal winds. These complications are not without consequence in wave modeling, as any bounded or semibounded lake or estuary will be subject to oblique winds, and current operational models do not deal well with conditions like those we find here. C1 USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA. RP Long, CE (reprint author), USA, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA. EM charles.e.long@erdc.usace.army.mil; donald.t.resio@erdc.usace.army.mil NR 33 TC 30 Z9 30 U1 1 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAY 1 PY 2007 VL 112 IS C5 AR C05001 DI 10.1029/2006JC003835 PG 21 WC Oceanography SC Oceanography GA 165LQ UT WOS:000246307400006 ER PT J AU Gutteridge, CE Hoffman, MM Bhattacharjee, AK Gerena, L AF Gutteridge, Clare E. Hoffman, Marshall M. Bhattacharjee, Apurba K. Gerena, Lucia TI Synthesis and antimalarial activity of 7-benzylamino-1-isoquinolinamines SO JOURNAL OF HETEROCYCLIC CHEMISTRY LA English DT Article ID PARASITE PLASMODIUM-FALCIPARUM; IN-VITRO; MALARIA; DERIVATIVES; CHALCONES; LICOCHALCONE; ANTAGONISTS; AGENT; VIVO AB Computer modelling suggests that 7-benzylamino-1-isoquinolinamines should mediate antimalarial effects by a mechanism distinct from that employed by existing antimalarial drugs. A series of these compounds was prepared in seven synthetic steps, via reductive amination of 1,7-isoquinolinediamine. In vitro efficacy testing of the novel compounds against Plasmodium falciparum revealed them to be potent antimalarial agents. C1 USN Acad, Dept Chem, Annapolis, MD 21402 USA. Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA. RP Gutteridge, CE (reprint author), USN Acad, Dept Chem, Annapolis, MD 21402 USA. NR 24 TC 5 Z9 6 U1 0 U2 1 PU HETERO CORPORATION PI PROVO PA PO BOX 170, PROVO, UT 84603-0170 USA SN 0022-152X J9 J HETEROCYCLIC CHEM JI J. Heterocycl. Chem. PD MAY-JUN PY 2007 VL 44 IS 3 BP 633 EP 637 PG 5 WC Chemistry, Organic SC Chemistry GA 170OU UT WOS:000246673900019 ER PT J AU Marshall, WJ Brumage, EC Sliney, DH AF Marshall, Wesley J. Brumage, E. Christopher Sliney, David H. TI Intrabearn viewing of extended-source lasers with telescopes SO JOURNAL OF LASER APPLICATIONS LA English DT Article DE laser safety; ANSI Z136; IEC 60825-1; laser standard; maximum permissible exposure; angular subtense; laser source; extended source; optically aided viewing ID SYSTEMS; SAFETY AB Magnifying optics can increase the hazards for intrabeam viewing of lasers. Although it is rather straightforward to evaluate these increased hazards for point-source lasers at distance, limited information is available for determining the hazards from viewing extended-source lasers from within the beam when magnifying optics are used. Since intrabeam viewing of nearly all lasers results in an extremely small retinal image, commonly known as a "point source," extended-source maximum permissible exposures (MPEs) are seldom applicable; however, a substantial correction factor is allowed for extended-source lasers in the determination of the MPE. In those rare cases where an extended-source laser is viewed by an optical aid, it is important to avoid applying an incorrect and sometimes very large extended-source correction factor. Extended-source lasers were constructed and then measured to determine if standard hazard classification techniques, mainly developed for point-source lasers, would adequately assess the true optical viewing hazards from viewing extended-source lasers with telescopes. It was found that current techniques are adequate since telescopes would normally be expected to be used at tens or hundreds of meters from the laser source, although purposeful exposure at close distance would require specialized hazard evaluation techniques. (C) 2007 Laser Institute of America. C1 USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. RP Marshall, WJ (reprint author), USA, Ctr Hlth Promot & Prevent Med, Aberdeen Proving Ground, MD 21010 USA. EM wesley.marshall@us.army.mil NR 16 TC 1 Z9 1 U1 0 U2 0 PU LASER INST AMER PI ORLANDO PA 13501 INGENUITY DR, SUITE 128, ORLANDO, FL 32826 USA SN 1042-346X J9 J LASER APPL JI J. Laser Appl. PD MAY PY 2007 VL 19 IS 2 BP 89 EP 98 DI 10.2351/1.2567885 PG 10 WC Materials Science, Multidisciplinary; Optics; Physics, Applied SC Materials Science; Optics; Physics GA 165CU UT WOS:000246282300005 ER PT J AU Krus, TD Juliano, TF Kecskes, LJ VanLandingham, MR AF Krus, Tyler D. Juliano, Thomas F. Kecskes, Laszlo J. VanLandingham, Mark R. TI Initial plasticity onset in Zr- and Hf-rich bulk metallic glasses during instrumented indentation SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID SERRATED FLOW; SUPERCOOLED LIQUID; AMORPHOUS-ALLOYS; RATE DEPENDENCE; NANOINDENTATION; DEFORMATION AB Sudden jumps in nanoindentation load-displacement curves of bulk metallic glasses (BMGs) signify the onset of plastic deformation. These events are investigated on varying compositions of Zr- and Hf-rich BMGs. Load-versus-displacement graphs for spherical indentations are analyzed to determine displacement, load, intensity of deformation, energy per volume, energy loss, and pressure corresponding to these key locations. Attention is focused on pressure, energy loss, and energy per volume at initial plasticity in response to varying strain rates, indenter tip radii, preload, and material composition. Energy loss was found to correlate with preload. The Zr-rich metallic glass was found to plastically deform in response to smaller loads than Hf-rich specimens. C1 USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. RP VanLandingham, MR (reprint author), USA, Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA. EM mvanlandingham@arl.army.mil RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 20 TC 3 Z9 3 U1 0 U2 2 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD MAY PY 2007 VL 22 IS 5 BP 1265 EP 1269 DI 10.1557/JMR.2007.0185 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA 164TV UT WOS:000246258300021 ER PT J AU Seipel, B Erni, R Gupta, A Li, C Owens, FJ Rao, KV Browning, ND Moeck, P AF Seipel, B. Erni, R. Gupta, Amita Li, C. Owens, F. J. Rao, K. V. Browning, N. D. Moeck, P. TI Structural and ferromagnetic properties of Cu-doped GaN SO JOURNAL OF MATERIALS RESEARCH LA English DT Article ID ROOM-TEMPERATURE FERROMAGNETISM; ENERGY-LOSS SPECTROSCOPY; DILUTED MAGNETIC SEMICONDUCTORS; ZNO THIN-FILMS; SPINTRONICS; OXIDE; BULK; GAMNN; ALN AB The wurtzite polymorph of GaN was calcined with CuO in flowing nitrogen. As a result of this processing, both superconducting quantum interference device magnetometry and ferromagnetic resonance studies showed ferromagnetism in these samples at room temperature. These magnetic results are qualitatively consistent with very recent first-principle calculations [Wu et al., Appl. Phys. Lett. 89, 062505 (2006)] that predict ferromagnetism in Cu-doped GaN. We focus in this paper on analyzing changes in the GaN atomic and electronic structure due to calcination with CuO using multiple analytical methods. Quantitative powder x-ray diffraction (XRD) showed changes in the lattice constants of the GaN due to the incorporation of copper (and possibly oxygen). Energy-dispersive x-ray spectroscopy proved the incorporation of copper into the GaN crystal structure. Electron-gun monochromated electron energy loss spectroscopy showed CuO calcinations-induced GaN band gap changes and indicated changes in the atomic arrangements due to the calcination process. The fine structure of the N K-edge showed differences in the peak ratios with respect to higher nominal CuO contents, corresponding to an increase in the c-lattice constant as confirmed by XRD. C1 Portland State Univ, Dept Phys, Portland, OR 97207 USA. Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA. Royal Inst Technol, Dept Mat Sci, Tmfy MSE, SE-10044 Stockholm, Sweden. Lawrence Berkeley Natl Lab, Natl Ctr Electron Microscopy, Berkeley, CA 94720 USA. USA, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07896 USA. CUNY Hunter Coll, Dept Phys, New York, NY 10024 USA. RP Seipel, B (reprint author), Portland State Univ, Dept Phys, Portland, OR 97207 USA. EM bseipel@pdx.edu RI Rao, K.V./F-4577-2011; Erni, Rolf/P-7435-2014; OI Erni, Rolf/0000-0003-2391-5943; Browning, Nigel/0000-0003-0491-251X NR 45 TC 16 Z9 16 U1 1 U2 8 PU MATERIALS RESEARCH SOCIETY PI WARRENDALE PA 506 KEYSTONE DR, WARRENDALE, PA 15086 USA SN 0884-2914 J9 J MATER RES JI J. Mater. Res. PD MAY PY 2007 VL 22 IS 5 BP 1396 EP 1405 DI 10.1557/JMR.2007.0168 PG 10 WC Materials Science, Multidisciplinary SC Materials Science GA 164TV UT WOS:000246258300041 ER PT J AU Serichantalergs, O Bhuiyan, NA Nair, GB Chivaratanond, O Srijan, A Bodhidatta, L Anuras, S Mason, CJ AF Serichantalergs, Oralak Bhuiyan, Nurul Amin Nair, Gopinath Balakrish Chivaratanond, Orapan Srijan, Apichai Bodhidatta, Ladaporn Anuras, Sinn Mason, Carl J. TI The dominance of pandemic serovars of Vibrio parahaemolyticus in expatriates and sporadic cases of diarrhoea in Thailand, and a new emergent serovar (O3 : K46) with pandemic traits SO JOURNAL OF MEDICAL MICROBIOLOGY LA English DT Article ID THERMOSTABLE DIRECT HEMOLYSIN; CLINICAL SOURCES; SOUTHERN THAILAND; STRAINS; CLONE; GENE; SEQUENCE; SPREAD; PCR; HYBRIDIZATION AB Vibrio parahaemolyticus is a major cause of gastroenteritis worldwide. A total of 95 V. parahaemolyticus isolates belonging to 23 different serovars were identified in a case-control study of expatriates and Thai adults from 2001 to 2002 in Thailand. Fifty-two per cent of isolates (49/95) were resistant to ampicillin and sulfisoxazole, but all isolates were susceptible to ciprofloxacin and trimethoprim-sulfamethoxazole, two antibiotics commonly used to treat traveller's diarrhoea. All isolates were positive for the species-specific toxR gene, and 91 and 5 were positive for the thermostable direct haemolysin (tdh) gene and the tdh-related (trh) gene, respectively. Sixty-five isolates were assigned to the pandemic group of V. parahaemolyticus by a group-specific PCR and the presence of the orfB gene. The pandemic isolates belonged to three recognized serovars (O3 : K6, O1 : K25, O1 : KUT) and a new serovar, O3 : K46. This new serovar harboured pandemic traits. PFGE analysis revealed that all pandemic isolates including serovar O3 : K46 were closely related and clearly distinct from the non-pandemic isolates. In summary, three well-known serovars of pandemic V. parahaemolyticus isolates were identified as a major cause of diarrhoea in Thailand and a new V. parahaemolyticus isolate, serovar O3 : K46, with pandemic traits was detected. C1 Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. Int Ctr Diarrhoeal Dis Res ICDDRB, Dhaka 1212, Bangladesh. Bumrungrad Hosp, Bangkok 10110, Thailand. RP Serichantalergs, O (reprint author), Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand. EM oralaks@afrims.org RI Valle, Ruben/A-7512-2013; OI MASON, CARL/0000-0002-3676-2811 NR 31 TC 14 Z9 17 U1 0 U2 1 PU SOC GENERAL MICROBIOLOGY PI READING PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLAND SN 0022-2615 J9 J MED MICROBIOL JI J. Med. Microbiol. PD MAY PY 2007 VL 56 IS 5 BP 608 EP 613 DI 10.1099/jmm.0.47006-0 PG 6 WC Microbiology SC Microbiology GA 165RL UT WOS:000246323000007 PM 17446282 ER PT J AU Kositanont, U Chotinantakul, K Phulsuksombati, D Tribuddharat, C AF Kositanont, Uraiwan Chotinantakul, Kamonnaree Phulsuksombati, Duangporn Tribuddharat, Chanwit TI Assessment of Southern blot ribotyping for differentiation of Leptospira strains isolated from field rats SO JOURNAL OF MICROBIOLOGICAL METHODS LA English DT Article DE Leptospira; ribotyping; serovar identification; southern blot ribotyping ID FRAGMENT-LENGTH-POLYMORPHISMS; POLYMERASE-CHAIN-REACTION; ARBITRARILY PRIMED PCR; RIBOSOMAL-RNA GENES; INTERROGANS SEROVARS; SEROGROUP; IDENTIFICATION; HARDJO; ICTEROHAEMORRHAGIAE; BORGPETERSENII AB A Southern blot ribotyping based on EcoRV and HindIII digestion with two 16S and 23S rDNA probes for differentiating 27 Leptospira serovars was developed. The results between ribotyping and serotyping among 40 leptospiral strains isolated from field rats trapped in the northeastern region of Thailand during 1999-2000, were compared. A combination of Southern blot ribotyping, using EcoRV or HindIII digestion with both 16S and 23S rDNA as the probes, successfully typed 27 Leptospira serovars into 24 ribotypes with the discriminatory index (D) values of 0.99. The 16S- and 23S-EcoRV ribopatterns produced 17 and 9 profiles, respectively, with D values of 0.95 and 0.63, respectively. Ribopatterns of HindIII from both specific probes yielded 17 patterns. The D values of 16S- and 23S-HindIII ribopatterns were 0.94 and 0.93, respectively. With EcoRV digestion, the 166 rDNA probe was more discriminative than the 23S rDNA probe for differentiating Leptospira serovars. Moreover, the 16S-EcoRV (11 profiles), 16S-HindIII (11 profiles), and 23S-HindIII (10 profiles) riboparterns produced higher numbers of distinct and unique profiles than the 23S-EcoRV (5 profiles). The results showed 100% concordance between ribotyping and serotyping, leading to all 40 isolates being successfully typed. The current study revealed that ribotyping as a quick and powerful tool for differentiating Leptospira serovars, has potential value in epidemiological studies. (C) 2007 Elsevier B.V. All rights reserved. C1 Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. Armed Forces Res Inst Med Sci, Dept Vet Med, Bangkok 10400, Thailand. RP Kositanont, U (reprint author), Mahidol Univ, Fac Med, Siriraj Hosp, Dept Microbiol, Bangkok 10700, Thailand. EM gruks@mahidol.ac.th NR 33 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-7012 J9 J MICROBIOL METH JI J. Microbiol. Methods PD MAY PY 2007 VL 69 IS 2 BP 288 EP 297 DI 10.1016/j.mimet.2007.01.012 PG 10 WC Biochemical Research Methods; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA 165EX UT WOS:000246287900008 PM 17346835 ER EF